From 0a933f35785b2879c3cb014350abe04bb6a433b6 Mon Sep 17 00:00:00 2001 From: Dan Fornika Date: Wed, 31 Jul 2024 23:49:39 -0700 Subject: [PATCH 01/11] Add tbprofiler resistance prediction adjustment script (wip) --- ...CN-TB-2023.6-eng_catalogue_master_file.txt | 48153 ++++++++++++++++ ...djust_tbprofiler_resistance_predictions.py | 714 + 2 files changed, 48867 insertions(+) create mode 100644 assets/WHO-UCN-TB-2023.6-eng_catalogue_master_file.txt create mode 100755 bin/adjust_tbprofiler_resistance_predictions.py diff --git a/assets/WHO-UCN-TB-2023.6-eng_catalogue_master_file.txt b/assets/WHO-UCN-TB-2023.6-eng_catalogue_master_file.txt new file mode 100644 index 0000000..1e18d42 --- /dev/null +++ b/assets/WHO-UCN-TB-2023.6-eng_catalogue_master_file.txt @@ -0,0 +1,48153 @@ +drug gene mutation variant tier effect genomic position algorithm_pass_DATASET ALL Present_SOLO_SR_DATASET ALL Present_SOLO_R_DATASET ALL Present_SOLO_S_DATASET ALL Present_R_DATASET ALL Present_S_DATASET ALL Absent_R_DATASET ALL Absent_S_DATASET ALL Sens_DATASET ALL Sens_lb_DATASET ALL Sens_ub_DATASET ALL Spec_DATASET ALL Spec_lb_DATASET ALL Spec_ub_DATASET ALL PPV_DATASET ALL PPV_lb_DATASET ALL PPV_ub_DATASET ALL PPV_SOLO_DATASET ALL PPV_SOLO_lb_DATASET ALL PPV_SOLO_ub_DATASET ALL PPV_conditional_SOLO_DATASET ALL PPV_conditional_SOLO_lb_DATASET ALL PPV_conditional_SOLO_ub_DATASET ALL OR_SOLO_DATASET ALL OR_SOLO_exact_lb_DATASET ALL OR_SOLO_exact_ub_DATASET ALL OR_SOLO_pvalue_DATASET ALL OR_SOLO_pval_rank_DATASET ALL k_DATASET ALL OR_SOLO_FE_sig_DATASET ALL Neutral_masked_DATASET ALL OR_DATASET ALL OR_exact_lb_DATASET ALL OR_exact_ub_DATASET ALL Sens_SOLO_DATASET ALL Sens_SOLO_lb_DATASET ALL Sens_SOLO_ub_DATASET ALL Spec_SOLO_DATASET ALL Spec_SOLO_lb_DATASET ALL Spec_SOLO_ub_DATASET ALL Initial confidence grading ALL dataset_DATASET ALL INITIAL CONFIDENCE GRADING DATASET(S) Initial confidence grading WHO dataset_DATASET WHO algorithm_pass_DATASET WHO Present_SOLO_SR_DATASET WHO Present_SOLO_R_DATASET WHO Present_SOLO_S_DATASET WHO Present_R_DATASET WHO Present_S_DATASET WHO Absent_R_DATASET WHO Absent_S_DATASET WHO Sens_DATASET WHO Sens_lb_DATASET WHO Sens_ub_DATASET WHO Spec_DATASET WHO Spec_lb_DATASET WHO Spec_ub_DATASET WHO PPV_DATASET WHO PPV_lb_DATASET WHO PPV_ub_DATASET WHO PPV_SOLO_DATASET WHO PPV_SOLO_lb_DATASET WHO PPV_SOLO_ub_DATASET WHO PPV_conditional_SOLO_DATASET WHO PPV_conditional_SOLO_lb_DATASET WHO PPV_conditional_SOLO_ub_DATASET WHO OR_SOLO_DATASET WHO OR_SOLO_exact_lb_DATASET WHO OR_SOLO_exact_ub_DATASET WHO OR_SOLO_pvalue_DATASET WHO OR_SOLO_pval_rank_DATASET WHO k_DATASET WHO OR_SOLO_FE_sig_DATASET WHO Neutral_masked_DATASET WHO setA_DATASET WHO setB_DATASET WHO setC_DATASET WHO setD1_DATASET WHO setD2_DATASET WHO v1_DATASET WHO literature_DATASET WHO OR_DATASET WHO OR_exact_lb_DATASET WHO OR_exact_ub_DATASET WHO Sens_SOLO_DATASET WHO Sens_SOLO_lb_DATASET WHO Sens_SOLO_ub_DATASET WHO Spec_SOLO_DATASET WHO Spec_SOLO_lb_DATASET WHO Spec_SOLO_ub_DATASET WHO Present_NoPheno_no pDST (WHO guidance before cat ver1) Miotto et al. (PMID 29284687), WHO NGS Guide 2018_Source of additional grading evidence (WHO guidance before cat ver1) RIF CC guide 2021_Source of additional grading evidence (Previous WHO guidance) WHO Catalogue ver1_Source of additional grading evidence Selection evidence_Source of additional grading evidence (WHO guidance before cat ver1) WHO_endorsed_assay_Source of additional grading evidence Additional grading criteria applied FINAL CONFIDENCE GRADING Comment CHANGES vs ver1 Relaxed thresholds simulation (BDQ_Rv0678, CFZ_Rv0678, INH_katG, DLM_ddn/fbiA/fbiB/fbiC/fgd1/Rv2983) Silent mutation Listed in abridged tables Additional grading Footnote CHANGES vs ver1 +Amikacin bacA c.102G>A bacA_c.102G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.1044G>A bacA_c.1044G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 91 1112 2369 20866 0.0369918699186991 0.029886053300265 0.045225275835744 0.949403949403949 0.946423613683619 0.952264699984932 0.0756442227763923 0.0613381788396535 0.092063747325373 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.720793310476144 0.573145950871411 0.897251723009581 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 65 741 1046 7032 0.0585058505850585 0.0454402893186132 0.0739661305881655 0.904670011578541 0.897924577181072 0.911110222561673 0.0806451612903225 0.0627891721268219 0.101636476085609 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 0 0.589715205796518 0.446709237182612 0.767639636046602 NA NA NA NA NA NA 1049 5) Not assoc w R Now listed Silent mutation no 0 +Amikacin bacA c.105C>G bacA_c.105C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.1065T>G bacA_c.1065T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 21.6259333410942 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 37.2625869115887 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.1080G>A bacA_c.1080G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.1140G>A bacA_c.1140G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.1170G>A bacA_c.1170G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.1194C>T bacA_c.1194C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.1210C>T bacA_c.1210C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.1212G>A bacA_c.1212G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.1212G>C bacA_c.1212G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.1242G>A bacA_c.1242G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 24 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.129T>C bacA_c.129T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.1317C>T bacA_c.1317C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.22908065008664 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 1110 7773 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 1 0.999525536566873 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.179394825906045 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.1323G>C bacA_c.1323G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.1348C>T bacA_c.1348C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.135G>A bacA_c.135G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.1371G>A bacA_c.1371G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 2459 21976 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999908999909 0.999671315452743 0.999988979276808 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 4.46848312322082 0.0757100934104112 86.0774363890598 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 1110 7772 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.99987134954329 0.999283416286792 0.999996742857744 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 7.0018018018018 0.0891187877143753 547.10724479397 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.1374C>T bacA_c.1374C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.138C>G bacA_c.138C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.1405C>T bacA_c.1405C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.1426C>T bacA_c.1426C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.1428G>A bacA_c.1428G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.1527C>T bacA_c.1527C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.1533G>A bacA_c.1533G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.1542C>T bacA_c.1542C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 5 135 2455 21843 0.00203252032520325 0.000660272864287742 0.00473679855039338 0.993857493857494 0.992733705296059 0.994847465956359 0.0357142857142857 0.0116962400384683 0.0813757046906199 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.329531568228105 0.105211549958286 0.789329180380385 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 16 1111 7757 0 0 0.00331481736263177 0.997941592692654 0.996659422164099 0.998822998929686 0 0 0.205907214207822 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.81358991296359 NA NA NA NA NA NA 407 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.1563C>A bacA_c.1563C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 37.2625869115887 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.1572C>T bacA_c.1572C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.1608A>T bacA_c.1608A>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 10 2460 21968 0 0 0.00149842073847528 0.999544999544999 0.999163397681526 0.999781788721324 0 0 0.30849710781876 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.98680916993403 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 64 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.1617C>T bacA_c.1617C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.1621C>T bacA_c.1621C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 13.5427650126618 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.1623G>A bacA_c.1623G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 254 2456 21724 0.0016260162601626 0.000443206823318481 0.00415796841630328 0.988442988442988 0.98694073346712 0.989813881703954 0.0155038759689922 0.00424002258879533 0.0392181109900084 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.139295698786837 0.0376324798462433 0.361552870393116 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 9 1111 7764 0 0 0.00331481736263177 0.998842145889618 0.997803175208698 0.999470423012169 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.54586915871032 NA NA NA NA NA NA 644 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.1632A>G bacA_c.1632A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.1659C>A bacA_c.1659C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 21.6259333410942 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.1665G>A bacA_c.1665G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.1779G>A bacA_c.1779G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.1782C>T bacA_c.1782C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 3 2459 21975 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.9998634998635 0.999601141012814 0.999971849505602 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.97885319235461 0.0567200675769732 37.1234870649317 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.1794G>A bacA_c.1794G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.1821T>C bacA_c.1821T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 21.6259333410942 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 16.9345443329059 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.1842G>A bacA_c.1842G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.1848A>G bacA_c.1848A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 2458 21978 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 1 0.99983216990204 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.67834993427241 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.1857C>T bacA_c.1857C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.1869T>C bacA_c.1869T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 21.6259333410942 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.189C>T bacA_c.189C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.-18T>C bacA_c.-18T>C 2 upstream_gene_variant 2064746 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin bacA c.1917G>A bacA_c.1917G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.1917G>C bacA_c.1917G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.1919A>G bacA_c.1919A>G 2 stop_retained_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.201G>A bacA_c.201G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.-21G>A bacA_c.-21G>A 2 upstream_gene_variant 2064749 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin bacA c.234A>C bacA_c.234A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.243A>G bacA_c.243A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 13.5427650126618 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA 12 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.250C>T bacA_c.250C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.267C>T bacA_c.267C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.270C>T bacA_c.270C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.282C>T bacA_c.282C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 2460 21973 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.75275991328737 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.288C>T bacA_c.288C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.291G>A bacA_c.291G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.309C>T bacA_c.309C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 10 2460 21968 0 0 0.00149842073847528 0.999544999544999 0.999163397681526 0.999781788721324 0 0 0.30849710781876 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.98680916993403 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 16.9345443329059 NA NA NA NA NA NA 47 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.312G>A bacA_c.312G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.-32G>A bacA_c.-32G>A 2 upstream_gene_variant 2064760 NA 0 0 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1773 1832 False False Inf 0.22908065008664 Inf 0 0 0.00149902964335061 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA c.-32G>T bacA_c.-32G>T 2 upstream_gene_variant 2064760 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA c.-33C>T bacA_c.-33C>T 2 upstream_gene_variant 2064761 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA c.-34C>A bacA_c.-34C>A 2 upstream_gene_variant 2064762 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA c.351C>T bacA_c.351C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 37.2625869115887 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.357A>G bacA_c.357A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 21.6259333410942 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.387C>T bacA_c.387C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.-40C>T bacA_c.-40C>T 2 upstream_gene_variant 2064768 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance New Uncertain no 0 +Amikacin bacA c.414G>A bacA_c.414G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.438G>A bacA_c.438G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.501C>T bacA_c.501C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.507G>A bacA_c.507G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 20 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.510C>T bacA_c.510C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.516C>T bacA_c.516C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 13.5427650126618 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 37.2625869115887 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.-52A>C bacA_c.-52A>C 2 upstream_gene_variant 2064780 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA c.549C>T bacA_c.549C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.22908065008664 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 1110 7773 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 1 0.999525536566873 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.179394825906045 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.588C>A bacA_c.588C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.-58T>C bacA_c.-58T>C 2 upstream_gene_variant 2064786 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin bacA c.591C>T bacA_c.591C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.624C>T bacA_c.624C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.633C>G bacA_c.633C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.633C>T bacA_c.633C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.-63G>T bacA_c.-63G>T 2 upstream_gene_variant 2064791 1 1 1 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.22908065008664 Inf 0.100662902037809 42.5 1832 False False Inf 0.22908065008664 Inf 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA c.63T>C bacA_c.63T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 16 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.651G>A bacA_c.651G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 13 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.651G>C bacA_c.651G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.678T>A bacA_c.678T>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.678T>C bacA_c.678T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.-67G>C bacA_c.-67G>C 2 upstream_gene_variant 2064795 1 3 0 3 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 21.6259333410942 1 662.5 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 37.2625869115887 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 2 3) Uncertain significance New Uncertain no 0 +Amikacin bacA c.681T>G bacA_c.681T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 13.5427650126618 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 37.2625869115887 NA NA NA NA NA NA 12 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.705C>T bacA_c.705C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.714C>G bacA_c.714C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.759C>A bacA_c.759C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.762G>T bacA_c.762G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.-76G>A bacA_c.-76G>A 2 upstream_gene_variant 2064804 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1764 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 958 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA c.783C>T bacA_c.783C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA c.-81_-76dupTCGGTG bacA_c.-81_-76dupTCGGTG 2 upstream_gene_variant 2064803 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA c.84G>C bacA_c.84G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin bacA deletion bacA_deletion 2 feature_ablation (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1759 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Amikacin bacA LoF bacA_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 32 2 30 6 47 2454 21931 0.0024390243902439 0.000895588528695574 0.00530111511191433 0.997861497861498 0.9971572485627 0.998428298886553 0.113207547169811 0.0426963949362736 0.230289916370863 0.0625 0.00766073634645639 0.208069429895007 0.0408163265306122 0.0049818418349713 0.139787187022463 0.595789187720728 0.0689497394238682 2.35052116585926 0.766553615154566 142 1832 False False 1.14087291265671 0.39817619025032 2.67759043962829 0.000814332247557003 9.86346319130786e-05 0.00293852082826415 0.997861497861498 0.9971572485627 0.998428298886553 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 1 9 4 17 1107 7756 0.0036003600360036 0.000981821480890848 0.0091924849732633 0.997812942235945 0.99650061054502 0.998725458183247 0.19047619047619 0.0544635681784068 0.419066041183528 0.1 0.00252857854446178 0.445016117028195 0.0555555555555555 0.00140555616736942 0.272943599673368 0.778480377396366 0.0177450768573389 5.6265331944181 1 267 981 False False 0 0 0 0 0 0 0 1.64854668154524 0.402808222834578 5.06618985573416 0.000902527075812274 2.28497461466115e-05 0.00501819727739755 0.997812942235945 0.99650061054502 0.998725458183247 NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Ala152Val bacA_p.Ala152Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Ala170Thr bacA_p.Ala170Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Ala197Val bacA_p.Ala197Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 3 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Ala211Pro bacA_p.Ala211Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Ala249Thr bacA_p.Ala249Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Ala285Thr bacA_p.Ala285Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 37.2625869115887 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Ala289Val bacA_p.Ala289Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Ala299Thr bacA_p.Ala299Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 21.6249500611508 1 662.5 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 16.9345443329059 1 267 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 2 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Ala359Val bacA_p.Ala359Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Ala36Gly bacA_p.Ala36Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Ala396Val bacA_p.Ala396Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Ala413Thr bacA_p.Ala413Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Ala438Val bacA_p.Ala438Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Ala464Thr bacA_p.Ala464Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Ala464Val bacA_p.Ala464Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Ala474Gly bacA_p.Ala474Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 3 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Ala523Thr bacA_p.Ala523Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1754 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Ala535Thr bacA_p.Ala535Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Ala588Thr bacA_p.Ala588Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1768 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Ala630Val bacA_p.Ala630Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 6 2460 21972 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 9.75231611160222 1 662.5 1832 False False 0 0 7.5904311186467 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 15 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Ala634Thr bacA_p.Ala634Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Ala635Pro bacA_p.Ala635Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1783 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 965 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 2 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Arg115Ser bacA_p.Arg115Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Arg119Gln bacA_p.Arg119Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1761 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Arg169Lys bacA_p.Arg169Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Arg278Cys bacA_p.Arg278Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Arg326His bacA_p.Arg326His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1757 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Arg329Leu bacA_p.Arg329Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1769 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Arg356Gln bacA_p.Arg356Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1779 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Arg441Leu bacA_p.Arg441Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Arg452Leu bacA_p.Arg452Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Arg486Gln bacA_p.Arg486Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1749 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Arg508Cys bacA_p.Arg508Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 346.534733964433 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Arg508Pro bacA_p.Arg508Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1776 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Arg545Ser bacA_p.Arg545Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 21.6259333410942 1 662.5 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Arg594His bacA_p.Arg594His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Asn183His bacA_p.Asn183His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Asn279Thr bacA_p.Asn279Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Asn335Ser bacA_p.Asn335Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1778 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 963 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 6 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Asn515Thr bacA_p.Asn515Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1760 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Asn85Ser bacA_p.Asn85Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Asp110Ala bacA_p.Asp110Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1774 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Asp178Glu bacA_p.Asp178Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 346.534733964433 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 959 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Asp18Asn bacA_p.Asp18Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Asp379fs bacA_p.Asp379fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Asp379His bacA_p.Asp379His 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 13.5427650126618 1 662.5 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Asp406Ala bacA_p.Asp406Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1770 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Asp423Gly bacA_p.Asp423Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1786 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Asp451Asn bacA_p.Asp451Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Asp451Glu bacA_p.Asp451Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1789 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Asp509Asn bacA_p.Asp509Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1780 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 964 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Asp546Ala bacA_p.Asp546Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 13 0 13 0 14 2460 21964 0 0 0.00149842073847528 0.999362999362999 0.998931451908832 0.999651703457902 0 0 0.231635761650116 0 0 0.24705263800047 0 0 0.231635761650116 0 0 2.9315680573594 0.633597202329469 136.5 1832 False False 0 0 2.69356616691972 0 0 0.00149842073847528 0.999362999362999 0.998931451908832 0.999651703457902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 37.2625869115887 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 26 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Asp599Ala bacA_p.Asp599Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1755 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Cys33Tyr bacA_p.Cys33Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1775 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Cys538Arg bacA_p.Cys538Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Cys538Gly bacA_p.Cys538Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Gln100His bacA_p.Gln100His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1752 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Gln361Lys bacA_p.Gln361Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Gln618Leu bacA_p.Gln618Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Glu298Asp bacA_p.Glu298Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Glu309Asp bacA_p.Glu309Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1765 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Glu433Lys bacA_p.Glu433Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Glu490Lys bacA_p.Glu490Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Gly105Asp bacA_p.Gly105Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1784 1832 False False Inf 0.22908065008664 Inf 0 0 0.00149902964335061 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Gly168Arg bacA_p.Gly168Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Gly168Ser bacA_p.Gly168Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1750 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Gly310Ser bacA_p.Gly310Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Gly360Arg bacA_p.Gly360Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Gly403Glu bacA_p.Gly403Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Gly554fs bacA_p.Gly554fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 10 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Gly584Glu bacA_p.Gly584Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1781 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Gly624Asp bacA_p.Gly624Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1782 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Gly625Ser bacA_p.Gly625Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Gly72Ala bacA_p.Gly72Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.His615Tyr bacA_p.His615Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1753 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Ile264Thr bacA_p.Ile264Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Ile273Met bacA_p.Ile273Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.22908065008664 Inf 0.100662902037809 42.5 1832 False False Inf 0.22908065008664 Inf 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Ile273Thr bacA_p.Ile273Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 94 1119 2366 20859 0.0382113821138211 0.0309869451348197 0.0465598523268995 0.949085449085449 0.94609654138001 0.9519548600255 0.0774938169826875 0.0630739769737972 0.0939995165540935 NA NA NA 0 0 0.00329115797708621 NA NA NA NA 1756 1832 False True 0.740587727389129 0.590972478412021 0.918985755643469 0 0 0.00155790585122214 0.949085449085449 0.94609654138001 0.9519548600255 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 68 751 1043 7022 0.0612061206120612 0.0478388722591005 0.0769514646414224 0.90338350701145 0.896599358725109 0.909863425424289 0.083028083028083 0.0650491812669483 0.104072505674098 NA NA NA 0 0 0.00489991273196209 NA NA NA NA 954 981 False True 0 1 1 0 0 0 0 0.60960074965562 0.464462494292012 0.789493838165658 0 0 0.00353055007551288 0.90338350701145 0.896599358725109 0.909863425424289 1056 5) Not assoc w R New NotAwR yes 5 +Amikacin bacA p.Ile321Thr bacA_p.Ile321Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Ile443Val bacA_p.Ile443Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Ile520fs bacA_p.Ile520fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Ile520Phe bacA_p.Ile520Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1766 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 960 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Ile54fs bacA_p.Ile54fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Ile603Val bacA_p.Ile603Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 36 1316 2424 20662 0.0146341463414634 0.0102700682157941 0.0202027469011212 0.94012194012194 0.936903784783525 0.943223071531771 0.0266272189349112 0.0187175089403325 0.0366740655403668 NA NA NA 0 0 0.00279917487291076 NA NA NA NA 1767 1832 False True 0.233177345090132 0.162166416302655 0.325534230307754 0 0 0.00152065758311405 0.94012194012194 0.936903784783525 0.943223071531771 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 8 219 1103 7554 0.0072007200720072 0.00311373583188468 0.0141387520551147 0.971825549980702 0.967901096584534 0.975390626651318 0.0352422907488986 0.0153357035583918 0.0682578424251111 NA NA NA 0 0 0.0167031280931588 NA NA NA NA 961 981 False True 1 1 1 0 0 0 0 0.250176976862603 0.106384078747037 0.503689720716491 0 0 0.00333881937479895 0.971825549980702 0.967901096584534 0.975390626651318 3622 5) Not assoc w R New NotAwR yes 5 +Amikacin bacA p.Leu157Pro bacA_p.Leu157Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Leu175Val bacA_p.Leu175Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 3 1 2457 21977 0.00121951219512195 0.00025156337591866 0.00355975660270706 0.9999544999545 0.999746516336938 0.999998848039248 0.75 0.194120449683243 0.99369053679029 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 8.94464794464794 0.11390310042426 697.882459365427 0.191064085322895 66 1832 False False 26.8339438339438 2.15301335174262 1395.79975994304 0.000406834825061025 1.03001129356897e-05 0.00226463172978561 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Leu313Ile bacA_p.Leu313Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Leu446Arg bacA_p.Leu446Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Leu44Ser bacA_p.Leu44Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Leu529Pro bacA_p.Leu529Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Leu551fs bacA_p.Leu551fs 2 frameshift (see "Genomic_coordinates" sheet) 1 16 0 16 4 22 2456 21956 0.0016260162601626 0.000443206823318481 0.00415796841630328 0.998998998998999 0.998484862369405 0.999372575026909 0.153846153846153 0.0435634765389238 0.348678785535361 0 0 0.205907214207822 0 0 0.154372512815574 0 0 2.31978938259773 0.39644760560681 96 1832 False False 1.62540716612377 0.406851741272302 4.7915450962514 0 0 0.00150085933084757 0.998998998998999 0.998484862369405 0.999372575026909 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 3 6 1108 7767 0.0027002700270027 0.000557207149395569 0.00787087587058421 0.999228097259745 0.998320655545558 0.999716674296114 0.333333333333333 0.0748546314196918 0.700704943791459 0 0 0.602364635616474 0 0 0.4592581264399 0 0 10.630482563151 1 267 981 False False 0 0 0 0 0 0 0 3.50496389891696 0.566273672604293 16.4275988267163 0 0 0.00332377756768462 0.999228097259745 0.998320655545558 0.999716674296114 11 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Leu585Pro bacA_p.Leu585Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Leu75fs bacA_p.Leu75fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Lys4Asn bacA_p.Lys4Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 5 2460 21973 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 21.6239667816724 1 662.5 1832 False False 0 0 9.75275991328737 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 955 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Lys549Thr bacA_p.Lys549Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 9 2460 21969 0 0 0.00149842073847528 0.999590499590499 0.999222783640785 0.999812733785825 0 0 0.336267116879942 0 0 0.521823750104981 0 0 0.336267116879942 0 0 9.75098470649694 1 662.5 1832 False False 0 0 4.52743474605681 0 0 0.00149842073847528 0.999590499590499 0.999222783640785 0.999812733785825 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 6 1111 7767 0 0 0.00331481736263177 0.999228097259745 0.998320655545558 0.999716674296114 0 0 0.4592581264399 0 0 0.602364635616474 0 0 0.4592581264399 0 0 10.6017544481422 1 267 981 False False 0 0 0 0 0 0 0 0 0 5.94541565066903 0 0 0.00331481736263177 0.999228097259745 0.998320655545558 0.999716674296114 NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Met131Thr bacA_p.Met131Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1762 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Met131Val bacA_p.Met131Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1785 1832 False False Inf 0.22908065008664 Inf 0 0 0.00149902964335061 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Met250Val bacA_p.Met250Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Met494Leu bacA_p.Met494Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 21.6259333410942 1 662.5 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Met95Ile bacA_p.Met95Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 5 2460 21973 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1771 1832 False False 0 0 9.75275991328737 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1111 7769 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 962 981 False False 0 0 0 0 0 0 0 0 0 10.6044836876068 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 5 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Phe302fs bacA_p.Phe302fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1788 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Phe384Val bacA_p.Phe384Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Pro17Leu bacA_p.Pro17Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1748 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Pro347Leu bacA_p.Pro347Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 13 0 13 6 14 2454 21964 0.0024390243902439 0.000895588528695574 0.00530111511191433 0.999362999362999 0.998931451908832 0.999651703457902 0.3 0.118931590405727 0.542789182276289 0 0 0.24705263800047 0 0 0.231635761650116 0 0 2.93873666822311 0.633321910829083 134 1832 False False 3.83583653510303 1.20691390032356 10.638850824123 0 0 0.00150208160595732 0.999362999362999 0.998931451908832 0.999651703457902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 16.9345443329059 1 267 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 2 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Pro3Thr bacA_p.Pro3Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Pro536Arg bacA_p.Pro536Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Pro609His bacA_p.Pro609His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Pro609Ser bacA_p.Pro609Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Pro8Leu bacA_p.Pro8Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Ser116Leu bacA_p.Ser116Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Ser207Ala bacA_p.Ser207Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Ser245Phe bacA_p.Ser245Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Ser481Ala bacA_p.Ser481Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1777 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Ser552fs bacA_p.Ser552fs 2 frameshift (see "Genomic_coordinates" sheet) 1 10 1 9 1 16 2459 21962 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999271999271999 0.998818040931792 0.999583829243268 0.0588235294117647 0.00148817439126663 0.28688939666722 0.1 0.00252857854446178 0.445016117028195 0.0588235294117647 0.00148817439126663 0.28688939666722 0.992363652794722 0.0226315498715242 7.16722106077724 1 662.5 1832 False False 0.558204554697031 0.013308736221939 3.59638627394134 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999271999271999 0.998818040931792 0.999583829243268 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 6 1111 7767 0 0 0.00331481736263177 0.999228097259745 0.998320655545558 0.999716674296114 0 0 0.4592581264399 0 0 0.841886116991581 0 0 0.4592581264399 0 0 37.2434212359824 1 75.5 981 False False 0 0 0 0 0 0 0 0 0 5.94541565066903 0 0 0.00331481736263177 0.999228097259745 0.998320655545558 0.999716674296114 1 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Ser604Cys bacA_p.Ser604Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Thr112Ala bacA_p.Thr112Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 0 8 2460 21970 0 0 0.00149842073847528 0.999635999635999 0.999282900840091 0.999842837798826 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 5.2353912865109 1 165 1832 False False 0 0 5.2353912865109 0 0 0.00149842073847528 0.999635999635999 0.999282900840091 0.999842837798826 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 16.9345443329059 1 267 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 2 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Thr210Lys bacA_p.Thr210Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 346.534733964433 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Thr419Ala bacA_p.Thr419Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1763 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 957 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Thr419Ile bacA_p.Thr419Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1772 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Thr436Met bacA_p.Thr436Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Thr45Ala bacA_p.Thr45Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 9 1 2451 21977 0.00365853658536585 0.00167423871507945 0.00693363251119005 0.9999544999545 0.999746516336938 0.999998848039248 0.9 0.554983882971804 0.997471421455538 NA NA NA 0 0 0.975 NA NA NA NA 1751 1832 False False 80.6988984088127 11.1703023053441 3462.53244434909 0 0 0.00150391875593933 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 6 1 1105 7772 0.0054005400540054 0.00198440436427563 0.0117173898239407 0.99987134954329 0.999283416286792 0.999996742857744 0.857142857142857 0.421276802956804 0.996389703138099 NA NA NA 0 0 0.975 NA NA NA NA 953 981 False False 0 0 0 0 0 0 0 42.2009049773755 5.10820263869625 1919.4885210228 0 0 0.00333278634422504 0.99987134954329 0.999283416286792 0.999996742857744 4 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Thr467Ser bacA_p.Thr467Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Thr483Ile bacA_p.Thr483Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 21.6259333410942 1 662.5 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Trp122Ser bacA_p.Trp122Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Trp122* bacA_p.Trp122* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1758 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 956 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Trp153Ser bacA_p.Trp153Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 81 0 81 3 88 2457 21890 0.00121951219512195 0.00025156337591866 0.00355975660270706 0.995995995995996 0.99506924809324 0.996787470454259 0.0329670329670329 0.00685088631087866 0.0933324280056435 0 0 0.0445202624563217 0 0 0.041052629058078 0 0 0.415457831648599 0.000300106383619999 8 1832 False False 0.303724053724053 0.0614192213150093 0.91828340630709 0 0 0.00150024893893223 0.995995995995996 0.99506924809324 0.996787470454259 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 18 0 18 0 19 1111 7754 0 0 0.00331481736263177 0.997555641322526 0.996185451564254 0.998527714753364 0 0 0.176466911806965 0 0 0.185301968137852 0 0 0.176466911806965 0 0 1.59021224670024 0.154626669332542 31 981 False False 0 0 0 0 0 0 0 0 0 1.49813089681429 0 0 0.00331481736263177 0.997555641322526 0.996185451564254 0.998527714753364 30 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Trp153* bacA_p.Trp153* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1787 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 966 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Trp156Cys bacA_p.Trp156Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Trp627Arg bacA_p.Trp627Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 1 6 1 6 2459 21972 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999726999726999 0.999405888764937 0.999899807333004 0.142857142857142 0.00361029686190058 0.578723197043195 0.142857142857142 0.00361029686190058 0.578723197043195 0.142857142857142 0.00361029686190058 0.578723197043195 1.48922326148841 0.0323630859858146 12.2827873722144 0.524209484734124 109 1832 False False 1.48922326148841 0.0323630859858146 12.2827873722144 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999726999726999 0.999405888764937 0.999899807333004 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Tyr144Asp bacA_p.Tyr144Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Tyr171Asp bacA_p.Tyr171Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Tyr172Cys bacA_p.Tyr172Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Tyr43Ser bacA_p.Tyr43Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.22908065008664 Inf 0.100662902037809 42.5 1832 False False Inf 0.22908065008664 Inf 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Tyr513Cys bacA_p.Tyr513Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Tyr90Cys bacA_p.Tyr90Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Val136Met bacA_p.Val136Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Val139Ile bacA_p.Val139Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Val219Ala bacA_p.Val219Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 3 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Val291Phe bacA_p.Val291Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Val308Ala bacA_p.Val308Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Val351fs bacA_p.Val351fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.22908065008664 Inf 0.100662902037809 42.5 1832 False False Inf 0.22908065008664 Inf 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1110 7773 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 1 0.999525536566873 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.179394825906045 Inf 0.125056280954525 25.5 981 False False 0 0 0 0 0 0 0 Inf 0.179394825906045 Inf 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 1 0.999525536566873 1 NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Val351Ile bacA_p.Val351Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Val502Leu bacA_p.Val502Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin bacA p.Val510Ala bacA_p.Val510Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 346.503368577436 1 662.5 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 4 1111 7769 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 271.601013915947 1 75.5 981 False False 0 0 0 0 0 0 0 0 0 10.6044836876068 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 NA 3) Uncertain significance New Uncertain no 0 +Amikacin ccsA c.-106G>C ccsA_c.-106G>C 2 upstream_gene_variant 619785 1 8 0 8 4 17 2456 21961 0.0016260162601626 0.000443206823318481 0.00415796841630328 0.999226499226499 0.99876183824676 0.999549344777619 0.19047619047619 0.0544635681784068 0.419066041183528 0 0 0.369416647552819 0 0 0.195064322969093 0 0 5.24177533269402 1 662.5 1832 False False 2.1039471163058 0.51461808033832 6.45600750703637 0 0 0.00150085933084757 0.999226499226499 0.99876183824676 0.999549344777619 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 4 17 1107 7756 0.0036003600360036 0.000981821480890848 0.0091924849732633 0.997812942235945 0.99650061054502 0.998725458183247 0.19047619047619 0.0544635681784068 0.419066041183528 0 0 0.369416647552819 0 0 0.195064322969093 0 0 4.1106711716398 0.60712731965117 50 981 False False 0 0 0 0 0 0 0 1.64854668154524 0.402808222834578 5.06618985573416 0 0 0.0033267750768979 0.997812942235945 0.99650061054502 0.998725458183247 2 3) Uncertain significance No change no 1 +Amikacin ccsA c.-107G>A ccsA_c.-107G>A 2 upstream_gene_variant 619784 NA 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1731 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin ccsA c.-10G>A ccsA_c.-10G>A 2 upstream_gene_variant 619881 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin ccsA c.126C>T ccsA_c.126C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 8 0 2452 21978 0.0032520325203252 0.00140501011649083 0.00639769284617963 1 0.99983216990204 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 15.2849691252239 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 1108 7773 0.0027002700270027 0.000557207149395569 0.00787087587058421 1 0.999525536566873 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 2.89424461850611 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.-134G>T ccsA_c.-134G>T 2 upstream_gene_variant 619757 NA 0 0 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1743 1832 False False Inf 0.22908065008664 Inf 0 0 0.00149902964335061 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin ccsA c.139C>T ccsA_c.139C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 8 300 2452 21678 0.0032520325203252 0.00140501011649083 0.00639769284617963 0.986349986349986 0.984727197023659 0.987842188727027 0.0259740259740259 0.0112789886317326 0.0505357636648146 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.235758564437194 0.100730626522542 0.471376323784368 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 30 1108 7743 0.0027002700270027 0.000557207149395569 0.00787087587058421 0.996140486298726 0.994494851870603 0.997394533107523 0.0909090909090909 0.0191549429874049 0.243316350759155 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.698826714801444 0.136258611882488 2.2529632353935 NA NA NA NA NA NA 281 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.-141C>T ccsA_c.-141C>T 2 upstream_gene_variant 619750 1 0 0 0 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1738 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin ccsA c.-143G>A ccsA_c.-143G>A 2 upstream_gene_variant 619748 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin ccsA c.-144C>A ccsA_c.-144C>A 2 upstream_gene_variant 619747 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1721 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin ccsA c.144C>T ccsA_c.144C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.-149G>A ccsA_c.-149G>A 2 upstream_gene_variant 619742 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin ccsA c.150G>A ccsA_c.150G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.-162G>A ccsA_c.-162G>A 2 upstream_gene_variant 619729 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1736 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin ccsA c.-16C>T ccsA_c.-16C>T 2 upstream_gene_variant 619875 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1732 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin ccsA c.189C>T ccsA_c.189C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.18C>G ccsA_c.18C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.18C>T ccsA_c.18C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 21.6259333410942 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.-191C>T ccsA_c.-191C>T 2 upstream_gene_variant 619700 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Amikacin ccsA c.195G>A ccsA_c.195G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.-22C>A ccsA_c.-22C>A 2 upstream_gene_variant 619869 1 5 0 5 0 5 2460 21973 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 9.75275991328737 1 662.5 1832 False False 0 0 9.75275991328737 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Amikacin ccsA c.234G>A ccsA_c.234G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.234G>C ccsA_c.234G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.240G>T ccsA_c.240G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.27C>T ccsA_c.27C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.282C>T ccsA_c.282C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.288G>C ccsA_c.288G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.-30_-29insGCG ccsA_c.-30_-29insGCG 2 upstream_gene_variant 619861 1 1 0 1 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 346.534733964433 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin ccsA c.333C>T ccsA_c.333C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.339C>T ccsA_c.339C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.351C>T ccsA_c.351C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 2460 21972 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.5904311186467 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 16.9345443329059 NA NA NA NA NA NA 13 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.372C>T ccsA_c.372C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.381C>T ccsA_c.381C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.390C>T ccsA_c.390C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 6 2459 21972 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999726999726999 0.999405888764937 0.999899807333004 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.48922326148841 0.0323630859858146 12.2827873722144 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.393T>G ccsA_c.393T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.424C>T ccsA_c.424C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.426G>C ccsA_c.426G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.22908065008664 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.435G>A ccsA_c.435G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.468C>T ccsA_c.468C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 12 2458 21966 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.999453999453999 0.999046441372309 0.999717842739244 0.142857142857142 0.0177945154831915 0.428129160909698 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.48942229454841 0.161783141245437 6.69550050587623 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 11 1109 7762 0.0018001800180018 0.000218084550259369 0.00648759665094944 0.998584844976199 0.99746931080593 0.99929335470516 0.153846153846153 0.0192066719825284 0.454471055676557 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.27256332486269 0.13690598898368 5.84201040583434 NA NA NA NA NA NA 19 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.474C>T ccsA_c.474C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.507C>T ccsA_c.507C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.22908065008664 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.519C>T ccsA_c.519C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.525T>C ccsA_c.525T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 37.2625869115887 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.528G>A ccsA_c.528G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 2460 21972 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.5904311186467 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 16.9345443329059 NA NA NA NA NA NA 14 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.543C>G ccsA_c.543C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.561G>A ccsA_c.561G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.567C>T ccsA_c.567C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.573C>T ccsA_c.573C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.576C>T ccsA_c.576C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.582C>T ccsA_c.582C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 21.6259333410942 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.585G>A ccsA_c.585G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.600A>C ccsA_c.600A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 37.2625869115887 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.607C>T ccsA_c.607C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.621C>T ccsA_c.621C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.630C>T ccsA_c.630C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.633G>T ccsA_c.633G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.634C>T ccsA_c.634C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.636G>T ccsA_c.636G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 21.6259333410942 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.63C>T ccsA_c.63C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.648G>A ccsA_c.648G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.663T>C ccsA_c.663T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 21 226 2439 21752 0.00853658536585366 0.00529182386941496 0.0130196206993337 0.989716989716989 0.98829372084335 0.991008393680232 0.0850202429149797 0.0533993803599651 0.127026124214071 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.828701738344817 0.502120013192118 1.30084504235506 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 5 46 1106 7727 0.0045004500450045 0.00146284970071471 0.0104710615528963 0.99408207899138 0.992114126605487 0.995664176156987 0.0980392156862745 0.0326064895518909 0.21414498254568 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.759395392719553 0.234988635711236 1.90966703541653 NA NA NA NA NA NA 37 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.673C>T ccsA_c.673C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.684C>T ccsA_c.684C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.687C>A ccsA_c.687C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.696C>T ccsA_c.696C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 21.6259333410942 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.69G>A ccsA_c.69G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.-69G>T ccsA_c.-69G>T 2 upstream_gene_variant 619822 1 0 0 0 0 14 2460 21964 0 0 0.00149842073847528 0.999362999362999 0.998931451908832 0.999651703457902 0 0 0.231635761650116 NA NA NA 0 0 0.231635761650116 NA NA NA NA 1728 1832 False False 0 0 2.69356616691972 0 0 0.00149842073847528 0.999362999362999 0.998931451908832 0.999651703457902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin ccsA c.708C>T ccsA_c.708C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.714C>T ccsA_c.714C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.720C>T ccsA_c.720C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 37.2625869115887 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.729G>A ccsA_c.729G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 6 2456 21972 0.0016260162601626 0.000443206823318481 0.00415796841630328 0.999726999726999 0.999405888764937 0.999899807333004 0.4 0.121552258119827 0.737621923393055 NA NA NA NA NA NA NA NA NA NA NA NA False False 5.96416938110749 1.23687013477437 25.1657966311838 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 4 5 1107 7768 0.0036003600360036 0.000981821480890848 0.0091924849732633 0.999356747716454 0.998499507558406 0.999791105797204 0.444444444444444 0.136995662265166 0.787991493221131 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 5.6137308039747 1.11185366919088 26.1016683058683 NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.72G>A ccsA_c.72G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.732G>A ccsA_c.732G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.-76G>C ccsA_c.-76G>C 2 upstream_gene_variant 619815 1 18 2 16 6 16 2454 21962 0.0024390243902439 0.000895588528695574 0.00530111511191433 0.999271999271999 0.998818040931792 0.999583829243268 0.272727272727272 0.107289248370397 0.502221201266349 0.111111111111111 0.0137512156643644 0.347120438608672 0.111111111111111 0.0137512156643644 0.347120438608672 1.11868378158109 0.124691031343396 4.76297117933928 0.701166349585219 140 1832 False False 3.35605134474327 1.07445900806091 9.03858877263882 0.000814332247557003 9.86346319130786e-05 0.00293852082826415 0.999271999271999 0.998818040931792 0.999583829243268 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 2 3 5 3 1106 7770 0.0045004500450045 0.00146284970071471 0.0104710615528963 0.999614048629872 0.998872504682436 0.999920400475616 0.625 0.244863216366551 0.914766585862746 0.4 0.0527449505263169 0.853367200365326 0.4 0.0527449505263169 0.853367200365326 4.68354430379746 0.390670241849264 40.9671688448172 0.120279808569092 20 981 False False 0 0 0 0 0 0 0 11.7088607594936 2.27326178330418 75.4579518262254 0.00180505415162454 0.000218675234011011 0.00650512093107437 0.999614048629872 0.998872504682436 0.999920400475616 7 3) Uncertain significance No change no 1 +Amikacin ccsA c.771C>T ccsA_c.771C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.-77G>A ccsA_c.-77G>A 2 upstream_gene_variant 619814 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin ccsA c.-77G>T ccsA_c.-77G>T 2 upstream_gene_variant 619814 1 3 0 3 2 3 2458 21975 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.9998634998635 0.999601141012814 0.999971849505602 0.4 0.0527449505263169 0.853367200365326 0 0 0.707598226178713 0 0 0.707598226178713 0 0 21.6435212769845 1 662.5 1832 False False 5.96013018714402 0.497500621694734 52.0542994003282 0 0 0.00149963904330158 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 1109 7772 0.0018001800180018 0.000218084550259369 0.00648759665094944 0.99987134954329 0.999283416286792 0.999996742857744 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 272.193350776574 1 267 981 False False 0 0 0 0 0 0 0 14.0162308385933 0.72870395111684 822.225420011683 0 0 0.00332078545526824 0.99987134954329 0.999283416286792 0.999996742857744 9 3) Uncertain significance No change no 1 +Amikacin ccsA c.789C>G ccsA_c.789C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.78G>A ccsA_c.78G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 13.5427650126618 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.-79C>T ccsA_c.-79C>T 2 upstream_gene_variant 619812 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin ccsA c.819G>A ccsA_c.819G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 21.6259333410942 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 37.2625869115887 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.843G>A ccsA_c.843G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.-85G>A ccsA_c.-85G>A 2 upstream_gene_variant 619806 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin ccsA c.870C>A ccsA_c.870C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.879C>G ccsA_c.879C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.894C>T ccsA_c.894C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.-89G>A ccsA_c.-89G>A 2 upstream_gene_variant 619802 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 37.2625869115887 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 NA 3) Uncertain significance No change no 1 +Amikacin ccsA c.-89G>C ccsA_c.-89G>C 2 upstream_gene_variant 619802 NA 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1725 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Amikacin ccsA c.-90_-85delCGAGCG ccsA_c.-90_-85delCGAGCG 2 upstream_gene_variant 619800 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin ccsA c.906C>T ccsA_c.906C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.918T>C ccsA_c.918T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 37.2625869115887 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.924C>T ccsA_c.924C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.963G>C ccsA_c.963G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin ccsA c.-96C>A ccsA_c.-96C>A 2 upstream_gene_variant 619795 NA 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1727 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 947 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 1 3) Uncertain significance New Uncertain no 0 +Amikacin ccsA c.-96C>G ccsA_c.-96C>G 2 upstream_gene_variant 619795 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin ccsA c.-99C>T ccsA_c.-99C>T 2 upstream_gene_variant 619792 NA 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1722 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin ccsA p.Ala11Val ccsA_p.Ala11Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin ccsA p.Ala189Thr ccsA_p.Ala189Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 10 1 2450 21977 0.0040650406504065 0.00195101362065822 0.00746300821583156 0.9999544999545 0.999746516336938 0.999998848039248 0.909090909090909 0.587220083011617 0.997701027786185 0 0 0.975 0 0 0.975 0 0 347.957217790892 1 165 1832 False False 89.7020408163265 12.7454356113309 3802.11728419509 0 0 0.00150453213832349 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1110 7773 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 1 0.999525536566873 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 948 981 False False 0 0 0 0 0 0 0 Inf 0.179394825906045 Inf 0 0 0.00331779872508707 1 0.999525536566873 1 3 3) Uncertain significance No change no 1 +Amikacin ccsA p.Ala229Ser ccsA_p.Ala229Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 4 5 2456 21973 0.0016260162601626 0.000443206823318481 0.00415796841630328 0.999772499772499 0.99946917089695 0.999926127301238 0.444444444444444 0.136995662265166 0.787991493221131 0 0 0.707598226178713 0 0 0.521823750104981 0 0 21.6591682177597 1 165 1832 False False 7.15732899022801 1.41903679786966 33.2752823770963 0 0 0.00150085933084757 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin ccsA p.Ala248Val ccsA_p.Ala248Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin ccsA p.Ala281Glu ccsA_p.Ala281Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin ccsA p.Ala285dup ccsA_p.Ala285dup 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin ccsA p.Ala298Ser ccsA_p.Ala298Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin ccsA p.Ala33Val ccsA_p.Ala33Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin ccsA p.Ala48Val ccsA_p.Ala48Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin ccsA p.Ala55Val ccsA_p.Ala55Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1744 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin ccsA p.Arg131Cys ccsA_p.Arg131Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 18 3) Uncertain significance No change no 1 +Amikacin ccsA p.Arg199Cys ccsA_p.Arg199Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin ccsA p.Arg202Gly ccsA_p.Arg202Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin ccsA p.Arg217Gln ccsA_p.Arg217Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1745 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 950 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin ccsA p.Arg217Gly ccsA_p.Arg217Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 21.6259333410942 1 662.5 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin ccsA p.Arg217Trp ccsA_p.Arg217Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.22908065008664 Inf 0.100662902037809 42.5 1832 False False Inf 0.22908065008664 Inf 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1110 7773 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 1 0.999525536566873 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.179394825906045 Inf 0.125056280954525 25.5 981 False False 0 0 0 0 0 0 0 Inf 0.179394825906045 Inf 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 1 0.999525536566873 1 1 3) Uncertain significance No change no 1 +Amikacin ccsA p.Arg257Cys ccsA_p.Arg257Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 29 0 29 0 31 2460 21947 0 0 0.00149842073847528 0.998589498589498 0.997998498131125 0.999041437774243 0 0 0.11218874692237 0 0 0.119444869069502 0 0 0.11218874692237 0 0 1.21116098798163 0.1113195752834 61 1832 False False 0 0 1.1282699517541 0 0 0.00149842073847528 0.998589498589498 0.997998498131125 0.999041437774243 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 0 9 1111 7764 0 0 0.00331481736263177 0.998842145889618 0.997803175208698 0.999470423012169 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.336267116879942 0 0 3.54586915871032 0.61329084057404 55.5 981 False False 0 0 0 0 0 0 0 0 0 3.54586915871032 0 0 0.00331481736263177 0.998842145889618 0.997803175208698 0.999470423012169 61 3) Uncertain significance No change no 1 +Amikacin ccsA p.Arg288Gln ccsA_p.Arg288Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin ccsA p.Arg68Trp ccsA_p.Arg68Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin ccsA p.Asn296Ser ccsA_p.Asn296Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 1 2459 21977 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.9999544999545 0.999746516336938 0.999998848039248 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.229070226903647 Inf 0.100667021320129 55 1832 False False 8.93737291581943 0.113810496005924 697.318539256027 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Amikacin ccsA p.Asp226Asn ccsA_p.Asp226Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 1 8 2459 21970 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999635999635999 0.999282900840091 0.999842837798826 0.111111111111111 0.00280913674659921 0.482496514917337 0 0 0.4592581264399 0 0 0.369416647552819 0 0 7.59282850153241 1 662.5 1832 False False 1.11681577877185 0.0251588722809246 8.33607459248682 0 0 0.00149902964335061 0.999635999635999 0.999282900840091 0.999842837798826 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 1110 7771 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.999742699086581 0.999070852951501 0.999968838146642 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 271.914335788577 1 267 981 False False 0 0 0 0 0 0 0 3.50045045045045 0.0592795803100707 67.3732765257098 0 0 0.00331779872508707 0.999742699086581 0.999070852951501 0.999968838146642 5 3) Uncertain significance No change no 1 +Amikacin ccsA p.Glu35Gly ccsA_p.Glu35Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin ccsA p.Glu74Ala ccsA_p.Glu74Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 346.534733964433 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin ccsA p.Gly324Ser ccsA_p.Gly324Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin ccsA p.Gly43Arg ccsA_p.Gly43Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin ccsA p.Gly52Arg ccsA_p.Gly52Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin ccsA p.Gly79Ser ccsA_p.Gly79Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin ccsA p.Gly99Ala ccsA_p.Gly99Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1741 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 3) Uncertain significance No change no 1 +Amikacin ccsA p.Gly9Ser ccsA_p.Gly9Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin ccsA p.His5Asn ccsA_p.His5Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin ccsA p.His69Arg ccsA_p.His69Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1730 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin ccsA p.Ile123Ala ccsA_p.Ile123Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1720 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 945 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 6 3) Uncertain significance No change no 1 +Amikacin ccsA p.Ile245Met ccsA_p.Ile245Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1168 7628 1292 14350 0.474796747967479 0.454900239146164 0.49475333337829 0.652925652925653 0.64658942833857 0.65922140941044 0.132787630741246 0.125761613298901 0.140057828707923 NA NA NA 0 0 0.00048348028736104 NA NA NA NA NA NA False True 1.70067585447779 1.56233424120527 1.85104290098309 0 0 0.00285109773512598 0.652925652925653 0.64658942833857 0.65922140941044 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 617 3180 494 4593 0.555355535553555 0.525571129578631 0.584846061401843 0.590891547664994 0.579864647119326 0.601850246180677 0.162496707927311 0.150894236083457 0.174621128586288 NA NA NA 0 0 0.00115935241667755 NA NA NA NA NA NA False True 0 1 1 0 0 1 0 1.80396264609273 1.58620784003455 2.0519892207735 0 0 0.00743955579803412 0.590891547664994 0.579864647119326 0.601850246180677 6487 Not assoc w R 5) Not assoc w R No change yes 1 +Amikacin ccsA p.Ile245Val ccsA_p.Ile245Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 5 3) Uncertain significance New Uncertain no 0 +Amikacin ccsA p.Ile63Val ccsA_p.Ile63Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin ccsA p.Ile88Val ccsA_p.Ile88Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin ccsA p.Leu279Val ccsA_p.Leu279Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin ccsA p.Leu317Val ccsA_p.Leu317Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1733 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Amikacin ccsA p.Leu4Met ccsA_p.Leu4Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin ccsA p.Met164Ile ccsA_p.Met164Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1734 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin ccsA p.Phe186Ser ccsA_p.Phe186Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1746 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin ccsA p.Phe237Leu ccsA_p.Phe237Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Amikacin ccsA p.Phe237Ser ccsA_p.Phe237Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 47.551166952306 1 165 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin ccsA p.Phe242Leu ccsA_p.Phe242Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1747 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 952 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 6 3) Uncertain significance New Uncertain no 0 +Amikacin ccsA p.Phe305Val ccsA_p.Phe305Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin ccsA p.Phe308Leu ccsA_p.Phe308Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1729 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin ccsA p.Pro144Ser ccsA_p.Pro144Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 9 2460 21969 0 0 0.00149842073847528 0.999590499590499 0.999222783640785 0.999812733785825 0 0 0.336267116879942 0 0 0.4592581264399 0 0 0.336267116879942 0 0 7.58939472197272 1 165 1832 False False 0 0 4.52743474605681 0 0 0.00149842073847528 0.999590499590499 0.999222783640785 0.999812733785825 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 6 1111 7767 0 0 0.00331481736263177 0.999228097259745 0.998320655545558 0.999716674296114 0 0 0.4592581264399 0 0 0.602364635616474 0 0 0.4592581264399 0 0 10.6017544481422 1 267 981 False False 0 0 0 0 0 0 0 0 0 5.94541565066903 0 0 0.00331481736263177 0.999228097259745 0.998320655545558 0.999716674296114 8 3) Uncertain significance No change no 1 +Amikacin ccsA p.Pro165Leu ccsA_p.Pro165Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Amikacin ccsA p.Pro46Ser ccsA_p.Pro46Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1739 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin ccsA p.Pro61Leu ccsA_p.Pro61Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 2 2459 21976 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999908999909 0.999671315452743 0.999988979276808 0.333333333333333 0.00840375865961264 0.905700675949754 0.5 0.012579117093425 0.987420882906574 0.333333333333333 0.00840375865961264 0.905700675949754 8.93696624644164 0.113805317387077 697.287017600128 0.191203898368438 78.5 1832 False False 4.46848312322082 0.0757100934104112 86.0774363890598 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1110 7773 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 1 0.999525536566873 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.179394825906045 Inf 0.125056280954525 25.5 981 False False 0 0 0 0 0 0 0 Inf 0.179394825906045 Inf 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 1 0.999525536566873 1 28 3) Uncertain significance No change no 1 +Amikacin ccsA p.Pro71Leu ccsA_p.Pro71Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 7 3) Uncertain significance No change no 1 +Amikacin ccsA p.Ser193Asn ccsA_p.Ser193Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin ccsA p.Thr19Ala ccsA_p.Thr19Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin ccsA p.Thr19Pro ccsA_p.Thr19Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin ccsA p.Thr200Ile ccsA_p.Thr200Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1735 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin ccsA p.Thr224Pro ccsA_p.Thr224Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin ccsA p.Thr232Ala ccsA_p.Thr232Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin ccsA p.Thr266Ala ccsA_p.Thr266Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1737 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin ccsA p.Thr314Ala ccsA_p.Thr314Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1740 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin ccsA p.Thr3Met ccsA_p.Thr3Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1723 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Amikacin ccsA p.Thr56Ala ccsA_p.Thr56Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 47.5490114093265 1 662.5 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 951 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 6 3) Uncertain significance No change no 1 +Amikacin ccsA p.Thr60Ile ccsA_p.Thr60Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 47.551166952306 1 165 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 271.670627328402 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 1 3) Uncertain significance New Uncertain no 0 +Amikacin ccsA p.Tyr111His ccsA_p.Tyr111His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1726 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Amikacin ccsA p.Tyr134His ccsA_p.Tyr134His 2 missense_variant (see "Genomic_coordinates" sheet) 1 14 0 14 0 14 2460 21964 0 0 0.00149842073847528 0.999362999362999 0.998931451908832 0.999651703457902 0 0 0.231635761650116 0 0 0.231635761650116 0 0 0.231635761650116 0 0 2.69356616691972 0.386914489829204 92 1832 False False 0 0 2.69356616691972 0 0 0.00149842073847528 0.999362999362999 0.998931451908832 0.999651703457902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 12 0 12 0 12 1111 7761 0 0 0.00331481736263177 0.99845619451949 0.997304837007313 0.999202046759043 0 0 0.264648469397051 0 0 0.264648469397051 0 0 0.264648469397051 0 0 2.51816344117143 0.383112816423092 38 981 False False 0 0 0 0 0 0 0 0 0 2.51816344117143 0 0 0.00331481736263177 0.99845619451949 0.997304837007313 0.999202046759043 4 3) Uncertain significance No change no 1 +Amikacin ccsA p.Tyr85Asp ccsA_p.Tyr85Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1724 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 946 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin ccsA p.Tyr85Cys ccsA_p.Tyr85Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin ccsA p.Val143Phe ccsA_p.Val143Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 2460 21973 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 9.75275991328737 1 662.5 1832 False False 0 0 9.75275991328737 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance No change no 1 +Amikacin ccsA p.Val239Ile ccsA_p.Val239Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1742 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin ccsA p.Val244Met ccsA_p.Val244Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin ccsA p.Val27Ile ccsA_p.Val27Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 45 483 2415 21495 0.0182926829268292 0.013373310439526 0.0244011845715483 0.978023478023478 0.975998065532792 0.979921047867687 0.0852272727272727 0.0628433705244925 0.112379181311631 NA NA NA 0 0 0.00760834050890346 NA NA NA NA NA NA False True 0.829250414721654 0.595122193357465 1.13059951372542 0 0 0.00152632030294531 0.978023478023478 0.975998065532792 0.979921047867687 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 39 445 1072 7328 0.0351035103510351 0.0250788010356176 0.0476772267319015 0.942750546764441 0.937353336062053 0.947812688185577 0.0805785123966942 0.0579246941118379 0.108508539890735 NA NA NA 0 0 0.0082553526220801 NA NA NA NA NA NA False True 0 1 1 0 0 1 0 0.599094415562636 0.417685667152991 0.838063456855792 0 0 0.00343520502952392 0.942750546764441 0.937353336062053 0.947812688185577 86 Not assoc w R 5) Not assoc w R No change yes 1 +Amikacin ccsA p.Val27Leu ccsA_p.Val27Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 37.2625869115887 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 NA 3) Uncertain significance No change no 1 +Amikacin ccsA p.Val301Leu ccsA_p.Val301Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 346.534733964433 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Amikacin ccsA p.Val6Phe ccsA_p.Val6Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin ccsA p.Val76Ile ccsA_p.Val76Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 346.534733964433 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 949 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin eis c.1023C>G eis_c.1023C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.105C>G eis_c.105C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.1068G>A eis_c.1068G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 6 2460 21972 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.5904311186467 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.1086A>G eis_c.1086A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.-10G>A eis_c.-10G>A 1 upstream_gene_variant 2715342 1 328 18 310 22 369 2438 21609 0.00894308943089431 0.00561283016703731 0.0135088063431093 0.983210483210483 0.981423747355319 0.984867713695892 0.0562659846547314 0.0355938017111176 0.0839508286558621 0.0548780487804878 0.0328448603761972 0.0853463352523387 0.0465116279069767 0.0277953190799964 0.0725141788084455 0.514649765804863 0.300460907181793 0.828948405968991 0.0040150254358539 13 1832 False True 0.528441945617159 0.326474936837696 0.814309804634884 0.00732899022801302 0.00434923904351453 0.0115583200614416 0.983210483210483 0.981423747355319 0.984867713695892 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 246 11 235 15 278 1096 7495 0.0135013501350135 0.00757576336173372 0.0221707867273702 0.964235173034864 0.959864672887655 0.968252934304742 0.0511945392491467 0.0289327996170487 0.0830327367451869 0.0447154471544715 0.0225300776064709 0.0785983181186305 0.0380622837370242 0.0191510620734178 0.067082142178214 0.32010017083398 0.157113704509609 0.585940389534186 2.19140711804257e-05 4 981 True True 1 1 1 0 0 0 0 0.368984009872394 0.202979100353797 0.622315489453102 0.00993676603432701 0.00497053982787676 0.0177099197986808 0.964235173034864 0.959864672887655 0.968252934304742 205 5) Not assoc w R UP from Uncertain to NotAwR yes 4 +Amikacin eis c.-10G>C eis_c.-10G>C 1 upstream_gene_variant 2715342 1 72 2 70 5 82 2455 21896 0.00203252032520325 0.000660272864287742 0.00473679855039338 0.996268996268996 0.995370926245138 0.997031555253986 0.057471264367816 0.0189218901689693 0.129042456287925 0.0277777777777777 0.00338190032617324 0.0967672891134151 0.0238095238095238 0.00289656297053299 0.0833744665669055 0.254826883910387 0.0302512249028772 0.956648932194144 0.0460343563580752 22 1832 False False 0.543837862003874 0.171875424751421 1.32334020559482 0.000814000814000814 9.85944813843771e-05 0.00293732612068725 0.996268996268996 0.995370926245138 0.997031555253986 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 26 1 25 3 30 1108 7743 0.0027002700270027 0.000557207149395569 0.00787087587058421 0.996140486298726 0.994494851870603 0.997394533107523 0.0909090909090909 0.0191549429874049 0.243316350759155 0.0384615384615384 0.00097328789333503 0.196369646762539 0.032258064516129 0.000816370071846613 0.167021116230227 0.279530685920577 0.00680546462490049 1.71128727444157 0.242897707296586 35 981 False False 0 0 0 0 0 0 0 0.698826714801444 0.136258611882488 2.2529632353935 0.000901713255184851 2.28291424628202e-05 0.00501368162626477 0.996140486298726 0.994494851870603 0.997394533107523 15 3) Uncertain significance No change no 1 +Amikacin eis c.1119C>T eis_c.1119C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.1122G>A eis_c.1122G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 7 2460 21971 0 0 0.00149842073847528 0.999681499681499 0.999343878425726 0.999871937071415 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 6.20059597931892 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.1161C>T eis_c.1161C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 2459 21976 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999908999909 0.999671315452743 0.999988979276808 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 4.46848312322082 0.0757100934104112 86.0774363890598 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.1188C>T eis_c.1188C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.120G>T eis_c.120G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 37.2625869115887 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.-12C>A eis_c.-12C>A 1 upstream_gene_variant 2715344 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin eis c.12C>T eis_c.12C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.-12C>T eis_c.-12C>T 1 upstream_gene_variant 2715344 1 679 22 657 64 917 2396 21061 0.0260162601626016 0.0200920157154717 0.0331020165842349 0.958276458276458 0.955548848917679 0.960882001834215 0.0652395514780836 0.0506013531712327 0.0825491952674393 0.03240058910162 0.0204144387684738 0.0486455211239247 0.0234291799787007 0.0147398290884759 0.0352581399477112 0.294340135639561 0.182794096339666 0.450604901224736 1.41060925571752e-11 NA NA False True 0.613483395626662 0.466853493677098 0.794060526754483 0.00909842845326716 0.00571046966521893 0.0137429000340776 0.958276458276458 0.955548848917679 0.960882001834215 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 505 13 492 44 620 1067 7153 0.0396039603960396 0.0289211164878817 0.0528041071186955 0.920236716840344 0.91399060031248 0.92616552935329 0.0662650602409638 0.0485575863348981 0.0879397073039846 0.0257425742574257 0.0137764550877904 0.0436183164085735 0.0205371248025276 0.0109793722670409 0.0348630748896234 0.177134051096837 0.0933027928004305 0.307288864181444 9.3880089232822e-16 NA NA False True 1 1 1 0 0 1 0 0.475756568007981 0.339862982566225 0.651413583760483 0.012037037037037 0.00642435441725131 0.0204957432902697 0.920236716840344 0.91399060031248 0.92616552935329 201 Not assoc w R 5) Not assoc w R No change yes 1 +Amikacin eis c.-13A>G eis_c.-13A>G 1 upstream_gene_variant 2715345 1 1 0 1 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 346.534733964433 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 504 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 6 3) Uncertain significance No change no 1 +Amikacin eis c.144C>T eis_c.144C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.147C>G eis_c.147C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.-14C>T eis_c.-14C>T 1 upstream_gene_variant 2715346 1 200 72 128 90 213 2370 21765 0.0365853658536585 0.0295195707997734 0.0447799427649321 0.99030849030849 0.988923608099171 0.991561263179201 0.297029702970297 0.246137567750419 0.351941996835123 0.36 0.293504720891166 0.430713946018717 0.252631578947368 0.20323675927478 0.307250925765614 5.16574367088607 3.80239122453437 6.97107842983382 3.81258253742734e-23 2 1832 True False 3.88037083259048 2.98711504364983 5.00585675170386 0.0294840294840294 0.0231393794826734 0.0369876444874903 0.99030849030849 0.988923608099171 0.991561263179201 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 130 45 85 54 133 1057 7640 0.0486048604860486 0.0367211989444514 0.0629458098056343 0.982889489257686 0.979754325185258 0.985654603502098 0.288770053475935 0.224969885336181 0.35940346884589 0.346153846153846 0.26491897133426 0.434572843375494 0.252808988764044 0.190767717596075 0.323275969271617 3.8265902387445 2.58884212044165 5.58866787813344 4.37608513555674e-11 2 981 True False 0 0 0 0 0 0 0 2.93467822821007 2.08376593386854 4.08361610500455 0.0408348457350272 0.0299384140394166 0.0542610761465214 0.982889489257686 0.979754325185258 0.985654603502098 157 Assoc w R Marker of R WHO-endorsed gDST assay 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional Eis DOWN from AwR to AwRI yes WHO-end. gDST A 3 +Amikacin eis c.159C>A eis_c.159C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.-15C>G eis_c.-15C>G 1 upstream_gene_variant 2715347 1 16 0 16 1 22 2459 21956 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.998998998998999 0.998484862369405 0.999372575026909 0.0434782608695652 0.0011001686304415 0.21948660745348 0 0 0.205907214207822 0 0 0.154372512815574 0 0 2.31695745302018 0.396560764520266 97 1832 False False 0.40585603904026 0.00983315633476805 2.51317235882738 0 0 0.00149902964335061 0.998998998998999 0.998484862369405 0.999372575026909 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 12 0 12 0 16 1111 7757 0 0 0.00331481736263177 0.997941592692654 0.996659422164099 0.998822998929686 0 0 0.205907214207822 0 0 0.264648469397051 0 0 0.205907214207822 0 0 2.51686603816456 0.383132102284084 39 981 False False 0 0 0 0 0 0 0 0 0 1.81358991296359 0 0 0.00331481736263177 0.997941592692654 0.996659422164099 0.998822998929686 19 3) Uncertain significance No change no 1 +Amikacin eis c.-15C>T eis_c.-15C>T 1 upstream_gene_variant 2715347 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1189 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Amikacin eis c.15G>A eis_c.15G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.-16G>A eis_c.-16G>A 1 upstream_gene_variant 2715348 1 1 0 1 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 346.534733964433 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin eis c.-16G>C eis_c.-16G>C 1 upstream_gene_variant 2715348 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1223 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin eis c.177C>T eis_c.177C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.189G>A eis_c.189G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.198T>C eis_c.198T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.1G>T eis_c.1G>T 1 initiator_codon_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.-1T>G eis_c.-1T>G 1 upstream_gene_variant 2715333 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1213 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin eis c.207G>A eis_c.207G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.22908065008664 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 1110 7773 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 1 0.999525536566873 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.179394825906045 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.210G>C eis_c.210G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.210G>T eis_c.210G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 16 2460 21962 0 0 0.00149842073847528 0.999271999271999 0.998818040931792 0.999583829243268 0 0 0.205907214207822 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.31664784301595 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 6 1111 7767 0 0 0.00331481736263177 0.999228097259745 0.998320655545558 0.999716674296114 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 5.94541565066903 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.216T>C eis_c.216T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 4 2459 21974 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999817999817999 0.999534073414941 0.999950408920832 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.23403822692151 0.045345258756558 22.5860023464291 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 3 1110 7770 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.999614048629872 0.998872504682436 0.999920400475616 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.33333333333333 0.0444070764861474 29.0856116545381 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.-21C>T eis_c.-21C>T 1 upstream_gene_variant 2715353 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin eis c.234G>A eis_c.234G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 37.2625869115887 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.-23G>C eis_c.-23G>C 1 upstream_gene_variant 2715355 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin eis c.-23G>T eis_c.-23G>T 1 upstream_gene_variant 2715355 1 3 0 3 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 21.6259333410942 1 662.5 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 16.9345443329059 1 267 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 5 3) Uncertain significance No change no 1 +Amikacin eis c.246C>G eis_c.246C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.27C>T eis_c.27C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.291G>A eis_c.291G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.-2C>A eis_c.-2C>A 1 upstream_gene_variant 2715334 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1219 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 500 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin eis c.-300_-51del eis_c.-300_-51del 1 upstream_gene_variant 2715382 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 37.2625869115887 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 NA 3) Uncertain significance New Uncertain no 0 +Amikacin eis c.336C>T eis_c.336C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.339T>C eis_c.339T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 37.2625869115887 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.-33A>G eis_c.-33A>G 1 upstream_gene_variant 2715365 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin eis c.351A>C eis_c.351A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.369C>A eis_c.369C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.378C>T eis_c.378C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 4 45 2456 21933 0.0016260162601626 0.000443206823318481 0.00415796841630328 0.997952497952498 0.997261229652969 0.99850615794806 0.0816326530612244 0.0226908806430732 0.19601418347889 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.793811074918566 0.207169973261645 2.17991573214039 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 3 26 1108 7747 0.0027002700270027 0.000557207149395569 0.00787087587058421 0.996655088125562 0.995102743563572 0.997813864490847 0.103448275862068 0.0218637368298536 0.273515197892423 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.806755068036656 0.156011610644236 2.63915924023002 NA NA NA NA NA NA 72 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.-37G>T eis_c.-37G>T 1 upstream_gene_variant 2715369 1 154 10 144 17 158 2443 21820 0.00691056910569105 0.00403066294102424 0.0110415047085623 0.992810992810992 0.991603639126272 0.993885091201576 0.0971428571428571 0.0576134728355015 0.150976823479443 0.0649350649350649 0.0315754312579595 0.116174532956809 0.0595238095238095 0.0289099699172953 0.106740443518032 0.620252876699868 0.290821164071479 1.17611258529554 0.176979763773692 65 1832 False False 0.96099939377296 0.54508531094585 1.59169271212139 0.00407664084794129 0.00195658591100599 0.0074842685488573 0.992810992810992 0.991603639126272 0.993885091201576 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 121 8 113 12 122 1099 7651 0.0108010801080108 0.0055931822251036 0.0187912331484252 0.984304644281487 0.981288335255335 0.986949369301014 0.0895522388059701 0.0471323347493337 0.151204859680374 0.0661157024793388 0.0289740188147725 0.12612044292355 0.0615384615384615 0.026939696125929 0.117655233413849 0.492869624034721 0.207160472836512 1.00857546063796 0.0515514718709614 17 981 False False 0 0 0 0 0 0 0 0.684765584212175 0.34319840427894 1.24557188837053 0.007226738934056 0.00312500500835572 0.0141896610699272 0.984304644281487 0.981288335255335 0.986949369301014 328 3) Uncertain significance No change no 1 +Amikacin eis c.381C>G eis_c.381C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.-39A>C eis_c.-39A>C 1 upstream_gene_variant 2715371 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin eis c.418C>T eis_c.418C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.42G>C eis_c.42G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 4 28 2456 21950 0.0016260162601626 0.000443206823318481 0.00415796841630328 0.998725998725998 0.998159235769423 0.999153273664351 0.125 0.0351306531033114 0.289948420190755 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.27675663099115 0.325140455966952 3.65367153083822 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 2 8 1109 7765 0.0018001800180018 0.000218084550259369 0.00648759665094944 0.998970796346327 0.997973071099689 0.99955556151365 0.2 0.0252107263268333 0.556095462307641 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.75045085662759 0.180836667613198 8.78708905307725 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.-43A>G eis_c.-43A>G 1 upstream_gene_variant 2715375 1 3 0 3 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 21.6259333410942 1 662.5 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 37.2625869115887 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 11 3) Uncertain significance New Uncertain no 0 +Amikacin eis c.-44T>C eis_c.-44T>C 1 upstream_gene_variant 2715376 1 2 1 1 2 2 2458 21976 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.999908999909 0.999671315452743 0.999988979276808 0.5 0.067585986488543 0.932414013511457 0.5 0.012579117093425 0.987420882906574 0.333333333333333 0.00840375865961264 0.905700675949754 8.94060211554109 0.11385159866052 697.568851063792 0.191137698564744 67 1832 False False 8.94060211554109 0.647679042113151 123.448658884577 0.000406669377795852 1.02959242167344e-05 0.0022637116293895 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin eis c.45G>A eis_c.45G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.-50T>C eis_c.-50T>C 1 upstream_gene_variant 2715382 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin eis c.522G>A eis_c.522G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.537C>T eis_c.537C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.549C>T eis_c.549C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.-54G>A eis_c.-54G>A 1 upstream_gene_variant 2715386 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin eis c.57G>A eis_c.57G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.606A>C eis_c.606A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.-61A>C eis_c.-61A>C 1 upstream_gene_variant 2715393 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin eis c.-61A>G eis_c.-61A>G 1 upstream_gene_variant 2715393 1 1 1 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.22908065008664 Inf 0.100662902037809 42.5 1832 False False Inf 0.22908065008664 Inf 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin eis c.630A>C eis_c.630A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.660C>T eis_c.660C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 10 2460 21968 0 0 0.00149842073847528 0.999544999544999 0.999163397681526 0.999781788721324 0 0 0.30849710781876 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.98680916993403 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.663C>T eis_c.663C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.-66T>G eis_c.-66T>G 1 upstream_gene_variant 2715398 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin eis c.678C>T eis_c.678C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.679C>A eis_c.679C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.-67T>A eis_c.-67T>A 1 upstream_gene_variant 2715399 1 6 0 6 0 6 2460 21972 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 7.5904311186467 1 662.5 1832 False False 0 0 7.5904311186467 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin eis c.-69C>T eis_c.-69C>T 1 upstream_gene_variant 2715401 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Amikacin eis c.-6G>T eis_c.-6G>T 1 upstream_gene_variant 2715338 1 7 0 7 1 7 2459 21971 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999681499681499 0.999343878425726 0.999871937071415 0.125 0.0031597235312519 0.526509670875206 0 0 0.409616397225003 0 0 0.409616397225003 0 0 6.20311929300253 1 662.5 1832 False False 1.27641898565038 0.0283100041178698 9.94235653125396 0 0 0.00149902964335061 0.999681499681499 0.999343878425726 0.999871937071415 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 16.9345443329059 1 267 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 1 3) Uncertain significance No change no 1 +Amikacin eis c.705A>G eis_c.705A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.723C>A eis_c.723C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 37.2625869115887 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.762G>A eis_c.762G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.-79A>C eis_c.-79A>C 1 upstream_gene_variant 2715411 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance New Uncertain no 0 +Amikacin eis c.807C>T eis_c.807C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.813A>C eis_c.813A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.823T>C eis_c.823T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.831C>T eis_c.831C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 13.5427650126618 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 16.9345443329059 NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.840C>G eis_c.840C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.850C>T eis_c.850C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.864C>G eis_c.864C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.864C>T eis_c.864C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.870C>T eis_c.870C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.880C>T eis_c.880C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.894C>T eis_c.894C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.-8C>A eis_c.-8C>A 1 upstream_gene_variant 2715340 1 34 2 32 8 33 2452 21945 0.0032520325203252 0.00140501011649083 0.00639769284617963 0.998498498498498 0.997891973892477 0.998966217030968 0.195121951219512 0.0882061016628512 0.348665467451379 0.0588235294117647 0.00720491743904971 0.196773209335575 0.0571428571428571 0.00699676362830951 0.191571406345239 0.559364804241435 0.064911610912926 2.19485067191781 0.574712219169457 113 1832 False False 2.16965742251223 0.864767565981591 4.79760525927364 0.000814995925020374 9.87150311531988e-05 0.00294091316135219 0.998498498498498 0.997891973892477 0.998966217030968 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 13 0 13 4 13 1107 7760 0.0036003600360036 0.000981821480890848 0.0091924849732633 0.998327544062781 0.997141747487123 0.999109196577396 0.235294117647058 0.0681077404373566 0.49899327320458 0 0 0.24705263800047 0 0 0.24705263800047 0 0 2.3038781780126 0.391525871443391 41 981 False False 0 0 0 0 0 0 0 2.15690362031825 0.51135539841045 6.99708899258401 0 0 0.0033267750768979 0.998327544062781 0.997141747487123 0.999109196577396 6 3) Uncertain significance No change no 1 +Amikacin eis c.-8C>T eis_c.-8C>T 1 upstream_gene_variant 2715340 1 7 0 7 2 7 2458 21971 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.999681499681499 0.999343878425726 0.999871937071415 0.222222222222222 0.0281449734778982 0.600093573716312 0 0 0.409616397225003 0 0 0.409616397225003 0 0 6.205644661526 1 662.5 1832 False False 2.55387655469022 0.2587089419725 13.4183971176954 0 0 0.00149963904330158 0.999681499681499 0.999343878425726 0.999871937071415 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 37.2625869115887 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 4 3) Uncertain significance No change no 1 +Amikacin eis c.-8delC eis_c.-8delC 1 upstream_gene_variant 2715339 1 8 1 7 1 7 2459 21971 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999681499681499 0.999343878425726 0.999871937071415 0.125 0.0031597235312519 0.526509670875206 0.125 0.0031597235312519 0.526509670875206 0.125 0.0031597235312519 0.526509670875206 1.27641898565038 0.0283100041178698 9.94235653125396 0.572117661540397 111 1832 False False 1.27641898565038 0.0283100041178698 9.94235653125396 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999681499681499 0.999343878425726 0.999871937071415 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 1 5 1 5 1110 7768 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.999356747716454 0.998499507558406 0.999791105797204 0.166666666666666 0.00421074451448947 0.641234578997674 0.166666666666666 0.00421074451448947 0.641234578997674 0.166666666666666 0.00421074451448947 0.641234578997674 1.39963963963963 0.0295658812501739 12.524223051576 0.551486155582405 43 981 False False 0 0 0 0 0 0 0 1.39963963963963 0.0295658812501739 12.524223051576 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.999356747716454 0.998499507558406 0.999791105797204 4 3) Uncertain significance No change no 1 +Amikacin eis c.906G>C eis_c.906G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.909C>T eis_c.909C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.912A>G eis_c.912A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.921G>A eis_c.921G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.933T>G eis_c.933T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.996G>A eis_c.996G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin eis c.-9T>C eis_c.-9T>C 1 upstream_gene_variant 2715341 1 0 0 0 0 5 2460 21973 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1228 1832 False False 0 0 9.75275991328737 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 503 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 1 3) Uncertain significance No change no 1 +Amikacin eis deletion eis_deletion 1 feature_ablation (see "Genomic_coordinates" sheet) 0 0 0 0 1 4 2459 21974 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999817999817999 0.999534073414941 0.999950408920832 0.2 0.00505076337946806 0.716417936118089 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1199 1832 False False 2.23403822692151 0.045345258756558 22.5860023464291 0 0 0.00149902964335061 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 487 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 11 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations New Uncertain no B 0 +Amikacin eis LoF eis_LoF 1 LoF (see "Genomic_coordinates" sheet) 1 186 4 182 10 240 2450 21738 0.0040650406504065 0.00195101362065822 0.00746300821583156 0.989079989079989 0.987616632172049 0.990411736276166 0.04 0.0193454985052645 0.0723293554903805 0.021505376344086 0.00588984793816764 0.0541443002839604 0.0163934426229508 0.00448426390921294 0.0414394727744191 0.195003363982955 0.0525005419321653 0.508597687708632 4.13622685202147e-05 6 1832 True False 0.36969387755102 0.174800306560463 0.693105544539422 0.00162999185004074 0.000444290880723741 0.00416812166582756 0.989079989079989 0.987616632172049 0.990411736276166 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 68 3 65 7 92 1104 7681 0.0063006300630063 0.00253682126560623 0.0129383744241937 0.98816415798276 0.985503878263218 0.990448269211375 0.0707070707070707 0.0288990847755414 0.14026926582722 0.0441176470588235 0.00919219520278738 0.123562624331778 0.031578947368421 0.00656029175015836 0.0895224979869099 0.321112040133779 0.0644482836373285 0.983681165650882 0.0416607115120321 14 981 False False 0 0 0 0 0 0 0 0.529369486452426 0.206543574321372 1.1392776770933 0.002710027100271 0.000559221802810121 0.00789924214431003 0.98816415798276 0.985503878263218 0.990448269211375 NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations New Uncertain yes B 0 +Amikacin eis p.Ala134fs eis_p.Ala134fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1205 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations No change no B 1 +Amikacin eis p.Ala151Val eis_p.Ala151Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin eis p.Ala153Ser eis_p.Ala153Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin eis p.Ala206fs eis_p.Ala206fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1193 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations New Uncertain no B 0 +Amikacin eis p.Ala207Thr eis_p.Ala207Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1190 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 483 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 6 3) Uncertain significance No change no 1 +Amikacin eis p.Ala21Glu eis_p.Ala21Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin eis p.Ala22Gly eis_p.Ala22Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 2459 21976 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999908999909 0.999671315452743 0.999988979276808 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5725909264282 1 662.5 1832 False False 4.46848312322082 0.0757100934104112 86.0774363890598 0 0 0.00149902964335061 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Amikacin eis p.Ala243Val eis_p.Ala243Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 7 2460 21971 0 0 0.00149842073847528 0.999681499681499 0.999343878425726 0.999871937071415 0 0 0.409616397225003 0 0 0.521823750104981 0 0 0.409616397225003 0 0 9.75187230990876 1 662.5 1832 False False 0 0 6.20059597931892 0 0 0.00149842073847528 0.999681499681499 0.999343878425726 0.999871937071415 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 489 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 6 3) Uncertain significance No change no 1 +Amikacin eis p.Ala251Gly eis_p.Ala251Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 21.6259333410942 1 662.5 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 37.2625869115887 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 2 3) Uncertain significance No change no 1 +Amikacin eis p.Ala285Val eis_p.Ala285Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 6 3) Uncertain significance No change no 1 +Amikacin eis p.Ala304Val eis_p.Ala304Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 21.6249500611508 1 662.5 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 271.670627328402 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 NA 3) Uncertain significance No change no 1 +Amikacin eis p.Ala330Val eis_p.Ala330Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin eis p.Ala338Thr eis_p.Ala338Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin eis p.Ala370Ser eis_p.Ala370Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin eis p.Ala370Val eis_p.Ala370Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1224 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin eis p.Ala371Ser eis_p.Ala371Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Amikacin eis p.Ala62Val eis_p.Ala62Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin eis p.Ala86Val eis_p.Ala86Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 13.5427650126618 1 662.5 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin eis p.Ala99Val eis_p.Ala99Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin eis p.Arg106His eis_p.Arg106His 1 missense_variant (see "Genomic_coordinates" sheet) 1 27 2 25 2 37 2458 21941 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.998316498316498 0.997680253885098 0.998814391015244 0.0512820512820512 0.00627197209569041 0.173244781373605 0.074074074074074 0.00910007294230628 0.242898346845627 0.0512820512820512 0.00627197209569041 0.173244781373605 0.714109031733116 0.0819277320235821 2.86669960445821 1 662.5 1832 False False 0.482506102522375 0.0563108003463739 1.8725252867108 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.998316498316498 0.997680253885098 0.998814391015244 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 1 3 1 5 1110 7768 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.999356747716454 0.998499507558406 0.999791105797204 0.166666666666666 0.00421074451448947 0.641234578997674 0.25 0.00630946320970987 0.805879550316756 0.166666666666666 0.00421074451448947 0.641234578997674 2.33273273273273 0.0443956460917863 29.0781318803029 0.414101204143479 42 981 False False 0 0 0 0 0 0 0 1.39963963963963 0.0295658812501739 12.524223051576 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.999356747716454 0.998499507558406 0.999791105797204 59 3) Uncertain significance No change no 1 +Amikacin eis p.Arg212His eis_p.Arg212His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin eis p.Arg227Gln eis_p.Arg227Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 37.2625869115887 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 NA 3) Uncertain significance New Uncertain no 0 +Amikacin eis p.Arg254Gln eis_p.Arg254Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin eis p.Arg297Cys eis_p.Arg297Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin eis p.Arg339Gln eis_p.Arg339Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance New Uncertain no 0 +Amikacin eis p.Arg365fs eis_p.Arg365fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 346.534733964433 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations New Uncertain no B 0 +Amikacin eis p.Arg376Cys eis_p.Arg376Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin eis p.Arg37Gly eis_p.Arg37Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.22908065008664 Inf 0.100662902037809 42.5 1832 False False Inf 0.22908065008664 Inf 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1110 7773 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 1 0.999525536566873 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.179394825906045 Inf 0.125056280954525 25.5 981 False False 0 0 0 0 0 0 0 Inf 0.179394825906045 Inf 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 1 0.999525536566873 1 NA 3) Uncertain significance New Uncertain no 0 +Amikacin eis p.Arg49Cys eis_p.Arg49Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance No change no 1 +Amikacin eis p.Arg92Cys eis_p.Arg92Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 2 3) Uncertain significance No change no 1 +Amikacin eis p.Arg94Ser eis_p.Arg94Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin eis p.Asn373fs eis_p.Asn373fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1187 1832 False False Inf 0.22908065008664 Inf 0 0 0.00149902964335061 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1110 7773 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 1 0.999525536566873 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 480 981 False False 0 0 0 0 0 0 0 Inf 0.179394825906045 Inf 0 0 0.00331779872508707 1 0.999525536566873 1 NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations New Uncertain no B 0 +Amikacin eis p.Asp152Asn eis_p.Asp152Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1183 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin eis p.Asp152fs eis_p.Asp152fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1232 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 507 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations New Uncertain no B 0 +Amikacin eis p.Asp221Glu eis_p.Asp221Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin eis p.Asp26fs eis_p.Asp26fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1209 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 494 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations New Uncertain no B 0 +Amikacin eis p.Asp26Tyr eis_p.Asp26Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin eis p.Asp273Ala eis_p.Asp273Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin eis p.Asp281Gly eis_p.Asp281Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 346.534733964433 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 492 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance No change no 1 +Amikacin eis p.Asp325fs eis_p.Asp325fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations New Uncertain no B 0 +Amikacin eis p.Asp344fs eis_p.Asp344fs 1 frameshift (see "Genomic_coordinates" sheet) 1 3 0 3 2 6 2458 21972 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.999726999726999 0.999405888764937 0.999899807333004 0.25 0.0318540262499442 0.650855794412824 0 0 0.707598226178713 0 0 0.4592581264399 0 0 21.6405690127673 1 662.5 1832 False False 2.97965825874694 0.293935090708096 16.6698702493292 0 0 0.00149963904330158 0.999726999726999 0.999405888764937 0.999899807333004 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 2 4 1109 7769 0.0018001800180018 0.000218084550259369 0.00648759665094944 0.999485398173163 0.998682943858046 0.999859771090489 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.841886116991581 0 0 0.602364635616474 0 0 37.3201731495156 1 267 981 False False 0 0 0 0 0 0 0 3.50270513976555 0.316432630991257 24.4669088825335 0 0 0.00332078545526824 0.999485398173163 0.998682943858046 0.999859771090489 3 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations No change no B 1 +Amikacin eis p.Asp352Gly eis_p.Asp352Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 21.6259333410942 1 662.5 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 16.9345443329059 1 267 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 2 3) Uncertain significance No change no 1 +Amikacin eis p.Asp354Asn eis_p.Asp354Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin eis p.Asp354Glu eis_p.Asp354Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1188 1832 False False Inf 0.22908065008664 Inf 0 0 0.00149902964335061 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1110 7773 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 1 0.999525536566873 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 481 981 False False 0 0 0 0 0 0 0 Inf 0.179394825906045 Inf 0 0 0.00331779872508707 1 0.999525536566873 1 NA 3) Uncertain significance New Uncertain no 0 +Amikacin eis p.Cys6fs eis_p.Cys6fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1207 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 493 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations New Uncertain no B 0 +Amikacin eis p.Gln272* eis_p.Gln272* 1 stop_gained (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 21.6259333410942 1 662.5 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations No change no B 1 +Amikacin eis p.Glu103Lys eis_p.Glu103Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1194 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin eis p.Glu122Gly eis_p.Glu122Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 37.2625869115887 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 NA 3) Uncertain significance New Uncertain no 0 +Amikacin eis p.Glu170* eis_p.Glu170* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations New Uncertain no B 0 +Amikacin eis p.Glu176Ala eis_p.Glu176Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin eis p.Glu199Ala eis_p.Glu199Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.22908065008664 Inf 0.100662902037809 42.5 1832 False False Inf 0.22908065008664 Inf 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin eis p.Glu199Gly eis_p.Glu199Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin eis p.Glu313Asp eis_p.Glu313Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Amikacin eis p.Glu316fs eis_p.Glu316fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 5 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations No change no B 1 +Amikacin eis p.Glu348Asp eis_p.Glu348Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin eis p.Glu348Lys eis_p.Glu348Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 21.6259333410942 1 662.5 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin eis p.Glu401Asp eis_p.Glu401Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 2460 21973 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 9.75275991328737 1 662.5 1832 False False 0 0 9.75275991328737 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 25 3) Uncertain significance No change no 1 +Amikacin eis p.Glu74Asp eis_p.Glu74Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 21.6249500611508 1 662.5 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 1111 7769 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 16.9323809419784 1 267 981 False False 0 0 0 0 0 0 0 0 0 10.6044836876068 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 1 3) Uncertain significance New Uncertain no 0 +Amikacin eis p.Gly156Cys eis_p.Gly156Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin eis p.Gly159fs eis_p.Gly159fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1229 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 505 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations New Uncertain no B 0 +Amikacin eis p.Gly188Ala eis_p.Gly188Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 21.6259333410942 1 662.5 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin eis p.Gly210fs eis_p.Gly210fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1203 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations No change no B 1 +Amikacin eis p.Gly222Ala eis_p.Gly222Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 3) Uncertain significance No change no 1 +Amikacin eis p.Gly222Arg eis_p.Gly222Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1227 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 502 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 21 3) Uncertain significance No change no 1 +Amikacin eis p.Gly258Ser eis_p.Gly258Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin eis p.Gly309Asp eis_p.Gly309Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin eis p.Gly357Asp eis_p.Gly357Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin eis p.Gly357Ser eis_p.Gly357Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance New Uncertain no 0 +Amikacin eis p.Gly60Glu eis_p.Gly60Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1196 1832 False False Inf 0.22908065008664 Inf 0 0 0.00149902964335061 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin eis p.His105Tyr eis_p.His105Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin eis p.His150fs eis_p.His150fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 17 2460 21961 0 0 0.00149842073847528 0.999226499226499 0.99876183824676 0.999549344777619 0 0 0.195064322969093 NA NA NA 0 0 0.195064322969093 NA NA NA NA 1191 1832 False False 0 0 2.16489187000965 0 0 0.00149842073847528 0.999226499226499 0.99876183824676 0.999549344777619 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 13 1111 7760 0 0 0.00331481736263177 0.998327544062781 0.997141747487123 0.999109196577396 0 0 0.24705263800047 NA NA NA 0 0 0.24705263800047 NA NA NA NA 484 981 False False 0 0 0 0 0 0 0 0 0 2.29557234301212 0 0 0.00331481736263177 0.998327544062781 0.997141747487123 0.999109196577396 4 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations No change no B 1 +Amikacin eis p.His249Arg eis_p.His249Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin eis p.His270Gln eis_p.His270Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 11 0 11 1 13 2459 21965 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999408499408499 0.998988728376916 0.999685014453566 0.0714285714285714 0.00180678065912538 0.338684489931821 0 0 0.284914152918154 0 0 0.24705263800047 0 0 3.56151021182508 0.616654690790748 130 1832 False False 0.687114837175837 0.0161617294058642 4.57837625710886 0 0 0.00149902964335061 0.999408499408499 0.998988728376916 0.999685014453566 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 37.2577954991549 1 267 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 19 3) Uncertain significance No change no 1 +Amikacin eis p.His277Tyr eis_p.His277Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 2 3) Uncertain significance New Uncertain no 0 +Amikacin eis p.Ile267Thr eis_p.Ile267Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1197 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin eis p.Ile298fs eis_p.Ile298fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1216 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations New Uncertain no B 0 +Amikacin eis p.Ile333Val eis_p.Ile333Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1214 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 498 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 14 3) Uncertain significance New Uncertain no 0 +Amikacin eis p.Leu140Val eis_p.Leu140Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin eis p.Leu18Arg eis_p.Leu18Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1211 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 496 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 NA 3) Uncertain significance No change no 1 +Amikacin eis p.Leu18Pro eis_p.Leu18Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin eis p.Leu191fs eis_p.Leu191fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1215 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations No change no B 1 +Amikacin eis p.Leu200Val eis_p.Leu200Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin eis p.Leu201Arg eis_p.Leu201Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin eis p.Leu235Arg eis_p.Leu235Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 3 2 2457 21976 0.00121951219512195 0.00025156337591866 0.00355975660270706 0.999908999909 0.999671315452743 0.999988979276808 0.6 0.146632799634673 0.947255049473683 1 0.025 1 0.333333333333333 0.00840375865961264 0.905700675949754 Inf 0.229246182784464 Inf 0.100597528034705 30 1832 False False 13.4163614163614 1.53575955234231 160.561327730908 0.000406834825061025 1.03001129356897e-05 0.00226463172978561 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 482 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance No change no 1 +Amikacin eis p.Leu256Met eis_p.Leu256Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 2459 21976 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999908999909 0.999671315452743 0.999988979276808 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 346.674895666859 1 165 1832 False False 4.46848312322082 0.0757100934104112 86.0774363890598 0 0 0.00149902964335061 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 1110 7771 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.999742699086581 0.999070852951501 0.999968838146642 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 271.914335788577 1 267 981 False False 0 0 0 0 0 0 0 3.50045045045045 0.0592795803100707 67.3732765257098 0 0 0.00331779872508707 0.999742699086581 0.999070852951501 0.999968838146642 NA 3) Uncertain significance New Uncertain no 0 +Amikacin eis p.Leu256Pro eis_p.Leu256Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1220 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin eis p.Leu331Arg eis_p.Leu331Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 2459 21977 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.9999544999545 0.999746516336938 0.999998848039248 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1221 1832 False False 8.93737291581943 0.113810496005924 697.318539256027 0 0 0.00149902964335061 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin eis p.Leu361Phe eis_p.Leu361Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1198 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 486 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin eis p.Leu375fs eis_p.Leu375fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1233 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations New Uncertain no B 0 +Amikacin eis p.Leu375Ser eis_p.Leu375Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin eis p.Leu386Ile eis_p.Leu386Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1184 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Amikacin eis p.Leu77Pro eis_p.Leu77Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin eis p.Lys234Asn eis_p.Lys234Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1200 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 488 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin eis p.Lys234Glu eis_p.Lys234Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin eis p.Met1? eis_p.Met1? 1 start_lost (see "Genomic_coordinates" sheet) 1 0 0 0 0 7 2460 21971 0 0 0.00149842073847528 0.999681499681499 0.999343878425726 0.999871937071415 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1218 1832 False False 0 0 6.20059597931892 0 0 0.00149842073847528 0.999681499681499 0.999343878425726 0.999871937071415 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 1111 7768 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 499 981 False False 0 0 0 0 0 0 0 0 0 7.63947436138835 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 5 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations No change no B 1 +Amikacin eis p.Met100Val eis_p.Met100Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1217 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin eis p.Met16fs eis_p.Met16fs 1 frameshift (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 13.5427650126618 1 662.5 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 16.9345443329059 1 267 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 3 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations No change no B 1 +Amikacin eis p.Met351Val eis_p.Met351Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin eis p.Phe129Leu eis_p.Phe129Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 2459 21977 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.9999544999545 0.999746516336938 0.999998848039248 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 346.690584657338 1 662.5 1832 False False 8.93737291581943 0.113810496005924 697.318539256027 0 0 0.00149902964335061 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1110 7773 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 1 0.999525536566873 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 490 981 False False 0 0 0 0 0 0 0 Inf 0.179394825906045 Inf 0 0 0.00331779872508707 1 0.999525536566873 1 1 3) Uncertain significance No change no 1 +Amikacin eis p.Phe149Leu eis_p.Phe149Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 37.2625869115887 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 NA 3) Uncertain significance New Uncertain no 0 +Amikacin eis p.Phe149Val eis_p.Phe149Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 21.6259333410942 1 662.5 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 37.2625869115887 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 6 3) Uncertain significance New Uncertain no 0 +Amikacin eis p.Phe84Tyr eis_p.Phe84Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 2 2459 21976 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999908999909 0.999671315452743 0.999988979276808 0.333333333333333 0.00840375865961264 0.905700675949754 1 0.025 1 0.333333333333333 0.00840375865961264 0.905700675949754 Inf 0.229059803720654 Inf 0.100671140939597 56 1832 False False 4.46848312322082 0.0757100934104112 86.0774363890598 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin eis p.Pro114Leu eis_p.Pro114Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin eis p.Pro14_Val301delinsLeu eis_p.Pro14_Val301delinsLeu 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1186 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin eis p.Pro187Arg eis_p.Pro187Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin eis p.Pro193Ser eis_p.Pro193Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 2460 21973 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 9.75275991328737 1 662.5 1832 False False 0 0 9.75275991328737 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 14 3) Uncertain significance No change no 1 +Amikacin eis p.Pro208Leu eis_p.Pro208Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin eis p.Pro276Ser eis_p.Pro276Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 37.2625869115887 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 NA 3) Uncertain significance No change no 1 +Amikacin eis p.Pro302Gln eis_p.Pro302Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1230 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin eis p.Pro30His eis_p.Pro30His 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 21.6259333410942 1 662.5 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin eis p.Pro30Leu eis_p.Pro30Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Amikacin eis p.Pro342Leu eis_p.Pro342Leu 1 missense_variant (see "Genomic_coordinates" sheet) 2 11 0 11 1 11 2459 21967 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999499499499499 0.999104643231992 0.999750126319878 0.0833333333333333 0.00210759323186022 0.384796165150944 0 0 0.284914152918154 0 0 0.284914152918154 0 0 3.56183453556969 0.616650959510481 129 1832 False False 0.812118747458316 0.0188599260109937 5.5927738644815 0 0 0.00149902964335061 0.999499499499499 0.999104643231992 0.999750126319878 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 491 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 16 3) Uncertain significance No change no 1 +Amikacin eis p.Pro72Leu eis_p.Pro72Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin eis p.Pro78Ser eis_p.Pro78Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Amikacin eis p.Pro89Leu eis_p.Pro89Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin eis p.Ser162fs eis_p.Ser162fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1201 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations New Uncertain no B 0 +Amikacin eis p.Ser23Gly eis_p.Ser23Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin eis p.Ser318fs eis_p.Ser318fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations No change no B 1 +Amikacin eis p.Ser358Arg eis_p.Ser358Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin eis p.Ser367Pro eis_p.Ser367Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin eis p.Ser56Cys eis_p.Ser56Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin eis p.Ser56Pro eis_p.Ser56Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin eis p.Ser7Arg eis_p.Ser7Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1210 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 495 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin eis p.Ser83Thr eis_p.Ser83Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin eis p.Thr136Ser eis_p.Thr136Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin eis p.Thr231Ile eis_p.Thr231Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 13.5427650126618 1 662.5 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin eis p.Thr269fs eis_p.Thr269fs 1 frameshift (see "Genomic_coordinates" sheet) 1 166 4 162 5 167 2455 21811 0.00203252032520325 0.000660272864287742 0.00473679855039338 0.992401492401492 0.991163140715919 0.993506792227372 0.0290697674418604 0.00950488017597629 0.0665324125144748 0.0240963855421686 0.00660360752434987 0.0605446602828624 0.023391812865497 0.00640942602137679 0.0588068130418457 0.219365869603479 0.0589905285369226 0.573366865979994 0.000236470421624736 7 1832 False False 0.265997536495237 0.0851990738035844 0.634161942945498 0.0016266775111834 0.000443387132032367 0.0041596571880826 0.992401492401492 0.991163140715919 0.993506792227372 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 57 3 54 4 54 1107 7719 0.0036003600360036 0.000981821480890848 0.0091924849732633 0.993052875337707 0.99094511495494 0.994776922363167 0.0689655172413793 0.0191093118612043 0.167268132861663 0.0526315789473684 0.0109882558985872 0.146199064310523 0.0526315789473684 0.0109882558985872 0.146199064310523 0.387383318277627 0.0773421058080652 1.19734832444507 0.108721700518735 19 981 False False 0 0 0 0 0 0 0 0.516511091036836 0.135587185399425 1.40482233323618 0.0027027027027027 0.000557709450648201 0.0078779483224961 0.993052875337707 0.99094511495494 0.994776922363167 175 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations New Uncertain no B 0 +Amikacin eis p.Thr282Ile eis_p.Thr282Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin eis p.Thr287Ala eis_p.Thr287Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1231 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 506 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 21 3) Uncertain significance No change no 1 +Amikacin eis p.Thr2Ala eis_p.Thr2Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1234 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 508 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance New Uncertain no 0 +Amikacin eis p.Thr341Ile eis_p.Thr341Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1208 1832 False False Inf 0.22908065008664 Inf 0 0 0.00149902964335061 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin eis p.Thr38Ala eis_p.Thr38Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin eis p.Thr398Asn eis_p.Thr398Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 21.6259333410942 1 662.5 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Amikacin eis p.Thr4Pro eis_p.Thr4Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1222 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin eis p.Thr70Ala eis_p.Thr70Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 2460 21972 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 7.5904311186467 1 662.5 1832 False False 0 0 7.5904311186467 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 1111 7769 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 10.6044836876068 1 267 981 False False 0 0 0 0 0 0 0 0 0 10.6044836876068 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 71 3) Uncertain significance No change no 1 +Amikacin eis p.Thr90fs eis_p.Thr90fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1225 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations No change no B 1 +Amikacin eis p.Trp13Arg eis_p.Trp13Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1206 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin eis p.Trp182fs eis_p.Trp182fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1185 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations New Uncertain no B 0 +Amikacin eis p.Trp182* eis_p.Trp182* 1 stop_gained (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations No change no B 1 +Amikacin eis p.Trp253* eis_p.Trp253* 1 stop_gained (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1195 1832 False False Inf 0.22908065008664 Inf 0 0 0.00149902964335061 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations New Uncertain no B 0 +Amikacin eis p.Trp36Arg eis_p.Trp36Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 2 3 7 3 2453 21975 0.00284552845528455 0.00114479164591456 0.00585403416056955 0.9998634998635 0.999601141012814 0.999971849505602 0.7 0.347547149940002 0.933260488822265 0.4 0.0527449505263169 0.853367200365326 0.4 0.0527449505263169 0.853367200365326 5.97227884223399 0.498514427748525 52.1606684347814 0.08214138615406 29 1832 False False 20.902975947819 4.76722638696772 124.963139199826 0.000814663951120163 9.86748151560194e-05 0.00293971650809003 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 2 3 1109 7770 0.0018001800180018 0.000218084550259369 0.00648759665094944 0.999614048629872 0.998872504682436 0.999920400475616 0.4 0.0527449505263169 0.853367200365326 0 0 0.707598226178713 0 0 0.707598226178713 0 0 16.9648857231321 1 267 981 False False 0 0 0 0 0 0 0 4.67087466185752 0.389614743310331 40.8502933343974 0 0 0.00332078545526824 0.999614048629872 0.998872504682436 0.999920400475616 2 3) Uncertain significance No change no 1 +Amikacin eis p.Trp36* eis_p.Trp36* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations No change no B 1 +Amikacin eis p.Tyr226fs eis_p.Tyr226fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations New Uncertain no B 0 +Amikacin eis p.Val115Ala eis_p.Val115Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin eis p.Val163Ile eis_p.Val163Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 648 13 635 53 711 2407 21267 0.0215447154471544 0.0161791096494416 0.0280872296382952 0.967649467649467 0.965224868477025 0.969949323296242 0.0693717277486911 0.0523925712338657 0.0897608432893753 0.0200617283950617 0.0107242123000823 0.0340618484893262 0.0179558011049723 0.00959447448100952 0.0305092486744196 0.180883839457749 0.0956267027625954 0.312233467835427 6.77190669222192e-16 NA NA False True 0.658622267332095 0.486955713059478 0.874438645771719 0.00537190082644628 0.00286331826290043 0.0091685955359767 0.967649467649467 0.965224868477025 0.969949323296242 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 110 1 109 7 126 1104 7647 0.0063006300630063 0.00253682126560623 0.0129383744241937 0.98379004245465 0.980729887019851 0.986479178829886 0.0526315789473684 0.0214196802491291 0.105434728572376 0.00909090909090909 0.000230135405550292 0.0496111893119848 0.00787401574803149 0.000199332949321125 0.0430896736820098 0.0635470682090147 0.00159703499469156 0.362435890869158 1.37820214234657e-05 NA NA False True 0 1 1 0 0 1 0 0.384812801932367 0.151203926747067 0.819415977450519 0.00090497737556561 2.29117809458344e-05 0.00503179316804045 0.98379004245465 0.980729887019851 0.986479178829886 462 Not assoc w R 5) Not assoc w R No change yes 1 +Amikacin eis p.Val3_Thr4del eis_p.Val3_Thr4del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1212 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 497 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin eis p.Val301Gly eis_p.Val301Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1204 1832 False False Inf 0.22908065008664 Inf 0 0 0.00149902964335061 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin eis p.Val301Ile eis_p.Val301Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 2460 21973 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 13.5421472279808 1 662.5 1832 False False 0 0 9.75275991328737 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Amikacin eis p.Val314Leu eis_p.Val314Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 21 3) Uncertain significance No change no 1 +Amikacin eis p.Val396Ile eis_p.Val396Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin eis p.Val3Ala eis_p.Val3Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin eis p.Val40Met eis_p.Val40Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.22908065008664 Inf 0.100662902037809 42.5 1832 False False Inf 0.22908065008664 Inf 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1110 7773 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 1 0.999525536566873 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.179394825906045 Inf 0.125056280954525 25.5 981 False False 0 0 0 0 0 0 0 Inf 0.179394825906045 Inf 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 1 0.999525536566873 1 1 3) Uncertain significance New Uncertain no 0 +Amikacin eis p.Val47fs eis_p.Val47fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1202 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations New Uncertain no B 0 +Amikacin eis p.Val85Ala eis_p.Val85Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 2459 21977 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.9999544999545 0.999746516336938 0.999998848039248 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1192 1832 False False 8.93737291581943 0.113810496005924 697.318539256027 0 0 0.00149902964335061 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 1110 7772 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.99987134954329 0.999283416286792 0.999996742857744 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 485 981 False False 0 0 0 0 0 0 0 7.0018018018018 0.0891187877143753 547.10724479397 0 0 0.00331779872508707 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin eis p.Val85fs eis_p.Val85fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1226 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 501 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations New Uncertain no B 0 +Amikacin rrs n.1000G>A rrs_n.1000G>A 1 non_coding_transcript_exon_variant 1472845 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1536 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 793 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1001C>A rrs_n.1001C>A 1 non_coding_transcript_exon_variant 1472846 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1527 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 785 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin rrs n.1001C>G rrs_n.1001C>G 1 non_coding_transcript_exon_variant 1472846 1 2 1 1 1 1 2459 21977 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.9999544999545 0.999746516336938 0.999998848039248 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 8.93737291581943 0.113810496005924 697.318539256027 0.191196488852352 72.5 1832 False False 8.93737291581943 0.113810496005924 697.318539256027 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.1001C>T rrs_n.1001C>T 1 non_coding_transcript_exon_variant 1472846 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1260 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 531 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1002G>A rrs_n.1002G>A 1 non_coding_transcript_exon_variant 1472847 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1276 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 546 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1002G>C rrs_n.1002G>C 1 non_coding_transcript_exon_variant 1472847 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1578 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 834 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin rrs n.1002G>T rrs_n.1002G>T 1 non_coding_transcript_exon_variant 1472847 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1597 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 853 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1003T>A rrs_n.1003T>A 1 non_coding_transcript_exon_variant 1472848 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1285 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 555 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1003T>C rrs_n.1003T>C 1 non_coding_transcript_exon_variant 1472848 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1286 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 556 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1004C>G rrs_n.1004C>G 1 non_coding_transcript_exon_variant 1472849 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1610 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 867 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin rrs n.1005T>C rrs_n.1005T>C 1 non_coding_transcript_exon_variant 1472850 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1516 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 775 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance No change no 1 +Amikacin rrs n.1008A>C rrs_n.1008A>C 1 non_coding_transcript_exon_variant 1472853 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.-101_-100insG rrs_n.-101_-100insG 1 upstream_gene_variant 1471745 1 8 0 8 0 8 2460 21970 0 0 0.00149842073847528 0.999635999635999 0.999282900840091 0.999842837798826 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 5.2353912865109 1 165 1832 False False 0 0 5.2353912865109 0 0 0.00149842073847528 0.999635999635999 0.999282900840091 0.999842837798826 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 1111 7769 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 10.6044836876068 1 267 981 False False 0 0 0 0 0 0 0 0 0 10.6044836876068 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 2 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1010_1011insC rrs_n.1010_1011insC 1 non_coding_transcript_exon_variant 1472855 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1011T>C rrs_n.1011T>C 1 non_coding_transcript_exon_variant 1472856 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.1012A>G rrs_n.1012A>G 1 non_coding_transcript_exon_variant 1472857 1 1 0 1 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 346.534733964433 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 581 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 20 3) Uncertain significance No change no 1 +Amikacin rrs n.1013G>T rrs_n.1013G>T 1 non_coding_transcript_exon_variant 1472858 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1475 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 738 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 2 3) Uncertain significance No change no 1 +Amikacin rrs n.1014_1015insA rrs_n.1014_1015insA 1 non_coding_transcript_exon_variant 1472859 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1261 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 532 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1014G>T rrs_n.1014G>T 1 non_coding_transcript_exon_variant 1472859 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1321 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 590 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1015C>G rrs_n.1015C>G 1 non_coding_transcript_exon_variant 1472860 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1374 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 639 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin rrs n.1015C>T rrs_n.1015C>T 1 non_coding_transcript_exon_variant 1472860 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1364 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 629 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1016G>A rrs_n.1016G>A 1 non_coding_transcript_exon_variant 1472861 1 1 0 1 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 346.534733964433 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 630 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin rrs n.1016G>C rrs_n.1016G>C 1 non_coding_transcript_exon_variant 1472861 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Amikacin rrs n.1016G>T rrs_n.1016G>T 1 non_coding_transcript_exon_variant 1472861 1 1 0 1 1 1 2459 21977 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.9999544999545 0.999746516336938 0.999998848039248 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 346.690584657338 1 662.5 1832 False False 8.93737291581943 0.113810496005924 697.318539256027 0 0 0.00149902964335061 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin rrs n.1017T>C rrs_n.1017T>C 1 non_coding_transcript_exon_variant 1472862 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1365 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 631 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1018T>C rrs_n.1018T>C 1 non_coding_transcript_exon_variant 1472863 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1579 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 835 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1021C>T rrs_n.1021C>T 1 non_coding_transcript_exon_variant 1472866 1 9 0 9 0 11 2460 21967 0 0 0.00149842073847528 0.999499499499499 0.999104643231992 0.999750126319878 0 0 0.284914152918154 0 0 0.336267116879942 0 0 0.284914152918154 0 0 4.52702260214529 0.612222838582932 115 1832 False False 0 0 3.56038548490505 0 0 0.00149842073847528 0.999499499499499 0.999104643231992 0.999750126319878 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 699 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 5 3) Uncertain significance No change no 1 +Amikacin rrs n.1022_1032delTTGTGGCCTGTinsCTTCGGGGGACAAA rrs_n.1022_1032delTTGTGGCCTGTinsCTTCGGGGGACAAA 1 non_coding_transcript_exon_variant 1472867 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1476 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1022_1032delTTGTGGCCTGTinsCTTCGGGGGCAGA rrs_n.1022_1032delTTGTGGCCTGTinsCTTCGGGGGCAGA 1 non_coding_transcript_exon_variant 1472867 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1553 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1024_1032delGTGGCCTGTinsCGGGGGCAGA rrs_n.1024_1032delGTGGCCTGTinsCGGGGGCAGA 1 non_coding_transcript_exon_variant 1472869 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1517 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 776 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1027G>A rrs_n.1027G>A 1 non_coding_transcript_exon_variant 1472872 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Amikacin rrs n.1028C>A rrs_n.1028C>A 1 non_coding_transcript_exon_variant 1472873 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.1028C>T rrs_n.1028C>T 1 non_coding_transcript_exon_variant 1472873 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1537 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 794 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 1 3) Uncertain significance No change no 1 +Amikacin rrs n.1030T>G rrs_n.1030T>G 1 non_coding_transcript_exon_variant 1472875 1 1 0 1 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 346.503368577436 1 662.5 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 854 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 2 3) Uncertain significance No change no 1 +Amikacin rrs n.1035_1036insA rrs_n.1035_1036insA 1 non_coding_transcript_exon_variant 1472880 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1406 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 669 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1035G>A rrs_n.1035G>A 1 non_coding_transcript_exon_variant 1472880 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1437 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 700 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 2 3) Uncertain significance No change no 1 +Amikacin rrs n.1042G>C rrs_n.1042G>C 1 non_coding_transcript_exon_variant 1472887 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1262 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 533 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 23 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1050C>T rrs_n.1050C>T 1 non_coding_transcript_exon_variant 1472895 NA 0 0 0 2 38 2458 21940 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.998270998270998 0.997627574582383 0.998776173913035 0.05 0.00611364659935083 0.169196863959417 NA NA NA 0 0 0.0925127614158782 NA NA NA NA 1634 1832 False True 0.469787161149415 0.0548781370690863 1.81981740573229 0 0 0.00149963904330158 0.998270998270998 0.997627574582383 0.998776173913035 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 1 32 1110 7741 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.995883185385308 0.994193213278967 0.997182448944178 0.0303030303030303 0.000766912075048109 0.157593972272496 NA NA NA 0 0 0.108881160679352 NA NA NA NA 889 981 False True 1 1 1 0 0 0 0 0.217933558558558 0.00535112542930039 1.30754182664099 0 0 0.00331779872508707 0.995883185385308 0.994193213278967 0.997182448944178 299 5) Not assoc w R New NotAwR yes 5 +Amikacin rrs n.1058A>G rrs_n.1058A>G 1 non_coding_transcript_exon_variant 1472903 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.1062C>T rrs_n.1062C>T 1 non_coding_transcript_exon_variant 1472907 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.1067C>T rrs_n.1067C>T 1 non_coding_transcript_exon_variant 1472912 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1301 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1072G>A rrs_n.1072G>A 1 non_coding_transcript_exon_variant 1472917 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1287 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1077dupT rrs_n.1077dupT 1 non_coding_transcript_exon_variant 1472920 1 4 0 4 1 4 2459 21974 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999817999817999 0.999534073414941 0.999950408920832 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 13.5482881491524 1 662.5 1832 False False 2.23403822692151 0.045345258756558 22.5860023464291 0 0 0.00149902964335061 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 1110 7771 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.999742699086581 0.999070852951501 0.999968838146642 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 37.2961498596314 1 267 981 False False 0 0 0 0 0 0 0 3.50045045045045 0.0592795803100707 67.3732765257098 0 0 0.00331779872508707 0.999742699086581 0.999070852951501 0.999968838146642 NA 3) Uncertain significance No change no 1 +Amikacin rrs n.1078G>A rrs_n.1078G>A 1 non_coding_transcript_exon_variant 1472923 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1598 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 855 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1079G>A rrs_n.1079G>A 1 non_coding_transcript_exon_variant 1472924 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance No change no 1 +Amikacin rrs n.1089C>A rrs_n.1089C>A 1 non_coding_transcript_exon_variant 1472934 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1554 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 810 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1089C>T rrs_n.1089C>T 1 non_coding_transcript_exon_variant 1472934 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1538 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 795 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1090G>A rrs_n.1090G>A 1 non_coding_transcript_exon_variant 1472935 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1096A>G rrs_n.1096A>G 1 non_coding_transcript_exon_variant 1472941 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1099G>A rrs_n.1099G>A 1 non_coding_transcript_exon_variant 1472944 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1107_1118dupTGTCTCATGTTG rrs_n.1107_1118dupTGTCTCATGTTG 1 non_coding_transcript_exon_variant 1472951 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1107T>C rrs_n.1107T>C 1 non_coding_transcript_exon_variant 1472952 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1407 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 670 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 53 3) Uncertain significance No change no 1 +Amikacin rrs n.1108_1109insA rrs_n.1108_1109insA 1 non_coding_transcript_exon_variant 1472953 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1387 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 652 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1108G>A rrs_n.1108G>A 1 non_coding_transcript_exon_variant 1472953 1 1 0 1 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 346.519051274799 1 662.5 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 777 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 5 3) Uncertain significance No change no 1 +Amikacin rrs n.1109T>A rrs_n.1109T>A 1 non_coding_transcript_exon_variant 1472954 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1277 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 547 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1109T>C rrs_n.1109T>C 1 non_coding_transcript_exon_variant 1472954 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 36 3) Uncertain significance No change no 1 +Amikacin rrs n.1110C>T rrs_n.1110C>T 1 non_coding_transcript_exon_variant 1472955 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1302 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 570 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 54 3) Uncertain significance No change no 1 +Amikacin rrs n.1111T>C rrs_n.1111T>C 1 non_coding_transcript_exon_variant 1472956 1 0 0 0 0 7 2460 21971 0 0 0.00149842073847528 0.999681499681499 0.999343878425726 0.999871937071415 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1352 1832 False False 0 0 6.20059597931892 0 0 0.00149842073847528 0.999681499681499 0.999343878425726 0.999871937071415 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 1111 7767 0 0 0.00331481736263177 0.999228097259745 0.998320655545558 0.999716674296114 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 619 981 False False 0 0 0 0 0 0 0 0 0 5.94541565066903 0 0 0.00331481736263177 0.999228097259745 0.998320655545558 0.999716674296114 75 3) Uncertain significance No change no 1 +Amikacin rrs n.1112_1114delCATinsTA rrs_n.1112_1114delCATinsTA 1 non_coding_transcript_exon_variant 1472957 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1375 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 640 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1112C>T rrs_n.1112C>T 1 non_coding_transcript_exon_variant 1472957 1 4 0 4 0 10 2460 21968 0 0 0.00149842073847528 0.999544999544999 0.999163397681526 0.999781788721324 0 0 0.30849710781876 0 0 0.602364635616474 0 0 0.30849710781876 0 0 13.5390583059246 1 662.5 1832 False False 0 0 3.98680916993403 0 0 0.00149842073847528 0.999544999544999 0.999163397681526 0.999781788721324 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 9 1111 7764 0 0 0.00331481736263177 0.998842145889618 0.997803175208698 0.999470423012169 0 0 0.336267116879942 0 0 0.602364635616474 0 0 0.336267116879942 0 0 10.5976605887743 1 75.5 981 False False 0 0 0 0 0 0 0 0 0 3.54586915871032 0 0 0.00331481736263177 0.998842145889618 0.997803175208698 0.999470423012169 76 3) Uncertain significance No change no 1 +Amikacin rrs n.1113A>G rrs_n.1113A>G 1 non_coding_transcript_exon_variant 1472958 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1353 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 620 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 8 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1113A>T rrs_n.1113A>T 1 non_coding_transcript_exon_variant 1472958 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1458 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 719 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1114T>A rrs_n.1114T>A 1 non_coding_transcript_exon_variant 1472959 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1459 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 720 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1124A>G rrs_n.1124A>G 1 non_coding_transcript_exon_variant 1472969 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1622 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 877 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 5 3) Uncertain significance No change no 1 +Amikacin rrs n.1125_1132delCGTAATGGinsTTCAGT rrs_n.1125_1132delCGTAATGGinsTTCAGT 1 non_coding_transcript_exon_variant 1472970 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1438 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 701 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1125C>A rrs_n.1125C>A 1 non_coding_transcript_exon_variant 1472970 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1313 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 582 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1125C>G rrs_n.1125C>G 1 non_coding_transcript_exon_variant 1472970 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1388 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 653 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 2 3) Uncertain significance No change no 1 +Amikacin rrs n.1128A>G rrs_n.1128A>G 1 non_coding_transcript_exon_variant 1472973 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1623 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 878 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 39 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1128A>T rrs_n.1128A>T 1 non_coding_transcript_exon_variant 1472973 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1389 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 654 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 87 3) Uncertain significance No change no 1 +Amikacin rrs n.1132G>C rrs_n.1132G>C 1 non_coding_transcript_exon_variant 1472977 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1408 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 671 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 3 3) Uncertain significance No change no 1 +Amikacin rrs n.1133T>C rrs_n.1133T>C 1 non_coding_transcript_exon_variant 1472978 1 1 0 1 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 346.519051274799 1 662.5 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 721 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 6 3) Uncertain significance No change no 1 +Amikacin rrs n.1137G>C rrs_n.1137G>C 1 non_coding_transcript_exon_variant 1472982 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1366 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 632 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1141C>T rrs_n.1141C>T 1 non_coding_transcript_exon_variant 1472986 1 10 0 10 0 11 2460 21967 0 0 0.00149842073847528 0.999499499499499 0.999104643231992 0.999750126319878 0 0 0.284914152918154 0 0 0.30849710781876 0 0 0.284914152918154 0 0 3.98662760843631 0.612510233731959 125 1832 False False 0 0 3.56038548490505 0 0 0.00149842073847528 0.999499499499499 0.999104643231992 0.999750126319878 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin rrs n.1142G>A rrs_n.1142G>A 1 non_coding_transcript_exon_variant 1472987 1 0 0 0 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1477 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1111 7769 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 739 981 False False 0 0 0 0 0 0 0 0 0 10.6044836876068 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 60 3) Uncertain significance No change no 1 +Amikacin rrs n.1142G>T rrs_n.1142G>T 1 non_coding_transcript_exon_variant 1472987 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1580 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 836 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1143T>A rrs_n.1143T>A 1 non_coding_transcript_exon_variant 1472988 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1599 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 856 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1143T>C rrs_n.1143T>C 1 non_coding_transcript_exon_variant 1472988 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1460 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 722 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 9 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1144G>A rrs_n.1144G>A 1 non_coding_transcript_exon_variant 1472989 1 0 0 0 0 5 2460 21973 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1478 1832 False False 0 0 9.75275991328737 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 1111 7768 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 740 981 False False 0 0 0 0 0 0 0 0 0 7.63947436138835 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 48 3) Uncertain significance No change no 1 +Amikacin rrs n.1145A>G rrs_n.1145A>G 1 non_coding_transcript_exon_variant 1472990 NA 0 0 0 0 7 2460 21971 0 0 0.00149842073847528 0.999681499681499 0.999343878425726 0.999871937071415 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1479 1832 False True 0 0 6.20059597931892 0 0 0.00149842073847528 0.999681499681499 0.999343878425726 0.999871937071415 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 7 1111 7766 0 0 0.00331481736263177 0.999099446803036 0.998145402056424 0.999637856686565 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 741 981 False True 0 1 1 0 0 0 0 0 0 4.85661817639599 0 0 0.00331481736263177 0.999099446803036 0.998145402056424 0.999637856686565 75 5) Not assoc w R UP from Uncertain to NotAwR yes 4 +Amikacin rrs n.1147A>T rrs_n.1147A>T 1 non_coding_transcript_exon_variant 1472992 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1390 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 655 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1148_1149dupGA rrs_n.1148_1149dupGA 1 non_coding_transcript_exon_variant 1472988 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin rrs n.1148G>A rrs_n.1148G>A 1 non_coding_transcript_exon_variant 1472993 1 5 0 5 0 5 2460 21973 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 9.75275991328737 1 662.5 1832 False False 0 0 9.75275991328737 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 17 3) Uncertain significance No change no 1 +Amikacin rrs n.1151T>C rrs_n.1151T>C 1 non_coding_transcript_exon_variant 1472996 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1539 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 796 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 15 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1153C>T rrs_n.1153C>T 1 non_coding_transcript_exon_variant 1472998 1 8 0 8 0 8 2460 21970 0 0 0.00149842073847528 0.999635999635999 0.999282900840091 0.999842837798826 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 5.2353912865109 1 165 1832 False False 0 0 5.2353912865109 0 0 0.00149842073847528 0.999635999635999 0.999282900840091 0.999842837798826 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.1157G>T rrs_n.1157G>T 1 non_coding_transcript_exon_variant 1473002 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1245 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 519 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 4 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1159T>A rrs_n.1159T>A 1 non_coding_transcript_exon_variant 1473004 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1391 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 656 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 2 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.115A>G rrs_n.115A>G 1 non_coding_transcript_exon_variant 1471960 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1528 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.1161A>C rrs_n.1161A>C 1 non_coding_transcript_exon_variant 1473006 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1288 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1162A>C rrs_n.1162A>C 1 non_coding_transcript_exon_variant 1473007 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1586 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1163C>A rrs_n.1163C>A 1 non_coding_transcript_exon_variant 1473008 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1336 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 604 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1164T>A rrs_n.1164T>A 1 non_coding_transcript_exon_variant 1473009 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.1164T>C rrs_n.1164T>C 1 non_coding_transcript_exon_variant 1473009 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1322 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 591 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1166G>A rrs_n.1166G>A 1 non_coding_transcript_exon_variant 1473011 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1167G>A rrs_n.1167G>A 1 non_coding_transcript_exon_variant 1473012 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.116C>T rrs_n.116C>T 1 non_coding_transcript_exon_variant 1471961 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.1171A>C rrs_n.1171A>C 1 non_coding_transcript_exon_variant 1473016 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.1175dupT rrs_n.1175dupT 1 non_coding_transcript_exon_variant 1473019 1 1 0 1 1 1 2459 21977 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.9999544999545 0.999746516336938 0.999998848039248 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 346.690584657338 1 662.5 1832 False False 8.93737291581943 0.113810496005924 697.318539256027 0 0 0.00149902964335061 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 1110 7772 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.99987134954329 0.999283416286792 0.999996742857744 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 271.949173528644 1 75.5 981 False False 0 0 0 0 0 0 0 7.0018018018018 0.0891187877143753 547.10724479397 0 0 0.00331779872508707 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1175T>C rrs_n.1175T>C 1 non_coding_transcript_exon_variant 1473020 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1581 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 837 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 7 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1176G>A rrs_n.1176G>A 1 non_coding_transcript_exon_variant 1473021 1 5 0 5 0 6 2460 21972 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 9.75231611160222 1 662.5 1832 False False 0 0 7.5904311186467 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Amikacin rrs n.-117delT rrs_n.-117delT 1 upstream_gene_variant 1471728 1 2 0 2 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 47.551166952306 1 165 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1180A>G rrs_n.1180A>G 1 non_coding_transcript_exon_variant 1473025 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1181T>C rrs_n.1181T>C 1 non_coding_transcript_exon_variant 1473026 1 0 0 0 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1314 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1111 7769 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 583 981 False False 0 0 0 0 0 0 0 0 0 10.6044836876068 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 3 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1184C>T rrs_n.1184C>T 1 non_coding_transcript_exon_variant 1473029 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1190G>A rrs_n.1190G>A 1 non_coding_transcript_exon_variant 1473035 NA 0 0 0 2 37 2458 21941 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.998316498316498 0.997680253885098 0.998814391015244 0.0512820512820512 0.00627197209569041 0.173244781373605 NA NA NA 0 0 0.0948905874149899 NA NA NA NA 1392 1832 False True 0.482506102522375 0.0563108003463739 1.8725252867108 0 0 0.00149963904330158 0.998316498316498 0.997680253885098 0.998814391015244 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 1 33 1110 7740 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.995754534928599 0.994042908633278 0.997075869271829 0.0294117647058823 0.00074436423469026 0.153267669560317 NA NA NA 0 0 0.105762810074579 NA NA NA NA 657 981 False True 0 1 1 0 0 0 0 0.211302211302211 0.00519312755327267 1.26498474807912 0 0 0.00331779872508707 0.995754534928599 0.994042908633278 0.997075869271829 290 5) Not assoc w R UP from Uncertain to NotAwR yes 4 +Amikacin rrs n.1191T>C rrs_n.1191T>C 1 non_coding_transcript_exon_variant 1473036 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.1198G>A rrs_n.1198G>A 1 non_coding_transcript_exon_variant 1473043 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1376 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 641 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1199C>G rrs_n.1199C>G 1 non_coding_transcript_exon_variant 1473044 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1529 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 786 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 22 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1199C>T rrs_n.1199C>T 1 non_coding_transcript_exon_variant 1473044 1 1 0 1 2 1 2458 21977 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.9999544999545 0.999746516336938 0.999998848039248 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 346.830866100726 1 165 1832 False False 17.8820179007323 0.930367849464557 1047.07427525324 0 0 0.00149963904330158 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 1109 7773 0.0018001800180018 0.000218084550259369 0.00648759665094944 1 0.999525536566873 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 838 981 False False 0 0 0 0 0 0 0 Inf 1.31458832505494 Inf 0 0 0.00332078545526824 1 0.999525536566873 1 1 3) Uncertain significance No change no 1 +Amikacin rrs n.-119C>T rrs_n.-119C>T 1 upstream_gene_variant 1471727 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.11A>C rrs_n.11A>C 1 non_coding_transcript_exon_variant 1471856 0 0 0 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1518 1832 False False Inf 0.22908065008664 Inf 0 0 0.00149902964335061 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1110 7773 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 1 0.999525536566873 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 778 981 False False 0 0 0 0 0 0 0 Inf 0.179394825906045 Inf 0 0 0.00331779872508707 1 0.999525536566873 1 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1208T>A rrs_n.1208T>A 1 non_coding_transcript_exon_variant 1473053 NA 0 0 0 2 14 2458 21964 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.999362999362999 0.998931451908832 0.999651703457902 0.125 0.0155136038154138 0.383476236849263 NA NA NA 0 0 0.231635761650116 NA NA NA NA 1315 1832 False True 1.27653144252005 0.14074898208514 5.56220221272253 0 0 0.00149963904330158 0.999362999362999 0.998931451908832 0.999651703457902 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 1 12 1110 7761 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.99845619451949 0.997304837007313 0.999202046759043 0.0769230769230769 0.00194562849734675 0.360297435267877 NA NA NA 0 0 0.264648469397051 NA NA NA NA 584 981 False True 1 1 1 0 0 0 0 0.582657657657657 0.0136211353314299 3.94507356448373 0 0 0.00331779872508707 0.99845619451949 0.997304837007313 0.999202046759043 93 5) Not assoc w R New NotAwR yes 5 +Amikacin rrs n.1208T>C rrs_n.1208T>C 1 non_coding_transcript_exon_variant 1473053 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1587 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Amikacin rrs n.1208T>G rrs_n.1208T>G 1 non_coding_transcript_exon_variant 1473053 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 25 3) Uncertain significance No change no 1 +Amikacin rrs n.1210C>T rrs_n.1210C>T 1 non_coding_transcript_exon_variant 1473055 1 0 0 0 0 8 2460 21970 0 0 0.00149842073847528 0.999635999635999 0.999282900840091 0.999842837798826 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1600 1832 False False 0 0 5.2353912865109 0 0 0.00149842073847528 0.999635999635999 0.999282900840091 0.999842837798826 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 8 1111 7765 0 0 0.00331481736263177 0.998970796346327 0.997973071099689 0.99955556151365 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 857 981 False False 0 0 0 0 0 0 0 0 0 4.10060236216416 0 0 0.00331481736263177 0.998970796346327 0.997973071099689 0.99955556151365 118 3) Uncertain significance No change no 1 +Amikacin rrs n.1211A>T rrs_n.1211A>T 1 non_coding_transcript_exon_variant 1473056 NA 0 0 0 2 21 2458 21957 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.999044499044499 0.998539784170517 0.999408435614546 0.0869565217391304 0.0107099660378758 0.280379335909411 NA NA NA 0 0 0.161097615219079 NA NA NA NA 1246 1832 False True 0.850749738463326 0.0966495499262663 3.48384411336892 0 0 0.00149963904330158 0.999044499044499 0.998539784170517 0.999408435614546 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 1 19 1110 7754 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.997555641322526 0.996185451564254 0.998527714753364 0.05 0.0012650894979498 0.248732762772027 NA NA NA 0 0 0.176466911806965 NA NA NA NA 520 981 False True 0 1 1 0 0 0 0 0.367662399241346 0.00884391399188652 2.31757537011368 0 0 0.00331779872508707 0.997555641322526 0.996185451564254 0.998527714753364 177 5) Not assoc w R UP from Uncertain to NotAwR yes 4 +Amikacin rrs n.1217T>A rrs_n.1217T>A 1 non_coding_transcript_exon_variant 1473062 NA 0 0 0 2 17 2458 21961 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.999226499226499 0.99876183824676 0.999549344777619 0.105263157894736 0.0130121643717774 0.331376664456765 NA NA NA 0 0 0.195064322969093 NA NA NA NA 1461 1832 False True 1.0511175991959 0.117710938762851 4.4327233739406 0 0 0.00149963904330158 0.999226499226499 0.99876183824676 0.999549344777619 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 1 15 1110 7758 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.998070243149363 0.996819153789367 0.998919540064859 0.0625 0.00158111172276588 0.302320738434531 NA NA NA 0 0 0.218019360910534 NA NA NA NA 723 981 False True 1 1 1 0 0 0 0 0.465945945945945 0.0110614822652538 3.03441935752574 0 0 0.00331779872508707 0.998070243149363 0.996819153789367 0.998919540064859 89 5) Not assoc w R New NotAwR yes 5 +Amikacin rrs n.1217T>G rrs_n.1217T>G 1 non_coding_transcript_exon_variant 1473062 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1323 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 592 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 1 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1220C>G rrs_n.1220C>G 1 non_coding_transcript_exon_variant 1473065 1 0 0 0 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1421 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 683 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 NA 3) Uncertain significance No change no 1 +Amikacin rrs n.1221A>G rrs_n.1221A>G 1 non_coding_transcript_exon_variant 1473066 1 0 0 0 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1555 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1111 7769 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 811 981 False False 0 0 0 0 0 0 0 0 0 10.6044836876068 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 108 3) Uncertain significance No change no 1 +Amikacin rrs n.1223A>G rrs_n.1223A>G 1 non_coding_transcript_exon_variant 1473068 NA 0 0 0 2 18 2458 21960 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.999180999180999 0.998705933279372 0.999514538264563 0.1 0.0123485271702948 0.316982714019082 NA NA NA 0 0 0.185301968137852 NA NA NA NA 1635 1832 False True 0.992676973148901 0.111634418469324 4.15021756681015 0 0 0.00149963904330158 0.999180999180999 0.998705933279372 0.999514538264563 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 1 16 1110 7757 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.997941592692654 0.996659422164099 0.998822998929686 0.0588235294117647 0.00148817439126663 0.28688939666722 NA NA NA 0 0 0.205907214207822 NA NA NA NA 890 981 False True 1 1 1 0 0 0 0 0.436768018018018 0.0104091785493508 2.81700277572341 0 0 0.00331779872508707 0.997941592692654 0.996659422164099 0.998822998929686 79 5) Not assoc w R New NotAwR yes 5 +Amikacin rrs n.1225G>A rrs_n.1225G>A 1 non_coding_transcript_exon_variant 1473070 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1422 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 684 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 6 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1229C>T rrs_n.1229C>T 1 non_coding_transcript_exon_variant 1473074 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1234G>A rrs_n.1234G>A 1 non_coding_transcript_exon_variant 1473079 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Amikacin rrs n.1235C>A rrs_n.1235C>A 1 non_coding_transcript_exon_variant 1473080 1 0 0 0 0 6 2460 21972 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1462 1832 False False 0 0 7.5904311186467 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 1111 7767 0 0 0.00331481736263177 0.999228097259745 0.998320655545558 0.999716674296114 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 724 981 False False 0 0 0 0 0 0 0 0 0 5.94541565066903 0 0 0.00331481736263177 0.999228097259745 0.998320655545558 0.999716674296114 3 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1235C>G rrs_n.1235C>G 1 non_coding_transcript_exon_variant 1473080 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1263 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 534 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1235C>T rrs_n.1235C>T 1 non_coding_transcript_exon_variant 1473080 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1247 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 521 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 14 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1236C>T rrs_n.1236C>T 1 non_coding_transcript_exon_variant 1473081 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1423 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 685 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 53 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1237G>A rrs_n.1237G>A 1 non_coding_transcript_exon_variant 1473082 1 0 0 0 0 8 2460 21970 0 0 0.00149842073847528 0.999635999635999 0.999282900840091 0.999842837798826 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1393 1832 False False 0 0 5.2353912865109 0 0 0.00149842073847528 0.999635999635999 0.999282900840091 0.999842837798826 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 1111 7767 0 0 0.00331481736263177 0.999228097259745 0.998320655545558 0.999716674296114 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 658 981 False False 0 0 0 0 0 0 0 0 0 5.94541565066903 0 0 0.00331481736263177 0.999228097259745 0.998320655545558 0.999716674296114 1 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1238G>T rrs_n.1238G>T 1 non_coding_transcript_exon_variant 1473083 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin rrs n.1239T>A rrs_n.1239T>A 1 non_coding_transcript_exon_variant 1473084 1 0 0 0 0 7 2460 21971 0 0 0.00149842073847528 0.999681499681499 0.999343878425726 0.999871937071415 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1530 1832 False False 0 0 6.20059597931892 0 0 0.00149842073847528 0.999681499681499 0.999343878425726 0.999871937071415 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 1111 7768 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 787 981 False False 0 0 0 0 0 0 0 0 0 7.63947436138835 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1239T>C rrs_n.1239T>C 1 non_coding_transcript_exon_variant 1473084 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 20 3) Uncertain significance No change no 1 +Amikacin rrs n.1243A>G rrs_n.1243A>G 1 non_coding_transcript_exon_variant 1473088 1 0 0 0 0 5 2460 21973 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1556 1832 False False 0 0 9.75275991328737 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 1111 7768 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 812 981 False False 0 0 0 0 0 0 0 0 0 7.63947436138835 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 84 3) Uncertain significance No change no 1 +Amikacin rrs n.1244A>C rrs_n.1244A>C 1 non_coding_transcript_exon_variant 1473089 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1324 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 593 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 1 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1244A>G rrs_n.1244A>G 1 non_coding_transcript_exon_variant 1473089 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.1244A>T rrs_n.1244A>T 1 non_coding_transcript_exon_variant 1473089 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1394 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 659 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 2 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1246G>A rrs_n.1246G>A 1 non_coding_transcript_exon_variant 1473091 1 0 0 0 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1463 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1111 7769 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 725 981 False False 0 0 0 0 0 0 0 0 0 10.6044836876068 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 5 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1248C>A rrs_n.1248C>A 1 non_coding_transcript_exon_variant 1473093 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1354 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 621 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 1 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1248C>G rrs_n.1248C>G 1 non_coding_transcript_exon_variant 1473093 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.1248C>T rrs_n.1248C>T 1 non_coding_transcript_exon_variant 1473093 1 0 0 0 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1337 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1111 7769 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 605 981 False False 0 0 0 0 0 0 0 0 0 10.6044836876068 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 65 3) Uncertain significance No change no 1 +Amikacin rrs n.1249T>A rrs_n.1249T>A 1 non_coding_transcript_exon_variant 1473094 1 0 0 0 0 9 2460 21969 0 0 0.00149842073847528 0.999590499590499 0.999222783640785 0.999812733785825 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1395 1832 False False 0 0 4.52743474605681 0 0 0.00149842073847528 0.999590499590499 0.999222783640785 0.999812733785825 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 7 1111 7766 0 0 0.00331481736263177 0.999099446803036 0.998145402056424 0.999637856686565 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 660 981 False False 0 0 0 0 0 0 0 0 0 4.85661817639599 0 0 0.00331481736263177 0.999099446803036 0.998145402056424 0.999637856686565 2 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.124T>C rrs_n.124T>C 1 non_coding_transcript_exon_variant 1471969 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1588 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 843 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 2 3) Uncertain significance No change no 1 +Amikacin rrs n.1253A>G rrs_n.1253A>G 1 non_coding_transcript_exon_variant 1473098 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.1254T>A rrs_n.1254T>A 1 non_coding_transcript_exon_variant 1473099 1 0 0 0 0 10 2460 21968 0 0 0.00149842073847528 0.999544999544999 0.999163397681526 0.999781788721324 0 0 0.30849710781876 NA NA NA 0 0 0.30849710781876 NA NA NA NA 1367 1832 False False 0 0 3.98680916993403 0 0 0.00149842073847528 0.999544999544999 0.999163397681526 0.999781788721324 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 8 1111 7765 0 0 0.00331481736263177 0.998970796346327 0.997973071099689 0.99955556151365 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 633 981 False False 0 0 0 0 0 0 0 0 0 4.10060236216416 0 0 0.00331481736263177 0.998970796346327 0.997973071099689 0.99955556151365 5 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1254T>G rrs_n.1254T>G 1 non_coding_transcript_exon_variant 1473099 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1289 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 557 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 4 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1255G>A rrs_n.1255G>A 1 non_coding_transcript_exon_variant 1473100 1 0 0 0 0 10 2460 21968 0 0 0.00149842073847528 0.999544999544999 0.999163397681526 0.999781788721324 0 0 0.30849710781876 NA NA NA 0 0 0.30849710781876 NA NA NA NA 1540 1832 False False 0 0 3.98680916993403 0 0 0.00149842073847528 0.999544999544999 0.999163397681526 0.999781788721324 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 10 1111 7763 0 0 0.00331481736263177 0.998713495432908 0.997635349133423 0.999382904111848 0 0 0.30849710781876 NA NA NA 0 0 0.30849710781876 NA NA NA NA 797 981 False False 0 0 0 0 0 0 0 0 0 3.12192331569373 0 0 0.00331481736263177 0.998713495432908 0.997635349133423 0.999382904111848 24 3) Uncertain significance No change no 1 +Amikacin rrs n.1256C>T rrs_n.1256C>T 1 non_coding_transcript_exon_variant 1473101 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1257C>G rrs_n.1257C>G 1 non_coding_transcript_exon_variant 1473102 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.1257C>T rrs_n.1257C>T 1 non_coding_transcript_exon_variant 1473102 1 1 0 1 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 346.534733964433 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 752 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 39 3) Uncertain significance No change no 1 +Amikacin rrs n.1259C>G rrs_n.1259C>G 1 non_coding_transcript_exon_variant 1473104 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.1259C>T rrs_n.1259C>T 1 non_coding_transcript_exon_variant 1473104 1 0 0 0 0 6 2460 21972 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1566 1832 False False 0 0 7.5904311186467 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 1111 7767 0 0 0.00331481736263177 0.999228097259745 0.998320655545558 0.999716674296114 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 821 981 False False 0 0 0 0 0 0 0 0 0 5.94541565066903 0 0 0.00331481736263177 0.999228097259745 0.998320655545558 0.999716674296114 30 3) Uncertain significance No change no 1 +Amikacin rrs n.125G>A rrs_n.125G>A 1 non_coding_transcript_exon_variant 1471970 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1636 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 891 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 15 3) Uncertain significance No change no 1 +Amikacin rrs n.-125G>T rrs_n.-125G>T 1 upstream_gene_variant 1471721 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.1260G>A rrs_n.1260G>A 1 non_coding_transcript_exon_variant 1473105 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1541 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 798 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 3 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1264T>C rrs_n.1264T>C 1 non_coding_transcript_exon_variant 1473109 1 1 0 1 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 346.503368577436 1 662.5 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 271.670627328402 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 1 3) Uncertain significance No change no 1 +Amikacin rrs n.1265T>G rrs_n.1265T>G 1 non_coding_transcript_exon_variant 1473110 1 0 0 0 0 8 2460 21970 0 0 0.00149842073847528 0.999635999635999 0.999282900840091 0.999842837798826 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1480 1832 False False 0 0 5.2353912865109 0 0 0.00149842073847528 0.999635999635999 0.999282900840091 0.999842837798826 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 8 1111 7765 0 0 0.00331481736263177 0.998970796346327 0.997973071099689 0.99955556151365 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 742 981 False False 0 0 0 0 0 0 0 0 0 4.10060236216416 0 0 0.00331481736263177 0.998970796346327 0.997973071099689 0.99955556151365 35 3) Uncertain significance No change no 1 +Amikacin rrs n.1266A>G rrs_n.1266A>G 1 non_coding_transcript_exon_variant 1473111 1 0 0 0 0 8 2460 21970 0 0 0.00149842073847528 0.999635999635999 0.999282900840091 0.999842837798826 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1424 1832 False False 0 0 5.2353912865109 0 0 0.00149842073847528 0.999635999635999 0.999282900840091 0.999842837798826 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 8 1111 7765 0 0 0.00331481736263177 0.998970796346327 0.997973071099689 0.99955556151365 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 686 981 False False 0 0 0 0 0 0 0 0 0 4.10060236216416 0 0 0.00331481736263177 0.998970796346327 0.997973071099689 0.99955556151365 39 3) Uncertain significance No change no 1 +Amikacin rrs n.126A>C rrs_n.126A>C 1 non_coding_transcript_exon_variant 1471971 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin rrs n.1270G>C rrs_n.1270G>C 1 non_coding_transcript_exon_variant 1473115 1 0 0 0 0 9 2460 21969 0 0 0.00149842073847528 0.999590499590499 0.999222783640785 0.999812733785825 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1505 1832 False False 0 0 4.52743474605681 0 0 0.00149842073847528 0.999590499590499 0.999222783640785 0.999812733785825 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 7 1111 7766 0 0 0.00331481736263177 0.999099446803036 0.998145402056424 0.999637856686565 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 766 981 False False 0 0 0 0 0 0 0 0 0 4.85661817639599 0 0 0.00331481736263177 0.999099446803036 0.998145402056424 0.999637856686565 2 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1270G>T rrs_n.1270G>T 1 non_coding_transcript_exon_variant 1473115 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1368 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 634 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 11 3) Uncertain significance No change no 1 +Amikacin rrs n.1275C>T rrs_n.1275C>T 1 non_coding_transcript_exon_variant 1473120 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1601 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 858 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 4 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1276T>C rrs_n.1276T>C 1 non_coding_transcript_exon_variant 1473121 NA 0 0 0 0 13 2460 21965 0 0 0.00149842073847528 0.999408499408499 0.998988728376916 0.999685014453566 0 0 0.24705263800047 NA NA NA 0 0 0.24705263800047 NA NA NA NA 1355 1832 False True 0 0 2.93170145225031 0 0 0.00149842073847528 0.999408499408499 0.998988728376916 0.999685014453566 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 12 1111 7761 0 0 0.00331481736263177 0.99845619451949 0.997304837007313 0.999202046759043 0 0 0.264648469397051 NA NA NA 0 0 0.264648469397051 NA NA NA NA 622 981 False True 0 1 1 0 0 0 0 0 0 2.51816344117143 0 0 0.00331481736263177 0.99845619451949 0.997304837007313 0.999202046759043 87 5) Not assoc w R UP from Uncertain to NotAwR yes 4 +Amikacin rrs n.1276T>G rrs_n.1276T>G 1 non_coding_transcript_exon_variant 1473121 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1396 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.1277T>A rrs_n.1277T>A 1 non_coding_transcript_exon_variant 1473122 NA 0 0 0 0 8 2460 21970 0 0 0.00149842073847528 0.999635999635999 0.999282900840091 0.999842837798826 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1290 1832 False True 0 0 5.2353912865109 0 0 0.00149842073847528 0.999635999635999 0.999282900840091 0.999842837798826 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 7 1111 7766 0 0 0.00331481736263177 0.999099446803036 0.998145402056424 0.999637856686565 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 558 981 False True 1 0 1 0 0 0 0 0 0 4.85661817639599 0 0 0.00331481736263177 0.999099446803036 0.998145402056424 0.999637856686565 8 5) Not assoc w R New NotAwR yes 5 +Amikacin rrs n.1278A>C rrs_n.1278A>C 1 non_coding_transcript_exon_variant 1473123 1 0 0 0 0 5 2460 21973 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1611 1832 False False 0 0 9.75275991328737 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1111 7769 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 868 981 False False 0 0 0 0 0 0 0 0 0 10.6044836876068 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1278A>G rrs_n.1278A>G 1 non_coding_transcript_exon_variant 1473123 1 4 0 4 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 13.5427650126618 1 662.5 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 3) Uncertain significance No change no 1 +Amikacin rrs n.1278A>T rrs_n.1278A>T 1 non_coding_transcript_exon_variant 1473123 1 0 0 0 0 5 2460 21973 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1439 1832 False False 0 0 9.75275991328737 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 1111 7768 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 702 981 False False 0 0 0 0 0 0 0 0 0 7.63947436138835 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 62 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1278delAinsTC rrs_n.1278delAinsTC 1 non_coding_transcript_exon_variant 1473123 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1506 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 767 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1279A>T rrs_n.1279A>T 1 non_coding_transcript_exon_variant 1473124 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1542 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 799 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 2 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1282G>A rrs_n.1282G>A 1 non_coding_transcript_exon_variant 1473127 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1464 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 726 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 3 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1282G>T rrs_n.1282G>T 1 non_coding_transcript_exon_variant 1473127 1 0 0 0 0 5 2460 21973 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1369 1832 False False 0 0 9.75275991328737 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1111 7769 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 635 981 False False 0 0 0 0 0 0 0 0 0 10.6044836876068 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1283C>T rrs_n.1283C>T 1 non_coding_transcript_exon_variant 1473128 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin rrs n.1284C>T rrs_n.1284C>T 1 non_coding_transcript_exon_variant 1473129 1 0 0 0 0 7 2460 21971 0 0 0.00149842073847528 0.999681499681499 0.999343878425726 0.999871937071415 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1370 1832 False False 0 0 6.20059597931892 0 0 0.00149842073847528 0.999681499681499 0.999343878425726 0.999871937071415 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 1111 7767 0 0 0.00331481736263177 0.999228097259745 0.998320655545558 0.999716674296114 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 636 981 False False 0 0 0 0 0 0 0 0 0 5.94541565066903 0 0 0.00331481736263177 0.999228097259745 0.998320655545558 0.999716674296114 2 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1285G>A rrs_n.1285G>A 1 non_coding_transcript_exon_variant 1473130 1 4 0 4 0 6 2460 21972 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 0 0 0.4592581264399 0 0 0.602364635616474 0 0 0.4592581264399 0 0 13.5415294433897 1 165 1832 False False 0 0 7.5904311186467 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 5 1111 7768 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 16.930217557563 1 267 981 False False 0 0 0 0 0 0 0 0 0 7.63947436138835 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 40 3) Uncertain significance No change no 1 +Amikacin rrs n.1286G>T rrs_n.1286G>T 1 non_coding_transcript_exon_variant 1473131 1 0 0 0 0 6 2460 21972 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1448 1832 False False 0 0 7.5904311186467 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 1111 7768 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 710 981 False False 0 0 0 0 0 0 0 0 0 7.63947436138835 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 2 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1289T>C rrs_n.1289T>C 1 non_coding_transcript_exon_variant 1473134 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.1300C>T rrs_n.1300C>T 1 non_coding_transcript_exon_variant 1473145 1 2 0 2 0 14 2460 21964 0 0 0.00149842073847528 0.999362999362999 0.998931451908832 0.999651703457902 0 0 0.231635761650116 0 0 0.841886116991581 0 0 0.231635761650116 0 0 47.527455848538 1 662.5 1832 False False 0 0 2.69356616691972 0 0 0.00149842073847528 0.999362999362999 0.998931451908832 0.999651703457902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 13 1111 7760 0 0 0.00331481736263177 0.998327544062781 0.997141747487123 0.999109196577396 0 0 0.24705263800047 0 0 0.975 0 0 0.24705263800047 0 0 271.287751677852 1 267 981 False False 0 0 0 0 0 0 0 0 0 2.29557234301212 0 0 0.00331481736263177 0.998327544062781 0.997141747487123 0.999109196577396 139 3) Uncertain significance No change no 1 +Amikacin rrs n.1302G>A rrs_n.1302G>A 1 non_coding_transcript_exon_variant 1473147 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 10 3) Uncertain significance No change no 1 +Amikacin rrs n.1302G>C rrs_n.1302G>C 1 non_coding_transcript_exon_variant 1473147 NA 0 0 0 1 10 2459 21968 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999544999544999 0.999163397681526 0.999781788721324 0.0909090909090909 0.00229897221381426 0.412779916988382 NA NA NA 0 0 0.30849710781876 NA NA NA NA 1278 1832 False True 0.893371289141927 0.020577382163102 6.28488216182158 0 0 0.00149902964335061 0.999544999544999 0.999163397681526 0.999781788721324 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 8 1111 7765 0 0 0.00331481736263177 0.998970796346327 0.997973071099689 0.99955556151365 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 548 981 False True 1 1 1 0 0 0 0 0 0 4.10060236216416 0 0 0.00331481736263177 0.998970796346327 0.997973071099689 0.99955556151365 5 5) Not assoc w R New NotAwR yes 5 +Amikacin rrs n.1302G>T rrs_n.1302G>T 1 non_coding_transcript_exon_variant 1473147 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1377 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 642 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 8 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1303G>A rrs_n.1303G>A 1 non_coding_transcript_exon_variant 1473148 0 0 0 0 1 11 2459 21967 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999499499499499 0.999104643231992 0.999750126319878 0.0833333333333333 0.00210759323186022 0.384796165150944 NA NA NA 0 0 0.284914152918154 NA NA NA NA 1248 1832 False False 0.812118747458316 0.0188599260109937 5.5927738644815 0 0 0.00149902964335061 0.999499499499499 0.999104643231992 0.999750126319878 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 9 1111 7764 0 0 0.00331481736263177 0.998842145889618 0.997803175208698 0.999470423012169 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 522 981 False False 0 0 0 0 0 0 0 0 0 3.54586915871032 0 0 0.00331481736263177 0.998842145889618 0.997803175208698 0.999470423012169 16 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1305T>G rrs_n.1305T>G 1 non_coding_transcript_exon_variant 1473150 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1409 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 672 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 4 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.-130T>C rrs_n.-130T>C 1 upstream_gene_variant 1471716 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1316A>C rrs_n.1316A>C 1 non_coding_transcript_exon_variant 1473161 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1325 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 594 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 6 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1317C>T rrs_n.1317C>T 1 non_coding_transcript_exon_variant 1473162 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.1318C>T rrs_n.1318C>T 1 non_coding_transcript_exon_variant 1473163 1 0 0 0 0 11 2460 21967 0 0 0.00149842073847528 0.999499499499499 0.999104643231992 0.999750126319878 0 0 0.284914152918154 NA NA NA 0 0 0.284914152918154 NA NA NA NA 1410 1832 False False 0 0 3.56038548490505 0 0 0.00149842073847528 0.999499499499499 0.999104643231992 0.999750126319878 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 9 1111 7764 0 0 0.00331481736263177 0.998842145889618 0.997803175208698 0.999470423012169 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 673 981 False False 0 0 0 0 0 0 0 0 0 3.54586915871032 0 0 0.00331481736263177 0.998842145889618 0.997803175208698 0.999470423012169 21 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1319C>A rrs_n.1319C>A 1 non_coding_transcript_exon_variant 1473164 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1637 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 892 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 10 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1319C>G rrs_n.1319C>G 1 non_coding_transcript_exon_variant 1473164 NA 0 0 0 0 10 2460 21968 0 0 0.00149842073847528 0.999544999544999 0.999163397681526 0.999781788721324 0 0 0.30849710781876 NA NA NA 0 0 0.30849710781876 NA NA NA NA 1411 1832 False True 0 0 3.98680916993403 0 0 0.00149842073847528 0.999544999544999 0.999163397681526 0.999781788721324 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 8 1111 7765 0 0 0.00331481736263177 0.998970796346327 0.997973071099689 0.99955556151365 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 674 981 False True 1 1 1 0 0 0 0 0 0 4.10060236216416 0 0 0.00331481736263177 0.998970796346327 0.997973071099689 0.99955556151365 5 5) Not assoc w R New NotAwR yes 5 +Amikacin rrs n.1320C>T rrs_n.1320C>T 1 non_coding_transcript_exon_variant 1473165 0 0 0 0 1 1 2459 21977 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.9999544999545 0.999746516336938 0.999998848039248 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1449 1832 False False 8.93737291581943 0.113810496005924 697.318539256027 0 0 0.00149902964335061 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 711 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance No change no 1 +Amikacin rrs n.1321G>A rrs_n.1321G>A 1 non_coding_transcript_exon_variant 1473166 1 0 0 0 0 13 2460 21965 0 0 0.00149842073847528 0.999408499408499 0.998988728376916 0.999685014453566 0 0 0.24705263800047 NA NA NA 0 0 0.24705263800047 NA NA NA NA 1638 1832 False False 0 0 2.93170145225031 0 0 0.00149842073847528 0.999408499408499 0.998988728376916 0.999685014453566 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 13 1111 7760 0 0 0.00331481736263177 0.998327544062781 0.997141747487123 0.999109196577396 0 0 0.24705263800047 NA NA NA 0 0 0.24705263800047 NA NA NA NA 893 981 False False 0 0 0 0 0 0 0 0 0 2.29557234301212 0 0 0.00331481736263177 0.998327544062781 0.997141747487123 0.999109196577396 142 3) Uncertain significance No change no 1 +Amikacin rrs n.1322T>G rrs_n.1322T>G 1 non_coding_transcript_exon_variant 1473167 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1323G>T rrs_n.1323G>T 1 non_coding_transcript_exon_variant 1473168 1 5 0 5 0 5 2460 21973 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 9.75275991328737 1 662.5 1832 False False 0 0 9.75275991328737 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance No change no 1 +Amikacin rrs n.1325A>C rrs_n.1325A>C 1 non_coding_transcript_exon_variant 1473170 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin rrs n.1327T>C rrs_n.1327T>C 1 non_coding_transcript_exon_variant 1473172 NA 0 0 0 0 9 2460 21969 0 0 0.00149842073847528 0.999590499590499 0.999222783640785 0.999812733785825 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1338 1832 False True 0 0 4.52743474605681 0 0 0.00149842073847528 0.999590499590499 0.999222783640785 0.999812733785825 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 7 1111 7766 0 0 0.00331481736263177 0.999099446803036 0.998145402056424 0.999637856686565 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 606 981 False True 1 1 1 0 0 0 0 0 0 4.85661817639599 0 0 0.00331481736263177 0.999099446803036 0.998145402056424 0.999637856686565 16 5) Not assoc w R New NotAwR yes 5 +Amikacin rrs n.1327T>G rrs_n.1327T>G 1 non_coding_transcript_exon_variant 1473172 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 46 3) Uncertain significance No change no 1 +Amikacin rrs n.1328C>T rrs_n.1328C>T 1 non_coding_transcript_exon_variant 1473173 1 1 0 1 0 12 2460 21966 0 0 0.00149842073847528 0.999453999453999 0.999046441372309 0.999717842739244 0 0 0.264648469397051 0 0 0.975 0 0 0.264648469397051 0 0 346.37790672034 1 662.5 1832 False True 0 0 3.21614145803178 0 0 0.00149842073847528 0.999453999453999 0.999046441372309 0.999717842739244 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 9 1111 7764 0 0 0.00331481736263177 0.998842145889618 0.997803175208698 0.999470423012169 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 753 981 False True 1 1 1 0 0 0 0 0 0 3.54586915871032 0 0 0.00331481736263177 0.998842145889618 0.997803175208698 0.999470423012169 60 5) Not assoc w R UP from Uncertain to NotAwR yes 4 +Amikacin rrs n.1332G>A rrs_n.1332G>A 1 non_coding_transcript_exon_variant 1473177 NA 0 0 0 1 14 2459 21964 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999362999362999 0.998931451908832 0.999651703457902 0.0666666666666666 0.0016864302413527 0.319484566578303 NA NA NA 0 0 0.231635761650116 NA NA NA NA 1303 1832 False True 0.638006158136292 0.0150856928331773 4.19687003176341 0 0 0.00149902964335061 0.999362999362999 0.998931451908832 0.999651703457902 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 12 1111 7761 0 0 0.00331481736263177 0.99845619451949 0.997304837007313 0.999202046759043 0 0 0.264648469397051 NA NA NA 0 0 0.264648469397051 NA NA NA NA 571 981 False True 1 1 1 0 0 0 0 0 0 2.51816344117143 0 0 0.00331481736263177 0.99845619451949 0.997304837007313 0.999202046759043 151 5) Not assoc w R New NotAwR yes 5 +Amikacin rrs n.1334C>T rrs_n.1334C>T 1 non_coding_transcript_exon_variant 1473179 1 0 0 0 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1304 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1111 7769 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 572 981 False False 0 0 0 0 0 0 0 0 0 10.6044836876068 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 5 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.133C>T rrs_n.133C>T 1 non_coding_transcript_exon_variant 1471978 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1264 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 535 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1341A>G rrs_n.1341A>G 1 non_coding_transcript_exon_variant 1473186 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1492 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.1346C>T rrs_n.1346C>T 1 non_coding_transcript_exon_variant 1473191 1 1 0 1 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 346.519051274799 1 662.5 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 573 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 29 3) Uncertain significance No change no 1 +Amikacin rrs n.1347A>G rrs_n.1347A>G 1 non_coding_transcript_exon_variant 1473192 NA 0 0 0 1 15 2459 21963 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999317499317499 0.998874568358369 0.999617960830416 0.0625 0.00158111172276588 0.302320738434531 NA NA NA 0 0 0.218019360910534 NA NA NA NA 1412 1832 False True 0.595445302968686 0.0141416389361868 3.87379351595292 0 0 0.00149902964335061 0.999317499317499 0.998874568358369 0.999617960830416 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 12 1111 7761 0 0 0.00331481736263177 0.99845619451949 0.997304837007313 0.999202046759043 0 0 0.264648469397051 NA NA NA 0 0 0.264648469397051 NA NA NA NA 675 981 False True 0 1 1 0 0 0 0 0 0 2.51816344117143 0 0 0.00331481736263177 0.99845619451949 0.997304837007313 0.999202046759043 156 5) Not assoc w R New NotAwR yes 5 +Amikacin rrs n.1348G>A rrs_n.1348G>A 1 non_coding_transcript_exon_variant 1473193 1 4 0 4 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 13.5427650126618 1 662.5 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.134T>C rrs_n.134T>C 1 non_coding_transcript_exon_variant 1471979 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1602 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 859 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 3 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1356_1357delACinsT rrs_n.1356_1357delACinsT 1 non_coding_transcript_exon_variant 1473201 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1356 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 623 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 32 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1356_1360delACGCTinsTGCC rrs_n.1356_1360delACGCTinsTGCC 1 non_coding_transcript_exon_variant 1473201 0 0 0 0 1 11 2459 21967 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999499499499499 0.999104643231992 0.999750126319878 0.0833333333333333 0.00210759323186022 0.384796165150944 NA NA NA 0 0 0.284914152918154 NA NA NA NA 1465 1832 False False 0.812118747458316 0.0188599260109937 5.5927738644815 0 0 0.00149902964335061 0.999499499499499 0.999104643231992 0.999750126319878 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 9 1111 7764 0 0 0.00331481736263177 0.998842145889618 0.997803175208698 0.999470423012169 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 727 981 False False 0 0 0 0 0 0 0 0 0 3.54586915871032 0 0 0.00331481736263177 0.998842145889618 0.997803175208698 0.999470423012169 21 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1356A>T rrs_n.1356A>T 1 non_coding_transcript_exon_variant 1473201 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1425 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 687 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1356delA rrs_n.1356delA 1 non_coding_transcript_exon_variant 1473199 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1426 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 688 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 134 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1357C>T rrs_n.1357C>T 1 non_coding_transcript_exon_variant 1473202 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1519 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 779 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 6 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1359C>T rrs_n.1359C>T 1 non_coding_transcript_exon_variant 1473204 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.-135G>T rrs_n.-135G>T 1 upstream_gene_variant 1471711 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1360T>C rrs_n.1360T>C 1 non_coding_transcript_exon_variant 1473205 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1249 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 523 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 154 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1361G>A rrs_n.1361G>A 1 non_coding_transcript_exon_variant 1473206 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1326 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 595 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 30 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1361G>C rrs_n.1361G>C 1 non_coding_transcript_exon_variant 1473206 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1367A>G rrs_n.1367A>G 1 non_coding_transcript_exon_variant 1473212 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.136C>T rrs_n.136C>T 1 non_coding_transcript_exon_variant 1471981 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1379G>A rrs_n.1379G>A 1 non_coding_transcript_exon_variant 1473224 1 11 0 11 0 11 2460 21967 0 0 0.00149842073847528 0.999499499499499 0.999104643231992 0.999750126319878 0 0 0.284914152918154 0 0 0.284914152918154 0 0 0.284914152918154 0 0 3.56038548490505 0.616667685925898 131.5 1832 False False 0 0 3.56038548490505 0 0 0.00149842073847528 0.999499499499499 0.999104643231992 0.999750126319878 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 1111 7767 0 0 0.00331481736263177 0.999228097259745 0.998320655545558 0.999716674296114 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 5.94541565066903 1 75.5 981 False False 0 0 0 0 0 0 0 0 0 5.94541565066903 0 0 0.00331481736263177 0.999228097259745 0.998320655545558 0.999716674296114 2 3) Uncertain significance No change no 1 +Amikacin rrs n.1381C>T rrs_n.1381C>T 1 non_coding_transcript_exon_variant 1473226 1 0 0 0 0 6 2460 21972 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1567 1832 False False 0 0 7.5904311186467 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 1111 7768 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 822 981 False False 0 0 0 0 0 0 0 0 0 7.63947436138835 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 43 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.138C>T rrs_n.138C>T 1 non_coding_transcript_exon_variant 1471983 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1639 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 894 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.13A>G rrs_n.13A>G 1 non_coding_transcript_exon_variant 1471858 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1401A>G rrs_n.1401A>G 1 non_coding_transcript_exon_variant 1473246 1 1648 1526 122 1682 147 778 21831 0.683739837398374 0.66495001902233 0.702091247248079 0.993311493311493 0.992143274110037 0.994346197064629 0.91962821213778 0.906210953427128 0.931680295542164 0.925970873786407 0.912252563561156 0.938147334070796 0.912133891213389 0.897535651195651 0.925266256167765 350.985144759576 285.584806978159 429.727166466262 0 1 1832 True False 321.072189287025 266.840390879463 390.202686133698 0.662326388888888 0.642601931294181 0.681637228215652 0.993311493311493 0.992143274110037 0.994346197064629 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 749 689 60 776 71 335 7702 0.698469846984698 0.670534231280736 0.725350081228177 0.990865817573652 0.988492244114582 0.992859431674623 0.916174734356552 0.895439765789059 0.933953454933066 0.919893190921228 0.898087194290624 0.938315901388175 0.906578947368421 0.883622489897832 0.926316682269796 264.013830845771 196.352810137894 362.868621075627 0 1 981 True False 0 0 0 0 0 0 0 251.282404877023 191.844045377945 329.644388326971 0.6728515625 0.643161110678453 0.701544478966046 0.990865817573652 0.988492244114582 0.992859431674623 878 Assoc w R Assoc w R Marker of R 1) Assoc w R No change yes 1 +Amikacin rrs n.1402C>A rrs_n.1402C>A 1 non_coding_transcript_exon_variant 1473247 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1339 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 607 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 21 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1402C>T rrs_n.1402C>T 1 non_coding_transcript_exon_variant 1473247 1 18 6 12 9 14 2451 21964 0.00365853658536585 0.00167423871507945 0.00693363251119005 0.999362999362999 0.998931451908832 0.999651703457902 0.391304347826087 0.197076423969014 0.61458104261115 0.333333333333333 0.133427402506123 0.590074761827925 0.3 0.118931590405727 0.542789182276289 4.48062015503876 1.3783936565824 12.9135462563086 0.00657175202621134 15 1832 False False 5.76079734219269 2.19688033280612 14.3050656325123 0.00244200244200244 0.000896682666950257 0.00530757847544534 0.999362999362999 0.998931451908832 0.999651703457902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 4 7 5 8 1106 7765 0.0045004500450045 0.00146284970071471 0.0104710615528963 0.998970796346327 0.997973071099689 0.99955556151365 0.384615384615384 0.13857933889016 0.684222397085936 0.363636363636363 0.109263443819098 0.692095284988322 0.333333333333333 0.0992460911495833 0.651124493581186 4.01188323430638 0.859621717145008 15.8074249290028 0.038840575180857 12 981 False False 0 0 0 0 0 0 0 4.3879972875226 1.12704953670495 15.2410389810325 0.0036036036036036 0.000982706767419398 0.00920074319187502 0.998970796346327 0.997973071099689 0.99955556151365 11 Assoc w RI Marker of R WHO-endorsed gDST assay 2) Assoc w R - Interim No change yes WHO-end. gDST 1 +Amikacin rrs n.1403G>A rrs_n.1403G>A 1 non_coding_transcript_exon_variant 1473248 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1568 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 823 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 8 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1404T>C rrs_n.1404T>C 1 non_coding_transcript_exon_variant 1473249 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1481 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 743 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 8 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1407T>C rrs_n.1407T>C 1 non_coding_transcript_exon_variant 1473252 NA 0 0 0 0 8 2460 21970 0 0 0.00149842073847528 0.999635999635999 0.999282900840091 0.999842837798826 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1603 1832 False True 0 0 5.2353912865109 0 0 0.00149842073847528 0.999635999635999 0.999282900840091 0.999842837798826 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 7 1111 7766 0 0 0.00331481736263177 0.999099446803036 0.998145402056424 0.999637856686565 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 860 981 False True 0 1 1 0 0 0 0 0 0 4.85661817639599 0 0 0.00331481736263177 0.999099446803036 0.998145402056424 0.999637856686565 75 5) Not assoc w R New NotAwR yes 5 +Amikacin rrs n.1409A>G rrs_n.1409A>G 1 non_coding_transcript_exon_variant 1473254 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin rrs n.140T>C rrs_n.140T>C 1 non_coding_transcript_exon_variant 1471985 1 0 0 0 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1482 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1111 7769 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 744 981 False False 0 0 0 0 0 0 0 0 0 10.6044836876068 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 4 3) Uncertain significance No change no 1 +Amikacin rrs n.140T>G rrs_n.140T>G 1 non_coding_transcript_exon_variant 1471985 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 37.2625869115887 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 NA 3) Uncertain significance No change no 1 +Amikacin rrs n.1410A>G rrs_n.1410A>G 1 non_coding_transcript_exon_variant 1473255 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1582 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 839 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 5 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1413T>C rrs_n.1413T>C 1 non_coding_transcript_exon_variant 1473258 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1265 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 536 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1414C>T rrs_n.1414C>T 1 non_coding_transcript_exon_variant 1473259 0 0 0 0 0 6 2460 21972 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1450 1832 False True 0 0 7.5904311186467 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 4 1111 7769 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 712 981 False True 0 1 1 0 0 0 0 0 0 10.6044836876068 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 82 5) Not assoc w R UP from Uncertain to NotAwR yes 4 +Amikacin rrs n.1415G>T rrs_n.1415G>T 1 non_coding_transcript_exon_variant 1473260 1 1 0 1 1 2 2459 21976 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999908999909 0.999671315452743 0.999988979276808 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 346.674895666859 1 165 1832 False False 4.46848312322082 0.0757100934104112 86.0774363890598 0 0 0.00149902964335061 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 1110 7772 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.99987134954329 0.999283416286792 0.999996742857744 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 271.949173528644 1 75.5 981 False False 0 0 0 0 0 0 0 7.0018018018018 0.0891187877143753 547.10724479397 0 0 0.00331779872508707 0.99987134954329 0.999283416286792 0.999996742857744 5 3) Uncertain significance No change no 1 +Amikacin rrs n.1416G>A rrs_n.1416G>A 1 non_coding_transcript_exon_variant 1473261 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.-141A>G rrs_n.-141A>G 1 upstream_gene_variant 1471705 1 5 1 4 1 4 2459 21974 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999817999817999 0.999534073414941 0.999950408920832 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 2.23403822692151 0.045345258756558 22.5860023464291 0.411708397828794 102 1832 False False 2.23403822692151 0.045345258756558 22.5860023464291 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Amikacin rrs n.141C>T rrs_n.141C>T 1 non_coding_transcript_exon_variant 1471986 1 2 0 2 0 7 2460 21971 0 0 0.00149842073847528 0.999681499681499 0.999343878425726 0.999871937071415 0 0 0.409616397225003 0 0 0.841886116991581 0 0 0.409616397225003 0 0 47.5425447660943 1 662.5 1832 False False 0 0 6.20059597931892 0 0 0.00149842073847528 0.999681499681499 0.999343878425726 0.999871937071415 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 6 1111 7767 0 0 0.00331481736263177 0.999228097259745 0.998320655545558 0.999716674296114 0 0 0.4592581264399 0 0 0.975 0 0 0.4592581264399 0 0 271.531400351408 1 267 981 False False 0 0 0 0 0 0 0 0 0 5.94541565066903 0 0 0.00331481736263177 0.999228097259745 0.998320655545558 0.999716674296114 9 3) Uncertain significance No change no 1 +Amikacin rrs n.1425G>A rrs_n.1425G>A 1 non_coding_transcript_exon_variant 1473270 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.-142C>T rrs_n.-142C>T 1 upstream_gene_variant 1471704 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.142G>A rrs_n.142G>A 1 non_coding_transcript_exon_variant 1471987 1 9 0 9 0 9 2460 21969 0 0 0.00149842073847528 0.999590499590499 0.999222783640785 0.999812733785825 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.336267116879942 0 0 4.52743474605681 0.612226157450036 119.5 1832 False False 0 0 4.52743474605681 0 0 0.00149842073847528 0.999590499590499 0.999222783640785 0.999812733785825 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 1111 7769 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 10.6044836876068 1 267 981 False False 0 0 0 0 0 0 0 0 0 10.6044836876068 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 4 3) Uncertain significance No change no 1 +Amikacin rrs n.1431A>G rrs_n.1431A>G 1 non_coding_transcript_exon_variant 1473276 1 0 0 0 0 6 2460 21972 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1543 1832 False False 0 0 7.5904311186467 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 1111 7768 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 800 981 False False 0 0 0 0 0 0 0 0 0 7.63947436138835 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 29 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1432G>A rrs_n.1432G>A 1 non_coding_transcript_exon_variant 1473277 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 34 3) Uncertain significance No change no 1 +Amikacin rrs n.1436C>A rrs_n.1436C>A 1 non_coding_transcript_exon_variant 1473281 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1378 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1437C>G rrs_n.1437C>G 1 non_coding_transcript_exon_variant 1473282 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1235 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1438T>C rrs_n.1438T>C 1 non_coding_transcript_exon_variant 1473283 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1357 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 624 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 3 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1443_1446delCTCGinsTTTTA rrs_n.1443_1446delCTCGinsTTTTA 1 non_coding_transcript_exon_variant 1473288 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1520 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1443C>G rrs_n.1443C>G 1 non_coding_transcript_exon_variant 1473288 1 27 0 27 1 28 2459 21950 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.998725998725998 0.998159235769423 0.999153273664351 0.0344827586206896 0.000872646883579922 0.177644295488722 0 0 0.127702867615432 0 0 0.123436118500263 0 0 1.3078677135844 0.105164092631348 59 1832 False False 0.318799744379248 0.0077964281908789 1.93007678271173 0 0 0.00149902964335061 0.998725998725998 0.998159235769423 0.999153273664351 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 18 0 18 1 19 1110 7754 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.997555641322526 0.996185451564254 0.998527714753364 0.05 0.0012650894979498 0.248732762772027 0 0 0.185301968137852 0 0 0.176466911806965 0 0 1.59164689358091 0.154627988222584 32 981 False False 0 0 0 0 0 0 0 0.367662399241346 0.00884391399188652 2.31757537011368 0 0 0.00331779872508707 0.997555641322526 0.996185451564254 0.998527714753364 61 3) Uncertain significance No change no 1 +Amikacin rrs n.1443C>T rrs_n.1443C>T 1 non_coding_transcript_exon_variant 1473288 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1544 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 801 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 2 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1444_1445delTCinsCTCGT rrs_n.1444_1445delTCinsCTCGT 1 non_coding_transcript_exon_variant 1473289 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1279 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 549 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1444_1445delTCinsCTTGT rrs_n.1444_1445delTCinsCTTGT 1 non_coding_transcript_exon_variant 1473289 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1545 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 802 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 1 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1445_1446delCGinsTGT rrs_n.1445_1446delCGinsTGT 1 non_coding_transcript_exon_variant 1473290 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1493 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 754 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 2 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1445C>A rrs_n.1445C>A 1 non_coding_transcript_exon_variant 1473290 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1445C>T rrs_n.1445C>T 1 non_coding_transcript_exon_variant 1473290 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1291 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 559 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 10 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1446G>T rrs_n.1446G>T 1 non_coding_transcript_exon_variant 1473291 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1250 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 524 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 3 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1449A>G rrs_n.1449A>G 1 non_coding_transcript_exon_variant 1473294 1 4 0 4 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 13.5427650126618 1 662.5 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 12 3) Uncertain significance No change no 1 +Amikacin rrs n.1451G>C rrs_n.1451G>C 1 non_coding_transcript_exon_variant 1473296 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1569 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1452G>T rrs_n.1452G>T 1 non_coding_transcript_exon_variant 1473297 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1483 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1454G>C rrs_n.1454G>C 1 non_coding_transcript_exon_variant 1473299 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.1456T>C rrs_n.1456T>C 1 non_coding_transcript_exon_variant 1473301 1 0 0 0 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1316 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 585 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 22 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1460G>A rrs_n.1460G>A 1 non_coding_transcript_exon_variant 1473305 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 3 3) Uncertain significance No change no 1 +Amikacin rrs n.1461A>G rrs_n.1461A>G 1 non_coding_transcript_exon_variant 1473306 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1465T>G rrs_n.1465T>G 1 non_coding_transcript_exon_variant 1473310 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.1468G>A rrs_n.1468G>A 1 non_coding_transcript_exon_variant 1473313 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1470T>C rrs_n.1470T>C 1 non_coding_transcript_exon_variant 1473315 1 0 0 0 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1624 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 879 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 14 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1471C>A rrs_n.1471C>A 1 non_coding_transcript_exon_variant 1473316 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1612 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1471C>T rrs_n.1471C>T 1 non_coding_transcript_exon_variant 1473316 1 0 0 0 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1546 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1111 7769 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 803 981 False False 0 0 0 0 0 0 0 0 0 10.6044836876068 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 59 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1472G>A rrs_n.1472G>A 1 non_coding_transcript_exon_variant 1473317 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1531 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1473G>A rrs_n.1473G>A 1 non_coding_transcript_exon_variant 1473318 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1358 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1474C>T rrs_n.1474C>T 1 non_coding_transcript_exon_variant 1473319 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1280 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 12 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.-147G>T rrs_n.-147G>T 1 upstream_gene_variant 1471699 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1482A>G rrs_n.1482A>G 1 non_coding_transcript_exon_variant 1473327 1 1 0 1 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 346.534733964433 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance No change no 1 +Amikacin rrs n.1483C>T rrs_n.1483C>T 1 non_coding_transcript_exon_variant 1473328 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1251 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1484G>A rrs_n.1484G>A 1 non_coding_transcript_exon_variant 1473329 1 2 1 1 1 1 2459 21977 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.9999544999545 0.999746516336938 0.999998848039248 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 8.93737291581943 0.113810496005924 697.318539256027 0.191196488852352 72.5 1832 False False 8.93737291581943 0.113810496005924 697.318539256027 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.1484G>T rrs_n.1484G>T 1 non_coding_transcript_exon_variant 1473329 1 17 12 5 17 5 2443 21973 0.00691056910569105 0.00403066294102424 0.0110415047085623 0.999772499772499 0.99946917089695 0.999926127301238 0.772727272727272 0.546296376337878 0.921793739648107 0.705882352941176 0.440417281245662 0.89686448562968 0.705882352941176 0.440417281245662 0.89686448562968 21.5862464183381 7.06966217422045 78.4028561413389 3.94268786110791e-09 4 1832 True False 30.5805157593123 10.8156285849828 106.330175676089 0.00488798370672097 0.00252816609223198 0.00852274127152663 0.999772499772499 0.99946917089695 0.999926127301238 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 12 10 2 11 2 1100 7771 0.0099009900990099 0.00495260756732035 0.0176464076734019 0.999742699086581 0.999070852951501 0.999968838146642 0.846153846153846 0.545528944323442 0.980793328017471 0.833333333333333 0.515862251314033 0.979137474539907 0.833333333333333 0.515862251314033 0.979137474539907 35.3227272727272 7.50855049940947 331.536799386397 4.65493135002753e-08 3 981 True False 0 0 0 0 0 0 0 38.855 8.45825716991171 360.774775591484 0.009009009009009 0.00432838195184951 0.0165052986818499 0.999742699086581 0.999070852951501 0.999968838146642 23 Assoc w R Assoc w RI Marker of R 1) Assoc w R UP from AwRI to AwR yes 4 +Amikacin rrs n.1489C>T rrs_n.1489C>T 1 non_coding_transcript_exon_variant 1473334 1 2 1 1 1 1 2459 21977 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.9999544999545 0.999746516336938 0.999998848039248 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 8.93737291581943 0.113810496005924 697.318539256027 0.191196488852352 72.5 1832 False False 8.93737291581943 0.113810496005924 697.318539256027 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin rrs n.1491T>A rrs_n.1491T>A 1 non_coding_transcript_exon_variant 1473336 1 1 0 1 1 4 2459 21974 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999817999817999 0.999534073414941 0.999950408920832 0.2 0.00505076337946806 0.716417936118089 0 0 0.975 0 0 0.602364635616474 0 0 346.6435176627 1 662.5 1832 False False 2.23403822692151 0.045345258756558 22.5860023464291 0 0 0.00149902964335061 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 1110 7771 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.999742699086581 0.999070852951501 0.999968838146642 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 271.914335788577 1 267 981 False False 0 0 0 0 0 0 0 3.50045045045045 0.0592795803100707 67.3732765257098 0 0 0.00331779872508707 0.999742699086581 0.999070852951501 0.999968838146642 2 3) Uncertain significance No change no 1 +Amikacin rrs n.1491T>C rrs_n.1491T>C 1 non_coding_transcript_exon_variant 1473336 0 0 0 0 2 1 2458 21977 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.9999544999545 0.999746516336938 0.999998848039248 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 1484 1832 False False 17.8820179007323 0.930367849464557 1047.07427525324 0 0 0.00149963904330158 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1500A>T rrs_n.1500A>T 1 non_coding_transcript_exon_variant 1473345 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.1503C>T rrs_n.1503C>T 1 non_coding_transcript_exon_variant 1473348 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.1507C>T rrs_n.1507C>T 1 non_coding_transcript_exon_variant 1473352 NA 0 0 0 2 13 2458 21965 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.999408499408499 0.998988728376916 0.999685014453566 0.133333333333333 0.0165759134400836 0.404602696603372 NA NA NA 0 0 0.24705263800047 NA NA NA NA 1340 1832 False True 1.37478875884083 0.150562265718158 6.0779977845052 0 0 0.00149963904330158 0.999408499408499 0.998988728376916 0.999685014453566 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 1 10 1110 7763 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.998713495432908 0.997635349133423 0.999382904111848 0.0909090909090909 0.00229897221381426 0.412779916988382 NA NA NA 0 0 0.30849710781876 NA NA NA NA 608 981 False True 1 1 1 0 0 0 0 0.699369369369369 0.0161009855007121 4.92458323645355 0 0 0.00331779872508707 0.998713495432908 0.997635349133423 0.999382904111848 126 5) Not assoc w R New NotAwR yes 5 +Amikacin rrs n.1515T>C rrs_n.1515T>C 1 non_coding_transcript_exon_variant 1473360 0 0 0 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1427 1832 False False Inf 0.22908065008664 Inf 0 0 0.00149902964335061 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1110 7773 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 1 0.999525536566873 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 689 981 False False 0 0 0 0 0 0 0 Inf 0.179394825906045 Inf 0 0 0.00331779872508707 1 0.999525536566873 1 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.1519G>A rrs_n.1519G>A 1 non_coding_transcript_exon_variant 1473364 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.1523G>A rrs_n.1523G>A 1 non_coding_transcript_exon_variant 1473368 1 4 1 3 1 3 2459 21975 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.9998634998635 0.999601141012814 0.999971849505602 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 2.97885319235461 0.0567200675769732 37.1234870649317 0.345848866503538 87.5 1832 False False 2.97885319235461 0.0567200675769732 37.1234870649317 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.160dupT rrs_n.160dupT 1 non_coding_transcript_exon_variant 1472004 1 4 2 2 2 2 2458 21976 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.999908999909 0.999671315452743 0.999988979276808 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 8.94060211554109 0.647679042113151 123.448658884577 0.0529320449515396 23 1832 False False 8.94060211554109 0.647679042113151 123.448658884577 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 1109 7773 0.0018001800180018 0.000218084550259369 0.00648759665094944 1 0.999525536566873 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 1.31458832505494 Inf 0.0156267558099203 9 981 False False 0 0 0 0 0 0 0 Inf 1.31458832505494 Inf 0.0018001800180018 0.000218084550259369 0.00648759665094944 1 0.999525536566873 1 1 3) Uncertain significance No change no 1 +Amikacin rrs n.165C>A rrs_n.165C>A 1 non_coding_transcript_exon_variant 1472010 0 0 0 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1397 1832 False False Inf 0.22908065008664 Inf 0 0 0.00149902964335061 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1110 7773 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 1 0.999525536566873 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 661 981 False False 0 0 0 0 0 0 0 Inf 0.179394825906045 Inf 0 0 0.00331779872508707 1 0.999525536566873 1 1 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.169T>C rrs_n.169T>C 1 non_coding_transcript_exon_variant 1472014 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.16T>A rrs_n.16T>A 1 non_coding_transcript_exon_variant 1471861 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Amikacin rrs n.16T>C rrs_n.16T>C 1 non_coding_transcript_exon_variant 1471861 1 2 0 2 1 3 2459 21975 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.9998634998635 0.999601141012814 0.999971849505602 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 47.5704345304069 1 662.5 1832 False False 2.97885319235461 0.0567200675769732 37.1234870649317 0 0 0.00149902964335061 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 2 3) Uncertain significance No change no 1 +Amikacin rrs n.16T>G rrs_n.16T>G 1 non_coding_transcript_exon_variant 1471861 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1327 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.170A>G rrs_n.170A>G 1 non_coding_transcript_exon_variant 1472015 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin rrs n.178G>A rrs_n.178G>A 1 non_coding_transcript_exon_variant 1472023 1 1 1 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.22908065008664 Inf 0.100662902037809 42.5 1832 False False Inf 0.22908065008664 Inf 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1110 7773 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 1 0.999525536566873 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.179394825906045 Inf 0.125056280954525 25.5 981 False False 0 0 0 0 0 0 0 Inf 0.179394825906045 Inf 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 1 0.999525536566873 1 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.179G>T rrs_n.179G>T 1 non_coding_transcript_exon_variant 1472024 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.17T>G rrs_n.17T>G 1 non_coding_transcript_exon_variant 1471862 1 9 0 9 2 11 2458 21967 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.999499499499499 0.999104643231992 0.999750126319878 0.153846153846153 0.0192066719825284 0.454471055676557 0 0 0.336267116879942 0 0 0.284914152918154 0 0 4.53070831820375 0.612252529517296 122 1832 False False 1.62489829129373 0.174890324170057 7.45134037050451 0 0 0.00149963904330158 0.999499499499499 0.999104643231992 0.999750126319878 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 5 1110 7768 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.999356747716454 0.998499507558406 0.999791105797204 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.707598226178713 0 0 0.521823750104981 0 0 16.9453704248058 1 75.5 981 False False 0 0 0 0 0 0 0 1.39963963963963 0.0295658812501739 12.524223051576 0 0 0.00331779872508707 0.999356747716454 0.998499507558406 0.999791105797204 8 3) Uncertain significance No change no 1 +Amikacin rrs n.180A>C rrs_n.180A>C 1 non_coding_transcript_exon_variant 1472025 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.181C>T rrs_n.181C>T 1 non_coding_transcript_exon_variant 1472026 0 0 0 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1613 1832 False False Inf 0.22908065008664 Inf 0 0 0.00149902964335061 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1110 7773 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 1 0.999525536566873 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 869 981 False False 0 0 0 0 0 0 0 Inf 0.179394825906045 Inf 0 0 0.00331779872508707 1 0.999525536566873 1 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.182_200dupCACGGGATGCATGTCTTGT rrs_n.182_200dupCACGGGATGCATGTCTTGT 1 non_coding_transcript_exon_variant 1472026 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.182C>G rrs_n.182C>G 1 non_coding_transcript_exon_variant 1472027 1 2 0 2 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 47.551166952306 1 165 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin rrs n.184C>T rrs_n.184C>T 1 non_coding_transcript_exon_variant 1472029 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1292 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 560 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.185G>A rrs_n.185G>A 1 non_coding_transcript_exon_variant 1472030 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1379 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 643 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.186G>C rrs_n.186G>C 1 non_coding_transcript_exon_variant 1472031 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1466 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 728 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.187G>A rrs_n.187G>A 1 non_coding_transcript_exon_variant 1472032 1 2 0 2 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 47.551166952306 1 165 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 37.2577954991549 1 267 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 NA 3) Uncertain significance No change no 1 +Amikacin rrs n.188A>C rrs_n.188A>C 1 non_coding_transcript_exon_variant 1472033 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1341 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 609 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.190G>T rrs_n.190G>T 1 non_coding_transcript_exon_variant 1472035 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1305 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 574 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.195T>G rrs_n.195T>G 1 non_coding_transcript_exon_variant 1472040 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1507 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 768 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.196C>T rrs_n.196C>T 1 non_coding_transcript_exon_variant 1472041 1 2 0 2 0 5 2460 21973 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 0 0 0.521823750104981 0 0 0.841886116991581 0 0 0.521823750104981 0 0 47.5468558639646 1 662.5 1832 False False 0 0 9.75275991328737 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 4 1111 7769 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 271.601013915947 1 75.5 981 False False 0 0 0 0 0 0 0 0 0 10.6044836876068 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 1 3) Uncertain significance No change no 1 +Amikacin rrs n.197T>C rrs_n.197T>C 1 non_coding_transcript_exon_variant 1472042 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1547 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 804 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.197T>G rrs_n.197T>G 1 non_coding_transcript_exon_variant 1472042 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1625 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 880 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.198T>A rrs_n.198T>A 1 non_coding_transcript_exon_variant 1472043 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1236 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 509 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.-2_-1insGTTTTGTTTGGAGA rrs_n.-2_-1insGTTTTGTTTGGAGA 1 upstream_gene_variant 1471844 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1351 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Amikacin rrs n.-20_-19insTCCAAAGGGA rrs_n.-20_-19insTCCAAAGGGA 1 upstream_gene_variant 1471826 1 5 0 5 0 5 2460 21973 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 9.75275991328737 1 662.5 1832 False False 0 0 9.75275991328737 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin rrs n.200T>A rrs_n.200T>A 1 non_coding_transcript_exon_variant 1472045 1 5 0 5 0 7 2460 21971 0 0 0.00149842073847528 0.999681499681499 0.999343878425726 0.999871937071415 0 0 0.409616397225003 0 0 0.521823750104981 0 0 0.409616397225003 0 0 9.75187230990876 1 662.5 1832 False False 0 0 6.20059597931892 0 0 0.00149842073847528 0.999681499681499 0.999343878425726 0.999871937071415 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 5 1111 7768 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 16.930217557563 1 267 981 False False 0 0 0 0 0 0 0 0 0 7.63947436138835 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 7 3) Uncertain significance No change no 1 +Amikacin rrs n.203T>C rrs_n.203T>C 1 non_coding_transcript_exon_variant 1472048 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1237 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 510 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin rrs n.204G>A rrs_n.204G>A 1 non_coding_transcript_exon_variant 1472049 1 5 0 5 0 5 2460 21973 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 9.75275991328737 1 662.5 1832 False False 0 0 9.75275991328737 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 1111 7768 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 7.63947436138835 1 75.5 981 False False 0 0 0 0 0 0 0 0 0 7.63947436138835 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 2 3) Uncertain significance No change no 1 +Amikacin rrs n.205G>C rrs_n.205G>C 1 non_coding_transcript_exon_variant 1472050 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1398 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 662 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.211_212delGC rrs_n.211_212delGC 1 non_coding_transcript_exon_variant 1472053 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1371 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 637 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 2 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.212C>T rrs_n.212C>T 1 non_coding_transcript_exon_variant 1472057 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin rrs n.213T>A rrs_n.213T>A 1 non_coding_transcript_exon_variant 1472058 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin rrs n.213T>C rrs_n.213T>C 1 non_coding_transcript_exon_variant 1472058 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin rrs n.213T>G rrs_n.213T>G 1 non_coding_transcript_exon_variant 1472058 1 5 0 5 0 5 2460 21973 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 9.75275991328737 1 662.5 1832 False False 0 0 9.75275991328737 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin rrs n.216A>T rrs_n.216A>T 1 non_coding_transcript_exon_variant 1472061 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1328 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 596 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 2 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.225G>C rrs_n.225G>C 1 non_coding_transcript_exon_variant 1472070 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.230A>G rrs_n.230A>G 1 non_coding_transcript_exon_variant 1472075 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1342 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 610 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 4 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.236C>G rrs_n.236C>G 1 non_coding_transcript_exon_variant 1472081 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.239C>A rrs_n.239C>A 1 non_coding_transcript_exon_variant 1472084 1 2 1 1 1 1 2459 21977 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.9999544999545 0.999746516336938 0.999998848039248 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 8.93737291581943 0.113810496005924 697.318539256027 0.191196488852352 72.5 1832 False False 8.93737291581943 0.113810496005924 697.318539256027 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.23T>C rrs_n.23T>C 1 non_coding_transcript_exon_variant 1471868 1 1 0 1 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 346.519051274799 1 662.5 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin rrs n.23T>G rrs_n.23T>G 1 non_coding_transcript_exon_variant 1471868 1 3 0 3 1 3 2459 21975 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.9998634998635 0.999601141012814 0.999971849505602 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 21.6347237132381 1 165 1832 False False 2.97885319235461 0.0567200675769732 37.1234870649317 0 0 0.00149902964335061 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 1110 7771 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.999742699086581 0.999070852951501 0.999968838146642 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 37.2961498596314 1 267 981 False False 0 0 0 0 0 0 0 3.50045045045045 0.0592795803100707 67.3732765257098 0 0 0.00331779872508707 0.999742699086581 0.999070852951501 0.999968838146642 1 3) Uncertain significance No change no 1 +Amikacin rrs n.246_247dupGC rrs_n.246_247dupGC 1 non_coding_transcript_exon_variant 1472090 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1359 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.247C>T rrs_n.247C>T 1 non_coding_transcript_exon_variant 1472092 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Amikacin rrs n.24G>A rrs_n.24G>A 1 non_coding_transcript_exon_variant 1471869 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Amikacin rrs n.257G>A rrs_n.257G>A 1 non_coding_transcript_exon_variant 1472102 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1428 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 690 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 9 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.259dupG rrs_n.259dupG 1 non_coding_transcript_exon_variant 1472100 1 2 0 2 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 47.551166952306 1 165 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.259G>A rrs_n.259G>A 1 non_coding_transcript_exon_variant 1472104 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.-25C>A rrs_n.-25C>A 1 upstream_gene_variant 1471821 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.261G>A rrs_n.261G>A 1 non_coding_transcript_exon_variant 1472106 NA 0 0 0 0 7 2460 21971 0 0 0.00149842073847528 0.999681499681499 0.999343878425726 0.999871937071415 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1399 1832 False True 0 0 6.20059597931892 0 0 0.00149842073847528 0.999681499681499 0.999343878425726 0.999871937071415 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 7 1111 7766 0 0 0.00331481736263177 0.999099446803036 0.998145402056424 0.999637856686565 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 663 981 False True 0 1 1 0 0 0 0 0 0 4.85661817639599 0 0 0.00331481736263177 0.999099446803036 0.998145402056424 0.999637856686565 70 5) Not assoc w R New NotAwR yes 5 +Amikacin rrs n.262A>G rrs_n.262A>G 1 non_coding_transcript_exon_variant 1472107 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1380 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 644 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 6 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.263C>T rrs_n.263C>T 1 non_coding_transcript_exon_variant 1472108 1 0 0 0 0 5 2460 21973 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1413 1832 False False 0 0 9.75275991328737 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 1111 7768 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 676 981 False False 0 0 0 0 0 0 0 0 0 7.63947436138835 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 70 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.267C>T rrs_n.267C>T 1 non_coding_transcript_exon_variant 1472112 1 0 0 0 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1626 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1111 7769 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 881 981 False False 0 0 0 0 0 0 0 0 0 10.6044836876068 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 32 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.268T>C rrs_n.268T>C 1 non_coding_transcript_exon_variant 1472113 1 3 0 3 0 9 2460 21969 0 0 0.00149842073847528 0.999590499590499 0.999222783640785 0.999812733785825 0 0 0.336267116879942 0 0 0.707598226178713 0 0 0.336267116879942 0 0 21.620033668413 1 662.5 1832 False False 0 0 4.52743474605681 0 0 0.00149842073847528 0.999590499590499 0.999222783640785 0.999812733785825 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 9 1111 7764 0 0 0.00331481736263177 0.998842145889618 0.997803175208698 0.999470423012169 0 0 0.336267116879942 0 0 0.707598226178713 0 0 0.336267116879942 0 0 16.9215640850582 1 267 981 False False 0 0 0 0 0 0 0 0 0 3.54586915871032 0 0 0.00331481736263177 0.998842145889618 0.997803175208698 0.999470423012169 15 3) Uncertain significance No change no 1 +Amikacin rrs n.273A>T rrs_n.273A>T 1 non_coding_transcript_exon_variant 1472118 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.277G>A rrs_n.277G>A 1 non_coding_transcript_exon_variant 1472122 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1343 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 611 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 14 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.278A>G rrs_n.278A>G 1 non_coding_transcript_exon_variant 1472123 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1266 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 537 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 3 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.279C>T rrs_n.279C>T 1 non_coding_transcript_exon_variant 1472124 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1267 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 538 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 37 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.-27C>A rrs_n.-27C>A 1 upstream_gene_variant 1471819 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1259 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin rrs n.282C>T rrs_n.282C>T 1 non_coding_transcript_exon_variant 1472127 1 0 0 0 0 12 2460 21966 0 0 0.00149842073847528 0.999453999453999 0.999046441372309 0.999717842739244 0 0 0.264648469397051 NA NA NA 0 0 0.264648469397051 NA NA NA NA 1414 1832 False False 0 0 3.21614145803178 0 0 0.00149842073847528 0.999453999453999 0.999046441372309 0.999717842739244 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 9 1111 7764 0 0 0.00331481736263177 0.998842145889618 0.997803175208698 0.999470423012169 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 677 981 False False 0 0 0 0 0 0 0 0 0 3.54586915871032 0 0 0.00331481736263177 0.998842145889618 0.997803175208698 0.999470423012169 54 3) Uncertain significance No change no 1 +Amikacin rrs n.284G>C rrs_n.284G>C 1 non_coding_transcript_exon_variant 1472129 1 0 0 0 0 11 2460 21967 0 0 0.00149842073847528 0.999499499499499 0.999104643231992 0.999750126319878 0 0 0.284914152918154 NA NA NA 0 0 0.284914152918154 NA NA NA NA 1329 1832 False False 0 0 3.56038548490505 0 0 0.00149842073847528 0.999499499499499 0.999104643231992 0.999750126319878 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 9 1111 7764 0 0 0.00331481736263177 0.998842145889618 0.997803175208698 0.999470423012169 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 597 981 False False 0 0 0 0 0 0 0 0 0 3.54586915871032 0 0 0.00331481736263177 0.998842145889618 0.997803175208698 0.999470423012169 50 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.287A>G rrs_n.287A>G 1 non_coding_transcript_exon_variant 1472132 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin rrs n.-28G>A rrs_n.-28G>A 1 upstream_gene_variant 1471818 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1525 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 784 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.292G>A rrs_n.292G>A 1 non_coding_transcript_exon_variant 1472137 NA 0 0 0 2 13 2458 21965 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.999408499408499 0.998988728376916 0.999685014453566 0.133333333333333 0.0165759134400836 0.404602696603372 NA NA NA 0 0 0.24705263800047 NA NA NA NA 1589 1832 False True 1.37478875884083 0.150562265718158 6.0779977845052 0 0 0.00149963904330158 0.999408499408499 0.998988728376916 0.999685014453566 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 1 11 1110 7762 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.998584844976199 0.99746931080593 0.99929335470516 0.0833333333333333 0.00210759323186022 0.384796165150944 NA NA NA 0 0 0.284914152918154 NA NA NA NA 844 981 False True 1 1 1 0 0 0 0 0.635708435708435 0.0147590703488201 4.38167898705035 0 0 0.00331779872508707 0.998584844976199 0.99746931080593 0.99929335470516 99 5) Not assoc w R New NotAwR yes 5 +Amikacin rrs n.297A>C rrs_n.297A>C 1 non_coding_transcript_exon_variant 1472142 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.298_299insT rrs_n.298_299insT 1 non_coding_transcript_exon_variant 1472143 1 3 0 3 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 21.6259333410942 1 662.5 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 37.2625869115887 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 NA 3) Uncertain significance No change no 1 +Amikacin rrs n.300_301insT rrs_n.300_301insT 1 non_coding_transcript_exon_variant 1472145 1 1 1 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.22908065008664 Inf 0.100662902037809 42.5 1832 False False Inf 0.22908065008664 Inf 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1110 7773 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 1 0.999525536566873 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.179394825906045 Inf 0.125056280954525 25.5 981 False False 0 0 0 0 0 0 0 Inf 0.179394825906045 Inf 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 1 0.999525536566873 1 1 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.303T>C rrs_n.303T>C 1 non_coding_transcript_exon_variant 1472148 1 0 0 0 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1451 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1111 7769 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 713 981 False False 0 0 0 0 0 0 0 0 0 10.6044836876068 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 8 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.304_305dupGT rrs_n.304_305dupGT 1 non_coding_transcript_exon_variant 1472146 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1508 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 769 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin rrs n.305T>A rrs_n.305T>A 1 non_coding_transcript_exon_variant 1472150 NA 0 0 0 2 23 2458 21955 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.998953498953498 0.998430145857126 0.999336496079682 0.08 0.00983959001879751 0.260305842105214 NA NA NA 0 0 0.148185128915224 NA NA NA NA 1548 1832 False True 0.776700746453461 0.0887086124155599 3.14649104642921 0 0 0.00149963904330158 0.998953498953498 0.998430145857126 0.999336496079682 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 1 21 1110 7752 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.997298340409108 0.995873175693845 0.998326876273275 0.0454545454545454 0.00115014752657357 0.228444397667633 NA NA NA 0 0 0.161097615219079 NA NA NA NA 805 981 False True 1 1 1 0 0 0 0 0.332561132561132 0.00803771330611411 2.07209808994618 0 0 0.00331779872508707 0.997298340409108 0.995873175693845 0.998326876273275 222 5) Not assoc w R UP from Uncertain to NotAwR yes 4 +Amikacin rrs n.306C>A rrs_n.306C>A 1 non_coding_transcript_exon_variant 1472151 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1494 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 755 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 15 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.306C>T rrs_n.306C>T 1 non_coding_transcript_exon_variant 1472151 1 1 0 1 2 13 2458 21965 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.999408499408499 0.998988728376916 0.999685014453566 0.133333333333333 0.0165759134400836 0.404602696603372 0 0 0.975 0 0 0.24705263800047 0 0 346.642521940336 1 662.5 1832 False True 1.37478875884083 0.150562265718158 6.0779977845052 0 0 0.00149963904330158 0.999408499408499 0.998988728376916 0.999685014453566 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 1 10 1110 7763 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.998713495432908 0.997635349133423 0.999382904111848 0.0909090909090909 0.00229897221381426 0.412779916988382 NA NA NA 0 0 0.30849710781876 NA NA NA NA 824 981 False True 1 1 1 0 0 0 0 0.699369369369369 0.0161009855007121 4.92458323645355 0 0 0.00331779872508707 0.998713495432908 0.997635349133423 0.999382904111848 89 5) Not assoc w R UP from Uncertain to NotAwR yes 4 +Amikacin rrs n.307C>T rrs_n.307C>T 1 non_coding_transcript_exon_variant 1472152 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin rrs n.315C>T rrs_n.315C>T 1 non_coding_transcript_exon_variant 1472160 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1640 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 895 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 57 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.319G>A rrs_n.319G>A 1 non_coding_transcript_exon_variant 1472164 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1440 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 703 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 31 3) Uncertain significance No change no 1 +Amikacin rrs n.324A>C rrs_n.324A>C 1 non_coding_transcript_exon_variant 1472169 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin rrs n.327T>C rrs_n.327T>C 1 non_coding_transcript_exon_variant 1472172 NA 0 0 0 2 35 2458 21943 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.998407498407498 0.997785905018943 0.998890521362752 0.054054054054054 0.00661457041152882 0.181949118377749 NA NA NA 0 0 0.100032435572105 NA NA NA NA 1372 1832 False True 0.510124375217947 0.0594123905132907 1.98762291507056 0 0 0.00149963904330158 0.998407498407498 0.997785905018943 0.998890521362752 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 1 33 1110 7740 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.995754534928599 0.994042908633278 0.997075869271829 0.0294117647058823 0.00074436423469026 0.153267669560317 NA NA NA 0 0 0.105762810074579 NA NA NA NA 638 981 False True 0 1 1 0 0 0 0 0.211302211302211 0.00519312755327267 1.26498474807912 0 0 0.00331779872508707 0.995754534928599 0.994042908633278 0.997075869271829 230 5) Not assoc w R UP from Uncertain to NotAwR yes 4 +Amikacin rrs n.32A>G rrs_n.32A>G 1 non_coding_transcript_exon_variant 1471877 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance No change no 1 +Amikacin rrs n.-32T>G rrs_n.-32T>G 1 upstream_gene_variant 1471814 1 5 0 5 0 5 2460 21973 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 9.75275991328737 1 662.5 1832 False False 0 0 9.75275991328737 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 1111 7768 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 7.63947436138835 1 75.5 981 False False 0 0 0 0 0 0 0 0 0 7.63947436138835 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 NA 3) Uncertain significance No change no 1 +Amikacin rrs n.330G>T rrs_n.330G>T 1 non_coding_transcript_exon_variant 1472175 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.332C>T rrs_n.332C>T 1 non_coding_transcript_exon_variant 1472177 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1252 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 525 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 38 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.333C>T rrs_n.333C>T 1 non_coding_transcript_exon_variant 1472178 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin rrs n.336G>A rrs_n.336G>A 1 non_coding_transcript_exon_variant 1472181 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1590 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 845 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 4 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.33C>T rrs_n.33C>T 1 non_coding_transcript_exon_variant 1471878 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1238 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 511 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 37 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.340C>T rrs_n.340C>T 1 non_coding_transcript_exon_variant 1472185 1 1 0 1 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 346.503368577436 1 662.5 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 678 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 1 3) Uncertain significance No change no 1 +Amikacin rrs n.344C>T rrs_n.344C>T 1 non_coding_transcript_exon_variant 1472189 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.349G>A rrs_n.349G>A 1 non_coding_transcript_exon_variant 1472194 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 3) Uncertain significance No change no 1 +Amikacin rrs n.-34C>A rrs_n.-34C>A 1 upstream_gene_variant 1471812 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.358G>A rrs_n.358G>A 1 non_coding_transcript_exon_variant 1472203 0 0 0 0 2 14 2458 21964 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.999362999362999 0.998931451908832 0.999651703457902 0.125 0.0155136038154138 0.383476236849263 NA NA NA 0 0 0.231635761650116 NA NA NA NA 1344 1832 False True 1.27653144252005 0.14074898208514 5.56220221272253 0 0 0.00149963904330158 0.999362999362999 0.998931451908832 0.999651703457902 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 1 12 1110 7761 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.99845619451949 0.997304837007313 0.999202046759043 0.0769230769230769 0.00194562849734675 0.360297435267877 NA NA NA 0 0 0.264648469397051 NA NA NA NA 612 981 False True 1 1 1 0 0 0 0 0.582657657657657 0.0136211353314299 3.94507356448373 0 0 0.00331779872508707 0.99845619451949 0.997304837007313 0.999202046759043 120 5) Not assoc w R UP from Uncertain to NotAwR yes 4 +Amikacin rrs n.358G>T rrs_n.358G>T 1 non_coding_transcript_exon_variant 1472203 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1306 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.365A>C rrs_n.365A>C 1 non_coding_transcript_exon_variant 1472210 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1557 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 813 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 36 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.365A>G rrs_n.365A>G 1 non_coding_transcript_exon_variant 1472210 1 1 0 1 2 1 2458 21977 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.9999544999545 0.999746516336938 0.999998848039248 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 346.830866100726 1 165 1832 False False 17.8820179007323 0.930367849464557 1047.07427525324 0 0 0.00149963904330158 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.368G>C rrs_n.368G>C 1 non_coding_transcript_exon_variant 1472213 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1485 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 745 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 56 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.370A>G rrs_n.370A>G 1 non_coding_transcript_exon_variant 1472215 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1345 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 613 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 38 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.377G>A rrs_n.377G>A 1 non_coding_transcript_exon_variant 1472222 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1400 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 664 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 20 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.378C>G rrs_n.378C>G 1 non_coding_transcript_exon_variant 1472223 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1486 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 746 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 3 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.37C>T rrs_n.37C>T 1 non_coding_transcript_exon_variant 1471882 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.380C>A rrs_n.380C>A 1 non_coding_transcript_exon_variant 1472225 1 0 0 0 0 7 2460 21971 0 0 0.00149842073847528 0.999681499681499 0.999343878425726 0.999871937071415 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1268 1832 False False 0 0 6.20059597931892 0 0 0.00149842073847528 0.999681499681499 0.999343878425726 0.999871937071415 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 7 1111 7766 0 0 0.00331481736263177 0.999099446803036 0.998145402056424 0.999637856686565 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 539 981 False False 0 0 0 0 0 0 0 0 0 4.85661817639599 0 0 0.00331481736263177 0.999099446803036 0.998145402056424 0.999637856686565 109 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.382A>C rrs_n.382A>C 1 non_coding_transcript_exon_variant 1472227 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.383G>C rrs_n.383G>C 1 non_coding_transcript_exon_variant 1472228 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1467 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 729 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 3 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.384C>T rrs_n.384C>T 1 non_coding_transcript_exon_variant 1472229 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1495 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 756 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 19 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.389T>C rrs_n.389T>C 1 non_coding_transcript_exon_variant 1472234 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1269 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 540 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 32 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.391C>G rrs_n.391C>G 1 non_coding_transcript_exon_variant 1472236 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1468 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 730 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 43 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.395G>A rrs_n.395G>A 1 non_coding_transcript_exon_variant 1472240 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1627 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 882 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 56 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.-40_-39insA rrs_n.-40_-39insA 1 upstream_gene_variant 1471806 1 2 0 2 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 47.5490114093265 1 662.5 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 737 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance No change no 1 +Amikacin rrs n.401G>A rrs_n.401G>A 1 non_coding_transcript_exon_variant 1472246 0 0 0 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1381 1832 False False Inf 0.22908065008664 Inf 0 0 0.00149902964335061 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1110 7773 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 1 0.999525536566873 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 645 981 False False 0 0 0 0 0 0 0 Inf 0.179394825906045 Inf 0 0 0.00331779872508707 1 0.999525536566873 1 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.406G>A rrs_n.406G>A 1 non_coding_transcript_exon_variant 1472251 1 1 0 1 0 16 2460 21962 0 0 0.00149842073847528 0.999271999271999 0.998818040931792 0.999583829243268 0 0 0.205907214207822 0 0 0.975 0 0 0.205907214207822 0 0 346.315175606327 1 662.5 1832 False True 0 0 2.31664784301595 0 0 0.00149842073847528 0.999271999271999 0.998818040931792 0.999583829243268 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 1 0 1 0 16 1111 7757 0 0 0.00331481736263177 0.997941592692654 0.996659422164099 0.998822998929686 0 0 0.205907214207822 0 0 0.975 0 0 0.205907214207822 0 0 271.183330247434 1 267 981 False True 0 1 1 0 0 0 0 0 0 1.81358991296359 0 0 0.00331481736263177 0.997941592692654 0.996659422164099 0.998822998929686 134 5) Not assoc w R UP from Uncertain to NotAwR yes 4 +Amikacin rrs n.408G>A rrs_n.408G>A 1 non_coding_transcript_exon_variant 1472253 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.414C>A rrs_n.414C>A 1 non_coding_transcript_exon_variant 1472259 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1532 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 788 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 46 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.414C>T rrs_n.414C>T 1 non_coding_transcript_exon_variant 1472259 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.415G>A rrs_n.415G>A 1 non_coding_transcript_exon_variant 1472260 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin rrs n.424G>A rrs_n.424G>A 1 non_coding_transcript_exon_variant 1472269 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin rrs n.433C>T rrs_n.433C>T 1 non_coding_transcript_exon_variant 1472278 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1628 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 883 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.434T>C rrs_n.434T>C 1 non_coding_transcript_exon_variant 1472279 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1293 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 561 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.440A>G rrs_n.440A>G 1 non_coding_transcript_exon_variant 1472285 1 1 0 1 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 346.534733964433 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 562 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin rrs n.441C>T rrs_n.441C>T 1 non_coding_transcript_exon_variant 1472286 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin rrs n.444T>G rrs_n.444T>G 1 non_coding_transcript_exon_variant 1472289 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1604 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 861 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 2 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.445C>G rrs_n.445C>G 1 non_coding_transcript_exon_variant 1472290 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1469 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 731 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 2 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.445C>T rrs_n.445C>T 1 non_coding_transcript_exon_variant 1472290 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1253 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 526 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.447A>G rrs_n.447A>G 1 non_coding_transcript_exon_variant 1472292 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin rrs n.453_464delGTCCGGGTTCTCinsCCCT rrs_n.453_464delGTCCGGGTTCTCinsCCCT 1 non_coding_transcript_exon_variant 1472298 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1583 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 840 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.454T>C rrs_n.454T>C 1 non_coding_transcript_exon_variant 1472299 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Amikacin rrs n.459G>A rrs_n.459G>A 1 non_coding_transcript_exon_variant 1472304 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.460T>C rrs_n.460T>C 1 non_coding_transcript_exon_variant 1472305 0 0 0 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1441 1832 False False Inf 0.22908065008664 Inf 0 0 0.00149902964335061 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin rrs n.462C>T rrs_n.462C>T 1 non_coding_transcript_exon_variant 1472307 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 37.2625869115887 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 2 3) Uncertain significance No change no 1 +Amikacin rrs n.469_476dupATTGACGG rrs_n.469_476dupATTGACGG 1 non_coding_transcript_exon_variant 1472310 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1533 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 789 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.469A>G rrs_n.469A>G 1 non_coding_transcript_exon_variant 1472314 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1614 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 870 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.470T>G rrs_n.470T>G 1 non_coding_transcript_exon_variant 1472315 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1442 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 704 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.474C>T rrs_n.474C>T 1 non_coding_transcript_exon_variant 1472319 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.47G>A rrs_n.47G>A 1 non_coding_transcript_exon_variant 1471892 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 12 3) Uncertain significance No change no 1 +Amikacin rrs n.492C>G rrs_n.492C>G 1 non_coding_transcript_exon_variant 1472337 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1591 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 846 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.492C>T rrs_n.492C>T 1 non_coding_transcript_exon_variant 1472337 1 745 9 736 12 785 2448 21193 0.0048780487804878 0.00252302251619196 0.00850545023157134 0.964282464282464 0.96174395157099 0.966697204406716 0.015056461731493 0.00780345839444874 0.0261527819248339 0.0120805369127516 0.00553846328583709 0.0228082930757979 0.0113350125944584 0.00519582705971327 0.0214079219592191 0.105863371163682 0.0481538167552509 0.202442599570473 1.80097273177829e-23 NA NA False True 0.132340452104408 0.0679562654066338 0.232966033900418 0.00366300366300366 0.00167628458213417 0.00694208454043832 0.964282464282464 0.96174395157099 0.966697204406716 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 216 3 213 3 229 1108 7544 0.0027002700270027 0.000557207149395569 0.00787087587058421 0.970539045413611 0.966534689611023 0.97418517495811 0.0129310344827586 0.00267467029494752 0.0373227980999256 0.0138888888888888 0.00287343248522941 0.0400504968300442 0.0129310344827586 0.00267467029494752 0.0373227980999256 0.0958966797172929 0.019584552290108 0.284930427318908 2.01228782388517e-09 NA NA False True 1 1 1 0 0 1 0 0.0891964750208881 0.0182283098665594 0.264784221501765 0.0027002700270027 0.000557207149395569 0.00787087587058421 0.970539045413611 0.966534689611023 0.97418517495811 414 Not assoc w R 5) Not assoc w R No change yes 1 +Amikacin rrs n.493A>G rrs_n.493A>G 1 non_coding_transcript_exon_variant 1472338 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1307 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 575 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 8 3) Uncertain significance No change no 1 +Amikacin rrs n.499C>T rrs_n.499C>T 1 non_coding_transcript_exon_variant 1472344 NA 0 0 0 0 19 2460 21959 0 0 0.00149842073847528 0.999135499135499 0.99865030256088 0.999479436294878 0 0 0.176466911806965 NA NA NA 0 0 0.176466911806965 NA NA NA NA 1401 1832 False True 0 0 1.91422395460261 0 0 0.00149842073847528 0.999135499135499 0.99865030256088 0.999479436294878 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 18 1111 7755 0 0 0.00331481736263177 0.997684291779235 0.996342642478027 0.998627005047973 0 0 0.185301968137852 NA NA NA 0 0 0.185301968137852 NA NA NA NA 665 981 False True 0 1 1 0 0 0 0 0 0 1.59041726002428 0 0 0.00331481736263177 0.997684291779235 0.996342642478027 0.998627005047973 96 5) Not assoc w R New NotAwR yes 5 +Amikacin rrs n.-4T>G rrs_n.-4T>G 1 upstream_gene_variant 1471842 1 31 0 31 0 31 2460 21947 0 0 0.00149842073847528 0.998589498589498 0.997998498131125 0.999041437774243 0 0 0.11218874692237 0 0 0.11218874692237 0 0 0.11218874692237 0 0 1.1282699517541 0.0686667556447468 27 1832 False False 0 0 1.1282699517541 0 0 0.00149842073847528 0.998589498589498 0.997998498131125 0.999041437774243 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 0 9 1111 7764 0 0 0.00331481736263177 0.998842145889618 0.997803175208698 0.999470423012169 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.336267116879942 0 0 3.54586915871032 0.61329084057404 55.5 981 False False 0 0 0 0 0 0 0 0 0 3.54586915871032 0 0 0.00331481736263177 0.998842145889618 0.997803175208698 0.999470423012169 56 3) Uncertain significance No change no 1 +Amikacin rrs n.5_6delGTinsTGG rrs_n.5_6delGTinsTGG 1 non_coding_transcript_exon_variant 1471850 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1415 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 679 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 5 3) Uncertain significance No change no 1 +Amikacin rrs n.5_6insC rrs_n.5_6insC 1 non_coding_transcript_exon_variant 1471850 1 4 0 4 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 13.5427650126618 1 662.5 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.500A>G rrs_n.500A>G 1 non_coding_transcript_exon_variant 1472345 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1570 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 825 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.504A>G rrs_n.504A>G 1 non_coding_transcript_exon_variant 1472349 1 1 0 1 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 346.519051274799 1 662.5 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 271.670627328402 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 NA 3) Uncertain significance No change no 1 +Amikacin rrs n.-50A>G rrs_n.-50A>G 1 upstream_gene_variant 1471796 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1420 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.513C>T rrs_n.513C>T 1 non_coding_transcript_exon_variant 1472358 1 12 2 10 3 11 2457 21967 0.00121951219512195 0.00025156337591866 0.00355975660270706 0.999499499499499 0.999104643231992 0.999750126319878 0.214285714285714 0.0465792878898673 0.507975677048471 0.166666666666666 0.0208625254600923 0.484137748685967 0.153846153846153 0.0192066719825284 0.454471055676557 1.78811558811558 0.190374249375389 8.39710212100057 0.343907384883045 86 1832 False False 2.43833943833943 0.436475869927263 9.23648934897477 0.000813338755591703 9.85142783100216e-05 0.00293493961754082 0.999499499499499 0.999104643231992 0.999750126319878 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 14 3) Uncertain significance No change no 1 +Amikacin rrs n.514A>C rrs_n.514A>C 1 non_coding_transcript_exon_variant 1472359 1 336 8 328 329 577 2131 21401 0.133739837398373 0.120528171606468 0.147829968177315 0.973746473746473 0.97154619201424 0.975820215998911 0.363134657836644 0.331756945607656 0.395405653736627 0.0238095238095238 0.0103340395718973 0.0463734920296494 0.0136752136752136 0.00592198156499708 0.0267670632560927 0.244943974545329 0.104741781678434 0.48933738014409 1.67606165149654e-06 NA NA False True 5.72625523854757 4.9494311450092 6.61641462295361 0.00374006545114539 0.00161603531532836 0.00735605154529339 0.973746473746473 0.97154619201424 0.975820215998911 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 154 1 153 99 241 1012 7532 0.0891089108910891 0.0730118095745216 0.10741907036754 0.968995239933101 0.964897490345376 0.972736128402862 0.291176470588235 0.243420983616557 0.34261257233679 0.00649350649350649 0.000164387837385843 0.0356470312906918 0.00413223140495867 0.000104613568876339 0.0228070248793185 0.0486450179544808 0.00122664535899291 0.275812730463972 1.64211404320066e-07 NA NA False True 0 1 1 0 0 1 0 3.05736965542125 2.37215126222696 3.91638951490671 0.000987166831194471 2.49925879607112e-05 0.00548774658964867 0.968995239933101 0.964897490345376 0.972736128402862 775 Not assoc w R 5) Not assoc w R No change yes 1 +Amikacin rrs n.514A>T rrs_n.514A>T 1 non_coding_transcript_exon_variant 1472359 1 10 0 10 0 15 2460 21963 0 0 0.00149842073847528 0.999317499317499 0.998874568358369 0.999617960830416 0 0 0.218019360910534 0 0 0.30849710781876 0 0 0.218019360910534 0 0 3.98590136288697 0.612510708743314 128 1832 False False 0 0 2.49100508208792 0 0 0.00149842073847528 0.999317499317499 0.998874568358369 0.999617960830416 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 8 1111 7765 0 0 0.00331481736263177 0.998970796346327 0.997973071099689 0.99955556151365 0 0 0.369416647552819 0 0 0.4592581264399 0 0 0.369416647552819 0 0 5.94388498248289 1 267 981 False False 0 0 0 0 0 0 0 0 0 4.10060236216416 0 0 0.00331481736263177 0.998970796346327 0.997973071099689 0.99955556151365 15 3) Uncertain significance No change no 1 +Amikacin rrs n.516C>T rrs_n.516C>T 1 non_coding_transcript_exon_variant 1472361 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.517C>T rrs_n.517C>T 1 non_coding_transcript_exon_variant 1472362 1 220 5 215 53 442 2407 21536 0.0215447154471544 0.0161791096494416 0.0280872296382952 0.97988897988898 0.977945559964419 0.981703972160847 0.107070707070707 0.08123767125042 0.137705481436605 0.0227272727272727 0.00741972133889208 0.0522380491360821 0.0111856823266219 0.00364166044371233 0.0259094208686304 0.20807528429677 0.0668141655837382 0.493903828423802 1.29116127662783e-05 NA NA False True 1.07285876224511 0.788634874828152 1.43388069947995 0.00207296849087893 0.000673419103902132 0.00483093283457855 0.97988897988898 0.977945559964419 0.981703972160847 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 102 3 99 43 269 1068 7504 0.0387038703870387 0.0281492038616075 0.0517820714341826 0.965393027145246 0.961086913182333 0.969345410113027 0.137820512820512 0.101569311045362 0.181122002727745 0.0294117647058823 0.00610697386242858 0.0835533418583559 0.0110294117647058 0.00228033101312488 0.0318924795387063 0.21291567358983 0.0431040507046512 0.642539315636741 0.00132930037551477 NA NA False True 0 0 0 1 0 1 0 1.12314996588836 0.78922303342053 1.56532738651561 0.00280112044817927 0.000578031315567923 0.00816404777215706 0.965393027145246 0.961086913182333 0.969345410113027 490 Not assoc w R 5) Not assoc w R No change yes 1 +Amikacin rrs n.51T>C rrs_n.51T>C 1 non_coding_transcript_exon_variant 1471896 NA 0 0 0 1 10 2459 21968 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999544999544999 0.999163397681526 0.999781788721324 0.0909090909090909 0.00229897221381426 0.412779916988382 NA NA NA 0 0 0.30849710781876 NA NA NA NA 1615 1832 False True 0.893371289141927 0.020577382163102 6.28488216182158 0 0 0.00149902964335061 0.999544999544999 0.999163397681526 0.999781788721324 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 8 1111 7765 0 0 0.00331481736263177 0.998970796346327 0.997973071099689 0.99955556151365 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 871 981 False True 1 1 1 0 0 0 0 0 0 4.10060236216416 0 0 0.00331481736263177 0.998970796346327 0.997973071099689 0.99955556151365 100 5) Not assoc w R New NotAwR yes 5 +Amikacin rrs n.529T>C rrs_n.529T>C 1 non_coding_transcript_exon_variant 1472374 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.-52T>G rrs_n.-52T>G 1 upstream_gene_variant 1471794 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1504 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 765 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin rrs n.533G>T rrs_n.533G>T 1 non_coding_transcript_exon_variant 1472378 NA 0 0 0 2 9 2458 21969 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.999590499590499 0.999222783640785 0.999812733785825 0.181818181818181 0.0228311982999596 0.517755852360172 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1605 1832 False True 1.98616761594792 0.208698486506856 9.60104394724998 0 0 0.00149963904330158 0.999590499590499 0.999222783640785 0.999812733785825 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 1 7 1110 7766 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.999099446803036 0.998145402056424 0.999637856686565 0.125 0.0031597235312519 0.526509670875206 NA NA NA 0 0 0.409616397225003 NA NA NA NA 862 981 False True 1 1 1 0 0 0 0 0.999485199485199 0.0221570004013934 7.79164585701028 0 0 0.00331779872508707 0.999099446803036 0.998145402056424 0.999637856686565 94 5) Not assoc w R New NotAwR yes 5 +Amikacin rrs n.534T>C rrs_n.534T>C 1 non_coding_transcript_exon_variant 1472379 NA 0 0 0 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1239 1832 False True 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 4 1111 7769 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 512 981 False True 0 1 1 0 0 0 0 0 0 10.6044836876068 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 65 5) Not assoc w R New NotAwR yes 5 +Amikacin rrs n.534T>G rrs_n.534T>G 1 non_coding_transcript_exon_variant 1472379 NA 0 0 0 2 10 2458 21968 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.999544999544999 0.999163397681526 0.999781788721324 0.166666666666666 0.0208625254600923 0.484137748685967 NA NA NA 0 0 0.30849710781876 NA NA NA NA 1496 1832 False True 1.78746948738812 0.190305480385834 8.39406757280947 0 0 0.00149963904330158 0.999544999544999 0.999163397681526 0.999781788721324 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 1 8 1110 7765 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.998970796346327 0.997973071099689 0.99955556151365 0.111111111111111 0.00280913674659921 0.482496514917337 NA NA NA 0 0 0.369416647552819 NA NA NA NA 757 981 False True 0 1 1 0 0 0 0 0.874436936936936 0.0196891061138737 6.5329210318286 0 0 0.00331779872508707 0.998970796346327 0.997973071099689 0.99955556151365 70 5) Not assoc w R New NotAwR yes 5 +Amikacin rrs n.535G>C rrs_n.535G>C 1 non_coding_transcript_exon_variant 1472380 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1330 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 598 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 40 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.537G>A rrs_n.537G>A 1 non_coding_transcript_exon_variant 1472382 NA 0 0 0 2 10 2458 21968 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.999544999544999 0.999163397681526 0.999781788721324 0.166666666666666 0.0208625254600923 0.484137748685967 NA NA NA 0 0 0.30849710781876 NA NA NA NA 1270 1832 False True 1.78746948738812 0.190305480385834 8.39406757280947 0 0 0.00149963904330158 0.999544999544999 0.999163397681526 0.999781788721324 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 1 8 1110 7765 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.998970796346327 0.997973071099689 0.99955556151365 0.111111111111111 0.00280913674659921 0.482496514917337 NA NA NA 0 0 0.369416647552819 NA NA NA NA 541 981 False True 0 1 1 0 0 0 0 0.874436936936936 0.0196891061138737 6.5329210318286 0 0 0.00331779872508707 0.998970796346327 0.997973071099689 0.99955556151365 84 5) Not assoc w R New NotAwR yes 5 +Amikacin rrs n.544G>A rrs_n.544G>A 1 non_coding_transcript_exon_variant 1472389 1 0 0 0 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1346 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 614 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 49 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.551A>T rrs_n.551A>T 1 non_coding_transcript_exon_variant 1472396 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1402 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 666 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 62 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.554A>G rrs_n.554A>G 1 non_coding_transcript_exon_variant 1472399 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1317 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 586 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.555C>T rrs_n.555C>T 1 non_coding_transcript_exon_variant 1472400 NA 0 0 0 2 23 2458 21955 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.998953498953498 0.998430145857126 0.999336496079682 0.08 0.00983959001879751 0.260305842105214 NA NA NA 0 0 0.148185128915224 NA NA NA NA 1429 1832 False True 0.776700746453461 0.0887086124155599 3.14649104642921 0 0 0.00149963904330158 0.998953498953498 0.998430145857126 0.999336496079682 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 1 21 1110 7752 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.997298340409108 0.995873175693845 0.998326876273275 0.0454545454545454 0.00115014752657357 0.228444397667633 NA NA NA 0 0 0.161097615219079 NA NA NA NA 691 981 False True 1 1 1 0 0 0 0 0.332561132561132 0.00803771330611411 2.07209808994618 0 0 0.00331779872508707 0.997298340409108 0.995873175693845 0.998326876273275 164 5) Not assoc w R New NotAwR yes 5 +Amikacin rrs n.556dupT rrs_n.556dupT 1 non_coding_transcript_exon_variant 1472400 1 1 0 1 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 346.534733964433 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 550 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin rrs n.55C>T rrs_n.55C>T 1 non_coding_transcript_exon_variant 1471900 0 0 0 0 1 9 2459 21969 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999590499590499 0.999222783640785 0.999812733785825 0.1 0.00252857854446178 0.445016117028195 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1331 1832 False False 0.992679951199674 0.0226387633018841 7.16949857929758 0 0 0.00149902964335061 0.999590499590499 0.999222783640785 0.999812733785825 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 8 1111 7765 0 0 0.00331481736263177 0.998970796346327 0.997973071099689 0.99955556151365 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 599 981 False False 0 0 0 0 0 0 0 0 0 4.10060236216416 0 0 0.00331481736263177 0.998970796346327 0.997973071099689 0.99955556151365 90 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.560C>T rrs_n.560C>T 1 non_coding_transcript_exon_variant 1472405 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 37.2625869115887 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 2 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.567A>C rrs_n.567A>C 1 non_coding_transcript_exon_variant 1472412 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1430 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 692 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 30 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.567A>G rrs_n.567A>G 1 non_coding_transcript_exon_variant 1472412 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1332 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 600 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 12 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.570T>G rrs_n.570T>G 1 non_coding_transcript_exon_variant 1472415 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1584 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 841 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 31 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.571C>T rrs_n.571C>T 1 non_coding_transcript_exon_variant 1472416 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1360 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 625 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 13 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.573T>C rrs_n.573T>C 1 non_coding_transcript_exon_variant 1472418 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1558 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 814 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 2 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.577T>C rrs_n.577T>C 1 non_coding_transcript_exon_variant 1472422 1 0 0 0 0 8 2460 21970 0 0 0.00149842073847528 0.999635999635999 0.999282900840091 0.999842837798826 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1616 1832 False False 0 0 5.2353912865109 0 0 0.00149842073847528 0.999635999635999 0.999282900840091 0.999842837798826 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 7 1111 7766 0 0 0.00331481736263177 0.999099446803036 0.998145402056424 0.999637856686565 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 872 981 False False 0 0 0 0 0 0 0 0 0 4.85661817639599 0 0 0.00331481736263177 0.999099446803036 0.998145402056424 0.999637856686565 42 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.580T>C rrs_n.580T>C 1 non_coding_transcript_exon_variant 1472425 1 1 0 1 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 346.503368577436 1 662.5 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 576 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 3 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.581T>G rrs_n.581T>G 1 non_coding_transcript_exon_variant 1472426 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1641 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 896 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.590T>C rrs_n.590T>C 1 non_coding_transcript_exon_variant 1472435 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1487 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 747 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 1 3) Uncertain significance No change no 1 +Amikacin rrs n.592T>A rrs_n.592T>A 1 non_coding_transcript_exon_variant 1472437 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1606 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 863 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.593dupT rrs_n.593dupT 1 non_coding_transcript_exon_variant 1472436 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin rrs n.593T>C rrs_n.593T>C 1 non_coding_transcript_exon_variant 1472438 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1497 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 758 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 NA 3) Uncertain significance No change no 1 +Amikacin rrs n.594C>T rrs_n.594C>T 1 non_coding_transcript_exon_variant 1472439 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1488 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 748 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.5G>T rrs_n.5G>T 1 non_coding_transcript_exon_variant 1471850 1 6 1 5 1 9 2459 21969 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999590499590499 0.999222783640785 0.999812733785825 0.1 0.00252857854446178 0.445016117028195 0.166666666666666 0.00421074451448947 0.641234578997674 0.1 0.00252857854446178 0.445016117028195 1.78682391215941 0.0377631681122492 15.976397887655 0.47099783228177 107 1832 False False 0.992679951199674 0.0226387633018841 7.16949857929758 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999590499590499 0.999222783640785 0.999812733785825 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 847 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 12 3) Uncertain significance No change no 1 +Amikacin rrs n.601T>A rrs_n.601T>A 1 non_coding_transcript_exon_variant 1472446 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1271 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 542 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.602C>T rrs_n.602C>T 1 non_coding_transcript_exon_variant 1472447 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1254 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 527 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.603T>C rrs_n.603T>C 1 non_coding_transcript_exon_variant 1472448 1 2 0 2 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 47.5490114093265 1 662.5 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 271.635820641185 1 75.5 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 1 3) Uncertain significance No change no 1 +Amikacin rrs n.605A>G rrs_n.605A>G 1 non_coding_transcript_exon_variant 1472450 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1521 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 780 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.606C>G rrs_n.606C>G 1 non_coding_transcript_exon_variant 1472451 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1452 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 714 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.607G>A rrs_n.607G>A 1 non_coding_transcript_exon_variant 1472452 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1498 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 759 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.613A>C rrs_n.613A>C 1 non_coding_transcript_exon_variant 1472458 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.616G>C rrs_n.616G>C 1 non_coding_transcript_exon_variant 1472461 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1403 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 667 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.617T>C rrs_n.617T>C 1 non_coding_transcript_exon_variant 1472462 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1347 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 615 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.619A>G rrs_n.619A>G 1 non_coding_transcript_exon_variant 1472464 1 0 0 0 0 6 2460 21972 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1642 1832 False False 0 0 7.5904311186467 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 1111 7767 0 0 0.00331481736263177 0.999228097259745 0.998320655545558 0.999716674296114 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 897 981 False False 0 0 0 0 0 0 0 0 0 5.94541565066903 0 0 0.00331481736263177 0.999228097259745 0.998320655545558 0.999716674296114 NA 3) Uncertain significance No change no 1 +Amikacin rrs n.619A>T rrs_n.619A>T 1 non_coding_transcript_exon_variant 1472464 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.626G>A rrs_n.626G>A 1 non_coding_transcript_exon_variant 1472471 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1470 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 732 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 2 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.628G>T rrs_n.628G>T 1 non_coding_transcript_exon_variant 1472473 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1308 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 577 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.629C>G rrs_n.629C>G 1 non_coding_transcript_exon_variant 1472474 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1272 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 543 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.633A>C rrs_n.633A>C 1 non_coding_transcript_exon_variant 1472478 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1617 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.637G>A rrs_n.637G>A 1 non_coding_transcript_exon_variant 1472482 1 4 0 4 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 13.5427650126618 1 662.5 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 1111 7769 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 10.6044836876068 1 267 981 False False 0 0 0 0 0 0 0 0 0 10.6044836876068 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.639A>C rrs_n.639A>C 1 non_coding_transcript_exon_variant 1472484 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1571 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 826 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.639A>T rrs_n.639A>T 1 non_coding_transcript_exon_variant 1472484 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1499 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 760 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.641A>G rrs_n.641A>G 1 non_coding_transcript_exon_variant 1472486 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1348 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 616 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.643dupT rrs_n.643dupT 1 non_coding_transcript_exon_variant 1472487 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 19 3) Uncertain significance No change no 1 +Amikacin rrs n.644A>G rrs_n.644A>G 1 non_coding_transcript_exon_variant 1472489 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.644A>T rrs_n.644A>T 1 non_coding_transcript_exon_variant 1472489 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1471 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 733 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 4 3) Uncertain significance No change no 1 +Amikacin rrs n.649A>G rrs_n.649A>G 1 non_coding_transcript_exon_variant 1472494 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1333 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 601 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 8 3) Uncertain significance No change no 1 +Amikacin rrs n.649A>T rrs_n.649A>T 1 non_coding_transcript_exon_variant 1472494 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1643 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 898 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.650C>T rrs_n.650C>T 1 non_coding_transcript_exon_variant 1472495 1 1 0 1 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 346.534733964433 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 790 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 2 3) Uncertain significance No change no 1 +Amikacin rrs n.651T>A rrs_n.651T>A 1 non_coding_transcript_exon_variant 1472496 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1509 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 770 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 3 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.651T>G rrs_n.651T>G 1 non_coding_transcript_exon_variant 1472496 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1382 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 646 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 3 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.652G>T rrs_n.652G>T 1 non_coding_transcript_exon_variant 1472497 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1294 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 563 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.653C>T rrs_n.653C>T 1 non_coding_transcript_exon_variant 1472498 1 0 0 0 0 5 2460 21973 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1500 1832 False False 0 0 9.75275991328737 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 1111 7768 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 761 981 False False 0 0 0 0 0 0 0 0 0 7.63947436138835 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 10 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.655G>C rrs_n.655G>C 1 non_coding_transcript_exon_variant 1472500 1 5 0 5 0 5 2460 21973 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 9.75275991328737 1 662.5 1832 False False 0 0 9.75275991328737 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 37.2625869115887 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 1 3) Uncertain significance No change no 1 +Amikacin rrs n.-65G>A rrs_n.-65G>A 1 upstream_gene_variant 1471781 1 6 0 6 0 6 2460 21972 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 7.5904311186467 1 662.5 1832 False False 0 0 7.5904311186467 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 7 3) Uncertain significance No change no 1 +Amikacin rrs n.660G>T rrs_n.660G>T 1 non_coding_transcript_exon_variant 1472505 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin rrs n.662C>G rrs_n.662C>G 1 non_coding_transcript_exon_variant 1472507 1 0 0 0 0 7 2460 21971 0 0 0.00149842073847528 0.999681499681499 0.999343878425726 0.999871937071415 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1559 1832 False False 0 0 6.20059597931892 0 0 0.00149842073847528 0.999681499681499 0.999343878425726 0.999871937071415 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 1111 7767 0 0 0.00331481736263177 0.999228097259745 0.998320655545558 0.999716674296114 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 815 981 False False 0 0 0 0 0 0 0 0 0 5.94541565066903 0 0 0.00331481736263177 0.999228097259745 0.998320655545558 0.999716674296114 41 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.662C>T rrs_n.662C>T 1 non_coding_transcript_exon_variant 1472507 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1318 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 587 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 2 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.663T>C rrs_n.663T>C 1 non_coding_transcript_exon_variant 1472508 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1416 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 680 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 1 3) Uncertain significance No change no 1 +Amikacin rrs n.66C>A rrs_n.66C>A 1 non_coding_transcript_exon_variant 1471911 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1618 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 873 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 27 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.672T>A rrs_n.672T>A 1 non_coding_transcript_exon_variant 1472517 NA 0 0 0 0 10 2460 21968 0 0 0.00149842073847528 0.999544999544999 0.999163397681526 0.999781788721324 0 0 0.30849710781876 NA NA NA 0 0 0.30849710781876 NA NA NA NA 1383 1832 False True 0 0 3.98680916993403 0 0 0.00149842073847528 0.999544999544999 0.999163397681526 0.999781788721324 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 8 1111 7765 0 0 0.00331481736263177 0.998970796346327 0.997973071099689 0.99955556151365 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 647 981 False True 1 1 1 0 0 0 0 0 0 4.10060236216416 0 0 0.00331481736263177 0.998970796346327 0.997973071099689 0.99955556151365 73 5) Not assoc w R New NotAwR yes 5 +Amikacin rrs n.673G>A rrs_n.673G>A 1 non_coding_transcript_exon_variant 1472518 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1510 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Amikacin rrs n.673G>C rrs_n.673G>C 1 non_coding_transcript_exon_variant 1472518 1 0 0 0 0 6 2460 21972 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1295 1832 False False 0 0 7.5904311186467 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 1111 7768 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 564 981 False False 0 0 0 0 0 0 0 0 0 7.63947436138835 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 4 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.673G>T rrs_n.673G>T 1 non_coding_transcript_exon_variant 1472518 1 0 0 0 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1534 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 791 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 66 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.-67T>C rrs_n.-67T>C 1 upstream_gene_variant 1471779 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin rrs n.685G>A rrs_n.685G>A 1 non_coding_transcript_exon_variant 1472530 NA 0 0 0 2 23 2458 21955 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.998953498953498 0.998430145857126 0.999336496079682 0.08 0.00983959001879751 0.260305842105214 NA NA NA 0 0 0.148185128915224 NA NA NA NA 1281 1832 False True 0.776700746453461 0.0887086124155599 3.14649104642921 0 0 0.00149963904330158 0.998953498953498 0.998430145857126 0.999336496079682 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 1 20 1110 7753 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.997426990865817 0.99602897969996 0.998427652722777 0.0476190476190476 0.00120488344836351 0.238159909936821 NA NA NA 0 0 0.168433470983085 NA NA NA NA 551 981 False True 1 1 1 0 0 0 0 0.349234234234234 0.00842160573418044 2.18802052143638 0 0 0.00331779872508707 0.997426990865817 0.99602897969996 0.998427652722777 161 5) Not assoc w R New NotAwR yes 5 +Amikacin rrs n.-68G>T rrs_n.-68G>T 1 upstream_gene_variant 1471778 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.692C>T rrs_n.692C>T 1 non_coding_transcript_exon_variant 1472537 0 0 0 0 2 13 2458 21965 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.999408499408499 0.998988728376916 0.999685014453566 0.133333333333333 0.0165759134400836 0.404602696603372 NA NA NA 0 0 0.24705263800047 NA NA NA NA 1511 1832 False False 1.37478875884083 0.150562265718158 6.0779977845052 0 0 0.00149963904330158 0.999408499408499 0.998988728376916 0.999685014453566 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 11 1110 7762 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.998584844976199 0.99746931080593 0.99929335470516 0.0833333333333333 0.00210759323186022 0.384796165150944 NA NA NA 0 0 0.284914152918154 NA NA NA NA 771 981 False False 0 0 0 0 0 0 0 0.635708435708435 0.0147590703488201 4.38167898705035 0 0 0.00331779872508707 0.998584844976199 0.99746931080593 0.99929335470516 141 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.696T>G rrs_n.696T>G 1 non_coding_transcript_exon_variant 1472541 0 0 0 0 2 9 2458 21969 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.999590499590499 0.999222783640785 0.999812733785825 0.181818181818181 0.0228311982999596 0.517755852360172 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1240 1832 False False 1.98616761594792 0.208698486506856 9.60104394724998 0 0 0.00149963904330158 0.999590499590499 0.999222783640785 0.999812733785825 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 7 1110 7766 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.999099446803036 0.998145402056424 0.999637856686565 0.125 0.0031597235312519 0.526509670875206 NA NA NA 0 0 0.409616397225003 NA NA NA NA 513 981 False False 0 0 0 0 0 0 0 0.999485199485199 0.0221570004013934 7.79164585701028 0 0 0.00331779872508707 0.999099446803036 0.998145402056424 0.999637856686565 38 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.698T>C rrs_n.698T>C 1 non_coding_transcript_exon_variant 1472543 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.699C>A rrs_n.699C>A 1 non_coding_transcript_exon_variant 1472544 1 0 0 0 0 7 2460 21971 0 0 0.00149842073847528 0.999681499681499 0.999343878425726 0.999871937071415 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1443 1832 False False 0 0 6.20059597931892 0 0 0.00149842073847528 0.999681499681499 0.999343878425726 0.999871937071415 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 1111 7768 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 705 981 False False 0 0 0 0 0 0 0 0 0 7.63947436138835 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 159 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.699C>G rrs_n.699C>G 1 non_coding_transcript_exon_variant 1472544 0 0 0 0 2 7 2458 21971 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.999681499681499 0.999343878425726 0.999871937071415 0.222222222222222 0.0281449734778982 0.600093573716312 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1522 1832 False False 2.55387655469022 0.2587089419725 13.4183971176954 0 0 0.00149963904330158 0.999681499681499 0.999343878425726 0.999871937071415 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 6 1110 7767 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.999228097259745 0.998320655545558 0.999716674296114 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA 0 0 0.4592581264399 NA NA NA NA 781 981 False False 0 0 0 0 0 0 0 1.16621621621621 0.0253312798003414 9.6261228731741 0 0 0.00331779872508707 0.999228097259745 0.998320655545558 0.999716674296114 11 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.699C>T rrs_n.699C>T 1 non_coding_transcript_exon_variant 1472544 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Amikacin rrs n.69A>G rrs_n.69A>G 1 non_coding_transcript_exon_variant 1471914 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1572 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 827 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.-69C>A rrs_n.-69C>A 1 upstream_gene_variant 1471777 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin rrs n.-69C>T rrs_n.-69C>T 1 upstream_gene_variant 1471777 1 2 0 2 0 5 2460 21973 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 0 0 0.521823750104981 0 0 0.841886116991581 0 0 0.521823750104981 0 0 47.5468558639646 1 662.5 1832 False False 0 0 9.75275991328737 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 5 1111 7768 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 0 0 0.521823750104981 0 0 0.841886116991581 0 0 0.521823750104981 0 0 37.2482126613481 1 267 981 False False 0 0 0 0 0 0 0 0 0 7.63947436138835 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 16 3) Uncertain significance No change no 1 +Amikacin rrs n.700A>T rrs_n.700A>T 1 non_coding_transcript_exon_variant 1472545 0 0 0 0 2 14 2458 21964 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.999362999362999 0.998931451908832 0.999651703457902 0.125 0.0155136038154138 0.383476236849263 NA NA NA 0 0 0.231635761650116 NA NA NA NA 1523 1832 False False 1.27653144252005 0.14074898208514 5.56220221272253 0 0 0.00149963904330158 0.999362999362999 0.998931451908832 0.999651703457902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 11 1110 7762 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.998584844976199 0.99746931080593 0.99929335470516 0.0833333333333333 0.00210759323186022 0.384796165150944 NA NA NA 0 0 0.284914152918154 NA NA NA NA 782 981 False False 0 0 0 0 0 0 0 0.635708435708435 0.0147590703488201 4.38167898705035 0 0 0.00331779872508707 0.998584844976199 0.99746931080593 0.99929335470516 174 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.703A>C rrs_n.703A>C 1 non_coding_transcript_exon_variant 1472548 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.704G>A rrs_n.704G>A 1 non_coding_transcript_exon_variant 1472549 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1453 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 715 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 14 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.708C>T rrs_n.708C>T 1 non_coding_transcript_exon_variant 1472553 1 3 0 3 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 21.6259333410942 1 662.5 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 37.2625869115887 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 3 3) Uncertain significance No change no 1 +Amikacin rrs n.712G>A rrs_n.712G>A 1 non_coding_transcript_exon_variant 1472557 0 0 0 0 2 17 2458 21961 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.999226499226499 0.99876183824676 0.999549344777619 0.105263157894736 0.0130121643717774 0.331376664456765 NA NA NA 0 0 0.195064322969093 NA NA NA NA 1560 1832 False False 1.0511175991959 0.117710938762851 4.4327233739406 0 0 0.00149963904330158 0.999226499226499 0.99876183824676 0.999549344777619 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 14 1110 7759 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.998198893606072 0.996979894201843 0.999014979517878 0.0666666666666666 0.0016864302413527 0.319484566578303 NA NA NA 0 0 0.231635761650116 NA NA NA NA 816 981 False False 0 0 0 0 0 0 0 0.499292149292149 0.011800837259916 3.28797630942069 0 0 0.00331779872508707 0.998198893606072 0.996979894201843 0.999014979517878 67 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.713G>A rrs_n.713G>A 1 non_coding_transcript_exon_variant 1472558 1 0 0 0 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1417 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1111 7769 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 681 981 False False 0 0 0 0 0 0 0 0 0 10.6044836876068 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 11 3) Uncertain significance No change no 1 +Amikacin rrs n.717C>T rrs_n.717C>T 1 non_coding_transcript_exon_variant 1472562 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.721G>A rrs_n.721G>A 1 non_coding_transcript_exon_variant 1472566 1 0 0 0 0 5 2460 21973 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1361 1832 False False 0 0 9.75275991328737 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1111 7769 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 626 981 False False 0 0 0 0 0 0 0 0 0 10.6044836876068 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 160 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.724G>A rrs_n.724G>A 1 non_coding_transcript_exon_variant 1472569 1 0 0 0 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1309 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1111 7769 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 578 981 False False 0 0 0 0 0 0 0 0 0 10.6044836876068 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 11 3) Uncertain significance No change no 1 +Amikacin rrs n.725G>A rrs_n.725G>A 1 non_coding_transcript_exon_variant 1472570 0 0 0 0 1 15 2459 21963 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999317499317499 0.998874568358369 0.999617960830416 0.0625 0.00158111172276588 0.302320738434531 NA NA NA 0 0 0.218019360910534 NA NA NA NA 1512 1832 False False 0.595445302968686 0.0141416389361868 3.87379351595292 0 0 0.00149902964335061 0.999317499317499 0.998874568358369 0.999617960830416 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 12 1110 7761 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.99845619451949 0.997304837007313 0.999202046759043 0.0769230769230769 0.00194562849734675 0.360297435267877 NA NA NA 0 0 0.264648469397051 NA NA NA NA 772 981 False False 0 0 0 0 0 0 0 0.582657657657657 0.0136211353314299 3.94507356448373 0 0 0.00331779872508707 0.99845619451949 0.997304837007313 0.999202046759043 36 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.726G>A rrs_n.726G>A 1 non_coding_transcript_exon_variant 1472571 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1619 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 874 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 1 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.726G>C rrs_n.726G>C 1 non_coding_transcript_exon_variant 1472571 NA 0 0 0 1 22 2459 21956 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.998998998998999 0.998484862369405 0.999372575026909 0.0434782608695652 0.0011001686304415 0.21948660745348 NA NA NA 0 0 0.154372512815574 NA NA NA NA 1620 1832 False True 0.40585603904026 0.00983315633476805 2.51317235882738 0 0 0.00149902964335061 0.998998998998999 0.998484862369405 0.999372575026909 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 1 18 1110 7755 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.997684291779235 0.996342642478027 0.998627005047973 0.0526315789473684 0.00133162880417942 0.260280654195214 NA NA NA 0 0 0.185301968137852 NA NA NA NA 875 981 False True 0 1 1 0 0 0 0 0.388138138138138 0.00931070792618223 2.46329230324942 0 0 0.00331779872508707 0.997684291779235 0.996342642478027 0.998627005047973 233 5) Not assoc w R New NotAwR yes 5 +Amikacin rrs n.727T>C rrs_n.727T>C 1 non_coding_transcript_exon_variant 1472572 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.728C>T rrs_n.728C>T 1 non_coding_transcript_exon_variant 1472573 1 0 0 0 0 5 2460 21973 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1255 1832 False False 0 0 9.75275991328737 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1111 7769 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 528 981 False False 0 0 0 0 0 0 0 0 0 10.6044836876068 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 43 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.72G>C rrs_n.72G>C 1 non_coding_transcript_exon_variant 1471917 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.730C>T rrs_n.730C>T 1 non_coding_transcript_exon_variant 1472575 0 0 0 0 1 1 2459 21977 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.9999544999545 0.999746516336938 0.999998848039248 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1561 1832 False False 8.93737291581943 0.113810496005924 697.318539256027 0 0 0.00149902964335061 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 1110 7772 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.99987134954329 0.999283416286792 0.999996742857744 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 817 981 False False 0 0 0 0 0 0 0 7.0018018018018 0.0891187877143753 547.10724479397 0 0 0.00331779872508707 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.734G>A rrs_n.734G>A 1 non_coding_transcript_exon_variant 1472579 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1349 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 617 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 3 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.734G>C rrs_n.734G>C 1 non_coding_transcript_exon_variant 1472579 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1373 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 98 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.734G>T rrs_n.734G>T 1 non_coding_transcript_exon_variant 1472579 0 0 0 0 2 14 2458 21964 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.999362999362999 0.998931451908832 0.999651703457902 0.125 0.0155136038154138 0.383476236849263 NA NA NA 0 0 0.231635761650116 NA NA NA NA 1592 1832 False False 1.27653144252005 0.14074898208514 5.56220221272253 0 0 0.00149963904330158 0.999362999362999 0.998931451908832 0.999651703457902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 11 1110 7762 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.998584844976199 0.99746931080593 0.99929335470516 0.0833333333333333 0.00210759323186022 0.384796165150944 NA NA NA 0 0 0.284914152918154 NA NA NA NA 848 981 False False 0 0 0 0 0 0 0 0.635708435708435 0.0147590703488201 4.38167898705035 0 0 0.00331779872508707 0.998584844976199 0.99746931080593 0.99929335470516 151 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.735C>A rrs_n.735C>A 1 non_coding_transcript_exon_variant 1472580 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1644 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 899 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.735C>G rrs_n.735C>G 1 non_coding_transcript_exon_variant 1472580 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Amikacin rrs n.735C>T rrs_n.735C>T 1 non_coding_transcript_exon_variant 1472580 1 1 0 1 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 346.534733964433 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 96 3) Uncertain significance No change no 1 +Amikacin rrs n.736A>C rrs_n.736A>C 1 non_coding_transcript_exon_variant 1472581 1 0 0 0 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1444 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1111 7769 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 706 981 False False 0 0 0 0 0 0 0 0 0 10.6044836876068 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 21 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.736A>T rrs_n.736A>T 1 non_coding_transcript_exon_variant 1472581 NA 0 0 0 2 21 2458 21957 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.999044499044499 0.998539784170517 0.999408435614546 0.0869565217391304 0.0107099660378758 0.280379335909411 NA NA NA 0 0 0.161097615219079 NA NA NA NA 1319 1832 False True 0.850749738463326 0.0966495499262663 3.48384411336892 0 0 0.00149963904330158 0.999044499044499 0.998539784170517 0.999408435614546 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 1 17 1110 7756 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.997812942235945 0.99650061054502 0.998725458183247 0.0555555555555555 0.00140555616736942 0.272943599673368 NA NA NA 0 0 0.195064322969093 NA NA NA NA 588 981 False True 0 1 1 0 0 0 0 0.411022787493375 0.00982940719196256 2.62850943438846 0 0 0.00331779872508707 0.997812942235945 0.99650061054502 0.998725458183247 217 5) Not assoc w R UP from Uncertain to NotAwR yes 4 +Amikacin rrs n.737G>A rrs_n.737G>A 1 non_coding_transcript_exon_variant 1472582 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1524 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 783 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 4 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.738T>A rrs_n.738T>A 1 non_coding_transcript_exon_variant 1472583 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1362 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 627 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.739A>T rrs_n.739A>T 1 non_coding_transcript_exon_variant 1472584 1 0 0 0 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1418 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1111 7769 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 682 981 False False 0 0 0 0 0 0 0 0 0 10.6044836876068 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 22 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.73A>T rrs_n.73A>T 1 non_coding_transcript_exon_variant 1471918 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1549 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 806 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.746G>A rrs_n.746G>A 1 non_coding_transcript_exon_variant 1472591 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1573 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 828 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 6 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.-74delG rrs_n.-74delG 1 upstream_gene_variant 1471771 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1312 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 580 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 10 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.-74G>A rrs_n.-74G>A 1 upstream_gene_variant 1471772 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.751G>T rrs_n.751G>T 1 non_coding_transcript_exon_variant 1472596 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1574 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 829 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 29 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.752G>A rrs_n.752G>A 1 non_coding_transcript_exon_variant 1472597 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1282 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 552 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 6 3) Uncertain significance No change no 1 +Amikacin rrs n.753A>C rrs_n.753A>C 1 non_coding_transcript_exon_variant 1472598 0 0 0 0 2 19 2458 21959 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.999135499135499 0.99865030256088 0.999479436294878 0.0952380952380952 0.0117493178844458 0.303774406913924 NA NA NA 0 0 0.176466911806965 NA NA NA NA 1431 1832 False False 0.940387991948953 0.106150439671543 3.90169428265347 0 0 0.00149963904330158 0.999135499135499 0.99865030256088 0.999479436294878 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 15 1110 7758 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.998070243149363 0.996819153789367 0.998919540064859 0.0625 0.00158111172276588 0.302320738434531 NA NA NA 0 0 0.218019360910534 NA NA NA NA 693 981 False False 0 0 0 0 0 0 0 0.465945945945945 0.0110614822652538 3.03441935752574 0 0 0.00331779872508707 0.998070243149363 0.996819153789367 0.998919540064859 216 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.753A>T rrs_n.753A>T 1 non_coding_transcript_exon_variant 1472598 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1445 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 707 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 33 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.754G>A rrs_n.754G>A 1 non_coding_transcript_exon_variant 1472599 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1513 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 773 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.754G>T rrs_n.754G>T 1 non_coding_transcript_exon_variant 1472599 1 0 0 0 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1296 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 565 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 175 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.762G>A rrs_n.762G>A 1 non_coding_transcript_exon_variant 1472607 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1283 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 553 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 13 3) Uncertain significance No change no 1 +Amikacin rrs n.763T>C rrs_n.763T>C 1 non_coding_transcript_exon_variant 1472608 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.767G>T rrs_n.767G>T 1 non_coding_transcript_exon_variant 1472612 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1350 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 618 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 6 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.769G>T rrs_n.769G>T 1 non_coding_transcript_exon_variant 1472614 1 0 0 0 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1607 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 864 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 30 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.771G>A rrs_n.771G>A 1 non_coding_transcript_exon_variant 1472616 0 0 0 0 1 17 2459 21961 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999226499226499 0.99876183824676 0.999549344777619 0.0555555555555555 0.00140555616736942 0.272943599673368 NA NA NA 0 0 0.195064322969093 NA NA NA NA 1629 1832 False False 0.525345070927923 0.0125684463564045 3.3556642410537 0 0 0.00149902964335061 0.999226499226499 0.99876183824676 0.999549344777619 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 14 1110 7759 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.998198893606072 0.996979894201843 0.999014979517878 0.0666666666666666 0.0016864302413527 0.319484566578303 NA NA NA 0 0 0.231635761650116 NA NA NA NA 884 981 False False 0 0 0 0 0 0 0 0.499292149292149 0.011800837259916 3.28797630942069 0 0 0.00331779872508707 0.998198893606072 0.996979894201843 0.999014979517878 210 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.78_80delTCTinsCC rrs_n.78_80delTCTinsCC 1 non_coding_transcript_exon_variant 1471923 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1241 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 514 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.78T>C rrs_n.78T>C 1 non_coding_transcript_exon_variant 1471923 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1593 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 849 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 5 3) Uncertain significance No change no 1 +Amikacin rrs n.-78T>C rrs_n.-78T>C 1 upstream_gene_variant 1471768 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin rrs n.799C>A rrs_n.799C>A 1 non_coding_transcript_exon_variant 1472644 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1242 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 515 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 9 3) Uncertain significance No change no 1 +Amikacin rrs n.799C>T rrs_n.799C>T 1 non_coding_transcript_exon_variant 1472644 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1630 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 885 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 13 3) Uncertain significance No change no 1 +Amikacin rrs n.-79T>C rrs_n.-79T>C 1 upstream_gene_variant 1471767 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.-7G>A rrs_n.-7G>A 1 upstream_gene_variant 1471839 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1457 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.808C>T rrs_n.808C>T 1 non_coding_transcript_exon_variant 1472653 1 3 1 2 1 2 2459 21976 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999908999909 0.999671315452743 0.999988979276808 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 4.46848312322082 0.0757100934104112 86.0774363890598 0.272619661115539 84 1832 False False 4.46848312322082 0.0757100934104112 86.0774363890598 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Amikacin rrs n.80T>C rrs_n.80T>C 1 non_coding_transcript_exon_variant 1471925 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1454 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 716 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance No change no 1 +Amikacin rrs n.-81_-80insG rrs_n.-81_-80insG 1 upstream_gene_variant 1471765 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin rrs n.810G>A rrs_n.810G>A 1 non_coding_transcript_exon_variant 1472655 1 0 0 0 0 8 2460 21970 0 0 0.00149842073847528 0.999635999635999 0.999282900840091 0.999842837798826 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1297 1832 False False 0 0 5.2353912865109 0 0 0.00149842073847528 0.999635999635999 0.999282900840091 0.999842837798826 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 1111 7768 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 566 981 False False 0 0 0 0 0 0 0 0 0 7.63947436138835 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 40 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.810G>T rrs_n.810G>T 1 non_coding_transcript_exon_variant 1472655 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1631 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 886 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 42 3) Uncertain significance No change no 1 +Amikacin rrs n.813G>A rrs_n.813G>A 1 non_coding_transcript_exon_variant 1472658 1 0 0 0 0 7 2460 21971 0 0 0.00149842073847528 0.999681499681499 0.999343878425726 0.999871937071415 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1632 1832 False False 0 0 6.20059597931892 0 0 0.00149842073847528 0.999681499681499 0.999343878425726 0.999871937071415 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1111 7769 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 887 981 False False 0 0 0 0 0 0 0 0 0 10.6044836876068 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 33 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.814G>A rrs_n.814G>A 1 non_coding_transcript_exon_variant 1472659 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1404 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 668 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.815T>C rrs_n.815T>C 1 non_coding_transcript_exon_variant 1472660 1 0 0 0 0 5 2460 21973 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1432 1832 False False 0 0 9.75275991328737 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 1111 7768 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 694 981 False False 0 0 0 0 0 0 0 0 0 7.63947436138835 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 39 3) Uncertain significance No change no 1 +Amikacin rrs n.816A>G rrs_n.816A>G 1 non_coding_transcript_exon_variant 1472661 NA 0 0 0 0 8 2460 21970 0 0 0.00149842073847528 0.999635999635999 0.999282900840091 0.999842837798826 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1562 1832 False True 0 0 5.2353912865109 0 0 0.00149842073847528 0.999635999635999 0.999282900840091 0.999842837798826 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 5 1111 7768 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 818 981 False True 1 0 1 0 0 0 0 0 0 7.63947436138835 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 38 5) Not assoc w R New NotAwR yes 5 +Amikacin rrs n.81C>T rrs_n.81C>T 1 non_coding_transcript_exon_variant 1471926 0 0 0 0 1 1 2459 21977 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.9999544999545 0.999746516336938 0.999998848039248 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1273 1832 False False 8.93737291581943 0.113810496005924 697.318539256027 0 0 0.00149902964335061 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 544 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 2 3) Uncertain significance No change no 1 +Amikacin rrs n.820G>A rrs_n.820G>A 1 non_coding_transcript_exon_variant 1472665 1 0 0 0 0 5 2460 21973 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1501 1832 False False 0 0 9.75275991328737 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 762 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 5 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.824_825insTAGA rrs_n.824_825insTAGA 1 non_coding_transcript_exon_variant 1472669 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1472 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 734 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.824_825insTAGG rrs_n.824_825insTAGG 1 non_coding_transcript_exon_variant 1472669 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1446 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 708 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 3 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.828T>A rrs_n.828T>A 1 non_coding_transcript_exon_variant 1472673 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1433 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 695 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 3 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.828T>C rrs_n.828T>C 1 non_coding_transcript_exon_variant 1472673 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1243 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 516 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.829T>A rrs_n.829T>A 1 non_coding_transcript_exon_variant 1472674 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1455 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 717 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.-82C>T rrs_n.-82C>T 1 upstream_gene_variant 1471764 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.830T>A rrs_n.830T>A 1 non_coding_transcript_exon_variant 1472675 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1434 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 696 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin rrs n.830T>C rrs_n.830T>C 1 non_coding_transcript_exon_variant 1472675 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1310 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 579 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 10 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.830T>G rrs_n.830T>G 1 non_coding_transcript_exon_variant 1472675 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1594 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 850 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.832C>A rrs_n.832C>A 1 non_coding_transcript_exon_variant 1472677 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1575 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 830 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 7 3) Uncertain significance No change no 1 +Amikacin rrs n.833_834delTTinsGCC rrs_n.833_834delTTinsGCC 1 non_coding_transcript_exon_variant 1472678 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1563 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 819 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 3 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.833T>G rrs_n.833T>G 1 non_coding_transcript_exon_variant 1472678 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1621 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 876 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.834T>C rrs_n.834T>C 1 non_coding_transcript_exon_variant 1472679 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1502 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 763 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.836C>G rrs_n.836C>G 1 non_coding_transcript_exon_variant 1472681 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.837T>A rrs_n.837T>A 1 non_coding_transcript_exon_variant 1472682 1 0 0 0 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1384 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1111 7769 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 648 981 False False 0 0 0 0 0 0 0 0 0 10.6044836876068 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 10 3) Uncertain significance No change no 1 +Amikacin rrs n.837T>G rrs_n.837T>G 1 non_coding_transcript_exon_variant 1472682 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance No change no 1 +Amikacin rrs n.838T>C rrs_n.838T>C 1 non_coding_transcript_exon_variant 1472683 1 0 0 0 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1435 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1111 7769 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 697 981 False False 0 0 0 0 0 0 0 0 0 10.6044836876068 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 10 3) Uncertain significance No change no 1 +Amikacin rrs n.839_845delGGGATCCinsA rrs_n.839_845delGGGATCCinsA 1 non_coding_transcript_exon_variant 1472684 1 0 0 0 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1456 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 718 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 4 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.839_845delGGGATCCinsTA rrs_n.839_845delGGGATCCinsTA 1 non_coding_transcript_exon_variant 1472684 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1298 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 567 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.840G>T rrs_n.840G>T 1 non_coding_transcript_exon_variant 1472685 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1473 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 735 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 NA 3) Uncertain significance No change no 1 +Amikacin rrs n.841G>T rrs_n.841G>T 1 non_coding_transcript_exon_variant 1472686 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1514 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 774 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 1 3) Uncertain significance No change no 1 +Amikacin rrs n.842A>G rrs_n.842A>G 1 non_coding_transcript_exon_variant 1472687 1 1 0 1 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 346.519051274799 1 662.5 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 831 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 2 3) Uncertain significance No change no 1 +Amikacin rrs n.842A>T rrs_n.842A>T 1 non_coding_transcript_exon_variant 1472687 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1564 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 820 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 10 3) Uncertain significance No change no 1 +Amikacin rrs n.847T>C rrs_n.847T>C 1 non_coding_transcript_exon_variant 1472692 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 2 3) Uncertain significance No change no 1 +Amikacin rrs n.84C>T rrs_n.84C>T 1 non_coding_transcript_exon_variant 1471929 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.850C>T rrs_n.850C>T 1 non_coding_transcript_exon_variant 1472695 1 0 0 0 0 7 2460 21971 0 0 0.00149842073847528 0.999681499681499 0.999343878425726 0.999871937071415 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1595 1832 False False 0 0 6.20059597931892 0 0 0.00149842073847528 0.999681499681499 0.999343878425726 0.999871937071415 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1111 7769 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 851 981 False False 0 0 0 0 0 0 0 0 0 10.6044836876068 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 5 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.852T>C rrs_n.852T>C 1 non_coding_transcript_exon_variant 1472697 NA 0 0 0 0 10 2460 21968 0 0 0.00149842073847528 0.999544999544999 0.999163397681526 0.999781788721324 0 0 0.30849710781876 NA NA NA 0 0 0.30849710781876 NA NA NA NA 1645 1832 False True 0 0 3.98680916993403 0 0 0.00149842073847528 0.999544999544999 0.999163397681526 0.999781788721324 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 7 1111 7766 0 0 0.00331481736263177 0.999099446803036 0.998145402056424 0.999637856686565 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 900 981 False True 1 0 1 0 0 0 0 0 0 4.85661817639599 0 0 0.00331481736263177 0.999099446803036 0.998145402056424 0.999637856686565 89 5) Not assoc w R New NotAwR yes 5 +Amikacin rrs n.852T>G rrs_n.852T>G 1 non_coding_transcript_exon_variant 1472697 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1385 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 649 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.856T>A rrs_n.856T>A 1 non_coding_transcript_exon_variant 1472701 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1419 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.859C>T rrs_n.859C>T 1 non_coding_transcript_exon_variant 1472704 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.861C>T rrs_n.861C>T 1 non_coding_transcript_exon_variant 1472706 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Amikacin rrs n.868T>C rrs_n.868T>C 1 non_coding_transcript_exon_variant 1472713 NA 0 0 0 2 22 2458 21956 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.998998998998999 0.998484862369405 0.999372575026909 0.0833333333333333 0.0102563412812501 0.269972801557603 NA NA NA 0 0 0.154372512815574 NA NA NA NA 1363 1832 False True 0.812042310821806 0.0925091311446035 3.30662898238902 0 0 0.00149963904330158 0.998998998998999 0.998484862369405 0.999372575026909 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 1 16 1110 7757 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.997941592692654 0.996659422164099 0.998822998929686 0.0588235294117647 0.00148817439126663 0.28688939666722 NA NA NA 0 0 0.205907214207822 NA NA NA NA 628 981 False True 1 1 1 0 0 0 0 0.436768018018018 0.0104091785493508 2.81700277572341 0 0 0.00331779872508707 0.997941592692654 0.996659422164099 0.998822998929686 341 5) Not assoc w R New NotAwR yes 5 +Amikacin rrs n.869A>G rrs_n.869A>G 1 non_coding_transcript_exon_variant 1472714 1 0 0 0 0 6 2460 21972 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1585 1832 False False 0 0 7.5904311186467 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 1111 7767 0 0 0.00331481736263177 0.999228097259745 0.998320655545558 0.999716674296114 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 842 981 False False 0 0 0 0 0 0 0 0 0 5.94541565066903 0 0 0.00331481736263177 0.999228097259745 0.998320655545558 0.999716674296114 117 3) Uncertain significance No change no 1 +Amikacin rrs n.86G>A rrs_n.86G>A 1 non_coding_transcript_exon_variant 1471931 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1256 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.87_89delAGAinsGG rrs_n.87_89delAGAinsGG 1 non_coding_transcript_exon_variant 1471932 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1489 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 749 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.871C>T rrs_n.871C>T 1 non_coding_transcript_exon_variant 1472716 NA 0 0 0 2 21 2458 21957 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.999044499044499 0.998539784170517 0.999408435614546 0.0869565217391304 0.0107099660378758 0.280379335909411 NA NA NA 0 0 0.161097615219079 NA NA NA NA 1334 1832 False True 0.850749738463326 0.0966495499262663 3.48384411336892 0 0 0.00149963904330158 0.999044499044499 0.998539784170517 0.999408435614546 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 1 15 1110 7758 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.998070243149363 0.996819153789367 0.998919540064859 0.0625 0.00158111172276588 0.302320738434531 NA NA NA 0 0 0.218019360910534 NA NA NA NA 602 981 False True 0 1 1 0 0 0 0 0.465945945945945 0.0110614822652538 3.03441935752574 0 0 0.00331779872508707 0.998070243149363 0.996819153789367 0.998919540064859 335 5) Not assoc w R New NotAwR yes 5 +Amikacin rrs n.876C>A rrs_n.876C>A 1 non_coding_transcript_exon_variant 1472721 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.878G>A rrs_n.878G>A 1 non_coding_transcript_exon_variant 1472723 1 49 1 48 2 55 2458 21923 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.997497497497497 0.996743878846489 0.998114233222622 0.0350877192982456 0.00427789494053177 0.121070663196201 0.0204081632653061 0.000516556497593286 0.108541763968406 0.0178571428571428 0.000452001530520825 0.0955259026323396 0.185813330621101 0.00461118162533979 1.08701905814569 0.0579828093843225 25 1832 False False 0.324328722538649 0.0382978395140653 1.22996262356997 0.000406669377795852 1.02959242167344e-05 0.0022637116293895 0.997497497497497 0.996743878846489 0.998114233222622 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 7 1111 7766 0 0 0.00331481736263177 0.999099446803036 0.998145402056424 0.999637856686565 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 5.94465031655427 1 267 981 False False 0 0 0 0 0 0 0 0 0 4.85661817639599 0 0 0.00331481736263177 0.999099446803036 0.998145402056424 0.999637856686565 32 3) Uncertain significance No change no 1 +Amikacin rrs n.887G>A rrs_n.887G>A 1 non_coding_transcript_exon_variant 1472732 1 3 0 3 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 21.6259333410942 1 662.5 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.888G>A rrs_n.888G>A 1 non_coding_transcript_exon_variant 1472733 1 0 0 0 0 12 2460 21966 0 0 0.00149842073847528 0.999453999453999 0.999046441372309 0.999717842739244 0 0 0.264648469397051 NA NA NA 0 0 0.264648469397051 NA NA NA NA 1274 1832 False False 0 0 3.21614145803178 0 0 0.00149842073847528 0.999453999453999 0.999046441372309 0.999717842739244 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 9 1111 7764 0 0 0.00331481736263177 0.998842145889618 0.997803175208698 0.999470423012169 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 545 981 False False 0 0 0 0 0 0 0 0 0 3.54586915871032 0 0 0.00331481736263177 0.998842145889618 0.997803175208698 0.999470423012169 341 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.888G>C rrs_n.888G>C 1 non_coding_transcript_exon_variant 1472733 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1535 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 792 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 26 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.889C>T rrs_n.889C>T 1 non_coding_transcript_exon_variant 1472734 0 0 0 0 1 16 2459 21962 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999271999271999 0.998818040931792 0.999583829243268 0.0588235294117647 0.00148817439126663 0.28688939666722 NA NA NA 0 0 0.205907214207822 NA NA NA NA 1474 1832 False True 0.558204554697031 0.013308736221939 3.59638627394134 0 0 0.00149902964335061 0.999271999271999 0.998818040931792 0.999583829243268 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 11 1111 7762 0 0 0.00331481736263177 0.998584844976199 0.99746931080593 0.99929335470516 0 0 0.284914152918154 NA NA NA 0 0 0.284914152918154 NA NA NA NA 736 981 False True 0 1 1 0 0 0 0 0 0 2.78806716438789 0 0 0.00331481736263177 0.998584844976199 0.99746931080593 0.99929335470516 45 5) Not assoc w R New NotAwR yes 5 +Amikacin rrs n.891G>A rrs_n.891G>A 1 non_coding_transcript_exon_variant 1472736 1 5 0 5 0 5 2460 21973 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 9.75275991328737 1 662.5 1832 False False 0 0 9.75275991328737 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 16.9345443329059 1 267 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 11 3) Uncertain significance No change no 1 +Amikacin rrs n.896G>A rrs_n.896G>A 1 non_coding_transcript_exon_variant 1472741 0 0 0 0 1 16 2459 21962 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999271999271999 0.998818040931792 0.999583829243268 0.0588235294117647 0.00148817439126663 0.28688939666722 NA NA NA 0 0 0.205907214207822 NA NA NA NA 1284 1832 False True 0.558204554697031 0.013308736221939 3.59638627394134 0 0 0.00149902964335061 0.999271999271999 0.998818040931792 0.999583829243268 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 11 1111 7762 0 0 0.00331481736263177 0.998584844976199 0.99746931080593 0.99929335470516 0 0 0.284914152918154 NA NA NA 0 0 0.284914152918154 NA NA NA NA 554 981 False True 0 1 1 0 0 0 0 0 0 2.78806716438789 0 0 0.00331481736263177 0.998584844976199 0.99746931080593 0.99929335470516 44 5) Not assoc w R New NotAwR yes 5 +Amikacin rrs n.897C>G rrs_n.897C>G 1 non_coding_transcript_exon_variant 1472742 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1646 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 901 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 26 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.897C>T rrs_n.897C>T 1 non_coding_transcript_exon_variant 1472742 1 0 0 0 0 18 2460 21960 0 0 0.00149842073847528 0.999180999180999 0.998705933279372 0.999514538264563 0 0 0.185301968137852 NA NA NA 0 0 0.185301968137852 NA NA NA NA 1386 1832 False False 0 0 2.03197230182158 0 0 0.00149842073847528 0.999180999180999 0.998705933279372 0.999514538264563 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 11 1111 7762 0 0 0.00331481736263177 0.998584844976199 0.99746931080593 0.99929335470516 0 0 0.284914152918154 NA NA NA 0 0 0.284914152918154 NA NA NA NA 650 981 False False 0 0 0 0 0 0 0 0 0 2.78806716438789 0 0 0.00331481736263177 0.998584844976199 0.99746931080593 0.99929335470516 384 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.899A>G rrs_n.899A>G 1 non_coding_transcript_exon_variant 1472744 NA 0 0 0 2 31 2458 21947 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.998589498589498 0.997998498131125 0.999041437774243 0.0606060606060606 0.0074258377422598 0.202264312526355 NA NA NA 0 0 0.11218874692237 NA NA NA NA 1320 1832 False True 0.576051864878343 0.0667596981182228 2.2662733353732 0 0 0.00149963904330158 0.998589498589498 0.997998498131125 0.999041437774243 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 1 22 1110 7751 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.997169689952399 0.995717994167339 0.998225435954744 0.0434782608695652 0.0011001686304415 0.21948660745348 NA NA NA 0 0 0.154372512815574 NA NA NA NA 589 981 False True 0 1 1 0 0 0 0 0.317403767403767 0.00768722307113518 1.96773914587886 0 0 0.00331779872508707 0.997169689952399 0.995717994167339 0.998225435954744 412 5) Not assoc w R New NotAwR yes 5 +Amikacin rrs n.89A>G rrs_n.89A>G 1 non_coding_transcript_exon_variant 1471934 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 5 3) Uncertain significance No change no 1 +Amikacin rrs n.-89T>C rrs_n.-89T>C 1 upstream_gene_variant 1471757 1 1 1 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.22908065008664 Inf 0.100662902037809 42.5 1832 False False Inf 0.22908065008664 Inf 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.905C>A rrs_n.905C>A 1 non_coding_transcript_exon_variant 1472750 1 9 0 9 1 9 2459 21969 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999590499590499 0.999222783640785 0.999812733785825 0.1 0.00252857854446178 0.445016117028195 0 0 0.336267116879942 0 0 0.336267116879942 0 0 4.52927702182454 0.612240985626234 121 1832 False False 0.992679951199674 0.0226387633018841 7.16949857929758 0 0 0.00149902964335061 0.999590499590499 0.999222783640785 0.999812733785825 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 5 3) Uncertain significance No change no 1 +Amikacin rrs n.905C>G rrs_n.905C>G 1 non_coding_transcript_exon_variant 1472750 1 6 1 5 1 6 2459 21972 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999726999726999 0.999405888764937 0.999899807333004 0.142857142857142 0.00361029686190058 0.578723197043195 0.166666666666666 0.00421074451448947 0.641234578997674 0.142857142857142 0.00361029686190058 0.578723197043195 1.78706791378609 0.0377683249065601 15.9785793896278 0.470954199105129 106 1832 False False 1.48922326148841 0.0323630859858146 12.2827873722144 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999726999726999 0.999405888764937 0.999899807333004 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 16.9345443329059 1 267 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 9 3) Uncertain significance No change no 1 +Amikacin rrs n.905C>T rrs_n.905C>T 1 non_coding_transcript_exon_variant 1472750 1 1 0 1 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 346.534733964433 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 651 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 3 3) Uncertain significance No change no 1 +Amikacin rrs n.906A>G rrs_n.906A>G 1 non_coding_transcript_exon_variant 1472751 1 65 0 65 9 80 2451 21898 0.00365853658536585 0.00167423871507945 0.00693363251119005 0.996359996359996 0.995471718213931 0.997112680245709 0.101123595505617 0.0472928584379 0.183302053161412 0 0 0.0551716343188133 0 0 0.0450640350676923 0 0 0.522140997332116 0.00157271869029318 10 1832 False True 1.00511015911872 0.442937777118798 2.00858314424815 0 0 0.00150391875593933 0.996359996359996 0.995471718213931 0.997112680245709 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 29 0 29 0 34 1111 7739 0 0 0.00331481736263177 0.995625884471889 0.993892926927706 0.996968952841175 0 0 0.102817924259012 0 0 0.119444869069502 0 0 0.102817924259012 0 0 0.946632116518935 0.0431071842021248 16 981 False True 1 1 1 0 0 0 0 0 0 0.799785871619012 0 0 0.00331481736263177 0.995625884471889 0.993892926927706 0.996968952841175 57 5) Not assoc w R UP from Uncertain to NotAwR yes 4 +Amikacin rrs n.907_908dupAA rrs_n.907_908dupAA 1 non_coding_transcript_exon_variant 1472750 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.907A>C rrs_n.907A>C 1 non_coding_transcript_exon_variant 1472752 1 1 0 1 1 1 2459 21977 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.9999544999545 0.999746516336938 0.999998848039248 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 346.690584657338 1 662.5 1832 False False 8.93737291581943 0.113810496005924 697.318539256027 0 0 0.00149902964335061 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Amikacin rrs n.907A>T rrs_n.907A>T 1 non_coding_transcript_exon_variant 1472752 1 5 0 5 0 5 2460 21973 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 9.75275991328737 1 662.5 1832 False False 0 0 9.75275991328737 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 16.9345443329059 1 267 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 3 3) Uncertain significance No change no 1 +Amikacin rrs n.908_909insT rrs_n.908_909insT 1 non_coding_transcript_exon_variant 1472753 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance No change no 1 +Amikacin rrs n.908A>C rrs_n.908A>C 1 non_coding_transcript_exon_variant 1472753 1 25 1 24 1 25 2459 21953 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.998862498862498 0.99832127875239 0.999263738201867 0.0384615384615384 0.00097328789333503 0.196369646762539 0.04 0.00101219969931084 0.203516913922414 0.0384615384615384 0.00097328789333503 0.196369646762539 0.371983868781347 0.00904514855040883 2.2833204608077 0.507567968345909 108 1832 False False 0.357104514030093 0.00869722506568978 2.18353863379849 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.998862498862498 0.99832127875239 0.999263738201867 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 7 1111 7766 0 0 0.00331481736263177 0.999099446803036 0.998145402056424 0.999637856686565 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 4.85661817639599 0.607108338811034 47 981 False False 0 0 0 0 0 0 0 0 0 4.85661817639599 0 0 0.00331481736263177 0.999099446803036 0.998145402056424 0.999637856686565 16 3) Uncertain significance No change no 1 +Amikacin rrs n.908A>G rrs_n.908A>G 1 non_coding_transcript_exon_variant 1472753 1 4 0 4 0 5 2460 21973 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 13.5421472279808 1 662.5 1832 False False 0 0 9.75275991328737 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 37.2577954991549 1 267 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 3 3) Uncertain significance No change no 1 +Amikacin rrs n.908A>T rrs_n.908A>T 1 non_coding_transcript_exon_variant 1472753 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.909G>T rrs_n.909G>T 1 non_coding_transcript_exon_variant 1472754 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1565 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.910G>A rrs_n.910G>A 1 non_coding_transcript_exon_variant 1472755 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1596 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 852 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 20 3) Uncertain significance No change no 1 +Amikacin rrs n.911A>C rrs_n.911A>C 1 non_coding_transcript_exon_variant 1472756 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.-91C>A rrs_n.-91C>A 1 upstream_gene_variant 1471755 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.-91C>T rrs_n.-91C>T 1 upstream_gene_variant 1471755 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1633 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 888 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 1 3) Uncertain significance No change no 1 +Amikacin rrs n.922G>A rrs_n.922G>A 1 non_coding_transcript_exon_variant 1472767 1 0 0 0 0 12 2460 21966 0 0 0.00149842073847528 0.999453999453999 0.999046441372309 0.999717842739244 0 0 0.264648469397051 NA NA NA 0 0 0.264648469397051 NA NA NA NA 1576 1832 False False 0 0 3.21614145803178 0 0 0.00149842073847528 0.999453999453999 0.999046441372309 0.999717842739244 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 8 1111 7765 0 0 0.00331481736263177 0.998970796346327 0.997973071099689 0.99955556151365 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 832 981 False False 0 0 0 0 0 0 0 0 0 4.10060236216416 0 0 0.00331481736263177 0.998970796346327 0.997973071099689 0.99955556151365 68 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.924C>T rrs_n.924C>T 1 non_coding_transcript_exon_variant 1472769 0 0 0 0 2 0 2458 21978 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 1 0.99983216990204 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1299 1832 False False Inf 1.67834993427241 Inf 0 0 0.00149963904330158 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 1109 7773 0.0018001800180018 0.000218084550259369 0.00648759665094944 1 0.999525536566873 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 568 981 False False 0 0 0 0 0 0 0 Inf 1.31458832505494 Inf 0 0 0.00332078545526824 1 0.999525536566873 1 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.-92T>G rrs_n.-92T>G 1 upstream_gene_variant 1471754 1 0 0 0 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1275 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Amikacin rrs n.93_94insG rrs_n.93_94insG 1 non_coding_transcript_exon_variant 1471938 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.934G>A rrs_n.934G>A 1 non_coding_transcript_exon_variant 1472779 1 0 0 0 0 6 2460 21972 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1490 1832 False False 0 0 7.5904311186467 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 1111 7768 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 750 981 False False 0 0 0 0 0 0 0 0 0 7.63947436138835 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 10 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.935G>A rrs_n.935G>A 1 non_coding_transcript_exon_variant 1472780 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Amikacin rrs n.936C>T rrs_n.936C>T 1 non_coding_transcript_exon_variant 1472781 NA 0 0 0 2 42 2458 21936 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.998088998088998 0.997417748854129 0.998622381482239 0.0454545454545454 0.00555295199537049 0.154731577658989 NA NA NA 0 0 0.0840838549403552 NA NA NA NA 1608 1832 False True 0.424968034406602 0.0498079115547985 1.63546289528986 0 0 0.00149963904330158 0.998088998088998 0.997417748854129 0.998622381482239 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 1 27 1110 7746 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.996526437668853 0.994950143627592 0.997709690585787 0.0357142857142857 0.000903798755658059 0.183477597544623 NA NA NA 0 0 0.127702867615432 NA NA NA NA 865 981 False True 0 1 1 0 0 0 0 0.258458458458458 0.00631048679926752 1.5714176268349 0 0 0.00331779872508707 0.996526437668853 0.994950143627592 0.997709690585787 496 5) Not assoc w R New NotAwR yes 5 +Amikacin rrs n.-93C>T rrs_n.-93C>T 1 upstream_gene_variant 1471753 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1526 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Amikacin rrs n.93dupT rrs_n.93dupT 1 non_coding_transcript_exon_variant 1471937 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.93T>A rrs_n.93T>A 1 non_coding_transcript_exon_variant 1471938 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1436 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 698 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.93T>G rrs_n.93T>G 1 non_coding_transcript_exon_variant 1471938 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.941C>T rrs_n.941C>T 1 non_coding_transcript_exon_variant 1472786 1 0 0 0 0 5 2460 21973 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1550 1832 False False 0 0 9.75275991328737 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1111 7769 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 807 981 False False 0 0 0 0 0 0 0 0 0 10.6044836876068 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 7 3) Uncertain significance No change no 1 +Amikacin rrs n.945T>C rrs_n.945T>C 1 non_coding_transcript_exon_variant 1472790 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1503 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 764 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 84 3) Uncertain significance No change no 1 +Amikacin rrs n.946G>C rrs_n.946G>C 1 non_coding_transcript_exon_variant 1472791 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.948A>C rrs_n.948A>C 1 non_coding_transcript_exon_variant 1472793 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1447 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 709 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 1 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.948A>T rrs_n.948A>T 1 non_coding_transcript_exon_variant 1472793 0 0 0 0 2 40 2458 21938 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.998179998179998 0.997522490030905 0.998699455493482 0.0476190476190476 0.00581982483550999 0.161641959691653 NA NA NA 0 0 0.0880973028788023 NA NA NA NA 1244 1832 False True 0.446257119609438 0.0522205163457848 1.7226865186343 0 0 0.00149963904330158 0.998179998179998 0.997522490030905 0.998699455493482 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 1 26 1110 7747 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.996655088125562 0.995102743563572 0.997813864490847 0.037037037037037 0.000937257091944708 0.189705617413044 NA NA NA 0 0 0.132274604497754 NA NA NA NA 517 981 False True 1 1 1 0 0 0 0 0.268433818433818 0.00654502028374561 1.63750267764139 0 0 0.00331779872508707 0.996655088125562 0.995102743563572 0.997813864490847 486 5) Not assoc w R New NotAwR yes 5 +Amikacin rrs n.958T>A rrs_n.958T>A 1 non_coding_transcript_exon_variant 1472803 0 0 0 0 2 35 2458 21943 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.998407498407498 0.997785905018943 0.998890521362752 0.054054054054054 0.00661457041152882 0.181949118377749 NA NA NA 0 0 0.100032435572105 NA NA NA NA 1300 1832 False True 0.510124375217947 0.0594123905132907 1.98762291507056 0 0 0.00149963904330158 0.998407498407498 0.997785905018943 0.998890521362752 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 1 24 1110 7749 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.996912389038981 0.995409340961643 0.998020738273106 0.04 0.00101219969931084 0.203516913922414 NA NA NA 0 0 0.142473597722525 NA NA NA NA 569 981 False True 1 1 1 0 0 0 0 0.290878378378378 0.00707040759406696 1.78755442492584 0 0 0.00331779872508707 0.996912389038981 0.995409340961643 0.998020738273106 459 5) Not assoc w R New NotAwR yes 5 +Amikacin rrs n.958T>C rrs_n.958T>C 1 non_coding_transcript_exon_variant 1472803 1 0 0 0 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1257 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 529 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 3 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.972C>T rrs_n.972C>T 1 non_coding_transcript_exon_variant 1472817 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.979T>A rrs_n.979T>A 1 non_coding_transcript_exon_variant 1472824 NA 0 0 0 0 5 2460 21973 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1335 1832 False True 0 0 9.75275991328737 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 603 981 False True 1 0 1 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 24 5) Not assoc w R New NotAwR yes 5 +Amikacin rrs n.980G>A rrs_n.980G>A 1 non_coding_transcript_exon_variant 1472825 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1551 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 808 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 24 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.981G>A rrs_n.981G>A 1 non_coding_transcript_exon_variant 1472826 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1515 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.982G>T rrs_n.982G>T 1 non_coding_transcript_exon_variant 1472827 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1258 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 530 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.983T>C rrs_n.983T>C 1 non_coding_transcript_exon_variant 1472828 1 1 0 1 0 6 2460 21972 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 0 0 0.4592581264399 0 0 0.975 0 0 0.4592581264399 0 0 346.472003159528 1 165 1832 False True 0 0 7.5904311186467 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 518 981 False True 1 1 1 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 37 5) Not assoc w R New NotAwR yes 5 +Amikacin rrs n.98T>C rrs_n.98T>C 1 non_coding_transcript_exon_variant 1471943 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1577 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 833 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.991_992delGCinsCCTTTG rrs_n.991_992delGCinsCCTTTG 1 non_coding_transcript_exon_variant 1472836 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1311 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.991_996delGCACAGinsCCTCT rrs_n.991_996delGCACAGinsCCTCT 1 non_coding_transcript_exon_variant 1472836 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1491 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 751 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.995A>C rrs_n.995A>C 1 non_coding_transcript_exon_variant 1472840 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1552 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 809 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.996_1002delGGACGCGinsAC rrs_n.996_1002delGGACGCGinsAC 1 non_coding_transcript_exon_variant 1472841 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1405 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.996_1003delGGACGCGTinsACC rrs_n.996_1003delGGACGCGTinsACC 1 non_coding_transcript_exon_variant 1472841 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1647 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.999C>A rrs_n.999C>A 1 non_coding_transcript_exon_variant 1472844 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1609 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 866 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin rrs n.9G>A rrs_n.9G>A 1 non_coding_transcript_exon_variant 1471854 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin rrs n.-9G>C rrs_n.-9G>C 1 upstream_gene_variant 1471837 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c c.1002C>T Rv2477c_c.1002C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.1030T>C Rv2477c_c.1030T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.1068C>T Rv2477c_c.1068C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 3 2458 21975 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.9998634998635 0.999601141012814 0.999971849505602 0.4 0.0527449505263169 0.853367200365326 NA NA NA NA NA NA NA NA NA NA NA NA False False 5.96013018714402 0.497500621694734 52.0542994003282 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.1071G>T Rv2477c_c.1071G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.1086A>G Rv2477c_c.1086A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 21.6259333410942 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 16.9345443329059 NA NA NA NA NA NA 34 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.1101C>T Rv2477c_c.1101C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 21.6259333410942 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 37.2625869115887 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.1104C>T Rv2477c_c.1104C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 13.5427650126618 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 37.2625869115887 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.1116A>G Rv2477c_c.1116A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 17 2457 21961 0.00121951219512195 0.00025156337591866 0.00355975660270706 0.999226499226499 0.99876183824676 0.999549344777619 0.15 0.0320709371854637 0.378926826545313 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.57731810672987 0.295964682533419 5.45915054819239 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 6 1111 7767 0 0 0.00331481736263177 0.999228097259745 0.998320655545558 0.999716674296114 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 5.94541565066903 NA NA NA NA NA NA 126 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.1122C>T Rv2477c_c.1122C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.1152C>A Rv2477c_c.1152C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.1152C>G Rv2477c_c.1152C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.1158G>A Rv2477c_c.1158G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.1164C>T Rv2477c_c.1164C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 21.6259333410942 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 16.9345443329059 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.1176C>T Rv2477c_c.1176C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.1212G>A Rv2477c_c.1212G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 21.6259333410942 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.1221G>A Rv2477c_c.1221G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.1269G>A Rv2477c_c.1269G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.1275C>T Rv2477c_c.1275C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.-12C>A Rv2477c_c.-12C>A 2 upstream_gene_variant 2784054 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1808 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c c.1335C>T Rv2477c_c.1335C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.1401C>T Rv2477c_c.1401C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.1434G>C Rv2477c_c.1434G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.1443G>C Rv2477c_c.1443G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.1497C>T Rv2477c_c.1497C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.1512C>T Rv2477c_c.1512C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.1521G>T Rv2477c_c.1521G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.1542T>C Rv2477c_c.1542T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.1545C>T Rv2477c_c.1545C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 92 2101 2368 19877 0.0373983739837398 0.0302527790459365 0.0456703693274331 0.904404404404404 0.900440633358826 0.908260844931858 0.0419516643866849 0.0339505417166758 0.0512039013088114 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.367562261214093 0.293748636196481 0.455198172289905 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 34 454 1077 7319 0.0306030603060306 0.0212846698502855 0.0425038099288588 0.941592692654058 0.936147214843598 0.946704027524608 0.0696721311475409 0.0487292578487625 0.0960016231767783 NA NA NA NA NA NA NA NA NA NA NA NA False True 1 1 1 0 0 0 0 0.508931237447797 0.346096157416578 0.72663436031004 NA NA NA NA NA NA 3872 5) Not assoc w R Now listed Silent mutation no 0 +Amikacin Rv2477c c.156C>G Rv2477c_c.156C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.1605C>T Rv2477c_c.1605C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 8 2460 21970 0 0 0.00149842073847528 0.999635999635999 0.999282900840091 0.999842837798826 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.2353912865109 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.1620C>T Rv2477c_c.1620C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.1638A>G Rv2477c_c.1638A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.1659C>T Rv2477c_c.1659C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.165C>T Rv2477c_c.165C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 21.6259333410942 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 37.2625869115887 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.1663C>T Rv2477c_c.1663C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.1674C>T Rv2477c_c.1674C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.201C>A Rv2477c_c.201C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.-20C>G Rv2477c_c.-20C>G 2 upstream_gene_variant 2784062 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c c.-25A>C Rv2477c_c.-25A>C 2 upstream_gene_variant 2784067 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c c.309C>T Rv2477c_c.309C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 13.5427650126618 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.312C>T Rv2477c_c.312C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 13.5427650126618 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 1111 7769 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.6044836876068 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.318C>T Rv2477c_c.318C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 12 2460 21966 0 0 0.00149842073847528 0.999453999453999 0.999046441372309 0.999717842739244 0 0 0.264648469397051 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.21614145803178 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 6 1111 7767 0 0 0.00331481736263177 0.999228097259745 0.998320655545558 0.999716674296114 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 5.94541565066903 NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.-31A>G Rv2477c_c.-31A>G 2 upstream_gene_variant 2784073 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c c.352C>T Rv2477c_c.352C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.-36A>C Rv2477c_c.-36A>C 2 upstream_gene_variant 2784078 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c c.387G>A Rv2477c_c.387G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.393C>T Rv2477c_c.393C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 10 2460 21968 0 0 0.00149842073847528 0.999544999544999 0.999163397681526 0.999781788721324 0 0 0.30849710781876 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.98680916993403 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 8 1111 7765 0 0 0.00331481736263177 0.998970796346327 0.997973071099689 0.99955556151365 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.10060236216416 NA NA NA NA NA NA 17 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.396C>T Rv2477c_c.396C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.417G>A Rv2477c_c.417G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.429G>A Rv2477c_c.429G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.-44G>A Rv2477c_c.-44G>A 2 upstream_gene_variant 2784086 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c c.45C>T Rv2477c_c.45C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.489C>T Rv2477c_c.489C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.48C>T Rv2477c_c.48C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.492G>A Rv2477c_c.492G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.-4C>T Rv2477c_c.-4C>T 2 upstream_gene_variant 2784046 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c c.538C>T Rv2477c_c.538C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.541T>C Rv2477c_c.541T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 7 20 2453 21958 0.00284552845528455 0.00114479164591456 0.00585403416056955 0.999089999089999 0.998594925555303 0.999444061992291 0.259259259259259 0.111144562845442 0.462848742276171 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.13302079086832 1.11806982802542 7.72211271121496 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 6 5 1105 7768 0.0054005400540054 0.00198440436427563 0.0117173898239407 0.999356747716454 0.998499507558406 0.999791105797204 0.545454545454545 0.233793597659345 0.832511905936292 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 8.43583710407239 2.1401298713059 34.9948589228155 NA NA NA NA NA NA 17 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.546G>A Rv2477c_c.546G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.558G>A Rv2477c_c.558G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.-55G>A Rv2477c_c.-55G>A 2 upstream_gene_variant 2784097 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c c.585G>A Rv2477c_c.585G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.612C>T Rv2477c_c.612C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.615C>T Rv2477c_c.615C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.618C>T Rv2477c_c.618C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 13.5427650126618 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 16.9345443329059 NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.627C>T Rv2477c_c.627C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.639C>T Rv2477c_c.639C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.655C>T Rv2477c_c.655C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.69C>T Rv2477c_c.69C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.702C>A Rv2477c_c.702C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.708C>A Rv2477c_c.708C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.708C>T Rv2477c_c.708C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.723C>T Rv2477c_c.723C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 21.6259333410942 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 16.9345443329059 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.-72T>C Rv2477c_c.-72T>C 2 upstream_gene_variant 2784114 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1827 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 980 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c c.-73C>G Rv2477c_c.-73C>G 2 upstream_gene_variant 2784115 1 3 0 3 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 21.6249500611508 1 662.5 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 271.670627328402 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c c.753G>A Rv2477c_c.753G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 13.5427650126618 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 37.2625869115887 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.-75G>A Rv2477c_c.-75G>A 2 upstream_gene_variant 2784117 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c c.762G>A Rv2477c_c.762G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.-76C>G Rv2477c_c.-76C>G 2 upstream_gene_variant 2784118 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c c.-78delG Rv2477c_c.-78delG 2 upstream_gene_variant 2784119 NA 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1828 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c c.801C>T Rv2477c_c.801C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.-81G>A Rv2477c_c.-81G>A 2 upstream_gene_variant 2784123 1 9 0 9 0 10 2460 21968 0 0 0.00149842073847528 0.999544999544999 0.999163397681526 0.999781788721324 0 0 0.30849710781876 0 0 0.336267116879942 0 0 0.30849710781876 0 0 4.52722867409844 0.612224497730614 117 1832 False False 0 0 3.98680916993403 0 0 0.00149842073847528 0.999544999544999 0.999163397681526 0.999781788721324 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 19 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c c.81T>C Rv2477c_c.81T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.831C>T Rv2477c_c.831C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 2460 21973 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.75275991328737 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 37.2625869115887 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.846C>G Rv2477c_c.846C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.879G>A Rv2477c_c.879G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.885A>C Rv2477c_c.885A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.894G>C Rv2477c_c.894G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.897G>A Rv2477c_c.897G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.-8A>G Rv2477c_c.-8A>G 2 upstream_gene_variant 2784050 1 7 0 7 0 9 2460 21969 0 0 0.00149842073847528 0.999590499590499 0.999222783640785 0.999812733785825 0 0 0.336267116879942 0 0 0.409616397225003 0 0 0.336267116879942 0 0 6.20003149897169 1 662.5 1832 False False 0 0 4.52743474605681 0 0 0.00149842073847528 0.999590499590499 0.999222783640785 0.999812733785825 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 27 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c c.90G>A Rv2477c_c.90G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.918C>T Rv2477c_c.918C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.948C>G Rv2477c_c.948C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 47 2457 21931 0.00121951219512195 0.00025156337591866 0.00355975660270706 0.997861497861498 0.9971572485627 0.998428298886553 0.06 0.012548587835334 0.165481946603772 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.569739952718676 0.113326901552221 1.77205516067058 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 37.2625869115887 NA NA NA NA NA NA 58 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.96C>T Rv2477c_c.96C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c c.9G>A Rv2477c_c.9G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 2460 21972 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.5904311186467 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin Rv2477c LoF Rv2477c_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1832 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Ala134Val Rv2477c_p.Ala134Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Ala139Val Rv2477c_p.Ala139Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1805 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Ala260Val Rv2477c_p.Ala260Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Ala277Thr Rv2477c_p.Ala277Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1825 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Ala277Val Rv2477c_p.Ala277Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1829 1832 False False Inf 0.22908065008664 Inf 0 0 0.00149902964335061 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1110 7773 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 1 0.999525536566873 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 981 981 False False 0 0 0 0 0 0 0 Inf 0.179394825906045 Inf 0 0 0.00331779872508707 1 0.999525536566873 1 NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Ala286Ser Rv2477c_p.Ala286Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Ala2Val Rv2477c_p.Ala2Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Ala335Thr Rv2477c_p.Ala335Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 21.6259333410942 1 662.5 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Ala392Thr Rv2477c_p.Ala392Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Ala392Val Rv2477c_p.Ala392Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1826 1832 False False Inf 0.22908065008664 Inf 0 0 0.00149902964335061 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Ala424Val Rv2477c_p.Ala424Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 2460 21973 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 9.75275991328737 1 662.5 1832 False False 0 0 9.75275991328737 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Ala492Asp Rv2477c_p.Ala492Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Ala520Val Rv2477c_p.Ala520Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1799 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 970 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Ala52Thr Rv2477c_p.Ala52Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Ala531Pro Rv2477c_p.Ala531Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Ala531Thr Rv2477c_p.Ala531Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1821 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 977 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Ala65Val Rv2477c_p.Ala65Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 2 2 2458 21976 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.999908999909 0.999671315452743 0.999988979276808 0.5 0.067585986488543 0.932414013511457 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 4.47030105777054 0.0757408825090807 86.112140473524 0.272530357206529 83 1832 False False 8.94060211554109 0.647679042113151 123.448658884577 0.000406669377795852 1.02959242167344e-05 0.0022637116293895 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 2 2 1109 7771 0.0018001800180018 0.000218084550259369 0.00648759665094944 0.999742699086581 0.999070852951501 0.999968838146642 0.5 0.067585986488543 0.932414013511457 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 3.50360685302073 0.0593329857914967 67.4346118204826 0.330013475806522 36 981 False False 0 0 0 0 0 0 0 7.00721370604147 0.507241254242996 96.7648442783254 0.0009009009009009 2.28085759023601e-05 0.00500917409467553 0.999742699086581 0.999070852951501 0.999968838146642 1 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Ala68Val Rv2477c_p.Ala68Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 21.6259333410942 1 662.5 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 16.9345443329059 1 267 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 2 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Arg149Cys Rv2477c_p.Arg149Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Arg251Pro Rv2477c_p.Arg251Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1824 1832 False False Inf 0.22908065008664 Inf 0 0 0.00149902964335061 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1110 7773 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 1 0.999525536566873 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 979 981 False False 0 0 0 0 0 0 0 Inf 0.179394825906045 Inf 0 0 0.00331779872508707 1 0.999525536566873 1 NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Arg257Ser Rv2477c_p.Arg257Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Arg316His Rv2477c_p.Arg316His 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 47.551166952306 1 165 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 976 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Arg316Ser Rv2477c_p.Arg316Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Arg346Cys Rv2477c_p.Arg346Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 19 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Arg450Lys Rv2477c_p.Arg450Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 2459 21976 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999908999909 0.999671315452743 0.999988979276808 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5725909264282 1 662.5 1832 False False 4.46848312322082 0.0757100934104112 86.0774363890598 0 0 0.00149902964335061 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Arg450Thr Rv2477c_p.Arg450Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1814 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 12 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Arg499Cys Rv2477c_p.Arg499Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1830 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Arg504Cys Rv2477c_p.Arg504Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 346.519051274799 1 662.5 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Arg539Pro Rv2477c_p.Arg539Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Arg549Thr Rv2477c_p.Arg549Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Arg553His Rv2477c_p.Arg553His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Arg86His Rv2477c_p.Arg86His 2 missense_variant (see "Genomic_coordinates" sheet) 1 30 0 30 0 36 2460 21942 0 0 0.00149842073847528 0.998361998361998 0.997733029382952 0.998852508231344 0 0 0.0973937559144919 0 0 0.115703308222027 0 0 0.0973937559144919 0 0 1.16800360919582 0.0679717167307256 26 1832 False False 0 0 0.963221074457382 0 0 0.00149842073847528 0.998361998361998 0.997733029382952 0.998852508231344 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 7 1111 7766 0 0 0.00331481736263177 0.999099446803036 0.998145402056424 0.999637856686565 0 0 0.409616397225003 0 0 0.707598226178713 0 0 0.409616397225003 0 0 16.9258908082757 1 75.5 981 False False 0 0 0 0 0 0 0 0 0 4.85661817639599 0 0 0.00331481736263177 0.999099446803036 0.998145402056424 0.999637856686565 59 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Asn240Ser Rv2477c_p.Asn240Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Asn80Lys Rv2477c_p.Asn80Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1809 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Asn88Ser Rv2477c_p.Asn88Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Asp146Tyr Rv2477c_p.Asp146Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1806 1832 False False Inf 0.22908065008664 Inf 0 0 0.00149902964335061 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1110 7773 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 1 0.999525536566873 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 974 981 False False 0 0 0 0 0 0 0 Inf 0.179394825906045 Inf 0 0 0.00331779872508707 1 0.999525536566873 1 NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Asp22Asn Rv2477c_p.Asp22Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Asp230Gly Rv2477c_p.Asp230Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Asp339Glu Rv2477c_p.Asp339Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 23 0 23 0 25 2460 21953 0 0 0.00149842073847528 0.998862498862498 0.99832127875239 0.999263738201867 0 0 0.137185171530712 0 0 0.148185128915224 0 0 0.137185171530712 0 0 1.55365388317158 0.161746435880096 63 1832 False False 0 0 1.42002015291483 0 0 0.00149842073847528 0.998862498862498 0.99832127875239 0.999263738201867 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 3 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Asp374Asn Rv2477c_p.Asp374Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 37.2625869115887 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 9 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Asp503Asn Rv2477c_p.Asp503Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Asp503Gly Rv2477c_p.Asp503Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 13.5427650126618 1 662.5 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Asp516Glu Rv2477c_p.Asp516Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1812 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Asp517Ala Rv2477c_p.Asp517Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1807 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Asp517Asn Rv2477c_p.Asp517Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Asp517Gly Rv2477c_p.Asp517Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Asp543Tyr Rv2477c_p.Asp543Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 47.551166952306 1 165 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Asp55Ala Rv2477c_p.Asp55Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 2460 21973 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 13.5421472279808 1 662.5 1832 False False 0 0 9.75275991328737 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Asp95Asn Rv2477c_p.Asp95Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Asp95Gly Rv2477c_p.Asp95Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Gln140Glu Rv2477c_p.Gln140Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Gln196His Rv2477c_p.Gln196His 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 47.5490114093265 1 662.5 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Gln289Pro Rv2477c_p.Gln289Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Gln417His Rv2477c_p.Gln417His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Gln74His Rv2477c_p.Gln74His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Glu105Lys Rv2477c_p.Glu105Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Glu117Ala Rv2477c_p.Glu117Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Glu120Asp Rv2477c_p.Glu120Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Glu127Asp Rv2477c_p.Glu127Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Glu128Asp Rv2477c_p.Glu128Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Glu224Lys Rv2477c_p.Glu224Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1803 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 972 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Glu238Val Rv2477c_p.Glu238Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 346.534733964433 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Glu268Lys Rv2477c_p.Glu268Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Glu308Lys Rv2477c_p.Glu308Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 37.2625869115887 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 1 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Glu476Ala Rv2477c_p.Glu476Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 37.2625869115887 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Glu538_Leu540delinsVal Rv2477c_p.Glu538_Leu540delinsVal 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Glu81Lys Rv2477c_p.Glu81Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Glu90Asp Rv2477c_p.Glu90Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Glu91Asp Rv2477c_p.Glu91Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1797 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 969 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Glu91Gly Rv2477c_p.Glu91Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Gly123Asp Rv2477c_p.Gly123Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 346.534733964433 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Gly162Ser Rv2477c_p.Gly162Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1791 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Gly207Asp Rv2477c_p.Gly207Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Gly207Ser Rv2477c_p.Gly207Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Gly256Ser Rv2477c_p.Gly256Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Gly314Arg Rv2477c_p.Gly314Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1817 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Gly409Ser Rv2477c_p.Gly409Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1810 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 975 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 1 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Gly41Glu Rv2477c_p.Gly41Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 313 3 310 8 333 2452 21645 0.0032520325203252 0.00140501011649083 0.00639769284617963 0.984848484848484 0.98314506726391 0.986421842429225 0.0234604105571847 0.0101817149741696 0.0457013246139585 0.00958466453674121 0.00198096660172685 0.0277534341205064 0.00892857142857142 0.00184508452509428 0.0258699737217251 0.0854273009524811 0.0175084839580308 0.252319940950423 3.94587918041967e-11 3 1832 True False 0.212071778140293 0.0906751060316638 0.423501670947245 0.00122199592668024 0.000252075869192596 0.00356699809904959 0.984848484848484 0.98314506726391 0.986421842429225 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 28 0 28 0 28 1111 7745 0 0 0.00331481736263177 0.996397787212144 0.994797976240739 0.997605061613023 0 0 0.123436118500263 0 0 0.123436118500263 0 0 0.123436118500263 0 0 0.983482088081861 0.0417902627473264 15 981 False False 0 0 0 0 0 0 0 0 0 0.983482088081861 0 0 0.00331481736263177 0.996397787212144 0.994797976240739 0.997605061613023 47 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Gly433Val Rv2477c_p.Gly433Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Gly441Ala Rv2477c_p.Gly441Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 9 2460 21969 0 0 0.00149842073847528 0.999590499590499 0.999222783640785 0.999812733785825 0 0 0.336267116879942 0 0 0.4592581264399 0 0 0.336267116879942 0 0 7.58939472197272 1 165 1832 False False 0 0 4.52743474605681 0 0 0.00149842073847528 0.999590499590499 0.999222783640785 0.999812733785825 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 7 1111 7766 0 0 0.00331481736263177 0.999099446803036 0.998145402056424 0.999637856686565 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 5.94465031655427 1 267 981 False False 0 0 0 0 0 0 0 0 0 4.85661817639599 0 0 0.00331481736263177 0.999099446803036 0.998145402056424 0.999637856686565 26 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Gly530Asp Rv2477c_p.Gly530Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Gly558Asp Rv2477c_p.Gly558Asp 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 2458 21978 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 1 0.99983216990204 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1815 1832 False False Inf 1.67834993427241 Inf 0 0 0.00149963904330158 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Gly87Arg Rv2477c_p.Gly87Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Gly87Ser Rv2477c_p.Gly87Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1831 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.His189Tyr Rv2477c_p.His189Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 13 1 12 1 13 2459 21965 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999408499408499 0.998988728376916 0.999685014453566 0.0714285714285714 0.00180678065912538 0.338684489931821 0.0769230769230769 0.00194562849734675 0.360297435267877 0.0714285714285714 0.00180678065912538 0.338684489931821 0.74437440694049 0.0174061578408797 5.03485448061752 1 662.5 1832 False False 0.687114837175837 0.0161617294058642 4.57837625710886 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999408499408499 0.998988728376916 0.999685014453566 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 1 8 1 9 1110 7764 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.998842145889618 0.997803175208698 0.999470423012169 0.1 0.00252857854446178 0.445016117028195 0.111111111111111 0.00280913674659921 0.482496514917337 0.1 0.00252857854446178 0.445016117028195 0.874324324324324 0.0196865704817122 6.53207967388882 1 267 981 False False 0 0 0 0 0 0 0 0.777177177177177 0.0177154135475561 5.61711233184972 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.998842145889618 0.997803175208698 0.999470423012169 14 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.His201Asp Rv2477c_p.His201Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1813 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.His326Arg Rv2477c_p.His326Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1818 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.His548Arg Rv2477c_p.His548Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Ile20Val Rv2477c_p.Ile20Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1790 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 967 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Ile311Met Rv2477c_p.Ile311Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1800 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 971 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Ile396Val Rv2477c_p.Ile396Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Ile464Val Rv2477c_p.Ile464Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Leu109Phe Rv2477c_p.Leu109Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1819 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Leu148Pro Rv2477c_p.Leu148Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1792 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Leu198Val Rv2477c_p.Leu198Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Leu288Val Rv2477c_p.Leu288Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 17 1 16 3 17 2457 21961 0.00121951219512195 0.00025156337591866 0.00355975660270706 0.999226499226499 0.99876183824676 0.999549344777619 0.15 0.0320709371854637 0.378926826545313 0.0588235294117647 0.00148817439126663 0.28688939666722 0.0555555555555555 0.00140555616736942 0.272943599673368 0.558633496133496 0.0133189559689816 3.59915594277605 1 662.5 1832 False False 1.57731810672987 0.295964682533419 5.45915054819239 0.000406834825061025 1.03001129356897e-05 0.00226463172978561 0.999226499226499 0.99876183824676 0.999549344777619 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 8 1111 7765 0 0 0.00331481736263177 0.998970796346327 0.997973071099689 0.99955556151365 0 0 0.369416647552819 0 0 0.409616397225003 0 0 0.369416647552819 0 0 4.85599295386197 0.607102035546344 45 981 False False 0 0 0 0 0 0 0 0 0 4.10060236216416 0 0 0.00331481736263177 0.998970796346327 0.997973071099689 0.99955556151365 22 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Leu327His Rv2477c_p.Leu327His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Leu327Phe Rv2477c_p.Leu327Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 21.6249500611508 1 662.5 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Leu370Arg Rv2477c_p.Leu370Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Leu455Ser Rv2477c_p.Leu455Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.22908065008664 Inf 0.100662902037809 42.5 1832 False False Inf 0.22908065008664 Inf 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1110 7773 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 1 0.999525536566873 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.179394825906045 Inf 0.125056280954525 25.5 981 False False 0 0 0 0 0 0 0 Inf 0.179394825906045 Inf 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 1 0.999525536566873 1 1 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Leu473Arg Rv2477c_p.Leu473Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1793 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Leu481Val Rv2477c_p.Leu481Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Leu486Arg Rv2477c_p.Leu486Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Leu540Phe Rv2477c_p.Leu540Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 13.5427650126618 1 662.5 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Leu73Pro Rv2477c_p.Leu73Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.22908065008664 Inf 0.100662902037809 42.5 1832 False False Inf 0.22908065008664 Inf 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Lys278Asn Rv2477c_p.Lys278Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Lys303Glu Rv2477c_p.Lys303Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Lys33Asn Rv2477c_p.Lys33Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 1 6 1 8 2459 21970 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999635999635999 0.999282900840091 0.999842837798826 0.111111111111111 0.00280913674659921 0.482496514917337 0.142857142857142 0.00361029686190058 0.578723197043195 0.111111111111111 0.00280913674659921 0.482496514917337 1.48908770502914 0.0323601401337089 12.2816693969249 0.524240003102797 110 1832 False False 1.11681577877185 0.0251588722809246 8.33607459248682 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999635999635999 0.999282900840091 0.999842837798826 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 5 1111 7768 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 10.6031190678859 1 75.5 981 False False 0 0 0 0 0 0 0 0 0 7.63947436138835 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 1 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Lys379Asn Rv2477c_p.Lys379Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 2460 21973 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 13.5421472279808 1 662.5 1832 False False 0 0 9.75275991328737 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 2 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Lys385Thr Rv2477c_p.Lys385Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Lys458Asn Rv2477c_p.Lys458Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Lys458Glu Rv2477c_p.Lys458Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Met93Ile Rv2477c_p.Met93Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 2 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Phe306Ser Rv2477c_p.Phe306Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Pro186Leu Rv2477c_p.Pro186Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Pro236His Rv2477c_p.Pro236His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 346.534733964433 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Pro312Gln Rv2477c_p.Pro312Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1802 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Pro355Ser Rv2477c_p.Pro355Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1794 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Pro39Ser Rv2477c_p.Pro39Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 21 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Pro434Gln Rv2477c_p.Pro434Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 7 2460 21971 0 0 0.00149842073847528 0.999681499681499 0.999343878425726 0.999871937071415 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1823 1832 False False 0 0 6.20059597931892 0 0 0.00149842073847528 0.999681499681499 0.999343878425726 0.999871937071415 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 5 1111 7768 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 978 981 False False 0 0 0 0 0 0 0 0 0 7.63947436138835 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 1 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Pro489Leu Rv2477c_p.Pro489Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 346.534733964433 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Pro489Ser Rv2477c_p.Pro489Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 37.2625869115887 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Pro547Leu Rv2477c_p.Pro547Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1798 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Pro78Ala Rv2477c_p.Pro78Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Pro78Ser Rv2477c_p.Pro78Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Ser176Ala Rv2477c_p.Ser176Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1796 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Ser176Pro Rv2477c_p.Ser176Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Ser242Pro Rv2477c_p.Ser242Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Ser27Gly Rv2477c_p.Ser27Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 7 2460 21971 0 0 0.00149842073847528 0.999681499681499 0.999343878425726 0.999871937071415 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 6.20059597931892 1 662.5 1832 False False 0 0 6.20059597931892 0 0 0.00149842073847528 0.999681499681499 0.999343878425726 0.999871937071415 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Ser341Ala Rv2477c_p.Ser341Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Ser375Gly Rv2477c_p.Ser375Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1795 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 968 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Ser377Cys Rv2477c_p.Ser377Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Ser407Ala Rv2477c_p.Ser407Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1820 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Ser480Leu Rv2477c_p.Ser480Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Ter559Glnext*? Rv2477c_p.Ter559Glnext*? 2 stop_lost (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Thr187Ala Rv2477c_p.Thr187Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1822 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Thr267Ile Rv2477c_p.Thr267Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1804 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 973 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Thr362Ala Rv2477c_p.Thr362Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Thr372Lys Rv2477c_p.Thr372Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 0 12 2460 21966 0 0 0.00149842073847528 0.999453999453999 0.999046441372309 0.999717842739244 0 0 0.264648469397051 0 0 0.369416647552819 0 0 0.264648469397051 0 0 5.23443807703645 1 165 1832 False False 0 0 3.21614145803178 0 0 0.00149842073847528 0.999453999453999 0.999046441372309 0.999717842739244 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 4 1111 7769 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 37.2530040824069 1 75.5 981 False False 0 0 0 0 0 0 0 0 0 10.6044836876068 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 70 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Thr505Arg Rv2477c_p.Thr505Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Thr505Met Rv2477c_p.Thr505Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Thr551Ile Rv2477c_p.Thr551Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Thr7Met Rv2477c_p.Thr7Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Trp524Arg Rv2477c_p.Trp524Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Tyr114Asp Rv2477c_p.Tyr114Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Tyr114Cys Rv2477c_p.Tyr114Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Val313Leu Rv2477c_p.Val313Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Val313Phe Rv2477c_p.Val313Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 1 2458 21977 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.9999544999545 0.999746516336938 0.999998848039248 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 1801 1832 False False 17.8820179007323 0.930367849464557 1047.07427525324 0 0 0.00149963904330158 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Val320Met Rv2477c_p.Val320Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 6 2460 21972 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 0 0 0.4592581264399 0 0 0.602364635616474 0 0 0.4592581264399 0 0 13.5415294433897 1 165 1832 False False 0 0 7.5904311186467 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 37.2577954991549 1 267 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 3 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Val322Ile Rv2477c_p.Val322Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Val324Ala Rv2477c_p.Val324Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Val352Ala Rv2477c_p.Val352Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Val368Phe Rv2477c_p.Val368Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Val384Leu Rv2477c_p.Val384Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Val389_Asp390insGly Rv2477c_p.Val389_Asp390insGly 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Val389Ala Rv2477c_p.Val389Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Val405Gly Rv2477c_p.Val405Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 6 2460 21972 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1811 1832 False False 0 0 7.5904311186467 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Val406Phe Rv2477c_p.Val406Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Val420Ala Rv2477c_p.Val420Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Val426Ala Rv2477c_p.Val426Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Val426Met Rv2477c_p.Val426Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 8 2460 21970 0 0 0.00149842073847528 0.999635999635999 0.999282900840091 0.999842837798826 0 0 0.369416647552819 0 0 0.409616397225003 0 0 0.369416647552819 0 0 6.2003137391411 1 662.5 1832 False False 0 0 5.2353912865109 0 0 0.00149842073847528 0.999635999635999 0.999282900840091 0.999842837798826 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 1111 7767 0 0 0.00331481736263177 0.999228097259745 0.998320655545558 0.999716674296114 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 5.94541565066903 1 75.5 981 False False 0 0 0 0 0 0 0 0 0 5.94541565066903 0 0 0.00331481736263177 0.999228097259745 0.998320655545558 0.999716674296114 2 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Val493Met Rv2477c_p.Val493Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 346.534733964433 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Val550fs Rv2477c_p.Val550fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1816 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Val70Ala Rv2477c_p.Val70Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 47.5490114093265 1 662.5 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 4 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Val70Met Rv2477c_p.Val70Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Val85Ile Rv2477c_p.Val85Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 32 3 29 12 35 2448 21943 0.0048780487804878 0.00252302251619196 0.00850545023157134 0.998407498407498 0.997785905018943 0.998890521362752 0.25531914893617 0.139449120017569 0.403495189971568 0.09375 0.0197671801732848 0.250226950683794 0.0789473684210526 0.0165864758645295 0.213773291180618 0.927273495605138 0.180622210763699 2.994963219074 1 165 1832 False False 3.07324929971988 1.45042473507608 6.07264097845666 0.00122399020807833 0.000252487369724557 0.00357281254352548 0.998407498407498 0.997785905018943 0.998890521362752 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 16.9345443329059 1 267 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 90 3) Uncertain significance New Uncertain no 0 +Amikacin Rv2477c p.Val89Met Rv2477c_p.Val89Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-100G>A whiB6_c.-100G>A 2 upstream_gene_variant 4338621 1 3 0 3 0 5 2460 21973 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 21.6239667816724 1 662.5 1832 False False 0 0 9.75275991328737 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 271.670627328402 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 6 3) Uncertain significance No change no 1 +Amikacin whiB6 c.-101T>C whiB6_c.-101T>C 2 upstream_gene_variant 4338622 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-103C>G whiB6_c.-103C>G 2 upstream_gene_variant 4338624 NA 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1707 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 940 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-103C>T whiB6_c.-103C>T 2 upstream_gene_variant 4338624 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 37.2625869115887 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 3 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-104C>T whiB6_c.-104C>T 2 upstream_gene_variant 4338625 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-109C>A whiB6_c.-109C>A 2 upstream_gene_variant 4338630 1 11 0 11 0 16 2460 21962 0 0 0.00149842073847528 0.999271999271999 0.998818040931792 0.999583829243268 0 0 0.205907214207822 0 0 0.284914152918154 0 0 0.205907214207822 0 0 3.55957500648284 0.616677055542807 133 1832 False False 0 0 2.31664784301595 0 0 0.00149842073847528 0.999271999271999 0.998818040931792 0.999583829243268 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 8 1111 7765 0 0 0.00331481736263177 0.998970796346327 0.997973071099689 0.99955556151365 0 0 0.369416647552819 0 0 0.409616397225003 0 0 0.369416647552819 0 0 4.85599295386197 0.607102035546344 45 981 False False 0 0 0 0 0 0 0 0 0 4.10060236216416 0 0 0.00331481736263177 0.998970796346327 0.997973071099689 0.99955556151365 23 3) Uncertain significance No change no 1 +Amikacin whiB6 c.-10G>A whiB6_c.-10G>A 2 upstream_gene_variant 4338531 1 3 0 3 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 21.6259333410942 1 662.5 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin whiB6 c.-110T>C whiB6_c.-110T>C 2 upstream_gene_variant 4338631 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 c.-110T>G whiB6_c.-110T>G 2 upstream_gene_variant 4338631 1 3 0 3 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 21.6259333410942 1 662.5 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 2 3) Uncertain significance No change no 1 +Amikacin whiB6 c.-112_-111insTTAACAGG whiB6_c.-112_-111insTTAACAGG 2 upstream_gene_variant 4338632 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-113G>C whiB6_c.-113G>C 2 upstream_gene_variant 4338634 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 4 3) Uncertain significance No change no 1 +Amikacin whiB6 c.-114A>C whiB6_c.-114A>C 2 upstream_gene_variant 4338635 1 38 1 37 1 39 2459 21939 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.998225498225498 0.99757498778433 0.998737860848152 0.025 0.000632744932049419 0.131585858482765 0.0263157894736842 0.000666036204202366 0.13809902979242 0.025 0.000632744932049419 0.131585858482765 0.24113295890441 0.00594720797608927 1.43093204507641 0.17509375485987 64 1832 False False 0.228767166140081 0.00564994912636561 1.3532293727724 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.998225498225498 0.99757498778433 0.998737860848152 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 8 1111 7765 0 0 0.00331481736263177 0.998970796346327 0.997973071099689 0.99955556151365 0 0 0.369416647552819 0 0 0.409616397225003 0 0 0.369416647552819 0 0 4.85599295386197 0.607102035546344 45 981 False False 0 0 0 0 0 0 0 0 0 4.10060236216416 0 0 0.00331481736263177 0.998970796346327 0.997973071099689 0.99955556151365 70 3) Uncertain significance No change no 1 +Amikacin whiB6 c.-114A>G whiB6_c.-114A>G 2 upstream_gene_variant 4338635 1 5 0 5 1 5 2459 21973 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999772499772499 0.99946917089695 0.999926127301238 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.521823750104981 0 0 0.521823750104981 0 0 9.756727664523 1 662.5 1832 False False 1.78714924766165 0.0377700438379967 15.9793065569956 0 0 0.00149902964335061 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 3 1110 7770 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.999614048629872 0.998872504682436 0.999920400475616 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 16.9497011919479 1 267 981 False False 0 0 0 0 0 0 0 2.33333333333333 0.0444070764861474 29.0856116545381 0 0 0.00331779872508707 0.999614048629872 0.998872504682436 0.999920400475616 2 3) Uncertain significance No change no 1 +Amikacin whiB6 c.-114A>T whiB6_c.-114A>T 2 upstream_gene_variant 4338635 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin whiB6 c.-115_-114insT whiB6_c.-115_-114insT 2 upstream_gene_variant 4338635 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 c.-115_-23delCAGGATCTATGCCCTGGTACTCGGCGGTGCGCGCACTAGAGCTCGGAGCTCGCCGAACCGGAGCCGCAGCACCGCTAGGCAGGCAGAGGAGGA whiB6_c.-115_-23delCAGGATCTATGCCCTGGTACTCGGCGGTGCGCGCACTAGAGCTCGGAGCTCGCCGAACCGGAGCCGCAGCACCGCTAGGCAGGCAGAGGAGGA 2 upstream_gene_variant 4338543 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-115C>A whiB6_c.-115C>A 2 upstream_gene_variant 4338636 1 3 0 3 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 21.6259333410942 1 662.5 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 37.2625869115887 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 NA 3) Uncertain significance No change no 1 +Amikacin whiB6 c.-116A>C whiB6_c.-116A>C 2 upstream_gene_variant 4338637 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 12 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-117A>G whiB6_c.-117A>G 2 upstream_gene_variant 4338638 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-119T>G whiB6_c.-119T>G 2 upstream_gene_variant 4338640 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin whiB6 c.-11C>G whiB6_c.-11C>G 2 upstream_gene_variant 4338532 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1656 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 c.-122_-104delTGATTAACAGGATCTATGC whiB6_c.-122_-104delTGATTAACAGGATCTATGC 2 upstream_gene_variant 4338624 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-122T>C whiB6_c.-122T>C 2 upstream_gene_variant 4338643 1 1 0 1 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 346.534733964433 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Amikacin whiB6 c.-123_-34delCTGATTAACAGGATCTATGCCCTGGTACTCGGCGGTGCGCGCACTAGAGCTCGGAGCTCGCCGAACCGGAGCCGCAGCACCGCTAGGCAG whiB6_c.-123_-34delCTGATTAACAGGATCTATGCCCTGGTACTCGGCGGTGCGCGCACTAGAGCTCGGAGCTCGCCGAACCGGAGCCGCAGCACCGCTAGGCAG 2 upstream_gene_variant 4338554 1 0 0 0 1 1 2459 21977 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.9999544999545 0.999746516336938 0.999998848039248 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1663 1832 False False 8.93737291581943 0.113810496005924 697.318539256027 0 0 0.00149902964335061 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-125_-124insA whiB6_c.-125_-124insA 2 upstream_gene_variant 4338645 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-125A>C whiB6_c.-125A>C 2 upstream_gene_variant 4338646 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Amikacin whiB6 c.-125A>G whiB6_c.-125A>G 2 upstream_gene_variant 4338646 1 9 0 9 0 13 2460 21965 0 0 0.00149842073847528 0.999408499408499 0.998988728376916 0.999685014453566 0 0 0.24705263800047 0 0 0.336267116879942 0 0 0.24705263800047 0 0 4.52661045825463 0.612219522003239 114 1832 False False 0 0 2.93170145225031 0 0 0.00149842073847528 0.999408499408499 0.998988728376916 0.999685014453566 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 5 1111 7768 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 16.930217557563 1 267 981 False False 0 0 0 0 0 0 0 0 0 7.63947436138835 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 2 3) Uncertain significance No change no 1 +Amikacin whiB6 c.-126C>A whiB6_c.-126C>A 2 upstream_gene_variant 4338647 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-126C>G whiB6_c.-126C>G 2 upstream_gene_variant 4338647 1 1 0 1 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 346.503368577436 1 662.5 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 902 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance No change no 1 +Amikacin whiB6 c.-126C>T whiB6_c.-126C>T 2 upstream_gene_variant 4338647 1 3 0 3 1 3 2459 21975 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.9998634998635 0.999601141012814 0.999971849505602 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 21.6347237132381 1 165 1832 False False 2.97885319235461 0.0567200675769732 37.1234870649317 0 0 0.00149902964335061 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Amikacin whiB6 c.12T>C whiB6_c.12T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin whiB6 c.-12T>C whiB6_c.-12T>C 2 upstream_gene_variant 4338533 1 4 0 4 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 13.5427650126618 1 662.5 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Amikacin whiB6 c.138C>T whiB6_c.138C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 37.2625869115887 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin whiB6 c.-13A>G whiB6_c.-13A>G 2 upstream_gene_variant 4338534 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 c.-14C>T whiB6_c.-14C>T 2 upstream_gene_variant 4338535 1 8 0 8 0 9 2460 21969 0 0 0.00149842073847528 0.999590499590499 0.999222783640785 0.999812733785825 0 0 0.336267116879942 0 0 0.369416647552819 0 0 0.336267116879942 0 0 5.23515298412767 1 662.5 1832 False False 0 0 4.52743474605681 0 0 0.00149842073847528 0.999590499590499 0.999222783640785 0.999812733785825 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 37.2625869115887 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 22 3) Uncertain significance No change no 1 +Amikacin whiB6 c.150G>A whiB6_c.150G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin whiB6 c.159C>T whiB6_c.159C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin whiB6 c.-15G>T whiB6_c.-15G>T 2 upstream_gene_variant 4338536 NA 0 0 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1694 1832 False False Inf 0.22908065008664 Inf 0 0 0.00149902964335061 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-16T>C whiB6_c.-16T>C 2 upstream_gene_variant 4338537 1 14 0 14 0 16 2460 21962 0 0 0.00149842073847528 0.999271999271999 0.998818040931792 0.999583829243268 0 0 0.205907214207822 0 0 0.231635761650116 0 0 0.205907214207822 0 0 2.69332095317621 0.386913826960973 91 1832 False False 0 0 2.31664784301595 0 0 0.00149842073847528 0.999271999271999 0.998818040931792 0.999583829243268 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 37.2625869115887 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 28 3) Uncertain significance No change no 1 +Amikacin whiB6 c.171G>A whiB6_c.171G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin whiB6 c.174C>T whiB6_c.174C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin whiB6 c.-17T>C whiB6_c.-17T>C 2 upstream_gene_variant 4338538 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin whiB6 c.-182_-115delTTTTCCTGGAAGATCTGCCCGAAGGGGTCGGATACGCGCCGGCGAGGCCAGATACACAGCTGATTAAC whiB6_c.-182_-115delTTTTCCTGGAAGATCTGCCCGAAGGGGTCGGATACGCGCCGGCGAGGCCAGATACACAGCTGATTAAC 2 upstream_gene_variant 4338635 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-183_-34del whiB6_c.-183_-34del 2 upstream_gene_variant 4338554 NA 0 0 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1714 1832 False False Inf 0.22908065008664 Inf 0 0 0.00149902964335061 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-184_-44del whiB6_c.-184_-44del 2 upstream_gene_variant 4338564 1 4 0 4 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 13.5427650126618 1 662.5 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-186_-28del whiB6_c.-186_-28del 2 upstream_gene_variant 4338548 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-186_-29del whiB6_c.-186_-29del 2 upstream_gene_variant 4338549 1 2 0 2 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 47.551166952306 1 165 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 2 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-187_-31del whiB6_c.-187_-31del 2 upstream_gene_variant 4338551 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1701 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.18G>A whiB6_c.18G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.22908065008664 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin whiB6 c.-190_-40del whiB6_c.-190_-40del 2 upstream_gene_variant 4338560 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-192_-110delGTCAGAACACTTTTCCTGGAAGATCTGCCCGAAGGGGTCGGATACGCGCCGGCGAGGCCAGATACACAGCTGATTAACAGGAT whiB6_c.-192_-110delGTCAGAACACTTTTCCTGGAAGATCTGCCCGAAGGGGTCGGATACGCGCCGGCGAGGCCAGATACACAGCTGATTAACAGGAT 2 upstream_gene_variant 4338630 1 8 0 8 1 10 2459 21968 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999544999544999 0.999163397681526 0.999781788721324 0.0909090909090909 0.00229897221381426 0.412779916988382 0 0 0.369416647552819 0 0 0.30849710781876 0 0 5.2370449490847 1 662.5 1832 False False 0.893371289141927 0.020577382163102 6.28488216182158 0 0 0.00149902964335061 0.999544999544999 0.999163397681526 0.999781788721324 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.192C>A whiB6_c.192C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin whiB6 c.-195_-93del whiB6_c.-195_-93del 2 upstream_gene_variant 4338613 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.195C>T whiB6_c.195C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin whiB6 c.-198_-31del whiB6_c.-198_-31del 2 upstream_gene_variant 4338551 NA 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1703 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 938 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-198_-42del whiB6_c.-198_-42del 2 upstream_gene_variant 4338562 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.198C>T whiB6_c.198C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin whiB6 c.-19T>C whiB6_c.-19T>C 2 upstream_gene_variant 4338540 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Amikacin whiB6 c.1A>G whiB6_c.1A>G 2 initiator_codon_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 13.5427650126618 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 1111 7769 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.6044836876068 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin whiB6 c.1A>T whiB6_c.1A>T 2 initiator_codon_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.22908065008664 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin whiB6 c.-205_-62del whiB6_c.-205_-62del 2 upstream_gene_variant 4338582 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-206_-65del whiB6_c.-206_-65del 2 upstream_gene_variant 4338585 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.213T>C whiB6_c.213T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin whiB6 c.21A>C whiB6_c.21A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin whiB6 c.-21A>G whiB6_c.-21A>G 2 upstream_gene_variant 4338542 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 2 3) Uncertain significance No change no 1 +Amikacin whiB6 c.-22A>G whiB6_c.-22A>G 2 upstream_gene_variant 4338543 NA 0 0 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1648 1832 False False Inf 0.22908065008664 Inf 0 0 0.00149902964335061 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.231A>C whiB6_c.231A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 7 2460 21971 0 0 0.00149842073847528 0.999681499681499 0.999343878425726 0.999871937071415 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 6.20059597931892 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin whiB6 c.-240_-28del whiB6_c.-240_-28del 2 upstream_gene_variant 4338548 1 1 1 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.22908065008664 Inf 0.100662902037809 42.5 1832 False False Inf 0.22908065008664 Inf 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-24G>A whiB6_c.-24G>A 2 upstream_gene_variant 4338545 1 3 0 3 1 7 2459 21971 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999681499681499 0.999343878425726 0.999871937071415 0.125 0.0031597235312519 0.526509670875206 0 0 0.707598226178713 0 0 0.409616397225003 0 0 21.6307889797006 1 165 1832 False False 1.27641898565038 0.0283100041178698 9.94235653125396 0 0 0.00149902964335061 0.999681499681499 0.999343878425726 0.999871937071415 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 3 1110 7770 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.999614048629872 0.998872504682436 0.999920400475616 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 37.2913541593201 1 267 981 False False 0 0 0 0 0 0 0 2.33333333333333 0.0444070764861474 29.0856116545381 0 0 0.00331779872508707 0.999614048629872 0.998872504682436 0.999920400475616 5 3) Uncertain significance No change no 1 +Amikacin whiB6 c.-24G>C whiB6_c.-24G>C 2 upstream_gene_variant 4338545 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 c.-24G>T whiB6_c.-24G>T 2 upstream_gene_variant 4338545 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin whiB6 c.258G>A whiB6_c.258G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.22908065008664 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 1110 7773 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 1 0.999525536566873 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.179394825906045 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin whiB6 c.-25G>A whiB6_c.-25G>A 2 upstream_gene_variant 4338546 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance No change no 1 +Amikacin whiB6 c.-26A>C whiB6_c.-26A>C 2 upstream_gene_variant 4338547 1 5 0 5 0 5 2460 21973 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 9.75275991328737 1 662.5 1832 False False 0 0 9.75275991328737 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Amikacin whiB6 c.-26A>G whiB6_c.-26A>G 2 upstream_gene_variant 4338547 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 3) Uncertain significance No change no 1 +Amikacin whiB6 c.-27_-26insG whiB6_c.-27_-26insG 2 upstream_gene_variant 4338547 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-27G>A whiB6_c.-27G>A 2 upstream_gene_variant 4338548 1 5 0 5 0 5 2460 21973 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 9.75275991328737 1 662.5 1832 False False 0 0 9.75275991328737 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 37.2625869115887 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 2 3) Uncertain significance No change no 1 +Amikacin whiB6 c.-27G>C whiB6_c.-27G>C 2 upstream_gene_variant 4338548 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.288A>G whiB6_c.288A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 24 58 2436 21920 0.00975609756097561 0.00626063537842125 0.0144817247141775 0.997360997360997 0.996589795356983 0.997995503386568 0.292682926829268 0.197353323187852 0.403520422814188 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.72345846781043 2.20794287182139 6.09971550877804 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 13 52 1098 7721 0.0117011701170117 0.00624468447090962 0.019926240522104 0.993310176251125 0.991236331372861 0.994999801489488 0.2 0.111015834886745 0.31768797188169 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.75796903460837 0.875114281648586 3.28693221970656 NA NA NA NA NA NA 16 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin whiB6 c.294G>A whiB6_c.294G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin whiB6 c.-29A>G whiB6_c.-29A>G 2 upstream_gene_variant 4338550 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-29A>T whiB6_c.-29A>T 2 upstream_gene_variant 4338550 1 5 0 5 0 5 2460 21973 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 9.75275991328737 1 662.5 1832 False False 0 0 9.75275991328737 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 1111 7768 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 7.63947436138835 1 75.5 981 False False 0 0 0 0 0 0 0 0 0 7.63947436138835 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 10 3) Uncertain significance No change no 1 +Amikacin whiB6 c.-2T>C whiB6_c.-2T>C 2 upstream_gene_variant 4338523 1 4 0 4 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 13.5427650126618 1 662.5 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin whiB6 c.303C>G whiB6_c.303C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin whiB6 c.30A>G whiB6_c.30A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin whiB6 c.-30G>C whiB6_c.-30G>C 2 upstream_gene_variant 4338551 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.312C>T whiB6_c.312C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin whiB6 c.318G>T whiB6_c.318G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin whiB6 c.-31A>G whiB6_c.-31A>G 2 upstream_gene_variant 4338552 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin whiB6 c.324C>T whiB6_c.324C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin whiB6 c.330G>A whiB6_c.330G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin whiB6 c.-33G>A whiB6_c.-33G>A 2 upstream_gene_variant 4338554 NA 0 0 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1653 1832 False False Inf 0.22908065008664 Inf 0 0 0.00149902964335061 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1110 7773 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 1 0.999525536566873 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 906 981 False False 0 0 0 0 0 0 0 Inf 0.179394825906045 Inf 0 0 0.00331779872508707 1 0.999525536566873 1 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-33G>C whiB6_c.-33G>C 2 upstream_gene_variant 4338554 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 c.-34G>A whiB6_c.-34G>A 2 upstream_gene_variant 4338555 1 1 1 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.22908065008664 Inf 0.100662902037809 42.5 1832 False False Inf 0.22908065008664 Inf 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 c.-42G>T whiB6_c.-42G>T 2 upstream_gene_variant 4338563 1 108 2 106 60 314 2400 21664 0.024390243902439 0.0186627223160554 0.0312847267149591 0.985712985712985 0.984055451802683 0.987240158702501 0.160427807486631 0.124711551028367 0.201623597665292 0.0185185185185185 0.00225059950165782 0.0652965469444737 0.00632911392405063 0.000767406208532308 0.0226747081093612 0.170314465408805 0.0203524197096236 0.631342200090011 0.00185295171689995 11 1832 False False 1.72484076433121 1.28189832902299 2.28771563776267 0.000832639467110741 0.000100852413207082 0.00300451064960917 0.985712985712985 0.984055451802683 0.987240158702501 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 100 2 98 52 258 1059 7515 0.0468046804680468 0.0351504232714423 0.060927941353741 0.966808182169046 0.962582418414644 0.970678993595717 0.16774193548387 0.127887691295289 0.214081441864243 0.02 0.00243133682394254 0.0703839324710701 0.00769230769230769 0.000932935506064702 0.0275094647749558 0.144822801641903 0.0172983830284337 0.53881412579155 0.000542161304427717 5 981 False False 0 0 0 0 0 0 0 1.43026549838592 1.03329298013255 1.94792376516454 0.00188501413760603 0.00022836553555476 0.00679257422176737 0.966808182169046 0.962582418414644 0.970678993595717 368 3) Uncertain significance No change no 1 +Amikacin whiB6 c.42T>G whiB6_c.42T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 21.6259333410942 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 37.2625869115887 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin whiB6 c.-44C>T whiB6_c.-44C>T 2 upstream_gene_variant 4338565 1 3 0 3 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 21.6259333410942 1 662.5 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 3) Uncertain significance No change no 1 +Amikacin whiB6 c.45C>T whiB6_c.45C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin whiB6 c.-46C>A whiB6_c.-46C>A 2 upstream_gene_variant 4338567 NA 0 0 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1692 1832 False False Inf 0.22908065008664 Inf 0 0 0.00149902964335061 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1110 7773 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 1 0.999525536566873 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 931 981 False False 0 0 0 0 0 0 0 Inf 0.179394825906045 Inf 0 0 0.00331779872508707 1 0.999525536566873 1 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.49A>C whiB6_c.49A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 14 27 2446 21951 0.0056910569105691 0.00311474206131312 0.00953020851427521 0.998771498771498 0.998213094756864 0.999190258727253 0.341463414634146 0.200834113717082 0.505947473605733 NA NA NA NA NA NA NA NA NA NA NA NA False False 4.65331152902698 2.25178355528163 9.2042371188305 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 1110 7772 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.99987134954329 0.999283416286792 0.999996742857744 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 7.0018018018018 0.0891187877143753 547.10724479397 NA NA NA NA NA NA 22 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin whiB6 c.-49C>T whiB6_c.-49C>T 2 upstream_gene_variant 4338570 1 1 0 1 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 346.534733964433 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 c.-54A>G whiB6_c.-54A>G 2 upstream_gene_variant 4338575 1 23 0 23 2 34 2458 21944 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.998452998452998 0.997838885013474 0.998928425907948 0.0555555555555555 0.00680030065402281 0.186636706457554 0 0 0.148185128915224 0 0 0.102817924259012 0 0 1.55429486551831 0.161734291917975 62 1832 False False 0.52515196477289 0.0610946805450263 2.05074838698149 0 0 0.00149963904330158 0.998452998452998 0.997838885013474 0.998928425907948 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 1111 7769 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 10.6044836876068 1 267 981 False False 0 0 0 0 0 0 0 0 0 10.6044836876068 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 36 3) Uncertain significance No change no 1 +Amikacin whiB6 c.-54A>T whiB6_c.-54A>T 2 upstream_gene_variant 4338575 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1683 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.54C>T whiB6_c.54C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 2460 21972 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.5904311186467 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin whiB6 c.-57C>G whiB6_c.-57C>G 2 upstream_gene_variant 4338578 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-59A>C whiB6_c.-59A>C 2 upstream_gene_variant 4338580 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 c.-5G>A whiB6_c.-5G>A 2 upstream_gene_variant 4338526 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1715 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 c.-62C>T whiB6_c.-62C>T 2 upstream_gene_variant 4338583 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1678 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Amikacin whiB6 c.-66T>C whiB6_c.-66T>C 2 upstream_gene_variant 4338587 1 27 0 27 1 27 2459 21951 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.998771498771498 0.998213094756864 0.999190258727253 0.0357142857142857 0.000903798755658059 0.183477597544623 0 0 0.127702867615432 0 0 0.127702867615432 0 0 1.30792729359033 0.105163016853889 58 1832 False False 0.330622204148027 0.00807523534936516 2.00770836805655 0 0 0.00149902964335061 0.998771498771498 0.998213094756864 0.999190258727253 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 27 0 27 0 27 1111 7746 0 0 0.00331481736263177 0.996526437668853 0.994950143627592 0.997709690585787 0 0 0.127702867615432 0 0 0.127702867615432 0 0 0.127702867615432 0 0 1.02259821329418 0.0415286146924437 13 981 False False 0 0 0 0 0 0 0 0 0 1.02259821329418 0 0 0.00331481736263177 0.996526437668853 0.994950143627592 0.997709690585787 2 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-67C>T whiB6_c.-67C>T 2 upstream_gene_variant 4338588 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-68G>T whiB6_c.-68G>T 2 upstream_gene_variant 4338589 1 2 1 1 1 2 2459 21976 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999908999909 0.999671315452743 0.999988979276808 0.333333333333333 0.00840375865961264 0.905700675949754 0.5 0.012579117093425 0.987420882906574 0.333333333333333 0.00840375865961264 0.905700675949754 8.93696624644164 0.113805317387077 697.287017600128 0.191203898368438 78.5 1832 False False 4.46848312322082 0.0757100934104112 86.0774363890598 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-69A>C whiB6_c.-69A>C 2 upstream_gene_variant 4338590 1 5 0 5 0 5 2460 21973 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 9.75275991328737 1 662.5 1832 False False 0 0 9.75275991328737 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 1111 7769 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 10.6044836876068 1 267 981 False False 0 0 0 0 0 0 0 0 0 10.6044836876068 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 75 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-69A>G whiB6_c.-69A>G 2 upstream_gene_variant 4338590 1 1 0 1 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 346.519051274799 1 662.5 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 271.670627328402 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 1 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-69A>T whiB6_c.-69A>T 2 upstream_gene_variant 4338590 1 4 0 4 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 13.5427650126618 1 662.5 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 16.9345443329059 1 267 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 19 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-70G>A whiB6_c.-70G>A 2 upstream_gene_variant 4338591 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-70G>C whiB6_c.-70G>C 2 upstream_gene_variant 4338591 1 15 1 14 12 29 2448 21949 0.0048780487804878 0.00252302251619196 0.00850545023157134 0.998680498680498 0.998105521382019 0.999116136718959 0.292682926829268 0.161298569714307 0.455373983165363 0.0666666666666666 0.0016864302413527 0.319484566578303 0.0333333333333333 0.000843570926630479 0.172169455633412 0.640435340802987 0.0151430903172711 4.2128630258081 1 662.5 1832 False False 3.71010818120351 1.7218791165804 7.50754794296083 0.000408329930583911 1.03379653396299e-05 0.00227294641518986 0.998680498680498 0.998105521382019 0.999116136718959 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 2 2 1109 7771 0.0018001800180018 0.000218084550259369 0.00648759665094944 0.999742699086581 0.999070852951501 0.999968838146642 0.5 0.067585986488543 0.932414013511457 0 0 0.841886116991581 0 0 0.841886116991581 0 0 37.3297731452792 1 267 981 False False 0 0 0 0 0 0 0 7.00721370604147 0.507241254242996 96.7648442783254 0 0 0.00332078545526824 0.999742699086581 0.999070852951501 0.999968838146642 8 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-71G>A whiB6_c.-71G>A 2 upstream_gene_variant 4338592 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-71G>C whiB6_c.-71G>C 2 upstream_gene_variant 4338592 1 3 0 3 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 21.6259333410942 1 662.5 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 37.2625869115887 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 8 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-71G>T whiB6_c.-71G>T 2 upstream_gene_variant 4338592 1 1 0 1 0 16 2460 21962 0 0 0.00149842073847528 0.999271999271999 0.998818040931792 0.999583829243268 0 0 0.205907214207822 0 0 0.975 0 0 0.205907214207822 0 0 346.315175606327 1 662.5 1832 False False 0 0 2.31664784301595 0 0 0.00149842073847528 0.999271999271999 0.998818040931792 0.999583829243268 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 943 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 7 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.72C>T whiB6_c.72C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin whiB6 c.-74delC whiB6_c.-74delC 2 upstream_gene_variant 4338594 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance No change no 1 +Amikacin whiB6 c.-75_-72delGCTCinsCAA whiB6_c.-75_-72delGCTCinsCAA 2 upstream_gene_variant 4338593 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-75_-72delGCTCinsCTG whiB6_c.-75_-72delGCTCinsCTG 2 upstream_gene_variant 4338593 1 4 0 4 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 13.5427650126618 1 662.5 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin whiB6 c.-75_-72delGCTCinsCTT whiB6_c.-75_-72delGCTCinsCTT 2 upstream_gene_variant 4338593 1 3 0 3 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 21.6259333410942 1 662.5 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance No change no 1 +Amikacin whiB6 c.-75_-73delGCTinsCA whiB6_c.-75_-73delGCTinsCA 2 upstream_gene_variant 4338594 1 19 1 18 1 20 2459 21958 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999089999089999 0.998594925555303 0.999444061992291 0.0476190476190476 0.00120488344836351 0.238159909936821 0.0526315789473684 0.00133162880417942 0.260280654195214 0.0476190476190476 0.00120488344836351 0.238159909936821 0.496091455424517 0.0119050523961384 3.14456655149422 0.714506586989732 141 1832 False False 0.446482309882065 0.0107708691055265 2.79415842032458 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999089999089999 0.998594925555303 0.999444061992291 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 271.670627328402 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 26 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-75_-73delGCTinsCC whiB6_c.-75_-73delGCTinsCC 2 upstream_gene_variant 4338594 NA 0 0 0 6 88 2454 21890 0.0024390243902439 0.000895588528695574 0.00530111511191433 0.995995995995996 0.99506924809324 0.996787470454259 0.0638297872340425 0.0237825602750493 0.133767590474289 NA NA NA 0 0 0.041052629058078 NA NA NA NA 1684 1832 False True 0.608190709046454 0.217083891147633 1.3795738336665 0 0 0.00150208160595732 0.995995995995996 0.99506924809324 0.996787470454259 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 2 52 1109 7721 0.0018001800180018 0.000218084550259369 0.00648759665094944 0.993310176251125 0.991236331372861 0.994999801489488 0.037037037037037 0.00451725629446049 0.127471772230947 NA NA NA 0 0 0.0684822087033195 NA NA NA NA 924 981 False True 0 1 1 0 0 0 0 0.267774155510855 0.0315488347135451 1.01975881240588 0 0 0.00332078545526824 0.993310176251125 0.991236331372861 0.994999801489488 68 5) Not assoc w R New NotAwR yes 5 +Amikacin whiB6 c.-75_-73delGCTinsCG whiB6_c.-75_-73delGCTinsCG 2 upstream_gene_variant 4338594 NA 0 0 0 5 64 2455 21914 0.00203252032520325 0.000660272864287742 0.00473679855039338 0.997087997087997 0.996282937561572 0.99775670266669 0.072463768115942 0.0239466209687045 0.161061740273612 NA NA NA 0 0 0.0560090893866365 NA NA NA NA 1665 1832 False True 0.697365071283095 0.218783496061652 1.71608724903713 0 0 0.00150147021965361 0.997087997087997 0.996282937561572 0.99775670266669 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 2 48 1109 7725 0.0018001800180018 0.000218084550259369 0.00648759665094944 0.993824778077962 0.991820795804122 0.99544347175401 0.04 0.00488143342616437 0.137137625603967 NA NA NA 0 0 0.0739727853472802 NA NA NA NA 910 981 False True 0 1 1 0 0 0 0 0.290238954012624 0.0341154842981315 1.10993474699743 0 0 0.00332078545526824 0.993824778077962 0.991820795804122 0.99544347175401 32 5) Not assoc w R New NotAwR yes 5 +Amikacin whiB6 c.-75_-74delGCinsT whiB6_c.-75_-74delGCinsT 2 upstream_gene_variant 4338595 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 13 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-75_-74insA whiB6_c.-75_-74insA 2 upstream_gene_variant 4338595 1 0 0 0 0 10 2460 21968 0 0 0.00149842073847528 0.999544999544999 0.999163397681526 0.999781788721324 0 0 0.30849710781876 NA NA NA 0 0 0.30849710781876 NA NA NA NA 1654 1832 False False 0 0 3.98680916993403 0 0 0.00149842073847528 0.999544999544999 0.999163397681526 0.999781788721324 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 907 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 6 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.75C>T whiB6_c.75C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin whiB6 c.-75delG whiB6_c.-75delG 2 upstream_gene_variant 4338595 NA 0 0 0 2397 21277 63 701 0.974390243902439 0.967351686849335 0.980265940585646 0.0318955318955318 0.0296116990075907 0.0343042404884564 0.101250316803244 0.0974356717261866 0.10516316467954 NA NA NA 0 0 0.0001733590118262 NA NA NA NA 1669 1832 False True 1.25353108767123 0.964020094968311 1.65477791152854 0 0 0.0568723523320162 0.0318955318955318 0.0296116990075907 0.0343042404884564 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 1092 7518 19 255 0.982898289828982 0.973421920882338 0.9896730546881 0.0328058664608259 0.0289576331943181 0.0370093869382521 0.126829268292682 0.119869130384282 0.134042989562064 NA NA NA 0 0 0.000490552618433523 NA NA NA NA 913 981 False True 0 1 1 0 0 0 0 1.94942663922375 1.21630956751258 3.30566543002268 0 0 0.176466911806965 0.0328058664608259 0.0289576331943181 0.0370093869382521 26837 5) Not assoc w R New NotAwR yes 5 +Amikacin whiB6 c.-75G>A whiB6_c.-75G>A 2 upstream_gene_variant 4338596 1 1 0 1 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 346.534733964433 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance No change no 1 +Amikacin whiB6 c.-75G>T whiB6_c.-75G>T 2 upstream_gene_variant 4338596 NA 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1650 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 903 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-76_-75delAG whiB6_c.-76_-75delAG 2 upstream_gene_variant 4338595 1 1 1 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.22908065008664 Inf 0.100662902037809 42.5 1832 False False Inf 0.22908065008664 Inf 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-76_-75delAGinsC whiB6_c.-76_-75delAGinsC 2 upstream_gene_variant 4338596 1 13 0 13 1 14 2459 21964 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999362999362999 0.998931451908832 0.999651703457902 0.0666666666666666 0.0016864302413527 0.319484566578303 0 0 0.24705263800047 0 0 0.231635761650116 0 0 2.93276040373482 0.633551203054086 135 1832 False False 0.638006158136292 0.0150856928331773 4.19687003176341 0 0 0.00149902964335061 0.999362999362999 0.998931451908832 0.999651703457902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 1 4 1110 7769 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.999485398173163 0.998682943858046 0.999859771090489 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 10.6140449193313 1 267 981 False False 0 0 0 0 0 0 0 1.74977477477477 0.0354986069371523 17.6959481769957 0 0 0.00331779872508707 0.999485398173163 0.998682943858046 0.999859771090489 23 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-76_-75delAGinsT whiB6_c.-76_-75delAGinsT 2 upstream_gene_variant 4338596 1 20 2 18 2 19 2458 21959 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.999135499135499 0.99865030256088 0.999479436294878 0.0952380952380952 0.0117493178844458 0.303774406913924 0.1 0.0123485271702948 0.316982714019082 0.0952380952380952 0.0117493178844458 0.303774406913924 0.99263176927945 0.111629340699048 4.15002860234111 1 662.5 1832 False False 0.940387991948953 0.106150439671543 3.90169428265347 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.999135499135499 0.99865030256088 0.999479436294878 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 0 9 1111 7764 0 0 0.00331481736263177 0.998842145889618 0.997803175208698 0.999470423012169 0 0 0.336267116879942 0 0 0.369416647552819 0 0 0.336267116879942 0 0 4.10007427033829 0.607127329949515 52 981 False False 0 0 0 0 0 0 0 0 0 3.54586915871032 0 0 0.00331481736263177 0.998842145889618 0.997803175208698 0.999470423012169 1 3) Uncertain significance No change no 1 +Amikacin whiB6 c.-76A>C whiB6_c.-76A>C 2 upstream_gene_variant 4338597 NA 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1689 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 927 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-76A>G whiB6_c.-76A>G 2 upstream_gene_variant 4338597 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1664 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Amikacin whiB6 c.-76delA whiB6_c.-76delA 2 upstream_gene_variant 4338596 1 4 0 4 0 6 2460 21972 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 0 0 0.4592581264399 0 0 0.602364635616474 0 0 0.4592581264399 0 0 13.5415294433897 1 165 1832 False False 0 0 7.5904311186467 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 271.670627328402 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 13 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-77_-75delGAGinsAA whiB6_c.-77_-75delGAGinsAA 2 upstream_gene_variant 4338596 1 3 0 3 1 5 2459 21973 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999772499772499 0.99946917089695 0.999926127301238 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.707598226178713 0 0 0.521823750104981 0 0 21.6327563455414 1 662.5 1832 False False 1.78714924766165 0.0377700438379967 15.9793065569956 0 0 0.00149902964335061 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 2 1110 7771 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.999742699086581 0.999070852951501 0.999968838146642 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 914 981 False False 0 0 0 0 0 0 0 3.50045045045045 0.0592795803100707 67.3732765257098 0 0 0.00331779872508707 0.999742699086581 0.999070852951501 0.999968838146642 17 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-77_-75delGAGinsCA whiB6_c.-77_-75delGAGinsCA 2 upstream_gene_variant 4338596 1 18 0 18 0 23 2460 21955 0 0 0.00149842073847528 0.998953498953498 0.998430145857126 0.999336496079682 0 0 0.148185128915224 0 0 0.185301968137852 0 0 0.148185128915224 0 0 2.03150947668974 0.247997781766041 80 1832 False False 0 0 1.55388439459048 0 0 0.00149842073847528 0.998953498953498 0.998430145857126 0.999336496079682 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 0 14 1111 7759 0 0 0.00331481736263177 0.998198893606072 0.996979894201843 0.999014979517878 0 0 0.231635761650116 0 0 0.30849710781876 0 0 0.231635761650116 0 0 3.1203165412864 0.624111596510178 61 981 False False 0 0 0 0 0 0 0 0 0 2.10898890968967 0 0 0.00331481736263177 0.998198893606072 0.996979894201843 0.999014979517878 23 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-77G>C whiB6_c.-77G>C 2 upstream_gene_variant 4338598 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1712 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-78_-75delAGAGinsCGA whiB6_c.-78_-75delAGAGinsCGA 2 upstream_gene_variant 4338596 1 26 2 24 5 36 2455 21942 0.00203252032520325 0.000660272864287742 0.00473679855039338 0.998361998361998 0.997733029382952 0.998852508231344 0.121951219512195 0.0408067262474272 0.262044675548309 0.0769230769230769 0.00945539100371274 0.251302916695373 0.0526315789473684 0.00643871671509191 0.17749059034764 0.744806517311609 0.0852652200157205 3.00301170023597 1 662.5 1832 False False 1.24134419551934 0.37987412893264 3.1778756641102 0.000814000814000814 9.85944813843771e-05 0.00293732612068725 0.998361998361998 0.997733029382952 0.998852508231344 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 1 6 1 12 1110 7761 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.99845619451949 0.997304837007313 0.999202046759043 0.0769230769230769 0.00194562849734675 0.360297435267877 0.142857142857142 0.00361029686190058 0.578723197043195 0.0769230769230769 0.00194562849734675 0.360297435267877 1.16531531531531 0.025311711373353 9.61868798358655 1 267 981 False False 0 0 0 0 0 0 0 0.582657657657657 0.0136211353314299 3.94507356448373 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.99845619451949 0.997304837007313 0.999202046759043 62 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-78_-75delAGAGinsGGA whiB6_c.-78_-75delAGAGinsGGA 2 upstream_gene_variant 4338596 1 3 0 3 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 21.6249500611508 1 662.5 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-78_-75delAGAGinsTGA whiB6_c.-78_-75delAGAGinsTGA 2 upstream_gene_variant 4338596 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 37.2625869115887 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 NA 3) Uncertain significance No change no 1 +Amikacin whiB6 c.-78A>C whiB6_c.-78A>C 2 upstream_gene_variant 4338599 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1666 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Amikacin whiB6 c.-78delA whiB6_c.-78delA 2 upstream_gene_variant 4338598 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1655 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-79_-78delTAinsC whiB6_c.-79_-78delTAinsC 2 upstream_gene_variant 4338599 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1661 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 909 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-79T>C whiB6_c.-79T>C 2 upstream_gene_variant 4338600 1 76 2 74 9 79 2451 21899 0.00365853658536585 0.00167423871507945 0.00693363251119005 0.996405496405496 0.995522160209872 0.997153195905483 0.102272727272727 0.0478429115537759 0.185286084643619 0.0263157894736842 0.00320300534473253 0.0918495233231658 0.0246913580246913 0.00300435151573275 0.0863628679458879 0.2414789330334 0.028694158217866 0.904694849002745 0.0325150011774574 19 1832 False False 1.0178795531661 0.448368780135604 2.03539100776063 0.000815328169588259 9.87552799446813e-05 0.00294211078923987 0.996405496405496 0.995522160209872 0.997153195905483 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 2 10 1109 7763 0.0018001800180018 0.000218084550259369 0.00648759665094944 0.998713495432908 0.997635349133423 0.999382904111848 0.166666666666666 0.0208625254600923 0.484137748685967 0 0 0.369416647552819 0 0 0.30849710781876 0 0 4.10695028723491 0.607127159223266 48 981 False False 0 0 0 0 0 0 0 1.4 0.148925476930613 6.58148515676435 0 0 0.00332078545526824 0.998713495432908 0.997635349133423 0.999382904111848 31 3) Uncertain significance No change no 1 +Amikacin whiB6 c.-79T>G whiB6_c.-79T>G 2 upstream_gene_variant 4338600 1 14 1 13 2 23 2458 21955 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.998953498953498 0.998430145857126 0.999336496079682 0.08 0.00983959001879751 0.260305842105214 0.0714285714285714 0.00180678065912538 0.338684489931821 0.0416666666666666 0.00105435244546974 0.211201683456973 0.687081429554985 0.0161609409768954 4.57815522379927 1 165 1832 False False 0.776700746453461 0.0887086124155599 3.14649104642921 0.000406669377795852 1.02959242167344e-05 0.0022637116293895 0.998953498953498 0.998430145857126 0.999336496079682 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 8 1111 7765 0 0 0.00331481736263177 0.998970796346327 0.997973071099689 0.99955556151365 0 0 0.369416647552819 0 0 0.4592581264399 0 0 0.369416647552819 0 0 5.94388498248289 1 267 981 False False 0 0 0 0 0 0 0 0 0 4.10060236216416 0 0 0.00331481736263177 0.998970796346327 0.997973071099689 0.99955556151365 20 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-80_-71delCTAGAGCTCG whiB6_c.-80_-71delCTAGAGCTCG 2 upstream_gene_variant 4338591 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-81_-74delACTAGAGC whiB6_c.-81_-74delACTAGAGC 2 upstream_gene_variant 4338594 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-81_-78delACTAinsTCC whiB6_c.-81_-78delACTAinsTCC 2 upstream_gene_variant 4338599 1 4 0 4 0 11 2460 21967 0 0 0.00149842073847528 0.999499499499499 0.999104643231992 0.999750126319878 0 0 0.284914152918154 0 0 0.602364635616474 0 0 0.284914152918154 0 0 13.5384405217834 1 662.5 1832 False False 0 0 3.56038548490505 0 0 0.00149842073847528 0.999499499499499 0.999104643231992 0.999750126319878 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 4 1111 7769 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 37.2530040824069 1 75.5 981 False False 0 0 0 0 0 0 0 0 0 10.6044836876068 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 4 3) Uncertain significance No change no 1 +Amikacin whiB6 c.-81_-80delAC whiB6_c.-81_-80delAC 2 upstream_gene_variant 4338600 1 3 0 3 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 21.6259333410942 1 662.5 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-81A>T whiB6_c.-81A>T 2 upstream_gene_variant 4338602 0 0 0 0 1 5 2459 21973 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999772499772499 0.99946917089695 0.999926127301238 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1713 1832 False False 1.78714924766165 0.0377700438379967 15.9793065569956 0 0 0.00149902964335061 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 942 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 5 3) Uncertain significance No change no 1 +Amikacin whiB6 c.81T>C whiB6_c.81T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin whiB6 c.-82_-27delCACTAGAGCTCGGAGCTCGCCGAACCGGAGCCGCAGCACCGCTAGGCAGGCAGAGG whiB6_c.-82_-27delCACTAGAGCTCGGAGCTCGCCGAACCGGAGCCGCAGCACCGCTAGGCAGGCAGAGG 2 upstream_gene_variant 4338547 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-82C>T whiB6_c.-82C>T 2 upstream_gene_variant 4338603 NA 0 0 0 31 1218 2429 20760 0.0126016260162601 0.00857781665357745 0.0178396739451486 0.944580944580944 0.941474056263298 0.947569582022197 0.0248198558847077 0.0169247613927233 0.0350459829637772 NA NA NA 0 0 0.00302405496841477 NA NA NA NA NA NA False True 0.217527535708708 0.146765514893671 0.311345872681668 0 0 0.00151752974619174 0.944580944580944 0.941474056263298 0.947569582022197 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 8 197 1103 7576 0.0072007200720072 0.00311373583188468 0.0141387520551147 0.974655860028303 0.970914504103818 0.978035259670226 0.0390243902439024 0.0169960495181607 0.0754429329759504 NA NA NA 0 0 0.0185510476173693 NA NA NA NA NA NA False True 1 1 1 0 0 1 0 0.278925496223957 0.118430610840563 0.562721419156384 0 0 0.00333881937479895 0.974655860028303 0.970914504103818 0.978035259670226 2981 Not assoc w R 5) Not assoc w R No change yes 1 +Amikacin whiB6 c.-84C>G whiB6_c.-84C>G 2 upstream_gene_variant 4338605 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-84C>T whiB6_c.-84C>T 2 upstream_gene_variant 4338605 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1718 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 c.-86C>T whiB6_c.-86C>T 2 upstream_gene_variant 4338607 1 0 0 0 0 9 2460 21969 0 0 0.00149842073847528 0.999590499590499 0.999222783640785 0.999812733785825 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1699 1832 False False 0 0 4.52743474605681 0 0 0.00149842073847528 0.999590499590499 0.999222783640785 0.999812733785825 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 7 1111 7766 0 0 0.00331481736263177 0.999099446803036 0.998145402056424 0.999637856686565 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 936 981 False False 0 0 0 0 0 0 0 0 0 4.85661817639599 0 0 0.00331481736263177 0.999099446803036 0.998145402056424 0.999637856686565 2 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.87C>T whiB6_c.87C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 2459 21977 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.9999544999545 0.999746516336938 0.999998848039248 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 8.93737291581943 0.113810496005924 697.318539256027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin whiB6 c.-87delG whiB6_c.-87delG 2 upstream_gene_variant 4338607 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1690 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 928 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-87G>A whiB6_c.-87G>A 2 upstream_gene_variant 4338608 NA 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1677 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 919 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-88delT whiB6_c.-88delT 2 upstream_gene_variant 4338608 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 c.-8T>G whiB6_c.-8T>G 2 upstream_gene_variant 4338529 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-91C>T whiB6_c.-91C>T 2 upstream_gene_variant 4338612 1 0 0 0 1 2 2459 21976 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999908999909 0.999671315452743 0.999988979276808 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1708 1832 False False 4.46848312322082 0.0757100934104112 86.0774363890598 0 0 0.00149902964335061 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 c.-93G>C whiB6_c.-93G>C 2 upstream_gene_variant 4338614 1 9 3 6 3 7 2457 21971 0.00121951219512195 0.00025156337591866 0.00355975660270706 0.999681499681499 0.999343878425726 0.999871937071415 0.3 0.0667395111777345 0.652452850059997 0.333333333333333 0.0748546314196918 0.700704943791459 0.3 0.0667395111777345 0.652452850059997 4.47110297110297 0.722980001218784 20.948431334515 0.0538363699800859 24 1832 False False 3.83237397523111 0.639014965217957 16.8035831416854 0.00121951219512195 0.00025156337591866 0.00355975660270706 0.999681499681499 0.999343878425726 0.999871937071415 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 37.2577954991549 1 267 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 13 3) Uncertain significance No change no 1 +Amikacin whiB6 c.-94C>T whiB6_c.-94C>T 2 upstream_gene_variant 4338615 1 1 0 1 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 346.534733964433 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 c.-96C>G whiB6_c.-96C>G 2 upstream_gene_variant 4338617 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Amikacin whiB6 c.96C>T whiB6_c.96C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin whiB6 c.-97_-95delACT whiB6_c.-97_-95delACT 2 upstream_gene_variant 4338615 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1704 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 c.-97A>C whiB6_c.-97A>C 2 upstream_gene_variant 4338618 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 c.-99_-98insCTGG whiB6_c.-99_-98insCTGG 2 upstream_gene_variant 4338619 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 c.-99G>T whiB6_c.-99G>T 2 upstream_gene_variant 4338620 1 3 0 3 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 21.6249500611508 1 662.5 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin whiB6 c.-9C>A whiB6_c.-9C>A 2 upstream_gene_variant 4338530 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 c.9C>T whiB6_c.9C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 7 53 2453 21925 0.00284552845528455 0.00114479164591456 0.00585403416056955 0.997588497588497 0.996846867371367 0.998193113358393 0.116666666666666 0.0482148418713419 0.225716153145648 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.18049519648639 0.452268884755454 2.60944385457818 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 32 1108 7741 0.0027002700270027 0.000557207149395569 0.00787087587058421 0.995883185385308 0.994193213278967 0.997182448944178 0.0857142857142857 0.0180376398142174 0.230575018658877 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.654980821299639 0.128126288606183 2.09919076469387 NA NA NA NA NA NA 36 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin whiB6 c.-9C>T whiB6_c.-9C>T 2 upstream_gene_variant 4338530 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1657 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 deletion whiB6_deletion 2 feature_ablation (see "Genomic_coordinates" sheet) 1 1 0 1 13 33 2447 21945 0.00528455284552845 0.00281671203821475 0.00901979289712418 0.998498498498498 0.997891973892477 0.998966217030968 0.282608695652173 0.159866701924902 0.43460407778425 0 0 0.975 0 0 0.105762810074579 0 0 347.877001282733 1 1139.5 1832 False False 3.53289742541888 1.70397480795461 6.90469487761016 0 0 0.00150637529121383 0.998498498498498 0.997891973892477 0.998966217030968 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 5 14 1106 7759 0.0045004500450045 0.00146284970071471 0.0104710615528963 0.998198893606072 0.996979894201843 0.999014979517878 0.263157894736842 0.0914657849076665 0.512029345345872 0 0 0.975 0 0 0.231635761650116 0 0 272.474002938488 1 267 981 False False 0 0 0 0 0 0 0 2.50548953758718 0.70477195340904 7.37903935182915 0 0 0.00332977799752235 0.998198893606072 0.996979894201843 0.999014979517878 39 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 LoF whiB6_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 189 6 183 41 336 2419 21642 0.0166666666666666 0.0119861508773179 0.0225428873255219 0.984711984711984 0.983001448782393 0.98629250759148 0.108753315649867 0.0791816918484699 0.144635255478136 0.0317460317460317 0.0117376245539098 0.0678140000697045 0.0175438596491228 0.00646481779915725 0.0377926270908455 0.293333514052006 0.106163353723513 0.65187526479655 0.000579602030726981 9 1832 False False 1.09170702179176 0.767214041696897 1.51752938027601 0.00247422680412371 0.000908522017018378 0.0053775146160553 0.984711984711984 0.983001448782393 0.98629250759148 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 54 0 54 15 99 1096 7674 0.0135013501350135 0.00757576336173372 0.0221707867273702 0.987263604785797 0.984515416272351 0.989636761446342 0.131578947368421 0.0755527711343679 0.207718795341368 0 0 0.0660315142444217 0 0 0.0365757449834789 0 0 0.496015422077694 0.00136350834081395 6 981 False False 0 0 0 0 0 0 0 1.06088254810882 0.570113218071926 1.8439867133437 0 0 0.00336010808459033 0.987263604785797 0.984515416272351 0.989636761446342 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Ala14Gly whiB6_p.Ala14Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Ala25Pro whiB6_p.Ala25Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1685 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Ala25Ser whiB6_p.Ala25Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1679 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Ala49Asp whiB6_p.Ala49Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 21.6259333410942 1 662.5 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Ala49Val whiB6_p.Ala49Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Ala4Val whiB6_p.Ala4Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Ala55Asp whiB6_p.Ala55Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 21.6259333410942 1 662.5 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Ala55Pro whiB6_p.Ala55Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1659 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Ala63fs whiB6_p.Ala63fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Ala63Glu whiB6_p.Ala63Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 2460 21973 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 9.75275991328737 1 662.5 1832 False False 0 0 9.75275991328737 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Ala63Thr whiB6_p.Ala63Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 2460 21972 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 7.5904311186467 1 662.5 1832 False False 0 0 7.5904311186467 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 1111 7768 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 7.63947436138835 1 75.5 981 False False 0 0 0 0 0 0 0 0 0 7.63947436138835 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 1 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Ala63Val whiB6_p.Ala63Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 21.6259333410942 1 662.5 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Ala66Thr whiB6_p.Ala66Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 16 0 16 13 24 2447 21954 0.00528455284552845 0.00281671203821475 0.00901979289712418 0.998907998907998 0.998375621827042 0.999300212912473 0.351351351351351 0.202099815284002 0.525388744373974 0 0 0.205907214207822 0 0 0.142473597722525 0 0 2.32811479352272 0.396121819290539 95 1832 False False 4.85972619534123 2.26908292117349 9.94513031767312 0 0 0.00150637529121383 0.998907998907998 0.998375621827042 0.999300212912473 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 13 0 13 12 15 1099 7758 0.0108010801080108 0.0055931822251036 0.0187912331484252 0.998070243149363 0.996819153789367 0.998919540064859 0.444444444444444 0.254798806631737 0.646735769677994 0 0 0.24705263800047 0 0 0.218019360910534 0 0 2.32007354851161 0.39086009394177 40 981 False False 0 0 0 0 0 0 0 5.64731574158325 2.40600298688986 12.956315630617 0 0 0.00335095120015557 0.998070243149363 0.996819153789367 0.998919540064859 37 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Ala66Val whiB6_p.Ala66Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 2460 21972 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 7.5904311186467 1 662.5 1832 False False 0 0 7.5904311186467 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 6 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Ala6Glu whiB6_p.Ala6Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Ala6Ser whiB6_p.Ala6Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Ala72fs whiB6_p.Ala72fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 33 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Ala72Glu whiB6_p.Ala72Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 1 5 1 5 2459 21973 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999772499772499 0.99946917089695 0.999926127301238 0.166666666666666 0.00421074451448947 0.641234578997674 0.166666666666666 0.00421074451448947 0.641234578997674 0.166666666666666 0.00421074451448947 0.641234578997674 1.78714924766165 0.0377700438379967 15.9793065569956 0.470939656427458 104.5 1832 False False 1.78714924766165 0.0377700438379967 15.9793065569956 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 16.9345443329059 1 267 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 1 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Ala72Gly whiB6_p.Ala72Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 2 4 2458 21974 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.999817999817999 0.999534073414941 0.999950408920832 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.707598226178713 0 0 0.602364635616474 0 0 21.6425371884495 1 662.5 1832 False False 4.46989422294548 0.404101568721157 31.1808198790316 0 0 0.00149963904330158 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 2 3 1109 7770 0.0018001800180018 0.000218084550259369 0.00648759665094944 0.999614048629872 0.998872504682436 0.999920400475616 0.4 0.0527449505263169 0.853367200365326 0 0 0.841886116991581 0 0 0.707598226178713 0 0 37.3249731495879 1 75.5 981 False False 0 0 0 0 0 0 0 4.67087466185752 0.389614743310331 40.8502933343974 0 0 0.00332078545526824 0.999614048629872 0.998872504682436 0.999920400475616 3 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Ala72Val whiB6_p.Ala72Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Ala77fs whiB6_p.Ala77fs 2 frameshift (see "Genomic_coordinates" sheet) 1 4 0 4 1 4 2459 21974 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999817999817999 0.999534073414941 0.999950408920832 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 13.5482881491524 1 662.5 1832 False False 2.23403822692151 0.045345258756558 22.5860023464291 0 0 0.00149902964335061 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 1110 7771 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.999742699086581 0.999070852951501 0.999968838146642 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 37.2961498596314 1 267 981 False False 0 0 0 0 0 0 0 3.50045045045045 0.0592795803100707 67.3732765257098 0 0 0.00331779872508707 0.999742699086581 0.999070852951501 0.999968838146642 4 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Ala77Glu whiB6_p.Ala77Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 2460 21973 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 13.5421472279808 1 662.5 1832 False False 0 0 9.75275991328737 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 271.670627328402 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 2 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Ala77Ser whiB6_p.Ala77Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 10 0 10 0 11 2460 21967 0 0 0.00149842073847528 0.999499499499499 0.999104643231992 0.999750126319878 0 0 0.284914152918154 0 0 0.30849710781876 0 0 0.284914152918154 0 0 3.98662760843631 0.612510233731959 125 1832 False False 0 0 3.56038548490505 0 0 0.00149842073847528 0.999499499499499 0.999104643231992 0.999750126319878 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 1111 7768 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 7.63947436138835 1 75.5 981 False False 0 0 0 0 0 0 0 0 0 7.63947436138835 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 1 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Ala77Val whiB6_p.Ala77Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 131 4 127 9 132 2451 21846 0.00365853658536585 0.00167423871507945 0.00693363251119005 0.993993993993994 0.992881623035694 0.994972469980546 0.0638297872340425 0.0295998373908749 0.117709761292875 0.0305343511450381 0.008381012720474 0.0763343078286475 0.0294117647058823 0.00807068500725258 0.0735926987357061 0.280727454967761 0.0752907045371058 0.73762905305391 0.00498503291575025 14 1832 False False 0.607711138310893 0.27152812467373 1.19117526036709 0.00162932790224032 0.000444109836370163 0.00416642601550677 0.993993993993994 0.992881623035694 0.994972469980546 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 30 0 30 1 30 1110 7743 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.996140486298726 0.994494851870603 0.997394533107523 0.032258064516129 0.000816370071846613 0.167021116230227 0 0 0.115703308222027 0 0 0.115703308222027 0 0 0.914393010391792 0.0270081544635338 10 981 False False 0 0 0 0 0 0 0 0.232522522522522 0.00569771591856196 1.40178063856493 0 0 0.00331779872508707 0.996140486298726 0.994494851870603 0.997394533107523 26 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Ala87Val whiB6_p.Ala87Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 346.534733964433 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 920 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 2 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Ala89fs whiB6_p.Ala89fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Ala89Glu whiB6_p.Ala89Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Ala91Glu whiB6_p.Ala91Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 47.551166952306 1 165 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 941 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Ala91Gly whiB6_p.Ala91Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Ala91Thr whiB6_p.Ala91Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Ala91Val whiB6_p.Ala91Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 7 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Ala99fs whiB6_p.Ala99fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Ala99Val whiB6_p.Ala99Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 18 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Ala9Ser whiB6_p.Ala9Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Arg101Cys whiB6_p.Arg101Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 21.6249500611508 1 662.5 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 925 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 7 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Arg107Cys whiB6_p.Arg107Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 7 370 2453 21608 0.00284552845528455 0.00114479164591456 0.00585403416056955 0.983164983164983 0.981375995346947 0.984824480766384 0.0185676392572944 0.00749693707014662 0.0378806951716317 NA NA NA 0 0 0.00992040933174687 NA NA NA NA NA NA False True 0.16665307786384 0.0664887070262594 0.347407209656902 0 0 0.00150269349036671 0.983164983164983 0.981375995346947 0.984824480766384 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 2 68 1109 7705 0.0018001800180018 0.000218084550259369 0.00648759665094944 0.991251768943779 0.98892253815033 0.993200435299511 0.0285714285714285 0.00347905707104214 0.0994289300921684 NA NA NA 0 0 0.0528030427936397 NA NA NA NA NA NA False True 1 1 1 0 0 1 0 0.204344136211743 0.0242164851940729 0.769100926087624 0 0 0.00332078545526824 0.991251768943779 0.98892253815033 0.993200435299511 457 Not assoc w R 5) Not assoc w R No change yes 1 +Amikacin whiB6 p.Arg107fs whiB6_p.Arg107fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 2459 21977 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.9999544999545 0.999746516336938 0.999998848039248 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 346.690584657338 1 662.5 1832 False False 8.93737291581943 0.113810496005924 697.318539256027 0 0 0.00149902964335061 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Arg107Pro whiB6_p.Arg107Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1702 1832 False False Inf 0.22908065008664 Inf 0 0 0.00149902964335061 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Arg110Trp whiB6_p.Arg110Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 10 0 10 0 10 2460 21968 0 0 0.00149842073847528 0.999544999544999 0.999163397681526 0.999781788721324 0 0 0.30849710781876 0 0 0.30849710781876 0 0 0.30849710781876 0 0 3.98680916993403 0.612510116809134 123 1832 False False 0 0 3.98680916993403 0 0 0.00149842073847528 0.999544999544999 0.999163397681526 0.999781788721324 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 37.2625869115887 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 4 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Arg17fs whiB6_p.Arg17fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1667 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Arg17Gly whiB6_p.Arg17Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 9 1 8 3 20 2457 21958 0.00121951219512195 0.00025156337591866 0.00355975660270706 0.999089999089999 0.998594925555303 0.999444061992291 0.130434782608695 0.0277515074227932 0.335889137537121 0.111111111111111 0.00280913674659921 0.482496514917337 0.0476190476190476 0.00120488344836351 0.238159909936821 1.11711436711436 0.0251655904712964 8.33830815570041 1 662.5 1832 False False 1.34053724053724 0.254904957407483 4.52417707928455 0.000406834825061025 1.03001129356897e-05 0.00226463172978561 0.999089999089999 0.998594925555303 0.999444061992291 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 1 6 1110 7767 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.999228097259745 0.998320655545558 0.999716674296114 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.521823750104981 0 0 0.4592581264399 0 0 7.64537951547685 1 267 981 False False 0 0 0 0 0 0 0 1.16621621621621 0.0253312798003414 9.6261228731741 0 0 0.00331779872508707 0.999228097259745 0.998320655545558 0.999716674296114 11 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Arg17Lys whiB6_p.Arg17Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 10 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Arg17Ser whiB6_p.Arg17Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 11 0 11 0 11 2460 21967 0 0 0.00149842073847528 0.999499499499499 0.999104643231992 0.999750126319878 0 0 0.284914152918154 0 0 0.284914152918154 0 0 0.284914152918154 0 0 3.56038548490505 0.616667685925898 131.5 1832 False False 0 0 3.56038548490505 0 0 0.00149842073847528 0.999499499499499 0.999104643231992 0.999750126319878 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 6 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Arg2fs whiB6_p.Arg2fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance New Uncertain no 1 +Amikacin whiB6 p.Arg40Cys whiB6_p.Arg40Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 7 2460 21971 0 0 0.00149842073847528 0.999681499681499 0.999343878425726 0.999871937071415 0 0 0.409616397225003 0 0 0.521823750104981 0 0 0.409616397225003 0 0 9.75187230990876 1 662.5 1832 False False 0 0 6.20059597931892 0 0 0.00149842073847528 0.999681499681499 0.999343878425726 0.999871937071415 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 271.670627328402 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 2 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Arg40His whiB6_p.Arg40His 2 missense_variant (see "Genomic_coordinates" sheet) 1 13 0 13 0 14 2460 21964 0 0 0.00149842073847528 0.999362999362999 0.998931451908832 0.999651703457902 0 0 0.231635761650116 0 0 0.24705263800047 0 0 0.231635761650116 0 0 2.9315680573594 0.633597202329469 136.5 1832 False False 0 0 2.69356616691972 0 0 0.00149842073847528 0.999362999362999 0.998931451908832 0.999651703457902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 271.670627328402 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 12 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Arg54fs whiB6_p.Arg54fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1658 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Arg54Gln whiB6_p.Arg54Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 112 2457 21866 0.00121951219512195 0.00025156337591866 0.00355975660270706 0.994903994903995 0.993871360216222 0.995802169612967 0.0260869565217391 0.00541240902789704 0.0743462344101988 NA NA NA 0 0 0.0323999259313598 NA NA NA NA NA NA False True 0.238378684807256 0.0484006928491923 0.715690201836798 0 0 0.00150024893893223 0.994903994903995 0.993871360216222 0.995802169612967 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 51 1111 7722 0 0 0.00331481736263177 0.993438826707834 0.991382186240657 0.995110987683495 0 0 0.0697770307495386 NA NA NA 0 0 0.0697770307495386 NA NA NA NA NA NA False True 1 1 1 0 0 1 0 0 0 0.522364284418383 0 0 0.00331481736263177 0.993438826707834 0.991382186240657 0.995110987683495 873 Not assoc w R 5) Not assoc w R No change yes 1 +Amikacin whiB6 p.Arg54Gly whiB6_p.Arg54Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 5 2459 21973 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999772499772499 0.99946917089695 0.999926127301238 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.975 0 0 0.521823750104981 0 0 346.627828649019 1 662.5 1832 False False 1.78714924766165 0.0377700438379967 15.9793065569956 0 0 0.00149902964335061 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Arg54Pro whiB6_p.Arg54Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 8 2460 21970 0 0 0.00149842073847528 0.999635999635999 0.999282900840091 0.999842837798826 0 0 0.369416647552819 0 0 0.602364635616474 0 0 0.369416647552819 0 0 13.5402938744772 1 662.5 1832 False False 0 0 5.2353912865109 0 0 0.00149842073847528 0.999635999635999 0.999282900840091 0.999842837798826 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Arg54Trp whiB6_p.Arg54Trp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1698 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Arg58Cys whiB6_p.Arg58Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Arg58fs whiB6_p.Arg58fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Arg58Gly whiB6_p.Arg58Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Arg58Leu whiB6_p.Arg58Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1709 1832 False False Inf 0.22908065008664 Inf 0 0 0.00149902964335061 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Arg58Pro whiB6_p.Arg58Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Arg59Gln whiB6_p.Arg59Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1719 1832 False False Inf 0.22908065008664 Inf 0 0 0.00149902964335061 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Arg59Leu whiB6_p.Arg59Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Arg59Pro whiB6_p.Arg59Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1693 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Arg59Trp whiB6_p.Arg59Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 1 7 1 8 2459 21970 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999635999635999 0.999282900840091 0.999842837798826 0.111111111111111 0.00280913674659921 0.482496514917337 0.125 0.0031597235312519 0.526509670875206 0.111111111111111 0.00280913674659921 0.482496514917337 1.27636089002498 0.0283087155985394 9.94190395459242 0.572133344853712 112 1832 False False 1.11681577877185 0.0251588722809246 8.33607459248682 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999635999635999 0.999282900840091 0.999842837798826 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 2 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Arg64fs whiB6_p.Arg64fs 2 frameshift (see "Genomic_coordinates" sheet) 1 6 0 6 0 7 2460 21971 0 0 0.00149842073847528 0.999681499681499 0.999343878425726 0.999871937071415 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 7.59008565309221 1 662.5 1832 False False 0 0 6.20059597931892 0 0 0.00149842073847528 0.999681499681499 0.999343878425726 0.999871937071415 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 37.2625869115887 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 2 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Arg64Leu whiB6_p.Arg64Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 3 2459 21975 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.9998634998635 0.999601141012814 0.999971849505602 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 47.5704345304069 1 662.5 1832 False False 2.97885319235461 0.0567200675769732 37.1234870649317 0 0 0.00149902964335061 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Arg86fs whiB6_p.Arg86fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 47.551166952306 1 165 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 908 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 4 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Arg86Gln whiB6_p.Arg86Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Arg86Pro whiB6_p.Arg86Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Arg86Trp whiB6_p.Arg86Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 3 2459 21975 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.9998634998635 0.999601141012814 0.999971849505602 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 47.5704345304069 1 662.5 1832 False False 2.97885319235461 0.0567200675769732 37.1234870649317 0 0 0.00149902964335061 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Arg88fs whiB6_p.Arg88fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.22908065008664 Inf 0.100662902037809 42.5 1832 False False Inf 0.22908065008664 Inf 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Arg88Gly whiB6_p.Arg88Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Arg88Trp whiB6_p.Arg88Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 1 14 2459 21964 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999362999362999 0.998931451908832 0.999651703457902 0.0666666666666666 0.0016864302413527 0.319484566578303 0 0 0.369416647552819 0 0 0.231635761650116 0 0 5.23609135149481 1 662.5 1832 False False 0.638006158136292 0.0150856928331773 4.19687003176341 0 0 0.00149902964335061 0.999362999362999 0.998931451908832 0.999651703457902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 7 1110 7766 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.999099446803036 0.998145402056424 0.999637856686565 0.125 0.0031597235312519 0.526509670875206 0 0 0.707598226178713 0 0 0.409616397225003 0 0 16.9410396837164 1 267 981 False False 0 0 0 0 0 0 0 0.999485199485199 0.0221570004013934 7.79164585701028 0 0 0.00331779872508707 0.999099446803036 0.998145402056424 0.999637856686565 27 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Arg96* whiB6_p.Arg96* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 1 6 2459 21972 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999726999726999 0.999405888764937 0.999899807333004 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1686 1832 False False 1.48922326148841 0.0323630859858146 12.2827873722144 0 0 0.00149902964335061 0.999726999726999 0.999405888764937 0.999899807333004 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 1110 7772 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.99987134954329 0.999283416286792 0.999996742857744 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 926 981 False False 0 0 0 0 0 0 0 7.0018018018018 0.0891187877143753 547.10724479397 0 0 0.00331779872508707 0.99987134954329 0.999283416286792 0.999996742857744 6 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Asn102Asp whiB6_p.Asn102Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 2460 21972 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 7.5904311186467 1 662.5 1832 False False 0 0 7.5904311186467 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 16.9345443329059 1 267 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 7 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Asn102fs whiB6_p.Asn102fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1681 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Asn13Ser whiB6_p.Asn13Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Asn18Thr whiB6_p.Asn18Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Asp108fs whiB6_p.Asp108fs 2 frameshift (see "Genomic_coordinates" sheet) 1 4 0 4 5 5 2455 21973 0.00203252032520325 0.000660272864287742 0.00473679855039338 0.999772499772499 0.99946917089695 0.999926127301238 0.5 0.187086028447398 0.812913971552601 0 0 0.602364635616474 0 0 0.521823750104981 0 0 13.5698067306604 1 662.5 1832 False False 8.95030549898167 2.05793513005316 38.8853277655382 0 0 0.00150147021965361 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 1110 7771 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.999742699086581 0.999070852951501 0.999968838146642 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 271.914335788577 1 267 981 False False 0 0 0 0 0 0 0 3.50045045045045 0.0592795803100707 67.3732765257098 0 0 0.00331779872508707 0.999742699086581 0.999070852951501 0.999968838146642 2 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Asp20Ala whiB6_p.Asp20Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Asp37Gly whiB6_p.Asp37Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 1 8 2459 21970 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999635999635999 0.999282900840091 0.999842837798826 0.111111111111111 0.00280913674659921 0.482496514917337 0 0 0.369416647552819 0 0 0.369416647552819 0 0 5.23752174793822 1 662.5 1832 False False 1.11681577877185 0.0251588722809246 8.33607459248682 0 0 0.00149902964335061 0.999635999635999 0.999282900840091 0.999842837798826 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Asp37His whiB6_p.Asp37His 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Asp39fs whiB6_p.Asp39fs 2 frameshift (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 21.6259333410942 1 662.5 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 7 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Asp46Ala whiB6_p.Asp46Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 5 2460 21973 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 0 0 0.521823750104981 0 0 0.841886116991581 0 0 0.521823750104981 0 0 47.5468558639646 1 662.5 1832 False False 0 0 9.75275991328737 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 904 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 4 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Asp46fs whiB6_p.Asp46fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Asp46Glu whiB6_p.Asp46Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 4 2459 21974 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999817999817999 0.999534073414941 0.999950408920832 0.2 0.00505076337946806 0.716417936118089 0 0 0.707598226178713 0 0 0.602364635616474 0 0 21.6337400291578 1 662.5 1832 False False 2.23403822692151 0.045345258756558 22.5860023464291 0 0 0.00149902964335061 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Asp46Gly whiB6_p.Asp46Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 13.5427650126618 1 662.5 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Asp46His whiB6_p.Asp46His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 2 2458 21976 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.999908999909 0.999671315452743 0.999988979276808 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 346.815170796598 1 662.5 1832 False False 8.94060211554109 0.647679042113151 123.448658884577 0 0 0.00149963904330158 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1110 7773 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 1 0.999525536566873 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 935 981 False False 0 0 0 0 0 0 0 Inf 0.179394825906045 Inf 0 0 0.00331779872508707 1 0.999525536566873 1 NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Asp47fs whiB6_p.Asp47fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Asp47Gly whiB6_p.Asp47Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 2460 21973 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 13.5421472279808 1 662.5 1832 False False 0 0 9.75275991328737 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Asp65Ala whiB6_p.Asp65Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1668 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 911 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Asp65fs whiB6_p.Asp65fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Asp65Gly whiB6_p.Asp65Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1662 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Cys12Ser whiB6_p.Cys12Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 1 4 2 4 2458 21974 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.999817999817999 0.999534073414941 0.999950408920832 0.333333333333333 0.0432718682927417 0.777221904496487 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 2.23494711147274 0.0453636993803864 22.5951949425765 0.411588009091805 101 1832 False False 4.46989422294548 0.404101568721157 31.1808198790316 0.000406669377795852 1.02959242167344e-05 0.0022637116293895 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 1 4 1110 7769 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.999485398173163 0.998682943858046 0.999859771090489 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 10.6140449193313 1 267 981 False False 0 0 0 0 0 0 0 1.74977477477477 0.0354986069371523 17.6959481769957 0 0 0.00331779872508707 0.999485398173163 0.998682943858046 0.999859771090489 10 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Cys34Tyr whiB6_p.Cys34Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 13.5427650126618 1 662.5 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Cys53Arg whiB6_p.Cys53Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 30 1 29 6 38 2454 21940 0.0024390243902439 0.000895588528695574 0.00530111511191433 0.998270998270998 0.997627574582383 0.998776173913035 0.136363636363636 0.0517308294862734 0.273506890903823 0.0333333333333333 0.000843570926630479 0.172169455633412 0.0256410256410256 0.000648963895481945 0.134763921559497 0.308293286119776 0.00754846304655338 1.86118296000204 0.359209851849903 89 1832 False False 1.41165873118002 0.487197829053274 3.3703689939376 0.000407331975560081 1.0312699566839799e-05 0.00226739652422111 0.998270998270998 0.997627574582383 0.998776173913035 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 19 0 19 0 21 1111 7752 0 0 0.00331481736263177 0.997298340409108 0.995873175693845 0.998326876273275 0 0 0.161097615219079 0 0 0.176466911806965 0 0 0.161097615219079 0 0 1.4977462663079 0.157752824945606 33 981 False False 0 0 0 0 0 0 0 0 0 1.34232399703266 0 0 0.00331481736263177 0.997298340409108 0.995873175693845 0.998326876273275 81 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Cys53fs whiB6_p.Cys53fs 2 frameshift (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 13.5427650126618 1 662.5 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 37.2625869115887 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Cys53Gly whiB6_p.Cys53Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 32 0 32 1 35 2459 21943 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.998407498407498 0.997785905018943 0.998890521362752 0.0277777777777777 0.00070302520590478 0.145289264746853 0 0 0.108881160679352 0 0 0.100032435572105 0 0 1.09120154196011 0.0703277919282312 28 1832 False False 0.254958461627839 0.00627865319887974 1.51835624633129 0 0 0.00149902964335061 0.998407498407498 0.997785905018943 0.998890521362752 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 0 11 1111 7762 0 0 0.00331481736263177 0.998584844976199 0.99746931080593 0.99929335470516 0 0 0.284914152918154 0 0 0.30849710781876 0 0 0.284914152918154 0 0 3.12152162291275 0.624075152593875 59 981 False False 0 0 0 0 0 0 0 0 0 2.78806716438789 0 0 0.00331481736263177 0.998584844976199 0.99746931080593 0.99929335470516 27 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Cys53Phe whiB6_p.Cys53Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 346.534733964433 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Cys53Ser whiB6_p.Cys53Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1672 1832 False False Inf 0.22908065008664 Inf 0 0 0.00149902964335061 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1110 7773 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 1 0.999525536566873 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 916 981 False False 0 0 0 0 0 0 0 Inf 0.179394825906045 Inf 0 0 0.00331779872508707 1 0.999525536566873 1 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Cys53* whiB6_p.Cys53* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1671 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 915 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Cys53Trp whiB6_p.Cys53Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 2460 21972 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 7.5904311186467 1 662.5 1832 False False 0 0 7.5904311186467 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 16.9345443329059 1 267 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 10 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Cys53Tyr whiB6_p.Cys53Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Cys56fs whiB6_p.Cys56fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 2459 21977 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.9999544999545 0.999746516336938 0.999998848039248 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 8.93737291581943 0.113810496005924 697.318539256027 0.191196488852352 72.5 1832 False False 8.93737291581943 0.113810496005924 697.318539256027 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Cys56Gly whiB6_p.Cys56Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1652 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Cys56Tyr whiB6_p.Cys56Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1705 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Cys62Arg whiB6_p.Cys62Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1697 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 934 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Cys62fs whiB6_p.Cys62fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Cys62Gly whiB6_p.Cys62Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1651 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 905 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Cys62Ser whiB6_p.Cys62Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Cys62Tyr whiB6_p.Cys62Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 2459 21977 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.9999544999545 0.999746516336938 0.999998848039248 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 8.93737291581943 0.113810496005924 697.318539256027 0.191196488852352 72.5 1832 False False 8.93737291581943 0.113810496005924 697.318539256027 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Gln114fs whiB6_p.Gln114fs 2 frameshift (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 21.6259333410942 1 662.5 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 37.2625869115887 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 2 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Gln36* whiB6_p.Gln36* 2 stop_gained (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 21.6249500611508 1 662.5 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 37.2625869115887 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 3 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Gln94Glu whiB6_p.Gln94Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 226 4 222 4 259 2456 21719 0.0016260162601626 0.000443206823318481 0.00415796841630328 0.988215488215488 0.986699610819912 0.989600090906734 0.0152091254752851 0.00415911842117562 0.0384813936109698 0.0176991150442477 0.00484294246017614 0.0446942616064804 0.0152091254752851 0.00415911842117562 0.0384813936109698 0.159337676438653 0.0430003481345273 0.414322564465448 1.15488917196436e-06 5 1832 True False 0.136575151233131 0.0368991190131561 0.354422253930663 0.0016260162601626 0.000443206823318481 0.00415796841630328 0.988215488215488 0.986699610819912 0.989600090906734 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 0 9 1111 7764 0 0 0.00331481736263177 0.998842145889618 0.997803175208698 0.999470423012169 0 0 0.336267116879942 0 0 0.369416647552819 0 0 0.336267116879942 0 0 4.10007427033829 0.607127329949515 52 981 False False 0 0 0 0 0 0 0 0 0 3.54586915871032 0 0 0.00331481736263177 0.998842145889618 0.997803175208698 0.999470423012169 638 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Gln94* whiB6_p.Gln94* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 2459 21976 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999908999909 0.999671315452743 0.999988979276808 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 346.674895666859 1 165 1832 False False 4.46848312322082 0.0757100934104112 86.0774363890598 0 0 0.00149902964335061 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1110 7773 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 1 0.999525536566873 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 912 981 False False 0 0 0 0 0 0 0 Inf 0.179394825906045 Inf 0 0 0.00331779872508707 1 0.999525536566873 1 1 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Glu100fs whiB6_p.Glu100fs 2 frameshift (see "Genomic_coordinates" sheet) 1 10 0 10 0 12 2460 21966 0 0 0.00149842073847528 0.999453999453999 0.999046441372309 0.999717842739244 0 0 0.264648469397051 0 0 0.30849710781876 0 0 0.264648469397051 0 0 3.98644604698276 0.612510351386665 127 1832 False False 0 0 3.21614145803178 0 0 0.00149842073847528 0.999453999453999 0.999046441372309 0.999717842739244 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 20 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Glu100* whiB6_p.Glu100* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Glu28fs whiB6_p.Glu28fs 2 frameshift (see "Genomic_coordinates" sheet) 1 15 0 15 0 18 2460 21960 0 0 0.00149842073847528 0.999180999180999 0.998705933279372 0.999514538264563 0 0 0.185301968137852 0 0 0.218019360910534 0 0 0.185301968137852 0 0 2.49066487458649 0.390111454831693 93.5 1832 False False 0 0 2.03197230182158 0 0 0.00149842073847528 0.999180999180999 0.998705933279372 0.999514538264563 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 0 9 1111 7764 0 0 0.00331481736263177 0.998842145889618 0.997803175208698 0.999470423012169 0 0 0.336267116879942 0 0 0.369416647552819 0 0 0.336267116879942 0 0 4.10007427033829 0.607127329949515 52 981 False False 0 0 0 0 0 0 0 0 0 3.54586915871032 0 0 0.00331481736263177 0.998842145889618 0.997803175208698 0.999470423012169 15 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Glu28Gln whiB6_p.Glu28Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 2460 21973 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 13.5421472279808 1 662.5 1832 False False 0 0 9.75275991328737 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Glu28Lys whiB6_p.Glu28Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 6 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Glu48_Thr51delinsAla whiB6_p.Glu48_Thr51delinsAla 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Glu48fs whiB6_p.Glu48fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Glu73fs whiB6_p.Glu73fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Glu73* whiB6_p.Glu73* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Glu83* whiB6_p.Glu83* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1710 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Glu8Ala whiB6_p.Glu8Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Glu8Asp whiB6_p.Glu8Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 0 10 2460 21968 0 0 0.00149842073847528 0.999544999544999 0.999163397681526 0.999781788721324 0 0 0.30849710781876 0 0 0.369416647552819 0 0 0.30849710781876 0 0 5.23491468175418 1 662.5 1832 False False 0 0 3.98680916993403 0 0 0.00149842073847528 0.999544999544999 0.999163397681526 0.999781788721324 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 1111 7768 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 7.63947436138835 1 75.5 981 False False 0 0 0 0 0 0 0 0 0 7.63947436138835 0 0 0.00331481736263177 0.999356747716454 0.998499507558406 0.999791105797204 35 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Glu8fs whiB6_p.Glu8fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Glu8Gly whiB6_p.Glu8Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 9 2460 21969 0 0 0.00149842073847528 0.999590499590499 0.999222783640785 0.999812733785825 0 0 0.336267116879942 0 0 0.521823750104981 0 0 0.336267116879942 0 0 9.75098470649694 1 662.5 1832 False False 0 0 4.52743474605681 0 0 0.00149842073847528 0.999590499590499 0.999222783640785 0.999812733785825 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Glu8Lys whiB6_p.Glu8Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 9 2460 21969 0 0 0.00149842073847528 0.999590499590499 0.999222783640785 0.999812733785825 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1687 1832 False False 0 0 4.52743474605681 0 0 0.00149842073847528 0.999590499590499 0.999222783640785 0.999812733785825 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 26 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Glu8Val whiB6_p.Glu8Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Gly32Ser whiB6_p.Gly32Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Gly74Arg whiB6_p.Gly74Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 2 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Gly74Glu whiB6_p.Gly74Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1670 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Gly78fs whiB6_p.Gly78fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Gly78Val whiB6_p.Gly78Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 21.6249500611508 1 662.5 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Gly85Ala whiB6_p.Gly85Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Gly85Arg whiB6_p.Gly85Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Gly85Asp whiB6_p.Gly85Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 8 2460 21970 0 0 0.00149842073847528 0.999635999635999 0.999282900840091 0.999842837798826 0 0 0.369416647552819 0 0 0.841886116991581 0 0 0.369416647552819 0 0 47.5403892135865 1 165 1832 False False 0 0 5.2353912865109 0 0 0.00149842073847528 0.999635999635999 0.999282900840091 0.999842837798826 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 2 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Gly85fs whiB6_p.Gly85fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 2 7 2458 21971 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.999681499681499 0.999343878425726 0.999871937071415 0.222222222222222 0.0281449734778982 0.600093573716312 0 0 0.975 0 0 0.409616397225003 0 0 346.736694159855 1 662.5 1832 False False 2.55387655469022 0.2587089419725 13.4183971176954 0 0 0.00149963904330158 0.999681499681499 0.999343878425726 0.999871937071415 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 6 1109 7767 0.0018001800180018 0.000218084550259369 0.00648759665094944 0.999228097259745 0.998320655545558 0.999716674296114 0.25 0.0318540262499442 0.650855794412824 0 0 0.975 0 0 0.4592581264399 0 0 272.019005962343 1 75.5 981 False False 0 0 0 0 0 0 0 2.33453561767357 0.230129967394223 13.0724908825586 0 0 0.00332078545526824 0.999228097259745 0.998320655545558 0.999716674296114 1 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Gly85Ser whiB6_p.Gly85Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 13 0 13 0 15 2460 21963 0 0 0.00149842073847528 0.999317499317499 0.998874568358369 0.999617960830416 0 0 0.218019360910534 0 0 0.24705263800047 0 0 0.218019360910534 0 0 2.93143466242526 0.633602351267789 138 1832 False False 0 0 2.49100508208792 0 0 0.00149842073847528 0.999317499317499 0.998874568358369 0.999617960830416 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 1111 7769 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 16.9323809419784 1 267 981 False False 0 0 0 0 0 0 0 0 0 10.6044836876068 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 49 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Gly85Val whiB6_p.Gly85Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Gly93Asp whiB6_p.Gly93Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Gly93fs whiB6_p.Gly93fs 2 frameshift (see "Genomic_coordinates" sheet) 1 6 0 6 0 7 2460 21971 0 0 0.00149842073847528 0.999681499681499 0.999343878425726 0.999871937071415 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 7.59008565309221 1 662.5 1832 False False 0 0 6.20059597931892 0 0 0.00149842073847528 0.999681499681499 0.999343878425726 0.999871937071415 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 11 3) Uncertain significance No change no 1 +Amikacin whiB6 p.His109fs whiB6_p.His109fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin whiB6 p.His109Tyr whiB6_p.His109Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Leu26fs whiB6_p.Leu26fs 2 frameshift (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 2460 21972 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 7.5904311186467 1 662.5 1832 False False 0 0 7.5904311186467 0 0 0.00149842073847528 0.999726999726999 0.999405888764937 0.999899807333004 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 4 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Leu31fs whiB6_p.Leu31fs 2 frameshift (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 13.5427650126618 1 662.5 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 37.2625869115887 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 5 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Leu52fs whiB6_p.Leu52fs 2 frameshift (see "Genomic_coordinates" sheet) 1 6 0 6 0 7 2460 21971 0 0 0.00149842073847528 0.999681499681499 0.999343878425726 0.999871937071415 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 7.59008565309221 1 662.5 1832 False False 0 0 6.20059597931892 0 0 0.00149842073847528 0.999681499681499 0.999343878425726 0.999871937071415 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Leu52Gln whiB6_p.Leu52Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 15 0 15 0 18 2460 21960 0 0 0.00149842073847528 0.999180999180999 0.998705933279372 0.999514538264563 0 0 0.185301968137852 0 0 0.218019360910534 0 0 0.185301968137852 0 0 2.49066487458649 0.390111454831693 93.5 1832 False False 0 0 2.03197230182158 0 0 0.00149842073847528 0.999180999180999 0.998705933279372 0.999514538264563 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 0 8 1111 7765 0 0 0.00331481736263177 0.998970796346327 0.997973071099689 0.99955556151365 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 4.10060236216416 0.607127307172024 49 981 False False 0 0 0 0 0 0 0 0 0 4.10060236216416 0 0 0.00331481736263177 0.998970796346327 0.997973071099689 0.99955556151365 20 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Leu52Pro whiB6_p.Leu52Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Leu52* whiB6_p.Leu52* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Leu61fs whiB6_p.Leu61fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1673 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Leu75fs whiB6_p.Leu75fs 2 frameshift (see "Genomic_coordinates" sheet) 1 3 1 2 1 3 2459 21975 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.9998634998635 0.999601141012814 0.999971849505602 0.25 0.00630946320970987 0.805879550316756 0.333333333333333 0.00840375865961264 0.905700675949754 0.25 0.00630946320970987 0.805879550316756 4.46827978853192 0.0757066482836372 86.0735556013939 0.27262965691207 85 1832 False False 2.97885319235461 0.0567200675769732 37.1234870649317 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Leu75Gln whiB6_p.Leu75Gln 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 4 2458 21974 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.999817999817999 0.999534073414941 0.999950408920832 0.333333333333333 0.0432718682927417 0.777221904496487 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1682 1832 False False 4.46989422294548 0.404101568721157 31.1808198790316 0 0 0.00149963904330158 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 3 1109 7770 0.0018001800180018 0.000218084550259369 0.00648759665094944 0.999614048629872 0.998872504682436 0.999920400475616 0.4 0.0527449505263169 0.853367200365326 NA NA NA 0 0 0.707598226178713 NA NA NA NA 923 981 False False 0 0 0 0 0 0 0 4.67087466185752 0.389614743310331 40.8502933343974 0 0 0.00332078545526824 0.999614048629872 0.998872504682436 0.999920400475616 24 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Leu92fs whiB6_p.Leu92fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Leu92Ser whiB6_p.Leu92Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 2 1 17 1 2443 21977 0.00691056910569105 0.00403066294102424 0.0110415047085623 0.9999544999545 0.999746516336938 0.999998848039248 0.944444444444444 0.727056400326631 0.99859444383263 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 17.9918133442488 0.936076644661787 1053.4499048701 0.0280508759440742 17 1832 False False 152.930413426115 23.9292634344892 6135.25456270631 0.000817995910020449 9.90784557008057e-05 0.00295172704220955 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Leu95Ala whiB6_p.Leu95Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1674 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 917 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Leu95Arg whiB6_p.Leu95Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 4 7 2456 21971 0.0016260162601626 0.000443206823318481 0.00415796841630328 0.999681499681499 0.999343878425726 0.999871937071415 0.363636363636363 0.109263443819098 0.692095284988322 0 0 0.707598226178713 0 0 0.409616397225003 0 0 21.6571984232612 1 662.5 1832 False False 5.11191251744997 1.09646093464027 20.1216719292516 0 0 0.00150085933084757 0.999681499681499 0.999343878425726 0.999871937071415 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 4 1111 7769 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 271.601013915947 1 75.5 981 False False 0 0 0 0 0 0 0 0 0 10.6044836876068 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 3 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Leu95del whiB6_p.Leu95del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Leu95Pro whiB6_p.Leu95Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 346.534733964433 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 944 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 4 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Leu95Val whiB6_p.Leu95Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Leu98Arg whiB6_p.Leu98Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 21.6259333410942 1 662.5 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Leu98fs whiB6_p.Leu98fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 23 2460 21955 0 0 0.00149842073847528 0.998953498953498 0.998430145857126 0.999336496079682 0 0 0.148185128915224 0 0 0.841886116991581 0 0 0.148185128915224 0 0 47.5080556403382 1 165 1832 False False 0 0 1.55388439459048 0 0 0.00149842073847528 0.998953498953498 0.998430145857126 0.999336496079682 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 16 1111 7757 0 0 0.00331481736263177 0.997941592692654 0.996659422164099 0.998822998929686 0 0 0.205907214207822 NA NA NA 0 0 0.205907214207822 NA NA NA NA 932 981 False False 0 0 0 0 0 0 0 0 0 1.81358991296359 0 0 0.00331481736263177 0.997941592692654 0.996659422164099 0.998822998929686 3 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Leu98Pro whiB6_p.Leu98Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 2458 21977 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.9999544999545 0.999746516336938 0.999998848039248 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 346.830866100726 1 165 1832 False False 17.8820179007323 0.930367849464557 1047.07427525324 0 0 0.00149963904330158 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 1110 7772 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.99987134954329 0.999283416286792 0.999996742857744 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 271.949173528644 1 75.5 981 False False 0 0 0 0 0 0 0 7.0018018018018 0.0891187877143753 547.10724479397 0 0 0.00331779872508707 0.99987134954329 0.999283416286792 0.999996742857744 2 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Leu98Val whiB6_p.Leu98Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Lys50Asn whiB6_p.Lys50Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 4 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Lys50Gln whiB6_p.Lys50Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Lys50Glu whiB6_p.Lys50Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Lys50* whiB6_p.Lys50* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Met1? whiB6_p.Met1? 2 start_lost (see "Genomic_coordinates" sheet) 1 5 0 5 1 55 2459 21923 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.997497497497497 0.996743878846489 0.998114233222622 0.0178571428571428 0.000452001530520825 0.0955259026323396 0 0 0.521823750104981 0 0 0.0648707608254246 0 0 9.73452854592991 1 662.5 1832 False False 0.162098413989426 0.00403352630696788 0.942519519971303 0 0 0.00149902964335061 0.997497497497497 0.996743878846489 0.998114233222622 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 7 1111 7766 0 0 0.00331481736263177 0.999099446803036 0.998145402056424 0.999637856686565 0 0 0.409616397225003 0 0 0.707598226178713 0 0 0.409616397225003 0 0 16.9258908082757 1 75.5 981 False False 0 0 0 0 0 0 0 0 0 4.85661817639599 0 0 0.00331481736263177 0.999099446803036 0.998145402056424 0.999637856686565 241 3) Uncertain significance New Uncertain no 1 +Amikacin whiB6 p.Met21_Asp46del whiB6_p.Met21_Asp46del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Met21Ile whiB6_p.Met21Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 6 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Met21Thr whiB6_p.Met21Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 1 19 2459 21959 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999135499135499 0.99865030256088 0.999479436294878 0.05 0.0012650894979498 0.248732762772027 0 0 0.521823750104981 0 0 0.176466911806965 0 0 9.75051191341383 1 662.5 1832 False False 0.47000278247469 0.0113101019019507 2.95921387480553 0 0 0.00149902964335061 0.999135499135499 0.99865030256088 0.999479436294878 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Phe5Cys whiB6_p.Phe5Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1688 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Phe5Ser whiB6_p.Phe5Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Phe90Leu whiB6_p.Phe90Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 2459 21976 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999908999909 0.999671315452743 0.999988979276808 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 346.674895666859 1 165 1832 False False 4.46848312322082 0.0757100934104112 86.0774363890598 0 0 0.00149902964335061 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Phe90Ser whiB6_p.Phe90Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 2459 21975 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.9998634998635 0.999601141012814 0.999971849505602 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 21.6347237132381 1 165 1832 False False 2.97885319235461 0.0567200675769732 37.1234870649317 0 0 0.00149902964335061 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 1110 7772 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.99987134954329 0.999283416286792 0.999996742857744 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 271.949173528644 1 75.5 981 False False 0 0 0 0 0 0 0 7.0018018018018 0.0891187877143753 547.10724479397 0 0 0.00331779872508707 0.99987134954329 0.999283416286792 0.999996742857744 3 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Phe90Val whiB6_p.Phe90Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 2459 21977 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.9999544999545 0.999746516336938 0.999998848039248 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 8.93737291581943 0.113810496005924 697.318539256027 0.191196488852352 72.5 1832 False False 8.93737291581943 0.113810496005924 697.318539256027 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Pro105fs whiB6_p.Pro105fs 2 frameshift (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 21.6249500611508 1 662.5 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 2 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Pro105Gln whiB6_p.Pro105Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 21.6249500611508 1 662.5 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 10 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Pro30Leu whiB6_p.Pro30Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1706 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 939 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Pro38Ala whiB6_p.Pro38Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 25 2 23 9 25 2451 21953 0.00365853658536585 0.00167423871507945 0.00693363251119005 0.998862498862498 0.99832127875239 0.999263738201867 0.264705882352941 0.128817391583508 0.443615368305106 0.08 0.00983959001879751 0.260305842105214 0.074074074074074 0.00910007294230628 0.242898346845627 0.778848030085324 0.0889537248750864 3.15521272521241 1 662.5 1832 False False 3.22443084455324 1.322720563131 7.15082584055102 0.000815328169588259 9.87552799446813e-05 0.00294211078923987 0.998862498862498 0.99832127875239 0.999263738201867 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 1 7 2 8 1109 7765 0.0018001800180018 0.000218084550259369 0.00648759665094944 0.998970796346327 0.997973071099689 0.99955556151365 0.2 0.0252107263268333 0.556095462307641 0.125 0.0031597235312519 0.526509670875206 0.111111111111111 0.00280913674659921 0.482496514917337 1.00025763235862 0.0221741062909341 7.79767671909421 1 267 981 False False 0 0 0 0 0 0 0 1.75045085662759 0.180836667613198 8.78708905307725 0.0009009009009009 2.28085759023601e-05 0.00500917409467553 0.998970796346327 0.997973071099689 0.99955556151365 5 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Pro38fs whiB6_p.Pro38fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.22908065008664 Inf 0.100662902037809 42.5 1832 False False Inf 0.22908065008664 Inf 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Pro38Leu whiB6_p.Pro38Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 41 4 37 9 40 2451 21938 0.00365853658536585 0.00167423871507945 0.00693363251119005 0.998179998179998 0.997522490030905 0.998699455493482 0.183673469387755 0.0875903353128472 0.320221214428868 0.0975609756097561 0.0272274667983608 0.231314549309461 0.0909090909090909 0.0253284217034507 0.216686589465274 0.967635934588199 0.250313629060013 2.69678016698187 1 662.5 1832 False False 2.01389228886168 0.858175077074587 4.22263152876814 0.00162932790224032 0.000444109836370163 0.00416642601550677 0.998179998179998 0.997522490030905 0.998699455493482 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 921 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 19 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Pro38Ser whiB6_p.Pro38Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 13.5427650126618 1 662.5 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 2 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Pro45Ser whiB6_p.Pro45Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Pro57Leu whiB6_p.Pro57Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 9 0 9 0 10 2460 21968 0 0 0.00149842073847528 0.999544999544999 0.999163397681526 0.999781788721324 0 0 0.30849710781876 0 0 0.336267116879942 0 0 0.30849710781876 0 0 4.52722867409844 0.612224497730614 117 1832 False False 0 0 3.98680916993403 0 0 0.00149842073847528 0.999544999544999 0.999163397681526 0.999781788721324 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Pro82Leu whiB6_p.Pro82Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 21.6259333410942 1 662.5 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 37.2625869115887 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 2 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Ser112fs whiB6_p.Ser112fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1660 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Ser112Phe whiB6_p.Ser112Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Ser115Ala whiB6_p.Ser115Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 10 2460 21968 0 0 0.00149842073847528 0.999544999544999 0.999163397681526 0.999781788721324 0 0 0.30849710781876 0 0 0.409616397225003 0 0 0.30849710781876 0 0 6.19974925881069 1 165 1832 False False 0 0 3.98680916993403 0 0 0.00149842073847528 0.999544999544999 0.999163397681526 0.999781788721324 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 929 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 7 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Ser115fs whiB6_p.Ser115fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 2459 21977 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.9999544999545 0.999746516336938 0.999998848039248 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 8.93737291581943 0.113810496005924 697.318539256027 0.191196488852352 72.5 1832 False False 8.93737291581943 0.113810496005924 697.318539256027 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Ser69Pro whiB6_p.Ser69Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Ser84fs whiB6_p.Ser84fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Ser84Leu whiB6_p.Ser84Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Ser97fs whiB6_p.Ser97fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.22908065008664 Inf 0.100662902037809 42.5 1832 False False Inf 0.22908065008664 Inf 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Ser97Pro whiB6_p.Ser97Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 26 0 26 1 28 2459 21950 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.998725998725998 0.998159235769423 0.999153273664351 0.0344827586206896 0.000872646883579922 0.177644295488722 0 0 0.132274604497754 0 0 0.123436118500263 0 0 1.36182120320197 0.104189912802464 57 1832 False False 0.318799744379248 0.0077964281908789 1.93007678271173 0 0 0.00149902964335061 0.998725998725998 0.998159235769423 0.999153273664351 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 1 7 1110 7766 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.999099446803036 0.998145402056424 0.999637856686565 0.125 0.0031597235312519 0.526509670875206 0 0 0.409616397225003 0 0 0.409616397225003 0 0 4.86099858540905 0.607152438969844 54 981 False False 0 0 0 0 0 0 0 0.999485199485199 0.0221570004013934 7.79164585701028 0 0 0.00331779872508707 0.999099446803036 0.998145402056424 0.999637856686565 10 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Ter117Trpext*? whiB6_p.Ter117Trpext*? 2 stop_lost (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Thr10Ala whiB6_p.Thr10Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Thr11Ala whiB6_p.Thr11Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1649 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Thr11Pro whiB6_p.Thr11Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Thr24Ala whiB6_p.Thr24Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1680 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Thr24fs whiB6_p.Thr24fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 2459 21977 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.9999544999545 0.999746516336938 0.999998848039248 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 346.690584657338 1 662.5 1832 False False 8.93737291581943 0.113810496005924 697.318539256027 0 0 0.00149902964335061 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1110 7773 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 1 0.999525536566873 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 922 981 False False 0 0 0 0 0 0 0 Inf 0.179394825906045 Inf 0 0 0.00331779872508707 1 0.999525536566873 1 1 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Thr35Met whiB6_p.Thr35Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Thr35Pro whiB6_p.Thr35Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Thr42Ala whiB6_p.Thr42Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Thr42Met whiB6_p.Thr42Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 47.551166952306 1 165 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Thr43Ala whiB6_p.Thr43Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1716 1832 False False Inf 0.22908065008664 Inf 0 0 0.00149902964335061 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Thr43Pro whiB6_p.Thr43Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Thr44del whiB6_p.Thr44del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Thr44fs whiB6_p.Thr44fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Thr44Ile whiB6_p.Thr44Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 346.519051274799 1 662.5 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Thr44Pro whiB6_p.Thr44Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 24 2460 21954 0 0 0.00149842073847528 0.998907998907998 0.998375621827042 0.999300212912473 0 0 0.142473597722525 0 0 0.975 0 0 0.142473597722525 0 0 346.189713007368 1 662.5 1832 False False 0 0 1.48391022109741 0 0 0.00149842073847528 0.998907998907998 0.998375621827042 0.999300212912473 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 271.635820641185 1 75.5 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 6 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Thr51fs whiB6_p.Thr51fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1717 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Thr51Pro whiB6_p.Thr51Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 321 930 2139 21048 0.130487804878048 0.117419565254659 0.144442488845736 0.957684957684957 0.954939585702079 0.960308430560921 0.256594724220623 0.232587910618301 0.281750946226321 NA NA NA 0 0 0.00395868073025034 NA NA NA NA NA NA False True 3.3964258245487 2.95943280660572 3.89042849369023 0 0 0.00172309508909921 0.957684957684957 0.954939585702079 0.960308430560921 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 216 655 895 7118 0.194419441944194 0.171532020443432 0.218937307906888 0.915733950855525 0.909337163253897 0.921816941319144 0.247990815154994 0.219629922206186 0.278067673980522 NA NA NA 0 0 0.00561604773989051 NA NA NA NA NA NA False True 0 1 1 0 0 1 0 2.62269265213868 2.20428593328002 3.11185045912437 0 0 0.00411317066731714 0.915733950855525 0.909337163253897 0.921816941319144 691 Not assoc w R 5) Not assoc w R No change yes 1 +Amikacin whiB6 p.Trp16Arg whiB6_p.Trp16Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Trp16Cys whiB6_p.Trp16Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 13.5427650126618 1 662.5 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 37.2625869115887 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 2 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Trp16Ser whiB6_p.Trp16Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 2 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Trp16* whiB6_p.Trp16* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Trp41Cys whiB6_p.Trp41Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 3 2459 21975 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.9998634998635 0.999601141012814 0.999971849505602 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 47.5704345304069 1 662.5 1832 False False 2.97885319235461 0.0567200675769732 37.1234870649317 0 0 0.00149902964335061 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Trp41fs whiB6_p.Trp41fs 2 frameshift (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 21.6259333410942 1 662.5 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 16.9345443329059 1 267 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 1 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Trp41Ser whiB6_p.Trp41Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Trp41* whiB6_p.Trp41* 2 stop_gained (see "Genomic_coordinates" sheet) 1 6 0 6 1 9 2459 21969 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999590499590499 0.999222783640785 0.999812733785825 0.1 0.00252857854446178 0.445016117028195 0 0 0.4592581264399 0 0 0.336267116879942 0 0 7.59248289544654 1 662.5 1832 False False 0.992679951199674 0.0226387633018841 7.16949857929758 0 0 0.00149902964335061 0.999590499590499 0.999222783640785 0.999812733785825 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Trp60Arg whiB6_p.Trp60Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Trp60fs whiB6_p.Trp60fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Trp60Ser whiB6_p.Trp60Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 21.6259333410942 1 662.5 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Trp60* whiB6_p.Trp60* 2 stop_gained (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 2460 21973 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 13.5421472279808 1 662.5 1832 False False 0 0 9.75275991328737 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Trp76Arg whiB6_p.Trp76Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 2459 21977 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.9999544999545 0.999746516336938 0.999998848039248 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 8.93737291581943 0.113810496005924 697.318539256027 0.191196488852352 72.5 1832 False False 8.93737291581943 0.113810496005924 697.318539256027 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1110 7773 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 1 0.999525536566873 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.179394825906045 Inf 0.125056280954525 25.5 981 False False 0 0 0 0 0 0 0 Inf 0.179394825906045 Inf 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 1 0.999525536566873 1 6 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Trp76Cys whiB6_p.Trp76Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Trp76Gly whiB6_p.Trp76Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 5 2459 21973 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999772499772499 0.99946917089695 0.999926127301238 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.841886116991581 0 0 0.521823750104981 0 0 47.5661217312038 1 662.5 1832 False False 1.78714924766165 0.0377700438379967 15.9793065569956 0 0 0.00149902964335061 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 271.670627328402 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 2 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Trp76Ser whiB6_p.Trp76Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Trp76* whiB6_p.Trp76* 2 stop_gained (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 21.6249500611508 1 662.5 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 271.670627328402 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 1 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Tyr104fs whiB6_p.Tyr104fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 2457 21978 0.00121951219512195 0.00025156337591866 0.00355975660270706 1 0.99983216990204 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1691 1832 False False Inf 3.69364604813985 Inf 0 0 0.00150024893893223 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 1109 7773 0.0018001800180018 0.000218084550259369 0.00648759665094944 1 0.999525536566873 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 930 981 False False 0 0 0 0 0 0 0 Inf 1.31458832505494 Inf 0 0 0.00332078545526824 1 0.999525536566873 1 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Tyr104His whiB6_p.Tyr104His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Tyr27fs whiB6_p.Tyr27fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Tyr27Ser whiB6_p.Tyr27Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1700 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 937 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 2 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Tyr27* whiB6_p.Tyr27* 2 stop_gained (see "Genomic_coordinates" sheet) 1 17 0 17 0 23 2460 21955 0 0 0.00149842073847528 0.998953498953498 0.998430145857126 0.999336496079682 0 0 0.148185128915224 0 0 0.195064322969093 0 0 0.148185128915224 0 0 2.1642995913621 0.405895705674599 100 1832 False False 0 0 1.55388439459048 0 0 0.00149842073847528 0.998953498953498 0.998430145857126 0.999336496079682 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 1111 7769 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 16.9323809419784 1 267 981 False False 0 0 0 0 0 0 0 0 0 10.6044836876068 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 37 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Tyr3Cys whiB6_p.Tyr3Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 10 0 10 0 11 2460 21967 0 0 0.00149842073847528 0.999499499499499 0.999104643231992 0.999750126319878 0 0 0.284914152918154 0 0 0.30849710781876 0 0 0.284914152918154 0 0 3.98662760843631 0.612510233731959 125 1832 False False 0 0 3.56038548490505 0 0 0.00149842073847528 0.999499499499499 0.999104643231992 0.999750126319878 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 6 1111 7767 0 0 0.00331481736263177 0.999228097259745 0.998320655545558 0.999716674296114 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 7.63849110700196 1 267 981 False False 0 0 0 0 0 0 0 0 0 5.94541565066903 0 0 0.00331481736263177 0.999228097259745 0.998320655545558 0.999716674296114 4 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Tyr3Ser whiB6_p.Tyr3Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1675 1832 False False Inf 0.22908065008664 Inf 0 0 0.00149902964335061 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Val106fs whiB6_p.Val106fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Val111Ala whiB6_p.Val111Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Val111fs whiB6_p.Val111fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1695 1832 False False Inf 0.22908065008664 Inf 0 0 0.00149902964335061 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Val23Ala whiB6_p.Val23Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Val23Gly whiB6_p.Val23Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 21 2460 21957 0 0 0.00149842073847528 0.999044499044499 0.998539784170517 0.999408435614546 0 0 0.161097615219079 NA NA NA 0 0 0.161097615219079 NA NA NA NA 1676 1832 False False 0 0 1.71532634382271 0 0 0.00149842073847528 0.999044499044499 0.998539784170517 0.999408435614546 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 918 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 3 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Val33Asp whiB6_p.Val33Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Val33Gly whiB6_p.Val33Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 5 2460 21973 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1696 1832 False False 0 0 9.75275991328737 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1111 7769 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 933 981 False False 0 0 0 0 0 0 0 0 0 10.6044836876068 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 6 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Val67fs whiB6_p.Val67fs 2 frameshift (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 21.6249500611508 1 662.5 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Val79Ala whiB6_p.Val79Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 16 0 16 0 17 2460 21961 0 0 0.00149842073847528 0.999226499226499 0.99876183824676 0.999549344777619 0 0 0.195064322969093 0 0 0.205907214207822 0 0 0.195064322969093 0 0 2.31654237123084 0.396577483441142 98 1832 False False 0 0 2.16489187000965 0 0 0.00149842073847528 0.999226499226499 0.99876183824676 0.999549344777619 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 0 10 1111 7763 0 0 0.00331481736263177 0.998713495432908 0.997635349133423 0.999382904111848 0 0 0.30849710781876 0 0 0.30849710781876 0 0 0.30849710781876 0 0 3.12192331569373 0.624063020601868 58 981 False False 0 0 0 0 0 0 0 0 0 3.12192331569373 0 0 0.00331481736263177 0.998713495432908 0.997635349133423 0.999382904111848 1 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Val79fs whiB6_p.Val79fs 2 frameshift (see "Genomic_coordinates" sheet) 1 20 0 20 4 28 2456 21950 0.0016260162601626 0.000443206823318481 0.00415796841630328 0.998725998725998 0.998159235769423 0.999153273664351 0.125 0.0351306531033114 0.289948420190755 0 0 0.168433470983085 0 0 0.123436118500263 0 0 1.81169084884721 0.254847932738135 82 1832 False False 1.27675663099115 0.325140455966952 3.65367153083822 0 0 0.00150085933084757 0.998725998725998 0.998159235769423 0.999153273664351 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 1 5 1110 7768 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.999356747716454 0.998499507558406 0.999791105797204 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.521823750104981 0 0 0.521823750104981 0 0 7.64636365642647 1 267 981 False False 0 0 0 0 0 0 0 1.39963963963963 0.0295658812501739 12.524223051576 0 0 0.00331779872508707 0.999356747716454 0.998499507558406 0.999791105797204 23 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Val79Gly whiB6_p.Val79Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 9 0 9 0 10 2460 21968 0 0 0.00149842073847528 0.999544999544999 0.999163397681526 0.999781788721324 0 0 0.30849710781876 0 0 0.336267116879942 0 0 0.30849710781876 0 0 4.52722867409844 0.612224497730614 117 1832 False False 0 0 3.98680916993403 0 0 0.00149842073847528 0.999544999544999 0.999163397681526 0.999781788721324 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 16.9345443329059 1 267 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 11 3) Uncertain significance No change no 1 +Amikacin whiB6 p.Val80fs whiB6_p.Val80fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance New Uncertain no 0 +Amikacin whiB6 p.Val80Gly whiB6_p.Val80Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1711 1832 False False Inf 0.22908065008664 Inf 0 0 0.00149902964335061 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB7 c.-100T>C whiB7_c.-100T>C 1 upstream_gene_variant 3568779 1 277 3 274 7 292 2453 21686 0.00284552845528455 0.00114479164591456 0.00585403416056955 0.986713986713986 0.98511143171654 0.988185823776618 0.0234113712374581 0.00946321595728632 0.0476393853818019 0.0108303249097472 0.00223906653102727 0.0313228046228238 0.0101694915254237 0.0021021237556159 0.0294302951206828 0.096794927111447 0.0198214917471933 0.286245818737591 2.01206284805299e-09 NA NA False True 0.211932271917529 0.0843649929989173 0.442981205198025 0.0012214983713355 0.000251973203554902 0.00356554744375924 0.986713986713986 0.98511143171654 0.988185823776618 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 78 0 78 0 86 1111 7687 0 0 0.00331481736263177 0.988936060723015 0.986353919907177 0.991141015489785 0 0 0.0419870153041445 0 0 0.0461924203280487 0 0 0.0419870153041445 0 0 0.335741095602972 4.44691947635535e-05 NA NA False True 1 1 1 0 0 1 0 0 0 0.30382197999206 0 0 0.00331481736263177 0.988936060723015 0.986353919907177 0.991141015489785 134 Not assoc w R 5) Not assoc w R No change yes 1 +Amikacin whiB7 c.-103G>C whiB7_c.-103G>C 1 upstream_gene_variant 3568782 0 0 0 0 3 4 2457 21974 0.00121951219512195 0.00025156337591866 0.00355975660270706 0.999817999817999 0.999534073414941 0.999950408920832 0.428571428571428 0.0989882784425078 0.815948432359917 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1159 1832 False False 6.7075702075702 0.981840926473112 39.6690812973678 0 0 0.00150024893893223 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 1 1108 7772 0.0027002700270027 0.000557207149395569 0.00787087587058421 0.99987134954329 0.999283416286792 0.999996742857744 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 459 981 False False 0 0 0 0 0 0 0 21.0433212996389 1.68688212270013 1097.05743060038 0 0 0.00332377756768462 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB7 c.105T>C whiB7_c.105T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin whiB7 c.-106A>G whiB7_c.-106A>G 1 upstream_gene_variant 3568785 0 0 0 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1153 1832 False False Inf 0.22908065008664 Inf 0 0 0.00149902964335061 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1110 7773 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 1 0.999525536566873 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 454 981 False False 0 0 0 0 0 0 0 Inf 0.179394825906045 Inf 0 0 0.00331779872508707 1 0.999525536566873 1 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB7 c.-115C>G whiB7_c.-115C>G 1 upstream_gene_variant 3568794 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1154 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 455 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB7 c.-116A>G whiB7_c.-116A>G 1 upstream_gene_variant 3568795 1 135 6 129 33 144 2427 21834 0.0134146341463414 0.00925152524791068 0.0187879663536337 0.993447993447993 0.992290703722112 0.994471694290316 0.186440677966101 0.131949230636363 0.251745786580723 0.0444444444444444 0.0164825365151952 0.0942258783756563 0.04 0.014818521114898 0.0850278147181987 0.418432172938166 0.150592599547154 0.937334818621019 0.0296846302097244 18 1832 False False 2.06165018541409 1.36419866156881 3.0347400944058 0.00246609124537607 0.000905532965762571 0.0053598583626311 0.993447993447993 0.992290703722112 0.994471694290316 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 60 4 56 17 59 1094 7714 0.0153015301530153 0.00893830679574086 0.0243865047834515 0.992409623054161 0.990219751905789 0.994216977087357 0.223684210526315 0.136036399878925 0.333804509093885 0.0666666666666666 0.0184617775758815 0.161986755197728 0.0634920634920634 0.0175687932633545 0.154660677395377 0.503656307129798 0.132373371938915 1.36712009515101 0.236412842274409 34 981 False False 0 0 0 0 0 0 0 2.03169832367613 1.1058740551791 3.54823756731792 0.00364298724954462 0.000993456093882753 0.00930101177117559 0.992409623054161 0.990219751905789 0.994216977087357 29 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-121C>T whiB7_c.-121C>T 1 upstream_gene_variant 3568800 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-124G>A whiB7_c.-124G>A 1 upstream_gene_variant 3568803 1 1 0 1 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 346.534733964433 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-128A>G whiB7_c.-128A>G 1 upstream_gene_variant 3568807 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1169 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-139C>A whiB7_c.-139C>A 1 upstream_gene_variant 3568818 1 3 0 3 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 21.6259333410942 1 662.5 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 37.2625869115887 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 NA 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-140C>G whiB7_c.-140C>G 1 upstream_gene_variant 3568819 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-151T>A whiB7_c.-151T>A 1 upstream_gene_variant 3568830 1 3 0 3 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 21.6259333410942 1 662.5 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-154C>T whiB7_c.-154C>T 1 upstream_gene_variant 3568833 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 3 3) Uncertain significance No change no 1 +Amikacin whiB7 c.15A>C whiB7_c.15A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin whiB7 c.-161A>G whiB7_c.-161A>G 1 upstream_gene_variant 3568840 1 6 1 5 1 5 2459 21973 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999772499772499 0.99946917089695 0.999926127301238 0.166666666666666 0.00421074451448947 0.641234578997674 0.166666666666666 0.00421074451448947 0.641234578997674 0.166666666666666 0.00421074451448947 0.641234578997674 1.78714924766165 0.0377700438379967 15.9793065569956 0.470939656427458 104.5 1832 False False 1.78714924766165 0.0377700438379967 15.9793065569956 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 16.9345443329059 1 267 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 5 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-163C>G whiB7_c.-163C>G 1 upstream_gene_variant 3568842 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-166delG whiB7_c.-166delG 1 upstream_gene_variant 3568844 1 5 0 5 0 5 2460 21973 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 9.75275991328737 1 662.5 1832 False False 0 0 9.75275991328737 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1111 7770 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 16.9345443329059 1 267 981 False False 0 0 0 0 0 0 0 0 0 16.9345443329059 0 0 0.00331481736263177 0.999614048629872 0.998872504682436 0.999920400475616 1 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-166G>A whiB7_c.-166G>A 1 upstream_gene_variant 3568845 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-176delG whiB7_c.-176delG 1 upstream_gene_variant 3568854 1 4 0 4 24 106 2436 21872 0.00975609756097561 0.00626063537842125 0.0144817247141775 0.995176995176995 0.994169663687377 0.996049679965179 0.184615384615384 0.122014594750123 0.262123920748271 0 0 0.602364635616474 0 0 0.0342021672763502 0 0 13.6129376812735 1 662.5 1832 False False 2.03290268612324 1.24520365835293 3.19657956030916 0 0 0.0015131723294567 0.995176995176995 0.994169663687377 0.996049679965179 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 5 19 1106 7754 0.0045004500450045 0.00146284970071471 0.0104710615528963 0.997555641322526 0.996185451564254 0.998527714753364 0.208333333333333 0.0713186171980549 0.421512843637252 NA NA NA 0 0 0.176466911806965 NA NA NA NA 457 981 False False 0 0 0 0 0 0 0 1.84496050252212 0.537262130910658 5.12098877928385 0 0 0.00332977799752235 0.997555641322526 0.996185451564254 0.998527714753364 34 3) Uncertain significance No change no 1 +Amikacin whiB7 c.177G>T whiB7_c.177G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 37.2625869115887 NA NA NA NA NA NA 207 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin whiB7 c.-178C>T whiB7_c.-178C>T 1 upstream_gene_variant 3568857 1 83 1 82 2 113 2458 21865 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.994858494858494 0.99382171009534 0.995760849883871 0.017391304347826 0.00211315082226153 0.0614123325587228 0.0120481927710843 0.000304987313046937 0.0653083735513444 0.0087719298245614 0.000222061375671979 0.0479052578523625 0.10848101768243 0.00271649170155834 0.622206545405311 0.0028486282384736 NA NA False True 0.15744147699043 0.0188367171110691 0.582717919495498 0.000406669377795852 1.02959242167344e-05 0.0022637116293895 0.994858494858494 0.99382171009534 0.995760849883871 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 7 0 7 0 18 1111 7755 0 0 0.00331481736263177 0.997684291779235 0.996342642478027 0.998627005047973 0 0 0.185301968137852 0 0 0.409616397225003 0 0 0.185301968137852 0 0 4.84974073048892 0.607039227313767 NA NA False True 0 0 0 0 0 1 0 0 0 1.59041726002428 0 0 0.00331481736263177 0.997684291779235 0.996342642478027 0.998627005047973 142 Not assoc w R Previous WHO guidance 4) Not assoc w R - Interim DOWN from NotAwR to NotAwRI yes Prev. WHO 3 +Amikacin whiB7 c.180T>G whiB7_c.180T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin whiB7 c.18C>A whiB7_c.18C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 8 2460 21970 0 0 0.00149842073847528 0.999635999635999 0.999282900840091 0.999842837798826 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.2353912865109 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin whiB7 c.18C>T whiB7_c.18C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 21.6259333410942 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin whiB7 c.-195C>T whiB7_c.-195C>T 1 upstream_gene_variant 3568874 1 18 0 18 0 20 2460 21958 0 0 0.00149842073847528 0.999089999089999 0.998594925555303 0.999444061992291 0 0 0.168433470983085 0 0 0.185301968137852 0 0 0.168433470983085 0 0 2.03178717162472 0.247999477580608 81 1832 False False 0 0 1.80940756951692 0 0 0.00149842073847528 0.999089999089999 0.998594925555303 0.999444061992291 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 1111 7769 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 16.9323809419784 1 267 981 False False 0 0 0 0 0 0 0 0 0 10.6044836876068 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 4 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-200G>T whiB7_c.-200G>T 1 upstream_gene_variant 3568879 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-203_-202insC whiB7_c.-203_-202insC 1 upstream_gene_variant 3568881 1 2 1 1 1 1 2459 21977 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.9999544999545 0.999746516336938 0.999998848039248 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 8.93737291581943 0.113810496005924 697.318539256027 0.191196488852352 72.5 1832 False False 8.93737291581943 0.113810496005924 697.318539256027 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-203_-202insCC whiB7_c.-203_-202insCC 1 upstream_gene_variant 3568881 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB7 c.-205_-204insA whiB7_c.-205_-204insA 1 upstream_gene_variant 3568883 1 4 0 4 0 4 2460 21974 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 13.5427650126618 1 662.5 1832 False False 0 0 13.5427650126618 0 0 0.00149842073847528 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 4 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-212A>C whiB7_c.-212A>C 1 upstream_gene_variant 3568891 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-214_-213insA whiB7_c.-214_-213insA 1 upstream_gene_variant 3568892 0 0 0 0 3 1 2457 21977 0.00121951219512195 0.00025156337591866 0.00355975660270706 0.9999544999545 0.999746516336938 0.999998848039248 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 1156 1832 False False 26.8339438339438 2.15301335174262 1395.79975994304 0 0 0.00150024893893223 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 1108 7773 0.0027002700270027 0.000557207149395569 0.00787087587058421 1 0.999525536566873 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 456 981 False False 0 0 0 0 0 0 0 Inf 2.89424461850611 Inf 0 0 0.00332377756768462 1 0.999525536566873 1 1 3) Uncertain significance New Uncertain no 0 +Amikacin whiB7 c.-214A>C whiB7_c.-214A>C 1 upstream_gene_variant 3568893 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 5 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-215_-214delCA whiB7_c.-215_-214delCA 1 upstream_gene_variant 3568892 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB7 c.-215delC whiB7_c.-215delC 1 upstream_gene_variant 3568893 1 7 0 7 2 17 2458 21961 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.999226499226499 0.99876183824676 0.999549344777619 0.105263157894736 0.0130121643717774 0.331376664456765 0 0 0.409616397225003 0 0 0.195064322969093 0 0 6.20281996097457 1 1139.5 1832 False False 1.0511175991959 0.117710938762851 4.4327233739406 0 0 0.00149963904330158 0.999226499226499 0.99876183824676 0.999549344777619 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 2 0 2 1 4 1110 7769 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.999485398173163 0.998682943858046 0.999859771090489 0.2 0.00505076337946806 0.716417936118089 0 0 0.841886116991581 0 0 0.602364635616474 0 0 37.2865584546612 1 267 981 False False 0 0 0 0 0 0 0 1.74977477477477 0.0354986069371523 17.6959481769957 0 0 0.00331779872508707 0.999485398173163 0.998682943858046 0.999859771090489 9 3) Uncertain significance New Uncertain no 0 +Amikacin whiB7 c.-217C>G whiB7_c.-217C>G 1 upstream_gene_variant 3568896 1 3 0 3 3 4 2457 21974 0.00121951219512195 0.00025156337591866 0.00355975660270706 0.999817999817999 0.999534073414941 0.999950408920832 0.428571428571428 0.0989882784425078 0.815948432359917 0 0 0.707598226178713 0 0 0.602364635616474 0 0 21.6513415477254 1 165 1832 False False 6.7075702075702 0.981840926473112 39.6690812973678 0 0 0.00150024893893223 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 4 1110 7769 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.999485398173163 0.998682943858046 0.999859771090489 0.2 0.00505076337946806 0.716417936118089 0 0 0.707598226178713 0 0 0.602364635616474 0 0 16.9475358051211 1 267 981 False False 0 0 0 0 0 0 0 1.74977477477477 0.0354986069371523 17.6959481769957 0 0 0.00331779872508707 0.999485398173163 0.998682943858046 0.999859771090489 2 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-221A>C whiB7_c.-221A>C 1 upstream_gene_variant 3568900 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1141 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-221delA whiB7_c.-221delA 1 upstream_gene_variant 3568899 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1160 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-227G>C whiB7_c.-227G>C 1 upstream_gene_variant 3568906 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-235T>C whiB7_c.-235T>C 1 upstream_gene_variant 3568914 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1155 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-23C>A whiB7_c.-23C>A 1 upstream_gene_variant 3568702 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1167 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-240C>G whiB7_c.-240C>G 1 upstream_gene_variant 3568919 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 37.2625869115887 1 267 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 NA 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-242G>C whiB7_c.-242G>C 1 upstream_gene_variant 3568921 1 53 1 52 2 65 2458 21913 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.997042497042497 0.996231950972383 0.997716742567293 0.0298507462686567 0.00363573072690439 0.103707507647554 0.0188679245283018 0.000477580412422113 0.100701526769146 0.0151515151515151 0.000383529584995338 0.0815523210948241 0.171441760030043 0.00426144969267478 0.999272277995008 0.0399798359295981 20 1832 False False 0.274306816048069 0.0325070285233045 1.03270438269093 0.000406669377795852 1.02959242167344e-05 0.0022637116293895 0.997042497042497 0.996231950972383 0.997716742567293 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 21 0 21 0 25 1111 7748 0 0 0.00331481736263177 0.996783738582272 0.995255800421733 0.997917556794295 0 0 0.137185171530712 0 0 0.161097615219079 0 0 0.137185171530712 0 0 1.34163161046739 0.0993003759732767 18 981 False False 0 0 0 0 0 0 0 0 0 1.1108481392852 0 0 0.00331481736263177 0.996783738582272 0.995255800421733 0.997917556794295 97 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-24A>G whiB7_c.-24A>G 1 upstream_gene_variant 3568703 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-250G>A whiB7_c.-250G>A 1 upstream_gene_variant 3568929 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1148 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 450 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-257G>A whiB7_c.-257G>A 1 upstream_gene_variant 3568936 1 1 1 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.22908065008664 Inf 0.100662902037809 42.5 1832 False False Inf 0.22908065008664 Inf 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin whiB7 c.-258T>G whiB7_c.-258T>G 1 upstream_gene_variant 3568937 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-265A>C whiB7_c.-265A>C 1 upstream_gene_variant 3568944 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB7 c.-26A>C whiB7_c.-26A>C 1 upstream_gene_variant 3568705 0 0 0 0 1 2 2459 21976 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999908999909 0.999671315452743 0.999988979276808 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1175 1832 False False 4.46848312322082 0.0757100934104112 86.0774363890598 0 0 0.00149902964335061 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1110 7773 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 1 0.999525536566873 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 472 981 False False 0 0 0 0 0 0 0 Inf 0.179394825906045 Inf 0 0 0.00331779872508707 1 0.999525536566873 1 2 3) Uncertain significance New Uncertain no 0 +Amikacin whiB7 c.-278G>C whiB7_c.-278G>C 1 upstream_gene_variant 3568957 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-279G>T whiB7_c.-279G>T 1 upstream_gene_variant 3568958 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-282C>T whiB7_c.-282C>T 1 upstream_gene_variant 3568961 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance New Uncertain no 0 +Amikacin whiB7 c.-289G>A whiB7_c.-289G>A 1 upstream_gene_variant 3568968 1 5 0 5 0 5 2460 21973 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 9.75275991328737 1 662.5 1832 False False 0 0 9.75275991328737 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-295A>C whiB7_c.-295A>C 1 upstream_gene_variant 3568974 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-305_-304insG whiB7_c.-305_-304insG 1 upstream_gene_variant 3568983 0 0 0 0 2 0 2458 21978 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 1 0.99983216990204 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1143 1832 False False Inf 1.67834993427241 Inf 0 0 0.00149963904330158 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB7 c.-307_-306insGG whiB7_c.-307_-306insGG 1 upstream_gene_variant 3568985 1 8 0 8 0 8 2460 21970 0 0 0.00149842073847528 0.999635999635999 0.999282900840091 0.999842837798826 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 5.2353912865109 1 165 1832 False False 0 0 5.2353912865109 0 0 0.00149842073847528 0.999635999635999 0.999282900840091 0.999842837798826 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 1111 7769 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 10.6044836876068 1 267 981 False False 0 0 0 0 0 0 0 0 0 10.6044836876068 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 6 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-317_-316insG whiB7_c.-317_-316insG 1 upstream_gene_variant 3568995 1 4 1 3 1 3 2459 21975 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.9998634998635 0.999601141012814 0.999971849505602 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 2.97885319235461 0.0567200675769732 37.1234870649317 0.345848866503538 87.5 1832 False False 2.97885319235461 0.0567200675769732 37.1234870649317 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 2 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-317G>A whiB7_c.-317G>A 1 upstream_gene_variant 3568996 0 0 0 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1146 1832 False False Inf 0.22908065008664 Inf 0 0 0.00149902964335061 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1110 7773 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 1 0.999525536566873 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 448 981 False False 0 0 0 0 0 0 0 Inf 0.179394825906045 Inf 0 0 0.00331779872508707 1 0.999525536566873 1 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB7 c.-318_-317delGG whiB7_c.-318_-317delGG 1 upstream_gene_variant 3568995 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-322G>C whiB7_c.-322G>C 1 upstream_gene_variant 3569001 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-328G>A whiB7_c.-328G>A 1 upstream_gene_variant 3569007 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-32G>A whiB7_c.-32G>A 1 upstream_gene_variant 3568711 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-338G>T whiB7_c.-338G>T 1 upstream_gene_variant 3569017 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB7 c.-33C>G whiB7_c.-33C>G 1 upstream_gene_variant 3568712 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 10 3) Uncertain significance New Uncertain no 0 +Amikacin whiB7 c.-340delC whiB7_c.-340delC 1 upstream_gene_variant 3569018 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1170 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-341C>A whiB7_c.-341C>A 1 upstream_gene_variant 3569020 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-350A>G whiB7_c.-350A>G 1 upstream_gene_variant 3569029 1 13 0 13 0 27 2460 21951 0 0 0.00149842073847528 0.998771498771498 0.998213094756864 0.999190258727253 0 0 0.127702867615432 0 0 0.24705263800047 0 0 0.127702867615432 0 0 2.92983391985263 0.633664220888103 139 1832 False False 0 0 1.30739522757667 0 0 0.00149842073847528 0.998771498771498 0.998213094756864 0.999190258727253 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 0 13 1111 7760 0 0 0.00331481736263177 0.998327544062781 0.997141747487123 0.999109196577396 0 0 0.24705263800047 0 0 0.336267116879942 0 0 0.24705263800047 0 0 3.54404269120463 0.613315883955368 57 981 False False 0 0 0 0 0 0 0 0 0 2.29557234301212 0 0 0.00331481736263177 0.998327544062781 0.997141747487123 0.999109196577396 156 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-351C>T whiB7_c.-351C>T 1 upstream_gene_variant 3569030 1 1 1 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.22908065008664 Inf 0.100662902037809 42.5 1832 False False Inf 0.22908065008664 Inf 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Amikacin whiB7 c.-353C>A whiB7_c.-353C>A 1 upstream_gene_variant 3569032 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 3 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-355G>A whiB7_c.-355G>A 1 upstream_gene_variant 3569034 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-358C>T whiB7_c.-358C>T 1 upstream_gene_variant 3569037 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1161 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-360T>C whiB7_c.-360T>C 1 upstream_gene_variant 3569039 1 2 0 2 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 47.551166952306 1 165 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-360T>G whiB7_c.-360T>G 1 upstream_gene_variant 3569039 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1163 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 461 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-375T>C whiB7_c.-375T>C 1 upstream_gene_variant 3569054 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-37G>A whiB7_c.-37G>A 1 upstream_gene_variant 3568716 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB7 c.-386T>C whiB7_c.-386T>C 1 upstream_gene_variant 3569065 1 27 0 27 1 36 2459 21942 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.998361998361998 0.997733029382952 0.998852508231344 0.027027027027027 0.000684031024694665 0.141603095611158 0 0 0.127702867615432 0 0 0.0973937559144919 0 0 1.30739107329366 0.105172764075483 60 1832 False False 0.247864985766571 0.00610872799966375 1.47342046198585 0 0 0.00149902964335061 0.998361998361998 0.997733029382952 0.998852508231344 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 0 12 1111 7761 0 0 0.00331481736263177 0.99845619451949 0.997304837007313 0.999202046759043 0 0 0.264648469397051 0 0 0.30849710781876 0 0 0.264648469397051 0 0 3.12111992958414 0.624087292574 60 981 False False 0 0 0 0 0 0 0 0 0 2.51816344117143 0 0 0.00331481736263177 0.99845619451949 0.997304837007313 0.999202046759043 53 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-390G>T whiB7_c.-390G>T 1 upstream_gene_variant 3569069 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB7 c.-392C>T whiB7_c.-392C>T 1 upstream_gene_variant 3569071 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB7 c.-396A>G whiB7_c.-396A>G 1 upstream_gene_variant 3569075 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-401T>G whiB7_c.-401T>G 1 upstream_gene_variant 3569080 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin whiB7 c.48G>A whiB7_c.48G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin whiB7 c.-49A>G whiB7_c.-49A>G 1 upstream_gene_variant 3568728 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-50G>A whiB7_c.-50G>A 1 upstream_gene_variant 3568729 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-53C>T whiB7_c.-53C>T 1 upstream_gene_variant 3568732 1 17 0 17 0 20 2460 21958 0 0 0.00149842073847528 0.999089999089999 0.998594925555303 0.999444061992291 0 0 0.168433470983085 0 0 0.195064322969093 0 0 0.168433470983085 0 0 2.16459573009046 0.405876305067016 99 1832 False False 0 0 1.80940756951692 0 0 0.00149842073847528 0.999089999089999 0.998594925555303 0.999444061992291 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 445 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 18 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-55delG whiB7_c.-55delG 1 upstream_gene_variant 3568733 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-55G>A whiB7_c.-55G>A 1 upstream_gene_variant 3568734 1 5 0 5 0 5 2460 21973 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 9.75275991328737 1 662.5 1832 False False 0 0 9.75275991328737 0 0 0.00149842073847528 0.999772499772499 0.99946917089695 0.999926127301238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 1111 7769 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 10.6044836876068 1 267 981 False False 0 0 0 0 0 0 0 0 0 10.6044836876068 0 0 0.00331481736263177 0.999485398173163 0.998682943858046 0.999859771090489 8 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-55G>T whiB7_c.-55G>T 1 upstream_gene_variant 3568734 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 5 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-56G>A whiB7_c.-56G>A 1 upstream_gene_variant 3568735 1 4 0 4 1 4 2459 21974 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.999817999817999 0.999534073414941 0.999950408920832 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 13.5482881491524 1 662.5 1832 False False 2.23403822692151 0.045345258756558 22.5860023464291 0 0 0.00149902964335061 0.999817999817999 0.999534073414941 0.999950408920832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 1110 7772 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.99987134954329 0.999283416286792 0.999996742857744 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 271.949173528644 1 75.5 981 False False 0 0 0 0 0 0 0 7.0018018018018 0.0891187877143753 547.10724479397 0 0 0.00331779872508707 0.99987134954329 0.999283416286792 0.999996742857744 2 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-56G>T whiB7_c.-56G>T 1 upstream_gene_variant 3568735 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin whiB7 c.57G>A whiB7_c.57G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 271.705433977597 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin whiB7 c.-57T>C whiB7_c.-57T>C 1 upstream_gene_variant 3568736 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB7 c.-57T>G whiB7_c.-57T>G 1 upstream_gene_variant 3568736 1 51 4 47 10 57 2450 21921 0.0040650406504065 0.00195101362065822 0.00746300821583156 0.997406497406497 0.996641105138744 0.998035132678408 0.149253731343283 0.0739646848424509 0.257402452607778 0.0784313725490196 0.021783562056269 0.188806006942538 0.0655737704918032 0.0181541959759684 0.15946895464071 0.761476335214937 0.199079936277988 2.0852373491496 0.815400379487597 143 1832 False False 1.56970998925886 0.71368391763371 3.10650447749479 0.00162999185004074 0.000444290880723741 0.00416812166582756 0.997406497406497 0.996641105138744 0.998035132678408 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 25 1 24 5 29 1106 7744 0.0045004500450045 0.00146284970071471 0.0104710615528963 0.996269136755435 0.994646219128581 0.99750000175145 0.147058823529411 0.0495284552561774 0.310565730395125 0.04 0.00101219969931084 0.203516913922414 0.0333333333333333 0.000843570926630479 0.172169455633412 0.291742013261 0.007091365309337 1.79290317365833 0.356695598527595 37 981 False False 0 0 0 0 0 0 0 1.20720833073517 0.364072740775331 3.16306992477026 0.000903342366757 2.28703870543381e-05 0.00502272107003252 0.996269136755435 0.994646219128581 0.99750000175145 10 3) Uncertain significance No change no 1 +Amikacin whiB7 c.60C>T whiB7_c.60C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 47.5533224929027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin whiB7 c.-65A>G whiB7_c.-65A>G 1 upstream_gene_variant 3568744 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1165 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 462 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-66C>G whiB7_c.-66C>G 1 upstream_gene_variant 3568745 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1162 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 460 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin whiB7 c.66C>T whiB7_c.66C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 346.55041664634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin whiB7 c.-68C>G whiB7_c.-68C>G 1 upstream_gene_variant 3568747 1 1 1 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.22908065008664 Inf 0.100662902037809 42.5 1832 False False Inf 0.22908065008664 Inf 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB7 c.-71_-70insC whiB7_c.-71_-70insC 1 upstream_gene_variant 3568749 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB7 c.-71C>G whiB7_c.-71C>G 1 upstream_gene_variant 3568750 1 3 0 3 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 21.6259333410942 1 662.5 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-78A>G whiB7_c.-78A>G 1 upstream_gene_variant 3568757 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-7A>G whiB7_c.-7A>G 1 upstream_gene_variant 3568686 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1179 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-80A>C whiB7_c.-80A>C 1 upstream_gene_variant 3568759 1 53 3 50 5 51 2455 21927 0.00203252032520325 0.000660272864287742 0.00473679855039338 0.997679497679497 0.996950082779819 0.998271760486254 0.0892857142857142 0.0296298418895422 0.196193440934782 0.0566037735849056 0.0118287188591336 0.156629462172374 0.0555555555555555 0.0116067743799413 0.153885033791633 0.535894093686354 0.106828232363912 1.66083783115929 0.365557500828569 90 1832 False False 0.875643943931951 0.272456060843302 2.18299297751881 0.00122050447518307 0.000251768122957734 0.00356264967008346 0.997679497679497 0.996950082779819 0.998271760486254 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 45 1 44 3 44 1108 7729 0.0027002700270027 0.000557207149395569 0.00787087587058421 0.994339379904798 0.992408252393362 0.995884061006228 0.0638297872340425 0.0133617694972549 0.17539243001292 0.0222222222222222 0.000562459715402258 0.117704331418294 0.0222222222222222 0.000562459715402258 0.117704331418294 0.158537085658024 0.003925823763512 0.9327519408454 0.0381384969549142 11 981 False False 0 0 0 0 0 0 0 0.475611256974072 0.0943149344013575 1.48778234294611 0.000901713255184851 2.28291424628202e-05 0.00501368162626477 0.994339379904798 0.992408252393362 0.995884061006228 14 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-89A>G whiB7_c.-89A>G 1 upstream_gene_variant 3568768 1 9 0 9 0 9 2460 21969 0 0 0.00149842073847528 0.999590499590499 0.999222783640785 0.999812733785825 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.336267116879942 0 0 4.52743474605681 0.612226157450036 119.5 1832 False False 0 0 4.52743474605681 0 0 0.00149842073847528 0.999590499590499 0.999222783640785 0.999812733785825 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 2 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-8A>T whiB7_c.-8A>T 1 upstream_gene_variant 3568687 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1149 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 451 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 6 3) Uncertain significance No change no 1 +Amikacin whiB7 c.-97G>A whiB7_c.-97G>A 1 upstream_gene_variant 3568776 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB7 c.99G>A whiB7_c.99G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 2459 21977 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 0.9999544999545 0.999746516336938 0.999998848039248 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 8.93737291581943 0.113810496005924 697.318539256027 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 1110 7772 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.99987134954329 0.999283416286792 0.999996742857744 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 7.0018018018018 0.0891187877143753 547.10724479397 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Amikacin whiB7 LoF whiB7_LoF 1 LoF (see "Genomic_coordinates" sheet) 1 91 2 89 19 154 2441 21824 0.00772357723577235 0.00465631696332551 0.0120351534940211 0.992992992992993 0.991799704616779 0.994052933040536 0.109826589595375 0.0674315480653685 0.166186999171883 0.0219780219780219 0.00267281142662426 0.0771453927546017 0.0128205128205128 0.00155641217381038 0.0455430156728557 0.20091231720284 0.0239321789655211 0.748260976526324 0.00778978588750253 16 1832 False False 1.10306080646105 0.645281224032604 1.78592413901593 0.000818665575112566 9.91595804072412e-05 0.00295414093554268 0.992992992992993 0.991799704616779 0.994052933040536 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 40 0 40 5 62 1106 7711 0.0045004500450045 0.00146284970071471 0.0104710615528963 0.992023671684034 0.989786218734747 0.993879284020372 0.0746268656716417 0.0246747065995901 0.165626166204845 0 0 0.0880973028788023 0 0 0.0577626344292909 0 0 0.674833961833367 0.00741449942710008 7 981 False False 0 0 0 0 0 0 0 0.562255731202239 0.176020352615049 1.38841287517307 0 0 0.00332977799752235 0.992023671684034 0.989786218734747 0.993879284020372 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB7 p.Ala39Thr whiB7_p.Ala39Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1178 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 476 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin whiB7 p.Ala55Glu whiB7_p.Ala55Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB7 p.Ala90Ser whiB7_p.Ala90Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB7 p.Ala92Thr whiB7_p.Ala92Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1166 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1111 7771 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 463 981 False False 0 0 0 0 0 0 0 0 0 37.2625869115887 0 0 0.00331481736263177 0.999742699086581 0.999070852951501 0.999968838146642 1 3) Uncertain significance New Uncertain no 0 +Amikacin whiB7 p.Ala92Val whiB7_p.Ala92Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.22908065008664 Inf 0.100662902037809 42.5 1832 False False Inf 0.22908065008664 Inf 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1110 7773 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 1 0.999525536566873 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.179394825906045 Inf 0.125056280954525 25.5 981 False False 0 0 0 0 0 0 0 Inf 0.179394825906045 Inf 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 1 0.999525536566873 1 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB7 p.Arg12fs whiB7_p.Arg12fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Amikacin whiB7 p.Arg12Lys whiB7_p.Arg12Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin whiB7 p.Arg50Leu whiB7_p.Arg50Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 2460 21975 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1142 1832 False False 0 0 21.6259333410942 0 0 0.00149842073847528 0.9998634998635 0.999601141012814 0.999971849505602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Amikacin whiB7 p.Arg50Pro whiB7_p.Arg50Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1147 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 449 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance No change no 1 +Amikacin whiB7 p.Arg59Trp whiB7_p.Arg59Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin whiB7 p.Arg81Cys whiB7_p.Arg81Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin whiB7 p.Arg81fs whiB7_p.Arg81fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 11 44 2449 21934 0.00447154471544715 0.00223422829333408 0.00798671208990131 0.997997997997998 0.997313327283976 0.998544977024108 0.2 0.104295916925768 0.329728506287614 0 0 0.975 0 0 0.0804199397635758 0 0 347.421167982925 1 662.5 1832 False False 2.23907717435688 1.04141558631878 4.41287306844651 0 0 0.00150514602125516 0.997997997997998 0.997313327283976 0.998544977024108 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 12 1109 7761 0.0018001800180018 0.000218084550259369 0.00648759665094944 0.99845619451949 0.997304837007313 0.999202046759043 0.142857142857142 0.0177945154831915 0.428129160909698 NA NA NA 0 0 0.264648469397051 NA NA NA NA 474 981 False False 0 0 0 0 0 0 0 1.1663660955816 0.126598112174593 5.24932422822807 0 0 0.00332078545526824 0.99845619451949 0.997304837007313 0.999202046759043 14 3) Uncertain significance New Uncertain no 0 +Amikacin whiB7 p.Arg81His whiB7_p.Arg81His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1151 1832 False False Inf 0.22908065008664 Inf 0 0 0.00149902964335061 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1110 7773 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 1 0.999525536566873 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 452 981 False False 0 0 0 0 0 0 0 Inf 0.179394825906045 Inf 0 0 0.00331779872508707 1 0.999525536566873 1 NA 3) Uncertain significance No change no 1 +Amikacin whiB7 p.Arg87Cys whiB7_p.Arg87Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB7 p.Asp24His whiB7_p.Asp24His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 346.534733964433 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 467 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 16 3) Uncertain significance No change no 1 +Amikacin whiB7 p.Asp26Gly whiB7_p.Asp26Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1152 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 453 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin whiB7 p.Asp31Asn whiB7_p.Asp31Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Amikacin whiB7 p.Gln13Lys whiB7_p.Gln13Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB7 p.Gln58Arg whiB7_p.Gln58Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 7 2460 21971 0 0 0.00149842073847528 0.999681499681499 0.999343878425726 0.999871937071415 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 7.59008565309221 1 662.5 1832 False False 0 0 6.20059597931892 0 0 0.00149842073847528 0.999681499681499 0.999343878425726 0.999871937071415 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance No change no 1 +Amikacin whiB7 p.Gln73Arg whiB7_p.Gln73Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB7 p.Glu69Gly whiB7_p.Glu69Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Amikacin whiB7 p.Glu69Lys whiB7_p.Glu69Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB7 p.Gly23Asp whiB7_p.Gly23Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Amikacin whiB7 p.Gly64fs whiB7_p.Gly64fs 1 frameshift (see "Genomic_coordinates" sheet) 1 85 1 84 2 98 2458 21880 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 0.995540995540995 0.994568553180307 0.996378526420358 0.02 0.00243133682394254 0.0703839324710701 0.0117647058823529 0.000297812209658448 0.0638128785535283 0.0101010101010101 0.000255702736665961 0.0549968231994302 0.105970785384943 0.00265448186591716 0.607370705998609 0.00301970423979576 12 1832 False True 0.181664203517045 0.0216836721332214 0.67476432546473 0.000406669377795852 1.02959242167344e-05 0.0022637116293895 0.995540995540995 0.994568553180307 0.996378526420358 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 38 0 38 0 48 1111 7725 0 0 0.00331481736263177 0.993824778077962 0.991820795804122 0.99544347175401 0 0 0.0739727853472802 0 0 0.0925127614158782 0 0 0.0739727853472802 0 0 0.710170255617173 0.0115924212182639 8 981 False True 1 1 1 0 0 0 0 0 0 0.556503722708433 0 0 0.00331481736263177 0.993824778077962 0.991820795804122 0.99544347175401 817 5) Not assoc w R New NotAwR yes 5 +Amikacin whiB7 p.Gly67Val whiB7_p.Gly67Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 12 3) Uncertain significance New Uncertain no 0 +Amikacin whiB7 p.Gly74Asp whiB7_p.Gly74Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1180 1832 False False Inf 0.22908065008664 Inf 0 0 0.00149902964335061 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1110 7773 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 1 0.999525536566873 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 477 981 False False 0 0 0 0 0 0 0 Inf 0.179394825906045 Inf 0 0 0.00331779872508707 1 0.999525536566873 1 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB7 p.Gly84_Arg87del whiB7_p.Gly84_Arg87del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 6 1 5 5 15 2455 21963 0.00203252032520325 0.000660272864287742 0.00473679855039338 0.999317499317499 0.998874568358369 0.999617960830416 0.25 0.0865714691014345 0.491045871707957 0.166666666666666 0.00421074451448947 0.641234578997674 0.0625 0.00158111172276588 0.302320738434531 1.78924643584521 0.0378143416099128 15.998070718785 0.470565122764911 103 1832 False False 2.98207739307535 0.847090889974686 8.64020476493089 0.000407166123778501 1.03085006065741e-05 0.00226647417628752 0.999317499317499 0.998874568358369 0.999617960830416 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 3 1109 7770 0.0018001800180018 0.000218084550259369 0.00648759665094944 0.999614048629872 0.998872504682436 0.999920400475616 0.4 0.0527449505263169 0.853367200365326 NA NA NA 0 0 0.707598226178713 NA NA NA NA 466 981 False False 0 0 0 0 0 0 0 4.67087466185752 0.389614743310331 40.8502933343974 0 0 0.00332078545526824 0.999614048629872 0.998872504682436 0.999920400475616 43 3) Uncertain significance New Uncertain no 0 +Amikacin whiB7 p.His21Gln whiB7_p.His21Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB7 p.His79fs whiB7_p.His79fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1173 1832 False False Inf 0.22908065008664 Inf 0 0 0.00149902964335061 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1110 7773 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 1 0.999525536566873 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 470 981 False False 0 0 0 0 0 0 0 Inf 0.179394825906045 Inf 0 0 0.00331779872508707 1 0.999525536566873 1 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB7 p.His79Gln whiB7_p.His79Gln 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 12 49 2448 21929 0.0048780487804878 0.00252302251619196 0.00850545023157134 0.997770497770497 0.997053538314743 0.998350160756174 0.196721311475409 0.105994219870432 0.31842119542927 NA NA NA 0 0 0.0725192636642774 NA NA NA NA 1171 1832 False False 2.1937775110044 1.06050644460795 4.19193739396938 0 0 0.00150576040534729 0.997770497770497 0.997053538314743 0.998350160756174 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 12 1109 7761 0.0018001800180018 0.000218084550259369 0.00648759665094944 0.99845619451949 0.997304837007313 0.999202046759043 0.142857142857142 0.0177945154831915 0.428129160909698 NA NA NA 0 0 0.264648469397051 NA NA NA NA 468 981 False False 0 0 0 0 0 0 0 1.1663660955816 0.126598112174593 5.24932422822807 0 0 0.00332078545526824 0.99845619451949 0.997304837007313 0.999202046759043 14 3) Uncertain significance No change no 1 +Amikacin whiB7 p.Ile76Val whiB7_p.Ile76Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB7 p.Leu18Phe whiB7_p.Leu18Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Amikacin whiB7 p.Leu27Pro whiB7_p.Leu27Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1176 1832 False False Inf 0.22908065008664 Inf 0 0 0.00149902964335061 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1110 7773 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 1 0.999525536566873 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 473 981 False False 0 0 0 0 0 0 0 Inf 0.179394825906045 Inf 0 0 0.00331779872508707 1 0.999525536566873 1 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB7 p.Leu42Pro whiB7_p.Leu42Pro 1 missense_variant (see "Genomic_coordinates" sheet) 2 34 0 34 6 40 2454 21938 0.0024390243902439 0.000895588528695574 0.00530111511191433 0.998179998179998 0.997522490030905 0.998699455493482 0.130434782608695 0.04940734657371 0.262565016187626 0 0 0.102817924259012 0 0 0.0880973028788023 0 0 1.02535696119822 0.0444886449938345 21 1832 False False 1.34095354523227 0.464151799564698 3.18703721669338 0 0 0.00150208160595732 0.998179998179998 0.997522490030905 0.998699455493482 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 5 1110 7768 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 0.999356747716454 0.998499507558406 0.999791105797204 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA 0 0 0.521823750104981 NA NA NA NA 446 981 False False 0 0 0 0 0 0 0 1.39963963963963 0.0295658812501739 12.524223051576 0 0 0.00331779872508707 0.999356747716454 0.998499507558406 0.999791105797204 15 3) Uncertain significance No change no 1 +Amikacin whiB7 p.Lys40Asn whiB7_p.Lys40Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 47.5533224929027 1 662.5 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB7 p.Lys80Gln whiB7_p.Lys80Gln 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 12 49 2448 21929 0.0048780487804878 0.00252302251619196 0.00850545023157134 0.997770497770497 0.997053538314743 0.998350160756174 0.196721311475409 0.105994219870432 0.31842119542927 NA NA NA 0 0 0.0725192636642774 NA NA NA NA 1158 1832 False False 2.1937775110044 1.06050644460795 4.19193739396938 0 0 0.00150576040534729 0.997770497770497 0.997053538314743 0.998350160756174 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 12 1109 7761 0.0018001800180018 0.000218084550259369 0.00648759665094944 0.99845619451949 0.997304837007313 0.999202046759043 0.142857142857142 0.0177945154831915 0.428129160909698 NA NA NA 0 0 0.264648469397051 NA NA NA NA 458 981 False False 0 0 0 0 0 0 0 1.1663660955816 0.126598112174593 5.24932422822807 0 0 0.00332078545526824 0.99845619451949 0.997304837007313 0.999202046759043 14 3) Uncertain significance No change no 1 +Amikacin whiB7 p.Lys88Thr whiB7_p.Lys88Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 3 3) Uncertain significance No change no 1 +Amikacin whiB7 p.Met1? whiB7_p.Met1? 1 start_lost (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1168 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 464 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance New Uncertain no 0 +Amikacin whiB7 p.Phe29Ile whiB7_p.Phe29Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1164 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB7 p.Pro11Ser whiB7_p.Pro11Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 7 2460 21971 0 0 0.00149842073847528 0.999681499681499 0.999343878425726 0.999871937071415 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 7.59008565309221 1 662.5 1832 False False 0 0 6.20059597931892 0 0 0.00149842073847528 0.999681499681499 0.999343878425726 0.999871937071415 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 10 3) Uncertain significance No change no 1 +Amikacin whiB7 p.Pro25Leu whiB7_p.Pro25Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1182 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 479 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance New Uncertain no 0 +Amikacin whiB7 p.Pro33Ser whiB7_p.Pro33Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1157 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB7 p.Pro62Thr whiB7_p.Pro62Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1181 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 478 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance No change no 1 +Amikacin whiB7 p.Ser2Ala whiB7_p.Ser2Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Amikacin whiB7 p.Ser45Arg whiB7_p.Ser45Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 2459 21978 0.00040650406504065 1.02917389032242e-05 0.00226279227634722 1 0.99983216990204 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1172 1832 False False Inf 0.22908065008664 Inf 0 0 0.00149902964335061 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1110 7773 0.0009000900090009 2.27880463649893e-05 0.00500467466075002 1 0.999525536566873 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 469 981 False False 0 0 0 0 0 0 0 Inf 0.179394825906045 Inf 0 0 0.00331779872508707 1 0.999525536566873 1 1 3) Uncertain significance New Uncertain no 0 +Amikacin whiB7 p.Ser45Gly whiB7_p.Ser45Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1174 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 471 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB7 p.Ser78Asn whiB7_p.Ser78Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 0 0 0.975 0 0 0.975 0 0 271.705433977597 1 267 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 1 3) Uncertain significance No change no 1 +Amikacin whiB7 p.Thr10_Gln13del whiB7_p.Thr10_Gln13del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin whiB7 p.Thr10Ser whiB7_p.Thr10Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB7 p.Thr32Asn whiB7_p.Thr32Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1145 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin whiB7 p.Trp63* whiB7_p.Trp63* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB7 p.Val22Ile whiB7_p.Val22Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Amikacin whiB7 p.Val3Ala whiB7_p.Val3Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 2460 21976 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1150 1832 False False 0 0 47.5533224929027 0 0 0.00149842073847528 0.999908999909 0.999671315452743 0.999988979276808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Amikacin whiB7 p.Val65fs whiB7_p.Val65fs 1 frameshift (see "Genomic_coordinates" sheet) 2 7 0 7 5 9 2455 21969 0.00203252032520325 0.000660272864287742 0.00473679855039338 0.999590499590499 0.999222783640785 0.999812733785825 0.357142857142857 0.127598429859159 0.648619889384008 0 0 0.409616397225003 0 0 0.336267116879942 0 0 6.21266748992654 1 662.5 1832 False False 4.97148676171079 1.30761643971552 16.5308477619691 0 0 0.00150147021965361 0.999590499590499 0.999222783640785 0.999812733785825 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 1 1109 7772 0.0018001800180018 0.000218084550259369 0.00648759665094944 0.99987134954329 0.999283416286792 0.999996742857744 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 465 981 False False 0 0 0 0 0 0 0 14.0162308385933 0.72870395111684 822.225420011683 0 0 0.00332078545526824 0.99987134954329 0.999283416286792 0.999996742857744 5 3) Uncertain significance No change no 1 +Amikacin whiB7 p.Val65Phe whiB7_p.Val65Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1177 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1111 7772 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 475 981 False False 0 0 0 0 0 0 0 0 0 271.705433977597 0 0 0.00331481736263177 0.99987134954329 0.999283416286792 0.999996742857744 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB7 p.Val91Gly whiB7_p.Val91Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 2458 21978 0.0008130081300813 9.8474225684694e-05 0.00293374781960632 1 0.99983216990204 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1144 1832 False False Inf 1.67834993427241 Inf 0 0 0.00149963904330158 1 0.99983216990204 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 1109 7773 0.0018001800180018 0.000218084550259369 0.00648759665094944 1 0.999525536566873 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 447 981 False False 0 0 0 0 0 0 0 Inf 1.31458832505494 Inf 0 0 0.00332078545526824 1 0.999525536566873 1 NA 3) Uncertain significance New Uncertain no 0 +Amikacin whiB7 p.Val91Ile whiB7_p.Val91Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2460 21977 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 0 0 0.975 0 0 0.975 0 0 0.975 0 0 346.55041664634 1 662.5 1832 False False 0 0 346.55041664634 0 0 0.00149842073847528 0.9999544999545 0.999746516336938 0.999998848039248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline atpE c.207G>T atpE_c.207G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 10 1035 12941 0 0 0.00355779074923997 0.999227858852598 0.998580464895556 0.999629668183042 0 0 0.30849710781876 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.58682568371909 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 64 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline atpE c.240C>T atpE_c.240C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline atpE c.-41T>C atpE_c.-41T>C 1 upstream_gene_variant 1461004 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Bedaquiline atpE c.-43G>T atpE_c.-43G>T 1 upstream_gene_variant 1461002 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline atpE c.54C>A atpE_c.54C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 2 1033 12949 0.00193236714975845 0.000234104356582827 0.00696277826632085 0.999845571770519 0.999442264649511 0.999981297477798 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 12.5353339787028 0.907371535939867 172.888916289171 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline atpE c.9C>T atpE_c.9C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline atpE p.Ala45Val atpE_p.Ala45Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline atpE p.Ala62Thr atpE_p.Ala62Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline atpE p.Ala63Pro atpE_p.Ala63Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 5 0 7 0 1028 12951 0.00676328502415459 0.00272338773585253 0.0138850260502618 1 0.999715206999795 1 1 0.590383602774996 1 1 0.478176249895018 1 1 0.478176249895018 1 Inf 11.5207080873539 Inf 2.179941331791e-06 21 1032 True False Inf 18.1198273495572 Inf 0.00484027105517909 0.00157343430590966 0.01125915847555 1 0.999715206999795 1 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance 1 3 3 0 4 0 897 1249 0.00443951165371809 0.00121090206228936 0.0113275932937957 1 0.997050890854678 1 1 0.397635364383525 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.573976292709167 Inf 0.0733121237990831 31 299 False False 0 0 0 0 0 0 0 Inf 0.916560415731825 Inf 0.00333333333333333 0.000687941699489156 0.00971024624724392 1 0.997050890854678 1 NA Marker of R Evidence from ALL dataset only 2) Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV New AwRI yes ALL only C 5 +Bedaquiline atpE p.Ala63Thr atpE_p.Ala63Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 664 1032 False False Inf 0.320847254634342 Inf 0 0 0.00356122541865182 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 227 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0 0 0.00409036651757122 1 0.997050890854678 1 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline atpE p.Ala63Val atpE_p.Ala63Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 5 0 1030 12951 0.00483091787439613 0.00157039035246783 0.0112374718131471 1 0.999715206999795 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 665 1032 False False Inf 11.4983851517043 Inf 0 0 0.00357503066948213 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline atpE p.Asp28Ala atpE_p.Asp28Ala 1 missense_variant (see "Genomic_coordinates" sheet) NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA Marker of R Selection evidence 2) Assoc w R - Interim New AwRI yes Selection 5 +Bedaquiline atpE p.Asp28Gly atpE_p.Asp28Gly 1 missense_variant (see "Genomic_coordinates" sheet) NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA Marker of R Selection evidence 2) Assoc w R - Interim New AwRI yes Selection 5 +Bedaquiline atpE p.Asp28Val atpE_p.Asp28Val 1 missense_variant (see "Genomic_coordinates" sheet) NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA Marker of R Selection evidence 2) Assoc w R - Interim New AwRI yes Selection 5 +Bedaquiline atpE p.Glu61Asp atpE_p.Glu61Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 2 2 2 3 1033 12948 0.00193236714975845 0.000234104356582827 0.00696277826632085 0.999768357655779 0.999323193486146 0.999952227231941 0.4 0.0527449505263169 0.853367200365326 0.5 0.067585986488543 0.932414013511457 0.4 0.0527449505263169 0.853367200365326 12.5343659244917 0.907301476213234 172.875611024639 0.029688970539487 89 1032 False False 8.35624394966118 0.69696757697323 73.0040625445438 0.00193236714975845 0.000234104356582827 0.00696277826632085 0.999768357655779 0.999323193486146 0.999952227231941 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Marker of R Selection evidence 2) Assoc w R - Interim UP from Uncertain to AwRI yes Selection 4 +Bedaquiline atpE p.Ile66Met atpE_p.Ile66Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 6 0 7 0 1028 12951 0.00676328502415459 0.00272338773585253 0.0138850260502618 1 0.999715206999795 1 1 0.590383602774996 1 1 0.540741873560099 1 1 0.540741873560099 1 Inf 14.8016381475801 Inf 1.61176927927916e-07 14 1032 True False Inf 18.1198273495572 Inf 0.0058027079303675 0.0021323797808414 0.0125869787817078 1 0.999715206999795 1 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance 1 6 6 0 7 0 894 1249 0.00776914539400666 0.00312913909316045 0.0159415364957336 1 0.997050890854678 1 1 0.590383602774996 1 1 0.540741873560099 1 1 0.540741873560099 1 Inf 1.63950478893088 Inf 0.00534339763294628 17.5 299 False False 0 0 0 0 0 0 0 Inf 2.0065805970492 Inf 0.00666666666666666 0.00245036285732616 0.0144536801734451 1 0.997050890854678 1 1 Marker of R Evidence from ALL dataset only 2) Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV New AwRI yes ALL only C 5 +Bedaquiline atpE p.Leu59Phe atpE_p.Leu59Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 0 0 0.975 0 0 0.975 0 0 54.0184755945099 1 186 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline atpE p.Phe76Leu atpE_p.Phe76Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 0 0 0.975 0 0 0.975 0 0 54.0184755945099 1 186 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline atpE p.Ser37Ala atpE_p.Ser37Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 0 0 0.975 0 0 0.975 0 0 54.0184755945099 1 186 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 1 3) Uncertain significance No change no 1 +Bedaquiline atpE p.Thr51Ile atpE_p.Thr51Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline atpE p.Val39Ile atpE_p.Val39Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 663 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Bedaquiline lpqB c.1011C>A lpqB_c.1011C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.1023A>G lpqB_c.1023A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.1047C>T lpqB_c.1047C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.1059C>T lpqB_c.1059C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.1098C>T lpqB_c.1098C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.1104T>G lpqB_c.1104T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.1107G>A lpqB_c.1107G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.1119G>T lpqB_c.1119G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.1125G>A lpqB_c.1125G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.1140C>T lpqB_c.1140C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 54.0184755945099 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.1146C>T lpqB_c.1146C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.1188C>T lpqB_c.1188C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.1236C>G lpqB_c.1236C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.123A>G lpqB_c.123A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.1275C>T lpqB_c.1275C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.1302G>T lpqB_c.1302G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 28 1035 12923 0 0 0.00355779074923997 0.997838004787275 0.996876819299296 0.998562903942649 0 0 0.123436118500263 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.76139393740407 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 901 1247 0 0 0.0040858359972341 0.99839871897518 0.994227708034801 0.999806018576913 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 7.38115169544997 NA NA NA NA NA NA 60 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.1326G>A lpqB_c.1326G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.1389G>T lpqB_c.1389G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.1404C>T lpqB_c.1404C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.1443T>C lpqB_c.1443T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.1452G>A lpqB_c.1452G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 9 1035 12942 0 0 0.00355779074923997 0.999305072967338 0.998681223764717 0.999682187439592 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 6.34492522562988 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 901 1246 0 0 0.0040858359972341 0.99759807846277 0.992996755835892 0.999504391864096 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.35381326044578 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.1473G>A lpqB_c.1473G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.150G>A lpqB_c.150G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.1518A>G lpqB_c.1518A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 54.0184755945099 NA NA NA NA NA NA 33 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.1527C>T lpqB_c.1527C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.1530C>T lpqB_c.1530C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.1539G>A lpqB_c.1539G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.1539G>C lpqB_c.1539G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 54.0184755945099 NA NA NA NA NA NA 72 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.1560C>T lpqB_c.1560C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.1620C>A lpqB_c.1620C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 10 1035 12941 0 0 0.00355779074923997 0.999227858852598 0.998580464895556 0.999629668183042 0 0 0.30849710781876 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.58682568371909 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 54.0184755945099 NA NA NA NA NA NA 36 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.1635G>A lpqB_c.1635G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 9 5 1026 12946 0.00869565217391304 0.003983694112966 0.0164426238532791 0.999613929426299 0.999099271995683 0.999874632432309 0.642857142857142 0.351380110615991 0.87240157014084 NA NA NA NA NA NA NA NA NA NA NA NA False False 22.7122807017543 6.81532510048426 86.4089955921791 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 7 3 894 1246 0.00776914539400666 0.00312913909316045 0.0159415364957336 0.99759807846277 0.992996755835892 0.999504391864096 0.7 0.347547149940002 0.933260488822265 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.25205070842654 0.739544050870348 19.5303514631629 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.1689A>G lpqB_c.1689A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 81 1035 12870 0 0 0.00355779074923997 0.993745656706046 0.992232333240381 0.995030136931722 0 0 0.0445202624563217 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.580535107877557 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 28 901 1221 0 0 0.0040858359972341 0.977582065652522 0.967761881166787 0.98505297857761 0 0 0.123436118500263 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.191622081209468 NA NA NA NA NA NA 608 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.16T>C lpqB_c.16T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.1710G>A lpqB_c.1710G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 1035 12947 0 0 0.00355779074923997 0.999691143541039 0.99920939533685 0.999915840803364 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 18.9615575493326 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.1725G>A lpqB_c.1725G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.1737G>C lpqB_c.1737G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 5 1034 12946 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999613929426299 0.999099271995683 0.999874632432309 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.50406189555125 0.0528921651376963 22.4053576430098 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 54.0184755945099 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.1740A>G lpqB_c.1740A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.1746C>G lpqB_c.1746C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.174C>T lpqB_c.174C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.189C>G lpqB_c.189C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.189C>T lpqB_c.189C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 5 1034 12946 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999613929426299 0.999099271995683 0.999874632432309 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.50406189555125 0.0528921651376963 22.4053576430098 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf NA NA NA NA NA NA 13 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.18G>A lpqB_c.18G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 9 1035 12942 0 0 0.00355779074923997 0.999305072967338 0.998681223764717 0.999682187439592 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 6.34492522562988 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.201G>A lpqB_c.201G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 22 1035 12929 0 0 0.00355779074923997 0.998301289475716 0.997429254797082 0.998935130529021 0 0 0.154372512815574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.28446143189156 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 901 1247 0 0 0.0040858359972341 0.99839871897518 0.994227708034801 0.999806018576913 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 7.38115169544997 NA NA NA NA NA NA 222 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.264G>A lpqB_c.264G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.279G>A lpqB_c.279G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.318G>A lpqB_c.318G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 26 1035 12925 0 0 0.00355779074923997 0.997992433016755 0.99705982312981 0.998688184453792 0 0 0.132274604497754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.9070804448488 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 901 1247 0 0 0.0040858359972341 0.99839871897518 0.994227708034801 0.999806018576913 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 7.38115169544997 NA NA NA NA NA NA 274 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.504C>T lpqB_c.504C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.513C>T lpqB_c.513C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.519C>T lpqB_c.519C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.522C>A lpqB_c.522C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.549G>A lpqB_c.549G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.549G>T lpqB_c.549G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.561G>T lpqB_c.561G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 38 1035 12913 0 0 0.00355779074923997 0.997065863639873 0.99597487067054 0.997922819293648 0 0 0.0925127614158782 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.27427839926074 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 901 1247 0 0 0.0040858359972341 0.99839871897518 0.994227708034801 0.999806018576913 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 7.38115169544997 NA NA NA NA NA NA 422 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.588G>A lpqB_c.588G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 7 13 1028 12938 0.00676328502415459 0.00272338773585253 0.0138850260502618 0.998996216508377 0.998284111345339 0.999465422742454 0.35 0.153909204784541 0.592188534532828 NA NA NA NA NA NA NA NA NA NA NA NA False False 6.7768632146064 2.28339176739705 18.311518648669 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 7 2 894 1247 0.00776914539400666 0.00312913909316045 0.0159415364957336 0.99839871897518 0.994227708034801 0.999806018576913 0.777777777777777 0.399906426283687 0.971855026522101 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.88199105145413 0.926015868038757 48.2343176064924 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.642G>T lpqB_c.642G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.654C>T lpqB_c.654C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 1035 12947 0 0 0.00355779074923997 0.999691143541039 0.99920939533685 0.999915840803364 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 18.9615575493326 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.657T>C lpqB_c.657T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.684G>A lpqB_c.684G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.729C>G lpqB_c.729C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.729C>T lpqB_c.729C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.75G>C lpqB_c.75G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.765C>A lpqB_c.765C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.810C>T lpqB_c.810C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.825C>T lpqB_c.825C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.831G>A lpqB_c.831G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 30.2740898875531 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.879T>C lpqB_c.879T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 54.0184755945099 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.894C>T lpqB_c.894C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.900C>G lpqB_c.900C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.909G>A lpqB_c.909G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.909G>C lpqB_c.909G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.921G>C lpqB_c.921G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 30.2740898875531 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 901 1247 0 0 0.0040858359972341 0.99839871897518 0.994227708034801 0.999806018576913 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 7.38115169544997 NA NA NA NA NA NA 15 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.924G>T lpqB_c.924G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.951G>A lpqB_c.951G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.957C>T lpqB_c.957C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 901 1247 0 0 0.0040858359972341 0.99839871897518 0.994227708034801 0.999806018576913 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 7.38115169544997 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.990A>C lpqB_c.990A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.999C>A lpqB_c.999C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB c.999C>T lpqB_c.999C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 30.2740898875531 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 54.0184755945099 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline lpqB p.Ala187Thr lpqB_p.Ala187Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 913 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Ala204Val lpqB_p.Ala204Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 893 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Ala24Thr lpqB_p.Ala24Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 895 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Ala294Val lpqB_p.Ala294Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 884 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Ala303Val lpqB_p.Ala303Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 910 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Ala314Ser lpqB_p.Ala314Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 5 1035 12946 0 0 0.00355779074923997 0.999613929426299 0.999099271995683 0.999874632432309 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 903 1032 False False 0 0 13.6669955985752 0 0 0.00355779074923997 0.999613929426299 0.999099271995683 0.999874632432309 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 901 1246 0 0 0.0040858359972341 0.99759807846277 0.992996755835892 0.999504391864096 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 279 299 False False 0 0 0 0 0 0 0 0 0 3.35381326044578 0 0 0.0040858359972341 0.99759807846277 0.992996755835892 0.999504391864096 17 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Ala327Val lpqB_p.Ala327Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 875 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Ala368Thr lpqB_p.Ala368Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 896 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Ala373Glu lpqB_p.Ala373Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 897 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Ala373Ser lpqB_p.Ala373Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 883 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Ala384Ser lpqB_p.Ala384Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 3 1034 12948 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999768357655779 0.999323193486146 0.999952227231941 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 915 1032 False False 4.17408123791102 0.0794342529077097 52.0327209025694 0 0 0.00356122541865182 0.999768357655779 0.999323193486146 0.999952227231941 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 283 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0 0 0.00409036651757122 1 0.997050890854678 1 24 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Ala416Val lpqB_p.Ala416Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 924 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Ala456Val lpqB_p.Ala456Val 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 5 1032 12946 0.00289855072463768 0.000598150191171612 0.00844722324607505 0.999613929426299 0.999099271995683 0.999874632432309 0.375 0.0852334141372535 0.755136783633448 NA NA NA 0 0 0.521823750104981 NA NA NA NA 887 1032 False False 7.52674418604651 1.16688624407011 38.7143163810439 0 0 0.00356811469079427 0.999613929426299 0.999099271995683 0.999874632432309 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 277 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0 0 0.00409036651757122 1 0.997050890854678 1 23 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Ala548Ser lpqB_p.Ala548Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 864 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Ala548Thr lpqB_p.Ala548Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 916 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Ala58Ser lpqB_p.Ala58Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 885 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Ala77Val lpqB_p.Ala77Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 900 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Ala84Gly lpqB_p.Ala84Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 15 1035 12936 0 0 0.00355779074923997 0.998841788278897 0.998090424264354 0.999351617364021 0 0 0.218019360910534 NA NA NA 0 0 0.218019360910534 NA NA NA NA 872 1032 False False 0 0 3.49054489880335 0 0 0.00355779074923997 0.998841788278897 0.998090424264354 0.999351617364021 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 275 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 57 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Arg240Cys lpqB_p.Arg240Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 901 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Arg240Leu lpqB_p.Arg240Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 911 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Arg332Pro lpqB_p.Arg332Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 870 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Arg342Gln lpqB_p.Arg342Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 879 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 276 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 2 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Asn322Lys lpqB_p.Asn322Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 856 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Asp142Gly lpqB_p.Asp142Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 10 0 10 75 788 960 12163 0.072463768115942 0.0574206760212043 0.0899897718426074 0.939155277584742 0.934900061244663 0.943211799930102 0.0869061413673232 0.0689691046584493 0.107720403692652 0 0 0.30849710781876 0 0 0.00467037880825769 0 0 5.66186533059807 1 216 1032 False False 1.20588118654822 0.930105718278547 1.54486657104989 0 0 0.00383520949071212 0.939155277584742 0.934900061244663 0.943211799930102 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 71 49 830 1200 0.0788013318534961 0.0620546802248006 0.0983605924943028 0.960768614891913 0.948463419172867 0.970838039107218 0.591666666666666 0.498203378374688 0.680495127934268 NA NA NA 0 0 0.0725192636642774 NA NA NA NA 278 299 False False 0 0 0 0 0 0 0 2.09491025325793 1.41842080848762 3.11301817145211 0 0 0.00443457120011716 0.960768614891913 0.948463419172867 0.970838039107218 4197 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Asp301Gly lpqB_p.Asp301Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 871 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Asp311Glu lpqB_p.Asp311Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 865 1032 False False 0 0 30.2740898875531 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 274 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 7 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Asp525His lpqB_p.Asp525His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 859 1032 False False 0 0 30.2740898875531 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Gln193Pro lpqB_p.Gln193Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 866 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Glu250Ala lpqB_p.Glu250Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 906 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 12 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Gly278Glu lpqB_p.Gly278Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 857 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Gly338Trp lpqB_p.Gly338Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 919 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Gly381Ser lpqB_p.Gly381Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 898 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Gly45Val lpqB_p.Gly45Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 861 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Gly549Ser lpqB_p.Gly549Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Gly576Thr lpqB_p.Gly576Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 888 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.His258Arg lpqB_p.His258Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 868 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.His391Tyr lpqB_p.His391Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 907 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Ile282Val lpqB_p.Ile282Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 876 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Leu364Pro lpqB_p.Leu364Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 882 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Leu380Phe lpqB_p.Leu380Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 917 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Leu400Val lpqB_p.Leu400Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 920 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Leu51Val lpqB_p.Leu51Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 889 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Leu52Ser lpqB_p.Leu52Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 890 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Leu581Val lpqB_p.Leu581Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 6 1035 12945 0 0 0.00355779074923997 0.999536715311559 0.998991899081557 0.999829964314549 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 894 1032 False False 0 0 10.6366244843314 0 0 0.00355779074923997 0.999536715311559 0.998991899081557 0.999829964314549 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Lys165Thr lpqB_p.Lys165Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 891 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Met108Thr lpqB_p.Met108Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 921 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 284 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Met343Thr lpqB_p.Met343Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 880 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Phe55Leu lpqB_p.Phe55Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 873 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 12 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Pro132Ser lpqB_p.Pro132Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 860 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Pro279Ser lpqB_p.Pro279Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 908 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Pro34Gln lpqB_p.Pro34Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 1035 12947 0 0 0.00355779074923997 0.999691143541039 0.99920939533685 0.999915840803364 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 862 1032 False False 0 0 18.9615575493326 0 0 0.00355779074923997 0.999691143541039 0.99920939533685 0.999915840803364 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Pro34Ser lpqB_p.Pro34Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 922 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Pro420Leu lpqB_p.Pro420Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 9 1035 12942 0 0 0.00355779074923997 0.999305072967338 0.998681223764717 0.999682187439592 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 912 1032 False False 0 0 6.34492522562988 0 0 0.00355779074923997 0.999305072967338 0.998681223764717 0.999682187439592 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 901 1246 0 0 0.0040858359972341 0.99759807846277 0.992996755835892 0.999504391864096 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 282 299 False False 0 0 0 0 0 0 0 0 0 3.35381326044578 0 0 0.0040858359972341 0.99759807846277 0.992996755835892 0.999504391864096 18 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Pro527Ala lpqB_p.Pro527Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 8 1035 12943 0 0 0.00355779074923997 0.999382287082078 0.998783224071471 0.999733278885799 0 0 0.369416647552819 0 0 0.975 0 0 0.369416647552819 0 0 484.063436561977 1 426 1032 False False 0 0 7.3371961646121 0 0 0.00355779074923997 0.999382287082078 0.998783224071471 0.999733278885799 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Pro534Ala lpqB_p.Pro534Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 863 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Pro550Ser lpqB_p.Pro550Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 925 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Pro564Leu lpqB_p.Pro564Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 904 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Pro570Ser lpqB_p.Pro570Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 886 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Pro575Gln lpqB_p.Pro575Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Ser18Gly lpqB_p.Ser18Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 902 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Ser21Arg lpqB_p.Ser21Arg 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 1034 12950 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999922785885259 0.999569866411227 0.99999804510978 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 858 1032 False False 12.5241779497098 0.159396979672639 974.620016429296 0 0 0.00356122541865182 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 273 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0 0 0.00409036651757122 1 0.997050890854678 1 3 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Ser394Leu lpqB_p.Ser394Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 22 1035 12929 0 0 0.00355779074923997 0.998301289475716 0.997429254797082 0.998935130529021 0 0 0.154372512815574 NA NA NA 0 0 0.154372512815574 NA NA NA NA 909 1032 False False 0 0 2.28446143189156 0 0 0.00355779074923997 0.998301289475716 0.997429254797082 0.998935130529021 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 901 1247 0 0 0.0040858359972341 0.99839871897518 0.994227708034801 0.999806018576913 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 281 299 False False 0 0 0 0 0 0 0 0 0 7.38115169544997 0 0 0.0040858359972341 0.99839871897518 0.994227708034801 0.999806018576913 217 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Ser491Leu lpqB_p.Ser491Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 923 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Ser557Leu lpqB_p.Ser557Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 892 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Ser562Arg lpqB_p.Ser562Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 874 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Thr347Met lpqB_p.Thr347Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 914 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Thr433Ser lpqB_p.Thr433Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 869 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Thr479Asn lpqB_p.Thr479Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 899 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Thr479Ser lpqB_p.Thr479Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 918 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Thr536Met lpqB_p.Thr536Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 877 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Val228Met lpqB_p.Val228Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 867 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Val31Ile lpqB_p.Val31Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 878 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Val492Ala lpqB_p.Val492Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 905 1032 False False 0 0 30.2740898875531 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 280 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 4 3) Uncertain significance New Uncertain no 0 +Bedaquiline lpqB p.Val560Ile lpqB_p.Val560Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 881 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 c.1032C>G mmpL5_c.1032C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.1065G>A mmpL5_c.1065G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.1065G>T mmpL5_c.1065G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 29 177 1006 12774 0.0280193236714975 0.0188435375926976 0.0399938883657363 0.986333101690989 0.984181905727615 0.98826144314025 0.140776699029126 0.0963504490349023 0.195882725107041 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.08043265828756 1.34664209421756 3.11189775732357 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 27 4 874 1245 0.0299667036625971 0.0198391758457295 0.0433020022155578 0.99679743795036 0.991820638117455 0.999126741506926 0.870967741935483 0.701664170992202 0.963698338020791 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 9.61527459954233 3.33038827159896 37.91467437369 NA NA NA NA NA NA 226 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.1068G>A mmpL5_c.1068G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.1110C>T mmpL5_c.1110C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.1128G>A mmpL5_c.1128G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.1128G>T mmpL5_c.1128G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.1131G>C mmpL5_c.1131G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.1143G>A mmpL5_c.1143G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.1158C>T mmpL5_c.1158C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 16 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.1161C>G mmpL5_c.1161C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 15 1035 12936 0 0 0.00355779074923997 0.998841788278897 0.998090424264354 0.999351617364021 0 0 0.218019360910534 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.49054489880335 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 63 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.1194G>C mmpL5_c.1194G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.1230C>T mmpL5_c.1230C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.1326G>C mmpL5_c.1326G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.1335C>T mmpL5_c.1335C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.135C>T mmpL5_c.135C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 1034 12949 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999845571770519 0.999442264649511 0.999981297477798 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 6.26160541586073 0.106032338278929 120.386237357489 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.1395C>A mmpL5_c.1395C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.1425G>C mmpL5_c.1425G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.1431G>C mmpL5_c.1431G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 30.2740898875531 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.1437C>T mmpL5_c.1437C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 54.0184755945099 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.1473G>T mmpL5_c.1473G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.1569G>A mmpL5_c.1569G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.1572G>A mmpL5_c.1572G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.1584C>T mmpL5_c.1584C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.1593C>T mmpL5_c.1593C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.1674G>A mmpL5_c.1674G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.1758C>T mmpL5_c.1758C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 1035 12946 0 0 0.00355779074923997 0.999613929426299 0.999099271995683 0.999874632432309 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 13.6669955985752 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.1785G>A mmpL5_c.1785G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.1791C>T mmpL5_c.1791C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.183G>A mmpL5_c.183G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 123 1034 12828 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.990502663886958 0.988678743693018 0.992100741226195 0.00806451612903225 0.000204155028366464 0.0441130038852007 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.100863329716469 0.00253465933192178 0.573900534005026 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 5 900 1244 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 0.99599679743795 0.990682777281159 0.998698932354597 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.276444444444444 0.00584283736605212 2.47770522871791 NA NA NA NA NA NA 386 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.1875G>A mmpL5_c.1875G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.1896C>T mmpL5_c.1896C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.189G>A mmpL5_c.189G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.18A>G mmpL5_c.18A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 1035 12947 0 0 0.00355779074923997 0.999691143541039 0.99920939533685 0.999915840803364 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 18.9615575493326 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 26 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.1926C>T mmpL5_c.1926C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.1941C>T mmpL5_c.1941C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 12 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.195C>T mmpL5_c.195C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.1A>G mmpL5_c.1A>G 1 initiator_codon_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 14 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.2070T>C mmpL5_c.2070T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 17 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.2079C>G mmpL5_c.2079C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 1035 12946 0 0 0.00355779074923997 0.999613929426299 0.999099271995683 0.999874632432309 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 13.6669955985752 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 901 1247 0 0 0.0040858359972341 0.99839871897518 0.994227708034801 0.999806018576913 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 7.38115169544997 NA NA NA NA NA NA 12 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.2115G>A mmpL5_c.2115G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 54.0184755945099 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.2145G>C mmpL5_c.2145G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.2214C>T mmpL5_c.2214C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.2241G>A mmpL5_c.2241G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.2250G>T mmpL5_c.2250G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.2265G>T mmpL5_c.2265G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 30.2740898875531 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.2340A>G mmpL5_c.2340A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.2400G>A mmpL5_c.2400G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.2412C>T mmpL5_c.2412C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.243G>A mmpL5_c.243G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.2475C>T mmpL5_c.2475C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 7 1035 12944 0 0 0.00355779074923997 0.999459501196818 0.998886684999561 0.999782664716124 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.6896253144418 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 34 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.2493G>A mmpL5_c.2493G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.24G>A mmpL5_c.24G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 22 1035 12929 0 0 0.00355779074923997 0.998301289475716 0.997429254797082 0.998935130529021 0 0 0.154372512815574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.28446143189156 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.2502G>A mmpL5_c.2502G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 9 1035 12942 0 0 0.00355779074923997 0.999305072967338 0.998681223764717 0.999682187439592 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 6.34492522562988 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 54.0184755945099 NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.2527C>T mmpL5_c.2527C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.2529G>A mmpL5_c.2529G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.258C>T mmpL5_c.258C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.2634G>T mmpL5_c.2634G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.2658G>T mmpL5_c.2658G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.2664T>C mmpL5_c.2664T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 1035 12947 0 0 0.00355779074923997 0.999691143541039 0.99920939533685 0.999915840803364 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 18.9615575493326 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.2721C>T mmpL5_c.2721C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.2730C>A mmpL5_c.2730C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.2739C>G mmpL5_c.2739C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.273G>A mmpL5_c.273G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.2742G>A mmpL5_c.2742G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.2751C>T mmpL5_c.2751C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.2757G>A mmpL5_c.2757G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 30.2740898875531 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.2760C>A mmpL5_c.2760C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.2766G>A mmpL5_c.2766G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 8 1035 12943 0 0 0.00355779074923997 0.999382287082078 0.998783224071471 0.999733278885799 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.3371961646121 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 54.0184755945099 NA NA NA NA NA NA 34 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.2781G>T mmpL5_c.2781G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 24 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.2838A>G mmpL5_c.2838A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.2871G>A mmpL5_c.2871G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.2886C>G mmpL5_c.2886C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.320847254634342 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.2889G>A mmpL5_c.2889G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 7 7 1028 12944 0.00676328502415459 0.00272338773585253 0.0138850260502618 0.999459501196818 0.998886684999561 0.999782664716124 0.5 0.230360541448062 0.769639458551937 NA NA NA NA NA NA NA NA NA NA NA NA False False 12.5914396887159 3.75884769663249 42.1676609957291 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 7 0 894 1249 0.00776914539400666 0.00312913909316045 0.0159415364957336 1 0.997050890854678 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 2.0065805970492 Inf NA NA NA NA NA NA 67 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.303C>T mmpL5_c.303C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.30G>A mmpL5_c.30G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 30.2740898875531 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.360C>T mmpL5_c.360C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 54.0184755945099 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.375C>G mmpL5_c.375C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.3G>A mmpL5_c.3G>A 1 initiator_codon_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.414C>A mmpL5_c.414C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.462G>A mmpL5_c.462G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.465C>T mmpL5_c.465C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.480A>C mmpL5_c.480A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.495C>A mmpL5_c.495C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.504G>C mmpL5_c.504G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.507C>T mmpL5_c.507C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 22 1035 12929 0 0 0.00355779074923997 0.998301289475716 0.997429254797082 0.998935130529021 0 0 0.154372512815574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.28446143189156 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 5 901 1244 0 0 0.0040858359972341 0.99599679743795 0.990682777281159 0.998698932354597 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.51093957896194 NA NA NA NA NA NA 51 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.576G>A mmpL5_c.576G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.636C>T mmpL5_c.636C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.661C>T mmpL5_c.661C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 4 15 1031 12936 0.0038647342995169 0.00105398325986622 0.009865452176262 0.998841788278897 0.998090424264354 0.999351617364021 0.210526315789473 0.0605245377092897 0.455653081891505 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.3458777885548 0.80672945206531 10.5242703729938 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 4 4 897 1245 0.00443951165371809 0.00121090206228936 0.0113275932937957 0.99679743795036 0.991820638117455 0.999126741506926 0.5 0.157012770487058 0.842987229512941 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.38795986622073 0.257733587270365 7.46982231189223 NA NA NA NA NA NA 97 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.678C>A mmpL5_c.678C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 54.0184755945099 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.702G>A mmpL5_c.702G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 54.0184755945099 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.729C>G mmpL5_c.729C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.738C>G mmpL5_c.738C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.750C>T mmpL5_c.750C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.762G>A mmpL5_c.762G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.768T>C mmpL5_c.768T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.777G>A mmpL5_c.777G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 7 1035 12944 0 0 0.00355779074923997 0.999459501196818 0.998886684999561 0.999782664716124 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.6896253144418 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 901 1246 0 0 0.0040858359972341 0.99759807846277 0.992996755835892 0.999504391864096 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.35381326044578 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.798C>T mmpL5_c.798C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.841C>T mmpL5_c.841C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.855C>T mmpL5_c.855C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 1035 12946 0 0 0.00355779074923997 0.999613929426299 0.999099271995683 0.999874632432309 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 13.6669955985752 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 901 1247 0 0 0.0040858359972341 0.99839871897518 0.994227708034801 0.999806018576913 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 7.38115169544997 NA NA NA NA NA NA 12 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.885G>A mmpL5_c.885G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.891G>A mmpL5_c.891G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.894G>A mmpL5_c.894G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 3 1034 12948 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999768357655779 0.999323193486146 0.999952227231941 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 4.17408123791102 0.0794342529077097 52.0327209025694 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.894G>C mmpL5_c.894G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.909C>T mmpL5_c.909C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 5 1034 12946 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999613929426299 0.999099271995683 0.999874632432309 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.50406189555125 0.0528921651376963 22.4053576430098 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf NA NA NA NA NA NA 101 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.931C>T mmpL5_c.931C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.972G>A mmpL5_c.972G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.984A>G mmpL5_c.984A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 54.0184755945099 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 c.9G>A mmpL5_c.9G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpL5 LoF mmpL5_LoF 1 LoF (see "Genomic_coordinates" sheet) 1 209 0 209 0 247 1035 12704 0 0 0.00355779074923997 0.980928113659176 0.97842283921175 0.983213824659908 0 0 0.0148237646055962 0 0 0.0174952895791865 0 0 0.0148237646055962 0 0 0.219011864044369 1.57437136775775e-07 13 1032 True False 0 0 0.185049920228839 0 0 0.00355779074923997 0.980928113659176 0.97842283921175 0.983213824659908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 4 901 1245 0 0 0.0040858359972341 0.99679743795036 0.991820638117455 0.999126741506926 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 7.36932693384606 0.512746554674618 152 299 False False 0 0 0 0 0 0 0 0 0 2.09854624946918 0 0 0.0040858359972341 0.99679743795036 0.991820638117455 0.999126741506926 NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations New Uncertain yes D 0 +Bedaquiline mmpL5 p.Ala136_Ala139del mmpL5_p.Ala136_Ala139del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Ala147Thr mmpL5_p.Ala147Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 11 0 11 0 13 1035 12938 0 0 0.00355779074923997 0.998996216508377 0.998284111345339 0.999465422742454 0 0 0.24705263800047 0 0 0.284914152918154 0 0 0.24705263800047 0 0 4.98850171657414 1 426 1032 False False 0 0 4.10826345921427 0 0 0.00355779074923997 0.998996216508377 0.998284111345339 0.999465422742454 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 68 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Ala199Thr mmpL5_p.Ala199Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Ala209Thr mmpL5_p.Ala209Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 624 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Ala20Thr mmpL5_p.Ala20Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 621 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Ala230Thr mmpL5_p.Ala230Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 0 8 1035 12943 0 0 0.00355779074923997 0.999382287082078 0.998783224071471 0.999733278885799 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 7.3371961646121 1 426 1032 False False 0 0 7.3371961646121 0 0 0.00355779074923997 0.999382287082078 0.998783224071471 0.999733278885799 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 7 901 1242 0 0 0.0040858359972341 0.99439551641313 0.988486910078977 0.99774382672033 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.959419595137795 0.0462856343367132 30 299 False False 0 0 0 0 0 0 0 0 0 0.959419595137795 0 0 0.0040858359972341 0.99439551641313 0.988486910078977 0.99774382672033 6 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Ala230Val mmpL5_p.Ala230Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 30.2740898875531 1 426 1032 False False 0 0 30.2740898875531 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 14 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Ala273Gly mmpL5_p.Ala273Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Ala273Thr mmpL5_p.Ala273Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Ala288Pro mmpL5_p.Ala288Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Ala350del mmpL5_p.Ala350del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 1035 12947 0 0 0.00355779074923997 0.999691143541039 0.99920939533685 0.999915840803364 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 30.2718366149006 1 426 1032 False False 0 0 18.9615575493326 0 0 0.00355779074923997 0.999691143541039 0.99920939533685 0.999915840803364 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 14 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Ala359Thr mmpL5_p.Ala359Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 1 3 1 3 1034 12948 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999768357655779 0.999323193486146 0.999952227231941 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 4.17408123791102 0.0794342529077097 52.0327209025694 0.264768296337548 172 1032 False False 4.17408123791102 0.0794342529077097 52.0327209025694 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999768357655779 0.999323193486146 0.999952227231941 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Ala385Thr mmpL5_p.Ala385Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Ala397Ser mmpL5_p.Ala397Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Ala401Val mmpL5_p.Ala401Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Ala434Thr mmpL5_p.Ala434Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Ala44Gly mmpL5_p.Ala44Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Ala572Val mmpL5_p.Ala572Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 1035 12947 0 0 0.00355779074923997 0.999691143541039 0.99920939533685 0.999915840803364 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 18.9615575493326 1 426 1032 False False 0 0 18.9615575493326 0 0 0.00355779074923997 0.999691143541039 0.99920939533685 0.999915840803364 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Ala667Ser mmpL5_p.Ala667Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 619 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Ala679Asp mmpL5_p.Ala679Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Ala69Val mmpL5_p.Ala69Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Ala800Ser mmpL5_p.Ala800Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Ala801Val mmpL5_p.Ala801Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Ala896Thr mmpL5_p.Ala896Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Ala8fs mmpL5_p.Ala8fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations New Uncertain no D 0 +Bedaquiline mmpL5 p.Ala956fs mmpL5_p.Ala956fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations No change no D 1 +Bedaquiline mmpL5 p.Arg115fs mmpL5_p.Arg115fs 1 frameshift (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 30.2740898875531 1 426 1032 False False 0 0 30.2740898875531 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations No change no D 1 +Bedaquiline mmpL5 p.Arg202fs mmpL5_p.Arg202fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 19 1035 12932 0 0 0.00355779074923997 0.998532931819936 0.99770993520076 0.999116505271597 0 0 0.176466911806965 NA NA NA 0 0 0.176466911806965 NA NA NA NA 617 1032 False False 0 0 2.68200124116364 0 0 0.00355779074923997 0.998532931819936 0.99770993520076 0.999116505271597 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 215 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 64 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations No change no D 1 +Bedaquiline mmpL5 p.Arg244Leu mmpL5_p.Arg244Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Arg254Gln mmpL5_p.Arg254Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 644 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 221 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Arg284fs mmpL5_p.Arg284fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations No change no D 1 +Bedaquiline mmpL5 p.Arg289His mmpL5_p.Arg289His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Arg328Gly mmpL5_p.Arg328Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 3 0 3 0 1032 12951 0.00289855072463768 0.000598150191171612 0.00844722324607505 1 0.999715206999795 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 5.17684059997845 Inf 0.000404179051296263 37.5 1032 True False Inf 5.17684059997845 Inf 0.00289855072463768 0.000598150191171612 0.00844722324607505 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 3 0 3 0 898 1249 0.00332963374028856 0.000687177581788976 0.00969950356574711 1 0.997050890854678 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.573338395820229 Inf 0.0734544040745661 38 299 False False 0 0 0 0 0 0 0 Inf 0.573338395820229 Inf 0.00332963374028856 0.000687177581788976 0.00969950356574711 1 0.997050890854678 1 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Arg380His mmpL5_p.Arg380His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Arg717Gln mmpL5_p.Arg717Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Arg944Gln mmpL5_p.Arg944Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Asn458Asp mmpL5_p.Asn458Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 640 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Asn466Ser mmpL5_p.Asn466Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Asn685Asp mmpL5_p.Asn685Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 618 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Asn772Ser mmpL5_p.Asn772Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 30.2740898875531 1 426 1032 False False 0 0 30.2740898875531 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Asp110Gly mmpL5_p.Asp110Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 0 0 0.975 0 0 0.975 0 0 54.0184755945099 1 186 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Asp128Ala mmpL5_p.Asp128Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Asp128Asn mmpL5_p.Asp128Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 5 1035 12946 0 0 0.00355779074923997 0.999613929426299 0.999099271995683 0.999874632432309 0 0 0.521823750104981 0 0 0.841886116991581 0 0 0.521823750104981 0 0 66.5878132359898 1 426 1032 False False 0 0 13.6669955985752 0 0 0.00355779074923997 0.999613929426299 0.999099271995683 0.999874632432309 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 42 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Asp128His mmpL5_p.Asp128His 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 622 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Asp132fs mmpL5_p.Asp132fs 1 frameshift (see "Genomic_coordinates" sheet) 1 9 0 9 0 9 1035 12942 0 0 0.00355779074923997 0.999305072967338 0.998681223764717 0.999682187439592 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.336267116879942 0 0 6.34492522562988 1 426 1032 False False 0 0 6.34492522562988 0 0 0.00355779074923997 0.999305072967338 0.998681223764717 0.999682187439592 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 64 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations No change no D 1 +Bedaquiline mmpL5 p.Asp143Gly mmpL5_p.Asp143Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Asp424Asn mmpL5_p.Asp424Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 1035 12946 0 0 0.00355779074923997 0.999613929426299 0.999099271995683 0.999874632432309 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 18.9601075494708 1 426 1032 False False 0 0 13.6669955985752 0 0 0.00355779074923997 0.999613929426299 0.999099271995683 0.999874632432309 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Asp455Gly mmpL5_p.Asp455Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Asp608Asn mmpL5_p.Asp608Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 19 0 19 0 21 1035 12930 0 0 0.00355779074923997 0.998378503590456 0.997522432852902 0.998995996718269 0 0 0.161097615219079 0 0 0.176466911806965 0 0 0.161097615219079 0 0 2.68158658536076 0.393880160909475 174 1032 False False 0 0 2.40325373626413 0 0 0.00355779074923997 0.998378503590456 0.997522432852902 0.998995996718269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 45 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Asp608Tyr mmpL5_p.Asp608Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Asp681Glu mmpL5_p.Asp681Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Asp767Ala mmpL5_p.Asp767Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 12 0 12 0 17 1035 12934 0 0 0.00355779074923997 0.998687360049417 0.997899165449346 0.99923515877878 0 0 0.195064322969093 0 0 0.264648469397051 0 0 0.195064322969093 0 0 4.50467519547585 1 426 1032 False False 0 0 3.03338281190619 0 0 0.00355779074923997 0.998687360049417 0.997899165449346 0.99923515877878 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 901 1245 0 0 0.0040858359972341 0.99679743795036 0.991820638117455 0.999126741506926 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.35112512116886 0.269214471587408 79.5 299 False False 0 0 0 0 0 0 0 0 0 2.09854624946918 0 0 0.0040858359972341 0.99679743795036 0.991820638117455 0.999126741506926 42 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Asp767Asn mmpL5_p.Asp767Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 185 3915 850 9036 0.178743961352657 0.155858970758929 0.203471874618274 0.697706740792216 0.689714878366858 0.705609674607288 0.0451219512195121 0.0389725588843979 0.0519295097418612 NA NA NA 0 0 0.000941798745925558 NA NA NA NA NA NA False True 0.502339418526031 0.424294473021386 0.592354258368936 0 0 0.00433045460510758 0.697706740792216 0.689714878366858 0.705609674607288 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 146 509 755 740 0.16204217536071 0.138562552173681 0.187755030152494 0.592473979183346 0.564631499477992 0.619880096285225 0.222900763358778 0.191572789707371 0.256748791305036 NA NA NA 0 0 0.00722110897087369 NA NA NA NA NA NA False True 0 1 1 0 0 0 1 0.281138188110696 0.226255593075165 0.348328337055953 0 0 0.00487401629696828 0.592473979183346 0.564631499477992 0.619880096285225 9843 Not assoc w R 5) Not assoc w R No change yes 1 +Bedaquiline mmpL5 p.Gln140His mmpL5_p.Gln140His 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Gln333Glu mmpL5_p.Gln333Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 1035 12947 0 0 0.00355779074923997 0.999691143541039 0.99920939533685 0.999915840803364 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 18.9615575493326 1 426 1032 False False 0 0 18.9615575493326 0 0 0.00355779074923997 0.999691143541039 0.99920939533685 0.999915840803364 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 10 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Gln504* mmpL5_p.Gln504* 1 stop_gained (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations No change no D 1 +Bedaquiline mmpL5 p.Gln60* mmpL5_p.Gln60* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations No change no D 1 +Bedaquiline mmpL5 p.Gln702* mmpL5_p.Gln702* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations No change no D 1 +Bedaquiline mmpL5 p.Gln707Lys mmpL5_p.Gln707Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 7 1035 12944 0 0 0.00355779074923997 0.999459501196818 0.998886684999561 0.999782664716124 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 10.635803029904 1 426 1032 False False 0 0 8.6896253144418 0 0 0.00355779074923997 0.999459501196818 0.998886684999561 0.999782664716124 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 901 1247 0 0 0.0040858359972341 0.99839871897518 0.994227708034801 0.999806018576913 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.38115169544997 0.512872834309089 156.5 299 False False 0 0 0 0 0 0 0 0 0 7.38115169544997 0 0 0.0040858359972341 0.99839871897518 0.994227708034801 0.999806018576913 15 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Glu159Ala mmpL5_p.Glu159Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 0 0 0.975 0 0 0.975 0 0 54.0184755945099 1 186 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Glu174Gln mmpL5_p.Glu174Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Glu512Ala mmpL5_p.Glu512Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Glu512Gln mmpL5_p.Glu512Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 1035 12945 0 0 0.00355779074923997 0.999536715311559 0.998991899081557 0.999829964314549 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 10.6366244843314 1 426 1032 False False 0 0 10.6366244843314 0 0 0.00355779074923997 0.999536715311559 0.998991899081557 0.999829964314549 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Glu524Gly mmpL5_p.Glu524Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Glu552Gly mmpL5_p.Glu552Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 0 9 0 9 1035 12942 0 0 0.00355779074923997 0.999305072967338 0.998681223764717 0.999682187439592 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.336267116879942 0 0 6.34492522562988 1 426 1032 False False 0 0 6.34492522562988 0 0 0.00355779074923997 0.999305072967338 0.998681223764717 0.999682187439592 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 44 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Glu566Asp mmpL5_p.Glu566Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Glu723Asp mmpL5_p.Glu723Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 1035 12947 0 0 0.00355779074923997 0.999691143541039 0.99920939533685 0.999915840803364 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 18.9615575493326 1 426 1032 False False 0 0 18.9615575493326 0 0 0.00355779074923997 0.999691143541039 0.99920939533685 0.999915840803364 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Glu744Gln mmpL5_p.Glu744Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Glu830Asp mmpL5_p.Glu830Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Glu83Lys mmpL5_p.Glu83Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Gly102Asp mmpL5_p.Gly102Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 637 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Gly114Arg mmpL5_p.Gly114Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Gly131Arg mmpL5_p.Gly131Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 0 0 0.975 0 0 0.975 0 0 54.0184755945099 1 186 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 14 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Gly138Asp mmpL5_p.Gly138Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Gly181Asp mmpL5_p.Gly181Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Gly246Ser mmpL5_p.Gly246Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 43 1 42 1 44 1034 12907 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.996602578951432 0.995441775141606 0.997530376277694 0.0222222222222222 0.000562459715402258 0.117704331418294 0.0232558139534883 0.000588612931593182 0.122890482701339 0.0222222222222222 0.000562459715402258 0.117704331418294 0.297204568481164 0.00734786602049293 1.7528669535628 0.372421603604145 173 1032 False False 0.283695269913838 0.00702136879058417 1.66902865980699 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.996602578951432 0.995441775141606 0.997530376277694 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 67 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Gly257Arg mmpL5_p.Gly257Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Gly305Ser mmpL5_p.Gly305Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 0 0 0.975 0 0 0.975 0 0 54.0184755945099 1 186 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 2 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Gly336Ser mmpL5_p.Gly336Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 623 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Gly391Ser mmpL5_p.Gly391Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 19 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Gly396Cys mmpL5_p.Gly396Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Gly477Arg mmpL5_p.Gly477Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 30.2740898875531 1 426 1032 False False 0 0 30.2740898875531 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 13 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Gly559Ala mmpL5_p.Gly559Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Gly609Arg mmpL5_p.Gly609Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Gly661Arg mmpL5_p.Gly661Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Gly704Cys mmpL5_p.Gly704Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 30.2740898875531 1 426 1032 False False 0 0 30.2740898875531 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Gly748Asp mmpL5_p.Gly748Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Gly759Ser mmpL5_p.Gly759Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Gly79Ser mmpL5_p.Gly79Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Gly865Arg mmpL5_p.Gly865Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 620 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Gly875Arg mmpL5_p.Gly875Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Gly876Asp mmpL5_p.Gly876Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.His122Arg mmpL5_p.His122Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 24 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.His437Arg mmpL5_p.His437Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 7 1035 12944 0 0 0.00355779074923997 0.999459501196818 0.998886684999561 0.999782664716124 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 8.6896253144418 1 426 1032 False False 0 0 8.6896253144418 0 0 0.00355779074923997 0.999459501196818 0.998886684999561 0.999782664716124 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.His454Gln mmpL5_p.His454Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.His494Tyr mmpL5_p.His494Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.His540Arg mmpL5_p.His540Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.His590Pro mmpL5_p.His590Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 30.2740898875531 1 426 1032 False False 0 0 30.2740898875531 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.His656Tyr mmpL5_p.His656Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 645 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.His77Asn mmpL5_p.His77Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.His825fs mmpL5_p.His825fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations No change no D 1 +Bedaquiline mmpL5 p.Ile113Thr mmpL5_p.Ile113Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Ile215Val mmpL5_p.Ile215Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 30.2740898875531 1 426 1032 False False 0 0 30.2740898875531 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Ile282Leu mmpL5_p.Ile282Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Ile484Thr mmpL5_p.Ile484Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 630 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Ile529Met mmpL5_p.Ile529Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Ile555_Gly559del mmpL5_p.Ile555_Gly559del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Ile59Thr mmpL5_p.Ile59Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 7 1035 12944 0 0 0.00355779074923997 0.999459501196818 0.998886684999561 0.999782664716124 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 10.635803029904 1 426 1032 False False 0 0 8.6896253144418 0 0 0.00355779074923997 0.999459501196818 0.998886684999561 0.999782664716124 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Ile732Val mmpL5_p.Ile732Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 484.286119137424 1 426 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Ile735fs mmpL5_p.Ile735fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 648 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations No change no D 1 +Bedaquiline mmpL5 p.Ile787Met mmpL5_p.Ile787Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Ile829Val mmpL5_p.Ile829Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Ile841Val mmpL5_p.Ile841Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Ile910Val mmpL5_p.Ile910Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Ile948Ala mmpL5_p.Ile948Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 30.2740898875531 1 426 1032 False False 0 0 30.2740898875531 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Ile948Val mmpL5_p.Ile948Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 5468 55 5413 1029 12898 6 53 0.994202898550724 0.987425141013615 0.997869683284057 0.00409234808122924 0.00306690714551254 0.00534951637368332 0.0738852588497163 0.0695943099013417 0.0783552330104337 0.0100585223116313 0.00758619221008746 0.0130726597861556 0.00424612058982475 0.0032003129894333 0.00552336809159338 0.0897530636122913 0.036557476344815 0.266585095173431 4.02336803174607e-05 NA NA False True 0.70472166227322 0.302197070605684 2.01108850459891 0.901639344262295 0.798103808145629 0.963040005122148 0.00409234808122924 0.00306690714551254 0.00534951637368332 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 465 36 429 895 1245 6 4 0.993340732519422 0.9855622986936 0.997552360986006 0.00320256204963971 0.000873258493073058 0.00817936188254442 0.41822429906542 0.397215857831382 0.439457051059878 0.0774193548387096 0.0548102594931229 0.105571795083647 0.0281030444964871 0.0197589608181341 0.0386956373500319 0.0559440559440559 0.0112202338106906 0.251627215450981 5.4284219859591e-05 NA NA False True 0 0 1 0 0 1 1 0.479250334672021 0.0992047567785015 2.02846743853753 0.857142857142857 0.714606158086728 0.945716141621235 0.00320256204963971 0.000873258493073058 0.00817936188254442 38025 Not assoc w R Literature evidence (PMID 28031270; 34503982) 4) Not assoc w R - Interim DOWN from NotAwR to NotAwRI yes Lit. (PMID 28031270; 34503982) 3 +Bedaquiline mmpL5 p.Leu116Val mmpL5_p.Leu116Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Leu219Phe mmpL5_p.Leu219Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 2 4 1033 12947 0.00193236714975845 0.000234104356582827 0.00696277826632085 0.999691143541039 0.99920939533685 0.999915840803364 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.707598226178713 0 0 0.602364635616474 0 0 30.3283932835099 1 216 1032 False False 6.26669893514036 0.566095132941854 43.8078868219245 0 0 0.00356466672608257 0.999691143541039 0.99920939533685 0.999915840803364 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 899 1249 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 216 299 False False 0 0 0 0 0 0 0 Inf 0.260427478737382 Inf 0 0 0.00409490709625158 1 0.997050890854678 1 14 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Leu329Arg mmpL5_p.Leu329Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Leu335Val mmpL5_p.Leu335Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Leu523Pro mmpL5_p.Leu523Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Leu600Arg mmpL5_p.Leu600Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Leu630fs mmpL5_p.Leu630fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 632 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations New Uncertain no D 0 +Bedaquiline mmpL5 p.Leu653Met mmpL5_p.Leu653Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Leu691Arg mmpL5_p.Leu691Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Leu709Ile mmpL5_p.Leu709Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 1034 12950 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999922785885259 0.999569866411227 0.99999804510978 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 12.5241779497098 0.159396979672639 974.620016429296 0.142533667024192 158.5 1032 False False 12.5241779497098 0.159396979672639 974.620016429296 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Leu751Phe mmpL5_p.Leu751Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Leu810Phe mmpL5_p.Leu810Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Leu818Met mmpL5_p.Leu818Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Leu836Phe mmpL5_p.Leu836Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 17 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Leu95Arg mmpL5_p.Leu95Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Lys467Arg mmpL5_p.Lys467Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 10 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Lys467fs mmpL5_p.Lys467fs 1 frameshift (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 1035 12946 0 0 0.00355779074923997 0.999613929426299 0.999099271995683 0.999874632432309 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 13.6669955985752 1 426 1032 False False 0 0 13.6669955985752 0 0 0.00355779074923997 0.999613929426299 0.999099271995683 0.999874632432309 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 0 0 0.975 0 0 0.975 0 0 54.0184755945099 1 186 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 11 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations No change no D 1 +Bedaquiline mmpL5 p.Lys589fs mmpL5_p.Lys589fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations No change no D 1 +Bedaquiline mmpL5 p.Lys646Gln mmpL5_p.Lys646Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Lys649Thr mmpL5_p.Lys649Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Lys766_Asp770delinsAsn mmpL5_p.Lys766_Asp770delinsAsn 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Lys80Gln mmpL5_p.Lys80Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Met218Val mmpL5_p.Met218Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Met443Thr mmpL5_p.Met443Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Met503Arg mmpL5_p.Met503Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Met503Ile mmpL5_p.Met503Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Met560Leu mmpL5_p.Met560Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Met560Thr mmpL5_p.Met560Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 650 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 21 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Met638_Met641del mmpL5_p.Met638_Met641del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Met638Leu mmpL5_p.Met638Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 636 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Met645Ile mmpL5_p.Met645Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Met655Thr mmpL5_p.Met655Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 34 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Met666Ile mmpL5_p.Met666Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Met676Val mmpL5_p.Met676Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 634 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Met72Thr mmpL5_p.Met72Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Met892Ile mmpL5_p.Met892Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Met892Thr mmpL5_p.Met892Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Met892Val mmpL5_p.Met892Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Met903Ile mmpL5_p.Met903Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Met912Thr mmpL5_p.Met912Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 46 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Phe129Ser mmpL5_p.Phe129Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Phe696Leu mmpL5_p.Phe696Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 116 2 114 4 133 1031 12818 0.0038647342995169 0.00105398325986622 0.009865452176262 0.989730522739556 0.987841098442103 0.991394707245727 0.0291970802919708 0.00801135704752468 0.0730678323967123 0.0172413793103448 0.00209487394938755 0.0608948402594073 0.0148148148148148 0.00179920541379382 0.0524905689300874 0.218115609100345 0.0260503128711698 0.808350514784124 0.0119674852502232 78 1032 False False 0.373912472743449 0.100192188171844 0.983145550788132 0.00193610842207163 0.000234557774419548 0.0069762248687798 0.989730522739556 0.987841098442103 0.991394707245727 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 2 9 4 16 897 1233 0.00443951165371809 0.00121090206228936 0.0113275932937957 0.987189751801441 0.979280124416177 0.992660590415359 0.2 0.0573339970500327 0.436614002996668 0.181818181818181 0.0228311982999596 0.517755852360172 0.111111111111111 0.0137512156643644 0.347120438608672 0.30546265328874 0.0320549312025077 1.48158784648842 0.133412948287954 46 299 False False 0 0 0 0 0 0 0 0.343645484949832 0.083326860981055 1.07058358328479 0.00222469410456062 0.000269534419292234 0.00801304158128612 0.987189751801441 0.979280124416177 0.992660590415359 626 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Phe816Leu mmpL5_p.Phe816Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Phe82fs mmpL5_p.Phe82fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations No change no D 1 +Bedaquiline mmpL5 p.Phe82Leu mmpL5_p.Phe82Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Phe890Ser mmpL5_p.Phe890Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 635 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 219 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Phe916Ser mmpL5_p.Phe916Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Pro179Thr mmpL5_p.Pro179Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Pro180Leu mmpL5_p.Pro180Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 30.2740898875531 1 426 1032 False False 0 0 30.2740898875531 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Pro390fs mmpL5_p.Pro390fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations No change no D 1 +Bedaquiline mmpL5 p.Pro390Ser mmpL5_p.Pro390Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 651 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Pro445Leu mmpL5_p.Pro445Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Pro498fs mmpL5_p.Pro498fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 639 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 25 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations New Uncertain no D 0 +Bedaquiline mmpL5 p.Pro927Arg mmpL5_p.Pro927Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Pro947Ser mmpL5_p.Pro947Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Pro953Ser mmpL5_p.Pro953Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Ser125Cys mmpL5_p.Ser125Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 0 8 1035 12943 0 0 0.00355779074923997 0.999382287082078 0.998783224071471 0.999733278885799 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 7.3371961646121 1 426 1032 False False 0 0 7.3371961646121 0 0 0.00355779074923997 0.999382287082078 0.998783224071471 0.999733278885799 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 901 1244 0 0 0.0040858359972341 0.99599679743795 0.990682777281159 0.998698932354597 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.51093957896194 0.0787834413648395 45 299 False False 0 0 0 0 0 0 0 0 0 1.51093957896194 0 0 0.0040858359972341 0.99599679743795 0.990682777281159 0.998698932354597 43 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Ser439Ala mmpL5_p.Ser439Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Ser439Pro mmpL5_p.Ser439Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 30.2740898875531 1 426 1032 False False 0 0 30.2740898875531 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 901 1246 0 0 0.0040858359972341 0.99759807846277 0.992996755835892 0.999504391864096 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.35381326044578 0.269309251463633 81 299 False False 0 0 0 0 0 0 0 0 0 3.35381326044578 0 0 0.0040858359972341 0.99759807846277 0.992996755835892 0.999504391864096 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Ser452Asn mmpL5_p.Ser452Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Ser479fs mmpL5_p.Ser479fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations No change no D 1 +Bedaquiline mmpL5 p.Ser507Asn mmpL5_p.Ser507Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 0 0 0.975 0 0 0.975 0 0 54.0184755945099 1 186 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 8 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Ser541Arg mmpL5_p.Ser541Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 629 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Ser583Asn mmpL5_p.Ser583Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Ser599Leu mmpL5_p.Ser599Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 901 1247 0 0 0.0040858359972341 0.99839871897518 0.994227708034801 0.999806018576913 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.38115169544997 0.512872834309089 156.5 299 False False 0 0 0 0 0 0 0 0 0 7.38115169544997 0 0 0.0040858359972341 0.99839871897518 0.994227708034801 0.999806018576913 5 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Ser654Thr mmpL5_p.Ser654Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Ser65Arg mmpL5_p.Ser65Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Ser71Pro mmpL5_p.Ser71Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 1035 12947 0 0 0.00355779074923997 0.999691143541039 0.99920939533685 0.999915840803364 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 18.9615575493326 1 426 1032 False False 0 0 18.9615575493326 0 0 0.00355779074923997 0.999691143541039 0.99920939533685 0.999915840803364 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Ser728fs mmpL5_p.Ser728fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations No change no D 1 +Bedaquiline mmpL5 p.Ser782Ala mmpL5_p.Ser782Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Ser879Leu mmpL5_p.Ser879Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 641 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Ser894* mmpL5_p.Ser894* 1 stop_gained (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 1035 12946 0 0 0.00355779074923997 0.999613929426299 0.999099271995683 0.999874632432309 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 13.6669955985752 1 426 1032 False False 0 0 13.6669955985752 0 0 0.00355779074923997 0.999613929426299 0.999099271995683 0.999874632432309 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations No change no D 1 +Bedaquiline mmpL5 p.Thr10Ala mmpL5_p.Thr10Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Thr120Ala mmpL5_p.Thr120Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 625 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Thr234Met mmpL5_p.Thr234Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Thr327Ile mmpL5_p.Thr327Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 646 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Thr334fs mmpL5_p.Thr334fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations No change no D 1 +Bedaquiline mmpL5 p.Thr519Ala mmpL5_p.Thr519Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 626 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 217 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Thr606Ala mmpL5_p.Thr606Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Thr6Ala mmpL5_p.Thr6Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Thr794Ile mmpL5_p.Thr794Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 737 6801 298 6150 0.71207729468599 0.683432731159653 0.739510137643376 0.474866805652073 0.466234290480093 0.48351061993512 0.0977712921199257 0.0911566602529875 0.104698778523508 0 0 0.602364635616474 0 0 0.000542255433941289 0 0 31.3678436231052 1 NA NA False True 2.23642101585929 1.94326032540552 2.57838120326438 0 0 0.0123024880590161 0.474866805652073 0.466234290480093 0.48351061993512 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 635 760 266 489 0.704772475027747 0.673797790056955 0.734401542105758 0.391513210568454 0.36432674061483 0.419211668473279 0.455197132616487 0.428824083745921 0.48175925571071 NA NA NA 0 0 0.00484202815828394 NA NA NA NA NA NA False True 0 0 1 0 0 0 1 1.53598634744756 1.27445147276996 1.85257138052093 0 0 0.0137722505851113 0.391513210568454 0.36432674061483 0.419211668473279 20251 Not assoc w R Literature evidence (PMID 28031270; 34503982) 4) Not assoc w R - Interim DOWN from NotAwR to NotAwRI yes Lit. (PMID 28031270; 34503982) 3 +Bedaquiline mmpL5 p.Thr918fs mmpL5_p.Thr918fs 1 frameshift (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 1035 12946 0 0 0.00355779074923997 0.999613929426299 0.999099271995683 0.999874632432309 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 13.6669955985752 1 426 1032 False False 0 0 13.6669955985752 0 0 0.00355779074923997 0.999613929426299 0.999099271995683 0.999874632432309 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations No change no D 1 +Bedaquiline mmpL5 p.Trp130fs mmpL5_p.Trp130fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations No change no D 1 +Bedaquiline mmpL5 p.Trp39* mmpL5_p.Trp39* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations New Uncertain no D 0 +Bedaquiline mmpL5 p.Trp598Arg mmpL5_p.Trp598Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 33 0 33 1 33 1034 12918 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.997451934213574 0.996423412305545 0.998245399495595 0.0294117647058823 0.00074436423469026 0.153267669560317 0 0 0.105762810074579 0 0 0.105762810074579 0 0 1.48032805661516 0.171891563399646 167 1032 False False 0.378582732547916 0.00930057162859977 2.26644348621314 0 0 0.00356122541865182 0.997451934213574 0.996423412305545 0.998245399495595 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 900 1248 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 0.99919935948759 0.995547271980628 0.999979729742686 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 54.0784454070597 1 186 299 False False 0 0 0 0 0 0 0 1.38666666666666 0.0176530068458996 108.845447474822 0 0 0.00409036651757122 0.99919935948759 0.995547271980628 0.999979729742686 30 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Trp598Cys mmpL5_p.Trp598Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 638 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Trp598Gly mmpL5_p.Trp598Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Trp823Arg mmpL5_p.Trp823Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 627 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Trp833* mmpL5_p.Trp833* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations No change no D 1 +Bedaquiline mmpL5 p.Trp936Arg mmpL5_p.Trp936Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 30.2740898875531 1 426 1032 False False 0 0 30.2740898875531 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 12 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Trp938Arg mmpL5_p.Trp938Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Trp952Leu mmpL5_p.Trp952Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 26 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Tyr185* mmpL5_p.Tyr185* 1 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 647 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations No change no D 1 +Bedaquiline mmpL5 p.Tyr299Cys mmpL5_p.Tyr299Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Tyr300* mmpL5_p.Tyr300* 1 stop_gained (see "Genomic_coordinates" sheet) 1 156 0 156 0 169 1035 12782 0 0 0.00355779074923997 0.98695081460891 0.984844464528211 0.988833901541255 0 0 0.0215911889482308 0 0 0.0233692715913802 0 0 0.0215911889482308 0 0 0.296094399936944 9.08987960787605e-06 24 1032 True False 0 0 0.273093699173876 0 0 0.00355779074923997 0.98695081460891 0.984844464528211 0.988833901541255 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 0 0 0.975 0 0 0.975 0 0 54.0184755945099 1 186 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 368 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations No change no D 1 +Bedaquiline mmpL5 p.Tyr411Asp mmpL5_p.Tyr411Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Tyr415Cys mmpL5_p.Tyr415Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Tyr514Cys mmpL5_p.Tyr514Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Tyr586* mmpL5_p.Tyr586* 1 stop_gained (see "Genomic_coordinates" sheet) 1 7 0 7 0 7 1035 12944 0 0 0.00355779074923997 0.999459501196818 0.998886684999561 0.999782664716124 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 8.6896253144418 1 426 1032 False False 0 0 8.6896253144418 0 0 0.00355779074923997 0.999459501196818 0.998886684999561 0.999782664716124 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations No change no D 1 +Bedaquiline mmpL5 p.Val123Ile mmpL5_p.Val123Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Val149Ile mmpL5_p.Val149Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 633 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Val151Gly mmpL5_p.Val151Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 628 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Val182Ile mmpL5_p.Val182Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Val186Ile mmpL5_p.Val186Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Val214Leu mmpL5_p.Val214Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 1035 12946 0 0 0.00355779074923997 0.999613929426299 0.999099271995683 0.999874632432309 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 13.6669955985752 1 426 1032 False False 0 0 13.6669955985752 0 0 0.00355779074923997 0.999613929426299 0.999099271995683 0.999874632432309 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Val222Gly mmpL5_p.Val222Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Val247Ala mmpL5_p.Val247Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 34 0 34 1 34 1034 12917 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.997374720098834 0.996333348686749 0.998181253151538 0.0285714285714285 0.000723104376338095 0.149172079656431 0 0 0.102817924259012 0 0 0.102817924259012 0 0 1.43428967212147 0.175770717877799 168 1032 False False 0.367419501649789 0.00903414629988648 2.19508758566961 0 0 0.00356122541865182 0.997374720098834 0.996333348686749 0.998181253151538 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 900 1247 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 0.99839871897518 0.994227708034801 0.999806018576913 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.38935679925168 0.512960425922411 161 299 False False 0 0 0 0 0 0 0 0.692777777777777 0.0117351849678213 13.3292134004368 0 0 0.00409036651757122 0.99839871897518 0.994227708034801 0.999806018576913 19 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Val247fs mmpL5_p.Val247fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 642 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 220 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations New Uncertain no D 0 +Bedaquiline mmpL5 p.Val267Gly mmpL5_p.Val267Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Val268Met mmpL5_p.Val268Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Val337Met mmpL5_p.Val337Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 30.2740898875531 1 426 1032 False False 0 0 30.2740898875531 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Val344Leu mmpL5_p.Val344Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 37 1 36 1 38 1034 12913 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.997065863639873 0.99597487067054 0.997922819293648 0.0256410256410256 0.000648963895481945 0.134763921559497 0.027027027027027 0.000684031024694665 0.141603095611158 0.0256410256410256 0.000648963895481945 0.134763921559497 0.346899849559424 0.00854319414733345 2.06469029964777 0.52155139415495 178 1032 False False 0.328641962740507 0.00810512458435207 1.94943549036309 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.997065863639873 0.99597487067054 0.997922819293648 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 0 9 901 1240 0 0 0.0040858359972341 0.99279423538831 0.986365463514992 0.9966999266574 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.699606601465108 0.0127365706487545 21 299 False False 0 0 0 0 0 0 0 0 0 0.699606601465108 0 0 0.0040858359972341 0.99279423538831 0.986365463514992 0.9966999266574 225 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Val346Ala mmpL5_p.Val346Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 643 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Val360Met mmpL5_p.Val360Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Val376Ala mmpL5_p.Val376Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 631 1032 False False 0 0 30.2740898875531 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 901 1247 0 0 0.0040858359972341 0.99839871897518 0.994227708034801 0.999806018576913 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 218 299 False False 0 0 0 0 0 0 0 0 0 7.38115169544997 0 0 0.0040858359972341 0.99839871897518 0.994227708034801 0.999806018576913 2 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Val382Ala mmpL5_p.Val382Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Val41Ile mmpL5_p.Val41Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Val481Met mmpL5_p.Val481Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 0 0 0.975 0 0 0.975 0 0 54.0184755945099 1 186 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Val612Gly mmpL5_p.Val612Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 649 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Val612Ile mmpL5_p.Val612Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Val695Ile mmpL5_p.Val695Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 0 0 0.975 0 0 0.975 0 0 54.0184755945099 1 186 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Val820Leu mmpL5_p.Val820Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 0 0 0.975 0 0 0.975 0 0 54.0184755945099 1 186 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Val840Ile mmpL5_p.Val840Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 0 0 0.975 0 0 0.975 0 0 54.0184755945099 1 186 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 5 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpL5 p.Val846Ile mmpL5_p.Val846Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Val942Ile mmpL5_p.Val942Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Bedaquiline mmpL5 p.Val964Leu mmpL5_p.Val964Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Bedaquiline mmpS5 c.102C>T mmpS5_c.102C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpS5 c.126G>A mmpS5_c.126G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 30.2740898875531 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 54.0184755945099 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpS5 c.-14A>C mmpS5_c.-14A>C 1 upstream_gene_variant 778919 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Bedaquiline mmpS5 c.168G>C mmpS5_c.168G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpS5 c.189C>T mmpS5_c.189C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpS5 c.-19G>A mmpS5_c.-19G>A 1 upstream_gene_variant 778924 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Bedaquiline mmpS5 c.204C>T mmpS5_c.204C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpS5 c.-20T>C mmpS5_c.-20T>C 1 upstream_gene_variant 778925 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpS5 c.216G>A mmpS5_c.216G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpS5 c.-22C>T mmpS5_c.-22C>T 1 upstream_gene_variant 778927 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 653 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpS5 c.306C>T mmpS5_c.306C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 30.2740898875531 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 54.0184755945099 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpS5 c.315G>C mmpS5_c.315G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpS5 c.-31C>G mmpS5_c.-31C>G 1 upstream_gene_variant 778936 1 3 0 3 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 30.2740898875531 1 426 1032 False False 0 0 30.2740898875531 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpS5 c.321C>A mmpS5_c.321C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 901 1247 0 0 0.0040858359972341 0.99839871897518 0.994227708034801 0.999806018576913 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 7.38115169544997 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpS5 c.333C>A mmpS5_c.333C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpS5 c.34C>T mmpS5_c.34C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpS5 c.-34C>T mmpS5_c.-34C>T 1 upstream_gene_variant 778939 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpS5 c.-36A>G mmpS5_c.-36A>G 1 upstream_gene_variant 778941 1 3 0 3 0 8 1035 12943 0 0 0.00355779074923997 0.999382287082078 0.998783224071471 0.999733278885799 0 0 0.369416647552819 0 0 0.707598226178713 0 0 0.369416647552819 0 0 30.2628244697427 1 216 1032 False False 0 0 7.3371961646121 0 0 0.00355779074923997 0.999382287082078 0.998783224071471 0.999733278885799 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 901 1247 0 0 0.0040858359972341 0.99839871897518 0.994227708034801 0.999806018576913 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 224 299 False False 0 0 0 0 0 0 0 0 0 7.38115169544997 0 0 0.0040858359972341 0.99839871897518 0.994227708034801 0.999806018576913 27 3) Uncertain significance No change no 1 +Bedaquiline mmpS5 c.387C>T mmpS5_c.387C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpS5 c.393G>T mmpS5_c.393G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpS5 c.399C>T mmpS5_c.399C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpS5 c.39C>G mmpS5_c.39C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpS5 c.-39C>T mmpS5_c.-39C>T 1 upstream_gene_variant 778944 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 662 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 226 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpS5 c.400C>T mmpS5_c.400C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpS5 c.402G>A mmpS5_c.402G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 30.2740898875531 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpS5 c.42C>A mmpS5_c.42C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 54.0184755945099 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpS5 c.42C>T mmpS5_c.42C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpS5 c.-519_-82del mmpS5_c.-519_-82del 1 upstream_gene_variant 778986 0 0 0 0 1 6 1034 12945 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999536715311559 0.998991899081557 0.999829964314549 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA 0 0 0.4592581264399 NA NA NA NA 652 1032 False False 2.08655705996131 0.04531897968609 17.2208772568668 0 0 0.00356122541865182 0.999536715311559 0.998991899081557 0.999829964314549 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 222 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0 0 0.00409036651757122 1 0.997050890854678 1 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpS5 c.-51G>A mmpS5_c.-51G>A 1 upstream_gene_variant 778956 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpS5 c.-55G>C mmpS5_c.-55G>C 1 upstream_gene_variant 778960 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpS5 c.-56C>T mmpS5_c.-56C>T 1 upstream_gene_variant 778961 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Bedaquiline mmpS5 c.-60G>A mmpS5_c.-60G>A 1 upstream_gene_variant 778965 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpS5 c.-63T>G mmpS5_c.-63T>G 1 upstream_gene_variant 778968 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpS5 c.-65_-64insGAA mmpS5_c.-65_-64insGAA 1 upstream_gene_variant 778969 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpS5 c.-65A>G mmpS5_c.-65A>G 1 upstream_gene_variant 778970 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline mmpS5 c.66C>T mmpS5_c.66C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpS5 c.6T>C mmpS5_c.6T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpS5 c.-71C>A mmpS5_c.-71C>A 1 upstream_gene_variant 778976 2 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 225 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0 0 0.00409036651757122 1 0.997050890854678 1 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpS5 c.-71C>T mmpS5_c.-71C>T 1 upstream_gene_variant 778976 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpS5 c.-74G>T mmpS5_c.-74G>T 1 upstream_gene_variant 778979 0 0 0 0 37 93 998 12858 0.0357487922705314 0.025292958564011 0.0489403836040784 0.992819087329163 0.991210014296021 0.994200278133138 0.284615384615384 0.208962181862092 0.370356167663042 NA NA NA 0 0 0.0388889985342758 NA NA NA NA NA NA False True 5.12579998707091 3.38342552092529 7.62237797591021 0 0 0.00368944919367051 0.992819087329163 0.991210014296021 0.994200278133138 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 36 3 865 1246 0.0399556048834628 0.0281385598343308 0.0548886684223489 0.99759807846277 0.992996755835892 0.999504391864096 0.923076923076923 0.791298078773556 0.983846699689341 NA NA NA 0 0 0.707598226178713 NA NA NA NA NA NA False True 0 0 1 0 0 0 1 17.2855491329479 5.42968616542096 87.8361878707306 0 0 0.00425552002898375 0.99759807846277 0.992996755835892 0.999504391864096 276 Literature evidence (PMID 28031270; 34503982) 4) Not assoc w R - Interim UP from Uncertain to NotAwRI yes Lit. (PMID 28031270; 34503982) 4 +Bedaquiline mmpS5 c.-75T>G mmpS5_c.-75T>G 1 upstream_gene_variant 778980 1 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpS5 c.-77A>G mmpS5_c.-77A>G 1 upstream_gene_variant 778982 1 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpS5 c.-79_-78insT mmpS5_c.-79_-78insT 1 upstream_gene_variant 778983 1 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpS5 c.81G>A mmpS5_c.81G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 54.0184755945099 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpS5 c.-82G>T mmpS5_c.-82G>T 1 upstream_gene_variant 778987 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpS5 c.-83_-82insA mmpS5_c.-83_-82insA 1 upstream_gene_variant 778987 1 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpS5 c.-84A>C mmpS5_c.-84A>C 1 upstream_gene_variant 778989 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 0 0 0.975 0 0 0.975 0 0 54.0184755945099 1 186 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpS5 c.-9_-8delCG mmpS5_c.-9_-8delCG 1 upstream_gene_variant 778912 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpS5 c.90T>C mmpS5_c.90T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpS5 c.9A>G mmpS5_c.9A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mmpS5 c.-9C>T mmpS5_c.-9C>T 1 upstream_gene_variant 778914 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpS5 LoF mmpS5_LoF 1 LoF (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 66.5980571122582 1 426 1032 False False 0 0 30.2740898875531 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpS5 p.Ala133Thr mmpS5_p.Ala133Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 0 0 0.975 0 0 0.975 0 0 54.0184755945099 1 186 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 NA 3) Uncertain significance No change no 1 +Bedaquiline mmpS5 p.Ala142Ser mmpS5_p.Ala142Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpS5 p.Ala45fs mmpS5_p.Ala45fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 659 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpS5 p.Ala8Ser mmpS5_p.Ala8Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 657 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpS5 p.Ala8Val mmpS5_p.Ala8Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 658 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 10 3) Uncertain significance No change no 1 +Bedaquiline mmpS5 p.Arg29Cys mmpS5_p.Arg29Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpS5 p.Arg29Leu mmpS5_p.Arg29Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpS5 p.Asp119fs mmpS5_p.Asp119fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline mmpS5 p.Asp82Glu mmpS5_p.Asp82Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpS5 p.Cys114Ser mmpS5_p.Cys114Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpS5 p.Glu59Lys mmpS5_p.Glu59Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpS5 p.Gly109Asp mmpS5_p.Gly109Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 655 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Bedaquiline mmpS5 p.Gly109Ser mmpS5_p.Gly109Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 656 1032 False False 0 0 30.2740898875531 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 33 3) Uncertain significance No change no 1 +Bedaquiline mmpS5 p.Gly130Arg mmpS5_p.Gly130Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpS5 p.Gly130Asp mmpS5_p.Gly130Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 0 0 0.975 0 0 0.975 0 0 54.0184755945099 1 186 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 3 3) Uncertain significance No change no 1 +Bedaquiline mmpS5 p.Ile116Leu mmpS5_p.Ile116Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpS5 p.Ile14Thr mmpS5_p.Ile14Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpS5 p.Ile69Val mmpS5_p.Ile69Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpS5 p.Lys123fs mmpS5_p.Lys123fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpS5 p.Lys42Arg mmpS5_p.Lys42Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Bedaquiline mmpS5 p.Lys6Thr mmpS5_p.Lys6Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpS5 p.Pro101Arg mmpS5_p.Pro101Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpS5 p.Pro53Leu mmpS5_p.Pro53Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpS5 p.Pro78Leu mmpS5_p.Pro78Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 661 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 25 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpS5 p.Ser34Phe mmpS5_p.Ser34Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Bedaquiline mmpS5 p.Ser98Pro mmpS5_p.Ser98Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Bedaquiline mmpS5 p.Thr113Asn mmpS5_p.Thr113Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpS5 p.Thr24Ala mmpS5_p.Thr24Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpS5 p.Thr24Met mmpS5_p.Thr24Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 5 1035 12946 0 0 0.00355779074923997 0.999613929426299 0.999099271995683 0.999874632432309 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 654 1032 False False 0 0 13.6669955985752 0 0 0.00355779074923997 0.999613929426299 0.999099271995683 0.999874632432309 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 901 1247 0 0 0.0040858359972341 0.99839871897518 0.994227708034801 0.999806018576913 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 223 299 False False 0 0 0 0 0 0 0 0 0 7.38115169544997 0 0 0.0040858359972341 0.99839871897518 0.994227708034801 0.999806018576913 10 3) Uncertain significance No change no 1 +Bedaquiline mmpS5 p.Thr4Ile mmpS5_p.Thr4Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline mmpS5 p.Thr4Pro mmpS5_p.Thr4Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Bedaquiline mmpS5 p.Val131_Asp132insThrGlyVal mmpS5_p.Val131_Asp132insThrGlyVal 1 inframe_insertion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline mmpS5 p.Val55Met mmpS5_p.Val55Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 21 3) Uncertain significance No change no 1 +Bedaquiline mmpS5 p.Val56Met mmpS5_p.Val56Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 660 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline mmpS5 p.Val67Gly mmpS5_p.Val67Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 30.2740898875531 1 426 1032 False False 0 0 30.2740898875531 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Bedaquiline mmpS5 p.Val67Ile mmpS5_p.Val67Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA c.-108C>T mtrA_c.-108C>T 2 upstream_gene_variant 3627457 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1013 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA c.-111C>G mtrA_c.-111C>G 2 upstream_gene_variant 3627460 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1014 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA c.111C>T mtrA_c.111C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrA c.-114G>C mtrA_c.-114G>C 2 upstream_gene_variant 3627463 0 0 0 0 9 4 1026 12947 0.00869565217391304 0.003983694112966 0.0164426238532791 0.999691143541039 0.99920939533685 0.999915840803364 0.692307692307692 0.385738338249294 0.909079605427903 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1021 1032 False False 28.3925438596491 7.90262443322765 126.076375520692 0 0 0.00358894337008483 0.999691143541039 0.99920939533685 0.999915840803364 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 7 3 894 1246 0.00776914539400666 0.00312913909316045 0.0159415364957336 0.99759807846277 0.992996755835892 0.999504391864096 0.7 0.347547149940002 0.933260488822265 NA NA NA 0 0 0.707598226178713 NA NA NA NA 296 299 False False 0 0 0 0 0 0 0 3.25205070842654 0.739544050870348 19.5303514631629 0 0 0.004117762043712 0.99759807846277 0.992996755835892 0.999504391864096 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA c.-123G>A mtrA_c.-123G>A 2 upstream_gene_variant 3627472 NA 0 0 0 2 0 1033 12951 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1004 1032 False False Inf 2.35115346086273 Inf 0 0 0.00356466672608257 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 292 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0 0 0.00409036651757122 1 0.997050890854678 1 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA c.126G>A mtrA_c.126G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrA c.-129G>C mtrA_c.-129G>C 2 upstream_gene_variant 3627478 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA c.-145G>A mtrA_c.-145G>A 2 upstream_gene_variant 3627494 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 996 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA c.-14G>A mtrA_c.-14G>A 2 upstream_gene_variant 3627363 0 0 0 0 1 1 1034 12950 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999922785885259 0.999569866411227 0.99999804510978 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1030 1032 False False 12.5241779497098 0.159396979672639 974.620016429296 0 0 0.00356122541865182 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 900 1248 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 0.99919935948759 0.995547271980628 0.999979729742686 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 298 299 False False 0 0 0 0 0 0 0 1.38666666666666 0.0176530068458996 108.845447474822 0 0 0.00409036651757122 0.99919935948759 0.995547271980628 0.999979729742686 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA c.-153G>A mtrA_c.-153G>A 2 upstream_gene_variant 3627502 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 986 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA c.-158G>C mtrA_c.-158G>C 2 upstream_gene_variant 3627507 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA c.-162C>G mtrA_c.-162C>G 2 upstream_gene_variant 3627511 1 1 0 1 0 102 1035 12849 0 0 0.00355779074923997 0.992124160296502 0.990447333261544 0.99357376209849 0 0 0.035519326657884 0 0 0.975 0 0 0.035519326657884 0 0 480.574539016003 1 426 1032 False False 0 0 0.458070448712648 0 0 0.00355779074923997 0.992124160296502 0.990447333261544 0.99357376209849 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 82 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA c.-173A>C mtrA_c.-173A>C 2 upstream_gene_variant 3627522 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1001 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA c.-184G>A mtrA_c.-184G>A 2 upstream_gene_variant 3627533 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1029 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA c.-204C>T mtrA_c.-204C>T 2 upstream_gene_variant 3627553 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA c.-20delT mtrA_c.-20delT 2 upstream_gene_variant 3627368 1 0 0 0 0 13 1035 12938 0 0 0.00355779074923997 0.998996216508377 0.998284111345339 0.999465422742454 0 0 0.24705263800047 NA NA NA 0 0 0.24705263800047 NA NA NA NA 991 1032 False False 0 0 4.10826345921427 0 0 0.00355779074923997 0.998996216508377 0.998284111345339 0.999465422742454 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 290 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 16 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA c.-211C>T mtrA_c.-211C>T 2 upstream_gene_variant 3627560 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1005 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA c.21G>A mtrA_c.21G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrA c.240G>A mtrA_c.240G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrA c.-245A>C mtrA_c.-245A>C 2 upstream_gene_variant 3627594 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1015 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA c.-246G>A mtrA_c.-246G>A 2 upstream_gene_variant 3627595 1 6 0 6 0 6 1035 12945 0 0 0.00355779074923997 0.999536715311559 0.998991899081557 0.999829964314549 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 10.6366244843314 1 426 1032 False False 0 0 10.6366244843314 0 0 0.00355779074923997 0.999536715311559 0.998991899081557 0.999829964314549 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 18 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA c.249C>T mtrA_c.249C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrA c.-250G>A mtrA_c.-250G>A 2 upstream_gene_variant 3627599 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 990 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA c.-253C>G mtrA_c.-253C>G 2 upstream_gene_variant 3627602 1 0 0 0 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1022 1032 False False 0 0 30.2740898875531 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA c.-253C>T mtrA_c.-253C>T 2 upstream_gene_variant 3627602 1 0 0 0 1 5 1034 12946 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999613929426299 0.999099271995683 0.999874632432309 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA 0 0 0.521823750104981 NA NA NA NA 983 1032 False False 2.50406189555125 0.0528921651376963 22.4053576430098 0 0 0.00356122541865182 0.999613929426299 0.999099271995683 0.999874632432309 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 289 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0 0 0.00409036651757122 1 0.997050890854678 1 52 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA c.-260G>A mtrA_c.-260G>A 2 upstream_gene_variant 3627609 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 998 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA c.-269G>A mtrA_c.-269G>A 2 upstream_gene_variant 3627618 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1031 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA c.-274G>A mtrA_c.-274G>A 2 upstream_gene_variant 3627623 1 0 0 0 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1002 1032 False False 0 0 30.2740898875531 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA c.277C>T mtrA_c.277C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrA c.-277C>T mtrA_c.-277C>T 2 upstream_gene_variant 3627626 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1026 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA c.-290C>T mtrA_c.-290C>T 2 upstream_gene_variant 3627639 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1007 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA c.-306G>C mtrA_c.-306G>C 2 upstream_gene_variant 3627655 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 987 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA c.-312T>C mtrA_c.-312T>C 2 upstream_gene_variant 3627661 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 988 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA c.321C>T mtrA_c.321C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 32 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrA c.-322C>T mtrA_c.-322C>T 2 upstream_gene_variant 3627671 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 994 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA c.324G>A mtrA_c.324G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrA c.330G>A mtrA_c.330G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 54.0184755945099 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrA c.-34_-33delTG mtrA_c.-34_-33delTG 2 upstream_gene_variant 3627381 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 982 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA c.-341T>A mtrA_c.-341T>A 2 upstream_gene_variant 3627690 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1011 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 293 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA c.-343A>G mtrA_c.-343A>G 2 upstream_gene_variant 3627692 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1019 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA c.-35G>A mtrA_c.-35G>A 2 upstream_gene_variant 3627384 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1010 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA c.-36T>G mtrA_c.-36T>G 2 upstream_gene_variant 3627385 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1008 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA c.-370G>A mtrA_c.-370G>A 2 upstream_gene_variant 3627719 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1003 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA c.381C>T mtrA_c.381C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrA c.39C>T mtrA_c.39C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 1033 12951 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 2.35115346086273 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 899 1249 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.260427478737382 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrA c.-39C>T mtrA_c.-39C>T 2 upstream_gene_variant 3627388 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 999 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA c.-40C>T mtrA_c.-40C>T 2 upstream_gene_variant 3627389 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1012 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA c.432G>A mtrA_c.432G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrA c.441C>T mtrA_c.441C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 1 1033 12950 0.00193236714975845 0.000234104356582827 0.00696277826632085 0.999922785885259 0.999569866411227 0.99999804510978 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 25.0726040658276 1.30341687247419 1463.2013999217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 899 1249 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.260427478737382 Inf NA NA NA NA NA NA 18 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrA c.468G>C mtrA_c.468G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrA c.477C>T mtrA_c.477C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrA c.480C>T mtrA_c.480C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrA c.489C>A mtrA_c.489C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrA c.525T>C mtrA_c.525T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrA c.534G>A mtrA_c.534G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrA c.576G>A mtrA_c.576G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrA c.57G>A mtrA_c.57G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 30.2740898875531 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 21 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrA c.-57T>G mtrA_c.-57T>G 2 upstream_gene_variant 3627406 1 0 0 0 0 4 1035 12947 0 0 0.00355779074923997 0.999691143541039 0.99920939533685 0.999915840803364 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1020 1032 False False 0 0 18.9615575493326 0 0 0.00355779074923997 0.999691143541039 0.99920939533685 0.999915840803364 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA c.594C>A mtrA_c.594C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrA c.601C>T mtrA_c.601C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrA c.-60C>T mtrA_c.-60C>T 2 upstream_gene_variant 3627409 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 992 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA c.-61G>A mtrA_c.-61G>A 2 upstream_gene_variant 3627410 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 989 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA c.651C>T mtrA_c.651C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrA c.-67G>A mtrA_c.-67G>A 2 upstream_gene_variant 3627416 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 995 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA c.-69G>C mtrA_c.-69G>C 2 upstream_gene_variant 3627418 0 0 0 0 5 1 1030 12950 0.00483091787439613 0.00157039035246783 0.0112374718131471 0.999922785885259 0.999569866411227 0.99999804510978 0.833333333333333 0.358765421002325 0.99578925548551 NA NA NA 0 0 0.975 NA NA NA NA 1018 1032 False False 62.8640776699029 7.01942689733694 2917.25851196433 0 0 0.00357503066948213 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 5 1 896 1248 0.00554938956714761 0.0018042535136792 0.0129025590758184 0.99919935948759 0.995547271980628 0.999979729742686 0.833333333333333 0.358765421002325 0.99578925548551 NA NA NA 0 0 0.975 NA NA NA NA 295 299 False False 0 0 0 0 0 0 0 6.96428571428571 0.776780780206836 329.119228994236 0 0 0.00410858951843322 0.99919935948759 0.995547271980628 0.999979729742686 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA c.-80T>C mtrA_c.-80T>C 2 upstream_gene_variant 3627429 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1000 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA c.81G>A mtrA_c.81G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrA c.-82C>A mtrA_c.-82C>A 2 upstream_gene_variant 3627431 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1016 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA c.-83A>G mtrA_c.-83A>G 2 upstream_gene_variant 3627432 1 0 0 0 0 4 1035 12947 0 0 0.00355779074923997 0.999691143541039 0.99920939533685 0.999915840803364 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1017 1032 False False 0 0 18.9615575493326 0 0 0.00355779074923997 0.999691143541039 0.99920939533685 0.999915840803364 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 294 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 5 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA p.Ala134Val mtrA_p.Ala134Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 984 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA p.Ala225Val mtrA_p.Ala225Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 985 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA p.Ala44Ser mtrA_p.Ala44Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1023 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA p.Arg5Lys mtrA_p.Arg5Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1032 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA p.Arg5Thr mtrA_p.Arg5Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 5 1035 12946 0 0 0.00355779074923997 0.999613929426299 0.999099271995683 0.999874632432309 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1009 1032 False False 0 0 13.6669955985752 0 0 0.00355779074923997 0.999613929426299 0.999099271995683 0.999874632432309 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA p.Glu129Asp mtrA_p.Glu129Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1024 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA p.Glu47Gly mtrA_p.Glu47Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 6 1035 12945 0 0 0.00355779074923997 0.999536715311559 0.998991899081557 0.999829964314549 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 997 1032 False False 0 0 10.6366244843314 0 0 0.00355779074923997 0.999536715311559 0.998991899081557 0.999829964314549 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 901 1246 0 0 0.0040858359972341 0.99759807846277 0.992996755835892 0.999504391864096 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 291 299 False False 0 0 0 0 0 0 0 0 0 3.35381326044578 0 0 0.0040858359972341 0.99759807846277 0.992996755835892 0.999504391864096 19 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA p.Leu165Met mtrA_p.Leu165Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1025 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA p.Pro188Ala mtrA_p.Pro188Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1006 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA p.Pro50Ala mtrA_p.Pro50Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1027 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA p.Ser153Pro mtrA_p.Ser153Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1028 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 297 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA p.Val140Leu mtrA_p.Val140Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrA p.Val205Ile mtrA_p.Val205Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 993 1032 False False 0 0 30.2740898875531 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB c.1033C>A mtrB_c.1033C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 21 1035 12930 0 0 0.00355779074923997 0.998378503590456 0.997522432852902 0.998995996718269 0 0 0.161097615219079 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.40325373626413 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 45 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.1053C>T mtrB_c.1053C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.111G>T mtrB_c.111G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.1197G>C mtrB_c.1197G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.1200C>T mtrB_c.1200C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.126C>T mtrB_c.126C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.1272C>G mtrB_c.1272C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.1293A>G mtrB_c.1293A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.1314C>T mtrB_c.1314C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.132G>A mtrB_c.132G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.133C>T mtrB_c.133C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.1350C>T mtrB_c.1350C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 2 1033 12949 0.00193236714975845 0.000234104356582827 0.00696277826632085 0.999845571770519 0.999442264649511 0.999981297477798 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 12.5353339787028 0.907371535939867 172.888916289171 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 899 1249 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.260427478737382 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.135G>T mtrB_c.135G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.1365G>A mtrB_c.1365G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.1386G>A mtrB_c.1386G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.138C>T mtrB_c.138C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.141T>A mtrB_c.141T>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.1437C>T mtrB_c.1437C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.1452T>C mtrB_c.1452T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.145C>T mtrB_c.145C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.1479A>G mtrB_c.1479A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 30.2740898875531 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.147G>A mtrB_c.147G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 68 291 967 12660 0.0657004830917874 0.0513766576419421 0.0825508763899778 0.977530692610609 0.974829729313011 0.980013994620575 0.189415041782729 0.15019644915656 0.233844011347041 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.05930766852525 2.29499963976454 4.03090459229062 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 65 35 836 1214 0.0721420643729189 0.0561157093023131 0.0910300456594468 0.971977582065652 0.961241629010643 0.980405430778497 0.65 0.54815063817603 0.742706221468548 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.69685577580314 1.74262209876183 4.23112238792929 NA NA NA NA NA NA 1301 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.-14A>C mtrB_c.-14A>C 2 upstream_gene_variant 3626627 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 949 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB c.1515C>T mtrB_c.1515C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.1524C>T mtrB_c.1524C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.1533C>T mtrB_c.1533C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.1582C>T mtrB_c.1582C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 30.2740898875531 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.1653G>T mtrB_c.1653G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.1662G>A mtrB_c.1662G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.1677A>G mtrB_c.1677A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.174C>T mtrB_c.174C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.186C>T mtrB_c.186C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 30.2740898875531 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.198C>T mtrB_c.198C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 9 1035 12942 0 0 0.00355779074923997 0.999305072967338 0.998681223764717 0.999682187439592 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 6.34492522562988 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.207C>T mtrB_c.207C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.-20G>A mtrB_c.-20G>A 2 upstream_gene_variant 3626633 1 0 0 0 0 8 1035 12943 0 0 0.00355779074923997 0.999382287082078 0.998783224071471 0.999733278885799 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 959 1032 False False 0 0 7.3371961646121 0 0 0.00355779074923997 0.999382287082078 0.998783224071471 0.999733278885799 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 22 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB c.210C>T mtrB_c.210C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.216C>T mtrB_c.216C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.-24C>T mtrB_c.-24C>T 2 upstream_gene_variant 3626637 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 931 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB c.276C>G mtrB_c.276C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.309C>T mtrB_c.309C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 13 1031 12938 0.0038647342995169 0.00105398325986622 0.009865452176262 0.998996216508377 0.998284111345339 0.999465422742454 0.235294117647058 0.0681077404373566 0.49899327320458 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.86122509885846 0.915346522787012 12.5263527816924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 4 5 897 1244 0.00443951165371809 0.00121090206228936 0.0113275932937957 0.99599679743795 0.990682777281159 0.998698932354597 0.444444444444444 0.136995662265166 0.787991493221131 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.10947603121516 0.219506455571604 5.17001468240112 NA NA NA NA NA NA 138 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.330T>G mtrB_c.330T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.345C>T mtrB_c.345C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.354T>C mtrB_c.354T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.363T>G mtrB_c.363T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 7 1035 12944 0 0 0.00355779074923997 0.999459501196818 0.998886684999561 0.999782664716124 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.6896253144418 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 39 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.369C>G mtrB_c.369C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.390G>A mtrB_c.390G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 8 1035 12943 0 0 0.00355779074923997 0.999382287082078 0.998783224071471 0.999733278885799 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.3371961646121 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 901 1247 0 0 0.0040858359972341 0.99839871897518 0.994227708034801 0.999806018576913 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 7.38115169544997 NA NA NA NA NA NA 18 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.405T>C mtrB_c.405T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 30.2740898875531 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.408T>C mtrB_c.408T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.420T>G mtrB_c.420T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.-44G>C mtrB_c.-44G>C 2 upstream_gene_variant 3626657 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 970 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB c.450G>A mtrB_c.450G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.453C>T mtrB_c.453C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 30.2740898875531 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.45C>T mtrB_c.45C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.489C>A mtrB_c.489C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.492C>G mtrB_c.492C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.516C>G mtrB_c.516C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.51C>G mtrB_c.51C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.534G>T mtrB_c.534G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 1032 12951 0.00289855072463768 0.000598150191171612 0.00844722324607505 1 0.999715206999795 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 5.17684059997845 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 898 1249 0.00332963374028856 0.000687177581788976 0.00969950356574711 1 0.997050890854678 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.573338395820229 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.573C>T mtrB_c.573C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 30.2740898875531 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.589C>T mtrB_c.589C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 1035 12945 0 0 0.00355779074923997 0.999536715311559 0.998991899081557 0.999829964314549 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 10.6366244843314 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 14 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.-5C>T mtrB_c.-5C>T 2 upstream_gene_variant 3626618 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 939 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB c.603G>A mtrB_c.603G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 54.0184755945099 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.606G>T mtrB_c.606G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.61C>A mtrB_c.61C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.667C>T mtrB_c.667C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.66C>T mtrB_c.66C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 20 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.673C>T mtrB_c.673C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 7 1033 12944 0.00193236714975845 0.000234104356582827 0.00696277826632085 0.999459501196818 0.998886684999561 0.999782664716124 0.222222222222222 0.0281449734778982 0.600093573716312 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.58014105932789 0.362385311109646 18.8271057397639 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.684C>T mtrB_c.684C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.693G>A mtrB_c.693G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.69C>T mtrB_c.69C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.75G>T mtrB_c.75G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.78G>A mtrB_c.78G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.801C>T mtrB_c.801C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 12 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.813G>A mtrB_c.813G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 54.0184755945099 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.90A>G mtrB_c.90A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.954C>T mtrB_c.954C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.958T>C mtrB_c.958T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB c.978C>T mtrB_c.978C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline mtrB LoF mtrB_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Ala144Gly mtrB_p.Ala144Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 10 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Ala227Ser mtrB_p.Ala227Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 1035 12947 0 0 0.00355779074923997 0.999691143541039 0.99920939533685 0.999915840803364 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 946 1032 False False 0 0 18.9615575493326 0 0 0.00355779074923997 0.999691143541039 0.99920939533685 0.999915840803364 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Ala33Val mtrB_p.Ala33Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 975 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Ala438Thr mtrB_p.Ala438Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 977 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Arg263Gly mtrB_p.Arg263Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 928 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Arg434Trp mtrB_p.Arg434Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 954 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Arg477Trp mtrB_p.Arg477Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 955 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 286 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Asn545fs mtrB_p.Asn545fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Asp136Gly mtrB_p.Asp136Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Asp267Gly mtrB_p.Asp267Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 957 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Glu204Asp mtrB_p.Glu204Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 951 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Glu389Asp mtrB_p.Glu389Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 934 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Glu429Gly mtrB_p.Glu429Gly 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 3 1032 12948 0.00289855072463768 0.000598150191171612 0.00844722324607505 0.999768357655779 0.999323193486146 0.999952227231941 0.5 0.118117248757025 0.881882751242974 NA NA NA 0 0 0.707598226178713 NA NA NA NA 963 1032 False False 12.5465116279069 1.67758125669166 93.6628178648886 0 0 0.00356811469079427 0.999768357655779 0.999323193486146 0.999952227231941 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 898 1249 0.00332963374028856 0.000687177581788976 0.00969950356574711 1 0.997050890854678 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 287 299 False False 0 0 0 0 0 0 0 Inf 0.573338395820229 Inf 0 0 0.00409945776680859 1 0.997050890854678 1 8 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Glu460Asp mtrB_p.Glu460Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 960 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Glu460Gly mtrB_p.Glu460Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 1035 12947 0 0 0.00355779074923997 0.999691143541039 0.99920939533685 0.999915840803364 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 18.9615575493326 1 426 1032 False False 0 0 18.9615575493326 0 0 0.00355779074923997 0.999691143541039 0.99920939533685 0.999915840803364 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Glu95Gly mtrB_p.Glu95Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 956 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Gly174Ala mtrB_p.Gly174Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 29 1035 12922 0 0 0.00355779074923997 0.997760790672535 0.996785692633168 0.998499869321082 0 0 0.119444869069502 NA NA NA 0 0 0.119444869069502 NA NA NA NA 964 1032 False False 0 0 1.69663891236676 0 0 0.00355779074923997 0.997760790672535 0.996785692633168 0.998499869321082 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 35 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Gly385Cys mtrB_p.Gly385Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 1035 12947 0 0 0.00355779074923997 0.999691143541039 0.99920939533685 0.999915840803364 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 961 1032 False False 0 0 18.9615575493326 0 0 0.00355779074923997 0.999691143541039 0.99920939533685 0.999915840803364 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Gly385Ser mtrB_p.Gly385Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 935 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Gly392Val mtrB_p.Gly392Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 940 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Gly506Asp mtrB_p.Gly506Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 952 1032 False False 0 0 30.2740898875531 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Gly90Arg mtrB_p.Gly90Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 948 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.His255Asn mtrB_p.His255Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 484.286119137424 1 426 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.His324Arg mtrB_p.His324Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 926 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.His386Pro mtrB_p.His386Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 950 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Ile198Asn mtrB_p.Ile198Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 978 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Ile393Met mtrB_p.Ile393Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 967 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Ile78Val mtrB_p.Ile78Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 936 1032 False False 0 0 30.2740898875531 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Leu26Val mtrB_p.Leu26Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Leu396Val mtrB_p.Leu396Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 484.286119137424 1 426 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Leu47Ile mtrB_p.Leu47Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 937 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Met517Leu mtrB_p.Met517Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 5252 85 5167 979 11557 56 1394 0.945893719806763 0.930310493251274 0.958873315474002 0.107636475947803 0.102348849197384 0.113101131635018 0.0780950861518825 0.0734565211549868 0.0829306321889028 0.0161843107387661 0.0129473769623657 0.0199737473493051 0.00730115100498196 0.00583594337032808 0.00902018205537169 0.40950123033537 0.287284461103412 0.587771302483048 1.2447630598961e-06 20 1032 True False 2.10868799367112 1.59978345561017 2.82823450675948 0.602836879432624 0.517063527721882 0.684195015737458 0.107636475947803 0.102348849197384 0.113101131635018 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 472 64 408 854 1095 47 154 0.947835738068812 0.931233413729631 0.961423329922991 0.123298638911128 0.105567917552476 0.142823354792576 0.438173422267829 0.415996419670172 0.460536734725209 0.135593220338983 0.106013020073525 0.169827278902177 0.0552200172562553 0.0427824175088764 0.0699709211985945 0.513975803087192 0.331368380581224 0.802399317470415 0.00216278906073175 15 299 True False 0 0 0 0 0 0 0 2.55544544836296 1.80731700151153 3.66614624198445 0.576576576576576 0.479157278493809 0.669806302893165 0.123298638911128 0.105567917552476 0.142823354792576 32349 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Met530Ile mtrB_p.Met530Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 966 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 288 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 2 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Phe175Leu mtrB_p.Phe175Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 6 1035 12945 0 0 0.00355779074923997 0.999536715311559 0.998991899081557 0.999829964314549 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 932 1032 False False 0 0 10.6366244843314 0 0 0.00355779074923997 0.999536715311559 0.998991899081557 0.999829964314549 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Phe292Leu mtrB_p.Phe292Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 971 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Pro146Leu mtrB_p.Pro146Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 972 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Pro151Arg mtrB_p.Pro151Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 968 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Pro18Leu mtrB_p.Pro18Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 938 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Pro18Ser mtrB_p.Pro18Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 28 0 28 206 4529 829 8422 0.19903381642512 0.175109455638605 0.224682886444257 0.650297274341749 0.642012606907946 0.658514353966922 0.0435058078141499 0.0378730261256725 0.0497098043723602 0 0 0.123436118500263 0 0 0.000814170360366973 0 0 1.4339471722211 0.17160663870771 166 1032 False False 0.462088974391277 0.393082221821135 0.541337362818903 0 0 0.00443990860911768 0.650297274341749 0.642012606907946 0.658514353966922 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 154 554 747 695 0.170921198668146 0.146894176465072 0.197121454843221 0.556445156124899 0.528387202221559 0.584236813514819 0.217514124293785 0.187648385040942 0.249754873832998 0 0 0.841886116991581 0 0 0.0066365076380498 0 0 4.96684147528246 0.232813678797058 78 299 False False 0 0 0 0 0 0 0 0.258627772220047 0.20901268523179 0.319236385976331 0 0 0.00492608582017336 0.556445156124899 0.528387202221559 0.584236813514819 10724 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Pro200Leu mtrB_p.Pro200Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 941 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Pro529Leu mtrB_p.Pro529Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 929 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Pro536Ser mtrB_p.Pro536Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 947 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Pro548Leu mtrB_p.Pro548Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 944 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Ser16Tyr mtrB_p.Ser16Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 965 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Ser176Ala mtrB_p.Ser176Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 942 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Ser176Phe mtrB_p.Ser176Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 981 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Ser24Arg mtrB_p.Ser24Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 933 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Ser257Pro mtrB_p.Ser257Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 945 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 901 1247 0 0 0.0040858359972341 0.99839871897518 0.994227708034801 0.999806018576913 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 285 299 False False 0 0 0 0 0 0 0 0 0 7.38115169544997 0 0 0.0040858359972341 0.99839871897518 0.994227708034801 0.999806018576913 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Ser283Tyr mtrB_p.Ser283Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 953 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Ser478Phe mtrB_p.Ser478Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 943 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Ser566Arg mtrB_p.Ser566Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 958 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Thr169Ala mtrB_p.Thr169Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 5 1035 12946 0 0 0.00355779074923997 0.999613929426299 0.999099271995683 0.999874632432309 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 976 1032 False False 0 0 13.6669955985752 0 0 0.00355779074923997 0.999613929426299 0.999099271995683 0.999874632432309 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Thr336Ala mtrB_p.Thr336Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Thr66Ile mtrB_p.Thr66Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 973 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 24 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Tyr165Cys mtrB_p.Tyr165Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 969 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Val170Leu mtrB_p.Val170Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 974 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Val237Ala mtrB_p.Val237Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 930 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Val237Leu mtrB_p.Val237Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 979 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Val273Met mtrB_p.Val273Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 927 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Val30Ile mtrB_p.Val30Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 484.286119137424 1 426 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Val377Ile mtrB_p.Val377Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 962 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Val404Ala mtrB_p.Val404Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 16 3) Uncertain significance New Uncertain no 0 +Bedaquiline mtrB p.Val88Ala mtrB_p.Val88Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 980 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline pepQ c.1029A>C pepQ_c.1029A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline pepQ c.105C>A pepQ_c.105C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline pepQ c.1107G>C pepQ_c.1107G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline pepQ c.120C>T pepQ_c.120C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline pepQ c.132G>A pepQ_c.132G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline pepQ c.144T>C pepQ_c.144T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline pepQ c.153T>C pepQ_c.153T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline pepQ c.165C>T pepQ_c.165C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline pepQ c.-17G>T pepQ_c.-17G>T 1 upstream_gene_variant 2860435 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline pepQ c.189G>A pepQ_c.189G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline pepQ c.-18C>T pepQ_c.-18C>T 1 upstream_gene_variant 2860436 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 0 0 0.975 0 0 0.975 0 0 54.0184755945099 1 186 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 13 3) Uncertain significance New Uncertain no 0 +Bedaquiline pepQ c.198G>A pepQ_c.198G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline pepQ c.1G>A pepQ_c.1G>A 1 initiator_codon_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline pepQ c.21A>C pepQ_c.21A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline pepQ c.240G>A pepQ_c.240G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 1034 12949 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999845571770519 0.999442264649511 0.999981297477798 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 6.26160541586073 0.106032338278929 120.386237357489 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf NA NA NA NA NA NA 25 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline pepQ c.261C>G pepQ_c.261C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline pepQ c.318C>T pepQ_c.318C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline pepQ c.339G>A pepQ_c.339G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline pepQ c.372A>G pepQ_c.372A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 1035 12947 0 0 0.00355779074923997 0.999691143541039 0.99920939533685 0.999915840803364 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 18.9615575493326 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 54.0184755945099 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline pepQ c.381T>C pepQ_c.381T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline pepQ c.402T>C pepQ_c.402T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline pepQ c.411C>T pepQ_c.411C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline pepQ c.460C>T pepQ_c.460C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline pepQ c.483C>T pepQ_c.483C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 901 1247 0 0 0.0040858359972341 0.99839871897518 0.994227708034801 0.999806018576913 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 7.38115169544997 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline pepQ c.516G>A pepQ_c.516G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline pepQ c.54G>T pepQ_c.54G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline pepQ c.555T>G pepQ_c.555T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 6 1035 12945 0 0 0.00355779074923997 0.999536715311559 0.998991899081557 0.999829964314549 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 10.6366244843314 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 14 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline pepQ c.558C>T pepQ_c.558C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline pepQ c.585T>C pepQ_c.585T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline pepQ c.-5G>A pepQ_c.-5G>A 1 upstream_gene_variant 2860423 1 1 0 1 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 484.286119137424 1 426 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline pepQ c.693C>T pepQ_c.693C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline pepQ c.72C>T pepQ_c.72C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 1034 12950 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999922785885259 0.999569866411227 0.99999804510978 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 12.5241779497098 0.159396979672639 974.620016429296 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline pepQ c.756G>T pepQ_c.756G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline pepQ c.768G>A pepQ_c.768G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline pepQ c.774G>A pepQ_c.774G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline pepQ c.795G>A pepQ_c.795G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 30.2740898875531 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 12 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline pepQ c.804C>G pepQ_c.804C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 1035 12947 0 0 0.00355779074923997 0.999691143541039 0.99920939533685 0.999915840803364 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 18.9615575493326 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline pepQ c.873T>G pepQ_c.873T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 1035 12946 0 0 0.00355779074923997 0.999613929426299 0.999099271995683 0.999874632432309 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 13.6669955985752 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 901 1247 0 0 0.0040858359972341 0.99839871897518 0.994227708034801 0.999806018576913 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 7.38115169544997 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline pepQ c.876C>T pepQ_c.876C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 1035 12946 0 0 0.00355779074923997 0.999613929426299 0.999099271995683 0.999874632432309 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 13.6669955985752 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline pepQ c.879A>G pepQ_c.879A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline pepQ c.99A>G pepQ_c.99A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline pepQ LoF pepQ_LoF 1 LoF (see "Genomic_coordinates" sheet) 1 11 7 4 8 4 1027 12947 0.00772946859903381 0.00334277076300263 0.0151730581725558 0.999691143541039 0.99920939533685 0.999915840803364 0.666666666666666 0.348875506418814 0.900753908850416 0.636363636363636 0.307904715011677 0.890736556180901 0.636363636363636 0.307904715011677 0.890736556180901 22.0615871470301 5.59460822508888 102.949220801696 2.99976451903463e-06 23 1032 True False 25.2132424537487 6.73648881114847 114.796190294378 0.00676982591876208 0.00272602564678908 0.0138984062186954 0.999691143541039 0.99920939533685 0.999915840803364 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance 1 6 6 0 7 0 894 1249 0.00776914539400666 0.00312913909316045 0.0159415364957336 1 0.997050890854678 1 1 0.590383602774996 1 1 0.540741873560099 1 1 0.540741873560099 1 Inf 1.63950478893088 Inf 0.00534339763294628 17.5 299 False False 0 0 0 0 0 0 0 Inf 2.0065805970492 Inf 0.00666666666666666 0.00245036285732616 0.0144536801734451 1 0.997050890854678 1 NA Marker of R Evidence from ALL dataset only 2) Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV New AwRI yes ALL only C 5 +Bedaquiline pepQ p.Ala124Val pepQ_p.Ala124Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 484.286119137424 1 426 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Bedaquiline pepQ p.Ala137Ser pepQ_p.Ala137Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline pepQ p.Ala141Glu pepQ_p.Ala141Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 671 1032 False False Inf 0.320847254634342 Inf 0 0 0.00356122541865182 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 231 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0 0 0.00409036651757122 1 0.997050890854678 1 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline pepQ p.Ala153Gly pepQ_p.Ala153Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline pepQ p.Ala16Gly pepQ_p.Ala16Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline pepQ p.Ala187Glu pepQ_p.Ala187Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 1035 12947 0 0 0.00355779074923997 0.999691143541039 0.99920939533685 0.999915840803364 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 666 1032 False False 0 0 18.9615575493326 0 0 0.00355779074923997 0.999691143541039 0.99920939533685 0.999915840803364 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline pepQ p.Ala227Asp pepQ_p.Ala227Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline pepQ p.Ala242Thr pepQ_p.Ala242Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 1035 12945 0 0 0.00355779074923997 0.999536715311559 0.998991899081557 0.999829964314549 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 10.6366244843314 1 426 1032 False False 0 0 10.6366244843314 0 0 0.00355779074923997 0.999536715311559 0.998991899081557 0.999829964314549 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 13 3) Uncertain significance No change no 1 +Bedaquiline pepQ p.Ala263Val pepQ_p.Ala263Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline pepQ p.Ala275Ser pepQ_p.Ala275Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline pepQ p.Ala305Val pepQ_p.Ala305Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline pepQ p.Ala370Val pepQ_p.Ala370Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 30.2740898875531 1 426 1032 False False 0 0 30.2740898875531 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline pepQ p.Arg170Trp pepQ_p.Arg170Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline pepQ p.Arg278Gly pepQ_p.Arg278Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 0 0 0.975 0 0 0.975 0 0 54.0184755945099 1 186 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline pepQ p.Arg61Cys pepQ_p.Arg61Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline pepQ p.Arg7Gln pepQ_p.Arg7Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 1 7 1 8 1034 12943 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999382287082078 0.998783224071471 0.999733278885799 0.111111111111111 0.00280913674659921 0.482496514917337 0.125 0.0031597235312519 0.526509670875206 0.111111111111111 0.00280913674659921 0.482496514917337 1.78820116054158 0.039639019443392 13.9384328203135 0.45950850885805 176 1032 False False 1.56467601547388 0.03522848885806 11.6904074232412 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999382287082078 0.998783224071471 0.999733278885799 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 900 1248 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 0.99919935948759 0.995547271980628 0.999979729742686 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.38666666666666 0.0176530068458996 108.845447474822 1 167 299 False False 0 0 0 0 0 0 0 1.38666666666666 0.0176530068458996 108.845447474822 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 0.99919935948759 0.995547271980628 0.999979729742686 39 3) Uncertain significance No change no 1 +Bedaquiline pepQ p.Asn118Asp pepQ_p.Asn118Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline pepQ p.Asp108Asn pepQ_p.Asp108Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 669 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline pepQ p.Asp209Glu pepQ_p.Asp209Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline pepQ p.Asp20Gly pepQ_p.Asp20Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 13 3) Uncertain significance New Uncertain no 0 +Bedaquiline pepQ p.Asp232fs pepQ_p.Asp232fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim New AwRI no 5 +Bedaquiline pepQ p.Asp26Ala pepQ_p.Asp26Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 30.2740898875531 1 426 1032 False False 0 0 30.2740898875531 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline pepQ p.Asp26Gly pepQ_p.Asp26Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 1034 12950 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999922785885259 0.999569866411227 0.99999804510978 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 484.788082433345 1 426 1032 False False 12.5241779497098 0.159396979672639 974.620016429296 0 0 0.00356122541865182 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 230 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0 0 0.00409036651757122 1 0.997050890854678 1 1 3) Uncertain significance No change no 1 +Bedaquiline pepQ p.Asp51fs pepQ_p.Asp51fs 1 frameshift (see "Genomic_coordinates" sheet) 1 3 3 0 3 0 1032 12951 0.00289855072463768 0.000598150191171612 0.00844722324607505 1 0.999715206999795 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 5.17684059997845 Inf 0.000404179051296263 37.5 1032 True False Inf 5.17684059997845 Inf 0.00289855072463768 0.000598150191171612 0.00844722324607505 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 3 0 3 0 898 1249 0.00332963374028856 0.000687177581788976 0.00969950356574711 1 0.997050890854678 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.573338395820229 Inf 0.0734544040745661 38 299 False False 0 0 0 0 0 0 0 Inf 0.573338395820229 Inf 0.00332963374028856 0.000687177581788976 0.00969950356574711 1 0.997050890854678 1 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim New AwRI no 5 +Bedaquiline pepQ p.Gln262Arg pepQ_p.Gln262Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 901 1247 0 0 0.0040858359972341 0.99839871897518 0.994227708034801 0.999806018576913 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.38115169544997 0.512872834309089 156.5 299 False False 0 0 0 0 0 0 0 0 0 7.38115169544997 0 0 0.0040858359972341 0.99839871897518 0.994227708034801 0.999806018576913 2 3) Uncertain significance New Uncertain no 0 +Bedaquiline pepQ p.Gln5Arg pepQ_p.Gln5Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 672 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline pepQ p.Gln5* pepQ_p.Gln5* 1 stop_gained (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 670 1032 False False Inf 0.320847254634342 Inf 0 0 0.00356122541865182 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 229 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0 0 0.00409036651757122 1 0.997050890854678 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim New AwRI no 5 +Bedaquiline pepQ p.Gln63Arg pepQ_p.Gln63Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 0 0 0.975 0 0 0.975 0 0 54.0184755945099 1 186 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline pepQ p.Glu177Asp pepQ_p.Glu177Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline pepQ p.Glu191Val pepQ_p.Glu191Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline pepQ p.Glu339del pepQ_p.Glu339del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline pepQ p.Glu360Asp pepQ_p.Glu360Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline pepQ p.Glu89Asp pepQ_p.Glu89Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline pepQ p.Gly112Asp pepQ_p.Gly112Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline pepQ p.Gly197Arg pepQ_p.Gly197Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 30 0 30 0 30 1035 12921 0 0 0.00355779074923997 0.997683576557794 0.996694799431774 0.998436589882542 0 0 0.115703308222027 0 0 0.115703308222027 0 0 0.115703308222027 0 0 1.63643025515753 0.166249977132774 165 1032 False False 0 0 1.63643025515753 0 0 0.00355779074923997 0.997683576557794 0.996694799431774 0.998436589882542 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 41 3) Uncertain significance No change no 1 +Bedaquiline pepQ p.Gly41Asp pepQ_p.Gly41Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline pepQ p.Gly80Arg pepQ_p.Gly80Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline pepQ p.Gly85Cys pepQ_p.Gly85Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline pepQ p.His100fs pepQ_p.His100fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 1034 12950 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999922785885259 0.999569866411227 0.99999804510978 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 12.5241779497098 0.159396979672639 974.620016429296 0.142533667024192 158.5 1032 False False 12.5241779497098 0.159396979672639 974.620016429296 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim UP from Uncertain to AwRI no 4 +Bedaquiline pepQ p.Ile193Thr pepQ_p.Ile193Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 1035 12945 0 0 0.00355779074923997 0.999536715311559 0.998991899081557 0.999829964314549 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 10.6366244843314 1 426 1032 False False 0 0 10.6366244843314 0 0 0.00355779074923997 0.999536715311559 0.998991899081557 0.999829964314549 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 901 1247 0 0 0.0040858359972341 0.99839871897518 0.994227708034801 0.999806018576913 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.38115169544997 0.512872834309089 156.5 299 False False 0 0 0 0 0 0 0 0 0 7.38115169544997 0 0 0.0040858359972341 0.99839871897518 0.994227708034801 0.999806018576913 2 3) Uncertain significance No change no 1 +Bedaquiline pepQ p.Ile193Val pepQ_p.Ile193Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 0 0 0.975 0 0 0.975 0 0 54.0184755945099 1 186 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline pepQ p.Ile24Thr pepQ_p.Ile24Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline pepQ p.Ile28Arg pepQ_p.Ile28Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline pepQ p.Ile302Val pepQ_p.Ile302Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline pepQ p.Leu107Arg pepQ_p.Leu107Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline pepQ p.Leu179Pro pepQ_p.Leu179Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline pepQ p.Leu317fs pepQ_p.Leu317fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim New AwRI no 5 +Bedaquiline pepQ p.Lys367Asn pepQ_p.Lys367Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline pepQ p.Lys94Asn pepQ_p.Lys94Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline pepQ p.Met180Thr pepQ_p.Met180Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 673 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline pepQ p.Met180Val pepQ_p.Met180Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline pepQ p.Phe46Leu pepQ_p.Phe46Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 17 0 17 0 17 1035 12934 0 0 0.00355779074923997 0.998687360049417 0.997899165449346 0.99923515877878 0 0 0.195064322969093 0 0 0.195064322969093 0 0 0.195064322969093 0 0 3.03338281190619 0.632166467183466 180 1032 False False 0 0 3.03338281190619 0 0 0.00355779074923997 0.998687360049417 0.997899165449346 0.99923515877878 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance No change no 1 +Bedaquiline pepQ p.Pro165Gln pepQ_p.Pro165Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline pepQ p.Pro266Ser pepQ_p.Pro266Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline pepQ p.Pro69Leu pepQ_p.Pro69Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 20 0 20 0 21 1035 12930 0 0 0.00355779074923997 0.998378503590456 0.997522432852902 0.998995996718269 0 0 0.161097615219079 0 0 0.168433470983085 0 0 0.161097615219079 0 0 2.5348251507578 0.395462416579982 175 1032 False False 0 0 2.40325373626413 0 0 0.00355779074923997 0.998378503590456 0.997522432852902 0.998995996718269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 0 0 0.975 0 0 0.975 0 0 54.0184755945099 1 186 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 166 3) Uncertain significance No change no 1 +Bedaquiline pepQ p.Ser130Leu pepQ_p.Ser130Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline pepQ p.Ser200Leu pepQ_p.Ser200Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 1033 12951 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.32115755182578 Inf 0.073936360386128 93 1032 False False Inf 2.35115346086273 Inf 0.000967117988394584 2.4485007765631e-05 0.00537653963257833 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 899 1249 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0355837903294945 Inf 0.418799441600744 84 299 False False 0 0 0 0 0 0 0 Inf 0.260427478737382 Inf 0.00111111111111111 2.81305020903278e-05 0.00617501455708113 1 0.997050890854678 1 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline pepQ p.Ser66Leu pepQ_p.Ser66Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline pepQ p.Ser66Pro pepQ_p.Ser66Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 668 1032 False False Inf 0.320847254634342 Inf 0 0 0.00356122541865182 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 228 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0 0 0.00409036651757122 1 0.997050890854678 1 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline pepQ p.Ser99Arg pepQ_p.Ser99Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 667 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Bedaquiline pepQ p.Thr341Ala pepQ_p.Thr341Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 674 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 3) Uncertain significance No change no 1 +Bedaquiline pepQ p.Thr341fs pepQ_p.Thr341fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim New AwRI no 5 +Bedaquiline pepQ p.Thr354Ala pepQ_p.Thr354Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 14 3) Uncertain significance No change no 1 +Bedaquiline pepQ p.Val101Leu pepQ_p.Val101Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline pepQ p.Val104Leu pepQ_p.Val104Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 30.2740898875531 1 426 1032 False False 0 0 30.2740898875531 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline pepQ p.Val158Met pepQ_p.Val158Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 0 0 0.975 0 0 0.975 0 0 54.0184755945099 1 186 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline pepQ p.Val273fs pepQ_p.Val273fs 1 frameshift (see "Genomic_coordinates" sheet) 1 3 2 1 2 1 1033 12950 0.00193236714975845 0.000234104356582827 0.00696277826632085 0.999922785885259 0.999569866411227 0.99999804510978 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 25.0726040658276 1.30341687247419 1463.2013999217 0.0156060848402737 83 1032 False False 25.0726040658276 1.30341687247419 1463.2013999217 0.00193236714975845 0.000234104356582827 0.00696277826632085 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim UP from Uncertain to AwRI no 4 +Bedaquiline pepQ p.Val298Ile pepQ_p.Val298Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 1035 12947 0 0 0.00355779074923997 0.999691143541039 0.99920939533685 0.999915840803364 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 18.9615575493326 1 426 1032 False False 0 0 18.9615575493326 0 0 0.00355779074923997 0.999691143541039 0.99920939533685 0.999915840803364 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 901 1247 0 0 0.0040858359972341 0.99839871897518 0.994227708034801 0.999806018576913 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.38115169544997 0.512872834309089 156.5 299 False False 0 0 0 0 0 0 0 0 0 7.38115169544997 0 0 0.0040858359972341 0.99839871897518 0.994227708034801 0.999806018576913 8 3) Uncertain significance New Uncertain no 0 +Bedaquiline pepQ p.Val324Met pepQ_p.Val324Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline pepQ p.Val328Phe pepQ_p.Val328Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline pepQ p.Val343Ala pepQ_p.Val343Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline pepQ p.Val45Leu pepQ_p.Val45Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 18 0 18 0 18 1035 12933 0 0 0.00355779074923997 0.998610145934676 0.997804317426606 0.999176082923301 0 0 0.185301968137852 0 0 0.185301968137852 0 0 0.185301968137852 0 0 2.84696647001456 0.639358236744078 181 1032 False False 0 0 2.84696647001456 0 0 0.00355779074923997 0.998610145934676 0.997804317426606 0.999176082923301 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 0 0 0.975 0 0 0.975 0 0 54.0184755945099 1 186 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 6 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 c.108G>T Rv0678_c.108G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv0678 c.111T>C Rv0678_c.111T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 9 1035 12942 0 0 0.00355779074923997 0.999305072967338 0.998681223764717 0.999682187439592 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 6.34492522562988 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 901 1246 0 0 0.0040858359972341 0.99759807846277 0.992996755835892 0.999504391864096 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.35381326044578 NA NA NA NA NA NA 18 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv0678 c.127C>T Rv0678_c.127C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv0678 c.138T>C Rv0678_c.138T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv0678 c.168G>A Rv0678_c.168G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv0678 c.195G>A Rv0678_c.195G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv0678 c.297T>G Rv0678_c.297T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv0678 c.309C>T Rv0678_c.309C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv0678 c.318A>G Rv0678_c.318A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 25 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv0678 c.363G>A Rv0678_c.363G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv0678 c.36C>T Rv0678_c.36C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv0678 c.384C>A Rv0678_c.384C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv0678 c.390G>C Rv0678_c.390G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 1035 12946 0 0 0.00355779074923997 0.999613929426299 0.999099271995683 0.999874632432309 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 13.6669955985752 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 21 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv0678 c.408G>A Rv0678_c.408G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv0678 c.435T>C Rv0678_c.435T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv0678 c.441G>A Rv0678_c.441G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv0678 c.447C>T Rv0678_c.447C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv0678 c.460C>T Rv0678_c.460C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv0678 c.87C>T Rv0678_c.87C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv0678 LoF Rv0678_LoF 1 LoF (see "Genomic_coordinates" sheet) 1 511 406 105 424 134 611 12817 0.409661835748792 0.379512141243803 0.440326774462659 0.989653308624816 0.98775747521674 0.991323960980375 0.759856630824372 0.72219486426846 0.794740800744839 0.794520547945205 0.756850100661306 0.828742855217022 0.751851851851851 0.713175453757433 0.787746257217937 81.1114020731042 64.2145079272109 103.099787966721 0 1 1032 True False 66.3752595451547 53.5754057710705 82.3840920433167 0.3992133726647 0.368951810370735 0.43006008797392 0.989653308624816 0.98775747521674 0.991323960980375 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 398 378 20 395 23 506 1226 0.438401775804661 0.405694516383795 0.471513043626499 0.981585268214571 0.972496354483098 0.988291728185471 0.944976076555024 0.918578466877424 0.964803511528883 0.949748743718593 0.923455617462483 0.969038599720192 0.942643391521197 0.915177338990568 0.963297118098457 45.793280632411 28.7752727436931 76.7755822186793 1.24794473373285e-140 1 299 True False 0 0 0 0 0 0 0 41.6111015638425 26.8711129335487 67.0924954120914 0.427601809954751 0.394711188693792 0.460976522963511 0.981585268214571 0.972496354483098 0.988291728185471 NA Marker of R 1) Assoc w R Can only confer resistance if genetically linked to a functional MmpL5 New AwR yes E 5 +Bedaquiline Rv0678 p.Ala101Glu Rv0678_p.Ala101Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Ala102Asp Rv0678_p.Ala102Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Ala102Thr Rv0678_p.Ala102Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 1033 12951 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 2.35115346086273 Inf 0.00547148098095541 62.5 1032 False False Inf 2.35115346086273 Inf 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 899 1249 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.260427478737382 Inf 0.175506184596404 63 299 False False 0 0 0 0 0 0 0 Inf 0.260427478737382 Inf 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 1 3) Uncertain significance New Uncertain AwRI by relaxed thresholds (not endorsed) yes O 0 +Bedaquiline Rv0678 p.Ala110fs Rv0678_p.Ala110fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 1033 12951 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 2.35115346086273 Inf 0.00547148098095541 62.5 1032 False False Inf 2.35115346086273 Inf 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 UP from Uncertain to AwRI AwRI by relaxed thresholds (not endorsed) no E, O 4 +Bedaquiline Rv0678 p.Ala110Val Rv0678_p.Ala110Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Ala112Pro Rv0678_p.Ala112Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Ala112Ser Rv0678_p.Ala112Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Ala144fs Rv0678_p.Ala144fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Bedaquiline Rv0678 p.Ala36Val Rv0678_p.Ala36Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 6 0 6 0 1029 12951 0.00579710144927536 0.00213031671594251 0.0125748589863842 1 0.999715206999795 1 1 0.540741873560099 1 1 0.540741873560099 1 1 0.540741873560099 1 Inf 14.787301377487 Inf 1.62047186938944e-07 15.5 1032 True False Inf 14.787301377487 Inf 0.00579710144927536 0.00213031671594251 0.0125748589863842 1 0.999715206999795 1 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance 1 4 4 0 4 0 897 1249 0.00443951165371809 0.00121090206228936 0.0113275932937957 1 0.997050890854678 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 0.916560415731825 Inf 0.0307228946711506 27 299 False False 0 0 0 0 0 0 0 Inf 0.916560415731825 Inf 0.00443951165371809 0.00121090206228936 0.0113275932937957 1 0.997050890854678 1 NA Evidence from ALL dataset only 2) Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV. Can only confer resistance if genetically linked to a functional MmpL5 UP from Uncertain to AwRI AwRI by relaxed thresholds (not endorsed) yes ALL only C, E, O 4 +Bedaquiline Rv0678 p.Ala59Val Rv0678_p.Ala59Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Ala62fs Rv0678_p.Ala62fs 1 frameshift (see "Genomic_coordinates" sheet) 1 3 1 2 1 2 1034 12949 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999845571770519 0.999442264649511 0.999981297477798 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 6.26160541586073 0.106032338278929 120.386237357489 0.205997458116152 170 1032 False False 6.26160541586073 0.106032338278929 120.386237357489 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 1 2 900 1247 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 0.99839871897518 0.994227708034801 0.999806018576913 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.692777777777777 0.0117351849678213 13.3292134004368 1 186 299 False False 0 0 0 0 0 0 0 0.692777777777777 0.0117351849678213 13.3292134004368 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 0.99839871897518 0.994227708034801 0.999806018576913 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Bedaquiline Rv0678 p.Ala62Thr Rv0678_p.Ala62Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Ala84Val Rv0678_p.Ala84Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 1034 12950 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999922785885259 0.999569866411227 0.99999804510978 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 12.5241779497098 0.159396979672639 974.620016429296 0.142533667024192 158.5 1032 False False 12.5241779497098 0.159396979672639 974.620016429296 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Ala86Val Rv0678_p.Ala86Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Ala99Pro Rv0678_p.Ala99Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 1033 12951 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 2.35115346086273 Inf 0.00547148098095541 62.5 1032 False False Inf 2.35115346086273 Inf 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 NA 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Bedaquiline Rv0678 p.Arg105Ser Rv0678_p.Arg105Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Arg107Cys Rv0678_p.Arg107Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 2 1 2 1 1033 12950 0.00193236714975845 0.000234104356582827 0.00696277826632085 0.999922785885259 0.999569866411227 0.99999804510978 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 25.0726040658276 1.30341687247419 1463.2013999217 0.0156060848402737 83 1032 False False 25.0726040658276 1.30341687247419 1463.2013999217 0.00193236714975845 0.000234104356582827 0.00696277826632085 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 899 1249 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.260427478737382 Inf 0.175506184596404 63 299 False False 0 0 0 0 0 0 0 Inf 0.260427478737382 Inf 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 NA 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Bedaquiline Rv0678 p.Arg107Leu Rv0678_p.Arg107Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Arg109fs Rv0678_p.Arg109fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Bedaquiline Rv0678 p.Arg109Leu Rv0678_p.Arg109Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Arg109Pro Rv0678_p.Arg109Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 1033 12951 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 2.35115346086273 Inf 0.00547148098095541 62.5 1032 False False Inf 2.35115346086273 Inf 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 NA 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Bedaquiline Rv0678 p.Arg109Trp Rv0678_p.Arg109Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Arg123fs Rv0678_p.Arg123fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Bedaquiline Rv0678 p.Arg132fs Rv0678_p.Arg132fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 612 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Bedaquiline Rv0678 p.Arg132* Rv0678_p.Arg132* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Bedaquiline Rv0678 p.Arg134Gly Rv0678_p.Arg134Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 1035 12946 0 0 0.00355779074923997 0.999613929426299 0.999099271995683 0.999874632432309 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 13.6669955985752 1 426 1032 False False 0 0 13.6669955985752 0 0 0.00355779074923997 0.999613929426299 0.999099271995683 0.999874632432309 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Arg134* Rv0678_p.Arg134* 1 stop_gained (see "Genomic_coordinates" sheet) 1 6 6 0 6 0 1029 12951 0.00579710144927536 0.00213031671594251 0.0125748589863842 1 0.999715206999795 1 1 0.540741873560099 1 1 0.540741873560099 1 1 0.540741873560099 1 Inf 14.787301377487 Inf 1.62047186938944e-07 15.5 1032 True False Inf 14.787301377487 Inf 0.00579710144927536 0.00213031671594251 0.0125748589863842 1 0.999715206999795 1 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance 1 6 6 0 6 0 895 1249 0.00665926748057713 0.00244763901399365 0.0144377013063993 1 0.997050890854678 1 1 0.540741873560099 1 1 0.540741873560099 1 1 0.540741873560099 1 Inf 1.63768017916319 Inf 0.00536420751828409 19 299 False False 0 0 0 0 0 0 0 Inf 1.63768017916319 Inf 0.00665926748057713 0.00244763901399365 0.0144377013063993 1 0.997050890854678 1 NA Evidence from ALL dataset only 2) Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV. Can only confer resistance if genetically linked to a functional MmpL5 New AwRI AwRI by relaxed thresholds (not endorsed) no ALL only C, E, O 5 +Bedaquiline Rv0678 p.Arg135Trp Rv0678_p.Arg135Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 3 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Arg156fs Rv0678_p.Arg156fs 1 frameshift (see "Genomic_coordinates" sheet) 1 7 5 2 5 2 1030 12949 0.00483091787439613 0.00157039035246783 0.0112374718131471 0.999845571770519 0.999442264649511 0.999981297477798 0.714285714285714 0.290420863737342 0.963307433823914 0.714285714285714 0.290420863737342 0.963307433823914 0.714285714285714 0.290420863737342 0.963307433823914 31.4296116504854 5.13376724100354 329.132315651006 4.06987330434474e-05 30 1032 True False 31.4296116504854 5.13376724100354 329.132315651006 0.00483091787439613 0.00157039035246783 0.0112374718131471 0.999845571770519 0.999442264649511 0.999981297477798 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance 1 5 5 0 5 0 896 1249 0.00554938956714761 0.0018042535136792 0.0129025590758184 1 0.997050890854678 1 1 0.478176249895018 1 1 0.478176249895018 1 1 0.478176249895018 1 Inf 1.27344498734659 Inf 0.0128417691146421 23 299 False False 0 0 0 0 0 0 0 Inf 1.27344498734659 Inf 0.00554938956714761 0.0018042535136792 0.0129025590758184 1 0.997050890854678 1 2 Evidence from ALL dataset only 2) Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV. Can only confer resistance if genetically linked to a functional MmpL5 UP from Uncertain to AwRI AwRI by relaxed thresholds (not endorsed) no ALL only C, E, O 4 +Bedaquiline Rv0678 p.Arg156Gln Rv0678_p.Arg156Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Arg156* Rv0678_p.Arg156* 1 stop_gained (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 1033 12951 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 2.35115346086273 Inf 0.00547148098095541 62.5 1032 False False Inf 2.35115346086273 Inf 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 899 1249 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.260427478737382 Inf 0.175506184596404 63 299 False False 0 0 0 0 0 0 0 Inf 0.260427478737382 Inf 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI AwRI by relaxed thresholds (not endorsed) no E, O 5 +Bedaquiline Rv0678 p.Arg30fs Rv0678_p.Arg30fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Bedaquiline Rv0678 p.Arg30Trp Rv0678_p.Arg30Trp 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 212 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0 0 0.00409036651757122 1 0.997050890854678 1 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Arg34Gln Rv0678_p.Arg34Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 1033 12951 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 2.35115346086273 Inf 0.00547148098095541 62.5 1032 False False Inf 2.35115346086273 Inf 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 899 1249 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.260427478737382 Inf 0.175506184596404 63 299 False False 0 0 0 0 0 0 0 Inf 0.260427478737382 Inf 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 NA 3) Uncertain significance New Uncertain AwRI by relaxed thresholds (not endorsed) yes O 0 +Bedaquiline Rv0678 p.Arg34Trp Rv0678_p.Arg34Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 1033 12951 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 2.35115346086273 Inf 0.00547148098095541 62.5 1032 False False Inf 2.35115346086273 Inf 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 899 1249 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.260427478737382 Inf 0.175506184596404 63 299 False False 0 0 0 0 0 0 0 Inf 0.260427478737382 Inf 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 1 3) Uncertain significance New Uncertain AwRI by relaxed thresholds (not endorsed) yes O 0 +Bedaquiline Rv0678 p.Arg38Leu Rv0678_p.Arg38Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Arg38* Rv0678_p.Arg38* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 UP from Uncertain to AwRI no E 4 +Bedaquiline Rv0678 p.Arg50dup Rv0678_p.Arg50dup 1 inframe_insertion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 0 0 0.975 0 0 0.975 0 0 54.0184755945099 1 186 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 NA 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Arg50Gln Rv0678_p.Arg50Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 2 1 2 1 1033 12950 0.00193236714975845 0.000234104356582827 0.00696277826632085 0.999922785885259 0.999569866411227 0.99999804510978 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 25.0726040658276 1.30341687247419 1463.2013999217 0.0156060848402737 83 1032 False False 25.0726040658276 1.30341687247419 1463.2013999217 0.00193236714975845 0.000234104356582827 0.00696277826632085 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 4 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Bedaquiline Rv0678 p.Arg50Pro Rv0678_p.Arg50Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Arg50Trp Rv0678_p.Arg50Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Arg72fs Rv0678_p.Arg72fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 UP from Uncertain to AwRI no E 4 +Bedaquiline Rv0678 p.Arg72Trp Rv0678_p.Arg72Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 1034 12950 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999922785885259 0.999569866411227 0.99999804510978 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 12.5241779497098 0.159396979672639 974.620016429296 0.142533667024192 158.5 1032 False False 12.5241779497098 0.159396979672639 974.620016429296 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Arg89fs Rv0678_p.Arg89fs 1 frameshift (see "Genomic_coordinates" sheet) 1 3 3 0 3 0 1032 12951 0.00289855072463768 0.000598150191171612 0.00844722324607505 1 0.999715206999795 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 5.17684059997845 Inf 0.000404179051296263 37.5 1032 True False Inf 5.17684059997845 Inf 0.00289855072463768 0.000598150191171612 0.00844722324607505 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 3 0 3 0 898 1249 0.00332963374028856 0.000687177581788976 0.00969950356574711 1 0.997050890854678 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.573338395820229 Inf 0.0734544040745661 38 299 False False 0 0 0 0 0 0 0 Inf 0.573338395820229 Inf 0.00332963374028856 0.000687177581788976 0.00969950356574711 1 0.997050890854678 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI AwRI by relaxed thresholds (not endorsed) no E, O 5 +Bedaquiline Rv0678 p.Arg89Gln Rv0678_p.Arg89Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 2 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Arg89Leu Rv0678_p.Arg89Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Arg89Trp Rv0678_p.Arg89Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 901 1247 0 0 0.0040858359972341 0.99839871897518 0.994227708034801 0.999806018576913 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.38115169544997 0.512872834309089 156.5 299 False False 0 0 0 0 0 0 0 0 0 7.38115169544997 0 0 0.0040858359972341 0.99839871897518 0.994227708034801 0.999806018576913 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Arg90Cys Rv0678_p.Arg90Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 2 7 2 8 1033 12943 0.00193236714975845 0.000234104356582827 0.00696277826632085 0.999382287082078 0.998783224071471 0.999733278885799 0.2 0.0252107263268333 0.556095462307641 0.222222222222222 0.0281449734778982 0.600093573716312 0.2 0.0252107263268333 0.556095462307641 3.57986447241045 0.362357313124467 18.8256499190888 0.139320375019935 152 1032 False False 3.13238141335914 0.323601276440422 15.7291739405934 0.00193236714975845 0.000234104356582827 0.00696277826632085 0.999382287082078 0.998783224071471 0.999733278885799 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 900 1248 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 0.99919935948759 0.995547271980628 0.999979729742686 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.38666666666666 0.0176530068458996 108.845447474822 1 167 299 False False 0 0 0 0 0 0 0 1.38666666666666 0.0176530068458996 108.845447474822 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 0.99919935948759 0.995547271980628 0.999979729742686 2 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Arg94Gln Rv0678_p.Arg94Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Arg94Trp Rv0678_p.Arg94Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 3 1 3 1 1032 12950 0.00289855072463768 0.000598150191171612 0.00844722324607505 0.999922785885259 0.999569866411227 0.99999804510978 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 37.6453488372093 3.01751469574157 1949.96293381012 0.00152722622858395 44.5 1032 True False 37.6453488372093 3.01751469574157 1949.96293381012 0.00289855072463768 0.000598150191171612 0.00844722324607505 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 3 0 3 0 898 1249 0.00332963374028856 0.000687177581788976 0.00969950356574711 1 0.997050890854678 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.573338395820229 Inf 0.0734544040745661 38 299 False False 0 0 0 0 0 0 0 Inf 0.573338395820229 Inf 0.00332963374028856 0.000687177581788976 0.00969950356574711 1 0.997050890854678 1 NA 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Bedaquiline Rv0678 p.Arg96Gly Rv0678_p.Arg96Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Arg96Leu Rv0678_p.Arg96Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 1034 12950 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999922785885259 0.999569866411227 0.99999804510978 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 12.5241779497098 0.159396979672639 974.620016429296 0.142533667024192 158.5 1032 False False 12.5241779497098 0.159396979672639 974.620016429296 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 NA 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Arg96Trp Rv0678_p.Arg96Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 1034 12950 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999922785885259 0.999569866411227 0.99999804510978 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 12.5241779497098 0.159396979672639 974.620016429296 0.142533667024192 158.5 1032 False False 12.5241779497098 0.159396979672639 974.620016429296 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 2 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Asn148fs Rv0678_p.Asn148fs 1 frameshift (see "Genomic_coordinates" sheet) 1 3 3 0 3 0 1032 12951 0.00289855072463768 0.000598150191171612 0.00844722324607505 1 0.999715206999795 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 5.17684059997845 Inf 0.000404179051296263 37.5 1032 True False Inf 5.17684059997845 Inf 0.00289855072463768 0.000598150191171612 0.00844722324607505 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 3 0 3 0 898 1249 0.00332963374028856 0.000687177581788976 0.00969950356574711 1 0.997050890854678 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.573338395820229 Inf 0.0734544040745661 38 299 False False 0 0 0 0 0 0 0 Inf 0.573338395820229 Inf 0.00332963374028856 0.000687177581788976 0.00969950356574711 1 0.997050890854678 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI AwRI by relaxed thresholds (not endorsed) no E, O 5 +Bedaquiline Rv0678 p.Asn4Thr Rv0678_p.Asn4Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 4 7 1031 12944 0.0038647342995169 0.00105398325986622 0.009865452176262 0.999459501196818 0.998886684999561 0.999782664716124 0.363636363636363 0.109263443819098 0.692095284988322 0 0 0.409616397225003 0 0 0.409616397225003 0 0 8.72338044907609 1 426 1032 False False 7.17417209366772 1.53708186769877 28.275247873635 0 0 0.00357156933212359 0.999459501196818 0.998886684999561 0.999782664716124 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 4 2 897 1247 0.00443951165371809 0.00121090206228936 0.0113275932937957 0.99839871897518 0.994227708034801 0.999806018576913 0.666666666666666 0.222778095503512 0.956728131707258 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.41408192777835 0.513225451156485 162 299 False False 0 0 0 0 0 0 0 2.7803790412486 0.397314242958189 30.7799921643675 0 0 0.0041040185629249 0.99839871897518 0.994227708034801 0.999806018576913 14 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Asn70Asp Rv0678_p.Asn70Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 6 1 6 1 1029 12950 0.00579710144927536 0.00213031671594251 0.0125748589863842 0.999922785885259 0.999569866411227 0.99999804510978 0.857142857142857 0.421276802956804 0.996389703138099 0.857142857142857 0.421276802956804 0.996389703138099 0.857142857142857 0.421276802956804 0.996389703138099 75.5102040816326 9.14025130621506 3397.43189759436 1.06276526335365e-06 19 1032 True False 75.5102040816326 9.14025130621506 3397.43189759436 0.00579710144927536 0.00213031671594251 0.0125748589863842 0.999922785885259 0.999569866411227 0.99999804510978 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance 1 5 5 0 5 0 896 1249 0.00554938956714761 0.0018042535136792 0.0129025590758184 1 0.997050890854678 1 1 0.478176249895018 1 1 0.478176249895018 1 1 0.478176249895018 1 Inf 1.27344498734659 Inf 0.0128417691146421 23 299 False False 0 0 0 0 0 0 0 Inf 1.27344498734659 Inf 0.00554938956714761 0.0018042535136792 0.0129025590758184 1 0.997050890854678 1 NA Evidence from ALL dataset only 2) Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV. Can only confer resistance if genetically linked to a functional MmpL5 UP from Uncertain to AwRI AwRI by relaxed thresholds (not endorsed) yes ALL only C, E, O 4 +Bedaquiline Rv0678 p.Asn70fs Rv0678_p.Asn70fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Bedaquiline Rv0678 p.Asn70Ile Rv0678_p.Asn70Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 1033 12951 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 2.35115346086273 Inf 0.00547148098095541 62.5 1032 False False Inf 2.35115346086273 Inf 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 899 1249 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.260427478737382 Inf 0.175506184596404 63 299 False False 0 0 0 0 0 0 0 Inf 0.260427478737382 Inf 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 NA 3) Uncertain significance New Uncertain AwRI by relaxed thresholds (not endorsed) yes O 0 +Bedaquiline Rv0678 p.Asn70Lys Rv0678_p.Asn70Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 2 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Asn98Asp Rv0678_p.Asn98Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 1 8 1 8 1034 12943 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999382287082078 0.998783224071471 0.999733278885799 0.111111111111111 0.00280913674659921 0.482496514917337 0.111111111111111 0.00280913674659921 0.482496514917337 0.111111111111111 0.00280913674659921 0.482496514917337 1.56467601547388 0.03522848885806 11.6904074232412 0.499506270429044 177 1032 False False 1.56467601547388 0.03522848885806 11.6904074232412 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999382287082078 0.998783224071471 0.999733278885799 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 6 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Asn98fs Rv0678_p.Asn98fs 1 frameshift (see "Genomic_coordinates" sheet) 1 16 13 3 13 3 1022 12948 0.0125603864734299 0.00670436442016884 0.0213828722645358 0.999768357655779 0.999323193486146 0.999952227231941 0.8125 0.543543453768388 0.959526266094054 0.8125 0.543543453768388 0.959526266094054 0.8125 0.543543453768388 0.959526266094054 54.9001956947162 15.0447328976546 298.375044289311 8.44016630521001e-13 8 1032 True False 54.9001956947162 15.0447328976546 298.375044289311 0.0125603864734299 0.00670436442016884 0.0213828722645358 0.999768357655779 0.999323193486146 0.999952227231941 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 11 11 0 11 0 890 1249 0.0122086570477247 0.00610984137345395 0.02173945292066 1 0.997050890854678 1 1 0.715085847081845 1 1 0.715085847081845 1 1 0.715085847081845 1 Inf 3.50864469425713 Inf 6.75558997755072e-05 8 299 True False 0 0 0 0 0 0 0 Inf 3.50864469425713 Inf 0.0122086570477247 0.00610984137345395 0.02173945292066 1 0.997050890854678 1 4 Potentially inflated PPV 2) Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV. Can only confer resistance if genetically linked to a functional MmpL5 New AwRI AwRI by relaxed thresholds (not endorsed) no Pot. Infl. PPV C, E, O 5 +Bedaquiline Rv0678 p.Asp116fs Rv0678_p.Asp116fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Bedaquiline Rv0678 p.Asp141fs Rv0678_p.Asp141fs 1 frameshift (see "Genomic_coordinates" sheet) 1 6 2 4 2 6 1033 12945 0.00193236714975845 0.000234104356582827 0.00696277826632085 0.999536715311559 0.998991899081557 0.999829964314549 0.25 0.0318540262499442 0.650855794412824 0.333333333333333 0.0432718682927417 0.777221904496487 0.25 0.0318540262499442 0.650855794412824 6.26573088092933 0.566007686059446 43.8009584263768 0.067212693757009 91 1032 False False 4.17715392061955 0.411745296199796 23.3861334261666 0.00193236714975845 0.000234104356582827 0.00696277826632085 0.999536715311559 0.998991899081557 0.999829964314549 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 899 1249 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.260427478737382 Inf 0.175506184596404 63 299 False False 0 0 0 0 0 0 0 Inf 0.260427478737382 Inf 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 7 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 UP from Uncertain to AwRI AwRI by relaxed thresholds (not endorsed) no E, O 4 +Bedaquiline Rv0678 p.Asp141Tyr Rv0678_p.Asp141Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Asp165fs Rv0678_p.Asp165fs 1 frameshift (see "Genomic_coordinates" sheet) 1 5 4 1 4 1 1031 12950 0.0038647342995169 0.00105398325986622 0.009865452176262 0.999922785885259 0.999569866411227 0.99999804510978 0.8 0.28358206388191 0.994949236620532 0.8 0.28358206388191 0.994949236620532 0.8 0.28358206388191 0.994949236620532 50.2424830261881 4.96193488528776 2434.71250319886 0.000140351585387884 32 1032 True False 50.2424830261881 4.96193488528776 2434.71250319886 0.0038647342995169 0.00105398325986622 0.009865452176262 0.999922785885259 0.999569866411227 0.99999804510978 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance 1 4 4 0 4 0 897 1249 0.00443951165371809 0.00121090206228936 0.0113275932937957 1 0.997050890854678 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 0.916560415731825 Inf 0.0307228946711506 27 299 False False 0 0 0 0 0 0 0 Inf 0.916560415731825 Inf 0.00443951165371809 0.00121090206228936 0.0113275932937957 1 0.997050890854678 1 NA Evidence from ALL dataset only 2) Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV. Can only confer resistance if genetically linked to a functional MmpL5 UP from Uncertain to AwRI AwRI by relaxed thresholds (not endorsed) no ALL only C, E, O 4 +Bedaquiline Rv0678 p.Asp47dup Rv0678_p.Asp47dup 1 inframe_insertion (see "Genomic_coordinates" sheet) 1 3 3 0 3 0 1032 12951 0.00289855072463768 0.000598150191171612 0.00844722324607505 1 0.999715206999795 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 5.17684059997845 Inf 0.000404179051296263 37.5 1032 True False Inf 5.17684059997845 Inf 0.00289855072463768 0.000598150191171612 0.00844722324607505 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 3 0 3 0 898 1249 0.00332963374028856 0.000687177581788976 0.00969950356574711 1 0.997050890854678 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.573338395820229 Inf 0.0734544040745661 38 299 False False 0 0 0 0 0 0 0 Inf 0.573338395820229 Inf 0.00332963374028856 0.000687177581788976 0.00969950356574711 1 0.997050890854678 1 NA 3) Uncertain significance New Uncertain AwRI by relaxed thresholds (not endorsed) yes O 0 +Bedaquiline Rv0678 p.Asp47fs Rv0678_p.Asp47fs 1 frameshift (see "Genomic_coordinates" sheet) 1 83 59 24 61 25 974 12926 0.0589371980676328 0.0453786599380392 0.0750668530975943 0.998069647131495 0.997151728273788 0.998750399924747 0.709302325581395 0.601440145694699 0.802246134677814 0.710843373493975 0.600947492603723 0.805156931858937 0.702380952380952 0.592723646087301 0.797270818207111 32.6246577686516 19.8679110253322 54.9861062554001 3.0166720908077e-48 3 1032 True False 32.3813552361396 19.9079694183062 54.0240654559656 0.0571151984511132 0.0437595227975942 0.0730592759644365 0.998069647131495 0.997151728273788 0.998750399924747 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 64 56 8 58 8 843 1241 0.0643729189789123 0.0492403487719326 0.0824253820030266 0.99359487590072 0.98741855030806 0.99723078615598 0.878787878787878 0.775059844276842 0.946189138158134 0.875 0.768473694033996 0.944457208820398 0.875 0.768473694033996 0.944457208820398 10.3048635824436 4.84880372731063 25.1584749261585 1.87847729902087e-14 4 299 True False 0 0 0 0 0 0 0 10.6728944246737 5.0337044811394 25.993127245959 0.0622914349276974 0.0473937407828794 0.0801315313053324 0.99359487590072 0.98741855030806 0.99723078615598 14 1) Assoc w R Can only confer resistance if genetically linked to a functional MmpL5 New AwR yes E 5 +Bedaquiline Rv0678 p.Asp47Glu Rv0678_p.Asp47Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 0 1031 12951 0.0038647342995169 0.00105398325986622 0.009865452176262 1 0.999715206999795 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 609 1032 False False Inf 8.27463359653372 Inf 0 0 0.00357156933212359 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 0 897 1249 0.00443951165371809 0.00121090206228936 0.0113275932937957 1 0.997050890854678 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 211 299 False False 0 0 0 0 0 0 0 Inf 0.916560415731825 Inf 0 0 0.0041040185629249 1 0.997050890854678 1 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Asp47Gly Rv0678_p.Asp47Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Asp5Asn Rv0678_p.Asp5Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Asp5Gly Rv0678_p.Asp5Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 24 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Asp8fs Rv0678_p.Asp8fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Bedaquiline Rv0678 p.Asp8Gly Rv0678_p.Asp8Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Cys46_Asp47insGly Rv0678_p.Cys46_Asp47insGly 1 inframe_insertion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Cys46Arg Rv0678_p.Cys46Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 10 9 1 9 1 1026 12950 0.00869565217391304 0.003983694112966 0.0164426238532791 0.999922785885259 0.999569866411227 0.99999804510978 0.9 0.554983882971804 0.997471421455538 0.9 0.554983882971804 0.997471421455538 0.9 0.554983882971804 0.997471421455538 113.59649122807 15.704412722481 4822.42117436137 6.01877976530644e-10 11.5 1032 True False 113.59649122807 15.704412722481 4822.42117436137 0.00869565217391304 0.003983694112966 0.0164426238532791 0.999922785885259 0.999569866411227 0.99999804510978 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 9 9 0 9 0 892 1249 0.0099889012208657 0.0045774481074401 0.0188770305115852 1 0.997050890854678 1 1 0.663732883120057 1 1 0.663732883120057 1 1 0.663732883120057 1 Inf 2.75364434161667 Inf 0.000389449512863354 11 299 True False 0 0 0 0 0 0 0 Inf 2.75364434161667 Inf 0.0099889012208657 0.0045774481074401 0.0188770305115852 1 0.997050890854678 1 2 Potentially inflated PPV 2) Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV. Can only confer resistance if genetically linked to a functional MmpL5 UP from Uncertain to AwRI AwRI by relaxed thresholds (not endorsed) yes Pot. Infl. PPV C, E, O 4 +Bedaquiline Rv0678 p.Cys46fs Rv0678_p.Cys46fs 1 frameshift (see "Genomic_coordinates" sheet) 1 9 7 2 11 2 1024 12949 0.0106280193236714 0.00531707433425849 0.0189367299858332 0.999845571770519 0.999442264649511 0.999981297477798 0.846153846153846 0.545528944323442 0.980793328017471 0.777777777777777 0.399906426283687 0.971855026522101 0.777777777777777 0.399906426283687 0.971855026522101 44.25927734375 8.4066938888822 436.586840006413 3.66768281956058e-07 18 1032 True False 69.55029296875 15.1380867204522 643.754272997829 0.00678952473326867 0.00273397013041824 0.0139387018950419 0.999845571770519 0.999442264649511 0.999981297477798 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 7 7 0 11 0 890 1249 0.0122086570477247 0.00610984137345395 0.02173945292066 1 0.997050890854678 1 1 0.715085847081845 1 1 0.590383602774996 1 1 0.590383602774996 1 Inf 2.01561923333966 Inf 0.0021988780841977 16 299 True False 0 0 0 0 0 0 0 Inf 3.50864469425713 Inf 0.00780379041248606 0.00314311778402297 0.0160123299630607 1 0.997050890854678 1 NA Potentially inflated PPV 2) Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV. Can only confer resistance if genetically linked to a functional MmpL5 New AwRI AwRI by relaxed thresholds (not endorsed) no Pot. Infl. PPV C, E, O 5 +Bedaquiline Rv0678 p.Cys46Gly Rv0678_p.Cys46Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Cys46Trp Rv0678_p.Cys46Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 1033 12951 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 2.35115346086273 Inf 0.00547148098095541 62.5 1032 False False Inf 2.35115346086273 Inf 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 899 1249 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.260427478737382 Inf 0.175506184596404 63 299 False False 0 0 0 0 0 0 0 Inf 0.260427478737382 Inf 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 NA 3) Uncertain significance New Uncertain AwRI by relaxed thresholds (not endorsed) yes O 0 +Bedaquiline Rv0678 p.Cys46Tyr Rv0678_p.Cys46Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Gln115Pro Rv0678_p.Gln115Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 1033 12951 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 2.35115346086273 Inf 0.00547148098095541 62.5 1032 False False Inf 2.35115346086273 Inf 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 899 1249 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.260427478737382 Inf 0.175506184596404 63 299 False False 0 0 0 0 0 0 0 Inf 0.260427478737382 Inf 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 NA 3) Uncertain significance New Uncertain AwRI by relaxed thresholds (not endorsed) yes O 0 +Bedaquiline Rv0678 p.Gln115* Rv0678_p.Gln115* 1 stop_gained (see "Genomic_coordinates" sheet) 1 5 3 2 3 2 1032 12949 0.00289855072463768 0.000598150191171612 0.00844722324607505 0.999845571770519 0.999442264649511 0.999981297477798 0.6 0.146632799634673 0.947255049473683 0.6 0.146632799634673 0.947255049473683 0.6 0.146632799634673 0.947255049473683 18.8212209302325 2.15233396249282 224.885364370249 0.00360753819337804 47 1032 False False 18.8212209302325 2.15233396249282 224.885364370249 0.00289855072463768 0.000598150191171612 0.00844722324607505 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 3 0 3 0 898 1249 0.00332963374028856 0.000687177581788976 0.00969950356574711 1 0.997050890854678 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.573338395820229 Inf 0.0734544040745661 38 299 False False 0 0 0 0 0 0 0 Inf 0.573338395820229 Inf 0.00332963374028856 0.000687177581788976 0.00969950356574711 1 0.997050890854678 1 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 UP from Uncertain to AwRI AwRI by relaxed thresholds (not endorsed) no E, O 4 +Bedaquiline Rv0678 p.Gln159fs Rv0678_p.Gln159fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 1033 12951 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 2.35115346086273 Inf 0.00547148098095541 62.5 1032 False False Inf 2.35115346086273 Inf 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 899 1249 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.260427478737382 Inf 0.175506184596404 63 299 False False 0 0 0 0 0 0 0 Inf 0.260427478737382 Inf 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI AwRI by relaxed thresholds (not endorsed) no E, O 5 +Bedaquiline Rv0678 p.Gln22Arg Rv0678_p.Gln22Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Gln22Pro Rv0678_p.Gln22Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Gln22* Rv0678_p.Gln22* 1 stop_gained (see "Genomic_coordinates" sheet) 1 4 3 1 3 1 1032 12950 0.00289855072463768 0.000598150191171612 0.00844722324607505 0.999922785885259 0.999569866411227 0.99999804510978 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 37.6453488372093 3.01751469574157 1949.96293381012 0.00152722622858395 44.5 1032 True False 37.6453488372093 3.01751469574157 1949.96293381012 0.00289855072463768 0.000598150191171612 0.00844722324607505 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 3 1 3 1 898 1248 0.00332963374028856 0.000687177581788976 0.00969950356574711 0.99919935948759 0.995547271980628 0.999979729742686 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 4.16926503340757 0.333935063681581 218.791095337293 0.315312248468687 82 299 False False 0 0 0 0 0 0 0 4.16926503340757 0.333935063681581 218.791095337293 0.00332963374028856 0.000687177581788976 0.00969950356574711 0.99919935948759 0.995547271980628 0.999979729742686 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI AwRI by relaxed thresholds (not endorsed) no E, O 5 +Bedaquiline Rv0678 p.Gln51Arg Rv0678_p.Gln51Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 1 2 1034 12949 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999845571770519 0.999442264649511 0.999981297477798 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 6.26160541586073 0.106032338278929 120.386237357489 0.205997458116152 170 1032 False False 6.26160541586073 0.106032338278929 120.386237357489 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Gln51fs Rv0678_p.Gln51fs 1 frameshift (see "Genomic_coordinates" sheet) 1 10 10 0 10 0 1025 12951 0.00966183574879227 0.00464267349503022 0.0176964729633415 1 0.999715206999795 1 1 0.691502892181239 1 1 0.691502892181239 1 1 0.691502892181239 1 Inf 28.2421806464377 Inf 4.73070113930594e-12 9 1032 True False Inf 28.2421806464377 Inf 0.00966183574879227 0.00464267349503022 0.0176964729633415 1 0.999715206999795 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 10 10 0 10 0 891 1249 0.0110987791342952 0.00533477009732139 0.0203160650401229 1 0.997050890854678 1 1 0.691502892181239 1 1 0.691502892181239 1 1 0.691502892181239 1 Inf 3.13005215401415 Inf 0.00016225547196362 10 299 True False 0 0 0 0 0 0 0 Inf 3.13005215401415 Inf 0.0110987791342952 0.00533477009732139 0.0203160650401229 1 0.997050890854678 1 NA Potentially inflated PPV 2) Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV. Can only confer resistance if genetically linked to a functional MmpL5 New AwRI AwRI by relaxed thresholds (not endorsed) no Pot. Infl. PPV C, E, O 5 +Bedaquiline Rv0678 p.Gln51Lys Rv0678_p.Gln51Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Gln51Pro Rv0678_p.Gln51Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 901 1247 0 0 0.0040858359972341 0.99839871897518 0.994227708034801 0.999806018576913 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.38115169544997 0.512872834309089 156.5 299 False False 0 0 0 0 0 0 0 0 0 7.38115169544997 0 0 0.0040858359972341 0.99839871897518 0.994227708034801 0.999806018576913 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Gln76Arg Rv0678_p.Gln76Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 1034 12950 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999922785885259 0.999569866411227 0.99999804510978 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 12.5241779497098 0.159396979672639 974.620016429296 0.142533667024192 158.5 1032 False False 12.5241779497098 0.159396979672639 974.620016429296 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Gln76Glu Rv0678_p.Gln76Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Gln76Lys Rv0678_p.Gln76Lys 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 2 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Gln76* Rv0678_p.Gln76* 1 stop_gained (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 1033 12951 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 2.35115346086273 Inf 0.00547148098095541 62.5 1032 False False Inf 2.35115346086273 Inf 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 899 1249 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.260427478737382 Inf 0.175506184596404 63 299 False False 0 0 0 0 0 0 0 Inf 0.260427478737382 Inf 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI AwRI by relaxed thresholds (not endorsed) no E, O 5 +Bedaquiline Rv0678 p.Glu104Asp Rv0678_p.Glu104Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 0 0 0.975 0 0 0.975 0 0 54.0184755945099 1 186 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Glu104Gly Rv0678_p.Glu104Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Glu104Lys Rv0678_p.Glu104Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 1 1034 12950 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999922785885259 0.999569866411227 0.99999804510978 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.320822480694416 Inf 0.0740078655702538 150 1032 False False 12.5241779497098 0.159396979672639 974.620016429296 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 1 900 1248 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 0.99919935948759 0.995547271980628 0.999979729742686 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.035515837450779 Inf 0.419264774313634 151 299 False False 0 0 0 0 0 0 0 1.38666666666666 0.0176530068458996 108.845447474822 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 0.99919935948759 0.995547271980628 0.999979729742686 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Glu113Lys Rv0678_p.Glu113Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Glu113* Rv0678_p.Glu113* 1 stop_gained (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 1033 12951 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 2.35115346086273 Inf 0.00547148098095541 62.5 1032 False False Inf 2.35115346086273 Inf 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 899 1249 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.260427478737382 Inf 0.175506184596404 63 299 False False 0 0 0 0 0 0 0 Inf 0.260427478737382 Inf 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI AwRI by relaxed thresholds (not endorsed) no E, O 5 +Bedaquiline Rv0678 p.Glu138* Rv0678_p.Glu138* 1 stop_gained (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 1034 12950 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999922785885259 0.999569866411227 0.99999804510978 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 12.5241779497098 0.159396979672639 974.620016429296 0.142533667024192 158.5 1032 False False 12.5241779497098 0.159396979672639 974.620016429296 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Bedaquiline Rv0678 p.Glu147Asp Rv0678_p.Glu147Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 1034 12950 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999922785885259 0.999569866411227 0.99999804510978 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 613 1032 False False 12.5241779497098 0.159396979672639 974.620016429296 0 0 0.00356122541865182 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 213 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0 0 0.00409036651757122 1 0.997050890854678 1 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Glu147* Rv0678_p.Glu147* 1 stop_gained (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 602 1032 False False Inf 0.320847254634342 Inf 0 0 0.00356122541865182 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 204 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0 0 0.00409036651757122 1 0.997050890854678 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Bedaquiline Rv0678 p.Glu21Lys Rv0678_p.Glu21Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Glu49fs Rv0678_p.Glu49fs 1 frameshift (see "Genomic_coordinates" sheet) 1 161 138 23 142 26 893 12925 0.13719806763285 0.11680916524711 0.159674372343544 0.997992433016755 0.99705982312981 0.998688184453792 0.845238095238095 0.781518017202268 0.896344932978085 0.857142857142857 0.793393161754229 0.907235319446708 0.841463414634146 0.776399463228057 0.893748682208366 86.8421052631578 55.1598707090359 142.760873280905 6.96483918703367e-134 2 1032 True False 79.0485829959514 51.4197258952845 125.34887028816 0.133850630455868 0.113650290296475 0.156166551721714 0.997992433016755 0.99705982312981 0.998688184453792 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 131 129 2 132 3 769 1246 0.146503884572697 0.124045204324088 0.171301306013595 0.99759807846277 0.992996755835892 0.999504391864096 0.977777777777777 0.936431598185667 0.995393587104005 0.98473282442748 0.945938619108438 0.998145696828194 0.977272727272727 0.935018504630827 0.995288340968344 104.50845253576 28.1528209865173 857.505031700972 1.64669976113595e-48 2 299 True False 0 0 0 0 0 0 0 71.2925877763329 23.6939874290514 348.934172296042 0.143652561247216 0.121354574055896 0.168316717630016 0.99759807846277 0.992996755835892 0.999504391864096 23 1) Assoc w R Can only confer resistance if genetically linked to a functional MmpL5 UP from Uncertain to AwR yes E 4 +Bedaquiline Rv0678 p.Glu55Asp Rv0678_p.Glu55Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 14 0 14 0 14 1035 12937 0 0 0.00355779074923997 0.998919002393637 0.998186934193946 0.999408886519908 0 0 0.231635761650116 0 0 0.231635761650116 0 0 0.231635761650116 0 0 3.77462001277442 0.618484509170983 179 1032 False False 0 0 3.77462001277442 0 0 0.00355779074923997 0.998919002393637 0.998186934193946 0.999408886519908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 15 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Glu55fs Rv0678_p.Glu55fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Bedaquiline Rv0678 p.Gly103Arg Rv0678_p.Gly103Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Gly103Ser Rv0678_p.Gly103Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Gly11fs Rv0678_p.Gly11fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 UP from Uncertain to AwRI no E 4 +Bedaquiline Rv0678 p.Gly121Arg Rv0678_p.Gly121Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 10 9 1 9 1 1026 12950 0.00869565217391304 0.003983694112966 0.0164426238532791 0.999922785885259 0.999569866411227 0.99999804510978 0.9 0.554983882971804 0.997471421455538 0.9 0.554983882971804 0.997471421455538 0.9 0.554983882971804 0.997471421455538 113.59649122807 15.704412722481 4822.42117436137 6.01877976530644e-10 11.5 1032 True False 113.59649122807 15.704412722481 4822.42117436137 0.00869565217391304 0.003983694112966 0.0164426238532791 0.999922785885259 0.999569866411227 0.99999804510978 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 8 8 0 8 0 893 1249 0.00887902330743618 0.00384090311990167 0.0174199077138292 1 0.997050890854678 1 1 0.63058335244718 1 1 0.63058335244718 1 1 0.63058335244718 1 Inf 2.37877235677569 Inf 0.000934155494460586 12.5 299 True False 0 0 0 0 0 0 0 Inf 2.37877235677569 Inf 0.00887902330743618 0.00384090311990167 0.0174199077138292 1 0.997050890854678 1 1 1) Assoc w R Can only confer resistance if genetically linked to a functional MmpL5 UP from Uncertain to AwR yes E 4 +Bedaquiline Rv0678 p.Gly162Glu Rv0678_p.Gly162Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 616 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 15 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Gly24Arg Rv0678_p.Gly24Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Gly24Cys Rv0678_p.Gly24Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Gly25Asp Rv0678_p.Gly25Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 2 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Gly25Cys Rv0678_p.Gly25Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Gly41Asp Rv0678_p.Gly41Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 4 0 4 0 1031 12951 0.0038647342995169 0.00105398325986622 0.009865452176262 1 0.999715206999795 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 8.27463359653372 Inf 2.98299922003679e-05 27.5 1032 True False Inf 8.27463359653372 Inf 0.0038647342995169 0.00105398325986622 0.009865452176262 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 4 0 4 0 897 1249 0.00443951165371809 0.00121090206228936 0.0113275932937957 1 0.997050890854678 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 0.916560415731825 Inf 0.0307228946711506 27 299 False False 0 0 0 0 0 0 0 Inf 0.916560415731825 Inf 0.00443951165371809 0.00121090206228936 0.0113275932937957 1 0.997050890854678 1 NA 3) Uncertain significance New Uncertain AwRI by relaxed thresholds (not endorsed) yes O 0 +Bedaquiline Rv0678 p.Gly41fs Rv0678_p.Gly41fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 604 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Bedaquiline Rv0678 p.Gly65Arg Rv0678_p.Gly65Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Gly65Glu Rv0678_p.Gly65Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 3 0 3 0 1032 12951 0.00289855072463768 0.000598150191171612 0.00844722324607505 1 0.999715206999795 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 5.17684059997845 Inf 0.000404179051296263 37.5 1032 True False Inf 5.17684059997845 Inf 0.00289855072463768 0.000598150191171612 0.00844722324607505 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 3 0 3 0 898 1249 0.00332963374028856 0.000687177581788976 0.00969950356574711 1 0.997050890854678 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.573338395820229 Inf 0.0734544040745661 38 299 False False 0 0 0 0 0 0 0 Inf 0.573338395820229 Inf 0.00332963374028856 0.000687177581788976 0.00969950356574711 1 0.997050890854678 1 NA 3) Uncertain significance New Uncertain AwRI by relaxed thresholds (not endorsed) yes O 0 +Bedaquiline Rv0678 p.Gly78Arg Rv0678_p.Gly78Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 1033 12951 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 2.35115346086273 Inf 0.00547148098095541 62.5 1032 False False Inf 2.35115346086273 Inf 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 899 1249 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.260427478737382 Inf 0.175506184596404 63 299 False False 0 0 0 0 0 0 0 Inf 0.260427478737382 Inf 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 NA 3) Uncertain significance New Uncertain AwRI by relaxed thresholds (not endorsed) yes O 0 +Bedaquiline Rv0678 p.Gly78Trp Rv0678_p.Gly78Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Gly87Arg Rv0678_p.Gly87Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 1034 12950 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999922785885259 0.999569866411227 0.99999804510978 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 484.788082433345 1 426 1032 False False 12.5241779497098 0.159396979672639 974.620016429296 0 0 0.00356122541865182 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 207 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0 0 0.00409036651757122 1 0.997050890854678 1 25 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Gly87Trp Rv0678_p.Gly87Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 0 0 0.975 0 0 0.975 0 0 54.0184755945099 1 186 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Ile108Thr Rv0678_p.Ile108Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 484.286119137424 1 426 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Ile108Val Rv0678_p.Ile108Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 1034 12949 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999845571770519 0.999442264649511 0.999981297477798 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 484.750933473082 1 426 1032 False False 6.26160541586073 0.106032338278929 120.386237357489 0 0 0.00356122541865182 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 209 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0 0 0.00409036651757122 1 0.997050890854678 1 NA 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Ile16fs Rv0678_p.Ile16fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 606 1032 False False Inf 0.320847254634342 Inf 0 0 0.00356122541865182 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 206 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0 0 0.00409036651757122 1 0.997050890854678 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Bedaquiline Rv0678 p.Ile16Ser Rv0678_p.Ile16Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Ile67fs Rv0678_p.Ile67fs 1 frameshift (see "Genomic_coordinates" sheet) 1 67 51 16 52 35 983 12916 0.0502415458937198 0.0377471124029909 0.0653661388760341 0.997297505984094 0.996243470143756 0.998116914027089 0.597701149425287 0.48706889314851 0.701485275828235 0.761194029850746 0.641367506679083 0.856912294723573 0.593023255813953 0.481694692718172 0.697755401160701 41.8817395727365 23.3869376536064 78.9975148318299 2.44739206872822e-44 4 1032 True False 19.5213486411858 12.398736004241 31.026540601653 0.0493230174081237 0.0369414543104933 0.0643437257442377 0.997297505984094 0.996243470143756 0.998116914027089 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 47 45 2 46 3 855 1246 0.051054384017758 0.0376172781034644 0.0675151075130632 0.99759807846277 0.992996755835892 0.999504391864096 0.938775510204081 0.831341099297698 0.987191578681721 0.957446808510638 0.854594754511786 0.994804416823256 0.9375 0.828040069209429 0.986920755590447 32.7894736842105 8.51604053966229 281.787144800162 2.03473513894027e-15 3 299 True False 0 0 0 0 0 0 0 22.3454191033138 7.14054213084112 112.830221992129 0.05 0.0367007704696669 0.0663347800879441 0.99759807846277 0.992996755835892 0.999504391864096 88 1) Assoc w R Can only confer resistance if genetically linked to a functional MmpL5 New AwR yes E 5 +Bedaquiline Rv0678 p.Ile67Leu Rv0678_p.Ile67Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 1033 12951 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 2.35115346086273 Inf 0.00547148098095541 62.5 1032 False False Inf 2.35115346086273 Inf 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 NA 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Bedaquiline Rv0678 p.Ile67Met Rv0678_p.Ile67Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Ile67Ser Rv0678_p.Ile67Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 12 12 0 12 0 1023 12951 0.0115942028985507 0.00600484798029965 0.0201650768479061 1 0.999715206999795 1 1 0.735351530602948 1 1 0.735351530602948 1 1 0.735351530602948 1 Inf 35.1246913559842 Inf 2.54222875085401e-14 7 1032 True False Inf 35.1246913559842 Inf 0.0115942028985507 0.00600484798029965 0.0201650768479061 1 0.999715206999795 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 11 11 0 11 0 890 1249 0.0122086570477247 0.00610984137345395 0.02173945292066 1 0.997050890854678 1 1 0.715085847081845 1 1 0.715085847081845 1 1 0.715085847081845 1 Inf 3.50864469425713 Inf 6.75558997755072e-05 8 299 True False 0 0 0 0 0 0 0 Inf 3.50864469425713 Inf 0.0122086570477247 0.00610984137345395 0.02173945292066 1 0.997050890854678 1 NA Potentially inflated PPV 2) Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV. Can only confer resistance if genetically linked to a functional MmpL5 UP from Uncertain to AwRI AwRI by relaxed thresholds (not endorsed) yes Pot. Infl. PPV C, E, O 4 +Bedaquiline Rv0678 p.Ile80fs Rv0678_p.Ile80fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 UP from Uncertain to AwRI no E 4 +Bedaquiline Rv0678 p.Ile80Met Rv0678_p.Ile80Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Ile80Ser Rv0678_p.Ile80Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Leu117Arg Rv0678_p.Leu117Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 12 8 4 8 4 1027 12947 0.00772946859903381 0.00334277076300263 0.0151730581725558 0.999691143541039 0.99920939533685 0.999915840803364 0.666666666666666 0.348875506418814 0.900753908850416 0.666666666666666 0.348875506418814 0.900753908850416 0.666666666666666 0.348875506418814 0.900753908850416 25.2132424537487 6.73648881114847 114.796190294378 3.31507066753597e-07 17 1032 True False 25.2132424537487 6.73648881114847 114.796190294378 0.00772946859903381 0.00334277076300263 0.0151730581725558 0.999691143541039 0.99920939533685 0.999915840803364 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 8 8 0 8 0 893 1249 0.00887902330743618 0.00384090311990167 0.0174199077138292 1 0.997050890854678 1 1 0.63058335244718 1 1 0.63058335244718 1 1 0.63058335244718 1 Inf 2.37877235677569 Inf 0.000934155494460586 12.5 299 True False 0 0 0 0 0 0 0 Inf 2.37877235677569 Inf 0.00887902330743618 0.00384090311990167 0.0174199077138292 1 0.997050890854678 1 17 1) Assoc w R Can only confer resistance if genetically linked to a functional MmpL5 UP from Uncertain to AwR yes E 4 +Bedaquiline Rv0678 p.Leu117fs Rv0678_p.Leu117fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Bedaquiline Rv0678 p.Leu117Pro Rv0678_p.Leu117Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 1034 12950 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999922785885259 0.999569866411227 0.99999804510978 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 484.788082433345 1 426 1032 False False 12.5241779497098 0.159396979672639 974.620016429296 0 0 0.00356122541865182 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 214 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0 0 0.00409036651757122 1 0.997050890854678 1 2 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Leu122Pro Rv0678_p.Leu122Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 1033 12951 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 2.35115346086273 Inf 0.00547148098095541 62.5 1032 False False Inf 2.35115346086273 Inf 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 899 1249 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.260427478737382 Inf 0.175506184596404 63 299 False False 0 0 0 0 0 0 0 Inf 0.260427478737382 Inf 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 1 3) Uncertain significance New Uncertain AwRI by relaxed thresholds (not endorsed) yes O 0 +Bedaquiline Rv0678 p.Leu125fs Rv0678_p.Leu125fs 1 frameshift (see "Genomic_coordinates" sheet) 1 3 2 1 2 1 1033 12950 0.00193236714975845 0.000234104356582827 0.00696277826632085 0.999922785885259 0.999569866411227 0.99999804510978 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 25.0726040658276 1.30341687247419 1463.2013999217 0.0156060848402737 83 1032 False False 25.0726040658276 1.30341687247419 1463.2013999217 0.00193236714975845 0.000234104356582827 0.00696277826632085 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 899 1249 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.260427478737382 Inf 0.175506184596404 63 299 False False 0 0 0 0 0 0 0 Inf 0.260427478737382 Inf 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 UP from Uncertain to AwRI AwRI by relaxed thresholds (not endorsed) no E, O 4 +Bedaquiline Rv0678 p.Leu136Pro Rv0678_p.Leu136Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 NA 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Leu142Arg Rv0678_p.Leu142Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 2 2 7 2 1028 12949 0.00676328502415459 0.00272338773585253 0.0138850260502618 0.999845571770519 0.999442264649511 0.999981297477798 0.777777777777777 0.399906426283687 0.971855026522101 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 12.5963035019455 0.911777940674213 173.72729083733 0.0294332954200931 88 1032 False False 44.0870622568093 8.37393422660993 434.8895621762 0.00194174757281553 0.000235241203977001 0.00699649243597766 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 3) Uncertain significance New Uncertain AwRI by relaxed thresholds (not endorsed) yes O 0 +Bedaquiline Rv0678 p.Leu142fs Rv0678_p.Leu142fs 1 frameshift (see "Genomic_coordinates" sheet) 1 15 14 1 14 3 1021 12948 0.0135265700483091 0.00741430167134659 0.0225912326269148 0.999768357655779 0.999323193486146 0.999952227231941 0.823529411764705 0.565682127155716 0.962014931929374 0.933333333333333 0.680515433421696 0.998313569758647 0.823529411764705 0.565682127155716 0.962014931929374 177.543584720861 26.9562254725174 7140.32873109015 1.90637645058038e-15 5 1032 True False 59.1811949069539 16.4652624085942 324.56896713689 0.0135265700483091 0.00741430167134659 0.0225912326269148 0.999768357655779 0.999323193486146 0.999952227231941 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 15 14 1 14 1 887 1248 0.0155382907880133 0.00852028376737126 0.0259333040139294 0.99919935948759 0.995547271980628 0.999979729742686 0.933333333333333 0.680515433421696 0.998313569758647 0.933333333333333 0.680515433421696 0.998313569758647 0.933333333333333 0.680515433421696 0.998313569758647 19.6978579481398 2.98359574624024 830.328406255769 4.46156301696848e-05 6 299 True False 0 0 0 0 0 0 0 19.6978579481398 2.98359574624024 830.328406255769 0.0155382907880133 0.00852028376737126 0.0259333040139294 0.99919935948759 0.995547271980628 0.999979729742686 NA Potentially inflated PPV 2) Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV. Can only confer resistance if genetically linked to a functional MmpL5 New AwRI AwRI by relaxed thresholds (not endorsed) no Pot. Infl. PPV C, E, O 5 +Bedaquiline Rv0678 p.Leu142Pro Rv0678_p.Leu142Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Leu143fs Rv0678_p.Leu143fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Bedaquiline Rv0678 p.Leu32fs Rv0678_p.Leu32fs 1 frameshift (see "Genomic_coordinates" sheet) 2 4 4 0 4 0 1031 12951 0.0038647342995169 0.00105398325986622 0.009865452176262 1 0.999715206999795 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 8.27463359653372 Inf 2.98299922003679e-05 27.5 1032 True False Inf 8.27463359653372 Inf 0.0038647342995169 0.00105398325986622 0.009865452176262 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 4 4 0 4 0 897 1249 0.00443951165371809 0.00121090206228936 0.0113275932937957 1 0.997050890854678 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 0.916560415731825 Inf 0.0307228946711506 27 299 False False 0 0 0 0 0 0 0 Inf 0.916560415731825 Inf 0.00443951165371809 0.00121090206228936 0.0113275932937957 1 0.997050890854678 1 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI AwRI by relaxed thresholds (not endorsed) no E, O 5 +Bedaquiline Rv0678 p.Leu32Ser Rv0678_p.Leu32Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 5 1 5 1 1030 12950 0.00483091787439613 0.00157039035246783 0.0112374718131471 0.999922785885259 0.999569866411227 0.99999804510978 0.833333333333333 0.358765421002325 0.99578925548551 0.833333333333333 0.358765421002325 0.99578925548551 0.833333333333333 0.358765421002325 0.99578925548551 62.8640776699029 7.01942689733694 2917.25851196433 1.23873274862375e-05 25 1032 True False 62.8640776699029 7.01942689733694 2917.25851196433 0.00483091787439613 0.00157039035246783 0.0112374718131471 0.999922785885259 0.999569866411227 0.99999804510978 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance 1 5 5 0 5 0 896 1249 0.00554938956714761 0.0018042535136792 0.0129025590758184 1 0.997050890854678 1 1 0.478176249895018 1 1 0.478176249895018 1 1 0.478176249895018 1 Inf 1.27344498734659 Inf 0.0128417691146421 23 299 False False 0 0 0 0 0 0 0 Inf 1.27344498734659 Inf 0.00554938956714761 0.0018042535136792 0.0129025590758184 1 0.997050890854678 1 3 Evidence from ALL dataset only 2) Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV. Can only confer resistance if genetically linked to a functional MmpL5 UP from Uncertain to AwRI AwRI by relaxed thresholds (not endorsed) yes ALL only C, E, O 4 +Bedaquiline Rv0678 p.Leu35Trp Rv0678_p.Leu35Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 1033 12951 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 2.35115346086273 Inf 0.00547148098095541 62.5 1032 False False Inf 2.35115346086273 Inf 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 899 1249 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.260427478737382 Inf 0.175506184596404 63 299 False False 0 0 0 0 0 0 0 Inf 0.260427478737382 Inf 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 NA 3) Uncertain significance New Uncertain AwRI by relaxed thresholds (not endorsed) yes O 0 +Bedaquiline Rv0678 p.Leu40Met Rv0678_p.Leu40Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Leu40Phe Rv0678_p.Leu40Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 1033 12951 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 2.35115346086273 Inf 0.00547148098095541 62.5 1032 False False Inf 2.35115346086273 Inf 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 NA 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Bedaquiline Rv0678 p.Leu40Ser Rv0678_p.Leu40Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Leu40Val Rv0678_p.Leu40Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 10 0 10 0 10 1035 12941 0 0 0.00355779074923997 0.999227858852598 0.998580464895556 0.999629668183042 0 0 0.30849710781876 0 0 0.30849710781876 0 0 0.30849710781876 0 0 5.58682568371909 1 426 1032 False False 0 0 5.58682568371909 0 0 0.00355779074923997 0.999227858852598 0.998580464895556 0.999629668183042 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Leu43fs Rv0678_p.Leu43fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Bedaquiline Rv0678 p.Leu44fs Rv0678_p.Leu44fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 1033 12951 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 2.35115346086273 Inf 0.00547148098095541 62.5 1032 False False Inf 2.35115346086273 Inf 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 899 1249 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.260427478737382 Inf 0.175506184596404 63 299 False False 0 0 0 0 0 0 0 Inf 0.260427478737382 Inf 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI AwRI by relaxed thresholds (not endorsed) no E, O 5 +Bedaquiline Rv0678 p.Leu56fs Rv0678_p.Leu56fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 1033 12951 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 2.35115346086273 Inf 0.00547148098095541 62.5 1032 False False Inf 2.35115346086273 Inf 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 899 1249 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.260427478737382 Inf 0.175506184596404 63 299 False False 0 0 0 0 0 0 0 Inf 0.260427478737382 Inf 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI AwRI by relaxed thresholds (not endorsed) no E, O 5 +Bedaquiline Rv0678 p.Leu56Pro Rv0678_p.Leu56Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 0 0 0.975 0 0 0.975 0 0 54.0184755945099 1 186 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Leu60Gln Rv0678_p.Leu60Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 1033 12951 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 2.35115346086273 Inf 0.00547148098095541 62.5 1032 False False Inf 2.35115346086273 Inf 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 899 1249 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.260427478737382 Inf 0.175506184596404 63 299 False False 0 0 0 0 0 0 0 Inf 0.260427478737382 Inf 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 NA 3) Uncertain significance New Uncertain AwRI by relaxed thresholds (not endorsed) yes O 0 +Bedaquiline Rv0678 p.Leu60Pro Rv0678_p.Leu60Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 3 0 1032 12951 0.00289855072463768 0.000598150191171612 0.00844722324607505 1 0.999715206999795 1 1 0.292401773821286 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 2.35343738380065 Inf 0.00546168909316863 48 1032 False False Inf 5.17684059997845 Inf 0.00193423597678916 0.000234330846166462 0.00696949508177313 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 3 0 898 1249 0.00332963374028856 0.000687177581788976 0.00969950356574711 1 0.997050890854678 1 1 0.292401773821286 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.260717030284841 Inf 0.17527965456195 49 299 False False 0 0 0 0 0 0 0 Inf 0.573338395820229 Inf 0.00222222222222222 0.000269234810373886 0.00800416404484305 1 0.997050890854678 1 NA 3) Uncertain significance New Uncertain AwRI by relaxed thresholds (not endorsed) yes O 0 +Bedaquiline Rv0678 p.Leu74Met Rv0678_p.Leu74Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Leu83fs Rv0678_p.Leu83fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Bedaquiline Rv0678 p.Leu83His Rv0678_p.Leu83His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 0 0 0.975 0 0 0.975 0 0 54.0184755945099 1 186 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Leu83Pro Rv0678_p.Leu83Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 1 2 1034 12949 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999845571770519 0.999442264649511 0.999981297477798 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 6.26160541586073 0.106032338278929 120.386237357489 0.205997458116152 170 1032 False False 6.26160541586073 0.106032338278929 120.386237357489 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 NA 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Leu95Ser Rv0678_p.Leu95Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 2 1 2 1 1033 12950 0.00193236714975845 0.000234104356582827 0.00696277826632085 0.999922785885259 0.999569866411227 0.99999804510978 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 25.0726040658276 1.30341687247419 1463.2013999217 0.0156060848402737 83 1032 False False 25.0726040658276 1.30341687247419 1463.2013999217 0.00193236714975845 0.000234104356582827 0.00696277826632085 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 2 1 2 1 899 1248 0.00221975582685904 0.000268935866794296 0.0079953061571445 0.99919935948759 0.995547271980628 0.999979729742686 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 2.77641824249165 0.144259516740608 163.770215780116 0.57546459302915 164 299 False False 0 0 0 0 0 0 0 2.77641824249165 0.144259516740608 163.770215780116 0.00221975582685904 0.000268935866794296 0.0079953061571445 0.99919935948759 0.995547271980628 0.999979729742686 1 3) Uncertain significance New Uncertain AwRI by relaxed thresholds (not endorsed) yes O 0 +Bedaquiline Rv0678 p.Met1? Rv0678_p.Met1? 1 start_lost (see "Genomic_coordinates" sheet) 1 3 2 1 2 1 1033 12950 0.00193236714975845 0.000234104356582827 0.00696277826632085 0.999922785885259 0.999569866411227 0.99999804510978 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 25.0726040658276 1.30341687247419 1463.2013999217 0.0156060848402737 83 1032 False False 25.0726040658276 1.30341687247419 1463.2013999217 0.00193236714975845 0.000234104356582827 0.00696277826632085 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 899 1249 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.260427478737382 Inf 0.175506184596404 63 299 False False 0 0 0 0 0 0 0 Inf 0.260427478737382 Inf 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI AwRI by relaxed thresholds (not endorsed) no E, O 5 +Bedaquiline Rv0678 p.Met10fs Rv0678_p.Met10fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Bedaquiline Rv0678 p.Met10Ile Rv0678_p.Met10Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Met111fs Rv0678_p.Met111fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Bedaquiline Rv0678 p.Met139Ile Rv0678_p.Met139Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 2 1 2 1 1033 12950 0.00193236714975845 0.000234104356582827 0.00696277826632085 0.999922785885259 0.999569866411227 0.99999804510978 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 25.0726040658276 1.30341687247419 1463.2013999217 0.0156060848402737 83 1032 False False 25.0726040658276 1.30341687247419 1463.2013999217 0.00193236714975845 0.000234104356582827 0.00696277826632085 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Bedaquiline Rv0678 p.Met139Thr Rv0678_p.Met139Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 2 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Met146fs Rv0678_p.Met146fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 1033 12951 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.32115755182578 Inf 0.073936360386128 93 1032 False False Inf 2.35115346086273 Inf 0.000967117988394584 2.4485007765631e-05 0.00537653963257833 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 899 1249 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0355837903294945 Inf 0.418799441600744 84 299 False False 0 0 0 0 0 0 0 Inf 0.260427478737382 Inf 0.00111111111111111 2.81305020903278e-05 0.00617501455708113 1 0.997050890854678 1 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Bedaquiline Rv0678 p.Met146Thr Rv0678_p.Met146Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 48 11 37 11 37 1024 12914 0.0106280193236714 0.00531707433425849 0.0189367299858332 0.997143077754613 0.996064238066014 0.997987689712242 0.229166666666666 0.120330166825783 0.37312024731586 0.229166666666666 0.120330166825783 0.37312024731586 0.229166666666666 0.120330166825783 0.37312024731586 3.74931376689189 1.71950198379053 7.53260647374371 0.000612967792542935 42 1032 True False 3.74931376689189 1.71950198379053 7.53260647374371 0.0106280193236714 0.00531707433425849 0.0189367299858332 0.997143077754613 0.996064238066014 0.997987689712242 3) Uncertain significance 1) Assoc w R WHO 1) Assoc w R 1 11 11 0 11 0 890 1249 0.0122086570477247 0.00610984137345395 0.02173945292066 1 0.997050890854678 1 1 0.715085847081845 1 1 0.715085847081845 1 1 0.715085847081845 1 Inf 3.50864469425713 Inf 6.75558997755072e-05 8 299 True False 0 0 0 0 0 0 0 Inf 3.50864469425713 Inf 0.0122086570477247 0.00610984137345395 0.02173945292066 1 0.997050890854678 1 20 Potentially inflated PPV 2) Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV. Can only confer resistance if genetically linked to a functional MmpL5 UP from Uncertain to AwRI AwRI by relaxed thresholds (not endorsed) yes Pot. Infl. PPV C, E, O 4 +Bedaquiline Rv0678 p.Met17Val Rv0678_p.Met17Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 66.5980571122582 1 426 1032 False False 0 0 30.2740898875531 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Met23Leu Rv0678_p.Met23Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 1035 12947 0 0 0.00355779074923997 0.999691143541039 0.99920939533685 0.999915840803364 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 66.5929351784659 1 426 1032 False False 0 0 18.9615575493326 0 0 0.00355779074923997 0.999691143541039 0.99920939533685 0.999915840803364 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Met23Val Rv0678_p.Met23Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 1035 12947 0 0 0.00355779074923997 0.999691143541039 0.99920939533685 0.999915840803364 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 18.9615575493326 1 426 1032 False False 0 0 18.9615575493326 0 0 0.00355779074923997 0.999691143541039 0.99920939533685 0.999915840803364 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Met73Ile Rv0678_p.Met73Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 30.2740898875531 1 426 1032 False False 0 0 30.2740898875531 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Phe100Ile Rv0678_p.Phe100Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Phe19Leu Rv0678_p.Phe19Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 608 1032 False False Inf 0.320847254634342 Inf 0 0 0.00356122541865182 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 210 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0 0 0.00409036651757122 1 0.997050890854678 1 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Phe19Ser Rv0678_p.Phe19Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 1034 12950 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999922785885259 0.999569866411227 0.99999804510978 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 12.5241779497098 0.159396979672639 974.620016429296 0.142533667024192 158.5 1032 False False 12.5241779497098 0.159396979672639 974.620016429296 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Phe79Leu Rv0678_p.Phe79Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 1033 12951 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 2.35115346086273 Inf 0.00547148098095541 62.5 1032 False False Inf 2.35115346086273 Inf 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 899 1249 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.260427478737382 Inf 0.175506184596404 63 299 False False 0 0 0 0 0 0 0 Inf 0.260427478737382 Inf 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 NA 3) Uncertain significance New Uncertain AwRI by relaxed thresholds (not endorsed) yes O 0 +Bedaquiline Rv0678 p.Phe93Leu Rv0678_p.Phe93Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 2 1 2 1 1033 12950 0.00193236714975845 0.000234104356582827 0.00696277826632085 0.999922785885259 0.999569866411227 0.99999804510978 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 25.0726040658276 1.30341687247419 1463.2013999217 0.0156060848402737 83 1032 False False 25.0726040658276 1.30341687247419 1463.2013999217 0.00193236714975845 0.000234104356582827 0.00696277826632085 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 2 1 2 1 899 1248 0.00221975582685904 0.000268935866794296 0.0079953061571445 0.99919935948759 0.995547271980628 0.999979729742686 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 2.77641824249165 0.144259516740608 163.770215780116 0.57546459302915 164 299 False False 0 0 0 0 0 0 0 2.77641824249165 0.144259516740608 163.770215780116 0.00221975582685904 0.000268935866794296 0.0079953061571445 0.99919935948759 0.995547271980628 0.999979729742686 3 3) Uncertain significance New Uncertain AwRI by relaxed thresholds (not endorsed) yes O 0 +Bedaquiline Rv0678 p.Phe93Ser Rv0678_p.Phe93Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 1034 12950 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999922785885259 0.999569866411227 0.99999804510978 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 12.5241779497098 0.159396979672639 974.620016429296 0.142533667024192 158.5 1032 False False 12.5241779497098 0.159396979672639 974.620016429296 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Pro129fs Rv0678_p.Pro129fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 1033 12951 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 2.35115346086273 Inf 0.00547148098095541 62.5 1032 False False Inf 2.35115346086273 Inf 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 899 1249 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.260427478737382 Inf 0.175506184596404 63 299 False False 0 0 0 0 0 0 0 Inf 0.260427478737382 Inf 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI AwRI by relaxed thresholds (not endorsed) no E, O 5 +Bedaquiline Rv0678 p.Pro14Leu Rv0678_p.Pro14Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 607 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Pro14Ser Rv0678_p.Pro14Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 605 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Pro48fs Rv0678_p.Pro48fs 1 frameshift (see "Genomic_coordinates" sheet) 1 18 15 3 17 3 1018 12948 0.0164251207729468 0.00959659763082474 0.026168314146062 0.999768357655779 0.999323193486146 0.999952227231941 0.85 0.621073173454686 0.967929062814536 0.833333333333333 0.585822508605226 0.964214916878425 0.833333333333333 0.585822508605226 0.964214916878425 63.5952848722986 17.9358501738573 340.346048404182 6.38930780282289e-15 6 1032 True False 72.0746561886051 20.7861981732458 382.40426914229 0.0145208131655372 0.00814936062201832 0.0238369324048975 0.999768357655779 0.999323193486146 0.999952227231941 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 16 15 1 17 1 884 1248 0.0188679245283018 0.0110287187897308 0.0300379546681907 0.99919935948759 0.995547271980628 0.999979729742686 0.944444444444444 0.727056400326631 0.99859444383263 0.9375 0.697679261565468 0.998418888277234 0.9375 0.697679261565468 0.998418888277234 21.1764705882352 3.2432245045732 888.491000267262 1.93486035331956e-05 5 299 True False 0 0 0 0 0 0 0 24 3.74278898395483 999.111109743494 0.0166852057842046 0.00936788162517711 0.0273705851609428 0.99919935948759 0.995547271980628 0.999979729742686 1 Potentially inflated PPV 2) Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV. Can only confer resistance if genetically linked to a functional MmpL5 UP from Uncertain to AwRI AwRI by relaxed thresholds (not endorsed) no Pot. Infl. PPV C, E, O 4 +Bedaquiline Rv0678 p.Pro48Leu Rv0678_p.Pro48Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 3 1 3 1 1032 12950 0.00289855072463768 0.000598150191171612 0.00844722324607505 0.999922785885259 0.999569866411227 0.99999804510978 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 37.6453488372093 3.01751469574157 1949.96293381012 0.00152722622858395 44.5 1032 True False 37.6453488372093 3.01751469574157 1949.96293381012 0.00289855072463768 0.000598150191171612 0.00844722324607505 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 899 1249 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.260427478737382 Inf 0.175506184596404 63 299 False False 0 0 0 0 0 0 0 Inf 0.260427478737382 Inf 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 NA 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Bedaquiline Rv0678 p.Ser151Pro Rv0678_p.Ser151Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 1033 12951 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 2.35115346086273 Inf 0.00547148098095541 62.5 1032 False False Inf 2.35115346086273 Inf 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 899 1249 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.260427478737382 Inf 0.175506184596404 63 299 False False 0 0 0 0 0 0 0 Inf 0.260427478737382 Inf 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 1 3) Uncertain significance New Uncertain AwRI by relaxed thresholds (not endorsed) yes O 0 +Bedaquiline Rv0678 p.Ser158Arg Rv0678_p.Ser158Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Ser2Arg Rv0678_p.Ser2Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 30.2740898875531 1 426 1032 False False 0 0 30.2740898875531 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Ser2Ile Rv0678_p.Ser2Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 3 1 3 1 1032 12950 0.00289855072463768 0.000598150191171612 0.00844722324607505 0.999922785885259 0.999569866411227 0.99999804510978 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 37.6453488372093 3.01751469574157 1949.96293381012 0.00152722622858395 44.5 1032 True False 37.6453488372093 3.01751469574157 1949.96293381012 0.00289855072463768 0.000598150191171612 0.00844722324607505 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 3 0 3 0 898 1249 0.00332963374028856 0.000687177581788976 0.00969950356574711 1 0.997050890854678 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.573338395820229 Inf 0.0734544040745661 38 299 False False 0 0 0 0 0 0 0 Inf 0.573338395820229 Inf 0.00332963374028856 0.000687177581788976 0.00969950356574711 1 0.997050890854678 1 3 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Bedaquiline Rv0678 p.Ser31Gly Rv0678_p.Ser31Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 0 0 0.975 0 0 0.975 0 0 54.0184755945099 1 186 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Ser52Phe Rv0678_p.Ser52Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 1033 12951 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 2.35115346086273 Inf 0.00547148098095541 62.5 1032 False False Inf 2.35115346086273 Inf 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 899 1249 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.260427478737382 Inf 0.175506184596404 63 299 False False 0 0 0 0 0 0 0 Inf 0.260427478737382 Inf 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 NA 3) Uncertain significance New Uncertain AwRI by relaxed thresholds (not endorsed) yes O 0 +Bedaquiline Rv0678 p.Ser52Pro Rv0678_p.Ser52Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Ser52Tyr Rv0678_p.Ser52Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 0 0 0.975 0 0 0.975 0 0 54.0184755945099 1 186 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Ser53Leu Rv0678_p.Ser53Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 1033 12951 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.32115755182578 Inf 0.073936360386128 93 1032 False False Inf 2.35115346086273 Inf 0.000967117988394584 2.4485007765631e-05 0.00537653963257833 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 899 1249 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0355837903294945 Inf 0.418799441600744 84 299 False False 0 0 0 0 0 0 0 Inf 0.260427478737382 Inf 0.00111111111111111 2.81305020903278e-05 0.00617501455708113 1 0.997050890854678 1 3 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Ser53Pro Rv0678_p.Ser53Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 4 0 4 0 1031 12951 0.0038647342995169 0.00105398325986622 0.009865452176262 1 0.999715206999795 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 8.27463359653372 Inf 2.98299922003679e-05 27.5 1032 True False Inf 8.27463359653372 Inf 0.0038647342995169 0.00105398325986622 0.009865452176262 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 4 0 4 0 897 1249 0.00443951165371809 0.00121090206228936 0.0113275932937957 1 0.997050890854678 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 0.916560415731825 Inf 0.0307228946711506 27 299 False False 0 0 0 0 0 0 0 Inf 0.916560415731825 Inf 0.00443951165371809 0.00121090206228936 0.0113275932937957 1 0.997050890854678 1 NA 3) Uncertain significance New Uncertain AwRI by relaxed thresholds (not endorsed) yes O 0 +Bedaquiline Rv0678 p.Ser53* Rv0678_p.Ser53* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Bedaquiline Rv0678 p.Ser63Arg Rv0678_p.Ser63Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 2 1 2 1 1033 12950 0.00193236714975845 0.000234104356582827 0.00696277826632085 0.999922785885259 0.999569866411227 0.99999804510978 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 25.0726040658276 1.30341687247419 1463.2013999217 0.0156060848402737 83 1032 False False 25.0726040658276 1.30341687247419 1463.2013999217 0.00193236714975845 0.000234104356582827 0.00696277826632085 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 2 1 2 1 899 1248 0.00221975582685904 0.000268935866794296 0.0079953061571445 0.99919935948759 0.995547271980628 0.999979729742686 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 2.77641824249165 0.144259516740608 163.770215780116 0.57546459302915 164 299 False False 0 0 0 0 0 0 0 2.77641824249165 0.144259516740608 163.770215780116 0.00221975582685904 0.000268935866794296 0.0079953061571445 0.99919935948759 0.995547271980628 0.999979729742686 NA 3) Uncertain significance New Uncertain AwRI by relaxed thresholds (not endorsed) yes O 0 +Bedaquiline Rv0678 p.Ser63Gly Rv0678_p.Ser63Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 3 0 3 0 1032 12951 0.00289855072463768 0.000598150191171612 0.00844722324607505 1 0.999715206999795 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 5.17684059997845 Inf 0.000404179051296263 37.5 1032 True False Inf 5.17684059997845 Inf 0.00289855072463768 0.000598150191171612 0.00844722324607505 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 3 0 3 0 898 1249 0.00332963374028856 0.000687177581788976 0.00969950356574711 1 0.997050890854678 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.573338395820229 Inf 0.0734544040745661 38 299 False False 0 0 0 0 0 0 0 Inf 0.573338395820229 Inf 0.00332963374028856 0.000687177581788976 0.00969950356574711 1 0.997050890854678 1 NA 3) Uncertain significance New Uncertain AwRI by relaxed thresholds (not endorsed) yes O 0 +Bedaquiline Rv0678 p.Ser64Ile Rv0678_p.Ser64Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Ser68Asn Rv0678_p.Ser68Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Ser68fs Rv0678_p.Ser68fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Bedaquiline Rv0678 p.Ser68Gly Rv0678_p.Ser68Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Ser68Ile Rv0678_p.Ser68Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Ter166Argext*? Rv0678_p.Ter166Argext*? 1 stop_lost (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 611 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Thr33Ile Rv0678_p.Thr33Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Thr58Pro Rv0678_p.Thr58Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Thr69fs Rv0678_p.Thr69fs 1 frameshift (see "Genomic_coordinates" sheet) 1 3 3 0 3 0 1032 12951 0.00289855072463768 0.000598150191171612 0.00844722324607505 1 0.999715206999795 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 5.17684059997845 Inf 0.000404179051296263 37.5 1032 True False Inf 5.17684059997845 Inf 0.00289855072463768 0.000598150191171612 0.00844722324607505 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 3 0 3 0 898 1249 0.00332963374028856 0.000687177581788976 0.00969950356574711 1 0.997050890854678 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.573338395820229 Inf 0.0734544040745661 38 299 False False 0 0 0 0 0 0 0 Inf 0.573338395820229 Inf 0.00332963374028856 0.000687177581788976 0.00969950356574711 1 0.997050890854678 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI AwRI by relaxed thresholds (not endorsed) no E, O 5 +Bedaquiline Rv0678 p.Thr69Pro Rv0678_p.Thr69Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Thr91Ile Rv0678_p.Thr91Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 4 0 4 0 1031 12951 0.0038647342995169 0.00105398325986622 0.009865452176262 1 0.999715206999795 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 8.27463359653372 Inf 2.98299922003679e-05 27.5 1032 True False Inf 8.27463359653372 Inf 0.0038647342995169 0.00105398325986622 0.009865452176262 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 3 0 3 0 898 1249 0.00332963374028856 0.000687177581788976 0.00969950356574711 1 0.997050890854678 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.573338395820229 Inf 0.0734544040745661 38 299 False False 0 0 0 0 0 0 0 Inf 0.573338395820229 Inf 0.00332963374028856 0.000687177581788976 0.00969950356574711 1 0.997050890854678 1 NA 3) Uncertain significance New Uncertain AwRI by relaxed thresholds (not endorsed) yes O 0 +Bedaquiline Rv0678 p.Trp42Arg Rv0678_p.Trp42Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Trp42fs Rv0678_p.Trp42fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Bedaquiline Rv0678 p.Trp42* Rv0678_p.Trp42* 1 stop_gained (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 1033 12951 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 2.35115346086273 Inf 0.00547148098095541 62.5 1032 False False Inf 2.35115346086273 Inf 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 899 1249 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.260427478737382 Inf 0.175506184596404 63 299 False False 0 0 0 0 0 0 0 Inf 0.260427478737382 Inf 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI AwRI by relaxed thresholds (not endorsed) no E, O 5 +Bedaquiline Rv0678 p.Tyr145fs Rv0678_p.Tyr145fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Bedaquiline Rv0678 p.Tyr145His Rv0678_p.Tyr145His 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 614 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Tyr145* Rv0678_p.Tyr145* 1 stop_gained (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 1034 12950 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999922785885259 0.999569866411227 0.99999804510978 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 12.5241779497098 0.159396979672639 974.620016429296 0.142533667024192 158.5 1032 False False 12.5241779497098 0.159396979672639 974.620016429296 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Bedaquiline Rv0678 p.Tyr157fs Rv0678_p.Tyr157fs 1 frameshift (see "Genomic_coordinates" sheet) 1 5 5 0 5 0 1030 12951 0.00483091787439613 0.00157039035246783 0.0112374718131471 1 0.999715206999795 1 1 0.478176249895018 1 1 0.478176249895018 1 1 0.478176249895018 1 Inf 11.4983851517043 Inf 2.19959390348872e-06 22 1032 True False Inf 11.4983851517043 Inf 0.00483091787439613 0.00157039035246783 0.0112374718131471 1 0.999715206999795 1 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance 1 3 3 0 3 0 898 1249 0.00332963374028856 0.000687177581788976 0.00969950356574711 1 0.997050890854678 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.573338395820229 Inf 0.0734544040745661 38 299 False False 0 0 0 0 0 0 0 Inf 0.573338395820229 Inf 0.00332963374028856 0.000687177581788976 0.00969950356574711 1 0.997050890854678 1 NA Evidence from ALL dataset only 2) Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV. Can only confer resistance if genetically linked to a functional MmpL5 UP from Uncertain to AwRI AwRI by relaxed thresholds (not endorsed) no ALL only C, E, O 4 +Bedaquiline Rv0678 p.Tyr157Ser Rv0678_p.Tyr157Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 1 1033 12950 0.00193236714975845 0.000234104356582827 0.00696277826632085 0.999922785885259 0.999569866411227 0.99999804510978 0.666666666666666 0.0942993240502461 0.991596241340387 1 0.158113883008419 1 0.666666666666666 0.0942993240502461 0.991596241340387 Inf 2.35097122661017 Inf 0.00547226351542065 77 1032 False False 25.0726040658276 1.30341687247419 1463.2013999217 0.00193236714975845 0.000234104356582827 0.00696277826632085 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 1 899 1248 0.00221975582685904 0.000268935866794296 0.0079953061571445 0.99919935948759 0.995547271980628 0.999979729742686 0.666666666666666 0.0942993240502461 0.991596241340387 1 0.158113883008419 1 0.666666666666666 0.0942993240502461 0.991596241340387 Inf 0.260218898711111 Inf 0.175669598176103 77 299 False False 0 0 0 0 0 0 0 2.77641824249165 0.144259516740608 163.770215780116 0.00221975582685904 0.000268935866794296 0.0079953061571445 0.99919935948759 0.995547271980628 0.999979729742686 NA 3) Uncertain significance New Uncertain AwRI by relaxed thresholds (not endorsed) yes O 0 +Bedaquiline Rv0678 p.Tyr157* Rv0678_p.Tyr157* 1 stop_gained (see "Genomic_coordinates" sheet) 2 2 2 0 2 0 1033 12951 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 2.35115346086273 Inf 0.00547148098095541 62.5 1032 False False Inf 2.35115346086273 Inf 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 899 1249 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 208 299 False False 0 0 0 0 0 0 0 Inf 0.260427478737382 Inf 0 0 0.00409490709625158 1 0.997050890854678 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI AwRI by relaxed thresholds (not endorsed) no E, O 5 +Bedaquiline Rv0678 p.Tyr26Asp Rv0678_p.Tyr26Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 610 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Tyr26Cys Rv0678_p.Tyr26Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 615 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Tyr26His Rv0678_p.Tyr26His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Tyr92Cys Rv0678_p.Tyr92Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.320847254634342 Inf 0.0740025740025739 122 1032 False False Inf 0.320847254634342 Inf 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0355442960786845 Inf 0.41906976744186 118 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Tyr92fs Rv0678_p.Tyr92fs 1 frameshift (see "Genomic_coordinates" sheet) 1 8 5 3 5 4 1030 12947 0.00483091787439613 0.00157039035246783 0.0112374718131471 0.999691143541039 0.99920939533685 0.999915840803364 0.555555555555555 0.212008506778868 0.863004337734833 0.625 0.244863216366551 0.914766585862746 0.555555555555555 0.212008506778868 0.863004337734833 20.9498381877022 4.06711975401613 135.540743188736 0.000101926267661152 31 1032 True False 15.7123786407767 3.37456055720944 79.2329508702612 0.00483091787439613 0.00157039035246783 0.0112374718131471 0.999691143541039 0.99920939533685 0.999915840803364 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 4 1 4 2 897 1247 0.00443951165371809 0.00121090206228936 0.0113275932937957 0.99839871897518 0.994227708034801 0.999806018576913 0.666666666666666 0.222778095503512 0.956728131707258 0.8 0.28358206388191 0.994949236620532 0.666666666666666 0.222778095503512 0.956728131707258 5.56075808249721 0.548717722384054 273.68849238669 0.168244776430375 48 299 False False 0 0 0 0 0 0 0 2.7803790412486 0.397314242958189 30.7799921643675 0.00443951165371809 0.00121090206228936 0.0113275932937957 0.99839871897518 0.994227708034801 0.999806018576913 5 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 UP from Uncertain to AwRI AwRI by relaxed thresholds (not endorsed) no E, O 4 +Bedaquiline Rv0678 p.Tyr92* Rv0678_p.Tyr92* 1 stop_gained (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 1033 12951 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 2.35115346086273 Inf 0.00547148098095541 62.5 1032 False False Inf 2.35115346086273 Inf 0.00193236714975845 0.000234104356582827 0.00696277826632085 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 899 1249 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.260427478737382 Inf 0.175506184596404 63 299 False False 0 0 0 0 0 0 0 Inf 0.260427478737382 Inf 0.00221975582685904 0.000268935866794296 0.0079953061571445 1 0.997050890854678 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI AwRI by relaxed thresholds (not endorsed) no E, O 5 +Bedaquiline Rv0678 p.Val120Met Rv0678_p.Val120Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 603 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 205 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 5 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Val20Ala Rv0678_p.Val20Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Val20Gly Rv0678_p.Val20Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 1034 12950 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999922785885259 0.999569866411227 0.99999804510978 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 12.5241779497098 0.159396979672639 974.620016429296 0.142533667024192 158.5 1032 False False 12.5241779497098 0.159396979672639 974.620016429296 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 900 1248 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 0.99919935948759 0.995547271980628 0.999979729742686 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.38666666666666 0.0176530068458996 108.845447474822 1 167 299 False False 0 0 0 0 0 0 0 1.38666666666666 0.0176530068458996 108.845447474822 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 0.99919935948759 0.995547271980628 0.999979729742686 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv0678 p.Val7del Rv0678_p.Val7del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv0678 p.Val7fs Rv0678_p.Val7fs 1 frameshift (see "Genomic_coordinates" sheet) 1 14 11 3 11 3 1024 12948 0.0106280193236714 0.00531707433425849 0.0189367299858332 0.999768357655779 0.999323193486146 0.999952227231941 0.785714285714285 0.492024322951528 0.953420712110132 0.785714285714285 0.492024322951528 0.953420712110132 0.785714285714285 0.492024322951528 0.953420712110132 46.36328125 12.2111752799352 258.144934643206 1.0252269670794e-10 10 1032 True False 46.36328125 12.2111752799352 258.144934643206 0.0106280193236714 0.00531707433425849 0.0189367299858332 0.999768357655779 0.999323193486146 0.999952227231941 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance 1 12 10 2 10 2 891 1247 0.0110987791342952 0.00533477009732139 0.0203160650401229 0.99839871897518 0.994227708034801 0.999806018576913 0.833333333333333 0.515862251314033 0.979137474539907 0.833333333333333 0.515862251314033 0.979137474539907 0.833333333333333 0.515862251314033 0.979137474539907 6.99775533108866 1.48484358070753 65.8620363239856 0.00559299046934273 20 299 False False 0 0 0 0 0 0 0 6.99775533108866 1.48484358070753 65.8620363239856 0.0110987791342952 0.00533477009732139 0.0203160650401229 0.99839871897518 0.994227708034801 0.999806018576913 4 Evidence from ALL dataset only 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 UP from Uncertain to AwRI AwRI by relaxed thresholds (not endorsed) no ALL only E, O 4 +Bedaquiline Rv0678 p.Val85Ala Rv0678_p.Val85Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.1006C>T Rv1979c_c.1006C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 3 1033 12948 0.00193236714975845 0.000234104356582827 0.00696277826632085 0.999768357655779 0.999323193486146 0.999952227231941 0.4 0.0527449505263169 0.853367200365326 NA NA NA NA NA NA NA NA NA NA NA NA False False 8.35624394966118 0.69696757697323 73.0040625445438 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf NA NA NA NA NA NA 18 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.1035A>G Rv1979c_c.1035A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 27 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.1041C>T Rv1979c_c.1041C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.-106C>T Rv1979c_c.-106C>T 2 upstream_gene_variant 2223270 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 795 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c c.-107G>A Rv1979c_c.-107G>A 2 upstream_gene_variant 2223271 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 810 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.-10C>T Rv1979c_c.-10C>T 2 upstream_gene_variant 2223174 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 848 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c c.1104G>T Rv1979c_c.1104G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.-111delC Rv1979c_c.-111delC 2 upstream_gene_variant 2223274 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 730 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.1122G>A Rv1979c_c.1122G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.1140C>T Rv1979c_c.1140C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.-114G>A Rv1979c_c.-114G>A 2 upstream_gene_variant 2223278 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 752 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c c.1176T>G Rv1979c_c.1176T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.-120C>T Rv1979c_c.-120C>T 2 upstream_gene_variant 2223284 1 0 0 0 0 5 1035 12946 0 0 0.00355779074923997 0.999613929426299 0.999099271995683 0.999874632432309 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 796 1032 False False 0 0 13.6669955985752 0 0 0.00355779074923997 0.999613929426299 0.999099271995683 0.999874632432309 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 20 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.-123G>T Rv1979c_c.-123G>T 2 upstream_gene_variant 2223287 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 787 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.1254G>A Rv1979c_c.1254G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 30.2740898875531 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.1254G>T Rv1979c_c.1254G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.-125G>C Rv1979c_c.-125G>C 2 upstream_gene_variant 2223289 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 702 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.1282C>T Rv1979c_c.1282C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.1296C>T Rv1979c_c.1296C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.-129A>G Rv1979c_c.-129A>G 2 upstream_gene_variant 2223293 NA 0 0 0 1027 12737 8 214 0.992270531400966 0.984826941827444 0.996657229236997 0.0165238205543973 0.0143988763590045 0.018869827259627 0.0746149375181633 0.0702790288224216 0.079131683774691 NA NA NA 0 0 0.000289577241152939 NA NA NA NA NA NA False True 2.15688545183324 1.07079386455606 5.07524468370139 0 0 0.369416647552819 0.0165238205543973 0.0143988763590045 0.018869827259627 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 893 1238 8 11 0.991120976692563 0.98258009228617 0.996159096880098 0.0088070456365092 0.00440440885570809 0.0157034834929183 0.419052088221492 0.397992198014226 0.440334961584207 NA NA NA 0 0 0.00297527384131232 NA NA NA NA NA NA False True 0 0 1 0 0 1 1 0.991821486268174 0.361674119218824 2.85299776053114 0 0 0.369416647552819 0.0088070456365092 0.00440440885570809 0.0157034834929183 37706 Not assoc w R Literature evidence (PMID 28031270; 34503982) 4) Not assoc w R - Interim DOWN from NotAwR to NotAwRI yes Lit. (PMID 28031270; 34503982) 3 +Bedaquiline Rv1979c c.-13_-12insC Rv1979c_c.-13_-12insC 2 upstream_gene_variant 2223176 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 788 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.1302C>T Rv1979c_c.1302C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.-130A>C Rv1979c_c.-130A>C 2 upstream_gene_variant 2223294 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 762 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.1317A>G Rv1979c_c.1317A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 1035 12947 0 0 0.00355779074923997 0.999691143541039 0.99920939533685 0.999915840803364 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 18.9615575493326 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.1320G>A Rv1979c_c.1320G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.1329T>G Rv1979c_c.1329T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.-133G>C Rv1979c_c.-133G>C 2 upstream_gene_variant 2223297 1 0 0 0 0 6 1035 12945 0 0 0.00355779074923997 0.999536715311559 0.998991899081557 0.999829964314549 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 776 1032 False False 0 0 10.6366244843314 0 0 0.00355779074923997 0.999536715311559 0.998991899081557 0.999829964314549 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 252 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 2 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.1350T>G Rv1979c_c.1350T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.1440T>G Rv1979c_c.1440T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 3 1034 12948 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999768357655779 0.999323193486146 0.999952227231941 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 4.17408123791102 0.0794342529077097 52.0327209025694 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf NA NA NA NA NA NA 11 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.1443C>T Rv1979c_c.1443C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 12 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.-154A>G Rv1979c_c.-154A>G 2 upstream_gene_variant 2223318 1 0 0 0 0 12 1035 12939 0 0 0.00355779074923997 0.999073430623118 0.998382029737665 0.999521139337223 0 0 0.264648469397051 NA NA NA 0 0 0.264648469397051 NA NA NA NA 710 1032 False False 0 0 4.50641642099957 0 0 0.00355779074923997 0.999073430623118 0.998382029737665 0.999521139337223 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 43 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.165C>T Rv1979c_c.165C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.-168A>C Rv1979c_c.-168A>C 2 upstream_gene_variant 2223332 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 832 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.-168A>G Rv1979c_c.-168A>G 2 upstream_gene_variant 2223332 1 0 0 0 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 753 1032 False False 0 0 30.2740898875531 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.-16A>C Rv1979c_c.-16A>C 2 upstream_gene_variant 2223180 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 703 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.180C>A Rv1979c_c.180C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.183G>A Rv1979c_c.183G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.-186T>G Rv1979c_c.-186T>G 2 upstream_gene_variant 2223350 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 738 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c c.-18C>T Rv1979c_c.-18C>T 2 upstream_gene_variant 2223182 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 754 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.18G>A Rv1979c_c.18G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.-191_-187delGATGC Rv1979c_c.-191_-187delGATGC 2 upstream_gene_variant 2223350 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 731 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 242 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c c.192C>T Rv1979c_c.192C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.-19G>A Rv1979c_c.-19G>A 2 upstream_gene_variant 2223183 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 717 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.1G>C Rv1979c_c.1G>C 2 initiator_codon_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.-208C>G Rv1979c_c.-208C>G 2 upstream_gene_variant 2223372 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 683 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 194 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.-210C>T Rv1979c_c.-210C>T 2 upstream_gene_variant 2223374 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 704 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.-214G>A Rv1979c_c.-214G>A 2 upstream_gene_variant 2223378 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 0 0 0.975 0 0 0.975 0 0 54.0184755945099 1 186 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 2 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c c.-218A>G Rv1979c_c.-218A>G 2 upstream_gene_variant 2223382 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 694 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 235 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.-221G>A Rv1979c_c.-221G>A 2 upstream_gene_variant 2223385 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 824 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c c.-234_-217delCCGGCCCAACCCAGGTAT Rv1979c_c.-234_-217delCCGGCCCAACCCAGGTAT 2 upstream_gene_variant 2223380 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 797 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.234C>G Rv1979c_c.234C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.-235G>T Rv1979c_c.-235G>T 2 upstream_gene_variant 2223399 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 798 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c c.-236A>C Rv1979c_c.-236A>C 2 upstream_gene_variant 2223400 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 799 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.240C>T Rv1979c_c.240C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.320847254634342 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.-241G>A Rv1979c_c.-241G>A 2 upstream_gene_variant 2223405 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 811 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.-248G>A Rv1979c_c.-248G>A 2 upstream_gene_variant 2223412 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 829 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c c.249G>A Rv1979c_c.249G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 1034 12950 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999922785885259 0.999569866411227 0.99999804510978 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 12.5241779497098 0.159396979672639 974.620016429296 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf NA NA NA NA NA NA 17 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.-250T>G Rv1979c_c.-250T>G 2 upstream_gene_variant 2223414 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 781 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.-253dupG Rv1979c_c.-253dupG 2 upstream_gene_variant 2223416 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 732 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.-258C>A Rv1979c_c.-258C>A 2 upstream_gene_variant 2223422 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 711 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c c.-258C>T Rv1979c_c.-258C>T 2 upstream_gene_variant 2223422 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 766 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.-265T>C Rv1979c_c.-265T>C 2 upstream_gene_variant 2223429 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 771 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c c.-265T>G Rv1979c_c.-265T>G 2 upstream_gene_variant 2223429 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 844 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.-26A>C Rv1979c_c.-26A>C 2 upstream_gene_variant 2223190 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 718 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.-273T>G Rv1979c_c.-273T>G 2 upstream_gene_variant 2223437 NA 0 0 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 767 1032 False False Inf 0.320847254634342 Inf 0 0 0.00356122541865182 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 250 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0 0 0.00409036651757122 1 0.997050890854678 1 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c c.-275G>A Rv1979c_c.-275G>A 2 upstream_gene_variant 2223439 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 712 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.-277G>T Rv1979c_c.-277G>T 2 upstream_gene_variant 2223441 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 684 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.-279G>A Rv1979c_c.-279G>A 2 upstream_gene_variant 2223443 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 723 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.-280G>A Rv1979c_c.-280G>A 2 upstream_gene_variant 2223444 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 696 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 28 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.-281C>A Rv1979c_c.-281C>A 2 upstream_gene_variant 2223445 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 782 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 112 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c c.-281C>T Rv1979c_c.-281C>T 2 upstream_gene_variant 2223445 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 789 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c c.285T>A Rv1979c_c.285T>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.291C>G Rv1979c_c.291C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.-291T>C Rv1979c_c.-291T>C 2 upstream_gene_variant 2223455 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 747 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.-299C>T Rv1979c_c.-299C>T 2 upstream_gene_variant 2223463 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.306G>A Rv1979c_c.306G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.312C>T Rv1979c_c.312C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.-315C>T Rv1979c_c.-315C>T 2 upstream_gene_variant 2223479 1 0 0 0 0 4 1035 12947 0 0 0.00355779074923997 0.999691143541039 0.99920939533685 0.999915840803364 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 800 1032 False False 0 0 18.9615575493326 0 0 0.00355779074923997 0.999691143541039 0.99920939533685 0.999915840803364 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.-322T>C Rv1979c_c.-322T>C 2 upstream_gene_variant 2223486 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 772 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c c.-327C>A Rv1979c_c.-327C>A 2 upstream_gene_variant 2223491 1 35 0 35 0 36 1035 12915 0 0 0.00355779074923997 0.997220291869353 0.996153768992115 0.998052390332983 0 0 0.0973937559144919 0 0 0.100032435572105 0 0 0.0973937559144919 0 0 1.38956659255304 0.109002996734169 151 1032 False False 0 0 1.34896709814095 0 0 0.00355779074923997 0.997220291869353 0.996153768992115 0.998052390332983 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 12 0 12 0 12 901 1237 0 0 0.0040858359972341 0.99039231385108 0.983277503936433 0.995025993852145 0 0 0.264648469397051 0 0 0.264648469397051 0 0 0.264648469397051 0 0 0.495897417581732 0.00194632643849164 14 299 True False 0 0 0 0 0 0 0 0 0 0.495897417581732 0 0 0.0040858359972341 0.99039231385108 0.983277503936433 0.995025993852145 174 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.-328G>C Rv1979c_c.-328G>C 2 upstream_gene_variant 2223492 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c c.-328G>T Rv1979c_c.-328G>T 2 upstream_gene_variant 2223492 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 777 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.-345T>C Rv1979c_c.-345T>C 2 upstream_gene_variant 2223509 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 819 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.-356C>G Rv1979c_c.-356C>G 2 upstream_gene_variant 2223520 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 748 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.-361_-353delCAGACCGGAinsT Rv1979c_c.-361_-353delCAGACCGGAinsT 2 upstream_gene_variant 2223517 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 830 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.-368G>A Rv1979c_c.-368G>A 2 upstream_gene_variant 2223532 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 713 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 237 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c c.369C>G Rv1979c_c.369C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 54.0184755945099 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.-378A>G Rv1979c_c.-378A>G 2 upstream_gene_variant 2223542 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 825 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.-386C>T Rv1979c_c.-386C>T 2 upstream_gene_variant 2223550 1 0 0 0 0 11 1035 12940 0 0 0.00355779074923997 0.999150644737858 0.998480778201554 0.999575931082308 0 0 0.284914152918154 NA NA NA 0 0 0.284914152918154 NA NA NA NA 697 1032 False False 0 0 4.98927284838772 0 0 0.00355779074923997 0.999150644737858 0.998480778201554 0.999575931082308 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 37 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.387C>T Rv1979c_c.387C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.-389C>A Rv1979c_c.-389C>A 2 upstream_gene_variant 2223553 0 0 0 0 64 156 971 12795 0.0618357487922705 0.0479431536767396 0.0782802438754997 0.987954598100532 0.985923540758158 0.989761707398276 0.29090909090909 0.231808844242587 0.355742902469658 NA NA NA 0 0 0.0233692715913802 NA NA NA NA 675 1032 False False 5.40600491166917 3.94556191264766 7.33172820082218 0 0 0.00379184469289869 0.987954598100532 0.985923540758158 0.989761707398276 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 61 19 840 1230 0.0677025527192008 0.0521793618233623 0.0861205038189398 0.984787830264211 0.976345865372128 0.990817086894646 0.7625 0.654223028859731 0.850546248143359 NA NA NA 0 0 0.176466911806965 NA NA NA NA 232 299 False False 0 0 0 0 0 0 0 4.70112781954887 2.74450329860081 8.39127554887652 0 0 0.00438189452178057 0.984787830264211 0.976345865372128 0.990817086894646 672 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.-393T>C Rv1979c_c.-393T>C 2 upstream_gene_variant 2223557 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 801 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 256 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 14 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c c.-398A>G Rv1979c_c.-398A>G 2 upstream_gene_variant 2223562 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 749 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.-402T>C Rv1979c_c.-402T>C 2 upstream_gene_variant 2223566 1 0 0 0 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 741 1032 False False 0 0 30.2740898875531 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.408G>A Rv1979c_c.408G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 54.0184755945099 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.-411C>G Rv1979c_c.-411C>G 2 upstream_gene_variant 2223575 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 742 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.-426T>G Rv1979c_c.-426T>G 2 upstream_gene_variant 2223590 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 849 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.-429C>T Rv1979c_c.-429C>T 2 upstream_gene_variant 2223593 1 0 0 0 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 681 1032 False False 0 0 30.2740898875531 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.42G>A Rv1979c_c.42G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 27 1035 12924 0 0 0.00355779074923997 0.997915218902015 0.996968191678099 0.998625680487827 0 0 0.127702867615432 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.83138346338155 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 76 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.42G>C Rv1979c_c.42G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.-440C>T Rv1979c_c.-440C>T 2 upstream_gene_variant 2223604 1 3 0 3 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 30.2740898875531 1 426 1032 False False 0 0 30.2740898875531 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.-447A>C Rv1979c_c.-447A>C 2 upstream_gene_variant 2223611 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 833 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.-44T>G Rv1979c_c.-44T>G 2 upstream_gene_variant 2223208 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 812 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.-452T>C Rv1979c_c.-452T>C 2 upstream_gene_variant 2223616 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 813 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.-458G>A Rv1979c_c.-458G>A 2 upstream_gene_variant 2223622 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 755 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.-461C>A Rv1979c_c.-461C>A 2 upstream_gene_variant 2223625 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 820 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c c.465C>T Rv1979c_c.465C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.320847254634342 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.-50A>C Rv1979c_c.-50A>C 2 upstream_gene_variant 2223214 1 54 0 54 0 74 1035 12877 0 0 0.00355779074923997 0.994286155509227 0.992832030325952 0.995510818446606 0 0 0.0486276162379895 0 0 0.0660315142444217 0 0 0.0486276162379895 0 0 0.881280683555157 0.0323552705264275 90 1032 False False 0 0 0.637155399052547 0 0 0.00355779074923997 0.994286155509227 0.992832030325952 0.995510818446606 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 901 1245 0 0 0.0040858359972341 0.99679743795036 0.991820638117455 0.999126741506926 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.35112512116886 0.269214471587408 79.5 299 False False 0 0 0 0 0 0 0 0 0 2.09854624946918 0 0 0.0040858359972341 0.99679743795036 0.991820638117455 0.999126741506926 131 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.546G>T Rv1979c_c.546G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 54.0184755945099 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.561C>T Rv1979c_c.561C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 30.2740898875531 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.594G>A Rv1979c_c.594G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.-59A>G Rv1979c_c.-59A>G 2 upstream_gene_variant 2223223 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 705 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.612G>T Rv1979c_c.612G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.660T>C Rv1979c_c.660T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 54.0184755945099 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.681C>A Rv1979c_c.681C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.-68A>G Rv1979c_c.-68A>G 2 upstream_gene_variant 2223232 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 688 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c c.-69G>C Rv1979c_c.-69G>C 2 upstream_gene_variant 2223233 1 0 0 0 0 7 1035 12944 0 0 0.00355779074923997 0.999459501196818 0.998886684999561 0.999782664716124 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 826 1032 False False 0 0 8.6896253144418 0 0 0.00355779074923997 0.999459501196818 0.998886684999561 0.999782664716124 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 901 1247 0 0 0.0040858359972341 0.99839871897518 0.994227708034801 0.999806018576913 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 267 299 False False 0 0 0 0 0 0 0 0 0 7.38115169544997 0 0 0.0040858359972341 0.99839871897518 0.994227708034801 0.999806018576913 60 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.6C>T Rv1979c_c.6C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 30.2740898875531 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.702T>C Rv1979c_c.702T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.-70G>A Rv1979c_c.-70G>A 2 upstream_gene_variant 2223234 1 0 0 0 0 7 1035 12944 0 0 0.00355779074923997 0.999459501196818 0.998886684999561 0.999782664716124 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 685 1032 False False 0 0 8.6896253144418 0 0 0.00355779074923997 0.999459501196818 0.998886684999561 0.999782664716124 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c c.741G>T Rv1979c_c.741G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.750G>A Rv1979c_c.750G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.754C>T Rv1979c_c.754C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 54.0184755945099 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.777G>A Rv1979c_c.777G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.-78_-67delACAGGCCGGGAG Rv1979c_c.-78_-67delACAGGCCGGGAG 2 upstream_gene_variant 2223230 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 763 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c c.780C>T Rv1979c_c.780C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.802T>C Rv1979c_c.802T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.84C>T Rv1979c_c.84C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 66.6031790373652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.867G>C Rv1979c_c.867G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.882C>G Rv1979c_c.882C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.93T>C Rv1979c_c.93T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 484.323232748194 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Bedaquiline Rv1979c c.-96C>T Rv1979c_c.-96C>T 2 upstream_gene_variant 2223260 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 733 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c deletion Rv1979c_deletion 2 feature_ablation (see "Genomic_coordinates" sheet) NA 0 0 0 1 9 1034 12942 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999305072967338 0.998681223764717 0.999682187439592 0.1 0.00252857854446178 0.445016117028195 NA NA NA 0 0 0.336267116879942 NA NA NA NA 706 1032 False False 1.39071566731141 0.0316987299084449 10.0539439880658 0 0 0.00356122541865182 0.999305072967338 0.998681223764717 0.999682187439592 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 89 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c LoF Rv1979c_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 1 0 1 3 68 1032 12883 0.00289855072463768 0.000598150191171612 0.00844722324607505 0.994749440197668 0.993348346731217 0.995920496507883 0.0422535211267605 0.00879991956156422 0.118555094452998 0 0 0.975 0 0 0.0528030427936397 0 0 483.226636724418 1 426 1032 False False 0.550743844049247 0.110625881848442 1.68376830965531 0 0 0.00356811469079427 0.994749440197668 0.993348346731217 0.995920496507883 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 9 899 1240 0.00221975582685904 0.000268935866794296 0.0079953061571445 0.99279423538831 0.986365463514992 0.9966999266574 0.181818181818181 0.0228311982999596 0.517755852360172 NA NA NA 0 0 0.336267116879942 NA NA NA NA 299 299 False False 0 0 0 0 0 0 0 0.306513409961685 0.0321652306629787 1.48653091297236 0 0 0.00409490709625158 0.99279423538831 0.986365463514992 0.9966999266574 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c p.Ala105Asp Rv1979c_p.Ala105Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 714 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Ala105Thr Rv1979c_p.Ala105Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 6 1035 12945 0 0 0.00355779074923997 0.999536715311559 0.998991899081557 0.999829964314549 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 756 1032 False False 0 0 10.6366244843314 0 0 0.00355779074923997 0.999536715311559 0.998991899081557 0.999829964314549 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 16 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Ala10Val Rv1979c_p.Ala10Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 5 1035 12946 0 0 0.00355779074923997 0.999613929426299 0.999099271995683 0.999874632432309 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 778 1032 False False 0 0 13.6669955985752 0 0 0.00355779074923997 0.999613929426299 0.999099271995683 0.999874632432309 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 901 1247 0 0 0.0040858359972341 0.99839871897518 0.994227708034801 0.999806018576913 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 253 299 False False 0 0 0 0 0 0 0 0 0 7.38115169544997 0 0 0.0040858359972341 0.99839871897518 0.994227708034801 0.999806018576913 10 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Ala121Val Rv1979c_p.Ala121Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 689 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c p.Ala126Thr Rv1979c_p.Ala126Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 676 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Ala158Thr Rv1979c_p.Ala158Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 790 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Ala199Gly Rv1979c_p.Ala199Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 802 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 257 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c p.Ala202Ser Rv1979c_p.Ala202Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 783 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Ala222Thr Rv1979c_p.Ala222Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 31 1035 12920 0 0 0.00355779074923997 0.997606362443054 0.99660412843394 0.998373077787307 0 0 0.11218874692237 NA NA NA 0 0 0.11218874692237 NA NA NA NA 784 1032 False False 0 0 1.58035830287515 0 0 0.00355779074923997 0.997606362443054 0.99660412843394 0.998373077787307 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 28 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Ala247Thr Rv1979c_p.Ala247Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 827 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Ala247Val Rv1979c_p.Ala247Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 814 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 262 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 6 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c p.Ala259Glu Rv1979c_p.Ala259Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 834 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Ala259Thr Rv1979c_p.Ala259Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 803 1032 False False 0 0 30.2740898875531 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 901 1246 0 0 0.0040858359972341 0.99759807846277 0.992996755835892 0.999504391864096 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 258 299 False False 0 0 0 0 0 0 0 0 0 3.35381326044578 0 0 0.0040858359972341 0.99759807846277 0.992996755835892 0.999504391864096 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c p.Ala298Ser Rv1979c_p.Ala298Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 484.286119137424 1 426 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Ala331Val Rv1979c_p.Ala331Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 806 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Ala357Val Rv1979c_p.Ala357Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 743 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c p.Ala378Thr Rv1979c_p.Ala378Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 677 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Ala401Thr Rv1979c_p.Ala401Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 724 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c p.Ala405Pro Rv1979c_p.Ala405Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 850 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Ala406Thr Rv1979c_p.Ala406Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 845 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c p.Ala429fs Rv1979c_p.Ala429fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 835 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Ala461Glu Rv1979c_p.Ala461Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 6 1035 12945 0 0 0.00355779074923997 0.999536715311559 0.998991899081557 0.999829964314549 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 725 1032 False False 0 0 10.6366244843314 0 0 0.00355779074923997 0.999536715311559 0.998991899081557 0.999829964314549 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c p.Ala47Thr Rv1979c_p.Ala47Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 690 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Ala66Ser Rv1979c_p.Ala66Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 804 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Ala66Val Rv1979c_p.Ala66Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 821 1032 False False Inf 0.320847254634342 Inf 0 0 0.00356122541865182 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 265 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0 0 0.00409036651757122 1 0.997050890854678 1 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c p.Ala84Thr Rv1979c_p.Ala84Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 739 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Ala85Gly Rv1979c_p.Ala85Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 707 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c p.Ala85Thr Rv1979c_p.Ala85Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 836 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c p.Arg409Gln Rv1979c_p.Arg409Gln 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 263 227 772 12724 0.254106280193236 0.22783024196526 0.281788501924115 0.98247239595398 0.980062198174855 0.984662130880106 0.536734693877551 0.491454544644001 0.581569063543049 NA NA NA 0 0 0.0161192421133921 NA NA NA NA 851 1032 False False 19.0957293830316 15.6815515569593 23.2229235138293 0 0 0.00476694315111282 0.98247239595398 0.980062198174855 0.984662130880106 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 241 8 660 1241 0.267480577136514 0.238822108840775 0.297668094518708 0.99359487590072 0.98741855030806 0.99723078615598 0.967871485943775 0.937677922669268 0.986029100796818 NA NA NA 0 0 0.369416647552819 NA NA NA NA 271 299 False False 0 0 0 0 0 0 0 56.6441287878787 28.0147176048919 133.416923081696 0 0 0.00557362071254224 0.99359487590072 0.98741855030806 0.99723078615598 230 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Arg441Trp Rv1979c_p.Arg441Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c p.Arg473dup Rv1979c_p.Arg473dup 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 115 0 115 0 117 1035 12834 0 0 0.00355779074923997 0.990965948575399 0.989182648633397 0.992523028529371 0 0 0.0310370316931115 0 0 0.0315681959882471 0 0 0.0310370316931115 0 0 0.404986156723497 0.000234390675506228 33 1032 True False 0 0 0.39795605455275 0 0 0.00355779074923997 0.990965948575399 0.989182648633397 0.992523028529371 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 901 1245 0 0 0.0040858359972341 0.99679743795036 0.991820638117455 0.999126741506926 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.09854624946918 0.144386210855025 47 299 False False 0 0 0 0 0 0 0 0 0 2.09854624946918 0 0 0.0040858359972341 0.99679743795036 0.991820638117455 0.999126741506926 362 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Arg7Lys Rv1979c_p.Arg7Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 901 1247 0 0 0.0040858359972341 0.99839871897518 0.994227708034801 0.999806018576913 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.38115169544997 0.512872834309089 156.5 299 False False 0 0 0 0 0 0 0 0 0 7.38115169544997 0 0 0.0040858359972341 0.99839871897518 0.994227708034801 0.999806018576913 9 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c p.Arg7Ser Rv1979c_p.Arg7Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 29 1035 12922 0 0 0.00355779074923997 0.997760790672535 0.996785692633168 0.998499869321082 0 0 0.119444869069502 NA NA NA 0 0 0.119444869069502 NA NA NA NA 779 1032 False False 0 0 1.69663891236676 0 0 0.00355779074923997 0.997760790672535 0.996785692633168 0.998499869321082 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 59 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Arg88fs Rv1979c_p.Arg88fs 2 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 715 1032 False False Inf 0.320847254634342 Inf 0 0 0.00356122541865182 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 238 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0 0 0.00409036651757122 1 0.997050890854678 1 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c p.Arg88His Rv1979c_p.Arg88His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 686 1032 False False 0 0 30.2740898875531 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Arg88Leu Rv1979c_p.Arg88Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 695 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Asn240fs Rv1979c_p.Asn240fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 822 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Asn297Ser Rv1979c_p.Asn297Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 791 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Asp129fs Rv1979c_p.Asp129fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 726 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Asp249Glu Rv1979c_p.Asp249Glu 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 6 1031 12945 0.0038647342995169 0.00105398325986622 0.009865452176262 0.999536715311559 0.998991899081557 0.999829964314549 0.4 0.121552258119827 0.737621923393055 NA NA NA 0 0 0.4592581264399 NA NA NA NA 744 1032 False False 8.37051406401551 1.73393047340217 35.3590922440127 0 0 0.00357156933212359 0.999536715311559 0.998991899081557 0.999829964314549 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 1 899 1248 0.00221975582685904 0.000268935866794296 0.0079953061571445 0.99919935948759 0.995547271980628 0.999979729742686 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 245 299 False False 0 0 0 0 0 0 0 2.77641824249165 0.144259516740608 163.770215780116 0 0 0.00409490709625158 0.99919935948759 0.995547271980628 0.999979729742686 31 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Asp286Gly Rv1979c_p.Asp286Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 75 771 960 12180 0.072463768115942 0.0574206760212043 0.0899897718426074 0.940467917535325 0.936254182620124 0.944482339698117 0.0886524822695035 0.0703679363345309 0.109859669887744 NA NA NA 0 0 0.00477311117762926 NA NA NA NA NA NA False True 1.23419260700389 0.951732080850316 1.58150156878292 0 0 0.00383520949071212 0.940467917535325 0.936254182620124 0.944482339698117 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 71 48 830 1201 0.0788013318534961 0.0620546802248006 0.0983605924943028 0.961569255404323 0.949367090556078 0.971530769247181 0.596638655462184 0.502805036630988 0.685543828502989 NA NA NA 0 0 0.0739727853472802 NA NA NA NA NA NA False True 0 0 1 0 0 0 1 2.14033634538152 1.44601465779024 3.18909428145964 0 0 0.00443457120011716 0.961569255404323 0.949367090556078 0.971530769247181 4012 Literature evidence (PMID 28031270; 34503982) 4) Not assoc w R - Interim UP from Uncertain to NotAwRI yes Lit. (PMID 28031270; 34503982) 4 +Bedaquiline Rv1979c p.Asp347Gly Rv1979c_p.Asp347Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 839 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Gln188fs Rv1979c_p.Gln188fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 740 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Gln385* Rv1979c_p.Gln385* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 805 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Glu38Asp Rv1979c_p.Glu38Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 53 96 982 12855 0.051207729468599 0.038590043542881 0.0664488943753333 0.992587444984943 0.990955431041568 0.993991800985073 0.355704697986577 0.279069335144419 0.438204134244061 0 0 0.975 0 0 0.0376969216235875 0 0 506.541206832652 1 426 1032 False False 7.22711939918533 5.03289882495156 10.2758121628813 0 0 0.00374944958308598 0.992587444984943 0.990955431041568 0.993991800985073 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 51 7 850 1242 0.0566037735849056 0.0424320509112395 0.0737551761942074 0.99439551641313 0.988486910078977 0.99774382672033 0.879310344827586 0.767016362292006 0.950073383976519 NA NA NA 0 0 0.409616397225003 NA NA NA NA 266 299 False False 0 0 0 0 0 0 0 10.6457142857142 4.77513852549432 27.9254717592371 0 0 0.00433045460510758 0.99439551641313 0.988486910078977 0.99774382672033 108 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Glu38Lys Rv1979c_p.Glu38Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 4 1035 12947 0 0 0.00355779074923997 0.999691143541039 0.99920939533685 0.999915840803364 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 484.211891785767 1 426 1032 False False 0 0 18.9615575493326 0 0 0.00355779074923997 0.999691143541039 0.99920939533685 0.999915840803364 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 17 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Glu403Gly Rv1979c_p.Glu403Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 6 1035 12945 0 0 0.00355779074923997 0.999536715311559 0.998991899081557 0.999829964314549 0 0 0.4592581264399 0 0 0.975 0 0 0.4592581264399 0 0 484.137664260618 1 426 1032 False False 0 0 10.6366244843314 0 0 0.00355779074923997 0.999536715311559 0.998991899081557 0.999829964314549 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Gly107Ala Rv1979c_p.Gly107Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 678 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c p.Gly181_Ile185del Rv1979c_p.Gly181_Ile185del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 773 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c p.Gly181Glu Rv1979c_p.Gly181Glu 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 815 1032 False False Inf 0.320847254634342 Inf 0 0 0.00356122541865182 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 263 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0 0 0.00409036651757122 1 0.997050890854678 1 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c p.Gly214Ser Rv1979c_p.Gly214Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c p.Gly216Asp Rv1979c_p.Gly216Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 698 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Gly334Glu Rv1979c_p.Gly334Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 852 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c p.His12Tyr Rv1979c_p.His12Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 840 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.His404Tyr Rv1979c_p.His404Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.His98Tyr Rv1979c_p.His98Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 719 1032 False False 0 0 30.2740898875531 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 240 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 4 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Ile100del Rv1979c_p.Ile100del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 679 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Ile104Thr Rv1979c_p.Ile104Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 32 1034 12919 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.997529148328314 0.996513669257383 0.998309344219965 0.0303030303030303 0.000766912075048109 0.157593972272496 NA NA NA 0 0 0.108881160679352 NA NA NA NA 734 1032 False False 0.390443665377176 0.00958315100942399 2.34256617189266 0 0 0.00356122541865182 0.997529148328314 0.996513669257383 0.998309344219965 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 6 900 1243 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 0.99519615692554 0.989573581557686 0.998235095604207 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA 0 0 0.4592581264399 NA NA NA NA 243 299 False False 0 0 0 0 0 0 0 0.230185185185185 0.00500317111347075 1.90331136461667 0 0 0.00409036651757122 0.99519615692554 0.989573581557686 0.998235095604207 120 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Ile226Thr Rv1979c_p.Ile226Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 768 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Ile238Thr Rv1979c_p.Ile238Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 816 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Ile256Thr Rv1979c_p.Ile256Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 792 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 255 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 24 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Ile304_Ala381del Rv1979c_p.Ile304_Ala381del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 708 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c p.Ile394Thr Rv1979c_p.Ile394Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 699 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Ile394Val Rv1979c_p.Ile394Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 720 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c p.Leu14Arg Rv1979c_p.Leu14Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 745 1032 False False 0 0 30.2740898875531 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c p.Leu174Phe Rv1979c_p.Leu174Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 10 1035 12941 0 0 0.00355779074923997 0.999227858852598 0.998580464895556 0.999629668183042 0 0 0.30849710781876 NA NA NA 0 0 0.30849710781876 NA NA NA NA 757 1032 False False 0 0 5.58682568371909 0 0 0.00355779074923997 0.999227858852598 0.998580464895556 0.999629668183042 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 901 1246 0 0 0.0040858359972341 0.99759807846277 0.992996755835892 0.999504391864096 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 247 299 False False 0 0 0 0 0 0 0 0 0 3.35381326044578 0 0 0.0040858359972341 0.99759807846277 0.992996755835892 0.999504391864096 18 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Leu229del Rv1979c_p.Leu229del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 0 0 0 0 6 1035 12945 0 0 0.00355779074923997 0.999536715311559 0.998991899081557 0.999829964314549 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 846 1032 False False 0 0 10.6366244843314 0 0 0.00355779074923997 0.999536715311559 0.998991899081557 0.999829964314549 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 901 1247 0 0 0.0040858359972341 0.99839871897518 0.994227708034801 0.999806018576913 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 270 299 False False 0 0 0 0 0 0 0 0 0 7.38115169544997 0 0 0.0040858359972341 0.99839871897518 0.994227708034801 0.999806018576913 3 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Leu229Ser Rv1979c_p.Leu229Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 841 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Leu330Val Rv1979c_p.Leu330Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 793 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Leu419Val Rv1979c_p.Leu419Val 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 853 1032 False False Inf 0.320847254634342 Inf 0 0 0.00356122541865182 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 272 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0 0 0.00409036651757122 1 0.997050890854678 1 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c p.Lys13Gln Rv1979c_p.Lys13Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c p.Met1? Rv1979c_p.Met1? 2 start_lost (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 728 1032 False False 0 0 30.2740898875531 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 241 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Met245Leu Rv1979c_p.Met245Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 735 1032 False False Inf 0.320847254634342 Inf 0 0 0.00356122541865182 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 244 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0 0 0.00409036651757122 1 0.997050890854678 1 6 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c p.Met275Thr Rv1979c_p.Met275Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 854 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Met49Ile Rv1979c_p.Met49Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 785 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c p.Phe113fs Rv1979c_p.Phe113fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c p.Phe122Leu Rv1979c_p.Phe122Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 700 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Phe144Cys Rv1979c_p.Phe144Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c p.Phe144fs Rv1979c_p.Phe144fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 1 16 1034 12935 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.998764574164157 0.99799451910523 0.999293687702942 0.0588235294117647 0.00148817439126663 0.28688939666722 NA NA NA 0 0 0.205907214207822 NA NA NA NA 817 1032 False False 0.781854448742746 0.0186264949145497 5.04240244463887 0 0 0.00356122541865182 0.998764574164157 0.99799451910523 0.999293687702942 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 2 900 1247 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 0.99839871897518 0.994227708034801 0.999806018576913 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 264 299 False False 0 0 0 0 0 0 0 0.692777777777777 0.0117351849678213 13.3292134004368 0 0 0.00409036651757122 0.99839871897518 0.994227708034801 0.999806018576913 110 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Phe154Val Rv1979c_p.Phe154Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c p.Phe172Ser Rv1979c_p.Phe172Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 1035 12948 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 750 1032 False False 0 0 30.2740898875531 0 0 0.00355779074923997 0.999768357655779 0.999323193486146 0.999952227231941 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Phe300Leu Rv1979c_p.Phe300Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 1031 12951 0.0038647342995169 0.00105398325986622 0.009865452176262 1 0.999715206999795 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 746 1032 False False Inf 8.27463359653372 Inf 0 0 0.00357156933212359 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 897 1249 0.00443951165371809 0.00121090206228936 0.0113275932937957 1 0.997050890854678 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 246 299 False False 0 0 0 0 0 0 0 Inf 0.916560415731825 Inf 0 0 0.0041040185629249 1 0.997050890854678 1 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c p.Phe300Val Rv1979c_p.Phe300Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 736 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Phe386Val Rv1979c_p.Phe386Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 786 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Phe412Cys Rv1979c_p.Phe412Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 780 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c p.Pro123Ser Rv1979c_p.Pro123Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c p.Pro36Ser Rv1979c_p.Pro36Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 691 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c p.Pro478Gln Rv1979c_p.Pro478Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 10 1034 12941 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.999227858852598 0.998580464895556 0.999629668183042 0.0909090909090909 0.00229897221381426 0.412779916988382 0 0 0.707598226178713 0 0 0.30849710781876 0 0 30.2865422845812 1 426 1032 False False 1.25154738878143 0.0288114825337458 8.81318448011735 0 0 0.00356122541865182 0.999227858852598 0.998580464895556 0.999629668183042 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 2 900 1247 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 0.99839871897518 0.994227708034801 0.999806018576913 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 234 299 False False 0 0 0 0 0 0 0 0.692777777777777 0.0117351849678213 13.3292134004368 0 0 0.00409036651757122 0.99839871897518 0.994227708034801 0.999806018576913 22 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Pro4Ala Rv1979c_p.Pro4Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 692 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Ser175Leu Rv1979c_p.Ser175Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 709 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 22 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Ser206Leu Rv1979c_p.Ser206Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 818 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Ser219Ala Rv1979c_p.Ser219Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 721 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Ser219Trp Rv1979c_p.Ser219Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 807 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 259 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c p.Ser237Leu Rv1979c_p.Ser237Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 794 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Ser262Leu Rv1979c_p.Ser262Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 1035 12947 0 0 0.00355779074923997 0.999691143541039 0.99920939533685 0.999915840803364 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 774 1032 False False 0 0 18.9615575493326 0 0 0.00355779074923997 0.999691143541039 0.99920939533685 0.999915840803364 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Ser320Leu Rv1979c_p.Ser320Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 737 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c p.Ser352fs Rv1979c_p.Ser352fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 10 1035 12941 0 0 0.00355779074923997 0.999227858852598 0.998580464895556 0.999629668183042 0 0 0.30849710781876 NA NA NA 0 0 0.30849710781876 NA NA NA NA 808 1032 False False 0 0 5.58682568371909 0 0 0.00355779074923997 0.999227858852598 0.998580464895556 0.999629668183042 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 901 1246 0 0 0.0040858359972341 0.99759807846277 0.992996755835892 0.999504391864096 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 260 299 False False 0 0 0 0 0 0 0 0 0 3.35381326044578 0 0 0.0040858359972341 0.99759807846277 0.992996755835892 0.999504391864096 76 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Ser358Leu Rv1979c_p.Ser358Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 484.286119137424 1 426 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Ser358* Rv1979c_p.Ser358* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 855 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Thr270Ala Rv1979c_p.Thr270Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 38 1035 12913 0 0 0.00355779074923997 0.997065863639873 0.99597487067054 0.997922819293648 0 0 0.0925127614158782 NA NA NA 0 0 0.0925127614158782 NA NA NA NA 701 1032 False False 0 0 1.27427839926074 0 0 0.00355779074923997 0.997065863639873 0.99597487067054 0.997922819293648 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 8 901 1241 0 0 0.0040858359972341 0.99359487590072 0.98741855030806 0.99723078615598 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 236 299 False False 0 0 0 0 0 0 0 0 0 0.809547810018533 0 0 0.0040858359972341 0.99359487590072 0.98741855030806 0.99723078615598 78 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Thr270Ile Rv1979c_p.Thr270Ile 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 1034 12951 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 1 0.999715206999795 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 764 1032 False False Inf 0.320847254634342 Inf 0 0 0.00356122541865182 1 0.999715206999795 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 249 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0 0 0.00409036651757122 1 0.997050890854678 1 6 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c p.Thr356Lys Rv1979c_p.Thr356Lys 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 9 4 1026 12947 0.00869565217391304 0.003983694112966 0.0164426238532791 0.999691143541039 0.99920939533685 0.999915840803364 0.692307692307692 0.385738338249294 0.909079605427903 NA NA NA 0 0 0.602364635616474 NA NA NA NA 758 1032 False False 28.3925438596491 7.90262443322765 126.076375520692 0 0 0.00358894337008483 0.999691143541039 0.99920939533685 0.999915840803364 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 8 0 893 1249 0.00887902330743618 0.00384090311990167 0.0174199077138292 1 0.997050890854678 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 248 299 False False 0 0 0 0 0 0 0 Inf 2.37877235677569 Inf 0 0 0.00412236368190574 1 0.997050890854678 1 26 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c p.Thr413Asn Rv1979c_p.Thr413Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 693 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c p.Thr82fs Rv1979c_p.Thr82fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 759 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c p.Thr83Ala Rv1979c_p.Thr83Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 828 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Trp106* Rv1979c_p.Trp106* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 682 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Trp197* Rv1979c_p.Trp197* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 842 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 269 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c p.Tyr230Cys Rv1979c_p.Tyr230Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 843 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c p.Tyr230* Rv1979c_p.Tyr230* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 727 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c p.Tyr434Cys Rv1979c_p.Tyr434Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 5 1035 12946 0 0 0.00355779074923997 0.999613929426299 0.999099271995683 0.999874632432309 0 0 0.521823750104981 0 0 0.975 0 0 0.521823750104981 0 0 484.174778044879 1 426 1032 False False 0 0 13.6669955985752 0 0 0.00355779074923997 0.999613929426299 0.999099271995683 0.999874632432309 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 254 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 1 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Tyr51Asn Rv1979c_p.Tyr51Asn 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 10 237 1025 12714 0.00966183574879227 0.00464267349503022 0.0176964729633415 0.981700254806578 0.979241988106854 0.983938511580846 0.0404858299595141 0.0195825130661985 0.0731927313977547 NA NA NA 0 0 0.015444385312427 NA NA NA NA 680 1032 False False 0.523371410929299 0.246992296641412 0.983783560345165 0 0 0.00359243848141287 0.981700254806578 0.979241988106854 0.983938511580846 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 10 7 891 1242 0.0110987791342952 0.00533477009732139 0.0203160650401229 0.99439551641313 0.988486910078977 0.99774382672033 0.588235294117647 0.329247153946757 0.815563038216053 NA NA NA 0 0 0.409616397225003 NA NA NA NA 233 299 False False 0 0 0 0 0 0 0 1.99134199134199 0.681017861646678 6.18706532083415 0 0 0.00413159788160957 0.99439551641313 0.988486910078977 0.99774382672033 148 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Tyr71Cys Rv1979c_p.Tyr71Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 729 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c p.Tyr79Cys Rv1979c_p.Tyr79Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 775 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Val108fs Rv1979c_p.Val108fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 12 1035 12939 0 0 0.00355779074923997 0.999073430623118 0.998382029737665 0.999521139337223 0 0 0.264648469397051 NA NA NA 0 0 0.264648469397051 NA NA NA NA 837 1032 False False 0 0 4.50641642099957 0 0 0.00355779074923997 0.999073430623118 0.998382029737665 0.999521139337223 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 268 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 17 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c p.Val114fs Rv1979c_p.Val114fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 831 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Val120Leu Rv1979c_p.Val120Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 769 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c p.Val136Leu Rv1979c_p.Val136Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 765 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Val190Ala Rv1979c_p.Val190Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 847 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Val210Phe Rv1979c_p.Val210Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 722 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Val273Ala Rv1979c_p.Val273Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 1035 12947 0 0 0.00355779074923997 0.999691143541039 0.99920939533685 0.999915840803364 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 838 1032 False False 0 0 18.9615575493326 0 0 0.00355779074923997 0.999691143541039 0.99920939533685 0.999915840803364 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Val2Ala Rv1979c_p.Val2Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 1035 12947 0 0 0.00355779074923997 0.999691143541039 0.99920939533685 0.999915840803364 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 760 1032 False False 0 0 18.9615575493326 0 0 0.00355779074923997 0.999691143541039 0.99920939533685 0.999915840803364 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Val305Asp Rv1979c_p.Val305Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 751 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c p.Val384Ile Rv1979c_p.Val384Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Val416Met Rv1979c_p.Val416Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 823 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c p.Val423Ala Rv1979c_p.Val423Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 1035 12945 0 0 0.00355779074923997 0.999536715311559 0.998991899081557 0.999829964314549 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 10.6366244843314 1 426 1032 False False 0 0 10.6366244843314 0 0 0.00355779074923997 0.999536715311559 0.998991899081557 0.999829964314549 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 0 0 0.975 0 0 0.975 0 0 54.0184755945099 1 186 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 23 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Val423Leu Rv1979c_p.Val423Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 687 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Val426Ile Rv1979c_p.Val426Ile 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 87 1034 12864 0.000966183574879227 2.44613510426406e-05 0.00537135637726426 0.993282372017604 0.991720336485028 0.9946160586711 0.0113636363636363 0.000287660981101565 0.0616937539593865 NA NA NA 0 0 0.0415145659926378 NA NA NA NA 770 1032 False False 0.143000066697792 0.0035799901883363 0.819933734016269 0 0 0.00356122541865182 0.993282372017604 0.991720336485028 0.9946160586711 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 900 1249 0.00110987791342952 2.8099281106018e-05 0.00616817842561223 1 0.997050890854678 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 251 299 False False 0 0 0 0 0 0 0 Inf 0.0355442960786845 Inf 0 0 0.00409036651757122 1 0.997050890854678 1 140 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Val458Ala Rv1979c_p.Val458Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 66.6031790373652 1 216 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c p.Val459Ile Rv1979c_p.Val459Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 0 0 0.975 0 0 0.975 0 0 484.323232748194 1 426 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Val52Gly Rv1979c_p.Val52Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 9 1035 12942 0 0 0.00355779074923997 0.999305072967338 0.998681223764717 0.999682187439592 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 809 1032 False False 0 0 6.34492522562988 0 0 0.00355779074923997 0.999305072967338 0.998681223764717 0.999682187439592 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 901 1247 0 0 0.0040858359972341 0.99839871897518 0.994227708034801 0.999806018576913 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 261 299 False False 0 0 0 0 0 0 0 0 0 7.38115169544997 0 0 0.0040858359972341 0.99839871897518 0.994227708034801 0.999806018576913 25 3) Uncertain significance No change no 1 +Bedaquiline Rv1979c p.Val96fs Rv1979c_p.Val96fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 1035 12950 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 716 1032 False False 0 0 484.323232748194 0 0 0.00355779074923997 0.999922785885259 0.999569866411227 0.99999804510978 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 901 1248 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 239 299 False False 0 0 0 0 0 0 0 0 0 54.0184755945099 0 0 0.0040858359972341 0.99919935948759 0.995547271980628 0.999979729742686 12 3) Uncertain significance New Uncertain no 0 +Bedaquiline Rv1979c p.Val96Ile Rv1979c_p.Val96Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 1035 12949 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 761 1032 False False 0 0 66.6031790373652 0 0 0.00355779074923997 0.999845571770519 0.999442264649511 0.999981297477798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin bacA c.1044G>A bacA_c.1044G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 123 905 1926 14578 0.0600292825768667 0.0501355694552957 0.0712036317462642 0.941548795453077 0.937737556398936 0.945193063277517 0.11964980544747 0.100434918771747 0.141071980200668 NA NA NA NA NA NA NA NA NA NA NA NA False True 1.02872239720486 0.840044718354437 1.25112168056595 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 103 744 1202 7898 0.0789272030651341 0.0648769207545126 0.094907003000427 0.913908817403378 0.907796582327933 0.919740273399019 0.121605667060212 0.10035187182777 0.145531496303211 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 0 0.909655502477948 0.72647033551795 1.12991400833016 NA NA NA NA NA NA 1224 5) Not assoc w R Now listed Silent mutation no 0 +Capreomycin bacA c.105C>G bacA_c.105C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.1062G>A bacA_c.1062G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.1065T>G bacA_c.1065T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 18.2980327465689 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 35.2688392655279 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.1080G>A bacA_c.1080G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.1140G>A bacA_c.1140G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.1170G>A bacA_c.1170G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.1194C>T bacA_c.1194C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.1210C>T bacA_c.1210C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.1212G>A bacA_c.1212G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.1212G>C bacA_c.1212G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.1242G>A bacA_c.1242G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 24 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.129T>C bacA_c.129T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.1317C>T bacA_c.1317C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.193753017505121 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.1321C>A bacA_c.1321C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.1348C>T bacA_c.1348C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.1371G>A bacA_c.1371G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 11.4504880046624 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 16.0319456706962 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.138C>G bacA_c.138C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.1405C>T bacA_c.1405C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.1428G>A bacA_c.1428G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.1476G>A bacA_c.1476G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.1527C>T bacA_c.1527C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.1533G>A bacA_c.1533G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.1542C>T bacA_c.1542C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 25 2048 15458 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.998385325841245 0.997617338903258 0.998954803937918 0.0384615384615384 0.00097328789333503 0.196369646762539 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.3019140625 0.00735308460242986 1.8464549584842 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 19 1305 8623 0 0 0.00282273611850443 0.997801434853043 0.996568788084241 0.998675817295743 0 0 0.176466911806965 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.41804759493913 NA NA NA NA NA NA 521 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.1572C>T bacA_c.1572C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.1575G>T bacA_c.1575G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.193753017505121 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.1608A>T bacA_c.1608A>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 73 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.1621C>T bacA_c.1621C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.1623G>A bacA_c.1623G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 10 2049 15473 0 0 0.00179871197794837 0.999354130336498 0.998812544515655 0.999690238326549 0 0 0.30849710781876 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.37173073063401 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 8 1305 8634 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.88085962593317 NA NA NA NA NA NA 893 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.1659C>A bacA_c.1659C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.1665G>A bacA_c.1665G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.1782C>T bacA_c.1782C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.1794G>A bacA_c.1794G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.1821T>C bacA_c.1821T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 18.2980327465689 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 16.0319456706962 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.1839G>A bacA_c.1839G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.1842G>A bacA_c.1842G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.1857C>T bacA_c.1857C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.1917G>A bacA_c.1917G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.1917G>C bacA_c.1917G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 40.2367591624089 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.1919A>G bacA_c.1919A>G 2 stop_retained_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.234A>C bacA_c.234A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 40.2367591624089 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.240G>A bacA_c.240G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.243A>G bacA_c.243A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.24895966345574 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 35.2688392655279 NA NA NA NA NA NA 11 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.288C>T bacA_c.288C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.309C>T bacA_c.309C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 11.4504880046624 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 16.0319456706962 NA NA NA NA NA NA 53 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.312G>A bacA_c.312G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.-33C>T bacA_c.-33C>T 2 upstream_gene_variant 2064761 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA c.351C>T bacA_c.351C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.357A>G bacA_c.357A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 18.2980327465689 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.375C>T bacA_c.375C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.438G>A bacA_c.438G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.-50C>T bacA_c.-50C>T 2 upstream_gene_variant 2064778 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA c.516C>T bacA_c.516C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 18.2980327465689 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.558G>A bacA_c.558G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.591C>T bacA_c.591C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.624C>T bacA_c.624C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.193753017505121 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.633C>T bacA_c.633C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.63T>C bacA_c.63T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 12 2049 15471 0 0 0.00179871197794837 0.999224956403797 0.99864654661041 0.999599461575238 0 0 0.264648469397051 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.71972624224414 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 12 1305 8630 0 0 0.00282273611850443 0.998611432538764 0.997575709681241 0.999282307587457 0 0 0.264648469397051 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.38332115036846 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.651G>A bacA_c.651G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA 14 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.-67G>C bacA_c.-67G>C 2 upstream_gene_variant 2064795 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 35.2688392655279 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 3 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA c.681T>G bacA_c.681T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 40.2367591624089 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 35.2688392655279 NA NA NA NA NA NA 14 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.705C>T bacA_c.705C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.714C>G bacA_c.714C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 40.2367591624089 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.759C>A bacA_c.759C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 40.2367591624089 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.-76G>A bacA_c.-76G>A 2 upstream_gene_variant 2064804 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1639 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1094 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA c.783C>T bacA_c.783C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 40.2367591624089 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA c.84G>C bacA_c.84G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin bacA deletion bacA_deletion 2 feature_ablation (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1631 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA LoF bacA_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 27 8 19 17 33 2032 15450 0.00829673011224987 0.00484036444543717 0.013250735092242 0.997868630110443 0.997008054406869 0.998532422825367 0.34 0.212054713435381 0.487652487721588 0.296296296296296 0.137526553940579 0.501813666370001 0.195121951219512 0.0882061016628512 0.348665467451379 3.20140903439701 1.21064838875799 7.6693979849926 0.00969219492115551 19 2386 False False 3.91687544738725 2.04203607615505 7.25122128082042 0.00392156862745098 0.00169452887936675 0.0077123564084357 0.997868630110443 0.997008054406869 0.998532422825367 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 14 4 10 8 20 1297 8622 0.00613026819923371 0.00265021962516072 0.0120431650220116 0.99768572089794 0.996428035548426 0.998585822914007 0.285714285714285 0.132236512571125 0.48666831544894 0.285714285714285 0.0838893183071275 0.581035257183661 0.166666666666666 0.0473536266072571 0.373841713488682 2.65905936777178 0.607750149101102 9.23306350283535 0.0999398310423207 27 1774 False False 0 0 0 0 0 0 0 2.65905936777178 1.01070858166633 6.31735803577524 0.00307455803228285 0.000838329332665637 0.00785322359805673 0.99768572089794 0.996428035548426 0.998585822914007 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Ala170Thr bacA_p.Ala170Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Ala285Thr bacA_p.Ala285Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 35.2688392655279 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Ala289Ser bacA_p.Ala289Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Ala289Val bacA_p.Ala289Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Ala299Thr bacA_p.Ala299Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 18.2968554679321 1 619.5 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 16.0319456706962 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 2 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Ala396Val bacA_p.Ala396Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Ala413Thr bacA_p.Ala413Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Ala438Val bacA_p.Ala438Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Ala464Thr bacA_p.Ala464Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1666 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Ala464Val bacA_p.Ala464Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1632 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Ala474Gly bacA_p.Ala474Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 4 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Ala523Thr bacA_p.Ala523Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Ala630Val bacA_p.Ala630Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 293.33332543886 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1101 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 19 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Ala635Pro bacA_p.Ala635Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1655 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1102 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Arg119Gln bacA_p.Arg119Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1636 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Arg278Cys bacA_p.Arg278Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Arg329Leu bacA_p.Arg329Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1649 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1098 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 2 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Arg356Gln bacA_p.Arg356Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1662 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Arg441Leu bacA_p.Arg441Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Arg452Leu bacA_p.Arg452Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1642 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Arg508Cys bacA_p.Arg508Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1640 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Arg508Pro bacA_p.Arg508Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1654 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Arg545Ser bacA_p.Arg545Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1634 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Arg594His bacA_p.Arg594His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Asn279Thr bacA_p.Asn279Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Asn335Ser bacA_p.Asn335Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1661 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1105 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 6 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Asp178Glu bacA_p.Asp178Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Asp18Asn bacA_p.Asp18Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Asp295Gly bacA_p.Asp295Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1633 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1091 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Asp379fs bacA_p.Asp379fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Asp379His bacA_p.Asp379His 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 1 3 1 3 2048 15480 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999806239100949 0.999433853882399 0.999960040061829 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 2.51953125 0.047970285762596 31.379124977949 0.391760059426727 144.5 2386 False False 2.51953125 0.047970285762596 31.379124977949 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Asp406Ala bacA_p.Asp406Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1650 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Asp451Asn bacA_p.Asp451Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Asp451Glu bacA_p.Asp451Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1667 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Asp509Asn bacA_p.Asp509Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Asp546Ala bacA_p.Asp546Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 9 2049 15474 0 0 0.00179871197794837 0.999418717302848 0.998896832459985 0.999734167184357 0 0 0.336267116879942 0 0 0.841886116991581 0 0 0.336267116879942 0 0 40.2185892912696 1 194.5 2386 False False 0 0 3.82923083971975 0 0 0.00179871197794837 0.999418717302848 0.998896832459985 0.999734167184357 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 257.202999238191 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 31 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Cys538Arg bacA_p.Cys538Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1635 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1092 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Cys538Gly bacA_p.Cys538Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Gln100His bacA_p.Gln100His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1644 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Glu298Asp bacA_p.Glu298Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Glu492Gln bacA_p.Glu492Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Gly105Asp bacA_p.Gly105Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1656 2386 False False Inf 0.193753017505121 Inf 0 0 0.00179958946453767 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Gly168Ser bacA_p.Gly168Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1643 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Gly269Glu bacA_p.Gly269Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1664 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Gly360Arg bacA_p.Gly360Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Gly554fs bacA_p.Gly554fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 8 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Gly584Glu bacA_p.Gly584Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1663 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Gly625Ser bacA_p.Gly625Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Gly72Ala bacA_p.Gly72Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1646 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.His485Arg bacA_p.His485Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.169800530161289 Inf 0.131195335276967 59 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.His615Tyr bacA_p.His615Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Ile273Met bacA_p.Ile273Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Ile273Thr bacA_p.Ile273Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 125 918 1924 14565 0.0610053684724255 0.0510323731880273 0.0722558741588351 0.940709164890525 0.936873312799884 0.94437837586119 0.119846596356663 0.100751093768441 0.141116034939905 NA NA NA 0 0 0.00401032429063891 NA NA NA NA 1627 2386 False True 1.03079606756077 0.843035085328287 1.25182370423976 0 0 0.00191546017376363 0.940709164890525 0.936873312799884 0.94437837586119 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 104 755 1201 7887 0.0796934865900383 0.0655767873076179 0.0957359165658451 0.912635963897246 0.90648478246188 0.918507253187864 0.121071012805587 0.100003807788095 0.144776261151542 NA NA NA 0 0 0.00487401629696828 NA NA NA NA 1087 1774 False True 0 1 1 0 0 0 0 0.904597162408809 0.723235963928104 1.12246452095804 0 0 0.00306679437224624 0.912635963897246 0.90648478246188 0.918507253187864 1226 5) Not assoc w R New NotAwR yes 5 +Capreomycin bacA p.Ile321Thr bacA_p.Ile321Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1660 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Ile443Val bacA_p.Ile443Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Ile520fs bacA_p.Ile520fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Ile520Phe bacA_p.Ile520Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1647 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1096 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Ile54fs bacA_p.Ile54fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Ile603Val bacA_p.Ile603Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 16 961 2033 14522 0.00780868716447047 0.00446973512241491 0.0126499212167889 0.937931925337466 0.934016138110352 0.941682161135234 0.0163766632548618 0.00938890217234928 0.0264587443758511 NA NA NA 0 0 0.00383122629268122 NA NA NA NA 1648 2386 False True 0.118928419885622 0.0675431561082309 0.194700905353675 0 0 0.00181285525856573 0.937931925337466 0.934016138110352 0.941682161135234 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 3 294 1302 8348 0.00229885057471264 0.000474329389656033 0.00670338609202181 0.965980097199722 0.96193974799498 0.969702159230608 0.0101010101010101 0.00208793493004007 0.0292340379977678 NA NA NA 0 0 0.0124688209932715 NA NA NA NA 1097 1774 False True 1 1 1 0 0 0 0 0.0654252484403899 0.0133977063848009 0.193595940553074 0 0 0.00282923090943894 0.965980097199722 0.96193974799498 0.969702159230608 4000 5) Not assoc w R New NotAwR yes 5 +Capreomycin bacA p.Leu175Val bacA_p.Leu175Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Leu44Ser bacA_p.Leu44Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1637 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Leu470fs bacA_p.Leu470fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1668 2386 False False Inf 0.193753017505121 Inf 0 0 0.00179958946453767 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1106 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0 0 0.00282489773306727 1 0.999573236258028 1 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Leu529Pro bacA_p.Leu529Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1629 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1088 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Leu551fs bacA_p.Leu551fs 2 frameshift (see "Genomic_coordinates" sheet) 1 15 4 11 10 16 2039 15467 0.00488042947779404 0.0023427615854433 0.00895691175610291 0.998966608538396 0.99832237803854 0.999409215770894 0.384615384615384 0.20226024365502 0.594292464701408 0.266666666666666 0.0778715462910436 0.551003241036971 0.2 0.0573339970500327 0.436614002996668 2.75839315172321 0.639926961873916 9.31689102840306 0.0880913564605373 34 2386 False False 4.74098822952427 1.92021290686885 11.1276941925529 0.00195790504160548 0.000533712813716262 0.00500536131890901 0.998966608538396 0.99832237803854 0.999409215770894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 1 6 3 9 1302 8633 0.00229885057471264 0.000474329389656033 0.00670338609202181 0.998958574404073 0.998023974495813 0.999523686828456 0.25 0.0548606445279927 0.571858461878189 0.142857142857142 0.00361029686190058 0.578723197043195 0.1 0.00252857854446178 0.445016117028195 1.10509472606246 0.0240068093919583 9.11980149639613 1 275.5 1774 False False 0 0 0 0 0 0 0 2.21018945212493 0.384340065003022 8.86942448063952 0.00076745970836531 1.94302087631205e-05 0.00426851804482144 0.998958574404073 0.998023974495813 0.999523686828456 11 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Leu585Pro bacA_p.Leu585Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Leu75fs bacA_p.Leu75fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1657 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1103 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Lys4Asn bacA_p.Lys4Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 18.2956781909983 1 619.5 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1089 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Lys549Thr bacA_p.Lys549Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 0 9 2049 15474 0 0 0.00179871197794837 0.999418717302848 0.998896832459985 0.999734167184357 0 0 0.336267116879942 0 0 0.369416647552819 0 0 0.336267116879942 0 0 4.42766068883569 0.608192770563446 164.5 2386 False False 0 0 3.82923083971975 0 0 0.00179871197794837 0.999418717302848 0.998896832459985 0.999734167184357 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 1305 8636 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 5.62683462374212 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 5.62683462374212 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Met1? bacA_p.Met1? 2 start_lost (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1658 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1104 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Met131Thr bacA_p.Met131Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Met494Leu bacA_p.Met494Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 18.2980327465689 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Met95Ile bacA_p.Met95Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1651 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1099 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 5 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Phe302fs bacA_p.Phe302fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1665 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Phe384Val bacA_p.Phe384Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1626 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Pro17Leu bacA_p.Pro17Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1641 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Pro347Leu bacA_p.Pro347Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 12 0 12 5 17 2044 15466 0.00244021473889702 0.000792791037816739 0.00568538572188254 0.998902021572046 0.99824261031775 0.999360261118369 0.227272727272727 0.0782062603518925 0.453703623662122 0 0 0.264648469397051 0 0 0.195064322969093 0 0 2.72550213978981 0.382319051588097 142 2386 False False 2.22545182456544 0.64122551001854 6.29216908589867 0 0 0.00180310798912163 0.998902021572046 0.99824261031775 0.999360261118369 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 35.2647591017504 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Pro3Thr bacA_p.Pro3Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Pro437Leu bacA_p.Pro437Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Pro536Arg bacA_p.Pro536Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Pro609His bacA_p.Pro609His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Pro609Ser bacA_p.Pro609Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Ser207Ala bacA_p.Ser207Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Ser481Ala bacA_p.Ser481Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Ser552fs bacA_p.Ser552fs 2 frameshift (see "Genomic_coordinates" sheet) 1 4 2 2 5 5 2044 15478 0.00244021473889702 0.000792791037816739 0.00568538572188254 0.999677065168249 0.999246540104889 0.9998951358908 0.5 0.187086028447398 0.812913971552601 0.5 0.067585986488543 0.932414013511457 0.285714285714285 0.0366925661760855 0.709579136262657 7.57240704500978 0.548498271640437 104.523106382654 0.0695795335511869 33 2386 False False 7.57240704500978 1.74070230834698 32.9298484643654 0.000977517106549364 0.000118403787256337 0.00352662220429432 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 3 3 1302 8639 0.00229885057471264 0.000474329389656033 0.00670338609202181 0.999652858134691 0.998985842622235 0.999928405279598 0.5 0.118117248757025 0.881882751242974 1 0.025 1 0.25 0.00630946320970987 0.805879550316756 Inf 0.170002125056897 Inf 0.131060148863407 29 1774 False False 0 0 0 0 0 0 0 6.63517665130568 0.887465991365636 49.634299611583 0.00076745970836531 1.94302087631205e-05 0.00426851804482144 0.999652858134691 0.998985842622235 0.999928405279598 8 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Ser604Cys bacA_p.Ser604Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Thr112Ala bacA_p.Thr112Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1652 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1100 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 6 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Thr158Ile bacA_p.Thr158Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Thr210Ala bacA_p.Thr210Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Thr419Ala bacA_p.Thr419Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1638 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1093 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Thr419Ile bacA_p.Thr419Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1653 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Thr419Pro bacA_p.Thr419Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Thr436Met bacA_p.Thr436Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1628 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Thr45Ala bacA_p.Thr45Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 6 2 2043 15481 0.00292825768667642 0.00107535359935202 0.00636260998410225 0.999870826067299 0.999533458063883 0.999984356054634 0.75 0.349144205587175 0.968145973750055 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.3548065834156 1 619.5 2386 False False 22.7327459618208 4.06000515080816 229.544026007768 0 0 0.00180398977111688 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 6 2 1299 8640 0.00459770114942528 0.00168908761569561 0.00998021295727147 0.999768572089794 0.999164255486522 0.999971971777513 0.75 0.349144205587175 0.968145973750055 0 0 0.841886116991581 0 0 0.841886116991581 0 0 35.4317467620032 1 503.5 1774 False False 0 0 0 0 0 0 0 19.9538106235565 3.56118467702853 201.783432077479 0 0 0.00283575565681254 0.999768572089794 0.999164255486522 0.999971971777513 6 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Thr467Ser bacA_p.Thr467Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Thr483Ile bacA_p.Thr483Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 18.2980327465689 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Thr506Lys bacA_p.Thr506Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1645 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1095 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Trp122Ser bacA_p.Trp122Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Trp122* bacA_p.Trp122* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1630 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1090 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Trp153Ser bacA_p.Trp153Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 10 0 10 1 10 2048 15473 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999354130336498 0.998812544515655 0.999690238326549 0.0909090909090909 0.00229897221381426 0.412779916988382 0 0 0.30849710781876 0 0 0.30849710781876 0 0 3.37337832467832 0.617999363489049 173 2386 False False 0.755517578125 0.0174007262411499 5.31531885538471 0 0 0.00179958946453767 0.999354130336498 0.998812544515655 0.999690238326549 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 1305 8636 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 5.62683462374212 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 5.62683462374212 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 113 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Trp153* bacA_p.Trp153* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Trp627Arg bacA_p.Trp627Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 1 5 1 5 2048 15478 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999677065168249 0.999246540104889 0.9998951358908 0.166666666666666 0.00421074451448947 0.641234578997674 0.166666666666666 0.00421074451448947 0.641234578997674 0.166666666666666 0.00421074451448947 0.641234578997674 1.5115234375 0.0319423199882685 13.5174010142692 0.525656748323421 156 2386 False False 1.5115234375 0.0319423199882685 13.5174010142692 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Tyr172Cys bacA_p.Tyr172Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Tyr513Cys bacA_p.Tyr513Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Val219Ala bacA_p.Val219Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1659 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Val291Phe bacA_p.Val291Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Val308Ala bacA_p.Val308Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Val351fs bacA_p.Val351fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.169800530161289 Inf 0.131195335276967 59 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Val351Ile bacA_p.Val351Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin bacA p.Val510Ala bacA_p.Val510Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 293.295605628248 1 619.5 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 257.143707584236 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin ccsA c.-106G>C ccsA_c.-106G>C 2 upstream_gene_variant 619785 1 3 0 3 2 18 2047 15465 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.998837434605696 0.998163265407594 0.999310849114122 0.1 0.0123485271702948 0.316982714019082 0 0 0.707598226178713 0 0 0.185301968137852 0 0 18.2981702481517 1 619.5 2386 False False 0.839439830646474 0.0943920341800579 3.51027634190823 0 0 0.00180046780769359 0.998837434605696 0.998163265407594 0.999310849114122 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 2 18 1303 8624 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.997917148808146 0.996710187129532 0.998765117784843 0.1 0.0123485271702948 0.316982714019082 0 0 0.707598226178713 0 0 0.185301968137852 0 0 16.0286935023792 1 503.5 1774 False False 0 0 0 0 0 0 0 0.735396947215826 0.0826589199293504 3.07746031404251 0 0 0.00282706266083767 0.997917148808146 0.996710187129532 0.998765117784843 3 3) Uncertain significance No change no 1 +Capreomycin ccsA c.-107G>A ccsA_c.-107G>A 2 upstream_gene_variant 619784 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1557 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Capreomycin ccsA c.-10G>A ccsA_c.-10G>A 2 upstream_gene_variant 619881 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1564 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1052 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin ccsA c.126C>T ccsA_c.126C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 6 0 2043 15483 0.00292825768667642 0.00107535359935202 0.00636260998410225 1 0.999761774846946 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 8.91348295326886 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 1302 8642 0.00229885057471264 0.000474329389656033 0.00670338609202181 1 0.999573236258028 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 2.73902522369248 Inf NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.-134G>T ccsA_c.-134G>T 2 upstream_gene_variant 619757 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1570 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin ccsA c.139C>T ccsA_c.139C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 195 2045 15288 0.00195217179111761 0.00053214923576723 0.00499072666314977 0.987405541561712 0.985522142505378 0.989102333942637 0.0201005025125628 0.00550321491364047 0.0506629558866433 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.153349633251833 0.0413270433421804 0.399651407494283 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 32 1303 8610 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.996297153436704 0.994776671397899 0.997465918686142 0.0588235294117647 0.00720491743904971 0.196773209335575 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.412989255564082 0.0479046623388498 1.62219200965145 NA NA NA NA NA NA 395 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.-141C>T ccsA_c.-141C>T 2 upstream_gene_variant 619750 NA 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1569 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1055 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin ccsA c.-143G>A ccsA_c.-143G>A 2 upstream_gene_variant 619748 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1560 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin ccsA c.-144C>A ccsA_c.-144C>A 2 upstream_gene_variant 619747 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1561 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin ccsA c.144C>T ccsA_c.144C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.-162G>A ccsA_c.-162G>A 2 upstream_gene_variant 619729 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Capreomycin ccsA c.-16C>T ccsA_c.-16C>T 2 upstream_gene_variant 619875 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1558 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin ccsA c.189C>T ccsA_c.189C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 40.2367591624089 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.18C>T ccsA_c.18C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 18.2980327465689 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.-191C>T ccsA_c.-191C>T 2 upstream_gene_variant 619700 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Capreomycin ccsA c.195G>A ccsA_c.195G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.-22C>A ccsA_c.-22C>A 2 upstream_gene_variant 619869 1 4 0 4 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 11.4497483684733 1 619.5 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Capreomycin ccsA c.231G>T ccsA_c.231G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.234G>C ccsA_c.234G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.27C>T ccsA_c.27C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.-30_-29insGCG ccsA_c.-30_-29insGCG 2 upstream_gene_variant 619861 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin ccsA c.-30A>G ccsA_c.-30A>G 2 upstream_gene_variant 619861 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1578 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1058 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin ccsA c.333C>T ccsA_c.333C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.339C>T ccsA_c.339C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.351C>T ccsA_c.351C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.24895966345574 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 16.0319456706962 NA NA NA NA NA NA 14 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.372C>T ccsA_c.372C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.-38_-37insT ccsA_c.-38_-37insT 2 upstream_gene_variant 619853 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin ccsA c.381C>T ccsA_c.381C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 40.2367591624089 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.390C>T ccsA_c.390C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 5 3 2044 15480 0.00244021473889702 0.000792791037816739 0.00568538572188254 0.999806239100949 0.999433853882399 0.999960040061829 0.625 0.244863216366551 0.914766585862746 NA NA NA NA NA NA NA NA NA NA NA NA False False 12.6223091976516 2.45301748700832 81.2983573866211 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.435G>A ccsA_c.435G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 40.2367591624089 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.468C>T ccsA_c.468C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 11 2047 15472 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.999289543370148 0.998729153244051 0.999645290955256 0.153846153846153 0.0192066719825284 0.454471055676557 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.37425056623884 0.147939198576762 6.30344232307697 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 11 1303 8631 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.998727146493867 0.997723657451287 0.999364430275444 0.153846153846153 0.0192066719825284 0.454471055676557 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.20435358961836 0.129545350164501 5.52664356497091 NA NA NA NA NA NA 21 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.507C>T ccsA_c.507C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.193753017505121 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.519C>T ccsA_c.519C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.525T>C ccsA_c.525T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.528G>A ccsA_c.528G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 18.2980327465689 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 35.2688392655279 NA NA NA NA NA NA 16 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.543C>G ccsA_c.543C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.561G>A ccsA_c.561G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.567C>T ccsA_c.567C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.573C>T ccsA_c.573C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.576C>T ccsA_c.576C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.582C>T ccsA_c.582C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 40.2367591624089 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.585G>A ccsA_c.585G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 18.2980327465689 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.600A>C ccsA_c.600A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.607C>T ccsA_c.607C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.621C>T ccsA_c.621C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.636G>T ccsA_c.636G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 40.2367591624089 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.663T>C ccsA_c.663T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 21 210 2028 15273 0.0102489019033674 0.00635511128056527 0.0156240716423959 0.98643673706646 0.98448824901892 0.988199145139541 0.0909090909090909 0.0571571579175187 0.135605615694174 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.753106508875739 0.455454750978552 1.18490622578342 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 5 48 1300 8594 0.00383141762452107 0.00124518543639507 0.00891842567874012 0.994445730155056 0.992642512993299 0.995901964130712 0.0943396226415094 0.0313468057286531 0.20658532500501 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 0 0.688621794871794 0.213514093814078 1.72586371526874 NA NA NA NA NA NA 55 5) Not assoc w R Now listed Silent mutation no 0 +Capreomycin ccsA c.666C>T ccsA_c.666C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.673C>T ccsA_c.673C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.687C>A ccsA_c.687C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.696C>T ccsA_c.696C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 18.2980327465689 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.69G>A ccsA_c.69G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.-69G>T ccsA_c.-69G>T 2 upstream_gene_variant 619822 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1552 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 14 3) Uncertain significance New Uncertain no 0 +Capreomycin ccsA c.708C>T ccsA_c.708C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.720C>T ccsA_c.720C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 40.2367591624089 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 35.2688392655279 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.729G>A ccsA_c.729G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 7 2045 15476 0.00195217179111761 0.00053214923576723 0.00499072666314977 0.999547891235548 0.999068706427379 0.999818210125054 0.363636363636363 0.109263443819098 0.692095284988322 NA NA NA NA NA NA NA NA NA NA NA NA False False 4.32441494935382 0.927363234590696 17.0258143672646 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 4 7 1301 8635 0.00306513409961685 0.000835757856895071 0.00782921001204628 0.999190002314279 0.998331811834773 0.999674278877205 0.363636363636363 0.109263443819098 0.692095284988322 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.79268694410892 0.812848296477441 14.9402647561689 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.72G>A ccsA_c.72G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 18.2980327465689 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.732G>A ccsA_c.732G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.762C>T ccsA_c.762C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.-76G>C ccsA_c.-76G>C 2 upstream_gene_variant 619815 1 5 0 5 4 5 2045 15478 0.00195217179111761 0.00053214923576723 0.00499072666314977 0.999677065168249 0.999246540104889 0.9998951358908 0.444444444444444 0.136995662265166 0.787991493221131 0 0 0.521823750104981 0 0 0.521823750104981 0 0 8.2651034636894 1 619.5 2386 False False 6.05496332518337 1.20025687575651 28.1731568275793 0 0 0.00180222706872706 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 4 5 1301 8637 0.00306513409961685 0.000835757856895071 0.00782921001204628 0.999421430224485 0.99865033199523 0.999812114132187 0.444444444444444 0.136995662265166 0.787991493221131 0 0 0.521823750104981 0 0 0.521823750104981 0 0 7.25239440638574 1 503.5 1774 False False 0 0 0 0 0 0 0 5.31099154496541 1.05216858758495 24.7018089616901 0 0 0.00283140248651778 0.999421430224485 0.99865033199523 0.999812114132187 22 3) Uncertain significance No change no 1 +Capreomycin ccsA c.771C>T ccsA_c.771C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 40.2367591624089 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.-77G>A ccsA_c.-77G>A 2 upstream_gene_variant 619814 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin ccsA c.-77G>T ccsA_c.-77G>T 2 upstream_gene_variant 619814 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 12 3) Uncertain significance No change no 1 +Capreomycin ccsA c.78G>A ccsA_c.78G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 18.2980327465689 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA 11 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.795G>A ccsA_c.795G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.-79C>T ccsA_c.-79C>T 2 upstream_gene_variant 619812 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin ccsA c.819G>A ccsA_c.819G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 40.2367591624089 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 35.2688392655279 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.843G>A ccsA_c.843G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.-85G>A ccsA_c.-85G>A 2 upstream_gene_variant 619806 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1566 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin ccsA c.870C>A ccsA_c.870C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.879C>G ccsA_c.879C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.894C>T ccsA_c.894C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.193753017505121 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.-89G>A ccsA_c.-89G>A 2 upstream_gene_variant 619802 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1572 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1056 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance No change no 1 +Capreomycin ccsA c.918T>C ccsA_c.918T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.963G>C ccsA_c.963G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.-96C>A ccsA_c.-96C>A 2 upstream_gene_variant 619795 NA 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1565 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1053 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 1 3) Uncertain significance New Uncertain no 0 +Capreomycin ccsA c.972C>T ccsA_c.972C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin ccsA c.-99C>T ccsA_c.-99C>T 2 upstream_gene_variant 619792 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1562 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin ccsA p.Ala11Val ccsA_p.Ala11Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin ccsA p.Ala166Val ccsA_p.Ala166Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin ccsA p.Ala189Thr ccsA_p.Ala189Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 10 1 2039 15482 0.00488042947779404 0.0023427615854433 0.00895691175610291 0.99993541303365 0.999640197578315 0.999998364800924 0.909090909090909 0.587220083011617 0.997701027786185 0 0 0.975 0 0 0.975 0 0 294.784264797491 1 619.5 2386 False False 75.9293771456596 10.7876072891074 3232.0502660065 0 0 0.00180752554043533 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1049 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0 0 0.00282489773306727 1 0.999573236258028 1 4 3) Uncertain significance New Uncertain no 0 +Capreomycin ccsA p.Ala211Val ccsA_p.Ala211Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin ccsA p.Ala229Ser ccsA_p.Ala229Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 5 3 2044 15480 0.00244021473889702 0.000792791037816739 0.00568538572188254 0.999806239100949 0.999433853882399 0.999960040061829 0.625 0.244863216366551 0.914766585862746 0 0 0.975 0 0 0.707598226178713 0 0 294.028670335654 1 619.5 2386 False False 12.6223091976516 2.45301748700832 81.2983573866211 0 0 0.00180310798912163 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Capreomycin ccsA p.Ala229Val ccsA_p.Ala229Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1563 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1051 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin ccsA p.Ala281Glu ccsA_p.Ala281Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin ccsA p.Ala298Ser ccsA_p.Ala298Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin ccsA p.Arg217Gln ccsA_p.Arg217Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1574 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1057 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin ccsA p.Arg217Gly ccsA_p.Arg217Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 40.2341634723554 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Capreomycin ccsA p.Arg217Leu ccsA_p.Arg217Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1553 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1046 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin ccsA p.Arg217Trp ccsA_p.Arg217Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance No change no 1 +Capreomycin ccsA p.Arg257Cys ccsA_p.Arg257Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 0 15 2049 15468 0 0 0.00179871197794837 0.999031195504747 0.998402606935329 0.999457669301639 0 0 0.218019360910534 0 0 0.369416647552819 0 0 0.218019360910534 0 0 4.42594407274044 0.608182919249958 160 2386 False False 0 0 2.10669629306639 0 0 0.00179871197794837 0.999031195504747 0.998402606935329 0.999457669301639 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 9 1305 8633 0 0 0.00282273611850443 0.998958574404073 0.998023974495813 0.999523686828456 0 0 0.336267116879942 0 0 0.521823750104981 0 0 0.336267116879942 0 0 7.22679773171691 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 3.35590194387839 0 0 0.00282273611850443 0.998958574404073 0.998023974495813 0.999523686828456 77 3) Uncertain significance No change no 1 +Capreomycin ccsA p.Arg288Gln ccsA_p.Arg288Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin ccsA p.Asp226Asn ccsA_p.Asp226Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 1 4 2 7 2047 15476 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.999547891235548 0.999068706427379 0.999818210125054 0.222222222222222 0.0281449734778982 0.600093573716312 0.2 0.00505076337946806 0.716417936118089 0.125 0.0031597235312519 0.526509670875206 1.89008304836345 0.0383607409808768 19.1106709205594 0.462770103551188 148 2386 False False 2.16009491241538 0.218788540583066 11.351113176461 0.00048828125 1.23621345180143e-05 0.00271749449396634 0.999547891235548 0.999068706427379 0.999818210125054 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 1304 8640 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999768572089794 0.999164255486522 0.999971971777513 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 257.399447522812 1 503.5 1774 False False 0 0 0 0 0 0 0 3.31288343558282 0.056110603773561 63.7302235362974 0 0 0.00282489773306727 0.999768572089794 0.999164255486522 0.999971971777513 6 3) Uncertain significance No change no 1 +Capreomycin ccsA p.Glu74Ala ccsA_p.Glu74Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 293.33332543886 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Capreomycin ccsA p.Gly324Ser ccsA_p.Gly324Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin ccsA p.Gly43Arg ccsA_p.Gly43Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin ccsA p.Gly52Arg ccsA_p.Gly52Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin ccsA p.Gly9Ser ccsA_p.Gly9Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin ccsA p.His5Asn ccsA_p.His5Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1575 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Capreomycin ccsA p.Ile123Ala ccsA_p.Ile123Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1559 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1050 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 7 3) Uncertain significance New Uncertain no 0 +Capreomycin ccsA p.Ile245Met ccsA_p.Ile245Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 959 6025 1090 9458 0.468033186920449 0.446242863501785 0.489915100413512 0.610863527740102 0.603131297859165 0.618554082259334 0.137313860252004 0.129322926630443 0.145608860783929 NA NA NA 0 0 0.000612074755836953 NA NA NA NA NA NA False True 1.38112939205908 1.25753887544593 1.51666176631518 0 0 0.00337857281218988 0.610863527740102 0.603131297859165 0.618554082259334 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 678 3734 627 4908 0.519540229885057 0.492031979376208 0.546960289829627 0.567924091645452 0.557400807980446 0.57840155228132 0.153671804170444 0.143148985403425 0.164655244738152 NA NA NA 0 0 0.000987428468651471 NA NA NA NA NA NA False True 0 1 1 0 0 1 0 1.42132172228301 1.26259847946409 1.59998763511836 0 0 0.00586610711917581 0.567924091645452 0.557400807980446 0.57840155228132 8361 Not assoc w R 5) Not assoc w R No change yes 1 +Capreomycin ccsA p.Ile245Val ccsA_p.Ile245Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1568 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1054 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 5 3) Uncertain significance New Uncertain no 0 +Capreomycin ccsA p.Ile63Val ccsA_p.Ile63Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin ccsA p.Ile88Val ccsA_p.Ile88Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin ccsA p.Leu279Val ccsA_p.Leu279Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin ccsA p.Leu317Val ccsA_p.Leu317Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Capreomycin ccsA p.Phe186Ser ccsA_p.Phe186Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1576 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin ccsA p.Phe237Leu ccsA_p.Phe237Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Capreomycin ccsA p.Phe242Leu ccsA_p.Phe242Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 6 3) Uncertain significance New Uncertain no 0 +Capreomycin ccsA p.Phe305Val ccsA_p.Phe305Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin ccsA p.Phe308Leu ccsA_p.Phe308Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1555 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin ccsA p.Pro144Ser ccsA_p.Pro144Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 18.2956781909983 1 619.5 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 35.2647591017504 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 12 3) Uncertain significance No change no 1 +Capreomycin ccsA p.Pro61Leu ccsA_p.Pro61Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 1 2048 15482 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.99993541303365 0.999640197578315 0.999998364800924 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.19374050358025 Inf 0.116878672066624 105.5 2386 False False 7.5595703125 0.096257452000026 590.418198079286 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.169800530161289 Inf 0.131195335276967 59 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 30 3) Uncertain significance No change no 1 +Capreomycin ccsA p.Pro71Leu ccsA_p.Pro71Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 3) Uncertain significance No change no 1 +Capreomycin ccsA p.Ser193Asn ccsA_p.Ser193Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin ccsA p.Ser283Ala ccsA_p.Ser283Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1573 2386 False False Inf 0.193753017505121 Inf 0 0 0.00179958946453767 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin ccsA p.Thr19Pro ccsA_p.Thr19Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin ccsA p.Thr200Ile ccsA_p.Thr200Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1567 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin ccsA p.Thr224Pro ccsA_p.Thr224Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1554 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1047 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin ccsA p.Thr314Ala ccsA_p.Thr314Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1577 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Capreomycin ccsA p.Thr3Met ccsA_p.Thr3Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 6 3) Uncertain significance No change no 1 +Capreomycin ccsA p.Thr56Ala ccsA_p.Thr56Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 8 3) Uncertain significance No change no 1 +Capreomycin ccsA p.Tyr134His ccsA_p.Tyr134His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1571 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 17 3) Uncertain significance No change no 1 +Capreomycin ccsA p.Tyr170Cys ccsA_p.Tyr170Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1556 2386 False False Inf 0.193753017505121 Inf 0 0 0.00179958946453767 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1048 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0 0 0.00282489773306727 1 0.999573236258028 1 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin ccsA p.Tyr85Asp ccsA_p.Tyr85Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin ccsA p.Tyr85Cys ccsA_p.Tyr85Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin ccsA p.Val27Ile ccsA_p.Val27Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 73 422 1976 15061 0.0356271351878965 0.0280278918792527 0.0445892561628142 0.972744300200219 0.970056706630337 0.975252233783379 0.147474747474747 0.117412027855648 0.181820795116385 NA NA NA 0 0 0.00870332537380858 NA NA NA NA NA NA False True 1.31849132720609 1.00943675083984 1.70201458407802 0 0 0.00186510036364645 0.972744300200219 0.970056706630337 0.975252233783379 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 72 415 1233 8227 0.0551724137931034 0.0434160481194783 0.0689790824167337 0.951978708632261 0.947258212260922 0.956391391280869 0.147843942505133 0.117511254418962 0.182526775669737 NA NA NA 0 0 0.00884947697850546 NA NA NA NA NA NA False True 0 0 0 0 0 1 0 1.15761146776888 0.882140749767934 1.50152528027011 0 0 0.00298732098392945 0.951978708632261 0.947258212260922 0.956391391280869 119 Not assoc w R Previous WHO guidance 4) Not assoc w R - Interim DOWN from NotAwR to NotAwRI yes Prev. WHO 3 +Capreomycin ccsA p.Val76Ile ccsA_p.Val76Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin rrl n.1004G>C rrl_n.1004G>C 2 non_coding_transcript_exon_variant 1474661 NA 0 0 0 2 0 2047 15483 0.000976085895558809 0.000118230396782607 0.00352146535805941 1 0.999761774846946 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2264 2386 False False Inf 1.41952099860885 Inf 0 0 0.00180046780769359 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1006C>T rrl_n.1006C>T 2 non_coding_transcript_exon_variant 1474663 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2311 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1708 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 18 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1007G>T rrl_n.1007G>T 2 non_coding_transcript_exon_variant 1474664 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2265 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1667 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1009T>G rrl_n.1009T>G 2 non_coding_transcript_exon_variant 1474666 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1706 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1140 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.100T>G rrl_n.100T>G 2 non_coding_transcript_exon_variant 1473757 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1913 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1339 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1013C>G rrl_n.1013C>G 2 non_coding_transcript_exon_variant 1474670 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2138 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1549 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1014C>G rrl_n.1014C>G 2 non_coding_transcript_exon_variant 1474671 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1778 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1015C>T rrl_n.1015C>T 2 non_coding_transcript_exon_variant 1474672 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2312 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1709 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 8 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1016T>C rrl_n.1016T>C 2 non_coding_transcript_exon_variant 1474673 NA 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1843 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1274 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1019T>A rrl_n.1019T>A 2 non_coding_transcript_exon_variant 1474676 NA 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1844 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1275 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 14 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1019T>C rrl_n.1019T>C 2 non_coding_transcript_exon_variant 1474676 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2182 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1590 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 7 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.101G>A rrl_n.101G>A 2 non_coding_transcript_exon_variant 1473758 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2038 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1455 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.101G>T rrl_n.101G>T 2 non_coding_transcript_exon_variant 1473758 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2057 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1475 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 6 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1020A>G rrl_n.1020A>G 2 non_coding_transcript_exon_variant 1474677 NA 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1999 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1418 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 8 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1022G>C rrl_n.1022G>C 2 non_coding_transcript_exon_variant 1474679 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1972 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1394 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1027T>C rrl_n.1027T>C 2 non_coding_transcript_exon_variant 1474684 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2249 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1653 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1030C>A rrl_n.1030C>A 2 non_coding_transcript_exon_variant 1474687 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1817 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1249 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1031G>C rrl_n.1031G>C 2 non_coding_transcript_exon_variant 1474688 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2139 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1550 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1033C>T rrl_n.1033C>T 2 non_coding_transcript_exon_variant 1474690 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2106 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1521 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1035G>A rrl_n.1035G>A 2 non_coding_transcript_exon_variant 1474692 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1914 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1340 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 8 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1044C>A rrl_n.1044C>A 2 non_coding_transcript_exon_variant 1474701 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1049G>A rrl_n.1049G>A 2 non_coding_transcript_exon_variant 1474706 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2351 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1745 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1049G>T rrl_n.1049G>T 2 non_coding_transcript_exon_variant 1474706 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1051_1052insT rrl_n.1051_1052insT 2 non_coding_transcript_exon_variant 1474708 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1052_1060delGTGGTGTAAinsAATAAGTTAG rrl_n.1052_1060delGTGGTGTAAinsAATAAGTTAG 2 non_coding_transcript_exon_variant 1474709 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2291 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1691 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1052dupG rrl_n.1052dupG 2 non_coding_transcript_exon_variant 1474708 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1818 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1250 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1052G>T rrl_n.1052G>T 2 non_coding_transcript_exon_variant 1474709 1 0 0 0 0 6 2049 15477 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1973 2386 False False 0 0 6.41986758323506 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 1305 8636 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1395 1774 False False 0 0 0 0 0 0 0 0 0 5.62683462374212 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 714 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1053_1054delTG rrl_n.1053_1054delTG 2 non_coding_transcript_exon_variant 1474708 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1758 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1193 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1053_1056delTGGT rrl_n.1053_1056delTGGT 2 non_coding_transcript_exon_variant 1474709 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2183 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1591 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 11 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1053_1063delTGGTGTAAAGCinsACAAGTCCAAGAGT rrl_n.1053_1063delTGGTGTAAAGCinsACAAGTCCAAGAGT 2 non_coding_transcript_exon_variant 1474710 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1819 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1251 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1053T>G rrl_n.1053T>G 2 non_coding_transcript_exon_variant 1474710 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1974 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1396 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1054G>T rrl_n.1054G>T 2 non_coding_transcript_exon_variant 1474711 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1868 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1299 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1057_1059delGTAinsAAGTG rrl_n.1057_1059delGTAinsAAGTG 2 non_coding_transcript_exon_variant 1474714 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2058 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1476 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1059_1060delAAinsGAG rrl_n.1059_1060delAAinsGAG 2 non_coding_transcript_exon_variant 1474716 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2107 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1522 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1060A>G rrl_n.1060A>G 2 non_coding_transcript_exon_variant 1474717 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1060A>T rrl_n.1060A>T 2 non_coding_transcript_exon_variant 1474717 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1759 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1194 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1061delA rrl_n.1061delA 2 non_coding_transcript_exon_variant 1474715 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1798 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1232 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1065T>C rrl_n.1065T>C 2 non_coding_transcript_exon_variant 1474722 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1799 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1233 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 9 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1075A>G rrl_n.1075A>G 2 non_coding_transcript_exon_variant 1474732 1 5 0 5 0 6 2049 15477 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 8.24842676385937 1 619.5 2386 False False 0 0 6.41986758323506 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 5 1305 8637 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 10.0352432576349 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 7.23014561016525 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 80 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1077G>T rrl_n.1077G>T 2 non_coding_transcript_exon_variant 1474734 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1869 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1300 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 20 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1086T>G rrl_n.1086T>G 2 non_coding_transcript_exon_variant 1474743 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1688 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1126 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1089G>C rrl_n.1089G>C 2 non_coding_transcript_exon_variant 1474746 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1090C>A rrl_n.1090C>A 2 non_coding_transcript_exon_variant 1474747 NA 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2332 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1727 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1092C>T rrl_n.1092C>T 2 non_coding_transcript_exon_variant 1474749 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2059 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1477 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 15 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1093C>T rrl_n.1093C>T 2 non_coding_transcript_exon_variant 1474750 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 35.2688392655279 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 27 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1096_1097delACinsT rrl_n.1096_1097delACinsT 2 non_coding_transcript_exon_variant 1474753 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1845 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1276 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1096A>G rrl_n.1096A>G 2 non_coding_transcript_exon_variant 1474753 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1733 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1167 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1097delC rrl_n.1097delC 2 non_coding_transcript_exon_variant 1474753 NA 0 0 0 0 6 2049 15477 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1734 2386 False False 0 0 6.41986758323506 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 5 1305 8637 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1168 1774 False False 0 0 0 0 0 0 0 0 0 7.23014561016525 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 18 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.109G>A rrl_n.109G>A 2 non_coding_transcript_exon_variant 1473766 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2266 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1668 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1103A>G rrl_n.1103A>G 2 non_coding_transcript_exon_variant 1474760 NA 0 0 0 0 8 2049 15475 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1820 2386 False False 0 0 4.42794679154129 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 8 1305 8634 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1252 1774 False False 0 0 0 0 0 0 0 0 0 3.88085962593317 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 40 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1107dupG rrl_n.1107dupG 2 non_coding_transcript_exon_variant 1474761 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1120T>C rrl_n.1120T>C 2 non_coding_transcript_exon_variant 1474777 NA 0 0 0 0 7 2049 15476 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 2017 2386 False True 0 0 5.24430081649792 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 5 1305 8637 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1435 1774 False True 0 1 1 0 0 0 0 0 0 7.23014561016525 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 22 5) Not assoc w R New NotAwR yes 5 +Capreomycin rrl n.1122G>A rrl_n.1122G>A 2 non_coding_transcript_exon_variant 1474779 NA 0 0 0 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 2140 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1551 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 30 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1123C>T rrl_n.1123C>T 2 non_coding_transcript_exon_variant 1474780 NA 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1760 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1195 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 16 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1125G>A rrl_n.1125G>A 2 non_coding_transcript_exon_variant 1474782 NA 0 0 0 0 9 2049 15474 0 0 0.00179871197794837 0.999418717302848 0.998896832459985 0.999734167184357 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1735 2386 False True 0 0 3.82923083971975 0 0 0.00179871197794837 0.999418717302848 0.998896832459985 0.999734167184357 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 7 1305 8635 0 0 0.00282273611850443 0.999190002314279 0.998331811834773 0.999674278877205 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1169 1774 False True 0 1 1 0 0 0 0 0 0 4.59639609856608 0 0 0.00282273611850443 0.999190002314279 0.998331811834773 0.999674278877205 31 5) Not assoc w R New NotAwR yes 5 +Capreomycin rrl n.1133C>A rrl_n.1133C>A 2 non_coding_transcript_exon_variant 1474790 1 2 1 1 1 1 2048 15482 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.99993541303365 0.999640197578315 0.999998364800924 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 7.5595703125 0.096257452000026 590.418198079286 0.220090832740563 119.5 2386 False False 7.5595703125 0.096257452000026 590.418198079286 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 1304 8641 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999884286044897 0.999355453609522 0.999997070380594 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 6.62653374233128 0.0843535983905244 517.917818294861 0.245189914752491 93.5 1774 False False 0 0 0 0 0 0 0 6.62653374233128 0.0843535983905244 517.917818294861 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1133C>T rrl_n.1133C>T 2 non_coding_transcript_exon_variant 1474790 NA 0 0 0 0 8 2049 15475 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1846 2386 False False 0 0 4.42794679154129 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 6 1305 8636 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1277 1774 False False 0 0 0 0 0 0 0 0 0 5.62683462374212 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 10 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1137C>A rrl_n.1137C>A 2 non_coding_transcript_exon_variant 1474794 NA 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2039 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1456 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 5 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1137C>T rrl_n.1137C>T 2 non_coding_transcript_exon_variant 1474794 NA 0 0 0 0 12 2049 15471 0 0 0.00179871197794837 0.999224956403797 0.99864654661041 0.999599461575238 0 0 0.264648469397051 NA NA NA 0 0 0.264648469397051 NA NA NA NA 2087 2386 False False 0 0 2.71972624224414 0 0 0.00179871197794837 0.999224956403797 0.99864654661041 0.999599461575238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 12 1305 8630 0 0 0.00282273611850443 0.998611432538764 0.997575709681241 0.999282307587457 0 0 0.264648469397051 NA NA NA 0 0 0.264648469397051 NA NA NA NA 1502 1774 False False 0 0 0 0 0 0 0 0 0 2.38332115036846 0 0 0.00282273611850443 0.998611432538764 0.997575709681241 0.999282307587457 54 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.113T>C rrl_n.113T>C 2 non_coding_transcript_exon_variant 1473770 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2040 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1457 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.113T>G rrl_n.113T>G 2 non_coding_transcript_exon_variant 1473770 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1821 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1253 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1140_1141insTATA rrl_n.1140_1141insTATA 2 non_coding_transcript_exon_variant 1474797 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1707 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1141 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1141C>T rrl_n.1141C>T 2 non_coding_transcript_exon_variant 1474798 NA 0 0 0 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 2313 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1710 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 10 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1144_1147delGTGC rrl_n.1144_1147delGTGC 2 non_coding_transcript_exon_variant 1474800 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2060 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1478 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1144G>A rrl_n.1144G>A 2 non_coding_transcript_exon_variant 1474801 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2184 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1592 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1145T>C rrl_n.1145T>C 2 non_coding_transcript_exon_variant 1474802 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1887 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1315 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1146G>A rrl_n.1146G>A 2 non_coding_transcript_exon_variant 1474803 NA 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1761 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1196 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 8 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1147C>T rrl_n.1147C>T 2 non_coding_transcript_exon_variant 1474804 NA 0 0 0 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 2018 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1436 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 6 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1155G>A rrl_n.1155G>A 2 non_coding_transcript_exon_variant 1474812 NA 0 0 0 2 9 2047 15474 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.999418717302848 0.998896832459985 0.999734167184357 0.181818181818181 0.0228311982999596 0.517755852360172 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1762 2386 False False 1.67985670086305 0.176481355552764 8.12348790592676 0 0 0.00180046780769359 0.999418717302848 0.998896832459985 0.999734167184357 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 8 1304 8634 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999074288359176 0.998176798225858 0.999600261389848 0.111111111111111 0.00280913674659921 0.482496514917337 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1197 1774 False False 0 0 0 0 0 0 0 0.827645705521472 0.0186379987589414 6.18187193560828 0 0 0.00282489773306727 0.999074288359176 0.998176798225858 0.999600261389848 15 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1166C>G rrl_n.1166C>G 2 non_coding_transcript_exon_variant 1474823 NA 0 0 0 2 18 2047 15465 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.998837434605696 0.998163265407594 0.999310849114122 0.1 0.0123485271702948 0.316982714019082 NA NA NA 0 0 0.185301968137852 NA NA NA NA 1933 2386 False False 0.839439830646474 0.0943920341800579 3.51027634190823 0 0 0.00180046780769359 0.998837434605696 0.998163265407594 0.999310849114122 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 16 1304 8626 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.998148576718352 0.996995141231936 0.998941392909931 0.0588235294117647 0.00148817439126663 0.28688939666722 NA NA NA 0 0 0.205907214207822 NA NA NA NA 1357 1774 False False 0 0 0 0 0 0 0 0.413439417177914 0.00985471042276387 2.66580958878246 0 0 0.00282489773306727 0.998148576718352 0.996995141231936 0.998941392909931 56 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1167A>G rrl_n.1167A>G 2 non_coding_transcript_exon_variant 1474824 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1822 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1254 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 18 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1170C>T rrl_n.1170C>T 2 non_coding_transcript_exon_variant 1474827 NA 0 0 0 2 10 2047 15473 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.999354130336498 0.998812544515655 0.999690238326549 0.166666666666666 0.0208625254600923 0.484137748685967 NA NA NA 0 0 0.30849710781876 NA NA NA NA 1823 2386 False False 1.51177332681973 0.160920229387323 7.10098638741896 0 0 0.00180046780769359 0.999354130336498 0.998812544515655 0.999690238326549 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 8 1304 8634 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999074288359176 0.998176798225858 0.999600261389848 0.111111111111111 0.00280913674659921 0.482496514917337 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1255 1774 False False 0 0 0 0 0 0 0 0.827645705521472 0.0186379987589414 6.18187193560828 0 0 0.00282489773306727 0.999074288359176 0.998176798225858 0.999600261389848 43 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1173A>G rrl_n.1173A>G 2 non_coding_transcript_exon_variant 1474830 NA 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1975 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1397 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 33 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1173A>T rrl_n.1173A>T 2 non_coding_transcript_exon_variant 1474830 NA 0 0 0 2 7 2047 15476 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.999547891235548 0.999068706427379 0.999818210125054 0.222222222222222 0.0281449734778982 0.600093573716312 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1736 2386 False False 2.16009491241538 0.218788540583066 11.351113176461 0 0 0.00180046780769359 0.999547891235548 0.999068706427379 0.999818210125054 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 6 1304 8636 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999305716269382 0.998489453757575 0.999745168847445 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1170 1774 False False 0 0 0 0 0 0 0 1.10378323108384 0.0239783465953148 9.10896322125085 0 0 0.00282489773306727 0.999305716269382 0.998489453757575 0.999745168847445 18 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1174A>C rrl_n.1174A>C 2 non_coding_transcript_exon_variant 1474831 NA 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1800 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1234 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 9 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1174A>G rrl_n.1174A>G 2 non_coding_transcript_exon_variant 1474831 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1976 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1398 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 9 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1174A>T rrl_n.1174A>T 2 non_coding_transcript_exon_variant 1474831 NA 0 0 0 2 7 2047 15476 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.999547891235548 0.999068706427379 0.999818210125054 0.222222222222222 0.0281449734778982 0.600093573716312 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1708 2386 False False 2.16009491241538 0.218788540583066 11.351113176461 0 0 0.00180046780769359 0.999547891235548 0.999068706427379 0.999818210125054 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 6 1304 8636 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999305716269382 0.998489453757575 0.999745168847445 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1142 1774 False False 0 0 0 0 0 0 0 1.10378323108384 0.0239783465953148 9.10896322125085 0 0 0.00282489773306727 0.999305716269382 0.998489453757575 0.999745168847445 26 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1175A>T rrl_n.1175A>T 2 non_coding_transcript_exon_variant 1474832 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1915 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1341 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 14 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1182C>T rrl_n.1182C>T 2 non_coding_transcript_exon_variant 1474839 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1709 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1143 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 30 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1187G>T rrl_n.1187G>T 2 non_coding_transcript_exon_variant 1474844 NA 0 0 0 3 14 2046 15469 0.00146412884333821 0.000302040401839334 0.00427278776332334 0.999095782471097 0.998483341560662 0.999505570487652 0.176470588235294 0.0379850680706259 0.434317872844283 NA NA NA 0 0 0.231635761650116 NA NA NA NA 2204 2386 False False 1.62012987012987 0.298292433443589 5.81217329995604 0 0 0.00180134700867096 0.999095782471097 0.998483341560662 0.999505570487652 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 11 1303 8631 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.998727146493867 0.997723657451287 0.999364430275444 0.153846153846153 0.0192066719825284 0.454471055676557 NA NA NA 0 0 0.284914152918154 NA NA NA NA 1612 1774 False False 0 0 0 0 0 0 0 1.20435358961836 0.129545350164501 5.52664356497091 0 0 0.00282706266083767 0.998727146493867 0.997723657451287 0.999364430275444 55 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.11C>T rrl_n.11C>T 2 non_coding_transcript_exon_variant 1473668 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1847 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1278 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1207C>T rrl_n.1207C>T 2 non_coding_transcript_exon_variant 1474864 NA 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 2041 2386 False True 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1458 1774 False True 1 1 1 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 83 5) Not assoc w R New NotAwR yes 5 +Capreomycin rrl n.1208_1212delCCTTGinsTCATTT rrl_n.1208_1212delCCTTGinsTCATTT 2 non_coding_transcript_exon_variant 1474865 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2042 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1459 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1209C>A rrl_n.1209C>A 2 non_coding_transcript_exon_variant 1474866 NA 0 0 0 3 13 2046 15470 0.00146412884333821 0.000302040401839334 0.00427278776332334 0.999160369437447 0.998564634148971 0.999552858749588 0.1875 0.0404737339059459 0.456456546231611 NA NA NA 0 0 0.24705263800047 NA NA NA NA 1848 2386 False False 1.74486803519061 0.318666463767885 6.35740137399336 0 0 0.00180134700867096 0.999160369437447 0.998564634148971 0.999552858749588 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 10 1303 8632 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.99884286044897 0.997873012135272 0.999444971558315 0.166666666666666 0.0208625254600923 0.484137748685967 NA NA NA 0 0 0.30849710781876 NA NA NA NA 1279 1774 False False 0 0 0 0 0 0 0 1.32494244052187 0.141022691102851 6.22733061547632 0 0 0.00282706266083767 0.99884286044897 0.997873012135272 0.999444971558315 60 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1212G>C rrl_n.1212G>C 2 non_coding_transcript_exon_variant 1474869 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2205 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1613 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 10 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1212G>T rrl_n.1212G>T 2 non_coding_transcript_exon_variant 1474869 NA 0 0 0 3 12 2046 15471 0.00146412884333821 0.000302040401839334 0.00427278776332334 0.999224956403797 0.99864654661041 0.999599461575238 0.2 0.0433120051058366 0.480891133806853 NA NA NA 0 0 0.264648469397051 NA NA NA NA 2352 2386 False False 1.89039589442815 0.342039926832047 7.01364416786877 0 0 0.00180134700867096 0.999224956403797 0.99864654661041 0.999599461575238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 9 1303 8633 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.998958574404073 0.998023974495813 0.999523686828456 0.181818181818181 0.0228311982999596 0.517755852360172 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1746 1774 False False 0 0 0 0 0 0 0 1.47232881384838 0.154604541408076 7.12417170347034 0 0 0.00282706266083767 0.998958574404073 0.998023974495813 0.999523686828456 68 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1228G>A rrl_n.1228G>A 2 non_coding_transcript_exon_variant 1474885 NA 0 0 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2108 2386 False False Inf 0.193753017505121 Inf 0 0 0.00179958946453767 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1523 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0 0 0.00282489773306727 1 0.999573236258028 1 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1235G>A rrl_n.1235G>A 2 non_coding_transcript_exon_variant 1474892 NA 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2250 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1654 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 55 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1239A>G rrl_n.1239A>G 2 non_coding_transcript_exon_variant 1474896 NA 0 0 0 3 13 2046 15470 0.00146412884333821 0.000302040401839334 0.00427278776332334 0.999160369437447 0.998564634148971 0.999552858749588 0.1875 0.0404737339059459 0.456456546231611 NA NA NA 0 0 0.24705263800047 NA NA NA NA 2061 2386 False False 1.74486803519061 0.318666463767885 6.35740137399336 0 0 0.00180134700867096 0.999160369437447 0.998564634148971 0.999552858749588 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 11 1303 8631 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.998727146493867 0.997723657451287 0.999364430275444 0.153846153846153 0.0192066719825284 0.454471055676557 NA NA NA 0 0 0.284914152918154 NA NA NA NA 1479 1774 False False 0 0 0 0 0 0 0 1.20435358961836 0.129545350164501 5.52664356497091 0 0 0.00282706266083767 0.998727146493867 0.997723657451287 0.999364430275444 78 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1239A>T rrl_n.1239A>T 2 non_coding_transcript_exon_variant 1474896 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1934 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1358 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1245T>C rrl_n.1245T>C 2 non_coding_transcript_exon_variant 1474902 NA 0 0 0 3 13 2046 15470 0.00146412884333821 0.000302040401839334 0.00427278776332334 0.999160369437447 0.998564634148971 0.999552858749588 0.1875 0.0404737339059459 0.456456546231611 NA NA NA 0 0 0.24705263800047 NA NA NA NA 1952 2386 False False 1.74486803519061 0.318666463767885 6.35740137399336 0 0 0.00180134700867096 0.999160369437447 0.998564634148971 0.999552858749588 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 11 1303 8631 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.998727146493867 0.997723657451287 0.999364430275444 0.153846153846153 0.0192066719825284 0.454471055676557 NA NA NA 0 0 0.284914152918154 NA NA NA NA 1376 1774 False False 0 0 0 0 0 0 0 1.20435358961836 0.129545350164501 5.52664356497091 0 0 0.00282706266083767 0.998727146493867 0.997723657451287 0.999364430275444 69 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1246T>C rrl_n.1246T>C 2 non_coding_transcript_exon_variant 1474903 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1669 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1108 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 36 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1247G>C rrl_n.1247G>C 2 non_coding_transcript_exon_variant 1474904 NA 0 0 0 3 17 2046 15466 0.00146412884333821 0.000302040401839334 0.00427278776332334 0.998902021572046 0.99824261031775 0.999360261118369 0.15 0.0320709371854637 0.378926826545313 NA NA NA 0 0 0.195064322969093 NA NA NA NA 2185 2386 False False 1.33396584440227 0.250238761332698 4.61785482983457 0 0 0.00180134700867096 0.998902021572046 0.99824261031775 0.999360261118369 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 15 1303 8627 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.998264290673455 0.997138824765365 0.999028221442365 0.117647058823529 0.0145793168403025 0.36440916210125 NA NA NA 0 0 0.218019360910534 NA NA NA NA 1593 1774 False False 0 0 0 0 0 0 0 0.882783320542338 0.0978469652919409 3.80289192088908 0 0 0.00282706266083767 0.998264290673455 0.997138824765365 0.999028221442365 99 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1248T>C rrl_n.1248T>C 2 non_coding_transcript_exon_variant 1474905 NA 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2267 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1669 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 25 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1256T>A rrl_n.1256T>A 2 non_coding_transcript_exon_variant 1474913 NA 0 0 0 3 13 2046 15470 0.00146412884333821 0.000302040401839334 0.00427278776332334 0.999160369437447 0.998564634148971 0.999552858749588 0.1875 0.0404737339059459 0.456456546231611 NA NA NA 0 0 0.24705263800047 NA NA NA NA 2186 2386 False False 1.74486803519061 0.318666463767885 6.35740137399336 0 0 0.00180134700867096 0.999160369437447 0.998564634148971 0.999552858749588 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 11 1303 8631 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.998727146493867 0.997723657451287 0.999364430275444 0.153846153846153 0.0192066719825284 0.454471055676557 NA NA NA 0 0 0.284914152918154 NA NA NA NA 1594 1774 False False 0 0 0 0 0 0 0 1.20435358961836 0.129545350164501 5.52664356497091 0 0 0.00282706266083767 0.998727146493867 0.997723657451287 0.999364430275444 61 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1256T>C rrl_n.1256T>C 2 non_coding_transcript_exon_variant 1474913 NA 0 0 0 0 8 2049 15475 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 2141 2386 False False 0 0 4.42794679154129 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 8 1305 8634 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1552 1774 False False 0 0 0 0 0 0 0 0 0 3.88085962593317 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 34 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1263G>A rrl_n.1263G>A 2 non_coding_transcript_exon_variant 1474920 NA 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1977 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1399 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 7 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1263G>C rrl_n.1263G>C 2 non_coding_transcript_exon_variant 1474920 NA 0 0 0 3 9 2046 15474 0.00146412884333821 0.000302040401839334 0.00427278776332334 0.999418717302848 0.998896832459985 0.999734167184357 0.25 0.0548606445279927 0.571858461878189 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1710 2386 False False 2.52101661779081 0.438613660248458 10.1118325034892 0 0 0.00180134700867096 0.999418717302848 0.998896832459985 0.999734167184357 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 7 1303 8635 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.999190002314279 0.998331811834773 0.999674278877205 0.222222222222222 0.0281449734778982 0.600093573716312 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1144 1774 False False 0 0 0 0 0 0 0 1.89343273763841 0.191695673798278 9.95987601380279 0 0 0.00282706266083767 0.999190002314279 0.998331811834773 0.999674278877205 45 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1264C>T rrl_n.1264C>T 2 non_coding_transcript_exon_variant 1474921 1 2 0 2 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 0 0 0.841886116991581 0 0 0.521823750104981 0 0 40.2289720864225 1 619.5 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1171 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 37 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1266G>A rrl_n.1266G>A 2 non_coding_transcript_exon_variant 1474923 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1275C>T rrl_n.1275C>T 2 non_coding_transcript_exon_variant 1474932 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2109 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1524 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 19 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1276A>G rrl_n.1276A>G 2 non_coding_transcript_exon_variant 1474933 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2251 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1655 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1277C>T rrl_n.1277C>T 2 non_coding_transcript_exon_variant 1474934 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2187 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1595 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1288C>T rrl_n.1288C>T 2 non_coding_transcript_exon_variant 1474945 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 35.2688392655279 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1295A>G rrl_n.1295A>G 2 non_coding_transcript_exon_variant 1474952 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2062 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1296C>T rrl_n.1296C>T 2 non_coding_transcript_exon_variant 1474953 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1849 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1280 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.-12delT rrl_n.-12delT 2 upstream_gene_variant 1473645 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1797 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1231 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 13 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1301A>G rrl_n.1301A>G 2 non_coding_transcript_exon_variant 1474958 1 8 0 8 0 8 2049 15475 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 4.42794679154129 0.608194416780565 166 2386 False False 0 0 4.42794679154129 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 1305 8636 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 5.62683462374212 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 5.62683462374212 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1305T>C rrl_n.1305T>C 2 non_coding_transcript_exon_variant 1474962 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1306G>T rrl_n.1306G>T 2 non_coding_transcript_exon_variant 1474963 NA 0 0 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2110 2386 False False Inf 0.193753017505121 Inf 0 0 0.00179958946453767 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1315G>A rrl_n.1315G>A 2 non_coding_transcript_exon_variant 1474972 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.131A>G rrl_n.131A>G 2 non_coding_transcript_exon_variant 1473788 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1801 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1235 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1331C>T rrl_n.1331C>T 2 non_coding_transcript_exon_variant 1474988 NA 0 0 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2206 2386 False False Inf 0.193753017505121 Inf 0 0 0.00179958946453767 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1333C>T rrl_n.1333C>T 2 non_coding_transcript_exon_variant 1474990 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1953 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1377 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1334T>G rrl_n.1334T>G 2 non_coding_transcript_exon_variant 1474991 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1954 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1378 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1338T>C rrl_n.1338T>C 2 non_coding_transcript_exon_variant 1474995 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2161 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1571 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1340A>G rrl_n.1340A>G 2 non_coding_transcript_exon_variant 1474997 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2207 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1614 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1342C>T rrl_n.1342C>T 2 non_coding_transcript_exon_variant 1474999 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2142 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1553 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1351C>A rrl_n.1351C>A 2 non_coding_transcript_exon_variant 1475008 1 5 0 5 0 6 2049 15477 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 8.24842676385937 1 619.5 2386 False False 0 0 6.41986758323506 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 257.202999238191 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 21 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1360delGinsTA rrl_n.1360delGinsTA 2 non_coding_transcript_exon_variant 1475017 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1802 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1236 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1360G>A rrl_n.1360G>A 2 non_coding_transcript_exon_variant 1475017 1 4 0 4 1 5 2048 15478 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999677065168249 0.999246540104889 0.9998951358908 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.602364635616474 0 0 0.521823750104981 0 0 11.4553414106133 1 619.5 2386 False False 1.5115234375 0.0319423199882685 13.5174010142692 0 0 0.00179958946453767 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 1 5 1304 8637 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999421430224485 0.99865033199523 0.999812114132187 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.602364635616474 0 0 0.521823750104981 0 0 10.0429442724162 1 275.5 1774 False False 0 0 0 0 0 0 0 1.32469325153374 0.0279864197449639 11.8514948120722 0 0 0.00282489773306727 0.999421430224485 0.99865033199523 0.999812114132187 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1374G>C rrl_n.1374G>C 2 non_coding_transcript_exon_variant 1475031 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1779 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1213 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1374G>T rrl_n.1374G>T 2 non_coding_transcript_exon_variant 1475031 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2292 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1692 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1384A>G rrl_n.1384A>G 2 non_coding_transcript_exon_variant 1475041 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1392C>T rrl_n.1392C>T 2 non_coding_transcript_exon_variant 1475049 1 3 0 3 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 18.2956781909983 1 619.5 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 16.0319456706962 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 8 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1404C>A rrl_n.1404C>A 2 non_coding_transcript_exon_variant 1475061 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1850 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1281 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1404C>T rrl_n.1404C>T 2 non_coding_transcript_exon_variant 1475061 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1711 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1145 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1404delC rrl_n.1404delC 2 non_coding_transcript_exon_variant 1475060 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2111 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1525 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1405A>G rrl_n.1405A>G 2 non_coding_transcript_exon_variant 1475062 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1803 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1237 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1405A>T rrl_n.1405A>T 2 non_coding_transcript_exon_variant 1475062 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2268 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1670 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1406delA rrl_n.1406delA 2 non_coding_transcript_exon_variant 1475061 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1670 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1109 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1408G>A rrl_n.1408G>A 2 non_coding_transcript_exon_variant 1475065 1 1 0 1 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 293.33332543886 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1460 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1410A>G rrl_n.1410A>G 2 non_coding_transcript_exon_variant 1475067 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2208 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1615 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1419C>A rrl_n.1419C>A 2 non_coding_transcript_exon_variant 1475076 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2228 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1633 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1422T>C rrl_n.1422T>C 2 non_coding_transcript_exon_variant 1475079 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2112 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1526 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1424C>T rrl_n.1424C>T 2 non_coding_transcript_exon_variant 1475081 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1935 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1359 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1430G>T rrl_n.1430G>T 2 non_coding_transcript_exon_variant 1475087 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1978 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1433A>C rrl_n.1433A>C 2 non_coding_transcript_exon_variant 1475090 1 1 0 1 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 293.33332543886 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 11 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1433A>T rrl_n.1433A>T 2 non_coding_transcript_exon_variant 1475090 NA 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1936 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1360 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1440G>A rrl_n.1440G>A 2 non_coding_transcript_exon_variant 1475097 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1447T>A rrl_n.1447T>A 2 non_coding_transcript_exon_variant 1475104 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2353 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1747 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 7 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1452C>T rrl_n.1452C>T 2 non_coding_transcript_exon_variant 1475109 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1780 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1214 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1456C>T rrl_n.1456C>T 2 non_coding_transcript_exon_variant 1475113 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1979 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1400 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1457C>T rrl_n.1457C>T 2 non_coding_transcript_exon_variant 1475114 1 4 0 4 0 8 2049 15475 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 0 0 0.369416647552819 0 0 0.602364635616474 0 0 0.369416647552819 0 0 11.44752945988 1 619.5 2386 False False 0 0 4.42794679154129 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 8 1305 8634 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 0 0 0.369416647552819 0 0 0.602364635616474 0 0 0.369416647552819 0 0 10.0317583828862 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 3.88085962593317 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 19 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1459G>A rrl_n.1459G>A 2 non_coding_transcript_exon_variant 1475116 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2063 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1480 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 6 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1463G>T rrl_n.1463G>T 2 non_coding_transcript_exon_variant 1475120 NA 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2043 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1461 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1465C>T rrl_n.1465C>T 2 non_coding_transcript_exon_variant 1475122 NA 0 0 0 1 7 2048 15476 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999547891235548 0.999068706427379 0.999818210125054 0.125 0.0031597235312519 0.526509670875206 NA NA NA 0 0 0.409616397225003 NA NA NA NA 2044 2386 False False 1.07952008928571 0.02394099779516 8.40970244475376 0 0 0.00179958946453767 0.999547891235548 0.999068706427379 0.999818210125054 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 5 1304 8637 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999421430224485 0.99865033199523 0.999812114132187 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1462 1774 False False 0 0 0 0 0 0 0 1.32469325153374 0.0279864197449639 11.8514948120722 0 0 0.00282489773306727 0.999421430224485 0.99865033199523 0.999812114132187 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1467A>T rrl_n.1467A>T 2 non_coding_transcript_exon_variant 1475124 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1937 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1361 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 18 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1472G>A rrl_n.1472G>A 2 non_coding_transcript_exon_variant 1475129 NA 0 0 0 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1870 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1301 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 10 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1472G>T rrl_n.1472G>T 2 non_coding_transcript_exon_variant 1475129 NA 0 0 0 1 5 2048 15478 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999677065168249 0.999246540104889 0.9998951358908 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1916 2386 False False 1.5115234375 0.0319423199882685 13.5174010142692 0 0 0.00179958946453767 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 4 1304 8638 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999537144179588 0.998815333169806 0.999873873427139 0.2 0.00505076337946806 0.716417936118089 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1342 1774 False False 0 0 0 0 0 0 0 1.65605828220858 0.0336017769800931 16.7446524584225 0 0 0.00282489773306727 0.999537144179588 0.998815333169806 0.999873873427139 25 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1477G>A rrl_n.1477G>A 2 non_coding_transcript_exon_variant 1475134 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2045 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1463 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1480A>T rrl_n.1480A>T 2 non_coding_transcript_exon_variant 1475137 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2113 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1527 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 20 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1487G>C rrl_n.1487G>C 2 non_coding_transcript_exon_variant 1475144 NA 0 0 0 1 4 2048 15479 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999741652134599 0.999338660174897 0.999929604559257 0.2 0.00505076337946806 0.716417936118089 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1851 2386 False False 1.8895263671875 0.0383494517213545 19.1050373764475 0 0 0.00179958946453767 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 3 1304 8639 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999652858134691 0.998985842622235 0.999928405279598 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1282 1774 False False 0 0 0 0 0 0 0 2.20833333333333 0.0420336930075031 27.526218938507 0 0 0.00282489773306727 0.999652858134691 0.998985842622235 0.999928405279598 13 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1488C>T rrl_n.1488C>T 2 non_coding_transcript_exon_variant 1475145 NA 0 0 0 1 3 2048 15480 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999806239100949 0.999433853882399 0.999960040061829 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1824 2386 False False 2.51953125 0.047970285762596 31.379124977949 0 0 0.00179958946453767 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 3 1304 8639 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999652858134691 0.998985842622235 0.999928405279598 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1256 1774 False False 0 0 0 0 0 0 0 2.20833333333333 0.0420336930075031 27.526218938507 0 0 0.00282489773306727 0.999652858134691 0.998985842622235 0.999928405279598 8 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1494C>T rrl_n.1494C>T 2 non_coding_transcript_exon_variant 1475151 NA 0 0 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2088 2386 False False Inf 0.193753017505121 Inf 0 0 0.00179958946453767 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1503 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0 0 0.00282489773306727 1 0.999573236258028 1 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1497C>A rrl_n.1497C>A 2 non_coding_transcript_exon_variant 1475154 NA 0 0 0 1 7 2048 15476 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999547891235548 0.999068706427379 0.999818210125054 0.125 0.0031597235312519 0.526509670875206 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1980 2386 False False 1.07952008928571 0.02394099779516 8.40970244475376 0 0 0.00179958946453767 0.999547891235548 0.999068706427379 0.999818210125054 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 5 1304 8637 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999421430224485 0.99865033199523 0.999812114132187 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1401 1774 False False 0 0 0 0 0 0 0 1.32469325153374 0.0279864197449639 11.8514948120722 0 0 0.00282489773306727 0.999421430224485 0.99865033199523 0.999812114132187 10 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1499G>A rrl_n.1499G>A 2 non_coding_transcript_exon_variant 1475156 NA 0 0 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1852 2386 False False Inf 0.193753017505121 Inf 0 0 0.00179958946453767 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1283 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0 0 0.00282489773306727 1 0.999573236258028 1 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.149C>T rrl_n.149C>T 2 non_coding_transcript_exon_variant 1473806 NA 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1737 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1172 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1505G>A rrl_n.1505G>A 2 non_coding_transcript_exon_variant 1475162 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2143 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1554 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1506T>G rrl_n.1506T>G 2 non_coding_transcript_exon_variant 1475163 NA 0 0 0 1 4 2048 15479 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999741652134599 0.999338660174897 0.999929604559257 0.2 0.00505076337946806 0.716417936118089 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1955 2386 False False 1.8895263671875 0.0383494517213545 19.1050373764475 0 0 0.00179958946453767 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 3 1304 8639 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999652858134691 0.998985842622235 0.999928405279598 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1379 1774 False False 0 0 0 0 0 0 0 2.20833333333333 0.0420336930075031 27.526218938507 0 0 0.00282489773306727 0.999652858134691 0.998985842622235 0.999928405279598 14 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.150T>C rrl_n.150T>C 2 non_coding_transcript_exon_variant 1473807 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1738 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1173 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1510T>A rrl_n.1510T>A 2 non_coding_transcript_exon_variant 1475167 NA 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1888 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1316 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1514C>T rrl_n.1514C>T 2 non_coding_transcript_exon_variant 1475171 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1956 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1380 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 21 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1518G>A rrl_n.1518G>A 2 non_coding_transcript_exon_variant 1475175 NA 0 0 0 1 8 2048 15475 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999483304269198 0.998982158652985 0.999776901906193 0.111111111111111 0.00280913674659921 0.482496514917337 NA NA NA 0 0 0.369416647552819 NA NA NA NA 2229 2386 False False 0.94451904296875 0.021275762868979 7.05211630192235 0 0 0.00179958946453767 0.999483304269198 0.998982158652985 0.999776901906193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 6 1304 8636 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999305716269382 0.998489453757575 0.999745168847445 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1634 1774 False False 0 0 0 0 0 0 0 1.10378323108384 0.0239783465953148 9.10896322125085 0 0 0.00282489773306727 0.999305716269382 0.998489453757575 0.999745168847445 19 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1518G>C rrl_n.1518G>C 2 non_coding_transcript_exon_variant 1475175 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1957 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1381 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 12 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1525T>A rrl_n.1525T>A 2 non_coding_transcript_exon_variant 1475182 NA 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2209 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1616 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1531C>G rrl_n.1531C>G 2 non_coding_transcript_exon_variant 1475188 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2019 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1437 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1531C>T rrl_n.1531C>T 2 non_coding_transcript_exon_variant 1475188 NA 0 0 0 1 6 2048 15477 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999612478201898 0.999156720468893 0.999857773477374 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA 0 0 0.4592581264399 NA NA NA NA 2314 2386 False False 1.259521484375 0.0273691036001646 10.3895811388841 0 0 0.00179958946453767 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 4 1304 8638 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999537144179588 0.998815333169806 0.999873873427139 0.2 0.00505076337946806 0.716417936118089 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1711 1774 False False 0 0 0 0 0 0 0 1.65605828220858 0.0336017769800931 16.7446524584225 0 0 0.00282489773306727 0.999537144179588 0.998815333169806 0.999873873427139 10 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1545G>C rrl_n.1545G>C 2 non_coding_transcript_exon_variant 1475202 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1981 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1402 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1549C>T rrl_n.1549C>T 2 non_coding_transcript_exon_variant 1475206 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2230 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1635 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1551C>T rrl_n.1551C>T 2 non_coding_transcript_exon_variant 1475208 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1552G>A rrl_n.1552G>A 2 non_coding_transcript_exon_variant 1475209 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1938 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1362 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1552G>C rrl_n.1552G>C 2 non_coding_transcript_exon_variant 1475209 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1982 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1403 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1556C>T rrl_n.1556C>T 2 non_coding_transcript_exon_variant 1475213 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2293 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1693 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.155G>A rrl_n.155G>A 2 non_coding_transcript_exon_variant 1473812 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1781 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1215 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.155G>T rrl_n.155G>T 2 non_coding_transcript_exon_variant 1473812 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1739 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1174 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1563G>A rrl_n.1563G>A 2 non_coding_transcript_exon_variant 1475220 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2294 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1563G>T rrl_n.1563G>T 2 non_coding_transcript_exon_variant 1475220 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2064 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1481 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1565G>A rrl_n.1565G>A 2 non_coding_transcript_exon_variant 1475222 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1572dupA rrl_n.1572dupA 2 non_coding_transcript_exon_variant 1475227 0 0 0 0 1 3 2048 15480 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999806239100949 0.999433853882399 0.999960040061829 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2269 2386 False False 2.51953125 0.047970285762596 31.379124977949 0 0 0.00179958946453767 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1573C>T rrl_n.1573C>T 2 non_coding_transcript_exon_variant 1475230 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.157A>C rrl_n.157A>C 2 non_coding_transcript_exon_variant 1473814 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1763 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1198 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.157A>G rrl_n.157A>G 2 non_coding_transcript_exon_variant 1473814 1 2 0 2 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 40.2341634723554 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 35.2647591017504 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.157A>T rrl_n.157A>T 2 non_coding_transcript_exon_variant 1473814 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2114 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1528 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1583C>T rrl_n.1583C>T 2 non_coding_transcript_exon_variant 1475240 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 6 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1584C>G rrl_n.1584C>G 2 non_coding_transcript_exon_variant 1475241 NA 0 0 0 8 24 2041 15459 0.00390434358223523 0.00168707939779644 0.00767854500622988 0.998449912807595 0.997694465417801 0.999006585264568 0.25 0.114616005102588 0.434049374922242 NA NA NA 0 0 0.142473597722525 NA NA NA NA 2020 2386 False False 2.52474277315041 0.979094815578653 5.81813452008281 0 0 0.00180575592497059 0.998449912807595 0.997694465417801 0.999006585264568 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1438 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1587A>T rrl_n.1587A>T 2 non_coding_transcript_exon_variant 1475244 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.158T>C rrl_n.158T>C 2 non_coding_transcript_exon_variant 1473815 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2089 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1504 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.158T>G rrl_n.158T>G 2 non_coding_transcript_exon_variant 1473815 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2090 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1505 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1592T>C rrl_n.1592T>C 2 non_coding_transcript_exon_variant 1475249 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1689 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1593dupC rrl_n.1593dupC 2 non_coding_transcript_exon_variant 1475249 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1764 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1199 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1598_1599insT rrl_n.1598_1599insT 2 non_coding_transcript_exon_variant 1475255 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2231 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1636 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1598C>T rrl_n.1598C>T 2 non_coding_transcript_exon_variant 1475255 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.159C>G rrl_n.159C>G 2 non_coding_transcript_exon_variant 1473816 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2021 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1439 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1602T>G rrl_n.1602T>G 2 non_coding_transcript_exon_variant 1475259 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2252 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1608delG rrl_n.1608delG 2 non_coding_transcript_exon_variant 1475260 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2162 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1609T>C rrl_n.1609T>C 2 non_coding_transcript_exon_variant 1475266 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1958 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1382 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.160T>C rrl_n.160T>C 2 non_coding_transcript_exon_variant 1473817 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1939 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1363 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1613G>C rrl_n.1613G>C 2 non_coding_transcript_exon_variant 1475270 NA 0 0 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1959 2386 False False Inf 0.193753017505121 Inf 0 0 0.00179958946453767 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1383 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0 0 0.00282489773306727 1 0.999573236258028 1 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1624dupC rrl_n.1624dupC 2 non_coding_transcript_exon_variant 1475280 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1625T>A rrl_n.1625T>A 2 non_coding_transcript_exon_variant 1475282 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1628G>A rrl_n.1628G>A 2 non_coding_transcript_exon_variant 1475285 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2270 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1671 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1634A>C rrl_n.1634A>C 2 non_coding_transcript_exon_variant 1475291 NA 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2333 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1728 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1640C>G rrl_n.1640C>G 2 non_coding_transcript_exon_variant 1475297 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2000 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1419 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1642G>A rrl_n.1642G>A 2 non_coding_transcript_exon_variant 1475299 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1650T>G rrl_n.1650T>G 2 non_coding_transcript_exon_variant 1475307 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2271 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1672 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1658A>T rrl_n.1658A>T 2 non_coding_transcript_exon_variant 1475315 NA 0 0 0 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 2315 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 5 1305 8637 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1712 1774 False False 0 0 0 0 0 0 0 0 0 7.23014561016525 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 5 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.165A>G rrl_n.165A>G 2 non_coding_transcript_exon_variant 1473822 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1690 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1127 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1660G>A rrl_n.1660G>A 2 non_coding_transcript_exon_variant 1475317 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1691 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1128 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1663T>C rrl_n.1663T>C 2 non_coding_transcript_exon_variant 1475320 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1664G>T rrl_n.1664G>T 2 non_coding_transcript_exon_variant 1475321 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2316 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1713 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.168_169dupTA rrl_n.168_169dupTA 2 non_coding_transcript_exon_variant 1473819 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1680C>T rrl_n.1680C>T 2 non_coding_transcript_exon_variant 1475337 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1853 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1284 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1681G>A rrl_n.1681G>A 2 non_coding_transcript_exon_variant 1475338 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1671 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1110 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1682T>G rrl_n.1682T>G 2 non_coding_transcript_exon_variant 1475339 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1854 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1285 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1683A>G rrl_n.1683A>G 2 non_coding_transcript_exon_variant 1475340 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1712 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1146 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1685C>G rrl_n.1685C>G 2 non_coding_transcript_exon_variant 1475342 NA 0 0 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1765 2386 False False Inf 0.193753017505121 Inf 0 0 0.00179958946453767 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1200 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0 0 0.00282489773306727 1 0.999573236258028 1 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1687G>A rrl_n.1687G>A 2 non_coding_transcript_exon_variant 1475344 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1696A>T rrl_n.1696A>T 2 non_coding_transcript_exon_variant 1475353 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1672 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1111 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1697A>G rrl_n.1697A>G 2 non_coding_transcript_exon_variant 1475354 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2295 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1694 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1698C>T rrl_n.1698C>T 2 non_coding_transcript_exon_variant 1475355 1 9 0 9 0 11 2049 15472 0 0 0.00179871197794837 0.999289543370148 0.998729153244051 0.999645290955256 0 0 0.284914152918154 0 0 0.336267116879942 0 0 0.284914152918154 0 0 3.82873586251759 0.6107346856487 171 2386 False False 0 0 3.01101772028239 0 0 0.00179871197794837 0.999289543370148 0.998729153244051 0.999645290955256 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 8 1305 8634 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 0 0 0.369416647552819 0 0 0.4592581264399 0 0 0.369416647552819 0 0 5.62553173508625 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 3.88085962593317 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 7 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.-16T>G rrl_n.-16T>G 2 upstream_gene_variant 1473642 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2203 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1611 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1706C>T rrl_n.1706C>T 2 non_coding_transcript_exon_variant 1475363 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1804 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1238 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1716G>A rrl_n.1716G>A 2 non_coding_transcript_exon_variant 1475373 1 17 0 17 0 17 2049 15466 0 0 0.00179871197794837 0.998902021572046 0.99824261031775 0.999360261118369 0 0 0.195064322969093 0 0 0.195064322969093 0 0 0.195064322969093 0 0 1.830868357271 0.249315922753043 129 2386 False False 0 0 1.830868357271 0 0 0.00179871197794837 0.998902021572046 0.99824261031775 0.999360261118369 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 16 0 16 0 16 1305 8626 0 0 0.00282273611850443 0.998148576718352 0.996995141231936 0.998941392909931 0 0 0.205907214207822 0 0 0.205907214207822 0 0 0.205907214207822 0 0 1.71646889297801 0.25348410775634 98.5 1774 False False 0 0 0 0 0 0 0 0 0 1.71646889297801 0 0 0.00282273611850443 0.998148576718352 0.996995141231936 0.998941392909931 11 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1718G>A rrl_n.1718G>A 2 non_coding_transcript_exon_variant 1475375 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2065 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1482 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.171G>A rrl_n.171G>A 2 non_coding_transcript_exon_variant 1473828 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1721A>T rrl_n.1721A>T 2 non_coding_transcript_exon_variant 1475378 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2253 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1656 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1722G>C rrl_n.1722G>C 2 non_coding_transcript_exon_variant 1475379 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2163 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1572 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1722G>T rrl_n.1722G>T 2 non_coding_transcript_exon_variant 1475379 NA 0 0 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2001 2386 False False Inf 0.193753017505121 Inf 0 0 0.00179958946453767 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1723C>A rrl_n.1723C>A 2 non_coding_transcript_exon_variant 1475380 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2272 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1673 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1723C>T rrl_n.1723C>T 2 non_coding_transcript_exon_variant 1475380 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1960 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.172G>C rrl_n.172G>C 2 non_coding_transcript_exon_variant 1473829 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1766 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1201 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.173_176delTGCGinsCGTGT rrl_n.173_176delTGCGinsCGTGT 2 non_coding_transcript_exon_variant 1473830 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2022 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1440 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1736C>T rrl_n.1736C>T 2 non_coding_transcript_exon_variant 1475393 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.174G>A rrl_n.174G>A 2 non_coding_transcript_exon_variant 1473831 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.174G>T rrl_n.174G>T 2 non_coding_transcript_exon_variant 1473831 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2232 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1637 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.175C>T rrl_n.175C>T 2 non_coding_transcript_exon_variant 1473832 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2188 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1596 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.176_177insT rrl_n.176_177insT 2 non_coding_transcript_exon_variant 1473833 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2002 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1420 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 8 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1760G>A rrl_n.1760G>A 2 non_coding_transcript_exon_variant 1475417 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1762C>T rrl_n.1762C>T 2 non_coding_transcript_exon_variant 1475419 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2273 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1674 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1771G>A rrl_n.1771G>A 2 non_coding_transcript_exon_variant 1475428 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1871 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1302 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1772G>A rrl_n.1772G>A 2 non_coding_transcript_exon_variant 1475429 NA 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2254 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1657 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1772G>T rrl_n.1772G>T 2 non_coding_transcript_exon_variant 1475429 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2210 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1617 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1776A>T rrl_n.1776A>T 2 non_coding_transcript_exon_variant 1475433 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1855 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1286 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1785C>G rrl_n.1785C>G 2 non_coding_transcript_exon_variant 1475442 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1889 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1785C>T rrl_n.1785C>T 2 non_coding_transcript_exon_variant 1475442 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1786G>A rrl_n.1786G>A 2 non_coding_transcript_exon_variant 1475443 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1825 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1257 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1788T>A rrl_n.1788T>A 2 non_coding_transcript_exon_variant 1475445 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1788T>C rrl_n.1788T>C 2 non_coding_transcript_exon_variant 1475445 1 3 0 3 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 18.2980327465689 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.178G>A rrl_n.178G>A 2 non_coding_transcript_exon_variant 1473835 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1692 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1794T>C rrl_n.1794T>C 2 non_coding_transcript_exon_variant 1475451 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1795C>A rrl_n.1795C>A 2 non_coding_transcript_exon_variant 1475452 NA 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1917 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1343 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1795C>T rrl_n.1795C>T 2 non_coding_transcript_exon_variant 1475452 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1803A>G rrl_n.1803A>G 2 non_coding_transcript_exon_variant 1475460 1 2 1 1 1 2 2048 15481 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999870826067299 0.999533458063883 0.999984356054634 0.333333333333333 0.00840375865961264 0.905700675949754 0.5 0.012579117093425 0.987420882906574 0.333333333333333 0.00840375865961264 0.905700675949754 7.55908203125 0.0962512346208006 590.380272511971 0.220102608229516 126 2386 False False 3.779541015625 0.0640320806562028 72.4657839845296 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1464 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1811C>T rrl_n.1811C>T 2 non_coding_transcript_exon_variant 1475468 1 2 0 2 2 3 2047 15480 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.999806239100949 0.999433853882399 0.999960040061829 0.4 0.0527449505263169 0.853367200365326 0 0 0.841886116991581 0 0 0.707598226178713 0 0 40.2734336471682 1 619.5 2386 False False 5.04152418172936 0.420787897776746 44.0540252618051 0 0 0.00180046780769359 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 2 3 1303 8639 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.999652858134691 0.998985842622235 0.999928405279598 0.4 0.0527449505263169 0.853367200365326 0 0 0.841886116991581 0 0 0.707598226178713 0 0 35.3188889836217 1 503.5 1774 False False 0 0 0 0 0 0 0 4.42005628037861 0.368763684490018 38.622243637886 0 0 0.00282706266083767 0.999652858134691 0.998985842622235 0.999928405279598 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1812C>T rrl_n.1812C>T 2 non_coding_transcript_exon_variant 1475469 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2233 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1638 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1818C>T rrl_n.1818C>T 2 non_coding_transcript_exon_variant 1475475 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2354 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1748 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1821dupG rrl_n.1821dupG 2 non_coding_transcript_exon_variant 1475477 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1782 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1822C>G rrl_n.1822C>G 2 non_coding_transcript_exon_variant 1475479 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1940 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1364 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1822C>T rrl_n.1822C>T 2 non_coding_transcript_exon_variant 1475479 1 0 0 0 4 29 2045 15454 0.00195217179111761 0.00053214923576723 0.00499072666314977 0.998126977975844 0.997311126912655 0.998745260027249 0.121212121212121 0.0340328814229786 0.28201622853722 NA NA NA 0 0 0.119444869069502 NA NA NA NA 2003 2386 False False 1.04234044347019 0.265969532871451 2.97276550437543 0 0 0.00180222706872706 0.998126977975844 0.997311126912655 0.998745260027249 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 9 1304 8633 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.998958574404073 0.998023974495813 0.999523686828456 0.1 0.00252857854446178 0.445016117028195 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1421 1774 False False 0 0 0 0 0 0 0 0.735599863667348 0.0167698879909291 5.31583775548636 0 0 0.00282489773306727 0.998958574404073 0.998023974495813 0.999523686828456 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1823A>T rrl_n.1823A>T 2 non_coding_transcript_exon_variant 1475480 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1783 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1216 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1824C>G rrl_n.1824C>G 2 non_coding_transcript_exon_variant 1475481 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2317 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1714 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1825A>G rrl_n.1825A>G 2 non_coding_transcript_exon_variant 1475482 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1826 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1258 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1826C>T rrl_n.1826C>T 2 non_coding_transcript_exon_variant 1475483 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1983 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1404 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.182G>A rrl_n.182G>A 2 non_coding_transcript_exon_variant 1473839 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1740 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1175 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1830C>T rrl_n.1830C>T 2 non_coding_transcript_exon_variant 1475487 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2004 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1422 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1842C>T rrl_n.1842C>T 2 non_coding_transcript_exon_variant 1475499 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1890 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1317 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1847C>A rrl_n.1847C>A 2 non_coding_transcript_exon_variant 1475504 1 6 0 6 0 7 2049 15476 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 6.41945279027998 1 619.5 2386 False False 0 0 5.24430081649792 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 35.2647591017504 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 23 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1848G>A rrl_n.1848G>A 2 non_coding_transcript_exon_variant 1475505 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2296 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1695 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1851A>T rrl_n.1851A>T 2 non_coding_transcript_exon_variant 1475508 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1741 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1176 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 8 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1852C>A rrl_n.1852C>A 2 non_coding_transcript_exon_variant 1475509 1 1 1 0 1 1 2048 15482 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.99993541303365 0.999640197578315 0.999998364800924 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.19374050358025 Inf 0.116878672066624 105.5 2386 False False 7.5595703125 0.096257452000026 590.418198079286 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 1 1304 8641 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999884286044897 0.999355453609522 0.999997070380594 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.169780881859315 Inf 0.131208526040619 85 1774 False False 0 0 0 0 0 0 0 6.62653374233128 0.0843535983905244 517.917818294861 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1857G>A rrl_n.1857G>A 2 non_coding_transcript_exon_variant 1475514 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1805 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1239 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1859T>C rrl_n.1859T>C 2 non_coding_transcript_exon_variant 1475516 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1861A>G rrl_n.1861A>G 2 non_coding_transcript_exon_variant 1475518 1 1 0 1 0 10 2049 15473 0 0 0.00179871197794837 0.999354130336498 0.998812544515655 0.999690238326549 0 0 0.30849710781876 0 0 0.975 0 0 0.30849710781876 0 0 293.182445928411 1 194.5 2386 False False 0 0 3.37173073063401 0 0 0.00179871197794837 0.999354130336498 0.998812544515655 0.999690238326549 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 257.202999238191 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 13 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1869C>A rrl_n.1869C>A 2 non_coding_transcript_exon_variant 1475526 NA 0 0 0 0 7 2049 15476 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 2211 2386 False False 0 0 5.24430081649792 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 7 1305 8635 0 0 0.00282273611850443 0.999190002314279 0.998331811834773 0.999674278877205 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1618 1774 False False 0 0 0 0 0 0 0 0 0 4.59639609856608 0 0 0.00282273611850443 0.999190002314279 0.998331811834773 0.999674278877205 26 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1874C>T rrl_n.1874C>T 2 non_coding_transcript_exon_variant 1475531 NA 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2212 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1619 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 12 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1875A>G rrl_n.1875A>G 2 non_coding_transcript_exon_variant 1475532 NA 0 0 0 2 2 2047 15481 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.999870826067299 0.999533458063883 0.999984356054634 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2274 2386 False False 7.56277479237909 0.547801158574908 104.389914324374 0 0 0.00180046780769359 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1675 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.187C>T rrl_n.187C>T 2 non_coding_transcript_exon_variant 1473844 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2297 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1696 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 8 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1881T>A rrl_n.1881T>A 2 non_coding_transcript_exon_variant 1475538 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2275 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1676 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 14 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1882A>G rrl_n.1882A>G 2 non_coding_transcript_exon_variant 1475539 1 0 0 0 0 10 2049 15473 0 0 0.00179871197794837 0.999354130336498 0.998812544515655 0.999690238326549 0 0 0.30849710781876 NA NA NA 0 0 0.30849710781876 NA NA NA NA 2091 2386 False False 0 0 3.37173073063401 0 0 0.00179871197794837 0.999354130336498 0.998812544515655 0.999690238326549 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1506 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 33 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1882A>T rrl_n.1882A>T 2 non_coding_transcript_exon_variant 1475539 NA 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1984 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1405 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 18 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1885A>G rrl_n.1885A>G 2 non_coding_transcript_exon_variant 1475542 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2334 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1729 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1887A>T rrl_n.1887A>T 2 non_coding_transcript_exon_variant 1475544 NA 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1985 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1406 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 8 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1888T>G rrl_n.1888T>G 2 non_coding_transcript_exon_variant 1475545 NA 0 0 0 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 2046 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 5 1305 8637 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1465 1774 False False 0 0 0 0 0 0 0 0 0 7.23014561016525 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 21 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1893A>C rrl_n.1893A>C 2 non_coding_transcript_exon_variant 1475550 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2005 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1423 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1893A>G rrl_n.1893A>G 2 non_coding_transcript_exon_variant 1475550 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1856 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1287 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 10 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.-18C>T rrl_n.-18C>T 2 upstream_gene_variant 1473640 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1914A>T rrl_n.1914A>T 2 non_coding_transcript_exon_variant 1475571 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2276 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1677 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1916G>A rrl_n.1916G>A 2 non_coding_transcript_exon_variant 1475573 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2335 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1730 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1917C>A rrl_n.1917C>A 2 non_coding_transcript_exon_variant 1475574 NA 0 0 0 3 16 2046 15467 0.00146412884333821 0.000302040401839334 0.00427278776332334 0.998966608538396 0.99832237803854 0.999409215770894 0.157894736842105 0.0338262490017646 0.395784551266674 NA NA NA 0 0 0.205907214207822 NA NA NA NA 1742 2386 False False 1.41743035190615 0.264433828913631 4.95849948719361 0 0 0.00180134700867096 0.998966608538396 0.99832237803854 0.999409215770894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 13 1303 8629 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.998495718583661 0.997429006709305 0.999198798037271 0.133333333333333 0.0165759134400836 0.404602696603372 NA NA NA 0 0 0.24705263800047 NA NA NA NA 1177 1774 False False 0 0 0 0 0 0 0 1.01883228053604 0.111491999302043 4.50815235822369 0 0 0.00282706266083767 0.998495718583661 0.997429006709305 0.999198798037271 106 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1918C>G rrl_n.1918C>G 2 non_coding_transcript_exon_variant 1475575 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1919C>T rrl_n.1919C>T 2 non_coding_transcript_exon_variant 1475576 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2115 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1921C>T rrl_n.1921C>T 2 non_coding_transcript_exon_variant 1475578 NA 0 0 0 2 0 2047 15483 0.000976085895558809 0.000118230396782607 0.00352146535805941 1 0.999761774846946 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2092 2386 False False Inf 1.41952099860885 Inf 0 0 0.00180046780769359 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 1303 8642 0.00153256704980842 0.000185654897205815 0.00552508794778556 1 0.999573236258028 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1507 1774 False False 0 0 0 0 0 0 0 Inf 1.24419098853007 Inf 0 0 0.00282706266083767 1 0.999573236258028 1 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1924A>G rrl_n.1924A>G 2 non_coding_transcript_exon_variant 1475581 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 12 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1940G>A rrl_n.1940G>A 2 non_coding_transcript_exon_variant 1475597 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1941G>A rrl_n.1941G>A 2 non_coding_transcript_exon_variant 1475598 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1918 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1945G>C rrl_n.1945G>C 2 non_coding_transcript_exon_variant 1475602 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2023 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1441 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1946G>T rrl_n.1946G>T 2 non_coding_transcript_exon_variant 1475603 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1713 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1147 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1947A>C rrl_n.1947A>C 2 non_coding_transcript_exon_variant 1475604 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1714 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1148 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1948A>G rrl_n.1948A>G 2 non_coding_transcript_exon_variant 1475605 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1961 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1949T>C rrl_n.1949T>C 2 non_coding_transcript_exon_variant 1475606 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1743 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1178 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.194G>C rrl_n.194G>C 2 non_coding_transcript_exon_variant 1473851 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1715 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1149 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 7 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1950A>G rrl_n.1950A>G 2 non_coding_transcript_exon_variant 1475607 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1744 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1179 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1951T>C rrl_n.1951T>C 2 non_coding_transcript_exon_variant 1475608 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2024 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1442 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1955G>C rrl_n.1955G>C 2 non_coding_transcript_exon_variant 1475612 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1827 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1259 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1960C>T rrl_n.1960C>T 2 non_coding_transcript_exon_variant 1475617 1 0 0 0 2 4 2047 15479 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.999741652134599 0.999338660174897 0.999929604559257 0.333333333333333 0.0432718682927417 0.777221904496487 NA NA NA 0 0 0.602364635616474 NA NA NA NA 2234 2386 False False 3.78089887640449 0.34177049769748 26.3922030252896 0 0 0.00180046780769359 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 4 1303 8638 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.999537144179588 0.998815333169806 0.999873873427139 0.333333333333333 0.0432718682927417 0.777221904496487 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1639 1774 False False 0 0 0 0 0 0 0 3.31465848042977 0.299500870485947 23.1496879983142 0 0 0.00282706266083767 0.999537144179588 0.998815333169806 0.999873873427139 13 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1964T>C rrl_n.1964T>C 2 non_coding_transcript_exon_variant 1475621 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2336 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1731 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1968delG rrl_n.1968delG 2 non_coding_transcript_exon_variant 1475623 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1891 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1972_1973insC rrl_n.1972_1973insC 2 non_coding_transcript_exon_variant 1475629 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2116 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1529 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1973dupA rrl_n.1973dupA 2 non_coding_transcript_exon_variant 1475629 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2047 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1466 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1979A>G rrl_n.1979A>G 2 non_coding_transcript_exon_variant 1475636 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1980T>G rrl_n.1980T>G 2 non_coding_transcript_exon_variant 1475637 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2255 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1658 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1981C>G rrl_n.1981C>G 2 non_coding_transcript_exon_variant 1475638 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2117 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1530 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1982C>G rrl_n.1982C>G 2 non_coding_transcript_exon_variant 1475639 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1693 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1129 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1992A>G rrl_n.1992A>G 2 non_coding_transcript_exon_variant 1475649 NA 0 0 0 0 6 2049 15477 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 2093 2386 False False 0 0 6.41986758323506 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 6 1305 8636 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1508 1774 False False 0 0 0 0 0 0 0 0 0 5.62683462374212 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 5 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1998T>A rrl_n.1998T>A 2 non_coding_transcript_exon_variant 1475655 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2118 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1531 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1998T>C rrl_n.1998T>C 2 non_coding_transcript_exon_variant 1475655 NA 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1806 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1240 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.1998T>G rrl_n.1998T>G 2 non_coding_transcript_exon_variant 1475655 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1892 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1318 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.19G>A rrl_n.19G>A 2 non_coding_transcript_exon_variant 1473676 1 1 0 1 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 293.33332543886 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2002G>A rrl_n.2002G>A 2 non_coding_transcript_exon_variant 1475659 NA 0 0 0 0 8 2049 15475 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 2164 2386 False False 0 0 4.42794679154129 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 8 1305 8634 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1573 1774 False False 0 0 0 0 0 0 0 0 0 3.88085962593317 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 6 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2010G>A rrl_n.2010G>A 2 non_coding_transcript_exon_variant 1475667 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2144 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2015C>G rrl_n.2015C>G 2 non_coding_transcript_exon_variant 1475672 NA 0 0 0 1 6 2048 15477 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999612478201898 0.999156720468893 0.999857773477374 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA 0 0 0.4592581264399 NA NA NA NA 2235 2386 False False 1.259521484375 0.0273691036001646 10.3895811388841 0 0 0.00179958946453767 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 5 1305 8637 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1640 1774 False False 0 0 0 0 0 0 0 0 0 7.23014561016525 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 9 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2015C>T rrl_n.2015C>T 2 non_coding_transcript_exon_variant 1475672 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1673 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1112 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 12 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2016T>C rrl_n.2016T>C 2 non_coding_transcript_exon_variant 1475673 NA 0 0 0 1 7 2048 15476 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999547891235548 0.999068706427379 0.999818210125054 0.125 0.0031597235312519 0.526509670875206 NA NA NA 0 0 0.409616397225003 NA NA NA NA 2277 2386 False False 1.07952008928571 0.02394099779516 8.40970244475376 0 0 0.00179958946453767 0.999547891235548 0.999068706427379 0.999818210125054 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 6 1305 8636 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1678 1774 False False 0 0 0 0 0 0 0 0 0 5.62683462374212 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 22 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2022C>T rrl_n.2022C>T 2 non_coding_transcript_exon_variant 1475679 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1674 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2029C>T rrl_n.2029C>T 2 non_coding_transcript_exon_variant 1475686 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2030C>A rrl_n.2030C>A 2 non_coding_transcript_exon_variant 1475687 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2030C>T rrl_n.2030C>T 2 non_coding_transcript_exon_variant 1475687 1 3 0 3 1 10 2048 15473 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999354130336498 0.998812544515655 0.999690238326549 0.0909090909090909 0.00229897221381426 0.412779916988382 0 0 0.707598226178713 0 0 0.30849710781876 0 0 18.2986903913059 1 619.5 2386 False False 0.755517578125 0.0174007262411499 5.31531885538471 0 0 0.00179958946453767 0.999354130336498 0.998812544515655 0.999690238326549 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 8 1305 8634 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 0 0 0.369416647552819 0 0 0.841886116991581 0 0 0.369416647552819 0 0 35.2443582517762 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 3.88085962593317 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 21 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2031G>C rrl_n.2031G>C 2 non_coding_transcript_exon_variant 1475688 NA 0 0 0 1 4 2048 15479 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999741652134599 0.999338660174897 0.999929604559257 0.2 0.00505076337946806 0.716417936118089 NA NA NA 0 0 0.602364635616474 NA NA NA NA 2236 2386 False False 1.8895263671875 0.0383494517213545 19.1050373764475 0 0 0.00179958946453767 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1641 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 10 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2039T>A rrl_n.2039T>A 2 non_coding_transcript_exon_variant 1475696 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2094 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1509 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2039T>C rrl_n.2039T>C 2 non_coding_transcript_exon_variant 1475696 NA 0 0 0 1 10 2048 15473 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999354130336498 0.998812544515655 0.999690238326549 0.0909090909090909 0.00229897221381426 0.412779916988382 NA NA NA 0 0 0.30849710781876 NA NA NA NA 1675 2386 False False 0.755517578125 0.0174007262411499 5.31531885538471 0 0 0.00179958946453767 0.999354130336498 0.998812544515655 0.999690238326549 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 9 1305 8633 0 0 0.00282273611850443 0.998958574404073 0.998023974495813 0.999523686828456 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1113 1774 False False 0 0 0 0 0 0 0 0 0 3.35590194387839 0 0 0.00282273611850443 0.998958574404073 0.998023974495813 0.999523686828456 20 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2040C>A rrl_n.2040C>A 2 non_coding_transcript_exon_variant 1475697 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2256 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1659 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2040C>T rrl_n.2040C>T 2 non_coding_transcript_exon_variant 1475697 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2042C>T rrl_n.2042C>T 2 non_coding_transcript_exon_variant 1475699 NA 0 0 0 0 7 2049 15476 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1767 2386 False False 0 0 5.24430081649792 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 7 1305 8635 0 0 0.00282273611850443 0.999190002314279 0.998331811834773 0.999674278877205 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1202 1774 False False 0 0 0 0 0 0 0 0 0 4.59639609856608 0 0 0.00282273611850443 0.999190002314279 0.998331811834773 0.999674278877205 28 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2045G>T rrl_n.2045G>T 2 non_coding_transcript_exon_variant 1475702 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1919 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1344 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2046A>G rrl_n.2046A>G 2 non_coding_transcript_exon_variant 1475703 NA 0 0 0 2 10 2047 15473 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.999354130336498 0.998812544515655 0.999690238326549 0.166666666666666 0.0208625254600923 0.484137748685967 NA NA NA 0 0 0.30849710781876 NA NA NA NA 1893 2386 False False 1.51177332681973 0.160920229387323 7.10098638741896 0 0 0.00180046780769359 0.999354130336498 0.998812544515655 0.999690238326549 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 9 1304 8633 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.998958574404073 0.998023974495813 0.999523686828456 0.1 0.00252857854446178 0.445016117028195 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1319 1774 False False 0 0 0 0 0 0 0 0.735599863667348 0.0167698879909291 5.31583775548636 0 0 0.00282489773306727 0.998958574404073 0.998023974495813 0.999523686828456 19 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2046A>T rrl_n.2046A>T 2 non_coding_transcript_exon_variant 1475703 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1920 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1345 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 5 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2050T>A rrl_n.2050T>A 2 non_coding_transcript_exon_variant 1475707 NA 0 0 0 2 7 2047 15476 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.999547891235548 0.999068706427379 0.999818210125054 0.222222222222222 0.0281449734778982 0.600093573716312 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1745 2386 False False 2.16009491241538 0.218788540583066 11.351113176461 0 0 0.00180046780769359 0.999547891235548 0.999068706427379 0.999818210125054 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 6 1304 8636 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999305716269382 0.998489453757575 0.999745168847445 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1180 1774 False False 0 0 0 0 0 0 0 1.10378323108384 0.0239783465953148 9.10896322125085 0 0 0.00282489773306727 0.999305716269382 0.998489453757575 0.999745168847445 15 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2050T>C rrl_n.2050T>C 2 non_coding_transcript_exon_variant 1475707 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2056C>G rrl_n.2056C>G 2 non_coding_transcript_exon_variant 1475713 NA 0 0 0 3 8 2046 15475 0.00146412884333821 0.000302040401839334 0.00427278776332334 0.999483304269198 0.998982158652985 0.999776901906193 0.272727272727272 0.0602177341729066 0.609742559572421 NA NA NA 0 0 0.369416647552819 NA NA NA NA 2298 2386 False False 2.83632697947214 0.484217631242897 11.8242263228461 0 0 0.00180134700867096 0.999483304269198 0.998982158652985 0.999776901906193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 6 1303 8636 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.999305716269382 0.998489453757575 0.999745168847445 0.25 0.0318540262499442 0.650855794412824 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1697 1774 False False 0 0 0 0 0 0 0 2.20926068048094 0.217820912027644 12.3689513993417 0 0 0.00282706266083767 0.999305716269382 0.998489453757575 0.999745168847445 42 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2059A>G rrl_n.2059A>G 2 non_coding_transcript_exon_variant 1475716 NA 0 0 0 3 11 2046 15472 0.00146412884333821 0.000302040401839334 0.00427278776332334 0.999289543370148 0.998729153244051 0.999645290955256 0.214285714285714 0.0465792878898673 0.507975677048471 NA NA NA 0 0 0.284914152918154 NA NA NA NA 2237 2386 False False 2.06238336443615 0.369123151192947 7.81548741330829 0 0 0.00180134700867096 0.999289543370148 0.998729153244051 0.999645290955256 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 9 1303 8633 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.998958574404073 0.998023974495813 0.999523686828456 0.181818181818181 0.0228311982999596 0.517755852360172 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1642 1774 False False 0 0 0 0 0 0 0 1.47232881384838 0.154604541408076 7.12417170347034 0 0 0.00282706266083767 0.998958574404073 0.998023974495813 0.999523686828456 47 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.205C>A rrl_n.205C>A 2 non_coding_transcript_exon_variant 1473862 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2095 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1510 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 25 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2064C>T rrl_n.2064C>T 2 non_coding_transcript_exon_variant 1475721 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2337 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 12 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2065G>A rrl_n.2065G>A 2 non_coding_transcript_exon_variant 1475722 NA 0 0 0 2 1 2047 15482 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.99993541303365 0.999640197578315 0.999998364800924 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 1694 2386 False False 15.1265266243282 0.786906901669143 886.86117101553 0 0 0.00180046780769359 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 1 1303 8641 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.999884286044897 0.999355453609522 0.999997070380594 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 1130 1774 False False 0 0 0 0 0 0 0 13.2632386799693 0.689686563300777 778.308617525017 0 0 0.00282706266083767 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2078T>C rrl_n.2078T>C 2 non_coding_transcript_exon_variant 1475735 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1872 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1303 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2083G>C rrl_n.2083G>C 2 non_coding_transcript_exon_variant 1475740 NA 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1857 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1288 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2090A>G rrl_n.2090A>G 2 non_coding_transcript_exon_variant 1475747 NA 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1768 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1203 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 5 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2093A>C rrl_n.2093A>C 2 non_coding_transcript_exon_variant 1475750 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2213 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1620 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 7 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2093A>G rrl_n.2093A>G 2 non_coding_transcript_exon_variant 1475750 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2094C>G rrl_n.2094C>G 2 non_coding_transcript_exon_variant 1475751 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1894 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1320 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2095C>T rrl_n.2095C>T 2 non_coding_transcript_exon_variant 1475752 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2096C>G rrl_n.2096C>G 2 non_coding_transcript_exon_variant 1475753 NA 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1941 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1365 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 13 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2096C>T rrl_n.2096C>T 2 non_coding_transcript_exon_variant 1475753 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2006 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1424 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2097G>C rrl_n.2097G>C 2 non_coding_transcript_exon_variant 1475754 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1895 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1321 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2101_2112delACCCGCAAGGGTinsGCGTAAGC rrl_n.2101_2112delACCCGCAAGGGTinsGCGTAAGC 2 non_coding_transcript_exon_variant 1475758 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2214 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1621 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2101_2112delACCCGCAAGGGTinsGCTGGCTTTCGGGCCGGC rrl_n.2101_2112delACCCGCAAGGGTinsGCTGGCTTTCGGGCCGGC 2 non_coding_transcript_exon_variant 1475758 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2025 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1443 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2105_2108delGCAAinsTT rrl_n.2105_2108delGCAAinsTT 2 non_coding_transcript_exon_variant 1475762 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2119 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1532 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2105G>A rrl_n.2105G>A 2 non_coding_transcript_exon_variant 1475762 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2105G>T rrl_n.2105G>T 2 non_coding_transcript_exon_variant 1475762 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1676 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1114 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2106C>T rrl_n.2106C>T 2 non_coding_transcript_exon_variant 1475763 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2066 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1483 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2107A>C rrl_n.2107A>C 2 non_coding_transcript_exon_variant 1475764 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2355 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1749 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2108A>G rrl_n.2108A>G 2 non_coding_transcript_exon_variant 1475765 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1873 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1304 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2111G>T rrl_n.2111G>T 2 non_coding_transcript_exon_variant 1475768 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 35.2688392655279 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2115A>C rrl_n.2115A>C 2 non_coding_transcript_exon_variant 1475772 NA 0 0 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1746 2386 False False Inf 0.193753017505121 Inf 0 0 0.00179958946453767 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1181 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0 0 0.00282489773306727 1 0.999573236258028 1 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2115A>T rrl_n.2115A>T 2 non_coding_transcript_exon_variant 1475772 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2117C>G rrl_n.2117C>G 2 non_coding_transcript_exon_variant 1475774 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2356 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1750 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2118G>A rrl_n.2118G>A 2 non_coding_transcript_exon_variant 1475775 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2278 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1679 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2118G>T rrl_n.2118G>T 2 non_coding_transcript_exon_variant 1475775 NA 0 0 0 0 7 2049 15476 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 2145 2386 False False 0 0 5.24430081649792 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 7 1305 8635 0 0 0.00282273611850443 0.999190002314279 0.998331811834773 0.999674278877205 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1555 1774 False False 0 0 0 0 0 0 0 0 0 4.59639609856608 0 0 0.00282273611850443 0.999190002314279 0.998331811834773 0.999674278877205 17 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.211C>T rrl_n.211C>T 2 non_coding_transcript_exon_variant 1473868 1 3 1 2 1 2 2048 15481 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999870826067299 0.999533458063883 0.999984356054634 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 3.779541015625 0.0640320806562028 72.4657839845296 0.311250780471001 136 2386 False False 3.779541015625 0.0640320806562028 72.4657839845296 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 14 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2120A>C rrl_n.2120A>C 2 non_coding_transcript_exon_variant 1475777 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1858 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1289 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2123A>G rrl_n.2123A>G 2 non_coding_transcript_exon_variant 1475780 1 1 0 1 1 1 2048 15482 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.99993541303365 0.999640197578315 0.999998364800924 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 293.494766828651 1 194.5 2386 False False 7.5595703125 0.096257452000026 590.418198079286 0 0 0.00179958946453767 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 5 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2124T>C rrl_n.2124T>C 2 non_coding_transcript_exon_variant 1475781 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2096 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1511 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 5 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2126T>G rrl_n.2126T>G 2 non_coding_transcript_exon_variant 1475783 NA 0 0 0 1 5 2048 15478 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999677065168249 0.999246540104889 0.9998951358908 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA 0 0 0.521823750104981 NA NA NA NA 2026 2386 False False 1.5115234375 0.0319423199882685 13.5174010142692 0 0 0.00179958946453767 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 4 1304 8638 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999537144179588 0.998815333169806 0.999873873427139 0.2 0.00505076337946806 0.716417936118089 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1444 1774 False False 0 0 0 0 0 0 0 1.65605828220858 0.0336017769800931 16.7446524584225 0 0 0.00282489773306727 0.999537144179588 0.998815333169806 0.999873873427139 40 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.212C>T rrl_n.212C>T 2 non_coding_transcript_exon_variant 1473869 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2131C>G rrl_n.2131C>G 2 non_coding_transcript_exon_variant 1475788 NA 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2279 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1680 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2134A>G rrl_n.2134A>G 2 non_coding_transcript_exon_variant 1475791 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1716 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1150 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.213G>A rrl_n.213G>A 2 non_coding_transcript_exon_variant 1473870 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1677 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1115 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 6 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.213G>T rrl_n.213G>T 2 non_coding_transcript_exon_variant 1473870 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2165 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1574 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2146T>C rrl_n.2146T>C 2 non_coding_transcript_exon_variant 1475803 NA 0 0 0 2 14 2047 15469 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.999095782471097 0.998483341560662 0.999505570487652 0.125 0.0155136038154138 0.383476236849263 NA NA NA 0 0 0.231635761650116 NA NA NA NA 2146 2386 False False 1.07955893642263 0.118984769392524 4.70616521734574 0 0 0.00180046780769359 0.999095782471097 0.998483341560662 0.999505570487652 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 12 1304 8630 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.998611432538764 0.997575709681241 0.999282307587457 0.0769230769230769 0.00194562849734675 0.360297435267877 NA NA NA 0 0 0.264648469397051 NA NA NA NA 1556 1774 False False 0 0 0 0 0 0 0 0.5515081799591 0.0128948370956567 3.73372301913507 0 0 0.00282489773306727 0.998611432538764 0.997575709681241 0.999282307587457 97 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2147G>C rrl_n.2147G>C 2 non_coding_transcript_exon_variant 1475804 NA 0 0 0 2 14 2047 15469 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.999095782471097 0.998483341560662 0.999505570487652 0.125 0.0155136038154138 0.383476236849263 NA NA NA 0 0 0.231635761650116 NA NA NA NA 1921 2386 False False 1.07955893642263 0.118984769392524 4.70616521734574 0 0 0.00180046780769359 0.999095782471097 0.998483341560662 0.999505570487652 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 12 1304 8630 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.998611432538764 0.997575709681241 0.999282307587457 0.0769230769230769 0.00194562849734675 0.360297435267877 NA NA NA 0 0 0.264648469397051 NA NA NA NA 1346 1774 False False 0 0 0 0 0 0 0 0.5515081799591 0.0128948370956567 3.73372301913507 0 0 0.00282489773306727 0.998611432538764 0.997575709681241 0.999282307587457 97 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.214T>C rrl_n.214T>C 2 non_coding_transcript_exon_variant 1473871 NA 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2318 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1715 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 15 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.214T>G rrl_n.214T>G 2 non_coding_transcript_exon_variant 1473871 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1962 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1384 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 25 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2152C>T rrl_n.2152C>T 2 non_coding_transcript_exon_variant 1475809 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2152dupC rrl_n.2152dupC 2 non_coding_transcript_exon_variant 1475808 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.169800530161289 Inf 0.131195335276967 59 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2159C>G rrl_n.2159C>G 2 non_coding_transcript_exon_variant 1475816 NA 0 0 0 3 14 2046 15469 0.00146412884333821 0.000302040401839334 0.00427278776332334 0.999095782471097 0.998483341560662 0.999505570487652 0.176470588235294 0.0379850680706259 0.434317872844283 NA NA NA 0 0 0.231635761650116 NA NA NA NA 1678 2386 False False 1.62012987012987 0.298292433443589 5.81217329995604 0 0 0.00180134700867096 0.999095782471097 0.998483341560662 0.999505570487652 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 13 1303 8629 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.998495718583661 0.997429006709305 0.999198798037271 0.133333333333333 0.0165759134400836 0.404602696603372 NA NA NA 0 0 0.24705263800047 NA NA NA NA 1116 1774 False False 0 0 0 0 0 0 0 1.01883228053604 0.111491999302043 4.50815235822369 0 0 0.00282706266083767 0.998495718583661 0.997429006709305 0.999198798037271 122 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2160A>G rrl_n.2160A>G 2 non_coding_transcript_exon_variant 1475817 NA 0 0 0 3 14 2046 15469 0.00146412884333821 0.000302040401839334 0.00427278776332334 0.999095782471097 0.998483341560662 0.999505570487652 0.176470588235294 0.0379850680706259 0.434317872844283 NA NA NA 0 0 0.231635761650116 NA NA NA NA 1942 2386 False False 1.62012987012987 0.298292433443589 5.81217329995604 0 0 0.00180134700867096 0.999095782471097 0.998483341560662 0.999505570487652 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 13 1303 8629 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.998495718583661 0.997429006709305 0.999198798037271 0.133333333333333 0.0165759134400836 0.404602696603372 NA NA NA 0 0 0.24705263800047 NA NA NA NA 1366 1774 False False 0 0 0 0 0 0 0 1.01883228053604 0.111491999302043 4.50815235822369 0 0 0.00282706266083767 0.998495718583661 0.997429006709305 0.999198798037271 122 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2180C>T rrl_n.2180C>T 2 non_coding_transcript_exon_variant 1475837 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2186G>A rrl_n.2186G>A 2 non_coding_transcript_exon_variant 1475843 NA 0 0 0 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1922 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1347 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 6 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2192G>A rrl_n.2192G>A 2 non_coding_transcript_exon_variant 1475849 NA 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 2147 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1557 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 6 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2196C>T rrl_n.2196C>T 2 non_coding_transcript_exon_variant 1475853 NA 0 0 0 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1695 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1131 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 6 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.219G>A rrl_n.219G>A 2 non_coding_transcript_exon_variant 1473876 NA 0 0 0 0 9 2049 15474 0 0 0.00179871197794837 0.999418717302848 0.998896832459985 0.999734167184357 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 2120 2386 False False 0 0 3.82923083971975 0 0 0.00179871197794837 0.999418717302848 0.998896832459985 0.999734167184357 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 8 1305 8634 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1533 1774 False False 0 0 0 0 0 0 0 0 0 3.88085962593317 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 46 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.-21A>G rrl_n.-21A>G 2 upstream_gene_variant 1473637 1 9 0 9 1 11 2048 15472 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999289543370148 0.998729153244051 0.999645290955256 0.0833333333333333 0.00210759323186022 0.384796165150944 0 0 0.336267116879942 0 0 0.284914152918154 0 0 3.83060707416017 0.610724807780288 169 2386 False False 0.686789772727272 0.0159480966540523 4.72976907145362 0 0 0.00179958946453767 0.999289543370148 0.998729153244051 0.999645290955256 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2201T>C rrl_n.2201T>C 2 non_coding_transcript_exon_variant 1475858 NA 0 0 0 3 14 2046 15469 0.00146412884333821 0.000302040401839334 0.00427278776332334 0.999095782471097 0.998483341560662 0.999505570487652 0.176470588235294 0.0379850680706259 0.434317872844283 NA NA NA 0 0 0.231635761650116 NA NA NA NA 2148 2386 False False 1.62012987012987 0.298292433443589 5.81217329995604 0 0 0.00180134700867096 0.999095782471097 0.998483341560662 0.999505570487652 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 13 1303 8629 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.998495718583661 0.997429006709305 0.999198798037271 0.133333333333333 0.0165759134400836 0.404602696603372 NA NA NA 0 0 0.24705263800047 NA NA NA NA 1558 1774 False False 0 0 0 0 0 0 0 1.01883228053604 0.111491999302043 4.50815235822369 0 0 0.00282706266083767 0.998495718583661 0.997429006709305 0.999198798037271 102 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2209T>A rrl_n.2209T>A 2 non_coding_transcript_exon_variant 1475866 NA 0 0 0 2 9 2047 15474 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.999418717302848 0.998896832459985 0.999734167184357 0.181818181818181 0.0228311982999596 0.517755852360172 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1679 2386 False False 1.67985670086305 0.176481355552764 8.12348790592676 0 0 0.00180046780769359 0.999418717302848 0.998896832459985 0.999734167184357 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 8 1304 8634 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999074288359176 0.998176798225858 0.999600261389848 0.111111111111111 0.00280913674659921 0.482496514917337 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1117 1774 False False 0 0 0 0 0 0 0 0.827645705521472 0.0186379987589414 6.18187193560828 0 0 0.00282489773306727 0.999074288359176 0.998176798225858 0.999600261389848 90 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2209T>G rrl_n.2209T>G 2 non_coding_transcript_exon_variant 1475866 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2212C>T rrl_n.2212C>T 2 non_coding_transcript_exon_variant 1475869 NA 0 0 0 1 2 2048 15481 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999870826067299 0.999533458063883 0.999984356054634 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2238 2386 False False 3.779541015625 0.0640320806562028 72.4657839845296 0 0 0.00179958946453767 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 2 1304 8640 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999768572089794 0.999164255486522 0.999971971777513 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1643 1774 False False 0 0 0 0 0 0 0 3.31288343558282 0.056110603773561 63.7302235362974 0 0 0.00282489773306727 0.999768572089794 0.999164255486522 0.999971971777513 8 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2214T>C rrl_n.2214T>C 2 non_coding_transcript_exon_variant 1475871 NA 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2239 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1644 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2220C>T rrl_n.2220C>T 2 non_coding_transcript_exon_variant 1475877 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2338 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1732 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 5 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2223C>G rrl_n.2223C>G 2 non_coding_transcript_exon_variant 1475880 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2149 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1559 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2224T>G rrl_n.2224T>G 2 non_coding_transcript_exon_variant 1475881 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2319 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1716 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2225C>G rrl_n.2225C>G 2 non_coding_transcript_exon_variant 1475882 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1784 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1217 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2226A>C rrl_n.2226A>C 2 non_coding_transcript_exon_variant 1475883 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2357 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1751 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 24 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2226A>G rrl_n.2226A>G 2 non_coding_transcript_exon_variant 1475883 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2299 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1698 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2226A>T rrl_n.2226A>T 2 non_coding_transcript_exon_variant 1475883 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2280 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1681 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 20 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2227A>G rrl_n.2227A>G 2 non_coding_transcript_exon_variant 1475884 1 1 0 1 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 293.33332543886 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 257.202999238191 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 24 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2240T>C rrl_n.2240T>C 2 non_coding_transcript_exon_variant 1475897 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2300 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1699 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 16 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2240T>G rrl_n.2240T>G 2 non_coding_transcript_exon_variant 1475897 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2358 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1752 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2241A>G rrl_n.2241A>G 2 non_coding_transcript_exon_variant 1475898 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1696 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1132 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 26 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2242G>A rrl_n.2242G>A 2 non_coding_transcript_exon_variant 1475899 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2007 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1425 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 33 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2243A>G rrl_n.2243A>G 2 non_coding_transcript_exon_variant 1475900 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2189 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1597 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 16 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2245T>C rrl_n.2245T>C 2 non_coding_transcript_exon_variant 1475902 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2067 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1484 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 8 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2249C>T rrl_n.2249C>T 2 non_coding_transcript_exon_variant 1475906 1 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 2257 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1660 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 12 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2259C>G rrl_n.2259C>G 2 non_coding_transcript_exon_variant 1475916 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1697 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1133 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 38 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2259C>T rrl_n.2259C>T 2 non_coding_transcript_exon_variant 1475916 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1698 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1134 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 10 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2262C>A rrl_n.2262C>A 2 non_coding_transcript_exon_variant 1475919 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2068 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1485 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2269_2270insT rrl_n.2269_2270insT 2 non_coding_transcript_exon_variant 1475926 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2281 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2270G>T rrl_n.2270G>T 2 non_coding_transcript_exon_variant 1475927 1 2 0 2 5 5 2044 15478 0.00244021473889702 0.000792791037816739 0.00568538572188254 0.999677065168249 0.999246540104889 0.9998951358908 0.5 0.187086028447398 0.812913971552601 0 0 0.841886116991581 0 0 0.521823750104981 0 0 40.3272782515878 1 619.5 2386 False False 7.57240704500978 1.74070230834698 32.9298484643654 0 0 0.00180310798912163 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 1303 8641 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.999884286044897 0.999355453609522 0.999997070380594 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 257.625887049255 1 503.5 1774 False False 0 0 0 0 0 0 0 13.2632386799693 0.689686563300777 778.308617525017 0 0 0.00282706266083767 0.999884286044897 0.999355453609522 0.999997070380594 17 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2280A>T rrl_n.2280A>T 2 non_coding_transcript_exon_variant 1475937 NA 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1874 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1305 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 17 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2281C>T rrl_n.2281C>T 2 non_coding_transcript_exon_variant 1475938 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2286G>A rrl_n.2286G>A 2 non_coding_transcript_exon_variant 1475943 NA 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 2215 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1622 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 34 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.228A>G rrl_n.228A>G 2 non_coding_transcript_exon_variant 1473885 1 3 0 3 1 3 2048 15480 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999806239100949 0.999433853882399 0.999960040061829 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 18.30693542144 1 619.5 2386 False False 2.51953125 0.047970285762596 31.379124977949 0 0 0.00179958946453767 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 3 1304 8639 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999652858134691 0.998985842622235 0.999928405279598 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 16.0442452167038 1 503.5 1774 False False 0 0 0 0 0 0 0 2.20833333333333 0.0420336930075031 27.526218938507 0 0 0.00282489773306727 0.999652858134691 0.998985842622235 0.999928405279598 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2292A>G rrl_n.2292A>G 2 non_coding_transcript_exon_variant 1475949 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1923 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1348 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2294G>A rrl_n.2294G>A 2 non_coding_transcript_exon_variant 1475951 1 2 1 1 8 1 2041 15482 0.00390434358223523 0.00168707939779644 0.00767854500622988 0.99993541303365 0.999640197578315 0.999998364800924 0.888888888888888 0.517503485082663 0.9971908632534 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 7.58549730524252 0.0965874248717988 592.432068148169 0.219467653246527 112 2386 False False 60.6839784419402 8.1256809532182 2650.77965033639 0.00048971596474045 1.23984579006255e-05 0.00272547035985628 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 8 1 1297 8641 0.00613026819923371 0.00265021962516072 0.0120431650220116 0.999884286044897 0.999355453609522 0.999997070380594 0.888888888888888 0.517503485082663 0.9971908632534 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 6.66229760986892 0.0848085124694273 520.699711392701 0.244126374101334 89 1774 False False 0 0 0 0 0 0 0 53.2983808789514 7.13105490147475 2333.39311355 0.000770416024653312 1.95050547541384e-05 0.00428493176978959 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2294G>T rrl_n.2294G>T 2 non_coding_transcript_exon_variant 1475951 NA 0 0 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1924 2386 False False Inf 0.193753017505121 Inf 0 0 0.00179958946453767 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1349 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0 0 0.00282489773306727 1 0.999573236258028 1 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2295A>C rrl_n.2295A>C 2 non_coding_transcript_exon_variant 1475952 1 0 0 0 2 3 2047 15480 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.999806239100949 0.999433853882399 0.999960040061829 0.4 0.0527449505263169 0.853367200365326 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1699 2386 False False 5.04152418172936 0.420787897776746 44.0540252618051 0 0 0.00180046780769359 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 1304 8641 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999884286044897 0.999355453609522 0.999997070380594 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1135 1774 False False 0 0 0 0 0 0 0 6.62653374233128 0.0843535983905244 517.917818294861 0 0 0.00282489773306727 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2295A>G rrl_n.2295A>G 2 non_coding_transcript_exon_variant 1475952 NA 0 0 0 0 6 2049 15477 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1943 2386 False False 0 0 6.41986758323506 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 6 1305 8636 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1367 1774 False False 0 0 0 0 0 0 0 0 0 5.62683462374212 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 39 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2296A>G rrl_n.2296A>G 2 non_coding_transcript_exon_variant 1475953 1 1 0 1 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 293.33332543886 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 257.202999238191 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2297A>G rrl_n.2297A>G 2 non_coding_transcript_exon_variant 1475954 NA 0 0 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2216 2386 False False Inf 0.193753017505121 Inf 0 0 0.00179958946453767 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.22T>C rrl_n.22T>C 2 non_coding_transcript_exon_variant 1473679 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2320 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.230delTinsAA rrl_n.230delTinsAA 2 non_coding_transcript_exon_variant 1473887 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1944 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1368 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.230T>C rrl_n.230T>C 2 non_coding_transcript_exon_variant 1473887 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1807 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1241 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.230T>G rrl_n.230T>G 2 non_coding_transcript_exon_variant 1473887 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2301 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1700 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 6 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2313C>T rrl_n.2313C>T 2 non_coding_transcript_exon_variant 1475970 NA 0 0 0 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1769 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 5 1305 8637 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1204 1774 False False 0 0 0 0 0 0 0 0 0 7.23014561016525 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 28 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2314A>G rrl_n.2314A>G 2 non_coding_transcript_exon_variant 1475971 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2317A>G rrl_n.2317A>G 2 non_coding_transcript_exon_variant 1475974 1 1 0 1 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 293.33332543886 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2318C>T rrl_n.2318C>T 2 non_coding_transcript_exon_variant 1475975 NA 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2150 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1560 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 23 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.231T>A rrl_n.231T>A 2 non_coding_transcript_exon_variant 1473888 NA 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1680 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1118 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 41 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.231T>C rrl_n.231T>C 2 non_coding_transcript_exon_variant 1473888 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2121 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1534 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2320A>G rrl_n.2320A>G 2 non_coding_transcript_exon_variant 1475977 NA 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 2151 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1561 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 28 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2321C>T rrl_n.2321C>T 2 non_coding_transcript_exon_variant 1475978 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2048 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1467 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 15 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2324G>A rrl_n.2324G>A 2 non_coding_transcript_exon_variant 1475981 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2152 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1562 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2331A>G rrl_n.2331A>G 2 non_coding_transcript_exon_variant 1475988 NA 0 0 0 0 11 2049 15472 0 0 0.00179871197794837 0.999289543370148 0.998729153244051 0.999645290955256 0 0 0.284914152918154 NA NA NA 0 0 0.284914152918154 NA NA NA NA 1945 2386 False True 0 0 3.01101772028239 0 0 0.00179871197794837 0.999289543370148 0.998729153244051 0.999645290955256 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 7 1305 8635 0 0 0.00282273611850443 0.999190002314279 0.998331811834773 0.999674278877205 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1369 1774 False True 1 0 1 0 0 0 0 0 0 4.59639609856608 0 0 0.00282273611850443 0.999190002314279 0.998331811834773 0.999674278877205 34 5) Not assoc w R New NotAwR yes 5 +Capreomycin rrl n.2332T>C rrl_n.2332T>C 2 non_coding_transcript_exon_variant 1475989 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2302 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1701 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2334T>C rrl_n.2334T>C 2 non_coding_transcript_exon_variant 1475991 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2321 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1717 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2336C>T rrl_n.2336C>T 2 non_coding_transcript_exon_variant 1475993 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2069 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1486 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 12 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2338G>A rrl_n.2338G>A 2 non_coding_transcript_exon_variant 1475995 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2070 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1487 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2340A>T rrl_n.2340A>T 2 non_coding_transcript_exon_variant 1475997 NA 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1770 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1205 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 12 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2341C>A rrl_n.2341C>A 2 non_coding_transcript_exon_variant 1475998 1 1 0 1 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 293.314465539138 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 257.202999238191 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2343G>T rrl_n.2343G>T 2 non_coding_transcript_exon_variant 1476000 1 1 0 1 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 293.33332543886 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2344T>C rrl_n.2344T>C 2 non_coding_transcript_exon_variant 1476001 NA 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1747 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1182 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 14 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2350T>G rrl_n.2350T>G 2 non_coding_transcript_exon_variant 1476007 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2071 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1488 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 7 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2354A>G rrl_n.2354A>G 2 non_coding_transcript_exon_variant 1476011 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.236T>C rrl_n.236T>C 2 non_coding_transcript_exon_variant 1473893 1 1 0 1 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 293.314465539138 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 257.202999238191 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 8 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2373A>G rrl_n.2373A>G 2 non_coding_transcript_exon_variant 1476030 1 1 0 1 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 293.33332543886 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 257.202999238191 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 13 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2375C>T rrl_n.2375C>T 2 non_coding_transcript_exon_variant 1476032 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1717 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1151 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2376T>C rrl_n.2376T>C 2 non_coding_transcript_exon_variant 1476033 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2282 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1682 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2377C>A rrl_n.2377C>A 2 non_coding_transcript_exon_variant 1476034 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2049 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1468 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2377C>G rrl_n.2377C>G 2 non_coding_transcript_exon_variant 1476034 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1859 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1290 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 8 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2378G>C rrl_n.2378G>C 2 non_coding_transcript_exon_variant 1476035 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2050 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1469 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2387T>G rrl_n.2387T>G 2 non_coding_transcript_exon_variant 1476044 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2258 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1661 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2388G>T rrl_n.2388G>T 2 non_coding_transcript_exon_variant 1476045 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2122 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1535 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2392C>T rrl_n.2392C>T 2 non_coding_transcript_exon_variant 1476049 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2166 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1575 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 14 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2398C>T rrl_n.2398C>T 2 non_coding_transcript_exon_variant 1476055 1 2 0 2 1 2 2048 15481 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999870826067299 0.999533458063883 0.999984356054634 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2563859690691 1 619.5 2386 False False 3.779541015625 0.0640320806562028 72.4657839845296 0 0 0.00179958946453767 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 1304 8640 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999768572089794 0.999164255486522 0.999971971777513 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 35.2958866065447 1 503.5 1774 False False 0 0 0 0 0 0 0 3.31288343558282 0.056110603773561 63.7302235362974 0 0 0.00282489773306727 0.999768572089794 0.999164255486522 0.999971971777513 9 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2399G>A rrl_n.2399G>A 2 non_coding_transcript_exon_variant 1476056 NA 0 0 0 9 66 2040 15417 0.00439238653001464 0.00201038610804174 0.00832167289780672 0.995737260220887 0.994579898711817 0.996701709491994 0.12 0.0563662842253199 0.215613123516589 NA NA NA 0 0 0.0543588471701219 NA NA NA NA 1963 2386 False True 1.03054812834224 0.450725517205252 2.0815257361676 0 0 0.00180664029936583 0.995737260220887 0.994579898711817 0.996701709491994 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 4 38 1301 8604 0.00306513409961685 0.000835757856895071 0.00782921001204628 0.995602869706086 0.993969541437374 0.996886506176495 0.0952380952380952 0.0265635696407603 0.226224871552779 NA NA NA 0 0 0.0925127614158782 NA NA NA NA 1385 1774 False True 0 1 1 0 0 0 0 0.696144666046361 0.180188529014616 1.93825628547535 0 0 0.00283140248651778 0.995602869706086 0.993969541437374 0.996886506176495 212 5) Not assoc w R New NotAwR yes 5 +Capreomycin rrl n.2401T>C rrl_n.2401T>C 2 non_coding_transcript_exon_variant 1476058 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1718 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1152 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 6 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2414C>T rrl_n.2414C>T 2 non_coding_transcript_exon_variant 1476071 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.241C>G rrl_n.241C>G 2 non_coding_transcript_exon_variant 1473898 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1875 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1306 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.241C>T rrl_n.241C>T 2 non_coding_transcript_exon_variant 1473898 1 0 0 0 0 7 2049 15476 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1946 2386 False False 0 0 5.24430081649792 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 6 1305 8636 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1370 1774 False False 0 0 0 0 0 0 0 0 0 5.62683462374212 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 43 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2421C>A rrl_n.2421C>A 2 non_coding_transcript_exon_variant 1476078 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2428G>A rrl_n.2428G>A 2 non_coding_transcript_exon_variant 1476085 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1785 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1218 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2429G>A rrl_n.2429G>A 2 non_coding_transcript_exon_variant 1476086 NA 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2097 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1512 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.242A>C rrl_n.242A>C 2 non_coding_transcript_exon_variant 1473899 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2098 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1513 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 28 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.242A>G rrl_n.242A>G 2 non_coding_transcript_exon_variant 1473899 NA 0 0 0 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1947 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 5 1305 8637 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1371 1774 False False 0 0 0 0 0 0 0 0 0 7.23014561016525 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 9 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2431A>C rrl_n.2431A>C 2 non_coding_transcript_exon_variant 1476088 NA 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 2027 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1445 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2434T>C rrl_n.2434T>C 2 non_coding_transcript_exon_variant 1476091 1 27 4 23 9 26 2040 15457 0.00439238653001464 0.00201038610804174 0.00832167289780672 0.998320738874895 0.997540454635474 0.998902766748277 0.257142857142857 0.124893971916761 0.432558849694038 0.148148148148148 0.0418873964737672 0.337310864024244 0.133333333333333 0.0375534963383633 0.307218350276126 1.31773231031543 0.330923087907065 3.86211154055539 0.548210962900777 157 2386 False False 2.62279411764705 1.07971824967279 5.7852367611517 0.00195694716242661 0.000533451579626573 0.00500291625222746 0.998320738874895 0.997540454635474 0.998902766748277 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 26 3 23 8 26 1297 8616 0.00613026819923371 0.00265021962516072 0.0120431650220116 0.996991437167322 0.995594844195753 0.998033794414764 0.235294117647058 0.107461815775008 0.411707841907166 0.115384615384615 0.0244580753179622 0.301540400107567 0.103448275862068 0.0218637368298536 0.273515197892423 0.866481177298783 0.16630592133095 2.87406384238974 1 275.5 1774 False False 0 0 0 0 0 0 0 2.04400687978174 0.797987847545376 4.66175470809346 0.0023076923076923 0.000476154703977036 0.00672911114063734 0.996991437167322 0.995594844195753 0.998033794414764 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2442A>G rrl_n.2442A>G 2 non_coding_transcript_exon_variant 1476099 NA 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2167 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1576 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2446_2449delCTGAinsATG rrl_n.2446_2449delCTGAinsATG 2 non_coding_transcript_exon_variant 1476103 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1860 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1291 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2446C>A rrl_n.2446C>A 2 non_coding_transcript_exon_variant 1476103 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2339 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1733 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2446C>G rrl_n.2446C>G 2 non_coding_transcript_exon_variant 1476103 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1681 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1119 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2448G>A rrl_n.2448G>A 2 non_coding_transcript_exon_variant 1476105 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1861 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1292 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2449A>T rrl_n.2449A>T 2 non_coding_transcript_exon_variant 1476106 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1876 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1307 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2451T>G rrl_n.2451T>G 2 non_coding_transcript_exon_variant 1476108 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2359 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1753 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2453G>A rrl_n.2453G>A 2 non_coding_transcript_exon_variant 1476110 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2453G>C rrl_n.2453G>C 2 non_coding_transcript_exon_variant 1476110 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1771 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1206 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2453G>T rrl_n.2453G>T 2 non_coding_transcript_exon_variant 1476110 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2283 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1683 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2454G>A rrl_n.2454G>A 2 non_coding_transcript_exon_variant 1476111 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2457T>C rrl_n.2457T>C 2 non_coding_transcript_exon_variant 1476114 1 2 0 2 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 40.2341634723554 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 257.202999238191 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2458T>C rrl_n.2458T>C 2 non_coding_transcript_exon_variant 1476115 NA 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1808 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1242 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 6 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2461G>A rrl_n.2461G>A 2 non_coding_transcript_exon_variant 1476118 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2465A>T rrl_n.2465A>T 2 non_coding_transcript_exon_variant 1476122 NA 0 0 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1809 2386 False False Inf 0.193753017505121 Inf 0 0 0.00179958946453767 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2466G>T rrl_n.2466G>T 2 non_coding_transcript_exon_variant 1476123 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2322 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2467T>C rrl_n.2467T>C 2 non_coding_transcript_exon_variant 1476124 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1877 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2469C>T rrl_n.2469C>T 2 non_coding_transcript_exon_variant 1476126 NA 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 2190 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1598 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 27 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2471T>A rrl_n.2471T>A 2 non_coding_transcript_exon_variant 1476128 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1828 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1260 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2472G>A rrl_n.2472G>A 2 non_coding_transcript_exon_variant 1476129 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2473G>A rrl_n.2473G>A 2 non_coding_transcript_exon_variant 1476130 NA 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 2340 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1734 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 44 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2474C>T rrl_n.2474C>T 2 non_coding_transcript_exon_variant 1476131 NA 0 0 0 0 6 2049 15477 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1964 2386 False False 0 0 6.41986758323506 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 6 1305 8636 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1386 1774 False False 0 0 0 0 0 0 0 0 0 5.62683462374212 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 32 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2478T>C rrl_n.2478T>C 2 non_coding_transcript_exon_variant 1476135 NA 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 2051 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1470 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 43 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2484A>G rrl_n.2484A>G 2 non_coding_transcript_exon_variant 1476141 NA 0 0 0 3 14 2046 15469 0.00146412884333821 0.000302040401839334 0.00427278776332334 0.999095782471097 0.998483341560662 0.999505570487652 0.176470588235294 0.0379850680706259 0.434317872844283 NA NA NA 0 0 0.231635761650116 NA NA NA NA 1719 2386 False False 1.62012987012987 0.298292433443589 5.81217329995604 0 0 0.00180134700867096 0.999095782471097 0.998483341560662 0.999505570487652 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 13 1303 8629 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.998495718583661 0.997429006709305 0.999198798037271 0.133333333333333 0.0165759134400836 0.404602696603372 NA NA NA 0 0 0.24705263800047 NA NA NA NA 1153 1774 False False 0 0 0 0 0 0 0 1.01883228053604 0.111491999302043 4.50815235822369 0 0 0.00282706266083767 0.998495718583661 0.997429006709305 0.999198798037271 89 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.248T>C rrl_n.248T>C 2 non_coding_transcript_exon_variant 1473905 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2259 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1662 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 6 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2496T>C rrl_n.2496T>C 2 non_coding_transcript_exon_variant 1476153 NA 0 0 0 3 14 2046 15469 0.00146412884333821 0.000302040401839334 0.00427278776332334 0.999095782471097 0.998483341560662 0.999505570487652 0.176470588235294 0.0379850680706259 0.434317872844283 NA NA NA 0 0 0.231635761650116 NA NA NA NA 1925 2386 False False 1.62012987012987 0.298292433443589 5.81217329995604 0 0 0.00180134700867096 0.999095782471097 0.998483341560662 0.999505570487652 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 13 1303 8629 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.998495718583661 0.997429006709305 0.999198798037271 0.133333333333333 0.0165759134400836 0.404602696603372 NA NA NA 0 0 0.24705263800047 NA NA NA NA 1350 1774 False False 0 0 0 0 0 0 0 1.01883228053604 0.111491999302043 4.50815235822369 0 0 0.00282706266083767 0.998495718583661 0.997429006709305 0.999198798037271 90 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2503T>C rrl_n.2503T>C 2 non_coding_transcript_exon_variant 1476160 NA 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2072 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1489 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 8 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2503T>G rrl_n.2503T>G 2 non_coding_transcript_exon_variant 1476160 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2507A>G rrl_n.2507A>G 2 non_coding_transcript_exon_variant 1476164 NA 0 0 0 0 7 2049 15476 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1786 2386 False False 0 0 5.24430081649792 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 7 1305 8635 0 0 0.00282273611850443 0.999190002314279 0.998331811834773 0.999674278877205 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1219 1774 False False 0 0 0 0 0 0 0 0 0 4.59639609856608 0 0 0.00282273611850443 0.999190002314279 0.998331811834773 0.999674278877205 27 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2508T>A rrl_n.2508T>A 2 non_coding_transcript_exon_variant 1476165 NA 0 0 0 2 3 2047 15480 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.999806239100949 0.999433853882399 0.999960040061829 0.4 0.0527449505263169 0.853367200365326 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2028 2386 False False 5.04152418172936 0.420787897776746 44.0540252618051 0 0 0.00180046780769359 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 3 1303 8639 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.999652858134691 0.998985842622235 0.999928405279598 0.4 0.0527449505263169 0.853367200365326 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1446 1774 False False 0 0 0 0 0 0 0 4.42005628037861 0.368763684490018 38.622243637886 0 0 0.00282706266083767 0.999652858134691 0.998985842622235 0.999928405279598 21 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2508T>C rrl_n.2508T>C 2 non_coding_transcript_exon_variant 1476165 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2323 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1718 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2508T>G rrl_n.2508T>G 2 non_coding_transcript_exon_variant 1476165 NA 0 0 0 0 12 2049 15471 0 0 0.00179871197794837 0.999224956403797 0.99864654661041 0.999599461575238 0 0 0.264648469397051 NA NA NA 0 0 0.264648469397051 NA NA NA NA 1862 2386 False True 0 0 2.71972624224414 0 0 0.00179871197794837 0.999224956403797 0.99864654661041 0.999599461575238 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 11 1305 8631 0 0 0.00282273611850443 0.998727146493867 0.997723657451287 0.999364430275444 0 0 0.284914152918154 NA NA NA 0 0 0.284914152918154 NA NA NA NA 1293 1774 False True 0 1 1 0 0 0 0 0 0 2.63876604338672 0 0 0.00282273611850443 0.998727146493867 0.997723657451287 0.999364430275444 78 5) Not assoc w R New NotAwR yes 5 +Capreomycin rrl n.2509G>C rrl_n.2509G>C 2 non_coding_transcript_exon_variant 1476166 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2512A>G rrl_n.2512A>G 2 non_coding_transcript_exon_variant 1476169 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.251C>G rrl_n.251C>G 2 non_coding_transcript_exon_variant 1473908 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2524A>C rrl_n.2524A>C 2 non_coding_transcript_exon_variant 1476181 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2240 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1645 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2529T>C rrl_n.2529T>C 2 non_coding_transcript_exon_variant 1476186 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2537A>G rrl_n.2537A>G 2 non_coding_transcript_exon_variant 1476194 NA 0 0 0 0 10 2049 15473 0 0 0.00179871197794837 0.999354130336498 0.998812544515655 0.999690238326549 0 0 0.30849710781876 NA NA NA 0 0 0.30849710781876 NA NA NA NA 1682 2386 False True 0 0 3.37173073063401 0 0 0.00179871197794837 0.999354130336498 0.998812544515655 0.999690238326549 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 9 1305 8633 0 0 0.00282273611850443 0.998958574404073 0.998023974495813 0.999523686828456 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1120 1774 False True 1 1 1 0 0 0 0 0 0 3.35590194387839 0 0 0.00282273611850443 0.998958574404073 0.998023974495813 0.999523686828456 45 5) Not assoc w R New NotAwR yes 5 +Capreomycin rrl n.2538C>A rrl_n.2538C>A 2 non_coding_transcript_exon_variant 1476195 NA 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1926 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1351 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2539C>A rrl_n.2539C>A 2 non_coding_transcript_exon_variant 1476196 NA 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1683 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1121 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2543A>T rrl_n.2543A>T 2 non_coding_transcript_exon_variant 1476200 NA 0 0 0 0 9 2049 15474 0 0 0.00179871197794837 0.999418717302848 0.998896832459985 0.999734167184357 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1684 2386 False True 0 0 3.82923083971975 0 0 0.00179871197794837 0.999418717302848 0.998896832459985 0.999734167184357 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 8 1305 8634 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1122 1774 False True 1 1 1 0 0 0 0 0 0 3.88085962593317 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 37 5) Not assoc w R New NotAwR yes 5 +Capreomycin rrl n.2544C>T rrl_n.2544C>T 2 non_coding_transcript_exon_variant 1476201 NA 0 0 0 0 8 2049 15475 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1700 2386 False True 0 0 4.42794679154129 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 7 1305 8635 0 0 0.00282273611850443 0.999190002314279 0.998331811834773 0.999674278877205 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1136 1774 False True 1 1 1 0 0 0 0 0 0 4.59639609856608 0 0 0.00282273611850443 0.999190002314279 0.998331811834773 0.999674278877205 35 5) Not assoc w R New NotAwR yes 5 +Capreomycin rrl n.2547C>A rrl_n.2547C>A 2 non_coding_transcript_exon_variant 1476204 NA 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1829 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1261 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2553G>T rrl_n.2553G>T 2 non_coding_transcript_exon_variant 1476210 NA 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 2073 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1490 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2554G>T rrl_n.2554G>T 2 non_coding_transcript_exon_variant 1476211 NA 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 2168 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1577 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2555T>C rrl_n.2555T>C 2 non_coding_transcript_exon_variant 1476212 NA 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1685 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1123 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2557G>C rrl_n.2557G>C 2 non_coding_transcript_exon_variant 1476214 NA 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1948 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1372 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2557G>T rrl_n.2557G>T 2 non_coding_transcript_exon_variant 1476214 NA 0 0 0 0 7 2049 15476 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1830 2386 False False 0 0 5.24430081649792 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 7 1305 8635 0 0 0.00282273611850443 0.999190002314279 0.998331811834773 0.999674278877205 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1262 1774 False False 0 0 0 0 0 0 0 0 0 4.59639609856608 0 0 0.00282273611850443 0.999190002314279 0.998331811834773 0.999674278877205 22 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2558C>A rrl_n.2558C>A 2 non_coding_transcript_exon_variant 1476215 NA 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 2052 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1471 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2558C>T rrl_n.2558C>T 2 non_coding_transcript_exon_variant 1476215 NA 0 0 0 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1720 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 5 1305 8637 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1154 1774 False False 0 0 0 0 0 0 0 0 0 7.23014561016525 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 21 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2564T>C rrl_n.2564T>C 2 non_coding_transcript_exon_variant 1476221 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1787 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1220 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 5 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2565A>C rrl_n.2565A>C 2 non_coding_transcript_exon_variant 1476222 1 1 0 1 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 293.314465539138 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 257.173353425001 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2567A>G rrl_n.2567A>G 2 non_coding_transcript_exon_variant 1476224 NA 0 0 0 0 7 2049 15476 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1788 2386 False False 0 0 5.24430081649792 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 7 1305 8635 0 0 0.00282273611850443 0.999190002314279 0.998331811834773 0.999674278877205 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1221 1774 False False 0 0 0 0 0 0 0 0 0 4.59639609856608 0 0 0.00282273611850443 0.999190002314279 0.998331811834773 0.999674278877205 39 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2568T>G rrl_n.2568T>G 2 non_coding_transcript_exon_variant 1476225 NA 0 0 0 2 15 2047 15468 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.999031195504747 0.998402606935329 0.999457669301639 0.117647058823529 0.0145793168403025 0.36440916210125 NA NA NA 0 0 0.218019360910534 NA NA NA NA 1831 2386 False False 1.00752320468979 0.111713648797946 4.33756144038052 0 0 0.00180046780769359 0.999031195504747 0.998402606935329 0.999457669301639 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 14 1304 8628 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.998380004628558 0.99728341538717 0.999114059339894 0.0666666666666666 0.0016864302413527 0.319484566578303 NA NA NA 0 0 0.231635761650116 NA NA NA NA 1263 1774 False False 0 0 0 0 0 0 0 0.472611744084136 0.0111719189472547 3.11125356291235 0 0 0.00282489773306727 0.998380004628558 0.99728341538717 0.999114059339894 50 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2572C>G rrl_n.2572C>G 2 non_coding_transcript_exon_variant 1476229 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2360 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1754 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 13 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2572C>T rrl_n.2572C>T 2 non_coding_transcript_exon_variant 1476229 NA 0 0 0 0 6 2049 15477 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1810 2386 False False 0 0 6.41986758323506 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 6 1305 8636 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1243 1774 False False 0 0 0 0 0 0 0 0 0 5.62683462374212 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 34 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2588C>T rrl_n.2588C>T 2 non_coding_transcript_exon_variant 1476245 NA 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 2284 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1684 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 29 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2591G>A rrl_n.2591G>A 2 non_coding_transcript_exon_variant 1476248 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2593C>G rrl_n.2593C>G 2 non_coding_transcript_exon_variant 1476250 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2123 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1536 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 62 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2594T>A rrl_n.2594T>A 2 non_coding_transcript_exon_variant 1476251 NA 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2361 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1755 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 8 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2594T>C rrl_n.2594T>C 2 non_coding_transcript_exon_variant 1476251 NA 0 0 0 3 24 2046 15459 0.00146412884333821 0.000302040401839334 0.00427278776332334 0.998449912807595 0.997694465417801 0.999006585264568 0.111111111111111 0.0235274543808539 0.291586924273551 NA NA NA 0 0 0.142473597722525 NA NA NA NA 2324 2386 False False 0.944464809384164 0.181885646406014 3.11411286862499 0 0 0.00180134700867096 0.998449912807595 0.997694465417801 0.999006585264568 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 22 1303 8620 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.997454292987734 0.996148291078399 0.99840395257875 0.0833333333333333 0.0102563412812501 0.269972801557603 NA NA NA 0 0 0.154372512815574 NA NA NA NA 1719 1774 False False 0 0 0 0 0 0 0 0.601409335100816 0.0684769098444326 2.45137898894346 0 0 0.00282706266083767 0.997454292987734 0.996148291078399 0.99840395257875 103 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2594T>G rrl_n.2594T>G 2 non_coding_transcript_exon_variant 1476251 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2325 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1720 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 5 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2595T>A rrl_n.2595T>A 2 non_coding_transcript_exon_variant 1476252 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1965 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1387 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2595T>G rrl_n.2595T>G 2 non_coding_transcript_exon_variant 1476252 NA 0 0 0 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 2191 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 5 1305 8637 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1599 1774 False False 0 0 0 0 0 0 0 0 0 7.23014561016525 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 28 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2598A>G rrl_n.2598A>G 2 non_coding_transcript_exon_variant 1476255 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2192 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1600 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2599A>G rrl_n.2599A>G 2 non_coding_transcript_exon_variant 1476256 NA 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1721 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1155 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 17 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2599A>T rrl_n.2599A>T 2 non_coding_transcript_exon_variant 1476256 NA 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1966 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1388 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 7 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.259C>A rrl_n.259C>A 2 non_coding_transcript_exon_variant 1473916 NA 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1811 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1244 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 7 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.-25C>T rrl_n.-25C>T 2 upstream_gene_variant 1473633 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2600G>C rrl_n.2600G>C 2 non_coding_transcript_exon_variant 1476257 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2241 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1646 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 87 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2602C>G rrl_n.2602C>G 2 non_coding_transcript_exon_variant 1476259 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1722 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1156 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2603A>G rrl_n.2603A>G 2 non_coding_transcript_exon_variant 1476260 NA 0 0 0 3 35 2046 15448 0.00146412884333821 0.000302040401839334 0.00427278776332334 0.997739456177743 0.996857519632686 0.998424958795015 0.0789473684210526 0.0165864758645295 0.213773291180618 NA NA NA 0 0 0.100032435572105 NA NA NA NA 2341 2386 False True 0.647172182656053 0.127234161115166 2.05585538380989 0 0 0.00180134700867096 0.997739456177743 0.996857519632686 0.998424958795015 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 2 33 1303 8609 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.996181439481601 0.994641463239562 0.997370064788675 0.0571428571428571 0.00699676362830951 0.191571406345239 NA NA NA 0 0 0.105762810074579 NA NA NA NA 1735 1774 False True 0 1 1 0 0 0 0 0.4004279169283 0.0465053930968759 1.56902176927866 0 0 0.00282706266083767 0.996181439481601 0.994641463239562 0.997370064788675 176 5) Not assoc w R New NotAwR yes 5 +Capreomycin rrl n.2607A>T rrl_n.2607A>T 2 non_coding_transcript_exon_variant 1476264 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2611A>T rrl_n.2611A>T 2 non_coding_transcript_exon_variant 1476268 NA 0 0 0 0 6 2049 15477 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 2285 2386 False False 0 0 6.41986758323506 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 6 1305 8636 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1685 1774 False False 0 0 0 0 0 0 0 0 0 5.62683462374212 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 27 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2618T>A rrl_n.2618T>A 2 non_coding_transcript_exon_variant 1476275 NA 0 0 0 0 6 2049 15477 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 2008 2386 False False 0 0 6.41986758323506 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 6 1305 8636 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1426 1774 False False 0 0 0 0 0 0 0 0 0 5.62683462374212 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 26 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2622G>A rrl_n.2622G>A 2 non_coding_transcript_exon_variant 1476279 NA 0 0 0 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1832 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 5 1305 8637 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1264 1774 False False 0 0 0 0 0 0 0 0 0 7.23014561016525 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 27 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2623A>C rrl_n.2623A>C 2 non_coding_transcript_exon_variant 1476280 NA 0 0 0 2 26 2047 15457 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.998320738874895 0.997540454635474 0.998902766748277 0.0714285714285714 0.00877049670352713 0.23503477317459 NA NA NA 0 0 0.132274604497754 NA NA NA NA 1789 2386 False False 0.580850024425989 0.0667642803336721 2.3229912930724 0 0 0.00180046780769359 0.998320738874895 0.997540454635474 0.998902766748277 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 24 1304 8618 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.997222865077528 0.995870643521197 0.998219851703105 0.04 0.00101219969931084 0.203516913922414 NA NA NA 0 0 0.142473597722525 NA NA NA NA 1222 1774 False False 0 0 0 0 0 0 0 0.275370654396728 0.00669455930091021 1.69186362602383 0 0 0.00282489773306727 0.997222865077528 0.995870643521197 0.998219851703105 135 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2624T>C rrl_n.2624T>C 2 non_coding_transcript_exon_variant 1476281 NA 0 0 0 0 6 2049 15477 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1896 2386 False False 0 0 6.41986758323506 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 6 1305 8636 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1322 1774 False False 0 0 0 0 0 0 0 0 0 5.62683462374212 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 25 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2633C>A rrl_n.2633C>A 2 non_coding_transcript_exon_variant 1476290 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1701 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2636C>T rrl_n.2636C>T 2 non_coding_transcript_exon_variant 1476293 NA 0 0 0 0 14 2049 15469 0 0 0.00179871197794837 0.999095782471097 0.998483341560662 0.999505570487652 0 0 0.231635761650116 NA NA NA 0 0 0.231635761650116 NA NA NA NA 2326 2386 False False 0 0 2.27797115095248 0 0 0.00179871197794837 0.999095782471097 0.998483341560662 0.999505570487652 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 13 1305 8629 0 0 0.00282273611850443 0.998495718583661 0.997429006709305 0.999198798037271 0 0 0.24705263800047 NA NA NA 0 0 0.24705263800047 NA NA NA NA 1721 1774 False False 0 0 0 0 0 0 0 0 0 2.17279669430301 0 0 0.00282273611850443 0.998495718583661 0.997429006709305 0.999198798037271 29 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2637A>G rrl_n.2637A>G 2 non_coding_transcript_exon_variant 1476294 NA 0 0 0 0 14 2049 15469 0 0 0.00179871197794837 0.999095782471097 0.998483341560662 0.999505570487652 0 0 0.231635761650116 NA NA NA 0 0 0.231635761650116 NA NA NA NA 2193 2386 False False 0 0 2.27797115095248 0 0 0.00179871197794837 0.999095782471097 0.998483341560662 0.999505570487652 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 13 1305 8629 0 0 0.00282273611850443 0.998495718583661 0.997429006709305 0.999198798037271 0 0 0.24705263800047 NA NA NA 0 0 0.24705263800047 NA NA NA NA 1601 1774 False False 0 0 0 0 0 0 0 0 0 2.17279669430301 0 0 0.00282273611850443 0.998495718583661 0.997429006709305 0.999198798037271 30 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2638C>G rrl_n.2638C>G 2 non_coding_transcript_exon_variant 1476295 NA 0 0 0 0 14 2049 15469 0 0 0.00179871197794837 0.999095782471097 0.998483341560662 0.999505570487652 0 0 0.231635761650116 NA NA NA 0 0 0.231635761650116 NA NA NA NA 2194 2386 False False 0 0 2.27797115095248 0 0 0.00179871197794837 0.999095782471097 0.998483341560662 0.999505570487652 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 13 1305 8629 0 0 0.00282273611850443 0.998495718583661 0.997429006709305 0.999198798037271 0 0 0.24705263800047 NA NA NA 0 0 0.24705263800047 NA NA NA NA 1602 1774 False False 0 0 0 0 0 0 0 0 0 2.17279669430301 0 0 0.00282273611850443 0.998495718583661 0.997429006709305 0.999198798037271 31 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2639C>T rrl_n.2639C>T 2 non_coding_transcript_exon_variant 1476296 NA 0 0 0 0 14 2049 15469 0 0 0.00179871197794837 0.999095782471097 0.998483341560662 0.999505570487652 0 0 0.231635761650116 NA NA NA 0 0 0.231635761650116 NA NA NA NA 1833 2386 False False 0 0 2.27797115095248 0 0 0.00179871197794837 0.999095782471097 0.998483341560662 0.999505570487652 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 13 1305 8629 0 0 0.00282273611850443 0.998495718583661 0.997429006709305 0.999198798037271 0 0 0.24705263800047 NA NA NA 0 0 0.24705263800047 NA NA NA NA 1265 1774 False False 0 0 0 0 0 0 0 0 0 2.17279669430301 0 0 0.00282273611850443 0.998495718583661 0.997429006709305 0.999198798037271 31 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2640C>A rrl_n.2640C>A 2 non_coding_transcript_exon_variant 1476297 NA 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2342 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1736 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2640C>G rrl_n.2640C>G 2 non_coding_transcript_exon_variant 1476297 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1878 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1308 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2640C>T rrl_n.2640C>T 2 non_coding_transcript_exon_variant 1476297 1 1 0 1 0 14 2049 15469 0 0 0.00179871197794837 0.999095782471097 0.998483341560662 0.999505570487652 0 0 0.231635761650116 0 0 0.975 0 0 0.231635761650116 0 0 293.107005905184 1 194.5 2386 False False 0 0 2.27797115095248 0 0 0.00179871197794837 0.999095782471097 0.998483341560662 0.999505570487652 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 13 1305 8629 0 0 0.00282273611850443 0.998495718583661 0.997429006709305 0.999198798037271 0 0 0.24705263800047 0 0 0.975 0 0 0.24705263800047 0 0 256.876893776437 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 2.17279669430301 0 0 0.00282273611850443 0.998495718583661 0.997429006709305 0.999198798037271 31 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2641C>G rrl_n.2641C>G 2 non_coding_transcript_exon_variant 1476298 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2303 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1702 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2642C>T rrl_n.2642C>T 2 non_coding_transcript_exon_variant 1476299 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1897 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1323 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2643G>A rrl_n.2643G>A 2 non_coding_transcript_exon_variant 1476300 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2362 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1756 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2644A>C rrl_n.2644A>C 2 non_coding_transcript_exon_variant 1476301 NA 0 0 0 0 12 2049 15471 0 0 0.00179871197794837 0.999224956403797 0.99864654661041 0.999599461575238 0 0 0.264648469397051 NA NA NA 0 0 0.264648469397051 NA NA NA NA 2169 2386 False False 0 0 2.71972624224414 0 0 0.00179871197794837 0.999224956403797 0.99864654661041 0.999599461575238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 11 1305 8631 0 0 0.00282273611850443 0.998727146493867 0.997723657451287 0.999364430275444 0 0 0.284914152918154 NA NA NA 0 0 0.284914152918154 NA NA NA NA 1578 1774 False False 0 0 0 0 0 0 0 0 0 2.63876604338672 0 0 0.00282273611850443 0.998727146493867 0.997723657451287 0.999364430275444 19 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2644A>T rrl_n.2644A>T 2 non_coding_transcript_exon_variant 1476301 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2009 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1427 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 11 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2645G>A rrl_n.2645G>A 2 non_coding_transcript_exon_variant 1476302 NA 0 0 0 0 14 2049 15469 0 0 0.00179871197794837 0.999095782471097 0.998483341560662 0.999505570487652 0 0 0.231635761650116 NA NA NA 0 0 0.231635761650116 NA NA NA NA 2242 2386 False False 0 0 2.27797115095248 0 0 0.00179871197794837 0.999095782471097 0.998483341560662 0.999505570487652 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 13 1305 8629 0 0 0.00282273611850443 0.998495718583661 0.997429006709305 0.999198798037271 0 0 0.24705263800047 NA NA NA 0 0 0.24705263800047 NA NA NA NA 1647 1774 False False 0 0 0 0 0 0 0 0 0 2.17279669430301 0 0 0.00282273611850443 0.998495718583661 0.997429006709305 0.999198798037271 25 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2652G>C rrl_n.2652G>C 2 non_coding_transcript_exon_variant 1476309 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2304 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1703 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2654G>C rrl_n.2654G>C 2 non_coding_transcript_exon_variant 1476311 NA 0 0 0 0 21 2049 15462 0 0 0.00179871197794837 0.998643673706646 0.997927454478736 0.999160222740807 0 0 0.161097615219079 NA NA NA 0 0 0.161097615219079 NA NA NA NA 1834 2386 False False 0 0 1.45049914622996 0 0 0.00179871197794837 0.998643673706646 0.997927454478736 0.999160222740807 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 20 1305 8622 0 0 0.00282273611850443 0.99768572089794 0.996428035548426 0.998585822914007 0 0 0.168433470983085 NA NA NA 0 0 0.168433470983085 NA NA NA NA 1266 1774 False False 0 0 0 0 0 0 0 0 0 1.34028139618707 0 0 0.00282273611850443 0.99768572089794 0.996428035548426 0.998585822914007 36 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2655T>C rrl_n.2655T>C 2 non_coding_transcript_exon_variant 1476312 NA 0 0 0 0 21 2049 15462 0 0 0.00179871197794837 0.998643673706646 0.997927454478736 0.999160222740807 0 0 0.161097615219079 NA NA NA 0 0 0.161097615219079 NA NA NA NA 1812 2386 False False 0 0 1.45049914622996 0 0 0.00179871197794837 0.998643673706646 0.997927454478736 0.999160222740807 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 20 1305 8622 0 0 0.00282273611850443 0.99768572089794 0.996428035548426 0.998585822914007 0 0 0.168433470983085 NA NA NA 0 0 0.168433470983085 NA NA NA NA 1245 1774 False False 0 0 0 0 0 0 0 0 0 1.34028139618707 0 0 0.00282273611850443 0.99768572089794 0.996428035548426 0.998585822914007 37 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2656G>A rrl_n.2656G>A 2 non_coding_transcript_exon_variant 1476313 NA 0 0 0 0 21 2049 15462 0 0 0.00179871197794837 0.998643673706646 0.997927454478736 0.999160222740807 0 0 0.161097615219079 NA NA NA 0 0 0.161097615219079 NA NA NA NA 2305 2386 False False 0 0 1.45049914622996 0 0 0.00179871197794837 0.998643673706646 0.997927454478736 0.999160222740807 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 20 1305 8622 0 0 0.00282273611850443 0.99768572089794 0.996428035548426 0.998585822914007 0 0 0.168433470983085 NA NA NA 0 0 0.168433470983085 NA NA NA NA 1704 1774 False False 0 0 0 0 0 0 0 0 0 1.34028139618707 0 0 0.00282273611850443 0.99768572089794 0.996428035548426 0.998585822914007 31 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.266_267delCAinsGAT rrl_n.266_267delCAinsGAT 2 non_coding_transcript_exon_variant 1473923 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2343 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1737 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.266C>G rrl_n.266C>G 2 non_coding_transcript_exon_variant 1473923 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1898 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1324 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 26 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.266C>T rrl_n.266C>T 2 non_coding_transcript_exon_variant 1473923 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2671_2672insT rrl_n.2671_2672insT 2 non_coding_transcript_exon_variant 1476328 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2675G>C rrl_n.2675G>C 2 non_coding_transcript_exon_variant 1476332 NA 0 0 0 2 28 2047 15455 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.998191564942194 0.997387360340353 0.998797982072775 0.0666666666666666 0.00817813446065631 0.220735401522961 NA NA NA 0 0 0.123436118500263 NA NA NA NA 1723 2386 False False 0.539290948426268 0.0622150847338832 2.14138622480865 0 0 0.00180046780769359 0.998191564942194 0.997387360340353 0.998797982072775 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 26 1304 8616 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.996991437167322 0.995594844195753 0.998033794414764 0.037037037037037 0.000937257091944708 0.189705617413044 NA NA NA 0 0 0.132274604497754 NA NA NA NA 1157 1774 False False 0 0 0 0 0 0 0 0.254129306276545 0.00619727995019974 1.54982610714653 0 0 0.00282489773306727 0.996991437167322 0.995594844195753 0.998033794414764 99 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2680C>T rrl_n.2680C>T 2 non_coding_transcript_exon_variant 1476337 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2344 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1738 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 6 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2681C>T rrl_n.2681C>T 2 non_coding_transcript_exon_variant 1476338 NA 0 0 0 1 9 2048 15474 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999418717302848 0.998896832459985 0.999734167184357 0.1 0.00252857854446178 0.445016117028195 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1748 2386 False False 0.839518229166666 0.0191442481599193 6.06407759157277 0 0 0.00179958946453767 0.999418717302848 0.998896832459985 0.999734167184357 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 8 1304 8634 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999074288359176 0.998176798225858 0.999600261389848 0.111111111111111 0.00280913674659921 0.482496514917337 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1183 1774 False False 0 0 0 0 0 0 0 0.827645705521472 0.0186379987589414 6.18187193560828 0 0 0.00282489773306727 0.999074288359176 0.998176798225858 0.999600261389848 73 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2691A>T rrl_n.2691A>T 2 non_coding_transcript_exon_variant 1476348 1 0 0 0 2 2 2047 15481 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.999870826067299 0.999533458063883 0.999984356054634 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1899 2386 False False 7.56277479237909 0.547801158574908 104.389914324374 0 0 0.00180046780769359 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 2 1303 8640 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.999768572089794 0.999164255486522 0.999971971777513 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1325 1774 False False 0 0 0 0 0 0 0 6.63085188027628 0.480082065417988 91.6551467569938 0 0 0.00282706266083767 0.999768572089794 0.999164255486522 0.999971971777513 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2696G>T rrl_n.2696G>T 2 non_coding_transcript_exon_variant 1476353 NA 0 0 0 2 30 2047 15453 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.998062391009494 0.99723508866369 0.998692333308913 0.0625 0.00766073634645639 0.208069429895007 NA NA NA 0 0 0.115703308222027 NA NA NA NA 2029 2386 False False 0.503273082559843 0.0582413977858185 1.98592876745223 0 0 0.00180046780769359 0.998062391009494 0.99723508866369 0.998692333308913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 28 1304 8614 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.996760009257116 0.995320690097596 0.997846002850141 0.0344827586206896 0.000872646883579922 0.177644295488722 NA NA NA 0 0 0.123436118500263 NA NA NA NA 1447 1774 False False 0 0 0 0 0 0 0 0.235922436459246 0.00576862487092938 1.42966193709609 0 0 0.00282489773306727 0.996760009257116 0.995320690097596 0.997846002850141 102 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.269G>C rrl_n.269G>C 2 non_coding_transcript_exon_variant 1473926 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1900 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1326 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 24 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.26G>A rrl_n.26G>A 2 non_coding_transcript_exon_variant 1473683 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.-26G>A rrl_n.-26G>A 2 upstream_gene_variant 1473632 1 1 0 1 0 9 2049 15474 0 0 0.00179871197794837 0.999418717302848 0.998896832459985 0.999734167184357 0 0 0.336267116879942 0 0 0.975 0 0 0.336267116879942 0 0 293.2013059063 1 619.5 2386 False False 0 0 3.82923083971975 0 0 0.00179871197794837 0.999418717302848 0.998896832459985 0.999734167184357 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 8 1305 8634 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1107 1774 False False 0 0 0 0 0 0 0 0 0 3.88085962593317 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2701T>C rrl_n.2701T>C 2 non_coding_transcript_exon_variant 1476358 NA 0 0 0 2 33 2047 15450 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.997868630110443 0.997008054406869 0.998532422825367 0.0571428571428571 0.00699676362830951 0.191571406345239 NA NA NA 0 0 0.105762810074579 NA NA NA NA 2345 2386 False False 0.457432162366212 0.0531477889507742 1.79079705707136 0 0 0.00180046780769359 0.997868630110443 0.997008054406869 0.998532422825367 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 31 1304 8611 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.996412867391807 0.99491218317048 0.997561455575301 0.03125 0.000790868597952557 0.162170994181511 NA NA NA 0 0 0.11218874692237 NA NA NA NA 1739 1774 False False 0 0 0 0 0 0 0 0.213017019592321 0.00522615386258043 1.2806051162804 0 0 0.00282489773306727 0.996412867391807 0.99491218317048 0.997561455575301 121 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2702C>G rrl_n.2702C>G 2 non_coding_transcript_exon_variant 1476359 NA 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 2217 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1623 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 82 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2711T>C rrl_n.2711T>C 2 non_coding_transcript_exon_variant 1476368 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1863 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1294 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 10 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2712C>T rrl_n.2712C>T 2 non_coding_transcript_exon_variant 1476369 NA 0 0 0 0 8 2049 15475 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 2260 2386 False False 0 0 4.42794679154129 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 8 1305 8634 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1663 1774 False False 0 0 0 0 0 0 0 0 0 3.88085962593317 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 101 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2715T>C rrl_n.2715T>C 2 non_coding_transcript_exon_variant 1476372 NA 0 0 0 2 31 2047 15452 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.997997804043144 0.997159236175471 0.998639212087747 0.0606060606060606 0.0074258377422598 0.202264312526355 NA NA NA 0 0 0.11218874692237 NA NA NA NA 1901 2386 False False 0.487006949587909 0.05643865475883 1.91642211687002 0 0 0.00180046780769359 0.997997804043144 0.997159236175471 0.998639212087747 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 29 1304 8613 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.996644295302013 0.995184176294224 0.997751515158685 0.0333333333333333 0.000843570926630479 0.172169455633412 NA NA NA 0 0 0.119444869069502 NA NA NA NA 1327 1774 False False 0 0 0 0 0 0 0 0.227760736196319 0.00557574043458002 1.37629320071018 0 0 0.00282489773306727 0.996644295302013 0.995184176294224 0.997751515158685 104 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2724G>C rrl_n.2724G>C 2 non_coding_transcript_exon_variant 1476381 NA 0 0 0 0 6 2049 15477 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 2218 2386 False False 0 0 6.41986758323506 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 6 1305 8636 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1624 1774 False False 0 0 0 0 0 0 0 0 0 5.62683462374212 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 115 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2725A>G rrl_n.2725A>G 2 non_coding_transcript_exon_variant 1476382 NA 0 0 0 2 28 2047 15455 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.998191564942194 0.997387360340353 0.998797982072775 0.0666666666666666 0.00817813446065631 0.220735401522961 NA NA NA 0 0 0.123436118500263 NA NA NA NA 1835 2386 False False 0.539290948426268 0.0622150847338832 2.14138622480865 0 0 0.00180046780769359 0.998191564942194 0.997387360340353 0.998797982072775 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 26 1304 8616 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.996991437167322 0.995594844195753 0.998033794414764 0.037037037037037 0.000937257091944708 0.189705617413044 NA NA NA 0 0 0.132274604497754 NA NA NA NA 1267 1774 False False 0 0 0 0 0 0 0 0.254129306276545 0.00619727995019974 1.54982610714653 0 0 0.00282489773306727 0.996991437167322 0.995594844195753 0.998033794414764 119 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2726T>A rrl_n.2726T>A 2 non_coding_transcript_exon_variant 1476383 NA 0 0 0 2 28 2047 15455 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.998191564942194 0.997387360340353 0.998797982072775 0.0666666666666666 0.00817813446065631 0.220735401522961 NA NA NA 0 0 0.123436118500263 NA NA NA NA 2153 2386 False False 0.539290948426268 0.0622150847338832 2.14138622480865 0 0 0.00180046780769359 0.998191564942194 0.997387360340353 0.998797982072775 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 26 1304 8616 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.996991437167322 0.995594844195753 0.998033794414764 0.037037037037037 0.000937257091944708 0.189705617413044 NA NA NA 0 0 0.132274604497754 NA NA NA NA 1563 1774 False False 0 0 0 0 0 0 0 0.254129306276545 0.00619727995019974 1.54982610714653 0 0 0.00282489773306727 0.996991437167322 0.995594844195753 0.998033794414764 112 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2738T>A rrl_n.2738T>A 2 non_coding_transcript_exon_variant 1476395 NA 0 0 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1927 2386 False False Inf 0.193753017505121 Inf 0 0 0.00179958946453767 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1352 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0 0 0.00282489773306727 1 0.999573236258028 1 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2751G>A rrl_n.2751G>A 2 non_coding_transcript_exon_variant 1476408 NA 0 0 0 2 29 2047 15454 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.998126977975844 0.997311126912655 0.998745260027249 0.064516129032258 0.0079109834618547 0.214216157163402 NA NA NA 0 0 0.119444869069502 NA NA NA NA 1864 2386 False False 0.520661017805703 0.0601628313584226 2.06078737638921 0 0 0.00180046780769359 0.998126977975844 0.997311126912655 0.998745260027249 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 27 1304 8615 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.996875723212219 0.995457572720973 0.997940103183564 0.0357142857142857 0.000903798755658059 0.183477597544623 NA NA NA 0 0 0.127702867615432 NA NA NA NA 1295 1774 False False 0 0 0 0 0 0 0 0.24468870711202 0.00597529390524684 1.48731156798156 0 0 0.00282489773306727 0.996875723212219 0.995457572720973 0.997940103183564 82 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2755C>T rrl_n.2755C>T 2 non_coding_transcript_exon_variant 1476412 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.275C>T rrl_n.275C>T 2 non_coding_transcript_exon_variant 1473932 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2760T>C rrl_n.2760T>C 2 non_coding_transcript_exon_variant 1476417 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 35.2688392655279 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 8 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2766T>C rrl_n.2766T>C 2 non_coding_transcript_exon_variant 1476423 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1702 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2768G>A rrl_n.2768G>A 2 non_coding_transcript_exon_variant 1476425 NA 0 0 0 0 6 2049 15477 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 2243 2386 False False 0 0 6.41986758323506 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 5 1305 8637 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1648 1774 False False 0 0 0 0 0 0 0 0 0 7.23014561016525 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 16 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2768G>T rrl_n.2768G>T 2 non_coding_transcript_exon_variant 1476425 NA 0 0 0 1 23 2048 15460 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.998514499773945 0.997771848972111 0.999058094518622 0.0416666666666666 0.00105435244546974 0.211201683456973 NA NA NA 0 0 0.148185128915224 NA NA NA NA 2074 2386 False False 0.32820991847826 0.00796688820438469 2.02338912264225 0 0 0.00179958946453767 0.998514499773945 0.997771848972111 0.999058094518622 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 22 1305 8620 0 0 0.00282273611850443 0.997454292987734 0.996148291078399 0.99840395257875 0 0 0.154372512815574 NA NA NA 0 0 0.154372512815574 NA NA NA NA 1491 1774 False False 0 0 0 0 0 0 0 0 0 1.20770470435535 0 0 0.00282273611850443 0.997454292987734 0.996148291078399 0.99840395257875 94 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.276C>T rrl_n.276C>T 2 non_coding_transcript_exon_variant 1473933 1 2 0 2 1 2 2048 15481 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999870826067299 0.999533458063883 0.999984356054634 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2563859690691 1 619.5 2386 False False 3.779541015625 0.0640320806562028 72.4657839845296 0 0 0.00179958946453767 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 1304 8641 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999884286044897 0.999355453609522 0.999997070380594 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 257.429115860043 1 503.5 1774 False False 0 0 0 0 0 0 0 6.62653374233128 0.0843535983905244 517.917818294861 0 0 0.00282489773306727 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2771C>T rrl_n.2771C>T 2 non_coding_transcript_exon_variant 1476428 NA 0 0 0 1 35 2048 15448 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.997739456177743 0.996857519632686 0.998424958795015 0.0277777777777777 0.00070302520590478 0.145289264746853 NA NA NA 0 0 0.100032435572105 NA NA NA NA 2195 2386 False True 0.215513392857142 0.00530748202398333 1.28373109594578 0 0 0.00179958946453767 0.997739456177743 0.996857519632686 0.998424958795015 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 33 1305 8609 0 0 0.00282273611850443 0.996181439481601 0.994641463239562 0.997370064788675 0 0 0.105762810074579 NA NA NA 0 0 0.105762810074579 NA NA NA NA 1603 1774 False True 0 1 1 0 0 0 0 0 0 0.781486730021381 0 0 0.00282273611850443 0.996181439481601 0.994641463239562 0.997370064788675 189 5) Not assoc w R New NotAwR yes 5 +Capreomycin rrl n.2772A>C rrl_n.2772A>C 2 non_coding_transcript_exon_variant 1476429 NA 0 0 0 1 27 2048 15456 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.998256151908544 0.997463799190087 0.998850488356206 0.0357142857142857 0.000903798755658059 0.183477597544623 NA NA NA 0 0 0.127702867615432 NA NA NA NA 2327 2386 False False 0.279513888888888 0.00682701185420005 1.69785809346147 0 0 0.00179958946453767 0.998256151908544 0.997463799190087 0.998850488356206 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 26 1305 8616 0 0 0.00282273611850443 0.996991437167322 0.995594844195753 0.998033794414764 0 0 0.132274604497754 NA NA NA 0 0 0.132274604497754 NA NA NA NA 1722 1774 False False 0 0 0 0 0 0 0 0 0 1.00803054121899 0 0 0.00282273611850443 0.996991437167322 0.995594844195753 0.998033794414764 140 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2772A>T rrl_n.2772A>T 2 non_coding_transcript_exon_variant 1476429 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2170 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1579 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 55 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2779A>G rrl_n.2779A>G 2 non_coding_transcript_exon_variant 1476436 1 6 0 6 0 8 2049 15475 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 0 0 0.369416647552819 0 0 0.4592581264399 0 0 0.369416647552819 0 0 6.41903799733435 1 619.5 2386 False False 0 0 4.42794679154129 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 35.2606789358977 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 10 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2781G>A rrl_n.2781G>A 2 non_coding_transcript_exon_variant 1476438 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1813 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.-27T>G rrl_n.-27T>G 2 upstream_gene_variant 1473631 NA 0 0 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2160 2386 False False Inf 0.193753017505121 Inf 0 0 0.00179958946453767 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2809C>T rrl_n.2809C>T 2 non_coding_transcript_exon_variant 1476466 NA 0 0 0 2 35 2047 15448 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.997739456177743 0.996857519632686 0.998424958795015 0.054054054054054 0.00661457041152882 0.181949118377749 NA NA NA 0 0 0.100032435572105 NA NA NA NA 1749 2386 False True 0.431237350826994 0.0502187406385665 1.68074569905692 0 0 0.00180046780769359 0.997739456177743 0.996857519632686 0.998424958795015 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 1 33 1304 8609 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.996181439481601 0.994641463239562 0.997370064788675 0.0294117647058823 0.00074436423469026 0.153267669560317 NA NA NA 0 0 0.105762810074579 NA NA NA NA 1184 1774 False True 0 1 1 0 0 0 0 0.200060420152444 0.0049177128337302 1.19731351839901 0 0 0.00282489773306727 0.996181439481601 0.994641463239562 0.997370064788675 143 5) Not assoc w R New NotAwR yes 5 +Capreomycin rrl n.280C>A rrl_n.280C>A 2 non_coding_transcript_exon_variant 1473937 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2154 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1564 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.280C>G rrl_n.280C>G 2 non_coding_transcript_exon_variant 1473937 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.280C>T rrl_n.280C>T 2 non_coding_transcript_exon_variant 1473937 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2155 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1565 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2810A>C rrl_n.2810A>C 2 non_coding_transcript_exon_variant 1476467 NA 0 0 0 3 0 2046 15483 0.00146412884333821 0.000302040401839334 0.00427278776332334 1 0.999761774846946 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1879 2386 False False Inf 3.12435736045911 Inf 0 0 0.00180134700867096 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 1302 8642 0.00229885057471264 0.000474329389656033 0.00670338609202181 1 0.999573236258028 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1309 1774 False False 0 0 0 0 0 0 0 Inf 2.73902522369248 Inf 0 0 0.00282923090943894 1 0.999573236258028 1 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2813C>T rrl_n.2813C>T 2 non_coding_transcript_exon_variant 1476470 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 17 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2814G>T rrl_n.2814G>T 2 non_coding_transcript_exon_variant 1476471 1 2 0 2 10 10 2039 15473 0.00488042947779404 0.0023427615854433 0.00895691175610291 0.999354130336498 0.998812544515655 0.999690238326549 0.5 0.271957849560791 0.728042150439208 0 0 0.841886116991581 0 0 0.30849710781876 0 0 40.4130223939283 1 619.5 2386 False False 7.58852378616969 2.8302891419468 20.332732098498 0 0 0.00180752554043533 0.999354130336498 0.998812544515655 0.999690238326549 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 5 1 1300 8641 0.00383141762452107 0.00124518543639507 0.00891842567874012 0.999884286044897 0.999355453609522 0.999997070380594 0.833333333333333 0.358765421002325 0.99578925548551 NA NA NA 0 0 0.975 NA NA NA NA 1373 1774 False False 0 0 0 0 0 0 0 33.2346153846153 3.71256023987202 1557.60398309729 0 0 0.00283357739974438 0.999884286044897 0.999355453609522 0.999997070380594 6 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2824T>C rrl_n.2824T>C 2 non_coding_transcript_exon_variant 1476481 NA 0 0 0 2 38 2047 15445 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.997545695278692 0.996632815663458 0.998262620434091 0.05 0.00611364659935083 0.169196863959417 NA NA NA 0 0 0.0925127614158782 NA NA NA NA 1902 2386 False True 0.397115162111433 0.0463829714638267 1.53862719044604 0 0 0.00180046780769359 0.997545695278692 0.996632815663458 0.998262620434091 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 1 36 1304 8606 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.995834297616292 0.994237531784846 0.997080738925974 0.027027027027027 0.000684031024694665 0.141603095611158 NA NA NA 0 0 0.0973937559144919 NA NA NA NA 1328 1774 False True 0 1 1 0 0 0 0 0.183324812542603 0.00451759799585633 1.09077058634549 0 0 0.00282489773306727 0.995834297616292 0.994237531784846 0.997080738925974 184 5) Not assoc w R New NotAwR yes 5 +Capreomycin rrl n.2849T>C rrl_n.2849T>C 2 non_coding_transcript_exon_variant 1476506 NA 0 0 0 2 40 2047 15443 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.997416521345992 0.99648367957731 0.998153703147083 0.0476190476190476 0.00581982483550999 0.161641959691653 NA NA NA 0 0 0.0880973028788023 NA NA NA NA 1724 2386 False True 0.377210552027357 0.0441347642571434 1.45653987189493 0 0 0.00180046780769359 0.997416521345992 0.99648367957731 0.998153703147083 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 1 38 1304 8604 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.995602869706086 0.993969541437374 0.996886506176495 0.0256410256410256 0.000648963895481945 0.134763921559497 NA NA NA 0 0 0.0925127614158782 NA NA NA NA 1158 1774 False True 0 1 1 0 0 0 0 0.173635776557959 0.00428506558568383 1.02968042342559 0 0 0.00282489773306727 0.995602869706086 0.993969541437374 0.996886506176495 169 5) Not assoc w R New NotAwR yes 5 +Capreomycin rrl n.284T>C rrl_n.284T>C 2 non_coding_transcript_exon_variant 1473941 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2855C>T rrl_n.2855C>T 2 non_coding_transcript_exon_variant 1476512 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1903 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1329 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2857C>T rrl_n.2857C>T 2 non_coding_transcript_exon_variant 1476514 NA 0 0 0 0 8 2049 15475 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1986 2386 False False 0 0 4.42794679154129 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 7 1305 8635 0 0 0.00282273611850443 0.999190002314279 0.998331811834773 0.999674278877205 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1407 1774 False False 0 0 0 0 0 0 0 0 0 4.59639609856608 0 0 0.00282273611850443 0.999190002314279 0.998331811834773 0.999674278877205 24 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2858C>T rrl_n.2858C>T 2 non_coding_transcript_exon_variant 1476515 NA 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2196 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1604 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 19 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.285G>C rrl_n.285G>C 2 non_coding_transcript_exon_variant 1473942 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2860C>T rrl_n.2860C>T 2 non_coding_transcript_exon_variant 1476517 NA 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1967 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1389 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 23 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2862C>G rrl_n.2862C>G 2 non_coding_transcript_exon_variant 1476519 NA 0 0 0 0 8 2049 15475 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1750 2386 False False 0 0 4.42794679154129 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 7 1305 8635 0 0 0.00282273611850443 0.999190002314279 0.998331811834773 0.999674278877205 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1185 1774 False False 0 0 0 0 0 0 0 0 0 4.59639609856608 0 0 0.00282273611850443 0.999190002314279 0.998331811834773 0.999674278877205 24 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2866T>C rrl_n.2866T>C 2 non_coding_transcript_exon_variant 1476523 NA 0 0 0 0 6 2049 15477 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 2053 2386 False False 0 0 6.41986758323506 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 5 1305 8637 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1472 1774 False False 0 0 0 0 0 0 0 0 0 7.23014561016525 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 5 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2867C>A rrl_n.2867C>A 2 non_coding_transcript_exon_variant 1476524 NA 0 0 0 0 12 2049 15471 0 0 0.00179871197794837 0.999224956403797 0.99864654661041 0.999599461575238 0 0 0.264648469397051 NA NA NA 0 0 0.264648469397051 NA NA NA NA 1751 2386 False False 0 0 2.71972624224414 0 0 0.00179871197794837 0.999224956403797 0.99864654661041 0.999599461575238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 11 1305 8631 0 0 0.00282273611850443 0.998727146493867 0.997723657451287 0.999364430275444 0 0 0.284914152918154 NA NA NA 0 0 0.284914152918154 NA NA NA NA 1186 1774 False False 0 0 0 0 0 0 0 0 0 2.63876604338672 0 0 0.00282273611850443 0.998727146493867 0.997723657451287 0.999364430275444 30 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2868A>G rrl_n.2868A>G 2 non_coding_transcript_exon_variant 1476525 NA 0 0 0 0 12 2049 15471 0 0 0.00179871197794837 0.999224956403797 0.99864654661041 0.999599461575238 0 0 0.264648469397051 NA NA NA 0 0 0.264648469397051 NA NA NA NA 1987 2386 False False 0 0 2.71972624224414 0 0 0.00179871197794837 0.999224956403797 0.99864654661041 0.999599461575238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 11 1305 8631 0 0 0.00282273611850443 0.998727146493867 0.997723657451287 0.999364430275444 0 0 0.284914152918154 NA NA NA 0 0 0.284914152918154 NA NA NA NA 1408 1774 False False 0 0 0 0 0 0 0 0 0 2.63876604338672 0 0 0.00282273611850443 0.998727146493867 0.997723657451287 0.999364430275444 34 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.286G>T rrl_n.286G>T 2 non_coding_transcript_exon_variant 1473943 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2219 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1625 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2871A>G rrl_n.2871A>G 2 non_coding_transcript_exon_variant 1476528 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1904 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1330 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2872A>G rrl_n.2872A>G 2 non_coding_transcript_exon_variant 1476529 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2030 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1448 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2872A>T rrl_n.2872A>T 2 non_coding_transcript_exon_variant 1476529 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1790 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1223 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2873C>T rrl_n.2873C>T 2 non_coding_transcript_exon_variant 1476530 NA 0 0 0 0 9 2049 15474 0 0 0.00179871197794837 0.999418717302848 0.998896832459985 0.999734167184357 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1703 2386 False False 0 0 3.82923083971975 0 0 0.00179871197794837 0.999418717302848 0.998896832459985 0.999734167184357 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 8 1305 8634 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1137 1774 False False 0 0 0 0 0 0 0 0 0 3.88085962593317 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 25 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2879G>A rrl_n.2879G>A 2 non_coding_transcript_exon_variant 1476536 NA 0 0 0 0 11 2049 15472 0 0 0.00179871197794837 0.999289543370148 0.998729153244051 0.999645290955256 0 0 0.284914152918154 NA NA NA 0 0 0.284914152918154 NA NA NA NA 2306 2386 False False 0 0 3.01101772028239 0 0 0.00179871197794837 0.999289543370148 0.998729153244051 0.999645290955256 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 10 1305 8632 0 0 0.00282273611850443 0.99884286044897 0.997873012135272 0.999444971558315 0 0 0.30849710781876 NA NA NA 0 0 0.30849710781876 NA NA NA NA 1705 1774 False False 0 0 0 0 0 0 0 0 0 2.9548002607889 0 0 0.00282273611850443 0.99884286044897 0.997873012135272 0.999444971558315 33 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.287G>C rrl_n.287G>C 2 non_coding_transcript_exon_variant 1473944 1 2 0 2 1 2 2048 15481 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999870826067299 0.999533458063883 0.999984356054634 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2563859690691 1 619.5 2386 False False 3.779541015625 0.0640320806562028 72.4657839845296 0 0 0.00179958946453767 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 1304 8640 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999768572089794 0.999164255486522 0.999971971777513 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 35.2958866065447 1 503.5 1774 False False 0 0 0 0 0 0 0 3.31288343558282 0.056110603773561 63.7302235362974 0 0 0.00282489773306727 0.999768572089794 0.999164255486522 0.999971971777513 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2880A>G rrl_n.2880A>G 2 non_coding_transcript_exon_variant 1476537 NA 0 0 0 0 9 2049 15474 0 0 0.00179871197794837 0.999418717302848 0.998896832459985 0.999734167184357 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 2328 2386 False False 0 0 3.82923083971975 0 0 0.00179871197794837 0.999418717302848 0.998896832459985 0.999734167184357 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 8 1305 8634 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1723 1774 False False 0 0 0 0 0 0 0 0 0 3.88085962593317 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 21 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2881A>G rrl_n.2881A>G 2 non_coding_transcript_exon_variant 1476538 NA 0 0 0 0 11 2049 15472 0 0 0.00179871197794837 0.999289543370148 0.998729153244051 0.999645290955256 0 0 0.284914152918154 NA NA NA 0 0 0.284914152918154 NA NA NA NA 1949 2386 False False 0 0 3.01101772028239 0 0 0.00179871197794837 0.999289543370148 0.998729153244051 0.999645290955256 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 10 1305 8632 0 0 0.00282273611850443 0.99884286044897 0.997873012135272 0.999444971558315 0 0 0.30849710781876 NA NA NA 0 0 0.30849710781876 NA NA NA NA 1374 1774 False False 0 0 0 0 0 0 0 0 0 2.9548002607889 0 0 0.00282273611850443 0.99884286044897 0.997873012135272 0.999444971558315 25 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2882A>G rrl_n.2882A>G 2 non_coding_transcript_exon_variant 1476539 1 1 0 1 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 293.314465539138 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1566 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 12 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2883C>G rrl_n.2883C>G 2 non_coding_transcript_exon_variant 1476540 NA 0 0 0 0 11 2049 15472 0 0 0.00179871197794837 0.999289543370148 0.998729153244051 0.999645290955256 0 0 0.284914152918154 NA NA NA 0 0 0.284914152918154 NA NA NA NA 2099 2386 False False 0 0 3.01101772028239 0 0 0.00179871197794837 0.999289543370148 0.998729153244051 0.999645290955256 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 10 1305 8632 0 0 0.00282273611850443 0.99884286044897 0.997873012135272 0.999444971558315 0 0 0.30849710781876 NA NA NA 0 0 0.30849710781876 NA NA NA NA 1514 1774 False False 0 0 0 0 0 0 0 0 0 2.9548002607889 0 0 0.00282273611850443 0.99884286044897 0.997873012135272 0.999444971558315 33 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2883C>T rrl_n.2883C>T 2 non_coding_transcript_exon_variant 1476540 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2124 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1537 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2887T>C rrl_n.2887T>C 2 non_coding_transcript_exon_variant 1476544 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.288T>A rrl_n.288T>A 2 non_coding_transcript_exon_variant 1473945 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1725 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1159 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2890C>T rrl_n.2890C>T 2 non_coding_transcript_exon_variant 1476547 NA 0 0 0 2 15 2047 15468 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.999031195504747 0.998402606935329 0.999457669301639 0.117647058823529 0.0145793168403025 0.36440916210125 NA NA NA 0 0 0.218019360910534 NA NA NA NA 1988 2386 False False 1.00752320468979 0.111713648797946 4.33756144038052 0 0 0.00180046780769359 0.999031195504747 0.998402606935329 0.999457669301639 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 14 1304 8628 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.998380004628558 0.99728341538717 0.999114059339894 0.0666666666666666 0.0016864302413527 0.319484566578303 NA NA NA 0 0 0.231635761650116 NA NA NA NA 1409 1774 False False 0 0 0 0 0 0 0 0.472611744084136 0.0111719189472547 3.11125356291235 0 0 0.00282489773306727 0.998380004628558 0.99728341538717 0.999114059339894 48 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.289A>T rrl_n.289A>T 2 non_coding_transcript_exon_variant 1473946 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1791 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1224 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2904C>T rrl_n.2904C>T 2 non_coding_transcript_exon_variant 1476561 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2910C>T rrl_n.2910C>T 2 non_coding_transcript_exon_variant 1476567 NA 0 0 0 2 16 2047 15467 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.998966608538396 0.99832237803854 0.999409215770894 0.111111111111111 0.0137512156643644 0.347120438608672 NA NA NA 0 0 0.205907214207822 NA NA NA NA 1950 2386 False False 0.944491939423546 0.105277647177081 4.02169809685859 0 0 0.00180046780769359 0.998966608538396 0.99832237803854 0.999409215770894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 15 1304 8627 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.998264290673455 0.997138824765365 0.999028221442365 0.0625 0.00158111172276588 0.302320738434531 NA NA NA 0 0 0.218019360910534 NA NA NA NA 1375 1774 False False 0 0 0 0 0 0 0 0.441053169734151 0.0104721174338976 2.8715850105769 0 0 0.00282489773306727 0.998264290673455 0.997138824765365 0.999028221442365 77 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2915G>A rrl_n.2915G>A 2 non_coding_transcript_exon_variant 1476572 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1905 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1331 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 22 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2915G>C rrl_n.2915G>C 2 non_coding_transcript_exon_variant 1476572 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2261 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1664 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2916A>C rrl_n.2916A>C 2 non_coding_transcript_exon_variant 1476573 NA 0 0 0 1 9 2048 15474 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999418717302848 0.998896832459985 0.999734167184357 0.1 0.00252857854446178 0.445016117028195 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1880 2386 False False 0.839518229166666 0.0191442481599193 6.06407759157277 0 0 0.00179958946453767 0.999418717302848 0.998896832459985 0.999734167184357 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 8 1304 8634 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999074288359176 0.998176798225858 0.999600261389848 0.111111111111111 0.00280913674659921 0.482496514917337 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1310 1774 False False 0 0 0 0 0 0 0 0.827645705521472 0.0186379987589414 6.18187193560828 0 0 0.00282489773306727 0.999074288359176 0.998176798225858 0.999600261389848 10 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2916A>T rrl_n.2916A>T 2 non_coding_transcript_exon_variant 1476573 NA 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2031 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1449 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 34 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.291C>A rrl_n.291C>A 2 non_coding_transcript_exon_variant 1473948 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2920T>G rrl_n.2920T>G 2 non_coding_transcript_exon_variant 1476577 NA 0 0 0 2 11 2047 15472 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.999289543370148 0.998729153244051 0.999645290955256 0.153846153846153 0.0192066719825284 0.454471055676557 NA NA NA 0 0 0.284914152918154 NA NA NA NA 2100 2386 False False 1.37425056623884 0.147939198576762 6.30344232307697 0 0 0.00180046780769359 0.999289543370148 0.998729153244051 0.999645290955256 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 9 1304 8633 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.998958574404073 0.998023974495813 0.999523686828456 0.1 0.00252857854446178 0.445016117028195 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1515 1774 False False 0 0 0 0 0 0 0 0.735599863667348 0.0167698879909291 5.31583775548636 0 0 0.00282489773306727 0.998958574404073 0.998023974495813 0.999523686828456 16 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2921C>A rrl_n.2921C>A 2 non_coding_transcript_exon_variant 1476578 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2926G>A rrl_n.2926G>A 2 non_coding_transcript_exon_variant 1476583 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2244 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1649 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2927C>T rrl_n.2927C>T 2 non_coding_transcript_exon_variant 1476584 NA 0 0 0 2 12 2047 15471 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.999224956403797 0.99864654661041 0.999599461575238 0.142857142857142 0.0177945154831915 0.428129160909698 NA NA NA 0 0 0.264648469397051 NA NA NA NA 1989 2386 False True 1.25964826575476 0.136849935012166 5.6648428486247 0 0 0.00180046780769359 0.999224956403797 0.99864654661041 0.999599461575238 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 1 11 1304 8631 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.998727146493867 0.997723657451287 0.999364430275444 0.0833333333333333 0.00210759323186022 0.384796165150944 NA NA NA 0 0 0.284914152918154 NA NA NA NA 1410 1774 False True 1 0 1 0 0 0 0 0.601715002788622 0.0139718970364074 4.14634229926157 0 0 0.00282489773306727 0.998727146493867 0.997723657451287 0.999364430275444 70 5) Not assoc w R New NotAwR yes 5 +Capreomycin rrl n.2928A>G rrl_n.2928A>G 2 non_coding_transcript_exon_variant 1476585 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2220 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1626 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 21 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.292C>T rrl_n.292C>T 2 non_coding_transcript_exon_variant 1473949 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2075 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2937C>T rrl_n.2937C>T 2 non_coding_transcript_exon_variant 1476594 NA 0 0 0 0 8 2049 15475 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1990 2386 False True 0 0 4.42794679154129 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 7 1305 8635 0 0 0.00282273611850443 0.999190002314279 0.998331811834773 0.999674278877205 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1411 1774 False True 1 0 1 0 0 0 0 0 0 4.59639609856608 0 0 0.00282273611850443 0.999190002314279 0.998331811834773 0.999674278877205 13 5) Not assoc w R New NotAwR yes 5 +Capreomycin rrl n.2938C>A rrl_n.2938C>A 2 non_coding_transcript_exon_variant 1476595 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2307 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1706 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2938C>T rrl_n.2938C>T 2 non_coding_transcript_exon_variant 1476595 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1836 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1268 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 5 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2939C>T rrl_n.2939C>T 2 non_coding_transcript_exon_variant 1476596 1 0 0 0 0 6 2049 15477 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1772 2386 False False 0 0 6.41986758323506 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1207 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.293G>T rrl_n.293G>T 2 non_coding_transcript_exon_variant 1473950 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2076 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1492 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2940G>A rrl_n.2940G>A 2 non_coding_transcript_exon_variant 1476597 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2032 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1450 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2943A>T rrl_n.2943A>T 2 non_coding_transcript_exon_variant 1476600 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2101 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1516 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2944G>A rrl_n.2944G>A 2 non_coding_transcript_exon_variant 1476601 NA 0 0 0 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1752 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1187 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2945G>A rrl_n.2945G>A 2 non_coding_transcript_exon_variant 1476602 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1968 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1390 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2945G>T rrl_n.2945G>T 2 non_coding_transcript_exon_variant 1476602 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1814 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1246 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2946G>A rrl_n.2946G>A 2 non_coding_transcript_exon_variant 1476603 NA 0 0 0 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 2171 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 5 1305 8637 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1580 1774 False False 0 0 0 0 0 0 0 0 0 7.23014561016525 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 9 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2950C>T rrl_n.2950C>T 2 non_coding_transcript_exon_variant 1476607 NA 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 2197 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1605 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 7 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2951C>A rrl_n.2951C>A 2 non_coding_transcript_exon_variant 1476608 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2156 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1567 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2951C>G rrl_n.2951C>G 2 non_coding_transcript_exon_variant 1476608 NA 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2010 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1428 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 8 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2951C>T rrl_n.2951C>T 2 non_coding_transcript_exon_variant 1476608 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2125 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1538 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2957A>G rrl_n.2957A>G 2 non_coding_transcript_exon_variant 1476614 NA 0 0 0 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1726 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1160 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.295G>T rrl_n.295G>T 2 non_coding_transcript_exon_variant 1473952 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2962C>T rrl_n.2962C>T 2 non_coding_transcript_exon_variant 1476619 NA 0 0 0 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1753 2386 False True 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1188 1774 False True 1 0 1 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 16 5) Not assoc w R New NotAwR yes 5 +Capreomycin rrl n.2964C>A rrl_n.2964C>A 2 non_coding_transcript_exon_variant 1476621 1 3 0 3 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 18.2956781909983 1 619.5 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1332 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2964C>T rrl_n.2964C>T 2 non_coding_transcript_exon_variant 1476621 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1773 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1208 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2967T>A rrl_n.2967T>A 2 non_coding_transcript_exon_variant 1476624 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1928 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1353 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2967T>G rrl_n.2967T>G 2 non_coding_transcript_exon_variant 1476624 NA 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2221 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1627 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2971T>A rrl_n.2971T>A 2 non_coding_transcript_exon_variant 1476628 NA 0 0 0 0 6 2049 15477 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 2033 2386 False False 0 0 6.41986758323506 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 5 1305 8637 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1451 1774 False False 0 0 0 0 0 0 0 0 0 7.23014561016525 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 10 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2972C>A rrl_n.2972C>A 2 non_coding_transcript_exon_variant 1476629 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2157 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1568 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 7 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2973A>G rrl_n.2973A>G 2 non_coding_transcript_exon_variant 1476630 NA 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 2172 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1581 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 6 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2980C>A rrl_n.2980C>A 2 non_coding_transcript_exon_variant 1476637 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2126 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1539 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 8 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2980C>G rrl_n.2980C>G 2 non_coding_transcript_exon_variant 1476637 NA 0 0 0 0 6 2049 15477 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 2034 2386 False False 0 0 6.41986758323506 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 5 1305 8637 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1452 1774 False False 0 0 0 0 0 0 0 0 0 7.23014561016525 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 8 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.2981C>T rrl_n.2981C>T 2 non_coding_transcript_exon_variant 1476638 NA 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1991 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1412 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.3004A>G rrl_n.3004A>G 2 non_coding_transcript_exon_variant 1476661 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1792 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1225 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 5 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.3005_3006dupCC rrl_n.3005_3006dupCC 2 non_coding_transcript_exon_variant 1476661 1 1 0 1 1 3 2048 15480 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999806239100949 0.999433853882399 0.999960040061829 0.25 0.00630946320970987 0.805879550316756 0 0 0.975 0 0 0.707598226178713 0 0 293.457028791419 1 619.5 2386 False False 2.51953125 0.047970285762596 31.379124977949 0 0 0.00179958946453767 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1226 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.3007T>C rrl_n.3007T>C 2 non_coding_transcript_exon_variant 1476664 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2308 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1707 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.3007T>G rrl_n.3007T>G 2 non_coding_transcript_exon_variant 1476664 1 1 0 1 0 14 2049 15469 0 0 0.00179871197794837 0.999095782471097 0.998483341560662 0.999505570487652 0 0 0.231635761650116 0 0 0.975 0 0 0.231635761650116 0 0 293.107005905184 1 194.5 2386 False False 0 0 2.27797115095248 0 0 0.00179871197794837 0.999095782471097 0.998483341560662 0.999505570487652 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 5 1305 8637 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 0 0 0.521823750104981 0 0 0.975 0 0 0.521823750104981 0 0 257.114061715895 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 7.23014561016525 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 42 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.3008T>A rrl_n.3008T>A 2 non_coding_transcript_exon_variant 1476665 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2198 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1606 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.3008T>C rrl_n.3008T>C 2 non_coding_transcript_exon_variant 1476665 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2077 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1493 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.3008T>G rrl_n.3008T>G 2 non_coding_transcript_exon_variant 1476665 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2245 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1650 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.3009C>T rrl_n.3009C>T 2 non_coding_transcript_exon_variant 1476666 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2173 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1582 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.3012C>T rrl_n.3012C>T 2 non_coding_transcript_exon_variant 1476669 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1837 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.3017T>C rrl_n.3017T>C 2 non_coding_transcript_exon_variant 1476674 NA 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2127 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1540 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 13 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.3018C>G rrl_n.3018C>G 2 non_coding_transcript_exon_variant 1476675 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1992 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1413 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.3022T>A rrl_n.3022T>A 2 non_coding_transcript_exon_variant 1476679 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1969 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1391 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.3022T>C rrl_n.3022T>C 2 non_coding_transcript_exon_variant 1476679 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1704 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1138 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.302T>C rrl_n.302T>C 2 non_coding_transcript_exon_variant 1473959 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.3033C>T rrl_n.3033C>T 2 non_coding_transcript_exon_variant 1476690 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 35.2688392655279 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.3035T>C rrl_n.3035T>C 2 non_coding_transcript_exon_variant 1476692 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1705 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1139 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.3037G>A rrl_n.3037G>A 2 non_coding_transcript_exon_variant 1476694 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2174 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1583 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.303T>C rrl_n.303T>C 2 non_coding_transcript_exon_variant 1473960 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.303T>G rrl_n.303T>G 2 non_coding_transcript_exon_variant 1473960 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2309 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.3042A>T rrl_n.3042A>T 2 non_coding_transcript_exon_variant 1476699 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2078 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1494 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.3053delC rrl_n.3053delC 2 non_coding_transcript_exon_variant 1476704 1 3 0 3 0 8 2049 15475 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 0 0 0.369416647552819 0 0 0.707598226178713 0 0 0.369416647552819 0 0 18.2921463704185 1 194.5 2386 False False 0 0 4.42794679154129 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 257.173353425001 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 13 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.3053dupC rrl_n.3053dupC 2 non_coding_transcript_exon_variant 1476704 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.3059A>C rrl_n.3059A>C 2 non_coding_transcript_exon_variant 1476716 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1838 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1269 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.3064G>A rrl_n.3064G>A 2 non_coding_transcript_exon_variant 1476721 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.3068C>T rrl_n.3068C>T 2 non_coding_transcript_exon_variant 1476725 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.3093T>G rrl_n.3093T>G 2 non_coding_transcript_exon_variant 1476750 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.3094A>G rrl_n.3094A>G 2 non_coding_transcript_exon_variant 1476751 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.3119C>T rrl_n.3119C>T 2 non_coding_transcript_exon_variant 1476776 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2175 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1584 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.3136A>T rrl_n.3136A>T 2 non_coding_transcript_exon_variant 1476793 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.328A>G rrl_n.328A>G 2 non_coding_transcript_exon_variant 1473985 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2363 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.335A>C rrl_n.335A>C 2 non_coding_transcript_exon_variant 1473992 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.344C>T rrl_n.344C>T 2 non_coding_transcript_exon_variant 1474001 NA 0 0 0 86 646 1963 14837 0.0419716935090287 0.0337065663105309 0.0515772828768323 0.958276819737776 0.955007671415607 0.961372330705986 0.117486338797814 0.0950561553772061 0.143050669034902 NA NA NA 0 0 0.00569406671195672 NA NA NA NA 2176 2386 False True 1.00621718510714 0.790011063333133 1.26848845579336 0 0 0.00187744041969374 0.958276819737776 0.955007671415607 0.961372330705986 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 61 447 1244 8195 0.046743295019157 0.0359405598675541 0.0596416239031665 0.948275862068965 0.943395349545913 0.952851256835325 0.12007874015748 0.0931078329988739 0.151561628780579 NA NA NA 0 0 0.00821856812317534 NA NA NA NA 1585 1774 False True 0 1 1 0 0 0 0 0.898981779206859 0.671823097850865 1.18549823537945 0 0 0.00296094491205568 0.948275862068965 0.943395349545913 0.952851256835325 1934 5) Not assoc w R New NotAwR yes 5 +Capreomycin rrl n.354G>A rrl_n.354G>A 2 non_coding_transcript_exon_variant 1474011 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 35.2688392655279 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.367G>T rrl_n.367G>T 2 non_coding_transcript_exon_variant 1474024 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2222 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.387C>T rrl_n.387C>T 2 non_coding_transcript_exon_variant 1474044 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1754 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1189 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.388C>T rrl_n.388C>T 2 non_coding_transcript_exon_variant 1474045 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2346 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1740 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.38A>G rrl_n.38A>G 2 non_coding_transcript_exon_variant 1473695 1 3 0 3 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 18.2980327465689 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 16.0319456706962 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.396G>A rrl_n.396G>A 2 non_coding_transcript_exon_variant 1474053 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1993 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1414 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.397T>C rrl_n.397T>C 2 non_coding_transcript_exon_variant 1474054 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2246 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1651 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.-39G>A rrl_n.-39G>A 2 upstream_gene_variant 1473619 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.39T>C rrl_n.39T>C 2 non_coding_transcript_exon_variant 1473696 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1994 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1415 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 6 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.3G>A rrl_n.3G>A 2 non_coding_transcript_exon_variant 1473660 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2128 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.407A>T rrl_n.407A>T 2 non_coding_transcript_exon_variant 1474064 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2129 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1541 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.408C>G rrl_n.408C>G 2 non_coding_transcript_exon_variant 1474065 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2286 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1686 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.408C>T rrl_n.408C>T 2 non_coding_transcript_exon_variant 1474065 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.40C>T rrl_n.40C>T 2 non_coding_transcript_exon_variant 1473697 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2011 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1429 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.417C>T rrl_n.417C>T 2 non_coding_transcript_exon_variant 1474074 1 0 0 0 1 2 2048 15481 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999870826067299 0.999533458063883 0.999984356054634 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1727 2386 False False 3.779541015625 0.0640320806562028 72.4657839845296 0 0 0.00179958946453767 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 2 1304 8640 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999768572089794 0.999164255486522 0.999971971777513 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1161 1774 False False 0 0 0 0 0 0 0 3.31288343558282 0.056110603773561 63.7302235362974 0 0 0.00282489773306727 0.999768572089794 0.999164255486522 0.999971971777513 5 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.426C>T rrl_n.426C>T 2 non_coding_transcript_exon_variant 1474083 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1686 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1124 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.42A>G rrl_n.42A>G 2 non_coding_transcript_exon_variant 1473699 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1728 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1162 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.432C>T rrl_n.432C>T 2 non_coding_transcript_exon_variant 1474089 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2102 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1517 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.435G>T rrl_n.435G>T 2 non_coding_transcript_exon_variant 1474092 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.436G>A rrl_n.436G>A 2 non_coding_transcript_exon_variant 1474093 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1906 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1333 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.-43G>C rrl_n.-43G>C 2 upstream_gene_variant 1473615 1 3 0 3 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 18.2968554679321 1 619.5 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.447G>A rrl_n.447G>A 2 non_coding_transcript_exon_variant 1474104 1 1 0 1 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 293.33332543886 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.448T>C rrl_n.448T>C 2 non_coding_transcript_exon_variant 1474105 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2247 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.461G>T rrl_n.461G>T 2 non_coding_transcript_exon_variant 1474118 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2130 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1542 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.471G>T rrl_n.471G>T 2 non_coding_transcript_exon_variant 1474128 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1995 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.473C>T rrl_n.473C>T 2 non_coding_transcript_exon_variant 1474130 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1815 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1247 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 9 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.478G>A rrl_n.478G>A 2 non_coding_transcript_exon_variant 1474135 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2012 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1430 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.482C>G rrl_n.482C>G 2 non_coding_transcript_exon_variant 1474139 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.483C>T rrl_n.483C>T 2 non_coding_transcript_exon_variant 1474140 NA 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 2177 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1586 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 13 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.494C>T rrl_n.494C>T 2 non_coding_transcript_exon_variant 1474151 NA 0 0 0 0 6 2049 15477 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 2054 2386 False False 0 0 6.41986758323506 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 6 1305 8636 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1473 1774 False False 0 0 0 0 0 0 0 0 0 5.62683462374212 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 20 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.496C>G rrl_n.496C>G 2 non_coding_transcript_exon_variant 1474153 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2079 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1495 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.-49G>C rrl_n.-49G>C 2 upstream_gene_variant 1473609 1 8 0 8 0 10 2049 15473 0 0 0.00179871197794837 0.999354130336498 0.998812544515655 0.999690238326549 0 0 0.30849710781876 0 0 0.369416647552819 0 0 0.30849710781876 0 0 4.42737458613668 0.608191125583359 162.5 2386 False False 0 0 3.37173073063401 0 0 0.00179871197794837 0.999354130336498 0.998812544515655 0.999690238326549 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 10.0364048825129 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 27 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.-4G>C rrl_n.-4G>C 2 upstream_gene_variant 1473654 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2310 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.502C>G rrl_n.502C>G 2 non_coding_transcript_exon_variant 1474159 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.509G>C rrl_n.509G>C 2 non_coding_transcript_exon_variant 1474166 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1793 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1227 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.50T>A rrl_n.50T>A 2 non_coding_transcript_exon_variant 1473707 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2035 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1453 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.517A>G rrl_n.517A>G 2 non_coding_transcript_exon_variant 1474174 NA 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1687 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1125 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 5 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.519A>G rrl_n.519A>G 2 non_coding_transcript_exon_variant 1474176 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1774 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1209 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.522C>T rrl_n.522C>T 2 non_coding_transcript_exon_variant 1474179 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2364 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1757 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.524C>T rrl_n.524C>T 2 non_coding_transcript_exon_variant 1474181 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1970 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1392 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.525C>T rrl_n.525C>T 2 non_coding_transcript_exon_variant 1474182 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1839 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1270 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.526T>C rrl_n.526T>C 2 non_coding_transcript_exon_variant 1474183 NA 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1907 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1334 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 14 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.527C>T rrl_n.527C>T 2 non_coding_transcript_exon_variant 1474184 NA 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2287 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1687 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 29 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.528G>A rrl_n.528G>A 2 non_coding_transcript_exon_variant 1474185 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2080 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1496 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 11 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.529A>G rrl_n.529A>G 2 non_coding_transcript_exon_variant 1474186 NA 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1775 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1210 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 9 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.540C>T rrl_n.540C>T 2 non_coding_transcript_exon_variant 1474197 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1865 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1296 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 8 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.544T>C rrl_n.544T>C 2 non_coding_transcript_exon_variant 1474201 1 5 0 5 0 8 2049 15475 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 0 0 0.369416647552819 0 0 0.521823750104981 0 0 0.369416647552819 0 0 8.24736096464061 1 619.5 2386 False False 0 0 4.42794679154129 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 35.2647591017504 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 17 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.545delT rrl_n.545delT 2 non_coding_transcript_exon_variant 1474200 NA 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2055 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1474 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.561T>A rrl_n.561T>A 2 non_coding_transcript_exon_variant 1474218 NA 0 0 0 2 14 2047 15469 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.999095782471097 0.998483341560662 0.999505570487652 0.125 0.0155136038154138 0.383476236849263 NA NA NA 0 0 0.231635761650116 NA NA NA NA 2223 2386 False False 1.07955893642263 0.118984769392524 4.70616521734574 0 0 0.00180046780769359 0.999095782471097 0.998483341560662 0.999505570487652 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 13 1304 8629 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.998495718583661 0.997429006709305 0.999198798037271 0.0714285714285714 0.00180678065912538 0.338684489931821 NA NA NA 0 0 0.24705263800047 NA NA NA NA 1628 1774 False False 0 0 0 0 0 0 0 0.509025483718735 0.0119717871431919 3.3945001710655 0 0 0.00282489773306727 0.998495718583661 0.997429006709305 0.999198798037271 108 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.565G>T rrl_n.565G>T 2 non_coding_transcript_exon_variant 1474222 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.571T>A rrl_n.571T>A 2 non_coding_transcript_exon_variant 1474228 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2329 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1724 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 15 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.571T>C rrl_n.571T>C 2 non_coding_transcript_exon_variant 1474228 NA 0 0 0 2 8 2047 15475 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.999483304269198 0.998982158652985 0.999776901906193 0.2 0.0252107263268333 0.556095462307641 NA NA NA 0 0 0.369416647552819 NA NA NA NA 2036 2386 False False 1.88996091841719 0.195371049431526 9.48109495396585 0 0 0.00180046780769359 0.999483304269198 0.998982158652985 0.999776901906193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 7 1304 8635 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999190002314279 0.998331811834773 0.999674278877205 0.125 0.0031597235312519 0.526509670875206 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1454 1774 False False 0 0 0 0 0 0 0 0.945990359333917 0.0209738740409183 7.37396279411377 0 0 0.00282489773306727 0.999190002314279 0.998331811834773 0.999674278877205 66 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.579G>A rrl_n.579G>A 2 non_coding_transcript_exon_variant 1474236 NA 0 0 0 2 7 2047 15476 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.999547891235548 0.999068706427379 0.999818210125054 0.222222222222222 0.0281449734778982 0.600093573716312 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1755 2386 False False 2.16009491241538 0.218788540583066 11.351113176461 0 0 0.00180046780769359 0.999547891235548 0.999068706427379 0.999818210125054 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 6 1304 8636 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999305716269382 0.998489453757575 0.999745168847445 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1190 1774 False False 0 0 0 0 0 0 0 1.10378323108384 0.0239783465953148 9.10896322125085 0 0 0.00282489773306727 0.999305716269382 0.998489453757575 0.999745168847445 25 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.592G>T rrl_n.592G>T 2 non_coding_transcript_exon_variant 1474249 NA 0 0 0 1 11 2048 15472 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999289543370148 0.998729153244051 0.999645290955256 0.0833333333333333 0.00210759323186022 0.384796165150944 NA NA NA 0 0 0.284914152918154 NA NA NA NA 2199 2386 False False 0.686789772727272 0.0159480966540523 4.72976907145362 0 0 0.00179958946453767 0.999289543370148 0.998729153244051 0.999645290955256 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 11 1304 8631 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.998727146493867 0.997723657451287 0.999364430275444 0.0833333333333333 0.00210759323186022 0.384796165150944 NA NA NA 0 0 0.284914152918154 NA NA NA NA 1607 1774 False False 0 0 0 0 0 0 0 0.601715002788622 0.0139718970364074 4.14634229926157 0 0 0.00282489773306727 0.998727146493867 0.997723657451287 0.999364430275444 127 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.595T>A rrl_n.595T>A 2 non_coding_transcript_exon_variant 1474252 NA 0 0 0 2 8 2047 15475 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.999483304269198 0.998982158652985 0.999776901906193 0.2 0.0252107263268333 0.556095462307641 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1971 2386 False False 1.88996091841719 0.195371049431526 9.48109495396585 0 0 0.00180046780769359 0.999483304269198 0.998982158652985 0.999776901906193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 7 1304 8635 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999190002314279 0.998331811834773 0.999674278877205 0.125 0.0031597235312519 0.526509670875206 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1393 1774 False False 0 0 0 0 0 0 0 0.945990359333917 0.0209738740409183 7.37396279411377 0 0 0.00282489773306727 0.999190002314279 0.998331811834773 0.999674278877205 91 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.596A>T rrl_n.596A>T 2 non_coding_transcript_exon_variant 1474253 NA 0 0 0 2 6 2047 15477 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.999612478201898 0.999156720468893 0.999857773477374 0.25 0.0318540262499442 0.650855794412824 NA NA NA 0 0 0.4592581264399 NA NA NA NA 2013 2386 False False 2.52027357107962 0.248589653329624 14.1023767968479 0 0 0.00180046780769359 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 5 1304 8637 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999421430224485 0.99865033199523 0.999812114132187 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1431 1774 False False 0 0 0 0 0 0 0 1.32469325153374 0.0279864197449639 11.8514948120722 0 0 0.00282489773306727 0.999421430224485 0.99865033199523 0.999812114132187 18 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.597C>T rrl_n.597C>T 2 non_coding_transcript_exon_variant 1474254 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.606G>A rrl_n.606G>A 2 non_coding_transcript_exon_variant 1474263 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1776 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1211 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.609T>C rrl_n.609T>C 2 non_coding_transcript_exon_variant 1474266 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2081 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1497 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.60G>A rrl_n.60G>A 2 non_coding_transcript_exon_variant 1473717 1 1 0 1 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 293.314465539138 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1758 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.60G>T rrl_n.60G>T 2 non_coding_transcript_exon_variant 1473717 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2178 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1587 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.612C>T rrl_n.612C>T 2 non_coding_transcript_exon_variant 1474269 1 2 0 2 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 40.2315677803598 1 619.5 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1741 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 41 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.625G>A rrl_n.625G>A 2 non_coding_transcript_exon_variant 1474282 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2131 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1543 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.627G>T rrl_n.627G>T 2 non_coding_transcript_exon_variant 1474284 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1881 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.634_653delTTTCCTCTCCGGAGGAGGGTinsCGTGG rrl_n.634_653delTTTCCTCTCCGGAGGAGGGTinsCGTGG 2 non_coding_transcript_exon_variant 1474291 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1729 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1163 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.635_653delTTCCTCTCCGGAGGAGGGTinsCGTGGTGG rrl_n.635_653delTTCCTCTCCGGAGGAGGGTinsCGTGGTGG 2 non_coding_transcript_exon_variant 1474292 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2347 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1742 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.637C>G rrl_n.637C>G 2 non_coding_transcript_exon_variant 1474294 NA 0 0 0 3 77 2046 15406 0.00146412884333821 0.000302040401839334 0.00427278776332334 0.995026803591035 0.993788222122314 0.996073297378689 0.0375 0.00780118726571669 0.105701985016508 NA NA NA 0 0 0.046778068160404 NA NA NA NA 1730 2386 False True 0.293369387211029 0.0591582469164055 0.891369902767681 0 0 0.00180134700867096 0.995026803591035 0.993788222122314 0.996073297378689 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 2 61 1303 8581 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.992941448738718 0.990942110331448 0.994596590666785 0.0317460317460317 0.0038679824964188 0.11001937340888 NA NA NA 0 0 0.0586812239322925 NA NA NA NA 1164 1774 False True 0 1 1 0 0 0 0 0.215920385491237 0.025540364625919 0.815940710068735 0 0 0.00282706266083767 0.992941448738718 0.990942110331448 0.994596590666785 257 5) Not assoc w R New NotAwR yes 5 +Capreomycin rrl n.651G>T rrl_n.651G>T 2 non_coding_transcript_exon_variant 1474308 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.669T>A rrl_n.669T>A 2 non_coding_transcript_exon_variant 1474326 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1882 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1311 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.673A>T rrl_n.673A>T 2 non_coding_transcript_exon_variant 1474330 NA 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2348 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1743 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 21 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.686C>T rrl_n.686C>T 2 non_coding_transcript_exon_variant 1474343 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.691C>T rrl_n.691C>T 2 non_coding_transcript_exon_variant 1474348 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2132 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1544 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 20 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.694G>C rrl_n.694G>C 2 non_coding_transcript_exon_variant 1474351 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1883 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1312 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 9 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.694G>T rrl_n.694G>T 2 non_coding_transcript_exon_variant 1474351 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2365 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1759 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 24 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.696A>G rrl_n.696A>G 2 non_coding_transcript_exon_variant 1474353 NA 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1731 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1165 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 16 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.698A>G rrl_n.698A>G 2 non_coding_transcript_exon_variant 1474355 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2200 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1608 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 7 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.699T>C rrl_n.699T>C 2 non_coding_transcript_exon_variant 1474356 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2366 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1760 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 17 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.702C>G rrl_n.702C>G 2 non_coding_transcript_exon_variant 1474359 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2288 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1688 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 7 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.705A>G rrl_n.705A>G 2 non_coding_transcript_exon_variant 1474362 NA 0 0 0 0 6 2049 15477 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1908 2386 False False 0 0 6.41986758323506 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 6 1305 8636 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1335 1774 False False 0 0 0 0 0 0 0 0 0 5.62683462374212 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 34 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.717T>G rrl_n.717T>G 2 non_coding_transcript_exon_variant 1474374 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1909 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1336 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.718dupG rrl_n.718dupG 2 non_coding_transcript_exon_variant 1474374 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2179 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1588 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.723G>A rrl_n.723G>A 2 non_coding_transcript_exon_variant 1474380 1 3 0 3 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 18.2980327465689 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.730C>T rrl_n.730C>T 2 non_coding_transcript_exon_variant 1474387 NA 0 0 0 0 6 2049 15477 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 2367 2386 False False 0 0 6.41986758323506 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 5 1305 8637 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1761 1774 False False 0 0 0 0 0 0 0 0 0 7.23014561016525 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 43 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.733C>T rrl_n.733C>T 2 non_coding_transcript_exon_variant 1474390 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.745T>C rrl_n.745T>C 2 non_coding_transcript_exon_variant 1474402 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2158 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1569 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 7 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.74T>A rrl_n.74T>A 2 non_coding_transcript_exon_variant 1473731 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1866 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1297 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.756_764delACCCACACGinsTATC rrl_n.756_764delACCCACACGinsTATC 2 non_coding_transcript_exon_variant 1474413 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2082 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1498 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.756_781delACCCACACGCGCATACGCGCGTGTGAinsCCC rrl_n.756_781delACCCACACGCGCATACGCGCGTGTGAinsCCC 2 non_coding_transcript_exon_variant 1474413 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1756 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1191 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.757C>G rrl_n.757C>G 2 non_coding_transcript_exon_variant 1474414 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.758C>T rrl_n.758C>T 2 non_coding_transcript_exon_variant 1474415 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.760A>G rrl_n.760A>G 2 non_coding_transcript_exon_variant 1474417 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.781_782delAA rrl_n.781_782delAA 2 non_coding_transcript_exon_variant 1474437 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2248 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1652 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.781A>G rrl_n.781A>G 2 non_coding_transcript_exon_variant 1474438 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1794 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1228 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.782dupA rrl_n.782dupA 2 non_coding_transcript_exon_variant 1474437 1 3 0 3 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 18.2980327465689 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.784A>G rrl_n.784A>G 2 non_coding_transcript_exon_variant 1474441 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2289 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.787G>A rrl_n.787G>A 2 non_coding_transcript_exon_variant 1474444 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.789C>T rrl_n.789C>T 2 non_coding_transcript_exon_variant 1474446 1 1 0 1 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 293.33332543886 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1689 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.791T>C rrl_n.791T>C 2 non_coding_transcript_exon_variant 1474448 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1996 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1416 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.793T>A rrl_n.793T>A 2 non_coding_transcript_exon_variant 1474450 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2201 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1609 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 8 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.795C>T rrl_n.795C>T 2 non_coding_transcript_exon_variant 1474452 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.797G>A rrl_n.797G>A 2 non_coding_transcript_exon_variant 1474454 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1910 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1337 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 13 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.798G>A rrl_n.798G>A 2 non_coding_transcript_exon_variant 1474455 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.807C>T rrl_n.807C>T 2 non_coding_transcript_exon_variant 1474464 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 16 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.809G>A rrl_n.809G>A 2 non_coding_transcript_exon_variant 1474466 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.825G>T rrl_n.825G>T 2 non_coding_transcript_exon_variant 1474482 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2349 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.831G>T rrl_n.831G>T 2 non_coding_transcript_exon_variant 1474488 NA 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1757 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1192 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 27 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.837C>T rrl_n.837C>T 2 non_coding_transcript_exon_variant 1474494 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1929 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.838G>T rrl_n.838G>T 2 non_coding_transcript_exon_variant 1474495 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1951 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.839C>A rrl_n.839C>A 2 non_coding_transcript_exon_variant 1474496 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2133 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1545 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 15 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.839C>G rrl_n.839C>G 2 non_coding_transcript_exon_variant 1474496 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1911 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1338 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.840G>A rrl_n.840G>A 2 non_coding_transcript_exon_variant 1474497 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2180 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.840G>C rrl_n.840G>C 2 non_coding_transcript_exon_variant 1474497 NA 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2224 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1629 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 18 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.846G>C rrl_n.846G>C 2 non_coding_transcript_exon_variant 1474503 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1912 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.848C>G rrl_n.848C>G 2 non_coding_transcript_exon_variant 1474505 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2202 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1610 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.849C>G rrl_n.849C>G 2 non_coding_transcript_exon_variant 1474506 NA 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1840 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1271 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 20 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.849C>T rrl_n.849C>T 2 non_coding_transcript_exon_variant 1474506 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2083 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.850G>C rrl_n.850G>C 2 non_coding_transcript_exon_variant 1474507 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2084 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1499 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.850G>T rrl_n.850G>T 2 non_coding_transcript_exon_variant 1474507 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2085 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1500 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 20 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.851C>A rrl_n.851C>A 2 non_coding_transcript_exon_variant 1474508 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2368 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.851C>T rrl_n.851C>T 2 non_coding_transcript_exon_variant 1474508 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2134 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1546 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 7 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.852G>A rrl_n.852G>A 2 non_coding_transcript_exon_variant 1474509 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1884 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.859C>A rrl_n.859C>A 2 non_coding_transcript_exon_variant 1474516 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2159 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1570 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 25 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.860C>T rrl_n.860C>T 2 non_coding_transcript_exon_variant 1474517 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1930 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1354 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.866C>T rrl_n.866C>T 2 non_coding_transcript_exon_variant 1474523 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.870T>G rrl_n.870T>G 2 non_coding_transcript_exon_variant 1474527 NA 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2181 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1589 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.871T>C rrl_n.871T>C 2 non_coding_transcript_exon_variant 1474528 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2135 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.873G>C rrl_n.873G>C 2 non_coding_transcript_exon_variant 1474530 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2350 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1744 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.873G>T rrl_n.873G>T 2 non_coding_transcript_exon_variant 1474530 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2103 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1518 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.880G>A rrl_n.880G>A 2 non_coding_transcript_exon_variant 1474537 NA 0 0 0 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 2014 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1432 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 31 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.882C>A rrl_n.882C>A 2 non_coding_transcript_exon_variant 1474539 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1795 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1229 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.882C>G rrl_n.882C>G 2 non_coding_transcript_exon_variant 1474539 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2369 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1762 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.885A>C rrl_n.885A>C 2 non_coding_transcript_exon_variant 1474542 NA 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1885 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1313 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.889G>A rrl_n.889G>A 2 non_coding_transcript_exon_variant 1474546 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.894G>C rrl_n.894G>C 2 non_coding_transcript_exon_variant 1474551 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1867 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1298 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.895C>G rrl_n.895C>G 2 non_coding_transcript_exon_variant 1474552 NA 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2104 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1519 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.896T>C rrl_n.896T>C 2 non_coding_transcript_exon_variant 1474553 1 3 0 3 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 18.2980327465689 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.898T>G rrl_n.898T>G 2 non_coding_transcript_exon_variant 1474555 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1886 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1314 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.89T>C rrl_n.89T>C 2 non_coding_transcript_exon_variant 1473746 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1796 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1230 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.901G>A rrl_n.901G>A 2 non_coding_transcript_exon_variant 1474558 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2370 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1763 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 15 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.901G>C rrl_n.901G>C 2 non_coding_transcript_exon_variant 1474558 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 6 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.901G>T rrl_n.901G>T 2 non_coding_transcript_exon_variant 1474558 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2225 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1630 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.905G>C rrl_n.905G>C 2 non_coding_transcript_exon_variant 1474562 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2290 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1690 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.906G>A rrl_n.906G>A 2 non_coding_transcript_exon_variant 1474563 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.908T>A rrl_n.908T>A 2 non_coding_transcript_exon_variant 1474565 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2226 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1631 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.913G>T rrl_n.913G>T 2 non_coding_transcript_exon_variant 1474570 NA 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2105 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1520 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.914G>A rrl_n.914G>A 2 non_coding_transcript_exon_variant 1474571 1 2 0 2 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 0 0 0.841886116991581 0 0 0.521823750104981 0 0 40.2289720864225 1 619.5 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 257.143707584236 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 20 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.914G>T rrl_n.914G>T 2 non_coding_transcript_exon_variant 1474571 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1931 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1355 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.921A>G rrl_n.921A>G 2 non_coding_transcript_exon_variant 1474578 NA 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2330 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1725 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 5 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.924C>G rrl_n.924C>G 2 non_coding_transcript_exon_variant 1474581 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.925T>C rrl_n.925T>C 2 non_coding_transcript_exon_variant 1474582 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1997 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.926C>T rrl_n.926C>T 2 non_coding_transcript_exon_variant 1474583 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2056 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 12 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.927C>G rrl_n.927C>G 2 non_coding_transcript_exon_variant 1474584 NA 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2136 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1547 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 17 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.929T>A rrl_n.929T>A 2 non_coding_transcript_exon_variant 1474586 NA 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2015 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1433 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 13 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.929T>C rrl_n.929T>C 2 non_coding_transcript_exon_variant 1474586 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.944C>T rrl_n.944C>T 2 non_coding_transcript_exon_variant 1474601 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2037 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.947G>A rrl_n.947G>A 2 non_coding_transcript_exon_variant 1474604 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.969T>C rrl_n.969T>C 2 non_coding_transcript_exon_variant 1474626 NA 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1816 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1248 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 6 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.970G>A rrl_n.970G>A 2 non_coding_transcript_exon_variant 1474627 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1841 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1272 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.972G>A rrl_n.972G>A 2 non_coding_transcript_exon_variant 1474629 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1998 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1417 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.975G>T rrl_n.975G>T 2 non_coding_transcript_exon_variant 1474632 NA 0 0 0 0 6 2049 15477 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 2262 2386 False False 0 0 6.41986758323506 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 6 1305 8636 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1665 1774 False False 0 0 0 0 0 0 0 0 0 5.62683462374212 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 17 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.979A>C rrl_n.979A>C 2 non_coding_transcript_exon_variant 1474636 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1932 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1356 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 9 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.979A>T rrl_n.979A>T 2 non_coding_transcript_exon_variant 1474636 NA 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1732 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1166 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 16 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.980C>G rrl_n.980C>G 2 non_coding_transcript_exon_variant 1474637 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2331 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1726 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.980C>T rrl_n.980C>T 2 non_coding_transcript_exon_variant 1474637 NA 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2086 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1501 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 18 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.981C>G rrl_n.981C>G 2 non_coding_transcript_exon_variant 1474638 NA 0 0 0 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 2263 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 5 1305 8637 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1666 1774 False False 0 0 0 0 0 0 0 0 0 7.23014561016525 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 17 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.982G>A rrl_n.982G>A 2 non_coding_transcript_exon_variant 1474639 1 18 0 18 0 24 2049 15459 0 0 0.00179871197794837 0.998449912807595 0.997694465417801 0.999006585264568 0 0 0.142473597722525 0 0 0.185301968137852 0 0 0.142473597722525 0 0 1.71760627389655 0.257504189164284 134 2386 False False 0 0 1.25473260291809 0 0 0.00179871197794837 0.998449912807595 0.997694465417801 0.999006585264568 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 13 0 13 0 19 1305 8623 0 0 0.00282273611850443 0.997801434853043 0.996568788084241 0.998675817295743 0 0 0.176466911806965 0 0 0.24705263800047 0 0 0.176466911806965 0 0 2.17128451777426 0.39857233920318 101 1774 False False 0 0 0 0 0 0 0 0 0 1.41804759493913 0 0 0.00282273611850443 0.997801434853043 0.996568788084241 0.998675817295743 408 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.982G>C rrl_n.982G>C 2 non_coding_transcript_exon_variant 1474639 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2137 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1548 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 16 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.982G>T rrl_n.982G>T 2 non_coding_transcript_exon_variant 1474639 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1842 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1273 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.983C>T rrl_n.983C>T 2 non_coding_transcript_exon_variant 1474640 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2227 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1632 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 5 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.986A>G rrl_n.986A>G 2 non_coding_transcript_exon_variant 1474643 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1777 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1212 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrl n.99G>T rrl_n.99G>T 2 non_coding_transcript_exon_variant 1473756 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2016 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1434 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1000G>A rrs_n.1000G>A 1 non_coding_transcript_exon_variant 1472845 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1385 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 914 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1001C>A rrs_n.1001C>A 1 non_coding_transcript_exon_variant 1472846 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1376 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 907 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1001C>G rrs_n.1001C>G 1 non_coding_transcript_exon_variant 1472846 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.1001C>T rrs_n.1001C>T 1 non_coding_transcript_exon_variant 1472846 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1166 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 700 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1002G>A rrs_n.1002G>A 1 non_coding_transcript_exon_variant 1472847 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1181 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 715 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1002G>C rrs_n.1002G>C 1 non_coding_transcript_exon_variant 1472847 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1344 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 874 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1002G>T rrs_n.1002G>T 1 non_coding_transcript_exon_variant 1472847 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1363 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 893 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1003T>A rrs_n.1003T>A 1 non_coding_transcript_exon_variant 1472848 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1190 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 723 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1003T>C rrs_n.1003T>C 1 non_coding_transcript_exon_variant 1472848 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1191 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 724 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1004C>G rrs_n.1004C>G 1 non_coding_transcript_exon_variant 1472849 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1402 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 931 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1005T>C rrs_n.1005T>C 1 non_coding_transcript_exon_variant 1472850 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1307 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 839 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.-101_-100insG rrs_n.-101_-100insG 1 upstream_gene_variant 1471745 1 5 1 4 1 4 2048 15479 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999741652134599 0.999338660174897 0.999929604559257 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 1.8895263671875 0.0383494517213545 19.1050373764475 0.462862503415467 151 2386 False False 1.8895263671875 0.0383494517213545 19.1050373764475 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 1 3 1 3 1304 8639 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999652858134691 0.998985842622235 0.999928405279598 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 2.20833333333333 0.0420336930075031 27.526218938507 0.430296342468493 103 1774 False False 0 0 0 0 0 0 0 2.20833333333333 0.0420336930075031 27.526218938507 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999652858134691 0.998985842622235 0.999928405279598 5 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1010_1011insC rrs_n.1010_1011insC 1 non_coding_transcript_exon_variant 1472855 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1012A>G rrs_n.1012A>G 1 non_coding_transcript_exon_variant 1472857 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1218 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 750 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 21 3) Uncertain significance No change no 1 +Capreomycin rrs n.1013G>T rrs_n.1013G>T 1 non_coding_transcript_exon_variant 1472858 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1268 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 801 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1014_1015insA rrs_n.1014_1015insA 1 non_coding_transcript_exon_variant 1472859 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1167 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 701 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1014G>T rrs_n.1014G>T 1 non_coding_transcript_exon_variant 1472859 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1227 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 759 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1015C>G rrs_n.1015C>G 1 non_coding_transcript_exon_variant 1472860 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1067 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 609 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1015C>T rrs_n.1015C>T 1 non_coding_transcript_exon_variant 1472860 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1057 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 599 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1016G>A rrs_n.1016G>A 1 non_coding_transcript_exon_variant 1472861 1 1 0 1 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 293.33332543886 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 600 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.1016G>C rrs_n.1016G>C 1 non_coding_transcript_exon_variant 1472861 1 1 0 1 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 293.314465539138 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Capreomycin rrs n.1016G>T rrs_n.1016G>T 1 non_coding_transcript_exon_variant 1472861 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Capreomycin rrs n.1017T>C rrs_n.1017T>C 1 non_coding_transcript_exon_variant 1472862 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1058 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 601 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1018T>C rrs_n.1018T>C 1 non_coding_transcript_exon_variant 1472863 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1345 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 875 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1021C>T rrs_n.1021C>T 1 non_coding_transcript_exon_variant 1472866 1 8 0 8 0 10 2049 15473 0 0 0.00179871197794837 0.999354130336498 0.998812544515655 0.999690238326549 0 0 0.30849710781876 0 0 0.369416647552819 0 0 0.30849710781876 0 0 4.42737458613668 0.608191125583359 162.5 2386 False False 0 0 3.37173073063401 0 0 0.00179871197794837 0.999354130336498 0.998812544515655 0.999690238326549 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 257.173353425001 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 6 3) Uncertain significance No change no 1 +Capreomycin rrs n.1022_1032delTTGTGGCCTGTinsCTTCGGGGGACAAA rrs_n.1022_1032delTTGTGGCCTGTinsCTTCGGGGGACAAA 1 non_coding_transcript_exon_variant 1472867 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1269 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1022_1032delTTGTGGCCTGTinsCTTCGGGGGCAGA rrs_n.1022_1032delTTGTGGCCTGTinsCTTCGGGGGCAGA 1 non_coding_transcript_exon_variant 1472867 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1317 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1022T>G rrs_n.1022T>G 1 non_coding_transcript_exon_variant 1472867 1 3 0 3 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 18.2980327465689 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 16.0319456706962 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 6 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1024_1032delGTGGCCTGTinsCGGGGGCAGA rrs_n.1024_1032delGTGGCCTGTinsCGGGGGCAGA 1 non_coding_transcript_exon_variant 1472869 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1308 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 840 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1028C>A rrs_n.1028C>A 1 non_coding_transcript_exon_variant 1472873 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.1028C>T rrs_n.1028C>T 1 non_coding_transcript_exon_variant 1472873 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1386 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 915 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1030T>G rrs_n.1030T>G 1 non_coding_transcript_exon_variant 1472875 1 1 0 1 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 293.295605628248 1 619.5 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 894 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 2 3) Uncertain significance No change no 1 +Capreomycin rrs n.1035_1036insA rrs_n.1035_1036insA 1 non_coding_transcript_exon_variant 1472880 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1100 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 640 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1035G>A rrs_n.1035G>A 1 non_coding_transcript_exon_variant 1472880 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1129 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 669 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1042G>C rrs_n.1042G>C 1 non_coding_transcript_exon_variant 1472887 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1168 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 702 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 26 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1050C>T rrs_n.1050C>T 1 non_coding_transcript_exon_variant 1472895 0 0 0 0 3 38 2046 15445 0.00146412884333821 0.000302040401839334 0.00427278776332334 0.997545695278692 0.996632815663458 0.998262620434091 0.073170731707317 0.0153514715334166 0.199245978376662 NA NA NA 0 0 0.0925127614158782 NA NA NA NA 1426 2386 False False 0.595963883315326 0.117560076885668 1.88104014330734 0 0 0.00180134700867096 0.997545695278692 0.996632815663458 0.998262620434091 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 31 1303 8611 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.996412867391807 0.99491218317048 0.997561455575301 0.0606060606060606 0.0074258377422598 0.202264312526355 NA NA NA 0 0 0.11218874692237 NA NA NA NA 953 1774 False False 0 0 0 0 0 0 0 0.426361003144109 0.0493903613989034 1.67914733134772 0 0 0.00282706266083767 0.996412867391807 0.99491218317048 0.997561455575301 309 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1058A>G rrs_n.1058A>G 1 non_coding_transcript_exon_variant 1472903 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.1064T>C rrs_n.1064T>C 1 non_coding_transcript_exon_variant 1472909 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1067C>T rrs_n.1067C>T 1 non_coding_transcript_exon_variant 1472912 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1206 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1072G>A rrs_n.1072G>A 1 non_coding_transcript_exon_variant 1472917 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1192 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1077dupT rrs_n.1077dupT 1 non_coding_transcript_exon_variant 1472920 1 3 0 3 1 4 2048 15479 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999741652134599 0.999338660174897 0.999929604559257 0.2 0.00505076337946806 0.716417936118089 0 0 0.707598226178713 0 0 0.602364635616474 0 0 18.3057575548849 1 619.5 2386 False False 1.8895263671875 0.0383494517213545 19.1050373764475 0 0 0.00179958946453767 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 1304 8640 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999768572089794 0.999164255486522 0.999971971777513 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 257.399447522812 1 503.5 1774 False False 0 0 0 0 0 0 0 3.31288343558282 0.056110603773561 63.7302235362974 0 0 0.00282489773306727 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.1078G>A rrs_n.1078G>A 1 non_coding_transcript_exon_variant 1472923 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1364 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 895 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1089C>A rrs_n.1089C>A 1 non_coding_transcript_exon_variant 1472934 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1089C>T rrs_n.1089C>T 1 non_coding_transcript_exon_variant 1472934 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1387 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 916 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1089dupC rrs_n.1089dupC 1 non_coding_transcript_exon_variant 1472931 0 0 0 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1352 2386 False False Inf 0.193753017505121 Inf 0 0 0.00179958946453767 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 882 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0 0 0.00282489773306727 1 0.999573236258028 1 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1090G>A rrs_n.1090G>A 1 non_coding_transcript_exon_variant 1472935 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1099G>A rrs_n.1099G>A 1 non_coding_transcript_exon_variant 1472944 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1107_1118dupTGTCTCATGTTG rrs_n.1107_1118dupTGTCTCATGTTG 1 non_coding_transcript_exon_variant 1472951 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1107T>C rrs_n.1107T>C 1 non_coding_transcript_exon_variant 1472952 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1101 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 641 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 54 3) Uncertain significance No change no 1 +Capreomycin rrs n.1108_1109insA rrs_n.1108_1109insA 1 non_coding_transcript_exon_variant 1472953 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1081 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 623 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1108G>A rrs_n.1108G>A 1 non_coding_transcript_exon_variant 1472953 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1309 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 841 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 7 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1109T>A rrs_n.1109T>A 1 non_coding_transcript_exon_variant 1472954 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1182 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 716 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1109T>C rrs_n.1109T>C 1 non_coding_transcript_exon_variant 1472954 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 38 3) Uncertain significance No change no 1 +Capreomycin rrs n.1110C>T rrs_n.1110C>T 1 non_coding_transcript_exon_variant 1472955 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1207 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 739 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 55 3) Uncertain significance No change no 1 +Capreomycin rrs n.1111T>C rrs_n.1111T>C 1 non_coding_transcript_exon_variant 1472956 1 0 0 0 0 6 2049 15477 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1046 2386 False False 0 0 6.41986758323506 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 1305 8636 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 589 1774 False False 0 0 0 0 0 0 0 0 0 5.62683462374212 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 78 3) Uncertain significance No change no 1 +Capreomycin rrs n.1112_1114delCATinsTA rrs_n.1112_1114delCATinsTA 1 non_coding_transcript_exon_variant 1472957 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1068 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 610 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1112C>A rrs_n.1112C>A 1 non_coding_transcript_exon_variant 1472957 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Capreomycin rrs n.1112C>T rrs_n.1112C>T 1 non_coding_transcript_exon_variant 1472957 1 3 0 3 0 8 2049 15475 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 0 0 0.369416647552819 0 0 0.707598226178713 0 0 0.369416647552819 0 0 18.2921463704185 1 194.5 2386 False False 0 0 4.42794679154129 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 8 1305 8634 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 0 0 0.369416647552819 0 0 0.707598226178713 0 0 0.369416647552819 0 0 16.0226698715761 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 3.88085962593317 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 81 3) Uncertain significance No change no 1 +Capreomycin rrs n.1113A>G rrs_n.1113A>G 1 non_coding_transcript_exon_variant 1472958 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1047 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 590 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 9 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1113A>T rrs_n.1113A>T 1 non_coding_transcript_exon_variant 1472958 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1249 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 782 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1114T>A rrs_n.1114T>A 1 non_coding_transcript_exon_variant 1472959 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1250 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 783 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1124A>G rrs_n.1124A>G 1 non_coding_transcript_exon_variant 1472969 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1414 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 941 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 7 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1125_1132delCGTAATGGinsTTCAGT rrs_n.1125_1132delCGTAATGGinsTTCAGT 1 non_coding_transcript_exon_variant 1472970 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1130 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 670 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1125C>A rrs_n.1125C>A 1 non_coding_transcript_exon_variant 1472970 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1219 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 751 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1125C>G rrs_n.1125C>G 1 non_coding_transcript_exon_variant 1472970 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1082 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 624 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1128A>G rrs_n.1128A>G 1 non_coding_transcript_exon_variant 1472973 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1415 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 942 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 39 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1128A>T rrs_n.1128A>T 1 non_coding_transcript_exon_variant 1472973 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1083 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 625 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 88 3) Uncertain significance No change no 1 +Capreomycin rrs n.1132G>C rrs_n.1132G>C 1 non_coding_transcript_exon_variant 1472977 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1102 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 642 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1133T>C rrs_n.1133T>C 1 non_coding_transcript_exon_variant 1472978 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1251 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 784 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 9 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1137G>C rrs_n.1137G>C 1 non_coding_transcript_exon_variant 1472982 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1059 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 602 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1138A>C rrs_n.1138A>C 1 non_coding_transcript_exon_variant 1472983 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 35.2688392655279 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1141C>T rrs_n.1141C>T 1 non_coding_transcript_exon_variant 1472986 1 7 0 7 0 7 2049 15476 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 5.24430081649792 1 619.5 2386 False False 0 0 5.24430081649792 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Capreomycin rrs n.1142G>A rrs_n.1142G>A 1 non_coding_transcript_exon_variant 1472987 1 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1270 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 802 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 61 3) Uncertain significance No change no 1 +Capreomycin rrs n.1142G>T rrs_n.1142G>T 1 non_coding_transcript_exon_variant 1472987 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1346 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 876 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1143T>A rrs_n.1143T>A 1 non_coding_transcript_exon_variant 1472988 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1365 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 896 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1143T>C rrs_n.1143T>C 1 non_coding_transcript_exon_variant 1472988 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1252 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 785 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 10 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1144G>A rrs_n.1144G>A 1 non_coding_transcript_exon_variant 1472989 1 0 0 0 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1271 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 1305 8637 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 803 1774 False False 0 0 0 0 0 0 0 0 0 7.23014561016525 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 48 3) Uncertain significance No change no 1 +Capreomycin rrs n.1145A>G rrs_n.1145A>G 1 non_coding_transcript_exon_variant 1472990 NA 0 0 0 0 7 2049 15476 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1272 2386 False True 0 0 5.24430081649792 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 7 1305 8635 0 0 0.00282273611850443 0.999190002314279 0.998331811834773 0.999674278877205 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 804 1774 False True 0 1 1 0 0 0 0 0 0 4.59639609856608 0 0 0.00282273611850443 0.999190002314279 0.998331811834773 0.999674278877205 77 5) Not assoc w R UP from Uncertain to NotAwR yes 4 +Capreomycin rrs n.1147A>T rrs_n.1147A>T 1 non_coding_transcript_exon_variant 1472992 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1084 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 626 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1148_1149dupGA rrs_n.1148_1149dupGA 1 non_coding_transcript_exon_variant 1472988 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1148G>A rrs_n.1148G>A 1 non_coding_transcript_exon_variant 1472993 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 21 3) Uncertain significance No change no 1 +Capreomycin rrs n.1151T>C rrs_n.1151T>C 1 non_coding_transcript_exon_variant 1472996 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1388 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 917 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 15 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1153C>T rrs_n.1153C>T 1 non_coding_transcript_exon_variant 1472998 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance No change no 1 +Capreomycin rrs n.1157G>T rrs_n.1157G>T 1 non_coding_transcript_exon_variant 1473002 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1151 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 687 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 5 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1159T>A rrs_n.1159T>A 1 non_coding_transcript_exon_variant 1473004 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1085 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 627 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.115A>G rrs_n.115A>G 1 non_coding_transcript_exon_variant 1471960 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1377 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.1162A>C rrs_n.1162A>C 1 non_coding_transcript_exon_variant 1473007 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1353 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1163C>A rrs_n.1163C>A 1 non_coding_transcript_exon_variant 1473008 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1031 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 574 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1164T>A rrs_n.1164T>A 1 non_coding_transcript_exon_variant 1473009 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.1164T>C rrs_n.1164T>C 1 non_coding_transcript_exon_variant 1473009 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1228 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 760 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1166G>A rrs_n.1166G>A 1 non_coding_transcript_exon_variant 1473011 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1169G>C rrs_n.1169G>C 1 non_coding_transcript_exon_variant 1473014 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.116C>T rrs_n.116C>T 1 non_coding_transcript_exon_variant 1471961 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1253 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.1171A>C rrs_n.1171A>C 1 non_coding_transcript_exon_variant 1473016 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.1175dupT rrs_n.1175dupT 1 non_coding_transcript_exon_variant 1473019 1 1 0 1 1 1 2048 15482 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.99993541303365 0.999640197578315 0.999998364800924 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 293.494766828651 1 194.5 2386 False False 7.5595703125 0.096257452000026 590.418198079286 0 0 0.00179958946453767 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 1304 8641 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999884286044897 0.999355453609522 0.999997070380594 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 257.429115860043 1 503.5 1774 False False 0 0 0 0 0 0 0 6.62653374233128 0.0843535983905244 517.917818294861 0 0 0.00282489773306727 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1175T>C rrs_n.1175T>C 1 non_coding_transcript_exon_variant 1473020 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1347 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 877 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 8 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1176G>A rrs_n.1176G>A 1 non_coding_transcript_exon_variant 1473021 1 5 0 5 0 6 2049 15477 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 8.24842676385937 1 619.5 2386 False False 0 0 6.41986758323506 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Capreomycin rrs n.-117delT rrs_n.-117delT 1 upstream_gene_variant 1471728 1 2 0 2 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 40.2341634723554 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1180A>G rrs_n.1180A>G 1 non_coding_transcript_exon_variant 1473025 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1181T>C rrs_n.1181T>C 1 non_coding_transcript_exon_variant 1473026 1 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1220 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 752 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1190G>A rrs_n.1190G>A 1 non_coding_transcript_exon_variant 1473035 0 0 0 0 3 36 2046 15447 0.00146412884333821 0.000302040401839334 0.00427278776332334 0.997674869211393 0.996782477884702 0.998370991915983 0.0769230769230769 0.0161533003106583 0.208701921226443 NA NA NA 0 0 0.0973937559144919 NA NA NA NA 1086 2386 False False 0.629154447702834 0.123848524977211 1.99399419262949 0 0 0.00180134700867096 0.997674869211393 0.996782477884702 0.998370991915983 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 32 1303 8610 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.996297153436704 0.994776671397899 0.997465918686142 0.0588235294117647 0.00720491743904971 0.196773209335575 NA NA NA 0 0 0.108881160679352 NA NA NA NA 628 1774 False False 0 0 0 0 0 0 0 0.412989255564082 0.0479046623388498 1.62219200965145 0 0 0.00282706266083767 0.996297153436704 0.994776671397899 0.997465918686142 300 3) Uncertain significance No change no 1 +Capreomycin rrs n.1191T>C rrs_n.1191T>C 1 non_coding_transcript_exon_variant 1473036 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.1198G>A rrs_n.1198G>A 1 non_coding_transcript_exon_variant 1473043 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1069 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 611 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1199C>G rrs_n.1199C>G 1 non_coding_transcript_exon_variant 1473044 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1378 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 908 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 25 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.-119C>T rrs_n.-119C>T 1 upstream_gene_variant 1471727 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.11A>C rrs_n.11A>C 1 non_coding_transcript_exon_variant 1471856 0 0 0 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1310 2386 False False Inf 0.193753017505121 Inf 0 0 0.00179958946453767 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 842 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0 0 0.00282489773306727 1 0.999573236258028 1 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1208T>A rrs_n.1208T>A 1 non_coding_transcript_exon_variant 1473053 0 0 0 0 2 14 2047 15469 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.999095782471097 0.998483341560662 0.999505570487652 0.125 0.0155136038154138 0.383476236849263 NA NA NA 0 0 0.231635761650116 NA NA NA NA 1221 2386 False False 1.07955893642263 0.118984769392524 4.70616521734574 0 0 0.00180046780769359 0.999095782471097 0.998483341560662 0.999505570487652 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 12 1304 8630 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.998611432538764 0.997575709681241 0.999282307587457 0.0769230769230769 0.00194562849734675 0.360297435267877 NA NA NA 0 0 0.264648469397051 NA NA NA NA 753 1774 False False 0 0 0 0 0 0 0 0.5515081799591 0.0128948370956567 3.73372301913507 0 0 0.00282489773306727 0.998611432538764 0.997575709681241 0.999282307587457 99 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1208T>G rrs_n.1208T>G 1 non_coding_transcript_exon_variant 1473053 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 25 3) Uncertain significance No change no 1 +Capreomycin rrs n.1210C>T rrs_n.1210C>T 1 non_coding_transcript_exon_variant 1473055 1 0 0 0 0 8 2049 15475 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1366 2386 False False 0 0 4.42794679154129 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 8 1305 8634 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 897 1774 False False 0 0 0 0 0 0 0 0 0 3.88085962593317 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 119 3) Uncertain significance No change no 1 +Capreomycin rrs n.1211A>T rrs_n.1211A>T 1 non_coding_transcript_exon_variant 1473056 0 0 0 0 2 21 2047 15462 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.998643673706646 0.997927454478736 0.999160222740807 0.0869565217391304 0.0107099660378758 0.280379335909411 NA NA NA 0 0 0.161097615219079 NA NA NA NA 1152 2386 False False 0.719380277758392 0.0817149786501689 2.94658363825258 0 0 0.00180046780769359 0.998643673706646 0.997927454478736 0.999160222740807 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 19 1304 8623 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.997801434853043 0.996568788084241 0.998675817295743 0.05 0.0012650894979498 0.248732762772027 NA NA NA 0 0 0.176466911806965 NA NA NA NA 688 1774 False False 0 0 0 0 0 0 0 0.348038424281562 0.00837318474255506 2.1932385179115 0 0 0.00282489773306727 0.997801434853043 0.996568788084241 0.998675817295743 187 3) Uncertain significance No change no 1 +Capreomycin rrs n.1217T>A rrs_n.1217T>A 1 non_coding_transcript_exon_variant 1473062 0 0 0 0 3 16 2046 15467 0.00146412884333821 0.000302040401839334 0.00427278776332334 0.998966608538396 0.99832237803854 0.999409215770894 0.157894736842105 0.0338262490017646 0.395784551266674 NA NA NA 0 0 0.205907214207822 NA NA NA NA 1254 2386 False False 1.41743035190615 0.264433828913631 4.95849948719361 0 0 0.00180134700867096 0.998966608538396 0.99832237803854 0.999409215770894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 14 1303 8628 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.998380004628558 0.99728341538717 0.999114059339894 0.125 0.0155136038154138 0.383476236849263 NA NA NA 0 0 0.231635761650116 NA NA NA NA 786 1774 False False 0 0 0 0 0 0 0 0.945948909110843 0.104228363937722 4.1262852933177 0 0 0.00282706266083767 0.998380004628558 0.99728341538717 0.999114059339894 97 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1217T>G rrs_n.1217T>G 1 non_coding_transcript_exon_variant 1473062 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1229 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 761 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1220C>G rrs_n.1220C>G 1 non_coding_transcript_exon_variant 1473065 1 4 0 4 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 11.4504880046624 1 619.5 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 16.0319456706962 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.1221A>G rrs_n.1221A>G 1 non_coding_transcript_exon_variant 1473066 1 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1318 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 848 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 110 3) Uncertain significance No change no 1 +Capreomycin rrs n.1223A>G rrs_n.1223A>G 1 non_coding_transcript_exon_variant 1473068 0 0 0 0 2 18 2047 15465 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.998837434605696 0.998163265407594 0.999310849114122 0.1 0.0123485271702948 0.316982714019082 NA NA NA 0 0 0.185301968137852 NA NA NA NA 1427 2386 False False 0.839439830646474 0.0943920341800579 3.51027634190823 0 0 0.00180046780769359 0.998837434605696 0.998163265407594 0.999310849114122 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 16 1304 8626 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.998148576718352 0.996995141231936 0.998941392909931 0.0588235294117647 0.00148817439126663 0.28688939666722 NA NA NA 0 0 0.205907214207822 NA NA NA NA 954 1774 False False 0 0 0 0 0 0 0 0.413439417177914 0.00985471042276387 2.66580958878246 0 0 0.00282489773306727 0.998148576718352 0.996995141231936 0.998941392909931 86 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1225G>A rrs_n.1225G>A 1 non_coding_transcript_exon_variant 1473070 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1114 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 653 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 7 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1229C>T rrs_n.1229C>T 1 non_coding_transcript_exon_variant 1473074 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1234G>A rrs_n.1234G>A 1 non_coding_transcript_exon_variant 1473079 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Capreomycin rrs n.1235C>A rrs_n.1235C>A 1 non_coding_transcript_exon_variant 1473080 1 0 0 0 0 6 2049 15477 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1255 2386 False False 0 0 6.41986758323506 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 1305 8636 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 787 1774 False False 0 0 0 0 0 0 0 0 0 5.62683462374212 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 5 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1235C>G rrs_n.1235C>G 1 non_coding_transcript_exon_variant 1473080 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1169 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 703 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1235C>T rrs_n.1235C>T 1 non_coding_transcript_exon_variant 1473080 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1153 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 689 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 15 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1236C>T rrs_n.1236C>T 1 non_coding_transcript_exon_variant 1473081 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1115 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 654 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 56 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1237G>A rrs_n.1237G>A 1 non_coding_transcript_exon_variant 1473082 1 0 0 0 0 8 2049 15475 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1087 2386 False False 0 0 4.42794679154129 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 1305 8636 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 629 1774 False False 0 0 0 0 0 0 0 0 0 5.62683462374212 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1239T>A rrs_n.1239T>A 1 non_coding_transcript_exon_variant 1473084 1 0 0 0 0 7 2049 15476 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1379 2386 False False 0 0 5.24430081649792 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 1305 8637 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 909 1774 False False 0 0 0 0 0 0 0 0 0 7.23014561016525 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1243A>G rrs_n.1243A>G 1 non_coding_transcript_exon_variant 1473088 1 0 0 0 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1319 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 1305 8637 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 849 1774 False False 0 0 0 0 0 0 0 0 0 7.23014561016525 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 86 3) Uncertain significance No change no 1 +Capreomycin rrs n.1244A>C rrs_n.1244A>C 1 non_coding_transcript_exon_variant 1473089 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1230 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 762 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1244A>G rrs_n.1244A>G 1 non_coding_transcript_exon_variant 1473089 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.1244A>T rrs_n.1244A>T 1 non_coding_transcript_exon_variant 1473089 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1088 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 630 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1246G>A rrs_n.1246G>A 1 non_coding_transcript_exon_variant 1473091 1 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1256 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 788 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 6 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1248C>A rrs_n.1248C>A 1 non_coding_transcript_exon_variant 1473093 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1048 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 591 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1248C>G rrs_n.1248C>G 1 non_coding_transcript_exon_variant 1473093 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.1248C>T rrs_n.1248C>T 1 non_coding_transcript_exon_variant 1473093 1 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1032 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 575 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 67 3) Uncertain significance No change no 1 +Capreomycin rrs n.1249T>A rrs_n.1249T>A 1 non_coding_transcript_exon_variant 1473094 1 0 0 0 0 9 2049 15474 0 0 0.00179871197794837 0.999418717302848 0.998896832459985 0.999734167184357 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1089 2386 False False 0 0 3.82923083971975 0 0 0.00179871197794837 0.999418717302848 0.998896832459985 0.999734167184357 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 7 1305 8635 0 0 0.00282273611850443 0.999190002314279 0.998331811834773 0.999674278877205 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 631 1774 False False 0 0 0 0 0 0 0 0 0 4.59639609856608 0 0 0.00282273611850443 0.999190002314279 0.998331811834773 0.999674278877205 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.124T>C rrs_n.124T>C 1 non_coding_transcript_exon_variant 1471969 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1354 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 883 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1253A>G rrs_n.1253A>G 1 non_coding_transcript_exon_variant 1473098 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.1254T>A rrs_n.1254T>A 1 non_coding_transcript_exon_variant 1473099 1 0 0 0 0 10 2049 15473 0 0 0.00179871197794837 0.999354130336498 0.998812544515655 0.999690238326549 0 0 0.30849710781876 NA NA NA 0 0 0.30849710781876 NA NA NA NA 1060 2386 False False 0 0 3.37173073063401 0 0 0.00179871197794837 0.999354130336498 0.998812544515655 0.999690238326549 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 8 1305 8634 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 603 1774 False False 0 0 0 0 0 0 0 0 0 3.88085962593317 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 5 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1254T>G rrs_n.1254T>G 1 non_coding_transcript_exon_variant 1473099 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1193 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 725 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1255G>A rrs_n.1255G>A 1 non_coding_transcript_exon_variant 1473100 1 0 0 0 0 10 2049 15473 0 0 0.00179871197794837 0.999354130336498 0.998812544515655 0.999690238326549 0 0 0.30849710781876 NA NA NA 0 0 0.30849710781876 NA NA NA NA 1389 2386 False False 0 0 3.37173073063401 0 0 0.00179871197794837 0.999354130336498 0.998812544515655 0.999690238326549 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 10 1305 8632 0 0 0.00282273611850443 0.99884286044897 0.997873012135272 0.999444971558315 0 0 0.30849710781876 NA NA NA 0 0 0.30849710781876 NA NA NA NA 918 1774 False False 0 0 0 0 0 0 0 0 0 2.9548002607889 0 0 0.00282273611850443 0.99884286044897 0.997873012135272 0.999444971558315 26 3) Uncertain significance No change no 1 +Capreomycin rrs n.1257C>T rrs_n.1257C>T 1 non_coding_transcript_exon_variant 1473102 1 1 0 1 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 293.33332543886 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 815 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 40 3) Uncertain significance No change no 1 +Capreomycin rrs n.1259C>G rrs_n.1259C>G 1 non_coding_transcript_exon_variant 1473104 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.1259C>T rrs_n.1259C>T 1 non_coding_transcript_exon_variant 1473104 1 0 0 0 0 6 2049 15477 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1330 2386 False False 0 0 6.41986758323506 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 1305 8636 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 859 1774 False False 0 0 0 0 0 0 0 0 0 5.62683462374212 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 31 3) Uncertain significance No change no 1 +Capreomycin rrs n.125G>A rrs_n.125G>A 1 non_coding_transcript_exon_variant 1471970 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1428 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 955 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 15 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.-125G>T rrs_n.-125G>T 1 upstream_gene_variant 1471721 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.1260G>A rrs_n.1260G>A 1 non_coding_transcript_exon_variant 1473105 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1390 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 919 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1264T>C rrs_n.1264T>C 1 non_coding_transcript_exon_variant 1473109 1 1 0 1 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 293.295605628248 1 619.5 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 257.202999238191 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 2 3) Uncertain significance No change no 1 +Capreomycin rrs n.1265T>G rrs_n.1265T>G 1 non_coding_transcript_exon_variant 1473110 1 0 0 0 0 8 2049 15475 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1273 2386 False False 0 0 4.42794679154129 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 8 1305 8634 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 805 1774 False False 0 0 0 0 0 0 0 0 0 3.88085962593317 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 36 3) Uncertain significance No change no 1 +Capreomycin rrs n.1266A>G rrs_n.1266A>G 1 non_coding_transcript_exon_variant 1473111 1 0 0 0 0 8 2049 15475 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1116 2386 False False 0 0 4.42794679154129 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 8 1305 8634 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 655 1774 False False 0 0 0 0 0 0 0 0 0 3.88085962593317 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 40 3) Uncertain significance No change no 1 +Capreomycin rrs n.126A>C rrs_n.126A>C 1 non_coding_transcript_exon_variant 1471971 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.1270G>C rrs_n.1270G>C 1 non_coding_transcript_exon_variant 1473115 1 0 0 0 0 9 2049 15474 0 0 0.00179871197794837 0.999418717302848 0.998896832459985 0.999734167184357 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1297 2386 False False 0 0 3.82923083971975 0 0 0.00179871197794837 0.999418717302848 0.998896832459985 0.999734167184357 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 7 1305 8635 0 0 0.00282273611850443 0.999190002314279 0.998331811834773 0.999674278877205 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 829 1774 False False 0 0 0 0 0 0 0 0 0 4.59639609856608 0 0 0.00282273611850443 0.999190002314279 0.998331811834773 0.999674278877205 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1270G>T rrs_n.1270G>T 1 non_coding_transcript_exon_variant 1473115 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1061 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 604 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 12 3) Uncertain significance No change no 1 +Capreomycin rrs n.1275C>T rrs_n.1275C>T 1 non_coding_transcript_exon_variant 1473120 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1367 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 898 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 5 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1276T>C rrs_n.1276T>C 1 non_coding_transcript_exon_variant 1473121 NA 0 0 0 0 13 2049 15470 0 0 0.00179871197794837 0.999160369437447 0.998564634148971 0.999552858749588 0 0 0.24705263800047 NA NA NA 0 0 0.24705263800047 NA NA NA NA 1049 2386 False True 0 0 2.47945785793639 0 0 0.00179871197794837 0.999160369437447 0.998564634148971 0.999552858749588 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 12 1305 8630 0 0 0.00282273611850443 0.998611432538764 0.997575709681241 0.999282307587457 0 0 0.264648469397051 NA NA NA 0 0 0.264648469397051 NA NA NA NA 592 1774 False True 1 1 1 0 0 0 0 0 0 2.38332115036846 0 0 0.00282273611850443 0.998611432538764 0.997575709681241 0.999282307587457 89 5) Not assoc w R UP from Uncertain to NotAwR yes 4 +Capreomycin rrs n.1276T>G rrs_n.1276T>G 1 non_coding_transcript_exon_variant 1473121 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1090 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.1277T>A rrs_n.1277T>A 1 non_coding_transcript_exon_variant 1473122 NA 0 0 0 0 9 2049 15474 0 0 0.00179871197794837 0.999418717302848 0.998896832459985 0.999734167184357 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1194 2386 False True 0 0 3.82923083971975 0 0 0.00179871197794837 0.999418717302848 0.998896832459985 0.999734167184357 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 7 1305 8635 0 0 0.00282273611850443 0.999190002314279 0.998331811834773 0.999674278877205 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 726 1774 False True 1 0 1 0 0 0 0 0 0 4.59639609856608 0 0 0.00282273611850443 0.999190002314279 0.998331811834773 0.999674278877205 7 5) Not assoc w R New NotAwR yes 5 +Capreomycin rrs n.1278A>C rrs_n.1278A>C 1 non_coding_transcript_exon_variant 1473123 1 0 0 0 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1403 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 932 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1278A>G rrs_n.1278A>G 1 non_coding_transcript_exon_variant 1473123 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 3) Uncertain significance No change no 1 +Capreomycin rrs n.1278A>T rrs_n.1278A>T 1 non_coding_transcript_exon_variant 1473123 1 0 0 0 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1131 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 1305 8637 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 671 1774 False False 0 0 0 0 0 0 0 0 0 7.23014561016525 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 64 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1278delAinsTC rrs_n.1278delAinsTC 1 non_coding_transcript_exon_variant 1473123 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1298 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 830 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1279A>T rrs_n.1279A>T 1 non_coding_transcript_exon_variant 1473124 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1391 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 920 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1282G>A rrs_n.1282G>A 1 non_coding_transcript_exon_variant 1473127 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1257 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 789 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1282G>T rrs_n.1282G>T 1 non_coding_transcript_exon_variant 1473127 1 0 0 0 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1062 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 605 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1284C>T rrs_n.1284C>T 1 non_coding_transcript_exon_variant 1473129 1 0 0 0 0 7 2049 15476 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1063 2386 False False 0 0 5.24430081649792 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 1305 8636 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 606 1774 False False 0 0 0 0 0 0 0 0 0 5.62683462374212 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1285G>A rrs_n.1285G>A 1 non_coding_transcript_exon_variant 1473130 1 4 0 4 0 7 2049 15476 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 0 0 0.409616397225003 0 0 0.602364635616474 0 0 0.409616397225003 0 0 11.4482690960821 1 1029.5 2386 False False 0 0 5.24430081649792 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 5 1305 8637 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 16.028235350447 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 7.23014561016525 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 40 3) Uncertain significance No change no 1 +Capreomycin rrs n.1286G>T rrs_n.1286G>T 1 non_coding_transcript_exon_variant 1473131 1 0 0 0 0 6 2049 15477 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1241 2386 False False 0 0 6.41986758323506 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 1305 8637 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 773 1774 False False 0 0 0 0 0 0 0 0 0 7.23014561016525 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1289T>C rrs_n.1289T>C 1 non_coding_transcript_exon_variant 1473134 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.1290C>T rrs_n.1290C>T 1 non_coding_transcript_exon_variant 1473135 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1300C>T rrs_n.1300C>T 1 non_coding_transcript_exon_variant 1473145 1 0 0 0 0 12 2049 15471 0 0 0.00179871197794837 0.999224956403797 0.99864654661041 0.999599461575238 0 0 0.264648469397051 NA NA NA 0 0 0.264648469397051 NA NA NA NA 1195 2386 False False 0 0 2.71972624224414 0 0 0.00179871197794837 0.999224956403797 0.99864654661041 0.999599461575238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 12 1305 8630 0 0 0.00282273611850443 0.998611432538764 0.997575709681241 0.999282307587457 0 0 0.264648469397051 NA NA NA 0 0 0.264648469397051 NA NA NA NA 727 1774 False False 0 0 0 0 0 0 0 0 0 2.38332115036846 0 0 0.00282273611850443 0.998611432538764 0.997575709681241 0.999282307587457 143 3) Uncertain significance No change no 1 +Capreomycin rrs n.1302G>C rrs_n.1302G>C 1 non_coding_transcript_exon_variant 1473147 0 0 0 0 1 10 2048 15473 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999354130336498 0.998812544515655 0.999690238326549 0.0909090909090909 0.00229897221381426 0.412779916988382 NA NA NA 0 0 0.30849710781876 NA NA NA NA 1183 2386 False False 0.755517578125 0.0174007262411499 5.31531885538471 0 0 0.00179958946453767 0.999354130336498 0.998812544515655 0.999690238326549 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 8 1305 8634 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 717 1774 False False 0 0 0 0 0 0 0 0 0 3.88085962593317 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 6 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1302G>T rrs_n.1302G>T 1 non_coding_transcript_exon_variant 1473147 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1070 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 612 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 7 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1303G>A rrs_n.1303G>A 1 non_coding_transcript_exon_variant 1473148 0 0 0 0 1 11 2048 15472 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999289543370148 0.998729153244051 0.999645290955256 0.0833333333333333 0.00210759323186022 0.384796165150944 NA NA NA 0 0 0.284914152918154 NA NA NA NA 1154 2386 False False 0.686789772727272 0.0159480966540523 4.72976907145362 0 0 0.00179958946453767 0.999289543370148 0.998729153244051 0.999645290955256 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 9 1305 8633 0 0 0.00282273611850443 0.998958574404073 0.998023974495813 0.999523686828456 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 690 1774 False False 0 0 0 0 0 0 0 0 0 3.35590194387839 0 0 0.00282273611850443 0.998958574404073 0.998023974495813 0.999523686828456 17 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1305T>G rrs_n.1305T>G 1 non_coding_transcript_exon_variant 1473150 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1103 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 643 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.-130T>C rrs_n.-130T>C 1 upstream_gene_variant 1471716 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1316A>C rrs_n.1316A>C 1 non_coding_transcript_exon_variant 1473161 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1231 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 763 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 7 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1318C>T rrs_n.1318C>T 1 non_coding_transcript_exon_variant 1473163 1 0 0 0 0 11 2049 15472 0 0 0.00179871197794837 0.999289543370148 0.998729153244051 0.999645290955256 0 0 0.284914152918154 NA NA NA 0 0 0.284914152918154 NA NA NA NA 1104 2386 False False 0 0 3.01101772028239 0 0 0.00179871197794837 0.999289543370148 0.998729153244051 0.999645290955256 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 9 1305 8633 0 0 0.00282273611850443 0.998958574404073 0.998023974495813 0.999523686828456 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 644 1774 False False 0 0 0 0 0 0 0 0 0 3.35590194387839 0 0 0.00282273611850443 0.998958574404073 0.998023974495813 0.999523686828456 22 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1319C>A rrs_n.1319C>A 1 non_coding_transcript_exon_variant 1473164 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1429 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 956 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 9 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1319C>G rrs_n.1319C>G 1 non_coding_transcript_exon_variant 1473164 NA 0 0 0 0 10 2049 15473 0 0 0.00179871197794837 0.999354130336498 0.998812544515655 0.999690238326549 0 0 0.30849710781876 NA NA NA 0 0 0.30849710781876 NA NA NA NA 1105 2386 False True 0 0 3.37173073063401 0 0 0.00179871197794837 0.999354130336498 0.998812544515655 0.999690238326549 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 8 1305 8634 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 645 1774 False True 1 1 1 0 0 0 0 0 0 3.88085962593317 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 6 5) Not assoc w R New NotAwR yes 5 +Capreomycin rrs n.1320C>T rrs_n.1320C>T 1 non_coding_transcript_exon_variant 1473165 0 0 0 0 1 1 2048 15482 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.99993541303365 0.999640197578315 0.999998364800924 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1242 2386 False False 7.5595703125 0.096257452000026 590.418198079286 0 0 0.00179958946453767 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 774 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance No change no 1 +Capreomycin rrs n.1321G>A rrs_n.1321G>A 1 non_coding_transcript_exon_variant 1473166 1 0 0 0 0 13 2049 15470 0 0 0.00179871197794837 0.999160369437447 0.998564634148971 0.999552858749588 0 0 0.24705263800047 NA NA NA 0 0 0.24705263800047 NA NA NA NA 1430 2386 False False 0 0 2.47945785793639 0 0 0.00179871197794837 0.999160369437447 0.998564634148971 0.999552858749588 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 13 1305 8629 0 0 0.00282273611850443 0.998495718583661 0.997429006709305 0.999198798037271 0 0 0.24705263800047 NA NA NA 0 0 0.24705263800047 NA NA NA NA 957 1774 False False 0 0 0 0 0 0 0 0 0 2.17279669430301 0 0 0.00282273611850443 0.998495718583661 0.997429006709305 0.999198798037271 145 3) Uncertain significance No change no 1 +Capreomycin rrs n.1322T>G rrs_n.1322T>G 1 non_coding_transcript_exon_variant 1473167 1 2 1 1 1 1 2048 15482 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.99993541303365 0.999640197578315 0.999998364800924 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 7.5595703125 0.096257452000026 590.418198079286 0.220090832740563 119.5 2386 False False 7.5595703125 0.096257452000026 590.418198079286 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1323G>T rrs_n.1323G>T 1 non_coding_transcript_exon_variant 1473168 1 5 0 5 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 8.24895966345574 1 194.5 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance No change no 1 +Capreomycin rrs n.1325A>C rrs_n.1325A>C 1 non_coding_transcript_exon_variant 1473170 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.1327T>C rrs_n.1327T>C 1 non_coding_transcript_exon_variant 1473172 NA 0 0 0 0 9 2049 15474 0 0 0.00179871197794837 0.999418717302848 0.998896832459985 0.999734167184357 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1033 2386 False True 0 0 3.82923083971975 0 0 0.00179871197794837 0.999418717302848 0.998896832459985 0.999734167184357 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 7 1305 8635 0 0 0.00282273611850443 0.999190002314279 0.998331811834773 0.999674278877205 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 576 1774 False True 1 0 1 0 0 0 0 0 0 4.59639609856608 0 0 0.00282273611850443 0.999190002314279 0.998331811834773 0.999674278877205 18 5) Not assoc w R New NotAwR yes 5 +Capreomycin rrs n.1327T>G rrs_n.1327T>G 1 non_coding_transcript_exon_variant 1473172 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 48 3) Uncertain significance No change no 1 +Capreomycin rrs n.1328C>T rrs_n.1328C>T 1 non_coding_transcript_exon_variant 1473173 1 1 0 1 0 12 2049 15471 0 0 0.00179871197794837 0.999224956403797 0.99864654661041 0.999599461575238 0 0 0.264648469397051 0 0 0.975 0 0 0.264648469397051 0 0 293.144725939131 1 619.5 2386 False True 0 0 2.71972624224414 0 0 0.00179871197794837 0.999224956403797 0.99864654661041 0.999599461575238 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 9 1305 8633 0 0 0.00282273611850443 0.998958574404073 0.998023974495813 0.999523686828456 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 816 1774 False True 1 1 1 0 0 0 0 0 0 3.35590194387839 0 0 0.00282273611850443 0.998958574404073 0.998023974495813 0.999523686828456 61 5) Not assoc w R UP from Uncertain to NotAwR yes 4 +Capreomycin rrs n.1332G>A rrs_n.1332G>A 1 non_coding_transcript_exon_variant 1473177 NA 0 0 0 1 15 2048 15468 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999031195504747 0.998402606935329 0.999457669301639 0.0625 0.00158111172276588 0.302320738434531 NA NA NA 0 0 0.218019360910534 NA NA NA NA 1208 2386 False True 0.503515625 0.0119579364963962 3.27619715048195 0 0 0.00179958946453767 0.999031195504747 0.998402606935329 0.999457669301639 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 12 1305 8630 0 0 0.00282273611850443 0.998611432538764 0.997575709681241 0.999282307587457 0 0 0.264648469397051 NA NA NA 0 0 0.264648469397051 NA NA NA NA 740 1774 False True 0 1 1 0 0 0 0 0 0 2.38332115036846 0 0 0.00282273611850443 0.998611432538764 0.997575709681241 0.999282307587457 156 5) Not assoc w R New NotAwR yes 5 +Capreomycin rrs n.1334C>T rrs_n.1334C>T 1 non_coding_transcript_exon_variant 1473179 1 0 0 0 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1209 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 741 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 5 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.133C>T rrs_n.133C>T 1 non_coding_transcript_exon_variant 1471978 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1170 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 704 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1341A>G rrs_n.1341A>G 1 non_coding_transcript_exon_variant 1473186 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1284 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.1346C>T rrs_n.1346C>T 1 non_coding_transcript_exon_variant 1473191 1 1 0 1 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 293.295605628248 1 619.5 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 742 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 29 3) Uncertain significance No change no 1 +Capreomycin rrs n.1347A>G rrs_n.1347A>G 1 non_coding_transcript_exon_variant 1473192 0 0 0 0 1 16 2048 15467 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.998966608538396 0.99832237803854 0.999409215770894 0.0588235294117647 0.00148817439126663 0.28688939666722 NA NA NA 0 0 0.205907214207822 NA NA NA NA 1106 2386 False False 0.472015380859375 0.0112534702075532 3.04146681118005 0 0 0.00179958946453767 0.998966608538396 0.99832237803854 0.999409215770894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 12 1305 8630 0 0 0.00282273611850443 0.998611432538764 0.997575709681241 0.999282307587457 0 0 0.264648469397051 NA NA NA 0 0 0.264648469397051 NA NA NA NA 646 1774 False False 0 0 0 0 0 0 0 0 0 2.38332115036846 0 0 0.00282273611850443 0.998611432538764 0.997575709681241 0.999282307587457 163 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.134T>C rrs_n.134T>C 1 non_coding_transcript_exon_variant 1471979 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1368 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 899 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1356_1357delACinsT rrs_n.1356_1357delACinsT 1 non_coding_transcript_exon_variant 1473201 1 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1050 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 593 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 34 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1356_1360delACGCTinsTGCC rrs_n.1356_1360delACGCTinsTGCC 1 non_coding_transcript_exon_variant 1473201 0 0 0 0 1 12 2048 15471 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999224956403797 0.99864654661041 0.999599461575238 0.0769230769230769 0.00194562849734675 0.360297435267877 NA NA NA 0 0 0.264648469397051 NA NA NA NA 1258 2386 False False 0.6295166015625 0.0147222738149447 4.25890912984003 0 0 0.00179958946453767 0.999224956403797 0.99864654661041 0.999599461575238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 9 1305 8633 0 0 0.00282273611850443 0.998958574404073 0.998023974495813 0.999523686828456 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 790 1774 False False 0 0 0 0 0 0 0 0 0 3.35590194387839 0 0 0.00282273611850443 0.998958574404073 0.998023974495813 0.999523686828456 26 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1356A>T rrs_n.1356A>T 1 non_coding_transcript_exon_variant 1473201 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1117 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 656 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1356delA rrs_n.1356delA 1 non_coding_transcript_exon_variant 1473199 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1118 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 657 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 137 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1357C>T rrs_n.1357C>T 1 non_coding_transcript_exon_variant 1473202 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1311 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 843 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 7 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1359C>T rrs_n.1359C>T 1 non_coding_transcript_exon_variant 1473204 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.-135G>T rrs_n.-135G>T 1 upstream_gene_variant 1471711 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1360T>C rrs_n.1360T>C 1 non_coding_transcript_exon_variant 1473205 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1155 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 691 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 156 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1361G>A rrs_n.1361G>A 1 non_coding_transcript_exon_variant 1473206 1 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1232 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 764 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 30 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1361G>C rrs_n.1361G>C 1 non_coding_transcript_exon_variant 1473206 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.169800530161289 Inf 0.131195335276967 59 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1367A>G rrs_n.1367A>G 1 non_coding_transcript_exon_variant 1473212 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.136C>T rrs_n.136C>T 1 non_coding_transcript_exon_variant 1471981 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1379G>A rrs_n.1379G>A 1 non_coding_transcript_exon_variant 1473224 1 7 0 7 0 7 2049 15476 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 5.24430081649792 1 619.5 2386 False False 0 0 5.24430081649792 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 1305 8636 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 5.62683462374212 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 5.62683462374212 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 6 3) Uncertain significance No change no 1 +Capreomycin rrs n.1381C>T rrs_n.1381C>T 1 non_coding_transcript_exon_variant 1473226 1 0 0 0 0 8 2049 15475 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1331 2386 False False 0 0 4.42794679154129 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 1305 8637 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 860 1774 False False 0 0 0 0 0 0 0 0 0 7.23014561016525 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 46 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1382C>G rrs_n.1382C>G 1 non_coding_transcript_exon_variant 1473227 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.138C>T rrs_n.138C>T 1 non_coding_transcript_exon_variant 1471983 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1431 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 958 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1401A>G rrs_n.1401A>G 1 non_coding_transcript_exon_variant 1473246 1 1398 1130 268 1190 286 859 15197 0.580771107857491 0.559059021339353 0.602251734239434 0.981528127623845 0.979282125947745 0.983590512077673 0.806233062330623 0.78512910564208 0.826110705972686 0.80829756795422 0.786666006808792 0.828624854498209 0.798022598870056 0.776149730159269 0.818651379119776 74.5947648254652 63.9422095213272 87.0759862422648 0 1 2386 True False 73.6114932797121 63.5758662622257 85.596880546511 0.568124685771744 0.546017546130325 0.590030687711387 0.981528127623845 0.979282125947745 0.983590512077673 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 864 729 135 774 148 531 8494 0.593103448275862 0.565881976571308 0.619904588426919 0.982874334644758 0.97991250743149 0.985503811433509 0.839479392624728 0.814164958376642 0.862602040882787 0.84375 0.817794576463629 0.867334321672736 0.831242873432155 0.804782158688771 0.855455107104963 86.3796610169491 70.261765647715 106.466744842514 0 1 1774 True False 0 0 0 0 0 0 0 83.6559780119102 68.4017261386419 102.43305212444 0.578571428571428 0.550752740240986 0.606022654022906 0.982874334644758 0.97991250743149 0.985503811433509 1248 Assoc w R Assoc w R Marker of R 1) Assoc w R No change yes 1 +Capreomycin rrs n.1402C>A rrs_n.1402C>A 1 non_coding_transcript_exon_variant 1473247 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1034 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 577 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 21 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1402C>T rrs_n.1402C>T 1 non_coding_transcript_exon_variant 1473247 1 18 15 3 17 3 2032 15480 0.00829673011224987 0.00484036444543717 0.013250735092242 0.999806239100949 0.999433853882399 0.999960040061829 0.85 0.621073173454686 0.967929062814536 0.833333333333333 0.585822508605226 0.964214916878425 0.833333333333333 0.585822508605226 0.964214916878425 38.0905511811023 10.7590409243103 205.194273395127 5.6499885785121e-12 6 2386 True False 43.1692913385826 12.4649709524758 229.601077963469 0.00732779677576941 0.00410694278047841 0.0120573283070279 0.999806239100949 0.999433853882399 0.999960040061829 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 15 13 2 14 2 1291 8640 0.010727969348659 0.00587714446889993 0.0179342601005183 0.999768572089794 0.999164255486522 0.999971971777513 0.875 0.616523763150736 0.984486396184586 0.866666666666666 0.595397303396627 0.983424086559916 0.866666666666666 0.595397303396627 0.983424086559916 43.5011618900077 9.82655226610353 396.979133942039 2.60637842704742e-10 4 1774 True False 0 0 0 0 0 0 0 46.847405112316 10.7344451712079 424.564067495102 0.00996932515337423 0.00531862201114252 0.0169875153506984 0.999768572089794 0.999164255486522 0.999971971777513 16 Assoc w R Assoc w R Marker of R 1) Assoc w R No change yes 1 +Capreomycin rrs n.1403G>A rrs_n.1403G>A 1 non_coding_transcript_exon_variant 1473248 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1332 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 861 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 8 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1404T>C rrs_n.1404T>C 1 non_coding_transcript_exon_variant 1473249 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1274 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 806 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 8 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1407T>C rrs_n.1407T>C 1 non_coding_transcript_exon_variant 1473252 NA 0 0 0 0 8 2049 15475 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1369 2386 False True 0 0 4.42794679154129 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 7 1305 8635 0 0 0.00282273611850443 0.999190002314279 0.998331811834773 0.999674278877205 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 900 1774 False True 0 1 1 0 0 0 0 0 0 4.59639609856608 0 0 0.00282273611850443 0.999190002314279 0.998331811834773 0.999674278877205 76 5) Not assoc w R New NotAwR yes 5 +Capreomycin rrs n.1409A>G rrs_n.1409A>G 1 non_coding_transcript_exon_variant 1473254 1 3 0 3 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 18.2980327465689 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.140T>C rrs_n.140T>C 1 non_coding_transcript_exon_variant 1471985 1 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1275 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 807 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 5 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.140T>G rrs_n.140T>G 1 non_coding_transcript_exon_variant 1471985 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 35.2688392655279 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.1410A>G rrs_n.1410A>G 1 non_coding_transcript_exon_variant 1473255 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1348 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 878 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1413T>C rrs_n.1413T>C 1 non_coding_transcript_exon_variant 1473258 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1171 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 705 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1414C>T rrs_n.1414C>T 1 non_coding_transcript_exon_variant 1473259 1 1 0 1 0 6 2049 15477 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 0 0 0.4592581264399 0 0 0.975 0 0 0.4592581264399 0 0 293.257885772969 1 619.5 2386 False False 0 0 6.41986758323506 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 775 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 84 3) Uncertain significance No change no 1 +Capreomycin rrs n.1415G>T rrs_n.1415G>T 1 non_coding_transcript_exon_variant 1473260 1 1 0 1 1 2 2048 15481 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999870826067299 0.999533458063883 0.999984356054634 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 293.475897815623 1 619.5 2386 False False 3.779541015625 0.0640320806562028 72.4657839845296 0 0 0.00179958946453767 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 1304 8641 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999884286044897 0.999355453609522 0.999997070380594 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 257.429115860043 1 503.5 1774 False False 0 0 0 0 0 0 0 6.62653374233128 0.0843535983905244 517.917818294861 0 0 0.00282489773306727 0.999884286044897 0.999355453609522 0.999997070380594 4 3) Uncertain significance No change no 1 +Capreomycin rrs n.1416G>A rrs_n.1416G>A 1 non_coding_transcript_exon_variant 1473261 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.-141A>G rrs_n.-141A>G 1 upstream_gene_variant 1471705 1 5 1 4 1 4 2048 15479 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999741652134599 0.999338660174897 0.999929604559257 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 1.8895263671875 0.0383494517213545 19.1050373764475 0.462862503415467 151 2386 False False 1.8895263671875 0.0383494517213545 19.1050373764475 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Capreomycin rrs n.141C>T rrs_n.141C>T 1 non_coding_transcript_exon_variant 1471986 1 2 0 2 0 7 2049 15476 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 0 0 0.409616397225003 0 0 0.841886116991581 0 0 0.409616397225003 0 0 40.2237806927257 1 619.5 2386 False False 0 0 5.24430081649792 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 6 1305 8636 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 0 0 0.4592581264399 0 0 0.975 0 0 0.4592581264399 0 0 257.084415819978 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 5.62683462374212 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 10 3) Uncertain significance No change no 1 +Capreomycin rrs n.-142C>T rrs_n.-142C>T 1 upstream_gene_variant 1471704 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.142G>A rrs_n.142G>A 1 non_coding_transcript_exon_variant 1471987 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 12 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1431A>G rrs_n.1431A>G 1 non_coding_transcript_exon_variant 1473276 1 0 0 0 0 6 2049 15477 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1392 2386 False False 0 0 6.41986758323506 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 1305 8637 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 921 1774 False False 0 0 0 0 0 0 0 0 0 7.23014561016525 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 29 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1432G>A rrs_n.1432G>A 1 non_coding_transcript_exon_variant 1473277 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 35 3) Uncertain significance No change no 1 +Capreomycin rrs n.1436C>A rrs_n.1436C>A 1 non_coding_transcript_exon_variant 1473281 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1071 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1437C>G rrs_n.1437C>G 1 non_coding_transcript_exon_variant 1473282 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1141 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1438T>C rrs_n.1438T>C 1 non_coding_transcript_exon_variant 1473283 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1051 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 594 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1443_1446delCTCGinsTTTTA rrs_n.1443_1446delCTCGinsTTTTA 1 non_coding_transcript_exon_variant 1473288 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1312 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1443C>G rrs_n.1443C>G 1 non_coding_transcript_exon_variant 1473288 1 29 2 27 2 30 2047 15453 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.998062391009494 0.99723508866369 0.998692333308913 0.0625 0.00766073634645639 0.208069429895007 0.0689655172413793 0.00846396225300182 0.227661889944486 0.0625 0.00766073634645639 0.208069429895007 0.559192313955381 0.0643942204115085 2.22808287658253 0.571039997757046 158 2386 False False 0.503273082559843 0.0582413977858185 1.98592876745223 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.998062391009494 0.99723508866369 0.998692333308913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 28 2 26 2 29 1303 8613 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.996644295302013 0.995184176294224 0.997751515158685 0.064516129032258 0.0079109834618547 0.214216157163402 0.0714285714285714 0.00877049670352713 0.23503477317459 0.064516129032258 0.0079109834618547 0.214216157163402 0.508471574473109 0.0584264679640072 2.0351150788429 0.572137034547491 108 1774 False False 0 0 0 0 0 0 0 0.455871066768994 0.0526551893264078 1.80577032287561 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.996644295302013 0.995184176294224 0.997751515158685 58 3) Uncertain significance No change no 1 +Capreomycin rrs n.1443C>T rrs_n.1443C>T 1 non_coding_transcript_exon_variant 1473288 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1393 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 922 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1444_1445delTCinsCTCGT rrs_n.1444_1445delTCinsCTCGT 1 non_coding_transcript_exon_variant 1473289 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1184 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 718 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1444_1445delTCinsCTTGT rrs_n.1444_1445delTCinsCTTGT 1 non_coding_transcript_exon_variant 1473289 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1394 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 923 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1445_1446delCGinsTGT rrs_n.1445_1446delCGinsTGT 1 non_coding_transcript_exon_variant 1473290 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1285 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 817 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1445C>A rrs_n.1445C>A 1 non_coding_transcript_exon_variant 1473290 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1445C>T rrs_n.1445C>T 1 non_coding_transcript_exon_variant 1473290 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1196 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 728 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 9 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1446G>T rrs_n.1446G>T 1 non_coding_transcript_exon_variant 1473291 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1156 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 692 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1449A>G rrs_n.1449A>G 1 non_coding_transcript_exon_variant 1473294 1 5 0 5 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 8.24895966345574 1 194.5 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 3) Uncertain significance No change no 1 +Capreomycin rrs n.1451G>C rrs_n.1451G>C 1 non_coding_transcript_exon_variant 1473296 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1333 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1452G>T rrs_n.1452G>T 1 non_coding_transcript_exon_variant 1473297 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1276 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1456T>C rrs_n.1456T>C 1 non_coding_transcript_exon_variant 1473301 1 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1222 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 754 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 22 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1460G>A rrs_n.1460G>A 1 non_coding_transcript_exon_variant 1473305 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 4 3) Uncertain significance No change no 1 +Capreomycin rrs n.1465T>G rrs_n.1465T>G 1 non_coding_transcript_exon_variant 1473310 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Capreomycin rrs n.1470T>C rrs_n.1470T>C 1 non_coding_transcript_exon_variant 1473315 1 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1416 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 943 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 13 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1471C>A rrs_n.1471C>A 1 non_coding_transcript_exon_variant 1473316 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1404 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1471C>T rrs_n.1471C>T 1 non_coding_transcript_exon_variant 1473316 1 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1395 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 924 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 60 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1472G>A rrs_n.1472G>A 1 non_coding_transcript_exon_variant 1473317 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1380 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1473G>A rrs_n.1473G>A 1 non_coding_transcript_exon_variant 1473318 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1052 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1474C>T rrs_n.1474C>T 1 non_coding_transcript_exon_variant 1473319 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1185 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1479G>A rrs_n.1479G>A 1 non_coding_transcript_exon_variant 1473324 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1381 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 3) Uncertain significance No change no 1 +Capreomycin rrs n.-147G>T rrs_n.-147G>T 1 upstream_gene_variant 1471699 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1482A>G rrs_n.1482A>G 1 non_coding_transcript_exon_variant 1473327 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1405 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1483C>T rrs_n.1483C>T 1 non_coding_transcript_exon_variant 1473328 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1157 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1484G>A rrs_n.1484G>A 1 non_coding_transcript_exon_variant 1473329 1 2 1 1 1 1 2048 15482 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.99993541303365 0.999640197578315 0.999998364800924 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 7.5595703125 0.096257452000026 590.418198079286 0.220090832740563 119.5 2386 False False 7.5595703125 0.096257452000026 590.418198079286 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.1484G>T rrs_n.1484G>T 1 non_coding_transcript_exon_variant 1473329 1 18 15 3 18 3 2031 15480 0.00878477306002928 0.00521448485187275 0.0138483197459783 0.999806239100949 0.999433853882399 0.999960040061829 0.857142857142857 0.636576012983019 0.969511032378484 0.833333333333333 0.585822508605226 0.964214916878425 0.833333333333333 0.585822508605226 0.964214916878425 38.109305760709 10.7643124096456 205.29471984459 5.61428307838007e-12 5 2386 True False 45.7311669128508 13.3326117663309 241.842156442775 0.00733137829912023 0.00410895284503771 0.0120632073649538 0.999806239100949 0.999433853882399 0.999960040061829 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 11 9 2 11 2 1294 8640 0.00842911877394636 0.00421507924028861 0.0150318657066704 0.999768572089794 0.999164255486522 0.999971971777513 0.846153846153846 0.545528944323442 0.980793328017471 0.818181818181818 0.482244147639827 0.97716880170004 0.818181818181818 0.482244147639827 0.97716880170004 30.0463678516228 6.20517106476011 283.831484757467 4.76160747569024e-07 5 1774 True False 0 0 0 0 0 0 0 36.7233384853168 7.99448122729649 340.985099966463 0.00690713737528779 0.00316310426537447 0.0130712397611215 0.999768572089794 0.999164255486522 0.999971971777513 28 Assoc w R Assoc w R Marker of R 1) Assoc w R No change yes 1 +Capreomycin rrs n.1489C>T rrs_n.1489C>T 1 non_coding_transcript_exon_variant 1473334 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Capreomycin rrs n.1491T>A rrs_n.1491T>A 1 non_coding_transcript_exon_variant 1473336 1 5 0 5 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 8.24895966345574 1 194.5 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 1305 8637 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 7.23014561016525 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 7.23014561016525 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 2 3) Uncertain significance No change no 1 +Capreomycin rrs n.1500A>T rrs_n.1500A>T 1 non_coding_transcript_exon_variant 1473345 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.1503C>T rrs_n.1503C>T 1 non_coding_transcript_exon_variant 1473348 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.1507C>T rrs_n.1507C>T 1 non_coding_transcript_exon_variant 1473352 0 0 0 0 2 14 2047 15469 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.999095782471097 0.998483341560662 0.999505570487652 0.125 0.0155136038154138 0.383476236849263 NA NA NA 0 0 0.231635761650116 NA NA NA NA 1035 2386 False False 1.07955893642263 0.118984769392524 4.70616521734574 0 0 0.00180046780769359 0.999095782471097 0.998483341560662 0.999505570487652 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 10 1304 8632 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.99884286044897 0.997873012135272 0.999444971558315 0.0909090909090909 0.00229897221381426 0.412779916988382 NA NA NA 0 0 0.30849710781876 NA NA NA NA 578 1774 False False 0 0 0 0 0 0 0 0.661963190184049 0.0152450183707615 4.66012809367242 0 0 0.00282489773306727 0.99884286044897 0.997873012135272 0.999444971558315 131 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1515T>C rrs_n.1515T>C 1 non_coding_transcript_exon_variant 1473360 0 0 0 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1119 2386 False False Inf 0.193753017505121 Inf 0 0 0.00179958946453767 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 658 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0 0 0.00282489773306727 1 0.999573236258028 1 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.1523G>A rrs_n.1523G>A 1 non_coding_transcript_exon_variant 1473368 1 4 1 3 1 3 2048 15480 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999806239100949 0.999433853882399 0.999960040061829 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 2.51953125 0.047970285762596 31.379124977949 0.391760059426727 144.5 2386 False False 2.51953125 0.047970285762596 31.379124977949 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.160dupT rrs_n.160dupT 1 non_coding_transcript_exon_variant 1472004 1 3 2 1 2 1 2047 15482 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.99993541303365 0.999640197578315 0.999998364800924 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 15.1265266243282 0.786906901669143 886.86117101553 0.0377709372796861 30 2386 False False 15.1265266243282 0.786906901669143 886.86117101553 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 1303 8642 0.00153256704980842 0.000185654897205815 0.00552508794778556 1 0.999573236258028 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 1.24419098853007 Inf 0.0172007558014444 21.5 1774 False False 0 0 0 0 0 0 0 Inf 1.24419098853007 Inf 0.00153256704980842 0.000185654897205815 0.00552508794778556 1 0.999573236258028 1 2 3) Uncertain significance No change no 1 +Capreomycin rrs n.165C>A rrs_n.165C>A 1 non_coding_transcript_exon_variant 1472010 1 1 0 1 1 1 2048 15482 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.99993541303365 0.999640197578315 0.999998364800924 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 293.494766828651 1 194.5 2386 False False 7.5595703125 0.096257452000026 590.418198079286 0 0 0.00179958946453767 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 1304 8641 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999884286044897 0.999355453609522 0.999997070380594 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 257.429115860043 1 503.5 1774 False False 0 0 0 0 0 0 0 6.62653374233128 0.0843535983905244 517.917818294861 0 0 0.00282489773306727 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.169T>C rrs_n.169T>C 1 non_coding_transcript_exon_variant 1472014 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.16T>A rrs_n.16T>A 1 non_coding_transcript_exon_variant 1471861 1 2 0 2 1 2 2048 15481 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999870826067299 0.999533458063883 0.999984356054634 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2563859690691 1 619.5 2386 False False 3.779541015625 0.0640320806562028 72.4657839845296 0 0 0.00179958946453767 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.16T>C rrs_n.16T>C 1 non_coding_transcript_exon_variant 1471861 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 4 3) Uncertain significance No change no 1 +Capreomycin rrs n.16T>G rrs_n.16T>G 1 non_coding_transcript_exon_variant 1471861 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.178G>A rrs_n.178G>A 1 non_coding_transcript_exon_variant 1472023 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.169800530161289 Inf 0.131195335276967 59 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.179G>T rrs_n.179G>T 1 non_coding_transcript_exon_variant 1472024 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.17T>G rrs_n.17T>G 1 non_coding_transcript_exon_variant 1471862 1 7 0 7 1 8 2048 15475 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999483304269198 0.998982158652985 0.999776901906193 0.111111111111111 0.00280913674659921 0.482496514917337 0 0 0.409616397225003 0 0 0.369416647552819 0 0 5.24652426030038 1 619.5 2386 False False 0.94451904296875 0.021275762868979 7.05211630192235 0 0 0.00179958946453767 0.999483304269198 0.998982158652985 0.999776901906193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 1 6 1304 8636 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999305716269382 0.998489453757575 0.999745168847445 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.521823750104981 0 0 0.4592581264399 0 0 7.23485739043272 1 503.5 1774 False False 0 0 0 0 0 0 0 1.10378323108384 0.0239783465953148 9.10896322125085 0 0 0.00282489773306727 0.999305716269382 0.998489453757575 0.999745168847445 12 3) Uncertain significance No change no 1 +Capreomycin rrs n.180A>C rrs_n.180A>C 1 non_coding_transcript_exon_variant 1472025 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.181C>T rrs_n.181C>T 1 non_coding_transcript_exon_variant 1472026 0 0 0 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1406 2386 False False Inf 0.193753017505121 Inf 0 0 0.00179958946453767 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 933 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0 0 0.00282489773306727 1 0.999573236258028 1 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.182_200dupCACGGGATGCATGTCTTGT rrs_n.182_200dupCACGGGATGCATGTCTTGT 1 non_coding_transcript_exon_variant 1472026 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1432 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.182C>G rrs_n.182C>G 1 non_coding_transcript_exon_variant 1472027 1 2 0 2 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 40.2341634723554 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.184C>T rrs_n.184C>T 1 non_coding_transcript_exon_variant 1472029 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1197 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 729 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.185G>A rrs_n.185G>A 1 non_coding_transcript_exon_variant 1472030 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1072 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 613 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.186G>C rrs_n.186G>C 1 non_coding_transcript_exon_variant 1472031 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1259 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 791 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.187G>A rrs_n.187G>A 1 non_coding_transcript_exon_variant 1472032 1 2 0 2 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 40.2341634723554 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 35.2647591017504 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.188A>C rrs_n.188A>C 1 non_coding_transcript_exon_variant 1472033 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1036 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 579 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.190G>T rrs_n.190G>T 1 non_coding_transcript_exon_variant 1472035 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1210 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 743 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.195T>G rrs_n.195T>G 1 non_coding_transcript_exon_variant 1472040 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1299 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 831 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.196C>T rrs_n.196C>T 1 non_coding_transcript_exon_variant 1472041 1 2 0 2 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 0 0 0.841886116991581 0 0 0.521823750104981 0 0 40.2289720864225 1 619.5 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 257.143707584236 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 1 3) Uncertain significance No change no 1 +Capreomycin rrs n.197T>C rrs_n.197T>C 1 non_coding_transcript_exon_variant 1472042 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1396 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 925 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.197T>G rrs_n.197T>G 1 non_coding_transcript_exon_variant 1472042 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1417 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 944 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.198T>A rrs_n.198T>A 1 non_coding_transcript_exon_variant 1472043 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1142 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 679 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.-2_-1insGTTTTGTTTGGAGA rrs_n.-2_-1insGTTTTGTTTGGAGA 1 upstream_gene_variant 1471844 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1045 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Capreomycin rrs n.200T>A rrs_n.200T>A 1 non_coding_transcript_exon_variant 1472045 1 4 0 4 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 11.4497483684733 1 619.5 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 5 1305 8637 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 10.0352432576349 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 7.23014561016525 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 9 3) Uncertain significance No change no 1 +Capreomycin rrs n.203T>C rrs_n.203T>C 1 non_coding_transcript_exon_variant 1472048 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.204G>A rrs_n.204G>A 1 non_coding_transcript_exon_variant 1472049 1 6 0 6 0 6 2049 15477 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 6.41986758323506 1 619.5 2386 False False 0 0 6.41986758323506 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 1305 8636 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 5.62683462374212 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 5.62683462374212 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 1 3) Uncertain significance No change no 1 +Capreomycin rrs n.205G>C rrs_n.205G>C 1 non_coding_transcript_exon_variant 1472050 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1091 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 632 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.211_212delGC rrs_n.211_212delGC 1 non_coding_transcript_exon_variant 1472053 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1064 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 607 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.212C>T rrs_n.212C>T 1 non_coding_transcript_exon_variant 1472057 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Capreomycin rrs n.213T>A rrs_n.213T>A 1 non_coding_transcript_exon_variant 1472058 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.213T>C rrs_n.213T>C 1 non_coding_transcript_exon_variant 1472058 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.213T>G rrs_n.213T>G 1 non_coding_transcript_exon_variant 1472058 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Capreomycin rrs n.216A>T rrs_n.216A>T 1 non_coding_transcript_exon_variant 1472061 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1233 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 765 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.225G>C rrs_n.225G>C 1 non_coding_transcript_exon_variant 1472070 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.230A>G rrs_n.230A>G 1 non_coding_transcript_exon_variant 1472075 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1037 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 580 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.236C>G rrs_n.236C>G 1 non_coding_transcript_exon_variant 1472081 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.239C>A rrs_n.239C>A 1 non_coding_transcript_exon_variant 1472084 1 2 1 1 1 1 2048 15482 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.99993541303365 0.999640197578315 0.999998364800924 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 7.5595703125 0.096257452000026 590.418198079286 0.220090832740563 119.5 2386 False False 7.5595703125 0.096257452000026 590.418198079286 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.23T>C rrs_n.23T>C 1 non_coding_transcript_exon_variant 1471868 1 1 0 1 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 293.314465539138 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 862 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance No change no 1 +Capreomycin rrs n.23T>G rrs_n.23T>G 1 non_coding_transcript_exon_variant 1471868 1 3 0 3 1 3 2048 15480 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999806239100949 0.999433853882399 0.999960040061829 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 18.30693542144 1 619.5 2386 False False 2.51953125 0.047970285762596 31.379124977949 0 0 0.00179958946453767 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 1304 8640 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999768572089794 0.999164255486522 0.999971971777513 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 35.2958866065447 1 503.5 1774 False False 0 0 0 0 0 0 0 3.31288343558282 0.056110603773561 63.7302235362974 0 0 0.00282489773306727 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.247C>T rrs_n.247C>T 1 non_coding_transcript_exon_variant 1472092 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Capreomycin rrs n.24G>A rrs_n.24G>A 1 non_coding_transcript_exon_variant 1471869 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1320 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 850 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.257G>A rrs_n.257G>A 1 non_coding_transcript_exon_variant 1472102 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1120 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 659 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 9 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.259dupG rrs_n.259dupG 1 non_coding_transcript_exon_variant 1472100 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1433 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Capreomycin rrs n.-25C>A rrs_n.-25C>A 1 upstream_gene_variant 1471821 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.261G>A rrs_n.261G>A 1 non_coding_transcript_exon_variant 1472106 1 0 0 0 0 7 2049 15476 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1092 2386 False False 0 0 5.24430081649792 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 7 1305 8635 0 0 0.00282273611850443 0.999190002314279 0.998331811834773 0.999674278877205 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 633 1774 False False 0 0 0 0 0 0 0 0 0 4.59639609856608 0 0 0.00282273611850443 0.999190002314279 0.998331811834773 0.999674278877205 71 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.262A>G rrs_n.262A>G 1 non_coding_transcript_exon_variant 1472107 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1073 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 614 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 6 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.263C>T rrs_n.263C>T 1 non_coding_transcript_exon_variant 1472108 1 0 0 0 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1107 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 1305 8637 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 647 1774 False False 0 0 0 0 0 0 0 0 0 7.23014561016525 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 71 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.266C>T rrs_n.266C>T 1 non_coding_transcript_exon_variant 1472111 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance No change no 1 +Capreomycin rrs n.267C>T rrs_n.267C>T 1 non_coding_transcript_exon_variant 1472112 1 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1418 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 945 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 31 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.268T>C rrs_n.268T>C 1 non_coding_transcript_exon_variant 1472113 1 3 0 3 0 9 2049 15474 0 0 0.00179871197794837 0.999418717302848 0.998896832459985 0.999734167184357 0 0 0.336267116879942 0 0 0.707598226178713 0 0 0.336267116879942 0 0 18.2909691003004 1 194.5 2386 False False 0 0 3.82923083971975 0 0 0.00179871197794837 0.999418717302848 0.998896832459985 0.999734167184357 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 9 1305 8633 0 0 0.00282273611850443 0.998958574404073 0.998023974495813 0.999523686828456 0 0 0.336267116879942 0 0 0.707598226178713 0 0 0.336267116879942 0 0 16.0208147123538 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 3.35590194387839 0 0 0.00282273611850443 0.998958574404073 0.998023974495813 0.999523686828456 15 3) Uncertain significance No change no 1 +Capreomycin rrs n.273A>T rrs_n.273A>T 1 non_coding_transcript_exon_variant 1472118 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.277G>A rrs_n.277G>A 1 non_coding_transcript_exon_variant 1472122 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1038 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 581 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 15 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.278A>G rrs_n.278A>G 1 non_coding_transcript_exon_variant 1472123 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1172 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 706 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.279C>A rrs_n.279C>A 1 non_coding_transcript_exon_variant 1472124 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.279C>T rrs_n.279C>T 1 non_coding_transcript_exon_variant 1472124 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1173 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 707 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 37 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.282C>T rrs_n.282C>T 1 non_coding_transcript_exon_variant 1472127 0 0 0 0 1 9 2048 15474 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999418717302848 0.998896832459985 0.999734167184357 0.1 0.00252857854446178 0.445016117028195 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1108 2386 False False 0.839518229166666 0.0191442481599193 6.06407759157277 0 0 0.00179958946453767 0.999418717302848 0.998896832459985 0.999734167184357 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 8 1304 8634 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999074288359176 0.998176798225858 0.999600261389848 0.111111111111111 0.00280913674659921 0.482496514917337 NA NA NA 0 0 0.369416647552819 NA NA NA NA 648 1774 False False 0 0 0 0 0 0 0 0.827645705521472 0.0186379987589414 6.18187193560828 0 0 0.00282489773306727 0.999074288359176 0.998176798225858 0.999600261389848 55 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.284G>C rrs_n.284G>C 1 non_coding_transcript_exon_variant 1472129 0 0 0 0 1 9 2048 15474 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999418717302848 0.998896832459985 0.999734167184357 0.1 0.00252857854446178 0.445016117028195 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1234 2386 False False 0.839518229166666 0.0191442481599193 6.06407759157277 0 0 0.00179958946453767 0.999418717302848 0.998896832459985 0.999734167184357 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 8 1304 8634 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999074288359176 0.998176798225858 0.999600261389848 0.111111111111111 0.00280913674659921 0.482496514917337 NA NA NA 0 0 0.369416647552819 NA NA NA NA 766 1774 False False 0 0 0 0 0 0 0 0.827645705521472 0.0186379987589414 6.18187193560828 0 0 0.00282489773306727 0.999074288359176 0.998176798225858 0.999600261389848 50 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.287A>G rrs_n.287A>G 1 non_coding_transcript_exon_variant 1472132 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.-28G>A rrs_n.-28G>A 1 upstream_gene_variant 1471818 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.292G>A rrs_n.292G>A 1 non_coding_transcript_exon_variant 1472137 0 0 0 0 3 11 2046 15472 0.00146412884333821 0.000302040401839334 0.00427278776332334 0.999289543370148 0.998729153244051 0.999645290955256 0.214285714285714 0.0465792878898673 0.507975677048471 NA NA NA 0 0 0.284914152918154 NA NA NA NA 1355 2386 False False 2.06238336443615 0.369123151192947 7.81548741330829 0 0 0.00180134700867096 0.999289543370148 0.998729153244051 0.999645290955256 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 10 1303 8632 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.99884286044897 0.997873012135272 0.999444971558315 0.166666666666666 0.0208625254600923 0.484137748685967 NA NA NA 0 0 0.30849710781876 NA NA NA NA 884 1774 False False 0 0 0 0 0 0 0 1.32494244052187 0.141022691102851 6.22733061547632 0 0 0.00282706266083767 0.99884286044897 0.997873012135272 0.999444971558315 101 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.298_299insT rrs_n.298_299insT 1 non_coding_transcript_exon_variant 1472143 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 35.2688392655279 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.299A>G rrs_n.299A>G 1 non_coding_transcript_exon_variant 1472144 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.300_301insT rrs_n.300_301insT 1 non_coding_transcript_exon_variant 1472145 0 0 0 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1074 2386 False False Inf 0.193753017505121 Inf 0 0 0.00179958946453767 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 615 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0 0 0.00282489773306727 1 0.999573236258028 1 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.303T>C rrs_n.303T>C 1 non_coding_transcript_exon_variant 1472148 1 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1243 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 776 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 8 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.304_305dupGT rrs_n.304_305dupGT 1 non_coding_transcript_exon_variant 1472146 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1300 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 832 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.305T>A rrs_n.305T>A 1 non_coding_transcript_exon_variant 1472150 NA 0 0 0 3 21 2046 15462 0.00146412884333821 0.000302040401839334 0.00427278776332334 0.998643673706646 0.997927454478736 0.999160222740807 0.125 0.0265593149862489 0.323611358188833 NA NA NA 0 0 0.161097615219079 NA NA NA NA 1397 2386 False True 1.0795978215333 0.206008566183672 3.62021227041467 0 0 0.00180134700867096 0.998643673706646 0.997927454478736 0.999160222740807 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 2 20 1303 8622 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.99768572089794 0.996428035548426 0.998585822914007 0.0909090909090909 0.0112055860241509 0.291612741553933 NA NA NA 0 0 0.168433470983085 NA NA NA NA 926 1774 False True 0 1 1 0 0 0 0 0.661703760552571 0.0749039402438469 2.72915498621417 0 0 0.00282706266083767 0.99768572089794 0.996428035548426 0.998585822914007 226 5) Not assoc w R UP from Uncertain to NotAwR yes 4 +Capreomycin rrs n.306C>A rrs_n.306C>A 1 non_coding_transcript_exon_variant 1472151 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1286 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 818 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 15 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.306C>T rrs_n.306C>T 1 non_coding_transcript_exon_variant 1472151 1 1 0 1 3 11 2046 15472 0.00146412884333821 0.000302040401839334 0.00427278776332334 0.999289543370148 0.998729153244051 0.999645290955256 0.214285714285714 0.0465792878898673 0.507975677048471 0 0 0.975 0 0 0.284914152918154 0 0 293.591472650571 1 619.5 2386 False False 2.06238336443615 0.369123151192947 7.81548741330829 0 0 0.00180134700867096 0.999289543370148 0.998729153244051 0.999645290955256 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 9 1303 8633 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.998958574404073 0.998023974495813 0.999523686828456 0.181818181818181 0.0228311982999596 0.517755852360172 NA NA NA 0 0 0.336267116879942 NA NA NA NA 863 1774 False False 0 0 0 0 0 0 0 1.47232881384838 0.154604541408076 7.12417170347034 0 0 0.00282706266083767 0.998958574404073 0.998023974495813 0.999523686828456 92 3) Uncertain significance No change no 1 +Capreomycin rrs n.307C>T rrs_n.307C>T 1 non_coding_transcript_exon_variant 1472152 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.315C>T rrs_n.315C>T 1 non_coding_transcript_exon_variant 1472160 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1434 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 959 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 59 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.319G>A rrs_n.319G>A 1 non_coding_transcript_exon_variant 1472164 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1132 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 672 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 31 3) Uncertain significance No change no 1 +Capreomycin rrs n.324A>C rrs_n.324A>C 1 non_coding_transcript_exon_variant 1472169 0 0 0 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1158 2386 False False Inf 0.193753017505121 Inf 0 0 0.00179958946453767 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 693 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0 0 0.00282489773306727 1 0.999573236258028 1 NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.327T>C rrs_n.327T>C 1 non_coding_transcript_exon_variant 1472172 NA 0 0 0 3 35 2046 15448 0.00146412884333821 0.000302040401839334 0.00427278776332334 0.997739456177743 0.996857519632686 0.998424958795015 0.0789473684210526 0.0165864758645295 0.213773291180618 NA NA NA 0 0 0.100032435572105 NA NA NA NA 1065 2386 False True 0.647172182656053 0.127234161115166 2.05585538380989 0 0 0.00180134700867096 0.997739456177743 0.996857519632686 0.998424958795015 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 2 32 1303 8610 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.996297153436704 0.994776671397899 0.997465918686142 0.0588235294117647 0.00720491743904971 0.196773209335575 NA NA NA 0 0 0.108881160679352 NA NA NA NA 608 1774 False True 0 1 1 0 0 0 0 0.412989255564082 0.0479046623388498 1.62219200965145 0 0 0.00282706266083767 0.996297153436704 0.994776671397899 0.997465918686142 235 5) Not assoc w R UP from Uncertain to NotAwR yes 4 +Capreomycin rrs n.-32T>G rrs_n.-32T>G 1 upstream_gene_variant 1471814 1 5 1 4 1 4 2048 15479 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999741652134599 0.999338660174897 0.999929604559257 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 1.8895263671875 0.0383494517213545 19.1050373764475 0.462862503415467 151 2386 False False 1.8895263671875 0.0383494517213545 19.1050373764475 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 1 4 1 4 1304 8638 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999537144179588 0.998815333169806 0.999873873427139 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 1.65605828220858 0.0336017769800931 16.7446524584225 0.505068873201533 105 1774 False False 0 0 0 0 0 0 0 1.65605828220858 0.0336017769800931 16.7446524584225 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999537144179588 0.998815333169806 0.999873873427139 NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.330G>T rrs_n.330G>T 1 non_coding_transcript_exon_variant 1472175 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.332C>T rrs_n.332C>T 1 non_coding_transcript_exon_variant 1472177 1 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1159 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 694 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 39 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.336G>A rrs_n.336G>A 1 non_coding_transcript_exon_variant 1472181 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1356 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 885 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.33C>T rrs_n.33C>T 1 non_coding_transcript_exon_variant 1471878 0 0 0 0 2 3 2047 15480 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.999806239100949 0.999433853882399 0.999960040061829 0.4 0.0527449505263169 0.853367200365326 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1143 2386 False False 5.04152418172936 0.420787897776746 44.0540252618051 0 0 0.00180046780769359 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 3 1303 8639 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.999652858134691 0.998985842622235 0.999928405279598 0.4 0.0527449505263169 0.853367200365326 NA NA NA 0 0 0.707598226178713 NA NA NA NA 680 1774 False False 0 0 0 0 0 0 0 4.42005628037861 0.368763684490018 38.622243637886 0 0 0.00282706266083767 0.999652858134691 0.998985842622235 0.999928405279598 38 3) Uncertain significance No change no 1 +Capreomycin rrs n.340C>T rrs_n.340C>T 1 non_coding_transcript_exon_variant 1472185 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1109 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 649 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.349G>A rrs_n.349G>A 1 non_coding_transcript_exon_variant 1472194 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 8 3) Uncertain significance No change no 1 +Capreomycin rrs n.-34C>A rrs_n.-34C>A 1 upstream_gene_variant 1471812 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.358G>A rrs_n.358G>A 1 non_coding_transcript_exon_variant 1472203 2 1 0 1 3 14 2046 15469 0.00146412884333821 0.000302040401839334 0.00427278776332334 0.999095782471097 0.998483341560662 0.999505570487652 0.176470588235294 0.0379850680706259 0.434317872844283 0 0 0.975 0 0 0.231635761650116 0 0 293.534810415552 1 619.5 2386 False False 1.62012987012987 0.298292433443589 5.81217329995604 0 0 0.00180134700867096 0.999095782471097 0.998483341560662 0.999505570487652 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 11 1303 8631 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.998727146493867 0.997723657451287 0.999364430275444 0.153846153846153 0.0192066719825284 0.454471055676557 NA NA NA 0 0 0.284914152918154 NA NA NA NA 582 1774 False False 0 0 0 0 0 0 0 1.20435358961836 0.129545350164501 5.52664356497091 0 0 0.00282706266083767 0.998727146493867 0.997723657451287 0.999364430275444 125 3) Uncertain significance No change no 1 +Capreomycin rrs n.358G>T rrs_n.358G>T 1 non_coding_transcript_exon_variant 1472203 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1211 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.365A>C rrs_n.365A>C 1 non_coding_transcript_exon_variant 1472210 1 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1321 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 851 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 35 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.365A>G rrs_n.365A>G 1 non_coding_transcript_exon_variant 1472210 1 1 0 1 1 3 2048 15480 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999806239100949 0.999433853882399 0.999960040061829 0.25 0.00630946320970987 0.805879550316756 0 0 0.975 0 0 0.707598226178713 0 0 293.457028791419 1 619.5 2386 False False 2.51953125 0.047970285762596 31.379124977949 0 0 0.00179958946453767 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 660 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.368G>C rrs_n.368G>C 1 non_coding_transcript_exon_variant 1472213 1 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1277 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 808 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 55 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.370A>G rrs_n.370A>G 1 non_coding_transcript_exon_variant 1472215 1 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1039 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 583 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 38 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.377G>A rrs_n.377G>A 1 non_coding_transcript_exon_variant 1472222 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1093 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 634 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 21 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.378C>G rrs_n.378C>G 1 non_coding_transcript_exon_variant 1472223 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1278 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 809 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.37C>T rrs_n.37C>T 1 non_coding_transcript_exon_variant 1471882 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.380C>A rrs_n.380C>A 1 non_coding_transcript_exon_variant 1472225 NA 0 0 0 0 7 2049 15476 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1174 2386 False True 0 0 5.24430081649792 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 7 1305 8635 0 0 0.00282273611850443 0.999190002314279 0.998331811834773 0.999674278877205 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 708 1774 False True 0 1 1 0 0 0 0 0 0 4.59639609856608 0 0 0.00282273611850443 0.999190002314279 0.998331811834773 0.999674278877205 113 5) Not assoc w R New NotAwR yes 5 +Capreomycin rrs n.382A>C rrs_n.382A>C 1 non_coding_transcript_exon_variant 1472227 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.383G>C rrs_n.383G>C 1 non_coding_transcript_exon_variant 1472228 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1260 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 792 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.384C>T rrs_n.384C>T 1 non_coding_transcript_exon_variant 1472229 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1287 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 819 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 20 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.389T>C rrs_n.389T>C 1 non_coding_transcript_exon_variant 1472234 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1175 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 709 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 31 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.38G>A rrs_n.38G>A 1 non_coding_transcript_exon_variant 1471883 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.391C>G rrs_n.391C>G 1 non_coding_transcript_exon_variant 1472236 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1261 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 793 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 42 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.395G>A rrs_n.395G>A 1 non_coding_transcript_exon_variant 1472240 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1419 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 946 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 56 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.-40_-39insA rrs_n.-40_-39insA 1 upstream_gene_variant 1471806 1 1 0 1 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 293.314465539138 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 800 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance No change no 1 +Capreomycin rrs n.401G>A rrs_n.401G>A 1 non_coding_transcript_exon_variant 1472246 0 0 0 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1075 2386 False False Inf 0.193753017505121 Inf 0 0 0.00179958946453767 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 616 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0 0 0.00282489773306727 1 0.999573236258028 1 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.406G>A rrs_n.406G>A 1 non_coding_transcript_exon_variant 1472251 1 1 0 1 0 16 2049 15467 0 0 0.00179871197794837 0.998966608538396 0.99832237803854 0.999409215770894 0 0 0.205907214207822 0 0 0.975 0 0 0.205907214207822 0 0 293.069285826571 1 619.5 2386 False True 0 0 1.95914192339303 0 0 0.00179871197794837 0.998966608538396 0.99832237803854 0.999409215770894 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 1 0 1 0 16 1305 8626 0 0 0.00282273611850443 0.998148576718352 0.996995141231936 0.998941392909931 0 0 0.205907214207822 0 0 0.975 0 0 0.205907214207822 0 0 256.787955344137 1 503.5 1774 False True 0 1 1 0 0 0 0 0 0 1.71646889297801 0 0 0.00282273611850443 0.998148576718352 0.996995141231936 0.998941392909931 136 5) Not assoc w R New NotAwR yes 5 +Capreomycin rrs n.414C>A rrs_n.414C>A 1 non_coding_transcript_exon_variant 1472259 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1382 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 910 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 47 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.424G>A rrs_n.424G>A 1 non_coding_transcript_exon_variant 1472269 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Capreomycin rrs n.433C>T rrs_n.433C>T 1 non_coding_transcript_exon_variant 1472278 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1420 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 947 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.434T>C rrs_n.434T>C 1 non_coding_transcript_exon_variant 1472279 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1198 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 730 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.43C>G rrs_n.43C>G 1 non_coding_transcript_exon_variant 1471888 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.440A>G rrs_n.440A>G 1 non_coding_transcript_exon_variant 1472285 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1199 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 731 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.444T>G rrs_n.444T>G 1 non_coding_transcript_exon_variant 1472289 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1370 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 901 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.445C>G rrs_n.445C>G 1 non_coding_transcript_exon_variant 1472290 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1262 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 794 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.445C>T rrs_n.445C>T 1 non_coding_transcript_exon_variant 1472290 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1160 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 695 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.447A>G rrs_n.447A>G 1 non_coding_transcript_exon_variant 1472292 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Capreomycin rrs n.453_464delGTCCGGGTTCTCinsCCCT rrs_n.453_464delGTCCGGGTTCTCinsCCCT 1 non_coding_transcript_exon_variant 1472298 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1349 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 879 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.459G>A rrs_n.459G>A 1 non_coding_transcript_exon_variant 1472304 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.45G>A rrs_n.45G>A 1 non_coding_transcript_exon_variant 1471890 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.460T>C rrs_n.460T>C 1 non_coding_transcript_exon_variant 1472305 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1133 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Capreomycin rrs n.462C>T rrs_n.462C>T 1 non_coding_transcript_exon_variant 1472307 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 35.2688392655279 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 2 3) Uncertain significance No change no 1 +Capreomycin rrs n.469_476dupATTGACGG rrs_n.469_476dupATTGACGG 1 non_coding_transcript_exon_variant 1472310 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.469A>G rrs_n.469A>G 1 non_coding_transcript_exon_variant 1472314 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1407 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 934 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.470T>G rrs_n.470T>G 1 non_coding_transcript_exon_variant 1472315 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1134 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 673 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.47G>A rrs_n.47G>A 1 non_coding_transcript_exon_variant 1471892 1 3 0 3 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 18.2980327465689 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 13 3) Uncertain significance No change no 1 +Capreomycin rrs n.492C>G rrs_n.492C>G 1 non_coding_transcript_exon_variant 1472337 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1357 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 886 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.492C>T rrs_n.492C>T 1 non_coding_transcript_exon_variant 1472337 1 367 9 358 11 380 2038 15103 0.00536847242557345 0.00268287699664284 0.0095853329613208 0.975456952786927 0.972896282744132 0.97783677882811 0.0281329923273657 0.0141257815052892 0.0497793124610459 0.0245231607629427 0.0112734933278193 0.0460406992514459 0.0231362467866323 0.0106326891529072 0.0434641255528858 0.186302432552453 0.0843648200554291 0.358478240688192 1.08521618843779e-10 NA NA False True 0.214520169412736 0.105979147807459 0.389173106319511 0.00439667806546165 0.00201235220346398 0.0083297874233843 0.975456952786927 0.972896282744132 0.97783677882811 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 202 4 198 4 206 1301 8436 0.00306513409961685 0.000835757856895071 0.00782921001204628 0.976162925248785 0.972723880917847 0.979275544242492 0.019047619047619 0.0052136252225745 0.0480487829658971 0.0198019801980198 0.00542109301235613 0.0499222058236323 0.019047619047619 0.0052136252225745 0.0480487829658971 0.130994805860293 0.0353071767162073 0.341669853165592 2.21770703002346e-08 NA NA False True 1 1 1 0 0 1 0 0.12590762893368 0.0339162738382121 0.328223624914126 0.00306513409961685 0.000835757856895071 0.00782921001204628 0.976162925248785 0.972723880917847 0.979275544242492 827 Not assoc w R 5) Not assoc w R No change yes 1 +Capreomycin rrs n.493A>G rrs_n.493A>G 1 non_coding_transcript_exon_variant 1472338 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1212 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 744 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 8 3) Uncertain significance No change no 1 +Capreomycin rrs n.499C>T rrs_n.499C>T 1 non_coding_transcript_exon_variant 1472344 NA 0 0 0 0 19 2049 15464 0 0 0.00179871197794837 0.998772847639346 0.998084309989574 0.999261017508711 0 0 0.176466911806965 NA NA NA 0 0 0.176466911806965 NA NA NA NA 1094 2386 False True 0 0 1.61871844867048 0 0 0.00179871197794837 0.998772847639346 0.998084309989574 0.999261017508711 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 18 1305 8624 0 0 0.00282273611850443 0.997917148808146 0.996710187129532 0.998765117784843 0 0 0.185301968137852 NA NA NA 0 0 0.185301968137852 NA NA NA NA 635 1774 False True 0 1 1 0 0 0 0 0 0 1.50540367026396 0 0 0.00282273611850443 0.997917148808146 0.996710187129532 0.998765117784843 100 5) Not assoc w R New NotAwR yes 5 +Capreomycin rrs n.-4T>G rrs_n.-4T>G 1 upstream_gene_variant 1471842 1 15 0 15 0 15 2049 15468 0 0 0.00179871197794837 0.999031195504747 0.998402606935329 0.999457669301639 0 0 0.218019360910534 0 0 0.218019360910534 0 0 0.218019360910534 0 0 2.10669629306639 0.243573292580616 127 2386 False False 0 0 2.10669629306639 0 0 0.00179871197794837 0.999031195504747 0.998402606935329 0.999457669301639 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 0 9 1305 8633 0 0 0.00282273611850443 0.998958574404073 0.998023974495813 0.999523686828456 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.336267116879942 0 0 3.35590194387839 0.616555267033112 114 1774 False False 0 0 0 0 0 0 0 0 0 3.35590194387839 0 0 0.00282273611850443 0.998958574404073 0.998023974495813 0.999523686828456 72 3) Uncertain significance No change no 1 +Capreomycin rrs n.5_6delGTinsTGG rrs_n.5_6delGTinsTGG 1 non_coding_transcript_exon_variant 1471850 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 6 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.500A>G rrs_n.500A>G 1 non_coding_transcript_exon_variant 1472345 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1334 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 864 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.504A>G rrs_n.504A>G 1 non_coding_transcript_exon_variant 1472349 1 1 0 1 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 293.33332543886 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 257.202999238191 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 1 3) Uncertain significance No change no 1 +Capreomycin rrs n.513C>T rrs_n.513C>T 1 non_coding_transcript_exon_variant 1472358 1 16 4 12 4 12 2045 15471 0.00195217179111761 0.00053214923576723 0.00499072666314977 0.999224956403797 0.99864654661041 0.999599461575238 0.25 0.0726620382528822 0.523770819896127 0.25 0.0726620382528822 0.523770819896127 0.25 0.0726620382528822 0.523770819896127 2.52176039119804 0.592180449591412 8.32984255942664 0.107785873500092 37 2386 False False 2.52176039119804 0.592180449591412 8.32984255942664 0.00195217179111761 0.00053214923576723 0.00499072666314977 0.999224956403797 0.99864654661041 0.999599461575238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 12 3) Uncertain significance No change no 1 +Capreomycin rrs n.514A>C rrs_n.514A>C 1 non_coding_transcript_exon_variant 1472359 1 337 19 318 154 344 1895 15139 0.0751586139580283 0.0641131522901867 0.0874370413102569 0.977782083575534 0.975336383166966 0.980045901786096 0.309236947791164 0.268877216617942 0.351879142591183 0.0563798219584569 0.0342819704417137 0.0866461744188973 0.0523415977961432 0.0318036031714826 0.080533327432169 0.477325301604686 0.28287721950367 0.760209883884713 0.000790282273154898 NA NA False True 3.57643431306375 2.91995659851361 4.36443988099046 0.00992685475444096 0.00598689670355109 0.0154587797815589 0.977782083575534 0.975336383166966 0.980045901786096 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 250 13 237 105 246 1200 8396 0.0804597701149425 0.066277055182873 0.0965644338604624 0.971534367044665 0.96780743439222 0.97493865804439 0.299145299145299 0.251692161051626 0.350025104254052 0.052 0.0279748924584405 0.0872801849303546 0.0501930501930501 0.026992967112435 0.0843023401967389 0.383783403656821 0.200714662971516 0.671928950293996 0.00018983549759485 NA NA False True 0 0 0 1 0 1 0 2.98638211382113 2.3339267203015 3.7997266756961 0.010717230008244 0.00571846864272543 0.0182570634240601 0.971534367044665 0.96780743439222 0.97493865804439 1196 Not assoc w R 5) Not assoc w R No change yes 1 +Capreomycin rrs n.514A>T rrs_n.514A>T 1 non_coding_transcript_exon_variant 1472359 1 11 1 10 1 11 2048 15472 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999289543370148 0.998729153244051 0.999645290955256 0.0833333333333333 0.00210759323186022 0.384796165150944 0.0909090909090909 0.00229897221381426 0.412779916988382 0.0833333333333333 0.00210759323186022 0.384796165150944 0.75546875 0.0173996016479282 5.31497583136112 1 619.5 2386 False False 0.686789772727272 0.0159480966540523 4.72976907145362 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999289543370148 0.998729153244051 0.999645290955256 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 8 1305 8634 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 0 0 0.369416647552819 0 0 0.409616397225003 0 0 0.369416647552819 0 0 4.59586391977455 0.604891373466209 109 1774 False False 0 0 0 0 0 0 0 0 0 3.88085962593317 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 18 3) Uncertain significance No change no 1 +Capreomycin rrs n.516C>T rrs_n.516C>T 1 non_coding_transcript_exon_variant 1472361 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.517C>T rrs_n.517C>T 1 non_coding_transcript_exon_variant 1472362 1 453 17 436 24 447 2025 15036 0.0117130307467057 0.00751877980005288 0.0173782172513302 0.971129626041464 0.96836972991497 0.973710555738696 0.0509554140127388 0.0329173541276632 0.0748714484020205 0.0375275938189845 0.0220104633037745 0.0594067164885954 0.0366379310344827 0.0214851596098725 0.0580140952876631 0.28951410125722 0.166725402662674 0.470279577210833 2.81324246537038e-09 NA NA False True 0.39866766094954 0.252099102762668 0.602847995403629 0.00832517140058766 0.00485698216312141 0.0132960447638613 0.971129626041464 0.96836972991497 0.973710555738696 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 375 15 360 21 371 1284 8271 0.0160919540229885 0.00998805276090571 0.0244935402944813 0.957070122656792 0.952581883149609 0.961246799634907 0.0535714285714285 0.0334637421229684 0.0807262762877372 0.04 0.0225576316337111 0.0651164765843785 0.038860103626943 0.0219100204760427 0.0632845834538139 0.26839953271028 0.148164156843773 0.45059807937892 2.73543591785156e-09 NA NA False True 1 1 1 0 0 1 0 0.364618233115852 0.222163200085397 0.568423571940062 0.0115473441108545 0.00647696572309824 0.0189741697362765 0.957070122656792 0.952581883149609 0.961246799634907 514 Not assoc w R Not assoc w R 5) Not assoc w R No change yes 1 +Capreomycin rrs n.51T>C rrs_n.51T>C 1 non_coding_transcript_exon_variant 1471896 0 0 0 0 1 9 2048 15474 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999418717302848 0.998896832459985 0.999734167184357 0.1 0.00252857854446178 0.445016117028195 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1408 2386 False False 0.839518229166666 0.0191442481599193 6.06407759157277 0 0 0.00179958946453767 0.999418717302848 0.998896832459985 0.999734167184357 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 8 1305 8634 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 935 1774 False False 0 0 0 0 0 0 0 0 0 3.88085962593317 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 104 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.529T>C rrs_n.529T>C 1 non_coding_transcript_exon_variant 1472374 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.-52T>G rrs_n.-52T>G 1 upstream_gene_variant 1471794 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1296 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 828 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.533G>T rrs_n.533G>T 1 non_coding_transcript_exon_variant 1472378 0 0 0 0 3 8 2046 15475 0.00146412884333821 0.000302040401839334 0.00427278776332334 0.999483304269198 0.998982158652985 0.999776901906193 0.272727272727272 0.0602177341729066 0.609742559572421 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1371 2386 False False 2.83632697947214 0.484217631242897 11.8242263228461 0 0 0.00180134700867096 0.999483304269198 0.998982158652985 0.999776901906193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 6 1303 8636 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.999305716269382 0.998489453757575 0.999745168847445 0.25 0.0318540262499442 0.650855794412824 NA NA NA 0 0 0.4592581264399 NA NA NA NA 902 1774 False False 0 0 0 0 0 0 0 2.20926068048094 0.217820912027644 12.3689513993417 0 0 0.00282706266083767 0.999305716269382 0.998489453757575 0.999745168847445 95 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.534T>C rrs_n.534T>C 1 non_coding_transcript_exon_variant 1472379 1 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1144 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 681 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 65 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.534T>G rrs_n.534T>G 1 non_coding_transcript_exon_variant 1472379 0 0 0 0 3 10 2046 15473 0.00146412884333821 0.000302040401839334 0.00427278776332334 0.999354130336498 0.998812544515655 0.999690238326549 0.23076923076923 0.0503810734911515 0.53813153923404 NA NA NA 0 0 0.30849710781876 NA NA NA NA 1288 2386 False False 2.26876832844574 0.400873812709015 8.81952171900843 0 0 0.00180134700867096 0.999354130336498 0.998812544515655 0.999690238326549 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 7 1303 8635 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.999190002314279 0.998331811834773 0.999674278877205 0.222222222222222 0.0281449734778982 0.600093573716312 NA NA NA 0 0 0.409616397225003 NA NA NA NA 820 1774 False False 0 0 0 0 0 0 0 1.89343273763841 0.191695673798278 9.95987601380279 0 0 0.00282706266083767 0.999190002314279 0.998331811834773 0.999674278877205 72 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.535G>C rrs_n.535G>C 1 non_coding_transcript_exon_variant 1472380 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1235 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 767 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 40 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.537G>A rrs_n.537G>A 1 non_coding_transcript_exon_variant 1472382 0 0 0 0 3 10 2046 15473 0.00146412884333821 0.000302040401839334 0.00427278776332334 0.999354130336498 0.998812544515655 0.999690238326549 0.23076923076923 0.0503810734911515 0.53813153923404 NA NA NA 0 0 0.30849710781876 NA NA NA NA 1176 2386 False False 2.26876832844574 0.400873812709015 8.81952171900843 0 0 0.00180134700867096 0.999354130336498 0.998812544515655 0.999690238326549 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 7 1303 8635 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.999190002314279 0.998331811834773 0.999674278877205 0.222222222222222 0.0281449734778982 0.600093573716312 NA NA NA 0 0 0.409616397225003 NA NA NA NA 710 1774 False False 0 0 0 0 0 0 0 1.89343273763841 0.191695673798278 9.95987601380279 0 0 0.00282706266083767 0.999190002314279 0.998331811834773 0.999674278877205 88 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.544G>A rrs_n.544G>A 1 non_coding_transcript_exon_variant 1472389 1 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1040 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 584 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 52 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.551A>T rrs_n.551A>T 1 non_coding_transcript_exon_variant 1472396 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1095 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 636 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 61 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.554A>G rrs_n.554A>G 1 non_coding_transcript_exon_variant 1472399 0 0 0 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1223 2386 False False Inf 0.193753017505121 Inf 0 0 0.00179958946453767 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 755 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0 0 0.00282489773306727 1 0.999573236258028 1 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.554A>T rrs_n.554A>T 1 non_coding_transcript_exon_variant 1472399 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.555C>T rrs_n.555C>T 1 non_coding_transcript_exon_variant 1472400 NA 0 0 0 3 23 2046 15460 0.00146412884333821 0.000302040401839334 0.00427278776332334 0.998514499773945 0.997771848972111 0.999058094518622 0.115384615384615 0.0244580753179622 0.301540400107567 NA NA NA 0 0 0.148185128915224 NA NA NA NA 1121 2386 False True 0.985592247864337 0.189274756754247 3.26652734411333 0 0 0.00180134700867096 0.998514499773945 0.997771848972111 0.999058094518622 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 2 20 1303 8622 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.99768572089794 0.996428035548426 0.998585822914007 0.0909090909090909 0.0112055860241509 0.291612741553933 NA NA NA 0 0 0.168433470983085 NA NA NA NA 661 1774 False True 0 1 1 0 0 0 0 0.661703760552571 0.0749039402438469 2.72915498621417 0 0 0.00282706266083767 0.99768572089794 0.996428035548426 0.998585822914007 167 5) Not assoc w R New NotAwR yes 5 +Capreomycin rrs n.556dupT rrs_n.556dupT 1 non_coding_transcript_exon_variant 1472400 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.55C>T rrs_n.55C>T 1 non_coding_transcript_exon_variant 1471900 0 0 0 0 1 9 2048 15474 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999418717302848 0.998896832459985 0.999734167184357 0.1 0.00252857854446178 0.445016117028195 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1236 2386 False False 0.839518229166666 0.0191442481599193 6.06407759157277 0 0 0.00179958946453767 0.999418717302848 0.998896832459985 0.999734167184357 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 8 1305 8634 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 768 1774 False False 0 0 0 0 0 0 0 0 0 3.88085962593317 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 92 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.-55T>G rrs_n.-55T>G 1 upstream_gene_variant 1471791 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1099 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 639 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.560C>T rrs_n.560C>T 1 non_coding_transcript_exon_variant 1472405 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 35.2688392655279 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.567A>C rrs_n.567A>C 1 non_coding_transcript_exon_variant 1472412 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1122 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 662 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 30 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.567A>G rrs_n.567A>G 1 non_coding_transcript_exon_variant 1472412 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1237 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 769 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 13 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.-56T>C rrs_n.-56T>C 1 upstream_gene_variant 1471790 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.570T>G rrs_n.570T>G 1 non_coding_transcript_exon_variant 1472415 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1350 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 880 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 31 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.571C>T rrs_n.571C>T 1 non_coding_transcript_exon_variant 1472416 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1053 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 595 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 14 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.573T>C rrs_n.573T>C 1 non_coding_transcript_exon_variant 1472418 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1322 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 852 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.577T>C rrs_n.577T>C 1 non_coding_transcript_exon_variant 1472422 NA 0 0 0 0 8 2049 15475 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1409 2386 False True 0 0 4.42794679154129 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 7 1305 8635 0 0 0.00282273611850443 0.999190002314279 0.998331811834773 0.999674278877205 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 936 1774 False True 0 1 1 0 0 0 0 0 0 4.59639609856608 0 0 0.00282273611850443 0.999190002314279 0.998331811834773 0.999674278877205 42 5) Not assoc w R New NotAwR yes 5 +Capreomycin rrs n.580T>C rrs_n.580T>C 1 non_coding_transcript_exon_variant 1472425 1 2 0 2 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 0 0 0.841886116991581 0 0 0.521823750104981 0 0 40.2289720864225 1 619.5 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 745 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.581T>G rrs_n.581T>G 1 non_coding_transcript_exon_variant 1472426 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1435 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 960 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.590T>C rrs_n.590T>C 1 non_coding_transcript_exon_variant 1472435 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1279 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 810 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.592T>A rrs_n.592T>A 1 non_coding_transcript_exon_variant 1472437 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1372 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 903 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.593dupT rrs_n.593dupT 1 non_coding_transcript_exon_variant 1472436 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.593T>C rrs_n.593T>C 1 non_coding_transcript_exon_variant 1472438 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1289 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 821 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.594C>T rrs_n.594C>T 1 non_coding_transcript_exon_variant 1472439 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1280 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 811 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.5G>T rrs_n.5G>T 1 non_coding_transcript_exon_variant 1471850 1 7 0 7 0 9 2049 15474 0 0 0.00179871197794837 0.999418717302848 0.998896832459985 0.999734167184357 0 0 0.336267116879942 0 0 0.409616397225003 0 0 0.336267116879942 0 0 5.24362312096424 1 194.5 2386 False False 0 0 3.82923083971975 0 0 0.00179871197794837 0.999418717302848 0.998896832459985 0.999734167184357 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 887 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 13 3) Uncertain significance No change no 1 +Capreomycin rrs n.601T>A rrs_n.601T>A 1 non_coding_transcript_exon_variant 1472446 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1177 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 711 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.602C>T rrs_n.602C>T 1 non_coding_transcript_exon_variant 1472447 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1161 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 696 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.603T>C rrs_n.603T>C 1 non_coding_transcript_exon_variant 1472448 1 2 0 2 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 40.2315677803598 1 619.5 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 257.173353425001 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 1 3) Uncertain significance No change no 1 +Capreomycin rrs n.605A>G rrs_n.605A>G 1 non_coding_transcript_exon_variant 1472450 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1313 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 844 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.606C>G rrs_n.606C>G 1 non_coding_transcript_exon_variant 1472451 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1244 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 777 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.607G>A rrs_n.607G>A 1 non_coding_transcript_exon_variant 1472452 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1290 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 822 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.616G>C rrs_n.616G>C 1 non_coding_transcript_exon_variant 1472461 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1096 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 637 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.617T>C rrs_n.617T>C 1 non_coding_transcript_exon_variant 1472462 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1041 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 585 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.619A>G rrs_n.619A>G 1 non_coding_transcript_exon_variant 1472464 1 0 0 0 0 6 2049 15477 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1436 2386 False False 0 0 6.41986758323506 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 1305 8636 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 961 1774 False False 0 0 0 0 0 0 0 0 0 5.62683462374212 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.626G>A rrs_n.626G>A 1 non_coding_transcript_exon_variant 1472471 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1263 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 795 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.628G>T rrs_n.628G>T 1 non_coding_transcript_exon_variant 1472473 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1213 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 746 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.629C>G rrs_n.629C>G 1 non_coding_transcript_exon_variant 1472474 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1178 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 712 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.633A>C rrs_n.633A>C 1 non_coding_transcript_exon_variant 1472478 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.637G>A rrs_n.637G>A 1 non_coding_transcript_exon_variant 1472482 1 4 0 4 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 11.4504880046624 1 619.5 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 10.0364048825129 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.639A>C rrs_n.639A>C 1 non_coding_transcript_exon_variant 1472484 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1335 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 865 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.639A>T rrs_n.639A>T 1 non_coding_transcript_exon_variant 1472484 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1291 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 823 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.641A>G rrs_n.641A>G 1 non_coding_transcript_exon_variant 1472486 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1042 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 586 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.643dupT rrs_n.643dupT 1 non_coding_transcript_exon_variant 1472487 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 20 3) Uncertain significance No change no 1 +Capreomycin rrs n.644A>G rrs_n.644A>G 1 non_coding_transcript_exon_variant 1472489 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.644A>T rrs_n.644A>T 1 non_coding_transcript_exon_variant 1472489 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1264 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 796 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 5 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.649A>G rrs_n.649A>G 1 non_coding_transcript_exon_variant 1472494 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1238 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 770 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 9 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.649A>T rrs_n.649A>T 1 non_coding_transcript_exon_variant 1472494 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1437 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 962 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.650C>T rrs_n.650C>T 1 non_coding_transcript_exon_variant 1472495 1 1 0 1 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 293.33332543886 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 911 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance No change no 1 +Capreomycin rrs n.651T>A rrs_n.651T>A 1 non_coding_transcript_exon_variant 1472496 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1301 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 833 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.651T>G rrs_n.651T>G 1 non_coding_transcript_exon_variant 1472496 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1076 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 617 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.652G>T rrs_n.652G>T 1 non_coding_transcript_exon_variant 1472497 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1200 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 732 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.653C>T rrs_n.653C>T 1 non_coding_transcript_exon_variant 1472498 1 0 0 0 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1292 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 1305 8637 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 824 1774 False False 0 0 0 0 0 0 0 0 0 7.23014561016525 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 11 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.655G>C rrs_n.655G>C 1 non_coding_transcript_exon_variant 1472500 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 4 3) Uncertain significance No change no 1 +Capreomycin rrs n.656G>C rrs_n.656G>C 1 non_coding_transcript_exon_variant 1472501 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.-65G>A rrs_n.-65G>A 1 upstream_gene_variant 1471781 1 6 0 6 0 7 2049 15476 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 6.41945279027998 1 619.5 2386 False False 0 0 5.24430081649792 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 35.2647591017504 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 6 3) Uncertain significance No change no 1 +Capreomycin rrs n.662C>G rrs_n.662C>G 1 non_coding_transcript_exon_variant 1472507 1 0 0 0 0 7 2049 15476 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1323 2386 False False 0 0 5.24430081649792 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 1305 8636 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 853 1774 False False 0 0 0 0 0 0 0 0 0 5.62683462374212 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 43 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.662C>T rrs_n.662C>T 1 non_coding_transcript_exon_variant 1472507 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1224 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 756 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.663T>C rrs_n.663T>C 1 non_coding_transcript_exon_variant 1472508 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1110 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 650 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.66C>A rrs_n.66C>A 1 non_coding_transcript_exon_variant 1471911 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1410 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 937 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 27 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.672T>A rrs_n.672T>A 1 non_coding_transcript_exon_variant 1472517 1 0 0 0 0 11 2049 15472 0 0 0.00179871197794837 0.999289543370148 0.998729153244051 0.999645290955256 0 0 0.284914152918154 NA NA NA 0 0 0.284914152918154 NA NA NA NA 1077 2386 False False 0 0 3.01101772028239 0 0 0.00179871197794837 0.999289543370148 0.998729153244051 0.999645290955256 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 9 1305 8633 0 0 0.00282273611850443 0.998958574404073 0.998023974495813 0.999523686828456 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 618 1774 False False 0 0 0 0 0 0 0 0 0 3.35590194387839 0 0 0.00282273611850443 0.998958574404073 0.998023974495813 0.999523686828456 72 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.673G>A rrs_n.673G>A 1 non_coding_transcript_exon_variant 1472518 1 1 0 1 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 293.33332543886 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 834 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 4 3) Uncertain significance No change no 1 +Capreomycin rrs n.673G>C rrs_n.673G>C 1 non_coding_transcript_exon_variant 1472518 1 0 0 0 0 6 2049 15477 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1201 2386 False False 0 0 6.41986758323506 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 1305 8637 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 733 1774 False False 0 0 0 0 0 0 0 0 0 7.23014561016525 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.673G>T rrs_n.673G>T 1 non_coding_transcript_exon_variant 1472518 1 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1383 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 912 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 66 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.-67T>C rrs_n.-67T>C 1 upstream_gene_variant 1471779 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Capreomycin rrs n.685G>A rrs_n.685G>A 1 non_coding_transcript_exon_variant 1472530 0 0 0 0 3 22 2046 15461 0.00146412884333821 0.000302040401839334 0.00427278776332334 0.998579086740295 0.997849505931622 0.999109313702287 0.12 0.0254653966477332 0.312190307286235 NA NA NA 0 0 0.154372512815574 NA NA NA NA 1186 2386 False False 1.03045854438816 0.197288090832389 3.43439799721578 0 0 0.00180134700867096 0.998579086740295 0.997849505931622 0.999109313702287 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 19 1303 8623 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.997801434853043 0.996568788084241 0.998675817295743 0.0952380952380952 0.0117493178844458 0.303774406913924 NA NA NA 0 0 0.176466911806965 NA NA NA NA 719 1774 False False 0 0 0 0 0 0 0 0.696611059498323 0.0785909736997097 2.89298915411034 0 0 0.00282706266083767 0.997801434853043 0.996568788084241 0.998675817295743 163 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.-68G>C rrs_n.-68G>C 1 upstream_gene_variant 1471778 1 4 0 4 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 11.4504880046624 1 619.5 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.692C>T rrs_n.692C>T 1 non_coding_transcript_exon_variant 1472537 0 0 0 0 2 13 2047 15470 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.999160369437447 0.998564634148971 0.999552858749588 0.133333333333333 0.0165759134400836 0.404602696603372 NA NA NA 0 0 0.24705263800047 NA NA NA NA 1302 2386 False False 1.16267708842208 0.127270193913844 5.14111081474129 0 0 0.00180046780769359 0.999160369437447 0.998564634148971 0.999552858749588 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 11 1304 8631 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.998727146493867 0.997723657451287 0.999364430275444 0.0833333333333333 0.00210759323186022 0.384796165150944 NA NA NA 0 0 0.284914152918154 NA NA NA NA 835 1774 False False 0 0 0 0 0 0 0 0.601715002788622 0.0139718970364074 4.14634229926157 0 0 0.00282489773306727 0.998727146493867 0.997723657451287 0.999364430275444 141 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.696T>G rrs_n.696T>G 1 non_coding_transcript_exon_variant 1472541 0 0 0 0 2 9 2047 15474 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.999418717302848 0.998896832459985 0.999734167184357 0.181818181818181 0.0228311982999596 0.517755852360172 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1145 2386 False False 1.67985670086305 0.176481355552764 8.12348790592676 0 0 0.00180046780769359 0.999418717302848 0.998896832459985 0.999734167184357 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 7 1304 8635 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999190002314279 0.998331811834773 0.999674278877205 0.125 0.0031597235312519 0.526509670875206 NA NA NA 0 0 0.409616397225003 NA NA NA NA 682 1774 False False 0 0 0 0 0 0 0 0.945990359333917 0.0209738740409183 7.37396279411377 0 0 0.00282489773306727 0.999190002314279 0.998331811834773 0.999674278877205 40 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.698T>C rrs_n.698T>C 1 non_coding_transcript_exon_variant 1472543 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1135 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.699C>A rrs_n.699C>A 1 non_coding_transcript_exon_variant 1472544 1 0 0 0 0 7 2049 15476 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1136 2386 False False 0 0 5.24430081649792 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 1305 8637 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 674 1774 False False 0 0 0 0 0 0 0 0 0 7.23014561016525 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 160 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.699C>G rrs_n.699C>G 1 non_coding_transcript_exon_variant 1472544 0 0 0 0 2 7 2047 15476 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.999547891235548 0.999068706427379 0.999818210125054 0.222222222222222 0.0281449734778982 0.600093573716312 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1314 2386 False False 2.16009491241538 0.218788540583066 11.351113176461 0 0 0.00180046780769359 0.999547891235548 0.999068706427379 0.999818210125054 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 6 1304 8636 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999305716269382 0.998489453757575 0.999745168847445 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA 0 0 0.4592581264399 NA NA NA NA 845 1774 False False 0 0 0 0 0 0 0 1.10378323108384 0.0239783465953148 9.10896322125085 0 0 0.00282489773306727 0.999305716269382 0.998489453757575 0.999745168847445 11 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.699C>T rrs_n.699C>T 1 non_coding_transcript_exon_variant 1472544 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Capreomycin rrs n.69A>G rrs_n.69A>G 1 non_coding_transcript_exon_variant 1471914 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1336 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 866 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.-69C>A rrs_n.-69C>A 1 upstream_gene_variant 1471777 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.-69C>T rrs_n.-69C>T 1 upstream_gene_variant 1471777 1 2 0 2 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 0 0 0.841886116991581 0 0 0.521823750104981 0 0 40.2289720864225 1 619.5 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 5 1305 8637 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 0 0 0.521823750104981 0 0 0.841886116991581 0 0 0.521823750104981 0 0 35.2565987679719 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 7.23014561016525 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 16 3) Uncertain significance No change no 1 +Capreomycin rrs n.700A>T rrs_n.700A>T 1 non_coding_transcript_exon_variant 1472545 0 0 0 0 2 14 2047 15469 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.999095782471097 0.998483341560662 0.999505570487652 0.125 0.0155136038154138 0.383476236849263 NA NA NA 0 0 0.231635761650116 NA NA NA NA 1315 2386 False False 1.07955893642263 0.118984769392524 4.70616521734574 0 0 0.00180046780769359 0.999095782471097 0.998483341560662 0.999505570487652 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 11 1304 8631 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.998727146493867 0.997723657451287 0.999364430275444 0.0833333333333333 0.00210759323186022 0.384796165150944 NA NA NA 0 0 0.284914152918154 NA NA NA NA 846 1774 False False 0 0 0 0 0 0 0 0.601715002788622 0.0139718970364074 4.14634229926157 0 0 0.00282489773306727 0.998727146493867 0.997723657451287 0.999364430275444 174 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.704G>A rrs_n.704G>A 1 non_coding_transcript_exon_variant 1472549 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1245 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 778 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 15 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.708C>T rrs_n.708C>T 1 non_coding_transcript_exon_variant 1472553 1 3 0 3 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 18.2980327465689 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 35.2688392655279 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 3 3) Uncertain significance No change no 1 +Capreomycin rrs n.-70G>C rrs_n.-70G>C 1 upstream_gene_variant 1471776 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance No change no 1 +Capreomycin rrs n.712G>A rrs_n.712G>A 1 non_coding_transcript_exon_variant 1472557 0 0 0 0 3 18 2046 15465 0.00146412884333821 0.000302040401839334 0.00427278776332334 0.998837434605696 0.998163265407594 0.999310849114122 0.142857142857142 0.0304889676215155 0.363423987016981 NA NA NA 0 0 0.185301968137852 NA NA NA NA 1324 2386 False False 1.25977517106549 0.237487453285484 4.32104124310445 0 0 0.00180134700867096 0.998837434605696 0.998163265407594 0.999310849114122 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 13 1303 8629 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.998495718583661 0.997429006709305 0.999198798037271 0.133333333333333 0.0165759134400836 0.404602696603372 NA NA NA 0 0 0.24705263800047 NA NA NA NA 854 1774 False False 0 0 0 0 0 0 0 1.01883228053604 0.111491999302043 4.50815235822369 0 0 0.00282706266083767 0.998495718583661 0.997429006709305 0.999198798037271 68 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.713G>A rrs_n.713G>A 1 non_coding_transcript_exon_variant 1472558 1 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1111 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 651 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 13 3) Uncertain significance No change no 1 +Capreomycin rrs n.717C>T rrs_n.717C>T 1 non_coding_transcript_exon_variant 1472562 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.721G>A rrs_n.721G>A 1 non_coding_transcript_exon_variant 1472566 1 0 0 0 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1054 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 596 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 159 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.724G>A rrs_n.724G>A 1 non_coding_transcript_exon_variant 1472569 1 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1214 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 747 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 13 3) Uncertain significance No change no 1 +Capreomycin rrs n.725G>A rrs_n.725G>A 1 non_coding_transcript_exon_variant 1472570 0 0 0 0 2 15 2047 15468 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.999031195504747 0.998402606935329 0.999457669301639 0.117647058823529 0.0145793168403025 0.36440916210125 NA NA NA 0 0 0.218019360910534 NA NA NA NA 1303 2386 False False 1.00752320468979 0.111713648797946 4.33756144038052 0 0 0.00180046780769359 0.999031195504747 0.998402606935329 0.999457669301639 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 11 1303 8631 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.998727146493867 0.997723657451287 0.999364430275444 0.153846153846153 0.0192066719825284 0.454471055676557 NA NA NA 0 0 0.284914152918154 NA NA NA NA 836 1774 False False 0 0 0 0 0 0 0 1.20435358961836 0.129545350164501 5.52664356497091 0 0 0.00282706266083767 0.998727146493867 0.997723657451287 0.999364430275444 37 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.726G>A rrs_n.726G>A 1 non_coding_transcript_exon_variant 1472571 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1411 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 938 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.726G>C rrs_n.726G>C 1 non_coding_transcript_exon_variant 1472571 0 0 0 0 2 22 2047 15461 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.998579086740295 0.997849505931622 0.999109313702287 0.0833333333333333 0.0102563412812501 0.269972801557603 NA NA NA 0 0 0.154372512815574 NA NA NA NA 1412 2386 False False 0.686636763334369 0.078212853655083 2.79656333528623 0 0 0.00180046780769359 0.998579086740295 0.997849505931622 0.999109313702287 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 17 1303 8625 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.998032862763249 0.996852284939993 0.998853665542417 0.105263157894736 0.0130121643717774 0.331376664456765 NA NA NA 0 0 0.195064322969093 NA NA NA NA 939 1774 False False 0 0 0 0 0 0 0 0.778745880547153 0.0871700349829632 3.28674418141717 0 0 0.00282706266083767 0.998032862763249 0.996852284939993 0.998853665542417 235 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.728C>T rrs_n.728C>T 1 non_coding_transcript_exon_variant 1472573 1 0 0 0 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1162 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 697 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 44 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.730C>T rrs_n.730C>T 1 non_coding_transcript_exon_variant 1472575 0 0 0 0 2 0 2047 15483 0.000976085895558809 0.000118230396782607 0.00352146535805941 1 0.999761774846946 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1325 2386 False False Inf 1.41952099860885 Inf 0 0 0.00180046780769359 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 1303 8642 0.00153256704980842 0.000185654897205815 0.00552508794778556 1 0.999573236258028 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 855 1774 False False 0 0 0 0 0 0 0 Inf 1.24419098853007 Inf 0 0 0.00282706266083767 1 0.999573236258028 1 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.734G>A rrs_n.734G>A 1 non_coding_transcript_exon_variant 1472579 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1043 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 587 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.734G>C rrs_n.734G>C 1 non_coding_transcript_exon_variant 1472579 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1066 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 100 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.734G>T rrs_n.734G>T 1 non_coding_transcript_exon_variant 1472579 0 0 0 0 3 14 2046 15469 0.00146412884333821 0.000302040401839334 0.00427278776332334 0.999095782471097 0.998483341560662 0.999505570487652 0.176470588235294 0.0379850680706259 0.434317872844283 NA NA NA 0 0 0.231635761650116 NA NA NA NA 1358 2386 False False 1.62012987012987 0.298292433443589 5.81217329995604 0 0 0.00180134700867096 0.999095782471097 0.998483341560662 0.999505570487652 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 10 1303 8632 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.99884286044897 0.997873012135272 0.999444971558315 0.166666666666666 0.0208625254600923 0.484137748685967 NA NA NA 0 0 0.30849710781876 NA NA NA NA 888 1774 False False 0 0 0 0 0 0 0 1.32494244052187 0.141022691102851 6.22733061547632 0 0 0.00282706266083767 0.99884286044897 0.997873012135272 0.999444971558315 152 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.735C>A rrs_n.735C>A 1 non_coding_transcript_exon_variant 1472580 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1438 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 963 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.735C>G rrs_n.735C>G 1 non_coding_transcript_exon_variant 1472580 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Capreomycin rrs n.735C>T rrs_n.735C>T 1 non_coding_transcript_exon_variant 1472580 1 1 0 1 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 293.33332543886 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 97 3) Uncertain significance No change no 1 +Capreomycin rrs n.736A>C rrs_n.736A>C 1 non_coding_transcript_exon_variant 1472581 1 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1137 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 675 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 23 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.736A>T rrs_n.736A>T 1 non_coding_transcript_exon_variant 1472581 NA 0 0 0 3 22 2046 15461 0.00146412884333821 0.000302040401839334 0.00427278776332334 0.998579086740295 0.997849505931622 0.999109313702287 0.12 0.0254653966477332 0.312190307286235 NA NA NA 0 0 0.154372512815574 NA NA NA NA 1225 2386 False True 1.03045854438816 0.197288090832389 3.43439799721578 0 0 0.00180134700867096 0.998579086740295 0.997849505931622 0.999109313702287 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 2 16 1303 8626 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.998148576718352 0.996995141231936 0.998941392909931 0.111111111111111 0.0137512156643644 0.347120438608672 NA NA NA 0 0 0.205907214207822 NA NA NA NA 757 1774 False True 0 1 1 0 0 0 0 0.827513430544896 0.0922009300272039 3.52617264127021 0 0 0.00282706266083767 0.998148576718352 0.996995141231936 0.998941392909931 219 5) Not assoc w R UP from Uncertain to NotAwR yes 4 +Capreomycin rrs n.737G>A rrs_n.737G>A 1 non_coding_transcript_exon_variant 1472582 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1316 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 847 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.738T>A rrs_n.738T>A 1 non_coding_transcript_exon_variant 1472583 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1055 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 597 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.739A>T rrs_n.739A>T 1 non_coding_transcript_exon_variant 1472584 1 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1112 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 652 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 23 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.73A>T rrs_n.73A>T 1 non_coding_transcript_exon_variant 1471918 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1398 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 927 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.746G>A rrs_n.746G>A 1 non_coding_transcript_exon_variant 1472591 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1337 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 867 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 7 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.-74delG rrs_n.-74delG 1 upstream_gene_variant 1471771 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1217 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 749 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 11 3) Uncertain significance No change no 1 +Capreomycin rrs n.-74G>T rrs_n.-74G>T 1 upstream_gene_variant 1471772 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 8 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.751G>T rrs_n.751G>T 1 non_coding_transcript_exon_variant 1472596 1 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1338 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 868 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 29 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.752G>A rrs_n.752G>A 1 non_coding_transcript_exon_variant 1472597 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1187 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 720 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 6 3) Uncertain significance No change no 1 +Capreomycin rrs n.753A>C rrs_n.753A>C 1 non_coding_transcript_exon_variant 1472598 0 0 0 0 3 19 2046 15464 0.00146412884333821 0.000302040401839334 0.00427278776332334 0.998772847639346 0.998084309989574 0.999261017508711 0.136363636363636 0.0290558511287467 0.349122097257408 NA NA NA 0 0 0.176466911806965 NA NA NA NA 1123 2386 False False 1.19339404229047 0.225977159851307 4.05946620464024 0 0 0.00180134700867096 0.998772847639346 0.998084309989574 0.999261017508711 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 14 1303 8628 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.998380004628558 0.99728341538717 0.999114059339894 0.125 0.0155136038154138 0.383476236849263 NA NA NA 0 0 0.231635761650116 NA NA NA NA 663 1774 False False 0 0 0 0 0 0 0 0.945948909110843 0.104228363937722 4.1262852933177 0 0 0.00282706266083767 0.998380004628558 0.99728341538717 0.999114059339894 219 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.753A>T rrs_n.753A>T 1 non_coding_transcript_exon_variant 1472598 1 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1138 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 676 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 33 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.754G>A rrs_n.754G>A 1 non_coding_transcript_exon_variant 1472599 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1304 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 837 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.754G>T rrs_n.754G>T 1 non_coding_transcript_exon_variant 1472599 1 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1202 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 734 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 174 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.762G>A rrs_n.762G>A 1 non_coding_transcript_exon_variant 1472607 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1188 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 721 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 14 3) Uncertain significance No change no 1 +Capreomycin rrs n.763T>C rrs_n.763T>C 1 non_coding_transcript_exon_variant 1472608 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.767G>T rrs_n.767G>T 1 non_coding_transcript_exon_variant 1472612 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1044 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 588 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 7 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.769G>T rrs_n.769G>T 1 non_coding_transcript_exon_variant 1472614 1 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1373 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 904 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 32 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.771G>A rrs_n.771G>A 1 non_coding_transcript_exon_variant 1472616 0 0 0 0 2 16 2047 15467 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.998966608538396 0.99832237803854 0.999409215770894 0.111111111111111 0.0137512156643644 0.347120438608672 NA NA NA 0 0 0.205907214207822 NA NA NA NA 1421 2386 False False 0.944491939423546 0.105277647177081 4.02169809685859 0 0 0.00180046780769359 0.998966608538396 0.99832237803854 0.999409215770894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 13 1303 8629 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.998495718583661 0.997429006709305 0.999198798037271 0.133333333333333 0.0165759134400836 0.404602696603372 NA NA NA 0 0 0.24705263800047 NA NA NA NA 948 1774 False False 0 0 0 0 0 0 0 1.01883228053604 0.111491999302043 4.50815235822369 0 0 0.00282706266083767 0.998495718583661 0.997429006709305 0.999198798037271 217 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.78_80delTCTinsCC rrs_n.78_80delTCTinsCC 1 non_coding_transcript_exon_variant 1471923 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1146 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 683 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.78T>C rrs_n.78T>C 1 non_coding_transcript_exon_variant 1471923 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1359 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 889 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 5 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.-78T>C rrs_n.-78T>C 1 upstream_gene_variant 1471768 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.799C>A rrs_n.799C>A 1 non_coding_transcript_exon_variant 1472644 1 9 0 9 0 9 2049 15474 0 0 0.00179871197794837 0.999418717302848 0.998896832459985 0.999734167184357 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.336267116879942 0 0 3.82923083971975 0.610732075631022 170 2386 False False 0 0 3.82923083971975 0 0 0.00179871197794837 0.999418717302848 0.998896832459985 0.999734167184357 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 0 8 1305 8634 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 3.88085962593317 0.607688893937294 111 1774 False False 0 0 0 0 0 0 0 0 0 3.88085962593317 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 3 3) Uncertain significance No change no 1 +Capreomycin rrs n.799C>T rrs_n.799C>T 1 non_coding_transcript_exon_variant 1472644 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1422 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 949 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 14 3) Uncertain significance No change no 1 +Capreomycin rrs n.808C>T rrs_n.808C>T 1 non_coding_transcript_exon_variant 1472653 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Capreomycin rrs n.80T>C rrs_n.80T>C 1 non_coding_transcript_exon_variant 1471925 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1246 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 779 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.810G>A rrs_n.810G>A 1 non_coding_transcript_exon_variant 1472655 1 0 0 0 0 8 2049 15475 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1203 2386 False False 0 0 4.42794679154129 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 1305 8637 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 735 1774 False False 0 0 0 0 0 0 0 0 0 7.23014561016525 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 39 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.810G>T rrs_n.810G>T 1 non_coding_transcript_exon_variant 1472655 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1423 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 950 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 43 3) Uncertain significance No change no 1 +Capreomycin rrs n.813G>A rrs_n.813G>A 1 non_coding_transcript_exon_variant 1472658 1 0 0 0 0 7 2049 15476 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1424 2386 False False 0 0 5.24430081649792 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 951 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 32 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.814G>A rrs_n.814G>A 1 non_coding_transcript_exon_variant 1472659 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1097 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 638 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.815T>C rrs_n.815T>C 1 non_coding_transcript_exon_variant 1472660 1 0 0 0 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1124 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 1305 8637 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 664 1774 False False 0 0 0 0 0 0 0 0 0 7.23014561016525 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 40 3) Uncertain significance No change no 1 +Capreomycin rrs n.816A>G rrs_n.816A>G 1 non_coding_transcript_exon_variant 1472661 1 0 0 0 0 8 2049 15475 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1326 2386 False False 0 0 4.42794679154129 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 1305 8637 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 856 1774 False False 0 0 0 0 0 0 0 0 0 7.23014561016525 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 37 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.81C>T rrs_n.81C>T 1 non_coding_transcript_exon_variant 1471926 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1179 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 713 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.820G>A rrs_n.820G>A 1 non_coding_transcript_exon_variant 1472665 1 0 0 0 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1293 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 825 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.824_825insTAGA rrs_n.824_825insTAGA 1 non_coding_transcript_exon_variant 1472669 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1265 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 797 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.824_825insTAGG rrs_n.824_825insTAGG 1 non_coding_transcript_exon_variant 1472669 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1139 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 677 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.828T>A rrs_n.828T>A 1 non_coding_transcript_exon_variant 1472673 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1125 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 665 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.828T>C rrs_n.828T>C 1 non_coding_transcript_exon_variant 1472673 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1147 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 684 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.829T>A rrs_n.829T>A 1 non_coding_transcript_exon_variant 1472674 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1247 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 780 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.-82C>T rrs_n.-82C>T 1 upstream_gene_variant 1471764 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.830T>A rrs_n.830T>A 1 non_coding_transcript_exon_variant 1472675 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1126 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 666 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.830T>C rrs_n.830T>C 1 non_coding_transcript_exon_variant 1472675 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1215 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 748 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 10 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.830T>G rrs_n.830T>G 1 non_coding_transcript_exon_variant 1472675 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1360 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 890 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.832C>A rrs_n.832C>A 1 non_coding_transcript_exon_variant 1472677 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1339 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 869 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 7 3) Uncertain significance No change no 1 +Capreomycin rrs n.833_834delTTinsGCC rrs_n.833_834delTTinsGCC 1 non_coding_transcript_exon_variant 1472678 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1327 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 857 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 2 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.833T>G rrs_n.833T>G 1 non_coding_transcript_exon_variant 1472678 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1413 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 940 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.834T>C rrs_n.834T>C 1 non_coding_transcript_exon_variant 1472679 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1294 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 826 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.836C>G rrs_n.836C>G 1 non_coding_transcript_exon_variant 1472681 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.837T>A rrs_n.837T>A 1 non_coding_transcript_exon_variant 1472682 1 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1078 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 619 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 10 3) Uncertain significance No change no 1 +Capreomycin rrs n.837T>G rrs_n.837T>G 1 non_coding_transcript_exon_variant 1472682 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1340 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 870 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance No change no 1 +Capreomycin rrs n.838T>C rrs_n.838T>C 1 non_coding_transcript_exon_variant 1472683 1 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1127 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 667 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 10 3) Uncertain significance No change no 1 +Capreomycin rrs n.839_845delGGGATCCinsA rrs_n.839_845delGGGATCCinsA 1 non_coding_transcript_exon_variant 1472684 1 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1248 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 781 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.839_845delGGGATCCinsTA rrs_n.839_845delGGGATCCinsTA 1 non_coding_transcript_exon_variant 1472684 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1204 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 736 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.840G>T rrs_n.840G>T 1 non_coding_transcript_exon_variant 1472685 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1266 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 798 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.841G>T rrs_n.841G>T 1 non_coding_transcript_exon_variant 1472686 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1305 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 838 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 1 3) Uncertain significance No change no 1 +Capreomycin rrs n.842A>G rrs_n.842A>G 1 non_coding_transcript_exon_variant 1472687 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1341 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 871 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 3 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.842A>T rrs_n.842A>T 1 non_coding_transcript_exon_variant 1472687 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1328 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 858 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 10 3) Uncertain significance No change no 1 +Capreomycin rrs n.845C>T rrs_n.845C>T 1 non_coding_transcript_exon_variant 1472690 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1148 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Capreomycin rrs n.847T>C rrs_n.847T>C 1 non_coding_transcript_exon_variant 1472692 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance No change no 1 +Capreomycin rrs n.850C>T rrs_n.850C>T 1 non_coding_transcript_exon_variant 1472695 1 0 0 0 0 7 2049 15476 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1361 2386 False False 0 0 5.24430081649792 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 891 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.852T>C rrs_n.852T>C 1 non_coding_transcript_exon_variant 1472697 1 0 0 0 0 10 2049 15473 0 0 0.00179871197794837 0.999354130336498 0.998812544515655 0.999690238326549 0 0 0.30849710781876 NA NA NA 0 0 0.30849710781876 NA NA NA NA 1439 2386 False False 0 0 3.37173073063401 0 0 0.00179871197794837 0.999354130336498 0.998812544515655 0.999690238326549 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 7 1305 8635 0 0 0.00282273611850443 0.999190002314279 0.998331811834773 0.999674278877205 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 964 1774 False False 0 0 0 0 0 0 0 0 0 4.59639609856608 0 0 0.00282273611850443 0.999190002314279 0.998331811834773 0.999674278877205 89 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.852T>G rrs_n.852T>G 1 non_coding_transcript_exon_variant 1472697 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1079 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 620 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.856T>A rrs_n.856T>A 1 non_coding_transcript_exon_variant 1472701 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1113 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.859C>T rrs_n.859C>T 1 non_coding_transcript_exon_variant 1472704 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.861C>T rrs_n.861C>T 1 non_coding_transcript_exon_variant 1472706 1 1 0 1 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 293.33332543886 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance No change no 1 +Capreomycin rrs n.868T>C rrs_n.868T>C 1 non_coding_transcript_exon_variant 1472713 0 0 0 0 3 21 2046 15462 0.00146412884333821 0.000302040401839334 0.00427278776332334 0.998643673706646 0.997927454478736 0.999160222740807 0.125 0.0265593149862489 0.323611358188833 NA NA NA 0 0 0.161097615219079 NA NA NA NA 1056 2386 False False 1.0795978215333 0.206008566183672 3.62021227041467 0 0 0.00180134700867096 0.998643673706646 0.997927454478736 0.999160222740807 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 15 1303 8627 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.998264290673455 0.997138824765365 0.999028221442365 0.117647058823529 0.0145793168403025 0.36440916210125 NA NA NA 0 0 0.218019360910534 NA NA NA NA 598 1774 False False 0 0 0 0 0 0 0 0.882783320542338 0.0978469652919409 3.80289192088908 0 0 0.00282706266083767 0.998264290673455 0.997138824765365 0.999028221442365 350 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.869A>G rrs_n.869A>G 1 non_coding_transcript_exon_variant 1472714 1 0 0 0 0 6 2049 15477 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1351 2386 False False 0 0 6.41986758323506 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 1305 8636 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 881 1774 False False 0 0 0 0 0 0 0 0 0 5.62683462374212 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 119 3) Uncertain significance No change no 1 +Capreomycin rrs n.86G>A rrs_n.86G>A 1 non_coding_transcript_exon_variant 1471931 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1163 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.87_89delAGAinsGG rrs_n.87_89delAGAinsGG 1 non_coding_transcript_exon_variant 1471932 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1281 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 812 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.871C>T rrs_n.871C>T 1 non_coding_transcript_exon_variant 1472716 0 0 0 0 3 20 2046 15463 0.00146412884333821 0.000302040401839334 0.00427278776332334 0.998708260672996 0.998005714908558 0.999210799130878 0.130434782608695 0.0277515074227932 0.335889137537121 NA NA NA 0 0 0.168433470983085 NA NA NA NA 1239 2386 False False 1.13365102639296 0.215534410502353 3.82744775866749 0 0 0.00180134700867096 0.998708260672996 0.998005714908558 0.999210799130878 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 14 1303 8628 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.998380004628558 0.99728341538717 0.999114059339894 0.125 0.0155136038154138 0.383476236849263 NA NA NA 0 0 0.231635761650116 NA NA NA NA 771 1774 False False 0 0 0 0 0 0 0 0.945948909110843 0.104228363937722 4.1262852933177 0 0 0.00282706266083767 0.998380004628558 0.99728341538717 0.999114059339894 343 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.876C>A rrs_n.876C>A 1 non_coding_transcript_exon_variant 1472721 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.878G>A rrs_n.878G>A 1 non_coding_transcript_exon_variant 1472723 1 48 0 48 0 49 2049 15434 0 0 0.00179871197794837 0.99683523864884 0.995818150752832 0.99765780280622 0 0 0.0725192636642774 0 0 0.0739727853472802 0 0 0.0725192636642774 0 0 0.602325030461229 0.00527553987757654 17 2386 False False 0 0 0.589563646597164 0 0 0.00179871197794837 0.99683523864884 0.995818150752832 0.99765780280622 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 0 10 1305 8632 0 0 0.00282273611850443 0.99884286044897 0.997873012135272 0.999444971558315 0 0 0.30849710781876 0 0 0.336267116879942 0 0 0.30849710781876 0 0 3.35551330064442 0.616563294512695 115 1774 False False 0 0 0 0 0 0 0 0 0 2.9548002607889 0 0 0.00282273611850443 0.99884286044897 0.997873012135272 0.999444971558315 40 3) Uncertain significance No change no 1 +Capreomycin rrs n.887G>A rrs_n.887G>A 1 non_coding_transcript_exon_variant 1472732 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Capreomycin rrs n.887G>T rrs_n.887G>T 1 non_coding_transcript_exon_variant 1472732 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.888G>A rrs_n.888G>A 1 non_coding_transcript_exon_variant 1472733 1 0 0 0 0 12 2049 15471 0 0 0.00179871197794837 0.999224956403797 0.99864654661041 0.999599461575238 0 0 0.264648469397051 NA NA NA 0 0 0.264648469397051 NA NA NA NA 1180 2386 False False 0 0 2.71972624224414 0 0 0.00179871197794837 0.999224956403797 0.99864654661041 0.999599461575238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 9 1305 8633 0 0 0.00282273611850443 0.998958574404073 0.998023974495813 0.999523686828456 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 714 1774 False False 0 0 0 0 0 0 0 0 0 3.35590194387839 0 0 0.00282273611850443 0.998958574404073 0.998023974495813 0.999523686828456 346 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.888G>C rrs_n.888G>C 1 non_coding_transcript_exon_variant 1472733 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1384 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 913 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 27 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.889C>T rrs_n.889C>T 1 non_coding_transcript_exon_variant 1472734 0 0 0 0 1 16 2048 15467 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.998966608538396 0.99832237803854 0.999409215770894 0.0588235294117647 0.00148817439126663 0.28688939666722 NA NA NA 0 0 0.205907214207822 NA NA NA NA 1267 2386 False True 0.472015380859375 0.0112534702075532 3.04146681118005 0 0 0.00179958946453767 0.998966608538396 0.99832237803854 0.999409215770894 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 11 1305 8631 0 0 0.00282273611850443 0.998727146493867 0.997723657451287 0.999364430275444 0 0 0.284914152918154 NA NA NA 0 0 0.284914152918154 NA NA NA NA 799 1774 False True 0 1 1 0 0 0 0 0 0 2.63876604338672 0 0 0.00282273611850443 0.998727146493867 0.997723657451287 0.999364430275444 53 5) Not assoc w R New NotAwR yes 5 +Capreomycin rrs n.891G>A rrs_n.891G>A 1 non_coding_transcript_exon_variant 1472736 1 5 0 5 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 8.24895966345574 1 194.5 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 1305 8637 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 7.23014561016525 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 7.23014561016525 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 11 3) Uncertain significance No change no 1 +Capreomycin rrs n.896G>A rrs_n.896G>A 1 non_coding_transcript_exon_variant 1472741 0 0 0 0 1 16 2048 15467 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.998966608538396 0.99832237803854 0.999409215770894 0.0588235294117647 0.00148817439126663 0.28688939666722 NA NA NA 0 0 0.205907214207822 NA NA NA NA 1189 2386 False True 0.472015380859375 0.0112534702075532 3.04146681118005 0 0 0.00179958946453767 0.998966608538396 0.99832237803854 0.999409215770894 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 11 1305 8631 0 0 0.00282273611850443 0.998727146493867 0.997723657451287 0.999364430275444 0 0 0.284914152918154 NA NA NA 0 0 0.284914152918154 NA NA NA NA 722 1774 False True 0 1 1 0 0 0 0 0 0 2.63876604338672 0 0 0.00282273611850443 0.998727146493867 0.997723657451287 0.999364430275444 52 5) Not assoc w R New NotAwR yes 5 +Capreomycin rrs n.897C>G rrs_n.897C>G 1 non_coding_transcript_exon_variant 1472742 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1440 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 965 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 27 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.897C>T rrs_n.897C>T 1 non_coding_transcript_exon_variant 1472742 1 0 0 0 0 17 2049 15466 0 0 0.00179871197794837 0.998902021572046 0.99824261031775 0.999360261118369 0 0 0.195064322969093 NA NA NA 0 0 0.195064322969093 NA NA NA NA 1080 2386 False False 0 0 1.830868357271 0 0 0.00179871197794837 0.998902021572046 0.99824261031775 0.999360261118369 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 11 1305 8631 0 0 0.00282273611850443 0.998727146493867 0.997723657451287 0.999364430275444 0 0 0.284914152918154 NA NA NA 0 0 0.284914152918154 NA NA NA NA 621 1774 False False 0 0 0 0 0 0 0 0 0 2.63876604338672 0 0 0.00282273611850443 0.998727146493867 0.997723657451287 0.999364430275444 393 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.899A>G rrs_n.899A>G 1 non_coding_transcript_exon_variant 1472744 0 0 0 0 3 29 2046 15454 0.00146412884333821 0.000302040401839334 0.00427278776332334 0.998126977975844 0.997311126912655 0.998745260027249 0.09375 0.0197671801732848 0.250226950683794 NA NA NA 0 0 0.119444869069502 NA NA NA NA 1226 2386 False False 0.781373242997269 0.152158440037585 2.52438240300731 0 0 0.00180134700867096 0.998126977975844 0.997311126912655 0.998745260027249 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 21 1303 8621 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.997570006942837 0.996287883483402 0.998495186187755 0.0869565217391304 0.0107099660378758 0.280379335909411 NA NA NA 0 0 0.161097615219079 NA NA NA NA 758 1774 False False 0 0 0 0 0 0 0 0.630120966268318 0.0715467053631534 2.58306231455256 0 0 0.00282706266083767 0.997570006942837 0.996287883483402 0.998495186187755 426 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.89A>G rrs_n.89A>G 1 non_coding_transcript_exon_variant 1471934 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 5 3) Uncertain significance No change no 1 +Capreomycin rrs n.-89T>C rrs_n.-89T>C 1 upstream_gene_variant 1471757 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.905C>A rrs_n.905C>A 1 non_coding_transcript_exon_variant 1472750 1 7 1 6 1 6 2048 15477 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999612478201898 0.999156720468893 0.999857773477374 0.142857142857142 0.00361029686190058 0.578723197043195 0.142857142857142 0.00361029686190058 0.578723197043195 0.142857142857142 0.00361029686190058 0.578723197043195 1.259521484375 0.0273691036001646 10.3895811388841 0.581113174358187 159 2386 False False 1.259521484375 0.0273691036001646 10.3895811388841 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 8 3) Uncertain significance No change no 1 +Capreomycin rrs n.905C>G rrs_n.905C>G 1 non_coding_transcript_exon_variant 1472750 1 6 0 6 0 7 2049 15476 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 6.41945279027998 1 619.5 2386 False False 0 0 5.24430081649792 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 10.0364048825129 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 8 3) Uncertain significance No change no 1 +Capreomycin rrs n.905C>T rrs_n.905C>T 1 non_coding_transcript_exon_variant 1472750 1 1 0 1 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 293.33332543886 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 622 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 3 3) Uncertain significance No change no 1 +Capreomycin rrs n.906A>G rrs_n.906A>G 1 non_coding_transcript_exon_variant 1472751 1 67 5 62 8 68 2041 15415 0.00390434358223523 0.00168707939779644 0.00767854500622988 0.995608086288187 0.994435478582681 0.99658794147145 0.105263157894736 0.0465535627574764 0.196916699191686 0.0746268656716417 0.0246747065995901 0.165626166204845 0.0684931506849315 0.0226121955029953 0.152647013777429 0.609086311264244 0.190856714546787 1.50180099980836 0.343894172503223 138 2386 False False 0.888549442314897 0.368202393858933 1.8555251044651 0.00244379276637341 0.000793954164112734 0.00569370847210442 0.995608086288187 0.994435478582681 0.99658794147145 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 32 1 31 3 33 1302 8609 0.00229885057471264 0.000474329389656033 0.00670338609202181 0.996181439481601 0.994641463239562 0.997370064788675 0.0833333333333333 0.0175264959239346 0.224689760556973 0.03125 0.000790868597952557 0.162170994181511 0.0294117647058823 0.00074436423469026 0.153267669560317 0.213294683117784 0.00523295450277832 1.28227738782421 0.114688647921003 28 1774 False False 0 0 0 0 0 0 0 0.601103197877391 0.117821988427772 1.92058203861392 0.00076745970836531 1.94302087631205e-05 0.00426851804482144 0.996181439481601 0.994641463239562 0.997370064788675 70 Not assoc w R 3) Uncertain significance DOWN from NotAwR to Uncertain yes 2 +Capreomycin rrs n.907A>T rrs_n.907A>T 1 non_coding_transcript_exon_variant 1472752 1 6 0 6 0 6 2049 15477 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 6.41986758323506 1 619.5 2386 False False 0 0 6.41986758323506 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 10.0364048825129 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 2 3) Uncertain significance No change no 1 +Capreomycin rrs n.908_909insT rrs_n.908_909insT 1 non_coding_transcript_exon_variant 1472753 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.908A>C rrs_n.908A>C 1 non_coding_transcript_exon_variant 1472753 1 23 1 22 1 24 2048 15459 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.998449912807595 0.997694465417801 0.999006585264568 0.04 0.00101219969931084 0.203516913922414 0.0434782608695652 0.0011001686304415 0.21948660745348 0.04 0.00101219969931084 0.203516913922414 0.34310635653409 0.00831277026759928 2.12505819403099 0.510224236162276 155 2386 False False 0.31451416015625 0.00764770337470687 1.93093164782037 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.998449912807595 0.997694465417801 0.999006585264568 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 1 8 1 9 1304 8633 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.998958574404073 0.998023974495813 0.999523686828456 0.1 0.00252857854446178 0.445016117028195 0.111111111111111 0.00280913674659921 0.482496514917337 0.1 0.00252857854446178 0.445016117028195 0.827549846625766 0.0186358400736451 6.18115600496688 1 503.5 1774 False False 0 0 0 0 0 0 0 0.735599863667348 0.0167698879909291 5.31583775548636 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.998958574404073 0.998023974495813 0.999523686828456 17 3) Uncertain significance No change no 1 +Capreomycin rrs n.908A>G rrs_n.908A>G 1 non_coding_transcript_exon_variant 1472753 1 5 0 5 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 8.24895966345574 1 194.5 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 35.2688392655279 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 3 3) Uncertain significance No change no 1 +Capreomycin rrs n.908A>T rrs_n.908A>T 1 non_coding_transcript_exon_variant 1472753 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.909G>T rrs_n.909G>T 1 non_coding_transcript_exon_variant 1472754 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1329 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.910G>A rrs_n.910G>A 1 non_coding_transcript_exon_variant 1472755 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1362 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 892 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 20 3) Uncertain significance No change no 1 +Capreomycin rrs n.-91C>A rrs_n.-91C>A 1 upstream_gene_variant 1471755 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.-91C>T rrs_n.-91C>T 1 upstream_gene_variant 1471755 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1425 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 952 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 1 3) Uncertain significance No change no 1 +Capreomycin rrs n.922G>A rrs_n.922G>A 1 non_coding_transcript_exon_variant 1472767 1 0 0 0 0 12 2049 15471 0 0 0.00179871197794837 0.999224956403797 0.99864654661041 0.999599461575238 0 0 0.264648469397051 NA NA NA 0 0 0.264648469397051 NA NA NA NA 1342 2386 False False 0 0 2.71972624224414 0 0 0.00179871197794837 0.999224956403797 0.99864654661041 0.999599461575238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 8 1305 8634 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 872 1774 False False 0 0 0 0 0 0 0 0 0 3.88085962593317 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 80 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.924C>T rrs_n.924C>T 1 non_coding_transcript_exon_variant 1472769 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1205 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 737 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.929C>T rrs_n.929C>T 1 non_coding_transcript_exon_variant 1472774 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.-92T>G rrs_n.-92T>G 1 upstream_gene_variant 1471754 1 4 0 4 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 11.4504880046624 1 619.5 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Capreomycin rrs n.93_94insG rrs_n.93_94insG 1 non_coding_transcript_exon_variant 1471938 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.934G>A rrs_n.934G>A 1 non_coding_transcript_exon_variant 1472779 1 0 0 0 0 7 2049 15476 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1282 2386 False False 0 0 5.24430081649792 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 1305 8637 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 813 1774 False False 0 0 0 0 0 0 0 0 0 7.23014561016525 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 12 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.935G>A rrs_n.935G>A 1 non_coding_transcript_exon_variant 1472780 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Capreomycin rrs n.936C>T rrs_n.936C>T 1 non_coding_transcript_exon_variant 1472781 NA 0 0 0 3 40 2046 15443 0.00146412884333821 0.000302040401839334 0.00427278776332334 0.997416521345992 0.99648367957731 0.998153703147083 0.0697674418604651 0.0146254969951322 0.190607231885792 NA NA NA 0 0 0.0880973028788023 NA NA NA NA 1374 2386 False True 0.566092375366568 0.111912093722137 1.7800457603314 0 0 0.00180134700867096 0.997416521345992 0.99648367957731 0.998153703147083 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 2 25 1303 8617 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.997107151122425 0.995732526440765 0.998127052681522 0.074074074074074 0.00910007294230628 0.242898346845627 NA NA NA 0 0 0.137185171530712 NA NA NA NA 905 1774 False True 0 1 1 0 0 0 0 0.52905602455871 0.0606701478824147 2.12589058262651 0 0 0.00282706266083767 0.997107151122425 0.995732526440765 0.998127052681522 515 5) Not assoc w R New NotAwR yes 5 +Capreomycin rrs n.-93C>T rrs_n.-93C>T 1 upstream_gene_variant 1471753 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Capreomycin rrs n.93T>A rrs_n.93T>A 1 non_coding_transcript_exon_variant 1471938 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1128 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 668 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.941C>T rrs_n.941C>T 1 non_coding_transcript_exon_variant 1472786 1 0 0 0 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1399 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 928 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 11 3) Uncertain significance No change no 1 +Capreomycin rrs n.945T>C rrs_n.945T>C 1 non_coding_transcript_exon_variant 1472790 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1295 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 827 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 86 3) Uncertain significance No change no 1 +Capreomycin rrs n.948A>C rrs_n.948A>C 1 non_coding_transcript_exon_variant 1472793 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1140 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 678 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.948A>T rrs_n.948A>T 1 non_coding_transcript_exon_variant 1472793 0 0 0 0 3 39 2046 15444 0.00146412884333821 0.000302040401839334 0.00427278776332334 0.997481108312342 0.996558184350982 0.998208227364072 0.0714285714285714 0.01497969167071 0.194831198156491 NA NA NA 0 0 0.0902511009603342 NA NA NA NA 1149 2386 False True 0.580645161290322 0.114666331318419 1.82922633795774 0 0 0.00180134700867096 0.997481108312342 0.996558184350982 0.998208227364072 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 2 24 1303 8618 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.997222865077528 0.995870643521197 0.998219851703105 0.0769230769230769 0.00945539100371274 0.251302916695373 NA NA NA 0 0 0.142473597722525 NA NA NA NA 685 1774 False True 0 1 1 0 0 0 0 0.551163980557687 0.0630636114266055 2.22446397546412 0 0 0.00282706266083767 0.997222865077528 0.995870643521197 0.998219851703105 502 5) Not assoc w R New NotAwR yes 5 +Capreomycin rrs n.958T>A rrs_n.958T>A 1 non_coding_transcript_exon_variant 1472803 2 1 0 1 3 33 2046 15450 0.00146412884333821 0.000302040401839334 0.00427278776332334 0.997868630110443 0.997008054406869 0.998532422825367 0.0833333333333333 0.0175264959239346 0.224689760556973 0 0 0.975 0 0 0.105762810074579 0 0 293.175947253091 1 619.5 2386 False False 0.686483604372167 0.134591373632332 2.19150852495999 0 0 0.00180134700867096 0.997868630110443 0.997008054406869 0.998532422825367 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 22 1303 8620 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.997454292987734 0.996148291078399 0.99840395257875 0.0833333333333333 0.0102563412812501 0.269972801557603 NA NA NA 0 0 0.154372512815574 NA NA NA NA 738 1774 False False 0 0 0 0 0 0 0 0.601409335100816 0.0684769098444326 2.45137898894346 0 0 0.00282706266083767 0.997454292987734 0.996148291078399 0.99840395257875 474 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.958T>C rrs_n.958T>C 1 non_coding_transcript_exon_variant 1472803 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1164 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 698 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 4 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.970A>C rrs_n.970A>C 1 non_coding_transcript_exon_variant 1472815 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance No change no 1 +Capreomycin rrs n.972C>T rrs_n.972C>T 1 non_coding_transcript_exon_variant 1472817 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin rrs n.979T>A rrs_n.979T>A 1 non_coding_transcript_exon_variant 1472824 1 0 0 0 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1240 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 772 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 26 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.980G>A rrs_n.980G>A 1 non_coding_transcript_exon_variant 1472825 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1400 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 929 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 25 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.981G>A rrs_n.981G>A 1 non_coding_transcript_exon_variant 1472826 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1306 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.982G>T rrs_n.982G>T 1 non_coding_transcript_exon_variant 1472827 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1165 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 699 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.983T>C rrs_n.983T>C 1 non_coding_transcript_exon_variant 1472828 NA 0 0 0 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1150 2386 False True 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 686 1774 False True 1 0 1 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 41 5) Not assoc w R New NotAwR yes 5 +Capreomycin rrs n.98T>C rrs_n.98T>C 1 non_coding_transcript_exon_variant 1471943 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1343 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 873 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.991_992delGCinsCCTTTG rrs_n.991_992delGCinsCCTTTG 1 non_coding_transcript_exon_variant 1472836 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1216 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.991_996delGCACAGinsCCTCT rrs_n.991_996delGCACAGinsCCTCT 1 non_coding_transcript_exon_variant 1472836 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1283 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 814 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.995A>C rrs_n.995A>C 1 non_coding_transcript_exon_variant 1472840 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1401 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 930 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.996_1002delGGACGCGinsAC rrs_n.996_1002delGGACGCGinsAC 1 non_coding_transcript_exon_variant 1472841 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1098 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.996_1003delGGACGCGTinsACC rrs_n.996_1003delGGACGCGTinsACC 1 non_coding_transcript_exon_variant 1472841 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1441 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.999C>A rrs_n.999C>A 1 non_coding_transcript_exon_variant 1472844 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1375 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 906 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin rrs n.9G>A rrs_n.9G>A 1 non_coding_transcript_exon_variant 1471854 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin Rv2680 c.-101_-51delTGACCTCCGCCGGCGACGATGCAGAGCGCAGCGATGAGGAGGAGCGGCGCT Rv2680_c.-101_-51delTGACCTCCGCCGGCGACGATGCAGAGCGCAGCGATGAGGAGGAGCGGCGCT 2 upstream_gene_variant 2996003 1 18 0 18 0 28 2049 15455 0 0 0.00179871197794837 0.998191564942194 0.997387360340353 0.998797982072775 0 0 0.123436118500263 0 0 0.185301968137852 0 0 0.123436118500263 0 0 1.71716215316158 0.257537755207454 135 2386 False False 0 0 1.06319707539763 0 0 0.00179871197794837 0.998191564942194 0.997387360340353 0.998797982072775 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 0 14 1305 8628 0 0 0.00282273611850443 0.998380004628558 0.99728341538717 0.999114059339894 0 0 0.231635761650116 0 0 0.369416647552819 0 0 0.231635761650116 0 0 3.87816292608386 0.60770248013084 113 1774 False False 0 0 0 0 0 0 0 0 0 1.99604026463537 0 0 0.00282273611850443 0.998380004628558 0.99728341538717 0.999114059339894 70 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2680 c.108C>T Rv2680_c.108C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2680 c.-120G>A Rv2680_c.-120G>A 2 upstream_gene_variant 2995985 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2380 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2680 c.-122T>C Rv2680_c.-122T>C 2 upstream_gene_variant 2995983 1 2 0 2 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 40.2315677803598 1 619.5 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1764 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 4 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2680 c.129A>G Rv2680_c.129A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 2048 15481 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999870826067299 0.999533458063883 0.999984356054634 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.779541015625 0.0640320806562028 72.4657839845296 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2680 c.-133G>A Rv2680_c.-133G>A 2 upstream_gene_variant 2995972 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2680 c.147G>A Rv2680_c.147G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2680 c.150G>A Rv2680_c.150G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2680 c.177G>T Rv2680_c.177G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2680 c.183A>G Rv2680_c.183A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 18.2980327465689 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2680 c.201C>G Rv2680_c.201C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2680 c.207C>T Rv2680_c.207C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2680 c.-20G>A Rv2680_c.-20G>A 2 upstream_gene_variant 2996085 1 6 0 6 1 9 2048 15474 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999418717302848 0.998896832459985 0.999734167184357 0.1 0.00252857854446178 0.445016117028195 0 0 0.4592581264399 0 0 0.336267116879942 0 0 6.42175943345481 1 619.5 2386 False False 0.839518229166666 0.0191442481599193 6.06407759157277 0 0 0.00179958946453767 0.999418717302848 0.998896832459985 0.999734167184357 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 1 6 1304 8636 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999305716269382 0.998489453757575 0.999745168847445 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.602364635616474 0 0 0.4592581264399 0 0 10.0417817562114 1 503.5 1774 False False 0 0 0 0 0 0 0 1.10378323108384 0.0239783465953148 9.10896322125085 0 0 0.00282489773306727 0.999305716269382 0.998489453757575 0.999745168847445 404 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2680 c.-21A>C Rv2680_c.-21A>C 2 upstream_gene_variant 2996084 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2680 c.225T>C Rv2680_c.225T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2680 c.240C>A Rv2680_c.240C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 40.2367591624089 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2680 c.267C>T Rv2680_c.267C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 40.2367591624089 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2680 c.282T>C Rv2680_c.282T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2680 c.306G>A Rv2680_c.306G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2680 c.321G>A Rv2680_c.321G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2680 c.336G>A Rv2680_c.336G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2680 c.342A>G Rv2680_c.342A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2680 c.384G>C Rv2680_c.384G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 40.2367591624089 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2680 c.396G>A Rv2680_c.396G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 40.2367591624089 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2680 c.405C>T Rv2680_c.405C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2680 c.450A>G Rv2680_c.450A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2680 c.474C>A Rv2680_c.474C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2680 c.483G>A Rv2680_c.483G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 40.2367591624089 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2680 c.498G>A Rv2680_c.498G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2680 c.51C>T Rv2680_c.51C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2680 c.543C>T Rv2680_c.543C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 2049 15477 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 6.41986758323506 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 6 1305 8636 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 5.62683462374212 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2680 c.549C>A Rv2680_c.549C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2680 c.570G>A Rv2680_c.570G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 40.2367591624089 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2680 c.619C>A Rv2680_c.619C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2680 c.-71G>A Rv2680_c.-71G>A 2 upstream_gene_variant 2996034 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 121 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2680 c.-79A>C Rv2680_c.-79A>C 2 upstream_gene_variant 2996026 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2378 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1769 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 17 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2680 c.87A>T Rv2680_c.87A>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2680 c.-93G>A Rv2680_c.-93G>A 2 upstream_gene_variant 2996012 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2680 c.-95C>A Rv2680_c.-95C>A 2 upstream_gene_variant 2996010 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2374 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1766 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 7 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2680 c.-96T>C Rv2680_c.-96T>C 2 upstream_gene_variant 2996009 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2377 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1768 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 7 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2680 c.-99A>C Rv2680_c.-99A>C 2 upstream_gene_variant 2996006 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2386 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1774 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2680 LoF Rv2680_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2680 p.Ala104Thr Rv2680_p.Ala104Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 7 2049 15476 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 0 0 0.409616397225003 0 0 0.521823750104981 0 0 0.409616397225003 0 0 8.24789386425432 1 619.5 2386 False False 0 0 5.24430081649792 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 7 1305 8635 0 0 0.00282273611850443 0.999190002314279 0.998331811834773 0.999674278877205 0 0 0.409616397225003 0 0 0.521823750104981 0 0 0.409616397225003 0 0 7.22847167093785 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 4.59639609856608 0 0 0.00282273611850443 0.999190002314279 0.998331811834773 0.999674278877205 6 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2680 p.Ala131Thr Rv2680_p.Ala131Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 2049 15477 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 6.41986758323506 1 619.5 2386 False False 0 0 6.41986758323506 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 10.0364048825129 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 1 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2680 p.Ala170Val Rv2680_p.Ala170Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2680 p.Ala181Ser Rv2680_p.Ala181Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 2048 15482 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.99993541303365 0.999640197578315 0.999998364800924 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 293.494766828651 1 194.5 2386 False False 7.5595703125 0.096257452000026 590.418198079286 0 0 0.00179958946453767 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 1304 8641 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999884286044897 0.999355453609522 0.999997070380594 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 257.429115860043 1 503.5 1774 False False 0 0 0 0 0 0 0 6.62653374233128 0.0843535983905244 517.917818294861 0 0 0.00282489773306727 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2680 p.Ala35Asp Rv2680_p.Ala35Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 15 0 15 1 20 2048 15463 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.998708260672996 0.998005714908558 0.999210799130878 0.0476190476190476 0.00120488344836351 0.238159909936821 0 0 0.218019360910534 0 0 0.168433470983085 0 0 2.10704480662813 0.243580237646102 128 2386 False False 0.3775146484375 0.00910695565376336 2.36294053215344 0 0 0.00179958946453767 0.998708260672996 0.998005714908558 0.999210799130878 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 14 0 14 0 18 1305 8624 0 0 0.00282273611850443 0.997917148808146 0.996710187129532 0.998765117784843 0 0 0.185301968137852 0 0 0.231635761650116 0 0 0.185301968137852 0 0 1.99511492862654 0.239835092853786 87 1774 False False 0 0 0 0 0 0 0 0 0 1.50540367026396 0 0 0.00282273611850443 0.997917148808146 0.996710187129532 0.998765117784843 488 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2680 p.Ala59Thr Rv2680_p.Ala59Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2376 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2680 p.Arg10Gly Rv2680_p.Arg10Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2379 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1770 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2680 p.Arg10His Rv2680_p.Arg10His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2680 p.Asp12Asn Rv2680_p.Asp12Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2384 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2680 p.Asp156Asn Rv2680_p.Asp156Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2382 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1772 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2680 p.Asp203Ala Rv2680_p.Asp203Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2680 p.Asp89Asn Rv2680_p.Asp89Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 18.2980327465689 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 35.2688392655279 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2680 p.Gln184Glu Rv2680_p.Gln184Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2680 p.Glu122Gln Rv2680_p.Glu122Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2680 p.Glu167Gly Rv2680_p.Glu167Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2375 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1767 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2680 p.Glu43Ala Rv2680_p.Glu43Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2680 p.Glu74Asp Rv2680_p.Glu74Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2680 p.Gly61Glu Rv2680_p.Gly61Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 40.2341634723554 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 35.2688392655279 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2680 p.His66Arg Rv2680_p.His66Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2680 p.Ile42fs Rv2680_p.Ile42fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2680 p.Ile47Thr Rv2680_p.Ile47Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2680 p.Ile47Val Rv2680_p.Ile47Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 0 9 2049 15474 0 0 0.00179871197794837 0.999418717302848 0.998896832459985 0.999734167184357 0 0 0.336267116879942 0 0 0.369416647552819 0 0 0.336267116879942 0 0 4.42766068883569 0.608192770563446 164.5 2386 False False 0 0 3.82923083971975 0 0 0.00179871197794837 0.999418717302848 0.998896832459985 0.999734167184357 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2680 p.Ile64Thr Rv2680_p.Ile64Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2680 p.Ile72Thr Rv2680_p.Ile72Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2385 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2680 p.Leu110Val Rv2680_p.Leu110Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2680 p.Pro50Arg Rv2680_p.Pro50Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2680 p.Pro67Arg Rv2680_p.Pro67Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2383 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1773 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2680 p.Ser76Cys Rv2680_p.Ser76Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2680 p.Ser93Phe Rv2680_p.Ser93Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2371 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2680 p.Thr173Ala Rv2680_p.Thr173Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2373 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1765 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2680 p.Thr176fs Rv2680_p.Thr176fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2680 p.Thr176Ile Rv2680_p.Thr176Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 0 0 0.841886116991581 0 0 0.521823750104981 0 0 40.2289720864225 1 619.5 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1771 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2680 p.Thr202Ile Rv2680_p.Thr202Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2381 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2680 p.Val139Met Rv2680_p.Val139Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 35.2688392655279 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 2 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2680 p.Val183Phe Rv2680_p.Val183Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 22 1 21 2 27 2047 15456 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.998256151908544 0.997463799190087 0.998850488356206 0.0689655172413793 0.00846396225300182 0.227661889944486 0.0454545454545454 0.00115014752657357 0.228444397667633 0.0357142857142857 0.000903798755658059 0.183477597544623 0.359550561797752 0.00869323308444387 2.23810405746835 0.505209027431809 154 2386 False False 0.559300873907615 0.064406722000658 2.22851533624212 0.00048828125 1.23621345180143e-05 0.00271749449396634 0.998256151908544 0.997463799190087 0.998850488356206 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 21 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2680 p.Val30Ala Rv2680_p.Val30Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2372 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 c.1002G>A Rv2681_c.1002G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 11.4504880046624 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 16.0319456706962 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2681 c.1017G>C Rv2681_c.1017G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 40.2367591624089 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2681 c.1158G>A Rv2681_c.1158G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2681 c.1161C>T Rv2681_c.1161C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2681 c.1167G>A Rv2681_c.1167G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 40.2367591624089 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2681 c.1170G>A Rv2681_c.1170G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 40.2367591624089 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2681 c.1185G>T Rv2681_c.1185G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 40.2367591624089 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 35.2688392655279 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2681 c.1188T>C Rv2681_c.1188T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2681 c.1206C>T Rv2681_c.1206C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 24 2049 15459 0 0 0.00179871197794837 0.998449912807595 0.997694465417801 0.999006585264568 0 0 0.142473597722525 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.25473260291809 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.0364048825129 NA NA NA NA NA NA 55 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2681 c.1212C>T Rv2681_c.1212C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 7 2049 15476 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.24430081649792 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 35.2688392655279 NA NA NA NA NA NA 26 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2681 c.1258C>T Rv2681_c.1258C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 18.2980327465689 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 16.0319456706962 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2681 c.1284G>A Rv2681_c.1284G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 40.2367591624089 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 35.2688392655279 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2681 c.1308T>C Rv2681_c.1308T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 2049 15477 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 6.41986758323506 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 16.0319456706962 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2681 c.136C>T Rv2681_c.136C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2681 c.138A>C Rv2681_c.138A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 70 2048 15413 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.995478912355486 0.994291281776584 0.996473945416664 0.0140845070422535 0.000356525274603389 0.0759934161211035 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.107512555803571 0.00268660847195613 0.619762173495384 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 1 55 1304 8587 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.993635732469335 0.991723989468447 0.995202069437412 0.0178571428571428 0.000452001530520825 0.0955259026323396 NA NA NA NA NA NA NA NA NA NA NA NA False True 1 1 1 0 0 0 0 0.119729503625209 0.00297932621201875 0.696872958434616 NA NA NA NA NA NA 114 5) Not assoc w R Now listed Silent mutation no 0 +Capreomycin Rv2681 c.174C>T Rv2681_c.174C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 5 388 2044 15095 0.00244021473889702 0.000792791037816739 0.00568538572188254 0.974940257056126 0.972354845902925 0.977345051781799 0.0127226463104325 0.004143565259526 0.0294392230904202 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.0951679040490649 0.0306828428739795 0.224428081009544 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 0 85 1305 8557 0 0 0.00282273611850443 0.990164313816246 0.987852190657013 0.992136259533344 0 0 0.0424703399112491 NA NA NA NA NA NA NA NA NA NA NA NA False True 1 1 1 0 0 0 0 0 0 0.291325902309278 NA NA NA NA NA NA 735 5) Not assoc w R Now listed Silent mutation no 0 +Capreomycin Rv2681 c.201C>A Rv2681_c.201C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 2048 15482 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.99993541303365 0.999640197578315 0.999998364800924 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 7.5595703125 0.096257452000026 590.418198079286 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2681 c.237G>A Rv2681_c.237G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 40.2367591624089 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA 16 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2681 c.264C>T Rv2681_c.264C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2681 c.297G>A Rv2681_c.297G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2681 c.321C>A Rv2681_c.321C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2681 c.33T>G Rv2681_c.33T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 40.2367591624089 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2681 c.372G>A Rv2681_c.372G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2681 c.384A>G Rv2681_c.384A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2681 c.462G>A Rv2681_c.462G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 40.2367591624089 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 35.2688392655279 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2681 c.471T>G Rv2681_c.471T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.193753017505121 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2681 c.474A>C Rv2681_c.474A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2681 c.483G>A Rv2681_c.483G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2681 c.486C>T Rv2681_c.486C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.24895966345574 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA 22 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2681 c.549G>T Rv2681_c.549G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2681 c.555G>A Rv2681_c.555G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2681 c.561G>A Rv2681_c.561G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2681 c.603G>A Rv2681_c.603G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2681 c.612A>G Rv2681_c.612A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2681 c.67T>C Rv2681_c.67T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.24895966345574 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.0364048825129 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2681 c.688C>A Rv2681_c.688C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2681 c.714G>A Rv2681_c.714G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2681 c.717T>C Rv2681_c.717T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2681 c.72C>A Rv2681_c.72C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2681 c.78C>G Rv2681_c.78C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2681 c.834C>G Rv2681_c.834C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2681 c.837T>C Rv2681_c.837T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 2047 15483 0.000976085895558809 0.000118230396782607 0.00352146535805941 1 0.999761774846946 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.41952099860885 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 1303 8642 0.00153256704980842 0.000185654897205815 0.00552508794778556 1 0.999573236258028 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.24419098853007 Inf NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2681 c.924G>A Rv2681_c.924G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2681 c.99G>A Rv2681_c.99G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 40.2367591624089 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 35.2688392655279 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin Rv2681 LoF Rv2681_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 7 0 7 0 9 2049 15474 0 0 0.00179871197794837 0.999418717302848 0.998896832459985 0.999734167184357 0 0 0.336267116879942 0 0 0.409616397225003 0 0 0.336267116879942 0 0 5.24362312096424 1 194.5 2386 False False 0 0 3.82923083971975 0 0 0.00179871197794837 0.999418717302848 0.998896832459985 0.999734167184357 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 35.2688392655279 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Ala115Thr Rv2681_p.Ala115Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Ala123Thr Rv2681_p.Ala123Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Ala138Val Rv2681_p.Ala138Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Ala196Val Rv2681_p.Ala196Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 13 2049 15470 0 0 0.00179871197794837 0.999160369437447 0.998564634148971 0.999552858749588 0 0 0.24705263800047 0 0 0.409616397225003 0 0 0.24705263800047 0 0 5.24226773005977 1 619.5 2386 False False 0 0 2.47945785793639 0 0 0.00179871197794837 0.999160369437447 0.998564634148971 0.999552858749588 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 10 1305 8632 0 0 0.00282273611850443 0.99884286044897 0.997873012135272 0.999444971558315 0 0 0.30849710781876 0 0 0.521823750104981 0 0 0.30849710781876 0 0 7.22596076210892 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 2.9548002607889 0 0 0.00282273611850443 0.99884286044897 0.997873012135272 0.999444971558315 227 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Ala210Thr Rv2681_p.Ala210Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1617 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1082 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Ala269Glu Rv2681_p.Ala269Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1616 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1081 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 5 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Ala27Ser Rv2681_p.Ala27Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Ala308Thr Rv2681_p.Ala308Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Ala317Thr Rv2681_p.Ala317Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 12 0 12 0 12 2049 15471 0 0 0.00179871197794837 0.999224956403797 0.99864654661041 0.999599461575238 0 0 0.264648469397051 0 0 0.264648469397051 0 0 0.264648469397051 0 0 2.71972624224414 0.382293380068694 141 2386 False False 0 0 2.71972624224414 0 0 0.00179871197794837 0.999224956403797 0.99864654661041 0.999599461575238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 1305 8637 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 7.23014561016525 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 7.23014561016525 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 38 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Ala331fs Rv2681_p.Ala331fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Ala331Val Rv2681_p.Ala331Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Ala347Thr Rv2681_p.Ala347Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 6 2049 15477 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 0 0 0.4592581264399 0 0 0.602364635616474 0 0 0.4592581264399 0 0 11.4490087322799 1 619.5 2386 False False 0 0 6.41986758323506 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Ala354Pro Rv2681_p.Ala354Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Ala354Thr Rv2681_p.Ala354Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Ala427fs Rv2681_p.Ala427fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 293.314465539138 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Ala430Thr Rv2681_p.Ala430Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 35.2688392655279 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 2 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Ala58Thr Rv2681_p.Ala58Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1611 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1079 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Ala78Val Rv2681_p.Ala78Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Arg146Gln Rv2681_p.Arg146Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Arg173His Rv2681_p.Arg173His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1613 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Arg194Cys Rv2681_p.Arg194Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Arg233Pro Rv2681_p.Arg233Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 1 3 3 9 2046 15474 0.00146412884333821 0.000302040401839334 0.00427278776332334 0.999418717302848 0.998896832459985 0.999734167184357 0.25 0.0548606445279927 0.571858461878189 0.25 0.00630946320970987 0.805879550316756 0.1 0.00252857854446178 0.445016117028195 2.52101661779081 0.0479985435896228 31.3978078718543 0.391592606899279 143 2386 False False 2.52101661779081 0.438613660248458 10.1118325034892 0.000488519785051294 1.23681736279651e-05 0.00271882056160135 0.999418717302848 0.998896832459985 0.999734167184357 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 1 3 3 9 1302 8633 0.00229885057471264 0.000474329389656033 0.00670338609202181 0.998958574404073 0.998023974495813 0.999523686828456 0.25 0.0548606445279927 0.571858461878189 0.25 0.00630946320970987 0.805879550316756 0.1 0.00252857854446178 0.445016117028195 2.21018945212493 0.0420689736396127 27.5493339970946 0.430045476100312 102 1774 False False 0 0 0 0 0 0 0 2.21018945212493 0.384340065003022 8.86942448063952 0.00076745970836531 1.94302087631205e-05 0.00426851804482144 0.998958574404073 0.998023974495813 0.999523686828456 7 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Arg246Trp Rv2681_p.Arg246Trp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1603 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1073 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Arg271His Rv2681_p.Arg271His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Arg339Leu Rv2681_p.Arg339Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Arg339Trp Rv2681_p.Arg339Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Arg380Trp Rv2681_p.Arg380Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1587 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Arg404Cys Rv2681_p.Arg404Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1604 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Arg409Leu Rv2681_p.Arg409Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1607 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1076 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Arg51Cys Rv2681_p.Arg51Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1608 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1077 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Asp134Ala Rv2681_p.Asp134Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Asp169Glu Rv2681_p.Asp169Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Asp186Asn Rv2681_p.Asp186Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1588 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1062 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Asp260Gly Rv2681_p.Asp260Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 18.2980327465689 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Asp267Gly Rv2681_p.Asp267Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 7 19 2042 15464 0.00341630063445583 0.00137459927358868 0.00702614099723331 0.998772847639346 0.998084309989574 0.999261017508711 0.269230769230769 0.115732213291504 0.477874789693831 0 0 0.975 0 0 0.176466911806965 0 0 294.012542229993 1 619.5 2386 False False 2.79004072374864 0.989799390666383 6.94175523171288 0 0 0.00180487241597748 0.998772847639346 0.998084309989574 0.999261017508711 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1063 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 11 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Asp267Tyr Rv2681_p.Asp267Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 40.2341634723554 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 257.202999238191 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Asp32Asn Rv2681_p.Asp32Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1590 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1065 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Asp32Glu Rv2681_p.Asp32Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 293.33332543886 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Asp376fs Rv2681_p.Asp376fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Asp387Glu Rv2681_p.Asp387Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1591 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Asp394His Rv2681_p.Asp394His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 2048 15482 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.99993541303365 0.999640197578315 0.999998364800924 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1582 2386 False False 7.5595703125 0.096257452000026 590.418198079286 0 0 0.00179958946453767 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1060 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Asp48Ala Rv2681_p.Asp48Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1597 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Cys2Gly Rv2681_p.Cys2Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1605 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1074 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 1 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Cys382Phe Rv2681_p.Cys382Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1609 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Gln212Glu Rv2681_p.Gln212Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1579 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1059 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Gln264Arg Rv2681_p.Gln264Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1592 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Gln264Glu Rv2681_p.Gln264Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Glu103Ala Rv2681_p.Glu103Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Glu124Ala Rv2681_p.Glu124Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1624 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Glu12Gly Rv2681_p.Glu12Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1610 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1078 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Glu12Lys Rv2681_p.Glu12Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 293.33332543886 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 4 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Glu154Gly Rv2681_p.Glu154Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Glu326Asp Rv2681_p.Glu326Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Glu386Lys Rv2681_p.Glu386Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Glu414Gly Rv2681_p.Glu414Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Glu4Lys Rv2681_p.Glu4Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1620 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1084 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 5 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Gly239Val Rv2681_p.Gly239Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1621 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Gly28Ala Rv2681_p.Gly28Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1606 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1075 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 4 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Gly29Glu Rv2681_p.Gly29Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1618 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Gly38Asp Rv2681_p.Gly38Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Gly434Ser Rv2681_p.Gly434Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Gly81Ser Rv2681_p.Gly81Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Ile197Val Rv2681_p.Ile197Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1612 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Ile268Thr Rv2681_p.Ile268Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1598 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Ile268Val Rv2681_p.Ile268Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Ile284Ser Rv2681_p.Ile284Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Ile30Leu Rv2681_p.Ile30Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1614 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Ile40Val Rv2681_p.Ile40Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Ile73Ser Rv2681_p.Ile73Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Leu105Arg Rv2681_p.Leu105Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1595 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1069 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Leu112Pro Rv2681_p.Leu112Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Leu159Pro Rv2681_p.Leu159Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Leu180Pro Rv2681_p.Leu180Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1594 2386 False False Inf 0.193753017505121 Inf 0 0 0.00179958946453767 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1068 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0 0 0.00282489773306727 1 0.999573236258028 1 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Leu189fs Rv2681_p.Leu189fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Leu255Phe Rv2681_p.Leu255Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Leu274Val Rv2681_p.Leu274Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Leu358fs Rv2681_p.Leu358fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Leu372Pro Rv2681_p.Leu372Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Leu413Pro Rv2681_p.Leu413Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1600 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Met127Leu Rv2681_p.Met127Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1589 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1064 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Met152Ile Rv2681_p.Met152Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 18.2980327465689 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Pro287Thr Rv2681_p.Pro287Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1593 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1066 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Pro31fs Rv2681_p.Pro31fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Pro322Thr Rv2681_p.Pro322Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1615 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1080 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Pro334Thr Rv2681_p.Pro334Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 2048 15482 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.99993541303365 0.999640197578315 0.999998364800924 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 293.494766828651 1 194.5 2386 False False 7.5595703125 0.096257452000026 590.418198079286 0 0 0.00179958946453767 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Pro336Leu Rv2681_p.Pro336Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 293.33332543886 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1067 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Pro337del Rv2681_p.Pro337del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 7 0 7 0 15 2049 15468 0 0 0.00179871197794837 0.999031195504747 0.998402606935329 0.999457669301639 0 0 0.218019360910534 0 0 0.409616397225003 0 0 0.218019360910534 0 0 5.24159003468893 1 619.5 2386 False False 0 0 2.10669629306639 0 0 0.00179871197794837 0.999031195504747 0.998402606935329 0.999457669301639 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 6 1305 8636 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 0 0 0.4592581264399 0 0 0.707598226178713 0 0 0.4592581264399 0 0 16.0263801906229 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 5.62683462374212 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 45 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Pro337dup Rv2681_p.Pro337dup 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Pro375Ala Rv2681_p.Pro375Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1585 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 15 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Pro395Gln Rv2681_p.Pro395Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1584 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1061 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Pro3His Rv2681_p.Pro3His 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 40.2341634723554 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 35.2688392655279 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Ser106Gly Rv2681_p.Ser106Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1596 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1070 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 7 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Ser114Ala Rv2681_p.Ser114Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.169800530161289 Inf 0.131195335276967 59 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Ser238Ala Rv2681_p.Ser238Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1622 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Ser307Asn Rv2681_p.Ser307Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1599 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1071 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Ser374Ala Rv2681_p.Ser374Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1623 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1085 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 5 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Ser438Phe Rv2681_p.Ser438Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Ser62Leu Rv2681_p.Ser62Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1619 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1083 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Ser67Pro Rv2681_p.Ser67Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1583 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Thr207Ile Rv2681_p.Thr207Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Thr21Ile Rv2681_p.Thr21Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Thr36Pro Rv2681_p.Thr36Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1601 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Trp312Cys Rv2681_p.Trp312Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Trp340Arg Rv2681_p.Trp340Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 293.33332543886 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Tyr402* Rv2681_p.Tyr402* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Tyr66Asp Rv2681_p.Tyr66Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Tyr71His Rv2681_p.Tyr71His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Val147Ala Rv2681_p.Val147Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Val153Ile Rv2681_p.Val153Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1625 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1086 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Val243Ala Rv2681_p.Val243Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1602 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1072 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Val367Ala Rv2681_p.Val367Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1580 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Val417Ala Rv2681_p.Val417Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 2048 15482 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.99993541303365 0.999640197578315 0.999998364800924 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1586 2386 False False 7.5595703125 0.096257452000026 590.418198079286 0 0 0.00179958946453767 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin Rv2681 p.Val88Ile Rv2681_p.Val88Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1581 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin tlyA c.150C>G tlyA_c.150C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin tlyA c.165G>A tlyA_c.165G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 3 106 2046 15377 0.00146412884333821 0.000302040401839334 0.00427278776332334 0.993153781566879 0.991725640396102 0.994391572949237 0.0275229357798165 0.00571225728249574 0.0783301281121533 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.212706800199192 0.0431440654592247 0.639742024864455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 13 1305 8629 0 0 0.00282273611850443 0.998495718583661 0.997429006709305 0.999198798037271 0 0 0.24705263800047 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.17279669430301 NA NA NA NA NA NA 97 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin tlyA c.-186C>T tlyA_c.-186C>T 1 upstream_gene_variant 1917754 1 5 0 5 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 8.24895966345574 1 194.5 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 35.2688392655279 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 5 3) Uncertain significance No change no 1 +Capreomycin tlyA c.-205G>A tlyA_c.-205G>A 1 upstream_gene_variant 1917735 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin tlyA c.-213G>A tlyA_c.-213G>A 1 upstream_gene_variant 1917727 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1450 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Capreomycin tlyA c.-214C>A tlyA_c.-214C>A 1 upstream_gene_variant 1917726 1 3 0 3 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 18.2956781909983 1 619.5 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 5 1305 8637 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 16.028235350447 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 7.23014561016525 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 10 3) Uncertain significance No change no 1 +Capreomycin tlyA c.-217C>A tlyA_c.-217C>A 1 upstream_gene_variant 1917723 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin tlyA c.-220G>A tlyA_c.-220G>A 1 upstream_gene_variant 1917720 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin tlyA c.-222A>G tlyA_c.-222A>G 1 upstream_gene_variant 1917718 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin tlyA c.225G>A tlyA_c.225G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 3 2048 15480 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999806239100949 0.999433853882399 0.999960040061829 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.51953125 0.047970285762596 31.379124977949 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA 22 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin tlyA c.-22G>C tlyA_c.-22G>C 1 upstream_gene_variant 1917918 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Capreomycin tlyA c.-234C>T tlyA_c.-234C>T 1 upstream_gene_variant 1917706 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin tlyA c.246G>A tlyA_c.246G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin tlyA c.261G>A tlyA_c.261G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin tlyA c.276G>C tlyA_c.276G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 18.2980327465689 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin tlyA c.306C>T tlyA_c.306C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 40.2367591624089 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin tlyA c.318C>A tlyA_c.318C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin tlyA c.31C>T tlyA_c.31C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin tlyA c.324G>C tlyA_c.324G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin tlyA c.333C>T tlyA_c.333C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 4 1 2045 15482 0.00195217179111761 0.00053214923576723 0.00499072666314977 0.99993541303365 0.999640197578315 0.999998364800924 0.8 0.28358206388191 0.994949236620532 NA NA NA NA NA NA NA NA NA NA NA NA False False 30.282640586797 2.99371232722536 1477.82550656403 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 4 1 1301 8641 0.00306513409961685 0.000835757856895071 0.00782921001204628 0.999884286044897 0.999355453609522 0.999997070380594 0.8 0.28358206388191 0.994949236620532 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 26.5672559569561 2.62471114562733 1298.18113593707 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin tlyA c.33A>G tlyA_c.33A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2033 15393 16 90 0.992191312835529 0.987350078783211 0.995530264877585 0.00581282697151714 0.00467671412827058 0.0071401876484457 0.116664753816136 0.111934008894562 0.121523839431505 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.742910738647437 0.43246371005724 1.35789266774264 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 1298 8568 7 74 0.99463601532567 0.988979551094711 0.997840761904322 0.00856283267762092 0.00672947552776549 0.0107380814411409 0.131562943442124 0.124951920475689 0.138392276010049 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 0 1.60150726957449 0.737477268609122 4.13067263562806 NA NA NA NA NA NA 34599 5) Not assoc w R Now listed Silent mutation no 0 +Capreomycin tlyA c.345C>T tlyA_c.345C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin tlyA c.348C>G tlyA_c.348C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin tlyA c.-34G>A tlyA_c.-34G>A 1 upstream_gene_variant 1917906 1 3 0 3 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 18.2980327465689 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin tlyA c.393C>T tlyA_c.393C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin tlyA c.408A>C tlyA_c.408A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin tlyA c.423G>T tlyA_c.423G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin tlyA c.-44G>A tlyA_c.-44G>A 1 upstream_gene_variant 1917896 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Capreomycin tlyA c.453A>G tlyA_c.453A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.193753017505121 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin tlyA c.465G>A tlyA_c.465G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin tlyA c.471C>T tlyA_c.471C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin tlyA c.486C>G tlyA_c.486C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 40.2367591624089 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 35.2688392655279 NA NA NA NA NA NA 11 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin tlyA c.531C>T tlyA_c.531C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin tlyA c.540G>T tlyA_c.540G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 18.2980327465689 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 16.0319456706962 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin tlyA c.54A>G tlyA_c.54A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 40.2367591624089 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin tlyA c.552G>A tlyA_c.552G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin tlyA c.558G>A tlyA_c.558G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 6 2048 15477 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999612478201898 0.999156720468893 0.999857773477374 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.259521484375 0.0273691036001646 10.3895811388841 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 6 1305 8636 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 5.62683462374212 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin tlyA c.582C>G tlyA_c.582C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 40.2367591624089 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin tlyA c.630G>T tlyA_c.630G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin tlyA c.645A>C tlyA_c.645A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 40.2367591624089 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 35.2688392655279 NA NA NA NA NA NA 15 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin tlyA c.645A>G tlyA_c.645A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin tlyA c.732C>T tlyA_c.732C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 40.2367591624089 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin tlyA c.735G>A tlyA_c.735G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 40.2367591624089 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin tlyA c.738G>A tlyA_c.738G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 40.2367591624089 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 35.2688392655279 NA NA NA NA NA NA 16 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin tlyA c.750A>T tlyA_c.750A>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin tlyA c.84C>T tlyA_c.84C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin tlyA c.90C>T tlyA_c.90C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin tlyA LoF tlyA_LoF 1 LoF (see "Genomic_coordinates" sheet) 1 107 84 23 92 30 1957 15453 0.0448999511957052 0.0363465670388823 0.0547837641589467 0.998062391009494 0.99723508866369 0.998692333308913 0.754098360655737 0.667932921592337 0.827532983940476 0.785046728971962 0.695128253644129 0.858591211841101 0.736842105263157 0.646105915987259 0.814880910779185 28.8385505765257 17.9439344622096 48.0413717769059 7.7869245753706e-58 2 2386 True False 24.2152273888605 15.8295447874899 37.9736843863042 0.041156295933366 0.0329582688334008 0.0507029641233723 0.998062391009494 0.99723508866369 0.998692333308913 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 70 57 13 65 15 1240 8627 0.0498084291187739 0.0386482784271213 0.0630474882257985 0.998264290673455 0.997138824765365 0.999028221442365 0.8125 0.709672104352308 0.89108631185247 0.814285714285714 0.703385249814952 0.897238918298297 0.791666666666666 0.679770488870628 0.878448797092191 30.5049007444168 16.4281018876857 60.8727579115519 1.1336216202954e-38 2 1774 True False 0 0 0 0 0 0 0 30.1481182795698 16.9316567781623 57.08637410776 0.0439475713184271 0.0334525440730227 0.0565669497698598 0.998264290673455 0.997138824765365 0.999028221442365 NA 1) Assoc w R UP from AwRI to AwR yes 4 +Capreomycin tlyA p.Ala105fs tlyA_p.Ala105fs 1 frameshift (see "Genomic_coordinates" sheet) 1 5 4 1 4 1 2045 15482 0.00195217179111761 0.00053214923576723 0.00499072666314977 0.99993541303365 0.999640197578315 0.999998364800924 0.8 0.28358206388191 0.994949236620532 0.8 0.28358206388191 0.994949236620532 0.8 0.28358206388191 0.994949236620532 30.282640586797 2.99371232722536 1477.82550656403 0.000843595724640718 13 2386 False False 30.282640586797 2.99371232722536 1477.82550656403 0.00195217179111761 0.00053214923576723 0.00499072666314977 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 3 0 3 0 1302 8642 0.00229885057471264 0.000474329389656033 0.00670338609202181 1 0.999573236258028 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 2.73902522369248 Inf 0.00225365357559397 12 1774 False False 0 0 0 0 0 0 0 Inf 2.73902522369248 Inf 0.00229885057471264 0.000474329389656033 0.00670338609202181 1 0.999573236258028 1 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Ala106fs tlyA_p.Ala106fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.169800530161289 Inf 0.131195335276967 59 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Ala110fs tlyA_p.Ala110fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1454 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Ala111fs tlyA_p.Ala111fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.169800530161289 Inf 0.131195335276967 59 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Ala166Val tlyA_p.Ala166Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Capreomycin tlyA p.Ala205fs tlyA_p.Ala205fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 2047 15483 0.000976085895558809 0.000118230396782607 0.00352146535805941 1 0.999761774846946 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 1.41952099860885 Inf 0.01365317821084 25.5 2386 False False Inf 1.41952099860885 Inf 0.000976085895558809 0.000118230396782607 0.00352146535805941 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 1303 8642 0.00153256704980842 0.000185654897205815 0.00552508794778556 1 0.999573236258028 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 1.24419098853007 Inf 0.0172007558014444 21.5 1774 False False 0 0 0 0 0 0 0 Inf 1.24419098853007 Inf 0.00153256704980842 0.000185654897205815 0.00552508794778556 1 0.999573236258028 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Ala210Thr tlyA_p.Ala210Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1451 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 971 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin tlyA p.Ala212Val tlyA_p.Ala212Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1445 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin tlyA p.Ala215fs tlyA_p.Ala215fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 2048 15482 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.99993541303365 0.999640197578315 0.999998364800924 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 7.5595703125 0.096257452000026 590.418198079286 0.220090832740563 119.5 2386 False False 7.5595703125 0.096257452000026 590.418198079286 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Ala250Thr tlyA_p.Ala250Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Capreomycin tlyA p.Ala259Thr tlyA_p.Ala259Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 18.2980327465689 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 16.0319456706962 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 NA 3) Uncertain significance No change no 1 +Capreomycin tlyA p.Ala29Val tlyA_p.Ala29Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 40.2315677803598 1 619.5 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 35.2647591017504 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 1 3) Uncertain significance No change no 1 +Capreomycin tlyA p.Ala43fs tlyA_p.Ala43fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 35.2688392655279 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Ala51Val tlyA_p.Ala51Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin tlyA p.Ala5Thr tlyA_p.Ala5Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin tlyA p.Ala5Val tlyA_p.Ala5Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Capreomycin tlyA p.Ala67Glu tlyA_p.Ala67Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 2047 15483 0.000976085895558809 0.000118230396782607 0.00352146535805941 1 0.999761774846946 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.193847623510372 Inf 0.116821630254976 39 2386 False False Inf 1.41952099860885 Inf 0.00048828125 1.23621345180143e-05 0.00271749449396634 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 1303 8642 0.00153256704980842 0.000185654897205815 0.00552508794778556 1 0.999573236258028 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.169930745364978 Inf 0.131107983108787 31 1774 False False 0 0 0 0 0 0 0 Inf 1.24419098853007 Inf 0.000766871165644171 1.94153084409271e-05 0.00426525037799214 1 0.999573236258028 1 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin tlyA p.Ala76fs tlyA_p.Ala76fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Arg123Pro tlyA_p.Arg123Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.169800530161289 Inf 0.131195335276967 59 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 NA 3) Uncertain significance No change no 1 +Capreomycin tlyA p.Arg133fs tlyA_p.Arg133fs 1 frameshift (see "Genomic_coordinates" sheet) 1 11 9 2 11 2 2038 15481 0.00536847242557345 0.00268287699664284 0.0095853329613208 0.999870826067299 0.999533458063883 0.999984356054634 0.846153846153846 0.545528944323442 0.980793328017471 0.818181818181818 0.482244147639827 0.97716880170004 0.818181818181818 0.482244147639827 0.97716880170004 34.1827772325809 7.0660092881009 324.808528600495 1.75241900566847e-07 8 2386 True False 41.7789499509322 9.10549447400553 387.783520263117 0.00439667806546165 0.00201235220346398 0.0083297874233843 0.999870826067299 0.999533458063883 0.999984356054634 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 5 5 0 7 0 1298 8642 0.0053639846743295 0.00215923809567721 0.0110204489052888 1 0.999573236258028 1 1 0.590383602774996 1 1 0.478176249895018 1 1 0.478176249895018 1 Inf 6.09071801340688 Inf 3.83528838118074e-05 6 1774 True False 0 0 0 0 0 0 0 Inf 9.57786468233186 Inf 0.00383729854182655 0.00124709844261507 0.00893207968474829 1 0.999573236258028 1 5 1) Assoc w R UP from AwRI to AwR yes 4 +Capreomycin tlyA p.Arg133Leu tlyA_p.Arg133Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.169800530161289 Inf 0.131195335276967 59 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin tlyA p.Arg14Trp tlyA_p.Arg14Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.169800530161289 Inf 0.131195335276967 59 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin tlyA p.Arg18* tlyA_p.Arg18* 1 stop_gained (see "Genomic_coordinates" sheet) 1 3 2 1 2 2 2047 15481 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.999870826067299 0.999533458063883 0.999984356054634 0.5 0.067585986488543 0.932414013511457 0.666666666666666 0.0942993240502461 0.991596241340387 0.5 0.067585986488543 0.932414013511457 15.1255495847581 0.786856072406882 886.804284925576 0.0377750646460007 31 2386 False False 7.56277479237909 0.547801158574908 104.389914324374 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 2 1304 8640 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999768572089794 0.999164255486522 0.999971971777513 0.333333333333333 0.00840375865961264 0.905700675949754 0.5 0.012579117093425 0.987420882906574 0.333333333333333 0.00840375865961264 0.905700675949754 6.62576687116564 0.0843438363724759 517.858172025549 0.245212837103162 97 1774 False False 0 0 0 0 0 0 0 3.31288343558282 0.056110603773561 63.7302235362974 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999768572089794 0.999164255486522 0.999971971777513 1 Assoc w R Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Arg20Leu tlyA_p.Arg20Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 11.4504880046624 1 619.5 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 10.0364048825129 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 2 3) Uncertain significance New Uncertain no 0 +Capreomycin tlyA p.Arg213fs tlyA_p.Arg213fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.169800530161289 Inf 0.131195335276967 59 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 5 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Arg244His tlyA_p.Arg244His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin tlyA p.Arg244Pro tlyA_p.Arg244Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin tlyA p.Arg249Gln tlyA_p.Arg249Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin tlyA p.Arg262Cys tlyA_p.Arg262Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin tlyA p.Arg3Pro tlyA_p.Arg3Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin tlyA p.Arg3* tlyA_p.Arg3* 1 stop_gained (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 2047 15483 0.000976085895558809 0.000118230396782607 0.00352146535805941 1 0.999761774846946 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 1.41952099860885 Inf 0.01365317821084 25.5 2386 False False Inf 1.41952099860885 Inf 0.000976085895558809 0.000118230396782607 0.00352146535805941 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.169800530161289 Inf 0.131195335276967 59 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 Assoc w R Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Arg60fs tlyA_p.Arg60fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1458 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Arg65Cys tlyA_p.Arg65Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1457 2386 False False Inf 0.193753017505121 Inf 0 0 0.00179958946453767 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 977 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0 0 0.00282489773306727 1 0.999573236258028 1 1 3) Uncertain significance New Uncertain no 0 +Capreomycin tlyA p.Arg6fs tlyA_p.Arg6fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.169800530161289 Inf 0.131195335276967 59 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Arg84Gly tlyA_p.Arg84Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 28 3) Uncertain significance New Uncertain no 0 +Capreomycin tlyA p.Asn236Asp tlyA_p.Asn236Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.169800530161289 Inf 0.131195335276967 59 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 2 3) Uncertain significance New Uncertain no 0 +Capreomycin tlyA p.Asn236His tlyA_p.Asn236His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin tlyA p.Asn236Lys tlyA_p.Asn236Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 20 20 0 21 0 2028 15483 0.0102489019033674 0.00635511128056527 0.0156240716423959 1 0.999761774846946 1 1 0.83890238478092 1 1 0.831566529016914 1 1 0.831566529016914 1 Inf 37.6083319236475 Inf 2.06421236943126e-19 3 2386 True False Inf 39.6832824635984 Inf 0.009765625 0.00597501264624522 0.0150421017212931 1 0.999761774846946 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 19 19 0 20 0 1285 8642 0.0153256704980842 0.00938578862385971 0.0235704299467985 1 0.999573236258028 1 1 0.831566529016914 1 1 0.823533088193034 1 1 0.823533088193034 1 Inf 31.2966849014978 Inf 1.5318016746816e-17 3 1774 True False 0 0 0 0 0 0 0 Inf 33.1170398127889 Inf 0.0145705521472392 0.00879461419761244 0.0226605581171911 1 0.999573236258028 1 52 Assoc w R Assoc w R 1) Assoc w R No change yes 1 +Capreomycin tlyA p.Asp154Ala tlyA_p.Asp154Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1460 2386 False False Inf 0.193753017505121 Inf 0 0 0.00179958946453767 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Capreomycin tlyA p.Asp154Glu tlyA_p.Asp154Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.169800530161289 Inf 0.131195335276967 59 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin tlyA p.Asp154Gly tlyA_p.Asp154Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.169800530161289 Inf 0.131195335276967 59 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 3) Uncertain significance No change no 1 +Capreomycin tlyA p.Asp154Tyr tlyA_p.Asp154Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.169800530161289 Inf 0.131195335276967 59 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin tlyA p.Asp35Gly tlyA_p.Asp35Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 293.314465539138 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Capreomycin tlyA p.Asp48Asn tlyA_p.Asp48Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin tlyA p.Asp57Gly tlyA_p.Asp57Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin tlyA p.Cys170Arg tlyA_p.Cys170Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.169800530161289 Inf 0.131195335276967 59 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin tlyA p.Cys86Arg tlyA_p.Cys86Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 3 0 2046 15483 0.00146412884333821 0.000302040401839334 0.00427278776332334 1 0.999761774846946 1 1 0.292401773821286 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 1.42021428525501 Inf 0.0136414077086102 20.5 2386 False False Inf 3.12435736045911 Inf 0.0009765625 0.000118288137154523 0.0035231826302861 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 3 0 1302 8642 0.00229885057471264 0.000474329389656033 0.00670338609202181 1 0.999573236258028 1 1 0.292401773821286 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 1.24514553843975 Inf 0.0171778483650829 16.5 1774 False False 0 0 0 0 0 0 0 Inf 2.73902522369248 Inf 0.00153374233128834 0.000185797311995654 0.00552931649023833 1 0.999573236258028 1 NA 3) Uncertain significance No change no 1 +Capreomycin tlyA p.Cys86fs tlyA_p.Cys86fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 2047 15483 0.000976085895558809 0.000118230396782607 0.00352146535805941 1 0.999761774846946 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 1.41952099860885 Inf 0.01365317821084 25.5 2386 False False Inf 1.41952099860885 Inf 0.000976085895558809 0.000118230396782607 0.00352146535805941 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 1303 8642 0.00153256704980842 0.000185654897205815 0.00552508794778556 1 0.999573236258028 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 1.24419098853007 Inf 0.0172007558014444 21.5 1774 False False 0 0 0 0 0 0 0 Inf 1.24419098853007 Inf 0.00153256704980842 0.000185654897205815 0.00552508794778556 1 0.999573236258028 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Cys86Gly tlyA_p.Cys86Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1442 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 966 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin tlyA p.Cys86Tyr tlyA_p.Cys86Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1459 2386 False False Inf 0.193753017505121 Inf 0 0 0.00179958946453767 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 979 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0 0 0.00282489773306727 1 0.999573236258028 1 1 3) Uncertain significance New Uncertain no 0 +Capreomycin tlyA p.Gln117* tlyA_p.Gln117* 1 stop_gained (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 2048 15482 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.99993541303365 0.999640197578315 0.999998364800924 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 7.5595703125 0.096257452000026 590.418198079286 0.220090832740563 119.5 2386 False False 7.5595703125 0.096257452000026 590.418198079286 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.169800530161289 Inf 0.131195335276967 59 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 4 Assoc w R Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Gln184fs tlyA_p.Gln184fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.169800530161289 Inf 0.131195335276967 59 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Gln184* tlyA_p.Gln184* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.169800530161289 Inf 0.131195335276967 59 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 3 Assoc w R Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Gln191fs tlyA_p.Gln191fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 2048 15482 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.99993541303365 0.999640197578315 0.999998364800924 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 293.494766828651 1 194.5 2386 False False 7.5595703125 0.096257452000026 590.418198079286 0 0 0.00179958946453767 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 1304 8641 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999884286044897 0.999355453609522 0.999997070380594 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 257.429115860043 1 503.5 1774 False False 0 0 0 0 0 0 0 6.62653374233128 0.0843535983905244 517.917818294861 0 0 0.00282489773306727 0.999884286044897 0.999355453609522 0.999997070380594 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Gln191His tlyA_p.Gln191His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin tlyA p.Gln21* tlyA_p.Gln21* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Assoc w R Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Gln22* tlyA_p.Gln22* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Assoc w R Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Glu132Ala tlyA_p.Glu132Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Capreomycin tlyA p.Glu132Gln tlyA_p.Glu132Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin tlyA p.Glu132Gly tlyA_p.Glu132Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin tlyA p.Glu238Lys tlyA_p.Glu238Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin tlyA p.Glu25* tlyA_p.Glu25* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA Assoc w R Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Glu75Lys tlyA_p.Glu75Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin tlyA p.Gly138fs tlyA_p.Gly138fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 2048 15482 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.99993541303365 0.999640197578315 0.999998364800924 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 7.5595703125 0.096257452000026 590.418198079286 0.220090832740563 119.5 2386 False False 7.5595703125 0.096257452000026 590.418198079286 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Gly145Asn tlyA_p.Gly145Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin tlyA p.Gly188Glu tlyA_p.Gly188Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 35.2688392655279 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance No change no 1 +Capreomycin tlyA p.Gly190Arg tlyA_p.Gly190Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin tlyA p.Gly196Arg tlyA_p.Gly196Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin tlyA p.Gly232Asp tlyA_p.Gly232Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 22 20 2 21 2 2028 15481 0.0102489019033674 0.00635511128056527 0.0156240716423959 0.999870826067299 0.999533458063883 0.999984356054634 0.913043478260869 0.719620664090589 0.989290033962124 0.909090909090909 0.708387258446066 0.988794413975849 0.909090909090909 0.708387258446066 0.988794413975849 76.3362919132149 18.5148925880759 672.470004428053 3.77457210512688e-17 4 2386 True False 80.1531065088757 19.5613607044801 702.240385290394 0.009765625 0.00597501264624522 0.0150421017212931 0.999870826067299 0.999533458063883 0.999984356054634 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance 1 3 3 0 3 0 1302 8642 0.00229885057471264 0.000474329389656033 0.00670338609202181 1 0.999573236258028 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 2.73902522369248 Inf 0.00225365357559397 12 1774 False False 0 0 0 0 0 0 0 Inf 2.73902522369248 Inf 0.00229885057471264 0.000474329389656033 0.00670338609202181 1 0.999573236258028 1 8 Assoc w RI Evidence from ALL dataset only 2) Assoc w R - Interim No change yes ALL only 1 +Capreomycin tlyA p.Gly235Asp tlyA_p.Gly235Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin tlyA p.Gly36fs tlyA_p.Gly36fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.169800530161289 Inf 0.131195335276967 59 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Gly66fs tlyA_p.Gly66fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Gly66* tlyA_p.Gly66* 1 stop_gained (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1461 2386 False False Inf 0.193753017505121 Inf 0 0 0.00179958946453767 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 980 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0 0 0.00282489773306727 1 0.999573236258028 1 NA Assoc w R Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Gly83Cys tlyA_p.Gly83Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin tlyA p.Gly90Cys tlyA_p.Gly90Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.169800530161289 Inf 0.131195335276967 59 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 2 3) Uncertain significance New Uncertain no 0 +Capreomycin tlyA p.Gly94Ser tlyA_p.Gly94Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 2047 15483 0.000976085895558809 0.000118230396782607 0.00352146535805941 1 0.999761774846946 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 1.41952099860885 Inf 0.01365317821084 25.5 2386 False False Inf 1.41952099860885 Inf 0.000976085895558809 0.000118230396782607 0.00352146535805941 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 1303 8642 0.00153256704980842 0.000185654897205815 0.00552508794778556 1 0.999573236258028 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 1.24419098853007 Inf 0.0172007558014444 21.5 1774 False False 0 0 0 0 0 0 0 Inf 1.24419098853007 Inf 0.00153256704980842 0.000185654897205815 0.00552508794778556 1 0.999573236258028 1 1 3) Uncertain significance New Uncertain no 0 +Capreomycin tlyA p.Gly95Glu tlyA_p.Gly95Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 2047 15483 0.000976085895558809 0.000118230396782607 0.00352146535805941 1 0.999761774846946 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.193847623510372 Inf 0.116821630254976 39 2386 False False Inf 1.41952099860885 Inf 0.00048828125 1.23621345180143e-05 0.00271749449396634 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 1303 8642 0.00153256704980842 0.000185654897205815 0.00552508794778556 1 0.999573236258028 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.169930745364978 Inf 0.131107983108787 31 1774 False False 0 0 0 0 0 0 0 Inf 1.24419098853007 Inf 0.000766871165644171 1.94153084409271e-05 0.00426525037799214 1 0.999573236258028 1 6 3) Uncertain significance No change no 1 +Capreomycin tlyA p.His199fs tlyA_p.His199fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.His68_Leu70dup tlyA_p.His68_Leu70dup 1 inframe_insertion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.169800530161289 Inf 0.131195335276967 59 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 NA 3) Uncertain significance No change no 1 +Capreomycin tlyA p.His68Arg tlyA_p.His68Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 0 13 2049 15470 0 0 0.00179871197794837 0.999160369437447 0.998564634148971 0.999552858749588 0 0 0.24705263800047 0 0 0.369416647552819 0 0 0.24705263800047 0 0 4.42651627807919 0.608186198068589 161 2386 False False 0 0 2.47945785793639 0 0 0.00179871197794837 0.999160369437447 0.998564634148971 0.999552858749588 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 257.173353425001 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 11 3) Uncertain significance No change no 1 +Capreomycin tlyA p.His68fs tlyA_p.His68fs 1 frameshift (see "Genomic_coordinates" sheet) 1 7 5 2 5 2 2044 15481 0.00244021473889702 0.000792791037816739 0.00568538572188254 0.999870826067299 0.999533458063883 0.999984356054634 0.714285714285714 0.290420863737342 0.963307433823914 0.714285714285714 0.290420863737342 0.963307433823914 0.714285714285714 0.290420863737342 0.963307433823914 18.934686888454 3.09626959191753 198.49398061237 0.000371739760896108 12 2386 False False 18.934686888454 3.09626959191753 198.49398061237 0.00244021473889702 0.000792791037816739 0.00568538572188254 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 4 1 4 1 1301 8641 0.00306513409961685 0.000835757856895071 0.00782921001204628 0.999884286044897 0.999355453609522 0.999997070380594 0.8 0.28358206388191 0.994949236620532 0.8 0.28358206388191 0.994949236620532 0.8 0.28358206388191 0.994949236620532 26.5672559569561 2.62471114562733 1298.18113593707 0.00132095170289282 8 1774 False False 0 0 0 0 0 0 0 26.5672559569561 2.62471114562733 1298.18113593707 0.00306513409961685 0.000835757856895071 0.00782921001204628 0.999884286044897 0.999355453609522 0.999997070380594 4 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Ile144fs tlyA_p.Ile144fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Ile177Thr tlyA_p.Ile177Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin tlyA p.Ile27fs tlyA_p.Ile27fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 2047 15483 0.000976085895558809 0.000118230396782607 0.00352146535805941 1 0.999761774846946 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 1.41952099860885 Inf 0.01365317821084 25.5 2386 False False Inf 1.41952099860885 Inf 0.000976085895558809 0.000118230396782607 0.00352146535805941 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 1303 8642 0.00153256704980842 0.000185654897205815 0.00552508794778556 1 0.999573236258028 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 1.24419098853007 Inf 0.0172007558014444 21.5 1774 False False 0 0 0 0 0 0 0 Inf 1.24419098853007 Inf 0.00153256704980842 0.000185654897205815 0.00552508794778556 1 0.999573236258028 1 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Ile27Val tlyA_p.Ile27Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 4 3) Uncertain significance New Uncertain no 0 +Capreomycin tlyA p.Ile34fs tlyA_p.Ile34fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.169800530161289 Inf 0.131195335276967 59 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Ile34Thr tlyA_p.Ile34Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance No change no 1 +Capreomycin tlyA p.Leu100Pro tlyA_p.Leu100Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.169800530161289 Inf 0.131195335276967 59 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin tlyA p.Leu101Pro tlyA_p.Leu101Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.169800530161289 Inf 0.131195335276967 59 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin tlyA p.Leu11Arg tlyA_p.Leu11Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.169800530161289 Inf 0.131195335276967 59 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin tlyA p.Leu122Arg tlyA_p.Leu122Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin tlyA p.Leu131fs tlyA_p.Leu131fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 2047 15483 0.000976085895558809 0.000118230396782607 0.00352146535805941 1 0.999761774846946 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 1.41952099860885 Inf 0.01365317821084 25.5 2386 False False Inf 1.41952099860885 Inf 0.000976085895558809 0.000118230396782607 0.00352146535805941 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.169800530161289 Inf 0.131195335276967 59 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Leu139Arg tlyA_p.Leu139Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.169800530161289 Inf 0.131195335276967 59 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin tlyA p.Leu139fs tlyA_p.Leu139fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1452 2386 False False Inf 0.193753017505121 Inf 0 0 0.00179958946453767 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 973 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0 0 0.00282489773306727 1 0.999573236258028 1 3 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Leu150Pro tlyA_p.Leu150Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 3 0 3 0 2046 15483 0.00146412884333821 0.000302040401839334 0.00427278776332334 1 0.999761774846946 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 3.12435736045911 Inf 0.00159429867641697 15 2386 False False Inf 3.12435736045911 Inf 0.00146412884333821 0.000302040401839334 0.00427278776332334 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin tlyA p.Leu155Arg tlyA_p.Leu155Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Capreomycin tlyA p.Leu160Trp tlyA_p.Leu160Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 2048 15482 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.99993541303365 0.999640197578315 0.999998364800924 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 7.5595703125 0.096257452000026 590.418198079286 0.220090832740563 119.5 2386 False False 7.5595703125 0.096257452000026 590.418198079286 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 1304 8641 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999884286044897 0.999355453609522 0.999997070380594 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 6.62653374233128 0.0843535983905244 517.917818294861 0.245189914752491 93.5 1774 False False 0 0 0 0 0 0 0 6.62653374233128 0.0843535983905244 517.917818294861 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin tlyA p.Leu180Arg tlyA_p.Leu180Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 2047 15483 0.000976085895558809 0.000118230396782607 0.00352146535805941 1 0.999761774846946 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1453 2386 False False Inf 1.41952099860885 Inf 0 0 0.00180046780769359 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 1303 8642 0.00153256704980842 0.000185654897205815 0.00552508794778556 1 0.999573236258028 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 974 1774 False False 0 0 0 0 0 0 0 Inf 1.24419098853007 Inf 0 0 0.00282706266083767 1 0.999573236258028 1 1 3) Uncertain significance No change no 1 +Capreomycin tlyA p.Leu209dup tlyA_p.Leu209dup 1 inframe_insertion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.169800530161289 Inf 0.131195335276967 59 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin tlyA p.Leu209fs tlyA_p.Leu209fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.169800530161289 Inf 0.131195335276967 59 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Leu218Met tlyA_p.Leu218Met 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 1 2045 15482 0.00195217179111761 0.00053214923576723 0.00499072666314977 0.99993541303365 0.999640197578315 0.999998364800924 0.8 0.28358206388191 0.994949236620532 NA NA NA 0 0 0.975 NA NA NA NA 1447 2386 False False 30.282640586797 2.99371232722536 1477.82550656403 0 0 0.00180222706872706 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 1 1301 8641 0.00306513409961685 0.000835757856895071 0.00782921001204628 0.999884286044897 0.999355453609522 0.999997070380594 0.8 0.28358206388191 0.994949236620532 NA NA NA 0 0 0.975 NA NA NA NA 969 1774 False False 0 0 0 0 0 0 0 26.5672559569561 2.62471114562733 1298.18113593707 0 0 0.00283140248651778 0.999884286044897 0.999355453609522 0.999997070380594 7 3) Uncertain significance No change no 1 +Capreomycin tlyA p.Leu218Pro tlyA_p.Leu218Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.169800530161289 Inf 0.131195335276967 59 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 3 3) Uncertain significance New Uncertain no 0 +Capreomycin tlyA p.Leu241Pro tlyA_p.Leu241Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.169800530161289 Inf 0.131195335276967 59 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin tlyA p.Leu74fs tlyA_p.Leu74fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 2047 15483 0.000976085895558809 0.000118230396782607 0.00352146535805941 1 0.999761774846946 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 1.41952099860885 Inf 0.01365317821084 25.5 2386 False False Inf 1.41952099860885 Inf 0.000976085895558809 0.000118230396782607 0.00352146535805941 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 1303 8642 0.00153256704980842 0.000185654897205815 0.00552508794778556 1 0.999573236258028 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 1.24419098853007 Inf 0.0172007558014444 21.5 1774 False False 0 0 0 0 0 0 0 Inf 1.24419098853007 Inf 0.00153256704980842 0.000185654897205815 0.00552508794778556 1 0.999573236258028 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Leu74Pro tlyA_p.Leu74Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 4 0 6 0 2043 15483 0.00292825768667642 0.00107535359935202 0.00636260998410225 1 0.999761774846946 1 1 0.540741873560099 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 4.99766079448691 Inf 0.000185446511257607 10 2386 True False Inf 8.91348295326886 Inf 0.00195407914020517 0.000532669409489338 0.00499559536386294 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 4 0 6 0 1299 8642 0.00459770114942528 0.00168908761569561 0.00998021295727147 1 0.999573236258028 1 1 0.540741873560099 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 4.38475718881067 Inf 0.000293507327154101 7 1774 False False 0 0 0 0 0 0 0 Inf 7.81922109072008 Inf 0.00306983883346124 0.0008370416198264 0.007841198419823 1 0.999573236258028 1 5 Assoc w R 3) Uncertain significance DOWN from AwR to Uncertain yes 2 +Capreomycin tlyA p.Leu87Arg tlyA_p.Leu87Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.169800530161289 Inf 0.131195335276967 59 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin tlyA p.Leu87Pro tlyA_p.Leu87Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 293.33332543886 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 978 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 3 3) Uncertain significance No change no 1 +Capreomycin tlyA p.Lys182Arg tlyA_p.Lys182Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin tlyA p.Lys189Asn tlyA_p.Lys189Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 18.2980327465689 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 16.0319456706962 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin tlyA p.Lys189fs tlyA_p.Lys189fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Lys226fs tlyA_p.Lys226fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 2048 15482 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.99993541303365 0.999640197578315 0.999998364800924 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 7.5595703125 0.096257452000026 590.418198079286 0.220090832740563 119.5 2386 False False 7.5595703125 0.096257452000026 590.418198079286 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Lys31fs tlyA_p.Lys31fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.169800530161289 Inf 0.131195335276967 59 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Lys69Glu tlyA_p.Lys69Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 293.33332543886 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 972 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin tlyA p.Lys69Thr tlyA_p.Lys69Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin tlyA p.Met1? tlyA_p.Met1? 1 start_lost (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.169800530161289 Inf 0.131195335276967 59 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim UP from Uncertain to AwRI no 4 +Capreomycin tlyA p.Phe157Val tlyA_p.Phe157Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.169800530161289 Inf 0.131195335276967 59 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin tlyA p.Phe240Leu tlyA_p.Phe240Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 293.33332543886 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin tlyA p.Phe77_Ala78dup tlyA_p.Phe77_Ala78dup 1 inframe_insertion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin tlyA p.Phe77fs tlyA_p.Phe77fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.169800530161289 Inf 0.131195335276967 59 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Pro126fs tlyA_p.Pro126fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 2047 15483 0.000976085895558809 0.000118230396782607 0.00352146535805941 1 0.999761774846946 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 1.41952099860885 Inf 0.01365317821084 25.5 2386 False False Inf 1.41952099860885 Inf 0.000976085895558809 0.000118230396782607 0.00352146535805941 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 1303 8642 0.00153256704980842 0.000185654897205815 0.00552508794778556 1 0.999573236258028 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 1.24419098853007 Inf 0.0172007558014444 21.5 1774 False False 0 0 0 0 0 0 0 Inf 1.24419098853007 Inf 0.00153256704980842 0.000185654897205815 0.00552508794778556 1 0.999573236258028 1 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Pro179Ala tlyA_p.Pro179Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 2048 15482 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.99993541303365 0.999640197578315 0.999998364800924 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 7.5595703125 0.096257452000026 590.418198079286 0.220090832740563 119.5 2386 False False 7.5595703125 0.096257452000026 590.418198079286 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 1304 8641 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999884286044897 0.999355453609522 0.999997070380594 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 6.62653374233128 0.0843535983905244 517.917818294861 0.245189914752491 93.5 1774 False False 0 0 0 0 0 0 0 6.62653374233128 0.0843535983905244 517.917818294861 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance No change no 1 +Capreomycin tlyA p.Pro179Ser tlyA_p.Pro179Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 31 3) Uncertain significance No change no 1 +Capreomycin tlyA p.Pro194Ser tlyA_p.Pro194Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1455 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 975 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin tlyA p.Pro229Arg tlyA_p.Pro229Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin tlyA p.Pro233fs tlyA_p.Pro233fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.169800530161289 Inf 0.131195335276967 59 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 3 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Pro233Ser tlyA_p.Pro233Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin tlyA p.Ser121Leu tlyA_p.Ser121Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 35.2688392655279 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin tlyA p.Ser156Ala tlyA_p.Ser156Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1446 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 968 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 7 3) Uncertain significance No change no 1 +Capreomycin tlyA p.Ser156del tlyA_p.Ser156del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 3 3 0 3 0 2046 15483 0.00146412884333821 0.000302040401839334 0.00427278776332334 1 0.999761774846946 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 3.12435736045911 Inf 0.00159429867641697 15 2386 False False Inf 3.12435736045911 Inf 0.00146412884333821 0.000302040401839334 0.00427278776332334 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 3 0 3 0 1302 8642 0.00229885057471264 0.000474329389656033 0.00670338609202181 1 0.999573236258028 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 2.73902522369248 Inf 0.00225365357559397 12 1774 False False 0 0 0 0 0 0 0 Inf 2.73902522369248 Inf 0.00229885057471264 0.000474329389656033 0.00670338609202181 1 0.999573236258028 1 4 3) Uncertain significance New Uncertain no 0 +Capreomycin tlyA p.Ser156* tlyA_p.Ser156* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.169800530161289 Inf 0.131195335276967 59 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 NA Assoc w R Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Ser159* tlyA_p.Ser159* 1 stop_gained (see "Genomic_coordinates" sheet) 1 4 3 1 3 1 2046 15482 0.00146412884333821 0.000302040401839334 0.00427278776332334 0.99993541303365 0.999640197578315 0.999998364800924 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 22.7008797653958 1.82106780131754 1182.67641217355 0.00581893095554824 18 2386 False False 22.7008797653958 1.82106780131754 1182.67641217355 0.00146412884333821 0.000302040401839334 0.00427278776332334 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 3 1 3 1 1302 8641 0.00229885057471264 0.000474329389656033 0.00670338609202181 0.999884286044897 0.999355453609522 0.999997070380594 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 19.9101382488479 1.5964708891405 1038.40452300413 0.00812937990311301 15 1774 False False 0 0 0 0 0 0 0 19.9101382488479 1.5964708891405 1038.40452300413 0.00229885057471264 0.000474329389656033 0.00670338609202181 0.999884286044897 0.999355453609522 0.999997070380594 1 Assoc w R Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Ser172fs tlyA_p.Ser172fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Ser207fs tlyA_p.Ser207fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.169800530161289 Inf 0.131195335276967 59 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Ser228Arg tlyA_p.Ser228Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 1 2045 15482 0.00195217179111761 0.00053214923576723 0.00499072666314977 0.99993541303365 0.999640197578315 0.999998364800924 0.8 0.28358206388191 0.994949236620532 NA NA NA 0 0 0.975 NA NA NA NA 1456 2386 False False 30.282640586797 2.99371232722536 1477.82550656403 0 0 0.00180222706872706 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 1 1301 8641 0.00306513409961685 0.000835757856895071 0.00782921001204628 0.999884286044897 0.999355453609522 0.999997070380594 0.8 0.28358206388191 0.994949236620532 NA NA NA 0 0 0.975 NA NA NA NA 976 1774 False False 0 0 0 0 0 0 0 26.5672559569561 2.62471114562733 1298.18113593707 0 0 0.00283140248651778 0.999884286044897 0.999355453609522 0.999997070380594 8 3) Uncertain significance No change no 1 +Capreomycin tlyA p.Ser228fs tlyA_p.Ser228fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Ser234fs tlyA_p.Ser234fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1443 2386 False False Inf 0.193753017505121 Inf 0 0 0.00179958946453767 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 967 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0 0 0.00282489773306727 1 0.999573236258028 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Ser252fs tlyA_p.Ser252fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 2 1 2047 15482 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.99993541303365 0.999640197578315 0.999998364800924 0.666666666666666 0.0942993240502461 0.991596241340387 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.193835103475189 Inf 0.116828294352538 41 2386 False False 15.1265266243282 0.786906901669143 886.86117101553 0.00048828125 1.23621345180143e-05 0.00271749449396634 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 1 1303 8641 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.999884286044897 0.999355453609522 0.999997070380594 0.666666666666666 0.0942993240502461 0.991596241340387 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.169911081995298 Inf 0.131121166415284 33 1774 False False 0 0 0 0 0 0 0 13.2632386799693 0.689686563300777 778.308617525017 0.000766871165644171 1.94153084409271e-05 0.00426525037799214 0.999884286044897 0.999355453609522 0.999997070380594 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Ser252Leu tlyA_p.Ser252Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin tlyA p.Ser92fs tlyA_p.Ser92fs 1 frameshift (see "Genomic_coordinates" sheet) 1 4 4 0 4 1 2045 15482 0.00195217179111761 0.00053214923576723 0.00499072666314977 0.99993541303365 0.999640197578315 0.999998364800924 0.8 0.28358206388191 0.994949236620532 1 0.397635364383525 1 0.8 0.28358206388191 0.994949236620532 Inf 4.99245561773049 Inf 0.000186130383141216 11 2386 True False 30.282640586797 2.99371232722536 1477.82550656403 0.00195217179111761 0.00053214923576723 0.00499072666314977 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 1303 8642 0.00153256704980842 0.000185654897205815 0.00552508794778556 1 0.999573236258028 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 1.24419098853007 Inf 0.0172007558014444 21.5 1774 False False 0 0 0 0 0 0 0 Inf 1.24419098853007 Inf 0.00153256704980842 0.000185654897205815 0.00552508794778556 1 0.999573236258028 1 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Ter269Trpext*? tlyA_p.Ter269Trpext*? 1 stop_lost (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 18.2980327465689 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin tlyA p.Thr134fs tlyA_p.Thr134fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 2047 15483 0.000976085895558809 0.000118230396782607 0.00352146535805941 1 0.999761774846946 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.193847623510372 Inf 0.116821630254976 39 2386 False False Inf 1.41952099860885 Inf 0.00048828125 1.23621345180143e-05 0.00271749449396634 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 1303 8642 0.00153256704980842 0.000185654897205815 0.00552508794778556 1 0.999573236258028 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.169930745364978 Inf 0.131107983108787 31 1774 False False 0 0 0 0 0 0 0 Inf 1.24419098853007 Inf 0.000766871165644171 1.94153084409271e-05 0.00426525037799214 1 0.999573236258028 1 5 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Thr134Ile tlyA_p.Thr134Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin tlyA p.Thr162fs tlyA_p.Thr162fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Thr245fs tlyA_p.Thr245fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.169800530161289 Inf 0.131195335276967 59 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 3 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Thr50fs tlyA_p.Thr50fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.169800530161289 Inf 0.131195335276967 59 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Thr97Pro tlyA_p.Thr97Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin tlyA p.Trp220fs tlyA_p.Trp220fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.169800530161289 Inf 0.131195335276967 59 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Trp62fs tlyA_p.Trp62fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Tyr239fs tlyA_p.Tyr239fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1448 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Val108Ala tlyA_p.Val108Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin tlyA p.Val130fs tlyA_p.Val130fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Val151Ile tlyA_p.Val151Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 293.33332543886 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 981 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance No change no 1 +Capreomycin tlyA p.Val178Ala tlyA_p.Val178Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1444 2386 False False Inf 0.193753017505121 Inf 0 0 0.00179958946453767 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin tlyA p.Val181fs tlyA_p.Val181fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.169800530161289 Inf 0.131195335276967 59 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Val181Gly tlyA_p.Val181Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.169800530161289 Inf 0.131195335276967 59 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin tlyA p.Val197fs tlyA_p.Val197fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Val198fs tlyA_p.Val198fs 1 frameshift (see "Genomic_coordinates" sheet) 1 10 9 1 9 1 2040 15482 0.00439238653001464 0.00201038610804174 0.00832167289780672 0.99993541303365 0.999640197578315 0.999998364800924 0.9 0.554983882971804 0.997471421455538 0.9 0.554983882971804 0.997471421455538 0.9 0.554983882971804 0.997471421455538 68.3029411764705 9.45085200692327 2941.88123303128 3.58572428594218e-08 7 2386 True False 68.3029411764705 9.45085200692327 2941.88123303128 0.00439238653001464 0.00201038610804174 0.00832167289780672 0.99993541303365 0.999640197578315 0.999998364800924 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance 1 3 3 0 3 0 1302 8642 0.00229885057471264 0.000474329389656033 0.00670338609202181 1 0.999573236258028 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 2.73902522369248 Inf 0.00225365357559397 12 1774 False False 0 0 0 0 0 0 0 Inf 2.73902522369248 Inf 0.00229885057471264 0.000474329389656033 0.00670338609202181 1 0.999573236258028 1 3 Evidence from ALL dataset only 2) Assoc w R - Interim No change no ALL only 1 +Capreomycin tlyA p.Val198Gly tlyA_p.Val198Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance No change no 1 +Capreomycin tlyA p.Val223fs tlyA_p.Val223fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.169800530161289 Inf 0.131195335276967 59 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Val32Leu tlyA_p.Val32Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1449 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 970 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 41 3) Uncertain significance No change no 1 +Capreomycin tlyA p.Val46fs tlyA_p.Val46fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Val46Glu tlyA_p.Val46Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 3 0 2046 15483 0.00146412884333821 0.000302040401839334 0.00427278776332334 1 0.999761774846946 1 1 0.292401773821286 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 1.42021428525501 Inf 0.0136414077086102 20.5 2386 False False Inf 3.12435736045911 Inf 0.0009765625 0.000118288137154523 0.0035231826302861 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 3 0 1302 8642 0.00229885057471264 0.000474329389656033 0.00670338609202181 1 0.999573236258028 1 1 0.292401773821286 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 1.24514553843975 Inf 0.0171778483650829 16.5 1774 False False 0 0 0 0 0 0 0 Inf 2.73902522369248 Inf 0.00153374233128834 0.000185797311995654 0.00552931649023833 1 0.999573236258028 1 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin tlyA p.Val54fs tlyA_p.Val54fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.169800530161289 Inf 0.131195335276967 59 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Capreomycin tlyA p.Val54Gly tlyA_p.Val54Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 3 0 3 0 2046 15483 0.00146412884333821 0.000302040401839334 0.00427278776332334 1 0.999761774846946 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 3.12435736045911 Inf 0.00159429867641697 15 2386 False False Inf 3.12435736045911 Inf 0.00146412884333821 0.000302040401839334 0.00427278776332334 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 3 0 3 0 1302 8642 0.00229885057471264 0.000474329389656033 0.00670338609202181 1 0.999573236258028 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 2.73902522369248 Inf 0.00225365357559397 12 1774 False False 0 0 0 0 0 0 0 Inf 2.73902522369248 Inf 0.00229885057471264 0.000474329389656033 0.00670338609202181 1 0.999573236258028 1 2 3) Uncertain significance New Uncertain no 0 +Capreomycin tlyA p.Val7Phe tlyA_p.Val7Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin tlyA p.Val99Ile tlyA_p.Val99Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.-100G>A whiB6_c.-100G>A 2 upstream_gene_variant 4338621 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1464 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 985 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 9 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.-103C>G whiB6_c.-103C>G 2 upstream_gene_variant 4338624 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1534 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1033 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-103C>T whiB6_c.-103C>T 2 upstream_gene_variant 4338624 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 35.2688392655279 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 3 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-104C>T whiB6_c.-104C>T 2 upstream_gene_variant 4338625 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-109C>A whiB6_c.-109C>A 2 upstream_gene_variant 4338630 1 5 0 5 0 7 2049 15476 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 0 0 0.409616397225003 0 0 0.521823750104981 0 0 0.409616397225003 0 0 8.24789386425432 1 619.5 2386 False False 0 0 5.24430081649792 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 7 1305 8635 0 0 0.00282273611850443 0.999190002314279 0.998331811834773 0.999674278877205 0 0 0.409616397225003 0 0 0.521823750104981 0 0 0.409616397225003 0 0 7.22847167093785 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 4.59639609856608 0 0 0.00282273611850443 0.999190002314279 0.998331811834773 0.999674278877205 32 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.-110T>C whiB6_c.-110T>C 2 upstream_gene_variant 4338631 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.-110T>G whiB6_c.-110T>G 2 upstream_gene_variant 4338631 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 4 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-112_-111insTTAACAGG whiB6_c.-112_-111insTTAACAGG 2 upstream_gene_variant 4338632 1 3 0 3 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 18.2980327465689 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-112G>C whiB6_c.-112G>C 2 upstream_gene_variant 4338633 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1519 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1023 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-113G>C whiB6_c.-113G>C 2 upstream_gene_variant 4338634 1 1 0 1 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 293.33332543886 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1016 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 4 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.-114A>C whiB6_c.-114A>C 2 upstream_gene_variant 4338635 1 17 0 17 0 30 2049 15453 0 0 0.00179871197794837 0.998062391009494 0.99723508866369 0.998692333308913 0 0 0.115703308222027 0 0 0.195064322969093 0 0 0.115703308222027 0 0 1.82933400189632 0.249376299053008 131 2386 False False 0 0 0.987754865365248 0 0 0.00179871197794837 0.998062391009494 0.99723508866369 0.998692333308913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 10 1305 8632 0 0 0.00282273611850443 0.99884286044897 0.997873012135272 0.999444971558315 0 0 0.30849710781876 0 0 0.4592581264399 0 0 0.30849710781876 0 0 5.62422884656198 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 2.9548002607889 0 0 0.00282273611850443 0.99884286044897 0.997873012135272 0.999444971558315 80 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.-114A>G whiB6_c.-114A>G 2 upstream_gene_variant 4338635 1 4 0 4 1 5 2048 15478 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999677065168249 0.999246540104889 0.9998951358908 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.602364635616474 0 0 0.521823750104981 0 0 11.4553414106133 1 619.5 2386 False False 1.5115234375 0.0319423199882685 13.5174010142692 0 0 0.00179958946453767 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 3 1304 8639 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999652858134691 0.998985842622235 0.999928405279598 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 16.0442452167038 1 503.5 1774 False False 0 0 0 0 0 0 0 2.20833333333333 0.0420336930075031 27.526218938507 0 0 0.00282489773306727 0.999652858134691 0.998985842622235 0.999928405279598 2 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.-114A>T whiB6_c.-114A>T 2 upstream_gene_variant 4338635 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.-115_-114insT whiB6_c.-115_-114insT 2 upstream_gene_variant 4338635 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.-115_-23delCAGGATCTATGCCCTGGTACTCGGCGGTGCGCGCACTAGAGCTCGGAGCTCGCCGAACCGGAGCCGCAGCACCGCTAGGCAGGCAGAGGAGGA whiB6_c.-115_-23delCAGGATCTATGCCCTGGTACTCGGCGGTGCGCGCACTAGAGCTCGGAGCTCGCCGAACCGGAGCCGCAGCACCGCTAGGCAGGCAGAGGAGGA 2 upstream_gene_variant 4338543 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-115C>A whiB6_c.-115C>A 2 upstream_gene_variant 4338636 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1503 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1010 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 1 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.-116A>C whiB6_c.-116A>C 2 upstream_gene_variant 4338637 1 1 0 1 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 293.314465539138 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1007 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 11 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-116A>G whiB6_c.-116A>G 2 upstream_gene_variant 4338637 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.-117A>G whiB6_c.-117A>G 2 upstream_gene_variant 4338638 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-118delT whiB6_c.-118delT 2 upstream_gene_variant 4338638 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1475 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 993 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.-122_-104delTGATTAACAGGATCTATGC whiB6_c.-122_-104delTGATTAACAGGATCTATGC 2 upstream_gene_variant 4338624 NA 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1540 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1038 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-122T>C whiB6_c.-122T>C 2 upstream_gene_variant 4338643 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1476 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.-123_-34delCTGATTAACAGGATCTATGCCCTGGTACTCGGCGGTGCGCGCACTAGAGCTCGGAGCTCGCCGAACCGGAGCCGCAGCACCGCTAGGCAG whiB6_c.-123_-34delCTGATTAACAGGATCTATGCCCTGGTACTCGGCGGTGCGCGCACTAGAGCTCGGAGCTCGCCGAACCGGAGCCGCAGCACCGCTAGGCAG 2 upstream_gene_variant 4338554 NA 0 0 0 2 0 2047 15483 0.000976085895558809 0.000118230396782607 0.00352146535805941 1 0.999761774846946 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1462 2386 False False Inf 1.41952099860885 Inf 0 0 0.00180046780769359 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-125A>C whiB6_c.-125A>C 2 upstream_gene_variant 4338646 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1468 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.-125A>G whiB6_c.-125A>G 2 upstream_gene_variant 4338646 1 4 0 4 0 8 2049 15475 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 0 0 0.369416647552819 0 0 0.602364635616474 0 0 0.369416647552819 0 0 11.44752945988 1 619.5 2386 False False 0 0 4.42794679154129 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 35.2606789358977 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 7 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.-126C>G whiB6_c.-126C>G 2 upstream_gene_variant 4338647 1 0 0 0 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1490 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1001 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.-126C>T whiB6_c.-126C>T 2 upstream_gene_variant 4338647 1 3 0 3 1 3 2048 15480 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999806239100949 0.999433853882399 0.999960040061829 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 18.30693542144 1 619.5 2386 False False 2.51953125 0.047970285762596 31.379124977949 0 0 0.00179958946453767 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 5 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.12T>C whiB6_c.12T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin whiB6 c.-12T>C whiB6_c.-12T>C 2 upstream_gene_variant 4338533 1 4 0 4 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 11.4504880046624 1 619.5 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.138C>T whiB6_c.138C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 40.2367591624089 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 35.2688392655279 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin whiB6 c.-14C>T whiB6_c.-14C>T 2 upstream_gene_variant 4338535 1 3 0 3 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 18.2956781909983 1 619.5 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 35.2688392655279 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 26 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.150G>A whiB6_c.150G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 18.2980327465689 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin whiB6 c.-15G>T whiB6_c.-15G>T 2 upstream_gene_variant 4338536 NA 0 0 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1524 2386 False False Inf 0.193753017505121 Inf 0 0 0.00179958946453767 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-16T>C whiB6_c.-16T>C 2 upstream_gene_variant 4338537 1 10 0 10 0 10 2049 15473 0 0 0.00179871197794837 0.999354130336498 0.998812544515655 0.999690238326549 0 0 0.30849710781876 0 0 0.30849710781876 0 0 0.30849710781876 0 0 3.37173073063401 0.618030833786075 174.5 2386 False False 0 0 3.37173073063401 0 0 0.00179871197794837 0.999354130336498 0.998812544515655 0.999690238326549 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 10.0364048825129 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 38 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.171G>A whiB6_c.171G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin whiB6 c.174C>T whiB6_c.174C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin whiB6 c.-17T>C whiB6_c.-17T>C 2 upstream_gene_variant 4338538 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.-184_-44del whiB6_c.-184_-44del 2 upstream_gene_variant 4338564 1 4 0 4 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 11.4504880046624 1 619.5 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-186_-29del whiB6_c.-186_-29del 2 upstream_gene_variant 4338549 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.18G>A whiB6_c.18G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin whiB6 c.-190_-40del whiB6_c.-190_-40del 2 upstream_gene_variant 4338560 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-192_-110delGTCAGAACACTTTTCCTGGAAGATCTGCCCGAAGGGGTCGGATACGCGCCGGCGAGGCCAGATACACAGCTGATTAACAGGAT whiB6_c.-192_-110delGTCAGAACACTTTTCCTGGAAGATCTGCCCGAAGGGGTCGGATACGCGCCGGCGAGGCCAGATACACAGCTGATTAACAGGAT 2 upstream_gene_variant 4338630 1 8 0 8 2 14 2047 15469 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.999095782471097 0.998483341560662 0.999505570487652 0.125 0.0155136038154138 0.383476236849263 0 0 0.369416647552819 0 0 0.231635761650116 0 0 4.43055765562307 0.608209397855383 168 2386 False False 1.07955893642263 0.118984769392524 4.70616521734574 0 0 0.00180046780769359 0.999095782471097 0.998483341560662 0.999505570487652 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.192C>A whiB6_c.192C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin whiB6 c.-195_-93del whiB6_c.-195_-93del 2 upstream_gene_variant 4338613 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.195C>T whiB6_c.195C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin whiB6 c.-198_-31del whiB6_c.-198_-31del 2 upstream_gene_variant 4338551 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1529 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1029 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-198_-42del whiB6_c.-198_-42del 2 upstream_gene_variant 4338562 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.198C>T whiB6_c.198C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin whiB6 c.-19T>C whiB6_c.-19T>C 2 upstream_gene_variant 4338540 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.1A>G whiB6_c.1A>G 2 initiator_codon_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 11.4504880046624 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.0364048825129 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin whiB6 c.-205_-62del whiB6_c.-205_-62del 2 upstream_gene_variant 4338582 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-206_-65del whiB6_c.-206_-65del 2 upstream_gene_variant 4338585 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.213T>C whiB6_c.213T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin whiB6 c.21A>G whiB6_c.21A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin whiB6 c.-21A>G whiB6_c.-21A>G 2 upstream_gene_variant 4338542 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 35.2688392655279 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 2 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-22A>G whiB6_c.-22A>G 2 upstream_gene_variant 4338543 NA 0 0 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1486 2386 False False Inf 0.193753017505121 Inf 0 0 0.00179958946453767 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-240_-28del whiB6_c.-240_-28del 2 upstream_gene_variant 4338548 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-24G>A whiB6_c.-24G>A 2 upstream_gene_variant 4338545 1 2 0 2 0 6 2049 15477 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 0 0 0.4592581264399 0 0 0.841886116991581 0 0 0.4592581264399 0 0 40.2263763905443 1 194.5 2386 False False 0 0 6.41986758323506 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 35.2606789358977 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 7 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.-24G>C whiB6_c.-24G>C 2 upstream_gene_variant 4338545 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1530 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.-24G>T whiB6_c.-24G>T 2 upstream_gene_variant 4338545 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.252A>G whiB6_c.252A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 40.2367591624089 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin whiB6 c.258G>A whiB6_c.258G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin whiB6 c.-26A>G whiB6_c.-26A>G 2 upstream_gene_variant 4338547 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 10 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.-27_-26insG whiB6_c.-27_-26insG 2 upstream_gene_variant 4338547 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1482 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 997 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-27G>A whiB6_c.-27G>A 2 upstream_gene_variant 4338548 1 5 0 5 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 8.24895966345574 1 194.5 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 16.0319456706962 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 2 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.-27G>C whiB6_c.-27G>C 2 upstream_gene_variant 4338548 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1522 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1026 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.288A>G whiB6_c.288A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 16 56 2033 15427 0.00780868716447047 0.00446973512241491 0.0126499212167889 0.996383129884389 0.995305730726477 0.997266733459874 0.222222222222222 0.13268238478784 0.335636627854692 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.16808376080387 1.15846665799071 3.84211187810281 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 13 51 1292 8591 0.00996168582375479 0.00531453846250247 0.0169745442936001 0.994098588289747 0.99224794701124 0.995602947677035 0.203125 0.11282885947084 0.32226430670804 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.69494020518424 0.84315995880535 3.17258209129834 NA NA NA NA NA NA 26 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin whiB6 c.-29A>G whiB6_c.-29A>G 2 upstream_gene_variant 4338550 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-29A>T whiB6_c.-29A>T 2 upstream_gene_variant 4338550 1 1 0 1 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 0 0 0.975 0 0 0.521823750104981 0 0 293.276745706192 1 194.5 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 5 1305 8637 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 0 0 0.521823750104981 0 0 0.975 0 0 0.521823750104981 0 0 257.114061715895 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 7.23014561016525 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 10 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.-2T>C whiB6_c.-2T>C 2 upstream_gene_variant 4338523 1 2 0 2 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 40.2315677803598 1 619.5 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.303C>G whiB6_c.303C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin whiB6 c.309T>G whiB6_c.309T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 40.2367591624089 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin whiB6 c.30A>G whiB6_c.30A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin whiB6 c.-31A>G whiB6_c.-31A>G 2 upstream_gene_variant 4338552 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.324C>T whiB6_c.324C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin whiB6 c.330G>A whiB6_c.330G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 40.2367591624089 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin whiB6 c.-33G>A whiB6_c.-33G>A 2 upstream_gene_variant 4338554 NA 0 0 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1493 2386 False False Inf 0.193753017505121 Inf 0 0 0.00179958946453767 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1003 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0 0 0.00282489773306727 1 0.999573236258028 1 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-33G>C whiB6_c.-33G>C 2 upstream_gene_variant 4338554 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1504 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.-34G>A whiB6_c.-34G>A 2 upstream_gene_variant 4338555 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.-42G>T whiB6_c.-42G>T 2 upstream_gene_variant 4338563 NA 0 0 0 32 360 2017 15123 0.0156173743289409 0.0107061575234322 0.0219760827105501 0.976748692113931 0.97425113232056 0.979064834163455 0.0816326530612244 0.0565052691546081 0.113287652212165 NA NA NA 0 0 0.0101945668820123 NA NA NA NA NA NA False True 0.666468352338456 0.447676823703668 0.96130446661768 0 0 0.0018272227192117 0.976748692113931 0.97425113232056 0.979064834163455 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 30 350 1275 8292 0.0229885057471264 0.0155627332983086 0.0326558832080112 0.959500115713955 0.955128336994122 0.963558521804027 0.0789473684210526 0.0538974173091566 0.110785112065164 NA NA NA 0 0 0.0104843080319834 NA NA NA NA NA NA False True 0 1 1 0 0 1 0 0.55744537815126 0.368772161293775 0.814741697029774 0 0 0.00288905740575022 0.959500115713955 0.955128336994122 0.963558521804027 346 Not assoc w R 5) Not assoc w R No change yes 1 +Capreomycin whiB6 c.42T>G whiB6_c.42T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 40.2367591624089 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 35.2688392655279 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin whiB6 c.-44C>T whiB6_c.-44C>T 2 upstream_gene_variant 4338565 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1507 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1012 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 13 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.45C>T whiB6_c.45C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin whiB6 c.-46C>A whiB6_c.-46C>A 2 upstream_gene_variant 4338567 NA 0 0 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1520 2386 False False Inf 0.193753017505121 Inf 0 0 0.00179958946453767 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1024 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0 0 0.00282489773306727 1 0.999573236258028 1 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.49A>C whiB6_c.49A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 29 2047 15454 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.998126977975844 0.997311126912655 0.998745260027249 0.064516129032258 0.0079109834618547 0.214216157163402 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.520661017805703 0.0601628313584226 2.06078737638921 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 5 1305 8637 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 7.23014561016525 NA NA NA NA NA NA 32 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin whiB6 c.-49C>T whiB6_c.-49C>T 2 upstream_gene_variant 4338570 1 1 0 1 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 293.33332543886 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.51G>A whiB6_c.51G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.193753017505121 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin whiB6 c.-54A>G whiB6_c.-54A>G 2 upstream_gene_variant 4338575 1 17 0 17 0 24 2049 15459 0 0 0.00179871197794837 0.998449912807595 0.997694465417801 0.999006585264568 0 0 0.142473597722525 0 0 0.195064322969093 0 0 0.142473597722525 0 0 1.83004217672993 0.249348351603491 130 2386 False False 0 0 1.25473260291809 0 0 0.00179871197794837 0.998449912807595 0.997694465417801 0.999006585264568 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 5 1305 8637 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 0 0 0.521823750104981 0 0 0.975 0 0 0.521823750104981 0 0 257.114061715895 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 7.23014561016525 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 49 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.54C>T whiB6_c.54C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 2049 15477 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 6.41986758323506 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin whiB6 c.-57C>G whiB6_c.-57C>G 2 upstream_gene_variant 4338578 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1469 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 989 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-59A>C whiB6_c.-59A>C 2 upstream_gene_variant 4338580 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.-5G>A whiB6_c.-5G>A 2 upstream_gene_variant 4338526 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1541 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.-66T>C whiB6_c.-66T>C 2 upstream_gene_variant 4338587 1 1 0 1 1 1 2048 15482 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.99993541303365 0.999640197578315 0.999998364800924 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 293.494766828651 1 194.5 2386 False False 7.5595703125 0.096257452000026 590.418198079286 0 0 0.00179958946453767 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 28 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-68G>T whiB6_c.-68G>T 2 upstream_gene_variant 4338589 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1470 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-69A>C whiB6_c.-69A>C 2 upstream_gene_variant 4338590 1 6 0 6 0 6 2049 15477 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 6.41986758323506 1 619.5 2386 False False 0 0 6.41986758323506 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 1305 8636 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 5.62683462374212 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 5.62683462374212 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 74 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-69A>G whiB6_c.-69A>G 2 upstream_gene_variant 4338590 1 2 0 2 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 40.2315677803598 1 619.5 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1025 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-69A>T whiB6_c.-69A>T 2 upstream_gene_variant 4338590 1 4 0 4 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 11.4504880046624 1 619.5 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 10.0364048825129 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 19 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-70G>A whiB6_c.-70G>A 2 upstream_gene_variant 4338591 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 8 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-70G>C whiB6_c.-70G>C 2 upstream_gene_variant 4338591 1 12 1 11 12 15 2037 15468 0.00585651537335285 0.00302969927424994 0.0102077845176216 0.999031195504747 0.998402606935329 0.999457669301639 0.444444444444444 0.254798806631737 0.646735769677994 0.0833333333333333 0.00210759323186022 0.384796165150944 0.0625 0.00158111172276588 0.302320738434531 0.690319989289061 0.0160300315001335 4.75409585365013 1 194.5 2386 False False 6.07481590574374 2.5919002518157 13.9219362205263 0.000490677134445534 1.24227923086502e-05 0.0027308136650108 0.999031195504747 0.998402606935329 0.999457669301639 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 2 1303 8640 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.999768572089794 0.999164255486522 0.999971971777513 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 257.59619612607 1 503.5 1774 False False 0 0 0 0 0 0 0 6.63085188027628 0.480082065417988 91.6551467569938 0 0 0.00282706266083767 0.999768572089794 0.999164255486522 0.999971971777513 22 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-71G>A whiB6_c.-71G>A 2 upstream_gene_variant 4338592 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-71G>C whiB6_c.-71G>C 2 upstream_gene_variant 4338592 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 35.2688392655279 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 9 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-71G>T whiB6_c.-71G>T 2 upstream_gene_variant 4338592 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1544 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1040 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 20 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.72C>T whiB6_c.72C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 257.232645023805 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin whiB6 c.-74delC whiB6_c.-74delC 2 upstream_gene_variant 4338594 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1508 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1013 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.-75_-72delGCTCinsCAA whiB6_c.-75_-72delGCTCinsCAA 2 upstream_gene_variant 4338593 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1471 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 990 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-75_-72delGCTCinsCTG whiB6_c.-75_-72delGCTCinsCTG 2 upstream_gene_variant 4338593 1 3 0 3 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 18.2980327465689 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.-75_-72delGCTCinsCTT whiB6_c.-75_-72delGCTCinsCTT 2 upstream_gene_variant 4338593 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1521 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.-75_-73delGCTinsCA whiB6_c.-75_-73delGCTinsCA 2 upstream_gene_variant 4338594 1 10 0 10 2 14 2047 15469 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.999095782471097 0.998483341560662 0.999505570487652 0.125 0.0155136038154138 0.383476236849263 0 0 0.30849710781876 0 0 0.231635761650116 0 0 3.37415510385958 0.617984542646592 172 2386 False False 1.07955893642263 0.118984769392524 4.70616521734574 0 0 0.00180046780769359 0.999095782471097 0.998483341560662 0.999505570487652 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 4 1303 8638 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.999537144179588 0.998815333169806 0.999873873427139 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.975 0 0 0.602364635616474 0 0 257.53681419672 1 503.5 1774 False False 0 0 0 0 0 0 0 3.31465848042977 0.299500870485947 23.1496879983142 0 0 0.00282706266083767 0.999537144179588 0.998815333169806 0.999873873427139 31 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-75_-73delGCTinsCC whiB6_c.-75_-73delGCTinsCC 2 upstream_gene_variant 4338594 1 44 1 43 10 67 2039 15416 0.00488042947779404 0.0023427615854433 0.00895691175610291 0.995672673254537 0.994507660120316 0.99664485461915 0.129870129870129 0.0640731834559493 0.225895202218575 0.0227272727272727 0.000575239213363083 0.120241582206347 0.0147058823529411 0.00037225140289861 0.079233989912788 0.175827183868061 0.00435305592511545 1.03461007948446 0.0564190096114354 32 2386 False False 1.12844312034725 0.516748096773675 2.21086359829843 0.000490196078431372 1.24106131760805e-05 0.00272813939610212 0.995672673254537 0.994507660120316 0.99664485461915 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 25 1 24 6 44 1299 8598 0.00459770114942528 0.00168908761569561 0.00998021295727147 0.994908585975468 0.993170976757335 0.996298205909449 0.12 0.0453353207736638 0.243101316705562 0.04 0.00101219969931084 0.203516913922414 0.0222222222222222 0.000562459715402258 0.117704331418294 0.275789068514241 0.00670470572218961 1.69442087962707 0.241268297649885 88 1774 False False 0 0 0 0 0 0 0 0.902582406046609 0.313692373461561 2.13175171703796 0.000769230769230769 1.94750472697969e-05 0.00427835115532533 0.994908585975468 0.993170976757335 0.996298205909449 85 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-75_-73delGCTinsCG whiB6_c.-75_-73delGCTinsCG 2 upstream_gene_variant 4338594 1 19 0 19 4 60 2045 15423 0.00195217179111761 0.00053214923576723 0.00499072666314977 0.996124782018988 0.995014603666424 0.997041536920955 0.0625 0.0172900273810552 0.152363473422696 0 0 0.176466911806965 0 0 0.0596294922861668 0 0 1.61758771752423 0.156469783699084 109 2386 False False 0.502787286063569 0.132557731156823 1.35783998675263 0 0 0.00180222706872706 0.996124782018988 0.995014603666424 0.997041536920955 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 4 48 1301 8594 0.00306513409961685 0.000835757856895071 0.00782921001204628 0.994445730155056 0.992642512993299 0.995901964130712 0.0769230769230769 0.0213565864913836 0.185396604383411 0 0 0.336267116879942 0 0 0.0739727853472802 0 0 3.35102731175764 0.616655999390085 116 1774 False False 0 0 0 0 0 0 0 0.55047399436331 0.143907962209089 1.50720576655433 0 0 0.00283140248651778 0.994445730155056 0.992642512993299 0.995901964130712 38 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-75_-74delGCinsA whiB6_c.-75_-74delGCinsA 2 upstream_gene_variant 4338595 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-75_-74delGCinsT whiB6_c.-75_-74delGCinsT 2 upstream_gene_variant 4338595 1 3 0 3 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 18.2968554679321 1 619.5 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 16.0300905104715 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 11 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.-75_-74insA whiB6_c.-75_-74insA 2 upstream_gene_variant 4338595 1 0 0 0 0 6 2049 15477 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1494 2386 False False 0 0 6.41986758323506 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1004 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 10 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.75C>T whiB6_c.75C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 293.352185327417 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin whiB6 c.-75delG whiB6_c.-75delG 2 upstream_gene_variant 4338595 NA 0 0 0 1998 14998 51 485 0.97510980966325 0.967402650006331 0.981412765509524 0.0313246786798424 0.0286369328503472 0.0341903498373545 0.117557072252294 0.112751191405599 0.122494243781483 NA NA NA 0 0 0.000245927846141493 NA NA NA NA 1465 2386 False True 1.2668747989928 0.944013987223041 1.73224221183856 0 0 0.0697770307495386 0.0313246786798424 0.0286369328503472 0.0341903498373545 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 1275 8328 30 314 0.977011494252873 0.967344116791988 0.984437266701691 0.0363341819023374 0.0324882012391261 0.0404966777497638 0.132771009059668 0.126044292501508 0.139721299237988 NA NA NA 0 0 0.000442850934432792 NA NA NA NA 986 1774 False True 0 1 1 0 0 0 0 1.6024255523535 1.09420368861351 2.42626988659253 0 0 0.115703308222027 0.0363341819023374 0.0324882012391261 0.0404966777497638 33602 5) Not assoc w R New NotAwR yes 5 +Capreomycin whiB6 c.-75G>A whiB6_c.-75G>A 2 upstream_gene_variant 4338596 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.-75G>T whiB6_c.-75G>T 2 upstream_gene_variant 4338596 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1491 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1002 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-76_-75delAGinsC whiB6_c.-76_-75delAGinsC 2 upstream_gene_variant 4338596 1 12 1 11 2 12 2047 15471 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.999224956403797 0.99864654661041 0.999599461575238 0.142857142857142 0.0177945154831915 0.428129160909698 0.0833333333333333 0.00210759323186022 0.384796165150944 0.0769230769230769 0.00194562849734675 0.360297435267877 0.68708087222987 0.0159548526355573 4.73177525178831 1 619.5 2386 False False 1.25964826575476 0.136849935012166 5.6648428486247 0.00048828125 1.23621345180143e-05 0.00271749449396634 0.999224956403797 0.99864654661041 0.999599461575238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 3 1304 8639 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999652858134691 0.998985842622235 0.999928405279598 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 16.0442452167038 1 503.5 1774 False False 0 0 0 0 0 0 0 2.20833333333333 0.0420336930075031 27.526218938507 0 0 0.00282489773306727 0.999652858134691 0.998985842622235 0.999928405279598 24 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-76_-75delAGinsT whiB6_c.-76_-75delAGinsT 2 upstream_gene_variant 4338596 1 5 0 5 0 6 2049 15477 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 8.24842676385937 1 619.5 2386 False False 0 0 6.41986758323506 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 6 1305 8636 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 7.22930864055075 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 5.62683462374212 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 16 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.-76A>C whiB6_c.-76A>C 2 upstream_gene_variant 4338597 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1516 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1021 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-76delA whiB6_c.-76delA 2 upstream_gene_variant 4338596 1 0 0 0 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1495 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1005 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 16 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-77_-75delGAGinsAA whiB6_c.-77_-75delGAGinsAA 2 upstream_gene_variant 4338596 1 1 0 1 2 2 2047 15481 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.999870826067299 0.999533458063883 0.999984356054634 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 293.618608852166 1 619.5 2386 False False 7.56277479237909 0.547801158574908 104.389914324374 0 0 0.00180046780769359 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 1 1303 8641 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.999884286044897 0.999355453609522 0.999997070380594 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 987 1774 False False 0 0 0 0 0 0 0 13.2632386799693 0.689686563300777 778.308617525017 0 0 0.00282706266083767 0.999884286044897 0.999355453609522 0.999997070380594 19 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-77_-75delGAGinsCA whiB6_c.-77_-75delGAGinsCA 2 upstream_gene_variant 4338596 1 6 0 6 0 15 2049 15468 0 0 0.00179871197794837 0.999031195504747 0.998402606935329 0.999457669301639 0 0 0.218019360910534 0 0 0.4592581264399 0 0 0.218019360910534 0 0 6.4161344469798 1 619.5 2386 False False 0 0 2.10669629306639 0 0 0.00179871197794837 0.999031195504747 0.998402606935329 0.999457669301639 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 14 1305 8628 0 0 0.00282273611850443 0.998380004628558 0.99728341538717 0.999114059339894 0 0 0.231635761650116 0 0 0.4592581264399 0 0 0.231635761650116 0 0 5.62162306990825 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 1.99604026463537 0 0 0.00282273611850443 0.998380004628558 0.99728341538717 0.999114059339894 31 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-78_-75delAGAGinsCGA whiB6_c.-78_-75delAGAGinsCGA 2 upstream_gene_variant 4338596 1 14 0 14 5 25 2044 15458 0.00244021473889702 0.000792791037816739 0.00568538572188254 0.998385325841245 0.997617338903258 0.998954803937918 0.166666666666666 0.0564216964680715 0.347211698834143 0 0 0.231635761650116 0 0 0.137185171530712 0 0 2.28192401594871 0.394714467623256 146 2386 False False 1.51252446183953 0.4516888475537 4.02839503520667 0 0 0.00180310798912163 0.998385325841245 0.997617338903258 0.998954803937918 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 2 12 1303 8630 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.998611432538764 0.997575709681241 0.999282307587457 0.142857142857142 0.0177945154831915 0.428129160909698 0 0 0.521823750104981 0 0 0.264648469397051 0 0 7.23538513205146 1 503.5 1774 False False 0 0 0 0 0 0 0 1.1038628805321 0.119841795339487 4.96678839021618 0 0 0.00282706266083767 0.998611432538764 0.997575709681241 0.999282307587457 78 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-78_-75delAGAGinsGGA whiB6_c.-78_-75delAGAGinsGGA 2 upstream_gene_variant 4338596 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1509 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-78_-75delAGAGinsTGA whiB6_c.-78_-75delAGAGinsTGA 2 upstream_gene_variant 4338596 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 35.2688392655279 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.-78delA whiB6_c.-78delA 2 upstream_gene_variant 4338598 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1496 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-79_-75delTAGAGinsCCGA whiB6_c.-79_-75delTAGAGinsCCGA 2 upstream_gene_variant 4338596 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.-79_-78delTAinsC whiB6_c.-79_-78delTAinsC 2 upstream_gene_variant 4338599 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1505 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1011 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-79T>C whiB6_c.-79T>C 2 upstream_gene_variant 4338600 1 67 4 63 14 68 2035 15415 0.00683260126891166 0.00374033277078387 0.011437395963874 0.995608086288187 0.994435478582681 0.99658794147145 0.170731707317073 0.0966052802579547 0.269836189871082 0.0597014925373134 0.0165044043203047 0.145863231873139 0.0555555555555555 0.0153425371111305 0.136178649312924 0.48094848094848 0.126988601652487 1.2956726380407 0.181285460028035 111 2386 False False 1.55954617719323 0.808472951146985 2.80565684544611 0.00196174595389897 0.00053476031365161 0.00501516553187813 0.995608086288187 0.994435478582681 0.99658794147145 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 12 2 10 5 11 1300 8631 0.00383141762452107 0.00124518543639507 0.00891842567874012 0.998727146493867 0.997723657451287 0.999364430275444 0.3125 0.110169954717117 0.586620636451358 0.166666666666666 0.0208625254600923 0.484137748685967 0.153846153846153 0.0192066719825284 0.454471055676557 1.32784615384615 0.141331541022138 6.24100478858007 0.664335436452088 117 1774 False False 0 0 0 0 0 0 0 3.01783216783216 0.820525844294643 9.44116192502338 0.00153609831029185 0.000186082798055881 0.00553779302237776 0.998727146493867 0.997723657451287 0.999364430275444 39 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.-79T>G whiB6_c.-79T>G 2 upstream_gene_variant 4338600 1 8 0 8 1 13 2048 15470 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999160369437447 0.998564634148971 0.999552858749588 0.0714285714285714 0.00180678065912538 0.338684489931821 0 0 0.369416647552819 0 0 0.24705263800047 0 0 4.42867910065449 0.608198586728208 167 2386 False False 0.5810546875 0.0136690692758468 3.87283897587666 0 0 0.00179958946453767 0.999160369437447 0.998564634148971 0.999552858749588 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 1 9 1304 8633 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.998958574404073 0.998023974495813 0.999523686828456 0.1 0.00252857854446178 0.445016117028195 0 0 0.409616397225003 0 0 0.336267116879942 0 0 4.59885920996055 0.60491231963366 110 1774 False False 0 0 0 0 0 0 0 0.735599863667348 0.0167698879909291 5.31583775548636 0 0 0.00282489773306727 0.998958574404073 0.998023974495813 0.999523686828456 33 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-80_-71delCTAGAGCTCG whiB6_c.-80_-71delCTAGAGCTCG 2 upstream_gene_variant 4338591 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-81_-72delACTAGAGCTC whiB6_c.-81_-72delACTAGAGCTC 2 upstream_gene_variant 4338592 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1463 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 982 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.-81_-74delACTAGAGC whiB6_c.-81_-74delACTAGAGC 2 upstream_gene_variant 4338594 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-81_-78delACTAinsTCC whiB6_c.-81_-78delACTAinsTCC 2 upstream_gene_variant 4338599 1 3 0 3 0 7 2049 15476 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 0 0 0.409616397225003 0 0 0.707598226178713 0 0 0.409616397225003 0 0 18.2933236422411 1 194.5 2386 False False 0 0 5.24430081649792 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 257.143707584236 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 7 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.-81_-80delAC whiB6_c.-81_-80delAC 2 upstream_gene_variant 4338600 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-81A>T whiB6_c.-81A>T 2 upstream_gene_variant 4338602 1 0 0 0 1 3 2048 15480 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999806239100949 0.999433853882399 0.999960040061829 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1536 2386 False False 2.51953125 0.047970285762596 31.379124977949 0 0 0.00179958946453767 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 1 1304 8641 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999884286044897 0.999355453609522 0.999997070380594 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1034 1774 False False 0 0 0 0 0 0 0 6.62653374233128 0.0843535983905244 517.917818294861 0 0 0.00282489773306727 0.999884286044897 0.999355453609522 0.999997070380594 7 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.81T>C whiB6_c.81T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 11.4504880046624 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.0364048825129 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin whiB6 c.-82_-27delCACTAGAGCTCGGAGCTCGCCGAACCGGAGCCGCAGCACCGCTAGGCAGGCAGAGG whiB6_c.-82_-27delCACTAGAGCTCGGAGCTCGCCGAACCGGAGCCGCAGCACCGCTAGGCAGGCAGAGG 2 upstream_gene_variant 4338547 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-82_-75delCACTAGAGinsA whiB6_c.-82_-75delCACTAGAGinsA 2 upstream_gene_variant 4338596 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-82C>T whiB6_c.-82C>T 2 upstream_gene_variant 4338603 NA 0 0 0 15 887 2034 14596 0.00732064421669106 0.00410292854544325 0.0120455873654437 0.942711360847381 0.938934556821593 0.946320736021186 0.0166297117516629 0.00933662683977675 0.0272800466523113 NA NA NA 0 0 0.00415019094841024 NA NA NA NA NA NA False True 0.121353007885118 0.0674714791518629 0.201832668515577 0 0 0.00181196479059598 0.942711360847381 0.938934556821593 0.946320736021186 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 3 249 1302 8393 0.00229885057471264 0.000474329389656033 0.00670338609202181 0.971187225179356 0.967439765621048 0.974612320335401 0.0119047619047619 0.00246180899908975 0.0343946358546431 NA NA NA 0 0 0.0147055780339792 NA NA NA NA NA NA False True 1 1 1 0 0 1 0 0.0776655007125275 0.0158753702945549 0.230204239700962 0 0 0.00282923090943894 0.971187225179356 0.967439765621048 0.974612320335401 3334 Not assoc w R 5) Not assoc w R No change yes 1 +Capreomycin whiB6 c.-84_-79delCGCACT whiB6_c.-84_-79delCGCACT 2 upstream_gene_variant 4338599 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1517 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1022 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-84C>T whiB6_c.-84C>T 2 upstream_gene_variant 4338605 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1549 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.-86C>T whiB6_c.-86C>T 2 upstream_gene_variant 4338607 1 7 0 7 0 8 2049 15475 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 0 0 0.369416647552819 0 0 0.409616397225003 0 0 0.369416647552819 0 0 5.2439619687243 1 619.5 2386 False False 0 0 4.42794679154129 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 7 1305 8635 0 0 0.00282273611850443 0.999190002314279 0.998331811834773 0.999674278877205 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 5.62618317939773 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 4.59639609856608 0 0 0.00282273611850443 0.999190002314279 0.998331811834773 0.999674278877205 3 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.87C>T whiB6_c.87C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 2048 15482 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.99993541303365 0.999640197578315 0.999998364800924 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 7.5595703125 0.096257452000026 590.418198079286 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin whiB6 c.-87delG whiB6_c.-87delG 2 upstream_gene_variant 4338607 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-87G>A whiB6_c.-87G>A 2 upstream_gene_variant 4338608 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1477 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 994 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-88_-87insA whiB6_c.-88_-87insA 2 upstream_gene_variant 4338608 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1511 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1014 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-88delT whiB6_c.-88delT 2 upstream_gene_variant 4338608 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1497 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.-8T>G whiB6_c.-8T>G 2 upstream_gene_variant 4338529 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1499 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1006 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-91C>T whiB6_c.-91C>T 2 upstream_gene_variant 4338612 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1535 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.-93G>C whiB6_c.-93G>C 2 upstream_gene_variant 4338614 1 4 0 4 0 6 2049 15477 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 0 0 0.4592581264399 0 0 0.602364635616474 0 0 0.4592581264399 0 0 11.4490087322799 1 619.5 2386 False False 0 0 6.41986758323506 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 5 1305 8637 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 16.028235350447 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 7.23014561016525 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 17 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-94C>T whiB6_c.-94C>T 2 upstream_gene_variant 4338615 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-96C>G whiB6_c.-96C>G 2 upstream_gene_variant 4338617 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1506 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.96C>T whiB6_c.96C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 40.2367591624089 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin whiB6 c.-97A>C whiB6_c.-97A>C 2 upstream_gene_variant 4338618 NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1483 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.-99_-98insCTGG whiB6_c.-99_-98insCTGG 2 upstream_gene_variant 4338619 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.-99G>T whiB6_c.-99G>T 2 upstream_gene_variant 4338620 1 1 1 0 1 2 2048 15481 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999870826067299 0.999533458063883 0.999984356054634 0.333333333333333 0.00840375865961264 0.905700675949754 1 0.025 1 0.333333333333333 0.00840375865961264 0.905700675949754 Inf 0.193727989655379 Inf 0.11688533941814 107 2386 False False 3.779541015625 0.0640320806562028 72.4657839845296 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 c.-9C>A whiB6_c.-9C>A 2 upstream_gene_variant 4338530 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 c.9C>T whiB6_c.9C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 45 2045 15438 0.00195217179111761 0.00053214923576723 0.00499072666314977 0.997093586514241 0.996112901452612 0.997879276132981 0.0816326530612244 0.0226908806430732 0.19601418347889 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.671035044824775 0.175111464349635 1.84331620796404 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 35 1302 8607 0.00229885057471264 0.000474329389656033 0.00670338609202181 0.995950011571395 0.99437190538543 0.997177462125409 0.0789473684210526 0.0165864758645295 0.213773291180618 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.566622778143515 0.111322055555814 1.80152066914221 NA NA NA NA NA NA 47 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Capreomycin whiB6 deletion whiB6_deletion 2 feature_ablation (see "Genomic_coordinates" sheet) NA 0 0 0 6 35 2043 15448 0.00292825768667642 0.00107535359935202 0.00636260998410225 0.997739456177743 0.996857519632686 0.998424958795015 0.146341463414634 0.0556573637124366 0.291730488017494 NA NA NA 0 0 0.100032435572105 NA NA NA NA 1545 2386 False False 1.29624501783092 0.445074089220281 3.11975364953087 0 0 0.00180398977111688 0.997739456177743 0.996857519632686 0.998424958795015 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 18 1301 8624 0.00306513409961685 0.000835757856895071 0.00782921001204628 0.997917148808146 0.996710187129532 0.998765117784843 0.181818181818181 0.0518672993124368 0.402845783077871 NA NA NA 0 0 0.185301968137852 NA NA NA NA 1041 1774 False False 0 0 0 0 0 0 0 1.47305491502263 0.362040075001217 4.4806146419181 0 0 0.00283140248651778 0.997917148808146 0.996710187129532 0.998765117784843 48 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 LoF whiB6_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 158 4 154 28 298 2021 15185 0.0136652025378233 0.0090991200789196 0.0196898615772795 0.980753084027643 0.978464112294792 0.982858805237306 0.0858895705521472 0.0578315843402581 0.121741382199348 0.0253164556962025 0.00694001852463194 0.063549404735427 0.0132450331125827 0.00362030127021897 0.0335634732071655 0.195158626628196 0.052431055081421 0.510799003876534 5.03155840838923e-05 9 2386 True False 0.705976508406696 0.459914583826867 1.04497359159798 0.0019753086419753 0.000538459167705361 0.00504978482653608 0.980753084027643 0.978464112294792 0.982858805237306 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 80 2 78 15 139 1290 8503 0.0114942528735632 0.00644712218984824 0.0188872590911248 0.983915760240685 0.98103639274791 0.986461783222132 0.0974025974025974 0.0555467862692419 0.155559416535472 0.025 0.00304208616480959 0.0874071559305922 0.0141843971631205 0.00172243615476722 0.050298329586637 0.169012124826078 0.0200946479147028 0.632781841046512 0.00223942675955614 9 1774 False False 0 0 0 0 0 0 0 0.711310021750041 0.386420457173141 1.21918016715319 0.00154798761609907 0.000187523490115852 0.00558056853335384 0.983915760240685 0.98103639274791 0.986461783222132 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Ala25Pro whiB6_p.Ala25Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1485 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Ala25Ser whiB6_p.Ala25Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1480 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Ala49Asp whiB6_p.Ala49Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 2049 15477 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 6.41986758323506 1 619.5 2386 False False 0 0 6.41986758323506 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 1305 8637 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 7.23014561016525 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 7.23014561016525 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 8 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Ala49Val whiB6_p.Ala49Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Ala4Val whiB6_p.Ala4Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Ala55Asp whiB6_p.Ala55Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 293.33332543886 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Ala55Pro whiB6_p.Ala55Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Ala63fs whiB6_p.Ala63fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Ala63Glu whiB6_p.Ala63Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 2049 15477 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 6.41986758323506 1 619.5 2386 False False 0 0 6.41986758323506 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Ala63Thr whiB6_p.Ala63Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 2049 15477 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 6.41986758323506 1 619.5 2386 False False 0 0 6.41986758323506 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 1305 8636 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 5.62683462374212 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 5.62683462374212 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 1 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Ala63Val whiB6_p.Ala63Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Ala66Thr whiB6_p.Ala66Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 22 0 22 17 25 2032 15458 0.00829673011224987 0.00484036444543717 0.013250735092242 0.998385325841245 0.997617338903258 0.998954803937918 0.404761904761904 0.256290925483658 0.567179109279963 0 0 0.154372512815574 0 0 0.137185171530712 0 0 1.39009338459972 0.10133011105713 35 2386 False False 5.17295275590551 2.61616213420147 9.98634976910614 0 0 0.00181374660218478 0.998385325841245 0.997617338903258 0.998954803937918 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 20 0 20 16 23 1289 8619 0.0122605363984674 0.00702375009003458 0.0198341635631025 0.997338579032631 0.99600922195507 0.998312162422675 0.41025641025641 0.255667796886232 0.579001330595147 0 0 0.168433470983085 0 0 0.148185128915224 0 0 1.35646611665921 0.0983870367200332 26 1774 False False 0 0 0 0 0 0 0 4.65153303875602 2.28955145399508 9.22310298121295 0 0 0.00285772384845833 0.997338579032631 0.99600922195507 0.998312162422675 34 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Ala66Val whiB6_p.Ala66Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 6 2049 15477 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 8.24842676385937 1 619.5 2386 False False 0 0 6.41986758323506 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 257.202999238191 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 6 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Ala6Glu whiB6_p.Ala6Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1523 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Ala6Ser whiB6_p.Ala6Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Ala72fs whiB6_p.Ala72fs 2 frameshift (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 8.24895966345574 1 194.5 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 10.0364048825129 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 30 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Ala72Glu whiB6_p.Ala72Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 2048 15480 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999806239100949 0.999433853882399 0.999960040061829 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 18.30693542144 1 619.5 2386 False False 2.51953125 0.047970285762596 31.379124977949 0 0 0.00179958946453767 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 16.0319456706962 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 3 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Ala72Gly whiB6_p.Ala72Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 2 2047 15481 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.999870826067299 0.999533458063883 0.999984356054634 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 293.618608852166 1 619.5 2386 False False 7.56277479237909 0.547801158574908 104.389914324374 0 0 0.00180046780769359 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 2 1303 8640 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.999768572089794 0.999164255486522 0.999971971777513 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 257.59619612607 1 503.5 1774 False False 0 0 0 0 0 0 0 6.63085188027628 0.480082065417988 91.6551467569938 0 0 0.00282706266083767 0.999768572089794 0.999164255486522 0.999971971777513 5 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Ala77fs whiB6_p.Ala77fs 2 frameshift (see "Genomic_coordinates" sheet) 1 4 0 4 1 4 2048 15479 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999741652134599 0.999338660174897 0.999929604559257 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 11.4560814080796 1 619.5 2386 False False 1.8895263671875 0.0383494517213545 19.1050373764475 0 0 0.00179958946453767 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 1304 8640 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999768572089794 0.999164255486522 0.999971971777513 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 35.2958866065447 1 503.5 1774 False False 0 0 0 0 0 0 0 3.31288343558282 0.056110603773561 63.7302235362974 0 0 0.00282489773306727 0.999768572089794 0.999164255486522 0.999971971777513 4 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Ala77Glu whiB6_p.Ala77Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 0 0 0.841886116991581 0 0 0.521823750104981 0 0 40.2289720864225 1 619.5 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1030 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 2 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Ala77Ser whiB6_p.Ala77Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 11 0 11 0 12 2049 15471 0 0 0.00179871197794837 0.999224956403797 0.99864654661041 0.999599461575238 0 0 0.264648469397051 0 0 0.284914152918154 0 0 0.264648469397051 0 0 3.01082325500509 0.628950464321642 177 2386 False False 0 0 2.71972624224414 0 0 0.00179871197794837 0.999224956403797 0.99864654661041 0.999599461575238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 1305 8636 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 5.62683462374212 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 5.62683462374212 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Ala77Val whiB6_p.Ala77Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 85 5 80 12 138 2037 15345 0.00585651537335285 0.00302969927424994 0.0102077845176216 0.991086998643673 0.989478287236885 0.992506879239759 0.08 0.0420202647001723 0.135573890212639 0.0588235294117647 0.0193735588636756 0.131958033954835 0.0349650349650349 0.0114487819691811 0.0797086682500706 0.470821060382916 0.148646640619073 1.14718685768614 0.124798804162552 108 2386 False False 0.655055388358839 0.329831021958964 1.18424596817261 0.00244857982370225 0.000795510318554293 0.00570484345083253 0.991086998643673 0.989478287236885 0.992506879239759 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 21 1 20 2 32 1303 8610 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.996297153436704 0.994776671397899 0.997465918686142 0.0588235294117647 0.00720491743904971 0.196773209335575 0.0476190476190476 0.00120488344836351 0.238159909936821 0.0303030303030303 0.000766912075048109 0.157593972272496 0.330391404451266 0.00796848075196246 2.06936401686965 0.510991113145046 106 1774 False False 0 0 0 0 0 0 0 0.412989255564082 0.0479046623388498 1.62219200965145 0.000766871165644171 1.94153084409271e-05 0.00426525037799214 0.996297153436704 0.994776671397899 0.997465918686142 18 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Ala87Val whiB6_p.Ala87Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 3 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Ala89fs whiB6_p.Ala89fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Ala89Glu whiB6_p.Ala89Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1531 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Ala91Gly whiB6_p.Ala91Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Ala99fs whiB6_p.Ala99fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Ala99Pro whiB6_p.Ala99Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Ala99Val whiB6_p.Ala99Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 17 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Ala9Val whiB6_p.Ala9Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Arg101Cys whiB6_p.Arg101Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 18.2980327465689 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 8 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Arg107Cys whiB6_p.Arg107Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 11 341 2038 15142 0.00536847242557345 0.00268287699664284 0.0095853329613208 0.977975844474585 0.975540010784092 0.980229708290925 0.03125 0.0157010603167465 0.0552259760870795 NA NA NA 0 0 0.0107595260305735 NA NA NA NA NA NA False True 0.239672037734654 0.118319629944294 0.435375564374458 0 0 0.00180841164945371 0.977975844474585 0.975540010784092 0.980229708290925 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 4 79 1301 8563 0.00306513409961685 0.000835757856895071 0.00782921001204628 0.990858597546864 0.988619929450753 0.992756174953557 0.0481927710843373 0.0132850780783847 0.118818417226919 NA NA NA 0 0 0.045621252758611 NA NA NA NA NA NA False True 0 1 1 0 0 1 0 0.333258739625799 0.0884986172439954 0.88986435492931 0 0 0.00283140248651778 0.990858597546864 0.988619929450753 0.992756174953557 484 Not assoc w R 5) Not assoc w R No change yes 1 +Capreomycin whiB6 p.Arg107fs whiB6_p.Arg107fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Arg107Pro whiB6_p.Arg107Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1528 2386 False False Inf 0.193753017505121 Inf 0 0 0.00179958946453767 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Arg110Trp whiB6_p.Arg110Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 10 0 10 0 10 2049 15473 0 0 0.00179871197794837 0.999354130336498 0.998812544515655 0.999690238326549 0 0 0.30849710781876 0 0 0.30849710781876 0 0 0.30849710781876 0 0 3.37173073063401 0.618030833786075 174.5 2386 False False 0 0 3.37173073063401 0 0 0.00179871197794837 0.999354130336498 0.998812544515655 0.999690238326549 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 35.2688392655279 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 4 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Arg17Gly whiB6_p.Arg17Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 1 7 2048 15476 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999547891235548 0.999068706427379 0.999818210125054 0.125 0.0031597235312519 0.526509670875206 0 0 0.4592581264399 0 0 0.409616397225003 0 0 6.42258942477752 1 619.5 2386 False False 1.07952008928571 0.02394099779516 8.40970244475376 0 0 0.00179958946453767 0.999547891235548 0.999068706427379 0.999818210125054 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 7 1305 8635 0 0 0.00282273611850443 0.999190002314279 0.998331811834773 0.999674278877205 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 5.62618317939773 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 4.59639609856608 0 0 0.00282273611850443 0.999190002314279 0.998331811834773 0.999674278877205 29 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Arg17Lys whiB6_p.Arg17Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 10 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Arg17Met whiB6_p.Arg17Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Arg2fs whiB6_p.Arg2fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Arg40Cys whiB6_p.Arg40Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 8.24895966345574 1 194.5 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 35.2688392655279 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 4 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Arg40His whiB6_p.Arg40His 2 missense_variant (see "Genomic_coordinates" sheet) 1 11 0 11 0 15 2049 15468 0 0 0.00179871197794837 0.999031195504747 0.998402606935329 0.999457669301639 0 0 0.218019360910534 0 0 0.284914152918154 0 0 0.218019360910534 0 0 3.01023985855099 0.628971022652202 178 2386 False False 0 0 2.10669629306639 0 0 0.00179871197794837 0.999031195504747 0.998402606935329 0.999457669301639 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 257.173353425001 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 11 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Arg54Gln whiB6_p.Arg54Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 68 2049 15415 0 0 0.00179871197794837 0.995608086288187 0.994435478582681 0.99658794147145 0 0 0.0528030427936397 NA NA NA 0 0 0.0528030427936397 NA NA NA NA NA NA False True 0 0 0.419806475268008 0 0 0.00179871197794837 0.995608086288187 0.994435478582681 0.99658794147145 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 50 1305 8592 0 0 0.00282273611850443 0.99421430224485 0.992379309455309 0.995702783951473 0 0 0.0711217364641976 NA NA NA 0 0 0.0711217364641976 NA NA NA NA NA NA False True 1 1 1 0 0 1 0 0 0 0.504946877290863 0 0 0.00282273611850443 0.99421430224485 0.992379309455309 0.995702783951473 920 Not assoc w R 5) Not assoc w R No change yes 1 +Capreomycin whiB6 p.Arg54Gly whiB6_p.Arg54Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 6 2048 15477 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999612478201898 0.999156720468893 0.999857773477374 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.975 0 0 0.4592581264399 0 0 293.400421651739 1 619.5 2386 False False 1.259521484375 0.0273691036001646 10.3895811388841 0 0 0.00179958946453767 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 7 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Arg54Pro whiB6_p.Arg54Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 7 2049 15476 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 0 0 0.409616397225003 0 0 0.707598226178713 0 0 0.409616397225003 0 0 18.2933236422411 1 194.5 2386 False False 0 0 5.24430081649792 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Arg58Cys whiB6_p.Arg58Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Arg58fs whiB6_p.Arg58fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1512 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1015 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Arg58Gly whiB6_p.Arg58Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Arg58Pro whiB6_p.Arg58Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Arg59Gln whiB6_p.Arg59Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1550 2386 False False Inf 0.193753017505121 Inf 0 0 0.00179958946453767 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Arg59Leu whiB6_p.Arg59Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Arg59Trp whiB6_p.Arg59Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 293.295605628248 1 619.5 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1028 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 7 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Arg64Cys whiB6_p.Arg64Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Arg64fs whiB6_p.Arg64fs 2 frameshift (see "Genomic_coordinates" sheet) 1 5 0 5 0 7 2049 15476 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 0 0 0.409616397225003 0 0 0.521823750104981 0 0 0.409616397225003 0 0 8.24789386425432 1 619.5 2386 False False 0 0 5.24430081649792 0 0 0.00179871197794837 0.999547891235548 0.999068706427379 0.999818210125054 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 35.2688392655279 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 2 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Arg64His whiB6_p.Arg64His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 10 0 2039 15483 0.00488042947779404 0.0023427615854433 0.00895691175610291 1 0.999761774846946 1 1 0.691502892181239 1 NA NA NA NA NA NA NA NA NA NA 1513 2386 False False Inf 17.00043551777 Inf 0 0 0.00180752554043533 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 10 0 1295 8642 0.00766283524904214 0.00368056529467103 0.014046941693024 1 0.999573236258028 1 1 0.691502892181239 1 NA NA NA NA NA NA NA NA NA NA 1017 1774 False False 0 0 0 0 0 0 0 Inf 14.9289570754452 Inf 0 0 0.00284450227820695 1 0.999573236258028 1 2 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Arg64Leu whiB6_p.Arg64Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 2 2048 15481 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999870826067299 0.999533458063883 0.999984356054634 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1466 2386 False False 3.779541015625 0.0640320806562028 72.4657839845296 0 0 0.00179958946453767 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Arg86fs whiB6_p.Arg86fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 5 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Arg86Gln whiB6_p.Arg86Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Arg86Trp whiB6_p.Arg86Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 3 2048 15480 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999806239100949 0.999433853882399 0.999960040061829 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 40.2537890260391 1 619.5 2386 False False 2.51953125 0.047970285762596 31.379124977949 0 0 0.00179958946453767 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 257.202999238191 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 1 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Arg88Gln whiB6_p.Arg88Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Arg88Gly whiB6_p.Arg88Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Arg88Leu whiB6_p.Arg88Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 35.2688392655279 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Arg88Trp whiB6_p.Arg88Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 2 12 2047 15471 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.999224956403797 0.99864654661041 0.999599461575238 0.142857142857142 0.0177945154831915 0.428129160909698 0 0 0.707598226178713 0 0 0.264648469397051 0 0 18.3052408609027 1 619.5 2386 False False 1.25964826575476 0.136849935012166 5.6648428486247 0 0 0.00180046780769359 0.999224956403797 0.99864654661041 0.999599461575238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 2 9 1303 8633 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.998958574404073 0.998023974495813 0.999523686828456 0.181818181818181 0.0228311982999596 0.517755852360172 0 0 0.707598226178713 0 0 0.336267116879942 0 0 16.0454155919008 1 503.5 1774 False False 0 0 0 0 0 0 0 1.47232881384838 0.154604541408076 7.12417170347034 0 0 0.00282706266083767 0.998958574404073 0.998023974495813 0.999523686828456 28 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Arg96Pro whiB6_p.Arg96Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Arg96* whiB6_p.Arg96* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 1 2 2048 15481 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999870826067299 0.999533458063883 0.999984356054634 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1514 2386 False False 3.779541015625 0.0640320806562028 72.4657839845296 0 0 0.00179958946453767 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1018 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 9 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Asn102Asp whiB6_p.Asn102Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 6 2049 15477 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 8.24842676385937 1 619.5 2386 False False 0 0 6.41986758323506 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 16.0300905104715 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 7 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Asn102fs whiB6_p.Asn102fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1484 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Asp108fs whiB6_p.Asp108fs 2 frameshift (see "Genomic_coordinates" sheet) 1 4 0 4 3 6 2046 15477 0.00146412884333821 0.000302040401839334 0.00427278776332334 0.999612478201898 0.999156720468893 0.999857773477374 0.333333333333333 0.0748546314196918 0.700704943791459 0 0 0.602364635616474 0 0 0.4592581264399 0 0 11.4658031821979 1 619.5 2386 False False 3.78225806451612 0.611520207331762 17.7156682134793 0 0 0.00180134700867096 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 2 1303 8640 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.999768572089794 0.999164255486522 0.999971971777513 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 998 1774 False False 0 0 0 0 0 0 0 6.63085188027628 0.480082065417988 91.6551467569938 0 0 0.00282706266083767 0.999768572089794 0.999164255486522 0.999971971777513 3 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Asp37Gly whiB6_p.Asp37Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 1 8 2048 15475 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999483304269198 0.998982158652985 0.999776901906193 0.111111111111111 0.00280913674659921 0.482496514917337 0 0 0.409616397225003 0 0 0.369416647552819 0 0 5.24652426030038 1 619.5 2386 False False 0.94451904296875 0.021275762868979 7.05211630192235 0 0 0.00179958946453767 0.999483304269198 0.998982158652985 0.999776901906193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Asp39fs whiB6_p.Asp39fs 2 frameshift (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 2048 15480 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999806239100949 0.999433853882399 0.999960040061829 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 18.30693542144 1 619.5 2386 False False 2.51953125 0.047970285762596 31.379124977949 0 0 0.00179958946453767 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 6 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Asp39Gly whiB6_p.Asp39Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Asp46Ala whiB6_p.Asp46Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 8 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Asp46fs whiB6_p.Asp46fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Asp46Glu whiB6_p.Asp46Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 18.2968554679321 1 619.5 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Asp46Gly whiB6_p.Asp46Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 3 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Asp46His whiB6_p.Asp46His 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 40.2315677803598 1 619.5 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1036 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Asp47fs whiB6_p.Asp47fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Asp47Gly whiB6_p.Asp47Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1537 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Asp65Ala whiB6_p.Asp65Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 2048 15482 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.99993541303365 0.999640197578315 0.999998364800924 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 7.5595703125 0.096257452000026 590.418198079286 0.220090832740563 119.5 2386 False False 7.5595703125 0.096257452000026 590.418198079286 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 1304 8641 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999884286044897 0.999355453609522 0.999997070380594 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 6.62653374233128 0.0843535983905244 517.917818294861 0.245189914752491 93.5 1774 False False 0 0 0 0 0 0 0 6.62653374233128 0.0843535983905244 517.917818294861 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Asp65fs whiB6_p.Asp65fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Asp65Gly whiB6_p.Asp65Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1510 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Asp65Tyr whiB6_p.Asp65Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 3 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Cys12Ser whiB6_p.Cys12Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 1 4 2 8 2047 15475 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.999483304269198 0.998982158652985 0.999776901906193 0.2 0.0252107263268333 0.556095462307641 0.2 0.00505076337946806 0.716417936118089 0.111111111111111 0.00280913674659921 0.482496514917337 1.88996091841719 0.0383582622540628 19.1094361697974 0.462790384147113 149 2386 False False 1.88996091841719 0.195371049431526 9.48109495396585 0.00048828125 1.23621345180143e-05 0.00271749449396634 0.999483304269198 0.998982158652985 0.999776901906193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 1 8 1304 8634 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999074288359176 0.998176798225858 0.999600261389848 0.111111111111111 0.00280913674659921 0.482496514917337 0 0 0.602364635616474 0 0 0.369416647552819 0 0 10.0394567237443 1 503.5 1774 False False 0 0 0 0 0 0 0 0.827645705521472 0.0186379987589414 6.18187193560828 0 0 0.00282489773306727 0.999074288359176 0.998176798225858 0.999600261389848 6 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Cys34Arg whiB6_p.Cys34Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1478 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Cys34Trp whiB6_p.Cys34Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Cys34Tyr whiB6_p.Cys34Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 11.4504880046624 1 619.5 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Cys53Arg whiB6_p.Cys53Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 30 1 29 3 33 2046 15450 0.00146412884333821 0.000302040401839334 0.00427278776332334 0.997868630110443 0.997008054406869 0.998532422825367 0.0833333333333333 0.0175264959239346 0.224689760556973 0.0333333333333333 0.000843570926630479 0.172169455633412 0.0294117647058823 0.00074436423469026 0.153267669560317 0.260390332692891 0.0063756871319979 1.57241076170514 0.249439442310384 132 2386 False False 0.686483604372167 0.134591373632332 2.19150852495999 0.000488519785051294 1.23681736279651e-05 0.00271882056160135 0.997868630110443 0.997008054406869 0.998532422825367 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 18 0 18 1 20 1304 8622 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.99768572089794 0.996428035548426 0.998585822914007 0.0476190476190476 0.00120488344836351 0.238159909936821 0 0 0.185301968137852 0 0 0.168433470983085 0 0 1.50620760504782 0.155828940029861 86 1774 False False 0 0 0 0 0 0 0 0.330598159509202 0.00797346945283699 2.07065587795154 0 0 0.00282489773306727 0.99768572089794 0.996428035548426 0.998585822914007 90 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Cys53fs whiB6_p.Cys53fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 40.2341634723554 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 35.2688392655279 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 1 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Cys53Gly whiB6_p.Cys53Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 21 0 21 1 27 2048 15456 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.998256151908544 0.997463799190087 0.998850488356206 0.0357142857142857 0.000903798755658059 0.183477597544623 0 0 0.161097615219079 0 0 0.127702867615432 0 0 1.45064489757258 0.163266478633505 110 2386 False False 0.279513888888888 0.00682701185420005 1.69785809346147 0 0 0.00179958946453767 0.998256151908544 0.997463799190087 0.998850488356206 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 12 0 12 0 13 1305 8629 0 0 0.00282273611850443 0.998495718583661 0.997429006709305 0.999198798037271 0 0 0.24705263800047 0 0 0.264648469397051 0 0 0.24705263800047 0 0 2.38304506458805 0.386223311507893 100 1774 False False 0 0 0 0 0 0 0 0 0 2.17279669430301 0 0 0.00282273611850443 0.998495718583661 0.997429006709305 0.999198798037271 36 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Cys53Phe whiB6_p.Cys53Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 293.33332543886 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Cys53Ser whiB6_p.Cys53Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1472 2386 False False Inf 0.193753017505121 Inf 0 0 0.00179958946453767 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 991 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0 0 0.00282489773306727 1 0.999573236258028 1 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Cys53* whiB6_p.Cys53* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Cys53Tyr whiB6_p.Cys53Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1527 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Cys56fs whiB6_p.Cys56fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Cys56Gly whiB6_p.Cys56Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1492 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Cys62Arg whiB6_p.Cys62Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Cys62fs whiB6_p.Cys62fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 293.33332543886 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Cys62Gly whiB6_p.Cys62Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Cys62Ser whiB6_p.Cys62Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 293.33332543886 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Cys62* whiB6_p.Cys62* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1546 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1042 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Cys62Tyr whiB6_p.Cys62Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1518 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Gln114fs whiB6_p.Gln114fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 35.2688392655279 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 3 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Gln36* whiB6_p.Gln36* 2 stop_gained (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 11.4504880046624 1 619.5 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 16.0319456706962 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 3 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Gln94Glu whiB6_p.Gln94Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 10 2049 15473 0 0 0.00179871197794837 0.999354130336498 0.998812544515655 0.999690238326549 0 0 0.30849710781876 0 0 0.841886116991581 0 0 0.30849710781876 0 0 40.2159935876333 1 619.5 2386 False False 0 0 3.37173073063401 0 0 0.00179871197794837 0.999354130336498 0.998812544515655 0.999690238326549 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 8 1305 8634 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 0 0 0.369416647552819 0 0 0.975 0 0 0.369416647552819 0 0 257.025123945417 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 3.88085962593317 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 891 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Gln94* whiB6_p.Gln94* 2 stop_gained (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 40.2341634723554 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 983 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Glu100fs whiB6_p.Glu100fs 2 frameshift (see "Genomic_coordinates" sheet) 1 7 0 7 0 12 2049 15471 0 0 0.00179871197794837 0.999224956403797 0.99864654661041 0.999599461575238 0 0 0.264648469397051 0 0 0.409616397225003 0 0 0.264648469397051 0 0 5.24260657776553 1 1029.5 2386 False False 0 0 2.71972624224414 0 0 0.00179871197794837 0.999224956403797 0.99864654661041 0.999599461575238 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 20 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Glu28fs whiB6_p.Glu28fs 2 frameshift (see "Genomic_coordinates" sheet) 1 12 0 12 0 18 2049 15465 0 0 0.00179871197794837 0.998837434605696 0.998163265407594 0.999310849114122 0 0 0.185301968137852 0 0 0.264648469397051 0 0 0.185301968137852 0 0 2.71867178260819 0.382288908547738 140 2386 False False 0 0 1.71827245098949 0 0 0.00179871197794837 0.998837434605696 0.998163265407594 0.999310849114122 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 0 10 1305 8632 0 0 0.00282273611850443 0.99884286044897 0.997873012135272 0.999444971558315 0 0 0.30849710781876 0 0 0.369416647552819 0 0 0.30849710781876 0 0 3.87996072556899 0.607693402484101 112 1774 False False 0 0 0 0 0 0 0 0 0 2.9548002607889 0 0 0.00282273611850443 0.99884286044897 0.997873012135272 0.999444971558315 14 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Glu28Gln whiB6_p.Glu28Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 18.2980327465689 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Glu28Lys whiB6_p.Glu28Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1538 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1035 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 6 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Glu48fs whiB6_p.Glu48fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Glu68* whiB6_p.Glu68* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Glu73fs whiB6_p.Glu73fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Glu73* whiB6_p.Glu73* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1487 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 999 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Glu83Lys whiB6_p.Glu83Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Glu8Ala whiB6_p.Glu8Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Glu8Asp whiB6_p.Glu8Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 35.2688392655279 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 43 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Glu8Gly whiB6_p.Glu8Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 8 2049 15475 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1547 2386 False False 0 0 4.42794679154129 0 0 0.00179871197794837 0.999483304269198 0.998982158652985 0.999776901906193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 8 1305 8634 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1043 1774 False False 0 0 0 0 0 0 0 0 0 3.88085962593317 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 4 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Glu8Lys whiB6_p.Glu8Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1515 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1019 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 34 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Glu8Val whiB6_p.Glu8Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Gly32Ser whiB6_p.Gly32Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Gly74Arg whiB6_p.Gly74Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Gly78fs whiB6_p.Gly78fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Gly78Glu whiB6_p.Gly78Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1539 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1037 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Gly78Val whiB6_p.Gly78Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 40.2341634723554 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Gly85Arg whiB6_p.Gly85Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Gly85Asp whiB6_p.Gly85Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 40.2341634723554 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1000 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 7 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Gly85fs whiB6_p.Gly85fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 4 5 2045 15478 0.00195217179111761 0.00053214923576723 0.00499072666314977 0.999677065168249 0.999246540104889 0.9998951358908 0.444444444444444 0.136995662265166 0.787991493221131 0 0 0.975 0 0 0.521823750104981 0 0 293.847758328775 1 194.5 2386 False False 6.05496332518337 1.20025687575651 28.1731568275793 0 0 0.00180222706872706 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 4 5 1301 8637 0.00306513409961685 0.000835757856895071 0.00782921001204628 0.999421430224485 0.99865033199523 0.999812114132187 0.444444444444444 0.136995662265166 0.787991493221131 0 0 0.975 0 0 0.521823750104981 0 0 257.901388285666 1 503.5 1774 False False 0 0 0 0 0 0 0 5.31099154496541 1.05216858758495 24.7018089616901 0 0 0.00283140248651778 0.999421430224485 0.99865033199523 0.999812114132187 1 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Gly85Ser whiB6_p.Gly85Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 13 2049 15470 0 0 0.00179871197794837 0.999160369437447 0.998564634148971 0.999552858749588 0 0 0.24705263800047 NA NA NA 0 0 0.24705263800047 NA NA NA NA 1542 2386 False False 0 0 2.47945785793639 0 0 0.00179871197794837 0.999160369437447 0.998564634148971 0.999552858749588 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1039 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 51 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Gly85Val whiB6_p.Gly85Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Gly93fs whiB6_p.Gly93fs 2 frameshift (see "Genomic_coordinates" sheet) 1 4 0 4 0 6 2049 15477 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 0 0 0.4592581264399 0 0 0.602364635616474 0 0 0.4592581264399 0 0 11.4490087322799 1 619.5 2386 False False 0 0 6.41986758323506 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 12 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.His109Gln whiB6_p.His109Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1500 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1008 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.His109Tyr whiB6_p.His109Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Ile81Thr whiB6_p.Ile81Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1548 2386 False False Inf 0.193753017505121 Inf 0 0 0.00179958946453767 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1044 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0 0 0.00282489773306727 1 0.999573236258028 1 1 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Leu26fs whiB6_p.Leu26fs 2 frameshift (see "Genomic_coordinates" sheet) 1 4 0 4 0 6 2049 15477 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 0 0 0.4592581264399 0 0 0.602364635616474 0 0 0.4592581264399 0 0 11.4490087322799 1 619.5 2386 False False 0 0 6.41986758323506 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 4 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Leu31fs whiB6_p.Leu31fs 2 frameshift (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 8.24895966345574 1 194.5 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 35.2688392655279 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 4 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Leu52fs whiB6_p.Leu52fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 293.33332543886 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Leu52Gln whiB6_p.Leu52Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 10 0 10 0 14 2049 15469 0 0 0.00179871197794837 0.999095782471097 0.998483341560662 0.999505570487652 0 0 0.231635761650116 0 0 0.30849710781876 0 0 0.231635761650116 0 0 3.37085915710947 0.618047503956119 176 2386 False False 0 0 2.27797115095248 0 0 0.00179871197794837 0.999095782471097 0.998483341560662 0.999505570487652 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 6 1305 8636 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 7.22930864055075 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 5.62683462374212 0 0 0.00282273611850443 0.999305716269382 0.998489453757575 0.999745168847445 24 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Leu52Pro whiB6_p.Leu52Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 2049 15479 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 18.2968554679321 1 619.5 2386 False False 0 0 11.4504880046624 0 0 0.00179871197794837 0.999741652134599 0.999338660174897 0.999929604559257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Leu61fs whiB6_p.Leu61fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1473 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Leu75fs whiB6_p.Leu75fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1498 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Leu75Gln whiB6_p.Leu75Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 3 2 2046 15481 0.00146412884333821 0.000302040401839334 0.00427278776332334 0.999870826067299 0.999533458063883 0.999984356054634 0.6 0.146632799634673 0.947255049473683 0.5 0.012579117093425 0.987420882906574 0.333333333333333 0.00840375865961264 0.905700675949754 7.56647116324535 0.0963452762256367 590.954229090991 0.219924625655876 113 2386 False False 11.349706744868 1.29904134176337 136.091774938834 0.000488519785051294 1.23681736279651e-05 0.00271882056160135 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 3 2 1302 8640 0.00229885057471264 0.000474329389656033 0.00670338609202181 0.999768572089794 0.999164255486522 0.999971971777513 0.6 0.146632799634673 0.947255049473683 0.5 0.012579117093425 0.987420882906574 0.333333333333333 0.00840375865961264 0.905700675949754 6.63594470046082 0.0844732980828103 518.649870550392 0.244909176190043 90 1774 False False 0 0 0 0 0 0 0 9.95391705069124 1.13862909485562 119.306388654823 0.00076745970836531 1.94302087631205e-05 0.00426851804482144 0.999768572089794 0.999164255486522 0.999971971777513 25 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Leu75Met whiB6_p.Leu75Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1532 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1031 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Leu92Ser whiB6_p.Leu92Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 16 5 2033 15478 0.00780868716447047 0.00446973512241491 0.0126499212167889 0.999677065168249 0.999246540104889 0.9998951358908 0.761904761904761 0.528340172345378 0.917824124406977 0 0 0.841886116991581 0 0 0.521823750104981 0 0 40.5452441805805 1 619.5 2386 False False 24.362813575996 8.51396211754582 85.1228170071719 0 0 0.00181285525856573 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1304 8642 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 1 0.999573236258028 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 995 1774 False False 0 0 0 0 0 0 0 Inf 0.169800530161289 Inf 0 0 0.00282489773306727 1 0.999573236258028 1 4 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Leu95Ala whiB6_p.Leu95Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Leu95Arg whiB6_p.Leu95Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 4 5 2045 15478 0.00195217179111761 0.00053214923576723 0.00499072666314977 0.999677065168249 0.999246540104889 0.9998951358908 0.444444444444444 0.136995662265166 0.787991493221131 0 0 0.841886116991581 0 0 0.521823750104981 0 0 40.3075787780449 1 619.5 2386 False False 6.05496332518337 1.20025687575651 28.1731568275793 0 0 0.00180222706872706 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 257.143707584236 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 6 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Leu95del whiB6_p.Leu95del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Leu95Pro whiB6_p.Leu95Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 18.2980327465689 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 35.2688392655279 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 3 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Leu98Arg whiB6_p.Leu98Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Leu98fs whiB6_p.Leu98fs 2 frameshift (see "Genomic_coordinates" sheet) 1 18 0 18 0 18 2049 15465 0 0 0.00179871197794837 0.998837434605696 0.998163265407594 0.999310849114122 0 0 0.185301968137852 0 0 0.185301968137852 0 0 0.185301968137852 0 0 1.71827245098949 0.257453969682433 133 2386 False False 0 0 1.71827245098949 0 0 0.00179871197794837 0.998837434605696 0.998163265407594 0.999310849114122 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 16 0 16 0 16 1305 8626 0 0 0.00282273611850443 0.998148576718352 0.996995141231936 0.998941392909931 0 0 0.205907214207822 0 0 0.205907214207822 0 0 0.205907214207822 0 0 1.71646889297801 0.25348410775634 98.5 1774 False False 0 0 0 0 0 0 0 0 0 1.71646889297801 0 0 0.00282273611850443 0.998148576718352 0.996995141231936 0.998941392909931 8 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Leu98Pro whiB6_p.Leu98Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 3 2048 15480 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999806239100949 0.999433853882399 0.999960040061829 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 40.2537890260391 1 619.5 2386 False False 2.51953125 0.047970285762596 31.379124977949 0 0 0.00179958946453767 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 1304 8640 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999768572089794 0.999164255486522 0.999971971777513 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 35.2958866065447 1 503.5 1774 False False 0 0 0 0 0 0 0 3.31288343558282 0.056110603773561 63.7302235362974 0 0 0.00282489773306727 0.999768572089794 0.999164255486522 0.999971971777513 1 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Leu98Val whiB6_p.Leu98Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Lys50Asn whiB6_p.Lys50Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1467 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 988 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 5 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Lys50Gln whiB6_p.Lys50Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Lys50Glu whiB6_p.Lys50Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Lys50* whiB6_p.Lys50* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Lys50Thr whiB6_p.Lys50Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Met1? whiB6_p.Met1? 2 start_lost (see "Genomic_coordinates" sheet) 1 3 0 3 1 58 2048 15425 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.996253955951689 0.995160025992637 0.997154279878631 0.0169491525423728 0.000429023332723594 0.0908559328866492 0 0 0.707598226178713 0 0 0.0616210089039198 0 0 18.242155297938 1 619.5 2386 False False 0.129857556573275 0.00323480598863659 0.753628556288327 0 0 0.00179958946453767 0.996253955951689 0.995160025992637 0.997154279878631 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 29 1305 8613 0 0 0.00282273611850443 0.996644295302013 0.995184176294224 0.997751515158685 0 0 0.119444869069502 0 0 0.707598226178713 0 0 0.119444869069502 0 0 15.9837115702778 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 0.896669804310873 0 0 0.00282273611850443 0.996644295302013 0.995184176294224 0.997751515158685 239 3) Uncertain significance New Uncertain no 1 +Capreomycin whiB6 p.Met21Ile whiB6_p.Met21Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 6 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Met21Thr whiB6_p.Met21Thr 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 6 2048 15477 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999612478201898 0.999156720468893 0.999857773477374 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1479 2386 False False 1.259521484375 0.0273691036001646 10.3895811388841 0 0 0.00179958946453767 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 17 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Phe5Ser whiB6_p.Phe5Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Phe90Leu whiB6_p.Phe90Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Phe90Ser whiB6_p.Phe90Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 1 2048 15482 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.99993541303365 0.999640197578315 0.999998364800924 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1551 2386 False False 7.5595703125 0.096257452000026 590.418198079286 0 0 0.00179958946453767 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 1 1304 8641 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999884286044897 0.999355453609522 0.999997070380594 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1045 1774 False False 0 0 0 0 0 0 0 6.62653374233128 0.0843535983905244 517.917818294861 0 0 0.00282489773306727 0.999884286044897 0.999355453609522 0.999997070380594 5 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Phe90Val whiB6_p.Phe90Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Pro105fs whiB6_p.Pro105fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 35.2688392655279 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 4 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Pro105Gln whiB6_p.Pro105Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 40.2341634723554 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Pro30Leu whiB6_p.Pro30Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1533 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1032 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Pro38Ala whiB6_p.Pro38Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 22 1 21 10 26 2039 15457 0.00488042947779404 0.0023427615854433 0.00895691175610291 0.998320738874895 0.997540454635474 0.998902766748277 0.277777777777777 0.142002447263402 0.451861145067839 0.0454545454545454 0.00115014752657357 0.228444397667633 0.037037037037037 0.000937257091944708 0.189705617413044 0.360984609635909 0.00872787360468727 2.24703962834544 0.50501457471566 153 2386 False False 2.91564492398234 1.25262192711604 6.25964942723807 0.000490196078431372 1.24106131760805e-05 0.00272813939610212 0.998320738874895 0.997540454635474 0.998902766748277 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 1 5 3 7 1302 8635 0.00229885057471264 0.000474329389656033 0.00670338609202181 0.999190002314279 0.998331811834773 0.999674278877205 0.3 0.0667395111777345 0.652452850059997 0.166666666666666 0.00421074451448947 0.641234578997674 0.125 0.0031597235312519 0.526509670875206 1.32642089093702 0.028022886567737 11.8669679588364 0.569593350836669 107 1774 False False 0 0 0 0 0 0 0 2.84233048057932 0.473617252056827 12.4633504559752 0.00076745970836531 1.94302087631205e-05 0.00426851804482144 0.999190002314279 0.998331811834773 0.999674278877205 3 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Pro38fs whiB6_p.Pro38fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1488 2386 False False Inf 0.193753017505121 Inf 0 0 0.00179958946453767 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Pro38Leu whiB6_p.Pro38Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 18 3 15 7 23 2042 15460 0.00341630063445583 0.00137459927358868 0.00702614099723331 0.998514499773945 0.997771848972111 0.999058094518622 0.233333333333333 0.0993378649580198 0.422836522978219 0.166666666666666 0.0357850831215746 0.414177491394774 0.115384615384615 0.0244580753179622 0.301540400107567 1.51420176297747 0.280737811925879 5.35932512638308 0.459023822114319 147 2386 False False 2.30422007409615 0.833910099194818 5.55459830113234 0.00146699266503667 0.000302631389607176 0.00428113350742775 0.998514499773945 0.997771848972111 0.999058094518622 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 257.173353425001 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 38 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Pro38Ser whiB6_p.Pro38Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 40.2367591624089 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 4 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Pro45Ser whiB6_p.Pro45Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Pro82Leu whiB6_p.Pro82Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 18.2980327465689 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 35.2688392655279 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 2 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Ser112fs whiB6_p.Ser112fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1501 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Ser112Phe whiB6_p.Ser112Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Ser115Ala whiB6_p.Ser115Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 11 2049 15472 0 0 0.00179871197794837 0.999289543370148 0.998729153244051 0.999645290955256 0 0 0.284914152918154 0 0 0.409616397225003 0 0 0.284914152918154 0 0 5.24294542548486 1 619.5 2386 False False 0 0 3.01101772028239 0 0 0.00179871197794837 0.999289543370148 0.998729153244051 0.999645290955256 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 35.2647591017504 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 6 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Ser115fs whiB6_p.Ser115fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Ser84Leu whiB6_p.Ser84Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Ser97fs whiB6_p.Ser97fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 2048 15483 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.193753017505121 Inf 0.116872005475701 73 2386 False False Inf 0.193753017505121 Inf 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 1 0.999761774846946 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Ser97Pro whiB6_p.Ser97Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 24 0 24 1 32 2048 15451 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.997933217076794 0.997083560765107 0.998585905717672 0.0303030303030303 0.000766912075048109 0.157593972272496 0 0 0.142473597722525 0 0 0.108881160679352 0 0 1.25469622386793 0.104027266877861 36 2386 False False 0.235763549804687 0.00579093034668053 1.41306435022202 0 0 0.00179958946453767 0.997933217076794 0.997083560765107 0.998585905717672 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 1 7 1304 8635 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999190002314279 0.998331811834773 0.999674278877205 0.125 0.0031597235312519 0.526509670875206 0 0 0.521823750104981 0 0 0.409616397225003 0 0 7.23401977844801 1 503.5 1774 False False 0 0 0 0 0 0 0 0.945990359333917 0.0209738740409183 7.37396279411377 0 0 0.00282489773306727 0.999190002314279 0.998331811834773 0.999674278877205 6 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Thr10Ala whiB6_p.Thr10Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Thr11Ala whiB6_p.Thr11Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1489 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Thr11Pro whiB6_p.Thr11Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Thr24fs whiB6_p.Thr24fs 2 frameshift (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 18.2980327465689 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 35.2688392655279 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Thr35Pro whiB6_p.Thr35Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Thr42Met whiB6_p.Thr42Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Thr43Ala whiB6_p.Thr43Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 2 2047 15481 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.999870826067299 0.999533458063883 0.999984356054634 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1543 2386 False False 7.56277479237909 0.547801158574908 104.389914324374 0 0 0.00180046780769359 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Thr43Pro whiB6_p.Thr43Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 293.33332543886 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Thr44Ile whiB6_p.Thr44Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 293.314465539138 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 6 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Thr44Pro whiB6_p.Thr44Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 293.33332543886 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 257.202999238191 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 28 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Thr51Ala whiB6_p.Thr51Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Thr51Pro whiB6_p.Thr51Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 281 909 1768 14574 0.137140068326012 0.122528551423187 0.152798040306594 0.941290447587676 0.93747161262065 0.944942412931828 0.236134453781512 0.212260121590981 0.261320103087225 NA NA NA 0 0 0.00404994995947982 NA NA NA NA NA NA False True 2.54823185938503 2.20117391606267 2.94315701634551 0 0 0.00208429511343207 0.941290447587676 0.93747161262065 0.944942412931828 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 256 866 1049 7776 0.196168582375478 0.174944154468104 0.218770679391527 0.899791714880814 0.893267557840604 0.906044895790983 0.228163992869875 0.203902174457705 0.253859846214453 NA NA NA 0 0 0.00425061649216176 NA NA NA NA NA NA False True 0 1 1 0 0 1 0 2.19130503701975 1.87132203996419 2.55992476151952 0 0 0.00351039175720678 0.899791714880814 0.893267557840604 0.906044895790983 769 Not assoc w R 5) Not assoc w R No change yes 1 +Capreomycin whiB6 p.Trp16Arg whiB6_p.Trp16Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Trp16Cys whiB6_p.Trp16Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 1 3 2048 15480 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999806239100949 0.999433853882399 0.999960040061829 0.25 0.00630946320970987 0.805879550316756 0.333333333333333 0.00840375865961264 0.905700675949754 0.25 0.00630946320970987 0.805879550316756 3.779296875 0.0640279444830569 72.461063482786 0.311266380021274 137 2386 False False 2.51953125 0.047970285762596 31.379124977949 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 1304 8641 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999884286044897 0.999355453609522 0.999997070380594 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 6.62653374233128 0.0843535983905244 517.917818294861 0.245189914752491 93.5 1774 False False 0 0 0 0 0 0 0 6.62653374233128 0.0843535983905244 517.917818294861 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Trp16Ser whiB6_p.Trp16Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1481 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 996 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 3 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Trp16* whiB6_p.Trp16* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1525 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Trp41Cys whiB6_p.Trp41Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 2048 15481 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999870826067299 0.999533458063883 0.999984356054634 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 293.475897815623 1 619.5 2386 False False 3.779541015625 0.0640320806562028 72.4657839845296 0 0 0.00179958946453767 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Trp41fs whiB6_p.Trp41fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 1 3 2048 15480 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.999806239100949 0.999433853882399 0.999960040061829 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 40.2537890260391 1 619.5 2386 False False 2.51953125 0.047970285762596 31.379124977949 0 0 0.00179958946453767 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 1305 8639 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 35.2647591017504 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 16.0319456706962 0 0 0.00282273611850443 0.999652858134691 0.998985842622235 0.999928405279598 NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Trp41* whiB6_p.Trp41* 2 stop_gained (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 18.2980327465689 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Trp60Arg whiB6_p.Trp60Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 293.33332543886 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1020 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Trp60fs whiB6_p.Trp60fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Trp60* whiB6_p.Trp60* 2 stop_gained (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 40.2341634723554 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Trp76Gly whiB6_p.Trp76Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 18.2956781909983 1 619.5 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 3 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Trp76Ser whiB6_p.Trp76Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Trp76* whiB6_p.Trp76* 2 stop_gained (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 2049 15480 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 18.2980327465689 1 619.5 2386 False False 0 0 18.2980327465689 0 0 0.00179871197794837 0.999806239100949 0.999433853882399 0.999960040061829 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 35.2688392655279 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 2 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Tyr104fs whiB6_p.Tyr104fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 2048 15482 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.99993541303365 0.999640197578315 0.999998364800924 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 7.5595703125 0.096257452000026 590.418198079286 0.220090832740563 119.5 2386 False False 7.5595703125 0.096257452000026 590.418198079286 0.000488042947779404 1.23561013027172e-05 0.00271616971924283 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 1304 8641 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999884286044897 0.999355453609522 0.999997070380594 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 6.62653374233128 0.0843535983905244 517.917818294861 0.245189914752491 93.5 1774 False False 0 0 0 0 0 0 0 6.62653374233128 0.0843535983905244 517.917818294861 0.000766283524904214 1.94004309542551e-05 0.00426198771030521 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Tyr104His whiB6_p.Tyr104His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Tyr27fs whiB6_p.Tyr27fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Tyr27Ser whiB6_p.Tyr27Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 2 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Tyr27* whiB6_p.Tyr27* 2 stop_gained (see "Genomic_coordinates" sheet) 1 12 0 12 0 22 2049 15461 0 0 0.00179871197794837 0.998579086740295 0.997849505931622 0.999109313702287 0 0 0.154372512815574 0 0 0.264648469397051 0 0 0.154372512815574 0 0 2.71796880896123 0.382285977898533 139 2386 False False 0 0 1.378819480599 0 0 0.00179871197794837 0.998579086740295 0.997849505931622 0.999109313702287 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 5 1305 8637 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 16.028235350447 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 7.23014561016525 0 0 0.00282273611850443 0.999421430224485 0.99865033199523 0.999812114132187 38 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Tyr3Cys whiB6_p.Tyr3Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 9 2049 15474 0 0 0.00179871197794837 0.999418717302848 0.998896832459985 0.999734167184357 0 0 0.336267116879942 0 0 0.602364635616474 0 0 0.336267116879942 0 0 11.4467898236736 1 619.5 2386 False False 0 0 3.82923083971975 0 0 0.00179871197794837 0.999418717302848 0.998896832459985 0.999734167184357 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 8 1305 8634 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 0 0 0.369416647552819 0 0 0.707598226178713 0 0 0.369416647552819 0 0 16.0226698715761 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 3.88085962593317 0 0 0.00282273611850443 0.999074288359176 0.998176798225858 0.999600261389848 6 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Val106fs whiB6_p.Val106fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Val106Met whiB6_p.Val106Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Val111Ala whiB6_p.Val111Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Val23Ala whiB6_p.Val23Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 2049 15481 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 293.33332543886 1 619.5 2386 False False 0 0 40.2367591624089 0 0 0.00179871197794837 0.999870826067299 0.999533458063883 0.999984356054634 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 984 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Val23Gly whiB6_p.Val23Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1474 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 992 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 23 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Val33Asp whiB6_p.Val33Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1502 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1009 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Val33Gly whiB6_p.Val33Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1526 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1305 8638 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1027 1774 False False 0 0 0 0 0 0 0 0 0 10.0364048825129 0 0 0.00282273611850443 0.999537144179588 0.998815333169806 0.999873873427139 6 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Val67fs whiB6_p.Val67fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 5 2049 15478 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 0 0 0.521823750104981 0 0 0.841886116991581 0 0 0.521823750104981 0 0 40.2289720864225 1 619.5 2386 False False 0 0 8.24895966345574 0 0 0.00179871197794837 0.999677065168249 0.999246540104889 0.9998951358908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Capreomycin whiB6 p.Val79Ala whiB6_p.Val79Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 10 1 9 2 11 2047 15472 0.000976085895558809 0.000118230396782607 0.00352146535805941 0.999289543370148 0.998729153244051 0.999645290955256 0.153846153846153 0.0192066719825284 0.454471055676557 0.1 0.00252857854446178 0.445016117028195 0.0833333333333333 0.00210759323186022 0.384796165150944 0.839819790479292 0.0191511204448008 6.06625876196215 1 619.5 2386 False False 1.37425056623884 0.147939198576762 6.30344232307697 0.00048828125 1.23621345180143e-05 0.00271749449396634 0.999289543370148 0.998729153244051 0.999645290955256 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 1 7 2 8 1303 8634 0.00153256704980842 0.000185654897205815 0.00552508794778556 0.999074288359176 0.998176798225858 0.999600261389848 0.2 0.0252107263268333 0.556095462307641 0.125 0.0031597235312519 0.526509670875206 0.111111111111111 0.00280913674659921 0.482496514917337 0.946606731718013 0.0209875277058126 7.37876366012203 1 275.5 1774 False False 0 0 0 0 0 0 0 1.65656178050652 0.171165634473281 8.31340654465624 0.000766871165644171 1.94153084409271e-05 0.00426525037799214 0.999074288359176 0.998176798225858 0.999600261389848 5 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Val79fs whiB6_p.Val79fs 2 frameshift (see "Genomic_coordinates" sheet) 1 14 1 13 6 19 2043 15464 0.00292825768667642 0.00107535359935202 0.00636260998410225 0.998772847639346 0.998084309989574 0.999261017508711 0.24 0.0935644393317428 0.451288017816686 0.0714285714285714 0.00180678065912538 0.338684489931821 0.05 0.0012650894979498 0.248732762772027 0.582250837757445 0.0136971845708184 3.88083506160006 1 619.5 2386 False False 2.39029291289898 0.780341523842609 6.23400081343365 0.000489236790606653 1.2386326412255e-05 0.00272280654093039 0.998772847639346 0.998084309989574 0.999261017508711 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 1 4 3 5 1302 8637 0.00229885057471264 0.000474329389656033 0.00670338609202181 0.999421430224485 0.99865033199523 0.999812114132187 0.375 0.0852334141372535 0.755136783633448 0.2 0.00505076337946806 0.716417936118089 0.166666666666666 0.00421074451448947 0.641234578997674 1.65841013824884 0.0336494575391042 16.7684757573773 0.504608479174915 104 1774 False False 0 0 0 0 0 0 0 3.98018433179723 0.617234495883032 20.4771262171732 0.00076745970836531 1.94302087631205e-05 0.00426851804482144 0.999421430224485 0.99865033199523 0.999812114132187 29 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Val79Gly whiB6_p.Val79Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 6 2049 15477 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 8.24842676385937 1 619.5 2386 False False 0 0 6.41986758323506 0 0 0.00179871197794837 0.999612478201898 0.999156720468893 0.999857773477374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1305 8640 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 35.2688392655279 1 503.5 1774 False False 0 0 0 0 0 0 0 0 0 35.2688392655279 0 0 0.00282273611850443 0.999768572089794 0.999164255486522 0.999971971777513 15 3) Uncertain significance No change no 1 +Capreomycin whiB6 p.Val80fs whiB6_p.Val80fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 2049 15482 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 0 0 0.975 0 0 0.975 0 0 0.975 0 0 293.352185327417 1 619.5 2386 False False 0 0 293.352185327417 0 0 0.00179871197794837 0.99993541303365 0.999640197578315 0.999998364800924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1305 8641 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 0 0 0.975 0 0 0.975 0 0 0.975 0 0 257.232645023805 1 275.5 1774 False False 0 0 0 0 0 0 0 0 0 257.232645023805 0 0 0.00282273611850443 0.999884286044897 0.999355453609522 0.999997070380594 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA c.-101A>T fbiA_c.-101A>T 2 upstream_gene_variant 3640442 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1254 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 546 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA c.-104C>A fbiA_c.-104C>A 2 upstream_gene_variant 3640439 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA c.-105T>C fbiA_c.-105T>C 2 upstream_gene_variant 3640438 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA c.-10G>A fbiA_c.-10G>A 2 upstream_gene_variant 3640533 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA c.-115C>G fbiA_c.-115C>G 2 upstream_gene_variant 3640428 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1275 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA c.-115C>T fbiA_c.-115C>T 2 upstream_gene_variant 3640428 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1267 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA c.-128T>C fbiA_c.-128T>C 2 upstream_gene_variant 3640415 1 4 0 4 0 4 674 14039 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 31.5916386345298 1 619 1319 False False 0 0 31.5916386345298 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA c.-129G>A fbiA_c.-129G>A 2 upstream_gene_variant 3640414 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA c.-129G>T fbiA_c.-129G>T 2 upstream_gene_variant 3640414 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA c.129T>C fbiA_c.129T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 674 14037 0 0 0.00545816471080279 0.999572740867336 0.999070270474308 0.999843187804675 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 17.7219093583043 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 214 4731 0 0 0.0170900343744659 0.999366286438529 0.998149147855346 0.999869293957204 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 53.7295049630073 NA NA NA NA NA NA 11 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiA c.-136G>A fbiA_c.-136G>A 2 upstream_gene_variant 3640407 1 4 0 4 0 5 674 14038 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 31.5895189679011 1 619 1319 False False 0 0 22.7684048554448 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 10 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA c.-136G>T fbiA_c.-136G>T 2 upstream_gene_variant 3640407 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 9 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA c.-13A>C fbiA_c.-13A>C 2 upstream_gene_variant 3640530 1 1 0 1 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 802.34555512305 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 851.098742087123 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA c.150C>T fbiA_c.150C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiA c.15T>C fbiA_c.15T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 62 673 13981 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.995584988962472 0.994343680171115 0.996613411164927 0.0158730158730158 0.000401789229084887 0.085295709299263 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.335066864784546 0.00834094656568044 1.94377753590707 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 17 214 4717 0 0 0.0170900343744659 0.996408956485002 0.994256597661709 0.997906735895158 0 0 0.195064322969093 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 5.38399812190603 NA NA NA NA NA NA 915 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiA c.162C>T fbiA_c.162C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiA c.-16G>A fbiA_c.-16G>A 2 upstream_gene_variant 3640527 1 3 0 3 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 50.4845768710802 1 619 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 214 4731 0 0 0.0170900343744659 0.999366286438529 0.998149147855346 0.999869293957204 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 53.7295049630073 1 83 572 False False 0 0 0 0 0 0 0 0 0 53.7295049630073 0 0 0.0170900343744659 0.999366286438529 0.998149147855346 0.999869293957204 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA c.180G>T fbiA_c.180G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiA c.-18G>A fbiA_c.-18G>A 2 upstream_gene_variant 3640525 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA c.195C>T fbiA_c.195C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiA c.204C>G fbiA_c.204C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 118.033875066473 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiA c.-20G>A fbiA_c.-20G>A 2 upstream_gene_variant 3640523 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1265 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA c.213C>T fbiA_c.213C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 673 14042 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999928790144556 0.999603308654684 0.999998197124178 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 20.8647845468053 0.265412371331172 1613.44310281692 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiA c.264C>T fbiA_c.264C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiA c.-26G>A fbiA_c.-26G>A 2 upstream_gene_variant 3640517 1 0 0 0 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1274 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 553 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA c.270G>A fbiA_c.270G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiA c.-27G>A fbiA_c.-27G>A 2 upstream_gene_variant 3640516 1 0 0 0 0 4 674 14039 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1263 1319 False False 0 0 31.5916386345298 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 214 4730 0 0 0.0170900343744659 0.999155048584706 0.997838014616212 0.999769732715123 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 550 572 False False 0 0 0 0 0 0 0 0 0 33.6387430781262 0 0 0.0170900343744659 0.999155048584706 0.997838014616212 0.999769732715123 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA c.288C>T fbiA_c.288C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiA c.318C>T fbiA_c.318C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiA c.337C>T fbiA_c.337C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 65 670 13978 0.0059347181008902 0.00161930788766713 0.0151250012595154 0.99537135939614 0.994104169195298 0.996425950607552 0.0579710144927536 0.0160191585330932 0.141828907792285 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.28385763490241 0.338635318280945 3.46379315512326 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 10 213 4724 0.00467289719626168 0.000118300515887328 0.0257593138532706 0.997887621461766 0.996118702879007 0.998986582156994 0.0909090909090909 0.00229897221381426 0.412779916988382 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.21784037558685 0.0508690570791212 15.7111015491691 NA NA NA NA NA NA 106 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiA c.363C>G fbiA_c.363C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiA c.372C>T fbiA_c.372C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiA c.432T>G fbiA_c.432T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 10 674 14033 0 0 0.00545816471080279 0.99928790144556 0.998690816610614 0.99965846992849 0 0 0.30849710781876 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.30775405122037 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 78 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiA c.468C>T fbiA_c.468C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 674 14039 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.5916386345298 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 14 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiA c.471C>T fbiA_c.471C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 673 14041 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999857580289112 0.999485626730555 0.999982751846902 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 10.4316493313521 0.176556008630772 200.333455094347 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiA c.51C>A fbiA_c.51C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiA c.-51G>A fbiA_c.-51G>A 2 upstream_gene_variant 3640492 NA 0 0 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1250 1319 False False Inf 0.534232413570953 Inf 0 0 0.00546625270429624 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA c.522G>A fbiA_c.522G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiA c.531T>C fbiA_c.531T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiA c.546G>T fbiA_c.546G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiA c.579C>A fbiA_c.579C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiA c.615C>T fbiA_c.615C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 6 673 14037 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999572740867336 0.999070270474308 0.999843187804675 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.47622585438335 0.0754632221460442 28.7341429523688 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiA c.-63_-59delCGTGT fbiA_c.-63_-59delCGTGT 2 upstream_gene_variant 3640479 NA 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1266 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA c.-65G>A fbiA_c.-65G>A 2 upstream_gene_variant 3640478 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA c.666C>T fbiA_c.666C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiA c.-66C>T fbiA_c.-66C>T 2 upstream_gene_variant 3640477 1 1 0 1 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 802.34555512305 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA c.672G>A fbiA_c.672G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiA c.693G>T fbiA_c.693G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 50.4845768710802 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiA c.696G>A fbiA_c.696G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 674 14038 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 22.7684048554448 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 214 4730 0 0 0.0170900343744659 0.999155048584706 0.997838014616212 0.999769732715123 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 33.6387430781262 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiA c.-69T>C fbiA_c.-69T>C 2 upstream_gene_variant 3640474 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA c.72C>T fbiA_c.72C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiA c.-72G>C fbiA_c.-72G>C 2 upstream_gene_variant 3640471 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 118.033875066473 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 2 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA c.744C>A fbiA_c.744C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiA c.744C>T fbiA_c.744C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 50.4845768710802 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiA c.75G>A fbiA_c.75G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiA c.75G>C fbiA_c.75G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiA c.-75G>C fbiA_c.-75G>C 2 upstream_gene_variant 3640468 1 5 0 5 0 5 674 14038 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 22.7684048554448 1 169 1319 False False 0 0 22.7684048554448 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 214 4729 0 0 0.0170900343744659 0.998943810730883 0.997536942130593 0.999656972101492 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 24.2508634033673 1 83 572 False False 0 0 0 0 0 0 0 0 0 24.2508634033673 0 0 0.0170900343744659 0.998943810730883 0.997536942130593 0.999656972101492 17 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA c.762C>T fbiA_c.762C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiA c.792G>T fbiA_c.792G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiA c.-7C>G fbiA_c.-7C>G 2 upstream_gene_variant 3640536 1 0 0 0 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1247 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA c.816G>A fbiA_c.816G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiA c.81G>A fbiA_c.81G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiA c.-81G>A fbiA_c.-81G>A 2 upstream_gene_variant 3640462 1 4 0 4 0 4 674 14039 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 31.5916386345298 1 619 1319 False False 0 0 31.5916386345298 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA c.837G>A fbiA_c.837G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiA c.843C>G fbiA_c.843C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiA c.852A>C fbiA_c.852A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiA c.852A>T fbiA_c.852A>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 674 14039 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.5916386345298 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiA c.867G>A fbiA_c.867G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 50.4845768710802 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiA c.-86G>C fbiA_c.-86G>C 2 upstream_gene_variant 3640457 1 4 0 4 0 4 674 14039 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 31.5916386345298 1 619 1319 False False 0 0 31.5916386345298 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 214 4730 0 0 0.0170900343744659 0.999155048584706 0.997838014616212 0.999769732715123 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 33.6387430781262 1 83 572 False False 0 0 0 0 0 0 0 0 0 33.6387430781262 0 0 0.0170900343744659 0.999155048584706 0.997838014616212 0.999769732715123 4 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA c.870G>A fbiA_c.870G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiA c.888T>C fbiA_c.888T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiA c.900G>A fbiA_c.900G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiA c.903G>A fbiA_c.903G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiA c.912G>A fbiA_c.912G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 9 674 14034 0 0 0.00545816471080279 0.999359111301004 0.998783743811125 0.999706904333134 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 10.5701597897411 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 15 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiA c.925C>T fbiA_c.925C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiA c.936C>T fbiA_c.936C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiA c.978T>C fbiA_c.978T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiA c.-97A>T fbiA_c.-97A>T 2 upstream_gene_variant 3640446 1 9 0 9 0 12 674 14031 0 0 0.00545816471080279 0.999145481734672 0.998507804828235 0.999558382465294 0 0 0.264648469397051 0 0 0.336267116879942 0 0 0.264648469397051 0 0 10.5679007059331 1 619 1319 False False 0 0 7.50790373059148 0 0 0.00545816471080279 0.999145481734672 0.998507804828235 0.999558382465294 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 851.098742087123 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 35 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA c.-98delA fbiA_c.-98delA 2 upstream_gene_variant 3640444 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA LoF fbiA_LoF 2 LoF (see "Genomic_coordinates" sheet) NA 0 0 0 2 1 672 14042 0.0029673590504451 0.000359563182310977 0.0106776554748576 0.999928790144556 0.999603308654684 0.999998197124178 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 1319 1319 False False 41.7916666666666 2.17098038345829 2418.88338333889 0 0 0.00547436470313033 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 1 212 4733 0.00934579439252336 0.00113382977970066 0.0333506066446319 0.999788762146176 0.998823626139438 0.999994651934878 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 572 572 False False 0 0 0 0 0 0 0 44.6509433962264 2.308987944757 2580.78641290913 0 0 0.0172498625165958 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Ala166Glu fbiA_p.Ala166Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Ala178Thr fbiA_p.Ala178Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1270 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Ala190Thr fbiA_p.Ala190Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1248 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Ala199Thr fbiA_p.Ala199Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1268 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Ala206Thr fbiA_p.Ala206Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 673 14042 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999928790144556 0.999603308654684 0.999998197124178 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 803.579283928634 1 619 1319 False False 20.8647845468053 0.265412371331172 1613.44310281692 0 0 0.00546625270429624 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Ala222Thr fbiA_p.Ala222Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Ala225Val fbiA_p.Ala225Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Ala296Ser fbiA_p.Ala296Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Ala29Thr fbiA_p.Ala29Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.534232413570953 Inf 0.0457973771828497 55 1319 False False Inf 0.534232413570953 Inf 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Ala30Thr fbiA_p.Ala30Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 3 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Ala30Val fbiA_p.Ala30Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1255 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Ala327Thr fbiA_p.Ala327Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1259 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Ala33Asp fbiA_p.Ala33Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Ala43Thr fbiA_p.Ala43Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 674 14039 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 31.5916386345298 1 619 1319 False False 0 0 31.5916386345298 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Arg175His fbiA_p.Arg175His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Arg177His fbiA_p.Arg177His 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 674 14039 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 31.5916386345298 1 619 1319 False False 0 0 31.5916386345298 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Arg304Gln fbiA_p.Arg304Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.534232413570953 Inf 0.0457973771828497 55 1319 False False Inf 0.534232413570953 Inf 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 213 4734 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.56721266938512 Inf 0.0432497978981406 34 572 False False 0 0 0 0 0 0 0 Inf 0.56721266938512 Inf 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 10 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Arg321Ser fbiA_p.Arg321Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 673 14042 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999928790144556 0.999603308654684 0.999998197124178 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 20.8647845468053 0.265412371331172 1613.44310281692 0.0895003241642821 90 1319 False False 20.8647845468053 0.265412371331172 1613.44310281692 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Asn314Lys fbiA_p.Asn314Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Asp100Asn fbiA_p.Asp100Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Asp292Gly fbiA_p.Asp292Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Asp299Ala fbiA_p.Asp299Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Asp312Gly fbiA_p.Asp312Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1258 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 548 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 24 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Asp83Asn fbiA_p.Asp83Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1264 1319 False False Inf 0.534232413570953 Inf 0 0 0.00546625270429624 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 213 4734 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 551 572 False False 0 0 0 0 0 0 0 Inf 0.56721266938512 Inf 0 0 0.0171695765109405 1 0.999221072542716 1 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Cys280Gly fbiA_p.Cys280Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Cys280Ser fbiA_p.Cys280Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Cys287Tyr fbiA_p.Cys287Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Gln120Arg fbiA_p.Gln120Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 7 674 14036 0 0 0.00545816471080279 0.999501531011892 0.998973234784508 0.999799566877855 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 14.476435679416 1 169 1319 False False 0 0 14.476435679416 0 0 0.00545816471080279 0.999501531011892 0.998973234784508 0.999799566877855 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Gln21Leu fbiA_p.Gln21Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Gln27Pro fbiA_p.Gln27Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 1 2 673 14041 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999857580289112 0.999485626730555 0.999982751846902 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 10.4316493313521 0.176556008630772 200.333455094347 0.131204488725157 100 1319 False False 10.4316493313521 0.176556008630772 200.333455094347 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Gln40Arg fbiA_p.Gln40Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Glu130Asp fbiA_p.Glu130Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1251 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Glu130Lys fbiA_p.Glu130Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1262 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Gly189Ser fbiA_p.Gly189Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Gly264Arg fbiA_p.Gly264Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 19 0 19 0 22 674 14021 0 0 0.00545816471080279 0.998433383180232 0.997629078392245 0.999017957301543 0 0 0.154372512815574 0 0 0.176466911806965 0 0 0.154372512815574 0 0 4.46899637990592 1 619 1319 False False 0 0 3.80746510250222 0 0 0.00545816471080279 0.998433383180232 0.997629078392245 0.999017957301543 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 53 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Gly26Ser fbiA_p.Gly26Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Gly277Ser fbiA_p.Gly277Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 50.4845768710802 1 619 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 118.033875066473 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 2 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Gly293Ala fbiA_p.Gly293Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Gly300Arg fbiA_p.Gly300Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Gly48Ser fbiA_p.Gly48Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Gly70Ser fbiA_p.Gly70Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Gly71Ser fbiA_p.Gly71Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1261 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 549 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 3 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Gly78Ser fbiA_p.Gly78Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Gly8Ala fbiA_p.Gly8Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.His183Gln fbiA_p.His183Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 118.033875066473 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.His295Arg fbiA_p.His295Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 674 14038 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 22.7684048554448 1 169 1319 False False 0 0 22.7684048554448 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Ile208Val fbiA_p.Ile208Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 34 0 34 0 40 674 14003 0 0 0.00545816471080279 0.99715160578224 0.996123294330248 0.997964309449701 0 0 0.0880973028788023 0 0 0.102817924259012 0 0 0.0880973028788023 0 0 2.38740813261826 0.405520683042845 128 1319 False False 0 0 2.01269062319881 0 0 0.00545816471080279 0.99715160578224 0.996123294330248 0.997964309449701 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 214 4730 0 0 0.0170900343744659 0.999155048584706 0.997838014616212 0.999769732715123 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 33.6387430781262 1 83 572 False False 0 0 0 0 0 0 0 0 0 33.6387430781262 0 0 0.0170900343744659 0.999155048584706 0.997838014616212 0.999769732715123 140 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Ile229Met fbiA_p.Ile229Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1252 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Ile229Val fbiA_p.Ile229Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 118.033875066473 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Ile53Thr fbiA_p.Ile53Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.534232413570953 Inf 0.0457973771828497 55 1319 False False Inf 0.534232413570953 Inf 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Ile53Val fbiA_p.Ile53Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Leu104Phe fbiA_p.Leu104Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1269 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Leu132Val fbiA_p.Leu132Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1253 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Leu211Val fbiA_p.Leu211Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Leu22Val fbiA_p.Leu22Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 674 14037 0 0 0.00545816471080279 0.999572740867336 0.999070270474308 0.999843187804675 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 17.7219093583043 1 169 1319 False False 0 0 17.7219093583043 0 0 0.00545816471080279 0.999572740867336 0.999070270474308 0.999843187804675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 214 4728 0 0 0.0170900343744659 0.998732572877059 0.997243401195562 0.999534739052189 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 18.8747365567989 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 18.8747365567989 0 0 0.0170900343744659 0.998732572877059 0.997243401195562 0.999534739052189 5 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Phe102Leu fbiA_p.Phe102Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Pro227Thr fbiA_p.Pro227Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Pro239Ser fbiA_p.Pro239Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Pro245Ser fbiA_p.Pro245Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Ser184Thr fbiA_p.Ser184Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 4 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Ser194Gly fbiA_p.Ser194Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1271 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Ser32Phe fbiA_p.Ser32Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Ser35Ala fbiA_p.Ser35Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 674 14037 0 0 0.00545816471080279 0.999572740867336 0.999070270474308 0.999843187804675 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 17.7219093583043 1 169 1319 False False 0 0 17.7219093583043 0 0 0.00545816471080279 0.999572740867336 0.999070270474308 0.999843187804675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Ser35Leu fbiA_p.Ser35Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Ser42Cys fbiA_p.Ser42Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Ser42Gly fbiA_p.Ser42Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Thr111Ile fbiA_p.Thr111Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Thr302Ala fbiA_p.Thr302Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1249 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Thr302Met fbiA_p.Thr302Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 102 670 13941 0.0059347181008902 0.00161930788766713 0.0151250012595154 0.992736594744712 0.991189580607504 0.994073792384291 0.0377358490566037 0.0103758563611655 0.0938056387691604 NA NA NA 0 0 0.035519326657884 NA NA NA NA 1257 1319 False True 0.815978928884986 0.21750982584494 2.16395568489002 0 0 0.00549066114558213 0.992736594744712 0.991189580607504 0.994073792384291 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 39 214 4695 0 0 0.0170900343744659 0.991761723700887 0.988755048008162 0.994135409254702 0 0 0.0902511009603342 NA NA NA 0 0 0.0902511009603342 NA NA NA NA 547 572 False True 1 1 1 0 0 0 0 0 0 2.19533967614766 0 0 0.0170900343744659 0.991761723700887 0.988755048008162 0.994135409254702 501 5) Not assoc w R New NotAwR yes 5 +Clofazimine fbiA p.Thr4Asn fbiA_p.Thr4Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1260 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Trp101Cys fbiA_p.Trp101Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Val114Leu fbiA_p.Val114Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Val160Ile fbiA_p.Val160Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Val180Met fbiA_p.Val180Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Val188Ala fbiA_p.Val188Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1273 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Val188Ile fbiA_p.Val188Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 11 674 14032 0 0 0.00545816471080279 0.999216691590116 0.998598878125098 0.999608912470572 0 0 0.284914152918154 NA NA NA 0 0 0.284914152918154 NA NA NA NA 1256 1319 False False 0 0 8.31593780715244 0 0 0.00545816471080279 0.999216691590116 0.998598878125098 0.999608912470572 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Val188Phe fbiA_p.Val188Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 50.4845768710802 1 619 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 16 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Val217Gly fbiA_p.Val217Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Val217Met fbiA_p.Val217Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1276 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 554 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Val262Ile fbiA_p.Val262Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Val265Met fbiA_p.Val265Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Val306Met fbiA_p.Val306Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 50.4845768710802 1 619 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Val329fs fbiA_p.Val329fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 1 672 14042 0.0029673590504451 0.000359563182310977 0.0106776554748576 0.999928790144556 0.999603308654684 0.999998197124178 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 1277 1319 False False 41.7916666666666 2.17098038345829 2418.88338333889 0 0 0.00547436470313033 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 1 212 4733 0.00934579439252336 0.00113382977970066 0.0333506066446319 0.999788762146176 0.998823626139438 0.999994651934878 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 555 572 False False 0 0 0 0 0 0 0 44.6509433962264 2.308987944757 2580.78641290913 0 0 0.0172498625165958 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiA p.Val47Ile fbiA_p.Val47Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1272 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 552 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 4 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB c.1002G>C fbiB_c.1002G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.1035C>T fbiB_c.1035C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.1041C>A fbiB_c.1041C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.108G>A fbiB_c.108G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.1095C>G fbiB_c.1095C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 18 674 14025 0 0 0.00545816471080279 0.998718222602008 0.997974992709242 0.999240166128232 0 0 0.185301968137852 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.74493670386334 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 18 214 4716 0 0 0.0170900343744659 0.996197718631178 0.993997388291213 0.997745017823554 0 0 0.185301968137852 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 5.0524201521135 NA NA NA NA NA NA 29 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.1122G>A fbiB_c.1122G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.1164G>C fbiB_c.1164G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.1200G>A fbiB_c.1200G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.1206C>T fbiB_c.1206C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.1266C>G fbiB_c.1266C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.1272C>T fbiB_c.1272C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.1293G>A fbiB_c.1293G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.1330T>C fbiB_c.1330T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.1335G>A fbiB_c.1335G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 50.4845768710802 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 214 4731 0 0 0.0170900343744659 0.999366286438529 0.998149147855346 0.999869293957204 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 53.7295049630073 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.135C>A fbiB_c.135C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.150C>T fbiB_c.150C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.156G>A fbiB_c.156G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.159G>T fbiB_c.159G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.171G>A fbiB_c.171G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.174C>T fbiB_c.174C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.198C>T fbiB_c.198C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.207A>G fbiB_c.207A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.21C>T fbiB_c.21C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.243G>A fbiB_c.243G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 674 14039 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.5916386345298 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.273C>G fbiB_c.273C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 11 674 14032 0 0 0.00545816471080279 0.999216691590116 0.998598878125098 0.999608912470572 0 0 0.284914152918154 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.31593780715244 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 13 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.276G>C fbiB_c.276G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 17 674 14026 0 0 0.00545816471080279 0.998789432457452 0.998062469319839 0.999294646641111 0 0 0.195064322969093 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.05582688025084 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 6 214 4728 0 0 0.0170900343744659 0.998732572877059 0.997243401195562 0.999534739052189 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 18.8747365567989 NA NA NA NA NA NA 145 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.294A>C fbiB_c.294A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.324G>A fbiB_c.324G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 5 673 14038 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.99964395072278 0.999169297020829 0.999884381985141 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA NA NA NA NA NA NA NA NA NA False False 4.17176820208023 0.0880732176054642 37.3482568099296 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 118.033875066473 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.361C>T fbiB_c.361C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 20 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.399C>A fbiB_c.399C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.399C>T fbiB_c.399C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.408G>T fbiB_c.408G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.471C>G fbiB_c.471C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 16 674 14027 0 0 0.00545816471080279 0.998860642312896 0.998150412174592 0.999348622824847 0 0 0.205907214207822 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.41012600327403 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 13 214 4721 0 0 0.0170900343744659 0.997253907900295 0.995308676874106 0.998537036545967 0 0 0.24705263800047 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 7.29113432294717 NA NA NA NA NA NA 21 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.517C>T fbiB_c.517C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.531C>T fbiB_c.531C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.537C>T fbiB_c.537C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.546A>G fbiB_c.546A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.552C>T fbiB_c.552C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.564G>A fbiB_c.564G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 24 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.573G>A fbiB_c.573G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 5 672 14038 0.0029673590504451 0.000359563182310977 0.0106776554748576 0.99964395072278 0.999169297020829 0.999884381985141 0.285714285714285 0.0366925661760855 0.709579136262657 NA NA NA NA NA NA NA NA NA NA NA NA False False 8.35595238095238 0.794034598155219 51.1554476298512 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.57G>A fbiB_c.57G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.60G>A fbiB_c.60G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.636G>A fbiB_c.636G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.636G>C fbiB_c.636G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.639G>A fbiB_c.639G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 10 674 14033 0 0 0.00545816471080279 0.99928790144556 0.998690816610614 0.99965846992849 0 0 0.30849710781876 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.30775405122037 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 214 4730 0 0 0.0170900343744659 0.999155048584706 0.997838014616212 0.999769732715123 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 33.6387430781262 NA NA NA NA NA NA 51 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.654T>C fbiB_c.654T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 50.4845768710802 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.663C>A fbiB_c.663C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.678C>T fbiB_c.678C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.688C>A fbiB_c.688C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.699G>A fbiB_c.699G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.708C>A fbiB_c.708C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.738C>T fbiB_c.738C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.759C>T fbiB_c.759C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.762G>A fbiB_c.762G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.783G>A fbiB_c.783G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.810G>A fbiB_c.810G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 118.033875066473 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.84T>C fbiB_c.84T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.888A>G fbiB_c.888A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.90C>T fbiB_c.90C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 2 671 14041 0.00445103857566765 0.00091885344774779 0.0129522747681396 0.999857580289112 0.999485626730555 0.999982751846902 0.6 0.146632799634673 0.947255049473683 NA NA NA NA NA NA NA NA NA NA NA NA False False 31.3882265275707 3.58598009676545 374.022606672895 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 1 211 4733 0.014018691588785 0.00290037436233909 0.0404197483900649 0.999788762146176 0.998823626139438 0.999994651934878 0.75 0.194120449683243 0.99369053679029 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 67.2938388625592 5.35918686807633 3442.86749401627 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.936G>T fbiB_c.936G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 50.4845768710802 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 214 4731 0 0 0.0170900343744659 0.999366286438529 0.998149147855346 0.999869293957204 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 53.7295049630073 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.957T>C fbiB_c.957T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.969T>C fbiB_c.969T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB c.996A>G fbiB_c.996A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiB LoF fbiB_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Ala127Thr fbiB_p.Ala127Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1227 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Ala164Thr fbiB_p.Ala164Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1229 1319 False False Inf 0.534232413570953 Inf 0 0 0.00546625270429624 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 213 4734 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 539 572 False False 0 0 0 0 0 0 0 Inf 0.56721266938512 Inf 0 0 0.0171695765109405 1 0.999221072542716 1 5 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Ala200Glu fbiB_p.Ala200Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1217 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Ala286Gly fbiB_p.Ala286Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Ala304Asp fbiB_p.Ala304Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Ala31Thr fbiB_p.Ala31Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 55 0 55 0 60 674 13983 0 0 0.00545816471080279 0.99572740867336 0.994503704395014 0.996738026580749 0 0 0.0596294922861668 0 0 0.0648707608254246 0 0 0.0596294922861668 0 0 1.44323884628721 0.181803674720911 111 1319 False False 0 0 1.31927133036188 0 0 0.00545816471080279 0.99572740867336 0.994503704395014 0.996738026580749 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 81 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Ala32Val fbiB_p.Ala32Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Ala376Thr fbiB_p.Ala376Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Ala441Val fbiB_p.Ala441Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 50.4845768710802 1 619 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 214 4731 0 0 0.0170900343744659 0.999366286438529 0.998149147855346 0.999869293957204 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 53.7295049630073 1 83 572 False False 0 0 0 0 0 0 0 0 0 53.7295049630073 0 0 0.0170900343744659 0.999366286438529 0.998149147855346 0.999869293957204 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Ala82Thr fbiB_p.Ala82Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 50.4845768710802 1 619 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Arg174His fbiB_p.Arg174His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1215 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Arg230Gln fbiB_p.Arg230Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1218 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 534 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 24 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Arg253His fbiB_p.Arg253His 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 50.4845768710802 1 619 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Arg265Gln fbiB_p.Arg265Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 50.4845768710802 1 619 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Arg293Gln fbiB_p.Arg293Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1223 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Arg293Gly fbiB_p.Arg293Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Arg312Gln fbiB_p.Arg312Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1219 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 535 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Arg334Gln fbiB_p.Arg334Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1221 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Arg365Gly fbiB_p.Arg365Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 674 14038 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 22.7684048554448 1 169 1319 False False 0 0 22.7684048554448 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 214 4729 0 0 0.0170900343744659 0.998943810730883 0.997536942130593 0.999656972101492 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 24.2508634033673 1 83 572 False False 0 0 0 0 0 0 0 0 0 24.2508634033673 0 0 0.0170900343744659 0.998943810730883 0.997536942130593 0.999656972101492 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Arg409Ser fbiB_p.Arg409Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 674 14039 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 50.4809680276667 1 619 1319 False False 0 0 31.5916386345298 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 214 4731 0 0 0.0170900343744659 0.999366286438529 0.998149147855346 0.999869293957204 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 118.009213097229 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 53.7295049630073 0 0 0.0170900343744659 0.999366286438529 0.998149147855346 0.999869293957204 12 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Asp109Glu fbiB_p.Asp109Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Asp224Asn fbiB_p.Asp224Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Asp225Asn fbiB_p.Asp225Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Asp311Ala fbiB_p.Asp311Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Asp315Ala fbiB_p.Asp315Ala 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 673 14042 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999928790144556 0.999603308654684 0.999998197124178 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1214 1319 False False 20.8647845468053 0.265412371331172 1613.44310281692 0 0 0.00546625270429624 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 27 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Asp315His fbiB_p.Asp315His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.534232413570953 Inf 0.0457973771828497 55 1319 False False Inf 0.534232413570953 Inf 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Asp343Ala fbiB_p.Asp343Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Asp417Ala fbiB_p.Asp417Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 802.34555512305 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 4 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Asp430His fbiB_p.Asp430His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Asp437Ala fbiB_p.Asp437Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Asp437Gly fbiB_p.Asp437Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1216 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Asp66Glu fbiB_p.Asp66Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 674 14038 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 22.7684048554448 1 169 1319 False False 0 0 22.7684048554448 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Asp90Asn fbiB_p.Asp90Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 11 0 11 0 12 674 14031 0 0 0.00545816471080279 0.999145481734672 0.998507804828235 0.999558382465294 0 0 0.264648469397051 0 0 0.284914152918154 0 0 0.264648469397051 0 0 8.31534514669318 1 619 1319 False False 0 0 7.50790373059148 0 0 0.00545816471080279 0.999145481734672 0.998507804828235 0.999558382465294 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 0 11 214 4723 0 0 0.0170900343744659 0.997676383607942 0.995846220600476 0.998839506172504 0 0 0.284914152918154 0 0 0.30849710781876 0 0 0.284914152918154 0 0 9.91354149151956 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 8.85892377666813 0 0 0.0170900343744659 0.997676383607942 0.995846220600476 0.998839506172504 20 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Asp90Glu fbiB_p.Asp90Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Asp90Gly fbiB_p.Asp90Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Gln339Arg fbiB_p.Gln339Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Gln69Arg fbiB_p.Gln69Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 802.34555512305 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Glu138Lys fbiB_p.Glu138Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Glu191Asp fbiB_p.Glu191Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Glu191Gln fbiB_p.Glu191Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Glu332Lys fbiB_p.Glu332Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 674 14038 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 22.7684048554448 1 169 1319 False False 0 0 22.7684048554448 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 214 4729 0 0 0.0170900343744659 0.998943810730883 0.997536942130593 0.999656972101492 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 24.2508634033673 1 83 572 False False 0 0 0 0 0 0 0 0 0 24.2508634033673 0 0 0.0170900343744659 0.998943810730883 0.997536942130593 0.999656972101492 2 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Glu65Lys fbiB_p.Glu65Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Gly178Asp fbiB_p.Gly178Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Gly325Ser fbiB_p.Gly325Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 674 14039 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 31.5916386345298 1 619 1319 False False 0 0 31.5916386345298 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Gly3Asp fbiB_p.Gly3Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Gly3Ser fbiB_p.Gly3Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Gly434Glu fbiB_p.Gly434Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1224 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 538 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.His370Arg fbiB_p.His370Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1231 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Ile18Asn fbiB_p.Ile18Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 118.033875066473 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 2 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Ile18Thr fbiB_p.Ile18Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 118.033875066473 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Ile18Val fbiB_p.Ile18Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.534232413570953 Inf 0.0457973771828497 55 1319 False False Inf 0.534232413570953 Inf 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 213 4734 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.56721266938512 Inf 0.0432497978981406 34 572 False False 0 0 0 0 0 0 0 Inf 0.56721266938512 Inf 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Ile446Thr fbiB_p.Ile446Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1225 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Leu284Val fbiB_p.Leu284Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Leu444Phe fbiB_p.Leu444Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 802.34555512305 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 537 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Leu447Arg fbiB_p.Leu447Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 32 3 29 4 29 670 14014 0.0059347181008902 0.00161930788766713 0.0151250012595154 0.997934914192124 0.997035528243125 0.998616556898061 0.121212121212121 0.0340328814229786 0.28201622853722 0.09375 0.0197671801732848 0.250226950683794 0.09375 0.0197671801732848 0.250226950683794 2.16376737004632 0.420712510010292 7.00840613361116 0.178666362534541 110 1319 False False 2.88502316006176 0.734725178021518 8.24887713405256 0.00445765230312035 0.000920220162195385 0.0129714378400378 0.997934914192124 0.997035528243125 0.998616556898061 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 3 213 4731 0.00467289719626168 0.000118300515887328 0.0257593138532706 0.999366286438529 0.998149147855346 0.999869293957204 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 53.9842412500409 1 279.5 572 False False 0 0 0 0 0 0 0 7.4037558685446 0.140378463696898 92.7502763441399 0 0 0.0171695765109405 0.999366286438529 0.998149147855346 0.999869293957204 107 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Lys206Asn fbiB_p.Lys206Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Lys448Arg fbiB_p.Lys448Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 132 9 123 32 169 642 13874 0.0474777448071216 0.0326980522798666 0.0663661385188962 0.987965534429965 0.986021816366592 0.989702922342937 0.159203980099502 0.111515909262998 0.21725118090725 0.0681818181818181 0.0316489385438891 0.125484589194484 0.0505617977528089 0.023377654083422 0.0938097093676166 1.58126282197401 0.703005542092755 3.12004758551589 0.196676247197546 112 1319 False False 4.09194639532526 2.68938549217052 6.0539156440784 0.0138248847926267 0.00634058491540552 0.02608113152041 0.987965534429965 0.986021816366592 0.989702922342937 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 76 7 69 28 92 186 4642 0.130841121495327 0.0887344494094846 0.183522821947834 0.980566117448246 0.976218674952918 0.984305517414279 0.233333333333333 0.160991688096462 0.31927748928006 0.0921052631578947 0.0378380519179639 0.180607891410606 0.0707070707070707 0.0288990847755414 0.14026926582722 2.53186847436496 0.967754156480232 5.60336732387075 0.0289709480865558 19 572 False False 0 0 0 0 0 0 0 7.5956054230949 4.66442743698497 12.0348814665274 0.0362694300518134 0.0147043658068088 0.0732983299888598 0.980566117448246 0.976218674952918 0.984305517414279 301 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Phe403Leu fbiB_p.Phe403Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Pro122Ala fbiB_p.Pro122Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Pro25Arg fbiB_p.Pro25Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Pro294Ser fbiB_p.Pro294Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Pro303Thr fbiB_p.Pro303Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Pro361Leu fbiB_p.Pro361Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Pro440Ser fbiB_p.Pro440Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 802.34555512305 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 851.098742087123 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 8 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Ser30Arg fbiB_p.Ser30Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1220 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Ser323Asn fbiB_p.Ser323Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1213 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 533 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 2 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Ser323Gly fbiB_p.Ser323Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Ser433Pro fbiB_p.Ser433Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1232 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Thr212Ala fbiB_p.Thr212Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Thr268Ala fbiB_p.Thr268Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Thr268Ile fbiB_p.Thr268Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 802.34555512305 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 2 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Thr292Ala fbiB_p.Thr292Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 673 14042 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999928790144556 0.999603308654684 0.999998197124178 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1230 1319 False False 20.8647845468053 0.265412371331172 1613.44310281692 0 0 0.00546625270429624 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Thr371Ile fbiB_p.Thr371Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1228 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Thr374Lys fbiB_p.Thr374Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 1 2 673 14041 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999857580289112 0.999485626730555 0.999982751846902 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 10.4316493313521 0.176556008630772 200.333455094347 0.131204488725157 100 1319 False False 10.4316493313521 0.176556008630772 200.333455094347 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Trp418Ser fbiB_p.Trp418Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Tyr183Cys fbiB_p.Tyr183Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Val17Ala fbiB_p.Val17Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 9 674 14034 0 0 0.00545816471080279 0.999359111301004 0.998783743811125 0.999706904333134 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1222 1319 False False 0 0 10.5701597897411 0 0 0.00545816471080279 0.999359111301004 0.998783743811125 0.999706904333134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 9 214 4725 0 0 0.0170900343744659 0.998098859315589 0.996394124094466 0.999130320470377 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 536 572 False False 0 0 0 0 0 0 0 0 0 11.2606469033018 0 0 0.0170900343744659 0.998098859315589 0.996394124094466 0.999130320470377 53 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Val17fs fbiB_p.Val17fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Val17Ile fbiB_p.Val17Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Val192Ile fbiB_p.Val192Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1226 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Val194Ile fbiB_p.Val194Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 2 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Val214Leu fbiB_p.Val214Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Val217_Gly378del fbiB_p.Val217_Gly378del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Val348Ile fbiB_p.Val348Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 111.092568149139 1 169 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 12 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiB p.Val416Ile fbiB_p.Val416Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 802.34555512305 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 10 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC c.-100C>G fbiC_c.-100C>G 2 upstream_gene_variant 1302831 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC c.-100C>T fbiC_c.-100C>T 2 upstream_gene_variant 1302831 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1288 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 558 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC c.1014G>A fbiC_c.1014G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 118.033875066473 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.1023C>T fbiC_c.1023C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 118.033875066473 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.-105G>A fbiC_c.-105G>A 2 upstream_gene_variant 1302826 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC c.1065C>T fbiC_c.1065C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.-10G>A fbiC_c.-10G>A 2 upstream_gene_variant 1302921 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC c.-110G>A fbiC_c.-110G>A 2 upstream_gene_variant 1302821 1 5 0 5 0 6 674 14037 0 0 0.00545816471080279 0.999572740867336 0.999070270474308 0.999843187804675 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 22.7667854541547 1 169 1319 False False 0 0 17.7219093583043 0 0 0.00545816471080279 0.999572740867336 0.999070270474308 0.999843187804675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 118.033875066473 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 81 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC c.-111C>T fbiC_c.-111C>T 2 upstream_gene_variant 1302820 1 1 0 1 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 802.34555512305 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC c.-113G>A fbiC_c.-113G>A 2 upstream_gene_variant 1302818 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1307 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC c.-113G>C fbiC_c.-113G>C 2 upstream_gene_variant 1302818 1 0 0 0 3 28 671 14015 0.00445103857566765 0.00091885344774779 0.0129522747681396 0.998006124047568 0.99711957355846 0.998674687640767 0.0967741935483871 0.0204198626877921 0.257539064627735 NA NA NA 0 0 0.123436118500263 NA NA NA NA 1313 1319 False False 2.23786459442197 0.434277714220506 7.27299293500658 0 0 0.00548250081433617 0.998006124047568 0.99711957355846 0.998674687640767 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 31 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC c.1143C>T fbiC_c.1143C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 674 14037 0 0 0.00545816471080279 0.999572740867336 0.999070270474308 0.999843187804675 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 17.7219093583043 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 118.033875066473 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.-114C>T fbiC_c.-114C>T 2 upstream_gene_variant 1302817 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC c.1174C>T fbiC_c.1174C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.117G>A fbiC_c.117G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 50.4845768710802 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.1197A>C fbiC_c.1197A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.-11G>A fbiC_c.-11G>A 2 upstream_gene_variant 1302920 1 68 0 68 0 69 674 13974 0 0 0.00545816471080279 0.995086519974364 0.99378573657315 0.996175067757948 0 0 0.0520580578630797 0 0 0.0528030427936397 0 0 0.0520580578630797 0 0 1.15907664339677 0.0764376092552119 85 1319 False False 0 0 1.1417760314733 0 0 0.00545816471080279 0.995086519974364 0.99378573657315 0.996175067757948 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 214 4731 0 0 0.0170900343744659 0.999366286438529 0.998149147855346 0.999869293957204 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 53.7295049630073 1 83 572 False False 0 0 0 0 0 0 0 0 0 53.7295049630073 0 0 0.0170900343744659 0.999366286438529 0.998149147855346 0.999869293957204 52 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC c.-11G>T fbiC_c.-11G>T 2 upstream_gene_variant 1302920 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC c.1242G>C fbiC_c.1242G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.1248G>T fbiC_c.1248G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.-125C>T fbiC_c.-125C>T 2 upstream_gene_variant 1302806 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC c.1272G>A fbiC_c.1272G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.534232413570953 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.1314C>T fbiC_c.1314C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.1323G>A fbiC_c.1323G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.1323G>T fbiC_c.1323G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 673 14041 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999857580289112 0.999485626730555 0.999982751846902 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 10.4316493313521 0.176556008630772 200.333455094347 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 213 4734 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.56721266938512 Inf NA NA NA NA NA NA 68 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.1335C>T fbiC_c.1335C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 16 674 14027 0 0 0.00545816471080279 0.998860642312896 0.998150412174592 0.999348622824847 0 0 0.205907214207822 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.41012600327403 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 13 214 4721 0 0 0.0170900343744659 0.997253907900295 0.995308676874106 0.998537036545967 0 0 0.24705263800047 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 7.29113432294717 NA NA NA NA NA NA 21 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.1344T>C fbiC_c.1344T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.1380C>T fbiC_c.1380C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.534232413570953 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 213 4734 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.56721266938512 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.1383A>C fbiC_c.1383A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.1392C>T fbiC_c.1392C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.-14_-13insA fbiC_c.-14_-13insA 2 upstream_gene_variant 1302917 1 14 0 14 0 16 674 14027 0 0 0.00545816471080279 0.998860642312896 0.998150412174592 0.999348622824847 0 0 0.205907214207822 0 0 0.231635761650116 0 0 0.205907214207822 0 0 6.29007724370068 1 619 1319 False False 0 0 5.41012600327403 0 0 0.00545816471080279 0.998860642312896 0.998150412174592 0.999348622824847 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 214 4730 0 0 0.0170900343744659 0.999155048584706 0.997838014616212 0.999769732715123 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 33.6387430781262 1 83 572 False False 0 0 0 0 0 0 0 0 0 33.6387430781262 0 0 0.0170900343744659 0.999155048584706 0.997838014616212 0.999769732715123 53 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC c.1413T>G fbiC_c.1413T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 13 674 14030 0 0 0.00545816471080279 0.999074271879228 0.998417496974718 0.999506999611345 0 0 0.24705263800047 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 6.84763051410409 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.141G>A fbiC_c.141G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.534232413570953 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.1425G>A fbiC_c.1425G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 50.4845768710802 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 214 4731 0 0 0.0170900343744659 0.999366286438529 0.998149147855346 0.999869293957204 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 53.7295049630073 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.1447C>T fbiC_c.1447C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.1467A>G fbiC_c.1467A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.1470C>T fbiC_c.1470C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.1518C>T fbiC_c.1518C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.1521C>T fbiC_c.1521C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.1533C>T fbiC_c.1533C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.1545G>A fbiC_c.1545G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.1545G>C fbiC_c.1545G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.1569T>G fbiC_c.1569T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.156T>G fbiC_c.156T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.1572G>A fbiC_c.1572G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.1573C>T fbiC_c.1573C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.-15G>T fbiC_c.-15G>T 2 upstream_gene_variant 1302916 1 0 0 0 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1310 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC c.1635C>T fbiC_c.1635C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 674 14038 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 22.7684048554448 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 14 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.165G>A fbiC_c.165G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 197 671 13846 0.00445103857566765 0.00091885344774779 0.0129522747681396 0.985971658477533 0.983886986006772 0.987851217292856 0.015 0.00310410762155351 0.0432082819177126 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.314236649594892 0.0640935675948583 0.936013629634472 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 20 214 4714 0 0 0.0170900343744659 0.995775242923532 0.993482710675352 0.997417556793928 0 0 0.168433470983085 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.49785063365575 NA NA NA NA NA NA 677 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.1674C>T fbiC_c.1674C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.1680C>T fbiC_c.1680C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 15 673 14028 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.99893185216834 0.998238863574905 0.999402046418979 0.0625 0.00158111172276588 0.302320738434531 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.38959881129271 0.032960468682451 9.05913474030751 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 76 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.1692C>T fbiC_c.1692C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.1725C>T fbiC_c.1725C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.172C>T fbiC_c.172C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 118.033875066473 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.1734G>A fbiC_c.1734G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.1743C>T fbiC_c.1743C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 674 14038 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 22.7684048554448 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 5 214 4729 0 0 0.0170900343744659 0.998943810730883 0.997536942130593 0.999656972101492 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 24.2508634033673 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.1773C>T fbiC_c.1773C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 674 14037 0 0 0.00545816471080279 0.999572740867336 0.999070270474308 0.999843187804675 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 17.7219093583043 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 15 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.1794A>G fbiC_c.1794A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.1833C>T fbiC_c.1833C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.1842C>T fbiC_c.1842C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.1845C>A fbiC_c.1845C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.186C>T fbiC_c.186C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 12 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.-18C>T fbiC_c.-18C>T 2 upstream_gene_variant 1302913 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC c.18T>G fbiC_c.18T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 11 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.1902C>G fbiC_c.1902C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.1902C>T fbiC_c.1902C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.1923C>G fbiC_c.1923C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.195G>A fbiC_c.195G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.1989C>T fbiC_c.1989C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.1995G>A fbiC_c.1995G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.-1C>T fbiC_c.-1C>T 2 upstream_gene_variant 1302930 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 118.033875066473 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC c.2073C>T fbiC_c.2073C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.2088C>T fbiC_c.2088C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.2104C>T fbiC_c.2104C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.2130C>T fbiC_c.2130C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.2142C>T fbiC_c.2142C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.534232413570953 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.2176C>T fbiC_c.2176C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 50.4845768710802 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.2181C>T fbiC_c.2181C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.2196T>C fbiC_c.2196T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.2229G>A fbiC_c.2229G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.222C>T fbiC_c.222C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.2235G>A fbiC_c.2235G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 118.033875066473 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.2238C>T fbiC_c.2238C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.2250G>A fbiC_c.2250G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 13 674 14030 0 0 0.00545816471080279 0.999074271879228 0.998417496974718 0.999506999611345 0 0 0.24705263800047 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 6.84763051410409 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 11 214 4723 0 0 0.0170900343744659 0.997676383607942 0.995846220600476 0.998839506172504 0 0 0.284914152918154 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.85892377666813 NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.2259G>A fbiC_c.2259G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.2301C>T fbiC_c.2301C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.2304G>A fbiC_c.2304G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.2313T>G fbiC_c.2313T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.231G>A fbiC_c.231G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.237C>T fbiC_c.237C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.2409C>T fbiC_c.2409C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.2424C>T fbiC_c.2424C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.2427C>G fbiC_c.2427C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 8 674 14035 0 0 0.00545816471080279 0.999430321156448 0.998877815823723 0.99975402204924 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 12.2229935310233 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 11 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.2442G>A fbiC_c.2442G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.2475A>G fbiC_c.2475A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.2487C>T fbiC_c.2487C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.24G>A fbiC_c.24G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 29 674 14014 0 0 0.00545816471080279 0.997934914192124 0.997035528243125 0.998616556898061 0 0 0.119444869069502 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.82792229113908 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 44 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.2508C>T fbiC_c.2508C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.2517C>T fbiC_c.2517C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.534232413570953 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.2526C>G fbiC_c.2526C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.2532G>T fbiC_c.2532G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 50.4845768710802 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.2568C>T fbiC_c.2568C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.297G>A fbiC_c.297G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.321C>T fbiC_c.321C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.534232413570953 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.-32A>G fbiC_c.-32A>G 2 upstream_gene_variant 1302899 1 6 0 6 3 46 671 13997 0.00445103857566765 0.00091885344774779 0.0129522747681396 0.996724346649576 0.995633127605288 0.997600842197873 0.0612244897959183 0.0128084213182788 0.168658900702301 0 0 0.4592581264399 0 0 0.0770618270519006 0 0 17.7505394366091 1 619 1319 False False 1.36042895094926 0.269953283157788 4.24916842774955 0 0 0.00548250081433617 0.996724346649576 0.995633127605288 0.997600842197873 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 15 213 4719 0.00467289719626168 0.000118300515887328 0.0257593138532706 0.996831432192648 0.99477930587339 0.998225525582608 0.0625 0.00158111172276588 0.302320738434531 0 0 0.707598226178713 0 0 0.218019360910534 0 0 53.8464694749122 1 279.5 572 False False 0 0 0 0 0 0 0 1.47699530516431 0.0349229478397681 9.68838732645631 0 0 0.0171695765109405 0.996831432192648 0.99477930587339 0.998225525582608 431 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC c.-32A>T fbiC_c.-32A>T 2 upstream_gene_variant 1302899 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1280 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 556 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC c.-33G>A fbiC_c.-33G>A 2 upstream_gene_variant 1302898 1 1 0 1 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 802.34555512305 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC c.34C>T fbiC_c.34C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.396C>T fbiC_c.396C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 43 671 14000 0.00445103857566765 0.00091885344774779 0.0129522747681396 0.996937976215908 0.995877666044285 0.997783138807742 0.0652173913043478 0.0136567719134455 0.178964388872751 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.45565452465948 0.288120413198783 4.56622520218782 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 31 214 4703 0 0 0.0170900343744659 0.993451626531474 0.990717879050874 0.995546488337283 0 0 0.11218874692237 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.80061071595361 NA NA NA NA NA NA 40 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.399C>T fbiC_c.399C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.-44T>C fbiC_c.-44T>C 2 upstream_gene_variant 1302887 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC c.-46G>C fbiC_c.-46G>C 2 upstream_gene_variant 1302885 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1286 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC c.-48C>T fbiC_c.-48C>T 2 upstream_gene_variant 1302883 1 3 0 3 0 6 674 14037 0 0 0.00545816471080279 0.999572740867336 0.999070270474308 0.999843187804675 0 0 0.4592581264399 0 0 0.707598226178713 0 0 0.4592581264399 0 0 50.4737503704545 1 169 1319 False False 0 0 17.7219093583043 0 0 0.00545816471080279 0.999572740867336 0.999070270474308 0.999843187804675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 5 214 4729 0 0 0.0170900343744659 0.998943810730883 0.997536942130593 0.999656972101492 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 53.7066553001796 1 83 572 False False 0 0 0 0 0 0 0 0 0 24.2508634033673 0 0 0.0170900343744659 0.998943810730883 0.997536942130593 0.999656972101492 10 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC c.495G>A fbiC_c.495G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.498C>A fbiC_c.498C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 11 674 14032 0 0 0.00545816471080279 0.999216691590116 0.998598878125098 0.999608912470572 0 0 0.284914152918154 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.31593780715244 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 11 214 4723 0 0 0.0170900343744659 0.997676383607942 0.995846220600476 0.998839506172504 0 0 0.284914152918154 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.85892377666813 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.498C>T fbiC_c.498C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.-4C>T fbiC_c.-4C>T 2 upstream_gene_variant 1302927 1 10 0 10 0 11 674 14032 0 0 0.00545816471080279 0.999216691590116 0.998598878125098 0.999608912470572 0 0 0.284914152918154 0 0 0.30849710781876 0 0 0.284914152918154 0 0 9.30709109293613 1 169 1319 False False 0 0 8.31593780715244 0 0 0.00545816471080279 0.999216691590116 0.998598878125098 0.999608912470572 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 0 10 214 4724 0 0 0.0170900343744659 0.997887621461766 0.996118702879007 0.998986582156994 0 0 0.30849710781876 0 0 0.336267116879942 0 0 0.30849710781876 0 0 11.2582646420503 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 9.91563904469691 0 0 0.0170900343744659 0.997887621461766 0.996118702879007 0.998986582156994 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC c.519C>T fbiC_c.519C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.525C>G fbiC_c.525C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.546G>C fbiC_c.546G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 50.4845768710802 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 118.033875066473 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.57C>A fbiC_c.57C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.-58A>C fbiC_c.-58A>C 2 upstream_gene_variant 1302873 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC c.-58A>G fbiC_c.-58A>G 2 upstream_gene_variant 1302873 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 4 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC c.624G>T fbiC_c.624G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 1 672 14042 0.0029673590504451 0.000359563182310977 0.0106776554748576 0.999928790144556 0.999603308654684 0.999998197124178 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 41.7916666666666 2.17098038345829 2418.88338333889 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.-64T>C fbiC_c.-64T>C 2 upstream_gene_variant 1302867 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC c.690C>T fbiC_c.690C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 118.033875066473 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.714G>A fbiC_c.714G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 50.4845768710802 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 214 4731 0 0 0.0170900343744659 0.999366286438529 0.998149147855346 0.999869293957204 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 53.7295049630073 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.741C>T fbiC_c.741C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.750G>A fbiC_c.750G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.-76A>G fbiC_c.-76A>G 2 upstream_gene_variant 1302855 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC c.771C>T fbiC_c.771C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.-77T>C fbiC_c.-77T>C 2 upstream_gene_variant 1302854 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC c.810C>T fbiC_c.810C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.813C>T fbiC_c.813C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.819G>A fbiC_c.819G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.819G>T fbiC_c.819G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.-81C>A fbiC_c.-81C>A 2 upstream_gene_variant 1302850 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC c.822A>G fbiC_c.822A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.861C>T fbiC_c.861C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.-87C>T fbiC_c.-87C>T 2 upstream_gene_variant 1302844 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC c.-89_-88insACTGTTGCGC fbiC_c.-89_-88insACTGTTGCGC 2 upstream_gene_variant 1302842 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC c.-90C>T fbiC_c.-90C>T 2 upstream_gene_variant 1302841 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC c.939T>C fbiC_c.939T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC c.967C>T fbiC_c.967C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 36 674 14007 0 0 0.00545816471080279 0.997436445204016 0.996452708846449 0.998203891572429 0 0 0.0973937559144919 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.248665525849 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 21 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fbiC LoF fbiC_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 4 0 4 3 5 671 14038 0.00445103857566765 0.00091885344774779 0.0129522747681396 0.99964395072278 0.999169297020829 0.999884381985141 0.375 0.0852334141372535 0.755136783633448 0 0 0.602364635616474 0 0 0.521823750104981 0 0 31.7230248378734 1 619 1319 False False 12.55260804769 1.94429049070268 64.6467443536221 0 0 0.00548250081433617 0.99964395072278 0.999169297020829 0.999884381985141 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 2 3 212 4731 0.00934579439252336 0.00113382977970066 0.0333506066446319 0.999366286438529 0.998149147855346 0.999869293957204 0.4 0.0527449505263169 0.853367200365326 0 0 0.707598226178713 0 0 0.707598226178713 0 0 54.2414574664348 1 83 572 False False 0 0 0 0 0 0 0 14.877358490566 1.23435854820346 130.056444856248 0 0 0.0172498625165958 0.999366286438529 0.998149147855346 0.999869293957204 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Ala11Val fbiC_p.Ala11Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 674 14038 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 22.7684048554448 1 169 1319 False False 0 0 22.7684048554448 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 214 4729 0 0 0.0170900343744659 0.998943810730883 0.997536942130593 0.999656972101492 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 24.2508634033673 1 83 572 False False 0 0 0 0 0 0 0 0 0 24.2508634033673 0 0 0.0170900343744659 0.998943810730883 0.997536942130593 0.999656972101492 3 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Ala143Val fbiC_p.Ala143Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Ala333Val fbiC_p.Ala333Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 11 0 11 0 13 674 14030 0 0 0.00545816471080279 0.999074271879228 0.998417496974718 0.999506999611345 0 0 0.24705263800047 0 0 0.284914152918154 0 0 0.24705263800047 0 0 8.31475248610209 1 619 1319 False False 0 0 6.84763051410409 0 0 0.00545816471080279 0.999074271879228 0.998417496974718 0.999506999611345 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 0 12 214 4722 0 0 0.0170900343744659 0.997465145754119 0.995576310623027 0.998689539208118 0 0 0.264648469397051 0 0 0.30849710781876 0 0 0.264648469397051 0 0 9.91144393921099 1 83 572 False False 0 0 0 0 0 0 0 0 0 7.99776745063011 0 0 0.0170900343744659 0.997465145754119 0.995576310623027 0.998689539208118 8 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Ala349Val fbiC_p.Ala349Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1306 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Ala378Glu fbiC_p.Ala378Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Ala404Pro fbiC_p.Ala404Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Ala418Glu fbiC_p.Ala418Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Ala45Thr fbiC_p.Ala45Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Ala469Pro fbiC_p.Ala469Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Ala487fs fbiC_p.Ala487fs 2 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1290 1319 False False Inf 0.534232413570953 Inf 0 0 0.00546625270429624 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Ala505Thr fbiC_p.Ala505Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 19 0 19 2 33 672 14010 0.0029673590504451 0.000359563182310977 0.0106776554748576 0.997650074770348 0.996701399645688 0.998381884434533 0.0571428571428571 0.00699676362830951 0.191571406345239 0 0 0.176466911806965 0 0 0.105762810074579 0 0 4.47881384364881 1 619 1319 False False 1.26352813852813 0.146610498731941 4.95820162057412 0 0 0.00547436470313033 0.997650074770348 0.996701399645688 0.998381884434533 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 103 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Ala520Ser fbiC_p.Ala520Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Ala524Gly fbiC_p.Ala524Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 0 8 674 14035 0 0 0.00545816471080279 0.999430321156448 0.998877815823723 0.99975402204924 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 12.2229935310233 1 1043.5 1319 False False 0 0 12.2229935310233 0 0 0.00545816471080279 0.999430321156448 0.998877815823723 0.99975402204924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 11 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Ala574Val fbiC_p.Ala574Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Ala576Val fbiC_p.Ala576Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 118.033875066473 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Ala585Gly fbiC_p.Ala585Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Ala594Ser fbiC_p.Ala594Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 50.4845768710802 1 619 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Ala620Thr fbiC_p.Ala620Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 674 14037 0 0 0.00545816471080279 0.999572740867336 0.999070270474308 0.999843187804675 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 17.7219093583043 1 169 1319 False False 0 0 17.7219093583043 0 0 0.00545816471080279 0.999572740867336 0.999070270474308 0.999843187804675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 214 4730 0 0 0.0170900343744659 0.999155048584706 0.997838014616212 0.999769732715123 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 33.6387430781262 1 83 572 False False 0 0 0 0 0 0 0 0 0 33.6387430781262 0 0 0.0170900343744659 0.999155048584706 0.997838014616212 0.999769732715123 3 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Ala623Val fbiC_p.Ala623Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.534232413570953 Inf 0.0457973771828497 55 1319 False False Inf 0.534232413570953 Inf 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Ala639fs fbiC_p.Ala639fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1308 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Ala63Thr fbiC_p.Ala63Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Ala659Val fbiC_p.Ala659Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Ala73Ser fbiC_p.Ala73Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 3 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Ala754Val fbiC_p.Ala754Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 111.092568149139 1 169 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Ala756Val fbiC_p.Ala756Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Ala852Thr fbiC_p.Ala852Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Ala852Val fbiC_p.Ala852Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1278 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Ala855fs fbiC_p.Ala855fs 2 frameshift (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 50.4845768710802 1 619 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 118.033875066473 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 129 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Ala856fs fbiC_p.Ala856fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 2 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Arg134Leu fbiC_p.Arg134Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1316 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Arg243Gly fbiC_p.Arg243Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1291 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Arg330Cys fbiC_p.Arg330Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1314 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 568 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Arg426Cys fbiC_p.Arg426Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Arg446Leu fbiC_p.Arg446Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Arg536Leu fbiC_p.Arg536Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1301 1319 False False Inf 0.534232413570953 Inf 0 0 0.00546625270429624 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 213 4734 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 563 572 False False 0 0 0 0 0 0 0 Inf 0.56721266938512 Inf 0 0 0.0171695765109405 1 0.999221072542716 1 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Arg64Gln fbiC_p.Arg64Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Arg66Ser fbiC_p.Arg66Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1282 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Arg727Cys fbiC_p.Arg727Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Arg7Leu fbiC_p.Arg7Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Arg99Trp fbiC_p.Arg99Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 2 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Asn549Asp fbiC_p.Asn549Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.534232413570953 Inf 0.0457973771828497 55 1319 False False Inf 0.534232413570953 Inf 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Asp100Glu fbiC_p.Asp100Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 11 2 9 7 9 667 14034 0.0103857566765578 0.00418552311154975 0.0212809513555928 0.999359111301004 0.998783743811125 0.999706904333134 0.4375 0.197534140532667 0.701223100916822 0.181818181818181 0.0228311982999596 0.517755852360172 0.181818181818181 0.0228311982999596 0.517755852360172 4.67566216891554 0.490546573657885 22.6478500584684 0.0865317515832052 86 1319 False False 16.3648175912043 5.15925335804262 49.5629861220727 0.00298953662182361 0.00036225202497941 0.0107571469644069 0.999359111301004 0.998783743811125 0.999706904333134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Asp130Glu fbiC_p.Asp130Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1293 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 561 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Asp168Glu fbiC_p.Asp168Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 50.4845768710802 1 619 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Asp235Gly fbiC_p.Asp235Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Asp272Gly fbiC_p.Asp272Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 674 14039 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 111.084736596165 1 619 1319 False False 0 0 31.5916386345298 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Asp313Gly fbiC_p.Asp313Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 673 14042 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999928790144556 0.999603308654684 0.999998197124178 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1294 1319 False False 20.8647845468053 0.265412371331172 1613.44310281692 0 0 0.00546625270429624 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Asp375Asn fbiC_p.Asp375Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 7 674 14036 0 0 0.00545816471080279 0.999501531011892 0.998973234784508 0.999799566877855 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 14.476435679416 1 169 1319 False False 0 0 14.476435679416 0 0 0.00545816471080279 0.999501531011892 0.998973234784508 0.999799566877855 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Asp427His fbiC_p.Asp427His 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 50.4845768710802 1 619 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Asp454Asn fbiC_p.Asp454Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1284 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Asp472Ala fbiC_p.Asp472Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Asp521Gly fbiC_p.Asp521Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Asp542Glu fbiC_p.Asp542Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Asp616Gly fbiC_p.Asp616Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 674 14038 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 22.7684048554448 1 169 1319 False False 0 0 22.7684048554448 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Cys59Tyr fbiC_p.Cys59Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1292 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 560 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 12 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Cys600Arg fbiC_p.Cys600Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Gln117Pro fbiC_p.Gln117Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Glu265Asp fbiC_p.Glu265Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Glu269Gly fbiC_p.Glu269Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Glu299Val fbiC_p.Glu299Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Glu526Lys fbiC_p.Glu526Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Glu54Gly fbiC_p.Glu54Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Glu598Asp fbiC_p.Glu598Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Glu801Gly fbiC_p.Glu801Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Glu832Gly fbiC_p.Glu832Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Gly135Ser fbiC_p.Gly135Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Gly262Asp fbiC_p.Gly262Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1303 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Gly285Glu fbiC_p.Gly285Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Gly340Asp fbiC_p.Gly340Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Gly385Asp fbiC_p.Gly385Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.534232413570953 Inf 0.0457973771828497 55 1319 False False Inf 0.534232413570953 Inf 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Gly385Cys fbiC_p.Gly385Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Gly508Ser fbiC_p.Gly508Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 0 8 674 14035 0 0 0.00545816471080279 0.999430321156448 0.998877815823723 0.99975402204924 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 12.2229935310233 1 1043.5 1319 False False 0 0 12.2229935310233 0 0 0.00545816471080279 0.999430321156448 0.998877815823723 0.99975402204924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 0 8 214 4726 0 0 0.0170900343744659 0.998310097169412 0.996672947522823 0.999270146456405 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 13.0211752369257 1 83 572 False False 0 0 0 0 0 0 0 0 0 13.0211752369257 0 0 0.0170900343744659 0.998310097169412 0.996672947522823 0.999270146456405 9 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Gly522Arg fbiC_p.Gly522Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 674 14039 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 31.5916386345298 1 619 1319 False False 0 0 31.5916386345298 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Gly683Ala fbiC_p.Gly683Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Gly711Ala fbiC_p.Gly711Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Gly839Ala fbiC_p.Gly839Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 674 14038 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 22.7684048554448 1 169 1319 False False 0 0 22.7684048554448 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Gly839Asp fbiC_p.Gly839Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 674 14039 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 31.5916386345298 1 619 1319 False False 0 0 31.5916386345298 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Gly839Ser fbiC_p.Gly839Ser 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1281 1319 False False Inf 0.534232413570953 Inf 0 0 0.00546625270429624 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.His103Arg fbiC_p.His103Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 50.4845768710802 1 619 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.His103Gln fbiC_p.His103Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.His300Tyr fbiC_p.His300Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.His592Arg fbiC_p.His592Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1315 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 569 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Ile406Phe fbiC_p.Ile406Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Ile453Val fbiC_p.Ile453Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Ile491Val fbiC_p.Ile491Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1304 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Ile693Val fbiC_p.Ile693Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1311 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 566 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 6 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Ile781Val fbiC_p.Ile781Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 802.34555512305 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Ile816Met fbiC_p.Ile816Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Leu114Arg fbiC_p.Leu114Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1305 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 564 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 2 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Leu162Val fbiC_p.Leu162Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.534232413570953 Inf 0.0457973771828497 55 1319 False False Inf 0.534232413570953 Inf 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Leu517_Ala518del fbiC_p.Leu517_Ala518del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Leu517Ile fbiC_p.Leu517Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Leu647Arg fbiC_p.Leu647Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1285 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Lys113Thr fbiC_p.Lys113Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Lys622Arg fbiC_p.Lys622Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1302 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Lys682Arg fbiC_p.Lys682Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Met196Val fbiC_p.Met196Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Met211Ile fbiC_p.Met211Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1296 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Met628Ile fbiC_p.Met628Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Met709Ile fbiC_p.Met709Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Met812Ile fbiC_p.Met812Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Phe306Leu fbiC_p.Phe306Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Phe470Leu fbiC_p.Phe470Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Phe470Val fbiC_p.Phe470Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Phe554Ser fbiC_p.Phe554Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Pro125His fbiC_p.Pro125His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Pro18Leu fbiC_p.Pro18Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.534232413570953 Inf 0.0457973771828497 55 1319 False False Inf 0.534232413570953 Inf 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Pro234Leu fbiC_p.Pro234Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Pro334Ala fbiC_p.Pro334Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1317 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Pro359Ser fbiC_p.Pro359Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Pro362fs fbiC_p.Pro362fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1312 1319 False False Inf 0.534232413570953 Inf 0 0 0.00546625270429624 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 213 4734 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 567 572 False False 0 0 0 0 0 0 0 Inf 0.56721266938512 Inf 0 0 0.0171695765109405 1 0.999221072542716 1 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Pro370Arg fbiC_p.Pro370Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Pro420Leu fbiC_p.Pro420Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Pro420Ser fbiC_p.Pro420Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Pro438Leu fbiC_p.Pro438Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Pro761Leu fbiC_p.Pro761Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Pro843Ala fbiC_p.Pro843Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Ser172Cys fbiC_p.Ser172Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 111.092568149139 1 169 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Ser219Ala fbiC_p.Ser219Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Ser443fs fbiC_p.Ser443fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1309 1319 False False Inf 0.534232413570953 Inf 0 0 0.00546625270429624 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 213 4734 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 565 572 False False 0 0 0 0 0 0 0 Inf 0.56721266938512 Inf 0 0 0.0171695765109405 1 0.999221072542716 1 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Ser645Gly fbiC_p.Ser645Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1299 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Ser762Asn fbiC_p.Ser762Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 674 14039 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 31.5916386345298 1 619 1319 False False 0 0 31.5916386345298 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 11 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Ser782Leu fbiC_p.Ser782Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Ter857Trpext*? fbiC_p.Ter857Trpext*? 2 stop_lost (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Thr273Ala fbiC_p.Thr273Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 20 0 20 0 23 674 14020 0 0 0.00545816471080279 0.998362173324788 0.99754346318125 0.99896148392623 0 0 0.148185128915224 0 0 0.168433470983085 0 0 0.148185128915224 0 0 4.22409733297897 1 619 1319 False False 0 0 3.62838604932729 0 0 0.00545816471080279 0.998362173324788 0.99754346318125 0.99896148392623 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 5 214 4729 0 0 0.0170900343744659 0.998943810730883 0.997536942130593 0.999656972101492 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 53.7066553001796 1 83 572 False False 0 0 0 0 0 0 0 0 0 24.2508634033673 0 0 0.0170900343744659 0.998943810730883 0.997536942130593 0.999656972101492 137 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Thr38Lys fbiC_p.Thr38Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Thr455Ile fbiC_p.Thr455Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Thr545Ser fbiC_p.Thr545Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Thr663Asn fbiC_p.Thr663Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1283 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Thr681Ile fbiC_p.Thr681Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 672 14043 0.0029673590504451 0.000359563182310977 0.0106776554748576 1 0.999737349925893 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 3.91661217545325 Inf 0.00209443020141736 16.5 1319 False False Inf 3.91661217545325 Inf 0.0029673590504451 0.000359563182310977 0.0106776554748576 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 212 4734 0.00934579439252336 0.00113382977970066 0.0333506066446319 1 0.999221072542716 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 4.16553496523236 Inf 0.00186218050380108 11.5 572 False False 0 0 0 0 0 0 0 Inf 4.16553496523236 Inf 0.00934579439252336 0.00113382977970066 0.0333506066446319 1 0.999221072542716 1 13 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Thr687Met fbiC_p.Thr687Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1289 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 559 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 4 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Thr696Asn fbiC_p.Thr696Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1287 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 557 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Thr707Met fbiC_p.Thr707Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Trp405Cys fbiC_p.Trp405Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1298 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 562 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Trp678Gly fbiC_p.Trp678Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 161 2 159 2 163 672 13880 0.0029673590504451 0.000359563182310977 0.0106776554748576 0.988392793562629 0.986480823244168 0.990098160371604 0.0121212121212121 0.00147132072550042 0.0430982005753911 0.0124223602484472 0.00150796187339616 0.0441515923196379 0.0121212121212121 0.00147132072550042 0.0430982005753911 0.259808325846061 0.0311351928515813 0.957933897176343 0.0358130677191341 26 1319 False False 0.253432661408121 0.0303752295521031 0.934028872601833 0.0029673590504451 0.000359563182310977 0.0106776554748576 0.988392793562629 0.986480823244168 0.990098160371604 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 8 214 4726 0 0 0.0170900343744659 0.998310097169412 0.996672947522823 0.999270146456405 0 0 0.369416647552819 0 0 0.409616397225003 0 0 0.369416647552819 0 0 15.4173537499273 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 13.0211752369257 0 0 0.0170900343744659 0.998310097169412 0.996672947522823 0.999270146456405 303 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Tyr86Cys fbiC_p.Tyr86Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Val365Ile fbiC_p.Val365Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1300 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Val37Ala fbiC_p.Val37Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Val41Met fbiC_p.Val41Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 7 674 14036 0 0 0.00545816471080279 0.999501531011892 0.998973234784508 0.999799566877855 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 17.720647938943 1 619 1319 False False 0 0 14.476435679416 0 0 0.00545816471080279 0.999501531011892 0.998973234784508 0.999799566877855 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 6 214 4728 0 0 0.0170900343744659 0.998732572877059 0.997243401195562 0.999534739052189 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 24.2455018638228 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 18.8747365567989 0 0 0.0170900343744659 0.998732572877059 0.997243401195562 0.999534739052189 9 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Val547Ala fbiC_p.Val547Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Val581Leu fbiC_p.Val581Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 0 8 674 14035 0 0 0.00545816471080279 0.999430321156448 0.998877815823723 0.99975402204924 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 12.2229935310233 1 1043.5 1319 False False 0 0 12.2229935310233 0 0 0.00545816471080279 0.999430321156448 0.998877815823723 0.99975402204924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 35 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Val621Ile fbiC_p.Val621Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1297 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Val713Leu fbiC_p.Val713Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 674 14039 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1295 1319 False False 0 0 31.5916386345298 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Val725Ala fbiC_p.Val725Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Val745Met fbiC_p.Val745Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fbiC p.Val94Ala fbiC_p.Val94Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1279 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 c.1000C>A fgd1_c.1000C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fgd1 c.1002A>C fgd1_c.1002A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fgd1 c.135C>T fgd1_c.135C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 50.4845768710802 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fgd1 c.138C>T fgd1_c.138C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fgd1 c.153C>T fgd1_c.153C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 118.033875066473 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fgd1 c.-15G>A fgd1_c.-15G>A 2 upstream_gene_variant 490768 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 c.16C>T fgd1_c.16C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fgd1 c.18A>C fgd1_c.18A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.534232413570953 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 213 4734 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.56721266938512 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fgd1 c.195C>G fgd1_c.195C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 50.4845768710802 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 214 4731 0 0 0.0170900343744659 0.999366286438529 0.998149147855346 0.999869293957204 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 53.7295049630073 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fgd1 c.195C>T fgd1_c.195C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 118.033875066473 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fgd1 c.-20C>T fgd1_c.-20C>T 2 upstream_gene_variant 490763 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1211 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 c.228C>T fgd1_c.228C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fgd1 c.234C>T fgd1_c.234C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fgd1 c.246C>T fgd1_c.246C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 674 14039 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.5916386345298 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fgd1 c.255C>T fgd1_c.255C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fgd1 c.-26T>A fgd1_c.-26T>A 2 upstream_gene_variant 490757 1 7 0 7 0 7 674 14036 0 0 0.00545816471080279 0.999501531011892 0.998973234784508 0.999799566877855 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 14.476435679416 1 169 1319 False False 0 0 14.476435679416 0 0 0.00545816471080279 0.999501531011892 0.998973234784508 0.999799566877855 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 7 214 4727 0 0 0.0170900343744659 0.998521335023236 0.996955773035796 0.999405299839924 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 15.4206152522212 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 15.4206152522212 0 0 0.0170900343744659 0.998521335023236 0.996955773035796 0.999405299839924 8 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 c.-27T>G fgd1_c.-27T>G 2 upstream_gene_variant 490756 1 15 1 14 1 14 673 14029 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999003062023784 0.998327872643959 0.99945486094574 0.0666666666666666 0.0016864302413527 0.319484566578303 0.0666666666666666 0.0016864302413527 0.319484566578303 0.0666666666666666 0.0016864302413527 0.319484566578303 1.48896200382084 0.0351621942781286 9.81598063465205 0.505165154239908 132 1319 False False 1.48896200382084 0.0351621942781286 9.81598063465205 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999003062023784 0.998327872643959 0.99945486094574 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 214 4731 0 0 0.0170900343744659 0.999366286438529 0.998149147855346 0.999869293957204 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 53.7295049630073 1 83 572 False False 0 0 0 0 0 0 0 0 0 53.7295049630073 0 0 0.0170900343744659 0.999366286438529 0.998149147855346 0.999869293957204 31 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 c.285C>T fgd1_c.285C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fgd1 c.286C>T fgd1_c.286C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fgd1 c.291C>T fgd1_c.291C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fgd1 c.297C>T fgd1_c.297C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fgd1 c.-30G>A fgd1_c.-30G>A 2 upstream_gene_variant 490753 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 c.318C>T fgd1_c.318C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fgd1 c.-31C>G fgd1_c.-31C>G 2 upstream_gene_variant 490752 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 c.342C>T fgd1_c.342C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fgd1 c.-36_-35insG fgd1_c.-36_-35insG 2 upstream_gene_variant 490747 NA 0 0 0 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1202 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 530 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 c.360C>T fgd1_c.360C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 37 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fgd1 c.-38G>A fgd1_c.-38G>A 2 upstream_gene_variant 490745 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 c.456C>T fgd1_c.456C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fgd1 c.465C>T fgd1_c.465C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 63 673 13980 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.995513779107028 0.994263774777531 0.996550994260984 0.015625 0.000395512514050664 0.0840103264343536 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.329724757659378 0.00821006305294297 1.91168141134532 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 7 214 4727 0 0 0.0170900343744659 0.998521335023236 0.996955773035796 0.999405299839924 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 15.4206152522212 NA NA NA NA NA NA 678 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fgd1 c.48A>G fgd1_c.48A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fgd1 c.-4A>G fgd1_c.-4A>G 2 upstream_gene_variant 490779 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 c.504G>C fgd1_c.504G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 10 674 14033 0 0 0.00545816471080279 0.99928790144556 0.998690816610614 0.99965846992849 0 0 0.30849710781876 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.30775405122037 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fgd1 c.513C>G fgd1_c.513C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fgd1 c.51G>A fgd1_c.51G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 50.4845768710802 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 214 4731 0 0 0.0170900343744659 0.999366286438529 0.998149147855346 0.999869293957204 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 53.7295049630073 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fgd1 c.534C>T fgd1_c.534C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fgd1 c.537G>T fgd1_c.537G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fgd1 c.543G>A fgd1_c.543G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fgd1 c.546C>T fgd1_c.546C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fgd1 c.54C>A fgd1_c.54C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fgd1 c.552C>T fgd1_c.552C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 7 674 14036 0 0 0.00545816471080279 0.999501531011892 0.998973234784508 0.999799566877855 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 14.476435679416 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 6 214 4728 0 0 0.0170900343744659 0.998732572877059 0.997243401195562 0.999534739052189 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 18.8747365567989 NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fgd1 c.555C>G fgd1_c.555C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fgd1 c.567T>C fgd1_c.567T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 50.4845768710802 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 14 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fgd1 c.606C>T fgd1_c.606C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fgd1 c.60C>T fgd1_c.60C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fgd1 c.619C>T fgd1_c.619C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 118.033875066473 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fgd1 c.666C>T fgd1_c.666C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 50.4845768710802 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 31 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fgd1 c.66A>G fgd1_c.66A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fgd1 c.741G>T fgd1_c.741G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 673 14042 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999928790144556 0.999603308654684 0.999998197124178 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 20.8647845468053 0.265412371331172 1613.44310281692 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 213 4734 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.56721266938512 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fgd1 c.750G>A fgd1_c.750G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fgd1 c.750G>T fgd1_c.750G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fgd1 c.774G>A fgd1_c.774G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 34 673 14009 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.997578864914904 0.996618334442602 0.998322728693492 0.0285714285714285 0.000723104376338095 0.149172079656431 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.612227952102089 0.0150434917428466 3.6611263950972 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 83 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fgd1 c.786C>T fgd1_c.786C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fgd1 c.816C>T fgd1_c.816C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fgd1 c.837G>A fgd1_c.837G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fgd1 c.843C>G fgd1_c.843C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 50.4845768710802 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fgd1 c.849C>T fgd1_c.849C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fgd1 c.870C>T fgd1_c.870C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fgd1 c.906A>G fgd1_c.906A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fgd1 c.915G>A fgd1_c.915G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fgd1 c.960T>C fgd1_c.960T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 476 8110 198 5933 0.706231454005934 0.670252016796689 0.74039350870409 0.422488072349213 0.414299540466742 0.430708736224756 0.0554390868856277 0.0506920471579004 0.0604905479982189 NA NA NA NA NA NA NA NA NA NA NA NA False True 1.75871414515064 1.48165813138606 2.09363157086418 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 178 3782 36 952 0.831775700934579 0.774793432728233 0.879309667091269 0.201098436839881 0.189761985468608 0.212804728987264 0.0449494949494949 0.03870798960156 0.0518730053046339 NA NA NA NA NA NA NA NA NA NA NA NA False True 1 1 1 0 0 0 0 1.24460896644926 0.859044724258956 1.84700659417805 NA NA NA NA NA NA 19132 5) Not assoc w R Now listed Silent mutation no 0 +Clofazimine fgd1 c.969C>G fgd1_c.969C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fgd1 c.982C>T fgd1_c.982C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine fgd1 deletion fgd1_deletion 2 feature_ablation (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1198 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 526 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 18 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 LoF fgd1_LoF 2 LoF (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1318 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 571 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.Ala10Val fgd1_p.Ala10Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.Ala188Thr fgd1_p.Ala188Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1207 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.Ala216Gly fgd1_p.Ala216Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.Ala293Val fgd1_p.Ala293Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.Ala2Val fgd1_p.Ala2Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 50.4845768710802 1 619 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 3 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.Ala35Val fgd1_p.Ala35Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 674 14039 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 31.5916386345298 1 619 1319 False False 0 0 31.5916386345298 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.Arg187His fgd1_p.Arg187His 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 5 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.Arg18Cys fgd1_p.Arg18Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.534232413570953 Inf 0.0457973771828497 55 1319 False False Inf 0.534232413570953 Inf 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.Arg212Leu fgd1_p.Arg212Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.Arg45Cys fgd1_p.Arg45Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 674 14038 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 22.7684048554448 1 169 1319 False False 0 0 22.7684048554448 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.Arg64Ser fgd1_p.Arg64Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 30 0 30 9 188 665 13855 0.0133531157270029 0.0061235862397289 0.0251964837714516 0.986612547176529 0.984571974579922 0.988447624555075 0.0456852791878172 0.021100082292359 0.0849508156240029 0 0 0.115703308222027 0 0 0.0194304466268233 0 0 2.73344143654205 0.401188154492838 126 1319 False False 0.99740041593345 0.447056900295058 1.94604132090258 0 0 0.00553182991601401 0.986612547176529 0.984571974579922 0.988447624555075 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 118.033875066473 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 443 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.Asn66Ser fgd1_p.Asn66Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.Asp190Glu fgd1_p.Asp190Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.534232413570953 Inf 0.0457973771828497 55 1319 False False Inf 0.534232413570953 Inf 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.Asp273Gly fgd1_p.Asp273Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.Asp33Gly fgd1_p.Asp33Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.Gln279Pro fgd1_p.Gln279Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1209 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.Gln47Leu fgd1_p.Gln47Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.Glu119Asp fgd1_p.Glu119Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 674 14039 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 50.4809680276667 1 619 1319 False False 0 0 31.5916386345298 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 118.033875066473 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.Glu119Lys fgd1_p.Glu119Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1210 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.Glu127Lys fgd1_p.Glu127Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.Glu19Asp fgd1_p.Glu19Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1205 1319 False False Inf 0.534232413570953 Inf 0 0 0.00546625270429624 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.Glu240Gly fgd1_p.Glu240Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.Glu269Lys fgd1_p.Glu269Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1196 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.Gly137Glu fgd1_p.Gly137Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1206 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.Gly168Arg fgd1_p.Gly168Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.Gly169Asp fgd1_p.Gly169Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1203 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 531 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.Gly199Arg fgd1_p.Gly199Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 118.033875066473 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 6 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.Gly224Asp fgd1_p.Gly224Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1199 1319 False False Inf 0.534232413570953 Inf 0 0 0.00546625270429624 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 213 4734 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 527 572 False False 0 0 0 0 0 0 0 Inf 0.56721266938512 Inf 0 0 0.0171695765109405 1 0.999221072542716 1 3 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.Gly7Ser fgd1_p.Gly7Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.His260Pro fgd1_p.His260Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1212 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.His315Asp fgd1_p.His315Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.His315Tyr fgd1_p.His315Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.Ile229Thr fgd1_p.Ile229Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.Ile86Leu fgd1_p.Ile86Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.Leu323Phe fgd1_p.Leu323Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 9 674 14034 0 0 0.00545816471080279 0.999359111301004 0.998783743811125 0.999706904333134 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1204 1319 False False 0 0 10.5701597897411 0 0 0.00545816471080279 0.999359111301004 0.998783743811125 0.999706904333134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 9 214 4725 0 0 0.0170900343744659 0.998098859315589 0.996394124094466 0.999130320470377 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 532 572 False False 0 0 0 0 0 0 0 0 0 11.2606469033018 0 0 0.0170900343744659 0.998098859315589 0.996394124094466 0.999130320470377 54 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.Lys183Met fgd1_p.Lys183Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 5 673 14038 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.99964395072278 0.999169297020829 0.999884381985141 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.707598226178713 0 0 0.521823750104981 0 0 50.5527258238141 1 169 1319 False False 4.17176820208023 0.0880732176054642 37.3482568099296 0 0 0.00546625270429624 0.99964395072278 0.999169297020829 0.999884381985141 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 75 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.Lys183Thr fgd1_p.Lys183Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.Lys270Met fgd1_p.Lys270Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 23 1061 651 12982 0.0341246290801186 0.0217526829884331 0.0507653854389245 0.924446343373923 0.919951129722873 0.928764732824934 0.0212177121771217 0.0134966063486811 0.0316676920358095 NA NA NA 0 0 0.00347075790842108 NA NA NA NA 1201 1319 False True 0.432287888856555 0.2708099846181 0.658130496039881 0 0 0.00565045727133897 0.924446343373923 0.919951129722873 0.928764732824934 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 1 108 213 4626 0.00467289719626168 0.000118300515887328 0.0257593138532706 0.977186311787072 0.972521528508246 0.981248845703398 0.0091743119266055 0.000232246494352311 0.0500568230848124 NA NA NA 0 0 0.0335795502186544 NA NA NA NA 529 572 False True 1 1 1 0 0 0 0 0.201095461658841 0.0050252553401541 1.15715985486905 0 0 0.0171695765109405 0.977186311787072 0.972521528508246 0.981248845703398 3257 5) Not assoc w R New NotAwR yes 5 +Clofazimine fgd1 p.Lys296Arg fgd1_p.Lys296Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 8 674 14035 0 0 0.00545816471080279 0.999430321156448 0.998877815823723 0.99975402204924 0 0 0.369416647552819 0 0 0.602364635616474 0 0 0.369416647552819 0 0 31.5831608132764 1 169 1319 False False 0 0 12.2229935310233 0 0 0.00545816471080279 0.999430321156448 0.998877815823723 0.99975402204924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 214 4730 0 0 0.0170900343744659 0.999155048584706 0.997838014616212 0.999769732715123 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 53.7180800648943 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 33.6387430781262 0 0 0.0170900343744659 0.999155048584706 0.997838014616212 0.999769732715123 25 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.Lys296Glu fgd1_p.Lys296Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 10 674 14033 0 0 0.00545816471080279 0.99928790144556 0.998690816610614 0.99965846992849 0 0 0.30849710781876 NA NA NA 0 0 0.30849710781876 NA NA NA NA 1208 1319 False False 0 0 9.30775405122037 0 0 0.00545816471080279 0.99928790144556 0.998690816610614 0.99965846992849 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 59 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.Met93Thr fgd1_p.Met93Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 15 2 13 3 13 671 14030 0.00445103857566765 0.00091885344774779 0.0129522747681396 0.999074271879228 0.998417496974718 0.999506999611345 0.1875 0.0404737339059459 0.456456546231611 0.133333333333333 0.0165759134400836 0.404602696603372 0.133333333333333 0.0165759134400836 0.404602696603372 3.21678321678321 0.351692625146213 14.2509612734976 0.148223310413946 104 1319 False False 4.82517482517482 0.879700218775112 17.611758144679 0.00297176820208023 0.000360097752794557 0.0106934596481595 0.999074271879228 0.998417496974718 0.999506999611345 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 76 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.Phe90Ser fgd1_p.Phe90Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.Pro166Leu fgd1_p.Pro166Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.Pro171Thr fgd1_p.Pro171Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.Pro52Leu fgd1_p.Pro52Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.Ser54Pro fgd1_p.Ser54Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.Thr255Ala fgd1_p.Thr255Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 674 14039 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 50.4809680276667 1 619 1319 False False 0 0 31.5916386345298 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 12 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.Thr255Pro fgd1_p.Thr255Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.Tyr118Ser fgd1_p.Tyr118Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.Tyr163Cys fgd1_p.Tyr163Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 26 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.Tyr81His fgd1_p.Tyr81His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.Val136Met fgd1_p.Val136Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.Val170Met fgd1_p.Val170Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 10 555 664 13488 0.0148367952522255 0.00713714521247244 0.0271156851780873 0.960478530228583 0.95712370643038 0.963640795580537 0.0176991150442477 0.00851922054117641 0.0323078291621061 NA NA NA 0 0 0.00662458966179396 NA NA NA NA 1200 1319 False True 0.366004558775643 0.173707352189298 0.682658069607244 0 0 0.00554013786482473 0.960478530228583 0.95712370643038 0.963640795580537 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 10 518 204 4216 0.0467289719626168 0.0226327221083927 0.084255290187164 0.890578791719476 0.881338704316245 0.899333959048668 0.0189393939393939 0.00911861478863552 0.0345537339005541 NA NA NA 0 0 0.00709609190312476 NA NA NA NA 528 572 False True 1 1 1 0 0 0 0 0.398970398970399 0.187257917158948 0.755463536498923 0 0 0.0179202306624395 0.890578791719476 0.881338704316245 0.899333959048668 123 5) Not assoc w R New NotAwR yes 5 +Clofazimine fgd1 p.Val286Ala fgd1_p.Val286Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.Val294Ala fgd1_p.Val294Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 118.033875066473 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine fgd1 p.Val37Gly fgd1_p.Val37Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1197 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 c.1032C>G mmpL5_c.1032C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.1065G>A mmpL5_c.1065G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.1065G>T mmpL5_c.1065G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 13 154 661 13889 0.0192878338278931 0.0103089420811177 0.0327569506485166 0.989033682261625 0.987170487925532 0.990689852758521 0.0778443113772455 0.0420990110642515 0.129437488571714 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.77374894394561 0.91844086454307 3.14513283615274 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 4 213 4730 0.00467289719626168 0.000118300515887328 0.0257593138532706 0.999155048584706 0.997838014616212 0.999769732715123 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 5.55164319248826 0.112208269055498 56.3726785368423 NA NA NA NA NA NA 265 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.1068G>A mmpL5_c.1068G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 674 14039 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.5916386345298 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 214 4730 0 0 0.0170900343744659 0.999155048584706 0.997838014616212 0.999769732715123 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 33.6387430781262 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.1110C>T mmpL5_c.1110C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 50.4845768710802 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 214 4731 0 0 0.0170900343744659 0.999366286438529 0.998149147855346 0.999869293957204 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 53.7295049630073 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.1128G>A mmpL5_c.1128G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.1128G>T mmpL5_c.1128G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.1131G>C mmpL5_c.1131G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.1143G>A mmpL5_c.1143G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.1149G>C mmpL5_c.1149G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.1158C>T mmpL5_c.1158C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 50.4845768710802 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 118.033875066473 NA NA NA NA NA NA 14 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.1161C>G mmpL5_c.1161C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 15 674 14028 0 0 0.00545816471080279 0.99893185216834 0.998238863574905 0.999402046418979 0 0 0.218019360910534 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.81756381975128 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 63 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.1194G>C mmpL5_c.1194G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.1230C>T mmpL5_c.1230C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.1236G>T mmpL5_c.1236G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.1326G>C mmpL5_c.1326G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 11 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.1326G>T mmpL5_c.1326G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.1335C>T mmpL5_c.1335C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.135C>T mmpL5_c.135C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.1395C>A mmpL5_c.1395C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.1425G>C mmpL5_c.1425G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.1431G>C mmpL5_c.1431G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 50.4845768710802 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.1569G>A mmpL5_c.1569G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.1572G>A mmpL5_c.1572G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.1584C>T mmpL5_c.1584C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.1593C>T mmpL5_c.1593C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.1674G>A mmpL5_c.1674G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.1758C>T mmpL5_c.1758C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 674 14038 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 22.7684048554448 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.1785G>A mmpL5_c.1785G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.1791C>T mmpL5_c.1791C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.183G>A mmpL5_c.183G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 123 673 13920 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.991241187780388 0.989558349964183 0.992715431388909 0.00806451612903225 0.000204155028366464 0.0441130038852007 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.168158590946979 0.00422076759380696 0.95786387453489 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 7 214 4727 0 0 0.0170900343744659 0.998521335023236 0.996955773035796 0.999405299839924 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 15.4206152522212 NA NA NA NA NA NA 386 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.1875G>A mmpL5_c.1875G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.1896C>T mmpL5_c.1896C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 674 14038 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 22.7684048554448 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 5 214 4729 0 0 0.0170900343744659 0.998943810730883 0.997536942130593 0.999656972101492 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 24.2508634033673 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.189G>A mmpL5_c.189G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.18A>G mmpL5_c.18A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 674 14038 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 22.7684048554448 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 118.033875066473 NA NA NA NA NA NA 25 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.1926C>T mmpL5_c.1926C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.1941C>T mmpL5_c.1941C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 12 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.195C>T mmpL5_c.195C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.1A>G mmpL5_c.1A>G 1 initiator_codon_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 14 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.2070T>C mmpL5_c.2070T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 17 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.2079C>G mmpL5_c.2079C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 9 674 14034 0 0 0.00545816471080279 0.999359111301004 0.998783743811125 0.999706904333134 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 10.5701597897411 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 7 214 4727 0 0 0.0170900343744659 0.998521335023236 0.996955773035796 0.999405299839924 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 15.4206152522212 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.2115G>A mmpL5_c.2115G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.2145G>C mmpL5_c.2145G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.2214C>T mmpL5_c.2214C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.2241G>A mmpL5_c.2241G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.2250G>T mmpL5_c.2250G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.2265G>T mmpL5_c.2265G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 50.4845768710802 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.2286G>C mmpL5_c.2286G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.2289G>C mmpL5_c.2289G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.2325C>T mmpL5_c.2325C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.2340A>G mmpL5_c.2340A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.2400G>A mmpL5_c.2400G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.2412C>T mmpL5_c.2412C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.243G>A mmpL5_c.243G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.2475C>T mmpL5_c.2475C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 15 674 14028 0 0 0.00545816471080279 0.99893185216834 0.998238863574905 0.999402046418979 0 0 0.218019360910534 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.81756381975128 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 13 214 4721 0 0 0.0170900343744659 0.997253907900295 0.995308676874106 0.998537036545967 0 0 0.24705263800047 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 7.29113432294717 NA NA NA NA NA NA 26 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.2493G>A mmpL5_c.2493G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.24G>A mmpL5_c.24G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 22 674 14021 0 0 0.00545816471080279 0.998433383180232 0.997629078392245 0.999017957301543 0 0 0.154372512815574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.80746510250222 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.2502G>A mmpL5_c.2502G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 12 674 14031 0 0 0.00545816471080279 0.999145481734672 0.998507804828235 0.999558382465294 0 0 0.264648469397051 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.50790373059148 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 11 214 4723 0 0 0.0170900343744659 0.997676383607942 0.995846220600476 0.998839506172504 0 0 0.284914152918154 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.85892377666813 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.2527C>T mmpL5_c.2527C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.2529G>A mmpL5_c.2529G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.2557C>T mmpL5_c.2557C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.258C>T mmpL5_c.258C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.2634G>T mmpL5_c.2634G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.2658G>T mmpL5_c.2658G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 118.033875066473 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.2664T>C mmpL5_c.2664T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 674 14039 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.5916386345298 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.2715G>A mmpL5_c.2715G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.2721C>T mmpL5_c.2721C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.2730C>A mmpL5_c.2730C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.2739C>G mmpL5_c.2739C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.2742G>A mmpL5_c.2742G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.2751C>T mmpL5_c.2751C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.2757G>A mmpL5_c.2757G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 50.4845768710802 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.2760C>A mmpL5_c.2760C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.2766G>A mmpL5_c.2766G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 41 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.2781G>T mmpL5_c.2781G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 24 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.2838A>G mmpL5_c.2838A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.2871G>A mmpL5_c.2871G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.2886C>G mmpL5_c.2886C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.2889G>A mmpL5_c.2889G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 3 673 14040 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999786370433668 0.999375811939756 0.999955942280632 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 6.95393759286775 0.132268015542041 86.681794653799 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 77 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.291C>T mmpL5_c.291C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.303C>T mmpL5_c.303C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.30G>A mmpL5_c.30G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 50.4845768710802 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.354C>A mmpL5_c.354C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.375C>G mmpL5_c.375C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.3G>A mmpL5_c.3G>A 1 initiator_codon_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.414C>A mmpL5_c.414C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 50.4845768710802 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 214 4731 0 0 0.0170900343744659 0.999366286438529 0.998149147855346 0.999869293957204 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 53.7295049630073 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.462G>A mmpL5_c.462G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.465C>T mmpL5_c.465C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.480A>C mmpL5_c.480A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.495C>A mmpL5_c.495C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.504G>C mmpL5_c.504G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.507C>T mmpL5_c.507C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 20 673 14023 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.99857580289112 0.997801295863414 0.999129853182603 0.0476190476190476 0.00120488344836351 0.238159909936821 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.04182763744427 0.0250990535046755 6.53333076328476 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 5 214 4729 0 0 0.0170900343744659 0.998943810730883 0.997536942130593 0.999656972101492 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 24.2508634033673 NA NA NA NA NA NA 52 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.576G>A mmpL5_c.576G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.636C>T mmpL5_c.636C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.661C>T mmpL5_c.661C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 4 19 670 14024 0.0059347181008902 0.00161930788766713 0.0151250012595154 0.998647012746564 0.997887945605923 0.999185222909761 0.17391304347826 0.0495076453057934 0.387811889954797 NA NA NA NA NA NA NA NA NA NA NA NA False False 4.40659858601728 1.08701947457737 13.3109417269558 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 4 12 210 4722 0.0186915887850467 0.00511573452207981 0.0471638210086244 0.997465145754119 0.995576310623027 0.998689539208118 0.25 0.0726620382528822 0.523770819896127 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 7.49523809523809 1.74527824210191 24.9766938324011 NA NA NA NA NA NA 93 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.678C>A mmpL5_c.678C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.693C>T mmpL5_c.693C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.702G>A mmpL5_c.702G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.729C>G mmpL5_c.729C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.738C>G mmpL5_c.738C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.750C>T mmpL5_c.750C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.762G>A mmpL5_c.762G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.768T>C mmpL5_c.768T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.777G>A mmpL5_c.777G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 6 673 14037 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999572740867336 0.999070270474308 0.999843187804675 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.47622585438335 0.0754632221460442 28.7341429523688 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 2 213 4732 0.00467289719626168 0.000118300515887328 0.0257593138532706 0.999577524292353 0.998474714407054 0.999948832136202 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 11.1079812206572 0.187407717913085 213.598932938617 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.798C>T mmpL5_c.798C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.831C>T mmpL5_c.831C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.841C>T mmpL5_c.841C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.855C>T mmpL5_c.855C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 10 674 14033 0 0 0.00545816471080279 0.99928790144556 0.998690816610614 0.99965846992849 0 0 0.30849710781876 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.30775405122037 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 10 214 4724 0 0 0.0170900343744659 0.997887621461766 0.996118702879007 0.998986582156994 0 0 0.30849710781876 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.91563904469691 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.885G>A mmpL5_c.885G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.891G>A mmpL5_c.891G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.894G>A mmpL5_c.894G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 3 673 14040 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999786370433668 0.999375811939756 0.999955942280632 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 6.95393759286775 0.132268015542041 86.681794653799 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.894G>C mmpL5_c.894G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.909C>T mmpL5_c.909C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 6 673 14037 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999572740867336 0.999070270474308 0.999843187804675 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.47622585438335 0.0754632221460442 28.7341429523688 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 4 213 4730 0.00467289719626168 0.000118300515887328 0.0257593138532706 0.999155048584706 0.997838014616212 0.999769732715123 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 5.55164319248826 0.112208269055498 56.3726785368423 NA NA NA NA NA NA 100 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.972G>A mmpL5_c.972G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.984A>G mmpL5_c.984A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 c.9G>A mmpL5_c.9G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpL5 LoF mmpL5_LoF 1 LoF (see "Genomic_coordinates" sheet) 1 200 6 194 7 242 667 13801 0.0103857566765578 0.00418552311154975 0.0212809513555928 0.982767214982553 0.980476390832012 0.984854733521529 0.0281124497991967 0.0113758118815837 0.0570620779251752 0.03 0.0110874556722547 0.064150626705027 0.0241935483870967 0.00892920044352334 0.0519126613588635 0.63993261101408 0.23112829450739 1.42599248106691 0.391712798705636 123 1319 False False 0.598504466774877 0.237113846459026 1.25926422570726 0.00891530460624071 0.00327858628150459 0.0193032405210369 0.982767214982553 0.980476390832012 0.984854733521529 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 14 0 14 0 17 214 4717 0 0 0.0170900343744659 0.996408956485002 0.994256597661709 0.997906735895158 0 0 0.195064322969093 0 0 0.231635761650116 0 0 0.195064322969093 0 0 6.69677607158366 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 5.38399812190603 0 0 0.0170900343744659 0.996408956485002 0.994256597661709 0.997906735895158 NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations New Uncertain yes D 0 +Clofazimine mmpL5 p.Ala136_Ala139del mmpL5_p.Ala136_Ala139del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.Ala147Thr mmpL5_p.Ala147Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 14 0 14 0 16 674 14027 0 0 0.00545816471080279 0.998860642312896 0.998150412174592 0.999348622824847 0 0 0.205907214207822 0 0 0.231635761650116 0 0 0.205907214207822 0 0 6.29007724370068 1 619 1319 False False 0 0 5.41012600327403 0 0 0.00545816471080279 0.998860642312896 0.998150412174592 0.999348622824847 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 214 4731 0 0 0.0170900343744659 0.999366286438529 0.998149147855346 0.999869293957204 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 53.7295049630073 1 83 572 False False 0 0 0 0 0 0 0 0 0 53.7295049630073 0 0 0.0170900343744659 0.999366286438529 0.998149147855346 0.999869293957204 65 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Ala168Ser mmpL5_p.Ala168Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Ala199Thr mmpL5_p.Ala199Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.Ala209Thr mmpL5_p.Ala209Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1068 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Ala20Thr mmpL5_p.Ala20Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1064 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 463 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Ala230Thr mmpL5_p.Ala230Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 0 8 674 14035 0 0 0.00545816471080279 0.999430321156448 0.998877815823723 0.99975402204924 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 12.2229935310233 1 1043.5 1319 False False 0 0 12.2229935310233 0 0 0.00545816471080279 0.999430321156448 0.998877815823723 0.99975402204924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 7 214 4727 0 0 0.0170900343744659 0.998521335023236 0.996955773035796 0.999405299839924 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 15.4206152522212 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 15.4206152522212 0 0 0.0170900343744659 0.998521335023236 0.996955773035796 0.999405299839924 6 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Ala230Val mmpL5_p.Ala230Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 2 1 2 1 672 14042 0.0029673590504451 0.000359563182310977 0.0106776554748576 0.999928790144556 0.999603308654684 0.999998197124178 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 41.7916666666666 2.17098038345829 2418.88338333889 0.00609199504253242 23 1319 False False 41.7916666666666 2.17098038345829 2418.88338333889 0.0029673590504451 0.000359563182310977 0.0106776554748576 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 14 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.Ala273Gly mmpL5_p.Ala273Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 673 14042 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999928790144556 0.999603308654684 0.999998197124178 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 20.8647845468053 0.265412371331172 1613.44310281692 0.0895003241642821 90 1319 False False 20.8647845468053 0.265412371331172 1613.44310281692 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Ala273Thr mmpL5_p.Ala273Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Ala288Pro mmpL5_p.Ala288Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Ala350del mmpL5_p.Ala350del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 11 0 11 0 13 674 14030 0 0 0.00545816471080279 0.999074271879228 0.998417496974718 0.999506999611345 0 0 0.24705263800047 0 0 0.284914152918154 0 0 0.24705263800047 0 0 8.31475248610209 1 619 1319 False False 0 0 6.84763051410409 0 0 0.00545816471080279 0.999074271879228 0.998417496974718 0.999506999611345 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 0 11 0 13 214 4721 0 0 0.0170900343744659 0.997253907900295 0.995308676874106 0.998537036545967 0 0 0.24705263800047 0 0 0.284914152918154 0 0 0.24705263800047 0 0 8.85517434145136 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 7.29113432294717 0 0 0.0170900343744659 0.997253907900295 0.995308676874106 0.998537036545967 5 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Ala359Thr mmpL5_p.Ala359Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 1 3 1 3 673 14040 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999786370433668 0.999375811939756 0.999955942280632 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 6.95393759286775 0.132268015542041 86.681794653799 0.171001156837107 107 1319 False False 6.95393759286775 0.132268015542041 86.681794653799 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Ala385Thr mmpL5_p.Ala385Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Ala397Ser mmpL5_p.Ala397Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Ala401Val mmpL5_p.Ala401Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Ala434Thr mmpL5_p.Ala434Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Ala44Gly mmpL5_p.Ala44Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 672 14043 0.0029673590504451 0.000359563182310977 0.0106776554748576 1 0.999737349925893 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 3.91661217545325 Inf 0.00209443020141736 16.5 1319 False False Inf 3.91661217545325 Inf 0.0029673590504451 0.000359563182310977 0.0106776554748576 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.Ala572Val mmpL5_p.Ala572Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 674 14039 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1074 1319 False False 0 0 31.5916386345298 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Ala667Ser mmpL5_p.Ala667Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1062 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Ala668fs mmpL5_p.Ala668fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations No change no D 1 +Clofazimine mmpL5 p.Ala679Asp mmpL5_p.Ala679Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.Ala69Val mmpL5_p.Ala69Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Ala715Val mmpL5_p.Ala715Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Ala800Ser mmpL5_p.Ala800Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.Ala801Val mmpL5_p.Ala801Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1065 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.Ala896Thr mmpL5_p.Ala896Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Ala8fs mmpL5_p.Ala8fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations New Uncertain no D 0 +Clofazimine mmpL5 p.Ala956fs mmpL5_p.Ala956fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations No change no D 1 +Clofazimine mmpL5 p.Arg115fs mmpL5_p.Arg115fs 1 frameshift (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 50.4845768710802 1 619 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations New Uncertain no D 0 +Clofazimine mmpL5 p.Arg202fs mmpL5_p.Arg202fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 19 674 14024 0 0 0.00545816471080279 0.998647012746564 0.997887945605923 0.999185222909761 0 0 0.176466911806965 NA NA NA 0 0 0.176466911806965 NA NA NA NA 1059 1319 False False 0 0 4.46995253778459 0 0 0.00545816471080279 0.998647012746564 0.997887945605923 0.999185222909761 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 461 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 64 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations No change no D 1 +Clofazimine mmpL5 p.Arg244Leu mmpL5_p.Arg244Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1088 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Arg254Gln mmpL5_p.Arg254Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.Arg284fs mmpL5_p.Arg284fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations No change no D 1 +Clofazimine mmpL5 p.Arg289His mmpL5_p.Arg289His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Arg328Gly mmpL5_p.Arg328Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 1 2 673 14041 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999857580289112 0.999485626730555 0.999982751846902 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 10.4316493313521 0.176556008630772 200.333455094347 0.131204488725157 100 1319 False False 10.4316493313521 0.176556008630772 200.333455094347 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 1 2 213 4732 0.00467289719626168 0.000118300515887328 0.0257593138532706 0.999577524292353 0.998474714407054 0.999948832136202 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 11.1079812206572 0.187407717913085 213.598932938617 0.124242670676105 52.5 572 False False 0 0 0 0 0 0 0 11.1079812206572 0.187407717913085 213.598932938617 0.00467289719626168 0.000118300515887328 0.0257593138532706 0.999577524292353 0.998474714407054 0.999948832136202 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.Arg377Gln mmpL5_p.Arg377Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Arg380His mmpL5_p.Arg380His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Arg944Gln mmpL5_p.Arg944Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.Asn458Asp mmpL5_p.Asn458Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Asn466Ser mmpL5_p.Asn466Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Asn685Asp mmpL5_p.Asn685Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1060 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.Asn772Ser mmpL5_p.Asn772Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 50.4845768710802 1 619 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Asp110Gly mmpL5_p.Asp110Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.Asp128Ala mmpL5_p.Asp128Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Asp128Asn mmpL5_p.Asp128Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 5 674 14038 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 0 0 0.521823750104981 0 0 0.841886116991581 0 0 0.521823750104981 0 0 111.076905027906 1 169 1319 False False 0 0 22.7684048554448 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 465 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 42 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Asp128His mmpL5_p.Asp128His 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1066 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Asp132fs mmpL5_p.Asp132fs 1 frameshift (see "Genomic_coordinates" sheet) 1 13 0 13 0 14 674 14029 0 0 0.00545816471080279 0.999003062023784 0.998327872643959 0.99945486094574 0 0 0.231635761650116 0 0 0.24705263800047 0 0 0.231635761650116 0 0 6.84714216170221 1 169 1319 False False 0 0 6.29097464007981 0 0 0.00545816471080279 0.999003062023784 0.998327872643959 0.99945486094574 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 0 9 214 4725 0 0 0.0170900343744659 0.998098859315589 0.996394124094466 0.999130320470377 0 0 0.336267116879942 0 0 0.369416647552819 0 0 0.336267116879942 0 0 13.018420577516 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 11.2606469033018 0 0 0.0170900343744659 0.998098859315589 0.996394124094466 0.999130320470377 59 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations No change no D 1 +Clofazimine mmpL5 p.Asp143Gly mmpL5_p.Asp143Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.Asp424Asn mmpL5_p.Asp424Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 111.092568149139 1 169 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 10 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Asp455Gly mmpL5_p.Asp455Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Asp608Asn mmpL5_p.Asp608Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 14 0 14 0 18 674 14025 0 0 0.00545816471080279 0.998718222602008 0.997974992709242 0.999240166128232 0 0 0.185301968137852 0 0 0.231635761650116 0 0 0.185301968137852 0 0 6.28917984761967 1 619 1319 False False 0 0 4.74493670386334 0 0 0.00545816471080279 0.998718222602008 0.997974992709242 0.999240166128232 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 48 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Asp608Tyr mmpL5_p.Asp608Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Asp616Asn mmpL5_p.Asp616Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1080 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 469 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Asp681Glu mmpL5_p.Asp681Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.Asp767Ala mmpL5_p.Asp767Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 28 0 28 0 34 674 14009 0 0 0.00545816471080279 0.997578864914904 0.996618334442602 0.998322728693492 0 0 0.102817924259012 0 0 0.123436118500263 0 0 0.102817924259012 0 0 2.9346004665575 0.638138639971976 137 1319 False False 0 0 2.38843088756154 0 0 0.00545816471080279 0.997578864914904 0.996618334442602 0.998322728693492 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 28 0 28 0 34 214 4700 0 0 0.0170900343744659 0.992817912970004 0.98997808665339 0.995021216873519 0 0 0.102817924259012 0 0 0.123436118500263 0 0 0.102817924259012 0 0 3.11843153015048 0.632239861585363 60 572 False False 0 0 0 0 0 0 0 0 0 2.53845289233184 0 0 0.0170900343744659 0.992817912970004 0.98997808665339 0.995021216873519 25 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Asp767Asn mmpL5_p.Asp767Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 149 4263 525 9780 0.22106824925816 0.190276588604656 0.254324441738726 0.696432386242255 0.688751890838303 0.704031417449238 0.0337715321849501 0.0286385667400339 0.0395330336739416 NA NA NA 0 0 0.00086495047502073 NA NA NA NA NA NA False True 0.651104185516571 0.537180901509819 0.785411978710753 0 0 0.00700180936201277 0.696432386242255 0.688751890838303 0.704031417449238 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 49 1559 165 3175 0.228971962616822 0.174455278707026 0.291160714924445 0.670680185889311 0.657084868863477 0.684064687800327 0.0304726368159203 0.0226270511507761 0.0400879499709595 NA NA NA 0 0 0.00236338589621314 NA NA NA NA NA NA False True 1 1 1 0 0 1 0 0.604797169903007 0.42790808285796 0.84194827929371 0 0 0.022108782981671 0.670680185889311 0.657084868863477 0.684064687800327 9511 Not assoc w R 5) Not assoc w R No change yes 1 +Clofazimine mmpL5 p.Gln140His mmpL5_p.Gln140His 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Gln333Glu mmpL5_p.Gln333Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 674 14039 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 31.5916386345298 1 619 1319 False False 0 0 31.5916386345298 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 10 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Gln333Pro mmpL5_p.Gln333Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Gln504* mmpL5_p.Gln504* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations New Uncertain no D 0 +Clofazimine mmpL5 p.Gln544* mmpL5_p.Gln544* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations New Uncertain no D 0 +Clofazimine mmpL5 p.Gln60* mmpL5_p.Gln60* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations No change no D 1 +Clofazimine mmpL5 p.Gln659* mmpL5_p.Gln659* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations No change no D 1 +Clofazimine mmpL5 p.Gln702* mmpL5_p.Gln702* 1 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1079 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations No change no D 1 +Clofazimine mmpL5 p.Gln707Lys mmpL5_p.Gln707Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 11 674 14032 0 0 0.00545816471080279 0.999216691590116 0.998598878125098 0.999608912470572 0 0 0.284914152918154 0 0 0.409616397225003 0 0 0.284914152918154 0 0 14.4723097281546 1 619 1319 False False 0 0 8.31593780715244 0 0 0.00545816471080279 0.999216691590116 0.998598878125098 0.999608912470572 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 11 214 4723 0 0 0.0170900343744659 0.997676383607942 0.995846220600476 0.998839506172504 0 0 0.284914152918154 0 0 0.409616397225003 0 0 0.284914152918154 0 0 15.4075692423579 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 8.85892377666813 0 0 0.0170900343744659 0.997676383607942 0.995846220600476 0.998839506172504 11 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Glu159Ala mmpL5_p.Glu159Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.Glu174Gln mmpL5_p.Glu174Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Glu512Ala mmpL5_p.Glu512Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Glu512Gln mmpL5_p.Glu512Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 674 14037 0 0 0.00545816471080279 0.999572740867336 0.999070270474308 0.999843187804675 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 17.7219093583043 1 169 1319 False False 0 0 17.7219093583043 0 0 0.00545816471080279 0.999572740867336 0.999070270474308 0.999843187804675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Glu524Gly mmpL5_p.Glu524Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Glu552Gly mmpL5_p.Glu552Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 17 0 17 0 19 674 14024 0 0 0.00545816471080279 0.998647012746564 0.997887945605923 0.999185222909761 0 0 0.176466911806965 0 0 0.195064322969093 0 0 0.176466911806965 0 0 5.05510583032712 1 169 1319 False False 0 0 4.46995253778459 0 0 0.00545816471080279 0.998647012746564 0.997887945605923 0.999185222909761 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 15 0 15 0 17 214 4717 0 0 0.0170900343744659 0.996408956485002 0.994256597661709 0.997906735895158 0 0 0.195064322969093 0 0 0.218019360910534 0 0 0.195064322969093 0 0 6.19368404542054 1 83 572 False False 0 0 0 0 0 0 0 0 0 5.38399812190603 0 0 0.0170900343744659 0.996408956485002 0.994256597661709 0.997906735895158 34 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Glu566Asp mmpL5_p.Glu566Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Glu723Asp mmpL5_p.Glu723Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 1 4 1 4 673 14039 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999715160578224 0.999270860010958 0.999922385565456 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 5.21508172362555 0.105739966047978 52.7265413991935 0.208977451290434 113.5 1319 False False 5.21508172362555 0.105739966047978 52.7265413991935 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999715160578224 0.999270860010958 0.999922385565456 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Glu744Gln mmpL5_p.Glu744Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.Glu830Asp mmpL5_p.Glu830Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.Glu83Lys mmpL5_p.Glu83Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Glu84Ala mmpL5_p.Glu84Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Gly102Asp mmpL5_p.Gly102Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1075 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Gly114Arg mmpL5_p.Gly114Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.Gly131Arg mmpL5_p.Gly131Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 14 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.Gly181Asp mmpL5_p.Gly181Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Gly246Ser mmpL5_p.Gly246Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 43 1 42 1 45 673 13998 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.99679555650502 0.995714526028995 0.99766172577086 0.0217391304347826 0.00055023569488071 0.11527182559799 0.0232558139534883 0.000588612931593182 0.122890482701339 0.0217391304347826 0.00055023569488071 0.11527182559799 0.495223943960942 0.0122348532382603 2.92384230368206 0.722488484052481 140 1319 False False 0.462209014363546 0.0114369220836907 2.71904252081272 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.99679555650502 0.995714526028995 0.99766172577086 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 851.098742087123 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 66 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Gly257Arg mmpL5_p.Gly257Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Gly292Asp mmpL5_p.Gly292Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Gly305Ser mmpL5_p.Gly305Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 2 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.Gly336Ser mmpL5_p.Gly336Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1067 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 464 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Gly391Ser mmpL5_p.Gly391Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 19 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Gly396Cys mmpL5_p.Gly396Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Gly477Arg mmpL5_p.Gly477Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 674 14039 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 31.5916386345298 1 619 1319 False False 0 0 31.5916386345298 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 12 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Gly559Ala mmpL5_p.Gly559Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Gly609Arg mmpL5_p.Gly609Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 674 14039 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 111.084736596165 1 619 1319 False False 0 0 31.5916386345298 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 457 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Gly661Arg mmpL5_p.Gly661Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.Gly704Cys mmpL5_p.Gly704Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 50.4845768710802 1 619 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Gly748Asp mmpL5_p.Gly748Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Gly759Ser mmpL5_p.Gly759Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Gly79Ser mmpL5_p.Gly79Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1056 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 459 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Gly865Arg mmpL5_p.Gly865Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.Gly875Arg mmpL5_p.Gly875Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1085 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Gly876Asp mmpL5_p.Gly876Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.His122Arg mmpL5_p.His122Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 24 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.His437Arg mmpL5_p.His437Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 0 8 674 14035 0 0 0.00545816471080279 0.999430321156448 0.998877815823723 0.99975402204924 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 12.2229935310233 1 1043.5 1319 False False 0 0 12.2229935310233 0 0 0.00545816471080279 0.999430321156448 0.998877815823723 0.99975402204924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.His454Gln mmpL5_p.His454Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.His494Tyr mmpL5_p.His494Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.His540Arg mmpL5_p.His540Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.His590Arg mmpL5_p.His590Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.His590Pro mmpL5_p.His590Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 50.4845768710802 1 619 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.His656Tyr mmpL5_p.His656Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1092 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 476 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.His77Asn mmpL5_p.His77Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.His825fs mmpL5_p.His825fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations No change no D 1 +Clofazimine mmpL5 p.Ile113Thr mmpL5_p.Ile113Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Ile215Val mmpL5_p.Ile215Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 50.4845768710802 1 619 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Ile282Leu mmpL5_p.Ile282Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Ile36Met mmpL5_p.Ile36Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1069 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 466 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Ile484Thr mmpL5_p.Ile484Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1054 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Ile529Met mmpL5_p.Ile529Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Ile555_Gly559del mmpL5_p.Ile555_Gly559del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.Ile59Thr mmpL5_p.Ile59Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 7 674 14036 0 0 0.00545816471080279 0.999501531011892 0.998973234784508 0.999799566877855 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 17.720647938943 1 619 1319 False False 0 0 14.476435679416 0 0 0.00545816471080279 0.999501531011892 0.998973234784508 0.999799566877855 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Ile732Val mmpL5_p.Ile732Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 111.092568149139 1 169 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 2 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Ile735fs mmpL5_p.Ile735fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1096 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations New Uncertain no D 0 +Clofazimine mmpL5 p.Ile787Met mmpL5_p.Ile787Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Ile829Val mmpL5_p.Ile829Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 2 673 14041 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999857580289112 0.999485626730555 0.999982751846902 0.333333333333333 0.00840375865961264 0.905700675949754 0.5 0.012579117093425 0.987420882906574 0.333333333333333 0.00840375865961264 0.905700675949754 20.8632986627043 0.265393470016011 1613.33005200251 0.0895062636593418 94 1319 False False 10.4316493313521 0.176556008630772 200.333455094347 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 468 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Ile841Val mmpL5_p.Ile841Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 3 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Ile910fs mmpL5_p.Ile910fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1063 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations New Uncertain no D 0 +Clofazimine mmpL5 p.Ile910Val mmpL5_p.Ile910Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Ile948Ala mmpL5_p.Ile948Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1070 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Ile948Val mmpL5_p.Ile948Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 50 1 49 662 13989 12 54 0.982195845697329 0.969106420824509 0.990767347012732 0.00384533219397564 0.00289001237273849 0.00501438268957782 0.0451846290355607 0.0418777847440302 0.0486735591835728 0.02 0.000506227983040829 0.106469545711499 7.14796283059328e-05 1.80970586671838e-06 0.000398193933319449 0.0918367346938775 0.00211097267163254 0.672806124576086 0.00645321165358493 NA NA False True 0.212953034527128 0.111840248553764 0.439638356358107 0.0769230769230769 0.00194562849734675 0.360297435267877 0.00384533219397564 0.00289001237273849 0.00501438268957782 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 2 0 2 209 4719 5 15 0.976635514018691 0.946320269321486 0.992371077905216 0.00316856780735107 0.00177447441739132 0.00522069412660923 0.0424107142857142 0.036955388146125 0.0484161089541689 0 0 0.841886116991581 0 0 0.000781402419299906 0 0 19.1734178939493 1 NA NA False True 1 1 1 0 0 1 0 0.132867132867132 0.0454027315426947 0.47228106247539 0 0 0.521823750104981 0.00316856780735107 0.00177447441739132 0.00522069412660923 37262 Not assoc w R 5) Not assoc w R No change yes 1 +Clofazimine mmpL5 p.Leu219Phe mmpL5_p.Leu219Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 673 14040 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999786370433668 0.999375811939756 0.999955942280632 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 50.5599546514372 1 619 1319 False False 6.95393759286775 0.132268015542041 86.681794653799 0 0 0.00546625270429624 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 16 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Leu329Arg mmpL5_p.Leu329Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Leu335Val mmpL5_p.Leu335Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.Leu523Pro mmpL5_p.Leu523Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Leu630fs mmpL5_p.Leu630fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1057 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations New Uncertain no D 0 +Clofazimine mmpL5 p.Leu653Met mmpL5_p.Leu653Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1052 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.Leu691Arg mmpL5_p.Leu691Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.Leu709Ile mmpL5_p.Leu709Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1072 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.Leu751Phe mmpL5_p.Leu751Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.534232413570953 Inf 0.0457973771828497 55 1319 False False Inf 0.534232413570953 Inf 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.Leu810Phe mmpL5_p.Leu810Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 2 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Leu818Met mmpL5_p.Leu818Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.Leu836Phe mmpL5_p.Leu836Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 17 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Leu95Arg mmpL5_p.Leu95Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 118.033875066473 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Leu95Pro mmpL5_p.Leu95Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Lys467Arg mmpL5_p.Lys467Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1077 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 10 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Lys467fs mmpL5_p.Lys467fs 1 frameshift (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 674 14039 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 31.5916386345298 1 619 1319 False False 0 0 31.5916386345298 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 12 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations No change no D 1 +Clofazimine mmpL5 p.Lys589fs mmpL5_p.Lys589fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1048 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations No change no D 1 +Clofazimine mmpL5 p.Lys646Gln mmpL5_p.Lys646Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Lys649Thr mmpL5_p.Lys649Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Lys80Gln mmpL5_p.Lys80Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Lys935Asn mmpL5_p.Lys935Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Met218Val mmpL5_p.Met218Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.534232413570953 Inf 0.0457973771828497 55 1319 False False Inf 0.534232413570953 Inf 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.Met443Thr mmpL5_p.Met443Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Met503Arg mmpL5_p.Met503Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Met503Ile mmpL5_p.Met503Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Met560Leu mmpL5_p.Met560Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Met560Thr mmpL5_p.Met560Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1081 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 21 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Met638_Met641del mmpL5_p.Met638_Met641del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Met638Leu mmpL5_p.Met638Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 118.033875066473 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Met645Ile mmpL5_p.Met645Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Met655Ile mmpL5_p.Met655Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Met655Thr mmpL5_p.Met655Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 35 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Met666Ile mmpL5_p.Met666Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 118.033875066473 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 3 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Met676Val mmpL5_p.Met676Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1083 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Met72Thr mmpL5_p.Met72Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1086 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.Met892Ile mmpL5_p.Met892Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 118.033875066473 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 3 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Met892Thr mmpL5_p.Met892Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.Met892Val mmpL5_p.Met892Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 2 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Met903Ile mmpL5_p.Met903Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1095 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Phe108Leu mmpL5_p.Phe108Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Phe129Ser mmpL5_p.Phe129Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Phe574Leu mmpL5_p.Phe574Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1097 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 477 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Phe696Leu mmpL5_p.Phe696Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 254 670 13789 0.0059347181008902 0.00161930788766713 0.0151250012595154 0.981912696717225 0.979570383415574 0.984052164645481 0.0155038759689922 0.00424002258879533 0.0392181109900084 NA NA NA 0 0 0.0144181952442443 NA NA NA NA NA NA False True 0.324103889998824 0.0873906838239337 0.8441469024181 0 0 0.00549066114558213 0.981912696717225 0.979570383415574 0.984052164645481 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 4 227 210 4507 0.0186915887850467 0.00511573452207981 0.0471638210086244 0.952049007182087 0.945572258593315 0.957960572528279 0.0173160173160173 0.00473767899260049 0.0437399684365042 NA NA NA 0 0 0.0161192421133921 NA NA NA NA NA NA False True 1 1 1 0 0 1 0 0.37818334382211 0.101186061741148 0.996803701787839 0 0 0.0174127082678636 0.952049007182087 0.945572258593315 0.957960572528279 502 Not assoc w R 5) Not assoc w R No change yes 1 +Clofazimine mmpL5 p.Phe816Leu mmpL5_p.Phe816Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Phe82fs mmpL5_p.Phe82fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations No change no D 1 +Clofazimine mmpL5 p.Phe82Leu mmpL5_p.Phe82Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 50.4845768710802 1 619 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 214 4731 0 0 0.0170900343744659 0.999366286438529 0.998149147855346 0.999869293957204 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 53.7295049630073 1 83 572 False False 0 0 0 0 0 0 0 0 0 53.7295049630073 0 0 0.0170900343744659 0.999366286438529 0.998149147855346 0.999869293957204 2 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Phe890Ser mmpL5_p.Phe890Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1084 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 471 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.Phe916Ser mmpL5_p.Phe916Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Pro179Thr mmpL5_p.Pro179Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Pro180Leu mmpL5_p.Pro180Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 50.4845768710802 1 619 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Pro338Ala mmpL5_p.Pro338Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1082 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 470 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Pro390fs mmpL5_p.Pro390fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations No change no D 1 +Clofazimine mmpL5 p.Pro390Ser mmpL5_p.Pro390Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1094 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.Pro390Thr mmpL5_p.Pro390Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 118.033875066473 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 2 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Pro445Leu mmpL5_p.Pro445Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 1 673 14042 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999928790144556 0.999603308654684 0.999998197124178 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.534194369017788 Inf 0.0458004892633867 82.5 1319 False False 20.8647845468053 0.265412371331172 1613.44310281692 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Pro498fs mmpL5_p.Pro498fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1078 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 25 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations New Uncertain no D 0 +Clofazimine mmpL5 p.Pro927Arg mmpL5_p.Pro927Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Pro947Ser mmpL5_p.Pro947Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Pro953Ser mmpL5_p.Pro953Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1049 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Ser125Cys mmpL5_p.Ser125Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 674 14038 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 22.7684048554448 1 169 1319 False False 0 0 22.7684048554448 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 214 4730 0 0 0.0170900343744659 0.999155048584706 0.997838014616212 0.999769732715123 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 33.6387430781262 1 83 572 False False 0 0 0 0 0 0 0 0 0 33.6387430781262 0 0 0.0170900343744659 0.999155048584706 0.997838014616212 0.999769732715123 46 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Ser439Ala mmpL5_p.Ser439Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.Ser439Pro mmpL5_p.Ser439Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 50.4845768710802 1 619 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 214 4731 0 0 0.0170900343744659 0.999366286438529 0.998149147855346 0.999869293957204 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 53.7295049630073 1 83 572 False False 0 0 0 0 0 0 0 0 0 53.7295049630073 0 0 0.0170900343744659 0.999366286438529 0.998149147855346 0.999869293957204 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.Ser452Asn mmpL5_p.Ser452Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1073 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.Ser479fs mmpL5_p.Ser479fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations No change no D 1 +Clofazimine mmpL5 p.Ser507Asn mmpL5_p.Ser507Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 8 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.Ser541Arg mmpL5_p.Ser541Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 118.033875066473 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Ser583Asn mmpL5_p.Ser583Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Ser599Leu mmpL5_p.Ser599Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 118.033875066473 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 5 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.Ser654Thr mmpL5_p.Ser654Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Ser65Arg mmpL5_p.Ser65Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Ser71Pro mmpL5_p.Ser71Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 674 14039 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 31.5916386345298 1 619 1319 False False 0 0 31.5916386345298 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Ser728fs mmpL5_p.Ser728fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 802.34555512305 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations New Uncertain no D 0 +Clofazimine mmpL5 p.Ser782Ala mmpL5_p.Ser782Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1053 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Ser879Leu mmpL5_p.Ser879Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Ser894* mmpL5_p.Ser894* 1 stop_gained (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 674 14038 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 22.7684048554448 1 169 1319 False False 0 0 22.7684048554448 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations No change no D 1 +Clofazimine mmpL5 p.Thr10Ala mmpL5_p.Thr10Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Thr120Ala mmpL5_p.Thr120Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1071 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 467 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Thr234Met mmpL5_p.Thr234Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.Thr327Ile mmpL5_p.Thr327Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.Thr334fs mmpL5_p.Thr334fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations No change no D 1 +Clofazimine mmpL5 p.Thr352Ile mmpL5_p.Thr352Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Thr519Ala mmpL5_p.Thr519Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.Thr606Ala mmpL5_p.Thr606Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Thr6Ala mmpL5_p.Thr6Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.Thr794Ile mmpL5_p.Thr794Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 479 8100 195 5943 0.710682492581602 0.674836859386984 0.74467129284808 0.423200170903653 0.415009652272336 0.431422526291869 0.055834013288262 0.0510687414194798 0.0609036704271563 NA NA NA 0 0 0.000455313529877537 NA NA NA NA NA NA False True 1.80227730294396 1.51728467905845 2.1471095880188 0 0 0.0187395208302859 0.423200170903653 0.415009652272336 0.431422526291869 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 179 3782 35 952 0.836448598130841 0.779951314691771 0.883358596722478 0.201098436839881 0.189761985468608 0.212804728987264 0.045190608432214 0.0389332191338073 0.0521294243692205 NA NA NA 0 0 0.000974902436017582 NA NA NA NA NA NA False True 1 1 1 0 0 1 0 1.28736118455843 0.885104823428724 1.9197022160873 0 0 0.100032435572105 0.201098436839881 0.189761985468608 0.212804728987264 19169 Not assoc w R 5) Not assoc w R No change yes 1 +Clofazimine mmpL5 p.Thr918fs mmpL5_p.Thr918fs 1 frameshift (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 674 14038 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 22.7684048554448 1 169 1319 False False 0 0 22.7684048554448 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations No change no D 1 +Clofazimine mmpL5 p.Trp130fs mmpL5_p.Trp130fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations No change no D 1 +Clofazimine mmpL5 p.Trp598Arg mmpL5_p.Trp598Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 30 0 30 0 30 674 14013 0 0 0.00545816471080279 0.99786370433668 0.996951698182168 0.998558200432382 0 0 0.115703308222027 0 0 0.115703308222027 0 0 0.115703308222027 0 0 2.72759994828658 0.401146915463571 125 1319 False False 0 0 2.72759994828658 0 0 0.00545816471080279 0.99786370433668 0.996951698182168 0.998558200432382 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 34 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Trp598Cys mmpL5_p.Trp598Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1076 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.Trp598Gly mmpL5_p.Trp598Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Trp823Arg mmpL5_p.Trp823Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1047 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 455 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Trp833* mmpL5_p.Trp833* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations No change no D 1 +Clofazimine mmpL5 p.Trp936Arg mmpL5_p.Trp936Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 674 14039 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 31.5916386345298 1 619 1319 False False 0 0 31.5916386345298 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 11 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Trp938Arg mmpL5_p.Trp938Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Trp952Leu mmpL5_p.Trp952Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 26 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Tyr185* mmpL5_p.Tyr185* 1 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1093 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations No change no D 1 +Clofazimine mmpL5 p.Tyr299Cys mmpL5_p.Tyr299Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Tyr300* mmpL5_p.Tyr300* 1 stop_gained (see "Genomic_coordinates" sheet) 1 145 6 139 7 157 667 13886 0.0103857566765578 0.00418552311154975 0.0212809513555928 0.988820052695293 0.98694044006591 0.990492783053673 0.0426829268292682 0.0173304100123535 0.0859634751841975 0.0413793103448275 0.0153345582420563 0.0878876902424837 0.0368098159509202 0.0136262983417448 0.0783949452262962 0.898644203078316 0.323036468122247 2.01665766339879 1 619 1319 False False 0.928217419952444 0.365692216477793 1.96887708108256 0.00891530460624071 0.00327858628150459 0.0193032405210369 0.988820052695293 0.98694044006591 0.990492783053673 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 373 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations No change no D 1 +Clofazimine mmpL5 p.Tyr411Asp mmpL5_p.Tyr411Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Tyr415Cys mmpL5_p.Tyr415Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1087 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 472 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Tyr514Cys mmpL5_p.Tyr514Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Tyr586* mmpL5_p.Tyr586* 1 stop_gained (see "Genomic_coordinates" sheet) 1 7 0 7 0 7 674 14036 0 0 0.00545816471080279 0.999501531011892 0.998973234784508 0.999799566877855 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 14.476435679416 1 169 1319 False False 0 0 14.476435679416 0 0 0.00545816471080279 0.999501531011892 0.998973234784508 0.999799566877855 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations No change no D 1 +Clofazimine mmpL5 p.Val123Ile mmpL5_p.Val123Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Val149Ile mmpL5_p.Val149Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1058 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 460 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 2 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Val151Gly mmpL5_p.Val151Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1050 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 456 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Val182Ile mmpL5_p.Val182Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.Val186Ile mmpL5_p.Val186Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Val186Leu mmpL5_p.Val186Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1061 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 462 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Val214Leu mmpL5_p.Val214Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 674 14038 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 22.7684048554448 1 169 1319 False False 0 0 22.7684048554448 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Val222Gly mmpL5_p.Val222Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Val247Ala mmpL5_p.Val247Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 31 673 14012 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.997792494481236 0.99686807299094 0.998499629457529 0.03125 0.000790868597952557 0.162170994181511 NA NA NA 0 0 0.11218874692237 NA NA NA NA 1089 1319 False False 0.671619613670133 0.0164549015930408 4.04293275185674 0 0 0.00546625270429624 0.997792494481236 0.99686807299094 0.998499629457529 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 473 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 22 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Val247fs mmpL5_p.Val247fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1090 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 474 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI Rv0678 mutations New Uncertain no D 0 +Clofazimine mmpL5 p.Val267Gly mmpL5_p.Val267Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Val268Met mmpL5_p.Val268Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Val337Met mmpL5_p.Val337Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 50.4845768710802 1 619 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Val344Leu mmpL5_p.Val344Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 29 0 29 0 31 674 14012 0 0 0.00545816471080279 0.997792494481236 0.99686807299094 0.998499629457529 0 0 0.11218874692237 0 0 0.119444869069502 0 0 0.11218874692237 0 0 2.82751891278638 0.642359877943841 138 1319 False False 0 0 2.63412099576211 0 0 0.00545816471080279 0.997792494481236 0.99686807299094 0.998499629457529 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 8 214 4726 0 0 0.0170900343744659 0.998310097169412 0.996672947522823 0.999270146456405 0 0 0.369416647552819 0 0 0.409616397225003 0 0 0.369416647552819 0 0 15.4173537499273 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 13.0211752369257 0 0 0.0170900343744659 0.998310097169412 0.996672947522823 0.999270146456405 234 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Val346Ala mmpL5_p.Val346Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1091 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 475 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 4 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Val360Met mmpL5_p.Val360Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.Val376Ala mmpL5_p.Val376Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1055 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 458 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 2 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.Val382Ala mmpL5_p.Val382Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.Val41Ile mmpL5_p.Val41Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1051 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.Val481Met mmpL5_p.Val481Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Val48Ile mmpL5_p.Val48Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Val612Gly mmpL5_p.Val612Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1098 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Val612Ile mmpL5_p.Val612Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.Val695Ile mmpL5_p.Val695Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.Val820Leu mmpL5_p.Val820Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.Val840Ile mmpL5_p.Val840Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 5 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpL5 p.Val846Ile mmpL5_p.Val846Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Val942Ile mmpL5_p.Val942Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Clofazimine mmpL5 p.Val964Leu mmpL5_p.Val964Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Clofazimine mmpS5 c.126G>A mmpS5_c.126G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 674 14038 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 22.7684048554448 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 5 214 4729 0 0 0.0170900343744659 0.998943810730883 0.997536942130593 0.999656972101492 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 24.2508634033673 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpS5 c.-14A>C mmpS5_c.-14A>C 1 upstream_gene_variant 778919 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Clofazimine mmpS5 c.168G>C mmpS5_c.168G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpS5 c.174C>T mmpS5_c.174C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpS5 c.189C>T mmpS5_c.189C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpS5 c.-19G>A mmpS5_c.-19G>A 1 upstream_gene_variant 778924 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Clofazimine mmpS5 c.204C>T mmpS5_c.204C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpS5 c.-20T>C mmpS5_c.-20T>C 1 upstream_gene_variant 778925 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpS5 c.216G>A mmpS5_c.216G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpS5 c.-22C>T mmpS5_c.-22C>T 1 upstream_gene_variant 778927 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine mmpS5 c.261G>C mmpS5_c.261G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpS5 c.273C>G mmpS5_c.273C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpS5 c.282C>T mmpS5_c.282C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 11 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpS5 c.306C>T mmpS5_c.306C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpS5 c.315G>C mmpS5_c.315G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.534232413570953 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpS5 c.-31C>G mmpS5_c.-31C>G 1 upstream_gene_variant 778936 1 0 0 0 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1189 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpS5 c.333C>A mmpS5_c.333C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpS5 c.34C>T mmpS5_c.34C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpS5 c.-34C>T mmpS5_c.-34C>T 1 upstream_gene_variant 778939 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpS5 c.-35C>T mmpS5_c.-35C>T 1 upstream_gene_variant 778940 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine mmpS5 c.-36A>G mmpS5_c.-36A>G 1 upstream_gene_variant 778941 1 9 0 9 0 20 674 14023 0 0 0.00545816471080279 0.99857580289112 0.997801295863414 0.999129853182603 0 0 0.168433470983085 0 0 0.336267116879942 0 0 0.168433470983085 0 0 10.561876487513 1 619 1319 False False 0 0 4.22500110335693 0 0 0.00545816471080279 0.99857580289112 0.997801295863414 0.999129853182603 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 0 18 214 4716 0 0 0.0170900343744659 0.996197718631178 0.993997388291213 0.997745017823554 0 0 0.185301968137852 0 0 0.369416647552819 0 0 0.185301968137852 0 0 12.9936286746663 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 5.0524201521135 0 0 0.0170900343744659 0.996197718631178 0.993997388291213 0.997745017823554 15 3) Uncertain significance No change no 1 +Clofazimine mmpS5 c.387C>T mmpS5_c.387C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpS5 c.393G>T mmpS5_c.393G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpS5 c.399C>T mmpS5_c.399C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpS5 c.39C>G mmpS5_c.39C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 118.033875066473 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpS5 c.-39C>T mmpS5_c.-39C>T 1 upstream_gene_variant 778944 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine mmpS5 c.400C>T mmpS5_c.400C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpS5 c.402G>A mmpS5_c.402G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 50.4845768710802 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpS5 c.42C>A mmpS5_c.42C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpS5 c.42C>T mmpS5_c.42C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpS5 c.-519_-82del mmpS5_c.-519_-82del 1 upstream_gene_variant 778986 0 0 0 0 1 6 673 14037 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999572740867336 0.999070270474308 0.999843187804675 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1184 1319 False False 3.47622585438335 0.0754632221460442 28.7341429523688 0 0 0.00546625270429624 0.999572740867336 0.999070270474308 0.999843187804675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 519 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpS5 c.-51G>A mmpS5_c.-51G>A 1 upstream_gene_variant 778956 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine mmpS5 c.-55G>C mmpS5_c.-55G>C 1 upstream_gene_variant 778960 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpS5 c.-56C>T mmpS5_c.-56C>T 1 upstream_gene_variant 778961 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Clofazimine mmpS5 c.-60G>A mmpS5_c.-60G>A 1 upstream_gene_variant 778965 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpS5 c.-63T>G mmpS5_c.-63T>G 1 upstream_gene_variant 778968 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpS5 c.-65_-64insGAA mmpS5_c.-65_-64insGAA 1 upstream_gene_variant 778969 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpS5 c.-65A>G mmpS5_c.-65A>G 1 upstream_gene_variant 778970 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Clofazimine mmpS5 c.66C>T mmpS5_c.66C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpS5 c.6T>C mmpS5_c.6T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpS5 c.-71C>A mmpS5_c.-71C>A 1 upstream_gene_variant 778976 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1195 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 525 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpS5 c.-71C>T mmpS5_c.-71C>T 1 upstream_gene_variant 778976 1 1 1 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.534232413570953 Inf 0.0457973771828497 55 1319 False False Inf 0.534232413570953 Inf 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpS5 c.-74G>T mmpS5_c.-74G>T 1 upstream_gene_variant 778979 1 64 1 63 5 73 669 13970 0.00741839762611276 0.00241299320385175 0.0172265646313554 0.994801680552588 0.993468269240872 0.9959231995347 0.0641025641025641 0.0211397204114613 0.143287596106885 0.015625 0.000395512514050664 0.0840103264343536 0.0135135135135135 0.000342074019664797 0.0730073885096648 0.331458941324412 0.00825315197354811 1.92176983854774 0.370621300106832 120 1319 False False 1.43026803448205 0.449456650190728 3.5096739693354 0.00149253731343283 3.77870591619749e-05 0.00828756997282798 0.994801680552588 0.993468269240872 0.9959231995347 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 214 4731 0 0 0.0170900343744659 0.999366286438529 0.998149147855346 0.999869293957204 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 53.7295049630073 1 83 572 False False 0 0 0 0 0 0 0 0 0 53.7295049630073 0 0 0.0170900343744659 0.999366286438529 0.998149147855346 0.999869293957204 329 3) Uncertain significance No change no 1 +Clofazimine mmpS5 c.-75T>C mmpS5_c.-75T>C 1 upstream_gene_variant 778980 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1180 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 517 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine mmpS5 c.-75T>G mmpS5_c.-75T>G 1 upstream_gene_variant 778980 1 1 1 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.534232413570953 Inf 0.0457973771828497 55 1319 False False Inf 0.534232413570953 Inf 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 213 4734 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.56721266938512 Inf 0.0432497978981406 34 572 False False 0 0 0 0 0 0 0 Inf 0.56721266938512 Inf 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpS5 c.-79_-78insT mmpS5_c.-79_-78insT 1 upstream_gene_variant 778983 1 1 1 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.534232413570953 Inf 0.0457973771828497 55 1319 False False Inf 0.534232413570953 Inf 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 213 4734 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.56721266938512 Inf 0.0432497978981406 34 572 False False 0 0 0 0 0 0 0 Inf 0.56721266938512 Inf 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpS5 c.81G>A mmpS5_c.81G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpS5 c.81G>C mmpS5_c.81G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpS5 c.-82G>T mmpS5_c.-82G>T 1 upstream_gene_variant 778987 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpS5 c.-83_-82insA mmpS5_c.-83_-82insA 1 upstream_gene_variant 778987 0 0 0 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1193 1319 False False Inf 0.534232413570953 Inf 0 0 0.00546625270429624 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 213 4734 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 524 572 False False 0 0 0 0 0 0 0 Inf 0.56721266938512 Inf 0 0 0.0171695765109405 1 0.999221072542716 1 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpS5 c.-84A>C mmpS5_c.-84A>C 1 upstream_gene_variant 778989 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpS5 c.-9_-8delCG mmpS5_c.-9_-8delCG 1 upstream_gene_variant 778912 1 0 0 0 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1187 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpS5 c.90T>C mmpS5_c.90T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpS5 c.9A>G mmpS5_c.9A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine mmpS5 c.-9C>T mmpS5_c.-9C>T 1 upstream_gene_variant 778914 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpS5 LoF mmpS5_LoF 1 LoF (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 111.092568149139 1 169 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 570 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpS5 p.Ala133Thr mmpS5_p.Ala133Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine mmpS5 p.Ala142Ser mmpS5_p.Ala142Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpS5 p.Ala45fs mmpS5_p.Ala45fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1191 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 523 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine mmpS5 p.Ala84Glu mmpS5_p.Ala84Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1182 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 518 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine mmpS5 p.Ala8Ser mmpS5_p.Ala8Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1181 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpS5 p.Ala8Val mmpS5_p.Ala8Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 674 14038 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 22.7684048554448 1 169 1319 False False 0 0 22.7684048554448 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 214 4730 0 0 0.0170900343744659 0.999155048584706 0.997838014616212 0.999769732715123 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 33.6387430781262 1 83 572 False False 0 0 0 0 0 0 0 0 0 33.6387430781262 0 0 0.0170900343744659 0.999155048584706 0.997838014616212 0.999769732715123 7 3) Uncertain significance No change no 1 +Clofazimine mmpS5 p.Arg29Cys mmpS5_p.Arg29Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine mmpS5 p.Arg29Leu mmpS5_p.Arg29Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpS5 p.Asp119fs mmpS5_p.Asp119fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Clofazimine mmpS5 p.Asp82Glu mmpS5_p.Asp82Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpS5 p.Cys114Ser mmpS5_p.Cys114Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpS5 p.Glu59Lys mmpS5_p.Glu59Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine mmpS5 p.Gly109Asp mmpS5_p.Gly109Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1186 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Clofazimine mmpS5 p.Gly109Ser mmpS5_p.Gly109Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1188 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 521 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 33 3) Uncertain significance No change no 1 +Clofazimine mmpS5 p.Gly130Arg mmpS5_p.Gly130Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 673 14042 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999928790144556 0.999603308654684 0.999998197124178 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 20.8647845468053 0.265412371331172 1613.44310281692 0.0895003241642821 90 1319 False False 20.8647845468053 0.265412371331172 1613.44310281692 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpS5 p.Gly130Asp mmpS5_p.Gly130Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 50.4845768710802 1 619 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 118.033875066473 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 2 3) Uncertain significance No change no 1 +Clofazimine mmpS5 p.Ile116Leu mmpS5_p.Ile116Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpS5 p.Ile14Thr mmpS5_p.Ile14Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpS5 p.Ile69Val mmpS5_p.Ile69Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance No change no 1 +Clofazimine mmpS5 p.Lys123fs mmpS5_p.Lys123fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpS5 p.Lys42Arg mmpS5_p.Lys42Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Clofazimine mmpS5 p.Lys6Thr mmpS5_p.Lys6Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpS5 p.Pro101Arg mmpS5_p.Pro101Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpS5 p.Pro53Leu mmpS5_p.Pro53Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1183 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpS5 p.Pro78Leu mmpS5_p.Pro78Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1192 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 25 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpS5 p.Ser34Phe mmpS5_p.Ser34Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Clofazimine mmpS5 p.Ser98Pro mmpS5_p.Ser98Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 5 674 14038 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1190 1319 False False 0 0 22.7684048554448 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 214 4729 0 0 0.0170900343744659 0.998943810730883 0.997536942130593 0.999656972101492 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 522 572 False False 0 0 0 0 0 0 0 0 0 24.2508634033673 0 0 0.0170900343744659 0.998943810730883 0.997536942130593 0.999656972101492 1 3) Uncertain significance No change no 1 +Clofazimine mmpS5 p.Thr113Asn mmpS5_p.Thr113Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpS5 p.Thr24Ala mmpS5_p.Thr24Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine mmpS5 p.Thr24Met mmpS5_p.Thr24Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 8 674 14035 0 0 0.00545816471080279 0.999430321156448 0.998877815823723 0.99975402204924 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1185 1319 False False 0 0 12.2229935310233 0 0 0.00545816471080279 0.999430321156448 0.998877815823723 0.99975402204924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 7 214 4727 0 0 0.0170900343744659 0.998521335023236 0.996955773035796 0.999405299839924 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 520 572 False False 0 0 0 0 0 0 0 0 0 15.4206152522212 0 0 0.0170900343744659 0.998521335023236 0.996955773035796 0.999405299839924 7 3) Uncertain significance No change no 1 +Clofazimine mmpS5 p.Thr4Ile mmpS5_p.Thr4Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Clofazimine mmpS5 p.Thr4Pro mmpS5_p.Thr4Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 674 14037 0 0 0.00545816471080279 0.999572740867336 0.999070270474308 0.999843187804675 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 17.7219093583043 1 169 1319 False False 0 0 17.7219093583043 0 0 0.00545816471080279 0.999572740867336 0.999070270474308 0.999843187804675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 214 4729 0 0 0.0170900343744659 0.998943810730883 0.997536942130593 0.999656972101492 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 24.2508634033673 1 83 572 False False 0 0 0 0 0 0 0 0 0 24.2508634033673 0 0 0.0170900343744659 0.998943810730883 0.997536942130593 0.999656972101492 NA 3) Uncertain significance No change no 1 +Clofazimine mmpS5 p.Val131_Asp132insThrGlyVal mmpS5_p.Val131_Asp132insThrGlyVal 1 inframe_insertion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine mmpS5 p.Val55Met mmpS5_p.Val55Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 22 3) Uncertain significance No change no 1 +Clofazimine mmpS5 p.Val56Met mmpS5_p.Val56Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance No change no 1 +Clofazimine mmpS5 p.Val67Gly mmpS5_p.Val67Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 50.4845768710802 1 619 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Clofazimine mmpS5 p.Val67Ile mmpS5_p.Val67Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1194 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine pepQ c.1029A>C pepQ_c.1029A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine pepQ c.105C>A pepQ_c.105C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine pepQ c.1107G>C pepQ_c.1107G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine pepQ c.132G>A pepQ_c.132G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine pepQ c.144T>C pepQ_c.144T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine pepQ c.153T>C pepQ_c.153T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine pepQ c.165C>T pepQ_c.165C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine pepQ c.183C>T pepQ_c.183C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine pepQ c.189G>A pepQ_c.189G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine pepQ c.-18C>T pepQ_c.-18C>T 1 upstream_gene_variant 2860436 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1144 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 504 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 13 3) Uncertain significance New Uncertain no 0 +Clofazimine pepQ c.198G>A pepQ_c.198G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine pepQ c.1G>A pepQ_c.1G>A 1 initiator_codon_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine pepQ c.21A>C pepQ_c.21A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 118.033875066473 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine pepQ c.-22G>A pepQ_c.-22G>A 1 upstream_gene_variant 2860440 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine pepQ c.240G>A pepQ_c.240G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 674 14039 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.5916386345298 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 214 4731 0 0 0.0170900343744659 0.999366286438529 0.998149147855346 0.999869293957204 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 53.7295049630073 NA NA NA NA NA NA 24 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine pepQ c.261C>G pepQ_c.261C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine pepQ c.318C>T pepQ_c.318C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine pepQ c.339G>A pepQ_c.339G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine pepQ c.372A>G pepQ_c.372A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 50.4845768710802 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine pepQ c.381T>C pepQ_c.381T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine pepQ c.411C>T pepQ_c.411C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine pepQ c.460C>T pepQ_c.460C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine pepQ c.483C>T pepQ_c.483C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 118.033875066473 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine pepQ c.516G>A pepQ_c.516G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine pepQ c.54G>T pepQ_c.54G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 8 674 14035 0 0 0.00545816471080279 0.999430321156448 0.998877815823723 0.99975402204924 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 12.2229935310233 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 8 214 4726 0 0 0.0170900343744659 0.998310097169412 0.996672947522823 0.999270146456405 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 13.0211752369257 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine pepQ c.552C>T pepQ_c.552C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine pepQ c.555T>G pepQ_c.555T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 6 674 14037 0 0 0.00545816471080279 0.999572740867336 0.999070270474308 0.999843187804675 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 17.7219093583043 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 14 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine pepQ c.558C>T pepQ_c.558C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine pepQ c.582G>A pepQ_c.582G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine pepQ c.585T>C pepQ_c.585T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine pepQ c.-5G>A pepQ_c.-5G>A 1 upstream_gene_variant 2860423 1 2 0 2 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 111.092568149139 1 169 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine pepQ c.693C>T pepQ_c.693C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine pepQ c.696T>C pepQ_c.696T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine pepQ c.69G>A pepQ_c.69G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine pepQ c.72C>T pepQ_c.72C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 673 14042 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999928790144556 0.999603308654684 0.999998197124178 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 20.8647845468053 0.265412371331172 1613.44310281692 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 213 4734 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.56721266938512 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine pepQ c.756G>T pepQ_c.756G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine pepQ c.768G>A pepQ_c.768G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine pepQ c.774G>A pepQ_c.774G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine pepQ c.795G>A pepQ_c.795G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 674 14039 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.5916386345298 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 11 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine pepQ c.804C>G pepQ_c.804C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 674 14039 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.5916386345298 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine pepQ c.873T>G pepQ_c.873T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 7 674 14036 0 0 0.00545816471080279 0.999501531011892 0.998973234784508 0.999799566877855 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 14.476435679416 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 214 4730 0 0 0.0170900343744659 0.999155048584706 0.997838014616212 0.999769732715123 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 33.6387430781262 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine pepQ c.876C>T pepQ_c.876C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 674 14038 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 22.7684048554448 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine pepQ c.879A>G pepQ_c.879A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine pepQ c.936C>G pepQ_c.936C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine pepQ c.93A>G pepQ_c.93A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine pepQ c.945A>C pepQ_c.945A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine pepQ c.97C>T pepQ_c.97C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine pepQ c.99A>G pepQ_c.99A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine pepQ LoF pepQ_LoF 1 LoF (see "Genomic_coordinates" sheet) 1 3 1 2 3 3 671 14040 0.00445103857566765 0.00091885344774779 0.0129522747681396 0.999786370433668 0.999375811939756 0.999955942280632 0.5 0.118117248757025 0.881882751242974 0.333333333333333 0.00840375865961264 0.905700675949754 0.25 0.00630946320970987 0.805879550316756 10.461997019374 0.177068867821406 200.914786508413 0.130858648684435 96 1319 False False 20.9239940387481 2.79529541381657 156.499833266082 0.00148809523809523 3.76745997948712e-05 0.00826298844437611 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA Marker of R BDQ-CFZ cross-resistance 2) Assoc w R - Interim New AwRI yes BDQ-CFZ X-R 5 +Clofazimine pepQ p.Ala124Val pepQ_p.Ala124Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 802.34555512305 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Clofazimine pepQ p.Ala137Ser pepQ_p.Ala137Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine pepQ p.Ala141Glu pepQ_p.Ala141Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1140 1319 False False Inf 0.534232413570953 Inf 0 0 0.00546625270429624 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 213 4734 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 503 572 False False 0 0 0 0 0 0 0 Inf 0.56721266938512 Inf 0 0 0.0171695765109405 1 0.999221072542716 1 1 3) Uncertain significance New Uncertain no 0 +Clofazimine pepQ p.Ala153Gly pepQ_p.Ala153Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Clofazimine pepQ p.Ala16Gly pepQ_p.Ala16Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine pepQ p.Ala187Glu pepQ_p.Ala187Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 674 14039 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1139 1319 False False 0 0 31.5916386345298 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine pepQ p.Ala227Asp pepQ_p.Ala227Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine pepQ p.Ala242Thr pepQ_p.Ala242Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 674 14038 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 22.7684048554448 1 169 1319 False False 0 0 22.7684048554448 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 14 3) Uncertain significance No change no 1 +Clofazimine pepQ p.Ala254Thr pepQ_p.Ala254Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 802.34555512305 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 851.098742087123 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 1 3) Uncertain significance No change no 1 +Clofazimine pepQ p.Ala263Val pepQ_p.Ala263Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Clofazimine pepQ p.Ala305Val pepQ_p.Ala305Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Clofazimine pepQ p.Ala370Val pepQ_p.Ala370Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Clofazimine pepQ p.Ala90Val pepQ_p.Ala90Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 5 3) Uncertain significance No change no 1 +Clofazimine pepQ p.Arg170Trp pepQ_p.Arg170Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine pepQ p.Arg278Gly pepQ_p.Arg278Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine pepQ p.Arg61Cys pepQ_p.Arg61Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1145 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine pepQ p.Arg7Gln pepQ_p.Arg7Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 10 1 9 1 10 673 14033 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.99928790144556 0.998690816610614 0.99965846992849 0.0909090909090909 0.00229897221381426 0.412779916988382 0.1 0.00252857854446178 0.445016117028195 0.0909090909090909 0.00229897221381426 0.412779916988382 2.31682350998844 0.0527805844469789 16.7579254433143 0.374354790615774 122 1319 False False 2.08514115898959 0.0479768321599935 14.6913291611026 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.99928790144556 0.998690816610614 0.99965846992849 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 1 6 1 6 213 4728 0.00467289719626168 0.000118300515887328 0.0257593138532706 0.998732572877059 0.997243401195562 0.999534739052189 0.142857142857142 0.00361029686190058 0.578723197043195 0.142857142857142 0.00361029686190058 0.578723197043195 0.142857142857142 0.00361029686190058 0.578723197043195 3.69953051643192 0.080057182127365 30.6876971693897 0.266320234201229 58 572 False False 0 0 0 0 0 0 0 3.69953051643192 0.080057182127365 30.6876971693897 0.00467289719626168 0.000118300515887328 0.0257593138532706 0.998732572877059 0.997243401195562 0.999534739052189 37 3) Uncertain significance No change no 1 +Clofazimine pepQ p.Arg86_Gly88del pepQ_p.Arg86_Gly88del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine pepQ p.Asn118Asp pepQ_p.Asn118Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Clofazimine pepQ p.Asp108Asn pepQ_p.Asp108Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1143 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine pepQ p.Asp209Glu pepQ_p.Asp209Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine pepQ p.Asp20Gly pepQ_p.Asp20Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 13 3) Uncertain significance New Uncertain no 0 +Clofazimine pepQ p.Asp232fs pepQ_p.Asp232fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.534232413570953 Inf 0.0457973771828497 55 1319 False False Inf 0.534232413570953 Inf 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim UP from Uncertain to AwRI no 4 +Clofazimine pepQ p.Asp26Ala pepQ_p.Asp26Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1136 1319 False False Inf 0.534232413570953 Inf 0 0 0.00546625270429624 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Clofazimine pepQ p.Asp26Gly pepQ_p.Asp26Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 802.34555512305 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 502 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance No change no 1 +Clofazimine pepQ p.Asp51fs pepQ_p.Asp51fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 6 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim New AwRI no 5 +Clofazimine pepQ p.Gln262Arg pepQ_p.Gln262Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 3 3) Uncertain significance New Uncertain no 0 +Clofazimine pepQ p.Gln5Arg pepQ_p.Gln5Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1146 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine pepQ p.Gln63Arg pepQ_p.Gln63Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine pepQ p.Glu177Asp pepQ_p.Glu177Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine pepQ p.Glu191Val pepQ_p.Glu191Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine pepQ p.Glu360Asp pepQ_p.Glu360Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine pepQ p.Glu76Asp pepQ_p.Glu76Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine pepQ p.Glu89Asp pepQ_p.Glu89Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine pepQ p.Gly112Asp pepQ_p.Gly112Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine pepQ p.Gly197Arg pepQ_p.Gly197Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 28 5 23 5 23 669 14020 0.00741839762611276 0.00241299320385175 0.0172265646313554 0.998362173324788 0.99754346318125 0.99896148392623 0.178571428571428 0.0606429088192075 0.368933349419203 0.178571428571428 0.0606429088192075 0.368933349419203 0.178571428571428 0.0606429088192075 0.368933349419203 4.55579385195294 1.34836083888208 12.2998873341084 0.00811957809772142 24 1319 False False 4.55579385195294 1.34836083888208 12.2998873341084 0.00741839762611276 0.00241299320385175 0.0172265646313554 0.998362173324788 0.99754346318125 0.99896148392623 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 43 3) Uncertain significance No change no 1 +Clofazimine pepQ p.Gly291Ser pepQ_p.Gly291Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine pepQ p.Gly41Asp pepQ_p.Gly41Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1135 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine pepQ p.Gly80Arg pepQ_p.Gly80Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.534232413570953 Inf 0.0457973771828497 55 1319 False False Inf 0.534232413570953 Inf 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine pepQ p.Gly85Cys pepQ_p.Gly85Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine pepQ p.His100fs pepQ_p.His100fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1142 1319 False False Inf 0.534232413570953 Inf 0 0 0.00546625270429624 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim New AwRI no 5 +Clofazimine pepQ p.Ile193Thr pepQ_p.Ile193Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 674 14037 0 0 0.00545816471080279 0.999572740867336 0.999070270474308 0.999843187804675 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 17.7219093583043 1 169 1319 False False 0 0 17.7219093583043 0 0 0.00545816471080279 0.999572740867336 0.999070270474308 0.999843187804675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 118.033875066473 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 2 3) Uncertain significance No change no 1 +Clofazimine pepQ p.Ile193Val pepQ_p.Ile193Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine pepQ p.Ile24Thr pepQ_p.Ile24Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine pepQ p.Ile28Arg pepQ_p.Ile28Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine pepQ p.Leu107Arg pepQ_p.Leu107Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine pepQ p.Leu179Pro pepQ_p.Leu179Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine pepQ p.Leu317fs pepQ_p.Leu317fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim New AwRI no 5 +Clofazimine pepQ p.Lys350Glu pepQ_p.Lys350Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine pepQ p.Lys367Asn pepQ_p.Lys367Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine pepQ p.Lys94Asn pepQ_p.Lys94Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine pepQ p.Met180Thr pepQ_p.Met180Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1141 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine pepQ p.Met180Val pepQ_p.Met180Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Clofazimine pepQ p.Phe46Leu pepQ_p.Phe46Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 16 0 16 0 16 674 14027 0 0 0.00545816471080279 0.998860642312896 0.998150412174592 0.999348622824847 0 0 0.205907214207822 0 0 0.205907214207822 0 0 0.205907214207822 0 0 5.41012600327403 1 619 1319 False False 0 0 5.41012600327403 0 0 0.00545816471080279 0.998860642312896 0.998150412174592 0.999348622824847 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 7 3) Uncertain significance No change no 1 +Clofazimine pepQ p.Pro165Gln pepQ_p.Pro165Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine pepQ p.Pro266Ser pepQ_p.Pro266Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine pepQ p.Pro69Leu pepQ_p.Pro69Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 33 0 33 0 36 674 14007 0 0 0.00545816471080279 0.997436445204016 0.996452708846449 0.998203891572429 0 0 0.0973937559144919 0 0 0.105762810074579 0 0 0.0973937559144919 0 0 2.46456170959273 0.403391036091896 127 1319 False False 0 0 2.248665525849 0 0 0.00545816471080279 0.997436445204016 0.996452708846449 0.998203891572429 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 25 0 25 0 26 214 4708 0 0 0.0170900343744659 0.994507815800591 0.99196296324579 0.996409279410029 0 0 0.132274604497754 0 0 0.137185171530712 0 0 0.132274604497754 0 0 3.52715608758615 0.624944876518957 59 572 False False 0 0 0 0 0 0 0 0 0 3.38161324065848 0 0 0.0170900343744659 0.994507815800591 0.99196296324579 0.996409279410029 151 3) Uncertain significance No change no 1 +Clofazimine pepQ p.Ser130Leu pepQ_p.Ser130Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine pepQ p.Ser66Leu pepQ_p.Ser66Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine pepQ p.Ser99Arg pepQ_p.Ser99Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1138 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 500 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 3 3) Uncertain significance No change no 1 +Clofazimine pepQ p.Thr341Ala pepQ_p.Thr341Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1147 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 3) Uncertain significance No change no 1 +Clofazimine pepQ p.Thr354Ala pepQ_p.Thr354Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 14 3) Uncertain significance No change no 1 +Clofazimine pepQ p.Val101Leu pepQ_p.Val101Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine pepQ p.Val104Leu pepQ_p.Val104Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 50.4845768710802 1 619 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine pepQ p.Val158Met pepQ_p.Val158Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance New Uncertain no 0 +Clofazimine pepQ p.Val273fs pepQ_p.Val273fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 673 14042 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999928790144556 0.999603308654684 0.999998197124178 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1137 1319 False False 20.8647845468053 0.265412371331172 1613.44310281692 0 0 0.00546625270429624 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim New AwRI no 5 +Clofazimine pepQ p.Val298Ile pepQ_p.Val298Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 674 14039 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 31.5916386345298 1 619 1319 False False 0 0 31.5916386345298 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 118.033875066473 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 8 3) Uncertain significance No change no 1 +Clofazimine pepQ p.Val30Leu pepQ_p.Val30Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine pepQ p.Val324Met pepQ_p.Val324Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine pepQ p.Val328Phe pepQ_p.Val328Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine pepQ p.Val343Ala pepQ_p.Val343Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine pepQ p.Val45Leu pepQ_p.Val45Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 12 0 12 1 17 673 14026 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.998789432457452 0.998062469319839 0.999294646641111 0.0555555555555555 0.00140555616736942 0.272943599673368 0 0 0.264648469397051 0 0 0.195064322969093 0 0 7.51640549171378 1 619 1319 False False 1.22594178830521 0.0292914408017913 7.84699797474892 0 0 0.00546625270429624 0.998789432457452 0.998062469319839 0.999294646641111 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 501 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 6 3) Uncertain significance No change no 1 +Clofazimine pepQ p.Val53Met pepQ_p.Val53Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance No change no 1 +Clofazimine Rv0678 c.108G>T Rv0678_c.108G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv0678 c.111T>C Rv0678_c.111T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 674 14038 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 22.7684048554448 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 214 4731 0 0 0.0170900343744659 0.999366286438529 0.998149147855346 0.999869293957204 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 53.7295049630073 NA NA NA NA NA NA 22 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv0678 c.127C>T Rv0678_c.127C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv0678 c.138T>C Rv0678_c.138T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv0678 c.168G>A Rv0678_c.168G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv0678 c.189C>T Rv0678_c.189C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv0678 c.195G>A Rv0678_c.195G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 118.033875066473 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv0678 c.1G>T Rv0678_c.1G>T 1 initiator_codon_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv0678 c.297T>G Rv0678_c.297T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv0678 c.309C>T Rv0678_c.309C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv0678 c.318A>G Rv0678_c.318A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 25 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv0678 c.363G>A Rv0678_c.363G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 674 14039 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.5916386345298 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 214 4730 0 0 0.0170900343744659 0.999155048584706 0.997838014616212 0.999769732715123 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 33.6387430781262 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv0678 c.36C>T Rv0678_c.36C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv0678 c.375G>A Rv0678_c.375G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv0678 c.384C>A Rv0678_c.384C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 118.033875066473 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv0678 c.390G>C Rv0678_c.390G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 674 14038 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 22.7684048554448 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 21 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv0678 c.408G>A Rv0678_c.408G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv0678 c.435T>C Rv0678_c.435T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv0678 c.441G>A Rv0678_c.441G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv0678 c.447C>T Rv0678_c.447C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv0678 c.460C>T Rv0678_c.460C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv0678 c.81C>T Rv0678_c.81C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv0678 c.87C>T Rv0678_c.87C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv0678 LoF Rv0678_LoF 1 LoF (see "Genomic_coordinates" sheet) 1 164 64 100 93 148 581 13895 0.137982195845697 0.112834816137449 0.166347362859716 0.989460941394289 0.987631085821989 0.991083485253649 0.385892116182572 0.324102454031338 0.450525638890408 0.390243902439024 0.315146029518894 0.469384354582867 0.30188679245283 0.240899349205264 0.368512381122447 15.3060240963855 10.8751874710541 21.3936417714852 3.73520850858338e-44 1 1319 True False 15.0280853142298 11.3082029843483 19.871212596447 0.0992248062015504 0.0772554477975556 0.124939565147102 0.989460941394289 0.987631085821989 0.991083485253649 3) Uncertain significance 1) Assoc w R WHO 1) Assoc w R 1 116 54 62 63 68 151 4666 0.294392523364485 0.234229064868912 0.360353763120611 0.985635825940008 0.98182507991721 0.988828853873223 0.480916030534351 0.39284969014784 0.569864308501348 0.46551724137931 0.372380525484109 0.560457059234134 0.442622950819672 0.352771552280109 0.535325522199811 26.9134800256355 17.6367727447619 40.8091267112937 1.0726332297648e-45 1 572 True False 0 0 0 0 0 0 0 28.6285547331515 19.1936708889109 42.4727613979758 0.263414634146341 0.204502228792622 0.329307338072748 0.985635825940008 0.98182507991721 0.988828853873223 NA Marker of R 1) Assoc w R Can only confer resistance if genetically linked to a functional MmpL5 New AwR yes E 5 +Clofazimine Rv0678 p.Ala101Glu Rv0678_p.Ala101Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Ala102Asp Rv0678_p.Ala102Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.534232413570953 Inf 0.0457973771828497 55 1319 False False Inf 0.534232413570953 Inf 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 213 4734 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.56721266938512 Inf 0.0432497978981406 34 572 False False 0 0 0 0 0 0 0 Inf 0.56721266938512 Inf 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv0678 p.Ala102Thr Rv0678_p.Ala102Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 672 14043 0.0029673590504451 0.000359563182310977 0.0106776554748576 1 0.999737349925893 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 3.91661217545325 Inf 0.00209443020141736 16.5 1319 False False Inf 3.91661217545325 Inf 0.0029673590504451 0.000359563182310977 0.0106776554748576 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 212 4734 0.00934579439252336 0.00113382977970066 0.0333506066446319 1 0.999221072542716 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 4.16553496523236 Inf 0.00186218050380108 11.5 572 False False 0 0 0 0 0 0 0 Inf 4.16553496523236 Inf 0.00934579439252336 0.00113382977970066 0.0333506066446319 1 0.999221072542716 1 1 3) Uncertain significance New Uncertain AwRI by relaxed thresholds (not endorsed) and BDQ cross-R yes P 0 +Clofazimine Rv0678 p.Ala110fs Rv0678_p.Ala110fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.534232413570953 Inf 0.0457973771828497 55 1319 False False Inf 0.534232413570953 Inf 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Clofazimine Rv0678 p.Ala110Val Rv0678_p.Ala110Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv0678 p.Ala112Ser Rv0678_p.Ala112Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv0678 p.Ala124Pro Rv0678_p.Ala124Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Ala144fs Rv0678_p.Ala144fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Clofazimine Rv0678 p.Ala36Val Rv0678_p.Ala36Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 3 1 671 14042 0.00445103857566765 0.00091885344774779 0.0129522747681396 0.999928790144556 0.999603308654684 0.999998197124178 0.75 0.194120449683243 0.99369053679029 1 0.158113883008419 1 0.666666666666666 0.0942993240502461 0.991596241340387 Inf 3.92221412826969 Inf 0.00208878297548764 12 1319 False False 62.7809239940387 5.02764872629121 3218.12831600541 0.00297176820208023 0.000360097752794557 0.0106934596481595 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 212 4734 0.00934579439252336 0.00113382977970066 0.0333506066446319 1 0.999221072542716 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 4.16553496523236 Inf 0.00186218050380108 11.5 572 False False 0 0 0 0 0 0 0 Inf 4.16553496523236 Inf 0.00934579439252336 0.00113382977970066 0.0333506066446319 1 0.999221072542716 1 4 BDQ-CFZ cross-resistance 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 UP from Uncertain to AwRI yes BDQ-CFZ X-R E 4 +Clofazimine Rv0678 p.Ala59Val Rv0678_p.Ala59Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Ala62fs Rv0678_p.Ala62fs 1 frameshift (see "Genomic_coordinates" sheet) 1 3 1 2 1 2 673 14041 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999857580289112 0.999485626730555 0.999982751846902 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 10.4316493313521 0.176556008630772 200.333455094347 0.131204488725157 100 1319 False False 10.4316493313521 0.176556008630772 200.333455094347 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 1 2 213 4732 0.00467289719626168 0.000118300515887328 0.0257593138532706 0.999577524292353 0.998474714407054 0.999948832136202 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 11.1079812206572 0.187407717913085 213.598932938617 0.124242670676105 52.5 572 False False 0 0 0 0 0 0 0 11.1079812206572 0.187407717913085 213.598932938617 0.00467289719626168 0.000118300515887328 0.0257593138532706 0.999577524292353 0.998474714407054 0.999948832136202 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Clofazimine Rv0678 p.Ala62Thr Rv0678_p.Ala62Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.534232413570953 Inf 0.0457973771828497 55 1319 False False Inf 0.534232413570953 Inf 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Ala84Thr Rv0678_p.Ala84Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 50.4845768710802 1 619 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 214 4731 0 0 0.0170900343744659 0.999366286438529 0.998149147855346 0.999869293957204 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 53.7295049630073 1 83 572 False False 0 0 0 0 0 0 0 0 0 53.7295049630073 0 0 0.0170900343744659 0.999366286438529 0.998149147855346 0.999869293957204 NA 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Ala84Val Rv0678_p.Ala84Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 802.34555512305 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 851.098742087123 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 2 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Ala86Val Rv0678_p.Ala86Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv0678 p.Ala99Pro Rv0678_p.Ala99Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1171 1319 False False Inf 0.534232413570953 Inf 0 0 0.00546625270429624 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) and BDQ cross-R yes P 1 +Clofazimine Rv0678 p.Arg107Cys Rv0678_p.Arg107Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain AwRI by relaxed thresholds (not endorsed) and BDQ cross-R yes P 0 +Clofazimine Rv0678 p.Arg109fs Rv0678_p.Arg109fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 UP from Uncertain to AwRI no E 4 +Clofazimine Rv0678 p.Arg109Leu Rv0678_p.Arg109Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv0678 p.Arg132fs Rv0678_p.Arg132fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1165 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Clofazimine Rv0678 p.Arg134Gly Rv0678_p.Arg134Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 674 14038 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 22.7684048554448 1 169 1319 False False 0 0 22.7684048554448 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv0678 p.Arg156fs Rv0678_p.Arg156fs 1 frameshift (see "Genomic_coordinates" sheet) 1 5 1 4 1 4 673 14039 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999715160578224 0.999270860010958 0.999922385565456 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 5.21508172362555 0.105739966047978 52.7265413991935 0.208977451290434 113.5 1319 False False 5.21508172362555 0.105739966047978 52.7265413991935 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999715160578224 0.999270860010958 0.999922385565456 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 1 3 1 3 213 4731 0.00467289719626168 0.000118300515887328 0.0257593138532706 0.999366286438529 0.998149147855346 0.999869293957204 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 7.4037558685446 0.140378463696898 92.7502763441399 0.162141976737847 55 572 False False 0 0 0 0 0 0 0 7.4037558685446 0.140378463696898 92.7502763441399 0.00467289719626168 0.000118300515887328 0.0257593138532706 0.999366286438529 0.998149147855346 0.999869293957204 5 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Clofazimine Rv0678 p.Arg156Gln Rv0678_p.Arg156Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Arg156* Rv0678_p.Arg156* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.534232413570953 Inf 0.0457973771828497 55 1319 False False Inf 0.534232413570953 Inf 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 213 4734 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.56721266938512 Inf 0.0432497978981406 34 572 False False 0 0 0 0 0 0 0 Inf 0.56721266938512 Inf 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 3 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Clofazimine Rv0678 p.Arg30fs Rv0678_p.Arg30fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.534232413570953 Inf 0.0457973771828497 55 1319 False False Inf 0.534232413570953 Inf 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 213 4734 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.56721266938512 Inf 0.0432497978981406 34 572 False False 0 0 0 0 0 0 0 Inf 0.56721266938512 Inf 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Clofazimine Rv0678 p.Arg30Trp Rv0678_p.Arg30Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1166 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 511 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv0678 p.Arg38* Rv0678_p.Arg38* 1 stop_gained (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 674 14039 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 31.5916386345298 1 619 1319 False False 0 0 31.5916386345298 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 214 4730 0 0 0.0170900343744659 0.999155048584706 0.997838014616212 0.999769732715123 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 33.6387430781262 1 83 572 False False 0 0 0 0 0 0 0 0 0 33.6387430781262 0 0 0.0170900343744659 0.999155048584706 0.997838014616212 0.999769732715123 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 UP from Uncertain to AwRI no E 4 +Clofazimine Rv0678 p.Arg50dup Rv0678_p.Arg50dup 1 inframe_insertion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Arg50Gln Rv0678_p.Arg50Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 672 14043 0.0029673590504451 0.000359563182310977 0.0106776554748576 1 0.999737349925893 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 3.91661217545325 Inf 0.00209443020141736 16.5 1319 False False Inf 3.91661217545325 Inf 0.0029673590504451 0.000359563182310977 0.0106776554748576 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain AwRI by relaxed thresholds (not endorsed) and BDQ cross-R yes P 0 +Clofazimine Rv0678 p.Arg50Trp Rv0678_p.Arg50Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.534232413570953 Inf 0.0457973771828497 55 1319 False False Inf 0.534232413570953 Inf 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 213 4734 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.56721266938512 Inf 0.0432497978981406 34 572 False False 0 0 0 0 0 0 0 Inf 0.56721266938512 Inf 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 2 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv0678 p.Arg72fs Rv0678_p.Arg72fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1176 1319 False False Inf 0.534232413570953 Inf 0 0 0.00546625270429624 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Clofazimine Rv0678 p.Arg72Gln Rv0678_p.Arg72Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1152 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 507 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Arg72Trp Rv0678_p.Arg72Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 1 2 673 14041 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999857580289112 0.999485626730555 0.999982751846902 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 10.4316493313521 0.176556008630772 200.333455094347 0.131204488725157 100 1319 False False 10.4316493313521 0.176556008630772 200.333455094347 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 213 4733 0.00467289719626168 0.000118300515887328 0.0257593138532706 0.999788762146176 0.998823626139438 0.999994651934878 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 22.2206572769953 0.281762968762878 1716.65162034476 0.0846374152924802 49.5 572 False False 0 0 0 0 0 0 0 22.2206572769953 0.281762968762878 1716.65162034476 0.00467289719626168 0.000118300515887328 0.0257593138532706 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Arg89Gln Rv0678_p.Arg89Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.534232413570953 Inf 0.0457973771828497 55 1319 False False Inf 0.534232413570953 Inf 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 213 4734 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.56721266938512 Inf 0.0432497978981406 34 572 False False 0 0 0 0 0 0 0 Inf 0.56721266938512 Inf 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 2 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv0678 p.Arg89Leu Rv0678_p.Arg89Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.534232413570953 Inf 0.0457973771828497 55 1319 False False Inf 0.534232413570953 Inf 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 213 4734 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.56721266938512 Inf 0.0432497978981406 34 572 False False 0 0 0 0 0 0 0 Inf 0.56721266938512 Inf 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv0678 p.Arg89Trp Rv0678_p.Arg89Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 118.033875066473 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 1 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv0678 p.Arg90Cys Rv0678_p.Arg90Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 1 7 2 8 672 14035 0.0029673590504451 0.000359563182310977 0.0106776554748576 0.999430321156448 0.998877815823723 0.99975402204924 0.2 0.0252107263268333 0.556095462307641 0.125 0.0031597235312519 0.526509670875206 0.111111111111111 0.00280913674659921 0.482496514917337 2.98363095238095 0.0661040805858443 23.2742487225159 0.312440958209443 118 1319 False False 5.22135416666666 0.539031035042888 26.2294023620711 0.00148588410104011 3.7618620758983e-05 0.00825075228183891 0.999430321156448 0.998877815823723 0.99975402204924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 213 4733 0.00467289719626168 0.000118300515887328 0.0257593138532706 0.999788762146176 0.998823626139438 0.999994651934878 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 855.219368442451 1 279.5 572 False False 0 0 0 0 0 0 0 22.2206572769953 0.281762968762878 1716.65162034476 0 0 0.0171695765109405 0.999788762146176 0.998823626139438 0.999994651934878 2 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Arg94Gln Rv0678_p.Arg94Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.534232413570953 Inf 0.0457973771828497 55 1319 False False Inf 0.534232413570953 Inf 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 213 4734 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.56721266938512 Inf 0.0432497978981406 34 572 False False 0 0 0 0 0 0 0 Inf 0.56721266938512 Inf 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv0678 p.Arg94Trp Rv0678_p.Arg94Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) and BDQ cross-R yes P 1 +Clofazimine Rv0678 p.Arg96Gly Rv0678_p.Arg96Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 2 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Arg96Leu Rv0678_p.Arg96Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv0678 p.Arg96Trp Rv0678_p.Arg96Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 802.34555512305 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 2 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Asn148His Rv0678_p.Asn148His 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 118.033875066473 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 1 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Asn4Thr Rv0678_p.Asn4Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 10 1 9 5 9 669 14034 0.00741839762611276 0.00241299320385175 0.0172265646313554 0.999359111301004 0.998783743811125 0.999706904333134 0.357142857142857 0.127598429859159 0.648619889384008 0.1 0.00252857854446178 0.445016117028195 0.1 0.00252857854446178 0.445016117028195 2.33084205281514 0.0530994815636042 16.8595857763646 0.372630780891146 121 1319 False False 11.6542102640757 3.05800440581018 38.8286242293342 0.00149253731343283 3.77870591619749e-05 0.00828756997282798 0.999359111301004 0.998783743811125 0.999706904333134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 1 4 5 4 209 4730 0.0233644859813084 0.00762892209478334 0.0536797306785133 0.999155048584706 0.997838014616212 0.999769732715123 0.555555555555555 0.212008506778868 0.863004337734833 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 5.6578947368421 0.114345672523074 57.4592660114122 0.195159232780018 56 572 False False 0 0 0 0 0 0 0 28.2894736842105 6.02637433663145 143.222750052292 0.00476190476190476 0.000120553723217226 0.0262446357302904 0.999155048584706 0.997838014616212 0.999769732715123 11 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Asn70Asp Rv0678_p.Asn70Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 672 14043 0.0029673590504451 0.000359563182310977 0.0106776554748576 1 0.999737349925893 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1172 1319 False False Inf 3.91661217545325 Inf 0 0 0.00547436470313033 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 BDQ-CFZ cross-resistance 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI yes BDQ-CFZ X-R E 5 +Clofazimine Rv0678 p.Asn70fs Rv0678_p.Asn70fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.534232413570953 Inf 0.0457973771828497 55 1319 False False Inf 0.534232413570953 Inf 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 213 4734 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.56721266938512 Inf 0.0432497978981406 34 572 False False 0 0 0 0 0 0 0 Inf 0.56721266938512 Inf 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Clofazimine Rv0678 p.Asn70Ile Rv0678_p.Asn70Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 673 14042 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999928790144556 0.999603308654684 0.999998197124178 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 20.8647845468053 0.265412371331172 1613.44310281692 0.0895003241642821 90 1319 False False 20.8647845468053 0.265412371331172 1613.44310281692 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 213 4733 0.00467289719626168 0.000118300515887328 0.0257593138532706 0.999788762146176 0.998823626139438 0.999994651934878 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 22.2206572769953 0.281762968762878 1716.65162034476 0.0846374152924802 49.5 572 False False 0 0 0 0 0 0 0 22.2206572769953 0.281762968762878 1716.65162034476 0.00467289719626168 0.000118300515887328 0.0257593138532706 0.999788762146176 0.998823626139438 0.999994651934878 2 3) Uncertain significance New Uncertain AwRI by relaxed thresholds (not endorsed) and BDQ cross-R yes P 0 +Clofazimine Rv0678 p.Asn70Lys Rv0678_p.Asn70Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.534232413570953 Inf 0.0457973771828497 55 1319 False False Inf 0.534232413570953 Inf 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 213 4734 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.56721266938512 Inf 0.0432497978981406 34 572 False False 0 0 0 0 0 0 0 Inf 0.56721266938512 Inf 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv0678 p.Asn98Asp Rv0678_p.Asn98Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 0 8 674 14035 0 0 0.00545816471080279 0.999430321156448 0.998877815823723 0.99975402204924 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 12.2229935310233 1 1043.5 1319 False False 0 0 12.2229935310233 0 0 0.00545816471080279 0.999430321156448 0.998877815823723 0.99975402204924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Asn98fs Rv0678_p.Asn98fs 1 frameshift (see "Genomic_coordinates" sheet) 1 4 1 3 1 3 673 14040 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999786370433668 0.999375811939756 0.999955942280632 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 6.95393759286775 0.132268015542041 86.681794653799 0.171001156837107 107 1319 False False 6.95393759286775 0.132268015542041 86.681794653799 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 1 2 213 4732 0.00467289719626168 0.000118300515887328 0.0257593138532706 0.999577524292353 0.998474714407054 0.999948832136202 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 11.1079812206572 0.187407717913085 213.598932938617 0.124242670676105 52.5 572 False False 0 0 0 0 0 0 0 11.1079812206572 0.187407717913085 213.598932938617 0.00467289719626168 0.000118300515887328 0.0257593138532706 0.999577524292353 0.998474714407054 0.999948832136202 17 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 UP from Uncertain to AwRI no E 4 +Clofazimine Rv0678 p.Asp116fs Rv0678_p.Asp116fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1153 1319 False False Inf 0.534232413570953 Inf 0 0 0.00546625270429624 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Clofazimine Rv0678 p.Asp141fs Rv0678_p.Asp141fs 1 frameshift (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 674 14039 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 50.4809680276667 1 619 1319 False False 0 0 31.5916386345298 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 UP from Uncertain to AwRI no E 4 +Clofazimine Rv0678 p.Asp15Gly Rv0678_p.Asp15Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 50.4845768710802 1 619 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 214 4731 0 0 0.0170900343744659 0.999366286438529 0.998149147855346 0.999869293957204 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 53.7295049630073 1 83 572 False False 0 0 0 0 0 0 0 0 0 53.7295049630073 0 0 0.0170900343744659 0.999366286438529 0.998149147855346 0.999869293957204 5 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Asp165fs Rv0678_p.Asp165fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.534232413570953 Inf 0.0457973771828497 55 1319 False False Inf 0.534232413570953 Inf 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Clofazimine Rv0678 p.Asp47fs Rv0678_p.Asp47fs 1 frameshift (see "Genomic_coordinates" sheet) 1 24 10 14 17 22 657 14021 0.0252225519287833 0.0147601677413708 0.0400773474961125 0.998433383180232 0.997629078392245 0.999017957301543 0.435897435897435 0.278107629676409 0.603791982985728 0.416666666666666 0.221096905346678 0.633569354343637 0.3125 0.1611847240882 0.500077581632169 15.2435312024353 6.02964171534013 37.0161177669372 3.8025986558369e-08 4 1319 True False 16.4907292099072 8.1756137389351 32.6974395918418 0.0149925037481259 0.0072122859788508 0.0273984591313972 0.998433383180232 0.997629078392245 0.999017957301543 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 19 9 10 10 11 204 4723 0.0467289719626168 0.0226327221083927 0.084255290187164 0.997676383607942 0.995846220600476 0.998839506172504 0.476190476190476 0.257130626406406 0.702193161216357 0.473684210526315 0.244474689466196 0.711356752083001 0.45 0.230577896775924 0.684721866959451 20.8367647058823 7.38759600994601 57.6754804432286 2.73549748492093e-08 3 572 True False 0 0 0 0 0 0 0 21.0472370766488 7.89771402260014 55.1926893460714 0.0422535211267605 0.0195002632388286 0.0786924451751214 0.997676383607942 0.995846220600476 0.998839506172504 66 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 UP from Uncertain to AwRI no E 4 +Clofazimine Rv0678 p.Asp5Asn Rv0678_p.Asp5Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv0678 p.Asp5Gly Rv0678_p.Asp5Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 24 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv0678 p.Asp8fs Rv0678_p.Asp8fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Clofazimine Rv0678 p.Asp8Gly Rv0678_p.Asp8Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv0678 p.Cys46_Asp47insGly Rv0678_p.Cys46_Asp47insGly 1 inframe_insertion (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1158 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 510 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Cys46Arg Rv0678_p.Cys46Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 3 0 3 0 671 14043 0.00445103857566765 0.00091885344774779 0.0129522747681396 1 0.999737349925893 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 8.62656082946124 Inf 9.56477808598346e-05 9.5 1319 True False Inf 8.62656082946124 Inf 0.00445103857566765 0.00091885344774779 0.0129522747681396 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 212 4734 0.00934579439252336 0.00113382977970066 0.0333506066446319 1 0.999221072542716 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 4.16553496523236 Inf 0.00186218050380108 11.5 572 False False 0 0 0 0 0 0 0 Inf 4.16553496523236 Inf 0.00934579439252336 0.00113382977970066 0.0333506066446319 1 0.999221072542716 1 10 BDQ-CFZ cross-resistance 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI yes BDQ-CFZ X-R E 5 +Clofazimine Rv0678 p.Cys46fs Rv0678_p.Cys46fs 1 frameshift (see "Genomic_coordinates" sheet) 1 3 2 1 3 1 671 14042 0.00445103857566765 0.00091885344774779 0.0129522747681396 0.999928790144556 0.999603308654684 0.999998197124178 0.75 0.194120449683243 0.99369053679029 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 41.8539493293591 2.17423524473306 2422.41193157873 0.00607501436197819 22 1319 False False 62.7809239940387 5.02764872629121 3218.12831600541 0.00297176820208023 0.000360097752794557 0.0106934596481595 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 2 1 2 1 212 4733 0.00934579439252336 0.00113382977970066 0.0333506066446319 0.999788762146176 0.998823626139438 0.999994651934878 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 44.6509433962264 2.308987944757 2580.78641290913 0.00542690452523024 16.5 572 False False 0 0 0 0 0 0 0 44.6509433962264 2.308987944757 2580.78641290913 0.00934579439252336 0.00113382977970066 0.0333506066446319 0.999788762146176 0.998823626139438 0.999994651934878 11 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Clofazimine Rv0678 p.Cys46Gly Rv0678_p.Cys46Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1173 1319 False False Inf 0.534232413570953 Inf 0 0 0.00546625270429624 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Cys46Tyr Rv0678_p.Cys46Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.534232413570953 Inf 0.0457973771828497 55 1319 False False Inf 0.534232413570953 Inf 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 213 4734 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.56721266938512 Inf 0.0432497978981406 34 572 False False 0 0 0 0 0 0 0 Inf 0.56721266938512 Inf 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv0678 p.Gln115* Rv0678_p.Gln115* 1 stop_gained (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 111.092568149139 1 169 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 3 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 UP from Uncertain to AwRI no E 4 +Clofazimine Rv0678 p.Gln22Arg Rv0678_p.Gln22Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Gln22Pro Rv0678_p.Gln22Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1163 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv0678 p.Gln22* Rv0678_p.Gln22* 1 stop_gained (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 50.4845768710802 1 619 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 214 4731 0 0 0.0170900343744659 0.999366286438529 0.998149147855346 0.999869293957204 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 53.7295049630073 1 83 572 False False 0 0 0 0 0 0 0 0 0 53.7295049630073 0 0 0.0170900343744659 0.999366286438529 0.998149147855346 0.999869293957204 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Clofazimine Rv0678 p.Gln51Arg Rv0678_p.Gln51Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 3 0 3 0 671 14043 0.00445103857566765 0.00091885344774779 0.0129522747681396 1 0.999737349925893 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 8.62656082946124 Inf 9.56477808598346e-05 9.5 1319 True False Inf 8.62656082946124 Inf 0.00445103857566765 0.00091885344774779 0.0129522747681396 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Gln51Lys Rv0678_p.Gln51Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Gln51Pro Rv0678_p.Gln51Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 672 14043 0.0029673590504451 0.000359563182310977 0.0106776554748576 1 0.999737349925893 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 3.91661217545325 Inf 0.00209443020141736 16.5 1319 False False Inf 3.91661217545325 Inf 0.0029673590504451 0.000359563182310977 0.0106776554748576 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 212 4734 0.00934579439252336 0.00113382977970066 0.0333506066446319 1 0.999221072542716 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 4.16553496523236 Inf 0.00186218050380108 11.5 572 False False 0 0 0 0 0 0 0 Inf 4.16553496523236 Inf 0.00934579439252336 0.00113382977970066 0.0333506066446319 1 0.999221072542716 1 1 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv0678 p.Gln76Arg Rv0678_p.Gln76Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 118.033875066473 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 1 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv0678 p.Gln76Glu Rv0678_p.Gln76Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 118.033875066473 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 1 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Gln76* Rv0678_p.Gln76* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Clofazimine Rv0678 p.Glu104Asp Rv0678_p.Glu104Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv0678 p.Glu104Gly Rv0678_p.Glu104Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1148 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Glu104Lys Rv0678_p.Glu104Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 802.34555512305 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 851.098742087123 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 1 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv0678 p.Glu113Lys Rv0678_p.Glu113Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Glu113* Rv0678_p.Glu113* 1 stop_gained (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1151 1319 False False Inf 0.534232413570953 Inf 0 0 0.00546625270429624 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 UP from Uncertain to AwRI no E 4 +Clofazimine Rv0678 p.Glu138* Rv0678_p.Glu138* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.534232413570953 Inf 0.0457973771828497 55 1319 False False Inf 0.534232413570953 Inf 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 213 4734 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.56721266938512 Inf 0.0432497978981406 34 572 False False 0 0 0 0 0 0 0 Inf 0.56721266938512 Inf 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Clofazimine Rv0678 p.Glu147Asp Rv0678_p.Glu147Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1174 1319 False False Inf 0.534232413570953 Inf 0 0 0.00546625270429624 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv0678 p.Glu21Lys Rv0678_p.Glu21Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Glu49fs Rv0678_p.Glu49fs 1 frameshift (see "Genomic_coordinates" sheet) 1 40 20 20 29 30 645 14013 0.043026706231454 0.0290019295032209 0.0612113378981269 0.99786370433668 0.996951698182168 0.998558200432382 0.491525423728813 0.358912727800532 0.625017450265023 0.5 0.338017813737234 0.661982186262765 0.4 0.264078395094536 0.548205971520819 21.7255813953488 11.0218656728044 42.7138418708377 5.75123162088925e-17 3 1319 True False 21.0013953488372 12.0755048309502 36.4161783850377 0.0300751879699248 0.0184654738632356 0.0460677952051118 0.99786370433668 0.996951698182168 0.998558200432382 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 26 16 10 18 13 196 4721 0.0841121495327102 0.0506122519397806 0.129675998290047 0.997253907900295 0.995308676874106 0.998537036545967 0.580645161290322 0.390759222492092 0.754524049261348 0.615384615384615 0.405707535298591 0.797739756344979 0.551724137931034 0.356938710803913 0.735544696293295 38.538775510204 16.152591374369 96.1872397625616 2.7258434728799e-16 2 572 True False 0 0 0 0 0 0 0 33.3508634222919 15.160724757049 74.9836798468262 0.0754716981132075 0.0437521898394145 0.119669155719685 0.997253907900295 0.995308676874106 0.998537036545967 147 1) Assoc w R Can only confer resistance if genetically linked to a functional MmpL5 UP from Uncertain to AwR yes E 4 +Clofazimine Rv0678 p.Glu54Lys Rv0678_p.Glu54Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Glu55Asp Rv0678_p.Glu55Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 16 2 14 2 14 672 14029 0.0029673590504451 0.000359563182310977 0.0106776554748576 0.999003062023784 0.998327872643959 0.99945486094574 0.125 0.0155136038154138 0.383476236849263 0.125 0.0155136038154138 0.383476236849263 0.125 0.0155136038154138 0.383476236849263 2.98235544217687 0.328285357744054 13.0244091215043 0.164886260848905 105 1319 False False 2.98235544217687 0.328285357744054 13.0244091215043 0.0029673590504451 0.000359563182310977 0.0106776554748576 0.999003062023784 0.998327872643959 0.99945486094574 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 214 4730 0 0 0.0170900343744659 0.999155048584706 0.997838014616212 0.999769732715123 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 33.6387430781262 1 83 572 False False 0 0 0 0 0 0 0 0 0 33.6387430781262 0 0 0.0170900343744659 0.999155048584706 0.997838014616212 0.999769732715123 13 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Gly103Ser Rv0678_p.Gly103Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 673 14042 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999928790144556 0.999603308654684 0.999998197124178 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 20.8647845468053 0.265412371331172 1613.44310281692 0.0895003241642821 90 1319 False False 20.8647845468053 0.265412371331172 1613.44310281692 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Gly11fs Rv0678_p.Gly11fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1159 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 UP from Uncertain to AwRI no E 4 +Clofazimine Rv0678 p.Gly121Arg Rv0678_p.Gly121Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 4 1 4 1 670 14042 0.0059347181008902 0.00161930788766713 0.0151250012595154 0.999928790144556 0.999603308654684 0.999998197124178 0.8 0.28358206388191 0.994949236620532 0.8 0.28358206388191 0.994949236620532 0.8 0.28358206388191 0.994949236620532 83.8328358208955 8.26973843876709 4010.50104375612 2.10145345620822e-05 6 1319 True False 83.8328358208955 8.26973843876709 4010.50104375612 0.0059347181008902 0.00161930788766713 0.0151250012595154 0.999928790144556 0.999603308654684 0.999998197124178 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance 1 3 2 1 2 1 212 4733 0.00934579439252336 0.00113382977970066 0.0333506066446319 0.999788762146176 0.998823626139438 0.999994651934878 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 44.6509433962264 2.308987944757 2580.78641290913 0.00542690452523024 16.5 572 False False 0 0 0 0 0 0 0 44.6509433962264 2.308987944757 2580.78641290913 0.00934579439252336 0.00113382977970066 0.0333506066446319 0.999788762146176 0.998823626139438 0.999994651934878 6 Evidence from ALL dataset only 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI yes ALL only E 5 +Clofazimine Rv0678 p.Gly162Glu Rv0678_p.Gly162Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 8 674 14035 0 0 0.00545816471080279 0.999430321156448 0.998877815823723 0.99975402204924 0 0 0.369416647552819 0 0 0.4592581264399 0 0 0.369416647552819 0 0 17.7193865201983 1 169 1319 False False 0 0 12.2229935310233 0 0 0.00545816471080279 0.999430321156448 0.998877815823723 0.99975402204924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 8 214 4726 0 0 0.0170900343744659 0.998310097169412 0.996672947522823 0.999270146456405 0 0 0.369416647552819 0 0 0.4592581264399 0 0 0.369416647552819 0 0 18.8667613870558 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 13.0211752369257 0 0 0.0170900343744659 0.998310097169412 0.996672947522823 0.999270146456405 9 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Gly25Asp Rv0678_p.Gly25Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1149 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 505 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 2 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv0678 p.Gly25Cys Rv0678_p.Gly25Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Gly41fs Rv0678_p.Gly41fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1160 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Clofazimine Rv0678 p.Gly65Arg Rv0678_p.Gly65Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.534232413570953 Inf 0.0457973771828497 55 1319 False False Inf 0.534232413570953 Inf 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 213 4734 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.56721266938512 Inf 0.0432497978981406 34 572 False False 0 0 0 0 0 0 0 Inf 0.56721266938512 Inf 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv0678 p.Gly78Trp Rv0678_p.Gly78Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv0678 p.Gly87Arg Rv0678_p.Gly87Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 111.092568149139 1 169 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 851.098742087123 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 23 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Gly87Trp Rv0678_p.Gly87Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv0678 p.Ile108Thr Rv0678_p.Ile108Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 802.34555512305 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Ile108Val Rv0678_p.Ile108Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 673 14041 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999857580289112 0.999485626730555 0.999982751846902 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 803.522779598282 1 619 1319 False False 10.4316493313521 0.176556008630772 200.333455094347 0 0 0.00546625270429624 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 213 4734 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 508 572 False False 0 0 0 0 0 0 0 Inf 0.56721266938512 Inf 0 0 0.0171695765109405 1 0.999221072542716 1 NA 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Ile16fs Rv0678_p.Ile16fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.534232413570953 Inf 0.0457973771828497 55 1319 False False Inf 0.534232413570953 Inf 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 213 4734 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.56721266938512 Inf 0.0432497978981406 34 572 False False 0 0 0 0 0 0 0 Inf 0.56721266938512 Inf 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Clofazimine Rv0678 p.Ile67fs Rv0678_p.Ile67fs 1 frameshift (see "Genomic_coordinates" sheet) 1 26 9 17 12 39 662 14004 0.0178041543026706 0.00923265298726782 0.0308935791754901 0.997222815637684 0.996205433099122 0.998024427803654 0.235294117647058 0.127908100251827 0.374930508359858 0.346153846153846 0.172144138005666 0.55667192604239 0.1875 0.0894983818493728 0.326293023956713 11.1992180558023 4.37950480249508 26.6665545181302 1.27158051710047e-06 5 1319 True False 6.50894724610736 3.08672485184845 12.7572031233172 0.0134128166915052 0.00615104430513499 0.0253084542158361 0.997222815637684 0.996205433099122 0.998024427803654 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 17 8 9 10 10 204 4724 0.0467289719626168 0.0226327221083927 0.084255290187164 0.997887621461766 0.996118702879007 0.998986582156994 0.5 0.271957849560791 0.728042150439208 0.470588235294117 0.22983268726599 0.721881699668893 0.444444444444444 0.215301507387299 0.692428341001244 20.5838779956427 6.82056320247663 60.559543706155 1.74368765371112e-07 4 572 True False 0 0 0 0 0 0 0 23.156862745098 8.52581521335176 62.6928916394735 0.0377358490566037 0.0164300564269374 0.0729980513276394 0.997887621461766 0.996118702879007 0.998986582156994 132 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Clofazimine Rv0678 p.Ile67Leu Rv0678_p.Ile67Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) and BDQ cross-R yes P 1 +Clofazimine Rv0678 p.Ile67Ser Rv0678_p.Ile67Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1155 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 12 BDQ-CFZ cross-resistance 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 UP from Uncertain to AwRI yes BDQ-CFZ X-R E 4 +Clofazimine Rv0678 p.Ile75Val Rv0678_p.Ile75Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1179 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 515 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Ile80fs Rv0678_p.Ile80fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 UP from Uncertain to AwRI no E 4 +Clofazimine Rv0678 p.Ile80Met Rv0678_p.Ile80Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Ile80Ser Rv0678_p.Ile80Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1150 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 506 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Leu117Arg Rv0678_p.Leu117Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 13 4 9 4 9 670 14034 0.0059347181008902 0.00161930788766713 0.0151250012595154 0.999359111301004 0.998783743811125 0.999706904333134 0.307692307692307 0.0909203945720966 0.614261661750705 0.307692307692307 0.0909203945720966 0.614261661750705 0.307692307692307 0.0909203945720966 0.614261661750705 9.3094527363184 2.08869771173996 33.418284868862 0.00223787913103687 21 1319 False False 9.3094527363184 2.08869771173996 33.418284868862 0.0059347181008902 0.00161930788766713 0.0151250012595154 0.999359111301004 0.998783743811125 0.999706904333134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 3 6 3 6 211 4728 0.014018691588785 0.00290037436233909 0.0404197483900649 0.998732572877059 0.997243401195562 0.999534739052189 0.333333333333333 0.0748546314196918 0.700704943791459 0.333333333333333 0.0748546314196918 0.700704943791459 0.333333333333333 0.0748546314196918 0.700704943791459 11.2037914691943 1.79830435440079 52.7609401969196 0.00552172438242446 18 572 False False 0 0 0 0 0 0 0 11.2037914691943 1.79830435440079 52.7609401969196 0.014018691588785 0.00290037436233909 0.0404197483900649 0.998732572877059 0.997243401195562 0.999534739052189 16 BDQ-CFZ cross-resistance 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 UP from Uncertain to AwRI yes BDQ-CFZ X-R E 4 +Clofazimine Rv0678 p.Leu117Pro Rv0678_p.Leu117Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1175 1319 False False Inf 0.534232413570953 Inf 0 0 0.00546625270429624 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 213 4734 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 513 572 False False 0 0 0 0 0 0 0 Inf 0.56721266938512 Inf 0 0 0.0171695765109405 1 0.999221072542716 1 3 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv0678 p.Leu125fs Rv0678_p.Leu125fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 UP from Uncertain to AwRI no E 4 +Clofazimine Rv0678 p.Leu142Arg Rv0678_p.Leu142Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 672 14043 0.0029673590504451 0.000359563182310977 0.0106776554748576 1 0.999737349925893 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.53502626143815 Inf 0.0457325360152215 27.5 1319 False False Inf 3.91661217545325 Inf 0.00148588410104011 3.7618620758983e-05 0.00825075228183891 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 213 4734 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.56721266938512 Inf 0.0432497978981406 34 572 False False 0 0 0 0 0 0 0 Inf 0.56721266938512 Inf 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 8 3) Uncertain significance New Uncertain AwRI by relaxed thresholds (not endorsed) and BDQ cross-R yes P 0 +Clofazimine Rv0678 p.Leu142fs Rv0678_p.Leu142fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 802.289132424172 1 619 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 17 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Clofazimine Rv0678 p.Leu32fs Rv0678_p.Leu32fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 4 0 670 14043 0.0059347181008902 0.00161930788766713 0.0151250012595154 1 0.999737349925893 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 1170 1319 False False Inf 13.7930869748905 Inf 0 0 0.00549066114558213 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 0 210 4734 0.0186915887850467 0.00511573452207981 0.0471638210086244 1 0.999221072542716 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 512 572 False False 0 0 0 0 0 0 0 Inf 14.743484119673 Inf 0 0 0.0174127082678636 1 0.999221072542716 1 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Clofazimine Rv0678 p.Leu32Ser Rv0678_p.Leu32Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 1 3 1 3 673 14040 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999786370433668 0.999375811939756 0.999955942280632 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 6.95393759286775 0.132268015542041 86.681794653799 0.171001156837107 107 1319 False False 6.95393759286775 0.132268015542041 86.681794653799 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 1 2 213 4732 0.00467289719626168 0.000118300515887328 0.0257593138532706 0.999577524292353 0.998474714407054 0.999948832136202 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 11.1079812206572 0.187407717913085 213.598932938617 0.124242670676105 52.5 572 False False 0 0 0 0 0 0 0 11.1079812206572 0.187407717913085 213.598932938617 0.00467289719626168 0.000118300515887328 0.0257593138532706 0.999577524292353 0.998474714407054 0.999948832136202 5 BDQ-CFZ cross-resistance 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 UP from Uncertain to AwRI yes BDQ-CFZ X-R E 4 +Clofazimine Rv0678 p.Leu35Trp Rv0678_p.Leu35Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 672 14043 0.0029673590504451 0.000359563182310977 0.0106776554748576 1 0.999737349925893 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 3.91661217545325 Inf 0.00209443020141736 16.5 1319 False False Inf 3.91661217545325 Inf 0.0029673590504451 0.000359563182310977 0.0106776554748576 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 212 4734 0.00934579439252336 0.00113382977970066 0.0333506066446319 1 0.999221072542716 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 4.16553496523236 Inf 0.00186218050380108 11.5 572 False False 0 0 0 0 0 0 0 Inf 4.16553496523236 Inf 0.00934579439252336 0.00113382977970066 0.0333506066446319 1 0.999221072542716 1 NA 3) Uncertain significance New Uncertain AwRI by relaxed thresholds (not endorsed) and BDQ cross-R yes P 0 +Clofazimine Rv0678 p.Leu40Met Rv0678_p.Leu40Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv0678 p.Leu40Phe Rv0678_p.Leu40Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.534232413570953 Inf 0.0457973771828497 55 1319 False False Inf 0.534232413570953 Inf 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain AwRI by relaxed thresholds (not endorsed) and BDQ cross-R yes P 0 +Clofazimine Rv0678 p.Leu40Ser Rv0678_p.Leu40Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Leu40Val Rv0678_p.Leu40Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 10 0 10 0 10 674 14033 0 0 0.00545816471080279 0.99928790144556 0.998690816610614 0.99965846992849 0 0 0.30849710781876 0 0 0.30849710781876 0 0 0.30849710781876 0 0 9.30775405122037 1 169 1319 False False 0 0 9.30775405122037 0 0 0.00545816471080279 0.99928790144556 0.998690816610614 0.99965846992849 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Leu44fs Rv0678_p.Leu44fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Clofazimine Rv0678 p.Leu56fs Rv0678_p.Leu56fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.534232413570953 Inf 0.0457973771828497 55 1319 False False Inf 0.534232413570953 Inf 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 213 4734 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.56721266938512 Inf 0.0432497978981406 34 572 False False 0 0 0 0 0 0 0 Inf 0.56721266938512 Inf 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Clofazimine Rv0678 p.Leu56Pro Rv0678_p.Leu56Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.534232413570953 Inf 0.0457973771828497 55 1319 False False Inf 0.534232413570953 Inf 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 213 4734 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.56721266938512 Inf 0.0432497978981406 34 572 False False 0 0 0 0 0 0 0 Inf 0.56721266938512 Inf 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv0678 p.Leu60Gln Rv0678_p.Leu60Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance New Uncertain AwRI by relaxed thresholds (not endorsed) and BDQ cross-R yes P 0 +Clofazimine Rv0678 p.Leu74Met Rv0678_p.Leu74Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv0678 p.Leu83His Rv0678_p.Leu83His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv0678 p.Leu83Phe Rv0678_p.Leu83Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Leu83Pro Rv0678_p.Leu83Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 672 14043 0.0029673590504451 0.000359563182310977 0.0106776554748576 1 0.999737349925893 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.53502626143815 Inf 0.0457325360152215 27.5 1319 False False Inf 3.91661217545325 Inf 0.00148588410104011 3.7618620758983e-05 0.00825075228183891 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Leu95Ser Rv0678_p.Leu95Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 118.033875066473 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 2 3) Uncertain significance New Uncertain AwRI by relaxed thresholds (not endorsed) and BDQ cross-R yes P 0 +Clofazimine Rv0678 p.Met1? Rv0678_p.Met1? 1 start_lost (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 5 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Clofazimine Rv0678 p.Met10fs Rv0678_p.Met10fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 UP from Uncertain to AwRI no E 4 +Clofazimine Rv0678 p.Met10Ile Rv0678_p.Met10Ile 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.534232413570953 Inf 0.0457973771828497 55 1319 False False Inf 0.534232413570953 Inf 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv0678 p.Met111fs Rv0678_p.Met111fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 UP from Uncertain to AwRI no E 4 +Clofazimine Rv0678 p.Met111Thr Rv0678_p.Met111Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1156 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 509 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Met139Ile Rv0678_p.Met139Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 3 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) and BDQ cross-R yes P 1 +Clofazimine Rv0678 p.Met146Thr Rv0678_p.Met146Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 37 2 35 2 36 672 14007 0.0029673590504451 0.000359563182310977 0.0106776554748576 0.997436445204016 0.996452708846449 0.998203891572429 0.0526315789473684 0.00643871671509191 0.17749059034764 0.054054054054054 0.00661457041152882 0.181949118377749 0.0526315789473684 0.00643871671509191 0.17749059034764 1.19107142857142 0.138512499412389 4.65293798726387 0.686489202474462 139 1319 False False 1.15798611111111 0.134772612784794 4.51446571604761 0.0029673590504451 0.000359563182310977 0.0106776554748576 0.997436445204016 0.996452708846449 0.998203891572429 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 514 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 29 BDQ-CFZ cross-resistance 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 UP from Uncertain to AwRI yes BDQ-CFZ X-R E 4 +Clofazimine Rv0678 p.Met17Val Rv0678_p.Met17Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 111.092568149139 1 169 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Met23Val Rv0678_p.Met23Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 674 14039 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 31.5916386345298 1 619 1319 False False 0 0 31.5916386345298 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Met73Ile Rv0678_p.Met73Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 50.4845768710802 1 619 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Phe19Leu Rv0678_p.Phe19Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv0678 p.Phe19Ser Rv0678_p.Phe19Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.534232413570953 Inf 0.0457973771828497 55 1319 False False Inf 0.534232413570953 Inf 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv0678 p.Phe93Leu Rv0678_p.Phe93Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 118.033875066473 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 4 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) and BDQ cross-R yes P 1 +Clofazimine Rv0678 p.Phe93Ser Rv0678_p.Phe93Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv0678 p.Pro129fs Rv0678_p.Pro129fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.534232413570953 Inf 0.0457973771828497 55 1319 False False Inf 0.534232413570953 Inf 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 213 4734 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.56721266938512 Inf 0.0432497978981406 34 572 False False 0 0 0 0 0 0 0 Inf 0.56721266938512 Inf 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 3 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Clofazimine Rv0678 p.Pro14Leu Rv0678_p.Pro14Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1162 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Pro14Ser Rv0678_p.Pro14Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1161 1319 False False Inf 0.534232413570953 Inf 0 0 0.00546625270429624 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Pro48fs Rv0678_p.Pro48fs 1 frameshift (see "Genomic_coordinates" sheet) 1 4 3 1 3 2 671 14041 0.00445103857566765 0.00091885344774779 0.0129522747681396 0.999857580289112 0.999485626730555 0.999982751846902 0.6 0.146632799634673 0.947255049473683 0.75 0.194120449683243 0.99369053679029 0.6 0.146632799634673 0.947255049473683 62.7764530551415 5.02729067919864 3217.90532754861 0.000369580143775836 11 1319 True False 31.3882265275707 3.58598009676545 374.022606672895 0.00445103857566765 0.00091885344774779 0.0129522747681396 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 3 0 3 0 211 4734 0.014018691588785 0.00290037436233909 0.0404197483900649 1 0.999221072542716 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 9.19614074929596 Inf 7.98184930865003e-05 7 572 True False 0 0 0 0 0 0 0 Inf 9.19614074929596 Inf 0.014018691588785 0.00290037436233909 0.0404197483900649 1 0.999221072542716 1 18 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Clofazimine Rv0678 p.Pro48Leu Rv0678_p.Pro48Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 1 2 673 14041 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999857580289112 0.999485626730555 0.999982751846902 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 10.4316493313521 0.176556008630772 200.333455094347 0.131204488725157 100 1319 False False 10.4316493313521 0.176556008630772 200.333455094347 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 213 4734 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.56721266938512 Inf 0.0432497978981406 34 572 False False 0 0 0 0 0 0 0 Inf 0.56721266938512 Inf 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 2 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) and BDQ cross-R yes P 1 +Clofazimine Rv0678 p.Ser151Pro Rv0678_p.Ser151Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 672 14043 0.0029673590504451 0.000359563182310977 0.0106776554748576 1 0.999737349925893 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 3.91661217545325 Inf 0.00209443020141736 16.5 1319 False False Inf 3.91661217545325 Inf 0.0029673590504451 0.000359563182310977 0.0106776554748576 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 212 4734 0.00934579439252336 0.00113382977970066 0.0333506066446319 1 0.999221072542716 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 4.16553496523236 Inf 0.00186218050380108 11.5 572 False False 0 0 0 0 0 0 0 Inf 4.16553496523236 Inf 0.00934579439252336 0.00113382977970066 0.0333506066446319 1 0.999221072542716 1 1 3) Uncertain significance New Uncertain AwRI by relaxed thresholds (not endorsed) and BDQ cross-R yes P 0 +Clofazimine Rv0678 p.Ser158Arg Rv0678_p.Ser158Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 802.34555512305 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 516 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Ser2Arg Rv0678_p.Ser2Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 50.4845768710802 1 619 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Ser2Ile Rv0678_p.Ser2Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1177 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) and BDQ cross-R yes P 1 +Clofazimine Rv0678 p.Ser31Gly Rv0678_p.Ser31Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv0678 p.Ser52Phe Rv0678_p.Ser52Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.534232413570953 Inf 0.0457973771828497 55 1319 False False Inf 0.534232413570953 Inf 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 213 4734 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.56721266938512 Inf 0.0432497978981406 34 572 False False 0 0 0 0 0 0 0 Inf 0.56721266938512 Inf 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 2 3) Uncertain significance New Uncertain AwRI by relaxed thresholds (not endorsed) and BDQ cross-R yes P 0 +Clofazimine Rv0678 p.Ser52Pro Rv0678_p.Ser52Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Ser52Tyr Rv0678_p.Ser52Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.534232413570953 Inf 0.0457973771828497 55 1319 False False Inf 0.534232413570953 Inf 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 213 4734 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.56721266938512 Inf 0.0432497978981406 34 572 False False 0 0 0 0 0 0 0 Inf 0.56721266938512 Inf 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv0678 p.Ser53Leu Rv0678_p.Ser53Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 4 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv0678 p.Ser53Pro Rv0678_p.Ser53Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 3 0 4 0 670 14043 0.0059347181008902 0.00161930788766713 0.0151250012595154 1 0.999737349925893 1 1 0.397635364383525 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 8.63949035600358 Inf 9.52414634786769e-05 8 1319 True False Inf 13.7930869748905 Inf 0.00445765230312035 0.000920220162195385 0.0129714378400378 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 3 0 4 0 210 4734 0.0186915887850467 0.00511573452207981 0.0471638210086244 1 0.999221072542716 1 1 0.397635364383525 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 9.23977375312506 Inf 7.87472871683022e-05 6 572 True False 0 0 0 0 0 0 0 Inf 14.743484119673 Inf 0.0140845070422535 0.00291403565409614 0.0406069389981492 1 0.999221072542716 1 1 3) Uncertain significance New Uncertain AwRI by relaxed thresholds (not endorsed) and BDQ cross-R yes P 0 +Clofazimine Rv0678 p.Ser64dup Rv0678_p.Ser64dup 1 inframe_insertion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Ser68Asn Rv0678_p.Ser68Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.534232413570953 Inf 0.0457973771828497 55 1319 False False Inf 0.534232413570953 Inf 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv0678 p.Ser68fs Rv0678_p.Ser68fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Clofazimine Rv0678 p.Ser68Gly Rv0678_p.Ser68Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Ser68Ile Rv0678_p.Ser68Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv0678 p.Ter166Argext*? Rv0678_p.Ter166Argext*? 1 stop_lost (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1164 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv0678 p.Thr33Ile Rv0678_p.Thr33Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.534232413570953 Inf 0.0457973771828497 55 1319 False False Inf 0.534232413570953 Inf 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 213 4734 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.56721266938512 Inf 0.0432497978981406 34 572 False False 0 0 0 0 0 0 0 Inf 0.56721266938512 Inf 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv0678 p.Thr58Lys Rv0678_p.Thr58Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Thr58Pro Rv0678_p.Thr58Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1157 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv0678 p.Thr69Pro Rv0678_p.Thr69Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1167 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv0678 p.Trp42Arg Rv0678_p.Trp42Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1168 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Trp42Cys Rv0678_p.Trp42Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 2 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Tyr145His Rv0678_p.Tyr145His 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1178 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv0678 p.Tyr145* Rv0678_p.Tyr145* 1 stop_gained (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 673 14042 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999928790144556 0.999603308654684 0.999998197124178 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 20.8647845468053 0.265412371331172 1613.44310281692 0.0895003241642821 90 1319 False False 20.8647845468053 0.265412371331172 1613.44310281692 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 213 4734 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.56721266938512 Inf 0.0432497978981406 34 572 False False 0 0 0 0 0 0 0 Inf 0.56721266938512 Inf 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Clofazimine Rv0678 p.Tyr157fs Rv0678_p.Tyr157fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 672 14043 0.0029673590504451 0.000359563182310977 0.0106776554748576 1 0.999737349925893 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1154 1319 False False Inf 3.91661217545325 Inf 0 0 0.00547436470313033 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 New AwRI no E 5 +Clofazimine Rv0678 p.Tyr157Ser Rv0678_p.Tyr157Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.534232413570953 Inf 0.0457973771828497 55 1319 False False Inf 0.534232413570953 Inf 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 213 4734 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.56721266938512 Inf 0.0432497978981406 34 572 False False 0 0 0 0 0 0 0 Inf 0.56721266938512 Inf 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 2 3) Uncertain significance New Uncertain AwRI by relaxed thresholds (not endorsed) and BDQ cross-R yes P 0 +Clofazimine Rv0678 p.Tyr26Cys Rv0678_p.Tyr26Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1169 1319 False False Inf 0.534232413570953 Inf 0 0 0.00546625270429624 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Tyr92fs Rv0678_p.Tyr92fs 1 frameshift (see "Genomic_coordinates" sheet) 1 6 2 4 2 5 672 14038 0.0029673590504451 0.000359563182310977 0.0106776554748576 0.99964395072278 0.999169297020829 0.999884381985141 0.285714285714285 0.0366925661760855 0.709579136262657 0.333333333333333 0.0432718682927417 0.777221904496487 0.285714285714285 0.0366925661760855 0.709579136262657 10.4449404761904 0.94285059926755 72.987873640104 0.0277856429896713 25 1319 False False 8.35595238095238 0.794034598155219 51.1554476298512 0.0029673590504451 0.000359563182310977 0.0106776554748576 0.99964395072278 0.999169297020829 0.999884381985141 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 214 4730 0 0 0.0170900343744659 0.999155048584706 0.997838014616212 0.999769732715123 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 53.7180800648943 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 33.6387430781262 0 0 0.0170900343744659 0.999155048584706 0.997838014616212 0.999769732715123 10 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 UP from Uncertain to AwRI no E 4 +Clofazimine Rv0678 p.Val120Met Rv0678_p.Val120Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.534232413570953 Inf 0.0457973771828497 55 1319 False False Inf 0.534232413570953 Inf 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 213 4734 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.56721266938512 Inf 0.0432497978981406 34 572 False False 0 0 0 0 0 0 0 Inf 0.56721266938512 Inf 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 5 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv0678 p.Val20Ala Rv0678_p.Val20Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Val20Gly Rv0678_p.Val20Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 672 14043 0.0029673590504451 0.000359563182310977 0.0106776554748576 1 0.999737349925893 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 3.91661217545325 Inf 0.00209443020141736 16.5 1319 False False Inf 3.91661217545325 Inf 0.0029673590504451 0.000359563182310977 0.0106776554748576 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 212 4734 0.00934579439252336 0.00113382977970066 0.0333506066446319 1 0.999221072542716 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 4.16553496523236 Inf 0.00186218050380108 11.5 572 False False 0 0 0 0 0 0 0 Inf 4.16553496523236 Inf 0.00934579439252336 0.00113382977970066 0.0333506066446319 1 0.999221072542716 1 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv0678 p.Val7del Rv0678_p.Val7del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv0678 p.Val7fs Rv0678_p.Val7fs 1 frameshift (see "Genomic_coordinates" sheet) 1 11 5 6 5 6 669 14037 0.00741839762611276 0.00241299320385175 0.0172265646313554 0.999572740867336 0.999070270474308 0.999843187804675 0.454545454545454 0.167488094063707 0.766206402340654 0.454545454545454 0.167488094063707 0.766206402340654 0.454545454545454 0.167488094063707 0.766206402340654 17.4850523168908 4.20744500861509 68.9416453924916 7.28276218345978e-05 7 1319 True False 17.4850523168908 4.20744500861509 68.9416453924916 0.00741839762611276 0.00241299320385175 0.0172265646313554 0.999572740867336 0.999070270474308 0.999843187804675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 5 5 5 5 209 4729 0.0233644859813084 0.00762892209478334 0.0536797306785133 0.998943810730883 0.997536942130593 0.999656972101492 0.5 0.187086028447398 0.812913971552601 0.5 0.187086028447398 0.812913971552601 0.5 0.187086028447398 0.812913971552601 22.6267942583732 5.1536726359531 99.2487332777576 3.04795300070642e-05 5 572 True False 0 0 0 0 0 0 0 22.6267942583732 5.1536726359531 99.2487332777576 0.0233644859813084 0.00762892209478334 0.0536797306785133 0.998943810730883 0.997536942130593 0.999656972101492 10 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim Can only confer resistance if genetically linked to a functional MmpL5 UP from Uncertain to AwRI no E 4 +Clofazimine Rv0678 p.Val85Ala Rv0678_p.Val85Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.1006C>T Rv1979c_c.1006C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 11 673 14032 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999216691590116 0.998598878125098 0.999608912470572 0.0833333333333333 0.00210759323186022 0.384796165150944 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.8954477914359 0.0439714145636034 13.0725475783332 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 11 213 4723 0.00467289719626168 0.000118300515887328 0.0257593138532706 0.997676383607942 0.995846220600476 0.998839506172504 0.0833333333333333 0.00210759323186022 0.384796165150944 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.01579172001707 0.046615645726345 13.980028654064 NA NA NA NA NA NA 11 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.1035A>G Rv1979c_c.1035A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 27 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.1041C>T Rv1979c_c.1041C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.-106C>T Rv1979c_c.-106C>T 1 upstream_gene_variant 2223270 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c c.-107G>A Rv1979c_c.-107G>A 1 upstream_gene_variant 2223271 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.-10C>T Rv1979c_c.-10C>T 1 upstream_gene_variant 2223174 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.1104G>T Rv1979c_c.1104G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.-111delC Rv1979c_c.-111delC 1 upstream_gene_variant 2223274 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.1122G>A Rv1979c_c.1122G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.1129C>T Rv1979c_c.1129C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.534232413570953 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.1140C>T Rv1979c_c.1140C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.-114G>A Rv1979c_c.-114G>A 1 upstream_gene_variant 2223278 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.1176T>G Rv1979c_c.1176T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.-120C>T Rv1979c_c.-120C>T 1 upstream_gene_variant 2223284 1 3 0 3 0 5 674 14038 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 50.4773591941261 1 619 1319 False False 0 0 22.7684048554448 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 118.033875066473 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 20 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.-123G>T Rv1979c_c.-123G>T 1 upstream_gene_variant 2223287 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.1254G>A Rv1979c_c.1254G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 50.4845768710802 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.1254G>T Rv1979c_c.1254G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.-125G>C Rv1979c_c.-125G>C 1 upstream_gene_variant 2223289 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c c.1282C>T Rv1979c_c.1282C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.1296C>T Rv1979c_c.1296C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.-129A>G Rv1979c_c.-129A>G 1 upstream_gene_variant 2223293 1 7 2 5 658 13833 16 210 0.976261127596439 0.96173523542864 0.98637170876682 0.0149540696432386 0.0130120884914838 0.0171006265259516 0.0454074943068111 0.0420747819140549 0.0489242202350569 0.285714285714285 0.0366925661760855 0.709579136262657 0.000144560896277556 1.7507474680858e-05 0.000522105068370827 5.25 0.459346989796129 34.8662628626088 0.0939871729228029 NA NA False True 0.624322272825851 0.372752758138346 1.1192313059337 0.111111111111111 0.0137512156643644 0.347120438608672 0.0149540696432386 0.0130120884914838 0.0171006265259516 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 207 4713 7 21 0.967289719626168 0.933768398626526 0.98674954693322 0.0044359949302915 0.00274798450013965 0.00677293714862914 0.0420731707317073 0.0366352203776163 0.0480625487098963 NA NA NA 0 0 0.000782396813515332 NA NA NA NA NA NA False True 1 1 1 0 0 1 0 0.131763208147676 0.0532289051155416 0.371572218593346 0 0 0.409616397225003 0.0044359949302915 0.00274798450013965 0.00677293714862914 36941 Not assoc w R 5) Not assoc w R No change yes 1 +Clofazimine Rv1979c c.-13_-12insC Rv1979c_c.-13_-12insC 1 upstream_gene_variant 2223176 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.1302C>T Rv1979c_c.1302C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.-130A>C Rv1979c_c.-130A>C 1 upstream_gene_variant 2223294 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.1317A>G Rv1979c_c.1317A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 673 14041 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999857580289112 0.999485626730555 0.999982751846902 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 10.4316493313521 0.176556008630772 200.333455094347 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.1320G>A Rv1979c_c.1320G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.1329T>G Rv1979c_c.1329T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.-133G>C Rv1979c_c.-133G>C 1 upstream_gene_variant 2223297 2 6 1 5 1 5 673 14038 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.99964395072278 0.999169297020829 0.999884381985141 0.166666666666666 0.00421074451448947 0.641234578997674 0.166666666666666 0.00421074451448947 0.641234578997674 0.166666666666666 0.00421074451448947 0.641234578997674 4.17176820208023 0.0880732176054642 37.3482568099296 0.245216521289771 115.5 1319 False False 4.17176820208023 0.0880732176054642 37.3482568099296 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.99964395072278 0.999169297020829 0.999884381985141 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 488 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 2 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.1350T>G Rv1979c_c.1350T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.1440T>G Rv1979c_c.1440T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 674 14039 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.5916386345298 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 214 4730 0 0 0.0170900343744659 0.999155048584706 0.997838014616212 0.999769732715123 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 33.6387430781262 NA NA NA NA NA NA 11 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.1443C>T Rv1979c_c.1443C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 12 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.-154A>G Rv1979c_c.-154A>G 1 upstream_gene_variant 2223318 1 12 1 11 1 11 673 14032 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999216691590116 0.998598878125098 0.999608912470572 0.0833333333333333 0.00210759323186022 0.384796165150944 0.0833333333333333 0.00210759323186022 0.384796165150944 0.0833333333333333 0.00210759323186022 0.384796165150944 1.8954477914359 0.0439714145636034 13.0725475783332 0.430368832445553 129 1319 False False 1.8954477914359 0.0439714145636034 13.0725475783332 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999216691590116 0.998598878125098 0.999608912470572 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 43 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.-160G>A Rv1979c_c.-160G>A 1 upstream_gene_variant 2223324 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1126 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 494 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.165C>T Rv1979c_c.165C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 0 672 14043 0.0029673590504451 0.000359563182310977 0.0106776554748576 1 0.999737349925893 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 3.91661217545325 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.-168A>C Rv1979c_c.-168A>C 1 upstream_gene_variant 2223332 1 0 0 0 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1124 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.-168A>G Rv1979c_c.-168A>G 1 upstream_gene_variant 2223332 1 5 0 5 0 5 674 14038 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 22.7684048554448 1 169 1319 False False 0 0 22.7684048554448 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 214 4729 0 0 0.0170900343744659 0.998943810730883 0.997536942130593 0.999656972101492 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 24.2508634033673 1 83 572 False False 0 0 0 0 0 0 0 0 0 24.2508634033673 0 0 0.0170900343744659 0.998943810730883 0.997536942130593 0.999656972101492 1 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.-16A>C Rv1979c_c.-16A>C 1 upstream_gene_variant 2223180 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.180C>A Rv1979c_c.180C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.183G>A Rv1979c_c.183G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.-186T>G Rv1979c_c.-186T>G 1 upstream_gene_variant 2223350 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.-18C>T Rv1979c_c.-18C>T 1 upstream_gene_variant 2223182 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.18G>A Rv1979c_c.18G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.-191_-187delGATGC Rv1979c_c.-191_-187delGATGC 1 upstream_gene_variant 2223350 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 118.033875066473 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.192C>T Rv1979c_c.192C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.-19G>A Rv1979c_c.-19G>A 1 upstream_gene_variant 2223183 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.-1G>A Rv1979c_c.-1G>A 1 upstream_gene_variant 2223165 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 118.033875066473 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.1G>C Rv1979c_c.1G>C 1 initiator_codon_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.207A>C Rv1979c_c.207A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.-208C>G Rv1979c_c.-208C>G 1 upstream_gene_variant 2223372 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 194 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.-20T>G Rv1979c_c.-20T>G 1 upstream_gene_variant 2223184 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 2 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.-210C>T Rv1979c_c.-210C>T 1 upstream_gene_variant 2223374 1 0 0 0 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1109 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.213C>T Rv1979c_c.213C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.-214G>A Rv1979c_c.-214G>A 1 upstream_gene_variant 2223378 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 2 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.-218A>G Rv1979c_c.-218A>G 1 upstream_gene_variant 2223382 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.-221G>A Rv1979c_c.-221G>A 1 upstream_gene_variant 2223385 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1132 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c c.-234_-217delCCGGCCCAACCCAGGTAT Rv1979c_c.-234_-217delCCGGCCCAACCCAGGTAT 1 upstream_gene_variant 2223380 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c c.234C>G Rv1979c_c.234C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.-235G>T Rv1979c_c.-235G>T 1 upstream_gene_variant 2223399 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.-236A>C Rv1979c_c.-236A>C 1 upstream_gene_variant 2223400 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.240C>T Rv1979c_c.240C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.534232413570953 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 213 4734 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.56721266938512 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.-241G>A Rv1979c_c.-241G>A 1 upstream_gene_variant 2223405 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.249G>A Rv1979c_c.249G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 16 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.-250T>G Rv1979c_c.-250T>G 1 upstream_gene_variant 2223414 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 6 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.-253dupG Rv1979c_c.-253dupG 1 upstream_gene_variant 2223416 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c c.-258C>A Rv1979c_c.-258C>A 1 upstream_gene_variant 2223422 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c c.-258C>T Rv1979c_c.-258C>T 1 upstream_gene_variant 2223422 1 1 0 1 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 802.34555512305 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.-265T>C Rv1979c_c.-265T>C 1 upstream_gene_variant 2223429 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1113 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 486 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.-265T>G Rv1979c_c.-265T>G 1 upstream_gene_variant 2223429 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c c.-26A>C Rv1979c_c.-26A>C 1 upstream_gene_variant 2223190 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.-273T>G Rv1979c_c.-273T>G 1 upstream_gene_variant 2223437 0 0 0 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1127 1319 False False Inf 0.534232413570953 Inf 0 0 0.00546625270429624 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 213 4734 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 495 572 False False 0 0 0 0 0 0 0 Inf 0.56721266938512 Inf 0 0 0.0171695765109405 1 0.999221072542716 1 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c c.-275G>A Rv1979c_c.-275G>A 1 upstream_gene_variant 2223439 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 2 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.-277G>T Rv1979c_c.-277G>T 1 upstream_gene_variant 2223441 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1106 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.-279G>A Rv1979c_c.-279G>A 1 upstream_gene_variant 2223443 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 2 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.-280G>A Rv1979c_c.-280G>A 1 upstream_gene_variant 2223444 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 27 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.-281C>A Rv1979c_c.-281C>A 1 upstream_gene_variant 2223445 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1118 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 112 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c c.-281C>T Rv1979c_c.-281C>T 1 upstream_gene_variant 2223445 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.-283G>A Rv1979c_c.-283G>A 1 upstream_gene_variant 2223447 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1119 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 491 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 2 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.285T>A Rv1979c_c.285T>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.291C>G Rv1979c_c.291C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.-291T>C Rv1979c_c.-291T>C 1 upstream_gene_variant 2223455 1 1 1 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.534232413570953 Inf 0.0457973771828497 55 1319 False False Inf 0.534232413570953 Inf 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c c.-299C>T Rv1979c_c.-299C>T 1 upstream_gene_variant 2223463 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c c.306G>A Rv1979c_c.306G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.312C>T Rv1979c_c.312C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.-315C>T Rv1979c_c.-315C>T 1 upstream_gene_variant 2223479 1 4 0 4 0 4 674 14039 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 31.5916386345298 1 619 1319 False False 0 0 31.5916386345298 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.-322T>C Rv1979c_c.-322T>C 1 upstream_gene_variant 2223486 1 1 1 0 1 1 673 14042 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999928790144556 0.999603308654684 0.999998197124178 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.534194369017788 Inf 0.0458004892633867 82.5 1319 False False 20.8647845468053 0.265412371331172 1613.44310281692 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.-327C>A Rv1979c_c.-327C>A 1 upstream_gene_variant 2223491 0 0 0 0 1 54 673 13989 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.996154667806024 0.994985617310422 0.997109987627261 0.0181818181818181 0.000460217848795697 0.0971910157492533 NA NA NA 0 0 0.0660315142444217 NA NA NA NA 1114 1319 False True 0.384926531286115 0.00955940293653238 2.24537993804172 0 0 0.00546625270429624 0.996154667806024 0.994985617310422 0.997109987627261 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 0 42 214 4692 0 0 0.0170900343744659 0.991128010139417 0.988026377592505 0.993598581339282 0 0 0.0840838549403552 NA NA NA 0 0 0.0840838549403552 NA NA NA NA 487 572 False True 1 1 1 0 0 0 0 0 0 2.03033922761574 0 0 0.0170900343744659 0.991128010139417 0.988026377592505 0.993598581339282 154 5) Not assoc w R UP from Uncertain to NotAwR yes 4 +Clofazimine Rv1979c c.-328G>C Rv1979c_c.-328G>C 1 upstream_gene_variant 2223492 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c c.-328G>T Rv1979c_c.-328G>T 1 upstream_gene_variant 2223492 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.-345T>C Rv1979c_c.-345T>C 1 upstream_gene_variant 2223509 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.-356C>G Rv1979c_c.-356C>G 1 upstream_gene_variant 2223520 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c c.-361_-353delCAGACCGGAinsT Rv1979c_c.-361_-353delCAGACCGGAinsT 1 upstream_gene_variant 2223517 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1133 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.-368G>A Rv1979c_c.-368G>A 1 upstream_gene_variant 2223532 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c c.369C>G Rv1979c_c.369C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.-36G>T Rv1979c_c.-36G>T 1 upstream_gene_variant 2223200 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1110 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 483 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.-378A>G Rv1979c_c.-378A>G 1 upstream_gene_variant 2223542 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.-386C>T Rv1979c_c.-386C>T 1 upstream_gene_variant 2223550 1 12 0 12 0 13 674 14030 0 0 0.00545816471080279 0.999074271879228 0.998417496974718 0.999506999611345 0 0 0.24705263800047 0 0 0.264648469397051 0 0 0.24705263800047 0 0 7.50736868121698 1 169 1319 False False 0 0 6.84763051410409 0 0 0.00545816471080279 0.999074271879228 0.998417496974718 0.999506999611345 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 118.033875066473 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 35 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.387C>T Rv1979c_c.387C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.534232413570953 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.-389C>A Rv1979c_c.-389C>A 1 upstream_gene_variant 2223553 0 0 0 0 3 298 671 13745 0.00445103857566765 0.00091885344774779 0.0129522747681396 0.97877946307769 0.97625861930612 0.981099092896603 0.00996677740863787 0.00206012425404566 0.0288492724818759 NA NA NA 0 0 0.0123024880590161 NA NA NA NA NA NA False True 0.206218305844227 0.0421824843345974 0.611269742304041 0 0 0.00548250081433617 0.97877946307769 0.97625861930612 0.981099092896603 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 1 249 213 4485 0.00467289719626168 0.000118300515887328 0.0257593138532706 0.947401774397972 0.940655957246773 0.953588747278434 0.004 0.00010126610417905 0.0220838650006331 NA NA NA 0 0 0.0147055780339792 NA NA NA NA NA NA False True 1 1 1 0 0 1 0 0.0845636065388313 0.00212654185706012 0.480899773507604 0 0 0.0171695765109405 0.947401774397972 0.940655957246773 0.953588747278434 584 Not assoc w R 5) Not assoc w R No change yes 1 +Clofazimine Rv1979c c.-393T>C Rv1979c_c.-393T>C 1 upstream_gene_variant 2223557 0 0 0 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1128 1319 False False Inf 0.534232413570953 Inf 0 0 0.00546625270429624 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 213 4734 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 496 572 False False 0 0 0 0 0 0 0 Inf 0.56721266938512 Inf 0 0 0.0171695765109405 1 0.999221072542716 1 14 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c c.-398A>G Rv1979c_c.-398A>G 1 upstream_gene_variant 2223562 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.-402T>C Rv1979c_c.-402T>C 1 upstream_gene_variant 2223566 1 3 0 3 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 50.4845768710802 1 619 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.408G>A Rv1979c_c.408G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.-411C>G Rv1979c_c.-411C>G 1 upstream_gene_variant 2223575 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.-426T>G Rv1979c_c.-426T>G 1 upstream_gene_variant 2223590 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.-429C>T Rv1979c_c.-429C>T 1 upstream_gene_variant 2223593 1 1 0 1 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 802.289132424172 1 619 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.42G>A Rv1979c_c.42G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 26 674 14017 0 0 0.00545816471080279 0.998148543758456 0.997288356156613 0.998790221900888 0 0 0.132274604497754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.17883061356028 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 77 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.42G>C Rv1979c_c.42G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.534232413570953 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.-440C>T Rv1979c_c.-440C>T 1 upstream_gene_variant 2223604 1 3 0 3 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 50.4845768710802 1 619 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.-447A>C Rv1979c_c.-447A>C 1 upstream_gene_variant 2223611 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1125 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.-452T>C Rv1979c_c.-452T>C 1 upstream_gene_variant 2223616 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.453C>A Rv1979c_c.453C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.-458G>A Rv1979c_c.-458G>A 1 upstream_gene_variant 2223622 0 0 0 0 2 0 672 14043 0.0029673590504451 0.000359563182310977 0.0106776554748576 1 0.999737349925893 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1104 1319 False False Inf 3.91661217545325 Inf 0 0 0.00547436470313033 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.-461C>A Rv1979c_c.-461C>A 1 upstream_gene_variant 2223625 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c c.465C>T Rv1979c_c.465C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 118.033875066473 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.-49G>A Rv1979c_c.-49G>A 1 upstream_gene_variant 2223213 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.-50A>C Rv1979c_c.-50A>C 1 upstream_gene_variant 2223214 1 52 0 52 0 73 674 13970 0 0 0.00545816471080279 0.994801680552588 0.993468269240872 0.9959231995347 0 0 0.0492770608958592 0 0 0.0684822087033195 0 0 0.0492770608958592 0 0 1.52803977960208 0.175542101433682 109 1319 False False 0 0 1.07734943391044 0 0 0.00545816471080279 0.994801680552588 0.993468269240872 0.9959231995347 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 214 4730 0 0 0.0170900343744659 0.999155048584706 0.997838014616212 0.999769732715123 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 53.7180800648943 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 33.6387430781262 0 0 0.0170900343744659 0.999155048584706 0.997838014616212 0.999769732715123 132 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.546G>T Rv1979c_c.546G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.54C>T Rv1979c_c.54C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.534232413570953 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 0 213 4734 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.56721266938512 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.561C>T Rv1979c_c.561C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 8 674 14035 0 0 0.00545816471080279 0.999430321156448 0.998877815823723 0.99975402204924 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 12.2229935310233 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 8 214 4726 0 0 0.0170900343744659 0.998310097169412 0.996672947522823 0.999270146456405 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 13.0211752369257 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.594G>A Rv1979c_c.594G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 50.4845768710802 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 214 4731 0 0 0.0170900343744659 0.999366286438529 0.998149147855346 0.999869293957204 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 53.7295049630073 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.-59A>G Rv1979c_c.-59A>G 1 upstream_gene_variant 2223223 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c c.612G>T Rv1979c_c.612G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.660T>C Rv1979c_c.660T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.681C>A Rv1979c_c.681C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.687G>A Rv1979c_c.687G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.-68A>G Rv1979c_c.-68A>G 1 upstream_gene_variant 2223232 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1108 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c c.-69G>C Rv1979c_c.-69G>C 1 upstream_gene_variant 2223233 1 6 0 6 0 7 674 14036 0 0 0.00545816471080279 0.999501531011892 0.998973234784508 0.999799566877855 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 17.720647938943 1 619 1319 False False 0 0 14.476435679416 0 0 0.00545816471080279 0.999501531011892 0.998973234784508 0.999799566877855 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 118.033875066473 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 60 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.6C>T Rv1979c_c.6C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 50.4845768710802 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.702T>C Rv1979c_c.702T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.534232413570953 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.-70G>A Rv1979c_c.-70G>A 1 upstream_gene_variant 2223234 1 6 0 6 0 7 674 14036 0 0 0.00545816471080279 0.999501531011892 0.998973234784508 0.999799566877855 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 17.720647938943 1 619 1319 False False 0 0 14.476435679416 0 0 0.00545816471080279 0.999501531011892 0.998973234784508 0.999799566877855 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.741G>T Rv1979c_c.741G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.750G>A Rv1979c_c.750G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.754C>T Rv1979c_c.754C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.777G>A Rv1979c_c.777G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.-78_-67delACAGGCCGGGAG Rv1979c_c.-78_-67delACAGGCCGGGAG 1 upstream_gene_variant 2223230 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.780C>T Rv1979c_c.780C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.802T>C Rv1979c_c.802T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.837G>A Rv1979c_c.837G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.84C>T Rv1979c_c.84C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 0 672 14043 0.0029673590504451 0.000359563182310977 0.0106776554748576 1 0.999737349925893 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 3.91661217545325 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.867G>C Rv1979c_c.867G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.882C>G Rv1979c_c.882C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.-8T>C Rv1979c_c.-8T>C 1 upstream_gene_variant 2223172 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.918C>T Rv1979c_c.918C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 118.033875066473 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.93T>C Rv1979c_c.93T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv1979c c.-96C>T Rv1979c_c.-96C>T 1 upstream_gene_variant 2223260 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c c.-98C>T Rv1979c_c.-98C>T 1 upstream_gene_variant 2223262 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c deletion Rv1979c_deletion 1 feature_ablation (see "Genomic_coordinates" sheet) 1 0 0 0 0 12 674 14031 0 0 0.00545816471080279 0.999145481734672 0.998507804828235 0.999558382465294 0 0 0.264648469397051 NA NA NA 0 0 0.264648469397051 NA NA NA NA 1111 1319 False False 0 0 7.50790373059148 0 0 0.00545816471080279 0.999145481734672 0.998507804828235 0.999558382465294 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 214 4731 0 0 0.0170900343744659 0.999366286438529 0.998149147855346 0.999869293957204 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 484 572 False False 0 0 0 0 0 0 0 0 0 53.7295049630073 0 0 0.0170900343744659 0.999366286438529 0.998149147855346 0.999869293957204 87 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c LoF Rv1979c_LoF 1 LoF (see "Genomic_coordinates" sheet) 1 58 2 56 7 78 667 13965 0.0103857566765578 0.00418552311154975 0.0212809513555928 0.994445631275368 0.993072675979686 0.995607099035376 0.0823529411764705 0.0337525436178748 0.162343904723825 0.0344827586206896 0.00420364723986767 0.119077310880392 0.025 0.00304208616480959 0.0874071559305922 0.747751124437781 0.0881971722316137 2.84102550349073 1 619 1319 False False 1.87896436397186 0.728476477869718 4.07928152529062 0.00298953662182361 0.00036225202497941 0.0107571469644069 0.994445631275368 0.993072675979686 0.995607099035376 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 26 1 25 2 34 212 4700 0.00934579439252336 0.00113382977970066 0.0333506066446319 0.992817912970004 0.98997808665339 0.995021216873519 0.0555555555555555 0.00680030065402281 0.186636706457554 0.0384615384615384 0.00097328789333503 0.196369646762539 0.0285714285714285 0.000723104376338095 0.149172079656431 0.886792452830188 0.0214984802012593 5.47186377243653 1 279.5 572 False False 0 0 0 0 0 0 0 1.30410654827968 0.150821257142342 5.14549194904926 0.00469483568075117 0.000118855884362696 0.025878953838187 0.992817912970004 0.98997808665339 0.995021216873519 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c p.Ala105Asp Rv1979c_p.Ala105Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Ala105Thr Rv1979c_p.Ala105Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 674 14037 0 0 0.00545816471080279 0.999572740867336 0.999070270474308 0.999843187804675 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 17.7219093583043 1 169 1319 False False 0 0 17.7219093583043 0 0 0.00545816471080279 0.999572740867336 0.999070270474308 0.999843187804675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 16 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Ala10Val Rv1979c_p.Ala10Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 7 674 14036 0 0 0.00545816471080279 0.999501531011892 0.998973234784508 0.999799566877855 0 0 0.409616397225003 0 0 0.602364635616474 0 0 0.409616397225003 0 0 31.5852800572818 1 619 1319 False False 0 0 14.476435679416 0 0 0.00545816471080279 0.999501531011892 0.998973234784508 0.999799566877855 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 6 214 4728 0 0 0.0170900343744659 0.998732572877059 0.997243401195562 0.999534739052189 0 0 0.4592581264399 0 0 0.602364635616474 0 0 0.4592581264399 0 0 33.6244666561877 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 18.8747365567989 0 0 0.0170900343744659 0.998732572877059 0.997243401195562 0.999534739052189 8 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Ala121Val Rv1979c_p.Ala121Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c p.Ala126Thr Rv1979c_p.Ala126Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Ala158Thr Rv1979c_p.Ala158Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Ala162fs Rv1979c_p.Ala162fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Ala199Gly Rv1979c_p.Ala199Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c p.Ala202Ser Rv1979c_p.Ala202Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Ala222Thr Rv1979c_p.Ala222Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 30 0 30 0 31 674 14012 0 0 0.00545816471080279 0.997792494481236 0.99686807299094 0.998499629457529 0 0 0.11218874692237 0 0 0.115703308222027 0 0 0.11218874692237 0 0 2.72740536838845 0.401145353344898 124 1319 False False 0 0 2.63412099576211 0 0 0.00545816471080279 0.997792494481236 0.99686807299094 0.998499629457529 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 28 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Ala228Val Rv1979c_p.Ala228Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Ala247Thr Rv1979c_p.Ala247Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Ala247Val Rv1979c_p.Ala247Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 6 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c p.Ala259Glu Rv1979c_p.Ala259Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Ala259Thr Rv1979c_p.Ala259Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 50.4845768710802 1 619 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 214 4731 0 0 0.0170900343744659 0.999366286438529 0.998149147855346 0.999869293957204 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 53.7295049630073 1 83 572 False False 0 0 0 0 0 0 0 0 0 53.7295049630073 0 0 0.0170900343744659 0.999366286438529 0.998149147855346 0.999869293957204 1 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c p.Ala265Val Rv1979c_p.Ala265Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Ala274fs Rv1979c_p.Ala274fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1122 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 492 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Ala298Ser Rv1979c_p.Ala298Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Ala331Val Rv1979c_p.Ala331Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Ala357Val Rv1979c_p.Ala357Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c p.Ala378Thr Rv1979c_p.Ala378Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Ala401Thr Rv1979c_p.Ala401Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Ala405Pro Rv1979c_p.Ala405Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Ala406Thr Rv1979c_p.Ala406Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Ala429fs Rv1979c_p.Ala429fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Ala461Thr Rv1979c_p.Ala461Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Ala461Val Rv1979c_p.Ala461Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c p.Ala47Thr Rv1979c_p.Ala47Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Ala66Ser Rv1979c_p.Ala66Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1129 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Ala66Val Rv1979c_p.Ala66Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1131 1319 False False Inf 0.534232413570953 Inf 0 0 0.00546625270429624 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 213 4734 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 498 572 False False 0 0 0 0 0 0 0 Inf 0.56721266938512 Inf 0 0 0.0171695765109405 1 0.999221072542716 1 1 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c p.Ala84Thr Rv1979c_p.Ala84Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Ala85Gly Rv1979c_p.Ala85Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c p.Arg409Gln Rv1979c_p.Arg409Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 179 55 124 83 136 591 13907 0.123145400593471 0.099289742410153 0.150356538069001 0.990315459659616 0.98855443609085 0.991868574444166 0.378995433789954 0.314493772320973 0.446820922937621 0.307262569832402 0.240596606964193 0.380441231233038 0.287958115183246 0.224877764560375 0.357752233531682 10.4372714371486 7.37143008118124 14.6057073073893 9.8076838282634e-32 2 1319 True False 14.3610157260873 10.6523304374049 19.2469336938654 0.0851393188854489 0.0647810157326464 0.109379758182023 0.990315459659616 0.98855443609085 0.991868574444166 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 2 6 212 4728 0.00934579439252336 0.00113382977970066 0.0333506066446319 0.998732572877059 0.997243401195562 0.999534739052189 0.25 0.0318540262499442 0.650855794412824 0 0 0.4592581264399 0 0 0.4592581264399 0 0 19.0536555337889 1 83 572 False False 0 0 0 0 0 0 0 7.43396226415094 0.728941437868083 41.8561897350835 0 0 0.0172498625165958 0.998732572877059 0.997243401195562 0.999534739052189 500 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Arg441Trp Rv1979c_p.Arg441Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c p.Arg469Leu Rv1979c_p.Arg469Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Arg469* Rv1979c_p.Arg469* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Arg473dup Rv1979c_p.Arg473dup 1 inframe_insertion (see "Genomic_coordinates" sheet) 1 112 1 111 1 115 673 13928 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.99181086662394 0.990178261066581 0.993234431608945 0.00862068965517241 0.000218233149063064 0.0470955362266474 0.00892857142857142 0.000226026309206639 0.0487433047301257 0.00862068965517241 0.000218233149063064 0.0470955362266474 0.186444988822403 0.00467528967172521 1.06417213079994 0.0656225432286385 84 1319 False False 0.179959945732928 0.00451419530396094 1.02642940359066 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.99181086662394 0.990178261066581 0.993234431608945 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 214 4730 0 0 0.0170900343744659 0.999155048584706 0.997838014616212 0.999769732715123 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 33.6387430781262 1 83 572 False False 0 0 0 0 0 0 0 0 0 33.6387430781262 0 0 0.0170900343744659 0.999155048584706 0.997838014616212 0.999769732715123 363 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Arg481fs Rv1979c_p.Arg481fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Arg70fs Rv1979c_p.Arg70fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Arg7Lys Rv1979c_p.Arg7Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 118.033875066473 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 9 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c p.Arg7Ser Rv1979c_p.Arg7Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 23 0 23 0 28 674 14015 0 0 0.00545816471080279 0.998006124047568 0.99711957355846 0.998674687640767 0 0 0.123436118500263 0 0 0.148185128915224 0 0 0.123436118500263 0 0 3.62709074801108 0.624183632973403 135 1319 False False 0 0 2.93585632972 0 0 0.00545816471080279 0.998006124047568 0.99711957355846 0.998674687640767 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 489 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 60 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Arg88fs Rv1979c_p.Arg88fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.534232413570953 Inf 0.0457973771828497 55 1319 False False Inf 0.534232413570953 Inf 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 213 4734 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.56721266938512 Inf 0.0432497978981406 34 572 False False 0 0 0 0 0 0 0 Inf 0.56721266938512 Inf 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c p.Arg88His Rv1979c_p.Arg88His 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 1 2 673 14041 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999857580289112 0.999485626730555 0.999982751846902 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 10.4316493313521 0.176556008630772 200.333455094347 0.131204488725157 100 1319 False False 10.4316493313521 0.176556008630772 200.333455094347 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Arg88Leu Rv1979c_p.Arg88Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 118.033875066473 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Asn240fs Rv1979c_p.Asn240fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c p.Asp129fs Rv1979c_p.Asp129fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Asp249Glu Rv1979c_p.Asp249Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 1 8 2 11 672 14032 0.0029673590504451 0.000359563182310977 0.0106776554748576 0.999216691590116 0.998598878125098 0.999608912470572 0.153846153846153 0.0192066719825284 0.454471055676557 0.111111111111111 0.00280913674659921 0.482496514917337 0.0833333333333333 0.00210759323186022 0.384796165150944 2.61011904761904 0.0587363039706031 19.5122128049641 0.343942509658306 119 1319 False False 3.79653679653679 0.408055084222252 17.4493404048886 0.00148588410104011 3.7618620758983e-05 0.00825075228183891 0.999216691590116 0.998598878125098 0.999608912470572 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 1 4 2 7 212 4727 0.00934579439252336 0.00113382977970066 0.0333506066446319 0.998521335023236 0.996955773035796 0.999405299839924 0.222222222222222 0.0281449734778982 0.600093573716312 0.2 0.00505076337946806 0.716417936118089 0.125 0.0031597235312519 0.526509670875206 5.57429245283018 0.112663591465578 56.6043237201655 0.197707270536467 57 572 False False 0 0 0 0 0 0 0 6.37061994609164 0.641478339003349 33.7094108293423 0.00469483568075117 0.000118855884362696 0.025878953838187 0.998521335023236 0.996955773035796 0.999405299839924 28 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Asp286Gly Rv1979c_p.Asp286Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 25 1089 649 12954 0.0370919881305637 0.0241451754880761 0.0542700894630137 0.922452467421491 0.917905172913421 0.926823790519755 0.0224416517055655 0.0145744586603248 0.0329509768291397 NA NA NA 0 0 0.00338167001490399 NA NA NA NA NA NA False True 0.458217134222176 0.292951585837706 0.686572584053525 0 0 0.00566782064295686 0.922452467421491 0.917905172913421 0.926823790519755 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 6 665 208 4069 0.02803738317757 0.0103572838244001 0.0600236488676055 0.859526827207435 0.849301220046041 0.869306761276659 0.00894187779433681 0.00328837900490184 0.0193604729015849 NA NA NA 0 0 0.00553182991601401 NA NA NA NA NA NA False True 1 1 1 0 0 1 0 0.176503759398496 0.0637707469917188 0.393141880521564 0 0 0.0175786579006307 0.859526827207435 0.849301220046041 0.869306761276659 3737 Not assoc w R 5) Not assoc w R No change yes 1 +Clofazimine Rv1979c p.Asp347Gly Rv1979c_p.Asp347Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Gln188fs Rv1979c_p.Gln188fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 672 14043 0.0029673590504451 0.000359563182310977 0.0106776554748576 1 0.999737349925893 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1101 1319 False False Inf 3.91661217545325 Inf 0 0 0.00547436470313033 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Gln385* Rv1979c_p.Gln385* 1 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1130 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 497 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 3 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Glu38Asp Rv1979c_p.Glu38Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 59 1 58 3 68 671 13975 0.00445103857566765 0.00091885344774779 0.0129522747681396 0.995157729829808 0.993865250977052 0.996237884218245 0.0422535211267605 0.00879991956156422 0.118555094452998 0.0169491525423728 0.000429023332723594 0.0908559328866492 0.0144927536231884 0.000366857444740834 0.0781235357401634 0.359088339585795 0.00892897751656627 2.08849651923716 0.524844148680134 133 1319 False False 0.918843692469536 0.184424569107151 2.81286880028589 0.00148809523809523 3.76745997948712e-05 0.00826298844437611 0.995157729829808 0.993865250977052 0.996237884218245 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 8 214 4726 0 0 0.0170900343744659 0.998310097169412 0.996672947522823 0.999270146456405 0 0 0.369416647552819 0 0 0.409616397225003 0 0 0.369416647552819 0 0 15.4173537499273 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 13.0211752369257 0 0 0.0170900343744659 0.998310097169412 0.996672947522823 0.999270146456405 186 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Glu38Lys Rv1979c_p.Glu38Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 674 14039 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 31.5916386345298 1 619 1319 False False 0 0 31.5916386345298 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 17 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Glu403Gly Rv1979c_p.Glu403Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 674 14037 0 0 0.00545816471080279 0.999572740867336 0.999070270474308 0.999843187804675 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 17.7219093583043 1 169 1319 False False 0 0 17.7219093583043 0 0 0.00545816471080279 0.999572740867336 0.999070270474308 0.999843187804675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Gly107Ala Rv1979c_p.Gly107Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Gly146Ser Rv1979c_p.Gly146Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Gly181_Ile185del Rv1979c_p.Gly181_Ile185del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1115 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c p.Gly214Ser Rv1979c_p.Gly214Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Gly216Asp Rv1979c_p.Gly216Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Gly334Glu Rv1979c_p.Gly334Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c p.Gly37Val Rv1979c_p.Gly37Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 118.033875066473 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 1 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.His12Tyr Rv1979c_p.His12Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c p.His404Tyr Rv1979c_p.His404Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.His98Tyr Rv1979c_p.His98Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 6 674 14037 0 0 0.00545816471080279 0.999572740867336 0.999070270474308 0.999843187804675 0 0 0.4592581264399 0 0 0.975 0 0 0.4592581264399 0 0 802.11986372305 1 169 1319 False False 0 0 17.7219093583043 0 0 0.00545816471080279 0.999572740867336 0.999070270474308 0.999843187804675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 6 214 4728 0 0 0.0170900343744659 0.998732572877059 0.997243401195562 0.999534739052189 0 0 0.4592581264399 0 0 0.975 0 0 0.4592581264399 0 0 850.389010488819 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 18.8747365567989 0 0 0.0170900343744659 0.998732572877059 0.997243401195562 0.999534739052189 1 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Ile100del Rv1979c_p.Ile100del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Ile104Thr Rv1979c_p.Ile104Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 24 0 24 0 25 674 14018 0 0 0.00545816471080279 0.9982197536139 0.997373119241404 0.99884759736706 0 0 0.137185171530712 0 0 0.142473597722525 0 0 0.137185171530712 0 0 3.46459948987421 0.625800448422562 136 1319 False False 0 0 3.3155826672856 0 0 0.00545816471080279 0.9982197536139 0.997373119241404 0.99884759736706 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 118.033875066473 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 128 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Ile226Thr Rv1979c_p.Ile226Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Ile238Thr Rv1979c_p.Ile238Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Ile256Thr Rv1979c_p.Ile256Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 674 14039 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 31.5916386345298 1 619 1319 False False 0 0 31.5916386345298 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 214 4731 0 0 0.0170900343744659 0.999366286438529 0.998149147855346 0.999869293957204 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 53.7295049630073 1 83 572 False False 0 0 0 0 0 0 0 0 0 53.7295049630073 0 0 0.0170900343744659 0.999366286438529 0.998149147855346 0.999869293957204 22 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Ile304_Ala381del Rv1979c_p.Ile304_Ala381del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c p.Ile394Thr Rv1979c_p.Ile394Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Ile394Val Rv1979c_p.Ile394Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1099 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 478 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 3 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Ile471Val Rv1979c_p.Ile471Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c p.Leu109Ser Rv1979c_p.Leu109Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1116 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 490 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Leu14Arg Rv1979c_p.Leu14Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 50.4845768710802 1 619 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c p.Leu174Phe Rv1979c_p.Leu174Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 1 7 2 7 672 14036 0.0029673590504451 0.000359563182310977 0.0106776554748576 0.999501531011892 0.998973234784508 0.999799566877855 0.222222222222222 0.0281449734778982 0.600093573716312 0.125 0.0031597235312519 0.526509670875206 0.125 0.0031597235312519 0.526509670875206 2.98384353741496 0.0661087905290045 23.27590695306 0.312423035120799 117 1319 False False 5.96768707482993 0.603623887944608 31.4191383669608 0.00148588410104011 3.7618620758983e-05 0.00825075228183891 0.999501531011892 0.998973234784508 0.999799566877855 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 214 4731 0 0 0.0170900343744659 0.999366286438529 0.998149147855346 0.999869293957204 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 53.7295049630073 1 83 572 False False 0 0 0 0 0 0 0 0 0 53.7295049630073 0 0 0.0170900343744659 0.999366286438529 0.998149147855346 0.999869293957204 19 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Leu229del Rv1979c_p.Leu229del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 674 14037 0 0 0.00545816471080279 0.999572740867336 0.999070270474308 0.999843187804675 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 17.7219093583043 1 169 1319 False False 0 0 17.7219093583043 0 0 0.00545816471080279 0.999572740867336 0.999070270474308 0.999843187804675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 214 4730 0 0 0.0170900343744659 0.999155048584706 0.997838014616212 0.999769732715123 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 33.6387430781262 1 83 572 False False 0 0 0 0 0 0 0 0 0 33.6387430781262 0 0 0.0170900343744659 0.999155048584706 0.997838014616212 0.999769732715123 3 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Leu229Ser Rv1979c_p.Leu229Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c p.Leu330Val Rv1979c_p.Leu330Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Leu336Arg Rv1979c_p.Leu336Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 2 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Leu419Val Rv1979c_p.Leu419Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c p.Lys13Gln Rv1979c_p.Lys13Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c p.Met1? Rv1979c_p.Met1? 1 start_lost (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 802.289132424172 1 619 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 479 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Met245Leu Rv1979c_p.Met245Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1100 1319 False False Inf 0.534232413570953 Inf 0 0 0.00546625270429624 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 213 4734 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 480 572 False False 0 0 0 0 0 0 0 Inf 0.56721266938512 Inf 0 0 0.0171695765109405 1 0.999221072542716 1 6 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c p.Met275Ile Rv1979c_p.Met275Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Met275Thr Rv1979c_p.Met275Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Met49Ile Rv1979c_p.Met49Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1120 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c p.Phe113fs Rv1979c_p.Phe113fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 4 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Phe122Leu Rv1979c_p.Phe122Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Phe144Cys Rv1979c_p.Phe144Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Phe144fs Rv1979c_p.Phe144fs 1 frameshift (see "Genomic_coordinates" sheet) 1 16 0 16 1 17 673 14026 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.998789432457452 0.998062469319839 0.999294646641111 0.0555555555555555 0.00140555616736942 0.272943599673368 0 0 0.205907214207822 0 0 0.195064322969093 0 0 5.41780111776024 1 169 1319 False False 1.22594178830521 0.0292914408017913 7.84699797474892 0 0 0.00546625270429624 0.998789432457452 0.998062469319839 0.999294646641111 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 0 10 214 4724 0 0 0.0170900343744659 0.997887621461766 0.996118702879007 0.998986582156994 0 0 0.30849710781876 0 0 0.30849710781876 0 0 0.30849710781876 0 0 9.91563904469691 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 9.91563904469691 0 0 0.0170900343744659 0.997887621461766 0.996118702879007 0.998986582156994 109 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Phe154fs Rv1979c_p.Phe154fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Phe154Val Rv1979c_p.Phe154Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c p.Phe172Ser Rv1979c_p.Phe172Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 50.4845768710802 1 619 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Phe218Ser Rv1979c_p.Phe218Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Phe300dup Rv1979c_p.Phe300dup 1 inframe_insertion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Phe300Leu Rv1979c_p.Phe300Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 0 670 14043 0.0059347181008902 0.00161930788766713 0.0151250012595154 1 0.999737349925893 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 1102 1319 False False Inf 13.7930869748905 Inf 0 0 0.00549066114558213 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 0 210 4734 0.0186915887850467 0.00511573452207981 0.0471638210086244 1 0.999221072542716 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 481 572 False False 0 0 0 0 0 0 0 Inf 14.743484119673 Inf 0 0 0.0174127082678636 1 0.999221072542716 1 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c p.Phe300Val Rv1979c_p.Phe300Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Phe386Val Rv1979c_p.Phe386Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1121 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Phe412Cys Rv1979c_p.Phe412Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1117 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c p.Phe447Val Rv1979c_p.Phe447Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Pro123Ser Rv1979c_p.Pro123Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c p.Pro36Ser Rv1979c_p.Pro36Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Pro478Gln Rv1979c_p.Pro478Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 14 0 14 0 14 674 14029 0 0 0.00545816471080279 0.999003062023784 0.998327872643959 0.99945486094574 0 0 0.231635761650116 0 0 0.231635761650116 0 0 0.231635761650116 0 0 6.29097464007981 1 619 1319 False False 0 0 6.29097464007981 0 0 0.00545816471080279 0.999003062023784 0.998327872643959 0.99945486094574 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 7 214 4727 0 0 0.0170900343744659 0.998521335023236 0.996955773035796 0.999405299839924 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 15.4206152522212 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 15.4206152522212 0 0 0.0170900343744659 0.998521335023236 0.996955773035796 0.999405299839924 19 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Pro4Ala Rv1979c_p.Pro4Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Ser175Leu Rv1979c_p.Ser175Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 674 14039 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 50.4809680276667 1 619 1319 False False 0 0 31.5916386345298 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 214 4730 0 0 0.0170900343744659 0.999155048584706 0.997838014616212 0.999769732715123 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 53.7180800648943 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 33.6387430781262 0 0 0.0170900343744659 0.999155048584706 0.997838014616212 0.999769732715123 19 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Ser206Leu Rv1979c_p.Ser206Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Ser219Ala Rv1979c_p.Ser219Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Ser219Trp Rv1979c_p.Ser219Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1123 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 493 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c p.Ser237Leu Rv1979c_p.Ser237Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Ser262Leu Rv1979c_p.Ser262Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 674 14039 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 31.5916386345298 1 619 1319 False False 0 0 31.5916386345298 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Ser352fs Rv1979c_p.Ser352fs 1 frameshift (see "Genomic_coordinates" sheet) 1 11 0 11 0 11 674 14032 0 0 0.00545816471080279 0.999216691590116 0.998598878125098 0.999608912470572 0 0 0.284914152918154 0 0 0.284914152918154 0 0 0.284914152918154 0 0 8.31593780715244 1 619 1319 False False 0 0 8.31593780715244 0 0 0.00545816471080279 0.999216691590116 0.998598878125098 0.999608912470572 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 214 4730 0 0 0.0170900343744659 0.999155048584706 0.997838014616212 0.999769732715123 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 33.6387430781262 1 83 572 False False 0 0 0 0 0 0 0 0 0 33.6387430781262 0 0 0.0170900343744659 0.999155048584706 0.997838014616212 0.999769732715123 75 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Ser358Leu Rv1979c_p.Ser358Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Ser358* Rv1979c_p.Ser358* 1 stop_gained (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Ser399Phe Rv1979c_p.Ser399Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Thr270Ala Rv1979c_p.Thr270Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 50 3 47 3 51 671 13992 0.00445103857566765 0.00091885344774779 0.0129522747681396 0.996368297372356 0.995227712757948 0.997294799490936 0.0555555555555555 0.0116067743799413 0.153885033791633 0.06 0.012548587835334 0.165481946603772 0.0555555555555555 0.0116067743799413 0.153885033791633 1.33100802232298 0.264312234190088 4.15178598901822 0.49883786432301 131 1319 False False 1.22661523625843 0.244236543506453 3.80809572909601 0.00445103857566765 0.00091885344774779 0.0129522747681396 0.996368297372356 0.995227712757948 0.997294799490936 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 29 0 29 0 31 214 4703 0 0 0.0170900343744659 0.993451626531474 0.990717879050874 0.995546488337283 0 0 0.11218874692237 0 0 0.119444869069502 0 0 0.11218874692237 0 0 3.00605109637566 0.635536562413222 61 572 False False 0 0 0 0 0 0 0 0 0 2.80061071595361 0 0 0.0170900343744659 0.993451626531474 0.990717879050874 0.995546488337283 60 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Thr270Ile Rv1979c_p.Thr270Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 6 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c p.Thr356Lys Rv1979c_p.Thr356Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 674 14039 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 111.084736596165 1 619 1319 False False 0 0 31.5916386345298 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 482 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 35 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Thr413Asn Rv1979c_p.Thr413Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Thr67Ala Rv1979c_p.Thr67Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Thr82fs Rv1979c_p.Thr82fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 673 14042 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999928790144556 0.999603308654684 0.999998197124178 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1105 1319 False False 20.8647845468053 0.265412371331172 1613.44310281692 0 0 0.00546625270429624 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c p.Thr83Ala Rv1979c_p.Thr83Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Trp106* Rv1979c_p.Trp106* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Trp197* Rv1979c_p.Trp197* 1 stop_gained (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 673 14042 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999928790144556 0.999603308654684 0.999998197124178 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1134 1319 False False 20.8647845468053 0.265412371331172 1613.44310281692 0 0 0.00546625270429624 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 213 4734 0.00467289719626168 0.000118300515887328 0.0257593138532706 1 0.999221072542716 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 499 572 False False 0 0 0 0 0 0 0 Inf 0.56721266938512 Inf 0 0 0.0171695765109405 1 0.999221072542716 1 1 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c p.Tyr230Cys Rv1979c_p.Tyr230Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c p.Tyr230* Rv1979c_p.Tyr230* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c p.Tyr434Cys Rv1979c_p.Tyr434Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 5 674 14038 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 0 0 0.521823750104981 0 0 0.841886116991581 0 0 0.521823750104981 0 0 111.076905027906 1 169 1319 False False 0 0 22.7684048554448 0 0 0.00545816471080279 0.99964395072278 0.999169297020829 0.999884381985141 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Tyr51Asn Rv1979c_p.Tyr51Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 168 9 159 11 194 663 13849 0.016320474777448 0.00817455131696952 0.0290138543646141 0.986185288043865 0.984115196686719 0.988050139446632 0.0536585365853658 0.0270871858872691 0.0939800816511226 0.0535714285714285 0.0247857901821293 0.0992570939658056 0.0443349753694581 0.0204703039339371 0.0824906920946102 1.18236147869888 0.528478037822443 2.31559867607728 0.576243117774756 134 1319 False False 1.18439302763135 0.578643657507391 2.18088008328645 0.0133928571428571 0.00614186429695565 0.0252710203270489 0.986185288043865 0.984115196686719 0.988050139446632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 7 214 4727 0 0 0.0170900343744659 0.998521335023236 0.996955773035796 0.999405299839924 0 0 0.409616397225003 0 0 0.521823750104981 0 0 0.409616397225003 0 0 24.2401398701131 1 83 572 False False 0 0 0 0 0 0 0 0 0 15.4206152522212 0 0 0.0170900343744659 0.998521335023236 0.996955773035796 0.999405299839924 191 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Tyr71Cys Rv1979c_p.Tyr71Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.534232413570953 Inf 0.0457973771828497 55 1319 False False Inf 0.534232413570953 Inf 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c p.Tyr79Cys Rv1979c_p.Tyr79Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Tyr81Asp Rv1979c_p.Tyr81Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Val108fs Rv1979c_p.Val108fs 1 frameshift (see "Genomic_coordinates" sheet) 1 12 1 11 1 13 673 14030 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999074271879228 0.998417496974718 0.999506999611345 0.0714285714285714 0.00180678065912538 0.338684489931821 0.0833333333333333 0.00210759323186022 0.384796165150944 0.0714285714285714 0.00180678065912538 0.338684489931821 1.89517763069026 0.0439651472586206 13.0706855561097 0.430413455745509 130 1319 False False 1.60361184135329 0.0376787358643995 10.7089545330159 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999074271879228 0.998417496974718 0.999506999611345 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 5 214 4729 0 0 0.0170900343744659 0.998943810730883 0.997536942130593 0.999656972101492 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 53.7066553001796 1 83 572 False False 0 0 0 0 0 0 0 0 0 24.2508634033673 0 0 0.0170900343744659 0.998943810730883 0.997536942130593 0.999656972101492 15 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c p.Val114fs Rv1979c_p.Val114fs 1 frameshift (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 50.4845768710802 1 619 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 118.033875066473 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 10 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Val114Gly Rv1979c_p.Val114Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Val120Leu Rv1979c_p.Val120Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c p.Val136Leu Rv1979c_p.Val136Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c p.Val190Ala Rv1979c_p.Val190Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 2 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Val210Phe Rv1979c_p.Val210Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Val273Ala Rv1979c_p.Val273Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 674 14039 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 31.5916386345298 1 619 1319 False False 0 0 31.5916386345298 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Val2Ala Rv1979c_p.Val2Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 674 14039 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 31.5916386345298 1 619 1319 False False 0 0 31.5916386345298 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Val305Asp Rv1979c_p.Val305Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Val384Ile Rv1979c_p.Val384Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1103 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Val402Gly Rv1979c_p.Val402Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 50.4845768710802 1 619 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 214 4731 0 0 0.0170900343744659 0.999366286438529 0.998149147855346 0.999869293957204 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 53.7295049630073 1 83 572 False False 0 0 0 0 0 0 0 0 0 53.7295049630073 0 0 0.0170900343744659 0.999366286438529 0.998149147855346 0.999869293957204 5 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Val416Met Rv1979c_p.Val416Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Val423Ala Rv1979c_p.Val423Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 674 14037 0 0 0.00545816471080279 0.999572740867336 0.999070270474308 0.999843187804675 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 17.7219093583043 1 169 1319 False False 0 0 17.7219093583043 0 0 0.00545816471080279 0.999572740867336 0.999070270474308 0.999843187804675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 23 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Val423Leu Rv1979c_p.Val423Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1107 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Val426Ile Rv1979c_p.Val426Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 85 3 82 3 86 671 13957 0.00445103857566765 0.00091885344774779 0.0129522747681396 0.993875952431816 0.992442298606481 0.995098719509231 0.0337078651685393 0.00700605683367105 0.0953615656063197 0.0352941176470588 0.00733848695484827 0.0996963709068812 0.0337078651685393 0.00700605683367105 0.0953615656063197 0.760986514485115 0.153348350190842 2.31319512039838 1 619 1319 False False 0.725591792881156 0.146400617720189 2.20205049540858 0.00445103857566765 0.00091885344774779 0.0129522747681396 0.993875952431816 0.992442298606481 0.995098719509231 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 214 4730 0 0 0.0170900343744659 0.999155048584706 0.997838014616212 0.999769732715123 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 33.6387430781262 1 83 572 False False 0 0 0 0 0 0 0 0 0 33.6387430781262 0 0 0.0170900343744659 0.999155048584706 0.997838014616212 0.999769732715123 139 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Val458Ala Rv1979c_p.Val458Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c p.Val459Ile Rv1979c_p.Val459Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Val52Gly Rv1979c_p.Val52Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 17 0 17 0 19 674 14024 0 0 0.00545816471080279 0.998647012746564 0.997887945605923 0.999185222909761 0 0 0.176466911806965 0 0 0.195064322969093 0 0 0.176466911806965 0 0 5.05510583032712 1 169 1319 False False 0 0 4.46995253778459 0 0 0.00545816471080279 0.998647012746564 0.997887945605923 0.999185222909761 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 16 0 16 0 18 214 4716 0 0 0.0170900343744659 0.996197718631178 0.993997388291213 0.997745017823554 0 0 0.185301968137852 0 0 0.205907214207822 0 0 0.185301968137852 0 0 5.75940255529189 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 5.0524201521135 0 0 0.0170900343744659 0.996197718631178 0.993997388291213 0.997745017823554 15 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Val52Leu Rv1979c_p.Val52Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance No change no 1 +Clofazimine Rv1979c p.Val96fs Rv1979c_p.Val96fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1112 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 485 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 12 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv1979c p.Val96Ile Rv1979c_p.Val96Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 673 14042 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999928790144556 0.999603308654684 0.999998197124178 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 20.8647845468053 0.265412371331172 1613.44310281692 0.0895003241642821 90 1319 False False 20.8647845468053 0.265412371331172 1613.44310281692 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 c.147C>T Rv2983_c.147C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv2983 c.15G>C Rv2983_c.15G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv2983 c.183T>C Rv2983_c.183T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv2983 c.186C>T Rv2983_c.186C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv2983 c.189C>A Rv2983_c.189C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv2983 c.-1C>A Rv2983_c.-1C>A 2 upstream_gene_variant 3339117 1 0 0 0 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1245 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 c.-20G>A Rv2983_c.-20G>A 2 upstream_gene_variant 3339098 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1240 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 542 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 c.216G>A Rv2983_c.216G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 11 672 14032 0.0029673590504451 0.000359563182310977 0.0106776554748576 0.999216691590116 0.998598878125098 0.999608912470572 0.153846153846153 0.0192066719825284 0.454471055676557 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.79653679653679 0.408055084222252 17.4493404048886 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 213 4733 0.00467289719626168 0.000118300515887328 0.0257593138532706 0.999788762146176 0.998823626139438 0.999994651934878 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 22.2206572769953 0.281762968762878 1716.65162034476 NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv2983 c.240G>A Rv2983_c.240G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv2983 c.285C>T Rv2983_c.285C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv2983 c.300A>G Rv2983_c.300A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 65 673 13978 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.99537135939614 0.994104169195298 0.996425950607552 0.0151515151515151 0.000383529584995338 0.0815523210948241 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.319533660989827 0.00796019748007776 1.85053633749138 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 16 214 4718 0 0 0.0170900343744659 0.996620194338825 0.994517194987006 0.998066952912566 0 0 0.205907214207822 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 5.76184539559342 NA NA NA NA NA NA 907 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv2983 c.303C>T Rv2983_c.303C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv2983 c.-34G>C Rv2983_c.-34G>C 2 upstream_gene_variant 3339084 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 4 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 c.354G>A Rv2983_c.354G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 50.4845768710802 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 214 4731 0 0 0.0170900343744659 0.999366286438529 0.998149147855346 0.999869293957204 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 53.7295049630073 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv2983 c.369G>A Rv2983_c.369G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv2983 c.-37A>G Rv2983_c.-37A>G 2 upstream_gene_variant 3339081 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 c.399C>A Rv2983_c.399C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 10 673 14033 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.99928790144556 0.998690816610614 0.99965846992849 0.0909090909090909 0.00229897221381426 0.412779916988382 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.08514115898959 0.0479768321599935 14.6913291611026 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv2983 c.429G>C Rv2983_c.429G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv2983 c.444C>G Rv2983_c.444C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv2983 c.444C>T Rv2983_c.444C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv2983 c.459G>C Rv2983_c.459G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv2983 c.-4C>T Rv2983_c.-4C>T 2 upstream_gene_variant 3339114 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 c.504G>A Rv2983_c.504G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 673 14042 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999928790144556 0.999603308654684 0.999998197124178 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 20.8647845468053 0.265412371331172 1613.44310281692 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv2983 c.-50G>C Rv2983_c.-50G>C 2 upstream_gene_variant 3339068 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 c.513C>T Rv2983_c.513C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 50.4845768710802 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 36 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv2983 c.561C>T Rv2983_c.561C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv2983 c.564T>C Rv2983_c.564T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv2983 c.573C>T Rv2983_c.573C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 802.401977721179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 851.276172494021 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv2983 c.624G>A Rv2983_c.624G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 50.4845768710802 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 118.033875066473 NA NA NA NA NA NA 22 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv2983 c.636A>G Rv2983_c.636A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.100399686832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 118.033875066473 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Clofazimine Rv2983 LoF Rv2983_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 673 14042 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999928790144556 0.999603308654684 0.999998197124178 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 803.579283928634 1 619 1319 False False 20.8647845468053 0.265412371331172 1613.44310281692 0 0 0.00546625270429624 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 p.Ala107Asp Rv2983_p.Ala107Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 p.Ala107Val Rv2983_p.Ala107Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1233 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 540 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 23 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 p.Ala119Val Rv2983_p.Ala119Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 p.Ala157Glu Rv2983_p.Ala157Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 p.Ala20Val Rv2983_p.Ala20Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 50.4845768710802 1 619 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 p.Ala210Ser Rv2983_p.Ala210Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 p.Ala210Val Rv2983_p.Ala210Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.534232413570953 Inf 0.0457973771828497 55 1319 False False Inf 0.534232413570953 Inf 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 p.Ala21Thr Rv2983_p.Ala21Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 674 14039 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 31.5916386345298 1 619 1319 False False 0 0 31.5916386345298 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 p.Ala32Thr Rv2983_p.Ala32Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 674 14039 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 31.5916386345298 1 619 1319 False False 0 0 31.5916386345298 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 p.Ala50Thr Rv2983_p.Ala50Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 p.Ala68Thr Rv2983_p.Ala68Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 p.Ala71Glu Rv2983_p.Ala71Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 p.Ala72Thr Rv2983_p.Ala72Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1243 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 545 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 p.Arg101Cys Rv2983_p.Arg101Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 p.Arg101His Rv2983_p.Arg101His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 p.Arg101Leu Rv2983_p.Arg101Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 p.Arg169Gln Rv2983_p.Arg169Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 674 14040 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 50.4845768710802 1 619 1319 False False 0 0 50.4845768710802 0 0 0.00545816471080279 0.999786370433668 0.999375811939756 0.999955942280632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 p.Arg171His Rv2983_p.Arg171His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1242 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 544 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 p.Arg172Ser Rv2983_p.Arg172Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 2 673 14041 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.999857580289112 0.999485626730555 0.999982751846902 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1241 1319 False False 10.4316493313521 0.176556008630772 200.333455094347 0 0 0.00546625270429624 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 2 213 4732 0.00467289719626168 0.000118300515887328 0.0257593138532706 0.999577524292353 0.998474714407054 0.999948832136202 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 543 572 False False 0 0 0 0 0 0 0 11.1079812206572 0.187407717913085 213.598932938617 0 0 0.0171695765109405 0.999577524292353 0.998474714407054 0.999948832136202 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 p.Arg199Cys Rv2983_p.Arg199Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 p.Arg209Gln Rv2983_p.Arg209Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 p.Arg57Leu Rv2983_p.Arg57Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 1 5 1 5 673 14038 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.99964395072278 0.999169297020829 0.999884381985141 0.166666666666666 0.00421074451448947 0.641234578997674 0.166666666666666 0.00421074451448947 0.641234578997674 0.166666666666666 0.00421074451448947 0.641234578997674 4.17176820208023 0.0880732176054642 37.3482568099296 0.245216521289771 115.5 1319 False False 4.17176820208023 0.0880732176054642 37.3482568099296 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 0.99964395072278 0.999169297020829 0.999884381985141 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 18 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 p.Asn37Asp Rv2983_p.Asn37Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 p.Asp78Asn Rv2983_p.Asp78Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1235 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 p.Asp87Tyr Rv2983_p.Asp87Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 p.Asp88Asn Rv2983_p.Asp88Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 1 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 p.Asp90Asn Rv2983_p.Asp90Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 12 2 10 2 10 672 14033 0.0029673590504451 0.000359563182310977 0.0106776554748576 0.99928790144556 0.998690816610614 0.99965846992849 0.166666666666666 0.0208625254600923 0.484137748685967 0.166666666666666 0.0208625254600923 0.484137748685967 0.166666666666666 0.0208625254600923 0.484137748685967 4.17648809523809 0.444019440247049 19.6502074446671 0.102035246129962 95 1319 False False 4.17648809523809 0.444019440247049 19.6502074446671 0.0029673590504451 0.000359563182310977 0.0106776554748576 0.99928790144556 0.998690816610614 0.99965846992849 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 214 4730 0 0 0.0170900343744659 0.999155048584706 0.997838014616212 0.999769732715123 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 33.6387430781262 1 83 572 False False 0 0 0 0 0 0 0 0 0 33.6387430781262 0 0 0.0170900343744659 0.999155048584706 0.997838014616212 0.999769732715123 43 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 p.Gln121His Rv2983_p.Gln121His 2 missense_variant (see "Genomic_coordinates" sheet) 1 11 0 11 0 11 674 14032 0 0 0.00545816471080279 0.999216691590116 0.998598878125098 0.999608912470572 0 0 0.284914152918154 0 0 0.284914152918154 0 0 0.284914152918154 0 0 8.31593780715244 1 619 1319 False False 0 0 8.31593780715244 0 0 0.00545816471080279 0.999216691590116 0.998598878125098 0.999608912470572 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 p.Gln123Arg Rv2983_p.Gln123Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 214 4732 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 118.033875066473 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 118.033875066473 0 0 0.0170900343744659 0.999577524292353 0.998474714407054 0.999948832136202 1 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 p.Glu105Asp Rv2983_p.Glu105Asp 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1234 1319 False False Inf 0.534232413570953 Inf 0 0 0.00546625270429624 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 p.Gly145Arg Rv2983_p.Gly145Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 4 674 14039 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 802.232709624548 1 619 1319 False False 0 0 31.5916386345298 0 0 0.00545816471080279 0.999715160578224 0.999270860010958 0.999922385565456 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 26 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 p.Gly155Ser Rv2983_p.Gly155Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 6 674 14037 0 0 0.00545816471080279 0.999572740867336 0.999070270474308 0.999843187804675 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 22.7667854541547 1 169 1319 False False 0 0 17.7219093583043 0 0 0.00545816471080279 0.999572740867336 0.999070270474308 0.999843187804675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 6 214 4728 0 0 0.0170900343744659 0.998732572877059 0.997243401195562 0.999534739052189 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 24.2455018638228 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 18.8747365567989 0 0 0.0170900343744659 0.998732572877059 0.997243401195562 0.999534739052189 3 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 p.Gly3Ser Rv2983_p.Gly3Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 p.Gly74Arg Rv2983_p.Gly74Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.534232413570953 Inf 0.0457973771828497 55 1319 False False Inf 0.534232413570953 Inf 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 p.Gly76Ser Rv2983_p.Gly76Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1239 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 p.Gly8Asp Rv2983_p.Gly8Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 p.Ile110Thr Rv2983_p.Ile110Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 p.Ile110Val Rv2983_p.Ile110Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1236 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 p.Ile13Leu Rv2983_p.Ile13Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 6 674 14037 0 0 0.00545816471080279 0.999572740867336 0.999070270474308 0.999843187804675 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1246 1319 False False 0 0 17.7219093583043 0 0 0.00545816471080279 0.999572740867336 0.999070270474308 0.999843187804675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 10 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 p.Ile59Leu Rv2983_p.Ile59Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 9 0 9 0 9 674 14034 0 0 0.00545816471080279 0.999359111301004 0.998783743811125 0.999706904333134 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.336267116879942 0 0 10.5701597897411 1 619 1319 False False 0 0 10.5701597897411 0 0 0.00545816471080279 0.999359111301004 0.998783743811125 0.999706904333134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 p.Leu125Ile Rv2983_p.Leu125Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 111.100399686832 1 619 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 27 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 p.Leu144Val Rv2983_p.Leu144Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 p.Pro28del Rv2983_p.Pro28del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.534232413570953 Inf 0.0457973771828497 55 1319 False False Inf 0.534232413570953 Inf 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 p.Pro91Ser Rv2983_p.Pro91Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 674 14041 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1237 1319 False False 0 0 111.100399686832 0 0 0.00545816471080279 0.999857580289112 0.999485626730555 0.999982751846902 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 p.Ser138Thr Rv2983_p.Ser138Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 p.Ter215Argext*? Rv2983_p.Ter215Argext*? 2 stop_lost (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 p.Thr146Ala Rv2983_p.Thr146Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 p.Thr146Ser Rv2983_p.Thr146Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1238 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 541 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 p.Thr148fs Rv2983_p.Thr148fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 214 4733 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 0 0 0.975 0 0 0.975 0 0 0.975 0 0 851.276172494021 1 279.5 572 False False 0 0 0 0 0 0 0 0 0 851.276172494021 0 0 0.0170900343744659 0.999788762146176 0.998823626139438 0.999994651934878 NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 p.Thr179Pro Rv2983_p.Thr179Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 p.Thr191fs Rv2983_p.Thr191fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 673 14043 0.00148367952522255 3.75628078298738e-05 0.00823855230513148 1 0.999737349925893 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1244 1319 False False Inf 0.534232413570953 Inf 0 0 0.00546625270429624 1 0.999737349925893 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Clofazimine Rv2983 p.Val61Ile Rv2983_p.Val61Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 674 14042 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 0 0 0.975 0 0 0.975 0 0 0.975 0 0 802.401977721179 1 619 1319 False False 0 0 802.401977721179 0 0 0.00545816471080279 0.999928790144556 0.999603308654684 0.999998197124178 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid ddn c.-10G>A ddn_c.-10G>A 1 upstream_gene_variant 3986834 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid ddn c.144G>T ddn_c.144G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.334370311011 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 74 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ddn c.150C>T ddn_c.150C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ddn c.15G>C ddn_c.15G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ddn c.162C>T ddn_c.162C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.334370311011 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ddn c.168C>T ddn_c.168C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 13 248 11381 0.00401606425702811 0.000101672774685082 0.0221717421523238 0.998859048622081 0.998049728679073 0.999392356006787 0.0714285714285714 0.00180678065912538 0.338684489931821 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.53008684863523 0.082735670286697 23.6823731093794 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 59 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ddn c.189G>A ddn_c.189G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.334370311011 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 363.375224416517 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ddn c.-24C>A ddn_c.-24C>A 1 upstream_gene_variant 3986820 1 3 0 3 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 111.334370311011 1 245.5 609 False False 0 0 111.334370311011 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 13 3) Uncertain significance No change no 1 +Delamanid ddn c.252G>A ddn_c.252G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 4 247 11390 0.00803212851405622 0.00097421250436962 0.028711995092973 0.999648938037563 0.999101388115099 0.99990433941184 0.333333333333333 0.0432718682927417 0.777221904496487 NA NA NA NA NA NA NA NA NA NA NA NA False False 23.0566801619433 2.07390948783324 161.965699659111 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 38 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ddn c.-26G>C ddn_c.-26G>C 1 upstream_gene_variant 3986818 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid ddn c.-26G>T ddn_c.-26G>T 1 upstream_gene_variant 3986818 1 5 0 5 0 6 249 11388 0 0 0.0147055780339792 0.999473407056345 0.998854183895649 0.999806725936475 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 50.1299598353901 1 245.5 609 False False 0 0 39.0576580619631 0 0 0.0147055780339792 0.999473407056345 0.998854183895649 0.999806725936475 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 0 0 0.975 0 0 0.975 0 0 363.375224416517 1 34 83 False False 0 0 0 0 0 0 0 0 0 363.375224416517 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 10 3) Uncertain significance No change no 1 +Delamanid ddn c.273C>T ddn_c.273C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 244.222407132781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ddn c.27G>A ddn_c.27G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ddn c.294T>C ddn_c.294T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ddn c.300A>G ddn_c.300A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ddn c.318G>C ddn_c.318G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ddn c.-32T>G ddn_c.-32T>G 1 upstream_gene_variant 3986812 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 573 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Delamanid ddn c.378G>A ddn_c.378G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ddn c.384G>A ddn_c.384G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 244.222407132781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ddn c.390C>T ddn_c.390C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 13 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ddn c.426C>T ddn_c.426C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 244.222407132781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ddn c.-4C>T ddn_c.-4C>T 1 upstream_gene_variant 3986840 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid ddn c.-6A>C ddn_c.-6A>C 1 upstream_gene_variant 3986838 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance No change no 1 +Delamanid ddn c.6G>T ddn_c.6G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 249 11390 0 0 0.0147055780339792 0.999648938037563 0.999101388115099 0.99990433941184 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 69.5552063788676 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ddn LoF ddn_LoF 1 LoF (see "Genomic_coordinates" sheet) 1 13 9 4 19 5 230 11389 0.0763052208835341 0.046564051999502 0.116596656793346 0.999561172546954 0.998976222751812 0.99985749905819 0.791666666666666 0.578487156362747 0.928681382801945 0.692307692307692 0.385738338249294 0.909079605427903 0.642857142857142 0.351380110615991 0.87240157014084 111.414130434782 30.7347543550568 494.582058930254 3.74044794411325e-13 2 609 True False 188.166086956521 66.9834182598938 639.38053295771 0.0376569037656903 0.0173612444834577 0.0702785581225293 0.999561172546954 0.998976222751812 0.99985749905819 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance 1 4 3 1 6 2 48 504 0.111111111111111 0.041883763577854 0.226313162629965 0.996047430830039 0.985795485070057 0.999520966589986 0.75 0.349144205587175 0.968145973750055 0.75 0.194120449683243 0.99369053679029 0.6 0.146632799634673 0.947255049473683 31.5 2.43916048227281 1637.97686993258 0.0027332800038001 1 83 False False 0 0 0 0 0 0 0 31.5 5.36714064479795 320.22225586299 0.0588235294117647 0.01229908825524 0.16242221807205 0.996047430830039 0.985795485070057 0.999520966589986 NA Marker of R Evidence from ALL dataset only 2) Assoc w R - Interim Confers DLM-PMD cross-resistance New AwRI yes ALL only R 5 +Delamanid ddn p.Ala111fs ddn_p.Ala111fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 579 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 78 83 False False 0 0 0 0 0 0 0 0 0 363.375224416517 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim New AwRI no 5 +Delamanid ddn p.Ala120Ser ddn_p.Ala120Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 574 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid ddn p.Arg23Trp ddn_p.Arg23Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 249 11388 0 0 0.0147055780339792 0.999473407056345 0.998854183895649 0.999806725936475 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 39.0576580619631 1 47 609 False False 0 0 39.0576580619631 0 0 0.0147055780339792 0.999473407056345 0.998854183895649 0.999806725936475 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 3) Uncertain significance No change no 1 +Delamanid ddn p.Arg30Ser ddn_p.Arg30Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 249 11389 0 0 0.0147055780339792 0.999561172546954 0.998976222751812 0.99985749905819 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 50.1343664673437 1 245.5 609 False False 0 0 50.1343664673437 0 0 0.0147055780339792 0.999561172546954 0.998976222751812 0.99985749905819 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 54 3) Uncertain significance No change no 1 +Delamanid ddn p.Arg31fs ddn_p.Arg31fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 247 11394 0.00803212851405622 0.00097421250436962 0.028711995092973 1 0.999676296088332 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 8.61397407191288 Inf 0.000455573585602705 7 609 True False Inf 8.61397407191288 Inf 0.00803212851405622 0.00097421250436962 0.028711995092973 1 0.999676296088332 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim UP from Uncertain to AwRI AwRI by relaxed thresholds (not endorsed) no O 4 +Delamanid ddn p.Arg72Gln ddn_p.Arg72Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 571 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Delamanid ddn p.Arg72Gly ddn_p.Arg72Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid ddn p.Arg72Trp ddn_p.Arg72Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 11 0 11 0 12 249 11382 0 0 0.0147055780339792 0.99894681411269 0.998161019670976 0.999455688821616 0 0 0.264648469397051 0 0 0.284914152918154 0 0 0.264648469397051 0 0 18.3225050866207 1 245.5 609 False False 0 0 16.5505207754502 0 0 0.0147055780339792 0.99894681411269 0.998161019670976 0.999455688821616 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 0 0 0.975 0 0 0.975 0 0 363.375224416517 1 34 83 False False 0 0 0 0 0 0 0 0 0 363.375224416517 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 89 3) Uncertain significance No change no 1 +Delamanid ddn p.Arg7Leu ddn_p.Arg7Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid ddn p.Asp108Asn ddn_p.Asp108Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 570 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid ddn p.Asp108fs ddn_p.Asp108fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 2 0 3 0 246 11394 0.0120481927710843 0.00249155218688723 0.0348042232340379 1 0.999676296088332 1 1 0.292401773821286 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 8.64890210749838 Inf 0.00045199200186074 5 609 True False Inf 19.0139189471509 Inf 0.00806451612903225 0.000978146808103289 0.028826549750623 1 0.999676296088332 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 3 0 51 506 0.0555555555555555 0.0116067743799413 0.153885033791633 1 0.992736233998274 1 1 0.292401773821286 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 1.81142640498628 Inf 0.00883554221888807 2 83 False False 0 0 0 0 0 0 0 Inf 3.96164470012735 Inf 0.0377358490566037 0.00460310927431491 0.129758381663062 1 0.992736233998274 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim New AwRI AwRI by relaxed thresholds (not endorsed) no O 5 +Delamanid ddn p.Asp113Asn ddn_p.Asp113Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 580 609 False False 0 0 111.334370311011 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 76 3) Uncertain significance New Uncertain no 0 +Delamanid ddn p.Asp15Asn ddn_p.Asp15Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 0 0 0.975 0 0 0.975 0 0 363.375224416517 1 34 83 False False 0 0 0 0 0 0 0 0 0 363.375224416517 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 1 3) Uncertain significance New Uncertain no 0 +Delamanid ddn p.Asp15Glu ddn_p.Asp15Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid ddn p.Glu105Lys ddn_p.Glu105Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 0 0 0.975 0 0 0.975 0 0 363.375224416517 1 34 83 False False 0 0 0 0 0 0 0 0 0 363.375224416517 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 1 3) Uncertain significance New Uncertain no 0 +Delamanid ddn p.Glu150Asp ddn_p.Glu150Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 244.222407132781 1 245.5 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 54 504 0 0 0.0660315142444217 0.996047430830039 0.985795485070057 0.999520966589986 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 50.236220806896 1 34 83 False False 0 0 0 0 0 0 0 0 0 50.236220806896 0 0 0.0660315142444217 0.996047430830039 0.985795485070057 0.999520966589986 1 3) Uncertain significance New Uncertain no 0 +Delamanid ddn p.Glu83Ala ddn_p.Glu83Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 244.222407132781 1 245.5 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 54 504 0 0 0.0660315142444217 0.996047430830039 0.985795485070057 0.999520966589986 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 50.236220806896 1 34 83 False False 0 0 0 0 0 0 0 0 0 50.236220806896 0 0 0.0660315142444217 0.996047430830039 0.985795485070057 0.999520966589986 2 3) Uncertain significance New Uncertain no 0 +Delamanid ddn p.Glu83Asp ddn_p.Glu83Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 12 0 12 0 13 249 11381 0 0 0.0147055780339792 0.998859048622081 0.998049728679073 0.999392356006787 0 0 0.24705263800047 0 0 0.264648469397051 0 0 0.24705263800047 0 0 16.5490664353768 1 245.5 609 False False 0 0 15.0886691165784 0 0 0.0147055780339792 0.998859048622081 0.998049728679073 0.999392356006787 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 6 54 500 0 0 0.0660315142444217 0.988142292490118 0.97437044953677 0.995636339212082 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 10.3460995307036 1 34 83 False False 0 0 0 0 0 0 0 0 0 8.06959148434815 0 0 0.0660315142444217 0.988142292490118 0.97437044953677 0.995636339212082 78 3) Uncertain significance No change no 1 +Delamanid ddn p.Gly34Arg ddn_p.Gly34Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 1 4 248 11390 0.00401606425702811 0.000101672774685082 0.0221717421523238 0.999648938037563 0.999101388115099 0.99990433941184 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 69.8364937694233 1 245.5 609 False False 11.4818548387096 0.232219387186332 116.868013030161 0 0 0.0147644348125545 0.999648938037563 0.999101388115099 0.99990433941184 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 18 3) Uncertain significance No change no 1 +Delamanid ddn p.Gly34Glu ddn_p.Gly34Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 249 11389 0 0 0.0147055780339792 0.999561172546954 0.998976222751812 0.99985749905819 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 50.1343664673437 1 245.5 609 False False 0 0 50.1343664673437 0 0 0.0147055780339792 0.999561172546954 0.998976222751812 0.99985749905819 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 13 3) Uncertain significance No change no 1 +Delamanid ddn p.Gly38fs ddn_p.Gly38fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 248 11394 0.00401606425702811 0.000101672774685082 0.0221717421523238 1 0.999676296088332 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 1.17330688615895 Inf 0.0213862406596237 17.5 609 False False Inf 1.17330688615895 Inf 0.00401606425702811 0.000101672774685082 0.0221717421523238 1 0.999676296088332 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim UP from Uncertain to AwRI no 4 +Delamanid ddn p.Gly53Asp ddn_p.Gly53Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Delamanid ddn p.Gly70Val ddn_p.Gly70Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 567 609 False False 0 0 111.334370311011 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Delamanid ddn p.Gly81Ser ddn_p.Gly81Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 247 11394 0.00803212851405622 0.00097421250436962 0.028711995092973 1 0.999676296088332 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 1.17803790716594 Inf 0.021302181755712 10.5 609 False False Inf 8.61397407191288 Inf 0.00403225806451612 0.000102082724624565 0.0222603214420216 1 0.999676296088332 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 17 3) Uncertain significance New Uncertain no 0 +Delamanid ddn p.Ile144Thr ddn_p.Ile144Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid ddn p.Ile74Val ddn_p.Ile74Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 577 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid ddn p.Leu49Pro ddn_p.Leu49Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 11 11 0 11 2 238 11392 0.0441767068273092 0.0222561067987681 0.0776681128429493 0.999824469018782 0.99936606710312 0.999978741676894 0.846153846153846 0.545528944323442 0.980793328017471 1 0.715085847081845 1 0.846153846153846 0.545528944323442 0.980793328017471 Inf 119.298600043917 Inf 3.44386534243609e-19 1 609 True False 263.26050420168 56.7813836207651 2512.43920673227 0.0441767068273092 0.0222561067987681 0.0776681128429493 0.999824469018782 0.99936606710312 0.999978741676894 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 13 Assoc w RI Evidence from ALL dataset only 2) Assoc w R - Interim no change yes ALL only 1 +Delamanid ddn p.Leu64fs ddn_p.Leu64fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim New AwRI no 5 +Delamanid ddn p.Leu90fs ddn_p.Leu90fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 247 11394 0.00803212851405622 0.00097421250436962 0.028711995092973 1 0.999676296088332 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 568 609 False False Inf 8.61397407191288 Inf 0 0 0.0148237646055962 1 0.999676296088332 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 53 506 0.0185185185185185 0.00046873840381796 0.0989151595078512 1 0.992736233998274 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 75 83 False False 0 0 0 0 0 0 0 Inf 0.240265883472405 Inf 0 0 0.0672345463063011 1 0.992736233998274 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim UP from Uncertain to AwRI no 4 +Delamanid ddn p.Lys104fs ddn_p.Lys104fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 248 11394 0.00401606425702811 0.000101672774685082 0.0221717421523238 1 0.999676296088332 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 576 609 False False Inf 1.17330688615895 Inf 0 0 0.0147644348125545 1 0.999676296088332 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim UP from Uncertain to AwRI no 4 +Delamanid ddn p.Met28fs ddn_p.Met28fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim New AwRI no 5 +Delamanid ddn p.Met87Ile ddn_p.Met87Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Delamanid ddn p.Phe16Cys ddn_p.Phe16Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 0 0 0.975 0 0 0.975 0 0 363.375224416517 1 34 83 False False 0 0 0 0 0 0 0 0 0 363.375224416517 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 NA 3) Uncertain significance New Uncertain no 0 +Delamanid ddn p.Phe17Ser ddn_p.Phe17Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid ddn p.Phe66Ser ddn_p.Phe66Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid ddn p.Pro124Ser ddn_p.Pro124Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Delamanid ddn p.Pro45Leu ddn_p.Pro45Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Delamanid ddn p.Pro59Gln ddn_p.Pro59Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 1735.91967638177 1 47 609 False False 0 0 111.334370311011 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 54 504 0 0 0.0660315142444217 0.996047430830039 0.985795485070057 0.999520966589986 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 77 83 False False 0 0 0 0 0 0 0 0 0 50.236220806896 0 0 0.0660315142444217 0.996047430830039 0.985795485070057 0.999520966589986 NA 3) Uncertain significance New Uncertain no 0 +Delamanid ddn p.Pro5fs ddn_p.Pro5fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 247 11394 0.00803212851405622 0.00097421250436962 0.028711995092973 1 0.999676296088332 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 1.17803790716594 Inf 0.021302181755712 10.5 609 False False Inf 8.61397407191288 Inf 0.00403225806451612 0.000102082724624565 0.0222603214420216 1 0.999676296088332 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim UP from Uncertain to AwRI no 4 +Delamanid ddn p.Pro6Thr ddn_p.Pro6Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 3) Uncertain significance No change no 1 +Delamanid ddn p.Thr115Ala ddn_p.Thr115Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid ddn p.Thr40Ala ddn_p.Thr40Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 572 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid ddn p.Thr56Ala ddn_p.Thr56Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 578 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Delamanid ddn p.Trp139* ddn_p.Trp139* 1 stop_gained (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 246 11394 0.0120481927710843 0.00249155218688723 0.0348042232340379 1 0.999676296088332 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 575 609 False False Inf 19.0139189471509 Inf 0 0 0.0148835731382165 1 0.999676296088332 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 1 0 53 506 0.0185185185185185 0.00046873840381796 0.0989151595078512 1 0.992736233998274 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.240265883472405 Inf 0.0964285714285713 5 83 False False 0 0 0 0 0 0 0 Inf 0.240265883472405 Inf 0.0185185185185185 0.00046873840381796 0.0989151595078512 1 0.992736233998274 1 11 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim UP from Uncertain to AwRI no 4 +Delamanid ddn p.Trp20* ddn_p.Trp20* 1 stop_gained (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 247 11394 0.00803212851405622 0.00097421250436962 0.028711995092973 1 0.999676296088332 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 581 609 False False Inf 8.61397407191288 Inf 0 0 0.0148237646055962 1 0.999676296088332 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim UP from Uncertain to AwRI no 4 +Delamanid ddn p.Trp88Arg ddn_p.Trp88Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 248 11394 0.00401606425702811 0.000101672774685082 0.0221717421523238 1 0.999676296088332 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 1.17330688615895 Inf 0.0213862406596237 17.5 609 False False Inf 1.17330688615895 Inf 0.00401606425702811 0.000101672774685082 0.0221717421523238 1 0.999676296088332 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Delamanid ddn p.Trp88* ddn_p.Trp88* 1 stop_gained (see "Genomic_coordinates" sheet) 1 5 3 2 3 2 246 11392 0.0120481927710843 0.00249155218688723 0.0348042232340379 0.999824469018782 0.99936606710312 0.999978741676894 0.6 0.146632799634673 0.947255049473683 0.6 0.146632799634673 0.947255049473683 0.6 0.146632799634673 0.947255049473683 69.4634146341463 7.90032754791461 834.645625612339 9.3625547482597e-05 4 609 True False 69.4634146341463 7.90032754791461 834.645625612339 0.0120481927710843 0.00249155218688723 0.0348042232340379 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 53 505 0.0185185185185185 0.00046873840381796 0.0989151595078512 0.998023715415019 0.989038460642947 0.999949966058094 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 9.52830188679245 0.119151989137674 744.381847950213 0.18371454127268 8 83 False False 0 0 0 0 0 0 0 9.52830188679245 0.119151989137674 744.381847950213 0.0185185185185185 0.00046873840381796 0.0989151595078512 0.998023715415019 0.989038460642947 0.999949966058094 36 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim UP from Uncertain to AwRI AwRI by relaxed thresholds (not endorsed) no O 4 +Delamanid ddn p.Tyr122_Met129del ddn_p.Tyr122_Met129del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 3 3 0 3 0 246 11394 0.0120481927710843 0.00249155218688723 0.0348042232340379 1 0.999676296088332 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 19.0139189471509 Inf 9.6664097280189e-06 3 609 True False Inf 19.0139189471509 Inf 0.0120481927710843 0.00249155218688723 0.0348042232340379 1 0.999676296088332 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Delamanid ddn p.Tyr29del ddn_p.Tyr29del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 247 11394 0.00803212851405622 0.00097421250436962 0.028711995092973 1 0.999676296088332 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 8.61397407191288 Inf 0.000455573585602705 7 609 True False Inf 8.61397407191288 Inf 0.00803212851405622 0.00097421250436962 0.028711995092973 1 0.999676296088332 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 53 506 0.0185185185185185 0.00046873840381796 0.0989151595078512 1 0.992736233998274 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.240265883472405 Inf 0.0964285714285713 5 83 False False 0 0 0 0 0 0 0 Inf 0.240265883472405 Inf 0.0185185185185185 0.00046873840381796 0.0989151595078512 1 0.992736233998274 1 2 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Delamanid ddn p.Tyr65Ser ddn_p.Tyr65Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 1 2 248 11392 0.00401606425702811 0.000101672774685082 0.0221717421523238 0.999824469018782 0.99936606710312 0.999978741676894 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 22.9677419354838 0.387752230133854 440.62889055685 0.0628016676317913 28.5 609 False False 22.9677419354838 0.387752230133854 440.62889055685 0.00401606425702811 0.000101672774685082 0.0221717421523238 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Delamanid ddn p.Val106Met ddn_p.Val106Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid ddn p.Val127Phe ddn_p.Val127Phe 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 2 246 11392 0.0120481927710843 0.00249155218688723 0.0348042232340379 0.999824469018782 0.99936606710312 0.999978741676894 0.6 0.146632799634673 0.947255049473683 NA NA NA 0 0 0.841886116991581 NA NA NA NA 569 609 False False 69.4634146341463 7.90032754791461 834.645625612339 0 0 0.0148835731382165 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 1 51 505 0.0555555555555555 0.0116067743799413 0.153885033791633 0.998023715415019 0.989038460642947 0.999949966058094 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 76 83 False False 0 0 0 0 0 0 0 29.7058823529411 2.30493612404462 1545.8097550793 0 0 0.0697770307495386 0.998023715415019 0.989038460642947 0.999949966058094 1 3) Uncertain significance New Uncertain no 0 +Delamanid ddn p.Val98Ala ddn_p.Val98Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiA c.-101A>T fbiA_c.-101A>T 1 upstream_gene_variant 3640442 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 459 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiA c.-104C>A fbiA_c.-104C>A 1 upstream_gene_variant 3640439 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Delamanid fbiA c.-105T>C fbiA_c.-105T>C 1 upstream_gene_variant 3640438 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fbiA c.-10G>A fbiA_c.-10G>A 1 upstream_gene_variant 3640533 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fbiA c.-115C>G fbiA_c.-115C>G 1 upstream_gene_variant 3640428 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 467 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fbiA c.-115C>T fbiA_c.-115C>T 1 upstream_gene_variant 3640428 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 464 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fbiA c.-128T>C fbiA_c.-128T>C 1 upstream_gene_variant 3640415 1 0 0 0 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 460 609 False False 0 0 111.334370311011 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance New Uncertain no 0 +Delamanid fbiA c.-129G>A fbiA_c.-129G>A 1 upstream_gene_variant 3640414 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiA c.-129G>T fbiA_c.-129G>T 1 upstream_gene_variant 3640414 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fbiA c.129T>C fbiA_c.129T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.334370311011 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 14 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiA c.-136G>A fbiA_c.-136G>A 1 upstream_gene_variant 3640407 1 4 0 4 0 5 249 11389 0 0 0.0147055780339792 0.999561172546954 0.998976222751812 0.99985749905819 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 69.5491050245269 1 245.5 609 False False 0 0 50.1343664673437 0 0 0.0147055780339792 0.999561172546954 0.998976222751812 0.99985749905819 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 10 3) Uncertain significance No change no 1 +Delamanid fbiA c.-13A>C fbiA_c.-13A>C 1 upstream_gene_variant 3640530 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fbiA c.150C>T fbiA_c.150C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiA c.15T>C fbiA_c.15T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 0 NA NA NA 2 49 247 11345 0.00803212851405622 0.00097421250436962 0.028711995092973 0.995699490960154 0.994318438411385 0.996816816935456 0.0392156862745098 0.00478499269470729 0.134586491129664 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.87474179955382 0.219594877496952 7.21432973617414 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 54 502 0 0 0.0660315142444217 0.992094861660079 0.979884247585768 0.997842037142001 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 14.3726282891803 NA NA NA NA NA NA 928 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiA c.162C>T fbiA_c.162C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiA c.-16G>A fbiA_c.-16G>A 1 upstream_gene_variant 3640527 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Delamanid fbiA c.180G>T fbiA_c.180G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiA c.195C>T fbiA_c.195C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiA c.204C>G fbiA_c.204C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 244.222407132781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 54 504 0 0 0.0660315142444217 0.996047430830039 0.985795485070057 0.999520966589986 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 50.236220806896 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiA c.-20G>A fbiA_c.-20G>A 1 upstream_gene_variant 3640523 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 462 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fbiA c.213C>T fbiA_c.213C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 0 NA NA NA 1 1 248 11393 0.00401606425702811 0.000101672774685082 0.0221717421523238 0.99991223450939 0.999511100073968 0.999997777972629 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 45.9395161290322 0.582902810663616 3482.48283416238 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiA c.264C>T fbiA_c.264C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiA c.-26G>A fbiA_c.-26G>A 1 upstream_gene_variant 3640517 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 473 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fbiA c.270G>A fbiA_c.270G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiA c.-27G>A fbiA_c.-27G>A 1 upstream_gene_variant 3640516 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 446 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Delamanid fbiA c.288C>T fbiA_c.288C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiA c.318C>T fbiA_c.318C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiA c.337C>T fbiA_c.337C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 0 NA NA NA 3 57 246 11337 0.0120481927710843 0.00249155218688723 0.0348042232340379 0.994997367035281 0.993523304748716 0.996208918050577 0.05 0.0104323296443482 0.139243246721072 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.42554557124518 0.482497517574724 7.53567962835103 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 363.375224416517 NA NA NA NA NA NA 115 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiA c.372C>T fbiA_c.372C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 244.222407132781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiA c.432T>G fbiA_c.432T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 11 249 11383 0 0 0.0147055780339792 0.9990345796033 0.99827325433968 0.99951797022408 0 0 0.284914152918154 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 18.324112815918 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 77 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiA c.468C>T fbiA_c.468C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 249 11390 0 0 0.0147055780339792 0.999648938037563 0.999101388115099 0.99990433941184 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 69.5552063788676 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 14 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiA c.471C>T fbiA_c.471C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.334370311011 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 363.375224416517 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiA c.51C>A fbiA_c.51C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiA c.-51G>A fbiA_c.-51G>A 1 upstream_gene_variant 3640492 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiA c.522G>A fbiA_c.522G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiA c.546G>T fbiA_c.546G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiA c.615C>T fbiA_c.615C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 7 249 11387 0 0 0.0147055780339792 0.999385641565736 0.998734599099098 0.99975296150752 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.8900809629541 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiA c.-63_-59delCGTGT fbiA_c.-63_-59delCGTGT 1 upstream_gene_variant 3640479 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 463 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Delamanid fbiA c.666C>T fbiA_c.666C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiA c.-66C>T fbiA_c.-66C>T 1 upstream_gene_variant 3640477 1 1 0 1 1 1 248 11393 0.00401606425702811 0.000101672774685082 0.0221717421523238 0.99991223450939 0.999511100073968 0.999997777972629 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 1743.02637428834 1 245.5 609 False False 45.9395161290322 0.582902810663616 3482.48283416238 0 0 0.0147644348125545 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiA c.672G>A fbiA_c.672G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiA c.693G>T fbiA_c.693G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.334370311011 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiA c.696G>A fbiA_c.696G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 244.222407132781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 363.375224416517 NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiA c.-69T>C fbiA_c.-69T>C 1 upstream_gene_variant 3640474 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiA c.72C>T fbiA_c.72C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiA c.744C>A fbiA_c.744C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 0 248 11394 0.00401606425702811 0.000101672774685082 0.0221717421523238 1 0.999676296088332 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.17330688615895 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiA c.744C>T fbiA_c.744C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.334370311011 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 363.375224416517 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiA c.75G>A fbiA_c.75G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiA c.75G>C fbiA_c.75G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiA c.-75G>C fbiA_c.-75G>C 1 upstream_gene_variant 3640468 1 4 1 3 1 3 248 11391 0.00401606425702811 0.000101672774685082 0.0221717421523238 0.999736703528172 0.999230730695071 0.999945698645904 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 15.3104838709677 0.290482936930346 191.361367823419 0.0828499824736885 30.5 609 False False 15.3104838709677 0.290482936930346 191.361367823419 0.00401606425702811 0.000101672774685082 0.0221717421523238 0.999736703528172 0.999230730695071 0.999945698645904 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 54 504 0 0 0.0660315142444217 0.996047430830039 0.985795485070057 0.999520966589986 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 50.236220806896 1 34 83 False False 0 0 0 0 0 0 0 0 0 50.236220806896 0 0 0.0660315142444217 0.996047430830039 0.985795485070057 0.999520966589986 18 3) Uncertain significance No change no 1 +Delamanid fbiA c.792G>T fbiA_c.792G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiA c.-7C>G fbiA_c.-7C>G 1 upstream_gene_variant 3640536 1 0 0 0 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 452 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fbiA c.816G>A fbiA_c.816G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiA c.81G>A fbiA_c.81G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiA c.-81G>A fbiA_c.-81G>A 1 upstream_gene_variant 3640462 1 2 0 2 0 4 249 11390 0 0 0.0147055780339792 0.999648938037563 0.999101388115099 0.99990433941184 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 244.179524589186 1 245.5 609 False False 0 0 69.5552063788676 0 0 0.0147055780339792 0.999648938037563 0.999101388115099 0.99990433941184 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Delamanid fbiA c.837G>A fbiA_c.837G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 244.222407132781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiA c.843C>G fbiA_c.843C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 244.222407132781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiA c.852A>T fbiA_c.852A>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 249 11390 0 0 0.0147055780339792 0.999648938037563 0.999101388115099 0.99990433941184 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 69.5552063788676 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiA c.867G>A fbiA_c.867G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.334370311011 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiA c.888T>C fbiA_c.888T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 244.222407132781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 363.375224416517 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiA c.900G>A fbiA_c.900G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 248 11394 0.00401606425702811 0.000101672774685082 0.0221717421523238 1 0.999676296088332 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.17330688615895 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 53 506 0.0185185185185185 0.00046873840381796 0.0989151595078512 1 0.992736233998274 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.240265883472405 Inf NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiA c.903G>A fbiA_c.903G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 244.222407132781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiA c.912G>A fbiA_c.912G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 9 249 11385 0 0 0.0147055780339792 0.999210110584518 0.998501075795816 0.999638750670416 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 23.2953648317795 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 15 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiA c.925C>T fbiA_c.925C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiA c.936C>T fbiA_c.936C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiA c.978T>C fbiA_c.978T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiA c.-97A>T fbiA_c.-97A>T 1 upstream_gene_variant 3640446 1 16 0 16 0 18 249 11376 0 0 0.0147055780339792 0.998420221169036 0.997504413129461 0.999063462626473 0 0 0.185301968137852 0 0 0.205907214207822 0 0 0.185301968137852 0 0 11.9198777482725 1 245.5 609 False False 0 0 10.463148258376 0 0 0.0147055780339792 0.998420221169036 0.997504413129461 0.999063462626473 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 29 3) Uncertain significance No change no 1 +Delamanid fbiA c.-98delA fbiA_c.-98delA 1 upstream_gene_variant 3640444 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fbiA LoF fbiA_LoF 1 LoF (see "Genomic_coordinates" sheet) 0 0 0 0 2 1 247 11393 0.00803212851405622 0.00097421250436962 0.028711995092973 0.99991223450939 0.999511100073968 0.999997777972629 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 607 609 False False 92.251012145749 4.774655003888 5198.14310674614 0 0 0.0148237646055962 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 1 52 505 0.037037037037037 0.00451725629446049 0.127471772230947 0.998023715415019 0.989038460642947 0.999949966058094 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 82 83 False False 0 0 0 0 0 0 0 19.4230769230769 0.983783936598918 1138.32179495312 0 0 0.0684822087033195 0.998023715415019 0.989038460642947 0.999949966058094 NA Marker of R Selection evidence 2) Assoc w R - Interim Confers DLM-PMD cross-resistance New AwRI yes Selection R 5 +Delamanid fbiA p.Ala178Thr fbiA_p.Ala178Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 466 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 3) Uncertain significance No change no 1 +Delamanid fbiA p.Ala190Thr fbiA_p.Ala190Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 454 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiA p.Ala199Thr fbiA_p.Ala199Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 244.222407132781 1 245.5 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 3) Uncertain significance No change no 1 +Delamanid fbiA p.Ala206Thr fbiA_p.Ala206Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 248 11393 0.00401606425702811 0.000101672774685082 0.0221717421523238 0.99991223450939 0.999511100073968 0.999997777972629 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 1743.02637428834 1 245.5 609 False False 45.9395161290322 0.582902810663616 3482.48283416238 0 0 0.0147644348125545 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance No change no 1 +Delamanid fbiA p.Ala222Thr fbiA_p.Ala222Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 470 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiA p.Ala29Thr fbiA_p.Ala29Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiA p.Ala30Val fbiA_p.Ala30Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 461 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Delamanid fbiA p.Ala327Thr fbiA_p.Ala327Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 443 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fbiA p.Ala33Asp fbiA_p.Ala33Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiA p.Ala43Thr fbiA_p.Ala43Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 249 11390 0 0 0.0147055780339792 0.999648938037563 0.999101388115099 0.99990433941184 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 69.5552063788676 1 245.5 609 False False 0 0 69.5552063788676 0 0 0.0147055780339792 0.999648938037563 0.999101388115099 0.99990433941184 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Delamanid fbiA p.Arg175His fbiA_p.Arg175His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Delamanid fbiA p.Arg177His fbiA_p.Arg177His 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 249 11390 0 0 0.0147055780339792 0.999648938037563 0.999101388115099 0.99990433941184 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 447 609 False False 0 0 69.5552063788676 0 0 0.0147055780339792 0.999648938037563 0.999101388115099 0.99990433941184 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fbiA p.Arg304Gln fbiA_p.Arg304Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 448 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 57 83 False False 0 0 0 0 0 0 0 0 0 363.375224416517 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 10 3) Uncertain significance No change no 1 +Delamanid fbiA p.Arg321Ser fbiA_p.Arg321Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 247 11394 0.00803212851405622 0.00097421250436962 0.028711995092973 1 0.999676296088332 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 8.61397407191288 Inf 0.000455573585602705 7 609 True False Inf 8.61397407191288 Inf 0.00803212851405622 0.00097421250436962 0.028711995092973 1 0.999676296088332 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Delamanid fbiA p.Asn314Lys fbiA_p.Asn314Lys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 248 11394 0.00401606425702811 0.000101672774685082 0.0221717421523238 1 0.999676296088332 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 453 609 False False Inf 1.17330688615895 Inf 0 0 0.0147644348125545 1 0.999676296088332 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiA p.Asp100Asn fbiA_p.Asp100Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiA p.Asp292Gly fbiA_p.Asp292Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 0 0 0.975 0 0 0.975 0 0 363.375224416517 1 34 83 False False 0 0 0 0 0 0 0 0 0 363.375224416517 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 NA 3) Uncertain significance New Uncertain no 0 +Delamanid fbiA p.Asp299Ala fbiA_p.Asp299Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Delamanid fbiA p.Asp312Gly fbiA_p.Asp312Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 441 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 25 3) Uncertain significance New Uncertain no 0 +Delamanid fbiA p.Cys280Gly fbiA_p.Cys280Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 248 11394 0.00401606425702811 0.000101672774685082 0.0221717421523238 1 0.999676296088332 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 1.17330688615895 Inf 0.0213862406596237 17.5 609 False False Inf 1.17330688615895 Inf 0.00401606425702811 0.000101672774685082 0.0221717421523238 1 0.999676296088332 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fbiA p.Cys280Ser fbiA_p.Cys280Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiA p.Cys287Tyr fbiA_p.Cys287Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fbiA p.Gln120Arg fbiA_p.Gln120Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 7 249 11387 0 0 0.0147055780339792 0.999385641565736 0.998734599099098 0.99975296150752 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 31.8900809629541 1 245.5 609 False False 0 0 31.8900809629541 0 0 0.0147055780339792 0.999385641565736 0.998734599099098 0.99975296150752 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Delamanid fbiA p.Gln21Leu fbiA_p.Gln21Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiA p.Gln27Pro fbiA_p.Gln27Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 111.334370311011 1 245.5 609 False False 0 0 111.334370311011 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Delamanid fbiA p.Glu130Asp fbiA_p.Glu130Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 457 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fbiA p.Glu130Lys fbiA_p.Glu130Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 445 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiA p.Gly189Ser fbiA_p.Gly189Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fbiA p.Gly264Arg fbiA_p.Gly264Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 19 0 19 0 22 249 11372 0 0 0.0147055780339792 0.9980691592066 0.99707813467376 0.998789569083863 0 0 0.154372512815574 0 0 0.176466911806965 0 0 0.154372512815574 0 0 9.85405724288412 1 245.5 609 False False 0 0 8.39171674970539 0 0 0.0147055780339792 0.9980691592066 0.99707813467376 0.998789569083863 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 53 3) Uncertain significance No change no 1 +Delamanid fbiA p.Gly26Ser fbiA_p.Gly26Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fbiA p.Gly277Ser fbiA_p.Gly277Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Delamanid fbiA p.Gly293Ala fbiA_p.Gly293Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 472 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Delamanid fbiA p.Gly48Ser fbiA_p.Gly48Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiA p.Gly70Ser fbiA_p.Gly70Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Delamanid fbiA p.Gly78Ser fbiA_p.Gly78Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fbiA p.His183Gln fbiA_p.His183Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 248 11393 0.00401606425702811 0.000101672774685082 0.0221717421523238 0.99991223450939 0.999511100073968 0.999997777972629 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 45.9395161290322 0.582902810663616 3482.48283416238 0.0423169077336449 26.5 609 False False 45.9395161290322 0.582902810663616 3482.48283416238 0.00401606425702811 0.000101672774685082 0.0221717421523238 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiA p.His295Arg fbiA_p.His295Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 249 11389 0 0 0.0147055780339792 0.999561172546954 0.998976222751812 0.99985749905819 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 50.1343664673437 1 245.5 609 False False 0 0 50.1343664673437 0 0 0.0147055780339792 0.999561172546954 0.998976222751812 0.99985749905819 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiA p.Ile208Val fbiA_p.Ile208Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 32 0 32 0 38 249 11356 0 0 0.0147055780339792 0.996664911356854 0.995425175415507 0.997638844601611 0 0 0.0925127614158782 0 0 0.108881160679352 0 0 0.0925127614158782 0 0 5.61251169746932 1 245.5 609 False False 0 0 4.68265252801763 0 0 0.0147055780339792 0.996664911356854 0.995425175415507 0.997638844601611 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 0 0 0.975 0 0 0.975 0 0 363.375224416517 1 34 83 False False 0 0 0 0 0 0 0 0 0 363.375224416517 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 142 3) Uncertain significance No change no 1 +Delamanid fbiA p.Ile229Met fbiA_p.Ile229Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiA p.Ile229Val fbiA_p.Ile229Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 455 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 54 504 0 0 0.0660315142444217 0.996047430830039 0.985795485070057 0.999520966589986 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 58 83 False False 0 0 0 0 0 0 0 0 0 50.236220806896 0 0 0.0660315142444217 0.996047430830039 0.985795485070057 0.999520966589986 NA 3) Uncertain significance New Uncertain no 0 +Delamanid fbiA p.Ile53Thr fbiA_p.Ile53Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 248 11394 0.00401606425702811 0.000101672774685082 0.0221717421523238 1 0.999676296088332 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 1.17330688615895 Inf 0.0213862406596237 17.5 609 False False Inf 1.17330688615895 Inf 0.00401606425702811 0.000101672774685082 0.0221717421523238 1 0.999676296088332 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Delamanid fbiA p.Ile53Val fbiA_p.Ile53Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fbiA p.Leu104Phe fbiA_p.Leu104Phe 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 248 11394 0.00401606425702811 0.000101672774685082 0.0221717421523238 1 0.999676296088332 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 465 609 False False Inf 1.17330688615895 Inf 0 0 0.0147644348125545 1 0.999676296088332 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Delamanid fbiA p.Leu132Val fbiA_p.Leu132Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 458 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fbiA p.Leu22Val fbiA_p.Leu22Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 111.334370311011 1 245.5 609 False False 0 0 111.334370311011 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 3) Uncertain significance No change no 1 +Delamanid fbiA p.Lys192Glu fbiA_p.Lys192Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fbiA p.Phe102Leu fbiA_p.Phe102Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiA p.Pro227Thr fbiA_p.Pro227Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 450 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiA p.Pro239Ser fbiA_p.Pro239Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Delamanid fbiA p.Pro245Ser fbiA_p.Pro245Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 451 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fbiA p.Ser184Thr fbiA_p.Ser184Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 248 11393 0.00401606425702811 0.000101672774685082 0.0221717421523238 0.99991223450939 0.999511100073968 0.999997777972629 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 45.9395161290322 0.582902810663616 3482.48283416238 0.0423169077336449 26.5 609 False False 45.9395161290322 0.582902810663616 3482.48283416238 0.00401606425702811 0.000101672774685082 0.0221717421523238 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Delamanid fbiA p.Ser194Gly fbiA_p.Ser194Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fbiA p.Ser32Phe fbiA_p.Ser32Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiA p.Ser35Ala fbiA_p.Ser35Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 1 5 1 5 248 11389 0.00401606425702811 0.000101672774685082 0.0221717421523238 0.999561172546954 0.998976222751812 0.99985749905819 0.166666666666666 0.00421074451448947 0.641234578997674 0.166666666666666 0.00421074451448947 0.641234578997674 0.166666666666666 0.00421074451448947 0.641234578997674 9.18467741935484 0.193417807211944 82.3894727820671 0.121674129728306 33.5 609 False False 9.18467741935484 0.193417807211944 82.3894727820671 0.00401606425702811 0.000101672774685082 0.0221717421523238 0.999561172546954 0.998976222751812 0.99985749905819 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiA p.Ser42Cys fbiA_p.Ser42Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fbiA p.Ser42Gly fbiA_p.Ser42Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiA p.Thr302Ala fbiA_p.Thr302Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 456 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Delamanid fbiA p.Thr302Met fbiA_p.Thr302Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 79 1 78 2 91 247 11303 0.00803212851405622 0.00097421250436962 0.028711995092973 0.992013340354572 0.990203082976019 0.993564906197624 0.021505376344086 0.002615094697133 0.0755329720525083 0.0126582278481012 0.000320427234304267 0.0685199094867721 0.0108695652173913 0.000275155702770738 0.0590778511498147 0.586681200041523 0.0146120471955651 3.3968925897613 1 245.5 609 False False 1.00573920007118 0.119309557389289 3.77778167952808 0.00403225806451612 0.000102082724624565 0.0222603214420216 0.992013340354572 0.990203082976019 0.993564906197624 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 16 0 16 1 18 53 488 0.0185185185185185 0.00046873840381796 0.0989151595078512 0.964426877470355 0.944360428001627 0.978783389339805 0.0526315789473684 0.00133162880417942 0.260280654195214 0 0 0.205907214207822 0 0 0.185301968137852 0 0 2.47133752783044 0.385469437127768 10 83 False False 0 0 0 0 0 0 0 0.511530398322851 0.0120561159677592 3.37466069966016 0 0 0.0672345463063011 0.964426877470355 0.944360428001627 0.978783389339805 514 3) Uncertain significance No change no 1 +Delamanid fbiA p.Thr4Asn fbiA_p.Thr4Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 444 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiA p.Trp101Cys fbiA_p.Trp101Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fbiA p.Val114Leu fbiA_p.Val114Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiA p.Val160Ile fbiA_p.Val160Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiA p.Val180Met fbiA_p.Val180Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiA p.Val188Ala fbiA_p.Val188Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 471 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiA p.Val188Ile fbiA_p.Val188Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 11 0 11 0 11 249 11383 0 0 0.0147055780339792 0.9990345796033 0.99827325433968 0.99951797022408 0 0 0.284914152918154 0 0 0.284914152918154 0 0 0.284914152918154 0 0 18.324112815918 1 245.5 609 False False 0 0 18.324112815918 0 0 0.0147055780339792 0.9990345796033 0.99827325433968 0.99951797022408 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Delamanid fbiA p.Val188Phe fbiA_p.Val188Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 244.222407132781 1 245.5 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 17 3) Uncertain significance No change no 1 +Delamanid fbiA p.Val217Gly fbiA_p.Val217Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 442 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fbiA p.Val217Met fbiA_p.Val217Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 468 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiA p.Val265Met fbiA_p.Val265Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 449 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiA p.Val306Met fbiA_p.Val306Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 111.334370311011 1 245.5 609 False False 0 0 111.334370311011 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fbiA p.Val329fs fbiA_p.Val329fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 2 1 247 11393 0.00803212851405622 0.00097421250436962 0.028711995092973 0.99991223450939 0.999511100073968 0.999997777972629 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 474 609 False False 92.251012145749 4.774655003888 5198.14310674614 0 0 0.0148237646055962 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 1 52 505 0.037037037037037 0.00451725629446049 0.127471772230947 0.998023715415019 0.989038460642947 0.999949966058094 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 60 83 False False 0 0 0 0 0 0 0 19.4230769230769 0.983783936598918 1138.32179495312 0 0 0.0684822087033195 0.998023715415019 0.989038460642947 0.999949966058094 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim New AwRI no 5 +Delamanid fbiA p.Val47Ile fbiA_p.Val47Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 248 11393 0.00401606425702811 0.000101672774685082 0.0221717421523238 0.99991223450939 0.999511100073968 0.999997777972629 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 469 609 False False 45.9395161290322 0.582902810663616 3482.48283416238 0 0 0.0147644348125545 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 53 506 0.0185185185185185 0.00046873840381796 0.0989151595078512 1 0.992736233998274 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 59 83 False False 0 0 0 0 0 0 0 Inf 0.240265883472405 Inf 0 0 0.0672345463063011 1 0.992736233998274 1 4 3) Uncertain significance No change no 1 +Delamanid fbiB c.1041C>A fbiB_c.1041C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 244.222407132781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiB c.1050G>A fbiB_c.1050G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 363.375224416517 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiB c.1095C>G fbiB_c.1095C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 7 249 11387 0 0 0.0147055780339792 0.999385641565736 0.998734599099098 0.99975296150752 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.8900809629541 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 40 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiB c.1122G>A fbiB_c.1122G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 244.222407132781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiB c.1164G>C fbiB_c.1164G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiB c.1206C>T fbiB_c.1206C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiB c.1266C>G fbiB_c.1266C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiB c.1272C>T fbiB_c.1272C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiB c.1293G>A fbiB_c.1293G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiB c.1330T>C fbiB_c.1330T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 0 NA NA NA 1 0 248 11394 0.00401606425702811 0.000101672774685082 0.0221717421523238 1 0.999676296088332 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.17330688615895 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 NA NA NA 1 0 53 506 0.0185185185185185 0.00046873840381796 0.0989151595078512 1 0.992736233998274 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.240265883472405 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiB c.1335G>A fbiB_c.1335G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 246 11394 0.0120481927710843 0.00249155218688723 0.0348042232340379 1 0.999676296088332 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 19.0139189471509 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 51 506 0.0555555555555555 0.0116067743799413 0.153885033791633 1 0.992736233998274 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 3.96164470012735 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiB c.135C>A fbiB_c.135C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiB c.150C>T fbiB_c.150C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiB c.156G>A fbiB_c.156G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 244.222407132781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiB c.171G>A fbiB_c.171G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 0 NA NA NA 1 0 248 11394 0.00401606425702811 0.000101672774685082 0.0221717421523238 1 0.999676296088332 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.17330688615895 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiB c.174C>T fbiB_c.174C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiB c.198C>T fbiB_c.198C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiB c.207A>G fbiB_c.207A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiB c.21C>T fbiB_c.21C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiB c.243G>A fbiB_c.243G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 244.222407132781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiB c.273C>G fbiB_c.273C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 10 249 11384 0 0 0.0147055780339792 0.999122345093909 0.998386555629556 0.999579052676482 0 0 0.30849710781876 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.5112934421461 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 14 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiB c.276G>C fbiB_c.276G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 16 248 11378 0.00401606425702811 0.000101672774685082 0.0221717421523238 0.998595752150254 0.997720588509296 0.99919714469723 0.0588235294117647 0.00148817439126663 0.28688939666722 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.86743951612903 0.0681064688509958 18.5935279534623 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 5 53 501 0.0185185185185185 0.00046873840381796 0.0989151595078512 0.990118577075098 0.977091674593924 0.996783963293044 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.89056603773584 0.0392399780131745 17.3276411830389 NA NA NA NA NA NA 145 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiB c.324G>A fbiB_c.324G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 5 248 11389 0.00401606425702811 0.000101672774685082 0.0221717421523238 0.999561172546954 0.998976222751812 0.99985749905819 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA NA NA NA NA NA NA NA NA NA False False 9.18467741935484 0.193417807211944 82.3894727820671 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 53 505 0.0185185185185185 0.00046873840381796 0.0989151595078512 0.998023715415019 0.989038460642947 0.999949966058094 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 9.52830188679245 0.119151989137674 744.381847950213 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiB c.361C>T fbiB_c.361C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 244.222407132781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 20 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiB c.408G>T fbiB_c.408G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiB c.471C>G fbiB_c.471C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 9 249 11385 0 0 0.0147055780339792 0.999210110584518 0.998501075795816 0.999638750670416 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 23.2953648317795 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 28 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiB c.517C>T fbiB_c.517C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiB c.546A>G fbiB_c.546A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiB c.552C>T fbiB_c.552C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiB c.564G>A fbiB_c.564G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 24 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiB c.573G>A fbiB_c.573G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 6 249 11388 0 0 0.0147055780339792 0.999473407056345 0.998854183895649 0.999806725936475 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 39.0576580619631 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiB c.57G>A fbiB_c.57G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiB c.60G>A fbiB_c.60G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 244.222407132781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiB c.636G>A fbiB_c.636G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 244.222407132781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiB c.636G>C fbiB_c.636G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiB c.639G>A fbiB_c.639G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 7 249 11387 0 0 0.0147055780339792 0.999385641565736 0.998734599099098 0.99975296150752 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.8900809629541 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 54 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiB c.654T>C fbiB_c.654T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.334370311011 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiB c.663C>A fbiB_c.663C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiB c.678C>T fbiB_c.678C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiB c.688C>A fbiB_c.688C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiB c.708C>A fbiB_c.708C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 363.375224416517 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiB c.738C>T fbiB_c.738C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiB c.759C>T fbiB_c.759C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiB c.762G>A fbiB_c.762G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiB c.810G>A fbiB_c.810G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 244.222407132781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiB c.84T>C fbiB_c.84T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiB c.888A>G fbiB_c.888A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiB c.903G>A fbiB_c.903G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 363.375224416517 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiB c.90C>T fbiB_c.90C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 3 2 246 11392 0.0120481927710843 0.00249155218688723 0.0348042232340379 0.999824469018782 0.99936606710312 0.999978741676894 0.6 0.146632799634673 0.947255049473683 NA NA NA NA NA NA NA NA NA NA NA NA False False 69.4634146341463 7.90032754791461 834.645625612339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 3 1 51 505 0.0555555555555555 0.0116067743799413 0.153885033791633 0.998023715415019 0.989038460642947 0.999949966058094 0.75 0.194120449683243 0.99369053679029 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 29.7058823529411 2.30493612404462 1545.8097550793 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiB c.921G>A fbiB_c.921G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiB c.936G>T fbiB_c.936G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiB c.969T>C fbiB_c.969T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiB LoF fbiB_LoF 1 LoF (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 609 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Marker of R Selection evidence 2) Assoc w R - Interim Confers DLM-PMD cross-resistance New AwRI yes Selection R 5 +Delamanid fbiB p.Ala127Thr fbiB_p.Ala127Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 545 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Delamanid fbiB p.Ala200Glu fbiB_p.Ala200Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fbiB p.Ala286Gly fbiB_p.Ala286Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Delamanid fbiB p.Ala304Asp fbiB_p.Ala304Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiB p.Ala31Thr fbiB_p.Ala31Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 59 3 56 3 58 246 11336 0.0120481927710843 0.00249155218688723 0.0348042232340379 0.994909601544672 0.993424386031568 0.996132445307596 0.0491803278688524 0.0102593151683207 0.137069221915894 0.0508474576271186 0.0106112803238798 0.141487239475254 0.0491803278688524 0.0102593151683207 0.137069221915894 2.46864111498257 0.490820325967765 7.67875466088744 0.131973228190127 35 609 False False 2.38351555929352 0.474369621163187 7.39994947298345 0.0120481927710843 0.00249155218688723 0.0348042232340379 0.994909601544672 0.993424386031568 0.996132445307596 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 80 3) Uncertain significance No change no 1 +Delamanid fbiB p.Ala32Val fbiB_p.Ala32Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Delamanid fbiB p.Ala36Val fbiB_p.Ala36Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 546 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fbiB p.Ala376Thr fbiB_p.Ala376Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiB p.Ala441Val fbiB_p.Ala441Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Delamanid fbiB p.Ala82Thr fbiB_p.Ala82Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 111.334370311011 1 245.5 609 False False 0 0 111.334370311011 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fbiB p.Arg157Cys fbiB_p.Arg157Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiB p.Arg174His fbiB_p.Arg174His 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 537 609 False False 0 0 111.334370311011 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiB p.Arg230Gln fbiB_p.Arg230Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 538 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 70 83 False False 0 0 0 0 0 0 0 0 0 363.375224416517 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 24 3) Uncertain significance New Uncertain no 0 +Delamanid fbiB p.Arg253His fbiB_p.Arg253His 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 111.334370311011 1 245.5 609 False False 0 0 111.334370311011 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fbiB p.Arg265Gln fbiB_p.Arg265Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 111.334370311011 1 245.5 609 False False 0 0 111.334370311011 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 3) Uncertain significance No change no 1 +Delamanid fbiB p.Arg293Gly fbiB_p.Arg293Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fbiB p.Arg334Gln fbiB_p.Arg334Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 540 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Delamanid fbiB p.Arg365Gly fbiB_p.Arg365Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 244.222407132781 1 245.5 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Delamanid fbiB p.Arg409Ser fbiB_p.Arg409Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 244.222407132781 1 245.5 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 0 0 0.975 0 0 0.975 0 0 363.375224416517 1 34 83 False False 0 0 0 0 0 0 0 0 0 363.375224416517 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 14 3) Uncertain significance No change no 1 +Delamanid fbiB p.Asp109Glu fbiB_p.Asp109Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fbiB p.Asp224Asn fbiB_p.Asp224Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 244.222407132781 1 245.5 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance No change no 1 +Delamanid fbiB p.Asp311Ala fbiB_p.Asp311Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 0 0 0.975 0 0 0.975 0 0 363.375224416517 1 34 83 False False 0 0 0 0 0 0 0 0 0 363.375224416517 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 NA 3) Uncertain significance New Uncertain no 0 +Delamanid fbiB p.Asp315Ala fbiB_p.Asp315Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 536 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 27 3) Uncertain significance New Uncertain no 0 +Delamanid fbiB p.Asp315His fbiB_p.Asp315His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fbiB p.Asp343Ala fbiB_p.Asp343Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fbiB p.Asp417Ala fbiB_p.Asp417Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Delamanid fbiB p.Asp430His fbiB_p.Asp430His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fbiB p.Asp437Ala fbiB_p.Asp437Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fbiB p.Asp437Gly fbiB_p.Asp437Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 244.222407132781 1 245.5 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fbiB p.Asp66Glu fbiB_p.Asp66Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 249 11389 0 0 0.0147055780339792 0.999561172546954 0.998976222751812 0.99985749905819 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 50.1343664673437 1 245.5 609 False False 0 0 50.1343664673437 0 0 0.0147055780339792 0.999561172546954 0.998976222751812 0.99985749905819 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Delamanid fbiB p.Asp90Asn fbiB_p.Asp90Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 111.334370311011 1 245.5 609 False False 0 0 111.334370311011 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 29 3) Uncertain significance No change no 1 +Delamanid fbiB p.Asp90Glu fbiB_p.Asp90Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 0 0 0.975 0 0 0.975 0 0 363.375224416517 1 34 83 False False 0 0 0 0 0 0 0 0 0 363.375224416517 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 NA 3) Uncertain significance New Uncertain no 0 +Delamanid fbiB p.Asp90Gly fbiB_p.Asp90Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiB p.Gln339Arg fbiB_p.Gln339Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 244.222407132781 1 245.5 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiB p.Gln69Arg fbiB_p.Gln69Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 1736.06792348613 1 245.5 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Delamanid fbiB p.Glu138Lys fbiB_p.Glu138Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 244.222407132781 1 245.5 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 0 0 0.975 0 0 0.975 0 0 363.375224416517 1 34 83 False False 0 0 0 0 0 0 0 0 0 363.375224416517 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 NA 3) Uncertain significance No change no 1 +Delamanid fbiB p.Glu191Asp fbiB_p.Glu191Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fbiB p.Glu191Gln fbiB_p.Glu191Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiB p.Glu65Lys fbiB_p.Glu65Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 541 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fbiB p.Gly19Glu fbiB_p.Gly19Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 535 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Delamanid fbiB p.Gly325Ser fbiB_p.Gly325Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 249 11390 0 0 0.0147055780339792 0.999648938037563 0.999101388115099 0.99990433941184 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 69.5552063788676 1 245.5 609 False False 0 0 69.5552063788676 0 0 0.0147055780339792 0.999648938037563 0.999101388115099 0.99990433941184 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 3) Uncertain significance No change no 1 +Delamanid fbiB p.Gly3Ser fbiB_p.Gly3Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fbiB p.His370Arg fbiB_p.His370Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 547 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fbiB p.Ile18Asn fbiB_p.Ile18Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Delamanid fbiB p.Ile18Thr fbiB_p.Ile18Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fbiB p.Ile446Thr fbiB_p.Ile446Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 244.222407132781 1 245.5 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiB p.Leu284Val fbiB_p.Leu284Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 550 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Delamanid fbiB p.Leu444Phe fbiB_p.Leu444Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 244.222407132781 1 245.5 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fbiB p.Leu447Arg fbiB_p.Leu447Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 33 0 33 0 33 249 11361 0 0 0.0147055780339792 0.9971037388099 0.995934954997775 0.998005533972291 0 0 0.105762810074579 0 0 0.105762810074579 0 0 0.105762810074579 0 0 5.43508073830966 1 439.5 609 False False 0 0 5.43508073830966 0 0 0.0147055780339792 0.9971037388099 0.995934954997775 0.998005533972291 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 107 3) Uncertain significance No change no 1 +Delamanid fbiB p.Lys206Asn fbiB_p.Lys206Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 244.222407132781 1 245.5 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fbiB p.Lys448Arg fbiB_p.Lys448Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 112 6 106 19 144 230 11250 0.0763052208835341 0.046564051999502 0.116596656793346 0.98736176935229 0.985137519012318 0.989331511518257 0.116564417177914 0.0716577219530755 0.176033574359759 0.0535714285714285 0.0199109453941111 0.11295965920432 0.04 0.014818521114898 0.0850278147181987 2.76866283839212 0.983328249891926 6.32005761563806 0.0267923100419707 25 609 False False 6.45380434782608 3.70753862444289 10.6743447579638 0.0254237288135593 0.00938595986789999 0.0545125658452052 0.98736176935229 0.985137519012318 0.989331511518257 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 40 5 35 17 46 37 460 0.314814814814814 0.195239411003191 0.455523994872843 0.909090909090909 0.880602817171507 0.932674254765114 0.269841269841269 0.16571257843396 0.396514719293492 0.125 0.0418596261386167 0.26803291736172 0.0980392156862745 0.0326064895518909 0.21414498254568 1.77606177606177 0.511919435424463 4.93977865210429 0.2273962786457 9 83 False False 0 0 0 0 0 0 0 4.59459459459459 2.23441665739576 9.11849470123697 0.119047619047619 0.0398055289426883 0.256316677606377 0.909090909090909 0.880602817171507 0.932674254765114 341 3) Uncertain significance No change no 1 +Delamanid fbiB p.Phe403Leu fbiB_p.Phe403Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiB p.Pro122Ala fbiB_p.Pro122Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiB p.Pro25Arg fbiB_p.Pro25Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 544 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fbiB p.Pro303Thr fbiB_p.Pro303Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiB p.Pro361Leu fbiB_p.Pro361Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fbiB p.Pro440Ser fbiB_p.Pro440Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 3) Uncertain significance No change no 1 +Delamanid fbiB p.Ser30Arg fbiB_p.Ser30Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 539 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fbiB p.Ser433Pro fbiB_p.Ser433Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 549 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Delamanid fbiB p.Thr212Ala fbiB_p.Thr212Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiB p.Thr268Ala fbiB_p.Thr268Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiB p.Thr268Ile fbiB_p.Thr268Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 1 248 11393 0.00401606425702811 0.000101672774685082 0.0221717421523238 0.99991223450939 0.999511100073968 0.999997777972629 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 1.17320391152844 Inf 0.0213880776498883 24 609 False False 45.9395161290322 0.582902810663616 3482.48283416238 0.00401606425702811 0.000101672774685082 0.0221717421523238 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Delamanid fbiB p.Thr292Ala fbiB_p.Thr292Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 244.222407132781 1 245.5 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiB p.Thr371Ile fbiB_p.Thr371Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 548 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Delamanid fbiB p.Thr374Lys fbiB_p.Thr374Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 111.334370311011 1 245.5 609 False False 0 0 111.334370311011 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Delamanid fbiB p.Trp418Ser fbiB_p.Trp418Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiB p.Tyr183Cys fbiB_p.Tyr183Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fbiB p.Val17Ala fbiB_p.Val17Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 249 11390 0 0 0.0147055780339792 0.999648938037563 0.999101388115099 0.99990433941184 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 534 609 False False 0 0 69.5552063788676 0 0 0.0147055780339792 0.999648938037563 0.999101388115099 0.99990433941184 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 58 3) Uncertain significance No change no 1 +Delamanid fbiB p.Val17fs fbiB_p.Val17fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 542 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim New AwRI no 5 +Delamanid fbiB p.Val17Ile fbiB_p.Val17Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fbiB p.Val192Ile fbiB_p.Val192Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 543 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fbiB p.Val214Leu fbiB_p.Val214Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiB p.Val217_Gly378del fbiB_p.Val217_Gly378del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 248 11394 0.00401606425702811 0.000101672774685082 0.0221717421523238 1 0.999676296088332 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 1.17330688615895 Inf 0.0213862406596237 17.5 609 False False Inf 1.17330688615895 Inf 0.00401606425702811 0.000101672774685082 0.0221717421523238 1 0.999676296088332 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 53 506 0.0185185185185185 0.00046873840381796 0.0989151595078512 1 0.992736233998274 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.240265883472405 Inf 0.0964285714285713 5 83 False False 0 0 0 0 0 0 0 Inf 0.240265883472405 Inf 0.0185185185185185 0.00046873840381796 0.0989151595078512 1 0.992736233998274 1 NA 3) Uncertain significance New Uncertain no 0 +Delamanid fbiB p.Val348Ile fbiB_p.Val348Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 244.200965863688 1 47 609 False False 0 0 111.334370311011 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 12 3) Uncertain significance No change no 1 +Delamanid fbiB p.Val416Ile fbiB_p.Val416Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 1736.06792348613 1 245.5 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 10 3) Uncertain significance No change no 1 +Delamanid fbiC c.-100C>G fbiC_c.-100C>G 1 upstream_gene_variant 1302831 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiC c.-100C>T fbiC_c.-100C>T 1 upstream_gene_variant 1302831 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 476 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiC c.1023C>T fbiC_c.1023C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 244.222407132781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.1065C>T fbiC_c.1065C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.-10G>A fbiC_c.-10G>A 1 upstream_gene_variant 1302921 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 489 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fbiC c.-110G>A fbiC_c.-110G>A 1 upstream_gene_variant 1302821 1 3 0 3 0 4 249 11390 0 0 0.0147055780339792 0.999648938037563 0.999101388115099 0.99990433941184 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 111.324479323847 1 245.5 609 False False 0 0 69.5552063788676 0 0 0.0147055780339792 0.999648938037563 0.999101388115099 0.99990433941184 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 54 504 0 0 0.0660315142444217 0.996047430830039 0.985795485070057 0.999520966589986 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 50.236220806896 1 34 83 False False 0 0 0 0 0 0 0 0 0 50.236220806896 0 0 0.0660315142444217 0.996047430830039 0.985795485070057 0.999520966589986 83 3) Uncertain significance No change no 1 +Delamanid fbiC c.-111C>T fbiC_c.-111C>T 1 upstream_gene_variant 1302820 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Delamanid fbiC c.-113G>A fbiC_c.-113G>A 1 upstream_gene_variant 1302818 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 501 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fbiC c.-113G>C fbiC_c.-113G>C 1 upstream_gene_variant 1302818 1 30 0 30 0 30 249 11364 0 0 0.0147055780339792 0.997367035281727 0.996243395376242 0.998222866295591 0 0 0.115703308222027 0 0 0.115703308222027 0 0 0.115703308222027 0 0 6.01245733958157 1 47 609 False False 0 0 6.01245733958157 0 0 0.0147055780339792 0.997367035281727 0.996243395376242 0.998222866295591 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 33 3) Uncertain significance No change no 1 +Delamanid fbiC c.1143C>T fbiC_c.1143C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 6 249 11388 0 0 0.0147055780339792 0.999473407056345 0.998854183895649 0.999806725936475 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 39.0576580619631 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.-114C>T fbiC_c.-114C>T 1 upstream_gene_variant 1302817 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fbiC c.1174C>T fbiC_c.1174C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.117G>A fbiC_c.117G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.334370311011 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.-11G>A fbiC_c.-11G>A 1 upstream_gene_variant 1302920 1 0 0 0 0 66 249 11328 0 0 0.0147055780339792 0.9942074776198 0.992636307144157 0.995517314816434 0 0 0.0543588471701219 NA NA NA 0 0 0.0543588471701219 NA NA NA NA 511 609 False False 0 0 2.6344389675365 0 0 0.0147055780339792 0.9942074776198 0.992636307144157 0.995517314816434 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 66 83 False False 0 0 0 0 0 0 0 0 0 363.375224416517 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 56 3) Uncertain significance No change no 1 +Delamanid fbiC c.1248G>T fbiC_c.1248G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.1272G>A fbiC_c.1272G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.1314C>T fbiC_c.1314C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.1323G>T fbiC_c.1323G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 244.222407132781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 69 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.1335C>T fbiC_c.1335C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 9 249 11385 0 0 0.0147055780339792 0.999210110584518 0.998501075795816 0.999638750670416 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 23.2953648317795 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 28 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.1380C>T fbiC_c.1380C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 363.375224416517 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.1383A>C fbiC_c.1383A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.1392C>T fbiC_c.1392C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 0 NA NA NA 1 0 248 11394 0.00401606425702811 0.000101672774685082 0.0221717421523238 1 0.999676296088332 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.17330688615895 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 NA NA NA 1 0 53 506 0.0185185185185185 0.00046873840381796 0.0989151595078512 1 0.992736233998274 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.240265883472405 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.-14_-13insA fbiC_c.-14_-13insA 1 upstream_gene_variant 1302917 1 10 0 10 0 11 249 11383 0 0 0.0147055780339792 0.9990345796033 0.99827325433968 0.99951797022408 0 0 0.284914152918154 0 0 0.30849710781876 0 0 0.284914152918154 0 0 20.5095287745738 1 439.5 609 False False 0 0 18.324112815918 0 0 0.0147055780339792 0.9990345796033 0.99827325433968 0.99951797022408 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 58 3) Uncertain significance No change no 1 +Delamanid fbiC c.1413T>G fbiC_c.1413T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 0 NA NA NA 1 12 248 11382 0.00401606425702811 0.000101672774685082 0.0221717421523238 0.99894681411269 0.998161019670976 0.999455688821616 0.0769230769230769 0.00194562849734675 0.360297435267877 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.82459677419354 0.0891139566851954 26.009176452134 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.141G>A fbiC_c.141G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.1425G>A fbiC_c.1425G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.1467A>G fbiC_c.1467A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.1470C>T fbiC_c.1470C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.1518C>T fbiC_c.1518C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.1521C>T fbiC_c.1521C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 244.222407132781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.1533C>T fbiC_c.1533C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 244.222407132781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.1545G>A fbiC_c.1545G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.1572G>A fbiC_c.1572G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.1573C>T fbiC_c.1573C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.-15G>T fbiC_c.-15G>T 1 upstream_gene_variant 1302916 1 2 0 2 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 244.222407132781 1 245.5 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiC c.1635C>T fbiC_c.1635C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 249 11389 0 0 0.0147055780339792 0.999561172546954 0.998976222751812 0.99985749905819 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 50.1343664673437 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 14 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.165G>A fbiC_c.165G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 184 248 11210 0.00401606425702811 0.000101672774685082 0.0221717421523238 0.983851149727927 0.981365195045858 0.986085203700661 0.0054054054054054 0.000136843652184451 0.0297474941120461 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.245660939691444 0.00616503787649707 1.39885949131808 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 54 504 0 0 0.0660315142444217 0.996047430830039 0.985795485070057 0.999520966589986 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 50.236220806896 NA NA NA NA NA NA 692 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.1674C>T fbiC_c.1674C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.1680C>T fbiC_c.1680C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 16 249 11378 0 0 0.0147055780339792 0.998595752150254 0.997720588509296 0.99919714469723 0 0 0.205907214207822 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 11.9219739008791 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 363.375224416517 NA NA NA NA NA NA 76 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.1725C>T fbiC_c.1725C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.172C>T fbiC_c.172C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.1743C>T fbiC_c.1743C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 244.222407132781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.1773C>T fbiC_c.1773C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 6 249 11388 0 0 0.0147055780339792 0.999473407056345 0.998854183895649 0.999806725936475 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 39.0576580619631 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 15 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.1794A>G fbiC_c.1794A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.1842C>T fbiC_c.1842C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.186C>T fbiC_c.186C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 12 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.-18C>T fbiC_c.-18C>T 1 upstream_gene_variant 1302913 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiC c.18T>G fbiC_c.18T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.1902C>G fbiC_c.1902C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.1902C>T fbiC_c.1902C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.1923C>G fbiC_c.1923C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.195G>A fbiC_c.195G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 244.222407132781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.1989C>T fbiC_c.1989C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.1995G>A fbiC_c.1995G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.-1C>T fbiC_c.-1C>T 1 upstream_gene_variant 1302930 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fbiC c.201T>C fbiC_c.201T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.2073C>T fbiC_c.2073C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.2088C>T fbiC_c.2088C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.2104C>T fbiC_c.2104C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.2130C>T fbiC_c.2130C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.2142C>T fbiC_c.2142C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.2176C>T fbiC_c.2176C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.334370311011 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.2181C>T fbiC_c.2181C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.2196T>C fbiC_c.2196T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.2229G>A fbiC_c.2229G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.222C>T fbiC_c.222C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.2235G>A fbiC_c.2235G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 248 11394 0.00401606425702811 0.000101672774685082 0.0221717421523238 1 0.999676296088332 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.17330688615895 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.2238C>T fbiC_c.2238C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.2250G>A fbiC_c.2250G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 7 249 11387 0 0 0.0147055780339792 0.999385641565736 0.998734599099098 0.99975296150752 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.8900809629541 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 16 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.2259G>A fbiC_c.2259G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.231G>A fbiC_c.231G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 244.222407132781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.237C>T fbiC_c.237C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.2409C>T fbiC_c.2409C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.2424C>T fbiC_c.2424C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.2427C>G fbiC_c.2427C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 7 248 11387 0.00401606425702811 0.000101672774685082 0.0221717421523238 0.999385641565736 0.998734599099098 0.99975296150752 0.125 0.0031597235312519 0.526509670875206 NA NA NA NA NA NA NA NA NA NA NA NA False False 6.55933179723502 0.144961668339134 51.390023884054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 363.375224416517 NA NA NA NA NA NA 11 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.2433G>A fbiC_c.2433G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.2487C>T fbiC_c.2487C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 244.222407132781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.24G>A fbiC_c.24G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 27 249 11367 0 0 0.0147055780339792 0.997630331753554 0.996554115949967 0.998437810810048 0 0 0.127702867615432 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 6.72931596197612 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 46 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.2517C>T fbiC_c.2517C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.2526C>G fbiC_c.2526C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.2532G>T fbiC_c.2532G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.334370311011 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 363.375224416517 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.321C>T fbiC_c.321C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.-32A>G fbiC_c.-32A>G 1 upstream_gene_variant 1302899 1 5 0 5 0 43 249 11351 0 0 0.0147055780339792 0.996226083903809 0.994919889779425 0.997267492435784 0 0 0.0822111211541385 0 0 0.521823750104981 0 0 0.0822111211541385 0 0 49.9669251265805 1 47 609 False False 0 0 4.11283634563004 0 0 0.0147055780339792 0.996226083903809 0.994919889779425 0.997267492435784 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 5 54 501 0 0 0.0660315142444217 0.990118577075098 0.977091674593924 0.996783963293044 0 0 0.521823750104981 0 0 0.975 0 0 0.521823750104981 0 0 360.518874276224 1 34 83 False False 0 0 0 0 0 0 0 0 0 10.3667075351405 0 0 0.0660315142444217 0.990118577075098 0.977091674593924 0.996783963293044 437 3) Uncertain significance No change no 1 +Delamanid fbiC c.-33G>A fbiC_c.-33G>A 1 upstream_gene_variant 1302898 1 1 0 1 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 1736.06792348613 1 245.5 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Delamanid fbiC c.34C>T fbiC_c.34C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.396C>T fbiC_c.396C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 23 249 11371 0 0 0.0147055780339792 0.99798139371599 0.99697262970051 0.998719959807472 0 0 0.148185128915224 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.99673004764782 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 65 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.-44T>C fbiC_c.-44T>C 1 upstream_gene_variant 1302887 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiC c.-46G>C fbiC_c.-46G>C 1 upstream_gene_variant 1302885 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 475 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Delamanid fbiC c.-48C>T fbiC_c.-48C>T 1 upstream_gene_variant 1302883 1 1 0 1 0 4 249 11390 0 0 0.0147055780339792 0.999648938037563 0.999101388115099 0.99990433941184 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 1735.77142857148 1 245.5 609 False False 0 0 69.5552063788676 0 0 0.0147055780339792 0.999648938037563 0.999101388115099 0.99990433941184 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 12 3) Uncertain significance No change no 1 +Delamanid fbiC c.495G>A fbiC_c.495G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.498C>A fbiC_c.498C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 249 11390 0 0 0.0147055780339792 0.999648938037563 0.999101388115099 0.99990433941184 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 69.5552063788676 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 14 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.498C>T fbiC_c.498C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 244.222407132781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.-4C>T fbiC_c.-4C>T 1 upstream_gene_variant 1302927 1 7 0 7 0 7 249 11387 0 0 0.0147055780339792 0.999385641565736 0.998734599099098 0.99975296150752 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 31.8900809629541 1 245.5 609 False False 0 0 31.8900809629541 0 0 0.0147055780339792 0.999385641565736 0.998734599099098 0.99975296150752 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 54 504 0 0 0.0660315142444217 0.996047430830039 0.985795485070057 0.999520966589986 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 50.236220806896 1 34 83 False False 0 0 0 0 0 0 0 0 0 50.236220806896 0 0 0.0660315142444217 0.996047430830039 0.985795485070057 0.999520966589986 5 3) Uncertain significance No change no 1 +Delamanid fbiC c.519C>T fbiC_c.519C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.525C>G fbiC_c.525C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.546G>C fbiC_c.546G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 244.222407132781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 363.375224416517 NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.57C>A fbiC_c.57C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.-58A>C fbiC_c.-58A>C 1 upstream_gene_variant 1302873 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Delamanid fbiC c.624G>T fbiC_c.624G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.334370311011 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.690C>T fbiC_c.690C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 244.222407132781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.714G>A fbiC_c.714G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.750G>A fbiC_c.750G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.-76A>G fbiC_c.-76A>G 1 upstream_gene_variant 1302855 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Delamanid fbiC c.771C>T fbiC_c.771C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 244.222407132781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.-77T>C fbiC_c.-77T>C 1 upstream_gene_variant 1302854 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Delamanid fbiC c.810C>T fbiC_c.810C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.813C>T fbiC_c.813C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.819G>A fbiC_c.819G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.819G>T fbiC_c.819G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.-81C>A fbiC_c.-81C>A 1 upstream_gene_variant 1302850 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiC c.822A>G fbiC_c.822A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.861C>T fbiC_c.861C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.-87C>T fbiC_c.-87C>T 1 upstream_gene_variant 1302844 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Delamanid fbiC c.-89_-88insACTGTTGCGC fbiC_c.-89_-88insACTGTTGCGC 1 upstream_gene_variant 1302842 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fbiC c.-90C>T fbiC_c.-90C>T 1 upstream_gene_variant 1302841 1 2 0 2 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 244.222407132781 1 245.5 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fbiC c.939T>C fbiC_c.939T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC c.967C>T fbiC_c.967C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 35 249 11359 0 0 0.0147055780339792 0.996928207828681 0.995730445513544 0.997859479868132 0 0 0.100032435572105 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.10690069444704 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 22 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fbiC LoF fbiC_LoF 1 LoF (see "Genomic_coordinates" sheet) 1 4 0 4 3 4 246 11390 0.0120481927710843 0.00249155218688723 0.0348042232340379 0.999648938037563 0.999101388115099 0.99990433941184 0.428571428571428 0.0989882784425078 0.815948432359917 0 0 0.602364635616474 0 0 0.602364635616474 0 0 70.405921470528 1 245.5 609 False False 34.7256097560975 5.05123661468078 205.761777546558 0 0 0.0148835731382165 0.999648938037563 0.999101388115099 0.99990433941184 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 2 2 52 504 0.037037037037037 0.00451725629446049 0.127471772230947 0.996047430830039 0.985795485070057 0.999520966589986 0.5 0.067585986488543 0.932414013511457 0 0 0.841886116991581 0 0 0.841886116991581 0 0 52.1867558830542 1 11 83 False False 0 0 0 0 0 0 0 9.69230769230769 0.683628473999945 135.253241194427 0 0 0.0684822087033195 0.996047430830039 0.985795485070057 0.999520966589986 NA Marker of R Selection evidence 2) Assoc w R - Interim Confers DLM-PMD cross-resistance New AwRI yes Selection R 5 +Delamanid fbiC p.Ala11Val fbiC_p.Ala11Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 111.334370311011 1 245.5 609 False False 0 0 111.334370311011 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Delamanid fbiC p.Ala143Val fbiC_p.Ala143Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fbiC p.Ala333Val fbiC_p.Ala333Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 7 249 11387 0 0 0.0147055780339792 0.999385641565736 0.998734599099098 0.99975296150752 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 39.0541714059558 1 245.5 609 False False 0 0 31.8900809629541 0 0 0.0147055780339792 0.999385641565736 0.998734599099098 0.99975296150752 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 14 3) Uncertain significance No change no 1 +Delamanid fbiC p.Ala349Val fbiC_p.Ala349Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 499 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 3) Uncertain significance No change no 1 +Delamanid fbiC p.Ala378Glu fbiC_p.Ala378Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fbiC p.Ala404Pro fbiC_p.Ala404Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 244.222407132781 1 245.5 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Delamanid fbiC p.Ala418Glu fbiC_p.Ala418Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fbiC p.Ala45Thr fbiC_p.Ala45Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fbiC p.Ala469Pro fbiC_p.Ala469Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiC p.Ala487fs fbiC_p.Ala487fs 1 frameshift (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 248 11394 0.00401606425702811 0.000101672774685082 0.0221717421523238 1 0.999676296088332 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 1.17330688615895 Inf 0.0213862406596237 17.5 609 False False Inf 1.17330688615895 Inf 0.00401606425702811 0.000101672774685082 0.0221717421523238 1 0.999676296088332 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim New AwRI no 5 +Delamanid fbiC p.Ala505Thr fbiC_p.Ala505Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 30 0 30 0 36 249 11358 0 0 0.0147055780339792 0.996840442338072 0.99562849775438 0.997786133292925 0 0 0.0973937559144919 0 0 0.115703308222027 0 0 0.0973937559144919 0 0 6.00928025282183 1 245.5 609 False False 0 0 4.95721187020393 0 0 0.0147055780339792 0.996840442338072 0.99562849775438 0.997786133292925 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 102 3) Uncertain significance No change no 1 +Delamanid fbiC p.Ala524Gly fbiC_p.Ala524Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 1 7 1 7 248 11387 0.00401606425702811 0.000101672774685082 0.0221717421523238 0.999385641565736 0.998734599099098 0.99975296150752 0.125 0.0031597235312519 0.526509670875206 0.125 0.0031597235312519 0.526509670875206 0.125 0.0031597235312519 0.526509670875206 6.55933179723502 0.144961668339134 51.390023884054 0.158861121824517 37 609 False False 6.55933179723502 0.144961668339134 51.390023884054 0.00401606425702811 0.000101672774685082 0.0221717421523238 0.999385641565736 0.998734599099098 0.99975296150752 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 0 0 0.975 0 0 0.975 0 0 363.375224416517 1 34 83 False False 0 0 0 0 0 0 0 0 0 363.375224416517 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 11 3) Uncertain significance No change no 1 +Delamanid fbiC p.Ala574Val fbiC_p.Ala574Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Delamanid fbiC p.Ala594Ser fbiC_p.Ala594Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 1 2 248 11392 0.00401606425702811 0.000101672774685082 0.0221717421523238 0.999824469018782 0.99936606710312 0.999978741676894 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 22.9677419354838 0.387752230133854 440.62889055685 0.0628016676317913 28.5 609 False False 22.9677419354838 0.387752230133854 440.62889055685 0.00401606425702811 0.000101672774685082 0.0221717421523238 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiC p.Ala620Thr fbiC_p.Ala620Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 249 11390 0 0 0.0147055780339792 0.999648938037563 0.999101388115099 0.99990433941184 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 69.5552063788676 1 245.5 609 False False 0 0 69.5552063788676 0 0 0.0147055780339792 0.999648938037563 0.999101388115099 0.99990433941184 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Delamanid fbiC p.Ala623Val fbiC_p.Ala623Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 248 11394 0.00401606425702811 0.000101672774685082 0.0221717421523238 1 0.999676296088332 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 1.17330688615895 Inf 0.0213862406596237 17.5 609 False False Inf 1.17330688615895 Inf 0.00401606425702811 0.000101672774685082 0.0221717421523238 1 0.999676296088332 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fbiC p.Ala639fs fbiC_p.Ala639fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim New AwRI no 5 +Delamanid fbiC p.Ala63Thr fbiC_p.Ala63Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fbiC p.Ala659Val fbiC_p.Ala659Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fbiC p.Ala73Ser fbiC_p.Ala73Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Delamanid fbiC p.Ala754Val fbiC_p.Ala754Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 111.334370311011 1 245.5 609 False False 0 0 111.334370311011 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fbiC p.Ala852Thr fbiC_p.Ala852Thr 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 248 11394 0.00401606425702811 0.000101672774685082 0.0221717421523238 1 0.999676296088332 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 1.17330688615895 Inf 0.0213862406596237 17.5 609 False False Inf 1.17330688615895 Inf 0.00401606425702811 0.000101672774685082 0.0221717421523238 1 0.999676296088332 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Delamanid fbiC p.Ala852Val fbiC_p.Ala852Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 3) Uncertain significance No change no 1 +Delamanid fbiC p.Ala855fs fbiC_p.Ala855fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 244.222407132781 1 245.5 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 54 504 0 0 0.0660315142444217 0.996047430830039 0.985795485070057 0.999520966589986 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 50.236220806896 1 34 83 False False 0 0 0 0 0 0 0 0 0 50.236220806896 0 0 0.0660315142444217 0.996047430830039 0.985795485070057 0.999520966589986 130 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim New AwRI no 5 +Delamanid fbiC p.Ala856fs fbiC_p.Ala856fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim UP from Uncertain to AwRI no 4 +Delamanid fbiC p.Arg134Leu fbiC_p.Arg134Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 508 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Delamanid fbiC p.Arg243Gly fbiC_p.Arg243Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 478 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiC p.Arg330Cys fbiC_p.Arg330Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 498 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiC p.Arg426Cys fbiC_p.Arg426Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fbiC p.Arg536Leu fbiC_p.Arg536Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 0 0 0.975 0 0 0.975 0 0 363.375224416517 1 34 83 False False 0 0 0 0 0 0 0 0 0 363.375224416517 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 NA 3) Uncertain significance New Uncertain no 0 +Delamanid fbiC p.Arg64Gln fbiC_p.Arg64Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fbiC p.Arg66Ser fbiC_p.Arg66Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 486 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fbiC p.Arg727Cys fbiC_p.Arg727Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiC p.Arg7Leu fbiC_p.Arg7Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 493 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fbiC p.Asn549Asp fbiC_p.Asn549Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fbiC p.Asp100Glu fbiC_p.Asp100Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 15 0 15 0 16 249 11378 0 0 0.0147055780339792 0.998595752150254 0.997720588509296 0.99919714469723 0 0 0.205907214207822 0 0 0.218019360910534 0 0 0.205907214207822 0 0 12.8184967107212 1 47 609 False False 0 0 11.9219739008791 0 0 0.0147055780339792 0.998595752150254 0.997720588509296 0.99919714469723 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiC p.Asp130Glu fbiC_p.Asp130Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 479 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiC p.Asp168Glu fbiC_p.Asp168Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 496 609 False False 0 0 111.334370311011 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Delamanid fbiC p.Asp235Gly fbiC_p.Asp235Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 506 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiC p.Asp272Gly fbiC_p.Asp272Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 249 11390 0 0 0.0147055780339792 0.999648938037563 0.999101388115099 0.99990433941184 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 491 609 False False 0 0 69.5552063788676 0 0 0.0147055780339792 0.999648938037563 0.999101388115099 0.99990433941184 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Delamanid fbiC p.Asp313Gly fbiC_p.Asp313Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 480 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fbiC p.Asp352Gly fbiC_p.Asp352Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiC p.Asp375Asn fbiC_p.Asp375Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 7 249 11387 0 0 0.0147055780339792 0.999385641565736 0.998734599099098 0.99975296150752 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 39.0541714059558 1 245.5 609 False False 0 0 31.8900809629541 0 0 0.0147055780339792 0.999385641565736 0.998734599099098 0.99975296150752 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiC p.Asp427His fbiC_p.Asp427His 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 111.334370311011 1 245.5 609 False False 0 0 111.334370311011 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiC p.Asp454Asn fbiC_p.Asp454Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 487 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fbiC p.Asp472Ala fbiC_p.Asp472Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fbiC p.Asp521Gly fbiC_p.Asp521Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 500 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiC p.Asp542Glu fbiC_p.Asp542Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 244.222407132781 1 245.5 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fbiC p.Asp616Gly fbiC_p.Asp616Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 249 11389 0 0 0.0147055780339792 0.999561172546954 0.998976222751812 0.99985749905819 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 50.1343664673437 1 245.5 609 False False 0 0 50.1343664673437 0 0 0.0147055780339792 0.999561172546954 0.998976222751812 0.99985749905819 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 0 0 0.975 0 0 0.975 0 0 363.375224416517 1 34 83 False False 0 0 0 0 0 0 0 0 0 363.375224416517 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 NA 3) Uncertain significance No change no 1 +Delamanid fbiC p.Gln117Pro fbiC_p.Gln117Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fbiC p.Glu265Asp fbiC_p.Glu265Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fbiC p.Glu299Val fbiC_p.Glu299Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fbiC p.Glu376Asp fbiC_p.Glu376Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 497 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 62 83 False False 0 0 0 0 0 0 0 0 0 363.375224416517 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 NA 3) Uncertain significance New Uncertain no 0 +Delamanid fbiC p.Glu526Lys fbiC_p.Glu526Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiC p.Glu54Gly fbiC_p.Glu54Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiC p.Glu598Asp fbiC_p.Glu598Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 248 11394 0.00401606425702811 0.000101672774685082 0.0221717421523238 1 0.999676296088332 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 484 609 False False Inf 1.17330688615895 Inf 0 0 0.0147644348125545 1 0.999676296088332 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiC p.Glu738Gly fbiC_p.Glu738Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 0 0 0.975 0 0 0.975 0 0 363.375224416517 1 34 83 False False 0 0 0 0 0 0 0 0 0 363.375224416517 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 NA 3) Uncertain significance New Uncertain no 0 +Delamanid fbiC p.Glu801Gly fbiC_p.Glu801Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiC p.Glu832Gly fbiC_p.Glu832Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiC p.Gly135Ser fbiC_p.Gly135Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiC p.Gly262Asp fbiC_p.Gly262Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 495 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fbiC p.Gly285Glu fbiC_p.Gly285Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 483 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiC p.Gly340Asp fbiC_p.Gly340Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiC p.Gly385Asp fbiC_p.Gly385Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiC p.Gly385Cys fbiC_p.Gly385Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiC p.Gly508Ser fbiC_p.Gly508Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 111.334370311011 1 245.5 609 False False 0 0 111.334370311011 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 14 3) Uncertain significance No change no 1 +Delamanid fbiC p.Gly522Arg fbiC_p.Gly522Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 249 11390 0 0 0.0147055780339792 0.999648938037563 0.999101388115099 0.99990433941184 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 69.5552063788676 1 245.5 609 False False 0 0 69.5552063788676 0 0 0.0147055780339792 0.999648938037563 0.999101388115099 0.99990433941184 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiC p.Gly683Ala fbiC_p.Gly683Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 509 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiC p.Gly711Ala fbiC_p.Gly711Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fbiC p.Gly839Ala fbiC_p.Gly839Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 249 11389 0 0 0.0147055780339792 0.999561172546954 0.998976222751812 0.99985749905819 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 50.1343664673437 1 245.5 609 False False 0 0 50.1343664673437 0 0 0.0147055780339792 0.999561172546954 0.998976222751812 0.99985749905819 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 3) Uncertain significance No change no 1 +Delamanid fbiC p.Gly839Asp fbiC_p.Gly839Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 249 11390 0 0 0.0147055780339792 0.999648938037563 0.999101388115099 0.99990433941184 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 69.5552063788676 1 245.5 609 False False 0 0 69.5552063788676 0 0 0.0147055780339792 0.999648938037563 0.999101388115099 0.99990433941184 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Delamanid fbiC p.Gly839Ser fbiC_p.Gly839Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 485 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Delamanid fbiC p.His103Arg fbiC_p.His103Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 244.222407132781 1 245.5 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fbiC p.His300Tyr fbiC_p.His300Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fbiC p.His592Arg fbiC_p.His592Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 507 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiC p.Ile406Phe fbiC_p.Ile406Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 244.222407132781 1 245.5 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fbiC p.Ile453Val fbiC_p.Ile453Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 244.222407132781 1 245.5 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiC p.Ile491Val fbiC_p.Ile491Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fbiC p.Ile693Val fbiC_p.Ile693Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 504 609 False False 0 0 111.334370311011 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance No change no 1 +Delamanid fbiC p.Ile781Val fbiC_p.Ile781Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 512 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiC p.Ile816Met fbiC_p.Ile816Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiC p.Leu114Arg fbiC_p.Leu114Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 244.222407132781 1 245.5 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Delamanid fbiC p.Leu162Val fbiC_p.Leu162Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fbiC p.Leu517Ile fbiC_p.Leu517Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiC p.Leu647Arg fbiC_p.Leu647Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 490 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiC p.Lys113Thr fbiC_p.Lys113Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 1736.06792348613 1 245.5 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiC p.Lys622Arg fbiC_p.Lys622Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 494 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiC p.Lys682Arg fbiC_p.Lys682Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fbiC p.Met196Val fbiC_p.Met196Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 510 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 65 83 False False 0 0 0 0 0 0 0 0 0 363.375224416517 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 NA 3) Uncertain significance New Uncertain no 0 +Delamanid fbiC p.Met211Ile fbiC_p.Met211Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 481 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Delamanid fbiC p.Met628Ile fbiC_p.Met628Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fbiC p.Met709Ile fbiC_p.Met709Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 244.222407132781 1 245.5 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiC p.Met812Ile fbiC_p.Met812Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 248 11394 0.00401606425702811 0.000101672774685082 0.0221717421523238 1 0.999676296088332 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 1.17330688615895 Inf 0.0213862406596237 17.5 609 False False Inf 1.17330688615895 Inf 0.00401606425702811 0.000101672774685082 0.0221717421523238 1 0.999676296088332 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fbiC p.Phe306Leu fbiC_p.Phe306Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Delamanid fbiC p.Phe470Leu fbiC_p.Phe470Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 488 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 61 83 False False 0 0 0 0 0 0 0 0 0 363.375224416517 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 NA 3) Uncertain significance New Uncertain no 0 +Delamanid fbiC p.Phe470Val fbiC_p.Phe470Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiC p.Pro125His fbiC_p.Pro125His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiC p.Pro18Leu fbiC_p.Pro18Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance New Uncertain no 0 +Delamanid fbiC p.Pro234Leu fbiC_p.Pro234Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fbiC p.Pro334Ala fbiC_p.Pro334Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 513 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiC p.Pro359Ser fbiC_p.Pro359Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiC p.Pro362fs fbiC_p.Pro362fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 248 11394 0.00401606425702811 0.000101672774685082 0.0221717421523238 1 0.999676296088332 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 505 609 False False Inf 1.17330688615895 Inf 0 0 0.0147644348125545 1 0.999676296088332 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 53 506 0.0185185185185185 0.00046873840381796 0.0989151595078512 1 0.992736233998274 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 64 83 False False 0 0 0 0 0 0 0 Inf 0.240265883472405 Inf 0 0 0.0672345463063011 1 0.992736233998274 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim New AwRI no 5 +Delamanid fbiC p.Pro420Leu fbiC_p.Pro420Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance No change no 1 +Delamanid fbiC p.Pro420Ser fbiC_p.Pro420Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Delamanid fbiC p.Pro438Leu fbiC_p.Pro438Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Delamanid fbiC p.Pro761Leu fbiC_p.Pro761Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 244.222407132781 1 245.5 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fbiC p.Ser172Cys fbiC_p.Ser172Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 244.200965863688 1 47 609 False False 0 0 111.334370311011 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiC p.Ser219Ala fbiC_p.Ser219Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiC p.Ser443fs fbiC_p.Ser443fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 248 11394 0.00401606425702811 0.000101672774685082 0.0221717421523238 1 0.999676296088332 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 503 609 False False Inf 1.17330688615895 Inf 0 0 0.0147644348125545 1 0.999676296088332 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 53 506 0.0185185185185185 0.00046873840381796 0.0989151595078512 1 0.992736233998274 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 63 83 False False 0 0 0 0 0 0 0 Inf 0.240265883472405 Inf 0 0 0.0672345463063011 1 0.992736233998274 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim New AwRI no 5 +Delamanid fbiC p.Ser645Gly fbiC_p.Ser645Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 492 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiC p.Ser762Asn fbiC_p.Ser762Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 111.334370311011 1 245.5 609 False False 0 0 111.334370311011 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 12 3) Uncertain significance No change no 1 +Delamanid fbiC p.Ter857Trpext*? fbiC_p.Ter857Trpext*? 1 stop_lost (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 502 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Delamanid fbiC p.Thr273Ala fbiC_p.Thr273Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 20 0 20 0 23 249 11371 0 0 0.0147055780339792 0.99798139371599 0.99697262970051 0.998719959807472 0 0 0.148185128915224 0 0 0.168433470983085 0 0 0.148185128915224 0 0 9.31405424581183 1 245.5 609 False False 0 0 7.99673004764782 0 0 0.0147055780339792 0.99798139371599 0.99697262970051 0.998719959807472 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 0 0 0.975 0 0 0.975 0 0 363.375224416517 1 34 83 False False 0 0 0 0 0 0 0 0 0 363.375224416517 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 138 3) Uncertain significance No change no 1 +Delamanid fbiC p.Thr663Asn fbiC_p.Thr663Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Delamanid fbiC p.Thr687Met fbiC_p.Thr687Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 477 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Delamanid fbiC p.Thr707Met fbiC_p.Thr707Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fbiC p.Trp405Cys fbiC_p.Trp405Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 482 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiC p.Trp678Gly fbiC_p.Trp678Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 157 1 156 1 159 248 11235 0.00401606425702811 0.000101672774685082 0.0221717421523238 0.986045286993154 0.983718925435488 0.988118153606828 0.00625 0.000158223781198821 0.0343293296841414 0.00636942675159235 0.000161246921784249 0.0349757750367045 0.00625 0.000158223781198821 0.0343293296841414 0.290400124069478 0.00728013224787918 1.65719596769104 0.267466173984754 40 609 False False 0.284920876445526 0.00714368952646496 1.62543157024838 0.00401606425702811 0.000101672774685082 0.0221717421523238 0.986045286993154 0.983718925435488 0.988118153606828 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 54 504 0 0 0.0660315142444217 0.996047430830039 0.985795485070057 0.999520966589986 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 50.236220806896 1 34 83 False False 0 0 0 0 0 0 0 0 0 50.236220806896 0 0 0.0660315142444217 0.996047430830039 0.985795485070057 0.999520966589986 308 3) Uncertain significance No change no 1 +Delamanid fbiC p.Val365Ile fbiC_p.Val365Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiC p.Val37Ala fbiC_p.Val37Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Delamanid fbiC p.Val41Met fbiC_p.Val41Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 249 11389 0 0 0.0147055780339792 0.999561172546954 0.998976222751812 0.99985749905819 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 69.5491050245269 1 245.5 609 False False 0 0 50.1343664673437 0 0 0.0147055780339792 0.999561172546954 0.998976222751812 0.99985749905819 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 54 504 0 0 0.0660315142444217 0.996047430830039 0.985795485070057 0.999520966589986 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 50.236220806896 1 34 83 False False 0 0 0 0 0 0 0 0 0 50.236220806896 0 0 0.0660315142444217 0.996047430830039 0.985795485070057 0.999520966589986 11 3) Uncertain significance No change no 1 +Delamanid fbiC p.Val581Leu fbiC_p.Val581Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 1 7 1 7 248 11387 0.00401606425702811 0.000101672774685082 0.0221717421523238 0.999385641565736 0.998734599099098 0.99975296150752 0.125 0.0031597235312519 0.526509670875206 0.125 0.0031597235312519 0.526509670875206 0.125 0.0031597235312519 0.526509670875206 6.55933179723502 0.144961668339134 51.390023884054 0.158861121824517 37 609 False False 6.55933179723502 0.144961668339134 51.390023884054 0.00401606425702811 0.000101672774685082 0.0221717421523238 0.999385641565736 0.998734599099098 0.99975296150752 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 35 3) Uncertain significance No change no 1 +Delamanid fbiC p.Val621Ile fbiC_p.Val621Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Delamanid fbiC p.Val713Leu fbiC_p.Val713Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 1 3 1 3 248 11391 0.00401606425702811 0.000101672774685082 0.0221717421523238 0.999736703528172 0.999230730695071 0.999945698645904 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 15.3104838709677 0.290482936930346 191.361367823419 0.0828499824736885 30.5 609 False False 15.3104838709677 0.290482936930346 191.361367823419 0.00401606425702811 0.000101672774685082 0.0221717421523238 0.999736703528172 0.999230730695071 0.999945698645904 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiC p.Val725Ala fbiC_p.Val725Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiC p.Val745Met fbiC_p.Val745Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fbiC p.Val94Ala fbiC_p.Val94Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fgd1 c.1000C>A fgd1_c.1000C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fgd1 c.1002A>C fgd1_c.1002A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fgd1 c.135C>T fgd1_c.135C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 244.222407132781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fgd1 c.138C>T fgd1_c.138C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fgd1 c.153C>T fgd1_c.153C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 244.222407132781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fgd1 c.18A>C fgd1_c.18A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 363.375224416517 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fgd1 c.195C>T fgd1_c.195C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fgd1 c.-20C>T fgd1_c.-20C>T 1 upstream_gene_variant 490763 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 532 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fgd1 c.228C>T fgd1_c.228C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.334370311011 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 363.375224416517 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fgd1 c.246C>T fgd1_c.246C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 249 11390 0 0 0.0147055780339792 0.999648938037563 0.999101388115099 0.99990433941184 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 69.5552063788676 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fgd1 c.255C>T fgd1_c.255C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fgd1 c.-27T>G fgd1_c.-27T>G 1 upstream_gene_variant 490756 1 16 0 16 0 16 249 11378 0 0 0.0147055780339792 0.998595752150254 0.997720588509296 0.99919714469723 0 0 0.205907214207822 0 0 0.205907214207822 0 0 0.205907214207822 0 0 11.9219739008791 1 245.5 609 False False 0 0 11.9219739008791 0 0 0.0147055780339792 0.998595752150254 0.997720588509296 0.99919714469723 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 54 503 0 0 0.0660315142444217 0.994071146245059 0.982771870681216 0.998775654961114 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 22.9227911903789 1 34 83 False False 0 0 0 0 0 0 0 0 0 22.9227911903789 0 0 0.0660315142444217 0.994071146245059 0.982771870681216 0.998775654961114 29 3) Uncertain significance New Uncertain no 0 +Delamanid fgd1 c.286C>T fgd1_c.286C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fgd1 c.291C>T fgd1_c.291C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fgd1 c.297C>T fgd1_c.297C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fgd1 c.318C>T fgd1_c.318C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 244.222407132781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fgd1 c.-31C>G fgd1_c.-31C>G 1 upstream_gene_variant 490752 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fgd1 c.360C>T fgd1_c.360C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 37 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fgd1 c.-38G>A fgd1_c.-38G>A 1 upstream_gene_variant 490745 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Delamanid fgd1 c.456C>T fgd1_c.456C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 244.222407132781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fgd1 c.465C>T fgd1_c.465C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 71 249 11323 0 0 0.0147055780339792 0.993768650166754 0.992146406832447 0.995130150706183 0 0 0.0506294079544037 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.44303718600787 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 10 54 496 0 0 0.0660315142444217 0.980237154150197 0.963956461825041 0.990483257236772 0 0 0.30849710781876 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.22559858346147 NA NA NA NA NA NA 671 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fgd1 c.48A>G fgd1_c.48A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fgd1 c.-4A>G fgd1_c.-4A>G 1 upstream_gene_variant 490779 1 2 0 2 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 244.222407132781 1 245.5 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fgd1 c.504G>C fgd1_c.504G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 0 NA NA NA 1 8 248 11386 0.00401606425702811 0.000101672774685082 0.0221717421523238 0.999297876075127 0.998617007237892 0.999696825539694 0.111111111111111 0.00280913674659921 0.482496514917337 NA NA NA NA NA NA NA NA NA NA NA NA False False 5.73891129032258 0.128820931013606 43.0083692344249 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fgd1 c.513C>G fgd1_c.513C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fgd1 c.51G>A fgd1_c.51G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fgd1 c.534C>T fgd1_c.534C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fgd1 c.546C>T fgd1_c.546C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fgd1 c.54C>A fgd1_c.54C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fgd1 c.552C>T fgd1_c.552C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 249 11390 0 0 0.0147055780339792 0.999648938037563 0.999101388115099 0.99990433941184 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 69.5552063788676 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 14 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fgd1 c.555C>G fgd1_c.555C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fgd1 c.567T>C fgd1_c.567T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.334370311011 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 15 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fgd1 c.606C>T fgd1_c.606C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fgd1 c.60C>T fgd1_c.60C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fgd1 c.666C>T fgd1_c.666C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 0 NA NA NA 1 2 248 11392 0.00401606425702811 0.000101672774685082 0.0221717421523238 0.999824469018782 0.99936606710312 0.999978741676894 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 22.9677419354838 0.387752230133854 440.62889055685 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 31 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fgd1 c.66A>G fgd1_c.66A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 244.222407132781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 12 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fgd1 c.741G>T fgd1_c.741G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 244.222407132781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 363.375224416517 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fgd1 c.750G>A fgd1_c.750G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fgd1 c.750G>T fgd1_c.750G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fgd1 c.774G>A fgd1_c.774G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 35 249 11359 0 0 0.0147055780339792 0.996928207828681 0.995730445513544 0.997859479868132 0 0 0.100032435572105 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.10690069444704 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 83 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fgd1 c.786C>T fgd1_c.786C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fgd1 c.816C>T fgd1_c.816C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 244.222407132781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fgd1 c.843C>G fgd1_c.843C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.334370311011 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fgd1 c.849C>T fgd1_c.849C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 363.375224416517 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fgd1 c.906A>G fgd1_c.906A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fgd1 c.915G>A fgd1_c.915G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 244.222407132781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fgd1 c.960T>C fgd1_c.960T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 172 6013 77 5381 0.690763052208835 0.629320340383768 0.747596510412423 0.472266104967526 0.463063639593847 0.481482747785156 0.0278092158447857 0.0238545245047728 0.032217166345427 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.99898488340197 1.51509712888539 2.65725938226172 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 42 338 12 168 0.777777777777777 0.644000905786651 0.879564217408901 0.332015810276679 0.29107975907133 0.374928484127891 0.110526315789473 0.0808277221005791 0.146453804343924 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.7396449704142 0.869980478094749 3.72586903095247 NA NA NA NA NA NA 21564 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fgd1 c.969C>G fgd1_c.969C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fgd1 c.982C>T fgd1_c.982C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 244.222407132781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid fgd1 deletion fgd1_deletion 1 feature_ablation (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 248 11394 0.00401606425702811 0.000101672774685082 0.0221717421523238 1 0.999676296088332 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 520 609 False False Inf 1.17330688615895 Inf 0 0 0.0147644348125545 1 0.999676296088332 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 53 506 0.0185185185185185 0.00046873840381796 0.0989151595078512 1 0.992736233998274 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 68 83 False False 0 0 0 0 0 0 0 Inf 0.240265883472405 Inf 0 0 0.0672345463063011 1 0.992736233998274 1 18 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim New AwRI no 5 +Delamanid fgd1 LoF fgd1_LoF 1 LoF (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 247 11394 0.00803212851405622 0.00097421250436962 0.028711995092973 1 0.999676296088332 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 608 609 False False Inf 8.61397407191288 Inf 0 0 0.0148237646055962 1 0.999676296088332 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 52 506 0.037037037037037 0.00451725629446049 0.127471772230947 1 0.992736233998274 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 83 83 False False 0 0 0 0 0 0 0 Inf 1.7775024572249 Inf 0 0 0.0684822087033195 1 0.992736233998274 1 NA Marker of R Selection evidence 2) Assoc w R - Interim Confers DLM-PMD cross-resistance New AwRI yes Selection R 5 +Delamanid fgd1 p.Ala10Val fgd1_p.Ala10Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fgd1 p.Ala188Thr fgd1_p.Ala188Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 525 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fgd1 p.Ala216Gly fgd1_p.Ala216Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fgd1 p.Ala2Val fgd1_p.Ala2Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 111.334370311011 1 245.5 609 False False 0 0 111.334370311011 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 0 0 0.975 0 0 0.975 0 0 363.375224416517 1 34 83 False False 0 0 0 0 0 0 0 0 0 363.375224416517 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 3 3) Uncertain significance No change no 1 +Delamanid fgd1 p.Ala35Val fgd1_p.Ala35Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 249 11390 0 0 0.0147055780339792 0.999648938037563 0.999101388115099 0.99990433941184 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 69.5552063788676 1 245.5 609 False False 0 0 69.5552063788676 0 0 0.0147055780339792 0.999648938037563 0.999101388115099 0.99990433941184 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fgd1 p.Arg187His fgd1_p.Arg187His 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 521 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 69 83 False False 0 0 0 0 0 0 0 0 0 363.375224416517 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 5 3) Uncertain significance No change no 1 +Delamanid fgd1 p.Arg18Cys fgd1_p.Arg18Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fgd1 p.Arg212Leu fgd1_p.Arg212Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fgd1 p.Arg45Cys fgd1_p.Arg45Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 249 11389 0 0 0.0147055780339792 0.999561172546954 0.998976222751812 0.99985749905819 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 50.1343664673437 1 245.5 609 False False 0 0 50.1343664673437 0 0 0.0147055780339792 0.999561172546954 0.998976222751812 0.99985749905819 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fgd1 p.Arg64Ser fgd1_p.Arg64Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 191 2 189 2 202 247 11192 0.00803212851405622 0.00097421250436962 0.028711995092973 0.982271370896963 0.97967745546558 0.984614478141149 0.00980392156862745 0.00118951343500511 0.034964511124087 0.0104712041884816 0.00127063657227603 0.0373117593369756 0.00980392156862745 0.00118951343500511 0.034964511124087 0.479489321594584 0.0573307385093848 1.77493224045132 0.445885551595965 41 609 False False 0.448631097927606 0.0536662493150056 1.65927929418559 0.00803212851405622 0.00097421250436962 0.028711995092973 0.982271370896963 0.97967745546558 0.984614478141149 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 54 504 0 0 0.0660315142444217 0.996047430830039 0.985795485070057 0.999520966589986 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 50.236220806896 1 34 83 False False 0 0 0 0 0 0 0 0 0 50.236220806896 0 0 0.0660315142444217 0.996047430830039 0.985795485070057 0.999520966589986 436 3) Uncertain significance No change no 1 +Delamanid fgd1 p.Asn112fs fgd1_p.Asn112fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 248 11394 0.00401606425702811 0.000101672774685082 0.0221717421523238 1 0.999676296088332 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 529 609 False False Inf 1.17330688615895 Inf 0 0 0.0147644348125545 1 0.999676296088332 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 1 0 53 506 0.0185185185185185 0.00046873840381796 0.0989151595078512 1 0.992736233998274 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.240265883472405 Inf 0.0964285714285713 5 83 False False 0 0 0 0 0 0 0 Inf 0.240265883472405 Inf 0.0185185185185185 0.00046873840381796 0.0989151595078512 1 0.992736233998274 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim New AwRI no 5 +Delamanid fgd1 p.Asn66Ser fgd1_p.Asn66Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fgd1 p.Asp190Glu fgd1_p.Asp190Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 248 11394 0.00401606425702811 0.000101672774685082 0.0221717421523238 1 0.999676296088332 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 1.17330688615895 Inf 0.0213862406596237 17.5 609 False False Inf 1.17330688615895 Inf 0.00401606425702811 0.000101672774685082 0.0221717421523238 1 0.999676296088332 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fgd1 p.Asp273Gly fgd1_p.Asp273Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fgd1 p.Asp33Gly fgd1_p.Asp33Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 244.222407132781 1 245.5 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fgd1 p.Gln279Pro fgd1_p.Gln279Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 530 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fgd1 p.Gln47Leu fgd1_p.Gln47Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Delamanid fgd1 p.Glu119Asp fgd1_p.Glu119Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 1736.06792348613 1 245.5 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Delamanid fgd1 p.Glu119Lys fgd1_p.Glu119Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 527 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fgd1 p.Glu19Asp fgd1_p.Glu19Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 522 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fgd1 p.Glu240Gly fgd1_p.Glu240Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 528 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fgd1 p.Glu269Lys fgd1_p.Glu269Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 518 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fgd1 p.Gly137Glu fgd1_p.Gly137Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 523 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fgd1 p.Gly168Arg fgd1_p.Gly168Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 524 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 3) Uncertain significance No change no 1 +Delamanid fgd1 p.Gly169Asp fgd1_p.Gly169Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 514 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 67 83 False False 0 0 0 0 0 0 0 0 0 363.375224416517 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 NA 3) Uncertain significance New Uncertain no 0 +Delamanid fgd1 p.Gly224Asp fgd1_p.Gly224Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 0 0 0.975 0 0 0.975 0 0 363.375224416517 1 34 83 False False 0 0 0 0 0 0 0 0 0 363.375224416517 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 3 3) Uncertain significance New Uncertain no 0 +Delamanid fgd1 p.Gly7Ser fgd1_p.Gly7Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fgd1 p.His260Pro fgd1_p.His260Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fgd1 p.His315Asp fgd1_p.His315Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 533 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid fgd1 p.His315Tyr fgd1_p.His315Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 531 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Delamanid fgd1 p.Ile174_Glu295del fgd1_p.Ile174_Glu295del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 248 11394 0.00401606425702811 0.000101672774685082 0.0221717421523238 1 0.999676296088332 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 1.17330688615895 Inf 0.0213862406596237 17.5 609 False False Inf 1.17330688615895 Inf 0.00401606425702811 0.000101672774685082 0.0221717421523238 1 0.999676296088332 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 53 506 0.0185185185185185 0.00046873840381796 0.0989151595078512 1 0.992736233998274 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.240265883472405 Inf 0.0964285714285713 5 83 False False 0 0 0 0 0 0 0 Inf 0.240265883472405 Inf 0.0185185185185185 0.00046873840381796 0.0989151595078512 1 0.992736233998274 1 NA 3) Uncertain significance New Uncertain no 0 +Delamanid fgd1 p.Ile229Thr fgd1_p.Ile229Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fgd1 p.Ile86Leu fgd1_p.Ile86Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 515 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fgd1 p.Leu323Phe fgd1_p.Leu323Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 249 11390 0 0 0.0147055780339792 0.999648938037563 0.999101388115099 0.99990433941184 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 516 609 False False 0 0 69.5552063788676 0 0 0.0147055780339792 0.999648938037563 0.999101388115099 0.99990433941184 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 59 3) Uncertain significance No change no 1 +Delamanid fgd1 p.Lys183Met fgd1_p.Lys183Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 1 5 1 5 248 11389 0.00401606425702811 0.000101672774685082 0.0221717421523238 0.999561172546954 0.998976222751812 0.99985749905819 0.166666666666666 0.00421074451448947 0.641234578997674 0.166666666666666 0.00421074451448947 0.641234578997674 0.166666666666666 0.00421074451448947 0.641234578997674 9.18467741935484 0.193417807211944 82.3894727820671 0.121674129728306 33.5 609 False False 9.18467741935484 0.193417807211944 82.3894727820671 0.00401606425702811 0.000101672774685082 0.0221717421523238 0.999561172546954 0.998976222751812 0.99985749905819 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 75 3) Uncertain significance No change no 1 +Delamanid fgd1 p.Lys183Thr fgd1_p.Lys183Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Delamanid fgd1 p.Lys270Met fgd1_p.Lys270Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 857 8 849 14 971 235 10423 0.0562248995983935 0.0310760835514842 0.0925372446174912 0.914779708618571 0.909502475280304 0.919843861536509 0.0142131979695431 0.00779169195836907 0.0237324450544169 0.00933488914819136 0.00403851258121446 0.0183102173164277 0.00817160367722165 0.00353432931358151 0.0160375267652435 0.417933488710122 0.177744031678149 0.841189618666417 0.0091282836441026 9 609 False False 0.639489887591208 0.342903568079512 1.1002318187426 0.0329218106995884 0.0143184266976492 0.0638360755053677 0.914779708618571 0.909502475280304 0.919843861536509 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 2 10 52 496 0.037037037037037 0.00451725629446049 0.127471772230947 0.980237154150197 0.963956461825041 0.990483257236772 0.166666666666666 0.0208625254600923 0.484137748685967 0 0 0.369416647552819 0 0 0.30849710781876 0 0 5.75662126007931 1 34 83 False False 0 0 0 0 0 0 0 1.9076923076923 0.197808173630283 9.29841786883907 0 0 0.0684822087033195 0.980237154150197 0.963956461825041 0.990483257236772 3358 3) Uncertain significance No change no 1 +Delamanid fgd1 p.Lys296Arg fgd1_p.Lys296Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 249 11390 0 0 0.0147055780339792 0.999648938037563 0.999101388115099 0.99990433941184 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 244.179524589186 1 245.5 609 False False 0 0 69.5552063788676 0 0 0.0147055780339792 0.999648938037563 0.999101388115099 0.99990433941184 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 29 3) Uncertain significance No change no 1 +Delamanid fgd1 p.Lys296Glu fgd1_p.Lys296Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 10 249 11384 0 0 0.0147055780339792 0.999122345093909 0.998386555629556 0.999579052676482 0 0 0.30849710781876 NA NA NA 0 0 0.30849710781876 NA NA NA NA 526 609 False False 0 0 20.5112934421461 0 0 0.0147055780339792 0.999122345093909 0.998386555629556 0.999579052676482 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 59 3) Uncertain significance No change no 1 +Delamanid fgd1 p.Met139Ile fgd1_p.Met139Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fgd1 p.Met93Thr fgd1_p.Met93Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 13 0 13 0 16 249 11378 0 0 0.0147055780339792 0.998595752150254 0.997720588509296 0.99919714469723 0 0 0.205907214207822 0 0 0.24705263800047 0 0 0.205907214207822 0 0 15.0846904195374 1 245.5 609 False False 0 0 11.9219739008791 0 0 0.0147055780339792 0.998595752150254 0.997720588509296 0.99919714469723 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 76 3) Uncertain significance No change no 1 +Delamanid fgd1 p.Pro166Leu fgd1_p.Pro166Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fgd1 p.Ser56Cys fgd1_p.Ser56Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 0 0 0.975 0 0 0.975 0 0 363.375224416517 1 34 83 False False 0 0 0 0 0 0 0 0 0 363.375224416517 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 2 3) Uncertain significance New Uncertain no 0 +Delamanid fgd1 p.Thr255Ala fgd1_p.Thr255Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 249 11390 0 0 0.0147055780339792 0.999648938037563 0.999101388115099 0.99990433941184 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 111.324479323847 1 245.5 609 False False 0 0 69.5552063788676 0 0 0.0147055780339792 0.999648938037563 0.999101388115099 0.99990433941184 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 12 3) Uncertain significance No change no 1 +Delamanid fgd1 p.Thr255Pro fgd1_p.Thr255Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 517 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fgd1 p.Tyr118Ser fgd1_p.Tyr118Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Delamanid fgd1 p.Tyr163Cys fgd1_p.Tyr163Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 26 3) Uncertain significance No change no 1 +Delamanid fgd1 p.Tyr81His fgd1_p.Tyr81His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid fgd1 p.Val136Met fgd1_p.Val136Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fgd1 p.Val170Met fgd1_p.Val170Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 230 4 226 4 228 245 11166 0.0160642570281124 0.00439386976737239 0.0406178175213521 0.979989468141126 0.977248220994274 0.982481424419155 0.0172413793103448 0.00471717303660686 0.043553978600773 0.017391304347826 0.00475836401156378 0.0439275533710168 0.0172413793103448 0.00471717303660686 0.043553978600773 0.806646198302329 0.216160847129763 2.12079058838967 1 245.5 609 False False 0.799570354457572 0.214280853866609 2.10190030491694 0.0160642570281124 0.00439386976737239 0.0406178175213521 0.979989468141126 0.977248220994274 0.982481424419155 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 464 3) Uncertain significance No change no 1 +Delamanid fgd1 p.Val286Ala fgd1_p.Val286Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid fgd1 p.Val294Ala fgd1_p.Val294Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Delamanid fgd1 p.Val37Gly fgd1_p.Val37Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 519 609 False False 0 0 111.334370311011 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid ndh c.1017G>A ndh_c.1017G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.1032C>G ndh_c.1032C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.334370311011 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.1044G>A ndh_c.1044G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.1080G>A ndh_c.1080G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.108C>T ndh_c.108C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.1122G>A ndh_c.1122G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.334370311011 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 75 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.1128T>C ndh_c.1128T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.1140C>G ndh_c.1140C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.1152C>G ndh_c.1152C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 244.222407132781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.1194G>A ndh_c.1194G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.1195C>T ndh_c.1195C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 13 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.1203G>A ndh_c.1203G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 244.222407132781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.1209C>T ndh_c.1209C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 363.375224416517 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.120C>A ndh_c.120C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.1210C>T ndh_c.1210C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.1212G>A ndh_c.1212G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 18 249 11376 0 0 0.0147055780339792 0.998420221169036 0.997504413129461 0.999063462626473 0 0 0.185301968137852 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 10.463148258376 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 66 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.1314G>A ndh_c.1314G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.1320G>C ndh_c.1320G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 249 11389 0 0 0.0147055780339792 0.999561172546954 0.998976222751812 0.99985749905819 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 50.1343664673437 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.1332G>A ndh_c.1332G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.138C>T ndh_c.138C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.147C>T ndh_c.147C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.148C>T ndh_c.148C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.156G>A ndh_c.156G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.159G>A ndh_c.159G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 249 11390 0 0 0.0147055780339792 0.999648938037563 0.999101388115099 0.99990433941184 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 69.5552063788676 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.180C>T ndh_c.180C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.186T>C ndh_c.186T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.-1C>G ndh_c.-1C>G 2 upstream_gene_variant 2103043 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 589 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh c.204C>A ndh_c.204C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.21C>G ndh_c.21C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 24 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.228G>A ndh_c.228G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 248 11394 0.00401606425702811 0.000101672774685082 0.0221717421523238 1 0.999676296088332 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.17330688615895 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.-23G>A ndh_c.-23G>A 2 upstream_gene_variant 2103065 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Delamanid ndh c.252A>C ndh_c.252A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 9 248 11385 0.00401606425702811 0.000101672774685082 0.0221717421523238 0.999210110584518 0.998501075795816 0.999638750670416 0.1 0.00252857854446178 0.445016117028195 NA NA NA NA NA NA NA NA NA NA NA NA False False 5.1008064516129 0.115912410043891 37.0389045037412 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.255G>A ndh_c.255G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.267C>T ndh_c.267C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.270C>G ndh_c.270C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.315T>G ndh_c.315T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.324C>T ndh_c.324C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 244.222407132781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.33A>G ndh_c.33A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.372T>C ndh_c.372T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.387C>T ndh_c.387C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 244.222407132781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.408C>A ndh_c.408C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.-40A>G ndh_c.-40A>G 2 upstream_gene_variant 2103082 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh c.411C>T ndh_c.411C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.-45A>G ndh_c.-45A>G 2 upstream_gene_variant 2103087 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh c.46C>A ndh_c.46C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.498G>A ndh_c.498G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.334370311011 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.-54G>T ndh_c.-54G>T 2 upstream_gene_variant 2103096 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh c.561A>C ndh_c.561A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 248 11394 0.00401606425702811 0.000101672774685082 0.0221717421523238 1 0.999676296088332 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.17330688615895 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.570C>T ndh_c.570C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.-57A>G ndh_c.-57A>G 2 upstream_gene_variant 2103099 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 598 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Delamanid ndh c.606G>C ndh_c.606G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.615C>T ndh_c.615C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.633G>A ndh_c.633G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.639G>A ndh_c.639G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.-65G>A ndh_c.-65G>A 2 upstream_gene_variant 2103107 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh c.675C>T ndh_c.675C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.-70G>T ndh_c.-70G>T 2 upstream_gene_variant 2103112 1 2 0 2 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 244.200965863688 1 47 609 False False 0 0 111.334370311011 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 74 3) Uncertain significance New Uncertain no 0 +Delamanid ndh c.753C>T ndh_c.753C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.768C>T ndh_c.768C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.822G>A ndh_c.822G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.334370311011 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.834C>T ndh_c.834C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.858C>T ndh_c.858C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.864C>T ndh_c.864C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 244.222407132781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.894C>T ndh_c.894C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.897G>A ndh_c.897G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.903C>T ndh_c.903C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 249 11389 0 0 0.0147055780339792 0.999561172546954 0.998976222751812 0.99985749905819 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 50.1343664673437 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.906G>A ndh_c.906G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.924C>T ndh_c.924C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.948C>T ndh_c.948C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 111.334370311011 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 54 504 0 0 0.0660315142444217 0.996047430830039 0.985795485070057 0.999520966589986 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 50.236220806896 NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.-95A>G ndh_c.-95A>G 2 upstream_gene_variant 2103137 1 1 0 1 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 1736.06792348613 1 245.5 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Delamanid ndh c.960G>A ndh_c.960G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 248 11393 0.00401606425702811 0.000101672774685082 0.0221717421523238 0.99991223450939 0.999511100073968 0.999997777972629 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 45.9395161290322 0.582902810663616 3482.48283416238 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.984T>C ndh_c.984T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh c.984T>G ndh_c.984T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 244.222407132781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 363.375224416517 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid ndh deletion ndh_deletion 2 feature_ablation (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 602 609 False False 0 0 111.334370311011 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 80 83 False False 0 0 0 0 0 0 0 0 0 363.375224416517 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 4 3) Uncertain significance New Uncertain no 0 +Delamanid ndh LoF ndh_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 28 2 26 2 41 247 11353 0.00803212851405622 0.00097421250436962 0.028711995092973 0.996401614885027 0.995121517747247 0.997416536592855 0.0465116279069767 0.00568325697874796 0.158111458308697 0.0714285714285714 0.00877049670352713 0.23503477317459 0.0465116279069767 0.00568325697874796 0.158111458308697 3.53565867331049 0.404414811629675 14.2523995617221 0.120142067210517 32 609 False False 2.24212501234324 0.261244727897653 8.715456706667 0.00803212851405622 0.00097421250436962 0.028711995092973 0.996401614885027 0.995121517747247 0.997416536592855 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 0 10 54 496 0 0 0.0660315142444217 0.980237154150197 0.963956461825041 0.990483257236772 0 0 0.30849710781876 0 0 0.336267116879942 0 0 0.30849710781876 0 0 4.79447290761606 1 34 83 False False 0 0 0 0 0 0 0 0 0 4.22559858346147 0 0 0.0660315142444217 0.980237154150197 0.963956461825041 0.990483257236772 NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Ala121Thr ndh_p.Ala121Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 2 247 11392 0.00803212851405622 0.00097421250436962 0.028711995092973 0.999824469018782 0.99936606710312 0.999978741676894 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 590 609 False False 46.1214574898785 3.32444398842227 649.03342696195 0 0 0.0148237646055962 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 1 52 505 0.037037037037037 0.00451725629446049 0.127471772230947 0.998023715415019 0.989038460642947 0.999949966058094 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 79 83 False False 0 0 0 0 0 0 0 19.4230769230769 0.983783936598918 1138.32179495312 0 0 0.0684822087033195 0.998023715415019 0.989038460642947 0.999949966058094 NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Ala154Val ndh_p.Ala154Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 249 11390 0 0 0.0147055780339792 0.999648938037563 0.999101388115099 0.99990433941184 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 111.324479323847 1 245.5 609 False False 0 0 69.5552063788676 0 0 0.0147055780339792 0.999648938037563 0.999101388115099 0.99990433941184 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Ala158Thr ndh_p.Ala158Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 594 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Ala209Val ndh_p.Ala209Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 249 11390 0 0 0.0147055780339792 0.999648938037563 0.999101388115099 0.99990433941184 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 69.5552063788676 1 245.5 609 False False 0 0 69.5552063788676 0 0 0.0147055780339792 0.999648938037563 0.999101388115099 0.99990433941184 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 0 0 0.975 0 0 0.975 0 0 363.375224416517 1 34 83 False False 0 0 0 0 0 0 0 0 0 363.375224416517 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 64 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Ala233Thr ndh_p.Ala233Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 244.222407132781 1 245.5 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Ala300Asp ndh_p.Ala300Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Ala324fs ndh_p.Ala324fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 1736.06792348613 1 245.5 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 15 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Ala325fs ndh_p.Ala325fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 244.222407132781 1 245.5 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Ala336fs ndh_p.Ala336fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 587 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Ala340fs ndh_p.Ala340fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Ala340Thr ndh_p.Ala340Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Ala380Val ndh_p.Ala380Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 249 11390 0 0 0.0147055780339792 0.999648938037563 0.999101388115099 0.99990433941184 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 111.324479323847 1 245.5 609 False False 0 0 69.5552063788676 0 0 0.0147055780339792 0.999648938037563 0.999101388115099 0.99990433941184 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Ala44Gly ndh_p.Ala44Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 584 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Ala59fs ndh_p.Ala59fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Ala9Glu ndh_p.Ala9Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Ala9Thr ndh_p.Ala9Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 1735.91967638177 1 47 609 False False 0 0 111.334370311011 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Arg13Leu ndh_p.Arg13Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Arg16Gln ndh_p.Arg16Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Arg235Gln ndh_p.Arg235Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 244.222407132781 1 245.5 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Arg254Cys ndh_p.Arg254Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 244.222407132781 1 245.5 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Arg268His ndh_p.Arg268His 2 missense_variant (see "Genomic_coordinates" sheet) 1 97 2 95 2 96 247 11298 0.00803212851405622 0.00097421250436962 0.028711995092973 0.991574512901527 0.989720638453918 0.993170151523371 0.0204081632653061 0.00248114987873316 0.0717820571701025 0.0206185567010309 0.00250682976381727 0.0725021499263911 0.0204081632653061 0.00248114987873316 0.0717820571701025 0.962966119752823 0.114310045153716 3.61257622095054 1 245.5 609 False False 0.952935222672064 0.113136113275657 3.57401393869644 0.00803212851405622 0.00097421250436962 0.028711995092973 0.991574512901527 0.989720638453918 0.993170151523371 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 0 0 0.975 0 0 0.975 0 0 363.375224416517 1 34 83 False False 0 0 0 0 0 0 0 0 0 363.375224416517 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 354 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Arg284Trp ndh_p.Arg284Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 0 0 0.975 0 0 0.975 0 0 363.375224416517 1 34 83 False False 0 0 0 0 0 0 0 0 0 363.375224416517 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 45 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Arg294Trp ndh_p.Arg294Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 585 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Arg45Cys ndh_p.Arg45Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 595 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Asn28_Ala29delinsLys ndh_p.Asn28_Ala29delinsLys 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Asp251Glu ndh_p.Asp251Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 111.334370311011 1 245.5 609 False False 0 0 111.334370311011 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Asp288Ala ndh_p.Asp288Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Gln10Lys ndh_p.Gln10Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Gln244fs ndh_p.Gln244fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Gln334fs ndh_p.Gln334fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 244.222407132781 1 245.5 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 54 504 0 0 0.0660315142444217 0.996047430830039 0.985795485070057 0.999520966589986 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 50.236220806896 1 34 83 False False 0 0 0 0 0 0 0 0 0 50.236220806896 0 0 0.0660315142444217 0.996047430830039 0.985795485070057 0.999520966589986 NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Gln363Ser ndh_p.Gln363Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 7 249 11387 0 0 0.0147055780339792 0.999385641565736 0.998734599099098 0.99975296150752 0 0 0.409616397225003 0 0 0.602364635616474 0 0 0.409616397225003 0 0 69.536902301255 1 245.5 609 False False 0 0 31.8900809629541 0 0 0.0147055780339792 0.999385641565736 0.998734599099098 0.99975296150752 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 81 83 False False 0 0 0 0 0 0 0 0 0 363.375224416517 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 40 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Gln97Arg ndh_p.Gln97Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Glu146Ala ndh_p.Glu146Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 244.222407132781 1 245.5 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 54 504 0 0 0.0660315142444217 0.996047430830039 0.985795485070057 0.999520966589986 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 50.236220806896 1 34 83 False False 0 0 0 0 0 0 0 0 0 50.236220806896 0 0 0.0660315142444217 0.996047430830039 0.985795485070057 0.999520966589986 NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Glu159Lys ndh_p.Glu159Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 591 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Glu270Asp ndh_p.Glu270Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Glu327Ala ndh_p.Glu327Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Glu350Asp ndh_p.Glu350Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Glu360Lys ndh_p.Glu360Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 244.200965863688 1 47 609 False False 0 0 111.334370311011 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 0 0 0.975 0 0 0.975 0 0 363.375224416517 1 34 83 False False 0 0 0 0 0 0 0 0 0 363.375224416517 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Glu6fs ndh_p.Glu6fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 1736.06792348613 1 245.5 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Gly122Ser ndh_p.Gly122Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 599 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Gly179Asp ndh_p.Gly179Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 604 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Gly179fs ndh_p.Gly179fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 606 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Gly246Ala ndh_p.Gly246Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Gly246Ser ndh_p.Gly246Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 244.222407132781 1 245.5 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 54 504 0 0 0.0660315142444217 0.996047430830039 0.985795485070057 0.999520966589986 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 50.236220806896 1 34 83 False False 0 0 0 0 0 0 0 0 0 50.236220806896 0 0 0.0660315142444217 0.996047430830039 0.985795485070057 0.999520966589986 2 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Gly313Arg ndh_p.Gly313Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 10 0 10 0 15 249 11379 0 0 0.0147055780339792 0.998683517640863 0.997829590662573 0.999262993506047 0 0 0.218019360910534 0 0 0.30849710781876 0 0 0.218019360910534 0 0 20.5024704292178 1 245.5 609 False False 0 0 12.8196237693957 0 0 0.0147055780339792 0.998683517640863 0.997829590662573 0.999262993506047 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 87 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Gly331fs ndh_p.Gly331fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Gly339Ala ndh_p.Gly339Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Gly389Asp ndh_p.Gly389Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Gly389Ser ndh_p.Gly389Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.His106Arg ndh_p.His106Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 1736.06792348613 1 245.5 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 37 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.His106fs ndh_p.His106fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 583 609 False False 0 0 111.334370311011 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Ile20Thr ndh_p.Ile20Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Ile212fs ndh_p.Ile212fs 2 frameshift (see "Genomic_coordinates" sheet) 1 8 1 7 1 7 248 11387 0.00401606425702811 0.000101672774685082 0.0221717421523238 0.999385641565736 0.998734599099098 0.99975296150752 0.125 0.0031597235312519 0.526509670875206 0.125 0.0031597235312519 0.526509670875206 0.125 0.0031597235312519 0.526509670875206 6.55933179723502 0.144961668339134 51.390023884054 0.158861121824517 37 609 False False 6.55933179723502 0.144961668339134 51.390023884054 0.00401606425702811 0.000101672774685082 0.0221717421523238 0.999385641565736 0.998734599099098 0.99975296150752 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 54 501 0 0 0.0660315142444217 0.990118577075098 0.977091674593924 0.996783963293044 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 10.3667075351405 1 34 83 False False 0 0 0 0 0 0 0 0 0 10.3667075351405 0 0 0.0660315142444217 0.990118577075098 0.977091674593924 0.996783963293044 1 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Ile269Val ndh_p.Ile269Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Ile337fs ndh_p.Ile337fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Ile62Ser ndh_p.Ile62Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Ile63Thr ndh_p.Ile63Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 244.222407132781 1 245.5 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Leu103fs ndh_p.Leu103fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Leu104fs ndh_p.Leu104fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 588 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Leu170Pro ndh_p.Leu170Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Leu228fs ndh_p.Leu228fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 596 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Leu309Arg ndh_p.Leu309Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 586 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Leu33Pro ndh_p.Leu33Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 605 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Leu415Pro ndh_p.Leu415Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Leu54Pro ndh_p.Leu54Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Lys169Glu ndh_p.Lys169Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Lys460Glu ndh_p.Lys460Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 244.222407132781 1 245.5 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Lys78Asn ndh_p.Lys78Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Met1? ndh_p.Met1? 2 start_lost (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Phe365Leu ndh_p.Phe365Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Pro111His ndh_p.Pro111His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 592 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Pro136fs ndh_p.Pro136fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Pro330fs ndh_p.Pro330fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 0 0 0.975 0 0 0.975 0 0 363.375224416517 1 34 83 False False 0 0 0 0 0 0 0 0 0 363.375224416517 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Pro330Ser ndh_p.Pro330Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 20 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Pro384Arg ndh_p.Pro384Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 600 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Pro7Leu ndh_p.Pro7Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 249 11390 0 0 0.0147055780339792 0.999648938037563 0.999101388115099 0.99990433941184 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 69.5552063788676 1 245.5 609 False False 0 0 69.5552063788676 0 0 0.0147055780339792 0.999648938037563 0.999101388115099 0.99990433941184 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Ser206Pro ndh_p.Ser206Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Ser345Arg ndh_p.Ser345Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Ser388Gly ndh_p.Ser388Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Ser423Arg ndh_p.Ser423Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 244.222407132781 1 245.5 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Thr110fs ndh_p.Thr110fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 0 0 0.975 0 0 0.975 0 0 363.375224416517 1 34 83 False False 0 0 0 0 0 0 0 0 0 363.375224416517 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Thr174Ala ndh_p.Thr174Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Thr418Ala ndh_p.Thr418Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 601 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Thr432Pro ndh_p.Thr432Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 244.222407132781 1 245.5 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Thr47Ser ndh_p.Thr47Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 249 11389 0 0 0.0147055780339792 0.999561172546954 0.998976222751812 0.99985749905819 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 50.1343664673437 1 245.5 609 False False 0 0 50.1343664673437 0 0 0.0147055780339792 0.999561172546954 0.998976222751812 0.99985749905819 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 12 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Thr8fs ndh_p.Thr8fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 603 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Thr8Lys ndh_p.Thr8Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Tyr112fs ndh_p.Tyr112fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Tyr112His ndh_p.Tyr112His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Tyr112* ndh_p.Tyr112* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 582 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Tyr342Asp ndh_p.Tyr342Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Tyr342* ndh_p.Tyr342* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 248 11394 0.00401606425702811 0.000101672774685082 0.0221717421523238 1 0.999676296088332 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 1.17330688615895 Inf 0.0213862406596237 17.5 609 False False Inf 1.17330688615895 Inf 0.00401606425702811 0.000101672774685082 0.0221717421523238 1 0.999676296088332 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Tyr364Asp ndh_p.Tyr364Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Tyr56* ndh_p.Tyr56* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Val117Ile ndh_p.Val117Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 249 11390 0 0 0.0147055780339792 0.999648938037563 0.999101388115099 0.99990433941184 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 69.5552063788676 1 245.5 609 False False 0 0 69.5552063788676 0 0 0.0147055780339792 0.999648938037563 0.999101388115099 0.99990433941184 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 16 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Val18Ala ndh_p.Val18Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 317 3 314 4 318 245 11076 0.0160642570281124 0.00439386976737239 0.0406178175213521 0.972090573986308 0.968899017149293 0.975037740673388 0.0124223602484472 0.0033947658951062 0.0314990455969468 0.00946372239747634 0.00195591541967846 0.0274064226457887 0.00934579439252336 0.00193148991891029 0.0270679812385833 0.431925126738593 0.0879816620400444 1.28912045078703 0.167023884030853 39 609 False False 0.568656141701963 0.152756826716519 1.48929728152127 0.0120967741935483 0.00250162694177808 0.034942928632533 0.972090573986308 0.968899017149293 0.975037740673388 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 6 54 500 0 0 0.0660315142444217 0.988142292490118 0.97437044953677 0.995636339212082 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 10.3460995307036 1 34 83 False False 0 0 0 0 0 0 0 0 0 8.06959148434815 0 0 0.0660315142444217 0.988142292490118 0.97437044953677 0.995636339212082 1049 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Val220Leu ndh_p.Val220Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 244.222407132781 1 245.5 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Val241Ala ndh_p.Val241Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 597 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Val326Met ndh_p.Val326Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 244.222407132781 1 245.5 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Val332fs ndh_p.Val332fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Val332Gly ndh_p.Val332Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 593 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid ndh p.Val99Ala ndh_p.Val99Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid Rv2983 c.147C>T Rv2983_c.147C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid Rv2983 c.15G>C Rv2983_c.15G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid Rv2983 c.183T>C Rv2983_c.183T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid Rv2983 c.186C>T Rv2983_c.186C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid Rv2983 c.189C>A Rv2983_c.189C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid Rv2983 c.-1C>A Rv2983_c.-1C>A 1 upstream_gene_variant 3339117 1 0 0 0 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 565 609 False False 0 0 111.334370311011 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 3) Uncertain significance No change no 1 +Delamanid Rv2983 c.216G>A Rv2983_c.216G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 11 248 11383 0.00401606425702811 0.000101672774685082 0.0221717421523238 0.9990345796033 0.99827325433968 0.99951797022408 0.0833333333333333 0.00210759323186022 0.384796165150944 NA NA NA NA NA NA NA NA NA NA NA NA False False 4.17265395894428 0.0965564075990008 28.9063856632706 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 53 506 0.0185185185185185 0.00046873840381796 0.0989151595078512 1 0.992736233998274 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.240265883472405 Inf NA NA NA NA NA NA 11 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid Rv2983 c.240G>A Rv2983_c.240G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 363.375224416517 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid Rv2983 c.285C>T Rv2983_c.285C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid Rv2983 c.300A>G Rv2983_c.300A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 52 247 11342 0.00803212851405622 0.00097421250436962 0.028711995092973 0.995436194488327 0.9940194311724 0.996589709559756 0.037037037037037 0.00451725629446049 0.127471772230947 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.76611647461849 0.207193798933892 6.77554550426963 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 54 503 0 0 0.0660315142444217 0.994071146245059 0.982771870681216 0.998775654961114 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.9227911903789 NA NA NA NA NA NA 919 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid Rv2983 c.303C>T Rv2983_c.303C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 244.222407132781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid Rv2983 c.-34G>C Rv2983_c.-34G>C 1 upstream_gene_variant 3339084 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Delamanid Rv2983 c.354G>A Rv2983_c.354G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid Rv2983 c.369G>A Rv2983_c.369G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid Rv2983 c.399C>A Rv2983_c.399C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 10 249 11384 0 0 0.0147055780339792 0.999122345093909 0.998386555629556 0.999579052676482 0 0 0.30849710781876 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.5112934421461 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid Rv2983 c.444C>G Rv2983_c.444C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 0 248 11394 0.00401606425702811 0.000101672774685082 0.0221717421523238 1 0.999676296088332 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.17330688615895 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid Rv2983 c.444C>T Rv2983_c.444C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 244.222407132781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid Rv2983 c.459G>C Rv2983_c.459G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid Rv2983 c.-4C>T Rv2983_c.-4C>T 1 upstream_gene_variant 3339114 1 2 0 2 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 244.222407132781 1 245.5 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid Rv2983 c.504G>A Rv2983_c.504G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 244.222407132781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid Rv2983 c.-50G>C Rv2983_c.-50G>C 1 upstream_gene_variant 3339068 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Delamanid Rv2983 c.513C>T Rv2983_c.513C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 244.222407132781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 37 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid Rv2983 c.561C>T Rv2983_c.561C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 244.222407132781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid Rv2983 c.564T>C Rv2983_c.564T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1736.21616988455 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid Rv2983 c.624G>A Rv2983_c.624G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 244.222407132781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 23 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid Rv2983 c.636A>G Rv2983_c.636A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 244.222407132781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Delamanid Rv2983 LoF Rv2983_LoF 1 LoF (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Marker of R Selection evidence 2) Assoc w R - Interim Confers DLM-PMD cross-resistance New AwRI yes Selection R 5 +Delamanid Rv2983 p.Ala107Asp Rv2983_p.Ala107Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 555 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid Rv2983 p.Ala107Val Rv2983_p.Ala107Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 553 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 71 83 False False 0 0 0 0 0 0 0 0 0 363.375224416517 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 23 3) Uncertain significance New Uncertain no 0 +Delamanid Rv2983 p.Ala119Val Rv2983_p.Ala119Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 562 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid Rv2983 p.Ala157Glu Rv2983_p.Ala157Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid Rv2983 p.Ala20Val Rv2983_p.Ala20Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 111.334370311011 1 245.5 609 False False 0 0 111.334370311011 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Delamanid Rv2983 p.Ala210Ser Rv2983_p.Ala210Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid Rv2983 p.Ala210Val Rv2983_p.Ala210Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid Rv2983 p.Ala21Thr Rv2983_p.Ala21Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 249 11390 0 0 0.0147055780339792 0.999648938037563 0.999101388115099 0.99990433941184 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 69.5552063788676 1 245.5 609 False False 0 0 69.5552063788676 0 0 0.0147055780339792 0.999648938037563 0.999101388115099 0.99990433941184 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance No change no 1 +Delamanid Rv2983 p.Ala32Thr Rv2983_p.Ala32Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 249 11390 0 0 0.0147055780339792 0.999648938037563 0.999101388115099 0.99990433941184 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 69.5552063788676 1 245.5 609 False False 0 0 69.5552063788676 0 0 0.0147055780339792 0.999648938037563 0.999101388115099 0.99990433941184 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Delamanid Rv2983 p.Ala50Thr Rv2983_p.Ala50Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 552 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid Rv2983 p.Ala68Thr Rv2983_p.Ala68Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid Rv2983 p.Arg101His Rv2983_p.Arg101His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid Rv2983 p.Arg101Leu Rv2983_p.Arg101Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid Rv2983 p.Arg169Gln Rv2983_p.Arg169Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 111.334370311011 1 245.5 609 False False 0 0 111.334370311011 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid Rv2983 p.Arg171His Rv2983_p.Arg171His 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 563 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 74 83 False False 0 0 0 0 0 0 0 0 0 363.375224416517 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 NA 3) Uncertain significance New Uncertain no 0 +Delamanid Rv2983 p.Arg172Ser Rv2983_p.Arg172Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 561 609 False False 0 0 111.334370311011 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 54 503 0 0 0.0660315142444217 0.994071146245059 0.982771870681216 0.998775654961114 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 73 83 False False 0 0 0 0 0 0 0 0 0 22.9227911903789 0 0 0.0660315142444217 0.994071146245059 0.982771870681216 0.998775654961114 NA 3) Uncertain significance New Uncertain no 0 +Delamanid Rv2983 p.Arg209Gln Rv2983_p.Arg209Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 551 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Delamanid Rv2983 p.Arg57Leu Rv2983_p.Arg57Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 249 11389 0 0 0.0147055780339792 0.999561172546954 0.998976222751812 0.99985749905819 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 50.1343664673437 1 245.5 609 False False 0 0 50.1343664673437 0 0 0.0147055780339792 0.999561172546954 0.998976222751812 0.99985749905819 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 19 3) Uncertain significance No change no 1 +Delamanid Rv2983 p.Asn37Asp Rv2983_p.Asn37Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Delamanid Rv2983 p.Asp78Asn Rv2983_p.Asp78Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 557 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid Rv2983 p.Asp90Asn Rv2983_p.Asp90Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 10 0 10 0 10 249 11384 0 0 0.0147055780339792 0.999122345093909 0.998386555629556 0.999579052676482 0 0 0.30849710781876 0 0 0.30849710781876 0 0 0.30849710781876 0 0 20.5112934421461 1 245.5 609 False False 0 0 20.5112934421461 0 0 0.0147055780339792 0.999122345093909 0.998386555629556 0.999579052676482 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 54 503 0 0 0.0660315142444217 0.994071146245059 0.982771870681216 0.998775654961114 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 22.9227911903789 1 34 83 False False 0 0 0 0 0 0 0 0 0 22.9227911903789 0 0 0.0660315142444217 0.994071146245059 0.982771870681216 0.998775654961114 45 3) Uncertain significance No change no 1 +Delamanid Rv2983 p.Gln121His Rv2983_p.Gln121His 1 missense_variant (see "Genomic_coordinates" sheet) 1 10 0 10 0 10 249 11384 0 0 0.0147055780339792 0.999122345093909 0.998386555629556 0.999579052676482 0 0 0.30849710781876 0 0 0.30849710781876 0 0 0.30849710781876 0 0 20.5112934421461 1 245.5 609 False False 0 0 20.5112934421461 0 0 0.0147055780339792 0.999122345093909 0.998386555629556 0.999579052676482 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Delamanid Rv2983 p.Gln123Arg Rv2983_p.Gln123Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Delamanid Rv2983 p.Glu105Asp Rv2983_p.Glu105Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 554 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid Rv2983 p.Glu66Gln Rv2983_p.Glu66Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 556 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 54 505 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 72 83 False False 0 0 0 0 0 0 0 0 0 363.375224416517 0 0 0.0660315142444217 0.998023715415019 0.989038460642947 0.999949966058094 1 3) Uncertain significance New Uncertain no 0 +Delamanid Rv2983 p.Gly145Arg Rv2983_p.Gly145Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 560 609 False False 0 0 111.334370311011 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 27 3) Uncertain significance No change no 1 +Delamanid Rv2983 p.Gly155Ser Rv2983_p.Gly155Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 249 11391 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 244.200965863688 1 47 609 False False 0 0 111.334370311011 0 0 0.0147055780339792 0.999736703528172 0.999230730695071 0.999945698645904 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance No change no 1 +Delamanid Rv2983 p.Gly74Arg Rv2983_p.Gly74Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 564 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Delamanid Rv2983 p.Gly76Ser Rv2983_p.Gly76Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 559 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid Rv2983 p.Gly8Asp Rv2983_p.Gly8Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Delamanid Rv2983 p.Ile110Val Rv2983_p.Ile110Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid Rv2983 p.Ile13Leu Rv2983_p.Ile13Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 7 249 11387 0 0 0.0147055780339792 0.999385641565736 0.998734599099098 0.99975296150752 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 566 609 False False 0 0 31.8900809629541 0 0 0.0147055780339792 0.999385641565736 0.998734599099098 0.99975296150752 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 3) Uncertain significance No change no 1 +Delamanid Rv2983 p.Ile59Leu Rv2983_p.Ile59Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 0 9 0 9 249 11385 0 0 0.0147055780339792 0.999210110584518 0.998501075795816 0.999638750670416 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.336267116879942 0 0 23.2953648317795 1 245.5 609 False False 0 0 23.2953648317795 0 0 0.0147055780339792 0.999210110584518 0.998501075795816 0.999638750670416 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 3) Uncertain significance No change no 1 +Delamanid Rv2983 p.Leu125Ile Rv2983_p.Leu125Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 244.222407132781 1 245.5 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 27 3) Uncertain significance No change no 1 +Delamanid Rv2983 p.Leu144Val Rv2983_p.Leu144Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid Rv2983 p.Pro28del Rv2983_p.Pro28del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid Rv2983 p.Pro91Ser Rv2983_p.Pro91Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 249 11392 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 558 609 False False 0 0 244.222407132781 0 0 0.0147055780339792 0.999824469018782 0.99936606710312 0.999978741676894 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Delamanid Rv2983 p.Ter215Argext*? Rv2983_p.Ter215Argext*? 1 stop_lost (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid Rv2983 p.Thr146Ala Rv2983_p.Thr146Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid Rv2983 p.Thr146Ser Rv2983_p.Thr146Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Delamanid Rv2983 p.Thr179Pro Rv2983_p.Thr179Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Delamanid Rv2983 p.Thr191fs Rv2983_p.Thr191fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim New AwRI no 5 +Delamanid Rv2983 p.Val61Ile Rv2983_p.Val61Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 249 11393 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1736.21616988455 1 245.5 609 False False 0 0 1736.21616988455 0 0 0.0147055780339792 0.99991223450939 0.999511100073968 0.999997777972629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB c.1008C>T aftB_c.1008C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1009C>A aftB_c.1009C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1014G>C aftB_c.1014G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 5 9480 35700 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999859963590533 0.999673232250017 0.999954529045718 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.753164556962025 0.0159260191955521 6.73154939272228 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 4 6559 26501 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999849085078287 0.999613643356053 0.999958879281354 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.01010062509528 0.0205075656450505 10.2127021503241 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1026G>A aftB_c.1026G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1029G>C aftB_c.1029G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1039C>T aftB_c.1039C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 12 9479 35693 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.99966391261728 0.999412996653316 0.999826327071809 0.142857142857142 0.0177945154831915 0.428129160909698 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.627580265147519 0.0682070896184037 2.81999711742652 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 10 6558 26495 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999622712695717 0.999306265033238 0.999819061720012 0.166666666666666 0.0208625254600923 0.484137748685967 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.808020738029887 0.0860624002038487 3.79288404060304 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1056C>A aftB_c.1056C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 7 0 9474 35705 0.000738318742748655 0.00029689231210758 0.00152062336565454 1 0.999896689850119 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 5.43056595882186 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 4 0 6556 26505 0.000609756097560975 0.000166162208307701 0.00156047520083291 1 0.999860832946126 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 2.66797681781562 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1059T>C aftB_c.1059T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.105G>C aftB_c.105G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1065T>A aftB_c.1065T>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1083G>A aftB_c.1083G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1086C>T aftB_c.1086C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.88306962025316 0.0319145727646777 36.1783621216076 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1101C>T aftB_c.1101C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1116C>T aftB_c.1116C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 3 9480 35702 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99991597815432 0.999754472342108 0.99998267234027 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.25534458509142 0.0239099774609589 15.6346568618898 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1122G>A aftB_c.1122G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 20 9480 35685 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999439854362134 0.999135032404509 0.999657815983264 0.0476190476190476 0.00120488344836351 0.238159909936821 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.188212025316455 0.00454413367739119 1.17708731774393 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 14 6560 26491 0 0 0.000562171107654053 0.999471797774004 0.999113925067086 0.999711197799087 0 0 0.231635761650116 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.21779664057642 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1128C>T aftB_c.1128C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.114A>G aftB_c.114A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1152T>G aftB_c.1152T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1159C>T aftB_c.1159C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1161G>A aftB_c.1161G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1176G>A aftB_c.1176G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1182C>A aftB_c.1182C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1188T>C aftB_c.1188T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1194C>T aftB_c.1194C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.-11C>G aftB_c.-11C>G 2 upstream_gene_variant 4268847 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB c.1203G>A aftB_c.1203G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.707313928675496 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1203G>T aftB_c.1203G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1209C>T aftB_c.1209C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1218C>T aftB_c.1218C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.10982832991351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1221C>T aftB_c.1221C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1227C>T aftB_c.1227C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1245C>G aftB_c.1245C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1248G>A aftB_c.1248G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1260C>T aftB_c.1260C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1269G>A aftB_c.1269G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1269G>T aftB_c.1269G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1275C>G aftB_c.1275C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1275C>T aftB_c.1275C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1278C>A aftB_c.1278C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1278C>T aftB_c.1278C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1281G>A aftB_c.1281G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1287C>T aftB_c.1287C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1290C>T aftB_c.1290C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 3 9480 35702 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99991597815432 0.999754472342108 0.99998267234027 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.25534458509142 0.0239099774609589 15.6346568618898 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 3 6559 26502 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999886813808715 0.999669257903365 0.999976657677988 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.34685165421558 0.025651688752077 16.7753654027497 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.-12C>T aftB_c.-12C>T 2 upstream_gene_variant 4268848 NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4672 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB c.1300C>A aftB_c.1300C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1311C>G aftB_c.1311C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1311C>T aftB_c.1311C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1317T>C aftB_c.1317T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1320A>G aftB_c.1320A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 4 9480 35701 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999887970872426 0.999713186009257 0.999969475016731 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.941482067510548 0.0191153149568561 9.51304376083015 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 3 6559 26502 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999886813808715 0.999669257903365 0.999976657677988 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.34685165421558 0.025651688752077 16.7753654027497 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1323G>T aftB_c.1323G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1326C>T aftB_c.1326C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1329C>T aftB_c.1329C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1347G>A aftB_c.1347G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1351C>T aftB_c.1351C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1371C>T aftB_c.1371C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1374C>T aftB_c.1374C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.138A>G aftB_c.138A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1407G>A aftB_c.1407G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1416C>G aftB_c.1416C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1419G>A aftB_c.1419G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1431G>A aftB_c.1431G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1434G>T aftB_c.1434G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1455A>C aftB_c.1455A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1455A>G aftB_c.1455A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1458G>A aftB_c.1458G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1461T>C aftB_c.1461T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1467C>T aftB_c.1467C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1485C>T aftB_c.1485C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1491C>T aftB_c.1491C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1494C>T aftB_c.1494C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1497G>A aftB_c.1497G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.-14T>C aftB_c.-14T>C 2 upstream_gene_variant 4268850 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB c.1500C>T aftB_c.1500C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 2 9479 35703 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999943985436213 0.999797670939776 0.99999321630447 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.76653655448887 0.272970929153834 51.9466713138689 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1503T>C aftB_c.1503T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1506C>A aftB_c.1506C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1506C>G aftB_c.1506C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1506C>T aftB_c.1506C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.150C>T aftB_c.150C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1515C>T aftB_c.1515C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1518C>T aftB_c.1518C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1530G>A aftB_c.1530G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1542G>A aftB_c.1542G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1551C>T aftB_c.1551C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1558C>A aftB_c.1558C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.156C>T aftB_c.156C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1572C>G aftB_c.1572C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1572C>T aftB_c.1572C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1575T>G aftB_c.1575T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1581C>A aftB_c.1581C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1599C>T aftB_c.1599C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.707313928675496 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1614C>T aftB_c.1614C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.10982832991351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.40943166615857 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1617C>A aftB_c.1617C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1620C>T aftB_c.1620C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1632G>C aftB_c.1632G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1635G>A aftB_c.1635G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1653C>A aftB_c.1653C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1662C>T aftB_c.1662C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1665C>T aftB_c.1665C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.10982832991351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1686C>T aftB_c.1686C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1695C>A aftB_c.1695C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.-16G>A aftB_c.-16G>A 2 upstream_gene_variant 4268852 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB c.1701A>G aftB_c.1701A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1707C>T aftB_c.1707C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1719G>A aftB_c.1719G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 9 9479 35696 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.99974793446296 0.999521555266748 0.999884733314884 0.181818181818181 0.0228311982999596 0.517755852360172 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.836844017770275 0.0879719531671099 4.04425008799206 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 8 6559 26497 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999698170156574 0.999405361976814 0.999869682578628 0.111111111111111 0.00280913674659921 0.482496514917337 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.504974081414849 0.0113820510464553 3.76768363928727 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.171G>C aftB_c.171G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1734G>A aftB_c.1734G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1740C>A aftB_c.1740C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1740C>T aftB_c.1740C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1746C>A aftB_c.1746C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 38 9481 35667 0 0 0.00038900558066021 0.998935723288054 0.998539486720009 0.99924674779982 0 0 0.0925127614158782 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.383589196493182 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 29 6560 26476 0 0 0.000562171107654053 0.998905866817581 0.998429017222443 0.999267123212173 0 0 0.119444869069502 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.547664524532322 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1750C>T aftB_c.1750C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1755C>T aftB_c.1755C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1761C>T aftB_c.1761C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1767C>T aftB_c.1767C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1770C>T aftB_c.1770C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1776G>A aftB_c.1776G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.177C>A aftB_c.177C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.177C>G aftB_c.177C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1782C>G aftB_c.1782C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1791C>T aftB_c.1791C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1800C>T aftB_c.1800C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1803C>T aftB_c.1803C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.19822685561766 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1806C>T aftB_c.1806C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1812C>T aftB_c.1812C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.76624472573839 0.0479745002090283 294.932792118969 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1824T>C aftB_c.1824T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1830G>A aftB_c.1830G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1833C>G aftB_c.1833C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1839T>C aftB_c.1839T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1854C>G aftB_c.1854C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 9 9481 35696 0 0 0.00038900558066021 0.99974793446296 0.999521555266748 0.999884733314884 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.90786321657339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1860G>A aftB_c.1860G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1869G>A aftB_c.1869G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.76624472573839 0.0479745002090283 294.932792118969 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.1875G>A aftB_c.1875G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 8 9481 35697 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.20624116275339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 6 6560 26499 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.43165838346939 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.198G>A aftB_c.198G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.-19G>A aftB_c.-19G>A 2 upstream_gene_variant 4268855 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB c.-1C>G aftB_c.-1C>G 2 upstream_gene_variant 4268837 NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4664 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB c.-1C>T aftB_c.-1C>T 2 upstream_gene_variant 4268837 1 1 0 1 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 146.529978407112 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 157.179059039538 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 3 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB c.201G>T aftB_c.201G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.225G>T aftB_c.225G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.22C>T aftB_c.22C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.-22G>A aftB_c.-22G>A 2 upstream_gene_variant 4268858 1 5 0 5 0 7 9481 35698 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 0 0 0.409616397225003 0 0 0.521823750104981 0 0 0.409616397225003 0 0 4.10959809458789 0.590981691334869 521.5 4975 False False 0 0 2.61285174975179 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.77947080093164 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 1 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB c.237G>A aftB_c.237G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.243C>T aftB_c.243C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.255C>T aftB_c.255C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.-25T>C aftB_c.-25T>C 2 upstream_gene_variant 4268861 1 61 1 60 4 78 9477 35627 0.000421896424427802 0.000114964157806894 0.00107986688593449 0.997815432012323 0.997274299230959 0.998272818348699 0.048780487804878 0.0134490336528281 0.120211762214449 0.0163934426229508 0.00041495991283974 0.0879881229227452 0.0126582278481012 0.000320427234304267 0.0685199094867721 0.0626552003095212 0.00156453658530241 0.36278587189784 2.14470548829909e-05 20 4975 True False 0.192785231721604 0.0512085810469042 0.513874001225871 0.000105507491031863 2.67121483114821e-06 0.000587708362116832 0.997815432012323 0.997274299230959 0.998272818348699 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 48 1 47 3 63 6557 26442 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 0.997623089983022 0.996959909844479 0.998173048494852 0.0454545454545454 0.00947373856370622 0.127142505911317 0.0208333333333333 0.00052731525342312 0.110696160593152 0.015625 0.000395512514050664 0.0840103264343536 0.0858007846089448 0.00213122936838099 0.502182331111172 0.000454978032447595 24 4087 False False 0 0 0 0 0 0 0 0.192030327458114 0.0385602325156488 0.587717127886264 0.000152485513876181 3.86059150860036e-06 0.000849298834468653 0.997623089983022 0.996959909844479 0.998173048494852 5 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB c.-25T>G aftB_c.-25T>G 2 upstream_gene_variant 4268861 NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4737 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3891 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB c.261C>A aftB_c.261C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.261C>T aftB_c.261C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.273G>A aftB_c.273G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.276G>A aftB_c.276G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.279G>A aftB_c.279G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.27G>T aftB_c.27G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.289C>T aftB_c.289C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 9 9481 35696 0 0 0.00038900558066021 0.99974793446296 0.999521555266748 0.999884733314884 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.90786321657339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 9 6560 26496 0 0 0.000562171107654053 0.999660441426146 0.999355510362951 0.999844720818052 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.04691100627475 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.298C>T aftB_c.298C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 10 9481 35695 0 0 0.00038900558066021 0.999719927181067 0.999484996631079 0.999865686288203 0 0 0.30849710781876 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.67996531074212 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 10 6560 26495 0 0 0.000562171107654053 0.999622712695717 0.999306265033238 0.999819061720012 0 0 0.30849710781876 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.80248078294835 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.-2C>T aftB_c.-2C>T 2 upstream_gene_variant 4268838 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 2 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB c.300G>A aftB_c.300G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.30G>A aftB_c.30G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.30G>T aftB_c.30G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 8 9481 35697 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.20624116275339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.312G>C aftB_c.312G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.312G>T aftB_c.312G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.318C>T aftB_c.318C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 7 9481 35698 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.61285174975179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.321A>C aftB_c.321A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.321A>G aftB_c.321A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.-32G>A aftB_c.-32G>A 2 upstream_gene_variant 4268868 NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4677 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB c.330G>A aftB_c.330G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.76624472573839 0.0479745002090283 294.932792118969 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.336C>T aftB_c.336C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.339T>G aftB_c.339T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.342G>C aftB_c.342G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 7 9479 35698 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999803949026747 0.999596102051779 0.999921173824063 0.222222222222222 0.0281449734778982 0.600093573716312 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.07600259219628 0.109030897238266 5.65147295095111 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 3 6559 26502 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999886813808715 0.999669257903365 0.999976657677988 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.34685165421558 0.025651688752077 16.7753654027497 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.357G>T aftB_c.357G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.360C>A aftB_c.360C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.88306962025316 0.0319145727646777 36.1783621216076 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.360C>T aftB_c.360C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 27 9481 35678 0 0 0.00038900558066021 0.999243803388881 0.998899962900125 0.999501604380895 0 0 0.127702867615432 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.551051070388324 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 23 6560 26482 0 0 0.000562171107654053 0.99913223920015 0.998698215498625 0.999449837068455 0 0 0.148185128915224 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.702513080401621 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.369G>C aftB_c.369G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.36G>C aftB_c.36G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.372A>G aftB_c.372A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.378C>A aftB_c.378C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.378C>T aftB_c.378C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.-37C>T aftB_c.-37C>T 2 upstream_gene_variant 4268873 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB c.381G>A aftB_c.381G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 11 87 9470 35618 0.00116021516717645 0.00057931301275248 0.00207499495108562 0.997563366475283 0.996995276895636 0.998047910152166 0.112244897959183 0.0573823783550178 0.191966999030684 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.475546492857056 0.22887092301288 0.894004870367914 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 4 48 6556 26457 0.000609756097560975 0.000166162208307701 0.00156047520083291 0.998189020939445 0.997599613132576 0.998664434411983 0.0769230769230769 0.0213565864913836 0.185396604383411 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.336294996949359 0.0880619954535106 0.918968386326713 NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.384G>A aftB_c.384G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.387A>G aftB_c.387A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.393C>G aftB_c.393C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.39C>T aftB_c.39C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.-3C>A aftB_c.-3C>A 2 upstream_gene_variant 4268839 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4718 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB c.-3C>T aftB_c.-3C>T 2 upstream_gene_variant 4268839 NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4685 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3853 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 1 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB c.3G>A aftB_c.3G>A 2 initiator_codon_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.402C>T aftB_c.402C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.408C>T aftB_c.408C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.-40G>A aftB_c.-40G>A 2 upstream_gene_variant 4268876 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB c.427C>T aftB_c.427C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.42C>T aftB_c.42C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.438C>T aftB_c.438C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.444G>A aftB_c.444G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.444G>C aftB_c.444G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.-45C>T aftB_c.-45C>T 2 upstream_gene_variant 4268881 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB c.45G>A aftB_c.45G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.-46G>A aftB_c.-46G>A 2 upstream_gene_variant 4268882 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB c.477A>G aftB_c.477A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.486G>T aftB_c.486G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.492C>G aftB_c.492C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.495C>T aftB_c.495C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.501C>T aftB_c.501C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.516C>G aftB_c.516C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.519C>A aftB_c.519C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.528C>A aftB_c.528C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.528C>T aftB_c.528C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.-52C>T aftB_c.-52C>T 2 upstream_gene_variant 4268888 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB c.531C>T aftB_c.531C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 6 9480 35699 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99983195630864 0.999634275787128 0.999938328510354 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.627619549929676 0.0136468000350686 5.17448319653473 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 5 6559 26500 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999811356347858 0.999559824020536 0.9999387451734 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.808050007623113 0.0170817619606711 7.22310074751644 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.546C>T aftB_c.546C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.549G>A aftB_c.549G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.558G>A aftB_c.558G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.561G>A aftB_c.561G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.564A>G aftB_c.564A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.571C>T aftB_c.571C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.573G>A aftB_c.573G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.576C>T aftB_c.576C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.-57C>T aftB_c.-57C>T 2 upstream_gene_variant 4268893 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB c.-58G>T aftB_c.-58G>T 2 upstream_gene_variant 4268894 NA 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4706 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3867 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB c.-59T>C aftB_c.-59T>C 2 upstream_gene_variant 4268895 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB c.603G>A aftB_c.603G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 39 9480 35666 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.998907716006161 0.998507111173478 0.999223167585189 0.025 0.000632744932049419 0.131585858482765 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.0964675971005084 0.00238571908282842 0.570243324245325 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 21 6559 26484 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999207696661007 0.998789133813842 0.999509486956307 0.0454545454545454 0.00115014752657357 0.228444397667633 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.19227669723172 0.00465235755738179 1.19600335948603 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.60G>A aftB_c.60G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.615G>T aftB_c.615G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.627C>G aftB_c.627C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.633G>A aftB_c.633G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.634C>T aftB_c.634C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.636G>A aftB_c.636G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.651C>T aftB_c.651C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.658T>C aftB_c.658T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.10982832991351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.-66G>A aftB_c.-66G>A 2 upstream_gene_variant 4268902 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4707 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3868 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB c.678C>A aftB_c.678C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 1 9478 35704 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999971992718106 0.999843963402622 0.999999290917266 0.75 0.194120449683243 0.99369053679029 NA NA NA NA NA NA NA NA NA NA NA NA False False 11.3011183794049 0.90722384791697 591.183089908516 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.681C>T aftB_c.681C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.696C>T aftB_c.696C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 13 9481 35692 0 0 0.00038900558066021 0.999635905335387 0.999377467513205 0.999806121137399 0 0 0.24705263800047 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.2354962611609 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 12 6560 26493 0 0 0.000562171107654053 0.999547255234861 0.999209279704825 0.999766038988972 0 0 0.264648469397051 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.45386850159099 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.699A>C aftB_c.699A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.700C>T aftB_c.700C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 13 9479 35692 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999635905335387 0.999377467513205 0.999806121137399 0.133333333333333 0.0165759134400836 0.404602696603372 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.579288629926882 0.0634555870290756 2.55961742801428 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 13 6558 26492 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999509526504433 0.999161421428146 0.999738818498366 0.133333333333333 0.0165759134400836 0.404602696603372 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.621484035939662 0.0680730148097731 2.74624536978086 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.702G>C aftB_c.702G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 24 9481 35681 0 0 0.00038900558066021 0.999327825234561 0.999000021245735 0.999569278960296 0 0 0.142473597722525 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.625436057966667 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 24 6560 26481 0 0 0.000562171107654053 0.999094510469722 0.998653000996664 0.999419752318005 0 0 0.142473597722525 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.67091714745426 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.703C>T aftB_c.703C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.-70C>A aftB_c.-70C>A 2 upstream_gene_variant 4268906 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB c.720G>T aftB_c.720G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.721C>T aftB_c.721C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.726C>T aftB_c.726C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.-72C>G aftB_c.-72C>G 2 upstream_gene_variant 4268908 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4700 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3863 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB c.735C>G aftB_c.735C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.738G>A aftB_c.738G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.741C>A aftB_c.741C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 7 9478 35698 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999803949026747 0.999596102051779 0.999921173824063 0.3 0.0667395111777345 0.652452850059997 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.61417417779519 0.269289687209695 7.07224620508753 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.744C>T aftB_c.744C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.753G>A aftB_c.753G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.-75G>A aftB_c.-75G>A 2 upstream_gene_variant 4268911 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB c.-75G>T aftB_c.-75G>T 2 upstream_gene_variant 4268911 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB c.768C>T aftB_c.768C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.786G>A aftB_c.786G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.789G>A aftB_c.789G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.792C>T aftB_c.792C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.796C>T aftB_c.796C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 12 12 9469 35693 0.0012656892732834 0.000654165731961641 0.0022098595784263 0.99966391261728 0.999412996653316 0.999826327071809 0.5 0.291241779836211 0.708758220163788 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.76945823212588 1.54830982876592 9.17573502830259 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 12 12 6548 26493 0.00182926829268292 0.000945555636841848 0.00319318105848117 0.999547255234861 0.999209279704825 0.999766038988972 0.5 0.291241779836211 0.708758220163788 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.04596823457544 1.66159113455091 9.85082222399566 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.7C>A aftB_c.7C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.-7T>C aftB_c.-7T>C 2 upstream_gene_variant 4268843 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4723 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3882 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB c.807G>A aftB_c.807G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.813G>A aftB_c.813G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.-81C>T aftB_c.-81C>T 2 upstream_gene_variant 4268917 NA 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4644 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3819 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB c.822G>A aftB_c.822G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.828G>T aftB_c.828G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.-82G>A aftB_c.-82G>A 2 upstream_gene_variant 4268918 1 1 0 1 2 8 9479 35697 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999775941744853 0.999558563909973 0.999903262744512 0.2 0.0252107263268333 0.556095462307641 0 0 0.975 0 0 0.369416647552819 0 0 146.54034636079 1 2818.5 4975 False False 0.941475894081654 0.0973783182815292 4.71874266187613 0 0 0.000389087642036349 0.999775941744853 0.999558563909973 0.999903262744512 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 8 6558 26497 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999698170156574 0.999405361976814 0.999869682578628 0.2 0.0252107263268333 0.556095462307641 0 0 0.975 0 0 0.369416647552819 0 0 157.197287103955 1 2276.5 4087 False False 0 0 0 0 0 0 0 1.01010216529429 0.104463368269269 5.06308595441747 0 0 0.00056234250533983 0.999698170156574 0.999405361976814 0.999869682578628 1 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB c.834G>A aftB_c.834G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 31 9480 35674 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999131774261308 0.998767847272761 0.999410008882762 0.03125 0.000790868597952557 0.162170994181511 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.121389682863753 0.00298198347492451 0.728574598119971 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 30 6559 26475 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.998868138087153 0.998384587759283 0.999236211285303 0.032258064516129 0.000816370071846613 0.167021116230227 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.134547949382527 0.00330120224870607 0.80969107520406 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.838T>C aftB_c.838T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.84T>G aftB_c.84T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 25 7 9456 35698 0.00263685265267376 0.00170713654135637 0.00389007034128332 0.999803949026747 0.999596102051779 0.999921173824063 0.78125 0.600271736287892 0.90722846771528 NA NA NA NA NA NA NA NA NA NA NA NA False False 13.4827471597776 5.66639740566925 36.9242806467943 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 9 0 6551 26505 0.00137195121951219 0.000627529309645025 0.00260278604702639 1 0.999860832946126 1 1 0.663732883120057 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 7.98180213517408 Inf NA NA NA NA NA NA 36 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.-85C>T aftB_c.-85C>T 2 upstream_gene_variant 4268921 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4673 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3841 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB c.861G>A aftB_c.861G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.861G>C aftB_c.861G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.873T>C aftB_c.873T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.873T>G aftB_c.873T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.876C>A aftB_c.876C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.-88C>T aftB_c.-88C>T 2 upstream_gene_variant 4268924 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB c.894C>T aftB_c.894C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.-8A>G aftB_c.-8A>G 2 upstream_gene_variant 4268844 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB c.-8A>T aftB_c.-8A>T 2 upstream_gene_variant 4268844 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB c.903G>A aftB_c.903G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.906C>T aftB_c.906C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 9478 35705 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 1 0.999896689850119 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.55639137151076 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.909G>A aftB_c.909G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.909G>C aftB_c.909G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 3 9480 35702 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99991597815432 0.999754472342108 0.99998267234027 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.25534458509142 0.0239099774609589 15.6346568618898 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.912G>A aftB_c.912G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 3 9480 35702 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99991597815432 0.999754472342108 0.99998267234027 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.25534458509142 0.0239099774609589 15.6346568618898 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.912G>T aftB_c.912G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.927G>A aftB_c.927G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.930C>T aftB_c.930C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.948C>G aftB_c.948C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.969G>A aftB_c.969G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol aftB c.-9T>C aftB_c.-9T>C 2 upstream_gene_variant 4268845 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4696 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB LoF aftB_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ala115Thr aftB_p.Ala115Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4741 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3894 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ala115Val aftB_p.Ala115Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ala120Thr aftB_p.Ala120Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4689 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3857 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ala127Thr aftB_p.Ala127Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ala127Val aftB_p.Ala127Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ala131Gly aftB_p.Ala131Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ala146Val aftB_p.Ala146Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4686 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3854 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ala174Thr aftB_p.Ala174Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 157.21479794295 1 1103 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ala174Val aftB_p.Ala174Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 3.76624472573839 0.0479745002090283 294.932792118969 0.375621806809355 335.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 4.04085988717792 0.0514701624188962 316.380494544091 0.35743759524028 195 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ala176Val aftB_p.Ala176Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ala196Glu aftB_p.Ala196Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ala203Val aftB_p.Ala203Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ala204Thr aftB_p.Ala204Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ala204Val aftB_p.Ala204Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4683 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3852 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ala216Val aftB_p.Ala216Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ala265Thr aftB_p.Ala265Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4647 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ala295Thr aftB_p.Ala295Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.19822685561766 0.354697857676227 290 4975 False False 0 0 3.19822685561766 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ala302Thr aftB_p.Ala302Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 157.21479794295 1 1103 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ala302Val aftB_p.Ala302Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4719 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3877 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ala304Glu aftB_p.Ala304Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ala304Ser aftB_p.Ala304Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.096562813829025 Inf 0.209821626167397 198.5 4975 False False Inf 0.096562813829025 Inf 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ala304Thr aftB_p.Ala304Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ala304Val aftB_p.Ala304Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ala310Thr aftB_p.Ala310Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4669 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3838 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ala310Val aftB_p.Ala310Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 7 9481 35698 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 0 0 0.409616397225003 0 0 0.707598226178713 0 0 0.409616397225003 0 0 9.11450885373478 1 2818.5 4975 False False 0 0 2.61285174975179 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 9.77910191708565 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ala323Gly aftB_p.Ala323Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4645 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ala341Pro aftB_p.Ala341Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ala348Asp aftB_p.Ala348Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 12 0 12 1 14 9480 35691 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999607898053494 0.999342206985133 0.999785618166341 0.0666666666666666 0.0016864302413527 0.319484566578303 0 0 0.264648469397051 0 0 0.231635761650116 0 0 1.35525850789377 0.0835934030832631 114 4975 False False 0.268919529837251 0.00636280625779473 1.7679218975043 0 0 0.00038904660702099 0.999607898053494 0.999342206985133 0.999785618166341 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 12 0 12 1 13 6559 26492 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999509526504433 0.999161421428146 0.999738818498366 0.0714285714285714 0.00180678065912538 0.338684489931821 0 0 0.264648469397051 0 0 0.24705263800047 0 0 1.45403485792218 0.14075966177921 111 4087 False False 0 0 0 0 0 0 0 0.310694641537757 0.0073132274312288 2.06928814207562 0 0 0.000562256793434776 0.999509526504433 0.999161421428146 0.999738818498366 4 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ala389Gly aftB_p.Ala389Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ala389Pro aftB_p.Ala389Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ala389Val aftB_p.Ala389Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.10982832991351 0.590980565810755 492 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.40943166615857 0.590385352956204 278 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ala399Val aftB_p.Ala399Val 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4674 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3842 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ala417Asp aftB_p.Ala417Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0615661524565 1 2818.5 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ala417Ser aftB_p.Ala417Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ala426Val aftB_p.Ala426Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4729 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3885 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ala441Thr aftB_p.Ala441Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4708 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3869 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ala449dup aftB_p.Ala449dup 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ala449Glu aftB_p.Ala449Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ala449Thr aftB_p.Ala449Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 2 3 9479 35702 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.99991597815432 0.999754472342108 0.99998267234027 0.4 0.0527449505263169 0.853367200365326 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.0631165181962 1 2818.5 4975 False False 2.51095403875232 0.209684820120099 21.9222407664312 0 0 0.000389087642036349 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ala449Val aftB_p.Ala449Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ala473Val aftB_p.Ala473Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 146.529978407112 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 157.179059039538 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ala485Glu aftB_p.Ala485Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.058895521352 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 21.5173342675905 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ala516Glu aftB_p.Ala516Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4653 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3826 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ala516Thr aftB_p.Ala516Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4738 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3892 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ala516Val aftB_p.Ala516Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4701 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3864 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ala539Val aftB_p.Ala539Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4720 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3878 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ala564Val aftB_p.Ala564Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4712 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3873 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ala565Asp aftB_p.Ala565Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4697 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ala565Thr aftB_p.Ala565Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ala580Asp aftB_p.Ala580Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ala580Ser aftB_p.Ala580Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ala83Thr aftB_p.Ala83Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4721 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3879 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Arg111Trp aftB_p.Arg111Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Arg113His aftB_p.Arg113His 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Arg114Trp aftB_p.Arg114Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4690 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Arg132Leu aftB_p.Arg132Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Arg210Gly aftB_p.Arg210Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4650 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3823 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Arg24Ser aftB_p.Arg24Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Arg25Cys aftB_p.Arg25Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Arg25Ser aftB_p.Arg25Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Arg284Cys aftB_p.Arg284Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 146.529978407112 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3846 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Arg284His aftB_p.Arg284His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4660 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3833 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Arg284Pro aftB_p.Arg284Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Arg291Cys aftB_p.Arg291Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4709 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3870 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Arg291Gly aftB_p.Arg291Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Arg291His aftB_p.Arg291His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4713 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3874 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Arg300Trp aftB_p.Arg300Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 4 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Arg303Gln aftB_p.Arg303Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0615661524565 1 2818.5 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3880 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Arg39His aftB_p.Arg39His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Arg3Trp aftB_p.Arg3Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Arg401Gly aftB_p.Arg401Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Arg401Leu aftB_p.Arg401Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Arg411His aftB_p.Arg411His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Arg412His aftB_p.Arg412His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4678 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3847 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Arg467Leu aftB_p.Arg467Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.19822685561766 0.354697857676227 290 4975 False False 0 0 3.19822685561766 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 6560 26499 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.43165838346939 0.605981932438924 311.5 4087 False False 0 0 0 0 0 0 0 0 0 3.43165838346939 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 1 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Arg503Gln aftB_p.Arg503Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Arg572Gln aftB_p.Arg572Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Arg579His aftB_p.Arg579His 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Arg599His aftB_p.Arg599His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Arg599Leu aftB_p.Arg599Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Arg601Cys aftB_p.Arg601Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.058895521352 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Arg626Trp aftB_p.Arg626Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Asn259Asp aftB_p.Asn259Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 11 9481 35694 0 0 0.00038900558066021 0.999691919899173 0.999448826618347 0.999846197812 0 0 0.284914152918154 0 0 0.4592581264399 0 0 0.284914152918154 0 0 3.19777851945731 0.354685202970498 270 4975 False False 0 0 1.50034693324555 0 0 0.00038900558066021 0.999691919899173 0.999448826618347 0.999846197812 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 7 6560 26498 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 0 0 0.409616397225003 0 0 0.521823750104981 0 0 0.409616397225003 0 0 4.40909889007489 0.590385105661229 256 4087 False False 0 0 0 0 0 0 0 0 0 2.80327602229365 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 1 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Asn259His aftB_p.Asn259His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Asn40Asp aftB_p.Asn40Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 32 0 32 1 36 9480 35669 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.998991737851841 0.998604410736722 0.999293728778475 0.027027027027027 0.000684031024694665 0.141603095611158 0 0 0.108881160679352 0 0 0.0973937559144919 0 0 0.459856394008284 0.00078892638710392 28 4975 False False 0.104515353961556 0.00257908995979944 0.620883727326282 0 0 0.00038904660702099 0.998991737851841 0.998604410736722 0.999293728778475 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 21 0 21 0 23 6560 26482 0 0 0.000562171107654053 0.99913223920015 0.998698215498625 0.999449837068455 0 0 0.148185128915224 0 0 0.161097615219079 0 0 0.148185128915224 0 0 0.775486515839429 0.0134214614484193 43.5 4087 False False 0 0 0 0 0 0 0 0 0 0.702513080401621 0 0 0.000562171107654053 0.99913223920015 0.998698215498625 0.999449837068455 22 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Asn40Ser aftB_p.Asn40Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Asn45Ser aftB_p.Asn45Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4725 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3884 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Asn50Ser aftB_p.Asn50Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4665 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Asn576Ser aftB_p.Asn576Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4730 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3886 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Asp248Gly aftB_p.Asp248Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 10 9481 35695 0 0 0.00038900558066021 0.999719927181067 0.999484996631079 0.999865686288203 0 0 0.30849710781876 0 0 0.4592581264399 0 0 0.30849710781876 0 0 3.1978681866364 0.35468773330874 271 4975 False False 0 0 1.67996531074212 0 0 0.00038900558066021 0.999719927181067 0.999484996631079 0.999865686288203 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 7 6560 26498 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 0 0 0.409616397225003 0 0 0.521823750104981 0 0 0.409616397225003 0 0 4.40909889007489 0.590385105661229 256 4087 False False 0 0 0 0 0 0 0 0 0 2.80327602229365 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 2 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Asp359Asn aftB_p.Asp359Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4691 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3858 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Asp359del aftB_p.Asp359del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Asp397Glu aftB_p.Asp397Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Asp397Gly aftB_p.Asp397Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4677 8294 4804 27411 0.493302394262208 0.483189446667565 0.503419458808209 0.767707603977034 0.763291675166883 0.772079949060664 0.360573587233058 0.352303782728968 0.368905991375288 NA NA NA 0 0 0.000444665931252557 NA NA NA NA 4661 4975 False True 3.21754937258899 3.06851420848037 3.3737233485584 0 0 0.000767581913894709 0.767707603977034 0.763291675166883 0.772079949060664 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 3363 5235 3197 21270 0.51265243902439 0.500477265466717 0.524816357348991 0.802490096208262 0.797645282088562 0.807268506636278 0.391137473831123 0.380802560391416 0.401546213465966 NA NA NA 0 0 0.000704408798845249 NA NA NA NA 3834 4087 False True 0 1 1 0 0 0 0 4.27400508893993 4.03518543369868 4.52649809014104 0 0 0.00115319113341697 0.802490096208262 0.797645282088562 0.807268506636278 3163 5) Not assoc w R New NotAwR yes 5 +Ethambutol aftB p.Asp398Glu aftB_p.Asp398Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12104088004766 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 2 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Asp428Tyr aftB_p.Asp428Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.19822685561766 0.354697857676227 290 4975 False False 0 0 3.19822685561766 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12104088004766 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Asp431Tyr aftB_p.Asp431Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Asp461Gly aftB_p.Asp461Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Asp535Ala aftB_p.Asp535Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Asp555Glu aftB_p.Asp555Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4726 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Asp619Ala aftB_p.Asp619Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Cys157Tyr aftB_p.Cys157Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Cys613Trp aftB_p.Cys613Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Gln160Glu aftB_p.Gln160Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Gln169Pro aftB_p.Gln169Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4646 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3820 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 4 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Gln322Glu aftB_p.Gln322Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 30 2 28 24 28 9457 35677 0.00253137854656681 0.00162255461135746 0.00376416417214661 0.999215796106988 0.998866804929334 0.999478840936165 0.461538461538461 0.322310318173598 0.605301770888142 0.0666666666666666 0.00817813446065631 0.220735401522961 0.0666666666666666 0.00817813446065631 0.220735401522961 0.269467816734391 0.0311075452937027 1.0689437167867 0.0692132403613261 106 4975 False False 3.2336138008127 1.79324443172558 5.7885201722633 0.000211438841315149 2.56072503821586e-05 0.000763578883760183 0.999215796106988 0.998866804929334 0.999478840936165 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 6557 26505 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 1 0.999860832946126 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3896 4087 False False 0 0 0 0 0 0 0 Inf 1.66990152933523 Inf 0 0 0.000562428243381166 1 0.999860832946126 1 6 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Gln483His aftB_p.Gln483His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4739 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Gln556Arg aftB_p.Gln556Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Gln557Pro aftB_p.Gln557Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 0 11 9481 35694 0 0 0.00038900558066021 0.999691919899173 0.999448826618347 0.999846197812 0 0 0.284914152918154 0 0 0.369416647552819 0 0 0.284914152918154 0 0 2.20605564927831 0.217673629700269 220.5 4975 False False 0 0 1.50034693324555 0 0 0.00038900558066021 0.999691919899173 0.999448826618347 0.999846197812 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 0 11 6560 26494 0 0 0.000562171107654053 0.999584983965289 0.999257543293353 0.999792807866341 0 0 0.284914152918154 0 0 0.369416647552819 0 0 0.284914152918154 0 0 2.36668589340524 0.369996434988908 232 4087 False False 0 0 0 0 0 0 0 0 0 1.60965686204705 0 0 0.000562171107654053 0.999584983965289 0.999257543293353 0.999792807866341 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Gln561Arg aftB_p.Gln561Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 10 40 9471 35665 0.0010547410610695 0.00050590153672643 0.00193884812290577 0.998879708724268 0.998474790382045 0.999199530618593 0.2 0.100302237472571 0.337183108383488 NA NA NA 0 0 0.0880973028788023 NA NA NA NA 4736 4975 False False 0.941426459719142 0.41966099015048 1.91655793538245 0 0 0.000389416234052975 0.998879708724268 0.998474790382045 0.999199530618593 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 8 24 6552 26481 0.00121951219512195 0.000526641184096925 0.00240150352406598 0.999094510469722 0.998653000996664 0.999419752318005 0.25 0.114616005102588 0.434049374922242 NA NA NA 0 0 0.142473597722525 NA NA NA NA 3890 4087 False False 0 0 0 0 0 0 0 1.34722222222222 0.522956485063807 3.10149418873267 0 0 0.000562857326050777 0.999094510469722 0.998653000996664 0.999419752318005 7 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Glu366Lys aftB_p.Glu366Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Glu447Lys aftB_p.Glu447Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12104088004766 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Glu519Asp aftB_p.Glu519Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Glu53Asp aftB_p.Glu53Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Glu563Gly aftB_p.Glu563Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 10 40 9471 35665 0.0010547410610695 0.00050590153672643 0.00193884812290577 0.998879708724268 0.998474790382045 0.999199530618593 0.2 0.100302237472571 0.337183108383488 NA NA NA 0 0 0.0880973028788023 NA NA NA NA 4648 4975 False False 0.941426459719142 0.41966099015048 1.91655793538245 0 0 0.000389416234052975 0.998879708724268 0.998474790382045 0.999199530618593 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 8 24 6552 26481 0.00121951219512195 0.000526641184096925 0.00240150352406598 0.999094510469722 0.998653000996664 0.999419752318005 0.25 0.114616005102588 0.434049374922242 NA NA NA 0 0 0.142473597722525 NA NA NA NA 3821 4087 False False 0 0 0 0 0 0 0 1.34722222222222 0.522956485063807 3.10149418873267 0 0 0.000562857326050777 0.999094510469722 0.998653000996664 0.999419752318005 7 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Glu596Lys aftB_p.Glu596Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 12 9481 35693 0 0 0.00038900558066021 0.99966391261728 0.999412996653316 0.999826327071809 0 0 0.264648469397051 0 0 0.4592581264399 0 0 0.264648469397051 0 0 3.1976888523047 0.354682672933786 269 4975 False False 0 0 1.35519147325258 0 0 0.00038900558066021 0.99966391261728 0.999412996653316 0.999826327071809 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 11 6560 26494 0 0 0.000562171107654053 0.999584983965289 0.999257543293353 0.999792807866341 0 0 0.284914152918154 0 0 0.521823750104981 0 0 0.284914152918154 0 0 4.40843333793161 0.590384616580946 251 4087 False False 0 0 0 0 0 0 0 0 0 1.60965686204705 0 0 0.000562171107654053 0.999584983965289 0.999257543293353 0.999792807866341 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Glu627Asp aftB_p.Glu627Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.19822685561766 0.354697857676227 290 4975 False False 0 0 3.19822685561766 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12104088004766 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Gly103Ala aftB_p.Gly103Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Gly103Cys aftB_p.Gly103Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 10 0 10 0 10 9481 35695 0 0 0.00038900558066021 0.999719927181067 0.999484996631079 0.999865686288203 0 0 0.30849710781876 0 0 0.30849710781876 0 0 0.30849710781876 0 0 1.67996531074212 0.134582133412278 140.5 4975 False False 0 0 1.67996531074212 0 0 0.00038900558066021 0.999719927181067 0.999484996631079 0.999865686288203 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 7 6560 26498 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 2.80327602229365 0.357905531825047 211.5 4087 False False 0 0 0 0 0 0 0 0 0 2.80327602229365 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Gly103Ser aftB_p.Gly103Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Gly173Cys aftB_p.Gly173Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 2 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Gly180Ala aftB_p.Gly180Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Gly18Asp aftB_p.Gly18Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Gly193Cys aftB_p.Gly193Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Gly194Ala aftB_p.Gly194Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 1 9479 35704 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999971992718106 0.999843963402622 0.999999290917266 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 4692 4975 False False 7.53328410169849 0.392120325718966 443.147628387906 0 0 0.000389087642036349 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 1 6558 26504 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999962271269571 0.999789807096406 0.999999044791703 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 3859 4087 False False 0 0 0 0 0 0 0 8.08295211954864 0.420719628662148 475.373667785977 0 0 0.00056234250533983 0.999962271269571 0.999789807096406 0.999999044791703 2 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Gly218Ala aftB_p.Gly218Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4679 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3848 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Gly299Ser aftB_p.Gly299Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Gly331Ser aftB_p.Gly331Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4675 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3843 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Gly351Trp aftB_p.Gly351Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.10982832991351 0.590980565810755 492 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12104088004766 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Gly381Val aftB_p.Gly381Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Gly384Cys aftB_p.Gly384Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4693 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Gly394Asp aftB_p.Gly394Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Gly396Val aftB_p.Gly396Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 2 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Gly46Val aftB_p.Gly46Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Gly52Asp aftB_p.Gly52Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Gly52Ser aftB_p.Gly52Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 8 9481 35697 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 0 0 0.369416647552819 0 0 0.409616397225003 0 0 0.369416647552819 0 0 2.61277856511022 0.357639330631355 317 4975 False False 0 0 2.20624116275339 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 8 6560 26497 0 0 0.000562171107654053 0.999698170156574 0.999405361976814 0.999869682578628 0 0 0.369416647552819 0 0 0.409616397225003 0 0 0.369416647552819 0 0 2.80317025491206 0.357904627019103 207 4087 False False 0 0 0 0 0 0 0 0 0 2.36695385477914 0 0 0.000562171107654053 0.999698170156574 0.999405361976814 0.999869682578628 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Gly549Ala aftB_p.Gly549Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Gly549Ser aftB_p.Gly549Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Gly614Arg aftB_p.Gly614Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Gly614Glu aftB_p.Gly614Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 13 0 13 0 16 9481 35689 0 0 0.00038900558066021 0.999551883489707 0.999272388596077 0.99974384169233 0 0 0.205907214207822 0 0 0.24705263800047 0 0 0.205907214207822 0 0 1.23539240318249 0.0841532311692013 123.5 4975 False False 0 0 0.976295497466411 0 0 0.00038900558066021 0.999551883489707 0.999272388596077 0.99974384169233 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 13 0 13 0 16 6560 26489 0 0 0.000562171107654053 0.999396340313148 0.99901987910474 0.999654918214049 0 0 0.205907214207822 0 0 0.24705263800047 0 0 0.205907214207822 0 0 1.32533805387628 0.0853030776503869 80.5 4087 False False 0 0 0 0 0 0 0 0 0 1.047384092264 0 0 0.000562171107654053 0.999396340313148 0.99901987910474 0.999654918214049 1 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Gly620Arg aftB_p.Gly620Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Gly622fs aftB_p.Gly622fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Gly622Val aftB_p.Gly622Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4649 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3822 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Gly70Ser aftB_p.Gly70Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 9 0 9 1 9 9480 35696 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99974793446296 0.999521555266748 0.999884733314884 0.1 0.00252857854446178 0.445016117028195 0 0 0.336267116879942 0 0 0.336267116879942 0 0 1.90806450507518 0.219221837803997 240.5 4975 False False 0.418377871542428 0.00954775074807024 3.01988679231401 0 0 0.00038904660702099 0.99974793446296 0.999521555266748 0.999884733314884 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 1 9 6559 26496 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999660441426146 0.999355510362951 0.999844720818052 0.1 0.00252857854446178 0.445016117028195 0 0 0.336267116879942 0 0 0.336267116879942 0 0 2.04722321283529 0.220137297273472 170 4087 False False 0 0 0 0 0 0 0 0.448848909894801 0.0102423495192947 3.24032619577018 0 0 0.000562256793434776 0.999660441426146 0.999355510362951 0.999844720818052 1 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Gly74Ala aftB_p.Gly74Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Gly75Arg aftB_p.Gly75Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4655 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3828 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 2 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.His422Arg aftB_p.His422Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4656 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3829 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.His422Pro aftB_p.His422Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4702 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3865 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.His523Tyr aftB_p.His523Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4687 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3855 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.His585Gln aftB_p.His585Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4666 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.His585Tyr aftB_p.His585Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.His593Tyr aftB_p.His593Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ile126Thr aftB_p.Ile126Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ile126Val aftB_p.Ile126Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 12 1 11 1 17 9480 35688 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999523876207814 0.999237788774316 0.999722616660517 0.0555555555555555 0.00140555616736942 0.272943599673368 0.0833333333333333 0.00210759323186022 0.384796165150944 0.0555555555555555 0.00140555616736942 0.272943599673368 0.34223245109321 0.00795358605552605 2.35532077422733 0.480145673878831 347 4975 False False 0.221444527177959 0.00530179747390557 1.41363359947962 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999523876207814 0.999237788774316 0.999722616660517 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 1 10 1 16 6559 26489 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999396340313148 0.99901987910474 0.999654918214049 0.0588235294117647 0.00148817439126663 0.28688939666722 0.0909090909090909 0.00229897221381426 0.412779916988382 0.0588235294117647 0.00148817439126663 0.28688939666722 0.403857295319408 0.00930800696039065 2.83981037498919 0.704120260680728 336 4087 False False 0 0 0 0 0 0 0 0.25241080957463 0.0060216847241531 1.62536129194261 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999396340313148 0.99901987910474 0.999654918214049 3 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ile202Val aftB_p.Ile202Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ile213Met aftB_p.Ile213Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ile315Thr aftB_p.Ile315Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ile327Val aftB_p.Ile327Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 7 208 9474 35497 0.000738318742748655 0.00029689231210758 0.00152062336565454 0.994174485366195 0.993329542123844 0.994937448009131 0.0325581395348837 0.0131883574193543 0.0659289150002143 NA NA NA 0 0 0.0175786579006307 NA NA NA NA 4694 4975 False True 0.126093580000324 0.0500737957285804 0.264594313302464 0 0 0.000389292947027732 0.994174485366195 0.993329542123844 0.994937448009131 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 6 194 6554 26311 0.000914634146341463 0.000335726224038477 0.00198970246660848 0.992680626296925 0.991579690978022 0.993671370815948 0.03 0.0110874556722547 0.064150626705027 NA NA NA 0 0 0.0188352008498959 NA NA NA NA 3860 4087 False True 1 1 1 0 0 0 0 0.124159638089904 0.0449956460408578 0.27539540465999 0 0 0.000562685614442453 0.992680626296925 0.991579690978022 0.993671370815948 15 5) Not assoc w R New NotAwR yes 5 +Ethambutol aftB p.Ile353Thr aftB_p.Ile353Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 5.70499352101301 0.585896604883905 379.5 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ile355Val aftB_p.Ile355Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4667 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ile407Val aftB_p.Ile407Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 0 8 9481 35697 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 2.20624116275339 0.217681019156043 228.5 4975 False False 0 0 2.20624116275339 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 7 6560 26498 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 2.80327602229365 0.357905531825047 211.5 4087 False False 0 0 0 0 0 0 0 0 0 2.80327602229365 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Leu105Ser aftB_p.Leu105Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Leu118Pro aftB_p.Leu118Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Leu145Phe aftB_p.Leu145Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Leu151Phe aftB_p.Leu151Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 13 0 13 2 13 9479 35692 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999635905335387 0.999377467513205 0.999806121137399 0.133333333333333 0.0165759134400836 0.404602696603372 0 0 0.24705263800047 0 0 0.24705263800047 0 0 1.23575702991627 0.0841515278867377 120 4975 False False 0.579288629926882 0.0634555870290756 2.55961742801428 0 0 0.000389087642036349 0.999635905335387 0.999377467513205 0.999806121137399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 12 0 12 2 12 6558 26493 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999547255234861 0.999209279704825 0.999766038988972 0.142857142857142 0.0177945154831915 0.428129160909698 0 0 0.264648469397051 0 0 0.264648469397051 0 0 1.45431073414105 0.140752094061631 109 4087 False False 0 0 0 0 0 0 0 0.67329978652028 0.0731710351378314 3.02558569565248 0 0 0.00056234250533983 0.999547255234861 0.999209279704825 0.999766038988972 4 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Leu162Arg aftB_p.Leu162Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Leu16Arg aftB_p.Leu16Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Leu16Pro aftB_p.Leu16Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Leu172Phe aftB_p.Leu172Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 12 0 12 0 12 9481 35693 0 0 0.00038900558066021 0.99966391261728 0.999412996653316 0.999826327071809 0 0 0.264648469397051 0 0 0.264648469397051 0 0 0.264648469397051 0 0 1.35519147325258 0.0835905265175333 111 4975 False False 0 0 1.35519147325258 0 0 0.00038900558066021 0.99966391261728 0.999412996653316 0.999826327071809 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 1 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Leu266Pro aftB_p.Leu266Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 1 5 8 42 9473 35663 0.000843792848855605 0.000364358012393849 0.00166192766222289 0.998823694160481 0.99841030518573 0.999152094778215 0.16 0.0717007671832861 0.29112630659511 0.166666666666666 0.00421074451448947 0.641234578997674 0.0232558139534883 0.000588612931593182 0.122890482701339 0.752939934550828 0.015921269501418 6.72953919750168 1 1480 4975 False False 0.71708565195317 0.290667395550434 1.54682649475299 0.000105552037154317 2.67234263830968e-06 0.000587956437510075 0.998823694160481 0.99841030518573 0.999152094778215 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 1 4 7 36 6553 26469 0.0010670731707317 0.000429122972600259 0.00219733487653492 0.998641765704584 0.998120122196907 0.999048533698614 0.162790697674418 0.0680520944614691 0.307010872364909 0.2 0.00505076337946806 0.716417936118089 0.027027027027027 0.000684031024694665 0.141603095611158 1.00980466961696 0.02050155414735 10.2097131183082 1 2276.5 4087 False False 0 0 0 0 0 0 0 0.785403631924309 0.294787262784416 1.79046952832879 0.000152578577967653 3.86294767829945e-06 0.000849816992931799 0.998641765704584 0.998120122196907 0.999048533698614 1 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Leu270Met aftB_p.Leu270Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4727 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Leu276Met aftB_p.Leu276Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4651 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3824 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Leu290Val aftB_p.Leu290Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.058895521352 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Leu324Met aftB_p.Leu324Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 4698 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 3862 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Leu324Val aftB_p.Leu324Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Leu343Val aftB_p.Leu343Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Leu346Trp aftB_p.Leu346Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Leu357Val aftB_p.Leu357Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Leu380Met aftB_p.Leu380Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Leu42Ser aftB_p.Leu42Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4668 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3837 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Leu462Met aftB_p.Leu462Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Leu494Ile aftB_p.Leu494Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12104088004766 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Leu500Phe aftB_p.Leu500Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 7 9481 35698 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 3.1981371883326 0.354695326132256 279 4975 False False 0 0 2.61285174975179 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 7 6560 26498 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 3.43152889101174 0.605984763142217 320.5 4087 False False 0 0 0 0 0 0 0 0 0 2.80327602229365 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Leu588Arg aftB_p.Leu588Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4652 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3825 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Leu592Ser aftB_p.Leu592Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4703 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3866 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Leu610Phe aftB_p.Leu610Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4728 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Leu79Pro aftB_p.Leu79Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Leu86Met aftB_p.Leu86Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Leu98Phe aftB_p.Leu98Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 4 9480 35701 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999887970872426 0.999713186009257 0.999969475016731 0.2 0.00505076337946806 0.716417936118089 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.11623600185219 1 1480 4975 False False 0.941482067510548 0.0191153149568561 9.51304376083015 0 0 0.00038904660702099 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 4 6559 26501 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999849085078287 0.999613643356053 0.999958879281354 0.2 0.00505076337946806 0.716417936118089 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.780961496544 1 2276.5 4087 False False 0 0 0 0 0 0 0 1.01010062509528 0.0205075656450505 10.2127021503241 0 0 0.000562256793434776 0.999849085078287 0.999613643356053 0.999958879281354 1 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Lys481Gln aftB_p.Lys481Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Lys522Arg aftB_p.Lys522Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 30 418 9451 35287 0.00316422318320852 0.00213587538117409 0.00451406881492383 0.988292956168603 0.987122632152739 0.989382810526482 0.0669642857142857 0.0456331515846188 0.0942180679561506 NA NA NA 0 0 0.00878624382991255 NA NA NA NA 4695 4975 False True 0.267967390605485 0.17841150109281 0.388676000532312 0 0 0.000390240147376969 0.988292956168603 0.987122632152739 0.989382810526482 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 29 306 6531 26199 0.00442073170731707 0.00296257223192387 0.00634278475638182 0.988455008488964 0.987095126923734 0.989706159701276 0.0865671641791044 0.0587418131472038 0.121957944811582 NA NA NA 0 0 0.0119827892660145 NA NA NA NA 3861 4087 False True 0 1 1 0 0 0 0 0.380173291181424 0.25010961619373 0.557808750511024 0 0 0.00056466664560962 0.988455008488964 0.987095126923734 0.989706159701276 39 5) Not assoc w R New NotAwR yes 5 +Ethambutol aftB p.Lys522Asn aftB_p.Lys522Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Lys522Glu aftB_p.Lys522Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Met154Ile aftB_p.Met154Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Met199Ile aftB_p.Met199Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Met199Val aftB_p.Met199Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Met200Ile aftB_p.Met200Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4680 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3849 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Met200Thr aftB_p.Met200Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Met254Ala aftB_p.Met254Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 9 0 9 1 14 9480 35691 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999607898053494 0.999342206985133 0.999785618166341 0.0666666666666666 0.0016864302413527 0.319484566578303 0 0 0.336267116879942 0 0 0.231635761650116 0 0 1.90779724541249 0.219223371421751 251 4975 False False 0.268919529837251 0.00636280625779473 1.7679218975043 0 0 0.00038904660702099 0.999607898053494 0.999342206985133 0.999785618166341 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 1 11 6559 26494 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999584983965289 0.999257543293353 0.999792807866341 0.0833333333333333 0.00210759323186022 0.384796165150944 0 0 0.4592581264399 0 0 0.284914152918154 0 0 3.43153411862026 0.605984644606454 317 4087 False False 0 0 0 0 0 0 0 0.36721229677473 0.00853342343139249 2.52738726475638 0 0 0.000562256793434776 0.999584983965289 0.999257543293353 0.999792807866341 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Met395Ile aftB_p.Met395Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Met465Val aftB_p.Met465Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 23 5 18 5 22 9476 35683 0.000527370530534753 0.000171257241502832 0.00123027414547083 0.999383839798347 0.999067273782758 0.999613816670924 0.185185185185185 0.0630000065376768 0.380829879093994 0.217391304347826 0.0746034076488037 0.437030726236814 0.185185185185185 0.0630000065376768 0.380829879093994 1.04600511233056 0.303521417603293 2.92436788880593 1 2818.5 4975 False False 0.855822364634099 0.253122694616884 2.31691716649906 0.000527370530534753 0.000171257241502832 0.00123027414547083 0.999383839798347 0.999067273782758 0.999613816670924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 22 5 17 5 19 6555 26486 0.000762195121951219 0.000247527523788107 0.00177780526826415 0.999283154121863 0.998880781714398 0.999568358524102 0.208333333333333 0.0713186171980549 0.421512843637252 0.227272727272727 0.0782062603518925 0.453703623662122 0.208333333333333 0.0713186171980549 0.421512843637252 1.18840579710144 0.342679346758294 3.35734428716883 0.788290366233369 337 4087 False False 0 0 0 0 0 0 0 1.06331045003813 0.310194134277892 2.94574607111865 0.000762195121951219 0.000247527523788107 0.00177780526826415 0.999283154121863 0.998880781714398 0.999568358524102 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Met491Ile aftB_p.Met491Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Met496Leu aftB_p.Met496Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 3 2 9478 35703 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999943985436213 0.999797670939776 0.99999321630447 0.6 0.146632799634673 0.947255049473683 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4710 4975 False False 5.65040092846592 0.647137685918782 67.7491623796885 0 0 0.000389128685709026 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 3 1 6557 26504 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 0.999962271269571 0.999789807096406 0.999999044791703 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 3871 4087 False False 0 0 0 0 0 0 0 12.1262772609425 0.973374031902014 634.171386087929 0 0 0.000562428243381166 0.999962271269571 0.999789807096406 0.999999044791703 3 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Met77Ile aftB_p.Met77Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Met88Ile aftB_p.Met88Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 20 0 20 0 22 9481 35683 0 0 0.00038900558066021 0.999383839798347 0.999067273782758 0.999613816670924 0 0 0.154372512815574 0 0 0.168433470983085 0 0 0.154372512815574 0 0 0.762530284535533 0.0127520767150171 58 4975 False False 0 0 0.687231530422914 0 0 0.00038900558066021 0.999383839798347 0.999067273782758 0.999613816670924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 20 0 20 0 22 6560 26483 0 0 0.000562171107654053 0.999169967930579 0.998743589564863 0.99947975252246 0 0 0.154372512815574 0 0 0.168433470983085 0 0 0.154372512815574 0 0 0.817981452472442 0.0214229733109474 51 4087 False False 0 0 0 0 0 0 0 0 0 0.737212705059962 0 0 0.000562171107654053 0.999169967930579 0.998743589564863 0.99947975252246 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Met99Ile aftB_p.Met99Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.841886116991581 0 0 0.521823750104981 0 0 20.0577749283512 1 2818.5 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 157.179059039538 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Phe171Leu aftB_p.Phe171Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Phe189Leu aftB_p.Phe189Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Phe227Val aftB_p.Phe227Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Phe344Val aftB_p.Phe344Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4688 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3856 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Phe587Leu aftB_p.Phe587Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4714 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3875 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Phe597Cys aftB_p.Phe597Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Phe597Leu aftB_p.Phe597Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Pro129Leu aftB_p.Pro129Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Pro129Ser aftB_p.Pro129Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Pro130Ser aftB_p.Pro130Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Pro161Ser aftB_p.Pro161Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Pro263Leu aftB_p.Pro263Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Pro269Thr aftB_p.Pro269Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Pro296Leu aftB_p.Pro296Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Pro296Thr aftB_p.Pro296Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Pro309Arg aftB_p.Pro309Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4744 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3897 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Pro342Leu aftB_p.Pro342Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Pro342Ser aftB_p.Pro342Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Pro349Arg aftB_p.Pro349Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Pro358Leu aftB_p.Pro358Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 9478 35705 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 1 0.999896689850119 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4731 4975 False False Inf 1.55639137151076 Inf 0 0 0.000389128685709026 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3887 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 2 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Pro393Ser aftB_p.Pro393Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4681 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3850 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Pro423Leu aftB_p.Pro423Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4742 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Pro423Ser aftB_p.Pro423Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4670 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3839 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Pro446Leu aftB_p.Pro446Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Pro468Arg aftB_p.Pro468Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Pro468Ser aftB_p.Pro468Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 10 5 9471 35700 0.0010547410610695 0.00050590153672643 0.00193884812290577 0.999859963590533 0.999673232250017 0.999954529045718 0.666666666666666 0.383803732541154 0.881758896633119 NA NA NA 0 0 0.521823750104981 NA NA NA NA 4722 4975 False False 7.53880266075388 2.34688833388164 28.0942294435112 0 0 0.000389416234052975 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 10 5 6550 26500 0.00152439024390243 0.000731238785140689 0.00280161526425175 0.999811356347858 0.999559824020536 0.9999387451734 0.666666666666666 0.383803732541154 0.881758896633119 NA NA NA 0 0 0.521823750104981 NA NA NA NA 3881 4087 False False 0 0 0 0 0 0 0 8.09160305343511 2.51868248404431 30.1791161062776 0 0 0.000563029142491623 0.999811356347858 0.999559824020536 0.9999387451734 5 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Pro478Ser aftB_p.Pro478Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.19822685561766 0.354697857676227 290 4975 False False 0 0 3.19822685561766 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Pro513Ala aftB_p.Pro513Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Pro513Leu aftB_p.Pro513Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Pro513Ser aftB_p.Pro513Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 5.70499352101301 0.585896604883905 379.5 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 6.12080991862283 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Pro534Gln aftB_p.Pro534Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4657 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3830 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Pro534Ser aftB_p.Pro534Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4715 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3876 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Pro548Gln aftB_p.Pro548Gln 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4711 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3872 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Pro548Leu aftB_p.Pro548Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Pro548Ser aftB_p.Pro548Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Pro551Leu aftB_p.Pro551Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Pro569Leu aftB_p.Pro569Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4699 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Pro569Ser aftB_p.Pro569Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Pro618Ser aftB_p.Pro618Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Pro621Arg aftB_p.Pro621Arg 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 10 9477 35695 0.000421896424427802 0.000114964157806894 0.00107986688593449 0.999719927181067 0.999484996631079 0.999865686288203 0.285714285714285 0.0838893183071275 0.581035257183661 NA NA NA 0 0 0.30849710781876 NA NA NA NA 4676 4975 False False 1.50659491400232 0.3448246436219 5.2248765690981 0 0 0.000389169738041761 0.999719927181067 0.999484996631079 0.999865686288203 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 10 6556 26495 0.000609756097560975 0.000166162208307701 0.00156047520083291 0.999622712695717 0.999306265033238 0.999819061720012 0.285714285714285 0.0838893183071275 0.581035257183661 NA NA NA 0 0 0.30849710781876 NA NA NA NA 3844 4087 False False 0 0 0 0 0 0 0 1.61653447223917 0.369946863340775 5.60642581211926 0 0 0.000562514007570737 0.999622712695717 0.999306265033238 0.999819061720012 2 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Pro621Ser aftB_p.Pro621Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 8 9480 35697 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999775941744853 0.999558563909973 0.999903262744512 0.111111111111111 0.00280913674659921 0.482496514917337 NA NA NA 0 0 0.369416647552819 NA NA NA NA 4734 4975 False False 0.47068829113924 0.010610026508271 3.51159115085171 0 0 0.00038904660702099 0.999775941744853 0.999558563909973 0.999903262744512 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 8 6559 26497 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999698170156574 0.999405361976814 0.999869682578628 0.111111111111111 0.00280913674659921 0.482496514917337 NA NA NA 0 0 0.369416647552819 NA NA NA NA 3889 4087 False False 0 0 0 0 0 0 0 0.504974081414849 0.0113820510464553 3.76768363928727 0 0 0.000562256793434776 0.999698170156574 0.999405361976814 0.999869682578628 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Pro623Leu aftB_p.Pro623Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Pro624Leu aftB_p.Pro624Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 5.70499352101301 0.585896604883905 379.5 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 6.12080991862283 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Pro76Gln aftB_p.Pro76Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ser137Ala aftB_p.Ser137Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 4732 4975 False False 0 0 3.19822685561766 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3888 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ser182Asn aftB_p.Ser182Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4743 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3895 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ser273Leu aftB_p.Ser273Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ser288Leu aftB_p.Ser288Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4658 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3831 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ser318Gly aftB_p.Ser318Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ser364Ala aftB_p.Ser364Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4716 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ser364Trp aftB_p.Ser364Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ser405Leu aftB_p.Ser405Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ser405Trp aftB_p.Ser405Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ser469Ala aftB_p.Ser469Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4659 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3832 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ser469Leu aftB_p.Ser469Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 7 58 9474 35647 0.000738318742748655 0.00029689231210758 0.00152062336565454 0.998375577650189 0.997900556820432 0.998766284052575 0.107692307692307 0.0444086569208471 0.209381599257904 0 0 0.409616397225003 0 0 0.0616210089039198 0 0 2.6110472617035 0.357650229267454 323 4975 False False 0.454108522053096 0.174793668254516 0.996917048527903 0 0 0.000389292947027732 0.998375577650189 0.997900556820432 0.998766284052575 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 7 49 6553 26456 0.0010670731707317 0.000429122972600259 0.00219733487653492 0.998151292209017 0.997556638020031 0.998632012465253 0.125 0.0517645048792003 0.240732579652068 0 0 0.409616397225003 0 0 0.0725192636642774 0 0 2.80182365830717 0.357893115453357 203 4087 False False 0 0 0 0 0 0 0 0.576747836323603 0.220323034734124 1.28083276390575 0 0 0.000562771457148547 0.998151292209017 0.997556638020031 0.998632012465253 14 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ser577Cys aftB_p.Ser577Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ser589Phe aftB_p.Ser589Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ser594Phe aftB_p.Ser594Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ser91Ala aftB_p.Ser91Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 17 0 17 1 25 9480 35680 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999299817952667 0.998966565499085 0.999546829455204 0.0384615384615384 0.00097328789333503 0.196369646762539 0 0 0.195064322969093 0 0 0.137185171530712 0 0 0.912316179277131 0.0328403354320547 80 4975 False False 0.150548523206751 0.00367011474722141 0.919963110620938 0 0 0.00038904660702099 0.999299817952667 0.998966565499085 0.999546829455204 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 17 0 17 1 25 6559 26480 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999056781739294 0.998607936501749 0.999389508781733 0.0384615384615384 0.00097328789333503 0.196369646762539 0 0 0.195064322969093 0 0 0.137185171530712 0 0 0.978681855922755 0.0336598706433393 58 4087 False False 0 0 0 0 0 0 0 0.161488031712151 0.00393629803028908 0.986905035565718 0 0 0.000562256793434776 0.999056781739294 0.998607936501749 0.999389508781733 1 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ser9Trp aftB_p.Ser9Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ter628Argext*? aftB_p.Ter628Argext*? 2 stop_lost (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ter628ext*? aftB_p.Ter628ext*? 2 stop_lost (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Ter628Serext*? aftB_p.Ter628Serext*? 2 stop_lost (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.10982832991351 0.590980565810755 492 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.40943166615857 0.590385352956204 278 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Thr102Ala aftB_p.Thr102Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4654 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3827 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Thr102Ile aftB_p.Thr102Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Thr11Met aftB_p.Thr11Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Thr282Met aftB_p.Thr282Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 49 1 48 2 53 9479 35652 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.998515614059655 0.998058830612361 0.998887901464271 0.0363636363636363 0.00443454731859069 0.12526425709715 0.0204081632653061 0.000516556497593286 0.108541763968406 0.0185185185185185 0.00046873840381796 0.0989151595078512 0.0783574216689524 0.00194765339677302 0.458092517100464 0.000282920671666422 24 4975 False False 0.141930424155083 0.0167426096954027 0.538809264678397 0.00010548523206751 2.670651284468e-06 0.000587584402906152 0.998515614059655 0.998058830612361 0.998887901464271 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 47 1 46 2 49 6558 26456 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.998151292209017 0.997556638020031 0.998632012465253 0.0392156862745098 0.00478499269470729 0.134586491129664 0.0212765957446808 0.000538531705342315 0.1129377171464 0.02 0.000506227983040829 0.106469545711499 0.0876990598936579 0.00217731305422007 0.513834066196139 0.000702262094119831 26 4087 False False 0 0 0 0 0 0 0 0.164659459392174 0.0193987440959325 0.627685814454115 0.000152462265589266 3.86000291520843e-06 0.000849169393567967 0.998151292209017 0.997556638020031 0.998632012465253 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Thr403Ile aftB_p.Thr403Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Thr440Ala aftB_p.Thr440Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Thr445Ile aftB_p.Thr445Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4704 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Thr583Asn aftB_p.Thr583Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 9 0 9 0 12 9481 35693 0 0 0.00038900558066021 0.99966391261728 0.999412996653316 0.999826327071809 0 0 0.264648469397051 0 0 0.336267116879942 0 0 0.264648469397051 0 0 1.90770287770578 0.21922392121523 254.5 4975 False False 0 0 1.35519147325258 0 0 0.00038900558066021 0.99966391261728 0.999412996653316 0.999826327071809 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 0 12 6560 26493 0 0 0.000562171107654053 0.999547255234861 0.999209279704825 0.999766038988972 0 0 0.264648469397051 0 0 0.336267116879942 0 0 0.264648469397051 0 0 2.04667921725802 0.220127507052216 159 4087 False False 0 0 0 0 0 0 0 0 0 1.45386850159099 0 0 0.000562171107654053 0.999547255234861 0.999209279704825 0.999766038988972 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Trp19Cys aftB_p.Trp19Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 5.70499352101301 0.585896604883905 379.5 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 21.5173342675905 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Trp22Arg aftB_p.Trp22Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 8 9481 35697 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 4662 4975 False False 0 0 2.20624116275339 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3835 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Trp379Cys aftB_p.Trp379Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Trp546Cys aftB_p.Trp546Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Trp546Gly aftB_p.Trp546Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 2 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Trp63Tyr aftB_p.Trp63Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4733 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Tyr106Cys aftB_p.Tyr106Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 9477 35705 0.000421896424427802 0.000114964157806894 0.00107986688593449 1 0.999896689850119 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 4682 4975 False False Inf 2.4863933079676 Inf 0 0 0.000389169738041761 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 6556 26505 0.000609756097560975 0.000166162208307701 0.00156047520083291 1 0.999860832946126 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3851 4087 False False 0 0 0 0 0 0 0 Inf 2.66797681781562 Inf 0 0 0.000562514007570737 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Tyr298Asp aftB_p.Tyr298Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Tyr298Cys aftB_p.Tyr298Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Tyr404Phe aftB_p.Tyr404Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Tyr81His aftB_p.Tyr81His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Val124Leu aftB_p.Val124Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Val144Met aftB_p.Val144Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4735 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Val15Met aftB_p.Val15Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Val178Ile aftB_p.Val178Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Val185Ala aftB_p.Val185Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0615661524565 1 2818.5 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.5214194708504 1 2276.5 4087 False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 0 0 0.000562256793434776 0.999924542539143 0.999727448570663 0.999990861620785 4 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Val211Gly aftB_p.Val211Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4705 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Val214Gly aftB_p.Val214Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Val268Leu aftB_p.Val268Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Val271Ala aftB_p.Val271Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4671 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3840 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Val274Ala aftB_p.Val274Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 18 0 18 2 20 9479 35685 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999439854362134 0.999135032404509 0.999657815983264 0.0909090909090909 0.0112055860241509 0.291612741553933 0 0 0.185301968137852 0 0 0.168433470983085 0 0 0.856463774374193 0.0203557973935376 66 4975 False False 0.376463762000211 0.0426582813644047 1.5502302403742 0 0 0.000389087642036349 0.999439854362134 0.999135032404509 0.999657815983264 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 16 0 16 2 18 6558 26487 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999320882852292 0.998926913664084 0.999597464048431 0.1 0.0123485271702948 0.316982714019082 0 0 0.205907214207822 0 0 0.185301968137852 0 0 1.0476244911349 0.0545749494823402 74.5 4087 False False 0 0 0 0 0 0 0 0.448764867337602 0.0504895302137191 1.87519985544009 0 0 0.00056234250533983 0.999320882852292 0.998926913664084 0.999597464048431 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Val293Met aftB_p.Val293Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 126 3 123 92 152 9389 35553 0.00970361776183946 0.00782945204478436 0.0118875316574523 0.995742893152219 0.995011598551876 0.996391634978214 0.377049180327868 0.316017254476922 0.441107687405029 0.0238095238095238 0.00493727032011603 0.0680048643419406 0.0193548387096774 0.00400935762485796 0.0555192349276983 0.0923576889406129 0.0187993411467341 0.276411741787506 1.71762673321475e-09 12 4975 True False 2.29192896502626 1.74759258058678 2.99180369884963 0.000319420783645655 6.5877089469963e-05 0.000933196508162886 0.995742893152219 0.995011598551876 0.996391634978214 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 84 2 82 48 102 6512 26403 0.0073170731707317 0.00539981756929644 0.00968980083769399 0.996151669496321 0.995330313628136 0.996861089605236 0.32 0.246269515712425 0.401005785663308 0.0238095238095238 0.00289656297053299 0.0833744665669055 0.0192307692307692 0.00233747960860998 0.0677448948917636 0.0988906034637742 0.0117600999669619 0.369000594461756 3.29253212818136e-06 16 4087 True False 0 0 0 0 0 0 0 1.9080069374187 1.32320691750741 2.71762682562974 0.000307031010132023 3.71850427582858e-05 0.00110865687650932 0.996151669496321 0.995330313628136 0.996861089605236 143 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Val316Ala aftB_p.Val316Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4663 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3836 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Val320Met aftB_p.Val320Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4684 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Val338Met aftB_p.Val338Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Val350Ala aftB_p.Val350Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4717 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Val352Ala aftB_p.Val352Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Val352Gly aftB_p.Val352Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Val372Gly aftB_p.Val372Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 1 9479 35704 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999971992718106 0.999843963402622 0.999999290917266 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 4724 4975 False False 7.53328410169849 0.392120325718966 443.147628387906 0 0 0.000389087642036349 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3883 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Val408Ala aftB_p.Val408Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Val48Ala aftB_p.Val48Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Val504Met aftB_p.Val504Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Val544Met aftB_p.Val544Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 11 0 11 0 12 9481 35693 0 0 0.00038900558066021 0.99966391261728 0.999412996653316 0.999826327071809 0 0 0.264648469397051 0 0 0.284914152918154 0 0 0.264648469397051 0 0 1.50030489649552 0.135454869906327 152.5 4975 False False 0 0 1.35519147325258 0 0 0.00038900558066021 0.99966391261728 0.999412996653316 0.999826327071809 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Val55Ile aftB_p.Val55Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.096562813829025 Inf 0.209821626167397 198.5 4975 False False Inf 0.096562813829025 Inf 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.103599830448027 Inf 0.198397096627854 142 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Val574Leu aftB_p.Val574Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Val574Met aftB_p.Val574Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Val611Leu aftB_p.Val611Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Val611Phe aftB_p.Val611Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Val617Ile aftB_p.Val617Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Val69Met aftB_p.Val69Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3845 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol aftB p.Val89Leu aftB_p.Val89Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4740 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3893 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA c.1009C>T embA_c.1009C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.76624472573839 0.0479745002090283 294.932792118969 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1014C>T embA_c.1014C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1023T>C embA_c.1023T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1030C>T embA_c.1030C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1039C>T embA_c.1039C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1041G>C embA_c.1041G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1047G>A embA_c.1047G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1053G>A embA_c.1053G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.19822685561766 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1056C>T embA_c.1056C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.707313928675496 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1071C>T embA_c.1071C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1080T>G embA_c.1080T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1089C>T embA_c.1089C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.108G>A embA_c.108G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 5 9480 35700 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999859963590533 0.999673232250017 0.999954529045718 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.753164556962025 0.0159260191955521 6.73154939272228 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 3 6559 26502 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999886813808715 0.999669257903365 0.999976657677988 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.34685165421558 0.025651688752077 16.7753654027497 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.108G>C embA_c.108G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1092T>C embA_c.1092T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1122G>A embA_c.1122G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1134C>G embA_c.1134C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1146G>A embA_c.1146G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.114A>G embA_c.114A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1022 626 8459 35079 0.107794536441303 0.101620573725853 0.114210595288455 0.982467441534799 0.981052176092167 0.983803429296082 0.620145631067961 0.596212146057269 0.643650279308868 NA NA NA NA NA NA NA NA NA NA NA NA False False 6.77025056398708 6.10539471299731 7.51065757643435 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 966 353 5594 26152 0.147256097560975 0.138762920236323 0.156064124496602 0.986681758158838 0.98522819715036 0.988027122092339 0.732373009855951 0.707601235867149 0.75610484028737 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 12.7933672358384 11.2725749719487 14.5485929189891 NA NA NA NA NA NA 252 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1159C>T embA_c.1159C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1168C>T embA_c.1168C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1170G>A embA_c.1170G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1176G>A embA_c.1176G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 3 9480 35702 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99991597815432 0.999754472342108 0.99998267234027 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.25534458509142 0.0239099774609589 15.6346568618898 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1185G>A embA_c.1185G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1188G>C embA_c.1188G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 15 918 9466 34787 0.00158211159160426 0.000885757734327454 0.00260811203671776 0.974289315221957 0.972594557806269 0.975906316063872 0.0160771704180064 0.00902546593153836 0.0263783954493447 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.0600480702175933 0.0334292215469647 0.0996328567705303 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 11 872 6549 25633 0.00167682926829268 0.000837354988859942 0.00299832542833478 0.967100547066591 0.964882419794911 0.96921548306806 0.0124575311438278 0.00623471113599077 0.0221804252552284 NA NA NA NA NA NA NA NA NA NA NA NA False True 1 1 1 0 0 0 1 0.049374265417649 0.0245373756392859 0.0888457986101733 NA NA NA NA NA NA 46 5) Not assoc w R Now listed Silent mutation no 0 +Ethambutol embA c.1194G>A embA_c.1194G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1197G>C embA_c.1197G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.-11C>A embA_c.-11C>A 1 upstream_gene_variant 4243222 1 26 11 15 128 29 9353 35676 0.0135006855816896 0.0112753551712387 0.016031828942327 0.999187788825094 0.998833735901384 0.999455984066987 0.815286624203821 0.74561531379042 0.872666797600357 0.423076923076923 0.233521983127443 0.630819619076033 0.275 0.146008991963865 0.438882907179048 2.79722014326953 1.16167109333671 6.51920599564484 0.012935498679338 61 4975 False False 16.8359331507132 11.167824571408 26.1459665130402 0.00117471166168304 0.000586553075970944 0.00210090928463683 0.999187788825094 0.998833735901384 0.999455984066987 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 18 10 8 57 15 6503 26490 0.0086890243902439 0.00658743583955476 0.0112431627917225 0.999434069043576 0.999066754461952 0.999683219243554 0.791666666666666 0.679770488870628 0.878448797092191 0.555555555555555 0.307571658998756 0.7846984926127 0.4 0.211254806465142 0.61334650374316 5.09188067045978 1.80849022164271 14.8552512632204 0.000811088929289613 27 4087 False False 0 0 0 0 0 0 0 15.4793172381977 8.63947569364582 29.4446013742467 0.00153539075694764 0.000736517355161662 0.0028218196340349 0.999434069043576 0.999066754461952 0.999683219243554 114 3) Uncertain significance No change no 1 +Ethambutol embA c.-11C>T embA_c.-11C>T 1 upstream_gene_variant 4243222 1 2 0 2 38 12 9443 35693 0.00400801603206412 0.00283782488513525 0.00549720571138138 0.99966391261728 0.999412996653316 0.999826327071809 0.76 0.618309251895961 0.869390083802542 0 0 0.841886116991581 0 0 0.264648469397051 0 0 20.134338596765 1 2818.5 4975 False False 11.9694835680751 6.11989538151073 25.1711607065022 0 0 0.000390570689729421 0.99966391261728 0.999412996653316 0.999826327071809 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 32 7 6528 26498 0.0048780487804878 0.00333890307856758 0.0068794310839757 0.999735898887002 0.999455926960675 0.999893811273379 0.82051282051282 0.664650438873069 0.924649522683347 0 0 0.841886116991581 0 0 0.409616397225003 0 0 21.619367668755 1 2276.5 4087 False False 0 0 0 0 0 0 0 18.5560224089635 8.03965786459254 49.8768253004541 0 0 0.000564926069836696 0.999735898887002 0.999455926960675 0.999893811273379 3 3) Uncertain significance No change no 1 +Ethambutol embA c.1203G>A embA_c.1203G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1215G>C embA_c.1215G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1224C>G embA_c.1224C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 10 9481 35695 0 0 0.00038900558066021 0.999719927181067 0.999484996631079 0.999865686288203 0 0 0.30849710781876 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.67996531074212 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 10 6560 26495 0 0 0.000562171107654053 0.999622712695717 0.999306265033238 0.999819061720012 0 0 0.30849710781876 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.80248078294835 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1227G>A embA_c.1227G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1236C>A embA_c.1236C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 0 NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1236C>T embA_c.1236C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.123G>A embA_c.123G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1269G>A embA_c.1269G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1269G>C embA_c.1269G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1272G>A embA_c.1272G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 3 3 9478 35702 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.99991597815432 0.999754472342108 0.99998267234027 0.5 0.118117248757025 0.881882751242974 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.76682844481958 0.504418797674528 28.1425087484132 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 2 3 6558 26502 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999886813808715 0.999669257903365 0.999976657677988 0.4 0.0527449505263169 0.853367200365326 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.69411405916437 0.224966079471659 23.5225659748306 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1275G>T embA_c.1275G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1278G>A embA_c.1278G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 18 9479 35687 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.99949586892592 0.999203372130377 0.999701193476901 0.1 0.0123485271702948 0.316982714019082 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.418316512524762 0.0470668415896743 1.74779566238141 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 2 15 6558 26490 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999434069043576 0.999066754461952 0.999683219243554 0.117647058823529 0.0145793168403025 0.36440916210125 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.538578835010673 0.0597520054628389 2.31674361785185 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.-12C>A embA_c.-12C>A 1 upstream_gene_variant 4243221 0 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3282 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2692 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA c.-12C>T embA_c.-12C>T 1 upstream_gene_variant 4243221 1 97 30 67 635 173 8846 35532 0.0669760573779137 0.0620250998482723 0.0721950122277113 0.99515474023246 0.994378679841915 0.995848480173656 0.78589108910891 0.755970257691932 0.813708816731205 0.309278350515463 0.219339456798009 0.411231487472628 0.147783251231527 0.101983080257324 0.204200553883771 1.79853614585899 1.12780581708108 2.80744310049118 0.0103937576716236 55 4975 False False 14.7434913922101 12.4218553504924 17.5679018661768 0.00337990085624155 0.0022815314649943 0.00482153115773969 0.99515474023246 0.994378679841915 0.995848480173656 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 77 24 53 446 123 6114 26382 0.0679878048780487 0.0620131998015907 0.0743498224642744 0.995359366157328 0.994465550035418 0.996141738738791 0.783831282952548 0.747699594434094 0.816985028748009 0.311688311688311 0.210946842255908 0.427427526693383 0.163265306122448 0.107496991448838 0.233116291060567 1.95396892995352 1.15259550121808 3.22385845233566 0.00832969417318214 36 4087 False False 0 0 0 0 0 0 0 15.6463135386996 12.7583195099148 19.2881962823601 0.00391006842619745 0.00250681248350158 0.00581232060882722 0.995359366157328 0.994465550035418 0.996141738738791 150 Assoc w R 3) Uncertain significance DOWN from AwR to Uncertain yes 2 +Ethambutol embA c.1305T>C embA_c.1305T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1308G>A embA_c.1308G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1311C>T embA_c.1311C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.88306962025316 0.0319145727646777 36.1783621216076 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1314C>A embA_c.1314C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1320C>G embA_c.1320C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1332G>C embA_c.1332G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1338C>G embA_c.1338C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1339C>A embA_c.1339C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1353A>C embA_c.1353A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1353A>G embA_c.1353A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1359G>C embA_c.1359G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1366C>T embA_c.1366C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1368G>A embA_c.1368G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1383G>A embA_c.1383G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1389G>A embA_c.1389G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1407G>C embA_c.1407G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1416G>A embA_c.1416G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1422G>A embA_c.1422G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1431C>G embA_c.1431C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1434G>A embA_c.1434G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.76624472573839 0.0479745002090283 294.932792118969 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1446G>A embA_c.1446G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.76624472573839 0.0479745002090283 294.932792118969 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1449A>G embA_c.1449A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1458G>A embA_c.1458G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1461C>T embA_c.1461C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1467C>T embA_c.1467C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1470C>T embA_c.1470C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1473G>A embA_c.1473G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1497C>T embA_c.1497C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.19822685561766 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1498C>T embA_c.1498C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.-15_-14insTACCATCGAG embA_c.-15_-14insTACCATCGAG 1 upstream_gene_variant 4243218 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3319 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2723 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 1 3) Uncertain significance No change no 1 +Ethambutol embA c.1500G>A embA_c.1500G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.10982832991351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1500G>C embA_c.1500G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 11 9481 35694 0 0 0.00038900558066021 0.999691919899173 0.999448826618347 0.999846197812 0 0 0.284914152918154 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.50034693324555 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 11 6560 26494 0 0 0.000562171107654053 0.999584983965289 0.999257543293353 0.999792807866341 0 0 0.284914152918154 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.60965686204705 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1503C>T embA_c.1503C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1509C>T embA_c.1509C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 13 0 9468 35705 0.00137116337939035 0.000730282374626527 0.00234358976784705 1 0.999896689850119 1 1 0.752947361999529 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 11.4899095920826 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 4 0 6556 26505 0.000609756097560975 0.000166162208307701 0.00156047520083291 1 0.999860832946126 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 2.66797681781562 Inf NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1512C>T embA_c.1512C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 3 9480 35702 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99991597815432 0.999754472342108 0.99998267234027 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.25534458509142 0.0239099774609589 15.6346568618898 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1515T>C embA_c.1515T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1518C>T embA_c.1518C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1521G>A embA_c.1521G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1524G>A embA_c.1524G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1530C>T embA_c.1530C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1536G>A embA_c.1536G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.153C>T embA_c.153C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1557C>T embA_c.1557C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.156C>T embA_c.156C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1584G>A embA_c.1584G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1593G>C embA_c.1593G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.-15C>G embA_c.-15C>G 1 upstream_gene_variant 4243218 1 5 2 3 34 14 9447 35691 0.00358611960763632 0.00248473185647407 0.00500767053673668 0.999607898053494 0.999342206985133 0.999785618166341 0.708333333333333 0.559365220086309 0.830469201371971 0.4 0.0527449505263169 0.853367200365326 0.125 0.0155136038154138 0.383476236849263 2.51868317984545 0.210330233111778 21.9897289434706 0.281891870117023 261 4975 False False 9.17520301229415 4.79339910863884 18.5131748581736 0.000211662609799978 2.56343519562118e-05 0.000764386765841687 0.999607898053494 0.999342206985133 0.999785618166341 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 29 9 6531 26496 0.00442073170731707 0.00296257223192387 0.00634278475638182 0.999660441426146 0.999355510362951 0.999844720818052 0.763157894736842 0.597587639428509 0.885558295177469 0.333333333333333 0.00840375865961264 0.905700675949754 0.1 0.00252857854446178 0.445016117028195 2.02847955902618 0.0343773920984984 38.9362371152503 0.483697958862406 235 4087 False False 0 0 0 0 0 0 0 13.0724238248354 6.01940049947981 31.4042912014996 0.000153092467850581 3.87595819333673e-06 0.000852678204149666 0.999660441426146 0.999355510362951 0.999844720818052 23 3) Uncertain significance No change no 1 +Ethambutol embA c.1602G>T embA_c.1602G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1606C>T embA_c.1606C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1608G>A embA_c.1608G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 16 9481 35689 0 0 0.00038900558066021 0.999551883489707 0.999272388596077 0.99974384169233 0 0 0.205907214207822 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.976295497466411 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 14 6560 26491 0 0 0.000562171107654053 0.999471797774004 0.999113925067086 0.999711197799087 0 0 0.231635761650116 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.21779664057642 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1617C>T embA_c.1617C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1632G>A embA_c.1632G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1635C>A embA_c.1635C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 6 0 9475 35705 0.000632844636641704 0.000232277107744303 0.00137692358870305 1 0.999896689850119 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 4.43555551883467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 6 0 6554 26505 0.000914634146341463 0.000335726224038477 0.00198970246660848 1 0.999860832946126 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 4.75965536954277 Inf NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1644G>A embA_c.1644G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1659C>T embA_c.1659C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 4 1 9477 35704 0.000421896424427802 0.000114964157806894 0.00107986688593449 0.999971992718106 0.999843963402622 0.999999290917266 0.8 0.28358206388191 0.994949236620532 NA NA NA NA NA NA NA NA NA NA NA NA False False 15.0697478104885 1.49093500364622 739.038051857485 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 4 1 6556 26504 0.000609756097560975 0.000166162208307701 0.00156047520083291 0.999962271269571 0.999789807096406 0.999999044791703 0.8 0.28358206388191 0.994949236620532 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 16.1708358755338 1.59970034177407 792.771744020614 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.165C>T embA_c.165C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1665T>C embA_c.1665T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.10982832991351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.40943166615857 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1692G>C embA_c.1692G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1695C>T embA_c.1695C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.-16C>A embA_c.-16C>A 1 upstream_gene_variant 4243217 1 29 16 13 104 35 9377 35670 0.0109693070351228 0.00897126786770282 0.0132756922060858 0.999019745133734 0.998636963904226 0.999317124544511 0.74820143884892 0.667596736058862 0.817923051634394 0.551724137931034 0.356938710803913 0.735544696293295 0.313725490196078 0.19110397147758 0.458872902620608 4.6818319784087 2.11058739406889 10.5839487308702 5.07881178208293e-05 21 4975 True False 11.3032800621581 7.63331427709507 17.10173722983 0.00170339614606621 0.00097394170703559 0.00276473857901191 0.999019745133734 0.998636963904226 0.999317124544511 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 21 12 9 77 26 6483 26479 0.0117378048780487 0.00927408815941915 0.0146486922024421 0.999019053008866 0.998563013375042 0.999359115925842 0.74757281553398 0.652405797627095 0.82800980353863 0.571428571428571 0.340206309280274 0.781803143114869 0.31578947368421 0.175025338901126 0.486527054406021 5.44583269062676 2.10482321092448 14.6465895937718 0.000165233642156341 22 4087 True False 0 0 0 0 0 0 0 12.0960322262959 7.65732846571204 19.6706723687303 0.00184757505773672 0.000955021972350346 0.0032251153910645 0.999019053008866 0.998563013375042 0.999359115925842 46 3) Uncertain significance No change no 1 +Ethambutol embA c.-16C>G embA_c.-16C>G 1 upstream_gene_variant 4243217 1 45 11 34 139 48 9342 35657 0.0146609007488661 0.0123388352666374 0.0172877043278149 0.998655650469122 0.99821797803272 0.999008621572115 0.74331550802139 0.674471288973561 0.804274132828694 0.244444444444444 0.128822814603507 0.395370928759826 0.186440677966101 0.0969194651172766 0.309148653421927 1.23486279547143 0.564168102896493 2.49686941544221 0.580397833577424 359 4975 False False 11.052957521587 7.90038143825812 15.7041994013718 0.00117609323211803 0.000587243083466602 0.0021033790025771 0.998655650469122 0.99821797803272 0.999008621572115 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 2 7 98 11 6462 26494 0.0149390243902439 0.0121444194641604 0.0181760718321121 0.999584983965289 0.999257543293353 0.999792807866341 0.899082568807339 0.826602667872194 0.948536277947909 0.222222222222222 0.0281449734778982 0.600093573716312 0.153846153846153 0.0192066719825284 0.454471055676557 1.17141972852279 0.118684534527997 6.15449301473525 0.692121296034311 330 4087 False False 0 0 0 0 0 0 0 36.5269969893925 19.5373556380043 75.6470963265226 0.000309405940594059 3.74726914492224e-05 0.00111722903637499 0.999584983965289 0.999257543293353 0.999792807866341 66 3) Uncertain significance No change no 1 +Ethambutol embA c.-16C>T embA_c.-16C>T 1 upstream_gene_variant 4243217 1 100 22 78 300 122 9181 35583 0.0316422318320852 0.0282105205244644 0.0353654852874972 0.996583111609018 0.995921583530383 0.997161697626578 0.710900473933649 0.66508681739236 0.753727999211276 0.22 0.143303576749814 0.313919653786317 0.152777777777777 0.0982903403910005 0.22212201517161 1.09315224585892 0.647950372074411 1.77451478823486 0.710130804332092 534 4975 False False 9.53046294824843 7.68429432156127 11.877607550494 0.00239052482886015 0.00149871677144834 0.00361705936612471 0.996583111609018 0.995921583530383 0.997161697626578 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 64 17 47 197 80 6363 26425 0.030030487804878 0.0260342380018696 0.0344513976126957 0.996981701565742 0.996244853601635 0.997605973637245 0.711191335740072 0.653947881423883 0.763851493601307 0.265625 0.16297605146851 0.39087612915341 0.175257731958762 0.105538643874783 0.265709093050831 1.50211829693607 0.808058716288864 2.66717282228475 0.154583680144848 116 4087 False False 0 0 0 0 0 0 0 10.2265539053905 7.83408785444526 13.4477494589351 0.00266457680250783 0.00155295659896774 0.00426282872150362 0.996981701565742 0.996244853601635 0.997605973637245 191 3) Uncertain significance No change no 1 +Ethambutol embA c.-16delC embA_c.-16delC 1 upstream_gene_variant 4243216 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3288 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2698 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embA c.1704C>T embA_c.1704C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1716G>A embA_c.1716G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1737G>A embA_c.1737G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1738C>T embA_c.1738C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 9 9479 35696 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.99974793446296 0.999521555266748 0.999884733314884 0.181818181818181 0.0228311982999596 0.517755852360172 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.836844017770275 0.0879719531671099 4.04425008799206 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 9 6559 26496 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999660441426146 0.999355510362951 0.999844720818052 0.1 0.00252857854446178 0.445016117028195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.448848909894801 0.0102423495192947 3.24032619577018 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1740G>A embA_c.1740G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1746G>T embA_c.1746G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 11 9481 35694 0 0 0.00038900558066021 0.999691919899173 0.999448826618347 0.999846197812 0 0 0.284914152918154 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.50034693324555 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 11 6560 26494 0 0 0.000562171107654053 0.999584983965289 0.999257543293353 0.999792807866341 0 0 0.284914152918154 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.60965686204705 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1758G>C embA_c.1758G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.10982832991351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1764C>A embA_c.1764C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1767G>A embA_c.1767G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1776T>C embA_c.1776T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1789C>T embA_c.1789C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1791A>G embA_c.1791A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.-17G>A embA_c.-17G>A 1 upstream_gene_variant 4243216 1 13 1 12 11 20 9470 35685 0.00116021516717645 0.00057931301275248 0.00207499495108562 0.999439854362134 0.999135032404509 0.999657815983264 0.354838709677419 0.192267434425977 0.546304398049361 0.0769230769230769 0.00194562849734675 0.360297435267877 0.0476190476190476 0.00120488344836351 0.238159909936821 0.314017951425554 0.00734858681079117 2.12289378278044 0.325369700721365 265 4975 False False 2.07251847940865 0.89661316565273 4.5389942291261 0.000105585471439129 2.67318911885021e-06 0.000588142631535891 0.999439854362134 0.999135032404509 0.999657815983264 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 1 7 8 8 6552 26497 0.00121951219512195 0.000526641184096925 0.00240150352406598 0.999698170156574 0.999405361976814 0.999869682578628 0.5 0.246510111490575 0.753489888509424 0.125 0.0031597235312519 0.526509670875206 0.111111111111111 0.00280913674659921 0.482496514917337 0.577729809872667 0.0128203361218789 4.49824479921353 1 1103 4087 False False 0 0 0 0 0 0 0 4.04410866910866 1.32244158492889 12.3660615182455 0.000152601861742713 3.86353717016821e-06 0.000849946631353037 0.999698170156574 0.999405361976814 0.999869682578628 18 3) Uncertain significance No change no 1 +Ethambutol embA c.180C>T embA_c.180C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.19822685561766 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1812G>A embA_c.1812G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1812G>T embA_c.1812G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1815G>C embA_c.1815G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.183T>G embA_c.183T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1840C>T embA_c.1840C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1842G>C embA_c.1842G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.184C>T embA_c.184C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.88306962025316 0.0319145727646777 36.1783621216076 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1851A>G embA_c.1851A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 4 9 9477 35696 0.000421896424427802 0.000114964157806894 0.00107986688593449 0.99974793446296 0.999521555266748 0.999884733314884 0.307692307692307 0.0909203945720966 0.614261661750705 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.6740412460577 0.376623511887483 5.99961262782162 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 4 9 6556 26496 0.000609756097560975 0.000166162208307701 0.00156047520083291 0.999660441426146 0.999355510362951 0.999844720818052 0.307692307692307 0.0909203945720966 0.614261661750705 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.79621720561317 0.40406920005862 6.43859160109992 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1860C>T embA_c.1860C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1869G>A embA_c.1869G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.186G>T embA_c.186G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1890C>T embA_c.1890C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1893G>A embA_c.1893G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1899G>A embA_c.1899G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 18 57 9463 35648 0.00189853390992511 0.00112556752776016 0.00299884872837589 0.998403584932082 0.997932147274224 0.998790673486123 0.24 0.148869217514897 0.352523956155022 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.18960828044961 0.658565216334832 2.05219795084074 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 17 42 6543 26463 0.00259146341463414 0.0015103251531184 0.00414595205096253 0.998415393322014 0.997858669093897 0.998857723591602 0.288135593220339 0.177648216049819 0.420769811304352 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.63704940940154 0.873076141666836 2.94030706523909 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1899G>C embA_c.1899G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1908C>T embA_c.1908C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1920C>T embA_c.1920C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1926C>T embA_c.1926C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1929C>T embA_c.1929C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1938G>C embA_c.1938G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1953G>A embA_c.1953G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1953G>C embA_c.1953G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1965C>T embA_c.1965C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1978C>T embA_c.1978C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1980G>A embA_c.1980G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1986C>T embA_c.1986C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 17 169 9464 35536 0.00179305980381816 0.00104485948824362 0.00286931523806543 0.995266769360033 0.994499014753107 0.995952161219926 0.0913978494623656 0.0541471228685394 0.142302759768771 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.37770786337013 0.214873255394234 0.623391257542311 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 14 140 6546 26365 0.00213414634146341 0.0011672334829473 0.00357814496544914 0.994717977740049 0.993769973164406 0.995554883511352 0.0909090909090909 0.0505955179171291 0.14782552221879 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 0 0.402765047357164 0.214521590389408 0.69929765985974 NA NA NA NA NA NA 54 5) Not assoc w R Now listed Silent mutation no 0 +Ethambutol embA c.198G>A embA_c.198G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.1995C>T embA_c.1995C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 9 7 9472 35698 0.000949266954962556 0.000434154257137837 0.00180123610483098 0.999803949026747 0.999596102051779 0.999921173824063 0.5625 0.298776899083177 0.802465859467332 NA NA NA NA NA NA NA NA NA NA NA NA False False 4.8455900096525 1.60525913734012 15.3158153316772 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 7 6 6553 26499 0.0010670731707317 0.000429122972600259 0.00219733487653492 0.99977362761743 0.99950734823901 0.999916920939814 0.538461538461538 0.251345482270303 0.807767558198712 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.71776285670685 1.35698246880563 16.9979360762971 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.-1delC embA_c.-1delC 1 upstream_gene_variant 4243231 0 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3301 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA c.2001G>A embA_c.2001G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 24 9481 35681 0 0 0.00038900558066021 0.999327825234561 0.999000021245735 0.999569278960296 0 0 0.142473597722525 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.625436057966667 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 24 6560 26481 0 0 0.000562171107654053 0.999094510469722 0.998653000996664 0.999419752318005 0 0 0.142473597722525 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.67091714745426 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2010C>T embA_c.2010C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2013C>A embA_c.2013C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 7 9481 35698 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.61285174975179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2013C>T embA_c.2013C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2016G>A embA_c.2016G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2031A>G embA_c.2031A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 1 9477 35704 0.000421896424427802 0.000114964157806894 0.00107986688593449 0.999971992718106 0.999843963402622 0.999999290917266 0.8 0.28358206388191 0.994949236620532 NA NA NA NA NA NA NA NA NA NA NA NA False False 15.0697478104885 1.49093500364622 739.038051857485 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 4 1 6556 26504 0.000609756097560975 0.000166162208307701 0.00156047520083291 0.999962271269571 0.999789807096406 0.999999044791703 0.8 0.28358206388191 0.994949236620532 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 16.1708358755338 1.59970034177407 792.771744020614 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2061T>C embA_c.2061T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2067A>C embA_c.2067A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2071C>T embA_c.2071C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2073G>A embA_c.2073G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2079C>G embA_c.2079C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2082G>C embA_c.2082G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 4 42 9477 35663 0.000421896424427802 0.000114964157806894 0.00107986688593449 0.998823694160481 0.99841030518573 0.999152094778215 0.0869565217391304 0.0242030708029345 0.207917324883947 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.358391494193963 0.0932913281699011 0.988170751374584 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 4 38 6556 26467 0.000609756097560975 0.000166162208307701 0.00156047520083291 0.998566308243727 0.998032671713558 0.998985240811267 0.0952380952380952 0.0265635696407603 0.226224871552779 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.424954240390482 0.110122420607121 1.18089391755576 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2088C>T embA_c.2088C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.208C>T embA_c.208C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 7 35 9474 35670 0.000738318742748655 0.00029689231210758 0.00152062336565454 0.999019745133734 0.998636963904226 0.999317124544511 0.166666666666666 0.069740663655675 0.313640866880671 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.753008233058898 0.282173174170832 1.72121812870034 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 5 26 6555 26479 0.000762195121951219 0.000247527523788107 0.00177780526826415 0.999019053008866 0.998563013375042 0.999359115925842 0.161290322580645 0.0545243262150835 0.337271584973179 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.776829196737663 0.232861174979789 2.05685885651246 NA NA NA NA NA NA 16 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2097A>G embA_c.2097A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.-20G>A embA_c.-20G>A 1 upstream_gene_variant 4243213 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3366 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2761 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 4 3) Uncertain significance No change no 1 +Ethambutol embA c.2112G>A embA_c.2112G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2124C>T embA_c.2124C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 2 9479 35703 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999943985436213 0.999797670939776 0.99999321630447 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.76653655448887 0.272970929153834 51.9466713138689 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 2 2 6558 26503 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999924542539143 0.999727448570663 0.999990861620785 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.04132357426044 0.292866339798886 55.7129032982466 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2127G>A embA_c.2127G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2133C>T embA_c.2133C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2136T>G embA_c.2136T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2142G>A embA_c.2142G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2148C>T embA_c.2148C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2160G>A embA_c.2160G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2175G>C embA_c.2175G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2188C>T embA_c.2188C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2199T>C embA_c.2199T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.21G>A embA_c.21G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2202G>A embA_c.2202G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2217G>A embA_c.2217G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2217G>T embA_c.2217G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2220G>C embA_c.2220G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2229C>T embA_c.2229C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.222C>A embA_c.222C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.222C>T embA_c.222C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2250G>A embA_c.2250G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.88306962025316 0.0319145727646777 36.1783621216076 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2256G>A embA_c.2256G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2259T>G embA_c.2259T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2262G>A embA_c.2262G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2265C>A embA_c.2265C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2271G>A embA_c.2271G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2280G>A embA_c.2280G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2280G>C embA_c.2280G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 7 9481 35698 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.61285174975179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 6 6560 26499 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.43165838346939 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.228C>T embA_c.228C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4803 8480 4678 27225 0.506592131631684 0.496475071292425 0.516705139853542 0.762498249544881 0.758048957583931 0.766904807257676 0.361590002258525 0.353412742128527 0.369827941557852 NA NA NA NA NA NA NA NA NA NA NA NA False True 3.2962823523599 3.14353977646622 3.45641018771156 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 3483 5422 3077 21083 0.530945121951219 0.518781125164318 0.543081590516264 0.795434823618185 0.790527429460727 0.800277367260559 0.391128579449747 0.380973730419882 0.401354706602617 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 1 4.40148142829074 4.1557240416339 4.6613336061026 NA NA NA NA NA NA 3186 5) Not assoc w R Now listed Silent mutation no 0 +Ethambutol embA c.2292G>C embA_c.2292G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.10982832991351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.-22delG embA_c.-22delG 1 upstream_gene_variant 4243210 0 0 0 0 5 1 9476 35704 0.000527370530534753 0.000171257241502832 0.00123027414547083 0.999971992718106 0.999843963402622 0.999999290917266 0.833333333333333 0.358765421002325 0.99578925548551 NA NA NA 0 0 0.975 NA NA NA NA 3385 4975 False False 18.8391726466863 2.10759583522104 886.708306345849 0 0 0.000389210799037296 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 5 1 6555 26504 0.000762195121951219 0.000247527523788107 0.00177780526826415 0.999962271269571 0.999789807096406 0.999999044791703 0.833333333333333 0.358765421002325 0.99578925548551 NA NA NA 0 0 0.975 NA NA NA NA 2780 4087 False False 0 0 0 0 0 0 0 20.2166285278413 2.26137738039683 951.169010205643 0 0 0.00056259979792051 0.999962271269571 0.999789807096406 0.999999044791703 3 3) Uncertain significance No change no 1 +Ethambutol embA c.-23_-22delCG embA_c.-23_-22delCG 1 upstream_gene_variant 4243209 2 3 0 3 1 3 9480 35702 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99991597815432 0.999754472342108 0.99998267234027 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11649128277037 1 2818.5 4975 False False 1.25534458509142 0.0239099774609589 15.6346568618898 0 0 0.00038904660702099 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 3 0 3 1 3 6559 26502 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999886813808715 0.999669257903365 0.999976657677988 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.78133043653875 1 2276.5 4087 False False 0 0 0 0 0 0 0 1.34685165421558 0.025651688752077 16.7753654027497 0 0 0.000562256793434776 0.999886813808715 0.999669257903365 0.999976657677988 1 3) Uncertain significance New Uncertain no 0 +Ethambutol embA c.2301C>T embA_c.2301C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2307C>A embA_c.2307C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.231G>T embA_c.231G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2322C>T embA_c.2322C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2331G>A embA_c.2331G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2334C>T embA_c.2334C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2340C>T embA_c.2340C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 2 9479 35703 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999943985436213 0.999797670939776 0.99999321630447 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.76653655448887 0.272970929153834 51.9466713138689 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2346G>A embA_c.2346G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 7 9480 35698 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999803949026747 0.999596102051779 0.999921173824063 0.125 0.0031597235312519 0.526509670875206 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.53794454490657 0.0119383062528594 4.18812953339448 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.40943166615857 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2349C>A embA_c.2349C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2358G>C embA_c.2358G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2364C>G embA_c.2364C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2374C>T embA_c.2374C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 11 9481 35694 0 0 0.00038900558066021 0.999691919899173 0.999448826618347 0.999846197812 0 0 0.284914152918154 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.50034693324555 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 11 6560 26494 0 0 0.000562171107654053 0.999584983965289 0.999257543293353 0.999792807866341 0 0 0.284914152918154 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.60965686204705 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2391G>C embA_c.2391G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2394G>A embA_c.2394G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.76624472573839 0.0479745002090283 294.932792118969 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.-23C>T embA_c.-23C>T 1 upstream_gene_variant 4243210 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3354 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA c.2409C>T embA_c.2409C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2424C>T embA_c.2424C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.19822685561766 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.40943166615857 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2439C>T embA_c.2439C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2442A>C embA_c.2442A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2442A>G embA_c.2442A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 19 9480 35686 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999467861644027 0.999169124220115 0.999679588507228 0.05 0.0012650894979498 0.248732762772027 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.198123473240062 0.00477141525199508 1.24666017256976 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 10 6560 26495 0 0 0.000562171107654053 0.999622712695717 0.999306265033238 0.999819061720012 0 0 0.30849710781876 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.80248078294835 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2442A>T embA_c.2442A>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.244C>T embA_c.244C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2457C>A embA_c.2457C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2469G>T embA_c.2469G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.246G>A embA_c.246G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2472G>A embA_c.2472G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 6 9480 35699 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99983195630864 0.999634275787128 0.999938328510354 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.627619549929676 0.0136468000350686 5.17448319653473 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 6 6559 26499 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.99977362761743 0.99950734823901 0.999916920939814 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.673349595974996 0.0146401601947477 5.55241977196973 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2475C>T embA_c.2475C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2481G>T embA_c.2481G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2490C>T embA_c.2490C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.-25_-24delAC embA_c.-25_-24delAC 1 upstream_gene_variant 4243207 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3274 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2685 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embA c.2523C>T embA_c.2523C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.76624472573839 0.0479745002090283 294.932792118969 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2532G>A embA_c.2532G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2538C>T embA_c.2538C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2544G>C embA_c.2544G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2553G>A embA_c.2553G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2553G>C embA_c.2553G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2556C>A embA_c.2556C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2580G>A embA_c.2580G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2586C>A embA_c.2586C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2586C>T embA_c.2586C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.258C>A embA_c.258C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2592G>A embA_c.2592G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 12 9481 35693 0 0 0.00038900558066021 0.99966391261728 0.999412996653316 0.999826327071809 0 0 0.264648469397051 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.35519147325258 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 11 6560 26494 0 0 0.000562171107654053 0.999584983965289 0.999257543293353 0.999792807866341 0 0 0.284914152918154 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.60965686204705 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2604G>A embA_c.2604G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.261C>T embA_c.261C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.262C>T embA_c.262C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2637C>T embA_c.2637C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2640C>T embA_c.2640C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.264G>A embA_c.264G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 10 9480 35695 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999719927181067 0.999484996631079 0.999865686288203 0.0909090909090909 0.00229897221381426 0.412779916988382 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.376529535864978 0.00867884780074745 2.64739955416065 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 10 6559 26495 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999622712695717 0.999306265033238 0.999819061720012 0.0909090909090909 0.00229897221381426 0.412779916988382 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.403948772678762 0.0093101143677691 2.84045345095752 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.264G>C embA_c.264G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2658C>T embA_c.2658C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2664C>T embA_c.2664C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2667C>G embA_c.2667C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2667C>T embA_c.2667C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 4 1 9477 35704 0.000421896424427802 0.000114964157806894 0.00107986688593449 0.999971992718106 0.999843963402622 0.999999290917266 0.8 0.28358206388191 0.994949236620532 NA NA NA NA NA NA NA NA NA NA NA NA False False 15.0697478104885 1.49093500364622 739.038051857485 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 2 1 6558 26504 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999962271269571 0.999789807096406 0.999999044791703 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 8.08295211954864 0.420719628662148 475.373667785977 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2676G>A embA_c.2676G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.-26delA embA_c.-26delA 1 upstream_gene_variant 4243206 1 1 1 0 9 3 9472 35702 0.000949266954962556 0.000434154257137837 0.00180123610483098 0.99991597815432 0.999754472342108 0.99998267234027 0.75 0.42814153812181 0.945139355472007 1 0.025 1 0.25 0.00630946320970987 0.805879550316756 Inf 0.0966362415515216 Inf 0.209695628112894 168 4975 False False 11.307643581081 2.82107016121258 65.0332616697363 0.000105563179562968 2.67262473891848e-06 0.000588018489085019 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 6 2 6554 26503 0.000914634146341463 0.000335726224038477 0.00198970246660848 0.999924542539143 0.999727448570663 0.999990861620785 0.75 0.349144205587175 0.968145973750055 1 0.025 1 0.333333333333333 0.00840375865961264 0.905700675949754 Inf 0.103671030737802 Inf 0.19828785770464 123 4087 False False 0 0 0 0 0 0 0 12.1313701556301 2.1683237669748 123.038341532173 0.00015255530129672 3.86235836629056e-06 0.000849687394050823 0.999924542539143 0.999727448570663 0.999990861620785 5 3) Uncertain significance New Uncertain no 0 +Ethambutol embA c.2703G>C embA_c.2703G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2706C>T embA_c.2706C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.10982832991351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.40943166615857 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2724G>A embA_c.2724G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2733A>G embA_c.2733A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2742C>A embA_c.2742C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2769C>G embA_c.2769C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.276A>C embA_c.276A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2787G>A embA_c.2787G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2787G>C embA_c.2787G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2796G>C embA_c.2796G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 2 9479 35703 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999943985436213 0.999797670939776 0.99999321630447 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.76653655448887 0.272970929153834 51.9466713138689 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 2 2 6558 26503 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999924542539143 0.999727448570663 0.999990861620785 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.04132357426044 0.292866339798886 55.7129032982466 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2799G>A embA_c.2799G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.279G>C embA_c.279G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.-27T>C embA_c.-27T>C 1 upstream_gene_variant 4243206 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA c.2802G>T embA_c.2802G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.19822685561766 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 6 6560 26499 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.43165838346939 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2805G>A embA_c.2805G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2814G>A embA_c.2814G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2823T>C embA_c.2823T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2835C>T embA_c.2835C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2838G>A embA_c.2838G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2844G>C embA_c.2844G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2844G>T embA_c.2844G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2853G>A embA_c.2853G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2856A>G embA_c.2856A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 21 112 9460 35593 0.00221495622824596 0.00137159943312054 0.00338381350894567 0.996863184427951 0.996226799682733 0.997416475853179 0.157894736842105 0.100476509930532 0.231176088123725 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.705463794926004 0.420061126355569 1.13207247277232 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 12 85 6548 26420 0.00182926829268292 0.000945555636841848 0.00319318105848117 0.996793057913601 0.996036071107748 0.997437629523626 0.123711340206185 0.0655874383951639 0.206129590616395 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 0 0.569621617736893 0.283015200248597 1.04848534584615 NA NA NA NA NA NA 5 5) Not assoc w R Now listed Silent mutation no 0 +Ethambutol embA c.285C>T embA_c.285C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2865C>T embA_c.2865C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2871C>G embA_c.2871C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2874G>T embA_c.2874G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2889G>C embA_c.2889G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.-28delT embA_c.-28delT 1 upstream_gene_variant 4243204 1 1 0 1 11 5 9470 35700 0.00116021516717645 0.00057931301275248 0.00207499495108562 0.999859963590533 0.999673232250017 0.999954529045718 0.6875 0.413379363548641 0.889830045282882 0 0 0.975 0 0 0.521823750104981 0 0 146.691593095544 1 2818.5 4975 False False 8.2935586061246 2.6555370920474 30.4344624843374 0 0 0.000389457347082932 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 5 2 6555 26503 0.000762195121951219 0.000247527523788107 0.00177780526826415 0.999924542539143 0.999727448570663 0.999990861620785 0.714285714285714 0.290420863737342 0.963307433823914 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2828 4087 False False 0 0 0 0 0 0 0 10.1079328756674 1.6542054319611 106.199585900179 0 0 0.00056259979792051 0.999924542539143 0.999727448570663 0.999990861620785 2 3) Uncertain significance New Uncertain no 0 +Ethambutol embA c.-28T>G embA_c.-28T>G 1 upstream_gene_variant 4243205 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA c.-29_-28delCT embA_c.-29_-28delCT 1 upstream_gene_variant 4243203 0 0 0 0 18 0 9463 35705 0.00189853390992511 0.00112556752776016 0.00299884872837589 1 0.999896689850119 1 1 0.814698031862147 1 NA NA NA NA NA NA NA NA NA NA 3302 4975 False False Inf 16.5755324562062 Inf 0 0 0.00038974538154329 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 16 0 6544 26505 0.0024390243902439 0.00139473586445882 0.00395780883041526 1 0.999860832946126 1 1 0.794092785792177 1 NA NA NA NA NA NA NA NA NA NA 2710 4087 False False 0 0 0 0 0 0 0 Inf 15.6166029346637 Inf 0 0 0.000563545221770202 1 0.999860832946126 1 10 3) Uncertain significance New Uncertain no 0 +Ethambutol embA c.2910G>A embA_c.2910G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2913C>T embA_c.2913C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2919A>G embA_c.2919A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 8 9481 35697 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.20624116275339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 7 6560 26498 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.80327602229365 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2922G>A embA_c.2922G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2928G>A embA_c.2928G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2932T>C embA_c.2932T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.294G>A embA_c.294G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.10982832991351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.40943166615857 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2955C>T embA_c.2955C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 0 NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2961C>T embA_c.2961C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2970G>A embA_c.2970G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2982C>G embA_c.2982C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.2988T>C embA_c.2988T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.-29C>G embA_c.-29C>G 1 upstream_gene_variant 4243204 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA c.-29C>T embA_c.-29C>T 1 upstream_gene_variant 4243204 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA c.3000C>T embA_c.3000C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.3003G>A embA_c.3003G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.300C>A embA_c.300C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 20 9481 35685 0 0 0.00038900558066021 0.999439854362134 0.999135032404509 0.999657815983264 0 0 0.168433470983085 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.762572985704327 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 19 6560 26486 0 0 0.000562171107654053 0.999283154121863 0.998880781714398 0.999568358524102 0 0 0.176466911806965 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.865443021143955 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.300C>T embA_c.300C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 13 9479 35692 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999635905335387 0.999377467513205 0.999806121137399 0.133333333333333 0.0165759134400836 0.404602696603372 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.579288629926882 0.0634555870290756 2.55961742801428 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 2 8 6558 26497 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999698170156574 0.999405361976814 0.999869682578628 0.2 0.0252107263268333 0.556095462307641 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.01010216529429 0.104463368269269 5.06308595441747 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.3033C>T embA_c.3033C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.76624472573839 0.0479745002090283 294.932792118969 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.3045G>A embA_c.3045G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 15 9479 35690 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.9995798907716 0.999307188228015 0.999764849596654 0.117647058823529 0.0145793168403025 0.36440916210125 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.502022013573865 0.0557002109362417 2.1594541115419 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 10 6559 26495 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999622712695717 0.999306265033238 0.999819061720012 0.0909090909090909 0.00229897221381426 0.412779916988382 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.403948772678762 0.0093101143677691 2.84045345095752 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.3048G>T embA_c.3048G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.3078C>T embA_c.3078C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 7 9481 35698 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.61285174975179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 7 6560 26498 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.80327602229365 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.3093G>A embA_c.3093G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 4 9480 35701 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999887970872426 0.999713186009257 0.999969475016731 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.941482067510548 0.0191153149568561 9.51304376083015 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.3093G>C embA_c.3093G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.3099C>T embA_c.3099C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.309C>A embA_c.309C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.309C>G embA_c.309C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.309C>T embA_c.309C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 18 9480 35687 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99949586892592 0.999203372130377 0.999701193476901 0.0526315789473684 0.00133162880417942 0.260280654195214 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.20913619315518 0.00502263873391001 1.32494056057363 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 17 6559 26488 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.99935861158272 0.998973272974466 0.999626324627714 0.0555555555555555 0.00140555616736942 0.272943599673368 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.237554146525205 0.00568691332380032 1.51658119210468 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.-30C>T embA_c.-30C>T 1 upstream_gene_variant 4243203 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3475 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2864 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA c.3108G>A embA_c.3108G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.3123G>A embA_c.3123G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.3132G>A embA_c.3132G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 2 9479 35703 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999943985436213 0.999797670939776 0.99999321630447 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.76653655448887 0.272970929153834 51.9466713138689 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 2 2 6558 26503 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999924542539143 0.999727448570663 0.999990861620785 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.04132357426044 0.292866339798886 55.7129032982466 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.3138G>A embA_c.3138G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.3144G>A embA_c.3144G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.3147C>T embA_c.3147C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.3156C>T embA_c.3156C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.3177G>A embA_c.3177G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.3183C>T embA_c.3183C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.3187C>T embA_c.3187C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.3192G>A embA_c.3192G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.10982832991351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.-31delC embA_c.-31delC 1 upstream_gene_variant 4243201 1 1 0 1 12 4 9469 35701 0.0012656892732834 0.000654165731961641 0.0022098595784263 0.999887970872426 0.999713186009257 0.999969475016731 0.75 0.476229180103872 0.927337961747117 0 0 0.975 0 0 0.602364635616474 0 0 146.711149262205 1 2818.5 4975 False False 11.3109092829232 3.4268371595443 48.1430621324724 0 0 0.00038949846879491 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 7 2 6553 26503 0.0010670731707317 0.000429122972600259 0.00219733487653492 0.999924542539143 0.999727448570663 0.999990861620785 0.777777777777777 0.399906426283687 0.971855026522101 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2788 4087 False False 0 0 0 0 0 0 0 14.1554249961849 2.69423273688032 139.942735490417 0 0 0.000562771457148547 0.999924542539143 0.999727448570663 0.999990861620785 3 3) Uncertain significance New Uncertain no 0 +Ethambutol embA c.-32_-31delGCinsT embA_c.-32_-31delGCinsT 1 upstream_gene_variant 4243201 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3313 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethambutol embA c.3210A>G embA_c.3210A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.3222C>T embA_c.3222C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.3243G>A embA_c.3243G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.3249C>A embA_c.3249C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 0 NA NA NA 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.76624472573839 0.0479745002090283 294.932792118969 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.3255T>C embA_c.3255T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.3255T>G embA_c.3255T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.3264A>G embA_c.3264A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.3267G>T embA_c.3267G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.3276G>A embA_c.3276G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 17 282 9464 35423 0.00179305980381816 0.00104485948824362 0.00286931523806543 0.992101946506091 0.991128603128548 0.992993911328525 0.0568561872909698 0.0334660375596954 0.0894734588596638 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.225637053889918 0.129539854523123 0.368047174114799 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 10 142 6550 26363 0.00152439024390243 0.000731238785140689 0.00280161526425175 0.994642520279192 0.993688364644751 0.995485615255712 0.0657894736842105 0.0319968773560471 0.117660029416418 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 1 0.283442640576282 0.13297002663551 0.537107166368807 NA NA NA NA NA NA 42 5) Not assoc w R Now listed Silent mutation no 0 +Ethambutol embA c.3277C>T embA_c.3277C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.10982832991351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.40943166615857 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.327C>T embA_c.327C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.-32delG embA_c.-32delG 1 upstream_gene_variant 4243200 1 1 0 1 9 1 9472 35704 0.000949266954962556 0.000434154257137837 0.00180123610483098 0.999971992718106 0.999843963402622 0.999999290917266 0.9 0.554983882971804 0.997471421455538 0 0 0.975 0 0 0.975 0 0 146.677084792939 1 2818.5 4975 False False 33.924831081081 4.69887939071575 1475.41340719747 0 0 0.000389375129702287 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 9 0 6551 26505 0.00137195121951219 0.000627529309645025 0.00260278604702639 1 0.999860832946126 1 1 0.663732883120057 1 NA NA NA NA NA NA NA NA NA NA 2748 4087 False False 0 0 0 0 0 0 0 Inf 7.98180213517408 Inf 0 0 0.000562943221161135 1 0.999860832946126 1 7 3) Uncertain significance New Uncertain no 0 +Ethambutol embA c.-32G>A embA_c.-32G>A 1 upstream_gene_variant 4243201 1 3 0 3 1 4 9480 35701 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999887970872426 0.999713186009257 0.999969475016731 0.2 0.00505076337946806 0.716417936118089 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.11623600185219 1 1480 4975 False False 0.941482067510548 0.0191153149568561 9.51304376083015 0 0 0.00038904660702099 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 4 6559 26501 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999849085078287 0.999613643356053 0.999958879281354 0.2 0.00505076337946806 0.716417936118089 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.780961496544 1 2276.5 4087 False False 0 0 0 0 0 0 0 1.01010062509528 0.0205075656450505 10.2127021503241 0 0 0.000562256793434776 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA c.-32G>T embA_c.-32G>T 1 upstream_gene_variant 4243201 0 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3489 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2876 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA c.-33_-32delCG embA_c.-33_-32delCG 1 upstream_gene_variant 4243199 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA c.345C>T embA_c.345C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.348G>A embA_c.348G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 15 874 9466 34831 0.00158211159160426 0.000885757734327454 0.00260811203671776 0.975521635625262 0.973865570581232 0.977099721141109 0.0168728908886389 0.00947359258986739 0.0276767689270971 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.0631508600454184 0.0351793050099173 0.104806583580078 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 11 828 6549 25677 0.00167682926829268 0.000837354988859942 0.00299832542833478 0.968760611205432 0.966595355158332 0.970822279301341 0.0131108462455303 0.00656256581813898 0.0233375984253585 NA NA NA NA NA NA NA NA NA NA NA NA False True 1 1 1 0 0 0 1 0.052087275189707 0.025888461234692 0.0937737305247245 NA NA NA NA NA NA 44 5) Not assoc w R Now listed Silent mutation no 0 +Ethambutol embA c.-34C>T embA_c.-34C>T 1 upstream_gene_variant 4243199 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA c.-34delC embA_c.-34delC 1 upstream_gene_variant 4243198 0 0 0 0 3 1 9478 35704 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999971992718106 0.999843963402622 0.999999290917266 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 3355 4975 False False 11.3011183794049 0.90722384791697 591.183089908516 0 0 0.000389128685709026 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2751 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 4 3) Uncertain significance No change no 1 +Ethambutol embA c.-35delA embA_c.-35delA 1 upstream_gene_variant 4243197 0 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3469 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 2 1 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 4.04085988717792 0.0514701624188962 316.380494544091 0.35743759524028 195 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA c.-36_-35delCA embA_c.-36_-35delCA 1 upstream_gene_variant 4243196 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3476 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2865 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 3 3) Uncertain significance New Uncertain no 0 +Ethambutol embA c.366G>A embA_c.366G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 45 8 9436 35697 0.00474633477481278 0.00346405306999212 0.00634587080230341 0.999775941744853 0.999558563909973 0.999903262744512 0.849056603773584 0.724078821145283 0.932507461884036 NA NA NA NA NA NA NA NA NA NA NA NA False False 21.2797398261975 9.92406523175706 52.2507847358781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 38 5 6522 26500 0.00579268292682926 0.00410241205405612 0.00794232427340546 0.999811356347858 0.999559824020536 0.9999387451734 0.883720930232558 0.749167574654347 0.961147685221938 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 30.8800981294081 12.1279879849951 100.582621259465 NA NA NA NA NA NA 15 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.36C>A embA_c.36C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.-36C>T embA_c.-36C>T 1 upstream_gene_variant 4243197 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA c.-37delT embA_c.-37delT 1 upstream_gene_variant 4243195 0 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3490 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2877 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA c.-38_-37delCT embA_c.-38_-37delCT 1 upstream_gene_variant 4243194 0 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3392 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2789 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embA c.381C>A embA_c.381C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.387C>T embA_c.387C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.-39_-31delCCTCACCGC embA_c.-39_-31delCCTCACCGC 1 upstream_gene_variant 4243193 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3444 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2839 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA c.390G>A embA_c.390G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 7 9481 35698 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.61285174975179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 7 6560 26498 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.80327602229365 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.390G>T embA_c.390G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.393C>T embA_c.393C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.-39delC embA_c.-39delC 1 upstream_gene_variant 4243193 0 0 0 0 3 1 9478 35704 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999971992718106 0.999843963402622 0.999999290917266 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 3303 4975 False False 11.3011183794049 0.90722384791697 591.183089908516 0 0 0.000389128685709026 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 1 6557 26504 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 0.999962271269571 0.999789807096406 0.999999044791703 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 2711 4087 False False 0 0 0 0 0 0 0 12.1262772609425 0.973374031902014 634.171386087929 0 0 0.000562428243381166 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA c.-3C>T embA_c.-3C>T 1 upstream_gene_variant 4243230 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embA c.405C>T embA_c.405C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.408T>C embA_c.408T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.-40delT embA_c.-40delT 1 upstream_gene_variant 4243192 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12104088004766 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol embA c.-41_-40delAT embA_c.-41_-40delAT 1 upstream_gene_variant 4243191 0 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3433 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2829 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA c.-41A>C embA_c.-41A>C 1 upstream_gene_variant 4243192 2 1 0 1 10 1 9471 35704 0.0010547410610695 0.00050590153672643 0.00193884812290577 0.999971992718106 0.999843963402622 0.999999290917266 0.909090909090909 0.587220083011617 0.997701027786185 0 0 0.975 0 0 0.975 0 0 146.692536264855 1 2818.5 4975 False False 37.6982367226269 5.3615744614967 1622.0617901274 0 0 0.000389416234052975 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 0 1 10 1 6550 26504 0.00152439024390243 0.000731238785140689 0.00280161526425175 0.999962271269571 0.999789807096406 0.999999044791703 0.909090909090909 0.587220083011617 0.997701027786185 0 0 0.975 0 0 0.975 0 0 157.430286898767 1 2276.5 4087 False False 0 0 0 0 0 0 0 40.4641221374045 5.75385852961741 1739.82431593249 0 0 0.000563029142491623 0.999962271269571 0.999789807096406 0.999999044791703 2 3) Uncertain significance No change no 1 +Ethambutol embA c.-41delA embA_c.-41delA 1 upstream_gene_variant 4243191 1 1 0 1 13 1 9468 35704 0.00137116337939035 0.000730282374626527 0.00234358976784705 0.999971992718106 0.999843963402622 0.999999290917266 0.928571428571428 0.661315510068178 0.998193219340874 0 0 0.975 0 0 0.975 0 0 146.738910219317 1 1480 4975 False False 49.0232361639205 7.36241777084246 2060.63684291456 0 0 0.000389539599191658 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA c.-42delC embA_c.-42delC 1 upstream_gene_variant 4243190 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3275 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2686 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA c.435C>G embA_c.435C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.435C>T embA_c.435C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.-43delG embA_c.-43delG 1 upstream_gene_variant 4243189 1 3 1 2 6 2 9475 35703 0.000632844636641704 0.000232277107744303 0.00137692358870305 0.999943985436213 0.999797670939776 0.99999321630447 0.75 0.349144205587175 0.968145973750055 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 1.88406332453825 0.0319314125264138 36.1976009931172 0.506471835805059 349 4975 False False 11.3043799472295 2.02076681289593 114.60971106128 0.000105529759392148 2.67177861571188e-06 0.000587832373640432 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 5 2 6555 26503 0.000762195121951219 0.000247527523788107 0.00177780526826415 0.999924542539143 0.999727448570663 0.999990861620785 0.714285714285714 0.290420863737342 0.963307433823914 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 2.02158657513348 0.0342605928355023 38.8002383713601 0.484740840568154 237 4087 False False 0 0 0 0 0 0 0 10.1079328756674 1.6542054319611 106.199585900179 0.000152532031726662 3.86176923405925e-06 0.000849557834692023 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance New Uncertain no 0 +Ethambutol embA c.-43delGinsCC embA_c.-43delGinsCC 1 upstream_gene_variant 4243190 1 7 4 3 5 3 9476 35702 0.000527370530534753 0.000171257241502832 0.00123027414547083 0.99991597815432 0.999754472342108 0.99998267234027 0.625 0.244863216366551 0.914766585862746 0.571428571428571 0.184051567640083 0.901011721557492 0.571428571428571 0.184051567640083 0.901011721557492 5.02349795975798 0.849681536261718 34.2823503495458 0.0392679459248647 81 4975 False False 6.27937244969748 1.22138615315282 40.4465543492688 0.000421940928270042 0.000114976286049805 0.00107998075844169 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 4 3 5 3 6555 26502 0.000762195121951219 0.000247527523788107 0.00177780526826415 0.999886813808715 0.999669257903365 0.999976657677988 0.625 0.244863216366551 0.914766585862746 0.571428571428571 0.184051567640083 0.901011721557492 0.571428571428571 0.184051567640083 0.901011721557492 5.3906941266209 0.911672104423667 36.8053574984865 0.0324040414689056 56 4087 False False 0 0 0 0 0 0 0 6.73836765827612 1.31049304610532 43.4121450586851 0.000609849062357066 0.000166187545464602 0.00156071300120446 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embA c.-43G>C embA_c.-43G>C 1 upstream_gene_variant 4243190 1 49 17 32 124 44 9357 35661 0.0130787891572618 0.0108897018948276 0.0155740918632424 0.998767679596695 0.99834601650568 0.99910445575133 0.738095238095238 0.66478658585541 0.802801531542886 0.346938775510204 0.21672437810748 0.496387197719464 0.278688524590163 0.17147208426028 0.408287466756179 2.02467738057069 1.0539912446946 3.75857115311699 0.0216480993179244 70 4975 False False 10.7405345536156 7.55070111097376 15.5275079544821 0.00181352677618946 0.00105678997266825 0.00290204931954029 0.998767679596695 0.99834601650568 0.99910445575133 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 33 16 17 88 26 6472 26479 0.0134146341463414 0.010772453178703 0.0165014262439907 0.999019053008866 0.998563013375042 0.999359115925842 0.771929824561403 0.683951588388766 0.845285233337094 0.484848484848484 0.307963443604732 0.664555521611444 0.380952380952381 0.235720546863216 0.543632504502101 3.85065076710535 1.81948942888054 8.10999790922703 0.000183956848341404 23 4087 True False 0 0 0 0 0 0 0 13.8475325663211 8.84466004517993 22.3851368215462 0.00246609124537607 0.00141022081452423 0.00400169643947794 0.999019053008866 0.998563013375042 0.999359115925842 45 3) Uncertain significance No change no 1 +Ethambutol embA c.-43G>T embA_c.-43G>T 1 upstream_gene_variant 4243190 1 1 0 1 7 3 9474 35702 0.000738318742748655 0.00029689231210758 0.00152062336565454 0.99991597815432 0.999754472342108 0.99998267234027 0.7 0.347547149940002 0.933260488822265 0 0 0.975 0 0 0.707598226178713 0 0 146.637996110646 1 2818.5 4975 False False 8.79297727112799 2.00679427251216 52.716257751683 0 0 0.000389292947027732 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 5 0 6555 26505 0.000762195121951219 0.000247527523788107 0.00177780526826415 1 0.999860832946126 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 2808 4087 False False 0 0 0 0 0 0 0 Inf 3.70403509656001 Inf 0 0 0.00056259979792051 1 0.999860832946126 1 2 3) Uncertain significance No change no 1 +Ethambutol embA c.-44_-43delCG embA_c.-44_-43delCG 1 upstream_gene_variant 4243188 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3424 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2816 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embA c.474C>T embA_c.474C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.477C>T embA_c.477C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.486G>A embA_c.486G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.489G>A embA_c.489G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.-48G>C embA_c.-48G>C 1 upstream_gene_variant 4243185 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA c.492G>A embA_c.492G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.88306962025316 0.0319145727646777 36.1783621216076 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.495G>A embA_c.495G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.498G>A embA_c.498G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.-4C>A embA_c.-4C>A 1 upstream_gene_variant 4243229 0 0 0 0 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3283 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2693 4087 False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 0 0 0.000562256793434776 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance New Uncertain no 0 +Ethambutol embA c.-4C>T embA_c.-4C>T 1 upstream_gene_variant 4243229 1 2 0 2 10 3 9471 35702 0.0010547410610695 0.00050590153672643 0.00193884812290577 0.99991597815432 0.999754472342108 0.99998267234027 0.769230769230769 0.461868460765959 0.949618926508848 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.0800184227801 1 2818.5 4975 False False 12.5653750043993 3.23416188407051 71.0591943205432 0 0 0.000389416234052975 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 7 2 6553 26503 0.0010670731707317 0.000429122972600259 0.00219733487653492 0.999924542539143 0.999727448570663 0.999990861620785 0.777777777777777 0.399906426283687 0.971855026522101 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.5410895909416 1 2276.5 4087 False False 0 0 0 0 0 0 0 14.1554249961849 2.69423273688032 139.942735490417 0 0 0.000562771457148547 0.999924542539143 0.999727448570663 0.999990861620785 3 3) Uncertain significance No change no 1 +Ethambutol embA c.-4delC embA_c.-4delC 1 upstream_gene_variant 4243228 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3284 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2694 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA c.501G>A embA_c.501G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 5 9479 35700 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999859963590533 0.999673232250017 0.999954529045718 0.285714285714285 0.0366925661760855 0.709579136262657 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.50648802616309 0.143410178089837 9.20379905242336 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 2 3 6558 26502 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999886813808715 0.999669257903365 0.999976657677988 0.4 0.0527449505263169 0.853367200365326 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.69411405916437 0.224966079471659 23.5225659748306 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.510T>C embA_c.510T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.-51G>A embA_c.-51G>A 1 upstream_gene_variant 4243182 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA c.-51G>T embA_c.-51G>T 1 upstream_gene_variant 4243182 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3393 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2790 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA c.529C>T embA_c.529C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.531G>C embA_c.531G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.534G>A embA_c.534G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.543G>A embA_c.543G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.555G>A embA_c.555G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.564C>T embA_c.564C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 9 9481 35696 0 0 0.00038900558066021 0.99974793446296 0.999521555266748 0.999884733314884 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.90786321657339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 8 6560 26497 0 0 0.000562171107654053 0.999698170156574 0.999405361976814 0.999869682578628 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.36695385477914 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.576C>T embA_c.576C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.57C>T embA_c.57C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.582G>A embA_c.582G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 7 9481 35698 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.61285174975179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 7 6560 26498 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.80327602229365 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.591G>A embA_c.591G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.-59C>A embA_c.-59C>A 1 upstream_gene_variant 4243174 1 8 0 8 4 12 9477 35693 0.000421896424427802 0.000114964157806894 0.00107986688593449 0.99966391261728 0.999412996653316 0.999826327071809 0.25 0.0726620382528822 0.523770819896127 0 0 0.369416647552819 0 0 0.264648469397051 0 0 2.20692559302394 0.217708294764205 235 4975 False False 1.25542541591924 0.295037488647637 4.14356889249059 0 0 0.000389169738041761 0.99966391261728 0.999412996653316 0.999826327071809 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 3 9 6557 26496 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 0.999660441426146 0.999355510362951 0.999844720818052 0.25 0.0548606445279927 0.571858461878189 0 0 0.409616397225003 0 0 0.336267116879942 0 0 2.80434701271979 0.357914711586302 217 4087 False False 0 0 0 0 0 0 0 1.34695745005337 0.234479688503756 5.39893908273865 0 0 0.000562428243381166 0.999660441426146 0.999355510362951 0.999844720818052 3 3) Uncertain significance No change no 1 +Ethambutol embA c.-5G>A embA_c.-5G>A 1 upstream_gene_variant 4243228 0 0 0 0 5 1 9476 35704 0.000527370530534753 0.000171257241502832 0.00123027414547083 0.999971992718106 0.999843963402622 0.999999290917266 0.833333333333333 0.358765421002325 0.99578925548551 NA NA NA 0 0 0.975 NA NA NA NA 3394 4975 False False 18.8391726466863 2.10759583522104 886.708306345849 0 0 0.000389210799037296 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 1 6556 26504 0.000609756097560975 0.000166162208307701 0.00156047520083291 0.999962271269571 0.999789807096406 0.999999044791703 0.8 0.28358206388191 0.994949236620532 NA NA NA 0 0 0.975 NA NA NA NA 2791 4087 False False 0 0 0 0 0 0 0 16.1708358755338 1.59970034177407 792.771744020614 0 0 0.000562514007570737 0.999962271269571 0.999789807096406 0.999999044791703 3 3) Uncertain significance No change no 1 +Ethambutol embA c.-5G>T embA_c.-5G>T 1 upstream_gene_variant 4243228 1 1 1 0 10 5 9471 35700 0.0010547410610695 0.00050590153672643 0.00193884812290577 0.999859963590533 0.999673232250017 0.999954529045718 0.666666666666666 0.383803732541154 0.881758896633119 1 0.025 1 0.166666666666666 0.00421074451448947 0.641234578997674 Inf 0.0966410298031812 Inf 0.209687416983972 167 4975 False False 7.53880266075388 2.34688833388164 28.0942294435112 0.000105574324324324 2.67290689909237e-06 0.00058808055375891 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 9 5 6551 26500 0.00137195121951219 0.000627529309645025 0.00260278604702639 0.999811356347858 0.999559824020536 0.9999387451734 0.642857142857142 0.351380110615991 0.87240157014084 1 0.025 1 0.166666666666666 0.00421074451448947 0.641234578997674 Inf 0.103706758828869 Inf 0.198233087256444 121 4087 False False 0 0 0 0 0 0 0 7.28133109448939 2.19034699191626 27.6601649946161 0.000152625152625152 3.86412684197919e-06 0.000850076309332636 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA c.600C>T embA_c.600C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.603G>A embA_c.603G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.606C>G embA_c.606C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.609G>A embA_c.609G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.615C>T embA_c.615C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.636G>A embA_c.636G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.639G>A embA_c.639G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.643C>T embA_c.643C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 6 9480 35699 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99983195630864 0.999634275787128 0.999938328510354 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.627619549929676 0.0136468000350686 5.17448319653473 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.645G>A embA_c.645G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.648A>C embA_c.648A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.648A>G embA_c.648A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 5 9479 35700 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999859963590533 0.999673232250017 0.999954529045718 0.285714285714285 0.0366925661760855 0.709579136262657 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.50648802616309 0.143410178089837 9.20379905242336 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 5 6559 26500 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999811356347858 0.999559824020536 0.9999387451734 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.808050007623113 0.0170817619606711 7.22310074751644 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.651C>T embA_c.651C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.657G>A embA_c.657G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.666C>G embA_c.666C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.672G>A embA_c.672G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.684C>T embA_c.684C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.687G>A embA_c.687G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.6C>A embA_c.6C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.726G>A embA_c.726G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.735G>A embA_c.735G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.747C>T embA_c.747C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.759T>G embA_c.759T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 23 9481 35682 0 0 0.00038900558066021 0.999355832516454 0.999033588308985 0.99959161063274 0 0 0.148185128915224 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.654879044307434 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.-75G>A embA_c.-75G>A 1 upstream_gene_variant 4243158 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA c.-75G>C embA_c.-75G>C 1 upstream_gene_variant 4243158 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethambutol embA c.768G>A embA_c.768G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.-76G>A embA_c.-76G>A 1 upstream_gene_variant 4243157 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA c.-76G>C embA_c.-76G>C 1 upstream_gene_variant 4243157 1 9 0 9 1 10 9480 35695 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999719927181067 0.999484996631079 0.999865686288203 0.0909090909090909 0.00229897221381426 0.412779916988382 0 0 0.336267116879942 0 0 0.30849710781876 0 0 1.90801105313921 0.219222143410004 242 4975 False False 0.376529535864978 0.00867884780074745 2.64739955416065 0 0 0.00038904660702099 0.999719927181067 0.999484996631079 0.999865686288203 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 1 9 6559 26496 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999660441426146 0.999355510362951 0.999844720818052 0.1 0.00252857854446178 0.445016117028195 0 0 0.369416647552819 0 0 0.336267116879942 0 0 2.36722545919145 0.369978765148518 223.5 4087 False False 0 0 0 0 0 0 0 0.448848909894801 0.0102423495192947 3.24032619577018 0 0 0.000562256793434776 0.999660441426146 0.999355510362951 0.999844720818052 19 3) Uncertain significance No change no 1 +Ethambutol embA c.774C>T embA_c.774C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.777G>C embA_c.777G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.783G>A embA_c.783G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.784T>C embA_c.784T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 15 9480 35690 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.9995798907716 0.999307188228015 0.999764849596654 0.0625 0.00158111172276588 0.302320738434531 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.25098452883263 0.0059648899607233 1.63179223830413 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 14 6559 26491 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999471797774004 0.999113925067086 0.999711197799087 0.0666666666666666 0.0016864302413527 0.319484566578303 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.288491276980375 0.0068252589969484 1.89684270073588 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.-78delG embA_c.-78delG 1 upstream_gene_variant 4243154 1 1 1 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.096562813829025 Inf 0.209821626167397 198.5 4975 False False Inf 0.096562813829025 Inf 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.103599830448027 Inf 0.198397096627854 142 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA c.78G>T embA_c.78G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.798C>T embA_c.798C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.-7G>A embA_c.-7G>A 1 upstream_gene_variant 4243226 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3381 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2776 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA c.807C>T embA_c.807C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.813G>A embA_c.813G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.813G>T embA_c.813G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.825C>A embA_c.825C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.825C>G embA_c.825C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.-82T>C embA_c.-82T>C 1 upstream_gene_variant 4243151 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embA c.837C>T embA_c.837C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.-83G>A embA_c.-83G>A 1 upstream_gene_variant 4243150 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA c.855G>A embA_c.855G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 13 9481 35692 0 0 0.00038900558066021 0.999635905335387 0.999377467513205 0.999806121137399 0 0 0.24705263800047 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.2354962611609 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 10 6560 26495 0 0 0.000562171107654053 0.999622712695717 0.999306265033238 0.999819061720012 0 0 0.30849710781876 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.80248078294835 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.-85delA embA_c.-85delA 1 upstream_gene_variant 4243147 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3329 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA c.861C>G embA_c.861C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.864C>T embA_c.864C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 20 871 9461 34834 0.00210948212213901 0.00128898780543425 0.00325605306957067 0.975605657470942 0.973952268490739 0.977181051659754 0.0224466891133557 0.0137636573990832 0.0344550084103607 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.0845430955844957 0.0513703061596328 0.131496794657723 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 17 621 6543 25884 0.00259146341463414 0.0015103251531184 0.00414595205096253 0.976570458404074 0.974677454291999 0.978357964101363 0.0266457680250783 0.0155970711122125 0.0423204828846885 NA NA NA NA NA NA NA NA NA NA NA NA False True 1 1 1 0 0 0 1 0.108295844436027 0.0626351272081423 0.175007024071986 NA NA NA NA NA NA 4 5) Not assoc w R Now listed Silent mutation no 0 +Ethambutol embA c.867T>C embA_c.867T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.19822685561766 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 6 6560 26499 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.43165838346939 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.870A>G embA_c.870A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.885G>T embA_c.885G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.-8C>A embA_c.-8C>A 1 upstream_gene_variant 4243225 1 35 6 29 31 44 9450 35661 0.00326969728931547 0.00222264895937465 0.00463789095997725 0.998767679596695 0.99834601650568 0.99910445575133 0.413333333333333 0.300753633689051 0.532972858659621 0.171428571428571 0.0656218011562506 0.336498300018197 0.12 0.0453353207736638 0.243101316705562 0.780755336617405 0.264975432153668 1.91457692697045 0.682050084351217 532 4975 False False 2.65870851370851 1.62207164255385 4.30904976627811 0.000634517766497461 0.000232891298435421 0.00138056257328183 0.998767679596695 0.99834601650568 0.99910445575133 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 30 6 24 29 37 6531 26468 0.00442073170731707 0.00296257223192387 0.00634278475638182 0.998604036974155 0.998076357089741 0.999016928650496 0.439393939393939 0.31736586376925 0.56703880329704 0.2 0.0771355120010656 0.385666510996607 0.13953488372093 0.0529765738668172 0.279324800314149 1.01316796815189 0.338592248441516 2.54554572760868 1 2276.5 4087 False False 0 0 0 0 0 0 0 3.17641849474646 1.88253057501686 5.31203563067686 0.000917852225791647 0.000336907707388146 0.00199669932151676 0.998604036974155 0.998076357089741 0.999016928650496 23 3) Uncertain significance No change no 1 +Ethambutol embA c.-8C>G embA_c.-8C>G 1 upstream_gene_variant 4243225 0 0 0 0 5 0 9476 35705 0.000527370530534753 0.000171257241502832 0.00123027414547083 1 0.999896689850119 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 3314 4975 False False Inf 3.45192218064103 Inf 0 0 0.000389210799037296 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2719 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 2 3) Uncertain significance No change no 1 +Ethambutol embA c.-8C>T embA_c.-8C>T 1 upstream_gene_variant 4243225 1 7 3 4 53 16 9428 35689 0.00559012762366839 0.00419011038284122 0.00730572445059807 0.999551883489707 0.999272388596077 0.99974384169233 0.768115942028985 0.650930519288853 0.861264823136231 0.428571428571428 0.0989882784425078 0.815948432359917 0.157894736842105 0.0338262490017646 0.395784551266674 2.83906979210861 0.415797062842764 16.7825978320789 0.163845104759845 158 4975 False False 12.5392249151463 7.05584132503068 23.5090450047898 0.000318099883363376 6.5604648087797e-05 0.0009293386420519 0.999551883489707 0.999272388596077 0.99974384169233 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 3 4 42 12 6518 26493 0.00640243902439024 0.00461809702932714 0.00864448621007096 0.999547255234861 0.999209279704825 0.999766038988972 0.777777777777777 0.644000905786651 0.879564217408901 0.428571428571428 0.0989882784425078 0.815948432359917 0.2 0.0433120051058366 0.480891133806853 3.04844277385701 0.446416290687068 18.0214398656368 0.14373442203722 115 4087 False False 0 0 0 0 0 0 0 14.2260662779993 7.34678817983193 29.6957010035691 0.000460052139242447 9.48838615080682e-05 0.00134387315785631 0.999547255234861 0.999209279704825 0.999766038988972 16 3) Uncertain significance No change no 1 +Ethambutol embA c.906G>A embA_c.906G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 15 4 9466 35701 0.00158211159160426 0.000885757734327454 0.00260811203671776 0.999887970872426 0.999713186009257 0.999969475016731 0.789473684210526 0.544346918108494 0.93947546229071 NA NA NA NA NA NA NA NA NA NA NA NA False False 14.1431174730614 4.50443362209023 58.564718155185 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 15 0 6545 26505 0.00228658536585365 0.0012803316536391 0.00376857487312357 1 0.999860832946126 1 1 0.781980639089466 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 14.5153519810754 Inf NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.909G>A embA_c.909G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.90C>T embA_c.90C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.912C>T embA_c.912C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.927G>A embA_c.927G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.951G>C embA_c.951G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 7 9481 35698 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.61285174975179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 7 6560 26498 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.80327602229365 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.975C>T embA_c.975C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.976C>T embA_c.976C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.987C>A embA_c.987C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.988C>T embA_c.988C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 24 399 9457 35306 0.00253137854656681 0.00162255461135746 0.00376416417214661 0.988825094524576 0.987680058471313 0.989889542983407 0.0567375886524822 0.0366874129634341 0.0832474065508301 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.224560555454407 0.142079772360169 0.339277651428528 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 23 371 6537 26134 0.00350609756097561 0.0022238236869373 0.00525625089693 0.98600264101113 0.984514935311658 0.98738234650996 0.0583756345177665 0.0373613176610764 0.0863071337301416 NA NA NA NA NA NA NA NA NA NA NA NA False True 1 1 1 0 0 0 1 0.247845665580995 0.155037499348955 0.37805211008422 NA NA NA NA NA NA 33 5) Not assoc w R Now listed Silent mutation no 0 +Ethambutol embA c.990G>C embA_c.990G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 1 9479 35704 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999971992718106 0.999843963402622 0.999999290917266 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 7.53328410169849 0.392120325718966 443.147628387906 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 2 1 6558 26504 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999962271269571 0.999789807096406 0.999999044791703 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 8.08295211954864 0.420719628662148 475.373667785977 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embA c.99G>T embA_c.99G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 43 9481 35662 0 0 0.00038900558066021 0.998795686878588 0.998378137129092 0.999128299767525 0 0 0.0822111211541385 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 0 0.337016458481183 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 0 39 6560 26466 0 0 0.000562171107654053 0.998528579513299 0.997989063008624 0.998953473433816 0 0 0.0902511009603342 NA NA NA NA NA NA NA NA NA NA NA NA False True 1 1 1 0 0 0 0 0 0 0.400367192477268 NA NA NA NA NA NA 4 5) Not assoc w R Now listed Silent mutation no 0 +Ethambutol embA LoF embA_LoF 1 LoF (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Ala1000Thr embA_p.Ala1000Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala1015Thr embA_p.Ala1015Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 19 9481 35686 0 0 0.00038900558066021 0.999467861644027 0.999169124220115 0.999679588507228 0 0 0.176466911806965 NA NA NA 0 0 0.176466911806965 NA NA NA NA 3409 4975 False False 0 0 0.80673399727041 0 0 0.00038900558066021 0.999467861644027 0.999169124220115 0.999679588507228 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 18 6560 26487 0 0 0.000562171107654053 0.999320882852292 0.998926913664084 0.999597464048431 0 0 0.185301968137852 NA NA NA 0 0 0.185301968137852 NA NA NA NA 2802 4087 False False 0 0 0 0 0 0 0 0 0 0.918654117939294 0 0 0.000562171107654053 0.999320882852292 0.998926913664084 0.999597464048431 5 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala1016Ser embA_p.Ala1016Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12104088004766 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala103Ser embA_p.Ala103Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3425 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2817 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala1069Val embA_p.Ala1069Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala1072Thr embA_p.Ala1072Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala109Thr embA_p.Ala109Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.11527461591697 1 2818.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.77947080093164 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala124Thr embA_p.Ala124Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3402 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2797 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Ala126Thr embA_p.Ala126Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Ala127Val embA_p.Ala127Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala133Thr embA_p.Ala133Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3491 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2878 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 1 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Ala148Glu embA_p.Ala148Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala150Thr embA_p.Ala150Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala159Pro embA_p.Ala159Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Ala159Ser embA_p.Ala159Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala187Val embA_p.Ala187Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Ala201Thr embA_p.Ala201Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 0 143 9481 35562 0 0 0.00038900558066021 0.995994958689259 0.995283801917621 0.996623454213809 0 0 0.0254664764133473 NA NA NA 0 0 0.0254664764133473 NA NA NA NA NA NA False True 0 0 0.0980572626057082 0 0 0.00038900558066021 0.995994958689259 0.995283801917621 0.996623454213809 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 0 136 6560 26369 0 0 0.000562171107654053 0.994868892661762 0.993933324998708 0.995693283825271 0 0 0.0267595583791432 NA NA NA 0 0 0.0267595583791432 NA NA NA NA NA NA False True 1 1 1 0 0 1 1 0 0 0.110566374346474 0 0 0.000562171107654053 0.994868892661762 0.993933324998708 0.995693283825271 5 Not assoc w R 5) Not assoc w R No change yes 1 +Ethambutol embA p.Ala205Thr embA_p.Ala205Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3382 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2777 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Ala217Thr embA_p.Ala217Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 5.70499352101301 0.585896604883905 379.5 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.77947080093164 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 1 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala223Val embA_p.Ala223Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala23Glu embA_p.Ala23Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3315 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala23Val embA_p.Ala23Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3375 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2770 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Ala249Thr embA_p.Ala249Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 3 3 9478 35702 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.99991597815432 0.999754472342108 0.99998267234027 0.5 0.118117248757025 0.881882751242974 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11841471655 1 2818.5 4975 False False 3.76682844481958 0.504418797674528 28.1425087484132 0 0 0.000389128685709026 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 2 3 6558 26502 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999886813808715 0.999669257903365 0.999976657677988 0.4 0.0527449505263169 0.853367200365326 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.78282164268659 1 2276.5 4087 False False 0 0 0 0 0 0 0 2.69411405916437 0.224966079471659 23.5225659748306 0 0 0.00056234250533983 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala255Thr embA_p.Ala255Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Ala259Ser embA_p.Ala259Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Ala259Thr embA_p.Ala259Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 2 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala291Thr embA_p.Ala291Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala302Thr embA_p.Ala302Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Ala312Val embA_p.Ala312Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 29 1 28 3 35 9478 35670 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999019745133734 0.998636963904226 0.999317124544511 0.0789473684210526 0.0165864758645295 0.213773291180618 0.0344827586206896 0.000872646883579922 0.177644295488722 0.0277777777777777 0.00070302520590478 0.145289264746853 0.134409007325234 0.00329048714165572 0.813217725903754 0.0196388185251187 63 4975 False False 0.322581617580562 0.0634679032309747 1.02363835778456 0.000105496360375567 2.67093302808208e-06 0.000587646375974446 0.999019745133734 0.998636963904226 0.999317124544511 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 24 0 24 2 29 6558 26476 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.998905866817581 0.998429017222443 0.999267123212173 0.064516129032258 0.0079109834618547 0.214216157163402 0 0 0.142473597722525 0 0 0.119444869069502 0 0 0.670995100248822 0.00847976422784082 39 4087 False False 0 0 0 0 0 0 0 0.278428032095571 0.0321820345249674 1.10110840479394 0 0 0.00056234250533983 0.998905866817581 0.998429017222443 0.999267123212173 9 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala315Pro embA_p.Ala315Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3276 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2687 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Ala316Gly embA_p.Ala316Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala316Pro embA_p.Ala316Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala320Thr embA_p.Ala320Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala320Val embA_p.Ala320Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2840 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Ala331Pro embA_p.Ala331Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala331Ser embA_p.Ala331Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala331Thr embA_p.Ala331Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 3 2 9478 35703 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999943985436213 0.999797670939776 0.99999321630447 0.6 0.146632799634673 0.947255049473683 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0657881638833 1 2818.5 4975 False False 5.65040092846592 0.647137685918782 67.7491623796885 0 0 0.000389128685709026 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2818 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 2 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala334Val embA_p.Ala334Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Ala355Ser embA_p.Ala355Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3439 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2835 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala355Val embA_p.Ala355Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala360Ser embA_p.Ala360Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3320 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2724 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala364Ser embA_p.Ala364Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3356 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala364Thr embA_p.Ala364Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala401Gly embA_p.Ala401Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3456 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala408Ser embA_p.Ala408Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 7 9481 35698 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 2.61285174975179 0.357638874560194 311 4975 False False 0 0 2.61285174975179 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 7 6560 26498 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 2.80327602229365 0.357905531825047 211.5 4087 False False 0 0 0 0 0 0 0 0 0 2.80327602229365 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala409Glu embA_p.Ala409Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 20.058335224773 1 1480 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 21.5165239024995 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala409Pro embA_p.Ala409Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 7 9481 35698 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 2.61285174975179 0.357638874560194 311 4975 False False 0 0 2.61285174975179 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12104088004766 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala409Thr embA_p.Ala409Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala415Val embA_p.Ala415Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala419Thr embA_p.Ala419Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala41Thr embA_p.Ala41Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Ala41Val embA_p.Ala41Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Ala430Thr embA_p.Ala430Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala436Gly embA_p.Ala436Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala436Val embA_p.Ala436Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Ala438Thr embA_p.Ala438Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala438Val embA_p.Ala438Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala440Thr embA_p.Ala440Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3321 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala448Gly embA_p.Ala448Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala454Thr embA_p.Ala454Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12104088004766 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Ala457Glu embA_p.Ala457Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Ala460Thr embA_p.Ala460Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 9.1150193618684 1 2818.5 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 9.77910191708565 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala461Pro embA_p.Ala461Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Ala461Thr embA_p.Ala461Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala477Gly embA_p.Ala477Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Ala477Thr embA_p.Ala477Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Ala483Thr embA_p.Ala483Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala494Ser embA_p.Ala494Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala520Thr embA_p.Ala520Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3386 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2781 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala545Pro embA_p.Ala545Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3330 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2730 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala549Pro embA_p.Ala549Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala557Thr embA_p.Ala557Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.11527461591697 1 2818.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala557Val embA_p.Ala557Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3346 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2747 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala571Thr embA_p.Ala571Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala576Thr embA_p.Ala576Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 37 6 9444 35699 0.00390254192595717 0.00274919326450094 0.00537516682549457 0.99983195630864 0.999634275787128 0.999938328510354 0.860465116279069 0.72067519968585 0.947023426133182 0 0 0.602364635616474 0 0 0.4592581264399 0 0 5.72718689872542 0.586156881926823 458 4975 False False 23.3104440208951 9.74806742104886 67.6900857567002 0 0 0.000390529341316127 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 37 6 6523 26499 0.00564024390243902 0.00397426947496204 0.0077660324341956 0.99977362761743 0.99950734823901 0.999916920939814 0.860465116279069 0.72067519968585 0.947023426133182 0 0 0.602364635616474 0 0 0.4592581264399 0 0 6.15530175612133 1 2276.5 4087 False False 0 0 0 0 0 0 0 25.0514333895446 10.4736321058366 72.7312997486049 0 0 0.000565358973674451 0.99977362761743 0.99950734823901 0.999916920939814 1 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala581Thr embA_p.Ala581Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala586Thr embA_p.Ala586Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala589Glu embA_p.Ala589Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala593Val embA_p.Ala593Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala60Asp embA_p.Ala60Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala661Pro embA_p.Ala661Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala662Thr embA_p.Ala662Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3449 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala66Val embA_p.Ala66Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala719Thr embA_p.Ala719Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala721Thr embA_p.Ala721Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala725Val embA_p.Ala725Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3406 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2800 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 1 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala734Thr embA_p.Ala734Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala734Val embA_p.Ala734Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 9478 35705 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 1 0.999896689850119 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3348 4975 False False Inf 1.55639137151076 Inf 0 0 0.000389128685709026 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 6557 26505 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 1 0.999860832946126 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2749 4087 False False 0 0 0 0 0 0 0 Inf 1.66990152933523 Inf 0 0 0.000562428243381166 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala736Val embA_p.Ala736Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala757Ser embA_p.Ala757Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3304 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2712 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Ala797Pro embA_p.Ala797Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3277 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Ala80Thr embA_p.Ala80Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3395 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala813Gly embA_p.Ala813Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 72 55 9409 35650 0.00759413563970045 0.00594655009658673 0.00955412857161153 0.998459599495868 0.997995422923695 0.99883935521482 0.566929133858267 0.47611568734306 0.654549226874374 NA NA NA 0 0 0.0648707608254246 NA NA NA NA NA NA False True 4.96004792316833 3.4407186019537 7.18424003430267 0 0 0.000391981764282433 0.998459599495868 0.997995422923695 0.99883935521482 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 43 47 6517 26458 0.00655487804878048 0.00474774076305732 0.00881932836735044 0.998226749669873 0.997642642624476 0.99869680036167 0.477777777777777 0.371326664997805 0.585732110268341 NA NA NA 0 0 0.0754857336910586 NA NA NA NA NA NA False True 0 0 1 0 0 1 1 3.71432489169079 2.39556131179999 5.74513734105994 0 0 0.000565879334866127 0.998226749669873 0.997642642624476 0.99869680036167 65 Not assoc w RI Literature evidence (PMID 32143680) 4) Not assoc w R - Interim No change yes Lit. (PMID 32143680) 1 +Ethambutol embA p.Ala826Glu embA_p.Ala826Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Ala835Glu embA_p.Ala835Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.058895521352 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 21.5173342675905 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 1 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala835Pro embA_p.Ala835Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3331 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2731 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala835Thr embA_p.Ala835Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3492 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala849Pro embA_p.Ala849Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala84Ser embA_p.Ala84Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 0 9 0 11 9481 35694 0 0 0.00038900558066021 0.999691919899173 0.999448826618347 0.999846197812 0 0 0.284914152918154 0 0 0.336267116879942 0 0 0.284914152918154 0 0 1.90775632399327 0.219223612419558 252.5 4975 False False 0 0 1.50034693324555 0 0 0.00038900558066021 0.999691919899173 0.999448826618347 0.999846197812 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala850del embA_p.Ala850del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala852Thr embA_p.Ala852Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 18 0 18 0 18 9481 35687 0 0 0.00038900558066021 0.99949586892592 0.999203372130377 0.999701193476901 0 0 0.185301968137852 0 0 0.185301968137852 0 0 0.185301968137852 0 0 0.856331153965207 0.0203524264802286 64 4975 False False 0 0 0.856331153965207 0 0 0.00038900558066021 0.99949586892592 0.999203372130377 0.999701193476901 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 18 0 18 0 18 6560 26487 0 0 0.000562171107654053 0.999320882852292 0.998926913664084 0.999597464048431 0 0 0.185301968137852 0 0 0.185301968137852 0 0 0.185301968137852 0 0 0.918654117939294 0.0341511965954247 61 4087 False False 0 0 0 0 0 0 0 0 0 0.918654117939294 0 0 0.000562171107654053 0.999320882852292 0.998926913664084 0.999597464048431 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala852Val embA_p.Ala852Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3493 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2879 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala874Thr embA_p.Ala874Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Ala874Val embA_p.Ala874Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3434 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2830 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Ala921Ser embA_p.Ala921Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala930Val embA_p.Ala930Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala936Val embA_p.Ala936Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala955Thr embA_p.Ala955Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3450 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala95Thr embA_p.Ala95Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala974Thr embA_p.Ala974Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala984Thr embA_p.Ala984Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ala985Pro embA_p.Ala985Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Arg1047Gly embA_p.Arg1047Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Arg1052Gly embA_p.Arg1052Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3483 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2870 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Arg1062Leu embA_p.Arg1062Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3367 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2762 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Arg108Ser embA_p.Arg108Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Arg11Gln embA_p.Arg11Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 4 9480 35701 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999887970872426 0.999713186009257 0.999969475016731 0.2 0.00505076337946806 0.716417936118089 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.11623600185219 1 1480 4975 False False 0.941482067510548 0.0191153149568561 9.51304376083015 0 0 0.00038904660702099 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 4 6559 26501 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999849085078287 0.999613643356053 0.999958879281354 0.2 0.00505076337946806 0.716417936118089 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.780961496544 1 2276.5 4087 False False 0 0 0 0 0 0 0 1.01010062509528 0.0205075656450505 10.2127021503241 0 0 0.000562256793434776 0.999849085078287 0.999613643356053 0.999958879281354 2 3) Uncertain significance No change no 1 +Ethambutol embA p.Arg11Trp embA_p.Arg11Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 9479 35704 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999971992718106 0.999843963402622 0.999999290917266 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 146.569015564619 1 2818.5 4975 False False 7.53328410169849 0.392120325718966 443.147628387906 0 0 0.000389087642036349 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2845 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Arg188His embA_p.Arg188His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Arg194Gln embA_p.Arg194Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 8 9481 35697 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 0 0 0.369416647552819 0 0 0.409616397225003 0 0 0.369416647552819 0 0 2.61277856511022 0.357639330631355 317 4975 False False 0 0 2.20624116275339 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 7 6560 26498 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 3.43152889101174 0.605984763142217 320.5 4087 False False 0 0 0 0 0 0 0 0 0 2.80327602229365 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Arg229Lys embA_p.Arg229Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Arg229Ser embA_p.Arg229Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 157.21479794295 1 1103 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Arg229Thr embA_p.Arg229Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Arg234His embA_p.Arg234His 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Arg234Pro embA_p.Arg234Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Arg239Gln embA_p.Arg239Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 3.76624472573839 0.0479745002090283 294.932792118969 0.375621806809355 335.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 4.04085988717792 0.0514701624188962 316.380494544091 0.35743759524028 195 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Arg241His embA_p.Arg241His 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3357 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2752 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Arg243Trp embA_p.Arg243Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Arg245Trp embA_p.Arg245Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethambutol embA p.Arg251Gln embA_p.Arg251Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3349 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2750 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Arg251Leu embA_p.Arg251Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Arg282Trp embA_p.Arg282Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Arg325Cys embA_p.Arg325Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Arg345Pro embA_p.Arg345Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Arg346Gln embA_p.Arg346Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Arg346Pro embA_p.Arg346Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Arg346Trp embA_p.Arg346Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Arg358Gln embA_p.Arg358Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Arg358Leu embA_p.Arg358Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Arg380Leu embA_p.Arg380Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0615661524565 1 2818.5 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Arg404Gln embA_p.Arg404Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 8 9481 35697 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 3285 4975 False False 0 0 2.20624116275339 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2695 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Arg442Lys embA_p.Arg442Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Arg444Trp embA_p.Arg444Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Arg445Pro embA_p.Arg445Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embA p.Arg446His embA_p.Arg446His 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3294 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2703 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Arg447Gly embA_p.Arg447Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Arg447Pro embA_p.Arg447Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Arg472Leu embA_p.Arg472Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3332 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2732 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Arg517Cys embA_p.Arg517Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3295 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2704 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Arg538His embA_p.Arg538His 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3305 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2713 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embA p.Arg594His embA_p.Arg594His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Arg600_Arg601insLeuGlyLeuHisSerArg embA_p.Arg600_Arg601insLeuGlyLeuHisSerArg 1 inframe_insertion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Arg680Trp embA_p.Arg680Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3470 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2861 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Arg683_Ala686del embA_p.Arg683_Ala686del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Arg68His embA_p.Arg68His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Arg68Pro embA_p.Arg68Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 9480 35702 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99991597815432 0.999754472342108 0.99998267234027 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11649128277037 1 2818.5 4975 False False 1.25534458509142 0.0239099774609589 15.6346568618898 0 0 0.00038904660702099 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 2 3) Uncertain significance No change no 1 +Ethambutol embA p.Arg836Cys embA_p.Arg836Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3278 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2688 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Arg836Gly embA_p.Arg836Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2733 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Arg866Gln embA_p.Arg866Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Arg866Leu embA_p.Arg866Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Arg904His embA_p.Arg904His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Arg940Ser embA_p.Arg940Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Arg969Trp embA_p.Arg969Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Arg991Gln embA_p.Arg991Gln 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3410 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2803 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Asn1019Asp embA_p.Asn1019Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3296 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2705 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Asn110Asp embA_p.Asn110Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3451 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2846 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Asn376Asp embA_p.Asn376Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3457 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Asn377Gly embA_p.Asn377Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Asn510Ser embA_p.Asn510Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3407 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2801 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Asn510Thr embA_p.Asn510Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Asn54Asp embA_p.Asn54Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 82 5 9399 35700 0.00864887670076996 0.00688444977411114 0.0107243200644554 0.999859963590533 0.999673232250017 0.999954529045718 0.942528735632184 0.870957543712074 0.98107810983103 0 0 0.707598226178713 0 0 0.521823750104981 0 0 9.19452964217906 1 2818.5 4975 False False 62.2917331631024 25.6170900905146 197.05446407951 0 0 0.000392398728691043 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 16 0 6544 26505 0.0024390243902439 0.00139473586445882 0.00395780883041526 1 0.999860832946126 1 1 0.794092785792177 1 NA NA NA NA NA NA NA NA NA NA 2871 4087 False False 0 0 0 0 0 0 0 Inf 15.6166029346637 Inf 0 0 0.000563545221770202 1 0.999860832946126 1 10 3) Uncertain significance No change no 1 +Ethambutol embA p.Asn54Ser embA_p.Asn54Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3452 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2847 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Asn629Ser embA_p.Asn629Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3358 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2753 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Asn629Tyr embA_p.Asn629Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Asn722Asp embA_p.Asn722Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 2 1 9479 35704 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999971992718106 0.999843963402622 0.999999290917266 0.666666666666666 0.0942993240502461 0.991596241340387 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 3.76664205084924 0.0479795608259237 294.963825413313 0.375594169672617 330 4975 False False 7.53328410169849 0.392120325718966 443.147628387906 0.00010548523206751 2.670651284468e-06 0.000587584402906152 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 2 1 6558 26504 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999962271269571 0.999789807096406 0.999999044791703 0.666666666666666 0.0942993240502461 0.991596241340387 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 4.04147605977432 0.0514780097003315 316.428602536846 0.357398726268635 188 4087 False False 0 0 0 0 0 0 0 8.08295211954864 0.420719628662148 475.373667785977 0.000152462265589266 3.86000291520843e-06 0.000849169393567967 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Asn803Lys embA_p.Asn803Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3458 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Asn847Ser embA_p.Asn847Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Asn85Tyr embA_p.Asn85Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3453 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2848 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Asn947Ser embA_p.Asn947Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3417 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2809 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Asn986Lys embA_p.Asn986Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Asp1049Ala embA_p.Asp1049Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Asp1053Asn embA_p.Asp1053Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3418 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 2810 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Asp1053Gly embA_p.Asp1053Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Asp1071Glu embA_p.Asp1071Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3359 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2754 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Asp112Gly embA_p.Asp112Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 1 5 1 5 9480 35700 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999859963590533 0.999673232250017 0.999954529045718 0.166666666666666 0.00421074451448947 0.641234578997674 0.166666666666666 0.00421074451448947 0.641234578997674 0.166666666666666 0.00421074451448947 0.641234578997674 0.753164556962025 0.0159260191955521 6.73154939272228 1 2818.5 4975 False False 0.753164556962025 0.0159260191955521 6.73154939272228 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 3 3) Uncertain significance No change no 1 +Ethambutol embA p.Asp120Asn embA_p.Asp120Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 0 9477 35705 0.000421896424427802 0.000114964157806894 0.00107986688593449 1 0.999896689850119 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3360 4975 False False Inf 2.4863933079676 Inf 0 0 0.000389169738041761 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2755 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Asp144Gly embA_p.Asp144Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Asp176Ala embA_p.Asp176Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Asp176Glu embA_p.Asp176Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 31 1 30 2 38 9479 35667 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.998935723288054 0.998539486720009 0.99924674779982 0.05 0.00611364659935083 0.169196863959417 0.032258064516129 0.000816370071846613 0.167021116230227 0.0256410256410256 0.000648963895481945 0.134763921559497 0.125424622850511 0.00307780026123069 0.754693235405085 0.0129286998737726 60 4975 False False 0.198038878185018 0.0231591448017876 0.766559502535627 0.00010548523206751 2.670651284468e-06 0.000587584402906152 0.998935723288054 0.998539486720009 0.99924674779982 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 1 5 2 7 6558 26498 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999735898887002 0.999455926960675 0.999893811273379 0.222222222222222 0.0281449734778982 0.600093573716312 0.166666666666666 0.00421074451448947 0.641234578997674 0.125 0.0031597235312519 0.526509670875206 0.808112229338212 0.0170830769151481 7.22365718882604 1 2276.5 4087 False False 0 0 0 0 0 0 0 1.15444604191173 0.116966185780849 6.06524023731598 0.000152462265589266 3.86000291520843e-06 0.000849169393567967 0.999735898887002 0.999455926960675 0.999893811273379 2 3) Uncertain significance No change no 1 +Ethambutol embA p.Asp176His embA_p.Asp176His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3477 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2866 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Asp235Ala embA_p.Asp235Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Asp235Asn embA_p.Asp235Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Asp235Gly embA_p.Asp235Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3297 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2706 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Asp273Gly embA_p.Asp273Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embA p.Asp274Gly embA_p.Asp274Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3306 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2714 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Asp305Gly embA_p.Asp305Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Asp473Gly embA_p.Asp473Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Asp498Gly embA_p.Asp498Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3484 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2872 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Asp4Asn embA_p.Asp4Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 3 9480 35702 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99991597815432 0.999754472342108 0.99998267234027 0.25 0.00630946320970987 0.805879550316756 0 0 0.975 0 0 0.707598226178713 0 0 146.545399763461 1 2818.5 4975 False False 1.25534458509142 0.0239099774609589 15.6346568618898 0 0 0.00038904660702099 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 3 6559 26502 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999886813808715 0.999669257903365 0.999976657677988 0.25 0.00630946320970987 0.805879550316756 0 0 0.975 0 0 0.707598226178713 0 0 157.202964052604 1 2276.5 4087 False False 0 0 0 0 0 0 0 1.34685165421558 0.025651688752077 16.7753654027497 0 0 0.000562256793434776 0.999886813808715 0.999669257903365 0.999976657677988 1 3) Uncertain significance No change no 1 +Ethambutol embA p.Asp4Tyr embA_p.Asp4Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2742 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Asp52Asn embA_p.Asp52Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3376 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2771 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Asp52His embA_p.Asp52His 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3419 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2811 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Asp636Asn embA_p.Asp636Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3426 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2819 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Asp669Glu embA_p.Asp669Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3347 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Asp678Asn embA_p.Asp678Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Asp678Gly embA_p.Asp678Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3429 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2822 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Asp737Glu embA_p.Asp737Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Asp737Gly embA_p.Asp737Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3286 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2696 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Asp738dup embA_p.Asp738dup 1 inframe_insertion (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3387 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2782 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Asp744Ala embA_p.Asp744Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3478 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2867 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Asp761Asn embA_p.Asp761Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3420 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2812 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Asp784Asn embA_p.Asp784Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Asp808Ala embA_p.Asp808Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.707313928675496 Inf 0.0440214455254381 88.5 4975 False False Inf 0.707313928675496 Inf 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Asp865Asn embA_p.Asp865Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 13 0 13 6 20 9475 35685 0.000632844636641704 0.000232277107744303 0.00137692358870305 0.999439854362134 0.999135032404509 0.999657815983264 0.23076923076923 0.0897401108845751 0.436475096941386 0 0 0.24705263800047 0 0 0.168433470983085 0 0 1.23603640916724 0.0841502502376861 119 4975 False False 1.12986807387862 0.371165166523324 2.91794768777923 0 0 0.000389251868698371 0.999439854362134 0.999135032404509 0.999657815983264 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 12 0 12 6 18 6554 26487 0.000914634146341463 0.000335726224038477 0.00198970246660848 0.999320882852292 0.998926913664084 0.999597464048431 0.25 0.097730409474533 0.467112802422669 0 0 0.264648469397051 0 0 0.185301968137852 0 0 1.45486741211073 0.14073688945451 108 4087 False False 0 0 0 0 0 0 0 1.34711626487641 0.437548022263255 3.5442522591884 0 0 0.000562685614442453 0.999320882852292 0.998926913664084 0.999597464048431 1 3) Uncertain significance No change no 1 +Ethambutol embA p.Asp865Glu embA_p.Asp865Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embA p.Asp865Val embA_p.Asp865Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Asp883Glu embA_p.Asp883Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Asp902Glu embA_p.Asp902Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Cys28Tyr embA_p.Cys28Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Cys335Trp embA_p.Cys335Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 0 0 0.602364635616474 0 0 0.4592581264399 0 0 5.70483372250837 0.585894740941386 369 4975 False False 0 0 3.19822685561766 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 6 6560 26499 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 0 0 0.4592581264399 0 0 0.602364635616474 0 0 0.4592581264399 0 0 6.12057895719864 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 3.43165838346939 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 1 3) Uncertain significance No change no 1 +Ethambutol embA p.Cys527Tyr embA_p.Cys527Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3341 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2743 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Cys76Phe embA_p.Cys76Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Gln1004Arg embA_p.Gln1004Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Gln1004Pro embA_p.Gln1004Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 29 0 29 1 32 9480 35673 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999103766979414 0.998735019826828 0.999386899029865 0.0303030303030303 0.000766912075048109 0.157593972272496 0 0 0.119444869069502 0 0 0.108881160679352 0 0 0.510564951677782 0.00205070450935144 34 4975 False False 0.117592958860759 0.00289163333140947 0.704166558527466 0 0 0.00038904660702099 0.999103766979414 0.998735019826828 0.999386899029865 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 20 0 20 1 22 6559 26483 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999169967930579 0.998743589564863 0.99947975252246 0.0434782608695652 0.0011001686304415 0.21948660745348 0 0 0.168433470983085 0 0 0.154372512815574 0 0 0.818106193906268 0.0214225093396936 48 4087 False False 0 0 0 0 0 0 0 0.18352991725457 0.00444997863868461 1.13588001498513 0 0 0.000562256793434776 0.999169967930579 0.998743589564863 0.99947975252246 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Gln1059Pro embA_p.Gln1059Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Gln169Glu embA_p.Gln169Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 0 8 9481 35697 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 2.20624116275339 0.217681019156043 228.5 4975 False False 0 0 2.20624116275339 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 6560 26499 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.43165838346939 0.605981932438924 311.5 4087 False False 0 0 0 0 0 0 0 0 0 3.43165838346939 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Gln169Pro embA_p.Gln169Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Gln47His embA_p.Gln47His 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.841886116991581 0 0 0.521823750104981 0 0 20.0577749283512 1 2818.5 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2851 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Gln497Arg embA_p.Gln497Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3388 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2783 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 3 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Gln497His embA_p.Gln497His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.096562813829025 Inf 0.209821626167397 198.5 4975 False False Inf 0.096562813829025 Inf 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.103599830448027 Inf 0.198397096627854 142 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Gln57Arg embA_p.Gln57Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Gln57Glu embA_p.Gln57Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Gln751Pro embA_p.Gln751Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Gln858Arg embA_p.Gln858Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0615661524565 1 2818.5 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.5214194708504 1 2276.5 4087 False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 0 0 0.000562256793434776 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Gln990His embA_p.Gln990His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Glu1075Asp embA_p.Glu1075Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3307 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2715 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Glu1075Val embA_p.Glu1075Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Glu301Ala embA_p.Glu301Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 157.21479794295 1 1103 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Glu397Lys embA_p.Glu397Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Glu481Gln embA_p.Glu481Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3322 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Glu508Ala embA_p.Glu508Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Glu508Asp embA_p.Glu508Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Glu508Lys embA_p.Glu508Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Glu512Ala embA_p.Glu512Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3445 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2841 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Glu675Lys embA_p.Glu675Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3308 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Glu742Asp embA_p.Glu742Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Glu779Gln embA_p.Glu779Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.058895521352 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2778 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Glu7Lys embA_p.Glu7Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 9480 35702 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99991597815432 0.999754472342108 0.99998267234027 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11649128277037 1 2818.5 4975 False False 1.25534458509142 0.0239099774609589 15.6346568618898 0 0 0.00038904660702099 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.5214194708504 1 2276.5 4087 False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 0 0 0.000562256793434776 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Glu882Lys embA_p.Glu882Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3383 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Glu951Asp embA_p.Glu951Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 172 2 170 34 206 9447 35499 0.00358611960763632 0.00248473185647407 0.00500767053673668 0.994230499929981 0.993389326522686 0.99498967456023 0.141666666666666 0.100144850275307 0.192300685032121 0.0116279069767441 0.00141130865300443 0.0413708531360421 0.00961538461538461 0.00116659629081665 0.0343005627203956 0.0442082453813535 0.00532303316508011 0.162239670232425 4.21907696313524e-15 NA NA False True 0.620203054136464 0.417895181311204 0.895393203307612 0.000211662609799978 2.56343519562118e-05 0.000764386765841687 0.994230499929981 0.993389326522686 0.99498967456023 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 112 2 110 15 125 6545 26380 0.00228658536585365 0.0012803316536391 0.00376857487312357 0.995283908696472 0.994383529020684 0.996072887503636 0.107142857142857 0.0612199489262987 0.170553591220863 0.0178571428571428 0.00216994638493558 0.0630189471879673 0.0157480314960629 0.00191288212279393 0.0557290866940918 0.0732828668657545 0.00875503001770851 0.271242050992557 1.42790005399336e-08 NA NA False True 0 1 1 0 0 1 1 0.48366692131398 0.262662501393478 0.829491827901849 0.000305483427524056 3.69976015731486e-05 0.00110307094727248 0.995283908696472 0.994383529020684 0.996072887503636 9 Not assoc w RI 5) Not assoc w R UP from NotAwRI to NotAwR yes 4 +Ethambutol embA p.Glu951Lys embA_p.Glu951Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Glu995Gly embA_p.Glu995Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Gly101Ser embA_p.Gly101Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly1048Arg embA_p.Gly1048Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Gly1048Trp embA_p.Gly1048Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3316 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2720 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly1077Ser embA_p.Gly1077Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly1083Asp embA_p.Gly1083Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly1085Ser embA_p.Gly1085Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly1085Val embA_p.Gly1085Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly1088* embA_p.Gly1088* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly134Arg embA_p.Gly134Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 3.76624472573839 0.0479745002090283 294.932792118969 0.375621806809355 335.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 4.04085988717792 0.0514701624188962 316.380494544091 0.35743759524028 195 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Gly135Asp embA_p.Gly135Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3396 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2792 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly149Asp embA_p.Gly149Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3323 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Gly149Ser embA_p.Gly149Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Gly154Arg embA_p.Gly154Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly154Ser embA_p.Gly154Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 21 9481 35684 0 0 0.00038900558066021 0.99941184708024 0.99910108554872 0.999635888372764 0 0 0.161097615219079 0 0 0.975 0 0 0.161097615219079 0 0 146.456273006435 1 2818.5 4975 False False 0 0 0.722928583272661 0 0 0.00038900558066021 0.99941184708024 0.99910108554872 0.999635888372764 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 20 6560 26485 0 0 0.000562171107654053 0.999245425391435 0.998834860097994 0.999539027227828 0 0 0.168433470983085 0 0 0.975 0 0 0.168433470983085 0 0 157.078486052749 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 0.818043220340071 0 0 0.000562171107654053 0.999245425391435 0.998834860097994 0.999539027227828 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly158Asp embA_p.Gly158Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 12 0 12 0 12 9481 35693 0 0 0.00038900558066021 0.99966391261728 0.999412996653316 0.999826327071809 0 0 0.264648469397051 0 0 0.264648469397051 0 0 0.264648469397051 0 0 1.35519147325258 0.0835905265175333 111 4975 False False 0 0 1.35519147325258 0 0 0.00038900558066021 0.99966391261728 0.999412996653316 0.999826327071809 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 12 0 12 0 12 6560 26493 0 0 0.000562171107654053 0.999547255234861 0.999209279704825 0.999766038988972 0 0 0.264648469397051 0 0 0.264648469397051 0 0 0.264648469397051 0 0 1.45386850159099 0.140764243939364 113 4087 False False 0 0 0 0 0 0 0 0 0 1.45386850159099 0 0 0.000562171107654053 0.999547255234861 0.999209279704825 0.999766038988972 1 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly180Arg embA_p.Gly180Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly180Glu embA_p.Gly180Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3324 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2725 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Gly200Ala embA_p.Gly200Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Gly200Ser embA_p.Gly200Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly210Ser embA_p.Gly210Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3389 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2784 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly210Val embA_p.Gly210Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly21Arg embA_p.Gly21Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly220Glu embA_p.Gly220Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 9.1150193618684 1 2818.5 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2823 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Gly220Met embA_p.Gly220Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3421 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2813 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Gly230Ser embA_p.Gly230Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly247Ala embA_p.Gly247Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Gly275Ser embA_p.Gly275Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly288Ser embA_p.Gly288Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3289 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2699 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Gly298Asp embA_p.Gly298Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3317 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2721 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly29Ser embA_p.Gly29Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly29Val embA_p.Gly29Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3471 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly321Ala embA_p.Gly321Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly332Glu embA_p.Gly332Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.11527461591697 1 2818.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 21.5173342675905 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 2 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly348Ala embA_p.Gly348Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3485 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2873 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly348Glu embA_p.Gly348Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3435 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2831 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly350Ala embA_p.Gly350Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly352Ser embA_p.Gly352Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 0 0 0.602364635616474 0 0 0.4592581264399 0 0 5.70483372250837 0.585894740941386 369 4975 False False 0 0 3.19822685561766 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.77947080093164 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly353Arg embA_p.Gly353Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.058895521352 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly353Glu embA_p.Gly353Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3430 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2824 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Gly365Asp embA_p.Gly365Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Gly378Ser embA_p.Gly378Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3333 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2734 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly388Ser embA_p.Gly388Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3384 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2779 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Gly403Ala embA_p.Gly403Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Gly403Arg embA_p.Gly403Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3472 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2862 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Gly435Asp embA_p.Gly435Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Gly451Arg embA_p.Gly451Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 13 0 13 0 14 9481 35691 0 0 0.00038900558066021 0.999607898053494 0.999342206985133 0.999785618166341 0 0 0.231635761650116 0 0 0.24705263800047 0 0 0.231635761650116 0 0 1.23546164182752 0.0841529050803193 122 4975 False False 0 0 1.13511057396106 0 0 0.00038900558066021 0.999607898053494 0.999342206985133 0.999785618166341 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 13 0 13 0 14 6560 26491 0 0 0.000562171107654053 0.999471797774004 0.999113925067086 0.999711197799087 0 0 0.231635761650116 0 0 0.24705263800047 0 0 0.231635761650116 0 0 1.32543811097122 0.0853059820334418 82.5 4087 False False 0 0 0 0 0 0 0 0 0 1.21779664057642 0 0 0.000562171107654053 0.999471797774004 0.999113925067086 0.999711197799087 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly530Glu embA_p.Gly530Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly543Ala embA_p.Gly543Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3436 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2832 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Gly547Arg embA_p.Gly547Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly547Asp embA_p.Gly547Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly547Ser embA_p.Gly547Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.10982832991351 0.590980565810755 492 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12104088004766 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly596Asp embA_p.Gly596Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12104088004766 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly596Ser embA_p.Gly596Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 0 9 1 13 9480 35692 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999635905335387 0.999377467513205 0.999806121137399 0.0714285714285714 0.00180678065912538 0.338684489931821 0 0 0.336267116879942 0 0 0.24705263800047 0 0 1.9078506973416 0.219223063580538 247 4975 False False 0.28961376176566 0.00681762323326769 1.92866803203756 0 0 0.00038904660702099 0.999635905335387 0.999377467513205 0.999806121137399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 1 12 6559 26493 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999547255234861 0.999209279704825 0.999766038988972 0.0769230769230769 0.00194562849734675 0.360297435267877 0 0 0.336267116879942 0 0 0.264648469397051 0 0 2.04699138831578 0.220133115708722 169 4087 False False 0 0 0 0 0 0 0 0.336598566854703 0.00787634621975887 2.27570833059465 0 0 0.000562256793434776 0.999547255234861 0.999209279704825 0.999766038988972 3 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly5Arg embA_p.Gly5Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 5 4 9476 35701 0.000527370530534753 0.000171257241502832 0.00123027414547083 0.999887970872426 0.999713186009257 0.999969475016731 0.555555555555555 0.212008506778868 0.863004337734833 0 0 0.975 0 0 0.602364635616474 0 0 146.603020771832 1 2818.5 4975 False False 4.70939742507387 1.01338649657011 23.7370889289433 0 0 0.000389210799037296 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 5 1 6555 26504 0.000762195121951219 0.000247527523788107 0.00177780526826415 0.999962271269571 0.999789807096406 0.999999044791703 0.833333333333333 0.358765421002325 0.99578925548551 NA NA NA 0 0 0.975 NA NA NA NA 2825 4087 False False 0 0 0 0 0 0 0 20.2166285278413 2.26137738039683 951.169010205643 0 0 0.00056259979792051 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly5Ser embA_p.Gly5Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 8 8 9473 35697 0.000843792848855605 0.000364358012393849 0.00166192766222289 0.999775941744853 0.999558563909973 0.999903262744512 0.5 0.246510111490575 0.753489888509424 0 0 0.975 0 0 0.369416647552819 0 0 146.632949296673 1 1480 4975 False False 3.76828882085928 1.23241064892294 11.5210720406586 0 0 0.000389334034028122 0.999775941744853 0.999558563909973 0.999903262744512 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 7 4 6553 26501 0.0010670731707317 0.000429122972600259 0.00219733487653492 0.999849085078287 0.999613643356053 0.999958879281354 0.636363636363636 0.307904715011677 0.890736556180901 0 0 0.975 0 0 0.602364635616474 0 0 157.34062463039 1 2276.5 4087 False False 0 0 0 0 0 0 0 7.07717839157637 1.7983262297981 32.9530091243419 0 0 0.000562771457148547 0.999849085078287 0.999613643356053 0.999958879281354 2 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly5Val embA_p.Gly5Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 5 10 9476 35695 0.000527370530534753 0.000171257241502832 0.00123027414547083 0.999719927181067 0.999484996631079 0.999865686288203 0.333333333333333 0.11824110336688 0.616196267458845 NA NA NA 0 0 0.30849710781876 NA NA NA NA 3325 4975 False False 1.88344238075137 0.504985540682869 6.04942610952387 0 0 0.000389210799037296 0.999719927181067 0.999484996631079 0.999865686288203 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 4 6557 26501 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 0.999849085078287 0.999613643356053 0.999958879281354 0.428571428571428 0.0989882784425078 0.815948432359917 NA NA NA 0 0 0.602364635616474 NA NA NA NA 2726 4087 False False 0 0 0 0 0 0 0 3.0312261705048 0.443920296646785 17.9196364560967 0 0 0.000562428243381166 0.999849085078287 0.999613643356053 0.999958879281354 1 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly623Ala embA_p.Gly623Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Gly628Asp embA_p.Gly628Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3459 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2852 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Gly658Glu embA_p.Gly658Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Gly700Cys embA_p.Gly700Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Gly729Arg embA_p.Gly729Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 13 4 9468 35701 0.00137116337939035 0.000730282374626527 0.00234358976784705 0.999887970872426 0.999713186009257 0.999969475016731 0.764705882352941 0.501006726795419 0.931892259562643 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.12778846111928 1 1480 4975 False False 12.2547792564427 3.78449137073913 51.6260562525044 0 0 0.000389539599191658 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 6 3 6554 26502 0.000914634146341463 0.000335726224038477 0.00198970246660848 0.999886813808715 0.999669257903365 0.999976657677988 0.666666666666666 0.29929505620854 0.925145368580308 0 0 0.841886116991581 0 0 0.707598226178713 0 0 21.5369976097129 1 2276.5 4087 False False 0 0 0 0 0 0 0 8.08727494659749 1.7264855065906 50.0074859620969 0 0 0.000562685614442453 0.999886813808715 0.999669257903365 0.999976657677988 16 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly748Ser embA_p.Gly748Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly759Arg embA_p.Gly759Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 1 9478 35704 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999971992718106 0.999843963402622 0.999999290917266 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 3460 4975 False False 11.3011183794049 0.90722384791697 591.183089908516 0 0 0.000389128685709026 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 1 6558 26504 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999962271269571 0.999789807096406 0.999999044791703 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 2853 4087 False False 0 0 0 0 0 0 0 8.08295211954864 0.420719628662148 475.373667785977 0 0 0.00056234250533983 0.999962271269571 0.999789807096406 0.999999044791703 5 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly765Asp embA_p.Gly765Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3342 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly771Asp embA_p.Gly771Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly778Ser embA_p.Gly778Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3309 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly815Glu embA_p.Gly815Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3461 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2854 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Gly817Ser embA_p.Gly817Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly823Arg embA_p.Gly823Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly823Glu embA_p.Gly823Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly841Ala embA_p.Gly841Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3427 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2820 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly844Arg embA_p.Gly844Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3403 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2798 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly86Ala embA_p.Gly86Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3422 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2814 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Gly86Val embA_p.Gly86Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.10982832991351 0.590980565810755 492 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly884Asp embA_p.Gly884Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 11 0 11 0 15 9481 35690 0 0 0.00038900558066021 0.9995798907716 0.999307188228015 0.999764849596654 0 0 0.218019360910534 0 0 0.284914152918154 0 0 0.218019360910534 0 0 1.50017878745639 0.1354555121843 156 4975 False False 0 0 1.04976500705909 0 0 0.00038900558066021 0.9995798907716 0.999307188228015 0.999764849596654 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 0 11 0 15 6560 26490 0 0 0.000562171107654053 0.999434069043576 0.999066754461952 0.999683219243554 0 0 0.218019360910534 0 0 0.284914152918154 0 0 0.218019360910534 0 0 1.60941387230091 0.13661248188217 100 4087 False False 0 0 0 0 0 0 0 0 0 1.12620234951212 0 0 0.000562171107654053 0.999434069043576 0.999066754461952 0.999683219243554 1 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly909Arg embA_p.Gly909Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Gly909Glu embA_p.Gly909Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly96Asp embA_p.Gly96Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3298 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2707 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly972Arg embA_p.Gly972Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Gly972Trp embA_p.Gly972Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.His1061Gln embA_p.His1061Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.His10Asn embA_p.His10Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.His140Asp embA_p.His140Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.His598Arg embA_p.His598Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 9478 35705 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 1 0.999896689850119 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3390 4975 False False Inf 1.55639137151076 Inf 0 0 0.000389128685709026 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2785 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.His598Tyr embA_p.His598Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 0 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 157.21479794295 1 1103 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.His665Tyr embA_p.His665Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.His673Arg embA_p.His673Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.10982832991351 0.590980565810755 492 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.40943166615857 0.590385352956204 278 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.His825Tyr embA_p.His825Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3361 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2756 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ile1007Leu embA_p.Ile1007Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ile1007Val embA_p.Ile1007Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ile12Thr embA_p.Ile12Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Ile131Val embA_p.Ile131Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ile141Thr embA_p.Ile141Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ile155Met embA_p.Ile155Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 2 11 9479 35694 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999691919899173 0.999448826618347 0.999846197812 0.153846153846153 0.0192066719825284 0.454471055676557 0 0 0.841886116991581 0 0 0.284914152918154 0 0 20.0586331947006 1 2818.5 4975 False False 0.684652197680998 0.0737281243774716 3.13779303174923 0 0 0.000389087642036349 0.999691919899173 0.999448826618347 0.999846197812 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 3 6559 26502 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999886813808715 0.999669257903365 0.999976657677988 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 21.5206089807014 1 2276.5 4087 False False 0 0 0 0 0 0 0 1.34685165421558 0.025651688752077 16.7753654027497 0 0 0.000562256793434776 0.999886813808715 0.999669257903365 0.999976657677988 1 3) Uncertain significance No change no 1 +Ethambutol embA p.Ile155Val embA_p.Ile155Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 0 9 0 10 9481 35695 0 0 0.00038900558066021 0.999719927181067 0.999484996631079 0.999865686288203 0 0 0.30849710781876 0 0 0.336267116879942 0 0 0.30849710781876 0 0 1.90780977028248 0.219223304182763 249 4975 False False 0 0 1.67996531074212 0 0 0.00038900558066021 0.999719927181067 0.999484996631079 0.999865686288203 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 0 9 6560 26496 0 0 0.000562171107654053 0.999660441426146 0.999355510362951 0.999844720818052 0 0 0.336267116879942 0 0 0.369416647552819 0 0 0.336267116879942 0 0 2.3668645343219 0.369990583605676 229.5 4087 False False 0 0 0 0 0 0 0 0 0 2.04691100627475 0 0 0.000562171107654053 0.999660441426146 0.999355510362951 0.999844720818052 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ile173Val embA_p.Ile173Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Ile196Val embA_p.Ile196Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ile30Val embA_p.Ile30Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ile338Leu embA_p.Ile338Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 7 9481 35698 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 2.61285174975179 0.357638874560194 311 4975 False False 0 0 2.61285174975179 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 7 6560 26498 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 2.80327602229365 0.357905531825047 211.5 4087 False False 0 0 0 0 0 0 0 0 0 2.80327602229365 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ile338Val embA_p.Ile338Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 146.529978407112 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 157.179059039538 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 1 3) Uncertain significance No change no 1 +Ethambutol embA p.Ile412Thr embA_p.Ile412Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3479 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2868 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Ile413Val embA_p.Ile413Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ile43Val embA_p.Ile43Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Ile553Leu embA_p.Ile553Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ile595Val embA_p.Ile595Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 8 9481 35697 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 0 0 0.369416647552819 0 0 0.707598226178713 0 0 0.369416647552819 0 0 9.11425359964974 1 2818.5 4975 False False 0 0 2.20624116275339 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 8 6560 26497 0 0 0.000562171107654053 0.999698170156574 0.999405361976814 0.999869682578628 0 0 0.369416647552819 0 0 0.707598226178713 0 0 0.369416647552819 0 0 9.77799526543077 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 2.36695385477914 0 0 0.000562171107654053 0.999698170156574 0.999405361976814 0.999869682578628 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ile621Val embA_p.Ile621Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3350 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethambutol embA p.Ile637Thr embA_p.Ile637Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3299 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2708 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Ile655Thr embA_p.Ile655Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 1 3 3 4 9478 35701 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999887970872426 0.999713186009257 0.999969475016731 0.428571428571428 0.0989882784425078 0.815948432359917 0.25 0.00630946320970987 0.805879550316756 0.2 0.00505076337946806 0.716417936118089 1.25557431244285 0.0239143524696992 15.6375186292688 1 2818.5 4975 False False 2.82504220299641 0.41374306608866 16.6996717858556 0.000105496360375567 2.67093302808208e-06 0.000587646375974446 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 1 3 3 3 6557 26502 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 0.999886813808715 0.999669257903365 0.999976657677988 0.5 0.118117248757025 0.881882751242974 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 1.34726246759188 0.0256595118209146 16.7804837838729 0.587026005765486 249 4087 False False 0 0 0 0 0 0 0 4.04178740277565 0.541216472236634 30.185737988546 0.000152485513876181 3.86059150860036e-06 0.000849298834468653 0.999886813808715 0.999669257903365 0.999976657677988 1 3) Uncertain significance No change no 1 +Ethambutol embA p.Ile696Leu embA_p.Ile696Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 2 9479 35703 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999943985436213 0.999797670939776 0.99999321630447 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3462 4975 False False 3.76653655448887 0.272970929153834 51.9466713138689 0 0 0.000389087642036349 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 2 6558 26503 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999924542539143 0.999727448570663 0.999990861620785 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2855 4087 False False 0 0 0 0 0 0 0 4.04132357426044 0.292866339798886 55.7129032982466 0 0 0.00056234250533983 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ile696Thr embA_p.Ile696Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Ile821Thr embA_p.Ile821Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ile877Thr embA_p.Ile877Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2793 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ile877Val embA_p.Ile877Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3326 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2727 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ile887Thr embA_p.Ile887Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ile905Val embA_p.Ile905Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 2 5 9 5 9472 35700 0.000949266954962556 0.000434154257137837 0.00180123610483098 0.999859963590533 0.999673232250017 0.999954529045718 0.642857142857142 0.351380110615991 0.87240157014084 0.285714285714285 0.0366925661760855 0.709579136262657 0.285714285714285 0.0366925661760855 0.709579136262657 1.50760135135135 0.143516204694039 9.21060299558887 0.642341324215685 530 4975 False False 6.78420608108108 2.0411144307548 25.7735984286547 0.000211104074308634 2.55667052988578e-05 0.000762370257516042 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 4 1 6556 26504 0.000609756097560975 0.000166162208307701 0.00156047520083291 0.999962271269571 0.999789807096406 0.999999044791703 0.8 0.28358206388191 0.994949236620532 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 4.04270896888346 0.0514937114438758 316.524862422691 0.357320977744167 185.5 4087 False False 0 0 0 0 0 0 0 16.1708358755338 1.59970034177407 792.771744020614 0.000152508769254232 3.86118028152325e-06 0.000849428314837321 0.999962271269571 0.999789807096406 0.999999044791703 2 3) Uncertain significance No change no 1 +Ethambutol embA p.Ile914Val embA_p.Ile914Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3397 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ile916Val embA_p.Ile916Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3446 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2842 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Leu1008Pro embA_p.Leu1008Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 1 3) Uncertain significance No change no 1 +Ethambutol embA p.Leu1037Pro embA_p.Leu1037Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Leu208Phe embA_p.Leu208Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 9480 35702 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99991597815432 0.999754472342108 0.99998267234027 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11649128277037 1 2818.5 4975 False False 1.25534458509142 0.0239099774609589 15.6346568618898 0 0 0.00038904660702099 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Leu212del embA_p.Leu212del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3454 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2849 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Leu215Met embA_p.Leu215Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 9479 35704 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999971992718106 0.999843963402622 0.999999290917266 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 146.569015564619 1 2818.5 4975 False False 7.53328410169849 0.392120325718966 443.147628387906 0 0 0.000389087642036349 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 6558 26504 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999962271269571 0.999789807096406 0.999999044791703 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 157.238712024072 1 1103 4087 False False 0 0 0 0 0 0 0 8.08295211954864 0.420719628662148 475.373667785977 0 0 0.00056234250533983 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Leu215Pro embA_p.Leu215Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embA p.Leu221Met embA_p.Leu221Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Leu227Phe embA_p.Leu227Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3447 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2843 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Leu233Met embA_p.Leu233Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 0 9 0 17 9481 35688 0 0 0.00038900558066021 0.999523876207814 0.999237788774316 0.999722616660517 0 0 0.195064322969093 0 0 0.336267116879942 0 0 0.195064322969093 0 0 1.90743564629395 0.219225473578815 256 4975 False False 0 0 0.912424392898866 0 0 0.00038900558066021 0.999523876207814 0.999237788774316 0.999722616660517 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 0 16 6560 26489 0 0 0.000562171107654053 0.999396340313148 0.99901987910474 0.999654918214049 0 0 0.205907214207822 0 0 0.336267116879942 0 0 0.205907214207822 0 0 2.04637016541598 0.220121959150561 158 4087 False False 0 0 0 0 0 0 0 0 0 1.047384092264 0 0 0.000562171107654053 0.999396340313148 0.99901987910474 0.999654918214049 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Leu261Ser embA_p.Leu261Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Leu263Phe embA_p.Leu263Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Leu263Pro embA_p.Leu263Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Leu278Arg embA_p.Leu278Arg 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 0 1 2 2 9479 35703 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999943985436213 0.999797670939776 0.99999321630447 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 146.564919965648 1 1480 4975 False False 3.76653655448887 0.272970929153834 51.9466713138689 0 0 0.000389087642036349 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 0 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 157.21479794295 1 1103 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Leu27Val embA_p.Leu27Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3362 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2757 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Leu344Arg embA_p.Leu344Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Leu344Pro embA_p.Leu344Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3377 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Leu347Arg embA_p.Leu347Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Leu34Arg embA_p.Leu34Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Leu369Met embA_p.Leu369Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 0.5 0.012579117093425 0.987420882906574 0.333333333333333 0.00840375865961264 0.905700675949754 3.76613924050632 0.0479731565330282 294.924553356571 0.375629145492829 341.5 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 0.5 0.012579117093425 0.987420882906574 0.333333333333333 0.00840375865961264 0.905700675949754 4.04070742491233 0.0514682204381615 316.368591398696 0.357447215329094 201.5 4087 False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Leu373Pro embA_p.Leu373Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 29 1 28 7 33 9474 35672 0.000738318742748655 0.00029689231210758 0.00152062336565454 0.999075759697521 0.998702265560311 0.99936371276009 0.175 0.0733827293520852 0.327790133361585 0.0344827586206896 0.000872646883579922 0.177644295488722 0.0294117647058823 0.00074436423469026 0.153267669560317 0.134473295334599 0.00329205871139044 0.813606749656062 0.0196310283232991 62 4975 False False 0.798689875320654 0.298078701652403 1.83690353079716 0.000105540897097625 2.6720605972471e-06 0.000587894399029927 0.999075759697521 0.998702265560311 0.99936371276009 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 26 1 25 4 29 6556 26476 0.000609756097560975 0.000166162208307701 0.00156047520083291 0.998905866817581 0.998429017222443 0.999267123212173 0.121212121212121 0.0340328814229786 0.28201622853722 0.0384615384615384 0.00097328789333503 0.196369646762539 0.0333333333333333 0.000843570926630479 0.172169455633412 0.161537522879804 0.00393750276412043 0.987207731023897 0.0456012330205735 68 4087 False False 0 0 0 0 0 0 0 0.557025940964844 0.142221087539489 1.58707489901094 0.000152508769254232 3.86118028152325e-06 0.000849428314837321 0.998905866817581 0.998429017222443 0.999267123212173 8 3) Uncertain significance No change no 1 +Ethambutol embA p.Leu390Met embA_p.Leu390Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.975 0 0 0.521823750104981 0 0 146.521788926551 1 1480 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2735 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 4 3) Uncertain significance No change no 1 +Ethambutol embA p.Leu390Val embA_p.Leu390Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Leu417Arg embA_p.Leu417Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Leu452Met embA_p.Leu452Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Leu459Arg embA_p.Leu459Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.058895521352 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 3 3) Uncertain significance No change no 1 +Ethambutol embA p.Leu505Phe embA_p.Leu505Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 11 0 11 0 11 9481 35694 0 0 0.00038900558066021 0.999691919899173 0.999448826618347 0.999846197812 0 0 0.284914152918154 0 0 0.284914152918154 0 0 0.284914152918154 0 0 1.50034693324555 0.135454656941587 149.5 4975 False False 0 0 1.50034693324555 0 0 0.00038900558066021 0.999691919899173 0.999448826618347 0.999846197812 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 0 11 0 11 6560 26494 0 0 0.000562171107654053 0.999584983965289 0.999257543293353 0.999792807866341 0 0 0.284914152918154 0 0 0.284914152918154 0 0 0.284914152918154 0 0 1.60965686204705 0.13661861299788 105 4087 False False 0 0 0 0 0 0 0 0 0 1.60965686204705 0 0 0.000562171107654053 0.999584983965289 0.999257543293353 0.999792807866341 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Leu525Met embA_p.Leu525Met 1 missense_variant (see "Genomic_coordinates" sheet) 2 3 1 2 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 1.88306962025316 0.0319145727646777 36.1783621216076 0.506635653517051 355 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 3 1 2 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 2.02035371245616 0.0342397021387091 38.7759303485373 0.484927822237944 240 4087 False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Leu535Val embA_p.Leu535Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3480 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Leu552Pro embA_p.Leu552Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Leu560Pro embA_p.Leu560Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Leu562Met embA_p.Leu562Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Leu580Pro embA_p.Leu580Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3423 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2815 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Leu62Met embA_p.Leu62Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 157.21479794295 1 1103 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embA p.Leu653Pro embA_p.Leu653Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2833 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Leu656Val embA_p.Leu656Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3404 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Leu659Phe embA_p.Leu659Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 1 5 9480 35700 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999859963590533 0.999673232250017 0.999954529045718 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.602364635616474 0 0 0.521823750104981 0 0 5.70559538331064 0.585903624207148 445 4975 False False 0.753164556962025 0.0159260191955521 6.73154939272228 0 0 0.00038904660702099 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12104088004766 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Leu659Ser embA_p.Leu659Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Leu685Ser embA_p.Leu685Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Leu832Phe embA_p.Leu832Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3287 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2697 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Leu868Pro embA_p.Leu868Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Leu892Val embA_p.Leu892Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Leu894Val embA_p.Leu894Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Leu908Val embA_p.Leu908Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Leu925Val embA_p.Leu925Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Leu964Met embA_p.Leu964Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Leu967Met embA_p.Leu967Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Leu967Val embA_p.Leu967Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3455 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2850 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Lys1012Met embA_p.Lys1012Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Lys1012Thr embA_p.Lys1012Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Lys166Asn embA_p.Lys166Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 8 9481 35697 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 3398 4975 False False 0 0 2.20624116275339 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 8 6560 26497 0 0 0.000562171107654053 0.999698170156574 0.999405361976814 0.999869682578628 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 2794 4087 False False 0 0 0 0 0 0 0 0 0 2.36695385477914 0 0 0.000562171107654053 0.999698170156574 0.999405361976814 0.999869682578628 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Lys488Asn embA_p.Lys488Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12104088004766 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Lys488Met embA_p.Lys488Met 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3486 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2874 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Lys773Asn embA_p.Lys773Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.11527461591697 1 2818.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.77947080093164 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Lys789Gln embA_p.Lys789Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Lys801Arg embA_p.Lys801Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Lys816Asn embA_p.Lys816Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Met153Thr embA_p.Met153Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3327 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 2728 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 4 3) Uncertain significance No change no 1 +Ethambutol embA p.Met153Val embA_p.Met153Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 157.21479794295 1 1103 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Met207Ile embA_p.Met207Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3328 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2729 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Met218Leu embA_p.Met218Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3368 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2763 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Met324Val embA_p.Met324Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Met668Ile embA_p.Met668Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Met697Val embA_p.Met697Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 3 9480 35702 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99991597815432 0.999754472342108 0.99998267234027 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.0610057960224 1 2818.5 4975 False False 1.25534458509142 0.0239099774609589 15.6346568618898 0 0 0.00038904660702099 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 157.208880998325 1 2276.5 4087 False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 0 0 0.000562256793434776 0.999924542539143 0.999727448570663 0.999990861620785 2 3) Uncertain significance No change no 1 +Ethambutol embA p.Met705Thr embA_p.Met705Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Met735Ile embA_p.Met735Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Met735Thr embA_p.Met735Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3437 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2834 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Met840Val embA_p.Met840Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Phe1030Leu embA_p.Phe1030Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3438 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Phe174Leu embA_p.Phe174Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Phe342Val embA_p.Phe342Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3334 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2736 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Phe362Val embA_p.Phe362Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Phe368Leu embA_p.Phe368Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3310 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2716 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Phe471Leu embA_p.Phe471Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance No change no 1 +Ethambutol embA p.Phe499Cys embA_p.Phe499Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Phe529Leu embA_p.Phe529Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Phe533Leu embA_p.Phe533Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3399 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Phe590Ser embA_p.Phe590Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Phe650Leu embA_p.Phe650Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Phe666Leu embA_p.Phe666Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3411 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Phe830Leu embA_p.Phe830Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Phe912Leu embA_p.Phe912Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 1 9477 35704 0.000421896424427802 0.000114964157806894 0.00107986688593449 0.999971992718106 0.999843963402622 0.999999290917266 0.8 0.28358206388191 0.994949236620532 NA NA NA 0 0 0.975 NA NA NA NA 3290 4975 False False 15.0697478104885 1.49093500364622 739.038051857485 0 0 0.000389169738041761 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 1 6557 26504 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 0.999962271269571 0.999789807096406 0.999999044791703 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 2700 4087 False False 0 0 0 0 0 0 0 12.1262772609425 0.973374031902014 634.171386087929 0 0 0.000562428243381166 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embA p.Phe927Leu embA_p.Phe927Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Phe987Leu embA_p.Phe987Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Pro1065Leu embA_p.Pro1065Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Pro1065Thr embA_p.Pro1065Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Pro1082Leu embA_p.Pro1082Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Pro1087Arg embA_p.Pro1087Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3351 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Pro1087Ser embA_p.Pro1087Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Pro1094Ser embA_p.Pro1094Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Pro1094Thr embA_p.Pro1094Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Pro156Leu embA_p.Pro156Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 3 9480 35702 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99991597815432 0.999754472342108 0.99998267234027 0.25 0.00630946320970987 0.805879550316756 0 0 0.975 0 0 0.707598226178713 0 0 146.545399763461 1 2818.5 4975 False False 1.25534458509142 0.0239099774609589 15.6346568618898 0 0 0.00038904660702099 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 3 6559 26502 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999886813808715 0.999669257903365 0.999976657677988 0.25 0.00630946320970987 0.805879550316756 0 0 0.975 0 0 0.707598226178713 0 0 157.202964052604 1 2276.5 4087 False False 0 0 0 0 0 0 0 1.34685165421558 0.025651688752077 16.7753654027497 0 0 0.000562256793434776 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Pro156Ser embA_p.Pro156Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3279 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2689 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Pro163Leu embA_p.Pro163Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Pro164Ala embA_p.Pro164Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Pro164Leu embA_p.Pro164Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Pro164Ser embA_p.Pro164Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Pro242Arg embA_p.Pro242Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3352 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethambutol embA p.Pro2Thr embA_p.Pro2Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3440 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Pro327His embA_p.Pro327His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Pro327Leu embA_p.Pro327Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Pro327Ser embA_p.Pro327Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Pro349Leu embA_p.Pro349Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3369 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2764 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Pro381Leu embA_p.Pro381Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Pro383Ser embA_p.Pro383Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 67 9480 35638 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.998123512113149 0.997617530501414 0.998545460831816 0.0147058823529411 0.00037225140289861 0.079233989912788 NA NA NA 0 0 0.0535696541270968 NA NA NA NA NA NA False True 0.056108697021223 0.00140390558670019 0.323596085614818 0 0 0.00038904660702099 0.998123512113149 0.997617530501414 0.998545460831816 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 1 58 6559 26447 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.997811733635163 0.997172064607892 0.998337951124302 0.0169491525423728 0.000429023332723594 0.0908559328866492 NA NA NA 0 0 0.0616210089039198 NA NA NA NA NA NA False True 1 1 1 0 0 1 1 0.069520164448954 0.00173441509351777 0.403138407665929 0 0 0.000562256793434776 0.997811733635163 0.997172064607892 0.998337951124302 1 Not assoc w R 5) Not assoc w R No change yes 1 +Ethambutol embA p.Pro431Gln embA_p.Pro431Gln 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3378 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2772 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Pro455Arg embA_p.Pro455Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3391 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2786 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Pro455Gln embA_p.Pro455Gln 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3311 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2717 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Pro455Leu embA_p.Pro455Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Pro491Leu embA_p.Pro491Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3441 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2836 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Pro548Leu embA_p.Pro548Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3494 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Pro639Ser embA_p.Pro639Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 16 58 9465 35647 0.00168758569771121 0.00096489905765009 0.00273909056442828 0.998375577650189 0.997900556820432 0.998766284052575 0.216216216216216 0.128932972309865 0.32723696966393 NA NA NA 0 0 0.0616210089039198 NA NA NA NA NA NA False True 1.0389493050622 0.55720506386012 1.83284189049688 0 0 0.000389663042518041 0.998375577650189 0.997900556820432 0.998766284052575 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 16 57 6544 26448 0.0024390243902439 0.00139473586445882 0.00395780883041526 0.997849462365591 0.997214614987384 0.99837080933495 0.21917808219178 0.130780746969945 0.331384004620654 NA NA NA 0 0 0.0626674809144849 NA NA NA NA NA NA False True 0 0 1 0 0 1 1 1.13447432762836 0.607641758467291 2.00468938783429 0 0 0.000563545221770202 0.997849462365591 0.997214614987384 0.99837080933495 4 Not assoc w R Literature evidence (PMID 32143680) 4) Not assoc w R - Interim DOWN from NotAwR to NotAwRI yes Lit. (PMID 32143680) 3 +Ethambutol embA p.Pro645Arg embA_p.Pro645Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3412 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2804 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Pro645Gln embA_p.Pro645Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 8 9481 35697 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 0 0 0.369416647552819 0 0 0.521823750104981 0 0 0.369416647552819 0 0 4.10948297692623 0.590982254518448 523.5 4975 False False 0 0 2.20624116275339 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 8 6560 26497 0 0 0.000562171107654053 0.999698170156574 0.999405361976814 0.999869682578628 0 0 0.369416647552819 0 0 0.521823750104981 0 0 0.369416647552819 0 0 4.40893250203607 0.590384982702355 253.5 4087 False False 0 0 0 0 0 0 0 0 0 2.36695385477914 0 0 0.000562171107654053 0.999698170156574 0.999405361976814 0.999869682578628 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Pro689Leu embA_p.Pro689Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3400 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2795 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Pro714Ser embA_p.Pro714Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.096562813829025 Inf 0.209821626167397 198.5 4975 False False Inf 0.096562813829025 Inf 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Pro745Leu embA_p.Pro745Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Pro752Leu embA_p.Pro752Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Pro754Ala embA_p.Pro754Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Pro75Leu embA_p.Pro75Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.841886116991581 0 0 0.521823750104981 0 0 20.0577749283512 1 2818.5 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.841886116991581 0 0 0.521823750104981 0 0 21.5157135377061 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Pro763Leu embA_p.Pro763Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3463 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Pro763Ser embA_p.Pro763Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Pro774His embA_p.Pro774His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 146.54949493291 1 1480 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 157.208880998325 1 2276.5 4087 False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 0 0 0.000562256793434776 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Pro774Ser embA_p.Pro774Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Pro802Leu embA_p.Pro802Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Pro838Ala embA_p.Pro838Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3413 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Pro838Leu embA_p.Pro838Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 1 3) Uncertain significance No change no 1 +Ethambutol embA p.Pro838Ser embA_p.Pro838Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Pro860Leu embA_p.Pro860Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Pro861Ser embA_p.Pro861Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Pro864Gln embA_p.Pro864Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3473 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Pro867Ser embA_p.Pro867Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3487 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Pro901Leu embA_p.Pro901Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 15 0 15 1 21 9480 35684 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99941184708024 0.99910108554872 0.999635888372764 0.0454545454545454 0.00115014752657357 0.228444397667633 0 0 0.218019360910534 0 0 0.161097615219079 0 0 1.04969927323875 0.0524895499554361 102 4975 False False 0.179244524814145 0.00433752716575256 1.11481522031563 0 0 0.00038904660702099 0.99941184708024 0.99910108554872 0.999635888372764 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 15 0 15 1 20 6559 26485 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999245425391435 0.998834860097994 0.999539027227828 0.0476190476190476 0.00120488344836351 0.238159909936821 0 0 0.218019360910534 0 0 0.168433470983085 0 0 1.12616152415937 0.0535001314805279 71 4087 False False 0 0 0 0 0 0 0 0.201898155206586 0.00487402352307712 1.26281197655001 0 0 0.000562256793434776 0.999245425391435 0.998834860097994 0.999539027227828 5 3) Uncertain significance No change no 1 +Ethambutol embA p.Pro913Leu embA_p.Pro913Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Pro913Ser embA_p.Pro913Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 309 3627 9172 32078 0.0325914987870477 0.029108781790712 0.0363650880540726 0.898417588573029 0.895237590781242 0.901532614024076 0.0785060975609756 0.0702916409950649 0.0873525364986465 NA NA NA 0 0 0.00101654375037574 NA NA NA NA NA NA False True 0.297957389645979 0.263827317182657 0.335584221395587 0 0 0.000402108344940365 0.898417588573029 0.895237590781242 0.901532614024076 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 226 3014 6334 23491 0.0344512195121951 0.0301694970878531 0.0391529754304444 0.886285606489341 0.882402430040605 0.890083872758291 0.069753086419753 0.061219074156533 0.0790731969262774 NA NA NA 0 0 0.00122316620357391 NA NA NA NA NA NA False True 1 1 1 0 0 1 1 0.278092090610096 0.241141297503621 0.319419341074258 0 0 0.000582223788000137 0.886285606489341 0.882402430040605 0.890083872758291 639 Not assoc w R 5) Not assoc w R No change yes 1 +Ethambutol embA p.Pro918Ser embA_p.Pro918Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3495 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2880 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Pro933Ala embA_p.Pro933Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Pro934Arg embA_p.Pro934Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3442 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2837 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Pro934Ser embA_p.Pro934Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Pro958Leu embA_p.Pro958Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Pro976Leu embA_p.Pro976Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Pro976Thr embA_p.Pro976Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Pro988Leu embA_p.Pro988Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ser1017Ala embA_p.Ser1017Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ser1024Asn embA_p.Ser1024Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ser1024Cys embA_p.Ser1024Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3414 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2805 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ser1025Ala embA_p.Ser1025Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ser1025Leu embA_p.Ser1025Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ser1040Leu embA_p.Ser1040Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ser137Asn embA_p.Ser137Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3280 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2690 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ser20Ala embA_p.Ser20Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 8 9481 35697 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 3363 4975 False False 0 0 2.20624116275339 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 6560 26499 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 2758 4087 False False 0 0 0 0 0 0 0 0 0 3.43165838346939 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ser20Pro embA_p.Ser20Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 4.10971321225031 0.590981128432313 516.5 4975 False False 0 0 3.19822685561766 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 6 6560 26499 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 4.40926527811573 0.590385229079199 260 4087 False False 0 0 0 0 0 0 0 0 0 3.43165838346939 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 1 3) Uncertain significance No change no 1 +Ethambutol embA p.Ser250Arg embA_p.Ser250Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Ser250Asn embA_p.Ser250Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ser250Gly embA_p.Ser250Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ser309Ala embA_p.Ser309Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Ser318Thr embA_p.Ser318Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3415 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2806 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ser340Asn embA_p.Ser340Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ser49Arg embA_p.Ser49Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3496 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 2881 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 4 3) Uncertain significance No change no 1 +Ethambutol embA p.Ser514Pro embA_p.Ser514Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ser516Cys embA_p.Ser516Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ser516Pro embA_p.Ser516Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ser643Asn embA_p.Ser643Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3364 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2759 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Ser654Leu embA_p.Ser654Leu 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 0 1 2 1 9479 35704 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999971992718106 0.999843963402622 0.999999290917266 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 146.569015564619 1 2818.5 4975 False False 7.53328410169849 0.392120325718966 443.147628387906 0 0 0.000389087642036349 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ser727Asn embA_p.Ser727Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 157.21479794295 1 1103 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ser731Phe embA_p.Ser731Phe 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3370 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2765 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 1 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Ser768Arg embA_p.Ser768Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3428 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2821 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Ser768Ile embA_p.Ser768Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ser77Pro embA_p.Ser77Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ser809Phe embA_p.Ser809Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Ser994Phe embA_p.Ser994Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Thr100Ser embA_p.Thr100Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embA p.Thr1014Ala embA_p.Thr1014Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Thr1080Ala embA_p.Thr1080Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Thr1080Asn embA_p.Thr1080Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Thr1080Pro embA_p.Thr1080Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 3 9480 35702 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99991597815432 0.999754472342108 0.99998267234027 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.0610057960224 1 2818.5 4975 False False 1.25534458509142 0.0239099774609589 15.6346568618898 0 0 0.00038904660702099 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 3 6559 26502 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999886813808715 0.999669257903365 0.999976657677988 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 21.5206089807014 1 2276.5 4087 False False 0 0 0 0 0 0 0 1.34685165421558 0.025651688752077 16.7753654027497 0 0 0.000562256793434776 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Thr1080Ser embA_p.Thr1080Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3353 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Thr113Arg embA_p.Thr113Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 7 9481 35698 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 2.61285174975179 0.357638874560194 311 4975 False False 0 0 2.61285174975179 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.40943166615857 0.590385352956204 278 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Thr113Met embA_p.Thr113Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Thr161Ile embA_p.Thr161Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3371 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2766 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Thr175Ala embA_p.Thr175Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3372 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2767 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Thr197Arg embA_p.Thr197Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Thr232Pro embA_p.Thr232Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3401 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2796 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Thr238Asn embA_p.Thr238Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Thr238Ile embA_p.Thr238Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Thr238Ser embA_p.Thr238Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Thr270Pro embA_p.Thr270Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2787 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Thr300Ala embA_p.Thr300Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Thr300Met embA_p.Thr300Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.10982832991351 0.590980565810755 492 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.40943166615857 0.590385352956204 278 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Thr300Pro embA_p.Thr300Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Thr308Ala embA_p.Thr308Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 0 50 9481 35655 0 0 0.00038900558066021 0.998599635905335 0.998154206154326 0.998960449649607 0 0 0.0711217364641976 NA NA NA 0 0 0.0711217364641976 NA NA NA NA NA NA False True 0 0 0.288026574755757 0 0 0.00038900558066021 0.998599635905335 0.998154206154326 0.998960449649607 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 0 46 6560 26459 0 0 0.000562171107654053 0.998264478400302 0.997685728208481 0.998729108515818 0 0 0.0770618270519006 NA NA NA 0 0 0.0770618270519006 NA NA NA NA NA NA False True 1 1 1 0 0 1 0 0 0 0.336895686124446 0 0 0.000562171107654053 0.998264478400302 0.997685728208481 0.998729108515818 14 Not assoc w R 5) Not assoc w R No change yes 1 +Ethambutol embA p.Thr308Ile embA_p.Thr308Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Thr308Lys embA_p.Thr308Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Thr308Pro embA_p.Thr308Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3281 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 2691 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 4 3) Uncertain significance No change no 1 +Ethambutol embA p.Thr329Asn embA_p.Thr329Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3291 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Thr363Ile embA_p.Thr363Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Thr39Ile embA_p.Thr39Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Thr40Ala embA_p.Thr40Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3443 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2838 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Thr40Ile embA_p.Thr40Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3416 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2807 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Thr420Met embA_p.Thr420Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Thr434Ala embA_p.Thr434Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Ethambutol embA p.Thr434Pro embA_p.Thr434Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Thr467Asn embA_p.Thr467Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Thr478Ala embA_p.Thr478Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3379 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2773 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Thr478Met embA_p.Thr478Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.096562813829025 Inf 0.209821626167397 198.5 4975 False False Inf 0.096562813829025 Inf 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.103599830448027 Inf 0.198397096627854 142 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Thr566Met embA_p.Thr566Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Thr568Ile embA_p.Thr568Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Thr56Pro embA_p.Thr56Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3481 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2869 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Thr588Ile embA_p.Thr588Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Thr591Ala embA_p.Thr591Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3318 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2722 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Thr591Pro embA_p.Thr591Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Thr604Arg embA_p.Thr604Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Thr604Met embA_p.Thr604Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embA p.Thr608Asn embA_p.Thr608Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 39 4 35 75 39 9406 35666 0.0079105579580213 0.00622709294693484 0.00990599781850098 0.998907716006161 0.998507111173478 0.999223167585189 0.657894736842105 0.563182387216833 0.744179791031807 0.102564102564102 0.0286601051260963 0.242209726950617 0.0930232558139534 0.0259312902663234 0.221353445381386 0.433352571307068 0.111849632485789 1.21242765516493 0.116328007422857 133 4975 False False 7.29199038257086 4.88534697863608 11.0373990924785 0.000425079702444208 0.000115831669375216 0.00108801195707136 0.998907716006161 0.998507111173478 0.999223167585189 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 37 2 35 60 38 6500 26467 0.00914634146341463 0.00698667297704131 0.0117576709883518 0.998566308243727 0.998032671713558 0.998985240811267 0.612244897959183 0.508486185098785 0.709028976466044 0.054054054054054 0.00661457041152882 0.181949118377749 0.05 0.00611364659935083 0.169196863959417 0.232676923076923 0.0271163219478762 0.90608151955828 0.0229854916113963 53 4087 False False 0 0 0 0 0 0 0 6.42923076923076 4.20835646306746 9.93066111423571 0.000307597662257766 3.72536749514981e-05 0.0011107021760088 0.998566308243727 0.998032671713558 0.998985240811267 4 3) Uncertain significance No change no 1 +Ethambutol embA p.Thr652Arg embA_p.Thr652Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 3 1 9478 35704 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999971992718106 0.999843963402622 0.999999290917266 0.75 0.194120449683243 0.99369053679029 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 3.76703945980164 0.0479846225105715 294.994865238518 0.375566530700865 328.5 4975 False False 11.3011183794049 0.90722384791697 591.183089908516 0.000105496360375567 2.67093302808208e-06 0.000587646375974446 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 4.04085988717792 0.0514701624188962 316.380494544091 0.35743759524028 195 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Thr652Lys embA_p.Thr652Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 7 3 9474 35702 0.000738318742748655 0.00029689231210758 0.00152062336565454 0.99991597815432 0.999754472342108 0.99998267234027 0.7 0.347547149940002 0.933260488822265 0.5 0.012579117093425 0.987420882906574 0.25 0.00630946320970987 0.805879550316756 3.76841883048342 0.0480021908797003 295.102601983936 0.375470630665397 326 4975 False False 8.79297727112799 2.00679427251216 52.716257751683 0.000105540897097625 2.6720605972471e-06 0.000587894399029927 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 4 1 6556 26504 0.000609756097560975 0.000166162208307701 0.00156047520083291 0.999962271269571 0.999789807096406 0.999999044791703 0.8 0.28358206388191 0.994949236620532 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 4.04270896888346 0.0514937114438758 316.524862422691 0.357320977744167 185.5 4087 False False 0 0 0 0 0 0 0 16.1708358755338 1.59970034177407 792.771744020614 0.000152508769254232 3.86118028152325e-06 0.000849428314837321 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embA p.Thr652Met embA_p.Thr652Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Thr657Pro embA_p.Thr657Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Thr674Asn embA_p.Thr674Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3335 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2737 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Thr688Met embA_p.Thr688Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Thr718Ile embA_p.Thr718Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3343 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2744 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Thr728Ile embA_p.Thr728Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.10982832991351 0.590980565810755 492 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.40943166615857 0.590385352956204 278 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Thr81Ala embA_p.Thr81Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Thr837Ala embA_p.Thr837Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Thr853Ala embA_p.Thr853Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 8 9481 35697 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 0 0 0.369416647552819 0 0 0.4592581264399 0 0 0.369416647552819 0 0 3.19804752107404 0.354692794889658 274.5 4975 False False 0 0 2.20624116275339 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 8 6560 26497 0 0 0.000562171107654053 0.999698170156574 0.999405361976814 0.999869682578628 0 0 0.369416647552819 0 0 0.4592581264399 0 0 0.369416647552819 0 0 3.43139939855491 0.605987594467308 325 4087 False False 0 0 0 0 0 0 0 0 0 2.36695385477914 0 0 0.000562171107654053 0.999698170156574 0.999405361976814 0.999869682578628 1 3) Uncertain significance No change no 1 +Ethambutol embA p.Thr899Ala embA_p.Thr899Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Thr899Ser embA_p.Thr899Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Thr983Ala embA_p.Thr983Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Thr983Asn embA_p.Thr983Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Thr983Ile embA_p.Thr983Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Trp1050Gly embA_p.Trp1050Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Trp1054Ser embA_p.Trp1054Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3292 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2701 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Trp142Arg embA_p.Trp142Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3344 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2745 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Trp306Arg embA_p.Trp306Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 1 6 8 12 9473 35693 0.000843792848855605 0.000364358012393849 0.00166192766222289 0.99966391261728 0.999412996653316 0.999826327071809 0.4 0.191190060725307 0.63945741269251 0.142857142857142 0.00361029686190058 0.578723197043195 0.0769230769230769 0.00194562849734675 0.360297435267877 0.627977761356838 0.0136545854415831 5.17743958706034 1 2818.5 4975 False False 2.51191104542735 0.890363508306432 6.68478167232564 0.000105552037154317 2.67234263830968e-06 0.000587956437510075 0.99966391261728 0.999412996653316 0.999826327071809 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 1 6 8 10 6552 26495 0.00121951219512195 0.000526641184096925 0.00240150352406598 0.999622712695717 0.999306265033238 0.999819061720012 0.444444444444444 0.215301507387299 0.692428341001244 0.142857142857142 0.00361029686190058 0.578723197043195 0.0909090909090909 0.00229897221381426 0.412779916988382 0.673967236467236 0.0146535829526833 5.55752215297716 1 2276.5 4087 False False 0 0 0 0 0 0 0 3.23504273504273 1.10899445327917 9.10650283554102 0.000152601861742713 3.86353717016821e-06 0.000849946631353037 0.999622712695717 0.999306265033238 0.999819061720012 4 3) Uncertain significance No change no 1 +Ethambutol embA p.Trp306Gly embA_p.Trp306Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Trp393Ser embA_p.Trp393Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 1 6 9480 35699 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99983195630864 0.999634275787128 0.999938328510354 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.19856457868224 0.354707391351733 301 4975 False False 0.627619549929676 0.0136468000350686 5.17448319653473 0 0 0.00038904660702099 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 1 6 6559 26499 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.99977362761743 0.99950734823901 0.999916920939814 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.4321816796478 0.605970495275696 304 4087 False False 0 0 0 0 0 0 0 0.673349595974996 0.0146401601947477 5.55241977196973 0 0 0.000562256793434776 0.99977362761743 0.99950734823901 0.999916920939814 1 3) Uncertain significance No change no 1 +Ethambutol embA p.Trp45Gly embA_p.Trp45Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Trp495Cys embA_p.Trp495Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3312 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2718 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Trp624Cys embA_p.Trp624Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Trp634Ser embA_p.Trp634Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Tyr276Cys embA_p.Tyr276Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Tyr289Cys embA_p.Tyr289Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Tyr296His embA_p.Tyr296His 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 14 9481 35691 0 0 0.00038900558066021 0.999607898053494 0.999342206985133 0.999785618166341 0 0 0.231635761650116 NA NA NA 0 0 0.231635761650116 NA NA NA NA 3488 4975 False False 0 0 1.13511057396106 0 0 0.00038900558066021 0.999607898053494 0.999342206985133 0.999785618166341 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 14 6560 26491 0 0 0.000562171107654053 0.999471797774004 0.999113925067086 0.999711197799087 0 0 0.231635761650116 NA NA NA 0 0 0.231635761650116 NA NA NA NA 2875 4087 False False 0 0 0 0 0 0 0 0 0 1.21779664057642 0 0 0.000562171107654053 0.999471797774004 0.999113925067086 0.999711197799087 1 3) Uncertain significance No change no 1 +Ethambutol embA p.Tyr307His embA_p.Tyr307His 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Tyr502Cys embA_p.Tyr502Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 1 3) Uncertain significance No change no 1 +Ethambutol embA p.Tyr635Cys embA_p.Tyr635Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3405 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2799 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Tyr635His embA_p.Tyr635His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Tyr664His embA_p.Tyr664His 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3431 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2826 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Val1073Ala embA_p.Val1073Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3432 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2827 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Val1073Ile embA_p.Val1073Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 0 9 0 9 9481 35696 0 0 0.00038900558066021 0.99974793446296 0.999521555266748 0.999884733314884 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.336267116879942 0 0 1.90786321657339 0.219222996504786 244.5 4975 False False 0 0 1.90786321657339 0 0 0.00038900558066021 0.99974793446296 0.999521555266748 0.999884733314884 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 1 3) Uncertain significance No change no 1 +Ethambutol embA p.Val1074Ala embA_p.Val1074Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2738 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Val1078Met embA_p.Val1078Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3464 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2856 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Val107Ile embA_p.Val107Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3300 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2709 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Val1081Met embA_p.Val1081Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Val125Glu embA_p.Val125Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Val170Phe embA_p.Val170Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3465 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2857 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Val18Ile embA_p.Val18Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Val206Ile embA_p.Val206Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3497 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Val206Met embA_p.Val206Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 141 2143 9340 33562 0.01487184896108 0.0125326292099037 0.0175156159181175 0.939980394902674 0.937466680240042 0.942422244966538 0.0617338003502627 0.0522120854113178 0.0723978076024873 0 0 0.841886116991581 0 0 0.00171988162670388 0 0 19.134930738526 1 NA NA False True 0.236427450161423 0.197655363582228 0.280930736155481 0 0 0.000394876989225373 0.939980394902674 0.937466680240042 0.942422244966538 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 2 0 2 117 1689 6443 24816 0.0178353658536585 0.0147720830296928 0.0213372649739631 0.936276174306734 0.9332685665959 0.939187697460503 0.0647840531561461 0.0538694903278526 0.0771369134636232 0 0 0.841886116991581 0 0 0.00218167792534605 0 0 20.5165195584291 1 NA NA False True 1 1 1 0 0 1 1 0.266808622904116 0.21886806263978 0.322642676017224 0 0 0.000572376787038516 0.936276174306734 0.9332685665959 0.939187697460503 315 Not assoc w R 5) Not assoc w R No change yes 1 +Ethambutol embA p.Val244Met embA_p.Val244Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3466 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2858 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Val246Gly embA_p.Val246Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Val266Ala embA_p.Val266Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3336 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2739 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Val283Leu embA_p.Val283Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Val310Ala embA_p.Val310Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3482 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Val317Leu embA_p.Val317Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.10982832991351 0.590980565810755 492 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.40943166615857 0.590385352956204 278 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Val31Ala embA_p.Val31Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 18 0 18 2 23 9479 35682 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999355832516454 0.999033588308985 0.99959161063274 0.08 0.00983959001879751 0.260305842105214 0 0 0.185301968137852 0 0 0.148185128915224 0 0 0.856391827143707 0.020353965819411 65 4975 False False 0.327332272253998 0.0374025623440819 1.32514908374572 0 0 0.000389087642036349 0.999355832516454 0.999033588308985 0.99959161063274 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 14 0 14 1 17 6559 26488 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.99935861158272 0.998973272974466 0.999626324627714 0.0555555555555555 0.00140555616736942 0.272943599673368 0 0 0.231635761650116 0 0 0.195064322969093 0 0 1.21784443829545 0.0874864233703825 89 4087 False False 0 0 0 0 0 0 0 0.237554146525205 0.00568691332380032 1.51658119210468 0 0 0.000562256793434776 0.99935861158272 0.998973272974466 0.999626324627714 8 3) Uncertain significance No change no 1 +Ethambutol embA p.Val31Ile embA_p.Val31Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Val31Phe embA_p.Val31Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Val339Ala embA_p.Val339Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3448 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2844 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Val391Ile embA_p.Val391Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 146.529978407112 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Val391Leu embA_p.Val391Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 1 5 1 5 9480 35700 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999859963590533 0.999673232250017 0.999954529045718 0.166666666666666 0.00421074451448947 0.641234578997674 0.166666666666666 0.00421074451448947 0.641234578997674 0.166666666666666 0.00421074451448947 0.641234578997674 0.753164556962025 0.0159260191955521 6.73154939272228 1 2818.5 4975 False False 0.753164556962025 0.0159260191955521 6.73154939272228 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Val394Ala embA_p.Val394Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Val396Met embA_p.Val396Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Val414Met embA_p.Val414Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Val458Ala embA_p.Val458Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Val458Met embA_p.Val458Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3373 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2768 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Val458Pro embA_p.Val458Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Val468Ala embA_p.Val468Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 16 58 9465 35647 0.00168758569771121 0.00096489905765009 0.00273909056442828 0.998375577650189 0.997900556820432 0.998766284052575 0.216216216216216 0.128932972309865 0.32723696966393 NA NA NA 0 0 0.0616210089039198 NA NA NA NA NA NA False True 1.0389493050622 0.55720506386012 1.83284189049688 0 0 0.000389663042518041 0.998375577650189 0.997900556820432 0.998766284052575 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 16 57 6544 26448 0.0024390243902439 0.00139473586445882 0.00395780883041526 0.997849462365591 0.997214614987384 0.99837080933495 0.21917808219178 0.130780746969945 0.331384004620654 NA NA NA 0 0 0.0626674809144849 NA NA NA NA NA NA False True 0 0 0 0 0 1 0 1.13447432762836 0.607641758467291 2.00468938783429 0 0 0.000563545221770202 0.997849462365591 0.997214614987384 0.99837080933495 4 Not assoc w R Previous WHO guidance 4) Not assoc w R - Interim DOWN from NotAwR to NotAwRI yes Prev. WHO 3 +Ethambutol embA p.Val468Met embA_p.Val468Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3408 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Val469Met embA_p.Val469Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12104088004766 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Val470Met embA_p.Val470Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Val479Glu embA_p.Val479Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Val479Met embA_p.Val479Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3337 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2740 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Val489Ile embA_p.Val489Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 146.54949493291 1 1480 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 157.208880998325 1 2276.5 4087 False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 0 0 0.000562256793434776 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Val531Leu embA_p.Val531Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 1 4 4 7 9477 35698 0.000421896424427802 0.000114964157806894 0.00107986688593449 0.999803949026747 0.999596102051779 0.999921173824063 0.363636363636363 0.109263443819098 0.692095284988322 0.2 0.00505076337946806 0.716417936118089 0.125 0.0031597235312519 0.526509670875206 0.941700960219478 0.0191197586320744 9.51525379195439 1 1480 4975 False False 2.15245933764452 0.461979395375095 8.46847464077314 0.000105507491031863 2.67121483114821e-06 0.000587708362116832 0.999803949026747 0.999596102051779 0.999921173824063 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 1 4 4 5 6556 26500 0.000609756097560975 0.000166162208307701 0.00156047520083291 0.999811356347858 0.999559824020536 0.9999387451734 0.444444444444444 0.136995662265166 0.787991493221131 0.2 0.00505076337946806 0.716417936118089 0.166666666666666 0.00421074451448947 0.641234578997674 1.01052471018913 0.0205161742712827 10.2169891351565 1 1103 4087 False False 0 0 0 0 0 0 0 3.23367907260524 0.641440578643857 15.0221157142297 0.000152508769254232 3.86118028152325e-06 0.000849428314837321 0.999811356347858 0.999559824020536 0.9999387451734 5 3) Uncertain significance No change no 1 +Ethambutol embA p.Val534Gly embA_p.Val534Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3338 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Val534Leu embA_p.Val534Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Val534Met embA_p.Val534Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3467 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2859 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Val541Ala embA_p.Val541Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3374 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2769 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Val541Met embA_p.Val541Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Val558Leu embA_p.Val558Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 5.70499352101301 0.585896604883905 379.5 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 6.12080991862283 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 2 3) Uncertain significance No change no 1 +Ethambutol embA p.Val607Met embA_p.Val607Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Val613Met embA_p.Val613Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Val627Ala embA_p.Val627Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Val63Ile embA_p.Val63Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.10982832991351 0.590980565810755 492 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.40943166615857 0.590385352956204 278 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Val640Phe embA_p.Val640Phe 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3380 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2774 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Val676Ala embA_p.Val676Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Val676Ile embA_p.Val676Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Val693dup embA_p.Val693dup 1 inframe_insertion (see "Genomic_coordinates" sheet) 1 11 1 10 1 10 9480 35695 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999719927181067 0.999484996631079 0.999865686288203 0.0909090909090909 0.00229897221381426 0.412779916988382 0.0909090909090909 0.00229897221381426 0.412779916988382 0.0909090909090909 0.00229897221381426 0.412779916988382 0.376529535864978 0.00867884780074745 2.64739955416065 0.477494359092655 343 4975 False False 0.376529535864978 0.00867884780074745 2.64739955416065 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999719927181067 0.999484996631079 0.999865686288203 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 1 10 1 10 6559 26495 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999622712695717 0.999306265033238 0.999819061720012 0.0909090909090909 0.00229897221381426 0.412779916988382 0.0909090909090909 0.00229897221381426 0.412779916988382 0.0909090909090909 0.00229897221381426 0.412779916988382 0.403948772678762 0.0093101143677691 2.84045345095752 0.704108029278717 334 4087 False False 0 0 0 0 0 0 0 0.403948772678762 0.0093101143677691 2.84045345095752 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999622712695717 0.999306265033238 0.999819061720012 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Val695Ala embA_p.Val695Ala 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 0 1 3 2 9478 35703 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999943985436213 0.999797670939776 0.99999321630447 0.6 0.146632799634673 0.947255049473683 0 0 0.975 0 0 0.841886116991581 0 0 146.580348245845 1 1480 4975 False False 5.65040092846592 0.647137685918782 67.7491623796885 0 0 0.000389128685709026 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 0 1 3 1 6557 26504 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 0.999962271269571 0.999789807096406 0.999999044791703 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 157.262633381485 1 1103 4087 False False 0 0 0 0 0 0 0 12.1262772609425 0.973374031902014 634.171386087929 0 0 0.000562428243381166 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Val695Met embA_p.Val695Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 10 9481 35695 0 0 0.00038900558066021 0.999719927181067 0.999484996631079 0.999865686288203 0 0 0.30849710781876 0 0 0.409616397225003 0 0 0.30849710781876 0 0 2.61263219582167 0.357640244192598 321 4975 False False 0 0 1.67996531074212 0 0 0.00038900558066021 0.999719927181067 0.999484996631079 0.999865686288203 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 9 6560 26496 0 0 0.000562171107654053 0.999660441426146 0.999355510362951 0.999844720818052 0 0 0.336267116879942 0 0 0.4592581264399 0 0 0.336267116879942 0 0 3.43126990609889 0.605990426414266 327 4087 False False 0 0 0 0 0 0 0 0 0 2.04691100627475 0 0 0.000562171107654053 0.999660441426146 0.999355510362951 0.999844720818052 3 3) Uncertain significance No change no 1 +Ethambutol embA p.Val698Ala embA_p.Val698Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3474 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2863 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Val698Ile embA_p.Val698Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Val739Met embA_p.Val739Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3293 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2702 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Val786Leu embA_p.Val786Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3345 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2746 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Val819Ile embA_p.Val819Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embA p.Val870Leu embA_p.Val870Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Val871dup embA_p.Val871dup 1 inframe_insertion (see "Genomic_coordinates" sheet) 0 0 0 0 2 4 9479 35701 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999887970872426 0.999713186009257 0.999969475016731 0.333333333333333 0.0432718682927417 0.777221904496487 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3468 4975 False False 1.88316278088405 0.170308362439121 13.1422755166224 0 0 0.000389087642036349 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2860 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 3 3) Uncertain significance No change no 1 +Ethambutol embA p.Val898Ile embA_p.Val898Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3339 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Val898Phe embA_p.Val898Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2775 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Val89Ala embA_p.Val89Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3365 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2760 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Val89Met embA_p.Val89Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Val911Ala embA_p.Val911Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Val911Gly embA_p.Val911Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Val911Ile embA_p.Val911Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 14 9480 35691 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999607898053494 0.999342206985133 0.999785618166341 0.0666666666666666 0.0016864302413527 0.319484566578303 0 0 0.975 0 0 0.231635761650116 0 0 146.500352864849 1 2818.5 4975 False False 0.268919529837251 0.00636280625779473 1.7679218975043 0 0 0.00038904660702099 0.999607898053494 0.999342206985133 0.999785618166341 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 7 6560 26498 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 0 0 0.409616397225003 0 0 0.975 0 0 0.409616397225003 0 0 157.15539483586 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 2.80327602229365 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Val938Leu embA_p.Val938Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3340 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2741 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embA p.Val98Ala embA_p.Val98Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embA p.Val98Leu embA_p.Val98Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.058895521352 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance No change no 1 +Ethambutol embB c.1002C>T embB_c.1002C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 20 9480 35685 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999439854362134 0.999135032404509 0.999657815983264 0.0476190476190476 0.00120488344836351 0.238159909936821 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.188212025316455 0.00454413367739119 1.17708731774393 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 6 6560 26499 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.43165838346939 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1005C>T embB_c.1005C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1008G>A embB_c.1008G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.88306962025316 0.0319145727646777 36.1783621216076 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1014G>T embB_c.1014G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1023C>T embB_c.1023C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1029C>A embB_c.1029C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1035C>T embB_c.1035C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 23 9479 35682 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999355832516454 0.999033588308985 0.99959161063274 0.08 0.00983959001879751 0.260305842105214 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.327332272253998 0.0374025623440819 1.32514908374572 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 17 6559 26488 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.99935861158272 0.998973272974466 0.999626324627714 0.0555555555555555 0.00140555616736942 0.272943599673368 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.237554146525205 0.00568691332380032 1.51658119210468 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1053C>T embB_c.1053C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 3 9480 35702 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99991597815432 0.999754472342108 0.99998267234027 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.25534458509142 0.0239099774609589 15.6346568618898 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1056G>A embB_c.1056G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.707313928675496 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1056G>T embB_c.1056G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1065G>A embB_c.1065G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 15 875 9466 34830 0.00158211159160426 0.000885757734327454 0.00260811203671776 0.975493628343369 0.973836672380207 0.977072609864261 0.0168539325842696 0.00946291425358106 0.0276458426409733 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.0630768766412121 0.0351386234459697 0.104683277342375 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 11 829 6549 25676 0.00167682926829268 0.000837354988859942 0.00299832542833478 0.968722882475004 0.96655640778401 0.970785778259237 0.013095238095238 0.00655473210850747 0.0233099597766848 NA NA NA NA NA NA NA NA NA NA NA NA False True 1 1 1 0 0 0 1 0.0520224176252472 0.0258618986928259 0.0936557566137693 NA NA NA NA NA NA 45 5) Not assoc w R Now listed Silent mutation no 0 +Ethambutol embB c.1077A>G embB_c.1077A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1098G>T embB_c.1098G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1101T>C embB_c.1101T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1107G>A embB_c.1107G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1116C>T embB_c.1116C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 8 9481 35697 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.20624116275339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 6 6560 26499 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.43165838346939 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1128G>A embB_c.1128G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1131G>A embB_c.1131G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 6 9479 35699 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.99983195630864 0.999634275787128 0.999938328510354 0.25 0.0318540262499442 0.650855794412824 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.25537152301578 0.123863858669135 7.02323716133577 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1131G>C embB_c.1131G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1137C>A embB_c.1137C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1146C>T embB_c.1146C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 3 9480 35702 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99991597815432 0.999754472342108 0.99998267234027 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.25534458509142 0.0239099774609589 15.6346568618898 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 3 6559 26502 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999886813808715 0.999669257903365 0.999976657677988 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.34685165421558 0.025651688752077 16.7753654027497 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1158G>A embB_c.1158G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1164C>A embB_c.1164C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1164C>G embB_c.1164C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1182G>A embB_c.1182G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.118T>C embB_c.118T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1194C>T embB_c.1194C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1212G>A embB_c.1212G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1233C>A embB_c.1233C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.123G>A embB_c.123G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1242C>T embB_c.1242C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1266C>G embB_c.1266C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1275C>T embB_c.1275C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 4 9480 35701 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999887970872426 0.999713186009257 0.999969475016731 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.941482067510548 0.0191153149568561 9.51304376083015 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 3 6559 26502 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999886813808715 0.999669257903365 0.999976657677988 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.34685165421558 0.025651688752077 16.7753654027497 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1278C>T embB_c.1278C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 7 9481 35698 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.61285174975179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 7 6560 26498 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.80327602229365 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1279C>A embB_c.1279C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1287A>G embB_c.1287A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1290G>A embB_c.1290G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.76624472573839 0.0479745002090283 294.932792118969 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1299G>C embB_c.1299G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.12C>T embB_c.12C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1302C>T embB_c.1302C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1317A>G embB_c.1317A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1323A>C embB_c.1323A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1323A>G embB_c.1323A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1326G>C embB_c.1326G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1338C>T embB_c.1338C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1356G>A embB_c.1356G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1359C>T embB_c.1359C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 45 9 9436 35696 0.00474633477481278 0.00346405306999212 0.00634587080230341 0.99974793446296 0.999521555266748 0.999884733314884 0.833333333333333 0.707058760885614 0.920845563829591 NA NA NA NA NA NA NA NA NA NA NA NA False False 18.9147944044086 9.12560712351246 43.9974706617532 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 38 6 6522 26499 0.00579268292682926 0.00410241205405612 0.00794232427340546 0.99977362761743 0.99950734823901 0.999916920939814 0.863636363636363 0.726493109096176 0.948269170513726 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 25.7324440355719 10.7869968204508 74.4809153713814 NA NA NA NA NA NA 15 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.135G>C embB_c.135G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.135G>T embB_c.135G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1368G>A embB_c.1368G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1371C>A embB_c.1371C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 5 19 9476 35686 0.000527370530534753 0.000171257241502832 0.00123027414547083 0.999467861644027 0.999169124220115 0.999679588507228 0.208333333333333 0.0713186171980549 0.421512843637252 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.99103552464953 0.289129824513314 2.74482704135704 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 13 6559 26492 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999509526504433 0.999161421428146 0.999738818498366 0.0714285714285714 0.00180678065912538 0.338684489931821 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.310694641537757 0.0073132274312288 2.06928814207562 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1374C>T embB_c.1374C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1383G>A embB_c.1383G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1389G>C embB_c.1389G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.138G>A embB_c.138G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1390C>A embB_c.1390C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1392G>C embB_c.1392G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1395C>A embB_c.1395C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.139C>T embB_c.139C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1401G>A embB_c.1401G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1401G>C embB_c.1401G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1404C>T embB_c.1404C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1416G>A embB_c.1416G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1416G>C embB_c.1416G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1419C>T embB_c.1419C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1428G>A embB_c.1428G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1437G>T embB_c.1437G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1443G>C embB_c.1443G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 7 9481 35698 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.61285174975179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 7 6560 26498 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.80327602229365 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.144C>G embB_c.144C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1458C>T embB_c.1458C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.707313928675496 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1470G>A embB_c.1470G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 7 9481 35698 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.61285174975179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 7 6560 26498 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.80327602229365 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1479G>A embB_c.1479G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.147C>T embB_c.147C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 15 9481 35690 0 0 0.00038900558066021 0.9995798907716 0.999307188228015 0.999764849596654 0 0 0.218019360910534 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.04976500705909 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 7 6560 26498 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.80327602229365 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1482C>T embB_c.1482C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1485C>A embB_c.1485C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1488C>T embB_c.1488C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.150G>A embB_c.150G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1515C>T embB_c.1515C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1519A>C embB_c.1519A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.76624472573839 0.0479745002090283 294.932792118969 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1530C>G embB_c.1530C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 21 9481 35684 0 0 0.00038900558066021 0.99941184708024 0.99910108554872 0.999635888372764 0 0 0.161097615219079 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.722928583272661 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1539G>C embB_c.1539G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1542G>A embB_c.1542G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1545C>T embB_c.1545C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1548G>A embB_c.1548G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1551G>A embB_c.1551G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1551G>C embB_c.1551G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 3 4 9478 35701 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999887970872426 0.999713186009257 0.999969475016731 0.428571428571428 0.0989882784425078 0.815948432359917 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.82504220299641 0.41374306608866 16.6996717858556 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1560C>A embB_c.1560C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1560C>G embB_c.1560C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1560C>T embB_c.1560C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.19822685561766 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.40943166615857 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1569G>A embB_c.1569G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1572T>G embB_c.1572T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1587C>T embB_c.1587C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1590G>A embB_c.1590G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1590G>T embB_c.1590G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1593C>T embB_c.1593C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1596C>T embB_c.1596C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1599C>T embB_c.1599C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1602C>T embB_c.1602C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 175 810 9306 34895 0.0184579685687163 0.0158445909142092 0.0213728131220902 0.977314101666433 0.975716242516788 0.978833653776132 0.177664974619289 0.154278962111844 0.20299521691019 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.810127144839516 0.682949153547553 0.956648381403685 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 85 410 6475 26095 0.0129573170731707 0.0103626023740606 0.0159973206005963 0.984531220524429 0.982972387396802 0.985982469029288 0.171717171717171 0.139527710425145 0.207885995274272 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 1 0.835511818438647 0.652448808044578 1.05951966408091 NA NA NA NA NA NA 254 5) Not assoc w R Now listed Silent mutation no 0 +Ethambutol embB c.1608G>T embB_c.1608G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1614G>A embB_c.1614G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1617G>A embB_c.1617G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1632G>A embB_c.1632G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1638C>T embB_c.1638C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1641G>A embB_c.1641G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1644A>G embB_c.1644A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1647C>T embB_c.1647C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1648C>T embB_c.1648C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 5 3 9476 35702 0.000527370530534753 0.000171257241502832 0.00123027414547083 0.99991597815432 0.999754472342108 0.99998267234027 0.625 0.244863216366551 0.914766585862746 NA NA NA NA NA NA NA NA NA NA NA NA False False 6.27937244969748 1.22138615315282 40.4465543492688 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1656C>T embB_c.1656C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1659G>A embB_c.1659G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1674G>A embB_c.1674G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 10 9481 35695 0 0 0.00038900558066021 0.999719927181067 0.999484996631079 0.999865686288203 0 0 0.30849710781876 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.67996531074212 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 7 6560 26498 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.80327602229365 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1677G>C embB_c.1677G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1684C>A embB_c.1684C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1701C>T embB_c.1701C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.707313928675496 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1707A>G embB_c.1707A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1710G>A embB_c.1710G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.19822685561766 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.40943166615857 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1710G>T embB_c.1710G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1713G>A embB_c.1713G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1719G>A embB_c.1719G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1722G>T embB_c.1722G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1728C>G embB_c.1728C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 16 9481 35689 0 0 0.00038900558066021 0.999551883489707 0.999272388596077 0.99974384169233 0 0 0.205907214207822 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.976295497466411 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 15 6560 26490 0 0 0.000562171107654053 0.999434069043576 0.999066754461952 0.999683219243554 0 0 0.218019360910534 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.12620234951212 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1743C>T embB_c.1743C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1794G>A embB_c.1794G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1803C>T embB_c.1803C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 4 8 9477 35697 0.000421896424427802 0.000114964157806894 0.00107986688593449 0.999775941744853 0.999558563909973 0.999903262744512 0.333333333333333 0.0992460911495833 0.651124493581186 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.88334916112693 0.414922500512465 7.03130983507434 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 4 6 6556 26499 0.000609756097560975 0.000166162208307701 0.00156047520083291 0.99977362761743 0.99950734823901 0.999916920939814 0.4 0.121552258119827 0.737621923393055 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.69463087248322 0.559125120736519 11.3645694343848 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1809G>A embB_c.1809G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1830G>A embB_c.1830G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1839G>A embB_c.1839G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.183G>A embB_c.183G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1848A>G embB_c.1848A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1854G>C embB_c.1854G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1869C>T embB_c.1869C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.186G>C embB_c.186G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1881G>C embB_c.1881G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1884C>T embB_c.1884C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.707313928675496 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1887G>T embB_c.1887G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1890G>A embB_c.1890G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1894T>C embB_c.1894T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.88306962025316 0.0319145727646777 36.1783621216076 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1899C>T embB_c.1899C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1903C>T embB_c.1903C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1905G>C embB_c.1905G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 2 9479 35703 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999943985436213 0.999797670939776 0.99999321630447 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.76653655448887 0.272970929153834 51.9466713138689 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1912T>C embB_c.1912T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1926C>T embB_c.1926C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.192G>C embB_c.192G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1974C>T embB_c.1974C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1977G>A embB_c.1977G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1995G>A embB_c.1995G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 2 9479 35703 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999943985436213 0.999797670939776 0.99999321630447 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.76653655448887 0.272970929153834 51.9466713138689 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 2 2 6558 26503 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999924542539143 0.999727448570663 0.999990861620785 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.04132357426044 0.292866339798886 55.7129032982466 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.1995G>T embB_c.1995G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.201G>A embB_c.201G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.707313928675496 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.201G>T embB_c.201G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 9 9481 35696 0 0 0.00038900558066021 0.99974793446296 0.999521555266748 0.999884733314884 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.90786321657339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.40943166615857 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2040C>A embB_c.2040C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2056C>T embB_c.2056C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2076C>A embB_c.2076C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2079C>T embB_c.2079C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2103G>T embB_c.2103G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2109G>A embB_c.2109G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2118G>A embB_c.2118G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2124G>A embB_c.2124G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 2 9479 35703 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999943985436213 0.999797670939776 0.99999321630447 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.76653655448887 0.272970929153834 51.9466713138689 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 2 2 6558 26503 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999924542539143 0.999727448570663 0.999990861620785 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.04132357426044 0.292866339798886 55.7129032982466 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2145G>A embB_c.2145G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2151G>A embB_c.2151G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.10982832991351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.216C>T embB_c.216C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 9 9481 35696 0 0 0.00038900558066021 0.99974793446296 0.999521555266748 0.999884733314884 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.90786321657339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 9 6560 26496 0 0 0.000562171107654053 0.999660441426146 0.999355510362951 0.999844720818052 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.04691100627475 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2181G>A embB_c.2181G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 6 3 9475 35702 0.000632844636641704 0.000232277107744303 0.00137692358870305 0.99991597815432 0.999754472342108 0.99998267234027 0.666666666666666 0.29929505620854 0.925145368580308 NA NA NA NA NA NA NA NA NA NA NA NA False False 7.53604221635883 1.60899726455665 46.5481525523134 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 6 2 6554 26503 0.000914634146341463 0.000335726224038477 0.00198970246660848 0.999924542539143 0.999727448570663 0.999990861620785 0.75 0.349144205587175 0.968145973750055 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 12.1313701556301 2.1683237669748 123.038341532173 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2182C>A embB_c.2182C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2193G>A embB_c.2193G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 4 14 9477 35691 0.000421896424427802 0.000114964157806894 0.00107986688593449 0.999607898053494 0.999342206985133 0.999785618166341 0.222222222222222 0.0640920477176664 0.47637276573648 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.07601863157418 0.257834466158144 3.42722990821387 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 4 3 6556 26502 0.000609756097560975 0.000166162208307701 0.00156047520083291 0.999886813808715 0.999669257903365 0.999976657677988 0.571428571428571 0.184051567640083 0.901011721557492 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 5.38987187309335 0.911533096002148 36.799732538753 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2193G>C embB_c.2193G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2202C>T embB_c.2202C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2208C>T embB_c.2208C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2220G>T embB_c.2220G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2223G>T embB_c.2223G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 11 17 9470 35688 0.00116021516717645 0.00057931301275248 0.00207499495108562 0.999523876207814 0.999237788774316 0.999722616660517 0.392857142857142 0.215042829160961 0.594231793512436 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.4384620162743 1.03198956621968 5.52092453230596 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 2 3 6558 26502 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999886813808715 0.999669257903365 0.999976657677988 0.4 0.0527449505263169 0.853367200365326 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.69411405916437 0.224966079471659 23.5225659748306 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2226G>A embB_c.2226G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2226G>T embB_c.2226G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2235C>T embB_c.2235C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2245C>T embB_c.2245C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 14 9481 35691 0 0 0.00038900558066021 0.999607898053494 0.999342206985133 0.999785618166341 0 0 0.231635761650116 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.13511057396106 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 14 6560 26491 0 0 0.000562171107654053 0.999471797774004 0.999113925067086 0.999711197799087 0 0 0.231635761650116 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.21779664057642 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2247G>A embB_c.2247G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2250C>T embB_c.2250C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.707313928675496 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2256C>T embB_c.2256C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.19822685561766 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 6 6560 26499 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.43165838346939 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2265C>G embB_c.2265C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2265C>T embB_c.2265C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2268G>A embB_c.2268G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2289C>T embB_c.2289C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2298G>T embB_c.2298G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2325C>T embB_c.2325C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2328C>G embB_c.2328C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2329T>C embB_c.2329T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2338C>T embB_c.2338C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2340G>A embB_c.2340G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.19822685561766 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 6 6560 26499 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.43165838346939 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.234C>T embB_c.234C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2358C>T embB_c.2358C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2367G>A embB_c.2367G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.707313928675496 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2367G>C embB_c.2367G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2367G>T embB_c.2367G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.10982832991351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2379A>G embB_c.2379A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.237T>C embB_c.237T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2382G>T embB_c.2382G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2391G>C embB_c.2391G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.240C>A embB_c.240C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.707313928675496 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.240C>T embB_c.240C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 6 9480 35699 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99983195630864 0.999634275787128 0.999938328510354 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.627619549929676 0.0136468000350686 5.17448319653473 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 4 6559 26501 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999849085078287 0.999613643356053 0.999958879281354 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.01010062509528 0.0205075656450505 10.2127021503241 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2427C>A embB_c.2427C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2427C>G embB_c.2427C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2433C>T embB_c.2433C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2442C>T embB_c.2442C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2463G>A embB_c.2463G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2475C>A embB_c.2475C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2481T>C embB_c.2481T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2487T>G embB_c.2487T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 6 23 9475 35682 0.000632844636641704 0.000232277107744303 0.00137692358870305 0.999355832516454 0.999033588308985 0.99959161063274 0.206896551724137 0.0799418488760801 0.397246949227239 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.982411380061948 0.327116797523547 2.4827738360382 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 4 19 6556 26486 0.000609756097560975 0.000166162208307701 0.00156047520083291 0.999283154121863 0.998880781714398 0.999568358524102 0.17391304347826 0.0495076453057934 0.387811889954797 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.85051860890787 0.210357511011003 2.56057334428735 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2490G>A embB_c.2490G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2496G>A embB_c.2496G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.88306962025316 0.0319145727646777 36.1783621216076 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2499G>A embB_c.2499G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 168 9479 35537 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.995294776641926 0.994529113960534 0.995978065869475 0.0117647058823529 0.00142794952288728 0.041850090291834 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.0446312399841253 0.00537292002656144 0.163815640275932 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 1 149 6559 26356 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.994378419166195 0.993403073007904 0.995242834765129 0.00666666666666666 0.000168771143109947 0.0365831677405802 NA NA NA NA NA NA NA NA NA NA NA NA False True 1 1 1 0 0 0 0 0.0269684259857094 0.000682685427016037 0.152668020044803 NA NA NA NA NA NA 17 5) Not assoc w R Now listed Silent mutation no 0 +Ethambutol embB c.249G>A embB_c.249G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2505T>C embB_c.2505T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.19822685561766 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2511C>T embB_c.2511C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2514T>C embB_c.2514T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2520C>T embB_c.2520C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2523G>T embB_c.2523G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2535A>G embB_c.2535A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2538C>A embB_c.2538C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2550C>T embB_c.2550C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 5 20 9476 35685 0.000527370530534753 0.000171257241502832 0.00123027414547083 0.999439854362134 0.999135032404509 0.999657815983264 0.2 0.068311464012484 0.407037432278677 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.941457365977205 0.27603251944769 2.58578295319993 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 4 18 6556 26487 0.000609756097560975 0.000166162208307701 0.00156047520083291 0.999320882852292 0.998926913664084 0.999597464048431 0.181818181818181 0.0518672993124368 0.402845783077871 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.897803538743136 0.22093985235092 2.72689584865821 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2556A>G embB_c.2556A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2565G>A embB_c.2565G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.10982832991351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.40943166615857 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2580G>A embB_c.2580G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2583G>A embB_c.2583G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2598T>G embB_c.2598T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2610C>T embB_c.2610C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.261G>A embB_c.261G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2631G>A embB_c.2631G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2631G>T embB_c.2631G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2679C>T embB_c.2679C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 7 9481 35698 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.61285174975179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 6 6560 26499 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.43165838346939 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2682C>A embB_c.2682C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 118 9477 35587 0.000421896424427802 0.000114964157806894 0.00107986688593449 0.996695140736591 0.996043541042457 0.99726373945935 0.0327868852459016 0.0090042171751531 0.0818207264337929 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.127291229613891 0.0340958387248986 0.334759964796106 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 4 106 6556 26399 0.000609756097560975 0.000166162208307701 0.00156047520083291 0.996000754574608 0.995165055294048 0.996724618977081 0.0363636363636363 0.00999520434410411 0.0904920499652015 NA NA NA NA NA NA NA NA NA NA NA NA False True 1 1 1 0 0 0 0 0.151950683228383 0.0406408547278573 0.400876878265256 NA NA NA NA NA NA 12 5) Not assoc w R Now listed Silent mutation no 0 +Ethambutol embB c.2682C>T embB_c.2682C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2709C>G embB_c.2709C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2709C>T embB_c.2709C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2715G>C embB_c.2715G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2718A>G embB_c.2718A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2739C>A embB_c.2739C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.76624472573839 0.0479745002090283 294.932792118969 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2739C>T embB_c.2739C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2745G>C embB_c.2745G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 2 9479 35703 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999943985436213 0.999797670939776 0.99999321630447 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.76653655448887 0.272970929153834 51.9466713138689 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 2 2 6558 26503 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999924542539143 0.999727448570663 0.999990861620785 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.04132357426044 0.292866339798886 55.7129032982466 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2745G>T embB_c.2745G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 7 9481 35698 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.61285174975179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2751G>A embB_c.2751G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2772G>A embB_c.2772G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2814G>A embB_c.2814G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2835G>A embB_c.2835G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 3 9480 35702 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99991597815432 0.999754472342108 0.99998267234027 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.25534458509142 0.0239099774609589 15.6346568618898 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2839C>A embB_c.2839C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2841G>A embB_c.2841G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2841G>C embB_c.2841G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 11 68 9470 35637 0.00116021516717645 0.00057931301275248 0.00207499495108562 0.998095504831256 0.997586214304378 0.998520790809246 0.139240506329113 0.0716104720590858 0.235496552189972 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.608744331946083 0.290151342604959 1.15979757793765 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 11 59 6549 26446 0.00167682926829268 0.000837354988859942 0.00299832542833478 0.997774004904735 0.997129555363513 0.998305050762254 0.157142857142857 0.0811437635504477 0.263799765216311 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.752879854862043 0.356435262128536 1.44802951192263 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2847G>A embB_c.2847G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2853G>A embB_c.2853G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2859G>A embB_c.2859G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2871G>A embB_c.2871G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.10982832991351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2889G>C embB_c.2889G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2895G>A embB_c.2895G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 266 1761 9215 33944 0.0280561122244488 0.0248250573791418 0.0315812786547065 0.950679176585912 0.94838220992595 0.952902478094097 0.131228416378885 0.116824052092932 0.146708363842983 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.556403636640381 0.486255500535436 0.634692112002786 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 156 1337 6404 25168 0.023780487804878 0.0202301187892821 0.0277623707516845 0.949556687417468 0.946853327796864 0.952160941337365 0.104487608841259 0.0894261005679239 0.121124426937957 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 1 0.458554091800328 0.385100094407895 0.542967426133478 NA NA NA NA NA NA 242 5) Not assoc w R Now listed Silent mutation no 0 +Ethambutol embB c.2922G>C embB_c.2922G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2928A>G embB_c.2928A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 3 10 9478 35695 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999719927181067 0.999484996631079 0.999865686288203 0.23076923076923 0.0503810734911515 0.53813153923404 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.1298269677147 0.199764717731683 4.38926258928456 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 3 10 6557 26495 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 0.999622712695717 0.999306265033238 0.999819061720012 0.23076923076923 0.0503810734911515 0.53813153923404 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.21221595241726 0.214314396732616 4.70983259529179 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2934G>A embB_c.2934G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 22 9481 35683 0 0 0.00038900558066021 0.999383839798347 0.999067273782758 0.999613816670924 0 0 0.154372512815574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.687231530422914 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 22 6560 26483 0 0 0.000562171107654053 0.999169967930579 0.998743589564863 0.99947975252246 0 0 0.154372512815574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.737212705059962 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2937C>T embB_c.2937C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2940G>A embB_c.2940G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2946G>A embB_c.2946G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2955G>C embB_c.2955G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2956C>T embB_c.2956C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2967G>A embB_c.2967G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2979C>T embB_c.2979C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.297G>A embB_c.297G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2982C>T embB_c.2982C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 5 2 9476 35703 0.000527370530534753 0.000171257241502832 0.00123027414547083 0.999943985436213 0.999797670939776 0.99999321630447 0.714285714285714 0.290420863737342 0.963307433823914 NA NA NA NA NA NA NA NA NA NA NA NA False False 9.4193224989447 1.54161474423025 98.9467001652174 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 5 2 6555 26503 0.000762195121951219 0.000247527523788107 0.00177780526826415 0.999924542539143 0.999727448570663 0.999990861620785 0.714285714285714 0.290420863737342 0.963307433823914 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 10.1079328756674 1.6542054319611 106.199585900179 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2985G>A embB_c.2985G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.19822685561766 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2985G>T embB_c.2985G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.2994G>A embB_c.2994G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.3009C>T embB_c.3009C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.300C>A embB_c.300C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.3012T>C embB_c.3012T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.3015C>T embB_c.3015C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.3021C>T embB_c.3021C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.3036C>T embB_c.3036C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.3039C>T embB_c.3039C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.303C>A embB_c.303C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.3048G>C embB_c.3048G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.306A>C embB_c.306A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.306A>G embB_c.306A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.3078C>T embB_c.3078C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.3081G>A embB_c.3081G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 274 526 9207 35179 0.0288999050733045 0.0256204347372978 0.0324728763257743 0.985268169724128 0.983964272631465 0.986492234142652 0.3425 0.309623266066151 0.376542694125519 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.99035326485344 1.71050329396773 2.31196461497274 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 266 477 6294 26028 0.0405487804878048 0.0359047821577357 0.0456066252201096 0.982003395585738 0.980330214979928 0.983569678185189 0.358008075370121 0.323485523104141 0.39366300392015 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.30609565264312 1.97224943467233 2.69204444920153 NA NA NA NA NA NA 172 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.3093C>T embB_c.3093C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.3096T>G embB_c.3096T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.3099C>T embB_c.3099C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.309C>T embB_c.309C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.3123C>T embB_c.3123C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.76624472573839 0.0479745002090283 294.932792118969 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.3127T>C embB_c.3127T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.3133C>A embB_c.3133C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.3144C>T embB_c.3144C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.3156C>T embB_c.3156C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.3159G>A embB_c.3159G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.3159G>C embB_c.3159G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.3165C>A embB_c.3165C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 38 59 9443 35646 0.00400801603206412 0.00283782488513525 0.00549720571138138 0.998347570368295 0.997868996876833 0.998741863354622 0.391752577319587 0.294176123651029 0.496124922775975 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.43126555945844 1.5722133237436 3.71901381926898 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 10 31 6550 26474 0.00152439024390243 0.000731238785140689 0.00280161526425175 0.998830409356725 0.99834026667881 0.999205185871022 0.24390243902439 0.123632488395844 0.40304623662365 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.30381679389312 0.569882190636909 2.73062269591158 NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.3177C>A embB_c.3177C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.3186T>C embB_c.3186T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.318C>T embB_c.318C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.3208C>T embB_c.3208C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.3210G>A embB_c.3210G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.3219C>G embB_c.3219C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 36 464 9445 35241 0.00379706781985022 0.00266079394079502 0.00525290420804873 0.987004621201512 0.985775438829593 0.988153611356761 0.072 0.0509343331251329 0.0982874373368569 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.289488143699457 0.200086525373208 0.407091647617028 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 32 350 6528 26155 0.0048780487804878 0.00333890307856758 0.0068794310839757 0.986794944350122 0.985347161591816 0.988134496866097 0.0837696335078534 0.0580029915914511 0.116200335015005 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 1 0.366316526610644 0.246452975098726 0.527430894047878 NA NA NA NA NA NA 20 5) Not assoc w R Now listed Silent mutation no 0 +Ethambutol embB c.3225C>A embB_c.3225C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 3 6 9478 35699 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.99983195630864 0.999634275787128 0.999938328510354 0.333333333333333 0.0748546314196918 0.700704943791459 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.88325596117324 0.304716275204421 8.82053669197219 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 2 6 6558 26499 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.99977362761743 0.99950734823901 0.999916920939814 0.25 0.0318540262499442 0.650855794412824 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.34690454406831 0.132947871900757 7.53464906456895 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.3231G>A embB_c.3231G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.3240G>A embB_c.3240G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.3243C>A embB_c.3243C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.3252C>A embB_c.3252C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.3255C>T embB_c.3255C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.3273G>T embB_c.3273G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 6 9480 35699 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99983195630864 0.999634275787128 0.999938328510354 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.627619549929676 0.0136468000350686 5.17448319653473 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 6 6559 26499 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.99977362761743 0.99950734823901 0.999916920939814 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.673349595974996 0.0146401601947477 5.55241977196973 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.3297G>A embB_c.3297G>A 1 stop_retained_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.330T>C embB_c.330T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.333G>A embB_c.333G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.336G>A embB_c.336G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.340T>C embB_c.340T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.342G>A embB_c.342G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.351C>T embB_c.351C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 8 342 9473 35363 0.000843792848855605 0.000364358012393849 0.00166192766222289 0.990421509592494 0.989356316812908 0.991405745890591 0.0228571428571428 0.0099185546559046 0.044539273600113 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.0873223559973158 0.0373851437490693 0.174109235396807 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 7 315 6553 26190 0.0010670731707317 0.000429122972600259 0.00219733487653492 0.98811544991511 0.986737080364429 0.989385193694144 0.0217391304347826 0.00878388340039016 0.0442760616671092 NA NA NA NA NA NA NA NA NA NA NA NA False True 1 1 1 0 0 0 1 0.0888142835342591 0.035397917632443 0.185289865628524 NA NA NA NA NA NA 30 5) Not assoc w R Now listed Silent mutation no 0 +Ethambutol embB c.375C>T embB_c.375C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.390G>A embB_c.390G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.390G>C embB_c.390G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.39T>C embB_c.39T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.408G>A embB_c.408G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.408G>T embB_c.408G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.423G>A embB_c.423G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.429G>C embB_c.429G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.456T>C embB_c.456T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.456T>G embB_c.456T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.707313928675496 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.459C>G embB_c.459C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.462C>T embB_c.462C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.465C>A embB_c.465C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.471C>T embB_c.471C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 2 9479 35703 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999943985436213 0.999797670939776 0.99999321630447 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.76653655448887 0.272970929153834 51.9466713138689 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.486C>T embB_c.486C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.489G>C embB_c.489G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.48T>A embB_c.48T>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 9478 35705 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 1 0.999896689850119 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.55639137151076 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 6557 26505 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 1 0.999860832946126 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.66990152933523 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.495G>A embB_c.495G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 22 9481 35683 0 0 0.00038900558066021 0.999383839798347 0.999067273782758 0.999613816670924 0 0 0.154372512815574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.687231530422914 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 21 6560 26484 0 0 0.000562171107654053 0.999207696661007 0.998789133813842 0.999509486956307 0 0 0.161097615219079 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.775545077245766 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.501G>T embB_c.501G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.504G>A embB_c.504G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.507C>T embB_c.507C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.514C>T embB_c.514C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.516G>A embB_c.516G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.525C>T embB_c.525C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.531C>T embB_c.531C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.537C>T embB_c.537C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 18 9481 35687 0 0 0.00038900558066021 0.99949586892592 0.999203372130377 0.999701193476901 0 0 0.185301968137852 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.856331153965207 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 14 6560 26491 0 0 0.000562171107654053 0.999471797774004 0.999113925067086 0.999711197799087 0 0 0.231635761650116 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.21779664057642 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.54G>A embB_c.54G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.54G>T embB_c.54G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 6 103 9475 35602 0.000632844636641704 0.000232277107744303 0.00137692358870305 0.99711524996499 0.996502475948288 0.997644781837702 0.055045871559633 0.0204662237768234 0.115966531409054 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.218881573891436 0.0784821963275573 0.493119489210752 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 3 45 6557 26460 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 0.99830220713073 0.997728871689333 0.998761356977428 0.0625 0.0130792444095526 0.17195993079057 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.269025468964465 0.0534702173818359 0.838470772293996 NA NA NA NA NA NA 25 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.555T>C embB_c.555T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.573C>T embB_c.573C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA 12 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.588G>A embB_c.588G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.10982832991351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.591G>A embB_c.591G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.606C>A embB_c.606C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.606C>T embB_c.606C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.60T>C embB_c.60T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.615C>T embB_c.615C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.639G>A embB_c.639G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.63G>T embB_c.63G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.645C>T embB_c.645C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.648G>C embB_c.648G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 7 9481 35698 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.61285174975179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 7 6560 26498 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.80327602229365 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.648G>T embB_c.648G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.655C>T embB_c.655C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.660G>A embB_c.660G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 92 9477 35613 0.000421896424427802 0.000114964157806894 0.00107986688593449 0.997423330065817 0.996840865225292 0.997922350269659 0.0416666666666666 0.0114676891661322 0.103257444449818 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.163384119905859 0.0435841884572166 0.432887261555349 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 4 82 6556 26423 0.000609756097560975 0.000166162208307701 0.00156047520083291 0.996906244104885 0.996161267083087 0.997538710799856 0.0465116279069767 0.0128163524215735 0.114825497538114 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 0 1 0 0 0 1 0.196602628015297 0.0522818699403131 0.523138003307163 NA NA NA NA NA NA 6 Literature evidence (PMID 32143680) 4) Not assoc w R - Interim Now listed Silent mutation no Lit. (PMID 32143680) 0 +Ethambutol embB c.669C>T embB_c.669C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.684C>G embB_c.684C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.684C>T embB_c.684C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.690C>T embB_c.690C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.693C>A embB_c.693C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.696A>G embB_c.696A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 5 9480 35700 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999859963590533 0.999673232250017 0.999954529045718 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.753164556962025 0.0159260191955521 6.73154939272228 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 5 6559 26500 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999811356347858 0.999559824020536 0.9999387451734 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.808050007623113 0.0170817619606711 7.22310074751644 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.714C>T embB_c.714C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.715C>T embB_c.715C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.724T>C embB_c.724T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.726G>A embB_c.726G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.72C>G embB_c.72C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.732G>A embB_c.732G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.741A>G embB_c.741A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.756C>G embB_c.756C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.765G>A embB_c.765G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.771G>C embB_c.771G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.780G>C embB_c.780G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.783G>A embB_c.783G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.19822685561766 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 6 6560 26499 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.43165838346939 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.783G>T embB_c.783G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.78G>A embB_c.78G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.78G>C embB_c.78G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.799C>A embB_c.799C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.834G>T embB_c.834G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.10982832991351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.843C>T embB_c.843C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.846G>A embB_c.846G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.849G>A embB_c.849G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.855C>T embB_c.855C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.861C>T embB_c.861C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.87G>C embB_c.87G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.882C>T embB_c.882C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 3 26 9478 35679 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999271810670774 0.99893321465683 0.999524269143814 0.103448275862068 0.0218637368298536 0.273515197892423 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.434354050676059 0.0841243884189175 1.41774609092159 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 3 19 6557 26486 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 0.999283154121863 0.998880781714398 0.999568358524102 0.136363636363636 0.0290558511287467 0.349122097257408 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.637791673021198 0.12084377268908 2.16762546304177 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.894G>A embB_c.894G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.906C>T embB_c.906C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.910C>T embB_c.910C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.924A>G embB_c.924A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.93C>G embB_c.93C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.945C>T embB_c.945C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.990C>T embB_c.990C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB c.993C>T embB_c.993C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embB p.Ala1007Thr embB_p.Ala1007Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3498 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2882 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala1007Val embB_p.Ala1007Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3681 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3036 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala1020Ser embB_p.Ala1020Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Ala102Thr embB_p.Ala102Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala102Val embB_p.Ala102Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala1058Val embB_p.Ala1058Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala1073Asp embB_p.Ala1073Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 27 1 26 1 26 9480 35679 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999271810670774 0.99893321465683 0.999524269143814 0.037037037037037 0.000937257091944708 0.189705617413044 0.037037037037037 0.000937257091944708 0.189705617413044 0.037037037037037 0.000937257091944708 0.189705617413044 0.144754138266796 0.00353417643782867 0.881399653446109 0.0297748013230228 72 4975 False False 0.144754138266796 0.00353417643782867 0.881399653446109 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999271810670774 0.99893321465683 0.999524269143814 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 14 0 14 0 14 6560 26491 0 0 0.000562171107654053 0.999471797774004 0.999113925067086 0.999711197799087 0 0 0.231635761650116 0 0 0.231635761650116 0 0 0.231635761650116 0 0 1.21779664057642 0.0874873937321629 91 4087 False False 0 0 0 0 0 0 0 0 0 1.21779664057642 0 0 0.000562171107654053 0.999471797774004 0.999113925067086 0.999711197799087 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala1073Gly embB_p.Ala1073Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3596 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2966 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Ala1073Val embB_p.Ala1073Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala1076Thr embB_p.Ala1076Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala1083Glu embB_p.Ala1083Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Ala1083Thr embB_p.Ala1083Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Ala1083Val embB_p.Ala1083Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3630 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2991 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala109Thr embB_p.Ala109Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3549 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala113Thr embB_p.Ala113Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala155Pro embB_p.Ala155Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12104088004766 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala155Thr embB_p.Ala155Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3569 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2947 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Ala155Val embB_p.Ala155Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala15Pro embB_p.Ala15Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3631 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2992 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala196Thr embB_p.Ala196Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 146.529978407112 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 157.179059039538 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala201Glu embB_p.Ala201Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala201Ser embB_p.Ala201Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3591 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala201Thr embB_p.Ala201Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala204Thr embB_p.Ala204Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala21Thr embB_p.Ala21Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Ala221Ser embB_p.Ala221Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3674 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala221Thr embB_p.Ala221Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala225Glu embB_p.Ala225Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala225Thr embB_p.Ala225Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3543 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Ala228Thr embB_p.Ala228Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12104088004766 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala232Glu embB_p.Ala232Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala232Thr embB_p.Ala232Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala235Val embB_p.Ala235Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala249Asp embB_p.Ala249Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3518 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2902 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Ala259Glu embB_p.Ala259Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3675 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3031 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Ala259Val embB_p.Ala259Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala271Thr embB_p.Ala271Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala281Val embB_p.Ala281Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3616 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2978 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala295Val embB_p.Ala295Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala30Thr embB_p.Ala30Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 3 3 9478 35702 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.99991597815432 0.999754472342108 0.99998267234027 0.5 0.118117248757025 0.881882751242974 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11841471655 1 2818.5 4975 False False 3.76682844481958 0.504418797674528 28.1425087484132 0 0 0.000389128685709026 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 6557 26505 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 1 0.999860832946126 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2883 4087 False False 0 0 0 0 0 0 0 Inf 1.66990152933523 Inf 0 0 0.000562428243381166 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala313Thr embB_p.Ala313Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala313Val embB_p.Ala313Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 0 11 9481 35694 0 0 0.00038900558066021 0.999691919899173 0.999448826618347 0.999846197812 0 0 0.284914152918154 0 0 0.369416647552819 0 0 0.284914152918154 0 0 2.20605564927831 0.217673629700269 220.5 4975 False False 0 0 1.50034693324555 0 0 0.00038900558066021 0.999691919899173 0.999448826618347 0.999846197812 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 8 6560 26497 0 0 0.000562171107654053 0.999698170156574 0.999405361976814 0.999869682578628 0 0 0.369416647552819 0 0 0.4592581264399 0 0 0.369416647552819 0 0 3.43139939855491 0.605987594467308 325 4087 False False 0 0 0 0 0 0 0 0 0 2.36695385477914 0 0 0.000562171107654053 0.999698170156574 0.999405361976814 0.999869682578628 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala338Thr embB_p.Ala338Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 24 0 24 5 30 9476 35675 0.000527370530534753 0.000171257241502832 0.00123027414547083 0.999159781543201 0.998800751376515 0.999433038579865 0.142857142857142 0.0480607784036389 0.302571351690951 0 0 0.142473597722525 0 0 0.115703308222027 0 0 0.625660502189983 0.00502753185912536 44 4975 False False 0.627462361052483 0.19002483904318 1.63393056425105 0 0 0.000389210799037296 0.999159781543201 0.998800751376515 0.999433038579865 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 21 0 21 5 27 6555 26478 0.000762195121951219 0.000247527523788107 0.00177780526826415 0.998981324278438 0.998518223777074 0.999328582311798 0.15625 0.0527505644021341 0.327878765682041 0 0 0.161097615219079 0 0 0.127702867615432 0 0 0.775960973077721 0.0134316563695534 46 4087 False False 0 0 0 0 0 0 0 0.748029494024917 0.224845930971873 1.97151999635342 0 0 0.00056259979792051 0.998981324278438 0.998518223777074 0.999328582311798 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala33Pro embB_p.Ala33Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Ala356Val embB_p.Ala356Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala357del embB_p.Ala357del 1 inframe_deletion (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3580 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2953 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Ala357Thr embB_p.Ala357Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala376Thr embB_p.Ala376Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3682 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala379Thr embB_p.Ala379Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala379Val embB_p.Ala379Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 146.529978407112 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 157.179059039538 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala383Ser embB_p.Ala383Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Ala386Glu embB_p.Ala386Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.10982832991351 0.590980565810755 492 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala386Ser embB_p.Ala386Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3559 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2938 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Ala386Thr embB_p.Ala386Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Ala386Val embB_p.Ala386Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Ala388Asp embB_p.Ala388Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala388Ser embB_p.Ala388Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3607 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Ala388Val embB_p.Ala388Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala409Pro embB_p.Ala409Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 36 2 9445 35703 0.00379706781985022 0.00266079394079502 0.00525290420804873 0.999943985436213 0.999797670939776 0.99999321630447 0.947368421052631 0.822509409652359 0.993561283284908 0.5 0.012579117093425 0.987420882906574 0.333333333333333 0.00840375865961264 0.905700675949754 3.78009528851244 0.0481509106779564 296.014587695196 0.374660742735257 324 4975 False False 68.0417151932239 17.5104444651931 582.499255456984 0.000105864916366716 2.68026403293136e-06 0.000589698846634798 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 31 2 6529 26503 0.00472560975609756 0.00321301337622354 0.00670097545873859 0.999924542539143 0.999727448570663 0.999990861620785 0.939393939393939 0.797735687473645 0.99257416225774 0.5 0.012579117093425 0.987420882906574 0.333333333333333 0.00840375865961264 0.905700675949754 4.05927400827079 0.0517046754622252 317.818168600981 0.356279592355921 183 4087 False False 0 0 0 0 0 0 0 62.9187471281972 15.9951937530598 541.898766278448 0.000153139356814701 3.87714531452494e-06 0.000852939269919986 0.999924542539143 0.999727448570663 0.999990861620785 16 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala431Pro embB_p.Ala431Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala432Val embB_p.Ala432Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Ala438Thr embB_p.Ala438Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala439Gly embB_p.Ala439Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3560 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2939 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala439Thr embB_p.Ala439Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3666 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3024 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Ala439Val embB_p.Ala439Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala43Thr embB_p.Ala43Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3499 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2884 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Ala43Val embB_p.Ala43Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Ala451Thr embB_p.Ala451Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala454Pro embB_p.Ala454Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala454Thr embB_p.Ala454Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 6 6 9475 35699 0.000632844636641704 0.000232277107744303 0.00137692358870305 0.99983195630864 0.999634275787128 0.999938328510354 0.5 0.210944638239296 0.789055361760703 0 0 0.707598226178713 0 0 0.4592581264399 0 0 9.12053514227336 1 2818.5 4975 False False 3.76770448548812 1.00696556191593 14.0966097383566 0 0 0.000389251868698371 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 2 4 6558 26501 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999849085078287 0.999613643356053 0.999958879281354 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.841886116991581 0 0 0.602364635616474 0 0 21.5230740827793 1 2276.5 4087 False False 0 0 0 0 0 0 0 2.02050930161634 0.182720640564327 14.1017085588021 0 0 0.00056234250533983 0.999849085078287 0.999613643356053 0.999958879281354 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala457Thr embB_p.Ala457Thr 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3010 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala484Thr embB_p.Ala484Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala485Val embB_p.Ala485Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala495Thr embB_p.Ala495Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala505Pro embB_p.Ala505Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Ala505Thr embB_p.Ala505Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Ala505Val embB_p.Ala505Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 4 4 9477 35701 0.000421896424427802 0.000114964157806894 0.00107986688593449 0.999887970872426 0.999713186009257 0.999969475016731 0.5 0.157012770487058 0.842987229512941 0.333333333333333 0.00840375865961264 0.905700675949754 0.2 0.00505076337946806 0.716417936118089 1.88356019837501 0.0319228861367252 36.1878598574281 0.506554767776731 350 4975 False False 3.76712039675002 0.701511118396156 20.2258787305262 0.000105507491031863 2.67121483114821e-06 0.000587708362116832 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 4 1 6556 26504 0.000609756097560975 0.000166162208307701 0.00156047520083291 0.999962271269571 0.999789807096406 0.999999044791703 0.8 0.28358206388191 0.994949236620532 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.103643319688456 Inf 0.198330359033302 124.5 4087 False False 0 0 0 0 0 0 0 16.1708358755338 1.59970034177407 792.771744020614 0.000152508769254232 3.86118028152325e-06 0.000849428314837321 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala510Thr embB_p.Ala510Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.841886116991581 0 0 0.521823750104981 0 0 20.0577749283512 1 2818.5 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.841886116991581 0 0 0.521823750104981 0 0 21.5157135377061 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala517Thr embB_p.Ala517Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala547Ser embB_p.Ala547Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.10982832991351 0.590980565810755 492 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12104088004766 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala54Thr embB_p.Ala54Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Ala553Thr embB_p.Ala553Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala567Asp embB_p.Ala567Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3721 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3071 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala567Thr embB_p.Ala567Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala571Thr embB_p.Ala571Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala571Val embB_p.Ala571Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 2 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Ala5Ser embB_p.Ala5Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3707 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3058 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Ala5Thr embB_p.Ala5Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3642 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3002 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala601Gly embB_p.Ala601Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3659 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3018 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala601Pro embB_p.Ala601Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3581 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2954 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala607Asp embB_p.Ala607Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3687 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3041 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Ala608Thr embB_p.Ala608Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala627Val embB_p.Ala627Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3561 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2940 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala630Thr embB_p.Ala630Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala677Glu embB_p.Ala677Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala679Ser embB_p.Ala679Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3667 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Ala679Thr embB_p.Ala679Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 1 11 9480 35694 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999691919899173 0.999448826618347 0.999846197812 0.0833333333333333 0.00210759323186022 0.384796165150944 0 0 0.369416647552819 0 0 0.284914152918154 0 0 2.20628852716039 0.217682902129337 231 4975 False False 0.34228998849252 0.00795492252872522 2.35571643249047 0 0 0.00038904660702099 0.999691919899173 0.999448826618347 0.999846197812 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 1 5 6559 26500 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999811356347858 0.999559824020536 0.9999387451734 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.602364635616474 0 0 0.521823750104981 0 0 6.1217432561314 1 2276.5 4087 False False 0 0 0 0 0 0 0 0.808050007623113 0.0170817619606711 7.22310074751644 0 0 0.000562256793434776 0.999811356347858 0.999559824020536 0.9999387451734 2 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala679Val embB_p.Ala679Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3519 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2903 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala680Thr embB_p.Ala680Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 1 5 9480 35700 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999859963590533 0.999673232250017 0.999954529045718 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.602364635616474 0 0 0.521823750104981 0 0 5.70559538331064 0.585903624207148 445 4975 False False 0.753164556962025 0.0159260191955521 6.73154939272228 0 0 0.00038904660702099 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 157.208880998325 1 2276.5 4087 False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 0 0 0.000562256793434776 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala683Val embB_p.Ala683Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3651 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3011 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala684Thr embB_p.Ala684Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 20.058335224773 1 1480 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 21.5165239024995 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala684Val embB_p.Ala684Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala693Thr embB_p.Ala693Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala701Pro embB_p.Ala701Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3660 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala701Thr embB_p.Ala701Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala705Thr embB_p.Ala705Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala716Pro embB_p.Ala716Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3637 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2997 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Ala716Val embB_p.Ala716Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Ala720Val embB_p.Ala720Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala724Thr embB_p.Ala724Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3701 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Ala724Val embB_p.Ala724Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3529 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2912 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala761Val embB_p.Ala761Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala799Thr embB_p.Ala799Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala801Glu embB_p.Ala801Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Ala801Thr embB_p.Ala801Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala840Gly embB_p.Ala840Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala840Pro embB_p.Ala840Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala840Val embB_p.Ala840Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala852Val embB_p.Ala852Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala861Thr embB_p.Ala861Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala880Thr embB_p.Ala880Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3643 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3003 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Ala903Thr embB_p.Ala903Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala909Thr embB_p.Ala909Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3534 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2917 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala90Gly embB_p.Ala90Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Ala928Thr embB_p.Ala928Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Ala941Thr embB_p.Ala941Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3661 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3019 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala943Val embB_p.Ala943Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala945Thr embB_p.Ala945Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Ala94Val embB_p.Ala94Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala950Val embB_p.Ala950Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ala993Thr embB_p.Ala993Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Arg1045Gln embB_p.Arg1045Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Arg1055His embB_p.Arg1055His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Arg1059Gly embB_p.Arg1059Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Arg1059Pro embB_p.Arg1059Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Arg122His embB_p.Arg122His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Arg147Cys embB_p.Arg147Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Arg147His embB_p.Arg147His 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3662 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3020 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Arg14Gln embB_p.Arg14Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 1 3 8 7 9473 35698 0.000843792848855605 0.000364358012393849 0.00166192766222289 0.999803949026747 0.999596102051779 0.999921173824063 0.533333333333333 0.265861347277396 0.787333270480692 0.25 0.00630946320970987 0.805879550316756 0.125 0.0031597235312519 0.526509670875206 1.25613146134628 0.02392496296889 15.6444591978668 1 2818.5 4975 False False 4.30673643890154 1.36419476054254 13.9554141922868 0.000105552037154317 2.67234263830968e-06 0.000587956437510075 0.999803949026747 0.999596102051779 0.999921173824063 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 1 3 8 7 6552 26498 0.00121951219512195 0.000526641184096925 0.00240150352406598 0.999735898887002 0.999455926960675 0.999893811273379 0.533333333333333 0.265861347277396 0.787333270480692 0.25 0.00630946320970987 0.805879550316756 0.125 0.0031597235312519 0.526509670875206 1.34808709808709 0.0256752145718854 16.7907584145303 0.586825545542005 247 4087 False False 0 0 0 0 0 0 0 4.62201290772719 1.46391085206005 14.9789449405235 0.000152601861742713 3.86353717016821e-06 0.000849946631353037 0.999735898887002 0.999455926960675 0.999893811273379 2 3) Uncertain significance No change no 1 +Ethambutol embB p.Arg173Leu embB_p.Arg173Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3644 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3004 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Arg173Pro embB_p.Arg173Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Arg182Cys embB_p.Arg182Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 157.21479794295 1 1103 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Arg213Gln embB_p.Arg213Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 201 0 201 1 209 9480 35496 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.994146478084302 0.993299656822992 0.994911327786654 0.00476190476190476 0.000120553723217226 0.0262446357302904 0 0 0.0181852500543862 0 0 0.0174952895791865 0 0 0.0693465663210882 4.83643546478043e-21 NA NA False True 0.0179153291744897 0.000456212935301003 0.100937062660081 0 0 0.00038904660702099 0.994146478084302 0.993299656822992 0.994911327786654 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 200 0 200 1 207 6559 26298 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.992190152801358 0.991055779487027 0.993214526231697 0.0048076923076923 0.000121712823086976 0.0264942193528228 0 0 0.0182753403551362 0 0 0.0176628245362134 0 0 0.0746871032464529 7.26282761553959e-20 NA NA False True 1 1 1 0 0 1 0 0.0193693365239929 0.000492733765429556 0.109161177469203 0 0 0.000562256793434776 0.992190152801358 0.991055779487027 0.993214526231697 8 Not assoc w R 5) Not assoc w R No change yes 1 +Ethambutol embB p.Arg213Trp embB_p.Arg213Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Arg238His embB_p.Arg238His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Arg257Gln embB_p.Arg257Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Arg257Trp embB_p.Arg257Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Arg267Gln embB_p.Arg267Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0615661524565 1 2818.5 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.5214194708504 1 2276.5 4087 False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 0 0 0.000562256793434776 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Arg267Pro embB_p.Arg267Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 9 9481 35696 0 0 0.00038900558066021 0.99974793446296 0.999521555266748 0.999884733314884 0 0 0.336267116879942 0 0 0.409616397225003 0 0 0.336267116879942 0 0 2.61270538046685 0.357639787175474 320 4975 False False 0 0 1.90786321657339 0 0 0.00038900558066021 0.99974793446296 0.999521555266748 0.999884733314884 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 6 6560 26499 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 0 0 0.4592581264399 0 0 0.602364635616474 0 0 0.4592581264399 0 0 6.12057895719864 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 3.43165838346939 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Arg351Cys embB_p.Arg351Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.707313928675496 Inf 0.0440214455254381 88.5 4975 False False Inf 0.707313928675496 Inf 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.758877818966333 Inf 0.0393565980154275 66.5 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Arg351His embB_p.Arg351His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3601 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Arg367His embB_p.Arg367His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Arg372Cys embB_p.Arg372Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Arg464Gln embB_p.Arg464Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Arg464Leu embB_p.Arg464Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Arg468His embB_p.Arg468His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Arg469His embB_p.Arg469His 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Arg507Thr embB_p.Arg507Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3592 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2963 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Arg524His embB_p.Arg524His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 4 2 9477 35703 0.000421896424427802 0.000114964157806894 0.00107986688593449 0.999943985436213 0.999797670939776 0.99999321630447 0.666666666666666 0.222778095503512 0.956728131707258 1 0.025 1 0.333333333333333 0.00840375865961264 0.905700675949754 Inf 0.0965879675413201 Inf 0.209778446692193 170 4975 False False 7.5346628679962 1.07960939031162 83.5007416994224 0.000105507491031863 2.67121483114821e-06 0.000587708362116832 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 3 2 6557 26503 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 0.999924542539143 0.999727448570663 0.999990861620785 0.6 0.146632799634673 0.947255049473683 1 0.025 1 0.333333333333333 0.00840375865961264 0.905700675949754 Inf 0.103623605669346 Inf 0.198360606152263 127 4087 False False 0 0 0 0 0 0 0 6.06290986731737 0.694321240468692 72.4391518330217 0.000152485513876181 3.86059150860036e-06 0.000849298834468653 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Arg559Pro embB_p.Arg559Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3702 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3052 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Arg568His embB_p.Arg568His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Arg573Gln embB_p.Arg573Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Arg61Pro embB_p.Arg61Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Arg61Trp embB_p.Arg61Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Arg620Cys embB_p.Arg620Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 10 0 10 0 11 9481 35694 0 0 0.00038900558066021 0.999691919899173 0.999448826618347 0.999846197812 0 0 0.284914152918154 0 0 0.30849710781876 0 0 0.284914152918154 0 0 1.67991826094729 0.134580049474634 134.5 4975 False False 0 0 1.50034693324555 0 0 0.00038900558066021 0.999691919899173 0.999448826618347 0.999846197812 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Arg620Pro embB_p.Arg620Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Arg623Pro embB_p.Arg623Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Arg691His embB_p.Arg691His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3645 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3005 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Arg728Gln embB_p.Arg728Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3652 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3012 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Arg741Trp embB_p.Arg741Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 12 9481 35693 0 0 0.00038900558066021 0.99966391261728 0.999412996653316 0.999826327071809 0 0 0.264648469397051 0 0 0.975 0 0 0.264648469397051 0 0 146.493125728043 1 3243.5 4975 False False 0 0 1.35519147325258 0 0 0.00038900558066021 0.99966391261728 0.999412996653316 0.999826327071809 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 12 6560 26493 0 0 0.000562171107654053 0.999547255234861 0.999209279704825 0.999766038988972 0 0 0.264648469397051 0 0 0.975 0 0 0.264648469397051 0 0 157.125814556592 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 1.45386850159099 0 0 0.000562171107654053 0.999547255234861 0.999209279704825 0.999766038988972 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Arg7Thr embB_p.Arg7Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 4.10971321225031 0.590981128432313 516.5 4975 False False 0 0 3.19822685561766 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 6.12080991862283 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Arg930His embB_p.Arg930His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Arg972His embB_p.Arg972His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3593 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Asn1004Thr embB_p.Asn1004Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Asn129Asp embB_p.Asn129Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Asn13Ser embB_p.Asn13Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 7 199 9474 35506 0.000738318742748655 0.00029689231210758 0.00152062336565454 0.994426550903234 0.993598720335067 0.995172318015163 0.0339805825242718 0.0137690938668109 0.068756935716949 NA NA NA 0 0 0.0183663276944152 NA NA NA NA NA NA False True 0.131829720695518 0.0523237898226496 0.276824554850115 0 0 0.000389292947027732 0.994426550903234 0.993598720335067 0.995172318015163 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 6 192 6554 26313 0.000914634146341463 0.000335726224038477 0.00198970246660848 0.992756083757781 0.991660393086048 0.993741553520152 0.0303030303030303 0.0112002560111435 0.0647869703340023 NA NA NA 0 0 0.0190295221687798 NA NA NA NA NA NA False True 1 1 1 0 0 1 1 0.125462503814464 0.0454624121107557 0.278321253600189 0 0 0.000562685614442453 0.992756083757781 0.991660393086048 0.993741553520152 12 Not assoc w R 5) Not assoc w R No change yes 1 +Ethambutol embB p.Asn160Asp embB_p.Asn160Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Asn296His embB_p.Asn296His 1 missense_variant (see "Genomic_coordinates" sheet) 1 39 11 28 40 43 9441 35662 0.00421896424427803 0.00301574918138985 0.00574064600943082 0.998795686878588 0.998378137129092 0.999128299767525 0.481927710843373 0.370828351817118 0.594354181244247 0.282051282051282 0.15001413047052 0.44873632339492 0.203703703703703 0.106319252490214 0.335304919489249 1.48396053686806 0.666402316010051 3.0761822544965 0.322594135671578 263 4975 False False 3.5138177617172 2.22489332820057 5.53869014742775 0.00116377486246297 0.000581090846771618 0.00208135838808217 0.998795686878588 0.998378137129092 0.999128299767525 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 34 11 23 36 28 6524 26477 0.00548780487804878 0.00384646348156392 0.00758941639905408 0.998943595548009 0.998473560567847 0.999297915712891 0.5625 0.432758900066459 0.686265246451503 0.323529411764705 0.173883427493921 0.505265300898504 0.282051282051282 0.15001413047052 0.44873632339492 1.9409737957508 0.853729365728492 4.14687423560138 0.0820245136674667 78 4087 False False 0 0 0 0 0 0 0 5.21794254182359 3.09368305503553 8.88252098956637 0.0016832440703902 0.000840559442354005 0.00300978806269011 0.998943595548009 0.998473560567847 0.999297915712891 41 3) Uncertain significance No change no 1 +Ethambutol embB p.Asn296Tyr embB_p.Asn296Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 2 3 9479 35702 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.99991597815432 0.999754472342108 0.99998267234027 0.4 0.0527449505263169 0.853367200365326 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.0631165181962 1 2818.5 4975 False False 2.51095403875232 0.209684820120099 21.9222407664312 0 0 0.000389087642036349 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.5214194708504 1 2276.5 4087 False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 0 0 0.000562256793434776 0.999924542539143 0.999727448570663 0.999990861620785 2 3) Uncertain significance No change no 1 +Ethambutol embB p.Asn318Asp embB_p.Asn318Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 4 3 9477 35702 0.000421896424427802 0.000114964157806894 0.00107986688593449 0.99991597815432 0.999754472342108 0.99998267234027 0.571428571428571 0.184051567640083 0.901011721557492 0 0 0.975 0 0 0.707598226178713 0 0 146.591683314664 1 2818.5 4975 False False 5.02296788716541 0.849591990333142 34.2786899066791 0 0 0.000389169738041761 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 2 6557 26503 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 0.999924542539143 0.999727448570663 0.999990861620785 0.6 0.146632799634673 0.947255049473683 0 0 0.975 0 0 0.841886116991581 0 0 157.256714640958 1 2276.5 4087 False False 0 0 0 0 0 0 0 6.06290986731737 0.694321240468692 72.4391518330217 0 0 0.000562428243381166 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Asn399Thr embB_p.Asn399Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 2 1 5 2 9476 35703 0.000527370530534753 0.000171257241502832 0.00123027414547083 0.999943985436213 0.999797670939776 0.99999321630447 0.714285714285714 0.290420863737342 0.963307433823914 0.666666666666666 0.0942993240502461 0.991596241340387 0.5 0.067585986488543 0.932414013511457 7.53545799915576 0.392233546161201 443.2750944674 0.113546544064659 130 4975 False False 9.4193224989447 1.54161474423025 98.9467001652174 0.000211014982063726 2.55559149517483e-05 0.000762048603103055 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 4 1 6556 26504 0.000609756097560975 0.000166162208307701 0.00156047520083291 0.999962271269571 0.999789807096406 0.999999044791703 0.8 0.28358206388191 0.994949236620532 1 0.158113883008419 1 0.666666666666666 0.0942993240502461 0.991596241340387 Inf 0.759080636458041 Inf 0.0393397403224364 65 4087 False False 0 0 0 0 0 0 0 16.1708358755338 1.59970034177407 792.771744020614 0.000304971027752363 3.69355404059544e-05 0.00110122145855773 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Asn400Ser embB_p.Asn400Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Asn400Tyr embB_p.Asn400Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3703 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3053 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Asn522His embB_p.Asn522His 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3530 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2913 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Asn522Thr embB_p.Asn522Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3531 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2914 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Asn644Ile embB_p.Asn644Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.096562813829025 Inf 0.209821626167397 198.5 4975 False False Inf 0.096562813829025 Inf 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.103599830448027 Inf 0.198397096627854 142 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Asn644Thr embB_p.Asn644Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3668 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3025 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Asn657Asp embB_p.Asn657Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3500 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2885 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Asn791Ser embB_p.Asn791Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3695 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Asn807Asp embB_p.Asn807Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 11 0 11 0 12 9481 35693 0 0 0.00038900558066021 0.99966391261728 0.999412996653316 0.999826327071809 0 0 0.264648469397051 0 0 0.284914152918154 0 0 0.264648469397051 0 0 1.50030489649552 0.135454869906327 152.5 4975 False False 0 0 1.35519147325258 0 0 0.00038900558066021 0.99966391261728 0.999412996653316 0.999826327071809 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 7 6560 26498 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 2.80327602229365 0.357905531825047 211.5 4087 False False 0 0 0 0 0 0 0 0 0 2.80327602229365 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 2 3) Uncertain significance No change no 1 +Ethambutol embB p.Asn807Thr embB_p.Asn807Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Asn886His embB_p.Asn886His 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Asn886Thr embB_p.Asn886Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Asn931Asp embB_p.Asn931Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Asp1017Glu embB_p.Asp1017Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3653 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3013 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Asp1024Asn embB_p.Asp1024Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 83 26 57 178 113 9303 35592 0.0187743908870372 0.0161382251160229 0.0217117639575222 0.996835177146058 0.996196228667532 0.99739104804965 0.61168384879725 0.55306282969538 0.668005916562202 0.313253012048192 0.215860998329286 0.424425223609182 0.18705035971223 0.125976375103941 0.261935198906344 1.74513032015705 1.05258356623441 2.82292650009013 0.0211250841573362 69 4975 False False 6.02658006409579 4.72893181572222 7.70640633711195 0.00278700825383213 0.00182134927468791 0.00408096481355857 0.996835177146058 0.996196228667532 0.99739104804965 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 46 18 28 126 69 6434 26436 0.0192073170731707 0.0160247923448715 0.0228267458806019 0.997396717600452 0.996706518810463 0.997973943506422 0.646153846153846 0.574649105916931 0.713139015127381 0.391304347826087 0.250879411560762 0.546258620587539 0.206896551724137 0.127474866870134 0.30713164752356 2.64136951019139 1.3750584713845 4.94990509831328 0.00226401918116438 31 4087 False False 0 0 0 0 0 0 0 7.50302063764511 5.54221025306553 10.2275357919537 0.00278983261004339 0.00165424381985256 0.00440556801616137 0.997396717600452 0.996706518810463 0.997973943506422 66 3) Uncertain significance No change no 1 +Ethambutol embB p.Asp1041Ala embB_p.Asp1041Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3696 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3048 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Asp1056Ala embB_p.Asp1056Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 3 0 9478 35705 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 1 0.999896689850119 1 1 0.292401773821286 1 1 0.025 1 1 0.025 1 Inf 0.0965831879183891 Inf 0.209786650141643 171.5 4975 False False Inf 1.55639137151076 Inf 0.000105496360375567 2.67093302808208e-06 0.000587646375974446 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Asp1056Glu embB_p.Asp1056Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Asp1060Asn embB_p.Asp1060Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Asp1068Tyr embB_p.Asp1068Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3608 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2974 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Asp1072Asn embB_p.Asp1072Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Asp108Asn embB_p.Asp108Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 9479 35704 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999971992718106 0.999843963402622 0.999999290917266 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 146.569015564619 1 2818.5 4975 False False 7.53328410169849 0.392120325718966 443.147628387906 0 0 0.000389087642036349 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 6558 26504 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999962271269571 0.999789807096406 0.999999044791703 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 157.238712024072 1 1103 4087 False False 0 0 0 0 0 0 0 8.08295211954864 0.420719628662148 475.373667785977 0 0 0.00056234250533983 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Asp127Ala embB_p.Asp127Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Asp166Ala embB_p.Asp166Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Asp178Asn embB_p.Asp178Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3654 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Asp178His embB_p.Asp178His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Asp191Glu embB_p.Asp191Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Asp191Tyr embB_p.Asp191Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 3501 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 2886 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 2 3) Uncertain significance No change no 1 +Ethambutol embB p.Asp207Asn embB_p.Asp207Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3572 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Asp207Glu embB_p.Asp207Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3609 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Asp240Asn embB_p.Asp240Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Asp240Gly embB_p.Asp240Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Asp240Tyr embB_p.Asp240Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Asp240Val embB_p.Asp240Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Asp243His embB_p.Asp243His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Asp280Asn embB_p.Asp280Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Asp280Tyr embB_p.Asp280Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3632 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2993 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Asp300Glu embB_p.Asp300Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3562 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2941 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 2 3) Uncertain significance No change no 1 +Ethambutol embB p.Asp300Gly embB_p.Asp300Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3697 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3049 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Asp311Ala embB_p.Asp311Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.058895521352 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 21.5173342675905 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Asp311Phe embB_p.Asp311Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Asp328Ala embB_p.Asp328Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 2 9479 35703 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999943985436213 0.999797670939776 0.99999321630447 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3663 4975 False False 3.76653655448887 0.272970929153834 51.9466713138689 0 0 0.000389087642036349 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3021 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Asp328Gly embB_p.Asp328Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 2 3 46 18 9435 35687 0.00485180888091973 0.00355425838847881 0.00646638841531092 0.99949586892592 0.999203372130377 0.999701193476901 0.71875 0.592399703677967 0.824033676883928 0.4 0.0527449505263169 0.853367200365326 0.1 0.0123485271702948 0.316982714019082 2.52160395689807 0.210574128970547 22.015232157676 0.281495182635852 260 4975 False False 9.66614850144262 5.4943746508778 17.719194736054 0.000211931757973932 2.56669496647521e-05 0.00076535848376326 0.99949586892592 0.999203372130377 0.999701193476901 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 1 3 31 14 6529 26491 0.00472560975609756 0.00321301337622354 0.00670097545873859 0.999471797774004 0.999113925067086 0.999711197799087 0.688888888888888 0.533508970087884 0.818341196066277 0.25 0.00630946320970987 0.805879550316756 0.0666666666666666 0.0016864302413527 0.319484566578303 1.35247868484198 0.025758841925648 16.8454747553091 0.585760054384176 245 4087 False False 0 0 0 0 0 0 0 8.98432269216462 4.63662066707776 18.28913679104 0.000153139356814701 3.87714531452494e-06 0.000852939269919986 0.999471797774004 0.999113925067086 0.999711197799087 13 3) Uncertain significance No change no 1 +Ethambutol embB p.Asp328His embB_p.Asp328His 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 1 4 5 8 9476 35697 0.000527370530534753 0.000171257241502832 0.00123027414547083 0.999775941744853 0.999558563909973 0.999903262744512 0.384615384615384 0.13857933889016 0.684222397085936 0.2 0.00505076337946806 0.716417936118089 0.111111111111111 0.00280913674659921 0.482496514917337 0.941773955255382 0.0191212404823328 9.51599077976989 1 2818.5 4975 False False 2.35443488813845 0.6058631448195 8.16437597956903 0.000105518624037142 2.6714966936852e-06 0.000587770361337447 0.999775941744853 0.999558563909973 0.999903262744512 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 5 5 6555 26500 0.000762195121951219 0.000247527523788107 0.00177780526826415 0.999811356347858 0.999559824020536 0.9999387451734 0.5 0.187086028447398 0.812913971552601 0.333333333333333 0.00840375865961264 0.905700675949754 0.166666666666666 0.00421074451448947 0.641234578997674 2.02135774218154 0.0342567147060857 38.7957266841064 0.484775540016158 238 4087 False False 0 0 0 0 0 0 0 4.04271548436308 0.930054868102617 17.5613448179105 0.000152532031726662 3.86176923405925e-06 0.000849557834692023 0.999811356347858 0.999559824020536 0.9999387451734 4 3) Uncertain significance No change no 1 +Ethambutol embB p.Asp328Ile embB_p.Asp328Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3594 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2964 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Asp328Phe embB_p.Asp328Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.707313928675496 Inf 0.0440214455254381 88.5 4975 False False Inf 0.707313928675496 Inf 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.758877818966333 Inf 0.0393565980154275 66.5 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Asp328Tyr embB_p.Asp328Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 25 21 4 46 5 9435 35700 0.00485180888091973 0.00355425838847881 0.00646638841531092 0.999859963590533 0.999673232250017 0.999954529045718 0.901960784313725 0.785855017454319 0.967393510448109 0.84 0.639171545540727 0.95462054762829 0.807692307692307 0.606494472060678 0.934451891263217 19.8648648648648 6.69970150642629 79.5589889289293 2.80679301315093e-11 10 4975 True False 34.8108108108108 13.882407078839 111.878742611794 0.00222081218274111 0.00137522704471704 0.003392754460819 0.999859963590533 0.999673232250017 0.999954529045718 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 13 11 2 29 2 6531 26503 0.00442073170731707 0.00296257223192387 0.00634278475638182 0.999924542539143 0.999727448570663 0.999990861620785 0.935483870967742 0.785783842836597 0.992089016538145 0.846153846153846 0.545528944323442 0.980793328017471 0.846153846153846 0.545528944323442 0.980793328017471 22.3191701117746 4.86873386257914 206.63816062788 9.50625501943079e-07 15 4087 True False 0 0 0 0 0 0 0 58.8414484764967 14.8715663489947 508.315002825687 0.001681442983797 0.000839659725791671 0.00300656970004808 0.999924542539143 0.999727448570663 0.999990861620785 9 Assoc w R 1) Assoc w R No change yes 1 +Ethambutol embB p.Asp328Val embB_p.Asp328Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3638 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2998 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Asp354_Leu355insHis embB_p.Asp354_Leu355insHis 1 inframe_insertion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.096562813829025 Inf 0.209821626167397 198.5 4975 False False Inf 0.096562813829025 Inf 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.103599830448027 Inf 0.198397096627854 142 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Asp354Ala embB_p.Asp354Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 268 172 96 301 137 9180 35568 0.0317477059381921 0.0283102862168181 0.0354765931847393 0.996163002380619 0.995465627661623 0.996777639935944 0.687214611872146 0.641495463927263 0.730382985302718 0.641791044776119 0.581199958446188 0.699207279374339 0.556634304207119 0.499307624020295 0.612864769381245 6.94183006535947 5.37045381218224 9.01479777107758 1.63764125548554e-53 5 4975 True False 8.51260913124373 6.92147521538815 10.5090725022827 0.0183917878528656 0.0157659488823292 0.0213233584627368 0.996163002380619 0.995465627661623 0.996777639935944 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 219 158 61 261 86 6299 26419 0.0397865853658536 0.0351861236877354 0.0448016570426599 0.996755329183173 0.99599438641369 0.997403887658634 0.752161383285302 0.703252826389316 0.796708021339527 0.721461187214611 0.657069111322689 0.779748663685125 0.647540983606557 0.58403691172678 0.707411012981778 10.8635562761718 8.02430554187418 14.8701325052087 8.68459316042937e-64 4 4087 True False 0 0 0 0 0 0 0 12.7287812388086 9.91976764547838 16.4610739956911 0.0244695679107944 0.0208396554754511 0.0285371734199421 0.996755329183173 0.99599438641369 0.997403887658634 226 Assoc w R 1) Assoc w R No change yes 1 +Ethambutol embB p.Asp354Asn embB_p.Asp354Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3555 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2934 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Asp354dup embB_p.Asp354dup 1 inframe_insertion (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3597 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Asp354Gly embB_p.Asp354Gly 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Asp496Asn embB_p.Asp496Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3563 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2942 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Asp57Gly embB_p.Asp57Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 157.21479794295 1 1103 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Asp664Gly embB_p.Asp664Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3683 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3037 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Asp752His embB_p.Asp752His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Asp758Asn embB_p.Asp758Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Asp78Ala embB_p.Asp78Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Asp78Glu embB_p.Asp78Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Asp78Gly embB_p.Asp78Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 1 11 9480 35694 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999691919899173 0.999448826618347 0.999846197812 0.0833333333333333 0.00210759323186022 0.384796165150944 0 0 0.602364635616474 0 0 0.284914152918154 0 0 5.70463649113369 0.585892438196061 363 4975 False False 0.34228998849252 0.00795492252872522 2.35571643249047 0 0 0.00038904660702099 0.999691919899173 0.999448826618347 0.999846197812 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 8 6560 26497 0 0 0.000562171107654053 0.999698170156574 0.999405361976814 0.999869682578628 0 0 0.369416647552819 0 0 0.707598226178713 0 0 0.369416647552819 0 0 9.77799526543077 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 2.36695385477914 0 0 0.000562171107654053 0.999698170156574 0.999405361976814 0.999869682578628 3 3) Uncertain significance No change no 1 +Ethambutol embB p.Asp814Ala embB_p.Asp814Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Asp814Asn embB_p.Asp814Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3573 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2948 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Asp816His embB_p.Asp816His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3574 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2949 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Asp869Glu embB_p.Asp869Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Asp869Gly embB_p.Asp869Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 8 9481 35697 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 0 0 0.369416647552819 0 0 0.521823750104981 0 0 0.369416647552819 0 0 4.10948297692623 0.590982254518448 523.5 4975 False False 0 0 2.20624116275339 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 6 6560 26499 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 4.40926527811573 0.590385229079199 260 4087 False False 0 0 0 0 0 0 0 0 0 3.43165838346939 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Asp869His embB_p.Asp869His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Asp870Asn embB_p.Asp870Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12104088004766 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Asp920Asn embB_p.Asp920Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3684 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3038 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Asp952Glu embB_p.Asp952Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Asp970Ala embB_p.Asp970Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Asp970Glu embB_p.Asp970Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Asp970Gly embB_p.Asp970Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.11527461591697 1 2818.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Cys361Ser embB_p.Cys361Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 41 2 39 7 42 9474 35663 0.000738318742748655 0.00029689231210758 0.00152062336565454 0.998823694160481 0.99841030518573 0.999152094778215 0.142857142857142 0.059421505690313 0.272421512695597 0.048780487804878 0.00596311824104283 0.16533335341783 0.0454545454545454 0.00555295199537049 0.154731577658989 0.19304114364279 0.0225783305603422 0.745896650856964 0.00683089037050655 48 4975 False False 0.627383716839068 0.237722873235433 1.41001677042433 0.000211059518784297 2.55613089865548e-05 0.000762209396374794 0.998823694160481 0.99841030518573 0.999152094778215 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 34 1 33 6 36 6554 26469 0.000914634146341463 0.000335726224038477 0.00198970246660848 0.998641765704584 0.998120122196907 0.999048533698614 0.142857142857142 0.0542838583787648 0.285393841913271 0.0294117647058823 0.00074436423469026 0.153267669560317 0.027027027027027 0.000684031024694665 0.141603095611158 0.122381890309873 0.00301179456845344 0.731370306503725 0.00864891310506811 40 4087 False False 0 0 0 0 0 0 0 0.673100396704302 0.231717126568235 1.61385168153993 0.00015255530129672 3.86235836629056e-06 0.000849687394050823 0.998641765704584 0.998120122196907 0.999048533698614 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Cys361Tyr embB_p.Cys361Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0965729997991255 Inf 0.209804138541551 175.5 4975 False False Inf 0.707313928675496 Inf 0.00010548523206751 2.670651284468e-06 0.000587584402906152 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.103615625538654 Inf 0.198372852649407 128.5 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0.000152462265589266 3.86000291520843e-06 0.000849169393567967 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Cys4Ser embB_p.Cys4Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Cys549Phe embB_p.Cys549Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 9480 35702 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99991597815432 0.999754472342108 0.99998267234027 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11649128277037 1 2818.5 4975 False False 1.25534458509142 0.0239099774609589 15.6346568618898 0 0 0.00038904660702099 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3014 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Cys549Tyr embB_p.Cys549Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gln112His embB_p.Gln112His 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Gln139His embB_p.Gln139His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 145 9480 35560 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.995938944125472 0.995223258294382 0.996571993349208 0.00684931506849315 0.000173394609144803 0.0375697930933849 NA NA NA 0 0 0.0251196641318021 NA NA NA NA NA NA False True 0.0258693438091081 0.000654989370995514 0.146499989040605 0 0 0.00038904660702099 0.995938944125472 0.995223258294382 0.996571993349208 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 1 138 6559 26367 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.994793435200905 0.993851626294877 0.995624106694302 0.00719424460431654 0.000182125916545389 0.0394307688737217 NA NA NA 0 0 0.0263768993409614 NA NA NA NA NA NA False True 1 1 1 0 0 1 1 0.029130235918784 0.000736616272654602 0.165095557663779 0 0 0.000562256793434776 0.994793435200905 0.993851626294877 0.995624106694302 9 Not assoc w R 5) Not assoc w R No change yes 1 +Ethambutol embB p.Gln144Pro embB_p.Gln144Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3708 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3059 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gln3Arg embB_p.Gln3Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3535 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gln3His embB_p.Gln3His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Gln445Arg embB_p.Gln445Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 86 2 9395 35703 0.00907077312519776 0.00726166861978513 0.0111903740239994 0.999943985436213 0.999797670939776 0.99999321630447 0.977272727272727 0.920302691028678 0.99723567292383 1 0.158113883008419 1 0.5 0.067585986488543 0.932414013511457 Inf 0.71359720265333 Inf 0.0434098995513639 83 4975 False False 163.409153805215 43.8665668874726 1380.98990378881 0.000212833883154198 2.57762100018646e-05 0.000768615462441551 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 30 1 6530 26504 0.00457317073170731 0.00308756239284879 0.00652210018905333 0.999962271269571 0.999789807096406 0.999999044791703 0.967741935483871 0.832978883769772 0.999183629928153 1 0.158113883008419 1 0.666666666666666 0.0942993240502461 0.991596241340387 Inf 0.762102380733907 Inf 0.0390898578602502 64 4087 False False 0 0 0 0 0 0 0 121.764165390505 20.2237677012036 4824.20164151689 0.000306184935701163 3.70825673141323e-05 0.00110560301202144 0.999962271269571 0.999789807096406 0.999999044791703 105 3) Uncertain significance No change no 1 +Ethambutol embB p.Gln497Arg embB_p.Gln497Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 518 378 140 999 224 8482 35481 0.105368632000843 0.099257665294317 0.111723219217735 0.993726368855902 0.992851906608634 0.994518991541889 0.816843826655764 0.794004415472492 0.838148263129354 0.729729729729729 0.689280056001963 0.767534878796884 0.627906976744186 0.587912163546971 0.666640241358488 11.2943527469936 9.26426793673861 13.829804932846 1.49221680681871e-151 3 4975 True False 18.6558505195877 16.0872907032825 21.690634002782 0.0426636568848758 0.0385500885949601 0.0470812501039636 0.993726368855902 0.992851906608634 0.994518991541889 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 348 274 74 591 112 5969 26393 0.0900914634146341 0.083270126719019 0.0972796754623511 0.995774382192039 0.994917668905929 0.996519405124771 0.840682788051209 0.811498489091262 0.866971481527409 0.78735632183908 0.740567704163137 0.829178163414419 0.709844559585492 0.661784073383537 0.754652916162955 16.3721615735353 12.5983973671173 21.501072228675 1.50066491296008e-129 3 4087 True False 0 0 0 0 0 0 0 23.3322508556111 18.9901155177292 28.8805238343897 0.0438891558545571 0.0389418521780481 0.0492680392229074 0.995774382192039 0.994917668905929 0.996519405124771 420 Assoc w R 1) Assoc w R No change yes 1 +Ethambutol embB p.Gln497Glu embB_p.Gln497Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3722 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gln497His embB_p.Gln497His 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 28 8 9453 35697 0.00295327497099462 0.00196329943540529 0.00426549739700822 0.999775941744853 0.999558563909973 0.999903262744512 0.777777777777777 0.608482350842618 0.898849469655087 0 0 0.707598226178713 0 0 0.369416647552819 0 0 9.14124621332994 1 2818.5 4975 False False 13.2169152649952 5.86609758670075 33.5647600980523 0 0 0.000390157599189114 0.999775941744853 0.999558563909973 0.999903262744512 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 22 4 6538 26501 0.00335365853658536 0.00210287680624562 0.00507310205385763 0.999849085078287 0.999613643356053 0.999958879281354 0.846153846153846 0.651321214464638 0.956436523461076 NA NA NA 0 0 0.602364635616474 NA NA NA NA 2979 4087 False False 0 0 0 0 0 0 0 22.2935913123279 7.56691734548287 89.076169191917 0 0 0.000564062248005687 0.999849085078287 0.999613643356053 0.999958879281354 7 3) Uncertain significance No change no 1 +Ethambutol embB p.Gln497Leu embB_p.Gln497Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3709 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3060 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gln497Lys embB_p.Gln497Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 66 35 31 145 51 9336 35654 0.0152937453855078 0.0129205939129316 0.0179710660624496 0.998571628623442 0.998122377764315 0.99893630448237 0.739795918367346 0.672473299569808 0.799711536945324 0.53030303030303 0.403420053441724 0.654378697236779 0.406976744186046 0.302244598839298 0.518305307281827 4.3117519418415 2.58079390626486 7.23606619611604 7.8497473931843e-09 13 4975 True False 10.8578851420602 7.83230696382095 15.2592994159497 0.00373492690214491 0.00260285067964409 0.00519058718699894 0.998571628623442 0.998122377764315 0.99893630448237 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 55 34 21 98 34 6462 26471 0.0149390243902439 0.0121444194641604 0.0181760718321121 0.99871722316544 0.998207904910638 0.999111481246239 0.742424242424242 0.659088076583859 0.814561215783364 0.618181818181818 0.477262254960502 0.745908351677454 0.5 0.376203580890874 0.623796419109125 6.63228250136328 3.73657108046574 12.0330619955174 9.49244394003994e-12 9 4087 True False 0 0 0 0 0 0 0 11.8072987783785 7.91115119978038 18.0029130024305 0.00523399014778325 0.00362733282164595 0.00730636592648992 0.99871722316544 0.998207904910638 0.999111481246239 93 Assoc w R 1) Assoc w R No change yes 1 +Ethambutol embB p.Gln497Pro embB_p.Gln497Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 23 6 17 39 28 9442 35677 0.00411349013817107 0.00292667969846249 0.00561902942957354 0.999215796106988 0.998866804929334 0.999478840936165 0.582089552238806 0.455172444701943 0.701510591916579 0.260869565217391 0.102286133915358 0.484051970402438 0.176470588235294 0.0676406526827571 0.345315131068133 1.33360329940067 0.430388044234595 3.54614890855074 0.606549414910867 526 4975 False False 5.26297016370623 3.15479245324828 8.88347813106437 0.000635055038103302 0.000233088526037293 0.00138173111410852 0.999215796106988 0.998866804929334 0.999478840936165 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 15 6 9 27 19 6533 26486 0.00411585365853658 0.00271407267173401 0.00598274243419924 0.999283154121863 0.998880781714398 0.999568358524102 0.58695652173913 0.432272407562019 0.7300254221893 0.4 0.163364323859513 0.677130233793718 0.24 0.0935644393317428 0.451288017816686 2.70279095872238 0.791308492101122 8.50551942646947 0.0949334968790097 95 4087 False False 0 0 0 0 0 0 0 5.76121230675034 3.08462215234248 10.9700528552121 0.000917571494112249 0.000336804639692832 0.00199608894645829 0.999283154121863 0.998880781714398 0.999568358524102 9 3) Uncertain significance No change no 1 +Ethambutol embB p.Gln516Glu embB_p.Gln516Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3710 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3061 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gln51Pro embB_p.Gln51Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 8 9481 35697 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 0 0 0.369416647552819 0 0 0.4592581264399 0 0 0.369416647552819 0 0 3.19804752107404 0.354692794889658 274.5 4975 False False 0 0 2.20624116275339 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 2 3) Uncertain significance No change no 1 +Ethambutol embB p.Gln63Lys embB_p.Gln63Lys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 9478 35705 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 1 0.999896689850119 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3723 4975 False False Inf 1.55639137151076 Inf 0 0 0.000389128685709026 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 6557 26505 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 1 0.999860832946126 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3072 4087 False False 0 0 0 0 0 0 0 Inf 1.66990152933523 Inf 0 0 0.000562428243381166 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Gln729Pro embB_p.Gln729Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3698 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3050 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Gln853Arg embB_p.Gln853Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 7 1 9474 35704 0.000738318742748655 0.00029689231210758 0.00152062336565454 0.999971992718106 0.999843963402622 0.999999290917266 0.875 0.473490329124793 0.996840276468748 NA NA NA 0 0 0.975 NA NA NA NA 3727 4975 False False 26.3804095419041 3.38816818189886 1181.46969547968 0 0 0.000389292947027732 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 5 1 6555 26504 0.000762195121951219 0.000247527523788107 0.00177780526826415 0.999962271269571 0.999789807096406 0.999999044791703 0.833333333333333 0.358765421002325 0.99578925548551 NA NA NA 0 0 0.975 NA NA NA NA 3075 4087 False False 0 0 0 0 0 0 0 20.2166285278413 2.26137738039683 951.169010205643 0 0 0.00056259979792051 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gln853His embB_p.Gln853His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3556 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2935 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gln853Pro embB_p.Gln853Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 13 10 9468 35695 0.00137116337939035 0.000730282374626527 0.00234358976784705 0.999719927181067 0.999484996631079 0.999865686288203 0.565217391304347 0.344946607452374 0.768085800461768 0 0 0.521823750104981 0 0 0.30849710781876 0 0 4.11489570518952 0.59095604857495 460 4975 False False 4.90108787494719 1.98450729127573 12.4894904277675 0 0 0.000389539599191658 0.999719927181067 0.999484996631079 0.999865686288203 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 3 7 6557 26498 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 0.999735898887002 0.999455926960675 0.999893811273379 0.3 0.0667395111777345 0.652452850059997 0 0 0.521823750104981 0 0 0.409616397225003 0 0 4.41111657765145 0.590386618899978 298.5 4087 False False 0 0 0 0 0 0 0 1.73193315758513 0.288910719135753 7.58884844433105 0 0 0.000562428243381166 0.999735898887002 0.999455926960675 0.999893811273379 18 3) Uncertain significance No change no 1 +Ethambutol embB p.Gln925Pro embB_p.Gln925Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3550 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2929 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gln982del embB_p.Gln982del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Glu1008Ala embB_p.Glu1008Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Glu1008Lys embB_p.Glu1008Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3728 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3076 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Glu138Ala embB_p.Glu138Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Glu138Gly embB_p.Glu138Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Glu138Lys embB_p.Glu138Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 9479 35704 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999971992718106 0.999843963402622 0.999999290917266 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 146.569015564619 1 2818.5 4975 False False 7.53328410169849 0.392120325718966 443.147628387906 0 0 0.000389087642036349 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 6558 26504 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999962271269571 0.999789807096406 0.999999044791703 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 157.238712024072 1 1103 4087 False False 0 0 0 0 0 0 0 8.08295211954864 0.420719628662148 475.373667785977 0 0 0.00056234250533983 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Glu149Ala embB_p.Glu149Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Glu149Lys embB_p.Glu149Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Glu378Ala embB_p.Glu378Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 335 4027 9146 31678 0.0353338255458285 0.0317081973694603 0.0392484107646506 0.887214675815712 0.88388799483668 0.890478228049481 0.0767996331957817 0.0690684559092483 0.0851029537596006 NA NA NA 0 0 0.000915617182908647 NA NA NA NA NA NA False True 0.288130833037069 0.256339859245249 0.322996533022014 0 0 0.000403251217095035 0.887214675815712 0.88388799483668 0.890478228049481 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 251 3386 6309 23119 0.0382621951219512 0.033750233130244 0.0431903020087796 0.872250518770043 0.868172129220113 0.876247109157552 0.0690129227385207 0.0609865705603321 0.0777399975339835 NA NA NA 0 0 0.00108885728228659 NA NA NA NA NA NA False True 1 1 1 0 0 1 1 0.271640977922107 0.237276220452951 0.309889720508352 0 0 0.000584530229556637 0.872250518770043 0.868172129220113 0.876247109157552 678 Not assoc w R 5) Not assoc w R No change yes 1 +Ethambutol embB p.Glu378Asp embB_p.Glu378Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Glu405Asp embB_p.Glu405Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 15 9 6 49 9 9432 35696 0.00516823119924058 0.00382585921919218 0.00682698553108318 0.99974793446296 0.999521555266748 0.999884733314884 0.844827586206896 0.725768475995871 0.92650672813375 0.6 0.322869766206281 0.836635676140486 0.5 0.260190582895097 0.739809417104903 5.67684478371501 1.80394666976079 19.3847364860776 0.0011032670892186 31 4975 False False 20.6048440297804 10.0076688464889 47.7345373213707 0.000953288846520495 0.000435994077609746 0.00180886438418291 0.99974793446296 0.999521555266748 0.999884733314884 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 2 3 37 5 6523 26500 0.00564024390243902 0.00397426947496204 0.0077660324341956 0.999811356347858 0.999559824020536 0.9999387451734 0.88095238095238 0.743683322393622 0.960194471057311 0.4 0.0527449505263169 0.853367200365326 0.285714285714285 0.0366925661760855 0.709579136262657 2.70836527160304 0.226155932047875 23.6470121453207 0.25772343427539 181 4087 False False 0 0 0 0 0 0 0 30.0628545147938 11.7816903876002 98.0638057796452 0.000306513409961685 3.71223516891364e-05 0.00110678862468284 0.999811356347858 0.999559824020536 0.9999387451734 21 3) Uncertain significance No change no 1 +Ethambutol embB p.Glu405Gly embB_p.Glu405Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3536 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2918 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Glu504Ala embB_p.Glu504Ala 1 missense_variant (see "Genomic_coordinates" sheet) 2 2 2 0 3 0 9478 35705 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 1 0.999896689850119 1 1 0.292401773821286 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.707388546449333 Inf 0.0440141074104852 86 4975 False False Inf 1.55639137151076 Inf 0.000210970464135021 2.55505231929967e-05 0.00076188787765788 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 6557 26505 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 1 0.999860832946126 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3077 4087 False False 0 0 0 0 0 0 0 Inf 1.66990152933523 Inf 0 0 0.000562428243381166 1 0.999860832946126 1 3 3) Uncertain significance No change no 1 +Ethambutol embB p.Glu504Asp embB_p.Glu504Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 2 2 19 12 9462 35693 0.00200400801603206 0.00120696150945356 0.00312774546302964 0.99966391261728 0.999412996653316 0.999826327071809 0.612903225806451 0.421869589134041 0.781500401501431 0.5 0.067585986488543 0.932414013511457 0.142857142857142 0.0177945154831915 0.428129160909698 3.7722468822659 0.273384728278173 52.0250516107574 0.19566500735661 160 4975 False False 5.97272423025435 2.75153211857795 13.4932436539742 0.000211327134404057 2.55937210733594e-05 0.000763175582770455 0.99966391261728 0.999412996653316 0.999826327071809 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 2 2 18 9 6542 26496 0.00274390243902439 0.00162699615274529 0.00433309514094649 0.999660441426146 0.999355510362951 0.999844720818052 0.666666666666666 0.460392713907742 0.834811820312684 0.5 0.067585986488543 0.932414013511457 0.181818181818181 0.0228311982999596 0.517755852360172 4.05013757260776 0.293504949062975 55.8334001050853 0.177804230119164 118 4087 False False 0 0 0 0 0 0 0 8.10027514521553 3.45340114275712 20.4698431365125 0.00030562347188264 3.7014563558511e-05 0.00110357643196295 0.999660441426146 0.999355510362951 0.999844720818052 7 3) Uncertain significance No change no 1 +Ethambutol embB p.Glu504Gly embB_p.Glu504Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 0 9477 35705 0.000421896424427802 0.000114964157806894 0.00107986688593449 1 0.999896689850119 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3685 4975 False False Inf 2.4863933079676 Inf 0 0 0.000389169738041761 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3039 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Glu521Ala embB_p.Glu521Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 2 9479 35703 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999943985436213 0.999797670939776 0.99999321630447 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 146.564919965648 1 1480 4975 False False 3.76653655448887 0.272970929153834 51.9466713138689 0 0 0.000389087642036349 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Glu901Asp embB_p.Glu901Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 13 0 13 0 13 9481 35692 0 0 0.00038900558066021 0.999635905335387 0.999377467513205 0.999806121137399 0 0 0.24705263800047 0 0 0.24705263800047 0 0 0.24705263800047 0 0 1.2354962611609 0.0841527428150526 121 4975 False False 0 0 1.2354962611609 0 0 0.00038900558066021 0.999635905335387 0.999377467513205 0.999806121137399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 0 9 6560 26496 0 0 0.000562171107654053 0.999660441426146 0.999355510362951 0.999844720818052 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.336267116879942 0 0 2.04691100627475 0.2201316772645 166 4087 False False 0 0 0 0 0 0 0 0 0 2.04691100627475 0 0 0.000562171107654053 0.999660441426146 0.999355510362951 0.999844720818052 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Glu951Gln embB_p.Glu951Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 0 9 0 10 9481 35695 0 0 0.00038900558066021 0.999719927181067 0.999484996631079 0.999865686288203 0 0 0.30849710781876 0 0 0.336267116879942 0 0 0.30849710781876 0 0 1.90780977028248 0.219223304182763 249 4975 False False 0 0 1.67996531074212 0 0 0.00038900558066021 0.999719927181067 0.999484996631079 0.999865686288203 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 0 10 6560 26495 0 0 0.000562171107654053 0.999622712695717 0.999306265033238 0.999819061720012 0 0 0.30849710781876 0 0 0.336267116879942 0 0 0.30849710781876 0 0 2.04683374325628 0.220130286309629 162 4087 False False 0 0 0 0 0 0 0 0 0 1.80248078294835 0 0 0.000562171107654053 0.999622712695717 0.999306265033238 0.999819061720012 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Glu951Lys embB_p.Glu951Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3582 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2955 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Glu958Ala embB_p.Glu958Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Glu958Gly embB_p.Glu958Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Glu976Gln embB_p.Glu976Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3508 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Glu976Lys embB_p.Glu976Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Gly1005Ala embB_p.Gly1005Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Gly1005Asp embB_p.Gly1005Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly100Ser embB_p.Gly100Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 1 10 9480 35695 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999719927181067 0.999484996631079 0.999865686288203 0.0909090909090909 0.00229897221381426 0.412779916988382 0 0 0.369416647552819 0 0 0.30849710781876 0 0 2.20635037155645 0.21768536660825 232 4975 False False 0.376529535864978 0.00867884780074745 2.64739955416065 0 0 0.00038904660702099 0.999719927181067 0.999484996631079 0.999865686288203 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 9 6560 26496 0 0 0.000562171107654053 0.999660441426146 0.999355510362951 0.999844720818052 0 0 0.336267116879942 0 0 0.409616397225003 0 0 0.336267116879942 0 0 2.80306448752203 0.357903722971917 205 4087 False False 0 0 0 0 0 0 0 0 0 2.04691100627475 0 0 0.000562171107654053 0.999660441426146 0.999355510362951 0.999844720818052 7 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly1031Ser embB_p.Gly1031Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3617 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2980 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 3 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly1035Ser embB_p.Gly1035Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly106Arg embB_p.Gly106Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly106Val embB_p.Gly106Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly1081Ser embB_p.Gly1081Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3575 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly1087Asp embB_p.Gly1087Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3699 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3051 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly1087Cys embB_p.Gly1087Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly1092Ala embB_p.Gly1092Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly1092Arg embB_p.Gly1092Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3583 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2956 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly1097Ser embB_p.Gly1097Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly156Asp embB_p.Gly156Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.058895521352 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly156Cys embB_p.Gly156Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 74 55 9407 35650 0.00780508385191435 0.00613349571256032 0.00978878943929884 0.998459599495868 0.997995422923695 0.99883935521482 0.573643410852713 0.483568920881137 0.66025914122765 NA NA NA 0 0 0.0648707608254246 NA NA NA NA NA NA False True 5.09891086908201 3.54531747871282 7.37072724088082 0 0 0.000392065086258207 0.998459599495868 0.997995422923695 0.99883935521482 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 45 47 6515 26458 0.00685975609756097 0.00500782563543962 0.00916824054791254 0.998226749669873 0.997642642624476 0.99869680036167 0.489130434782608 0.38340930836456 0.595570585042346 NA NA NA 0 0 0.0754857336910586 NA NA NA NA NA NA False True 0 0 1 0 0 1 1 3.88827746117796 2.52258447226771 5.98567963973223 0 0 0.000566053001526386 0.998226749669873 0.997642642624476 0.99869680036167 65 Not assoc w RI Literature evidence (PMID 32143680) 4) Not assoc w R - Interim No change yes Lit. (PMID 32143680) 1 +Ethambutol embB p.Gly169Asp embB_p.Gly169Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3639 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2999 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly175Arg embB_p.Gly175Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.11527461591697 1 2818.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 21.5173342675905 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 4 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly175Ser embB_p.Gly175Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Gly194Arg embB_p.Gly194Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly199Arg embB_p.Gly199Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 5 9480 35700 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999859963590533 0.999673232250017 0.999954529045718 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.975 0 0 0.521823750104981 0 0 146.537209422986 1 2818.5 4975 False False 0.753164556962025 0.0159260191955521 6.73154939272228 0 0 0.00038904660702099 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 157.173142990263 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly199Glu embB_p.Gly199Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly244Arg embB_p.Gly244Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly246Arg embB_p.Gly246Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 44 1 43 4 48 9477 35657 0.000421896424427802 0.000114964157806894 0.00107986688593449 0.998655650469122 0.99821797803272 0.999008621572115 0.0769230769230769 0.0213565864913836 0.185396604383411 0.0227272727272727 0.000575239213363083 0.120241582206347 0.0204081632653061 0.000516556497593286 0.108541763968406 0.0874994785416835 0.00216930536594641 0.514391009488825 0.000636926285541647 27 4975 False False 0.313539798107699 0.0821002989838144 0.856646969401977 0.000105507491031863 2.67121483114821e-06 0.000587708362116832 0.998655650469122 0.99821797803272 0.999008621572115 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 25 0 25 2 28 6558 26477 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.998943595548009 0.998473560567847 0.999297915712891 0.0666666666666666 0.00817813446065631 0.220735401522961 0 0 0.137185171530712 0 0 0.123436118500263 0 0 0.642168047289444 0.00915371890591268 41 4087 False False 0 0 0 0 0 0 0 0.288382782207118 0.0332764723080387 1.14418574063532 0 0 0.00056234250533983 0.998943595548009 0.998473560567847 0.999297915712891 2 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly25Ala embB_p.Gly25Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3610 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 2975 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly25Arg embB_p.Gly25Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3711 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3062 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly294Ser embB_p.Gly294Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 2 9479 35703 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999943985436213 0.999797670939776 0.99999321630447 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 146.564919965648 1 1480 4975 False False 3.76653655448887 0.272970929153834 51.9466713138689 0 0 0.000389087642036349 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 1 6558 26504 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999962271269571 0.999789807096406 0.999999044791703 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 3054 4087 False False 0 0 0 0 0 0 0 8.08295211954864 0.420719628662148 475.373667785977 0 0 0.00056234250533983 0.999962271269571 0.999789807096406 0.999999044791703 3 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly305Cys embB_p.Gly305Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly314Ser embB_p.Gly314Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly34Arg embB_p.Gly34Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Gly34Val embB_p.Gly34Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly374Glu embB_p.Gly374Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly374Trp embB_p.Gly374Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3688 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Gly37Ser embB_p.Gly37Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12104088004766 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly406Ala embB_p.Gly406Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 279 148 131 328 199 9153 35506 0.0345955068030798 0.0310077331815859 0.0384727503928411 0.994426550903234 0.993598720335067 0.995172318015163 0.622390891840607 0.579458532763973 0.66394234120943 0.530465949820788 0.470057238651058 0.59022076781995 0.426512968299711 0.373858556034958 0.480432302994881 4.38256843165758 3.43625724204878 5.59339460828322 7.51937095775362e-33 6 4975 True False 6.393800094101 5.33618790704325 7.676713106466 0.0159122674981184 0.0134678769220741 0.0186662351640781 0.994426550903234 0.993598720335067 0.995172318015163 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 175 114 61 236 99 6324 26406 0.0359756097560975 0.0316001729736633 0.0407695150254686 0.996264855687606 0.995454443831827 0.996963253489467 0.704477611940298 0.652466050812572 0.752831177722409 0.651428571428571 0.575863958166414 0.721765678038058 0.535211267605633 0.465796336935525 0.603632516930829 7.80343422403334 5.66185824899797 10.8428561850494 1.56570859110845e-39 5 4087 True False 0 0 0 0 0 0 0 9.95376919096084 7.82675685655679 12.7373231507447 0.0177073625349487 0.014628023053473 0.0212339195673597 0.996264855687606 0.995454443831827 0.996963253489467 103 Assoc w R 1) Assoc w R No change yes 1 +Ethambutol embB p.Gly406Asp embB_p.Gly406Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 262 123 139 274 212 9207 35493 0.0288999050733045 0.0256204347372978 0.0324728763257743 0.994062456238622 0.993210028125001 0.994832939725762 0.563786008230452 0.518391982348716 0.608399414648577 0.469465648854961 0.407774746028996 0.531855035665051 0.367164179104477 0.315430783189645 0.421269185275527 3.41126043446767 2.65144456178866 4.3848659094746 2.23779310018432e-21 8 4975 True False 4.98240776603527 4.14295141675335 5.99751228657437 0.0131832797427652 0.010968253406517 0.0157094467607525 0.994062456238622 0.993210028125001 0.994832939725762 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 197 98 99 214 156 6346 26349 0.0326219512195121 0.0284557624848086 0.0372100706568957 0.994114318053197 0.99311827991505 0.994999550874335 0.578378378378378 0.52625046448202 0.629242015337141 0.49746192893401 0.425606953168597 0.56939442695752 0.385826771653543 0.325640547193873 0.448710814703848 4.11012424910943 3.07199738379538 5.49855183745237 1.88722276276525e-21 6 4087 True False 0 0 0 0 0 0 0 5.69578050376978 4.6034235646708 7.06019865785574 0.0152079453755431 0.0123633323552247 0.0185027159158492 0.994114318053197 0.99311827991505 0.994999550874335 95 Assoc w R 1) Assoc w R No change yes 1 +Ethambutol embB p.Gly406Cys embB_p.Gly406Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 43 25 18 36 28 9445 35677 0.00379706781985022 0.00266079394079502 0.00525290420804873 0.999215796106988 0.998866804929334 0.999478840936165 0.5625 0.432758900066459 0.686265246451503 0.581395348837209 0.421269596520751 0.729885877295442 0.471698113207547 0.333024695678895 0.6136447928059 5.24630904064466 2.74815445613534 10.2093245151543 1.15470102068785e-07 15 4975 True False 4.85658322619677 2.87999323812963 8.2660533619352 0.00263991552270327 0.00170912030781163 0.00389458605926256 0.999215796106988 0.998866804929334 0.999478840936165 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 36 23 13 30 19 6530 26486 0.00457317073170731 0.00308756239284879 0.00652210018905333 0.999283154121863 0.998880781714398 0.999568358524102 0.612244897959183 0.462385490920229 0.748025517209223 0.638888888888888 0.462209000168164 0.791777052913407 0.547619047619047 0.386731787237871 0.701541186803682 7.17608670043585 3.48353813648264 15.4248515602761 1.00947784018888e-08 11 4087 True False 0 0 0 0 0 0 0 6.40428790199081 3.48563637860853 12.0498271289841 0.0035098428200824 0.00222620055200241 0.00526186075431601 0.999283154121863 0.998880781714398 0.999568358524102 9 Assoc w R 1) Assoc w R No change yes 1 +Ethambutol embB p.Gly406Ser embB_p.Gly406Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 95 58 37 187 76 9294 35629 0.0197236578419997 0.0170203188631841 0.0227274347388858 0.997871446576109 0.997336511761874 0.998322586648195 0.711026615969581 0.652172430175911 0.765053477346242 0.610526315789473 0.505025705660439 0.708939171369765 0.432835820895522 0.347557183161083 0.521149145857349 6.00934633794543 3.90839428169284 9.34284751286563 1.6342648966017e-17 9 4975 True False 9.43254703090845 7.17963930098335 12.4975317786564 0.00620188195038494 0.00471261838396347 0.00801008640653377 0.997871446576109 0.997336511761874 0.998322586648195 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 48 29 19 98 39 6462 26466 0.0149390243902439 0.0121444194641604 0.0181760718321121 0.998528579513299 0.997989063008624 0.998953473433816 0.715328467153284 0.631994755902539 0.789101294187584 0.604166666666666 0.452695800910679 0.742301027153591 0.426470588235294 0.307226086304429 0.552328203311738 6.25123393441821 3.38495932272663 11.8022567472754 6.90968977093244e-10 10 4087 True False 0 0 0 0 0 0 0 10.2915982191748 7.0249159176814 15.339853148368 0.00446772454167308 0.00299408554304516 0.00641014340180208 0.998528579513299 0.997989063008624 0.998953473433816 93 Assoc w R 1) Assoc w R No change yes 1 +Ethambutol embB p.Gly406Val embB_p.Gly406Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3584 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly443Ser embB_p.Gly443Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 146.529978407112 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 157.179059039538 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly458Cys embB_p.Gly458Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3544 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2925 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly459Ser embB_p.Gly459Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly474Asp embB_p.Gly474Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly535Ser embB_p.Gly535Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly542Ser embB_p.Gly542Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Gly580Ser embB_p.Gly580Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 3 9480 35702 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99991597815432 0.999754472342108 0.99998267234027 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.0610057960224 1 2818.5 4975 False False 1.25534458509142 0.0239099774609589 15.6346568618898 0 0 0.00038904660702099 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2943 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly603Ala embB_p.Gly603Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3502 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2887 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly603Arg embB_p.Gly603Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 4 10 9477 35695 0.000421896424427802 0.000114964157806894 0.00107986688593449 0.999719927181067 0.999484996631079 0.999865686288203 0.285714285714285 0.0838893183071275 0.581035257183661 0 0 0.707598226178713 0 0 0.30849710781876 0 0 9.11758920620298 1 1480 4975 False False 1.50659491400232 0.3448246436219 5.2248765690981 0 0 0.000389169738041761 0.999719927181067 0.999484996631079 0.999865686288203 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.77947080093164 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 2 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly62Arg embB_p.Gly62Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly65Asp embB_p.Gly65Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly65Ser embB_p.Gly65Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly665Arg embB_p.Gly665Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly665Trp embB_p.Gly665Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12104088004766 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly694Asp embB_p.Gly694Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly696Ala embB_p.Gly696Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly696Arg embB_p.Gly696Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly696Glu embB_p.Gly696Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3509 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2893 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Gly745Ala embB_p.Gly745Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly745Arg embB_p.Gly745Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly748Arg embB_p.Gly748Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Gly748Glu embB_p.Gly748Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly792Ser embB_p.Gly792Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Gly810Ala embB_p.Gly810Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Gly825Asp embB_p.Gly825Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3520 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly825Ser embB_p.Gly825Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Gly836Arg embB_p.Gly836Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 13 9481 35692 0 0 0.00038900558066021 0.999635905335387 0.999377467513205 0.999806121137399 0 0 0.24705263800047 0 0 0.707598226178713 0 0 0.24705263800047 0 0 9.11297732904211 1 1480 4975 False False 0 0 1.2354962611609 0 0 0.00038900558066021 0.999635905335387 0.999377467513205 0.999806121137399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 12 6560 26493 0 0 0.000562171107654053 0.999547255234861 0.999209279704825 0.999766038988972 0 0 0.264648469397051 0 0 0.707598226178713 0 0 0.264648469397051 0 0 9.776519729618 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 1.45386850159099 0 0 0.000562171107654053 0.999547255234861 0.999209279704825 0.999766038988972 3 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly836Glu embB_p.Gly836Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly846Ser embB_p.Gly846Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly851Asp embB_p.Gly851Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly851Val embB_p.Gly851Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12104088004766 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly871Val embB_p.Gly871Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Gly891Glu embB_p.Gly891Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly895Arg embB_p.Gly895Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Gly914Arg embB_p.Gly914Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3545 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2926 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly923Glu embB_p.Gly923Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly96Glu embB_p.Gly96Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly979Ala embB_p.Gly979Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0615661524565 1 2818.5 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Gly979Asp embB_p.Gly979Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3669 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3026 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.His1002Arg embB_p.His1002Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 39 12 27 31 34 9450 35671 0.00326969728931547 0.00222264895937465 0.00463789095997725 0.999047752415628 0.998669581250379 0.999340453530361 0.476923076923076 0.35145968076083 0.604557538571586 0.307692307692307 0.170195902964694 0.475691391541684 0.260869565217391 0.14266853688823 0.411318847604362 1.67764844209288 0.77390744779092 3.42636663043223 0.165070263525338 159 4975 False False 3.44164643635231 2.04435058542345 5.77385083969805 0.00126823081800887 0.000655479651163647 0.00221429494516584 0.999047752415628 0.998669581250379 0.999340453530361 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 27 9 18 23 24 6537 26481 0.00350609756097561 0.0022238236869373 0.00525625089693 0.999094510469722 0.998653000996664 0.999419752318005 0.489361702127659 0.340756964834897 0.639355296615258 0.333333333333333 0.165188179687315 0.539607286092257 0.272727272727272 0.132996388710814 0.455238427760781 2.02547039926571 0.801175970887081 4.75086632752691 0.0896655913187047 94 4087 False False 0 0 0 0 0 0 0 3.88215159859262 2.09236760347658 7.18621088867056 0.00137488542621448 0.000628871811821267 0.00260834921425096 0.999094510469722 0.998653000996664 0.999419752318005 21 3) Uncertain significance No change no 1 +Ethambutol embB p.His154Arg embB_p.His154Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.His342Asn embB_p.His342Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.His687Tyr embB_p.His687Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.His872Tyr embB_p.His872Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.His890Arg embB_p.His890Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 0 9 9481 35696 0 0 0.00038900558066021 0.99974793446296 0.999521555266748 0.999884733314884 0 0 0.336267116879942 0 0 0.369416647552819 0 0 0.336267116879942 0 0 2.20617932491131 0.217678555618335 224 4975 False False 0 0 1.90786321657339 0 0 0.00038900558066021 0.99974793446296 0.999521555266748 0.999884733314884 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 8 6560 26497 0 0 0.000562171107654053 0.999698170156574 0.999405361976814 0.999869682578628 0 0 0.369416647552819 0 0 0.409616397225003 0 0 0.369416647552819 0 0 2.80317025491206 0.357904627019103 207 4087 False False 0 0 0 0 0 0 0 0 0 2.36695385477914 0 0 0.000562171107654053 0.999698170156574 0.999405361976814 0.999869682578628 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ile1006Met embB_p.Ile1006Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.10982832991351 0.590980565810755 492 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.40943166615857 0.590385352956204 278 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ile1009Leu embB_p.Ile1009Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.096562813829025 Inf 0.209821626167397 198.5 4975 False False Inf 0.096562813829025 Inf 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Ile1039Met embB_p.Ile1039Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.19822685561766 0.354697857676227 290 4975 False False 0 0 3.19822685561766 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 6560 26499 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.43165838346939 0.605981932438924 311.5 4087 False False 0 0 0 0 0 0 0 0 0 3.43165838346939 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ile16Leu embB_p.Ile16Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 9480 35702 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99991597815432 0.999754472342108 0.99998267234027 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11649128277037 1 2818.5 4975 False False 1.25534458509142 0.0239099774609589 15.6346568618898 0 0 0.00038904660702099 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 3 6559 26502 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999886813808715 0.999669257903365 0.999976657677988 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.78133043653875 1 2276.5 4087 False False 0 0 0 0 0 0 0 1.34685165421558 0.025651688752077 16.7753654027497 0 0 0.000562256793434776 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ile206Ser embB_p.Ile206Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3510 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2894 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Ile226Val embB_p.Ile226Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ile284Leu embB_p.Ile284Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ile303Leu embB_p.Ile303Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3712 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3063 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Ile303Met embB_p.Ile303Met 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3521 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2904 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ile32Thr embB_p.Ile32Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 1 5 9480 35700 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999859963590533 0.999673232250017 0.999954529045718 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.602364635616474 0 0 0.521823750104981 0 0 5.70559538331064 0.585903624207148 445 4975 False False 0.753164556962025 0.0159260191955521 6.73154939272228 0 0 0.00038904660702099 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 3 6559 26502 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999886813808715 0.999669257903365 0.999976657677988 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.78133043653875 1 2276.5 4087 False False 0 0 0 0 0 0 0 1.34685165421558 0.025651688752077 16.7753654027497 0 0 0.000562256793434776 0.999886813808715 0.999669257903365 0.999976657677988 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Ile450Leu embB_p.Ile450Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 0 9477 35705 0.000421896424427802 0.000114964157806894 0.00107986688593449 1 0.999896689850119 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3511 4975 False False Inf 2.4863933079676 Inf 0 0 0.000389169738041761 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2895 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ile450Met embB_p.Ile450Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.096562813829025 Inf 0.209821626167397 198.5 4975 False False Inf 0.096562813829025 Inf 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.103599830448027 Inf 0.198397096627854 142 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Ile450Ser embB_p.Ile450Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Ile465Ser embB_p.Ile465Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3564 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2944 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Ile489Met embB_p.Ile489Met 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3602 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2969 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Ile489Thr embB_p.Ile489Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 2 7 3 12 9478 35693 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.99966391261728 0.999412996653316 0.999826327071809 0.2 0.0433120051058366 0.480891133806853 0.222222222222222 0.0281449734778982 0.600093573716312 0.142857142857142 0.0177945154831915 0.428129160909698 1.07596539354294 0.109027128621274 5.65127820634042 1 2818.5 4975 False False 0.941469719350073 0.170450014516211 3.48957054566882 0.000210970464135021 2.55505231929967e-05 0.00076188787765788 0.99966391261728 0.999412996653316 0.999826327071809 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 2 7 2 11 6558 26494 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999584983965289 0.999257543293353 0.999792807866341 0.153846153846153 0.0192066719825284 0.454471055676557 0.222222222222222 0.0281449734778982 0.600093573716312 0.153846153846153 0.0192066719825284 0.454471055676557 1.15427177275301 0.116948539482202 6.06432422741309 0.695621050169485 331 4087 False False 0 0 0 0 0 0 0 0.73453658266101 0.0790946916112532 3.36686446774636 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999584983965289 0.999257543293353 0.999792807866341 2 3) Uncertain significance No change no 1 +Ethambutol embB p.Ile545Met embB_p.Ile545Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ile545Phe embB_p.Ile545Phe 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3611 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ile556Val embB_p.Ile556Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ile563Leu embB_p.Ile563Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 15 2 13 21 19 9460 35686 0.00221495622824596 0.00137159943312054 0.00338381350894567 0.999467861644027 0.999169124220115 0.999679588507228 0.525 0.361280135264062 0.684880293365014 0.133333333333333 0.0165759134400836 0.404602696603372 0.0952380952380952 0.0117493178844458 0.303774406913924 0.580354529191738 0.0635723267356125 2.56432587212172 0.750856980697021 536 4975 False False 4.16938911761433 2.13272751401785 8.20270196609406 0.000211371803001479 2.55991310809817e-05 0.000763336852032595 0.999467861644027 0.999169124220115 0.999679588507228 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 1 3 7 7 6553 26498 0.0010670731707317 0.000429122972600259 0.00219733487653492 0.999735898887002 0.999455926960675 0.999893811273379 0.5 0.230360541448062 0.769639458551937 0.25 0.00630946320970987 0.805879550316756 0.125 0.0031597235312519 0.526509670875206 1.34788137748613 0.0256712970606718 16.788195310397 0.586875543963358 248 4087 False False 0 0 0 0 0 0 0 4.04364413245841 1.20976512255512 13.5148296780423 0.000152578577967653 3.86294767829945e-06 0.000849816992931799 0.999735898887002 0.999455926960675 0.999893811273379 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ile666Thr embB_p.Ile666Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Ile709Thr embB_p.Ile709Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 14 0 14 0 14 9481 35691 0 0 0.00038900558066021 0.999607898053494 0.999342206985133 0.999785618166341 0 0 0.231635761650116 0 0 0.231635761650116 0 0 0.231635761650116 0 0 1.13511057396106 0.0520839153551087 96 4975 False False 0 0 1.13511057396106 0 0 0.00038900558066021 0.999607898053494 0.999342206985133 0.999785618166341 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 13 0 13 0 13 6560 26492 0 0 0.000562171107654053 0.999509526504433 0.999161421428146 0.999738818498366 0 0 0.24705263800047 0 0 0.24705263800047 0 0 0.24705263800047 0 0 1.32548813951656 0.0853074354316813 84.5 4087 False False 0 0 0 0 0 0 0 0 0 1.32548813951656 0 0 0.000562171107654053 0.999509526504433 0.999161421428146 0.999738818498366 3 3) Uncertain significance No change no 1 +Ethambutol embB p.Ile709Val embB_p.Ile709Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3618 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2981 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Ile883Val embB_p.Ile883Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Leu1036Val embB_p.Leu1036Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3576 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2950 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Leu1037Ile embB_p.Leu1037Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.19822685561766 0.354697857676227 290 4975 False False 0 0 3.19822685561766 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12104088004766 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Leu1053Val embB_p.Leu1053Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Leu1070Pro embB_p.Leu1070Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3537 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2919 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Leu17Trp embB_p.Leu17Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.058895521352 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 2 3) Uncertain significance No change no 1 +Ethambutol embB p.Leu239Arg embB_p.Leu239Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Leu239Pro embB_p.Leu239Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3503 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2888 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Leu253Arg embB_p.Leu253Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Leu253Ile embB_p.Leu253Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Leu304_Gly305insVal embB_p.Leu304_Gly305insVal 1 inframe_insertion (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3619 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2982 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Leu304dup embB_p.Leu304dup 1 inframe_insertion (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3577 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2951 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Leu348Pro embB_p.Leu348Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Leu359Ile embB_p.Leu359Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3598 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Ethambutol embB p.Leu370Arg embB_p.Leu370Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 25 0 25 1 25 9480 35680 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999299817952667 0.998966565499085 0.999546829455204 0.0384615384615384 0.00097328789333503 0.196369646762539 0 0 0.137185171530712 0 0 0.137185171530712 0 0 0.598568980940634 0.00513788480181243 45 4975 False False 0.150548523206751 0.00367011474722141 0.919963110620938 0 0 0.00038904660702099 0.999299817952667 0.998966565499085 0.999546829455204 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 20 0 20 0 20 6560 26485 0 0 0.000562171107654053 0.999245425391435 0.998834860097994 0.999539027227828 0 0 0.168433470983085 0 0 0.168433470983085 0 0 0.168433470983085 0 0 0.818043220340071 0.021422745329194 50 4087 False False 0 0 0 0 0 0 0 0 0 0.818043220340071 0 0 0.000562171107654053 0.999245425391435 0.998834860097994 0.999539027227828 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Leu402Val embB_p.Leu402Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 19 6 13 27 23 9454 35682 0.00284780086488767 0.00187753180356821 0.00414071599883961 0.999355832516454 0.999033588308985 0.99959161063274 0.54 0.393241976116921 0.681850821431391 0.31578947368421 0.125760635872983 0.56550156884615 0.206896551724137 0.0799418488760801 0.397246949227239 1.74197327952352 0.542778428646527 4.91340475619229 0.260605967345087 259 4975 False False 4.43067116748374 2.44476687014178 8.09065748413608 0.000634249471458773 0.000232792809744496 0.00137997904373822 0.999355832516454 0.999033588308985 0.99959161063274 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 15 4 11 24 19 6536 26486 0.00365853658536585 0.0023454571752643 0.00543875250351798 0.999283154121863 0.998880781714398 0.999568358524102 0.55813953488372 0.398753864608481 0.709218822118935 0.266666666666666 0.0778715462910436 0.551003241036971 0.17391304347826 0.0495076453057934 0.387811889954797 1.47357293868921 0.342098404171468 4.97501792820227 0.516007793878133 244 4087 False False 0 0 0 0 0 0 0 5.11872705018359 2.68550897360984 9.88934442105557 0.000611620795107033 0.000166670423850362 0.0015652450188148 0.999283154121863 0.998880781714398 0.999568358524102 19 3) Uncertain significance No change no 1 +Ethambutol embB p.Leu410Pro embB_p.Leu410Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3603 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2970 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Leu466Ser embB_p.Leu466Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3585 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2957 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Leu472Val embB_p.Leu472Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3504 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2889 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Leu47Arg embB_p.Leu47Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Leu499Pro embB_p.Leu499Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3713 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3064 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Leu544Trp embB_p.Leu544Trp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3546 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2927 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Leu558Phe embB_p.Leu558Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Leu613_Val614dup embB_p.Leu613_Val614dup 1 inframe_insertion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Leu629Pro embB_p.Leu629Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.096562813829025 Inf 0.209821626167397 198.5 4975 False False Inf 0.096562813829025 Inf 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Leu632Phe embB_p.Leu632Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 5 9480 35700 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999859963590533 0.999673232250017 0.999954529045718 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.841886116991581 0 0 0.521823750104981 0 0 20.0598850836259 1 2818.5 4975 False False 0.753164556962025 0.0159260191955521 6.73154939272228 0 0 0.00038904660702099 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 4 6559 26501 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999849085078287 0.999613643356053 0.999958879281354 0.2 0.00505076337946806 0.716417936118089 0 0 0.841886116991581 0 0 0.602364635616474 0 0 21.51979849085 1 2276.5 4087 False False 0 0 0 0 0 0 0 1.01010062509528 0.0205075656450505 10.2127021503241 0 0 0.000562256793434776 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Leu632Ser embB_p.Leu632Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3633 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Leu638Ser embB_p.Leu638Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Leu638Trp embB_p.Leu638Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Leu74Arg embB_p.Leu74Arg 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 0 1 21 8 9460 35697 0.00221495622824596 0.00137159943312054 0.00338381350894567 0.999775941744853 0.999558563909973 0.999903262744512 0.724137931034482 0.527615517569966 0.872659885897769 0 0 0.975 0 0 0.369416647552819 0 0 146.833991042676 1 2818.5 4975 False False 9.90535147991543 4.21283171253719 25.8622248494405 0 0 0.000389868955347791 0.999775941744853 0.999558563909973 0.999903262744512 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 19 6 6541 26499 0.00289634146341463 0.00174465970818583 0.00451931679095641 0.99977362761743 0.99950734823901 0.999916920939814 0.76 0.548711982183313 0.906435560668257 NA NA NA 0 0 0.4592581264399 NA NA NA NA 2983 4087 False False 0 0 0 0 0 0 0 12.8288487998776 4.92277763600422 39.216944320696 0 0 0.000563803616355508 0.99977362761743 0.99950734823901 0.999916920939814 2 Assoc w RI 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Ethambutol embB p.Leu74Pro embB_p.Leu74Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 2 1 3 1 9478 35704 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999971992718106 0.999843963402622 0.999999290917266 0.75 0.194120449683243 0.99369053679029 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 7.53407891960329 0.392161721905024 443.194232299038 0.113576717466983 131.5 4975 False False 11.3011183794049 0.90722384791697 591.183089908516 0.000210970464135021 2.55505231929967e-05 0.00076188787765788 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Leu777Val embB_p.Leu777Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Leu874_Val875insAlaLeu embB_p.Leu874_Val875insAlaLeu 1 inframe_insertion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Leu953Met embB_p.Leu953Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Leu971Val embB_p.Leu971Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 0 9 9481 35696 0 0 0.00038900558066021 0.99974793446296 0.999521555266748 0.999884733314884 0 0 0.336267116879942 0 0 0.369416647552819 0 0 0.336267116879942 0 0 2.20617932491131 0.217678555618335 224 4975 False False 0 0 1.90786321657339 0 0 0.00038900558066021 0.99974793446296 0.999521555266748 0.999884733314884 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 7 6560 26498 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 3.43152889101174 0.605984763142217 320.5 4087 False False 0 0 0 0 0 0 0 0 0 2.80327602229365 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Leu974Met embB_p.Leu974Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Leu974Val embB_p.Leu974Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3655 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3015 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Lys1011Glu embB_p.Lys1011Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3714 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Lys1011Thr embB_p.Lys1011Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3620 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2984 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Lys1022Thr embB_p.Lys1022Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3522 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2905 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Lys107Arg embB_p.Lys107Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3512 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2896 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Lys107Glu embB_p.Lys107Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Lys165Asn embB_p.Lys165Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 9478 35705 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 1 0.999896689850119 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3565 4975 False False Inf 1.55639137151076 Inf 0 0 0.000389128685709026 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2945 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Lys218Asn embB_p.Lys218Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Lys381Gln embB_p.Lys381Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Lys561Arg embB_p.Lys561Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 23 0 23 0 28 9481 35677 0 0 0.00038900558066021 0.999215796106988 0.998866804929334 0.999478840936165 0 0 0.123436118500263 0 0 0.148185128915224 0 0 0.123436118500263 0 0 0.654787285802108 0.00814948485346022 54 4975 False False 0 0 0.530020139481571 0 0 0.00038900558066021 0.999215796106988 0.998866804929334 0.999478840936165 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 15 0 15 0 19 6560 26486 0 0 0.000562171107654053 0.999283154121863 0.998880781714398 0.999568358524102 0 0 0.176466911806965 0 0 0.218019360910534 0 0 0.176466911806965 0 0 1.12603236980982 0.0534963061176043 69 4087 False False 0 0 0 0 0 0 0 0 0 0.865443021143955 0 0 0.000562171107654053 0.999283154121863 0.998880781714398 0.999568358524102 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Lys561Asn embB_p.Lys561Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3686 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3040 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Lys561Met embB_p.Lys561Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3523 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 2906 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 4 3) Uncertain significance No change no 1 +Ethambutol embB p.Lys662Glu embB_p.Lys662Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Lys662Thr embB_p.Lys662Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Lys765Asn embB_p.Lys765Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Lys820Thr embB_p.Lys820Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3689 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3042 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Lys882Glu embB_p.Lys882Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Lys927Arg embB_p.Lys927Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Lys927Glu embB_p.Lys927Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Lys938Asn embB_p.Lys938Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Met1000Arg embB_p.Met1000Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 2 2 9 2 9472 35703 0.000949266954962556 0.000434154257137837 0.00180123610483098 0.999943985436213 0.999797670939776 0.99999321630447 0.818181818181818 0.482244147639827 0.97716880170004 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 3.76932010135135 0.273172644964659 51.9848785690873 0.195867053626311 161 4975 False False 16.961940456081 3.50967708202642 161.186342183967 0.000211104074308634 2.55667052988578e-05 0.000762370257516042 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 6 1 6554 26504 0.000914634146341463 0.000335726224038477 0.00198970246660848 0.999962271269571 0.999789807096406 0.999999044791703 0.857142857142857 0.421276802956804 0.996389703138099 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 4.04394263045468 0.0515094227689547 316.621180886842 0.357243215108619 184 4087 False False 0 0 0 0 0 0 0 24.2636557827281 2.94261876829579 1109.3554133557 0.00015255530129672 3.86235836629056e-06 0.000849687394050823 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Met265Ile embB_p.Met265Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 146.525883667094 1 2818.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 157.173142990263 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Met306Ile embB_p.Met306Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1915 1043 872 1953 1159 7528 34546 0.205990929226874 0.197888835750244 0.214274040047472 0.967539560285674 0.9656488979585 0.969353663517158 0.627570694087403 0.610310834629869 0.644590407613603 0.544647519582245 0.522027733394758 0.567130366289681 0.473660308810172 0.452625279800264 0.494765528193675 5.48890838118729 4.99395425603882 6.03278378463946 3.28014428395086e-267 2 4975 True False 7.73280334378916 7.15524817551321 8.35793622598949 0.121689417804223 0.114839305412665 0.12879783193207 0.967539560285674 0.9656488979585 0.969353663517158 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 1177 720 457 1360 611 5200 25894 0.207317073170731 0.197562747239855 0.217332260222209 0.976947745708357 0.975069062046435 0.978720836180991 0.690005073566717 0.669062028032472 0.710381371498973 0.611724723874256 0.583206387436325 0.639683241429974 0.540946656649136 0.513734269370169 0.567977869963188 7.8453459013634 6.94048593062534 8.87535008375898 1.89041944033969e-243 2 4087 True False 0 0 0 0 0 0 0 11.083922951026 10.0206371310341 12.2672935954857 0.121621621621621 0.113399160673871 0.130218924984521 0.976947745708357 0.975069062046435 0.978720836180991 922 Assoc w R 1) Assoc w R No change yes 1 +Ethambutol embB p.Met306Leu embB_p.Met306Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 98 69 29 145 50 9336 35655 0.0152937453855078 0.0129205939129316 0.0179710660624496 0.998599635905335 0.998154206154326 0.998960449649607 0.743589743589743 0.676310453100606 0.803303807966354 0.704081632653061 0.603380426314403 0.792050286101026 0.579831932773109 0.48589745716815 0.669696458836152 9.08679416718376 5.80666051666257 14.5564278624362 7.2598956150336e-26 7 4975 True False 11.075353470437 7.97262327431919 15.6120359800822 0.00733652312599681 0.00571260718378771 0.00927578450758481 0.998599635905335 0.998154206154326 0.998960449649607 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 70 50 20 99 37 6461 26468 0.0150914634146341 0.0122820711467651 0.0183430880851781 0.998604036974155 0.998076357089741 0.999016928650496 0.727941176470588 0.645017071133736 0.800660639368295 0.714285714285714 0.59378220158117 0.815954391426665 0.57471264367816 0.4640657682467 0.68012540064778 10.2414486921529 5.98319636092829 18.1717087621935 1.11599952451295e-20 7 4087 True False 0 0 0 0 0 0 0 10.9611180597096 7.43470434586753 16.4646902495419 0.00767931193365074 0.00570495072930897 0.0101118263284482 0.998604036974155 0.998076357089741 0.999016928650496 77 Assoc w R 1) Assoc w R No change yes 1 +Ethambutol embB p.Met306Thr embB_p.Met306Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 1 9478 35704 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999971992718106 0.999843963402622 0.999999290917266 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 3656 4975 False False 11.3011183794049 0.90722384791697 591.183089908516 0 0 0.000389128685709026 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3016 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 2 3) Uncertain significance No change no 1 +Ethambutol embB p.Met306Val embB_p.Met306Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2658 2125 533 3245 685 6236 35020 0.342263474317055 0.332709872028954 0.351914071429226 0.980815011903094 0.979338413613011 0.982212649501428 0.825699745547073 0.813470907345898 0.837442240483999 0.799473288186606 0.78373746061429 0.814546656821879 0.756227758007117 0.739912870713119 0.772007286444129 22.3893641832752 20.2803011846344 24.767191242766 0 1 4975 True False 26.6032174845376 24.3816638037971 29.0675472076101 0.254156201411314 0.244850951694233 0.263633070364675 0.980815011903094 0.979338413613011 0.982212649501428 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 1917 1601 316 2297 393 4263 26112 0.35015243902439 0.338601632619479 0.361836597864967 0.985172608941709 0.983644324520702 0.986593129282058 0.853903345724907 0.839985496693624 0.867046081363698 0.835159102764736 0.81777907624398 0.851506949737409 0.802908726178535 0.784757654563651 0.820164472664125 31.0333781701244 27.3400105511995 35.3010885576625 0 1 4087 True False 0 0 0 0 0 0 0 35.8008426850603 32.0021978056078 40.1596078991902 0.273021828103683 0.26164896653891 0.284620908893361 0.985172608941709 0.983644324520702 0.986593129282058 1501 Assoc w R 1) Assoc w R No change yes 1 +Ethambutol embB p.Met316Val embB_p.Met316Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Met340Ile embB_p.Met340Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.11527461591697 1 2818.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 21.5173342675905 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Met350Thr embB_p.Met350Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Met389Ile embB_p.Met389Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3664 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3022 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Met389Val embB_p.Met389Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Met396Ile embB_p.Met396Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 1 4 3 5 9478 35700 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999859963590533 0.999673232250017 0.999954529045718 0.375 0.0852334141372535 0.755136783633448 0.2 0.00505076337946806 0.716417936118089 0.166666666666666 0.00421074451448947 0.641234578997674 0.941654357459379 0.0191188126393873 9.51478321594336 1 2818.5 4975 False False 2.25997045790251 0.350887762500293 11.6204549580208 0.000105496360375567 2.67093302808208e-06 0.000587646375974446 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 2 3 6558 26502 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999886813808715 0.999669257903365 0.999976657677988 0.4 0.0527449505263169 0.853367200365326 0 0 0.841886116991581 0 0 0.707598226178713 0 0 21.5238846974293 1 1103 4087 False False 0 0 0 0 0 0 0 2.69411405916437 0.224966079471659 23.5225659748306 0 0 0.00056234250533983 0.999886813808715 0.999669257903365 0.999976657677988 2 3) Uncertain significance No change no 1 +Ethambutol embB p.Met423Ile embB_p.Met423Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 4 9480 35701 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999887970872426 0.999713186009257 0.999969475016731 0.2 0.00505076337946806 0.716417936118089 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.11623600185219 1 1480 4975 False False 0.941482067510548 0.0191153149568561 9.51304376083015 0 0 0.00038904660702099 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 4 6559 26501 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999849085078287 0.999613643356053 0.999958879281354 0.2 0.00505076337946806 0.716417936118089 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.780961496544 1 2276.5 4087 False False 0 0 0 0 0 0 0 1.01010062509528 0.0205075656450505 10.2127021503241 0 0 0.000562256793434776 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Met423Thr embB_p.Met423Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 15 1 9466 35704 0.00158211159160426 0.000885757734327454 0.00260811203671776 0.999971992718106 0.999843963402622 0.999999290917266 0.9375 0.697679261565468 0.998418888277234 NA NA NA 0 0 0.975 NA NA NA NA 3524 4975 False False 56.5772237481512 8.70195769859486 2351.81958361642 0 0 0.00038962188605047 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 15 1 6545 26504 0.00228658536585365 0.0012803316536391 0.00376857487312357 0.999962271269571 0.999789807096406 0.999999044791703 0.9375 0.697679261565468 0.998418888277234 NA NA NA 0 0 0.975 NA NA NA NA 2907 4087 False False 0 0 0 0 0 0 0 60.7425515660809 9.34109779088321 2522.19767872895 0 0 0.000563459142866522 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Met462Thr embB_p.Met462Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Met557Ile embB_p.Met557Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3525 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2908 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Met575Arg embB_p.Met575Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Met575Val embB_p.Met575Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Met586Val embB_p.Met586Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Met606Ile embB_p.Met606Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3657 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3017 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Met626Val embB_p.Met626Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3700 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Met660Arg embB_p.Met660Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Met714Ile embB_p.Met714Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Met764Leu embB_p.Met764Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Met804Ile embB_p.Met804Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3646 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3006 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Met904Ile embB_p.Met904Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3586 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2958 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Met916Thr embB_p.Met916Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Met91Ile embB_p.Met91Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3532 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2915 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Met91Thr embB_p.Met91Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3505 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2890 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Met939Ile embB_p.Met939Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Met939Val embB_p.Met939Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3604 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Phe1012Leu embB_p.Phe1012Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 13 0 13 0 16 9481 35689 0 0 0.00038900558066021 0.999551883489707 0.999272388596077 0.99974384169233 0 0 0.205907214207822 0 0 0.24705263800047 0 0 0.205907214207822 0 0 1.23539240318249 0.0841532311692013 123.5 4975 False False 0 0 0.976295497466411 0 0 0.00038900558066021 0.999551883489707 0.999272388596077 0.99974384169233 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 13 0 13 0 16 6560 26489 0 0 0.000562171107654053 0.999396340313148 0.99901987910474 0.999654918214049 0 0 0.205907214207822 0 0 0.24705263800047 0 0 0.205907214207822 0 0 1.32533805387628 0.0853030776503869 80.5 4087 False False 0 0 0 0 0 0 0 0 0 1.047384092264 0 0 0.000562171107654053 0.999396340313148 0.99901987910474 0.999654918214049 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Phe1067Leu embB_p.Phe1067Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3621 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2985 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Phe161Leu embB_p.Phe161Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Phe176Leu embB_p.Phe176Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Phe256Leu embB_p.Phe256Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3640 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3000 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Phe285Leu embB_p.Phe285Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 9 9481 35696 0 0 0.00038900558066021 0.99974793446296 0.999521555266748 0.999884733314884 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 3704 4975 False False 0 0 1.90786321657339 0 0 0.00038900558066021 0.99974793446296 0.999521555266748 0.999884733314884 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 8 6560 26497 0 0 0.000562171107654053 0.999698170156574 0.999405361976814 0.999869682578628 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 3055 4087 False False 0 0 0 0 0 0 0 0 0 2.36695385477914 0 0 0.000562171107654053 0.999698170156574 0.999405361976814 0.999869682578628 3 3) Uncertain significance No change no 1 +Ethambutol embB p.Phe285Val embB_p.Phe285Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3670 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3027 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Phe320Cys embB_p.Phe320Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3587 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2959 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Phe323Leu embB_p.Phe323Leu 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 0 1 2 1 9479 35704 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999971992718106 0.999843963402622 0.999999290917266 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 146.569015564619 1 2818.5 4975 False False 7.53328410169849 0.392120325718966 443.147628387906 0 0 0.000389087642036349 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 0 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 157.21479794295 1 1103 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Phe330Ile embB_p.Phe330Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Phe330Leu embB_p.Phe330Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 5 2 9476 35703 0.000527370530534753 0.000171257241502832 0.00123027414547083 0.999943985436213 0.999797670939776 0.99999321630447 0.714285714285714 0.290420863737342 0.963307433823914 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3551 4975 False False 9.4193224989447 1.54161474423025 98.9467001652174 0 0 0.000389210799037296 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 5 1 6555 26504 0.000762195121951219 0.000247527523788107 0.00177780526826415 0.999962271269571 0.999789807096406 0.999999044791703 0.833333333333333 0.358765421002325 0.99578925548551 NA NA NA 0 0 0.975 NA NA NA NA 2930 4087 False False 0 0 0 0 0 0 0 20.2166285278413 2.26137738039683 951.169010205643 0 0 0.00056259979792051 0.999962271269571 0.999789807096406 0.999999044791703 2 3) Uncertain significance No change no 1 +Ethambutol embB p.Phe330Ser embB_p.Phe330Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 5 2 9476 35703 0.000527370530534753 0.000171257241502832 0.00123027414547083 0.999943985436213 0.999797670939776 0.99999321630447 0.714285714285714 0.290420863737342 0.963307433823914 1 0.158113883008419 1 0.5 0.067585986488543 0.932414013511457 Inf 0.707498195257301 Inf 0.0440033275631235 85 4975 False False 9.4193224989447 1.54161474423025 98.9467001652174 0.000211014982063726 2.55559149517483e-05 0.000762048603103055 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 3 0 6557 26505 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 1 0.999860832946126 1 1 0.292401773821286 1 1 0.025 1 1 0.025 1 Inf 0.103631425446323 Inf 0.198348607204427 126 4087 False False 0 0 0 0 0 0 0 Inf 1.66990152933523 Inf 0.000152485513876181 3.86059150860036e-06 0.000849298834468653 1 0.999860832946126 1 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Phe330Val embB_p.Phe330Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 9478 35705 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 1 0.999896689850119 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3566 4975 False False Inf 1.55639137151076 Inf 0 0 0.000389128685709026 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2946 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Phe398Cys embB_p.Phe398Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3526 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2909 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Phe398Leu embB_p.Phe398Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Phe440Ser embB_p.Phe440Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Phe494Leu embB_p.Phe494Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Phe541Val embB_p.Phe541Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3538 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2920 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Phe579Ser embB_p.Phe579Ser 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.096562813829025 Inf 0.209821626167397 198.5 4975 False False Inf 0.096562813829025 Inf 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.103599830448027 Inf 0.198397096627854 142 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Phe579Val embB_p.Phe579Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Phe584Leu embB_p.Phe584Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Phe628Ser embB_p.Phe628Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3612 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2976 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Phe676Ser embB_p.Phe676Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Phe688Cys embB_p.Phe688Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Phe688Val embB_p.Phe688Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3676 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Phe743Leu embB_p.Phe743Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Phe763Leu embB_p.Phe763Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Phe763Val embB_p.Phe763Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Phe79Leu embB_p.Phe79Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Phe994Val embB_p.Phe994Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Pro103His embB_p.Pro103His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Pro103Thr embB_p.Pro103Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 0 9 9481 35696 0 0 0.00038900558066021 0.99974793446296 0.999521555266748 0.999884733314884 0 0 0.336267116879942 0 0 0.369416647552819 0 0 0.336267116879942 0 0 2.20617932491131 0.217678555618335 224 4975 False False 0 0 1.90786321657339 0 0 0.00038900558066021 0.99974793446296 0.999521555266748 0.999884733314884 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 0 9 6560 26496 0 0 0.000562171107654053 0.999660441426146 0.999355510362951 0.999844720818052 0 0 0.336267116879942 0 0 0.369416647552819 0 0 0.336267116879942 0 0 2.3668645343219 0.369990583605676 229.5 4087 False False 0 0 0 0 0 0 0 0 0 2.04691100627475 0 0 0.000562171107654053 0.999660441426146 0.999355510362951 0.999844720818052 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Pro1075Leu embB_p.Pro1075Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Pro1091Gln embB_p.Pro1091Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Pro1098Arg embB_p.Pro1098Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Pro12Gln embB_p.Pro12Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3690 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3043 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Pro12Leu embB_p.Pro12Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Pro12Ser embB_p.Pro12Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Pro136Ala embB_p.Pro136Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Pro136Ser embB_p.Pro136Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 5.70499352101301 0.585896604883905 379.5 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.77947080093164 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Pro143Ser embB_p.Pro143Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Pro167Arg embB_p.Pro167Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 12 6 9469 35699 0.0012656892732834 0.000654165731961641 0.0022098595784263 0.99983195630864 0.999634275787128 0.999938328510354 0.666666666666666 0.409925238172074 0.866572597493876 0 0 0.841886116991581 0 0 0.4592581264399 0 0 20.0825653430266 1 2818.5 4975 False False 7.54018375752455 2.61808559897166 24.4903205036172 0 0 0.00038949846879491 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 12 5 6548 26500 0.00182926829268292 0.000945555636841848 0.00319318105848117 0.999811356347858 0.999559824020536 0.9999387451734 0.705882352941176 0.440417281245662 0.89686448562968 0 0 0.975 0 0 0.521823750104981 0 0 157.454546230985 1 2276.5 4087 False False 0 0 0 0 0 0 0 9.7128894318876 3.18352602005178 35.2103980224089 0 0 0.000563201063861023 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Pro177Leu embB_p.Pro177Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3647 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3007 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Pro183Ser embB_p.Pro183Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Pro195His embB_p.Pro195His 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 1 8 9480 35697 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999775941744853 0.999558563909973 0.999903262744512 0.111111111111111 0.00280913674659921 0.482496514917337 0 0 0.4592581264399 0 0 0.369416647552819 0 0 3.19838522501953 0.354702325761204 299.5 4975 False False 0.47068829113924 0.010610026508271 3.51159115085171 0 0 0.00038904660702099 0.999775941744853 0.999558563909973 0.999903262744512 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 1 8 6559 26497 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999698170156574 0.999405361976814 0.999869682578628 0.111111111111111 0.00280913674659921 0.482496514917337 0 0 0.4592581264399 0 0 0.369416647552819 0 0 3.43192265523431 0.605976153142579 305.5 4087 False False 0 0 0 0 0 0 0 0.504974081414849 0.0113820510464553 3.76768363928727 0 0 0.000562256793434776 0.999698170156574 0.999405361976814 0.999869682578628 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Pro197Arg embB_p.Pro197Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0615661524565 1 2818.5 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 157.21479794295 1 1103 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Pro214Ala embB_p.Pro214Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 3.76624472573839 0.0479745002090283 294.932792118969 0.375621806809355 335.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 4.04085988717792 0.0514701624188962 316.380494544091 0.35743759524028 195 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Pro214Gln embB_p.Pro214Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3671 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3028 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Pro262Leu embB_p.Pro262Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3552 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2931 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Pro270Ala embB_p.Pro270Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Pro353Ser embB_p.Pro353Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Pro371Arg embB_p.Pro371Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3539 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2921 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Pro397Thr embB_p.Pro397Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3691 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3044 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Pro404Ala embB_p.Pro404Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 3 9478 35702 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.99991597815432 0.999754472342108 0.99998267234027 0.5 0.118117248757025 0.881882751242974 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3605 4975 False False 3.76682844481958 0.504418797674528 28.1425087484132 0 0 0.000389128685709026 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 6557 26505 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 1 0.999860832946126 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2971 4087 False False 0 0 0 0 0 0 0 Inf 1.66990152933523 Inf 0 0 0.000562428243381166 1 0.999860832946126 1 1 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Pro404Leu embB_p.Pro404Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3540 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2922 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Pro404Ser embB_p.Pro404Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 3 2 7 6 9474 35699 0.000738318742748655 0.00029689231210758 0.00152062336565454 0.99983195630864 0.999634275787128 0.999938328510354 0.538461538461538 0.251345482270303 0.807767558198712 0.6 0.146632799634673 0.947255049473683 0.333333333333333 0.0748546314196918 0.700704943791459 5.65215326155794 0.647338324972513 67.7703885988634 0.0656881633755133 105 4975 False False 4.39611920343396 1.26467210709305 15.8376646413424 0.000316555872111427 6.52861893156317e-05 0.000924829138064015 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 3 2 6 5 6554 26500 0.000914634146341463 0.000335726224038477 0.00198970246660848 0.999811356347858 0.999559824020536 0.9999387451734 0.545454545454545 0.233793597659345 0.832511905936292 0.6 0.146632799634673 0.947255049473683 0.375 0.0852334141372535 0.755136783633448 6.06499847421422 0.694560341242764 72.46436385583 0.0566409998359342 76 4087 False False 0 0 0 0 0 0 0 4.85199877937137 1.23324406616883 20.1025168964506 0.000457526307762696 9.4362864267782e-05 0.00133649811497591 0.999811356347858 0.999559824020536 0.9999387451734 2 3) Uncertain significance No change no 1 +Ethambutol embB p.Pro430Leu embB_p.Pro430Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Pro45Leu embB_p.Pro45Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Pro461Gln embB_p.Pro461Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Pro477Ala embB_p.Pro477Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Pro477Thr embB_p.Pro477Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3634 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Ethambutol embB p.Pro531His embB_p.Pro531His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Pro59Thr embB_p.Pro59Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Pro616Ser embB_p.Pro616Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3506 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2891 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Pro616Thr embB_p.Pro616Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Pro655Gln embB_p.Pro655Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3705 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3056 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Pro655Leu embB_p.Pro655Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Pro706Ser embB_p.Pro706Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3541 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2923 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Pro708Leu embB_p.Pro708Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Pro70Arg embB_p.Pro70Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 11 0 11 0 11 9481 35694 0 0 0.00038900558066021 0.999691919899173 0.999448826618347 0.999846197812 0 0 0.284914152918154 0 0 0.284914152918154 0 0 0.284914152918154 0 0 1.50034693324555 0.135454656941587 149.5 4975 False False 0 0 1.50034693324555 0 0 0.00038900558066021 0.999691919899173 0.999448826618347 0.999846197812 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 0 11 0 11 6560 26494 0 0 0.000562171107654053 0.999584983965289 0.999257543293353 0.999792807866341 0 0 0.284914152918154 0 0 0.284914152918154 0 0 0.284914152918154 0 0 1.60965686204705 0.13661861299788 105 4087 False False 0 0 0 0 0 0 0 0 0 1.60965686204705 0 0 0.000562171107654053 0.999584983965289 0.999257543293353 0.999792807866341 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Pro731Leu embB_p.Pro731Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 22 1 21 1 26 9480 35679 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999271810670774 0.99893321465683 0.999524269143814 0.037037037037037 0.000937257091944708 0.189705617413044 0.0454545454545454 0.00115014752657357 0.228444397667633 0.037037037037037 0.000937257091944708 0.189705617413044 0.1792194092827 0.00433692001536546 1.11465955100802 0.0654896005923566 104 4975 False False 0.144754138266796 0.00353417643782867 0.881399653446109 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999271810670774 0.99893321465683 0.999524269143814 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 6.12080991862283 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 3 3) Uncertain significance No change no 1 +Ethambutol embB p.Pro766Arg embB_p.Pro766Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Pro766Leu embB_p.Pro766Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Pro76Leu embB_p.Pro76Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Pro776_Leu777dup embB_p.Pro776_Leu777dup 1 inframe_insertion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Pro776Leu embB_p.Pro776Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.841886116991581 0 0 0.521823750104981 0 0 20.0577749283512 1 2818.5 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.841886116991581 0 0 0.521823750104981 0 0 21.5157135377061 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Pro809Ser embB_p.Pro809Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.10982832991351 0.590980565810755 492 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12104088004766 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Pro818Leu embB_p.Pro818Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Pro818Thr embB_p.Pro818Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Pro824Leu embB_p.Pro824Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Pro832Ser embB_p.Pro832Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 20.058335224773 1 1480 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 21.5165239024995 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 6 3) Uncertain significance No change no 1 +Ethambutol embB p.Pro866Ser embB_p.Pro866Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Pro894Ser embB_p.Pro894Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3715 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3065 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Pro907Ser embB_p.Pro907Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Pro912Thr embB_p.Pro912Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3527 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2910 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Pro92Ser embB_p.Pro92Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3648 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3008 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Pro93His embB_p.Pro93His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Pro93Leu embB_p.Pro93Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 0 0 0.841886116991581 0 0 0.4592581264399 0 0 20.0572146320867 1 2818.5 4975 False False 0 0 3.19822685561766 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 6 6560 26499 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 0 0 0.4592581264399 0 0 0.841886116991581 0 0 0.4592581264399 0 0 21.5149031732103 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 3.43165838346939 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Pro957Leu embB_p.Pro957Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3692 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3045 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Pro999Ser embB_p.Pro999Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Ser1054Pro embB_p.Ser1054Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 42 9479 35663 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.998823694160481 0.99841030518573 0.999152094778215 0.0454545454545454 0.00555295199537049 0.154731577658989 NA NA NA 0 0 0.0840838549403552 NA NA NA NA NA NA False True 0.179157938098754 0.0210070485656453 0.6889482924514 0 0 0.000389087642036349 0.998823694160481 0.99841030518573 0.999152094778215 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 2 31 6558 26474 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.998830409356725 0.99834026667881 0.999205185871022 0.0606060606060606 0.0074258377422598 0.202264312526355 NA NA NA 0 0 0.11218874692237 NA NA NA NA NA NA False True 0 0 0 0 0 1 0 0.260445257700518 0.0301979451574035 1.02402260225925 0 0 0.00056234250533983 0.998830409356725 0.99834026667881 0.999205185871022 4 Not assoc w R Previous WHO guidance 4) Not assoc w R - Interim DOWN from NotAwR to NotAwRI yes Prev. WHO 3 +Ethambutol embB p.Ser10Thr embB_p.Ser10Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3679 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3034 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Ser119Asn embB_p.Ser119Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 146.525883667094 1 2818.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 157.179059039538 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Ser119Ile embB_p.Ser119Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3716 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3066 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ser142Cys embB_p.Ser142Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ser168Leu embB_p.Ser168Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ser174Asn embB_p.Ser174Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Ser203Leu embB_p.Ser203Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 42 0 42 3 57 9478 35648 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.998403584932082 0.997932147274224 0.998790673486123 0.05 0.0104323296443482 0.139243246721072 0 0 0.0840838549403552 0 0 0.0626674809144849 0 0 0.345370786243321 7.92680881615225e-05 22 4975 True False 0.19795426527915 0.0396452167126325 0.608672335498723 0 0 0.000389128685709026 0.998403584932082 0.997932147274224 0.998790673486123 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 31 0 31 3 40 6557 26465 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 0.998490850782871 0.99794552810627 0.998921629563293 0.0697674418604651 0.0146254969951322 0.190607231885792 0 0 0.11218874692237 0 0 0.0880973028788023 0 0 0.510211788287948 0.00228057068736293 32 4087 False False 0 0 0 0 0 0 0 0.302710843373493 0.0598956436193455 0.950979437101673 0 0 0.000562428243381166 0.998490850782871 0.99794552810627 0.998921629563293 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Ser211Phe embB_p.Ser211Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 7 9481 35698 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 3.1981371883326 0.354695326132256 279 4975 False False 0 0 2.61285174975179 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 7 6560 26498 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 3.43152889101174 0.605984763142217 320.5 4087 False False 0 0 0 0 0 0 0 0 0 2.80327602229365 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Ser22Phe embB_p.Ser22Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ser260Glu embB_p.Ser260Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3513 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2897 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Ser261Ala embB_p.Ser261Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ser261Glu embB_p.Ser261Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3677 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3032 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Ser261Pro embB_p.Ser261Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ser272Asn embB_p.Ser272Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Ser297Ala embB_p.Ser297Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 198 62 136 167 176 9314 35529 0.0176141757198607 0.0150625923766859 0.0204679266495614 0.99507071838678 0.994288492190142 0.99577065532227 0.486880466472303 0.432839518604646 0.541149824381802 0.313131313131313 0.249253433183153 0.382706916361639 0.260504201680672 0.205941164068706 0.321139473054295 1.73899979790069 1.26531480013163 2.36720556780449 0.000569658185648842 26 4975 False False 3.61951644152497 2.90745223547548 4.50402903839104 0.00661262798634812 0.00507351238170692 0.00846918035096377 0.99507071838678 0.994288492190142 0.99577065532227 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 169 54 115 157 151 6403 26354 0.0239329268292682 0.020370976913031 0.0279262176092464 0.994302961705338 0.993321654188293 0.995173374917666 0.509740259740259 0.452427240142222 0.566864168826019 0.319526627218934 0.250009086112984 0.395505984892196 0.263414634146341 0.204502228792622 0.329307338072748 1.93267558006097 1.37035306013947 2.69616950436443 0.000132533117956828 21 4087 True False 0 0 0 0 0 0 0 4.27942820676979 3.39422312137198 5.39599851513086 0.00836301688090444 0.00628862152017372 0.0108980000418025 0.994302961705338 0.993321654188293 0.995173374917666 73 3) Uncertain significance No change no 1 +Ethambutol embB p.Ser317Phe embB_p.Ser317Phe 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3547 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2928 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Ser344Arg embB_p.Ser344Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ser347Ile embB_p.Ser347Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 5 3 15 7 9466 35698 0.00158211159160426 0.000885757734327454 0.00260811203671776 0.999803949026747 0.999596102051779 0.999921173824063 0.681818181818181 0.451275572426229 0.861353478446202 0.625 0.244863216366551 0.914766585862746 0.416666666666666 0.15165222980843 0.723330314317894 6.28530178181562 1.22253915348644 40.4856252609687 0.0127955105112484 59 4975 False False 8.08110229090579 3.10037065726486 23.4330653167563 0.000527927357195649 0.000171438086962235 0.00123157267887637 0.999803949026747 0.999596102051779 0.999921173824063 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 4 3 13 6 6547 26499 0.00198170731707317 0.00105558440345171 0.00338639575788259 0.99977362761743 0.99950734823901 0.999916920939814 0.684210526315789 0.434498431153849 0.874239364127016 0.571428571428571 0.184051567640083 0.901011721557492 0.4 0.121552258119827 0.737621923393055 5.39667023063998 0.912682379186309 36.84623849705 0.0323050634802701 55 4087 False False 0 0 0 0 0 0 0 8.76958912478998 3.10825112608178 28.1618082618687 0.000610593802472905 0.000166390521233227 0.00156261801652105 0.99977362761743 0.99950734823901 0.999916920939814 8 3) Uncertain significance No change no 1 +Ethambutol embB p.Ser347Thr embB_p.Ser347Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 13 5 9468 35700 0.00137116337939035 0.000730282374626527 0.00234358976784705 0.999859963590533 0.999673232250017 0.999954529045718 0.722222222222222 0.465198034416943 0.90305078747444 0 0 0.975 0 0 0.521823750104981 0 0 146.72250887435 1 2818.5 4975 False False 9.80354879594423 3.27861739596759 35.1369973325779 0 0 0.000389539599191658 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 10 3 6550 26502 0.00152439024390243 0.000731238785140689 0.00280161526425175 0.999886813808715 0.999669257903365 0.999976657677988 0.769230769230769 0.461868460765959 0.949618926508848 0 0 0.975 0 0 0.707598226178713 0 0 157.418436828106 1 1103 4087 False False 0 0 0 0 0 0 0 13.4870229007633 3.47137630858785 76.2692072697424 0 0 0.000563029142491623 0.999886813808715 0.999669257903365 0.999976657677988 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Ser347Val embB_p.Ser347Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3622 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Ser412Leu embB_p.Ser412Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ser426Arg embB_p.Ser426Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Ser426Asn embB_p.Ser426Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3514 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 2898 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ser480Leu embB_p.Ser480Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ser565Gly embB_p.Ser565Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 7 9481 35698 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 0 0 0.409616397225003 0 0 0.707598226178713 0 0 0.409616397225003 0 0 9.11450885373478 1 2818.5 4975 False False 0 0 2.61285174975179 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 7 6560 26498 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 0 0 0.409616397225003 0 0 0.707598226178713 0 0 0.409616397225003 0 0 9.77836414933522 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 2.80327602229365 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 6 3) Uncertain significance No change no 1 +Ethambutol embB p.Ser565Thr embB_p.Ser565Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 146.54949493291 1 1480 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 157.208880998325 1 2276.5 4087 False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 0 0 0.000562256793434776 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ser617Leu embB_p.Ser617Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ser622Trp embB_p.Ser622Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ser650Cys embB_p.Ser650Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3672 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3029 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Ser650Pro embB_p.Ser650Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ser651Asn embB_p.Ser651Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.096562813829025 Inf 0.209821626167397 198.5 4975 False False Inf 0.096562813829025 Inf 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.103599830448027 Inf 0.198397096627854 142 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 2 3) Uncertain significance No change no 1 +Ethambutol embB p.Ser651Cys embB_p.Ser651Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3557 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2936 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ser651Thr embB_p.Ser651Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3673 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3030 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Ser669Arg embB_p.Ser669Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3613 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ser669Gly embB_p.Ser669Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Ser66Asn embB_p.Ser66Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ser73Leu embB_p.Ser73Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3548 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Ser773Pro embB_p.Ser773Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 24 9478 35681 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999327825234561 0.999000021245735 0.999569278960296 0.111111111111111 0.0235274543808539 0.291586924273551 NA NA NA 0 0 0.142473597722525 NA NA NA NA 3717 4975 False False 0.470576598438489 0.09068613538936279 1.55005463380048 0 0 0.000389128685709026 0.999327825234561 0.999000021245735 0.999569278960296 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3067 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ser823Arg embB_p.Ser823Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Ser856Arg embB_p.Ser856Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 1 3 9480 35702 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99991597815432 0.999754472342108 0.99998267234027 0.25 0.00630946320970987 0.805879550316756 0.333333333333333 0.00840375865961264 0.905700675949754 0.25 0.00630946320970987 0.805879550316756 1.88301687763713 0.0319136788711483 36.177341157522 0.506644351910784 358 4975 False False 1.25534458509142 0.0239099774609589 15.6346568618898 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 1 3 6559 26502 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999886813808715 0.999669257903365 0.999976657677988 0.25 0.00630946320970987 0.805879550316756 0.333333333333333 0.00840375865961264 0.905700675949754 0.25 0.00630946320970987 0.805879550316756 2.02027748132337 0.0342384102171395 38.7744276544107 0.484939389651311 242.5 4087 False False 0 0 0 0 0 0 0 1.34685165421558 0.025651688752077 16.7753654027497 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999886813808715 0.999669257903365 0.999976657677988 2 3) Uncertain significance No change no 1 +Ethambutol embB p.Ser980Ala embB_p.Ser980Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Thr1015Ala embB_p.Thr1015Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3515 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2899 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Thr1025Ile embB_p.Thr1025Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3553 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2932 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Thr1069Pro embB_p.Thr1069Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Thr1082Ala embB_p.Thr1082Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 99 2 97 223 160 9258 35545 0.02352072566185 0.0205645212439261 0.0267744059881402 0.995518834897073 0.994770139290648 0.996185069361846 0.582245430809399 0.531070022099505 0.632139721446118 0.0202020202020202 0.00245599079352773 0.0710761224618775 0.0123456790123456 0.00149863155125946 0.0438834468523532 0.07916251867986 0.00944588951699849 0.293874757716035 6.55100151442015e-08 NA NA False True 5.35113887988766 4.3417958733551 6.60628089370717 0.000215982721382289 2.61575799025329e-05 0.000779983779080637 0.995518834897073 0.994770139290648 0.996185069361846 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 81 1 80 96 108 6464 26397 0.0146341463414634 0.0118693540588704 0.0178418047945668 0.995925297113752 0.995082528193407 0.996656280195635 0.470588235294117 0.400515763418346 0.54152785353678 0.0123456790123456 0.000312516687153829 0.0668756209322107 0.0091743119266055 0.000232246494352311 0.0500568230848124 0.0510461788366336 0.00128058995678557 0.292786668932379 7.50668556987183e-07 NA NA False True 0 1 1 0 0 1 1 3.6299504950495 2.72432307415753 4.83065531953932 0.000154679040989945 3.9161265909338e-06 0.000861511806867894 0.995925297113752 0.995082528193407 0.996656280195635 182 Not assoc w RI 5) Not assoc w R UP from NotAwRI to NotAwR yes 4 +Ethambutol embB p.Thr1084Pro embB_p.Thr1084Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3649 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Thr11Pro embB_p.Thr11Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3641 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3001 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Thr126Asn embB_p.Thr126Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2994 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Thr141Arg embB_p.Thr141Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3614 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2977 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Thr151Ile embB_p.Thr151Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3623 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2986 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Thr151Pro embB_p.Thr151Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3615 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Thr153Asn embB_p.Thr153Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3507 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2892 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Thr157Ala embB_p.Thr157Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3624 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2987 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Thr157Ile embB_p.Thr157Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.10982832991351 0.590980565810755 492 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12104088004766 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Thr208Asn embB_p.Thr208Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3588 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2960 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Thr208Ile embB_p.Thr208Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Thr212Ala embB_p.Thr212Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 2 3 9479 35702 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.99991597815432 0.999754472342108 0.99998267234027 0.4 0.0527449505263169 0.853367200365326 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11745289828119 1 1480 4975 False False 2.51095403875232 0.209684820120099 21.9222407664312 0 0 0.000389087642036349 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 2 3 6558 26502 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999886813808715 0.999669257903365 0.999976657677988 0.4 0.0527449505263169 0.853367200365326 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.78282164268659 1 2276.5 4087 False False 0 0 0 0 0 0 0 2.69411405916437 0.224966079471659 23.5225659748306 0 0 0.00056234250533983 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Thr215Ala embB_p.Thr215Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3658 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Thr215Ile embB_p.Thr215Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Thr216Ala embB_p.Thr216Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Thr275Ala embB_p.Thr275Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Thr275Asn embB_p.Thr275Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Thr279Pro embB_p.Thr279Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 8 9479 35697 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999775941744853 0.999558563909973 0.999903262744512 0.2 0.0252107263268333 0.556095462307641 NA NA NA 0 0 0.369416647552819 NA NA NA NA 3599 4975 False False 0.941475894081654 0.0973783182815292 4.71874266187613 0 0 0.000389087642036349 0.999775941744853 0.999558563909973 0.999903262744512 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 8 6558 26497 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999698170156574 0.999405361976814 0.999869682578628 0.2 0.0252107263268333 0.556095462307641 NA NA NA 0 0 0.369416647552819 NA NA NA NA 2967 4087 False False 0 0 0 0 0 0 0 1.01010216529429 0.104463368269269 5.06308595441747 0 0 0.00056234250533983 0.999698170156574 0.999405361976814 0.999869682578628 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Thr31Ala embB_p.Thr31Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Thr341Asn embB_p.Thr341Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 7 9481 35698 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 3600 4975 False False 0 0 2.61285174975179 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 7 6560 26498 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 2968 4087 False False 0 0 0 0 0 0 0 0 0 2.80327602229365 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Thr341Ile embB_p.Thr341Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Thr498Ala embB_p.Thr498Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3635 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2995 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Thr498Asn embB_p.Thr498Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Thr498Ile embB_p.Thr498Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 2 3) Uncertain significance No change no 1 +Ethambutol embB p.Thr498Pro embB_p.Thr498Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3589 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2961 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Thr498Ser embB_p.Thr498Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3567 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Thr501Ala embB_p.Thr501Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3625 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Thr501Lys embB_p.Thr501Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 157.21479794295 1 1103 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Thr506Asn embB_p.Thr506Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Thr520Ser embB_p.Thr520Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Thr532Ala embB_p.Thr532Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Thr532Ile embB_p.Thr532Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.096562813829025 Inf 0.209821626167397 198.5 4975 False False Inf 0.096562813829025 Inf 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.103599830448027 Inf 0.198397096627854 142 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Thr546Ala embB_p.Thr546Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Thr546Ile embB_p.Thr546Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.096562813829025 Inf 0.209821626167397 198.5 4975 False False Inf 0.096562813829025 Inf 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.103599830448027 Inf 0.198397096627854 142 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Thr581Ala embB_p.Thr581Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3724 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Thr588Met embB_p.Thr588Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Thr642Ala embB_p.Thr642Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 5 1 9476 35704 0.000527370530534753 0.000171257241502832 0.00123027414547083 0.999971992718106 0.999843963402622 0.999999290917266 0.833333333333333 0.358765421002325 0.99578925548551 0 0 0.975 0 0 0.975 0 0 146.615311442367 1 2818.5 4975 False False 18.8391726466863 2.10759583522104 886.708306345849 0 0 0.000389210799037296 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 5 1 6555 26504 0.000762195121951219 0.000247527523788107 0.00177780526826415 0.999962271269571 0.999789807096406 0.999999044791703 0.833333333333333 0.358765421002325 0.99578925548551 0 0 0.975 0 0 0.975 0 0 157.310497938471 1 1103 4087 False False 0 0 0 0 0 0 0 20.2166285278413 2.26137738039683 951.169010205643 0 0 0.00056259979792051 0.999962271269571 0.999789807096406 0.999999044791703 3 3) Uncertain significance No change no 1 +Ethambutol embB p.Thr643Ala embB_p.Thr643Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 9479 35704 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999971992718106 0.999843963402622 0.999999290917266 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 146.569015564619 1 2818.5 4975 False False 7.53328410169849 0.392120325718966 443.147628387906 0 0 0.000389087642036349 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 6558 26504 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999962271269571 0.999789807096406 0.999999044791703 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 157.238712024072 1 1103 4087 False False 0 0 0 0 0 0 0 8.08295211954864 0.420719628662148 475.373667785977 0 0 0.00056234250533983 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Thr643Ile embB_p.Thr643Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 1 5 2 7 9479 35698 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999803949026747 0.999596102051779 0.999921173824063 0.222222222222222 0.0281449734778982 0.600093573716312 0.166666666666666 0.00421074451448947 0.641234578997674 0.125 0.0031597235312519 0.526509670875206 0.753201814537398 0.015926806638187 6.73188308836789 1 2818.5 4975 False False 1.07600259219628 0.109030897238266 5.65147295095111 0.00010548523206751 2.670651284468e-06 0.000587584402906152 0.999803949026747 0.999596102051779 0.999921173824063 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 5 6559 26500 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999811356347858 0.999559824020536 0.9999387451734 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.707598226178713 0 0 0.521823750104981 0 0 9.78059255652978 1 2276.5 4087 False False 0 0 0 0 0 0 0 0.808050007623113 0.0170817619606711 7.22310074751644 0 0 0.000562256793434776 0.999811356347858 0.999559824020536 0.9999387451734 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Thr667Ala embB_p.Thr667Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Thr670Ile embB_p.Thr670Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Thr68Ala embB_p.Thr68Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Thr704Lys embB_p.Thr704Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3590 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2962 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Thr732Ile embB_p.Thr732Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Thr797Ala embB_p.Thr797Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.19822685561766 0.354697857676227 290 4975 False False 0 0 3.19822685561766 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 6560 26499 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.43165838346939 0.605981932438924 311.5 4087 False False 0 0 0 0 0 0 0 0 0 3.43165838346939 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Thr797Met embB_p.Thr797Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12104088004766 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Thr797Pro embB_p.Thr797Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Thr811Ala embB_p.Thr811Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 8 9481 35697 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 0 0 0.369416647552819 0 0 0.409616397225003 0 0 0.369416647552819 0 0 2.61277856511022 0.357639330631355 317 4975 False False 0 0 2.20624116275339 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 7 6560 26498 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 2.80327602229365 0.357905531825047 211.5 4087 False False 0 0 0 0 0 0 0 0 0 2.80327602229365 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Thr819Ile embB_p.Thr819Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Thr822Met embB_p.Thr822Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Thr82Ala embB_p.Thr82Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3558 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2937 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Thr830Met embB_p.Thr830Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Thr849Ala embB_p.Thr849Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.058895521352 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 21.5173342675905 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Thr878Ala embB_p.Thr878Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3650 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3009 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Thr897Pro embB_p.Thr897Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 2 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Thr956Ile embB_p.Thr956Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3729 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Thr981Ala embB_p.Thr981Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3554 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2933 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Thr981Met embB_p.Thr981Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3516 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2900 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Trp1089Arg embB_p.Trp1089Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 1 9479 35704 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999971992718106 0.999843963402622 0.999999290917266 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 3665 4975 False False 7.53328410169849 0.392120325718966 443.147628387906 0 0 0.000389087642036349 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3023 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 4 3) Uncertain significance No change no 1 +Ethambutol embB p.Trp1089Leu embB_p.Trp1089Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3606 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2972 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Trp237Arg embB_p.Trp237Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3542 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2924 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Trp273Leu embB_p.Trp273Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Trp28Ser embB_p.Trp28Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3718 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3068 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Trp332Arg embB_p.Trp332Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 3 3 9 14 9472 35691 0.000949266954962556 0.000434154257137837 0.00180123610483098 0.999607898053494 0.999342206985133 0.999785618166341 0.391304347826087 0.197076423969014 0.61458104261115 0.5 0.118117248757025 0.881882751242974 0.176470588235294 0.0379850680706259 0.434317872844283 3.76805320945946 0.504582749457062 28.1515770097946 0.111232160592901 127 4975 False False 2.42231992036679 0.92453866858021 6.00974126347885 0.000316622691292876 6.52999710463125e-05 0.000925024293243592 0.999607898053494 0.999342206985133 0.999785618166341 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 3 3 9 11 6551 26494 0.00137195121951219 0.000627529309645025 0.00260278604702639 0.999584983965289 0.999257543293353 0.999792807866341 0.45 0.230577896775924 0.684721866959451 0.5 0.118117248757025 0.881882751242974 0.214285714285714 0.0465792878898673 0.507975677048471 4.04426805067928 0.541548246270996 30.2042085460746 0.0967831139792076 96 4087 False False 0 0 0 0 0 0 0 3.30894658691941 1.21136948818155 8.78693616791016 0.00045773573390296 9.4406062075628e-05 0.00133710960874227 0.999584983965289 0.999257543293353 0.999792807866341 5 3) Uncertain significance No change no 1 +Ethambutol embB p.Trp332Leu embB_p.Trp332Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Trp349Arg embB_p.Trp349Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3626 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Trp572Cys embB_p.Trp572Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3693 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3046 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Trp621Ser embB_p.Trp621Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Trp685Leu embB_p.Trp685Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.096562813829025 Inf 0.209821626167397 198.5 4975 False False Inf 0.096562813829025 Inf 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Tyr1018His embB_p.Tyr1018His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Tyr315Cys embB_p.Tyr315Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3706 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3057 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Tyr319Asn embB_p.Tyr319Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Tyr319Asp embB_p.Tyr319Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 10 5 5 9 6 9472 35699 0.000949266954962556 0.000434154257137837 0.00180123610483098 0.99983195630864 0.999634275787128 0.999938328510354 0.6 0.322869766206281 0.836635676140486 0.5 0.187086028447398 0.812913971552601 0.454545454545454 0.167488094063707 0.766206402340654 3.76889780405405 0.867155774279056 16.3870108711239 0.0396613597000067 82 4975 False False 5.65334670608108 1.79648185700579 19.3044842610633 0.000527593120185712 0.000171329533882695 0.00123079323010208 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 4 2 8 3 6552 26502 0.00121951219512195 0.000526641184096925 0.00240150352406598 0.999886813808715 0.999669257903365 0.999976657677988 0.727272727272727 0.390257440427578 0.939782265827093 0.666666666666666 0.222778095503512 0.956728131707258 0.571428571428571 0.184051567640083 0.901011721557492 8.08974358974359 1.15902513149554 89.557517306262 0.0164359917606633 47 4087 False False 0 0 0 0 0 0 0 10.7863247863247 2.58769996828777 63.1925470158722 0.00061012812690665 0.0001662636033188 0.00156142683737791 0.999886813808715 0.999669257903365 0.999976657677988 3 3) Uncertain significance No change no 1 +Ethambutol embB p.Tyr319Cys embB_p.Tyr319Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 38 16 22 34 30 9447 35675 0.00358611960763632 0.00248473185647407 0.00500767053673668 0.999159781543201 0.998800751376515 0.999433038579865 0.53125 0.402309844598351 0.657203471060379 0.421052631578947 0.263098237251484 0.591785545880094 0.347826086956521 0.213543554251505 0.502490050672963 2.74642262574939 1.34765165656681 5.47769354948829 0.00403378847924426 40 4975 False False 4.27984192512614 2.54030572459455 7.24260365082289 0.00169079573074077 0.00096673500407895 0.00274429796248114 0.999159781543201 0.998800751376515 0.999433038579865 3) Uncertain significance 1) Assoc w R WHO 1) Assoc w R 1 27 16 11 27 12 6533 26493 0.00411585365853658 0.00271407267173401 0.00598274243419924 0.999547255234861 0.999209279704825 0.999766038988972 0.692307692307692 0.524308608458315 0.829804097035305 0.592592592592592 0.387983930259681 0.776102708649418 0.571428571428571 0.371793628612095 0.755376063697853 5.89855697646911 2.56926566707256 14.0632604730824 7.60193309058533e-06 18 4087 True False 0 0 0 0 0 0 0 9.12433032297566 4.46637171074095 19.7804714045946 0.00244312108718888 0.0013970795752522 0.00396445147595754 0.999547255234861 0.999209279704825 0.999766038988972 7 Assoc w R 1) Assoc w R No change yes 1 +Ethambutol embB p.Tyr319Phe embB_p.Tyr319Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3570 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Tyr319Ser embB_p.Tyr319Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 218 176 42 204 47 9277 35658 0.0215167176458179 0.0186910146301179 0.0246414392548319 0.998683657751015 0.998249923877253 0.999032645856775 0.812749003984063 0.75889411206361 0.859050366685027 0.807339449541284 0.748636579569688 0.85747767029404 0.789237668161434 0.729775249326185 0.84083729090853 16.1069311199741 11.436847086473 23.141402946997 9.0237939527766e-80 4 4975 True False 16.6832913244606 12.0861915867461 23.4483340042923 0.0186184280122712 0.0159897287939818 0.0215493656567457 0.998683657751015 0.998249923877253 0.999032645856775 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 73 51 22 78 26 6482 26479 0.011890243902439 0.00940977899252809 0.0148176376444599 0.999019053008866 0.998563013375042 0.999359115925842 0.75 0.655529565347755 0.829738569022184 0.698630136986301 0.579988495402232 0.800560390142616 0.662337662337662 0.545540637353491 0.766224038020354 9.46978345628453 5.63616295595036 16.4069685899099 2.51297455965995e-20 8 4087 True False 0 0 0 0 0 0 0 12.2550138846035 7.76505868876132 19.9152795214612 0.00780652074085412 0.00581783192321869 0.0102515071229073 0.999019053008866 0.998563013375042 0.999359115925842 23 Assoc w R 1) Assoc w R No change yes 1 +Ethambutol embB p.Tyr334His embB_p.Tyr334His 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 170 29 9311 35676 0.0179305980381816 0.0153556629288094 0.0208074364850063 0.999187788825094 0.998833735901384 0.999455984066987 0.854271356783919 0.79745993517038 0.900180583379985 0 0 0.841886116991581 0 0 0.119444869069502 0 0 20.4093506669399 1 2818.5 4975 False False 22.4610860717208 15.0700033176886 34.5839538057072 0 0 0.000396106627759827 0.999187788825094 0.998833735901384 0.999455984066987 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 162 25 6398 26480 0.0246951219512195 0.0210758516818631 0.0287448729530928 0.999056781739294 0.998607936501749 0.999389508781733 0.866310160427807 0.80900219323406 0.911578769793466 0 0 0.841886116991581 0 0 0.137185171530712 0 0 22.0429699598643 1 2276.5 4087 False False 0 0 0 0 0 0 0 26.8193810565801 17.510939211353 42.6795312245002 0 0 0.000576401408923851 0.999056781739294 0.998607936501749 0.999389508781733 22 3) Uncertain significance No change no 1 +Ethambutol embB p.Tyr384Ser embB_p.Tyr384Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Tyr519His embB_p.Tyr519His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Tyr730His embB_p.Tyr730His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Tyr813Asp embB_p.Tyr813Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Tyr848His embB_p.Tyr848His 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Tyr977His embB_p.Tyr977His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Val1048Ile embB_p.Val1048Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3719 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3069 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Val1071Phe embB_p.Val1071Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Val116Ile embB_p.Val116Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Val118Ala embB_p.Val118Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Val123Ala embB_p.Val123Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Val130Leu embB_p.Val130Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3720 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3070 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Val130Met embB_p.Val130Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Val131Met embB_p.Val131Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 0 9 0 31 9481 35674 0 0 0.00038900558066021 0.999131774261308 0.998767847272761 0.999410008882762 0 0 0.11218874692237 0 0 0.336267116879942 0 0 0.11218874692237 0 0 1.90668739856718 0.219229894598389 258 4975 False False 0 0 0.475582320728321 0 0 0.00038900558066021 0.999131774261308 0.998767847272761 0.999410008882762 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 0 28 6560 26477 0 0 0.000562171107654053 0.998943595548009 0.998473560567847 0.999297915712891 0 0 0.123436118500263 0 0 0.369416647552819 0 0 0.123436118500263 0 0 2.36516744549819 0.370046335798954 233 4087 False False 0 0 0 0 0 0 0 0 0 0.568567211145857 0 0 0.000562171107654053 0.998943595548009 0.998473560567847 0.999297915712891 2 3) Uncertain significance No change no 1 +Ethambutol embB p.Val135Met embB_p.Val135Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Val162Gly embB_p.Val162Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Val186Ala embB_p.Val186Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3578 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Val186Leu embB_p.Val186Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12104088004766 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Val188Ala embB_p.Val188Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3595 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2965 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Val230Ala embB_p.Val230Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Val231Ile embB_p.Val231Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Val282Ala embB_p.Val282Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 2 3) Uncertain significance No change no 1 +Ethambutol embB p.Val282Leu embB_p.Val282Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3627 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2988 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Val283Met embB_p.Val283Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 11 0 11 0 12 9481 35693 0 0 0.00038900558066021 0.99966391261728 0.999412996653316 0.999826327071809 0 0 0.264648469397051 0 0 0.284914152918154 0 0 0.264648469397051 0 0 1.50030489649552 0.135454869906327 152.5 4975 False False 0 0 1.35519147325258 0 0 0.00038900558066021 0.99966391261728 0.999412996653316 0.999826327071809 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 0 9 6560 26496 0 0 0.000562171107654053 0.999660441426146 0.999355510362951 0.999844720818052 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.336267116879942 0 0 2.04691100627475 0.2201316772645 166 4087 False False 0 0 0 0 0 0 0 0 0 2.04691100627475 0 0 0.000562171107654053 0.999660441426146 0.999355510362951 0.999844720818052 3 3) Uncertain significance No change no 1 +Ethambutol embB p.Val292Ile embB_p.Val292Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 3.76624472573839 0.0479745002090283 294.932792118969 0.375621806809355 335.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 4.04085988717792 0.0514701624188962 316.380494544091 0.35743759524028 195 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Val292Leu embB_p.Val292Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Val292Phe embB_p.Val292Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 9480 35702 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99991597815432 0.999754472342108 0.99998267234027 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11649128277037 1 2818.5 4975 False False 1.25534458509142 0.0239099774609589 15.6346568618898 0 0 0.00038904660702099 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 3 6559 26502 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999886813808715 0.999669257903365 0.999976657677988 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.78133043653875 1 2276.5 4087 False False 0 0 0 0 0 0 0 1.34685165421558 0.025651688752077 16.7753654027497 0 0 0.000562256793434776 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Val29Leu embB_p.Val29Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3680 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3035 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Val309Leu embB_p.Val309Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3725 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3073 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Val309Phe embB_p.Val309Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Val360Leu embB_p.Val360Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Val369Met embB_p.Val369Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3517 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2901 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Val377Ala embB_p.Val377Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Val377Met embB_p.Val377Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Val390Ile embB_p.Val390Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Val39Gly embB_p.Val39Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Val39Leu embB_p.Val39Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Val414Gly embB_p.Val414Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Val414Ile embB_p.Val414Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Val417Ala embB_p.Val417Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.058895521352 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 21.5173342675905 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Val436Gly embB_p.Val436Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Val436Ile embB_p.Val436Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Val444Met embB_p.Val444Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 146.54949493291 1 1480 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2973 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Val452Leu embB_p.Val452Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3726 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3074 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Val456Ala embB_p.Val456Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 89 12 9392 35693 0.00938719544351861 0.00754527862333571 0.0115392300820024 0.99966391261728 0.999412996653316 0.999826327071809 0.881188118811881 0.801654936736428 0.937076595467188 0 0 0.841886116991581 0 0 0.264648469397051 0 0 20.2433877500318 1 2818.5 4975 False False 28.1860182424758 15.352255225673 56.7043973885921 0 0 0.000392691131982143 0.99966391261728 0.999412996653316 0.999826327071809 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 38 4 6522 26501 0.00579268292682926 0.00410241205405612 0.00794232427340546 0.999849085078287 0.999613643356053 0.999958879281354 0.904761904761904 0.77377512844722 0.973436430359239 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3078 4087 False False 0 0 0 0 0 0 0 38.6015792701625 13.8916619636156 148.799080214038 0 0 0.000565445634070596 0.999849085078287 0.999613643356053 0.999958879281354 149 3) Uncertain significance No change no 1 +Ethambutol embB p.Val479Leu embB_p.Val479Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Val488Ala embB_p.Val488Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.096562813829025 Inf 0.209821626167397 198.5 4975 False False Inf 0.096562813829025 Inf 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.103599830448027 Inf 0.198397096627854 142 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Val488Ile embB_p.Val488Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3628 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2989 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Val492Leu embB_p.Val492Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Val492Met embB_p.Val492Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3528 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2911 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Val493Met embB_p.Val493Met 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 1 9479 35704 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999971992718106 0.999843963402622 0.999999290917266 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 3571 4975 False False 7.53328410169849 0.392120325718966 443.147628387906 0 0 0.000389087642036349 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Val502Leu embB_p.Val502Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Val508Phe embB_p.Val508Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Val50Ala embB_p.Val50Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 9478 35705 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 1 0.999896689850119 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3533 4975 False False Inf 1.55639137151076 Inf 0 0 0.000389128685709026 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2916 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 2 3) Uncertain significance No change no 1 +Ethambutol embB p.Val50Met embB_p.Val50Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Val566Leu embB_p.Val566Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Val566Met embB_p.Val566Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 146.529978407112 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 157.179059039538 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Val593Met embB_p.Val593Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 3.76624472573839 0.0479745002090283 294.932792118969 0.375621806809355 335.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 4.04085988717792 0.0514701624188962 316.380494544091 0.35743759524028 195 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Val602Ala embB_p.Val602Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Val602Gly embB_p.Val602Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Val602Ile embB_p.Val602Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Val612Met embB_p.Val612Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Val614Ile embB_p.Val614Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 4 1 9477 35704 0.000421896424427802 0.000114964157806894 0.00107986688593449 0.999971992718106 0.999843963402622 0.999999290917266 0.8 0.28358206388191 0.994949236620532 0 0 0.975 0 0 0.975 0 0 146.59987623386 1 2818.5 4975 False False 15.0697478104885 1.49093500364622 739.038051857485 0 0 0.000389169738041761 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 6558 26504 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999962271269571 0.999789807096406 0.999999044791703 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 157.238712024072 1 1103 4087 False False 0 0 0 0 0 0 0 8.08295211954864 0.420719628662148 475.373667785977 0 0 0.00056234250533983 0.999962271269571 0.999789807096406 0.999999044791703 3 3) Uncertain significance No change no 1 +Ethambutol embB p.Val614Leu embB_p.Val614Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Val618Met embB_p.Val618Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 13 1 12 1 15 9480 35690 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.9995798907716 0.999307188228015 0.999764849596654 0.0625 0.00158111172276588 0.302320738434531 0.0769230769230769 0.00194562849734675 0.360297435267877 0.0625 0.00158111172276588 0.302320738434531 0.313730661040787 0.00734186840591297 2.12095098978142 0.325284579664844 264 4975 False False 0.25098452883263 0.0059648899607233 1.63179223830413 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.9995798907716 0.999307188228015 0.999764849596654 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 1 10 1 12 6559 26493 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999547255234861 0.999209279704825 0.999766038988972 0.0769230769230769 0.00194562849734675 0.360297435267877 0.0909090909090909 0.00229897221381426 0.412779916988382 0.0769230769230769 0.00194562849734675 0.360297435267877 0.403918280225644 0.00930941189863749 2.84023909238965 0.70411210321229 335 4087 False False 0 0 0 0 0 0 0 0.336598566854703 0.00787634621975887 2.27570833059465 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999547255234861 0.999209279704825 0.999766038988972 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Val654Met embB_p.Val654Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Val668Ala embB_p.Val668Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 2 4 9479 35701 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999887970872426 0.999713186009257 0.999969475016731 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.11719759047557 1 2818.5 4975 False False 1.88316278088405 0.170308362439121 13.1422755166224 0 0 0.000389087642036349 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 2 4 6558 26501 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999849085078287 0.999613643356053 0.999958879281354 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.78245264650643 1 2276.5 4087 False False 0 0 0 0 0 0 0 2.02050930161634 0.182720640564327 14.1017085588021 0 0 0.00056234250533983 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Val668Ile embB_p.Val668Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 23 9479 35682 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999355832516454 0.999033588308985 0.99959161063274 0.08 0.00983959001879751 0.260305842105214 NA NA NA 0 0 0.148185128915224 NA NA NA NA NA NA False True 0.327332272253998 0.0374025623440819 1.32514908374572 0 0 0.000389087642036349 0.999355832516454 0.999033588308985 0.99959161063274 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 2 23 6558 26482 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.99913223920015 0.998698215498625 0.999449837068455 0.08 0.00983959001879751 0.260305842105214 NA NA NA 0 0 0.148185128915224 NA NA NA NA NA NA False True 0 0 1 0 0 1 1 0.35114098943209 0.0401207686296057 1.42162966511602 0 0 0.00056234250533983 0.99913223920015 0.998698215498625 0.999449837068455 2 Not assoc w RI Literature evidence (PMID 32143680) 4) Not assoc w R - Interim No change yes Lit. (PMID 32143680) 1 +Ethambutol embB p.Val67Leu embB_p.Val67Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance No change no 1 +Ethambutol embB p.Val710Leu embB_p.Val710Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Val727Met embB_p.Val727Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Val744Ala embB_p.Val744Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3694 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3047 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 4 3) Uncertain significance No change no 1 +Ethambutol embB p.Val755Ile embB_p.Val755Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3678 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3033 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Val77Ile embB_p.Val77Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 2 4 5 5 9476 35700 0.000527370530534753 0.000171257241502832 0.00123027414547083 0.999859963590533 0.999673232250017 0.999954529045718 0.5 0.187086028447398 0.812913971552601 0.333333333333333 0.0432718682927417 0.777221904496487 0.285714285714285 0.0366925661760855 0.709579136262657 1.88370620514985 0.170357515958531 13.1460685785649 0.612133598058379 527 4975 False False 3.7674124102997 0.866815029288652 16.380547623516 0.000211014982063726 2.55559149517483e-05 0.000762048603103055 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 2 2 5 3 6555 26502 0.000762195121951219 0.000247527523788107 0.00177780526826415 0.999886813808715 0.999669257903365 0.999976657677988 0.625 0.244863216366551 0.914766585862746 0.5 0.067585986488543 0.932414013511457 0.4 0.0527449505263169 0.853367200365326 4.04302059496567 0.292989296666128 55.7361046878683 0.178231440174616 119 4087 False False 0 0 0 0 0 0 0 6.73836765827612 1.31049304610532 43.4121450586851 0.000305017538508464 3.69411737253182e-05 0.00110138933757649 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Val783Ile embB_p.Val783Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Val786Ala embB_p.Val786Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3568 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Val793Ile embB_p.Val793Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Val803Ala embB_p.Val803Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3636 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2996 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Val803Met embB_p.Val803Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Val859Ile embB_p.Val859Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3629 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2990 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Val888Met embB_p.Val888Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Val898Met embB_p.Val898Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Val917Ala embB_p.Val917Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3579 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2952 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embB p.Val944Ala embB_p.Val944Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embB p.Val963Met embB_p.Val963Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1001G>A embC_c.-1001G>A 1 upstream_gene_variant 4238862 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3927 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3245 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1002C>T embC_c.-1002C>T 1 upstream_gene_variant 4238861 0 0 0 0 1 3 9480 35702 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99991597815432 0.999754472342108 0.99998267234027 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4036 4975 False False 1.25534458509142 0.0239099774609589 15.6346568618898 0 0 0.00038904660702099 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 3 6559 26502 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999886813808715 0.999669257903365 0.999976657677988 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3337 4087 False False 0 0 0 0 0 0 0 1.34685165421558 0.025651688752077 16.7753654027497 0 0 0.000562256793434776 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1004G>A embC_c.-1004G>A 1 upstream_gene_variant 4238859 1 1 0 1 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 146.525883667094 1 2818.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3130 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 3 3) Uncertain significance No change no 1 +Ethambutol embC c.-100C>T embC_c.-100C>T 1 upstream_gene_variant 4239763 1 201 0 201 102 305 9379 35400 0.0107583588229089 0.00878043305000468 0.0130448567061455 0.991457779022545 0.990448142171546 0.992386204237939 0.25061425061425 0.209229352558937 0.295667928872076 0 0 0.0181852500543862 0 0 0.0120218399931313 0 0 0.0699145017541663 4.88693585008199e-21 NA NA False True 1.26225488054058 0.997457975606912 1.58637751641081 0 0 0.000393235324417808 0.991457779022545 0.990448142171546 0.992386204237939 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 177 0 177 93 255 6467 26250 0.0141768292682926 0.0114573694314695 0.0173397997802664 0.990379173740803 0.989129819279444 0.991519176393954 0.267241379310344 0.221466063395632 0.317027463510604 0 0 0.0206254514795767 0 0 0.0143620612932698 0 0 0.0855161949438658 3.03864135570294e-17 NA NA False True 0 1 1 0 0 1 0 1.48036638499531 1.15278506314984 1.88740219003851 0 0 0.000570253217323602 0.990379173740803 0.989129819279444 0.991519176393954 23 Not assoc w R 5) Not assoc w R No change yes 1 +Ethambutol embC c.-1016C>T embC_c.-1016C>T 1 upstream_gene_variant 4238847 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1017G>A embC_c.-1017G>A 1 upstream_gene_variant 4238846 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1018C>G embC_c.-1018C>G 1 upstream_gene_variant 4238845 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1019C>T embC_c.-1019C>T 1 upstream_gene_variant 4238844 1 5 0 5 2 5 9479 35700 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999859963590533 0.999673232250017 0.999954529045718 0.285714285714285 0.0366925661760855 0.709579136262657 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.1106955919623 0.590976331736624 466 4975 False False 1.50648802616309 0.143410178089837 9.20379905242336 0 0 0.000389087642036349 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 2 3 6558 26502 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999886813808715 0.999669257903365 0.999976657677988 0.4 0.0527449505263169 0.853367200365326 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.78282164268659 1 2276.5 4087 False False 0 0 0 0 0 0 0 2.69411405916437 0.224966079471659 23.5225659748306 0 0 0.00056234250533983 0.999886813808715 0.999669257903365 0.999976657677988 1 3) Uncertain significance No change no 1 +Ethambutol embC c.-1021A>G embC_c.-1021A>G 1 upstream_gene_variant 4238842 0 0 0 0 7 20 9474 35685 0.000738318742748655 0.00029689231210758 0.00152062336565454 0.999439854362134 0.999135032404509 0.999657815983264 0.259259259259259 0.111144562845442 0.462848742276171 NA NA NA 0 0 0.168433470983085 NA NA NA NA 3824 4975 False False 1.31831855604813 0.470836957834012 3.24681590610856 0 0 0.000389292947027732 0.999439854362134 0.999135032404509 0.999657815983264 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethambutol embC c.-1022G>A embC_c.-1022G>A 1 upstream_gene_variant 4238841 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1023A>C embC_c.-1023A>C 1 upstream_gene_variant 4238840 1 5 0 5 5 7 9476 35698 0.000527370530534753 0.000171257241502832 0.00123027414547083 0.999803949026747 0.999596102051779 0.999921173824063 0.416666666666666 0.15165222980843 0.723330314317894 0 0 0.521823750104981 0 0 0.409616397225003 0 0 4.11176681475614 0.590971122708225 461 4975 False False 2.69085810770065 0.673231772336521 9.85136413343077 0 0 0.000389210799037296 0.999803949026747 0.999596102051779 0.999921173824063 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 5 4 6555 26501 0.000762195121951219 0.000247527523788107 0.00177780526826415 0.999849085078287 0.999613643356053 0.999958879281354 0.555555555555555 0.212008506778868 0.863004337734833 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.78692882457465 1 2276.5 4087 False False 0 0 0 0 0 0 0 5.05358504958047 1.08735642260634 25.4630909640805 0 0 0.00056259979792051 0.999849085078287 0.999613643356053 0.999958879281354 6 3) Uncertain significance No change no 1 +Ethambutol embC c.-1025G>A embC_c.-1025G>A 1 upstream_gene_variant 4238838 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1028G>A embC_c.-1028G>A 1 upstream_gene_variant 4238835 1 20 1 19 13 22 9468 35683 0.00137116337939035 0.000730282374626527 0.00234358976784705 0.999383839798347 0.999067273782758 0.999613816670924 0.371428571428571 0.214732118114389 0.550768835812677 0.05 0.0012650894979498 0.248732762772027 0.0434782608695652 0.0011001686304415 0.21948660745348 0.198357903631067 0.00477705521935415 1.24813558795528 0.0985058021438764 125 4975 False False 2.22701828167607 1.03014122478138 4.6222103924015 0.000105607772732073 2.67375373719325e-06 0.000588266826415733 0.999383839798347 0.999067273782758 0.999613816670924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 17 1 16 7 18 6553 26487 0.0010670731707317 0.000429122972600259 0.00219733487653492 0.999320882852292 0.998926913664084 0.999597464048431 0.28 0.120716688504066 0.493876821806255 0.0588235294117647 0.00148817439126663 0.28688939666722 0.0526315789473684 0.00133162880417942 0.260280654195214 0.252622844498702 0.0060267387339069 1.62672718180579 0.223654814248 172 4087 False False 0 0 0 0 0 0 0 1.57187547688081 0.554671579398637 3.94568274732853 0.000152578577967653 3.86294767829945e-06 0.000849816992931799 0.999320882852292 0.998926913664084 0.999597464048431 15 3) Uncertain significance No change no 1 +Ethambutol embC c.-102C>T embC_c.-102C>T 1 upstream_gene_variant 4239761 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.102G>A embC_c.102G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.1035C>G embC_c.1035C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 44 519 9437 35186 0.00464086066870583 0.00337402100022673 0.00622518524648844 0.985464220697381 0.984168520171059 0.986680048648847 0.0781527531083481 0.0573576715227955 0.103498071293564 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.31609764623036 0.226709307523422 0.4308721422159 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 35 448 6525 26057 0.00533536585365853 0.00371900816518109 0.00741246293388664 0.983097528768156 0.981472729952503 0.984615136016843 0.072463768115942 0.0509896797319192 0.0993410524887756 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 1 0.311985153256705 0.214338471106819 0.441025765372866 NA NA NA NA NA NA 45 5) Not assoc w R Now listed Silent mutation no 0 +Ethambutol embC c.-1035C>T embC_c.-1035C>T 1 upstream_gene_variant 4238828 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 1 3) Uncertain significance No change no 1 +Ethambutol embC c.-1036T>C embC_c.-1036T>C 1 upstream_gene_variant 4238827 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3825 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3160 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1043T>C embC_c.-1043T>C 1 upstream_gene_variant 4238820 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.1044C>A embC_c.1044C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.1044C>T embC_c.1044C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.1045C>T embC_c.1045C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-104T>C embC_c.-104T>C 1 upstream_gene_variant 4239759 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1053G>A embC_c.-1053G>A 1 upstream_gene_variant 4238810 1 23 0 23 0 27 9481 35678 0 0 0.00038900558066021 0.999243803388881 0.998899962900125 0.999501604380895 0 0 0.127702867615432 0 0 0.148185128915224 0 0 0.127702867615432 0 0 0.654805637504001 0.00814940854880768 53 4975 False False 0 0 0.551051070388324 0 0 0.00038900558066021 0.999243803388881 0.998899962900125 0.999501604380895 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 21 0 21 0 24 6560 26481 0 0 0.000562171107654053 0.999094510469722 0.998653000996664 0.999419752318005 0 0 0.142473597722525 0 0 0.161097615219079 0 0 0.142473597722525 0 0 0.775457235136135 0.0134208344544698 42 4087 False False 0 0 0 0 0 0 0 0 0 0.67091714745426 0 0 0.000562171107654053 0.999094510469722 0.998653000996664 0.999419752318005 4 3) Uncertain significance No change no 1 +Ethambutol embC c.-1053G>T embC_c.-1053G>T 1 upstream_gene_variant 4238810 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1054C>T embC_c.-1054C>T 1 upstream_gene_variant 4238809 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.1056G>A embC_c.1056G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1058G>A embC_c.-1058G>A 1 upstream_gene_variant 4238805 1 3 0 3 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.11527461591697 1 2818.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 1 3) Uncertain significance No change no 1 +Ethambutol embC c.-1058G>T embC_c.-1058G>T 1 upstream_gene_variant 4238805 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.1059C>T embC_c.1059C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.105G>A embC_c.105G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1061G>T embC_c.-1061G>T 1 upstream_gene_variant 4238802 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1072C>T embC_c.-1072C>T 1 upstream_gene_variant 4238791 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.1077C>T embC_c.1077C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1077G>A embC_c.-1077G>A 1 upstream_gene_variant 4238786 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1085G>A embC_c.-1085G>A 1 upstream_gene_variant 4238778 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.1086G>A embC_c.1086G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.76624472573839 0.0479745002090283 294.932792118969 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1086G>A embC_c.-1086G>A 1 upstream_gene_variant 4238777 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1092G>A embC_c.-1092G>A 1 upstream_gene_variant 4238771 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1093C>T embC_c.-1093C>T 1 upstream_gene_variant 4238770 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1094G>A embC_c.-1094G>A 1 upstream_gene_variant 4238769 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1096G>C embC_c.-1096G>C 1 upstream_gene_variant 4238767 0 0 0 0 6 3 9475 35702 0.000632844636641704 0.000232277107744303 0.00137692358870305 0.99991597815432 0.999754472342108 0.99998267234027 0.666666666666666 0.29929505620854 0.925145368580308 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3877 4975 False False 7.53604221635883 1.60899726455665 46.5481525523134 0 0 0.000389251868698371 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 6 2 6554 26503 0.000914634146341463 0.000335726224038477 0.00198970246660848 0.999924542539143 0.999727448570663 0.999990861620785 0.75 0.349144205587175 0.968145973750055 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3208 4087 False False 0 0 0 0 0 0 0 12.1313701556301 2.1683237669748 123.038341532173 0 0 0.000562685614442453 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1098C>T embC_c.-1098C>T 1 upstream_gene_variant 4238765 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance No change no 1 +Ethambutol embC c.-1099A>G embC_c.-1099A>G 1 upstream_gene_variant 4238764 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3978 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3291 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-10A>C embC_c.-10A>C 1 upstream_gene_variant 4239853 0 0 0 0 23 7 9458 35698 0.00242590444045986 0.00153841761553811 0.00363783762977583 0.999803949026747 0.999596102051779 0.999921173824063 0.766666666666666 0.57716347702178 0.90066213504198 NA NA NA 0 0 0.409616397225003 NA NA NA NA 3964 4975 False False 12.401504395372 5.14939926290337 34.2115002911529 0 0 0.000389951381427405 0.999803949026747 0.999596102051779 0.999921173824063 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 23 7 6537 26498 0.00350609756097561 0.0022238236869373 0.00525625089693 0.999735898887002 0.999455926960675 0.999893811273379 0.766666666666666 0.57716347702178 0.90066213504198 NA NA NA 0 0 0.409616397225003 NA NA NA NA 3278 4087 False False 0 0 0 0 0 0 0 13.3187788194672 5.52960292640418 36.7611943633477 0 0 0.000564148511293225 0.999735898887002 0.999455926960675 0.999893811273379 1 3) Uncertain significance No change no 1 +Ethambutol embC c.1101G>A embC_c.1101G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.1104G>A embC_c.1104G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.1104G>T embC_c.1104G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 2 9478 35703 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999943985436213 0.999797670939776 0.99999321630447 0.6 0.146632799634673 0.947255049473683 NA NA NA NA NA NA NA NA NA NA NA NA False False 5.65040092846592 0.647137685918782 67.7491623796885 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 6557 26505 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 1 0.999860832946126 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.66990152933523 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.1107C>T embC_c.1107C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 6 9480 35699 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99983195630864 0.999634275787128 0.999938328510354 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.627619549929676 0.0136468000350686 5.17448319653473 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-110C>T embC_c.-110C>T 1 upstream_gene_variant 4239753 1 10 0 10 0 10 9481 35695 0 0 0.00038900558066021 0.999719927181067 0.999484996631079 0.999865686288203 0 0 0.30849710781876 0 0 0.30849710781876 0 0 0.30849710781876 0 0 1.67996531074212 0.134582133412278 140.5 4975 False False 0 0 1.67996531074212 0 0 0.00038900558066021 0.999719927181067 0.999484996631079 0.999865686288203 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1112C>T embC_c.-1112C>T 1 upstream_gene_variant 4238751 2 4 0 4 54 29 9427 35676 0.00569560172977534 0.00428152227364256 0.00742506940072673 0.999187788825094 0.998833735901384 0.999455984066987 0.650602409638554 0.53807045896568 0.752041624010026 0 0 0.602364635616474 0 0 0.119444869069502 0 0 5.73381969303631 0.586235226239362 459 4975 False False 7.04690489167212 4.4053093286752 11.4847765453425 0 0 0.000391233457146604 0.999187788825094 0.998833735901384 0.999455984066987 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 3 0 3 51 24 6509 26481 0.00777439024390243 0.00579386453192301 0.0102093652271214 0.999094510469722 0.998653000996664 0.999419752318005 0.68 0.562209483151058 0.783073651418666 0 0 0.707598226178713 0 0 0.142473597722525 0 0 9.84864452367796 1 2276.5 4087 False False 0 0 0 0 0 0 0 8.64527961284375 5.21955736851196 14.6968007526784 0 0 0.000566574641669827 0.999094510469722 0.998653000996664 0.999419752318005 1 3) Uncertain significance No change no 1 +Ethambutol embC c.1113C>G embC_c.1113C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.1113C>T embC_c.1113C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1113C>T embC_c.-1113C>T 1 upstream_gene_variant 4238750 1 4 0 4 1 5 9480 35700 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999859963590533 0.999673232250017 0.999954529045718 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.602364635616474 0 0 0.521823750104981 0 0 5.70559538331064 0.585903624207148 445 4975 False False 0.753164556962025 0.0159260191955521 6.73154939272228 0 0 0.00038904660702099 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 6.12080991862283 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1116C>T embC_c.-1116C>T 1 upstream_gene_variant 4238747 0 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3794 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3131 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.1116G>A embC_c.1116G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.1119G>C embC_c.1119G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1120G>T embC_c.-1120G>T 1 upstream_gene_variant 4238743 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1123C>T embC_c.-1123C>T 1 upstream_gene_variant 4238740 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1125C>G embC_c.-1125C>G 1 upstream_gene_variant 4238738 1 3 1 2 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 1.88306962025316 0.0319145727646777 36.1783621216076 0.506635653517051 355 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 2.02035371245616 0.0342397021387091 38.7759303485373 0.484927822237944 240 4087 False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1133T>G embC_c.-1133T>G 1 upstream_gene_variant 4238730 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3783 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3122 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-113G>A embC_c.-113G>A 1 upstream_gene_variant 4239750 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 2 3) Uncertain significance No change no 1 +Ethambutol embC c.-1140C>G embC_c.-1140C>G 1 upstream_gene_variant 4238723 1 0 0 0 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3878 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3209 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.1146G>T embC_c.1146G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1147G>C embC_c.-1147G>C 1 upstream_gene_variant 4238716 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.1149C>T embC_c.1149C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1154G>A embC_c.-1154G>A 1 upstream_gene_variant 4238709 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.1156C>T embC_c.1156C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.76624472573839 0.0479745002090283 294.932792118969 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1158G>A embC_c.-1158G>A 1 upstream_gene_variant 4238705 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3855 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3189 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1158G>C embC_c.-1158G>C 1 upstream_gene_variant 4238705 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4003 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3310 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.115C>T embC_c.115C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1160G>A embC_c.-1160G>A 1 upstream_gene_variant 4238703 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1163G>C embC_c.-1163G>C 1 upstream_gene_variant 4238700 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12104088004766 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 1 3) Uncertain significance No change no 1 +Ethambutol embC c.-1173G>A embC_c.-1173G>A 1 upstream_gene_variant 4238690 0 0 0 0 2 1 9479 35704 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999971992718106 0.999843963402622 0.999999290917266 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 3839 4975 False False 7.53328410169849 0.392120325718966 443.147628387906 0 0 0.000389087642036349 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 1 6558 26504 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999962271269571 0.999789807096406 0.999999044791703 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 3175 4087 False False 0 0 0 0 0 0 0 8.08295211954864 0.420719628662148 475.373667785977 0 0 0.00056234250533983 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1174A>C embC_c.-1174A>C 1 upstream_gene_variant 4238689 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3795 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.1174C>T embC_c.1174C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1178C>T embC_c.-1178C>T 1 upstream_gene_variant 4238685 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.1185C>T embC_c.1185C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1186C>T embC_c.-1186C>T 1 upstream_gene_variant 4238677 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1187G>A embC_c.-1187G>A 1 upstream_gene_variant 4238676 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1188C>T embC_c.-1188C>T 1 upstream_gene_variant 4238675 1 1136 56 1080 1483 1781 7998 33924 0.156418099356607 0.149159870124999 0.163888070043943 0.950119030948046 0.947810060705191 0.952354430797298 0.454350490196078 0.437163208054439 0.471619653222711 0.0492957746478873 0.037449134803834 0.0635401929951006 0.0304844855743059 0.0231080650363248 0.039405692877882 0.219932760968019 0.164844358212663 0.288139657718416 1.90967030846948e-43 NA NA False True 3.53185517041809 3.28041613595596 3.80165418937785 0.00695306679910603 0.00525642203998157 0.00901975383935571 0.950119030948046 0.947810060705191 0.952354430797298 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 1029 56 973 1403 1498 5157 25007 0.213871951219512 0.20400214425389 0.223996747828952 0.943482361818524 0.940634526924996 0.946232477794007 0.483626335746294 0.465293352605531 0.501992383092589 0.0544217687074829 0.0413680163527292 0.0700924777177151 0.036036036036036 0.0273338147517722 0.046542732942589 0.279087027062468 0.208889552192913 0.366205960226826 1.34115985891613e-28 NA NA False True 0 0 1 0 0 0 1 4.5416150497865 4.19408185907731 4.91735664104543 0.0107423748321503 0.00812459331583975 0.0139274612326552 0.943482361818524 0.940634526924996 0.946232477794007 745 Literature evidence (PMID 32143680) 4) Not assoc w R - Interim UP from Uncertain to NotAwRI yes Lit. (PMID 32143680) 4 +Ethambutol embC c.-1191G>A embC_c.-1191G>A 1 upstream_gene_variant 4238672 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3784 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3123 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1193C>T embC_c.-1193C>T 1 upstream_gene_variant 4238670 1 110 1 109 37 130 9444 35575 0.00390254192595717 0.00274919326450094 0.00537516682549457 0.996359053353872 0.995678147569658 0.996957129261907 0.221556886227544 0.161050323533924 0.292216049422889 0.00909090909090909 0.000230135405550292 0.0496111893119848 0.00763358778625954 0.00019324703518952 0.0417968630642326 0.0345591006765132 0.000871373084458701 0.196702632799371 3.59760024744637e-10 NA NA False True 1.07212963867982 0.722588074130564 1.55653068299092 0.000105876124933827 2.68054780852063e-06 0.000589761266553946 0.996359053353872 0.995678147569658 0.996957129261907 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 83 1 82 36 103 6524 26402 0.00548780487804878 0.00384646348156392 0.00758941639905408 0.996113940765893 0.995288972920975 0.996826998436042 0.258992805755395 0.188452718081132 0.340094933050429 0.0120481927710843 0.000304987313046937 0.0653083735513444 0.00961538461538461 0.000243410832162648 0.052410699703228 0.0493524846345949 0.00123862301566902 0.282891884305151 4.92703928718244e-07 NA NA False True 0 1 1 0 0 1 0 1.41445179263421 0.93879740162893 2.08790867547622 0.000153256704980842 3.88011630133921e-06 0.00085359263427687 0.996113940765893 0.995288972920975 0.996826998436042 6 Not assoc w R 5) Not assoc w R No change yes 1 +Ethambutol embC c.-1196G>A embC_c.-1196G>A 1 upstream_gene_variant 4238667 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1198C>T embC_c.-1198C>T 1 upstream_gene_variant 4238665 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3917 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3235 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.1200G>A embC_c.1200G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 3 9480 35702 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99991597815432 0.999754472342108 0.99998267234027 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.25534458509142 0.0239099774609589 15.6346568618898 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 3 6559 26502 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999886813808715 0.999669257903365 0.999976657677988 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.34685165421558 0.025651688752077 16.7753654027497 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1206G>A embC_c.-1206G>A 1 upstream_gene_variant 4238657 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3936 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3253 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1209A>G embC_c.-1209A>G 1 upstream_gene_variant 4238654 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embC c.-1212C>A embC_c.-1212C>A 1 upstream_gene_variant 4238651 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.1215C>A embC_c.1215C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.76624472573839 0.0479745002090283 294.932792118969 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1215G>A embC_c.-1215G>A 1 upstream_gene_variant 4238648 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12104088004766 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1216T>C embC_c.-1216T>C 1 upstream_gene_variant 4238647 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1221G>A embC_c.-1221G>A 1 upstream_gene_variant 4238642 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.1224G>A embC_c.1224G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1226T>C embC_c.-1226T>C 1 upstream_gene_variant 4238637 1 1 0 1 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 146.54949493291 1 1480 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 157.21479794295 1 1103 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.1227C>A embC_c.1227C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1227G>A embC_c.-1227G>A 1 upstream_gene_variant 4238636 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4037 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3338 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1229T>C embC_c.-1229T>C 1 upstream_gene_variant 4238634 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1230G>A embC_c.-1230G>A 1 upstream_gene_variant 4238633 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 4 3) Uncertain significance No change no 1 +Ethambutol embC c.-1232G>A embC_c.-1232G>A 1 upstream_gene_variant 4238631 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4051 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1234C>A embC_c.-1234C>A 1 upstream_gene_variant 4238629 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1234C>T embC_c.-1234C>T 1 upstream_gene_variant 4238629 1 4 0 4 1 6 9480 35699 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99983195630864 0.999634275787128 0.999938328510354 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.602364635616474 0 0 0.4592581264399 0 0 5.70543556794744 0.585901759484847 441.5 4975 False False 0.627619549929676 0.0136468000350686 5.17448319653473 0 0 0.00038904660702099 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 1 5 6559 26500 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999811356347858 0.999559824020536 0.9999387451734 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.602364635616474 0 0 0.521823750104981 0 0 6.1217432561314 1 2276.5 4087 False False 0 0 0 0 0 0 0 0.808050007623113 0.0170817619606711 7.22310074751644 0 0 0.000562256793434776 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1235A>G embC_c.-1235A>G 1 upstream_gene_variant 4238628 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1236C>T embC_c.-1236C>T 1 upstream_gene_variant 4238627 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance No change no 1 +Ethambutol embC c.1239G>A embC_c.1239G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 3 1 9478 35704 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999971992718106 0.999843963402622 0.999999290917266 0.75 0.194120449683243 0.99369053679029 NA NA NA NA NA NA NA NA NA NA NA NA False False 11.3011183794049 0.90722384791697 591.183089908516 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 3 1 6557 26504 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 0.999962271269571 0.999789807096406 0.999999044791703 0.75 0.194120449683243 0.99369053679029 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 12.1262772609425 0.973374031902014 634.171386087929 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.123T>G embC_c.123T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1241A>C embC_c.-1241A>C 1 upstream_gene_variant 4238622 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.1242G>A embC_c.1242G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 7 9481 35698 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.61285174975179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1245C>T embC_c.-1245C>T 1 upstream_gene_variant 4238618 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embC c.1245G>T embC_c.1245G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.1251G>A embC_c.1251G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1254G>A embC_c.-1254G>A 1 upstream_gene_variant 4238609 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3988 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.1257C>T embC_c.1257C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1257G>A embC_c.-1257G>A 1 upstream_gene_variant 4238606 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1266C>T embC_c.-1266C>T 1 upstream_gene_variant 4238597 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.1266G>A embC_c.1266G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1267A>G embC_c.-1267A>G 1 upstream_gene_variant 4238596 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3762 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-126C>T embC_c.-126C>T 1 upstream_gene_variant 4239737 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.126G>C embC_c.126G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1270C>G embC_c.-1270C>G 1 upstream_gene_variant 4238593 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3864 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3196 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1271G>C embC_c.-1271G>C 1 upstream_gene_variant 4238592 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1272G>A embC_c.-1272G>A 1 upstream_gene_variant 4238591 1 3 0 3 2 4 9479 35701 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999887970872426 0.999713186009257 0.999969475016731 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.11719759047557 1 2818.5 4975 False False 1.88316278088405 0.170308362439121 13.1422755166224 0 0 0.000389087642036349 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 2 4 6558 26501 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999849085078287 0.999613643356053 0.999958879281354 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.78245264650643 1 2276.5 4087 False False 0 0 0 0 0 0 0 2.02050930161634 0.182720640564327 14.1017085588021 0 0 0.00056234250533983 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.1278A>G embC_c.1278A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1279T>G embC_c.-1279T>G 1 upstream_gene_variant 4238584 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1280G>A embC_c.-1280G>A 1 upstream_gene_variant 4238583 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3918 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3236 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1281G>A embC_c.-1281G>A 1 upstream_gene_variant 4238582 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3785 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3124 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1283G>C embC_c.-1283G>C 1 upstream_gene_variant 4238580 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3942 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3259 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1285C>A embC_c.-1285C>A 1 upstream_gene_variant 4238578 1 31 0 31 1 34 9480 35671 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999047752415628 0.998669581250379 0.999340453530361 0.0285714285714285 0.000723104376338095 0.149172079656431 0 0 0.11218874692237 0 0 0.102817924259012 0 0 0.475592540793923 0.00129782997281984 32 4975 False False 0.110669520972946 0.00272642807603407 0.65990922391575 0 0 0.00038904660702099 0.999047752415628 0.998669581250379 0.999340453530361 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 24 0 24 1 26 6559 26479 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999019053008866 0.998563013375042 0.999359115925842 0.037037037037037 0.000937257091944708 0.189705617413044 0 0 0.142473597722525 0 0 0.132274604497754 0 0 0.670968785886956 0.00847975302522295 38 4087 False False 0 0 0 0 0 0 0 0.155271089636084 0.00379045134617473 0.945516273492072 0 0 0.000562256793434776 0.999019053008866 0.998563013375042 0.999359115925842 2 3) Uncertain significance No change no 1 +Ethambutol embC c.-1289A>G embC_c.-1289A>G 1 upstream_gene_variant 4238574 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3770 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3110 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1290C>T embC_c.-1290C>T 1 upstream_gene_variant 4238573 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1293C>A embC_c.-1293C>A 1 upstream_gene_variant 4238570 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1294T>C embC_c.-1294T>C 1 upstream_gene_variant 4238569 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.1296T>G embC_c.1296T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.1299C>G embC_c.1299C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1300T>G embC_c.-1300T>G 1 upstream_gene_variant 4238563 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4004 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3311 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1301G>A embC_c.-1301G>A 1 upstream_gene_variant 4238562 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3908 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3227 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.1306C>T embC_c.1306C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1308C>T embC_c.-1308C>T 1 upstream_gene_variant 4238555 1 1 0 1 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 146.54949493291 1 1480 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3147 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.1308G>A embC_c.1308G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1309C>T embC_c.-1309C>T 1 upstream_gene_variant 4238554 0 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3771 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3111 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1311C>T embC_c.-1311C>T 1 upstream_gene_variant 4238552 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3772 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3112 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1313T>C embC_c.-1313T>C 1 upstream_gene_variant 4238550 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1319T>G embC_c.-1319T>G 1 upstream_gene_variant 4238544 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.1320G>T embC_c.1320G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.1323G>A embC_c.1323G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1327T>C embC_c.-1327T>C 1 upstream_gene_variant 4238536 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embC c.-1330G>A embC_c.-1330G>A 1 upstream_gene_variant 4238533 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.1332C>T embC_c.1332C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.1335G>A embC_c.1335G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1339T>C embC_c.-1339T>C 1 upstream_gene_variant 4238524 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-133T>C embC_c.-133T>C 1 upstream_gene_variant 4239730 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1342T>C embC_c.-1342T>C 1 upstream_gene_variant 4238521 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3965 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3279 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1343G>A embC_c.-1343G>A 1 upstream_gene_variant 4238520 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.1344G>A embC_c.1344G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.1344G>C embC_c.1344G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.1344G>T embC_c.1344G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.1353C>A embC_c.1353C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.1353C>T embC_c.1353C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1354C>T embC_c.-1354C>T 1 upstream_gene_variant 4238509 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1355G>A embC_c.-1355G>A 1 upstream_gene_variant 4238508 1 2 0 2 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.058895521352 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3312 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1356G>A embC_c.-1356G>A 1 upstream_gene_variant 4238507 1 5 0 5 3 7 9478 35698 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999803949026747 0.999596102051779 0.999921173824063 0.3 0.0667395111777345 0.652452850059997 0 0 0.521823750104981 0 0 0.409616397225003 0 0 4.11089905204647 0.59097533953884 464 4975 False False 1.61417417779519 0.269289687209695 7.07224620508753 0 0 0.000389128685709026 0.999803949026747 0.999596102051779 0.999921173824063 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 3 7 6557 26498 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 0.999735898887002 0.999455926960675 0.999893811273379 0.3 0.0667395111777345 0.652452850059997 0 0 0.521823750104981 0 0 0.409616397225003 0 0 4.41111657765145 0.590386618899978 298.5 4087 False False 0 0 0 0 0 0 0 1.73193315758513 0.288910719135753 7.58884844433105 0 0 0.000562428243381166 0.999735898887002 0.999455926960675 0.999893811273379 1 3) Uncertain significance No change no 1 +Ethambutol embC c.-1365C>T embC_c.-1365C>T 1 upstream_gene_variant 4238498 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.1365G>C embC_c.1365G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1367G>A embC_c.-1367G>A 1 upstream_gene_variant 4238496 1 9 0 9 0 9 9481 35696 0 0 0.00038900558066021 0.99974793446296 0.999521555266748 0.999884733314884 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.336267116879942 0 0 1.90786321657339 0.219222996504786 244.5 4975 False False 0 0 1.90786321657339 0 0 0.00038900558066021 0.99974793446296 0.999521555266748 0.999884733314884 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 0 9 6560 26496 0 0 0.000562171107654053 0.999660441426146 0.999355510362951 0.999844720818052 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.336267116879942 0 0 2.04691100627475 0.2201316772645 166 4087 False False 0 0 0 0 0 0 0 0 0 2.04691100627475 0 0 0.000562171107654053 0.999660441426146 0.999355510362951 0.999844720818052 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1371G>A embC_c.-1371G>A 1 upstream_gene_variant 4238492 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1371G>C embC_c.-1371G>C 1 upstream_gene_variant 4238492 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1374C>T embC_c.-1374C>T 1 upstream_gene_variant 4238489 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3943 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3260 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1379A>G embC_c.-1379A>G 1 upstream_gene_variant 4238484 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.1386G>A embC_c.1386G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-138G>A embC_c.-138G>A 1 upstream_gene_variant 4239725 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1390A>C embC_c.-1390A>C 1 upstream_gene_variant 4238473 1 4 0 4 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 0 0 0.602364635616474 0 0 0.4592581264399 0 0 5.70483372250837 0.585894740941386 369 4975 False False 0 0 3.19822685561766 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 2 3) Uncertain significance No change no 1 +Ethambutol embC c.-1390A>G embC_c.-1390A>G 1 upstream_gene_variant 4238473 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.1392C>T embC_c.1392C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1394T>C embC_c.-1394T>C 1 upstream_gene_variant 4238469 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.1395G>A embC_c.1395G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.1396C>A embC_c.1396C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1399A>G embC_c.-1399A>G 1 upstream_gene_variant 4238464 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.1404C>A embC_c.1404C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1406G>A embC_c.-1406G>A 1 upstream_gene_variant 4238457 1 2 0 2 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.841886116991581 0 0 0.521823750104981 0 0 20.0577749283512 1 2818.5 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 21.5165239024995 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 2 3) Uncertain significance No change no 1 +Ethambutol embC c.-1406G>T embC_c.-1406G>T 1 upstream_gene_variant 4238457 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.1407G>T embC_c.1407G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1408C>A embC_c.-1408C>A 1 upstream_gene_variant 4238455 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1408C>T embC_c.-1408C>T 1 upstream_gene_variant 4238455 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1409C>A embC_c.-1409C>A 1 upstream_gene_variant 4238454 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1409C>G embC_c.-1409C>G 1 upstream_gene_variant 4238454 1 1 0 1 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 146.525883667094 1 2818.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3161 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1411C>T embC_c.-1411C>T 1 upstream_gene_variant 4238452 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embC c.-1413G>A embC_c.-1413G>A 1 upstream_gene_variant 4238450 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.1414C>T embC_c.1414C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.10982832991351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.40943166615857 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1418A>C embC_c.-1418A>C 1 upstream_gene_variant 4238445 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1419G>A embC_c.-1419G>A 1 upstream_gene_variant 4238444 1 144 2 142 20 174 9461 35531 0.00210948212213901 0.00128898780543425 0.00325605306957067 0.995126732950567 0.994348611327056 0.995822544570542 0.103092783505154 0.0641175750104009 0.154722781784796 0.0138888888888888 0.00168645694061765 0.0492694619952616 0.0113636363636363 0.00137916398056964 0.0404445651982966 0.0528946855214364 0.00634986671407756 0.194697158816681 1.94318134856586e-12 NA NA False True 0.431669272646205 0.257148966892191 0.687900954930207 0.000211349466342597 2.55964257913085e-05 0.000763256208882834 0.995126732950567 0.994348611327056 0.995822544570542 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 117 2 115 15 143 6545 26362 0.00228658536585365 0.0012803316536391 0.00376857487312357 0.994604791548764 0.993647576822403 0.995450964522221 0.0949367088607595 0.0541140956163094 0.151747167295904 0.017094017094017 0.00207691052584223 0.0603859941367289 0.0137931034482758 0.00167479558564403 0.0489357949039407 0.0700488258544524 0.00837076106408695 0.258967672227265 3.82431668796901e-09 NA NA False True 0 1 1 0 0 1 0 0.422497288807449 0.230275023041618 0.721206713938765 0.000305483427524056 3.69976015731486e-05 0.00110307094727248 0.994604791548764 0.993647576822403 0.995450964522221 16 Not assoc w R 5) Not assoc w R No change yes 1 +Ethambutol embC c.1419G>C embC_c.1419G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 15 9481 35690 0 0 0.00038900558066021 0.9995798907716 0.999307188228015 0.999764849596654 0 0 0.218019360910534 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.04976500705909 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 11 6560 26494 0 0 0.000562171107654053 0.999584983965289 0.999257543293353 0.999792807866341 0 0 0.284914152918154 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.60965686204705 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.141C>G embC_c.141C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.707313928675496 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1424G>A embC_c.-1424G>A 1 upstream_gene_variant 4238439 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3944 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3261 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.1425G>A embC_c.1425G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1425G>A embC_c.-1425G>A 1 upstream_gene_variant 4238438 2 7 0 7 2 11 9479 35694 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999691919899173 0.999448826618347 0.999846197812 0.153846153846153 0.0192066719825284 0.454471055676557 0 0 0.409616397225003 0 0 0.284914152918154 0 0 2.61311028333196 0.357637259078463 306 4975 False False 0.684652197680998 0.0737281243774716 3.13779303174923 0 0 0.000389087642036349 0.999691919899173 0.999448826618347 0.999846197812 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 3 0 3 1 3 6559 26502 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999886813808715 0.999669257903365 0.999976657677988 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.78133043653875 1 2276.5 4087 False False 0 0 0 0 0 0 0 1.34685165421558 0.025651688752077 16.7753654027497 0 0 0.000562256793434776 0.999886813808715 0.999669257903365 0.999976657677988 1 3) Uncertain significance No change no 1 +Ethambutol embC c.-1427G>T embC_c.-1427G>T 1 upstream_gene_variant 4238436 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1428G>A embC_c.-1428G>A 1 upstream_gene_variant 4238435 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3730 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3079 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1428G>C embC_c.-1428G>C 1 upstream_gene_variant 4238435 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance No change no 1 +Ethambutol embC c.-1429C>T embC_c.-1429C>T 1 upstream_gene_variant 4238434 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.1434C>T embC_c.1434C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1437C>G embC_c.-1437C>G 1 upstream_gene_variant 4238426 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.1440C>G embC_c.1440C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1440C>T embC_c.-1440C>T 1 upstream_gene_variant 4238423 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-144G>T embC_c.-144G>T 1 upstream_gene_variant 4239719 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3889 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1452C>T embC_c.-1452C>T 1 upstream_gene_variant 4238411 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1456C>A embC_c.-1456C>A 1 upstream_gene_variant 4238407 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1457C>T embC_c.-1457C>T 1 upstream_gene_variant 4238406 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance No change no 1 +Ethambutol embC c.-1459C>T embC_c.-1459C>T 1 upstream_gene_variant 4238404 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3796 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3132 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1460C>T embC_c.-1460C>T 1 upstream_gene_variant 4238403 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 3 3) Uncertain significance No change no 1 +Ethambutol embC c.-1465T>A embC_c.-1465T>A 1 upstream_gene_variant 4238398 0 0 0 0 4 1 9477 35704 0.000421896424427802 0.000114964157806894 0.00107986688593449 0.999971992718106 0.999843963402622 0.999999290917266 0.8 0.28358206388191 0.994949236620532 NA NA NA 0 0 0.975 NA NA NA NA 3744 4975 False False 15.0697478104885 1.49093500364622 739.038051857485 0 0 0.000389169738041761 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 1 6556 26504 0.000609756097560975 0.000166162208307701 0.00156047520083291 0.999962271269571 0.999789807096406 0.999999044791703 0.8 0.28358206388191 0.994949236620532 NA NA NA 0 0 0.975 NA NA NA NA 3089 4087 False False 0 0 0 0 0 0 0 16.1708358755338 1.59970034177407 792.771744020614 0 0 0.000562514007570737 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1467G>A embC_c.-1467G>A 1 upstream_gene_variant 4238396 1 6 0 6 0 8 9481 35697 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 0 0 0.369416647552819 0 0 0.4592581264399 0 0 0.369416647552819 0 0 3.19804752107404 0.354692794889658 274.5 4975 False False 0 0 2.20624116275339 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 7 6560 26498 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 0 0 0.409616397225003 0 0 0.521823750104981 0 0 0.409616397225003 0 0 4.40909889007489 0.590385105661229 256 4087 False False 0 0 0 0 0 0 0 0 0 2.80327602229365 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 1 3) Uncertain significance No change no 1 +Ethambutol embC c.-1468C>T embC_c.-1468C>T 1 upstream_gene_variant 4238395 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3898 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-146C>T embC_c.-146C>T 1 upstream_gene_variant 4239717 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1470A>C embC_c.-1470A>C 1 upstream_gene_variant 4238393 1 5 0 5 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.10982832991351 0.590980565810755 492 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.40943166615857 0.590385352956204 278 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1472C>T embC_c.-1472C>T 1 upstream_gene_variant 4238391 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3996 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1473G>A embC_c.-1473G>A 1 upstream_gene_variant 4238390 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1476A>C embC_c.-1476A>C 1 upstream_gene_variant 4238387 1 6 0 6 0 7 9481 35698 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 3.1981371883326 0.354695326132256 279 4975 False False 0 0 2.61285174975179 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 7 6560 26498 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 3.43152889101174 0.605984763142217 320.5 4087 False False 0 0 0 0 0 0 0 0 0 2.80327602229365 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 3 3) Uncertain significance No change no 1 +Ethambutol embC c.1476C>G embC_c.1476C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 6 9480 35699 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99983195630864 0.999634275787128 0.999938328510354 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.627619549929676 0.0136468000350686 5.17448319653473 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1478G>A embC_c.-1478G>A 1 upstream_gene_variant 4238385 1 16 0 16 0 16 9481 35689 0 0 0.00038900558066021 0.999551883489707 0.999272388596077 0.99974384169233 0 0 0.205907214207822 0 0 0.205907214207822 0 0 0.205907214207822 0 0 0.976295497466411 0.0325285774548425 75 4975 False False 0 0 0.976295497466411 0 0 0.00038900558066021 0.999551883489707 0.999272388596077 0.99974384169233 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 13 0 13 0 13 6560 26492 0 0 0.000562171107654053 0.999509526504433 0.999161421428146 0.999738818498366 0 0 0.24705263800047 0 0 0.24705263800047 0 0 0.24705263800047 0 0 1.32548813951656 0.0853074354316813 84.5 4087 False False 0 0 0 0 0 0 0 0 0 1.32548813951656 0 0 0.000562171107654053 0.999509526504433 0.999161421428146 0.999738818498366 2 3) Uncertain significance No change no 1 +Ethambutol embC c.-1478G>C embC_c.-1478G>C 1 upstream_gene_variant 4238385 1 3 0 3 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.11527461591697 1 2818.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.77947080093164 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.1479C>T embC_c.1479C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.147G>A embC_c.147G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 9 46 9472 35659 0.000949266954962556 0.000434154257137837 0.00180123610483098 0.998711665032908 0.99828191133238 0.999056627266612 0.163636363636363 0.07765881910622 0.288030002307827 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.736566814776733 0.316859474822418 1.52374026960054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 7 37 6553 26468 0.0010670731707317 0.000429122972600259 0.00219733487653492 0.998604036974155 0.998076357089741 0.999016928650496 0.159090909090909 0.0664434612028956 0.300653213771687 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.764147636114674 0.287340351633091 1.73747369154712 NA NA NA NA NA NA 22 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1482C>T embC_c.-1482C>T 1 upstream_gene_variant 4238381 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4052 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3352 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1488G>A embC_c.-1488G>A 1 upstream_gene_variant 4238375 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3928 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3246 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-148G>A embC_c.-148G>A 1 upstream_gene_variant 4239715 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1491C>T embC_c.-1491C>T 1 upstream_gene_variant 4238372 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4047 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3348 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1497G>A embC_c.-1497G>A 1 upstream_gene_variant 4238366 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-149C>T embC_c.-149C>T 1 upstream_gene_variant 4239714 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4005 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3313 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1500C>G embC_c.-1500C>G 1 upstream_gene_variant 4238363 1 0 0 0 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3731 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3080 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 4 3) Uncertain significance No change no 1 +Ethambutol embC c.-1503C>T embC_c.-1503C>T 1 upstream_gene_variant 4238360 1 2 2 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.707313928675496 Inf 0.0440214455254381 88.5 4975 False False Inf 0.707313928675496 Inf 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.150G>C embC_c.150G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1511G>T embC_c.-1511G>T 1 upstream_gene_variant 4238352 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1512C>T embC_c.-1512C>T 1 upstream_gene_variant 4238351 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 1 3) Uncertain significance No change no 1 +Ethambutol embC c.-1514A>G embC_c.-1514A>G 1 upstream_gene_variant 4238349 1 0 0 0 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3997 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3306 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.1515C>A embC_c.1515C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1519G>A embC_c.-1519G>A 1 upstream_gene_variant 4238344 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethambutol embC c.-1520C>A embC_c.-1520C>A 1 upstream_gene_variant 4238343 0 0 0 0 4 76 9477 35629 0.000421896424427802 0.000114964157806894 0.00107986688593449 0.997871446576109 0.997336511761874 0.998322586648195 0.05 0.0137893939764618 0.123098736443152 NA NA NA 0 0 0.0473787538669306 NA NA NA NA NA NA False True 0.197869634516808 0.0525286214818096 0.528002877563022 0 0 0.000389169738041761 0.997871446576109 0.997336511761874 0.998322586648195 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 4 71 6556 26434 0.000609756097560975 0.000166162208307701 0.00156047520083291 0.997321260139596 0.996622317463543 0.997907307267977 0.0533333333333333 0.0147207646591781 0.130960807278474 NA NA NA 0 0 0.0506294079544037 NA NA NA NA NA NA False True 0 0 0 0 0 1 0 0.227156716995076 0.0602000359783241 0.607986963800987 0 0 0.000562514007570737 0.997321260139596 0.996622317463543 0.997907307267977 5 Not assoc w R Previous WHO guidance 4) Not assoc w R - Interim DOWN from NotAwR to NotAwRI yes Prev. WHO 3 +Ethambutol embC c.1521G>A embC_c.1521G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.1521G>C embC_c.1521G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1524C>A embC_c.-1524C>A 1 upstream_gene_variant 4238339 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3899 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3220 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1534C>G embC_c.-1534C>G 1 upstream_gene_variant 4238329 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3989 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3299 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 1 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1534C>T embC_c.-1534C>T 1 upstream_gene_variant 4238329 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1536C>T embC_c.-1536C>T 1 upstream_gene_variant 4238327 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embC c.-153C>T embC_c.-153C>T 1 upstream_gene_variant 4239710 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1545G>A embC_c.-1545G>A 1 upstream_gene_variant 4238318 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3113 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1546A>C embC_c.-1546A>C 1 upstream_gene_variant 4238317 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1551C>T embC_c.-1551C>T 1 upstream_gene_variant 4238312 1 0 0 0 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3745 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3090 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1553G>A embC_c.-1553G>A 1 upstream_gene_variant 4238310 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3966 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3280 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.1554C>T embC_c.1554C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.10982832991351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-155A>C embC_c.-155A>C 1 upstream_gene_variant 4239708 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embC c.-1560C>A embC_c.-1560C>A 1 upstream_gene_variant 4238303 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1560C>T embC_c.-1560C>T 1 upstream_gene_variant 4238303 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.1563G>A embC_c.1563G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1566G>A embC_c.-1566G>A 1 upstream_gene_variant 4238297 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.156C>A embC_c.156C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 8 9481 35697 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.20624116275339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 7 6560 26498 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.80327602229365 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1570A>G embC_c.-1570A>G 1 upstream_gene_variant 4238293 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1572G>A embC_c.-1572G>A 1 upstream_gene_variant 4238291 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3811 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3148 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1572G>C embC_c.-1572G>C 1 upstream_gene_variant 4238291 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3929 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethambutol embC c.-157A>C embC_c.-157A>C 1 upstream_gene_variant 4239706 0 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3773 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-157A>G embC_c.-157A>G 1 upstream_gene_variant 4239706 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3865 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3197 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-157A>T embC_c.-157A>T 1 upstream_gene_variant 4239706 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1583G>C embC_c.-1583G>C 1 upstream_gene_variant 4238280 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4053 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3353 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1586G>A embC_c.-1586G>A 1 upstream_gene_variant 4238277 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.1587C>T embC_c.1587C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.76624472573839 0.0479745002090283 294.932792118969 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1589C>T embC_c.-1589C>T 1 upstream_gene_variant 4238274 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3812 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3149 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embC c.1590G>A embC_c.1590G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1590G>A embC_c.-1590G>A 1 upstream_gene_variant 4238273 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1591C>T embC_c.-1591C>T 1 upstream_gene_variant 4238272 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4059 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1592C>T embC_c.-1592C>T 1 upstream_gene_variant 4238271 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3967 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1597G>C embC_c.-1597G>C 1 upstream_gene_variant 4238266 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethambutol embC c.-1597G>T embC_c.-1597G>T 1 upstream_gene_variant 4238266 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1599G>A embC_c.-1599G>A 1 upstream_gene_variant 4238264 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1608C>T embC_c.-1608C>T 1 upstream_gene_variant 4238255 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3945 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3262 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1610G>A embC_c.-1610G>A 1 upstream_gene_variant 4238253 1 1 0 1 39 10 9442 35695 0.00411349013817107 0.00292667969846249 0.00561902942957354 0.999719927181067 0.999484996631079 0.999865686288203 0.795918367346938 0.656570006953517 0.897550614504752 0 0 0.975 0 0 0.30849710781876 0 0 147.105045209863 1 2818.5 4975 False False 14.743751323872 7.22294661232834 33.1420640641931 0 0 0.000390612046899405 0.999719927181067 0.999484996631079 0.999865686288203 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 39 9 6521 26496 0.00594512195121951 0.00423087805028808 0.00811830430387006 0.999660441426146 0.999355510362951 0.999844720818052 0.8125 0.673706976043286 0.910501618150627 NA NA NA 0 0 0.336267116879942 NA NA NA NA 3319 4087 False False 0 0 0 0 0 0 0 17.6071154730869 8.38318642384403 41.3746624088828 0 0 0.00056553232103809 0.999660441426146 0.999355510362951 0.999844720818052 2 3) Uncertain significance No change no 1 +Ethambutol embC c.1612C>T embC_c.1612C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.1614G>A embC_c.1614G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1615T>G embC_c.-1615T>G 1 upstream_gene_variant 4238248 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1616T>A embC_c.-1616T>A 1 upstream_gene_variant 4238247 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1616T>G embC_c.-1616T>G 1 upstream_gene_variant 4238247 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3774 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3114 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.1617C>A embC_c.1617C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1617G>A embC_c.-1617G>A 1 upstream_gene_variant 4238246 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1618C>A embC_c.-1618C>A 1 upstream_gene_variant 4238245 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1619G>T embC_c.-1619G>T 1 upstream_gene_variant 4238244 1 1 1 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.096562813829025 Inf 0.209821626167397 198.5 4975 False False Inf 0.096562813829025 Inf 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.103599830448027 Inf 0.198397096627854 142 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-161A>G embC_c.-161A>G 1 upstream_gene_variant 4239702 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1621C>G embC_c.-1621C>G 1 upstream_gene_variant 4238242 1 2 0 2 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0615661524565 1 2818.5 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 157.21479794295 1 1103 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embC c.-1621C>T embC_c.-1621C>T 1 upstream_gene_variant 4238242 1 27 0 27 0 27 9481 35678 0 0 0.00038900558066021 0.999243803388881 0.998899962900125 0.999501604380895 0 0 0.127702867615432 0 0 0.127702867615432 0 0 0.127702867615432 0 0 0.551051070388324 0.0032440590753652 38 4975 False False 0 0 0.551051070388324 0 0 0.00038900558066021 0.999243803388881 0.998899962900125 0.999501604380895 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 27 0 27 0 27 6560 26478 0 0 0.000562171107654053 0.998981324278438 0.998518223777074 0.999328582311798 0 0 0.127702867615432 0 0 0.127702867615432 0 0 0.127702867615432 0 0 0.591113301714895 0.0057553394922161 35 4087 False False 0 0 0 0 0 0 0 0 0 0.591113301714895 0 0 0.000562171107654053 0.998981324278438 0.998518223777074 0.999328582311798 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.1623G>T embC_c.1623G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1624T>C embC_c.-1624T>C 1 upstream_gene_variant 4238239 1 5 0 5 2 5 9479 35700 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999859963590533 0.999673232250017 0.999954529045718 0.285714285714285 0.0366925661760855 0.709579136262657 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.1106955919623 0.590976331736624 466 4975 False False 1.50648802616309 0.143410178089837 9.20379905242336 0 0 0.000389087642036349 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.40943166615857 0.590385352956204 278 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1627T>C embC_c.-1627T>C 1 upstream_gene_variant 4238236 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.162G>A embC_c.162G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.1635G>T embC_c.1635G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1636G>A embC_c.-1636G>A 1 upstream_gene_variant 4238227 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-163A>G embC_c.-163A>G 1 upstream_gene_variant 4239700 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3919 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3237 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1640G>A embC_c.-1640G>A 1 upstream_gene_variant 4238223 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1644G>A embC_c.-1644G>A 1 upstream_gene_variant 4238219 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3755 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1644G>T embC_c.-1644G>T 1 upstream_gene_variant 4238219 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4038 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3339 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1646C>A embC_c.-1646C>A 1 upstream_gene_variant 4238217 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3946 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1646C>G embC_c.-1646C>G 1 upstream_gene_variant 4238217 1 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-164A>G embC_c.-164A>G 1 upstream_gene_variant 4239699 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3813 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3150 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1650G>A embC_c.-1650G>A 1 upstream_gene_variant 4238213 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3281 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.1653G>A embC_c.1653G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1657G>A embC_c.-1657G>A 1 upstream_gene_variant 4238206 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.1659T>C embC_c.1659T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1669A>G embC_c.-1669A>G 1 upstream_gene_variant 4238194 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4039 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3340 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1670C>A embC_c.-1670C>A 1 upstream_gene_variant 4238193 1 10 0 10 0 10 9481 35695 0 0 0.00038900558066021 0.999719927181067 0.999484996631079 0.999865686288203 0 0 0.30849710781876 0 0 0.30849710781876 0 0 0.30849710781876 0 0 1.67996531074212 0.134582133412278 140.5 4975 False False 0 0 1.67996531074212 0 0 0.00038900558066021 0.999719927181067 0.999484996631079 0.999865686288203 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 0 10 6560 26495 0 0 0.000562171107654053 0.999622712695717 0.999306265033238 0.999819061720012 0 0 0.30849710781876 0 0 0.30849710781876 0 0 0.30849710781876 0 0 1.80248078294835 0.227543398369854 177 4087 False False 0 0 0 0 0 0 0 0 0 1.80248078294835 0 0 0.000562171107654053 0.999622712695717 0.999306265033238 0.999819061720012 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1670C>T embC_c.-1670C>T 1 upstream_gene_variant 4238193 1 1 0 1 4 1 9477 35704 0.000421896424427802 0.000114964157806894 0.00107986688593449 0.999971992718106 0.999843963402622 0.999999290917266 0.8 0.28358206388191 0.994949236620532 0 0 0.975 0 0 0.975 0 0 146.59987623386 1 2818.5 4975 False False 15.0697478104885 1.49093500364622 739.038051857485 0 0 0.000389169738041761 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 4 1 6556 26504 0.000609756097560975 0.000166162208307701 0.00156047520083291 0.999962271269571 0.999789807096406 0.999999044791703 0.8 0.28358206388191 0.994949236620532 0 0 0.975 0 0 0.975 0 0 157.28656201851 1 2276.5 4087 False False 0 0 0 0 0 0 0 16.1708358755338 1.59970034177407 792.771744020614 0 0 0.000562514007570737 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1673C>A embC_c.-1673C>A 1 upstream_gene_variant 4238190 1 9 0 9 0 9 9481 35696 0 0 0.00038900558066021 0.99974793446296 0.999521555266748 0.999884733314884 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.336267116879942 0 0 1.90786321657339 0.219222996504786 244.5 4975 False False 0 0 1.90786321657339 0 0 0.00038900558066021 0.99974793446296 0.999521555266748 0.999884733314884 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 0 9 6560 26496 0 0 0.000562171107654053 0.999660441426146 0.999355510362951 0.999844720818052 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.336267116879942 0 0 2.04691100627475 0.2201316772645 166 4087 False False 0 0 0 0 0 0 0 0 0 2.04691100627475 0 0 0.000562171107654053 0.999660441426146 0.999355510362951 0.999844720818052 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1676T>C embC_c.-1676T>C 1 upstream_gene_variant 4238187 1 1 0 1 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 146.529978407112 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 157.179059039538 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.1677T>C embC_c.1677T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 25 37 9456 35668 0.00263685265267376 0.00170713654135637 0.00389007034128332 0.998963730569948 0.998571919150772 0.999270269002357 0.403225806451612 0.280511081267012 0.535503389857728 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.54864636209813 1.46971368960196 4.35103613286639 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 23 33 6537 26472 0.00350609756097561 0.0022238236869373 0.00525625089693 0.998754951895868 0.998251929768768 0.99914281600404 0.410714285714285 0.2809715243846 0.550235082598452 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.82242340801312 1.58119208542775 4.95778668650105 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.1680C>T embC_c.1680C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.10982832991351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.40943166615857 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1688A>G embC_c.-1688A>G 1 upstream_gene_variant 4238175 1 6 0 6 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.19822685561766 0.354697857676227 290 4975 False False 0 0 3.19822685561766 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.40943166615857 0.590385352956204 278 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 2 3) Uncertain significance No change no 1 +Ethambutol embC c.-1689C>T embC_c.-1689C>T 1 upstream_gene_variant 4238174 1 1 0 1 13 6 9468 35699 0.00137116337939035 0.000730282374626527 0.00234358976784705 0.99983195630864 0.999634275787128 0.999938328510354 0.684210526315789 0.434498431153849 0.874239364127016 0 0 0.975 0 0 0.4592581264399 0 0 146.718408536792 1 2818.5 4975 False False 8.16939515561188 2.89591077593891 26.2248670085729 0 0 0.000389539599191658 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 13 6 6547 26499 0.00198170731707317 0.00105558440345171 0.00338639575788259 0.99977362761743 0.99950734823901 0.999916920939814 0.684210526315789 0.434498431153849 0.874239364127016 0 0 0.975 0 0 0.4592581264399 0 0 157.472609190216 1 2276.5 4087 False False 0 0 0 0 0 0 0 8.76958912478998 3.10825112608178 28.1618082618687 0 0 0.000563287063923973 0.99977362761743 0.99950734823901 0.999916920939814 2 3) Uncertain significance No change no 1 +Ethambutol embC c.1692G>A embC_c.1692G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.1692G>T embC_c.1692G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.1695C>T embC_c.1695C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1698G>C embC_c.-1698G>C 1 upstream_gene_variant 4238165 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1699G>A embC_c.-1699G>A 1 upstream_gene_variant 4238164 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3968 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1699G>C embC_c.-1699G>C 1 upstream_gene_variant 4238164 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-16C>G embC_c.-16C>G 1 upstream_gene_variant 4239847 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3866 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3198 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.1710C>T embC_c.1710C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 77 9481 35628 0 0 0.00038900558066021 0.997843439294216 0.997305395465678 0.998297712716848 0 0 0.046778068160404 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 0 0.184452687943054 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 0 77 6560 26428 0 0 0.000562171107654053 0.997094887757026 0.996370426369019 0.997706671413718 0 0 0.046778068160404 NA NA NA NA NA NA NA NA NA NA NA NA False True 1 1 1 0 0 0 0 0 0 0.197800932090918 NA NA NA NA NA NA NA 5) Not assoc w R Now listed Silent mutation no 0 +Ethambutol embC c.-1715G>T embC_c.-1715G>T 1 upstream_gene_variant 4238148 1 0 0 0 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3746 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3091 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 4 3) Uncertain significance No change no 1 +Ethambutol embC c.1719C>T embC_c.1719C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1721G>A embC_c.-1721G>A 1 upstream_gene_variant 4238142 1 25 1 24 6 31 9475 35674 0.000632844636641704 0.000232277107744303 0.00137692358870305 0.999131774261308 0.998767847272761 0.999410008882762 0.162162162162162 0.0619257213333963 0.320137075867671 0.04 0.00101219969931084 0.203516913922414 0.03125 0.000790868597952557 0.162170994181511 0.156877748460861 0.00381819756659134 0.96231075842799 0.0450233448518059 91 4975 False False 0.728722444463358 0.248470246008072 1.77357709167578 0.000105529759392148 2.67177861571188e-06 0.000587832373640432 0.999131774261308 0.998767847272761 0.999410008882762 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 22 1 21 4 28 6556 26477 0.000609756097560975 0.000166162208307701 0.00156047520083291 0.998943595548009 0.998473560567847 0.999297915712891 0.125 0.0351306531033114 0.289948420190755 0.0454545454545454 0.00115014752657357 0.228444397667633 0.0344827586206896 0.000872646883579922 0.177644295488722 0.192313838286992 0.00465325506372571 1.19623457695531 0.103443330823831 99 4087 False False 0 0 0 0 0 0 0 0.576941514860978 0.146986615514371 1.64999885738226 0.000152508769254232 3.86118028152325e-06 0.000849428314837321 0.998943595548009 0.998473560567847 0.999297915712891 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1722C>T embC_c.-1722C>T 1 upstream_gene_variant 4238141 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1723T>C embC_c.-1723T>C 1 upstream_gene_variant 4238140 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embC c.-1724G>A embC_c.-1724G>A 1 upstream_gene_variant 4238139 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1725C>T embC_c.-1725C>T 1 upstream_gene_variant 4238138 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1726C>T embC_c.-1726C>T 1 upstream_gene_variant 4238137 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-172G>A embC_c.-172G>A 1 upstream_gene_variant 4239691 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1730A>C embC_c.-1730A>C 1 upstream_gene_variant 4238133 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.1731C>T embC_c.1731C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.1734G>A embC_c.1734G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1736G>A embC_c.-1736G>A 1 upstream_gene_variant 4238127 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3990 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3300 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-173G>A embC_c.-173G>A 1 upstream_gene_variant 4239690 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3747 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3092 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1743G>A embC_c.-1743G>A 1 upstream_gene_variant 4238120 0 0 0 0 154 582 9327 35123 0.0162430123404704 0.0137952605001325 0.0189940998158417 0.983699761938104 0.982332251498418 0.984987753646053 0.209239130434782 0.180386372120658 0.240443294577966 NA NA NA 0 0 0.00631823631857942 NA NA NA NA NA NA False True 0.996431304452911 0.827561349738615 1.19396602932334 0 0 0.000395427261100885 0.983699761938104 0.982332251498418 0.984987753646053 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 99 473 6461 26032 0.0150914634146341 0.0122820711467651 0.0183430880851781 0.982154310507451 0.980487709103553 0.983713973706816 0.173076923076923 0.142954420423684 0.206620891476116 NA NA NA 0 0 0.00776856696823013 NA NA NA NA NA NA False True 0 1 1 0 0 1 1 0.843299510839635 0.670906873731526 1.05126188860995 0 0 0.00057078263113668 0.982154310507451 0.980487709103553 0.983713973706816 279 Not assoc w R 5) Not assoc w R No change yes 1 +Ethambutol embC c.1749G>T embC_c.1749G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-174C>T embC_c.-174C>T 1 upstream_gene_variant 4239689 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1753C>T embC_c.-1753C>T 1 upstream_gene_variant 4238110 1 10 0 10 19 24 9462 35681 0.00200400801603206 0.00120696150945356 0.00312774546302964 0.999327825234561 0.999000021245735 0.999569278960296 0.441860465116279 0.290781177881064 0.601246135391518 0 0 0.30849710781876 0 0 0.142473597722525 0 0 1.68267836713844 0.134702916519299 146 4975 False False 2.98535809906291 1.54534620421202 5.68924967035238 0 0 0.000389786564106482 0.999327825234561 0.999000021245735 0.999569278960296 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 17 16 6543 26489 0.00259146341463414 0.0015103251531184 0.00414595205096253 0.999396340313148 0.99901987910474 0.999654918214049 0.515151515151515 0.335444478388555 0.692036556395267 0 0 0.409616397225003 0 0 0.205907214207822 0 0 2.80960537527656 0.357960913083446 218 4087 False False 0 0 0 0 0 0 0 4.30147676906617 2.0421689538851 9.10342341110626 0 0 0.000563631326978219 0.999396340313148 0.99901987910474 0.999654918214049 9 3) Uncertain significance No change no 1 +Ethambutol embC c.1755G>A embC_c.1755G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1755G>A embC_c.-1755G>A 1 upstream_gene_variant 4238108 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1756C>G embC_c.-1756C>G 1 upstream_gene_variant 4238107 1 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1759T>C embC_c.-1759T>C 1 upstream_gene_variant 4238104 1 15 0 15 3 15 9478 35690 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.9995798907716 0.999307188228015 0.999764849596654 0.166666666666666 0.0357850831215746 0.414177491394774 0 0 0.218019360910534 0 0 0.218019360910534 0 0 1.05009733321424 0.0524877452915845 99 4975 False False 0.75311247098544 0.139746231416637 2.66305750037082 0 0 0.000389128685709026 0.9995798907716 0.999307188228015 0.999764849596654 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 15 0 15 3 15 6557 26490 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 0.999434069043576 0.999066754461952 0.999683219243554 0.166666666666666 0.0357850831215746 0.414177491394774 0 0 0.218019360910534 0 0 0.218019360910534 0 0 1.12671754924397 0.0535166884022173 73 4087 False False 0 0 0 0 0 0 0 0.807991459508921 0.149868367774548 2.85735344409399 0 0 0.000562428243381166 0.999434069043576 0.999066754461952 0.999683219243554 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1759T>G embC_c.-1759T>G 1 upstream_gene_variant 4238104 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3814 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3151 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-176C>G embC_c.-176C>G 1 upstream_gene_variant 4239687 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1770G>A embC_c.-1770G>A 1 upstream_gene_variant 4238093 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3937 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1772G>A embC_c.-1772G>A 1 upstream_gene_variant 4238091 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1776G>A embC_c.-1776G>A 1 upstream_gene_variant 4238087 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.1779C>T embC_c.1779C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1779G>A embC_c.-1779G>A 1 upstream_gene_variant 4238084 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1780C>A embC_c.-1780C>A 1 upstream_gene_variant 4238083 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1785C>G embC_c.-1785C>G 1 upstream_gene_variant 4238078 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4040 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3341 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1786C>T embC_c.-1786C>T 1 upstream_gene_variant 4238077 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.1786T>C embC_c.1786T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1787G>A embC_c.-1787G>A 1 upstream_gene_variant 4238076 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.1788G>A embC_c.1788G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-178G>A embC_c.-178G>A 1 upstream_gene_variant 4239685 1 6 0 6 0 7 9481 35698 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 3.1981371883326 0.354695326132256 279 4975 False False 0 0 2.61285174975179 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 6 6560 26499 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 4.40926527811573 0.590385229079199 260 4087 False False 0 0 0 0 0 0 0 0 0 3.43165838346939 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-178G>C embC_c.-178G>C 1 upstream_gene_variant 4239685 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-178G>T embC_c.-178G>T 1 upstream_gene_variant 4239685 1 7 0 7 0 8 9481 35697 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 0 0 0.369416647552819 0 0 0.409616397225003 0 0 0.369416647552819 0 0 2.61277856511022 0.357639330631355 317 4975 False False 0 0 2.20624116275339 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 7 6560 26498 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 3.43152889101174 0.605984763142217 320.5 4087 False False 0 0 0 0 0 0 0 0 0 2.80327602229365 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.1791C>T embC_c.1791C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1791G>C embC_c.-1791G>C 1 upstream_gene_variant 4238072 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1796T>C embC_c.-1796T>C 1 upstream_gene_variant 4238067 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1797G>A embC_c.-1797G>A 1 upstream_gene_variant 4238066 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 1 3) Uncertain significance No change no 1 +Ethambutol embC c.-1798T>A embC_c.-1798T>A 1 upstream_gene_variant 4238065 0 0 0 0 1 5 9480 35700 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999859963590533 0.999673232250017 0.999954529045718 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA 0 0 0.521823750104981 NA NA NA NA 3920 4975 False False 0.753164556962025 0.0159260191955521 6.73154939272228 0 0 0.00038904660702099 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 5 6559 26500 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999811356347858 0.999559824020536 0.9999387451734 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA 0 0 0.521823750104981 NA NA NA NA 3238 4087 False False 0 0 0 0 0 0 0 0.808050007623113 0.0170817619606711 7.22310074751644 0 0 0.000562256793434776 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-179C>T embC_c.-179C>T 1 upstream_gene_variant 4239684 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.1800G>A embC_c.1800G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1802G>A embC_c.-1802G>A 1 upstream_gene_variant 4238061 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.1803G>A embC_c.1803G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1803G>C embC_c.-1803G>C 1 upstream_gene_variant 4238060 1 69 0 69 0 76 9481 35629 0 0 0.00038900558066021 0.997871446576109 0.997336511761874 0.998322586648195 0 0 0.0473787538669306 0 0 0.0520580578630797 0 0 0.0473787538669306 0 0 0.206450735716699 1.30825791632164e-07 16 4975 True True 0 0 0.186942251712177 0 0 0.00038900558066021 0.997871446576109 0.997336511761874 0.998322586648195 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 51 0 51 0 58 6560 26447 0 0 0.000562171107654053 0.997811733635163 0.997172064607892 0.998337951124302 0 0 0.0616210089039198 0 0 0.0697770307495386 0 0 0.0616210089039198 0 0 0.302508653740946 2.33010216277675e-05 20 4087 True True 1 1 1 0 0 0 0 0 0 0.264833784872545 0 0 0.000562171107654053 0.997811733635163 0.997172064607892 0.998337951124302 4 5) Not assoc w R UP from Uncertain to NotAwR yes 4 +Ethambutol embC c.-1804C>T embC_c.-1804C>T 1 upstream_gene_variant 4238059 1 23 0 23 1 24 9480 35681 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999327825234561 0.999000021245735 0.999569278960296 0.04 0.00101219969931084 0.203516913922414 0 0 0.148185128915224 0 0 0.142473597722525 0 0 0.654929782043397 0.00814889544726852 50 4975 False False 0.156825773558368 0.0038169342444347 0.96199162522442 0 0 0.00038904660702099 0.999327825234561 0.999000021245735 0.999569278960296 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 2 3) Uncertain significance No change no 1 +Ethambutol embC c.-1808G>A embC_c.-1808G>A 1 upstream_gene_variant 4238055 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.1809T>C embC_c.1809T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-180G>A embC_c.-180G>A 1 upstream_gene_variant 4239683 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3909 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.1812C>T embC_c.1812C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.1821G>A embC_c.1821G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1823G>A embC_c.-1823G>A 1 upstream_gene_variant 4238040 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1826G>A embC_c.-1826G>A 1 upstream_gene_variant 4238037 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embC c.-1826G>C embC_c.-1826G>C 1 upstream_gene_variant 4238037 0 0 0 0 35 1 9446 35704 0.00369159371374327 0.00257263665643651 0.00513040870946252 0.999971992718106 0.999843963402622 0.999999290917266 0.972222222222222 0.854710735253146 0.999296974794095 NA NA NA 0 0 0.975 NA NA NA NA 3969 4975 False False 132.293034088503 22.2281044922523 5203.07470728475 0 0 0.000390446670748491 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 30 1 6530 26504 0.00457317073170731 0.00308756239284879 0.00652210018905333 0.999962271269571 0.999789807096406 0.999999044791703 0.967741935483871 0.832978883769772 0.999183629928153 NA NA NA 0 0 0.975 NA NA NA NA 3282 4087 False False 0 0 0 0 0 0 0 121.764165390505 20.2237677012036 4824.20164151689 0 0 0.000564753093874087 0.999962271269571 0.999789807096406 0.999999044791703 16 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.1827G>A embC_c.1827G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1831C>G embC_c.-1831C>G 1 upstream_gene_variant 4238032 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1833A>C embC_c.-1833A>C 1 upstream_gene_variant 4238030 1 0 0 0 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4006 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3314 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 4 3) Uncertain significance No change no 1 +Ethambutol embC c.-183C>A embC_c.-183C>A 1 upstream_gene_variant 4239680 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3732 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3081 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-183C>T embC_c.-183C>T 1 upstream_gene_variant 4239680 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1840A>G embC_c.-1840A>G 1 upstream_gene_variant 4238023 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4028 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3329 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1841C>A embC_c.-1841C>A 1 upstream_gene_variant 4238022 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1844G>C embC_c.-1844G>C 1 upstream_gene_variant 4238019 0 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3867 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3199 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1846T>C embC_c.-1846T>C 1 upstream_gene_variant 4238017 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1848T>G embC_c.-1848T>G 1 upstream_gene_variant 4238015 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.1849C>A embC_c.1849C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1851C>T embC_c.-1851C>T 1 upstream_gene_variant 4238012 0 0 0 0 2 3 9479 35702 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.99991597815432 0.999754472342108 0.99998267234027 0.4 0.0527449505263169 0.853367200365326 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4054 4975 False False 2.51095403875232 0.209684820120099 21.9222407664312 0 0 0.000389087642036349 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3354 4087 False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 0 0 0.000562256793434776 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance No change no 1 +Ethambutol embC c.1857G>A embC_c.1857G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1857G>T embC_c.-1857G>T 1 upstream_gene_variant 4238006 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4007 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3315 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1859G>T embC_c.-1859G>T 1 upstream_gene_variant 4238004 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1861A>C embC_c.-1861A>C 1 upstream_gene_variant 4238002 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1863G>A embC_c.-1863G>A 1 upstream_gene_variant 4238000 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1864G>C embC_c.-1864G>C 1 upstream_gene_variant 4237999 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3947 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1864G>T embC_c.-1864G>T 1 upstream_gene_variant 4237999 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1865C>T embC_c.-1865C>T 1 upstream_gene_variant 4237998 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1867C>G embC_c.-1867C>G 1 upstream_gene_variant 4237996 0 0 0 0 4 0 9477 35705 0.000421896424427802 0.000114964157806894 0.00107986688593449 1 0.999896689850119 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3856 4975 False False Inf 2.4863933079676 Inf 0 0 0.000389169738041761 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1867C>T embC_c.-1867C>T 1 upstream_gene_variant 4237996 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.1869C>T embC_c.1869C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.186C>T embC_c.186C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.1872C>G embC_c.1872C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1874G>A embC_c.-1874G>A 1 upstream_gene_variant 4237989 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1877T>C embC_c.-1877T>C 1 upstream_gene_variant 4237986 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1878G>A embC_c.-1878G>A 1 upstream_gene_variant 4237985 1 2 0 2 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0615661524565 1 2818.5 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 157.21479794295 1 1103 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1880A>G embC_c.-1880A>G 1 upstream_gene_variant 4237983 1 22 0 22 1 29 9480 35676 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999187788825094 0.998833735901384 0.999455984066987 0.0333333333333333 0.000843570926630479 0.172169455633412 0 0 0.154372512815574 0 0 0.119444869069502 0 0 0.687169223941865 0.00800008197208247 49 4975 False False 0.12976865997381 0.00318076245652646 0.78291018102378 0 0 0.00038904660702099 0.999187788825094 0.998833735901384 0.999455984066987 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 14 0 14 1 20 6559 26485 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999245425391435 0.998834860097994 0.999539027227828 0.0476190476190476 0.00120488344836351 0.238159909936821 0 0 0.231635761650116 0 0 0.168433470983085 0 0 1.21770650339572 0.0874891957251696 93 4087 False False 0 0 0 0 0 0 0 0.201898155206586 0.00487402352307712 1.26281197655001 0 0 0.000562256793434776 0.999245425391435 0.998834860097994 0.999539027227828 3 3) Uncertain significance No change no 1 +Ethambutol embC c.-1886G>A embC_c.-1886G>A 1 upstream_gene_variant 4237977 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1886G>T embC_c.-1886G>T 1 upstream_gene_variant 4237977 1 5 0 5 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.10982832991351 0.590980565810755 492 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.40943166615857 0.590385352956204 278 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.1887G>A embC_c.1887G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.1888T>C embC_c.1888T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1889G>A embC_c.-1889G>A 1 upstream_gene_variant 4237974 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1889G>C embC_c.-1889G>C 1 upstream_gene_variant 4237974 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1892A>T embC_c.-1892A>T 1 upstream_gene_variant 4237971 1 11 1 10 4 19 9477 35686 0.000421896424427802 0.000114964157806894 0.00107986688593449 0.999467861644027 0.999169124220115 0.999679588507228 0.17391304347826 0.0495076453057934 0.387811889954797 0.0909090909090909 0.00229897221381426 0.412779916988382 0.05 0.0012650894979498 0.248732762772027 0.376553761738946 0.00867940564033186 2.64757007233806 0.477498897563888 344 4975 False False 0.792744761555677 0.196090469117302 2.38618166160344 0.000105507491031863 2.67121483114821e-06 0.000587708362116832 0.999467861644027 0.999169124220115 0.999679588507228 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 1 9 4 17 6556 26488 0.000609756097560975 0.000166162208307701 0.00156047520083291 0.99935861158272 0.998973272974466 0.999626324627714 0.19047619047619 0.0544635681784068 0.419066041183528 0.1 0.00252857854446178 0.445016117028195 0.0555555555555555 0.00140555616736942 0.272943599673368 0.448918717375093 0.0102439411200292 3.24082890134217 0.697989253266412 333 4087 False False 0 0 0 0 0 0 0 0.950651401500197 0.232644735675483 2.91585455630484 0.000152508769254232 3.86118028152325e-06 0.000849428314837321 0.99935861158272 0.998973272974466 0.999626324627714 4 3) Uncertain significance No change no 1 +Ethambutol embC c.1894C>T embC_c.1894C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.1896G>A embC_c.1896G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.1896G>C embC_c.1896G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 0 NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1897A>C embC_c.-1897A>C 1 upstream_gene_variant 4237966 0 0 0 0 2 1 9479 35704 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999971992718106 0.999843963402622 0.999999290917266 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 3826 4975 False False 7.53328410169849 0.392120325718966 443.147628387906 0 0 0.000389087642036349 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3162 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 4 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.1899G>A embC_c.1899G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1899G>A embC_c.-1899G>A 1 upstream_gene_variant 4237964 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embC c.189A>G embC_c.189A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1900G>A embC_c.-1900G>A 1 upstream_gene_variant 4237963 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1900G>T embC_c.-1900G>T 1 upstream_gene_variant 4237963 0 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3840 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3176 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 4 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1901G>C embC_c.-1901G>C 1 upstream_gene_variant 4237962 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1901G>T embC_c.-1901G>T 1 upstream_gene_variant 4237962 1 14 1 13 7 15 9474 35690 0.000738318742748655 0.00029689231210758 0.00152062336565454 0.9995798907716 0.999307188228015 0.999764849596654 0.318181818181818 0.138646521553797 0.54872442757377 0.0714285714285714 0.00180678065912538 0.338684489931821 0.0625 0.00158111172276588 0.302320738434531 0.289780938925967 0.00682155572475873 1.92978128164167 0.326291694120202 266 4975 False False 1.75800436281753 0.606176620802685 4.58225401964346 0.000105540897097625 2.6720605972471e-06 0.000587894399029927 0.9995798907716 0.999307188228015 0.999764849596654 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 1 8 3 10 6557 26495 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 0.999622712695717 0.999306265033238 0.999819061720012 0.23076923076923 0.0503810734911515 0.53813153923404 0.111111111111111 0.00280913674659921 0.482496514917337 0.0909090909090909 0.00229897221381426 0.412779916988382 0.50508998017386 0.0113846619224231 3.76854865038056 1 2276.5 4087 False False 0 0 0 0 0 0 0 1.21221595241726 0.214314396732616 4.70983259529179 0.000152485513876181 3.86059150860036e-06 0.000849298834468653 0.999622712695717 0.999306265033238 0.999819061720012 1 3) Uncertain significance No change no 1 +Ethambutol embC c.-1903_-1900delTCGGinsC embC_c.-1903_-1900delTCGGinsC 1 upstream_gene_variant 4237960 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3879 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1905A>T embC_c.-1905A>T 1 upstream_gene_variant 4237958 0 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3797 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3133 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 4 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.1908T>C embC_c.1908T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-190T>C embC_c.-190T>C 1 upstream_gene_variant 4239673 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1910C>T embC_c.-1910C>T 1 upstream_gene_variant 4237953 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3910 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3228 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.1911C>A embC_c.1911C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1917C>T embC_c.-1917C>T 1 upstream_gene_variant 4237946 1 12 0 12 3 14 9478 35691 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999607898053494 0.999342206985133 0.999785618166341 0.176470588235294 0.0379850680706259 0.434317872844283 0 0 0.264648469397051 0 0 0.231635761650116 0 0 1.3555445264085 0.0836056980823074 116 4975 False False 0.806928827661049 0.148632172529879 2.89199942983288 0 0 0.000389128685709026 0.999607898053494 0.999342206985133 0.999785618166341 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 2 10 6558 26495 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999622712695717 0.999306265033238 0.999819061720012 0.166666666666666 0.0208625254600923 0.484137748685967 0 0 0.369416647552819 0 0 0.30849710781876 0 0 2.36749714644489 0.369969877532654 220 4087 False False 0 0 0 0 0 0 0 0.808020738029887 0.0860624002038487 3.79288404060304 0 0 0.00056234250533983 0.999622712695717 0.999306265033238 0.999819061720012 10 3) Uncertain significance No change no 1 +Ethambutol embC c.-191G>A embC_c.-191G>A 1 upstream_gene_variant 4239672 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3911 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3229 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1923C>A embC_c.-1923C>A 1 upstream_gene_variant 4237940 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3802 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3139 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1924_-1871delGCAGACGCAAAAGCCCCCAATTCGGGCACGAAATGGGGGCTTTTACGTCTGCTC embC_c.-1924_-1871delGCAGACGCAAAAGCCCCCAATTCGGGCACGAAATGGGGGCTTTTACGTCTGCTC 1 upstream_gene_variant 4237938 1 6 0 6 0 9 9481 35696 0 0 0.00038900558066021 0.99974793446296 0.999521555266748 0.999884733314884 0 0 0.336267116879942 0 0 0.4592581264399 0 0 0.336267116879942 0 0 3.19795785384198 0.354690263948473 272 4975 False False 0 0 1.90786321657339 0 0 0.00038900558066021 0.99974793446296 0.999521555266748 0.999884733314884 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 8 6560 26497 0 0 0.000562171107654053 0.999698170156574 0.999405361976814 0.999869682578628 0 0 0.369416647552819 0 0 0.521823750104981 0 0 0.369416647552819 0 0 4.40893250203607 0.590384982702355 253.5 4087 False False 0 0 0 0 0 0 0 0 0 2.36695385477914 0 0 0.000562171107654053 0.999698170156574 0.999405361976814 0.999869682578628 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1925A>G embC_c.-1925A>G 1 upstream_gene_variant 4237938 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3798 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3134 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1927C>T embC_c.-1927C>T 1 upstream_gene_variant 4237936 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3763 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3105 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.192C>T embC_c.192C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1935G>A embC_c.-1935G>A 1 upstream_gene_variant 4237928 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3815 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3152 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1938T>C embC_c.-1938T>C 1 upstream_gene_variant 4237925 1 8 0 8 3 8 9478 35697 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999775941744853 0.999558563909973 0.999903262744512 0.272727272727272 0.0602177341729066 0.609742559572421 0 0 0.369416647552819 0 0 0.369416647552819 0 0 2.20694000387466 0.217708874145343 236 4975 False False 1.41236284026165 0.241278697490708 5.88592307150449 0 0 0.000389128685709026 0.999775941744853 0.999558563909973 0.999903262744512 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 2 6 6558 26499 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.99977362761743 0.99950734823901 0.999916920939814 0.25 0.0318540262499442 0.650855794412824 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.4327051354578 0.605959064776906 302 4087 False False 0 0 0 0 0 0 0 1.34690454406831 0.132947871900757 7.53464906456895 0 0 0.00056234250533983 0.99977362761743 0.99950734823901 0.999916920939814 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1942C>A embC_c.-1942C>A 1 upstream_gene_variant 4237921 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1942C>T embC_c.-1942C>T 1 upstream_gene_variant 4237921 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3803 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3140 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.1944G>A embC_c.1944G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1948A>G embC_c.-1948A>G 1 upstream_gene_variant 4237915 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1949C>A embC_c.-1949C>A 1 upstream_gene_variant 4237914 1 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 157.21479794295 1 1103 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.1953G>A embC_c.1953G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.1953G>T embC_c.1953G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1964G>A embC_c.-1964G>A 1 upstream_gene_variant 4237899 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3827 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3163 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1966C>T embC_c.-1966C>T 1 upstream_gene_variant 4237897 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4060 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3358 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1970C>T embC_c.-1970C>T 1 upstream_gene_variant 4237893 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1972C>A embC_c.-1972C>A 1 upstream_gene_variant 4237891 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3948 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3263 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1976G>A embC_c.-1976G>A 1 upstream_gene_variant 4237887 1 2 0 2 2 12 9479 35693 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.99966391261728 0.999412996653316 0.999826327071809 0.142857142857142 0.0177945154831915 0.428129160909698 0 0 0.841886116991581 0 0 0.264648469397051 0 0 20.0580727799714 1 2818.5 4975 False False 0.627580265147519 0.0682070896184037 2.81999711742652 0 0 0.000389087642036349 0.99966391261728 0.999412996653316 0.999826327071809 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 12 6559 26493 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999547255234861 0.999209279704825 0.999766038988972 0.0769230769230769 0.00194562849734675 0.360297435267877 0 0 0.841886116991581 0 0 0.264648469397051 0 0 21.5133145827523 1 1103 4087 False False 0 0 0 0 0 0 0 0.336598566854703 0.00787634621975887 2.27570833059465 0 0 0.000562256793434776 0.999547255234861 0.999209279704825 0.999766038988972 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-1976G>T embC_c.-1976G>T 1 upstream_gene_variant 4237887 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-197C>T embC_c.-197C>T 1 upstream_gene_variant 4239666 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3748 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3093 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-1980T>C embC_c.-1980T>C 1 upstream_gene_variant 4237883 1 2 0 2 0 13 9481 35692 0 0 0.00038900558066021 0.999635905335387 0.999377467513205 0.999806121137399 0 0 0.24705263800047 0 0 0.841886116991581 0 0 0.24705263800047 0 0 20.0532925626374 1 2818.5 4975 False False 0 0 1.2354962611609 0 0 0.00038900558066021 0.999635905335387 0.999377467513205 0.999806121137399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 12 6560 26493 0 0 0.000562171107654053 0.999547255234861 0.999209279704825 0.999766038988972 0 0 0.264648469397051 0 0 0.841886116991581 0 0 0.264648469397051 0 0 21.5100409924858 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 1.45386850159099 0 0 0.000562171107654053 0.999547255234861 0.999209279704825 0.999766038988972 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.1983T>C embC_c.1983T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.198G>A embC_c.198G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-198G>T embC_c.-198G>T 1 upstream_gene_variant 4239665 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.1992A>C embC_c.1992A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.1998C>T embC_c.1998C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.10982832991351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-1G>A embC_c.-1G>A 1 upstream_gene_variant 4239862 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.2004G>T embC_c.2004G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2007G>A embC_c.2007G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2010G>C embC_c.2010G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2011C>T embC_c.2011C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2013G>A embC_c.2013G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2017C>T embC_c.2017C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-201G>A embC_c.-201G>A 1 upstream_gene_variant 4239662 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.2022G>A embC_c.2022G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.19822685561766 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.40943166615857 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2023C>T embC_c.2023C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2028G>C embC_c.2028G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2031A>G embC_c.2031A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.204C>T embC_c.204C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2052C>T embC_c.2052C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2055T>C embC_c.2055T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2073C>T embC_c.2073C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-207C>T embC_c.-207C>T 1 upstream_gene_variant 4239656 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3880 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethambutol embC c.207T>C embC_c.207T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-208C>T embC_c.-208C>T 1 upstream_gene_variant 4239655 1 23 2 21 2 26 9479 35679 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999271810670774 0.99893321465683 0.999524269143814 0.0714285714285714 0.00877049670352713 0.23503477317459 0.0869565217391304 0.0107099660378758 0.280379335909411 0.0714285714285714 0.00877049670352713 0.23503477317459 0.358476632556176 0.0407439793066752 1.46704960355696 0.200977228499246 162 4975 False False 0.289538818603065 0.0332927686503541 1.15683883914407 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999271810670774 0.99893321465683 0.999524269143814 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 20 1 19 1 23 6559 26482 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.99913223920015 0.998698215498625 0.999449837068455 0.0416666666666666 0.00105435244546974 0.211201683456973 0.05 0.0012650894979498 0.248732762772027 0.0416666666666666 0.00105435244546974 0.211201683456973 0.212500300912366 0.00511709932656809 1.33728199912397 0.154955779121429 117 4087 False False 0 0 0 0 0 0 0 0.17554372684065 0.00426447449683549 1.0814738397624999 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.99913223920015 0.998698215498625 0.999449837068455 1 3) Uncertain significance No change no 1 +Ethambutol embC c.-209C>G embC_c.-209C>G 1 upstream_gene_variant 4239654 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3930 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3247 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-209C>T embC_c.-209C>T 1 upstream_gene_variant 4239654 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 2 3) Uncertain significance No change no 1 +Ethambutol embC c.-20A>C embC_c.-20A>C 1 upstream_gene_variant 4239843 0 0 0 0 16 57 9465 35648 0.00168758569771121 0.00096489905765009 0.00273909056442828 0.998403584932082 0.997932147274224 0.998790673486123 0.21917808219178 0.130780746969945 0.331384004620654 NA NA NA 0 0 0.0626674809144849 NA NA NA NA NA NA False True 1.05720614266781 0.566409119807667 1.86771930036243 0 0 0.000389663042518041 0.998403584932082 0.997932147274224 0.998790673486123 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 16 56 6544 26449 0.0024390243902439 0.00139473586445882 0.00395780883041526 0.997887191096019 0.997257207571945 0.99840362427984 0.222222222222222 0.13268238478784 0.335636627854692 NA NA NA 0 0 0.0637500966623622 NA NA NA NA NA NA False True 0 0 1 0 0 1 1 1.15477645826056 0.617855593382972 2.043396905127 0 0 0.000563545221770202 0.997887191096019 0.997257207571945 0.99840362427984 4 Not assoc w R Literature evidence (PMID 32143680) 4) Not assoc w R - Interim DOWN from NotAwR to NotAwRI yes Lit. (PMID 32143680) 3 +Ethambutol embC c.2100A>G embC_c.2100A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2112C>A embC_c.2112C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 1 9479 35704 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999971992718106 0.999843963402622 0.999999290917266 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 7.53328410169849 0.392120325718966 443.147628387906 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-211T>G embC_c.-211T>G 1 upstream_gene_variant 4239652 1 14 0 14 0 21 9481 35684 0 0 0.00038900558066021 0.99941184708024 0.99910108554872 0.999635888372764 0 0 0.161097615219079 0 0 0.231635761650116 0 0 0.161097615219079 0 0 1.1348880636459 0.0520754293355741 93 4975 False False 0 0 0.722928583272661 0 0 0.00038900558066021 0.99941184708024 0.99910108554872 0.999635888372764 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 0 16 6560 26489 0 0 0.000562171107654053 0.999396340313148 0.99901987910474 0.999654918214049 0 0 0.205907214207822 0 0 0.30849710781876 0 0 0.205907214207822 0 0 1.80207321067052 0.227556871835103 179 4087 False False 0 0 0 0 0 0 0 0 0 1.047384092264 0 0 0.000562171107654053 0.999396340313148 0.99901987910474 0.999654918214049 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.2121G>A embC_c.2121G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.707313928675496 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2122T>C embC_c.2122T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-212C>T embC_c.-212C>T 1 upstream_gene_variant 4239651 1 2 0 2 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0615661524565 1 2818.5 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.5214194708504 1 2276.5 4087 False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 0 0 0.000562256793434776 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.2133C>A embC_c.2133C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2143C>T embC_c.2143C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2148G>A embC_c.2148G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2157G>A embC_c.2157G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2163A>G embC_c.2163A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2167C>T embC_c.2167C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 4 78 9477 35627 0.000421896424427802 0.000114964157806894 0.00107986688593449 0.997815432012323 0.997274299230959 0.998272818348699 0.048780487804878 0.0134490336528281 0.120211762214449 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.192785231721604 0.0512085810469042 0.513874001225871 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 4 73 6556 26432 0.000609756097560975 0.000166162208307701 0.00156047520083291 0.99724580267874 0.996538238164594 0.997840546509499 0.0519480519480519 0.014333514116461 0.127698603752203 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.220916529457487 0.0585887965039859 0.590554224714942 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2175G>A embC_c.2175G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2196G>A embC_c.2196G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-21C>A embC_c.-21C>A 1 upstream_gene_variant 4239842 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3828 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3164 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.2211C>T embC_c.2211C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2214G>A embC_c.2214G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2220C>T embC_c.2220C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2221C>T embC_c.2221C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.10982832991351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.40943166615857 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2226G>A embC_c.2226G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-222G>A embC_c.-222G>A 1 upstream_gene_variant 4239641 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.2232G>A embC_c.2232G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2244C>T embC_c.2244C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2256C>G embC_c.2256C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-225C>A embC_c.-225C>A 1 upstream_gene_variant 4239638 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.2277G>A embC_c.2277G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2286C>T embC_c.2286C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.88306962025316 0.0319145727646777 36.1783621216076 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2289A>G embC_c.2289A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2292C>A embC_c.2292C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-22G>A embC_c.-22G>A 1 upstream_gene_variant 4239841 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4041 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3342 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.2301G>A embC_c.2301G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 8 9481 35697 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.20624116275339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-230A>G embC_c.-230A>G 1 upstream_gene_variant 4239633 1 8 0 8 2 10 9479 35695 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999719927181067 0.999484996631079 0.999865686288203 0.166666666666666 0.0208625254600923 0.484137748685967 0 0 0.369416647552819 0 0 0.30849710781876 0 0 2.20658330541233 0.217694648178992 234 4975 False False 0.753138516721173 0.0802222726697143 3.53509134535146 0 0 0.000389087642036349 0.999719927181067 0.999484996631079 0.999865686288203 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 1 9 6559 26496 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999660441426146 0.999355510362951 0.999844720818052 0.1 0.00252857854446178 0.445016117028195 0 0 0.409616397225003 0 0 0.336267116879942 0 0 2.80349186567692 0.357907372339334 215 4087 False False 0 0 0 0 0 0 0 0.448848909894801 0.0102423495192947 3.24032619577018 0 0 0.000562256793434776 0.999660441426146 0.999355510362951 0.999844720818052 1 3) Uncertain significance No change no 1 +Ethambutol embC c.2313G>T embC_c.2313G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2316G>A embC_c.2316G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 9478 35705 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 1 0.999896689850119 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.55639137151076 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 6557 26505 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 1 0.999860832946126 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.66990152933523 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.231C>T embC_c.231C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2328C>T embC_c.2328C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2370T>C embC_c.2370T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 3 9480 35702 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99991597815432 0.999754472342108 0.99998267234027 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.25534458509142 0.0239099774609589 15.6346568618898 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2379C>T embC_c.2379C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 5 25 9476 35680 0.000527370530534753 0.000171257241502832 0.00123027414547083 0.999299817952667 0.998966565499085 0.999546829455204 0.166666666666666 0.0564216964680715 0.347211698834143 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.753060363022372 0.225073153157771 2.00357763533127 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 4 13 6556 26492 0.000609756097560975 0.000166162208307701 0.00156047520083291 0.999509526504433 0.999161421428146 0.999738818498366 0.235294117647058 0.0681077404373566 0.49899327320458 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.24334725677007 0.295227743737109 4.02644777576783 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2397G>A embC_c.2397G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.240C>G embC_c.240C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 13 9480 35692 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999635905335387 0.999377467513205 0.999806121137399 0.0714285714285714 0.00180678065912538 0.338684489931821 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.28961376176566 0.00681762323326769 1.92866803203756 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 13 6559 26492 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999509526504433 0.999161421428146 0.999738818498366 0.0714285714285714 0.00180678065912538 0.338684489931821 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.310694641537757 0.0073132274312288 2.06928814207562 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2418C>T embC_c.2418C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2421T>C embC_c.2421T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2427C>T embC_c.2427C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-242G>A embC_c.-242G>A 1 upstream_gene_variant 4239621 0 0 0 0 3 2 9478 35703 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999943985436213 0.999797670939776 0.99999321630447 0.6 0.146632799634673 0.947255049473683 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3786 4975 False False 5.65040092846592 0.647137685918782 67.7491623796885 0 0 0.000389128685709026 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.246G>A embC_c.246G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2475C>T embC_c.2475C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.76624472573839 0.0479745002090283 294.932792118969 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2481G>A embC_c.2481G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2484C>T embC_c.2484C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2487A>C embC_c.2487A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2490G>A embC_c.2490G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.249C>T embC_c.249C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.707313928675496 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2508C>G embC_c.2508C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2511C>A embC_c.2511C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2517G>A embC_c.2517G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2526C>T embC_c.2526C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 14 9481 35691 0 0 0.00038900558066021 0.999607898053494 0.999342206985133 0.999785618166341 0 0 0.231635761650116 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.13511057396106 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 8 6560 26497 0 0 0.000562171107654053 0.999698170156574 0.999405361976814 0.999869682578628 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.36695385477914 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2535G>A embC_c.2535G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2535G>T embC_c.2535G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2538C>A embC_c.2538C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2541T>C embC_c.2541T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2544A>C embC_c.2544A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2547G>T embC_c.2547G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.19822685561766 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 6 6560 26499 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.43165838346939 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2550G>C embC_c.2550G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.255C>T embC_c.255C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2574G>A embC_c.2574G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2574G>T embC_c.2574G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.76624472573839 0.0479745002090283 294.932792118969 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2580G>A embC_c.2580G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 6 9480 35699 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99983195630864 0.999634275787128 0.999938328510354 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.627619549929676 0.0136468000350686 5.17448319653473 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 4 6559 26501 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999849085078287 0.999613643356053 0.999958879281354 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.01010062509528 0.0205075656450505 10.2127021503241 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2586C>T embC_c.2586C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2592G>A embC_c.2592G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2611C>T embC_c.2611C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2613G>A embC_c.2613G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 10 9481 35695 0 0 0.00038900558066021 0.999719927181067 0.999484996631079 0.999865686288203 0 0 0.30849710781876 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.67996531074212 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 8 6560 26497 0 0 0.000562171107654053 0.999698170156574 0.999405361976814 0.999869682578628 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.36695385477914 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2628G>A embC_c.2628G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2631G>C embC_c.2631G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2635A>C embC_c.2635A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2658G>C embC_c.2658G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.707313928675496 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2676C>T embC_c.2676C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2688C>G embC_c.2688C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 275 9480 35430 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.992297997479344 0.991335998397384 0.99317856568895 0.0036231884057971 9.17269811720626e-05 0.0200207158166085 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.0135903337169159 0.000347898868809463 0.0763854411259278 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 1 196 6559 26309 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.992605168836068 0.991499016367306 0.99360116040857 0.00507614213197969 0.000128508533869303 0.027956460269938 NA NA NA NA NA NA NA NA NA NA NA NA False True 1 1 1 0 0 0 1 0.0204649476805511 0.000520153845310437 0.115401917588439 NA NA NA NA NA NA 21 5) Not assoc w R Now listed Silent mutation no 0 +Ethambutol embC c.2688C>T embC_c.2688C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-268T>C embC_c.-268T>C 1 upstream_gene_variant 4239595 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.2691G>C embC_c.2691G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 6 2 9475 35703 0.000632844636641704 0.000232277107744303 0.00137692358870305 0.999943985436213 0.999797670939776 0.99999321630447 0.75 0.349144205587175 0.968145973750055 NA NA NA NA NA NA NA NA NA NA NA NA False False 11.3043799472295 2.02076681289593 114.60971106128 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 6 0 6554 26505 0.000914634146341463 0.000335726224038477 0.00198970246660848 1 0.999860832946126 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 4.75965536954277 Inf NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2694G>A embC_c.2694G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2697G>A embC_c.2697G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-26A>G embC_c.-26A>G 1 upstream_gene_variant 4239837 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.2709C>T embC_c.2709C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-270G>A embC_c.-270G>A 1 upstream_gene_variant 4239593 1 1 0 1 7 78 9474 35627 0.000738318742748655 0.00029689231210758 0.00152062336565454 0.997815432012323 0.997274299230959 0.998272818348699 0.0823529411764705 0.0337525436178748 0.162343904723825 0 0 0.975 0 0 0.0461924203280487 0 0 146.330663280295 1 NA NA False True 0.337480987100999 0.131316129470683 0.729163846619271 0 0 0.000389292947027732 0.997815432012323 0.997274299230959 0.998272818348699 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 1 0 1 5 64 6555 26441 0.000762195121951219 0.000247527523788107 0.00177780526826415 0.997585361252594 0.99691759169954 0.998139952534465 0.072463768115942 0.0239466209687045 0.161061740273612 0 0 0.975 0 0 0.0560090893866365 0 0 156.937501930086 1 NA NA False True 0 1 1 0 0 1 0 0.315133962623951 0.0989253218388498 0.774901564153002 0 0 0.00056259979792051 0.997585361252594 0.99691759169954 0.998139952534465 25 Not assoc w R 5) Not assoc w R No change yes 1 +Ethambutol embC c.2733C>T embC_c.2733C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-274C>T embC_c.-274C>T 1 upstream_gene_variant 4239589 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3733 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.2760C>T embC_c.2760C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2775C>T embC_c.2775C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2781C>T embC_c.2781C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 9362 34923 119 782 0.987448581373272 0.984998933766136 0.989591500498826 0.0219016944405545 0.0204085283432073 0.0234733122322412 0.211403409732415 0.207608333697045 0.215236356192129 NA NA NA NA NA NA NA NA NA NA NA NA False True 1.76163887082193 1.44883227933598 2.1576832709232 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 6457 25810 103 695 0.984298780487804 0.980989602198811 0.987166556040844 0.0262214676476136 0.024330957754333 0.028216782861074 0.20011156909536 0.195757858702152 0.20451932922721 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 1 1.68806965013184 1.36809219821196 2.10071756178742 NA NA NA NA NA NA 6999 5) Not assoc w R Now listed Silent mutation no 0 +Ethambutol embC c.2787G>A embC_c.2787G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-278G>A embC_c.-278G>A 1 upstream_gene_variant 4239585 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.2799G>A embC_c.2799G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-279C>A embC_c.-279C>A 1 upstream_gene_variant 4239584 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-27C>T embC_c.-27C>T 1 upstream_gene_variant 4239836 1 1 0 1 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 146.529978407112 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3283 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.2808C>A embC_c.2808C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-281C>T embC_c.-281C>T 1 upstream_gene_variant 4239582 1 4 1 3 1 3 9480 35702 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99991597815432 0.999754472342108 0.99998267234027 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 1.25534458509142 0.0239099774609589 15.6346568618898 1 2818.5 4975 False False 1.25534458509142 0.0239099774609589 15.6346568618898 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embC c.2830C>A embC_c.2830C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2835G>A embC_c.2835G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.88306962025316 0.0319145727646777 36.1783621216076 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2850G>A embC_c.2850G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.76624472573839 0.0479745002090283 294.932792118969 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2853T>C embC_c.2853T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2856G>A embC_c.2856G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2868C>T embC_c.2868C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2889G>A embC_c.2889G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-288C>T embC_c.-288C>T 1 upstream_gene_variant 4239575 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.2890C>A embC_c.2890C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-28C>G embC_c.-28C>G 1 upstream_gene_variant 4239835 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.2901G>A embC_c.2901G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2904G>A embC_c.2904G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.88306962025316 0.0319145727646777 36.1783621216076 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2913G>A embC_c.2913G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 8 9481 35697 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.20624116275339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2916G>A embC_c.2916G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2919C>T embC_c.2919C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.19822685561766 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.291G>A embC_c.291G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.88306962025316 0.0319145727646777 36.1783621216076 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2925G>C embC_c.2925G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2931A>C embC_c.2931A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2934G>A embC_c.2934G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2940G>A embC_c.2940G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2946C>T embC_c.2946C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-294A>G embC_c.-294A>G 1 upstream_gene_variant 4239569 1 3 0 3 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 9.1150193618684 1 2818.5 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 9.77910191708565 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 1 3) Uncertain significance No change no 1 +Ethambutol embC c.-295C>T embC_c.-295C>T 1 upstream_gene_variant 4239568 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.2973C>T embC_c.2973C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 3 9479 35702 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.99991597815432 0.999754472342108 0.99998267234027 0.4 0.0527449505263169 0.853367200365326 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.51095403875232 0.209684820120099 21.9222407664312 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 2 3 6558 26502 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999886813808715 0.999669257903365 0.999976657677988 0.4 0.0527449505263169 0.853367200365326 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.69411405916437 0.224966079471659 23.5225659748306 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2979C>T embC_c.2979C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-297G>A embC_c.-297G>A 1 upstream_gene_variant 4239566 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3215 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.2985C>G embC_c.2985C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2988G>A embC_c.2988G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2994C>A embC_c.2994C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.2994C>G embC_c.2994C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.300C>A embC_c.300C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.19822685561766 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.40943166615857 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.300C>T embC_c.300C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 8 9481 35697 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.20624116275339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 8 6560 26497 0 0 0.000562171107654053 0.999698170156574 0.999405361976814 0.999869682578628 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.36695385477914 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.3015G>A embC_c.3015G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.19822685561766 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 6 6560 26499 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.43165838346939 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.3021C>G embC_c.3021C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.3021C>T embC_c.3021C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 21 9481 35684 0 0 0.00038900558066021 0.99941184708024 0.99910108554872 0.999635888372764 0 0 0.161097615219079 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.722928583272661 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 18 6560 26487 0 0 0.000562171107654053 0.999320882852292 0.998926913664084 0.999597464048431 0 0 0.185301968137852 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.918654117939294 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.3039G>A embC_c.3039G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.303C>T embC_c.303C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.3042C>T embC_c.3042C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-304A>C embC_c.-304A>C 1 upstream_gene_variant 4239559 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.3060C>T embC_c.3060C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.3066A>G embC_c.3066A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 6 34 9475 35671 0.000632844636641704 0.000232277107744303 0.00137692358870305 0.999047752415628 0.998669581250379 0.999340453530361 0.15 0.0571022581545258 0.298352666839576 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.664367530653422 0.227927415178877 1.60149324401174 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 5 29 6555 26476 0.000762195121951219 0.000247527523788107 0.00177780526826415 0.998905866817581 0.998429017222443 0.999267123212173 0.147058823529411 0.0495284552561774 0.310565730395125 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.696388647781372 0.210393082848549 1.82040871104596 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.3072G>A embC_c.3072G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.3096G>A embC_c.3096G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.3099G>A embC_c.3099G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.3108C>A embC_c.3108C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.3108C>T embC_c.3108C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 8 220 9473 35485 0.000843792848855605 0.000364358012393849 0.00166192766222289 0.993838397983475 0.99297121227786 0.994623709560161 0.0350877192982456 0.0152679074396009 0.0679636174375084 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.136214888246979 0.0580842881372039 0.273296946543406 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 6 204 6554 26301 0.000914634146341463 0.000335726224038477 0.00198970246660848 0.992303338992642 0.991176584751054 0.993320049994526 0.0285714285714285 0.0105559023479763 0.0611475991934364 NA NA NA NA NA NA NA NA NA NA NA NA False True 1 1 1 0 0 0 1 0.118028505268448 0.0427975522248809 0.261517781300314 NA NA NA NA NA NA 15 5) Not assoc w R Now listed Silent mutation no 0 +Ethambutol embC c.3117G>A embC_c.3117G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-312C>T embC_c.-312C>T 1 upstream_gene_variant 4239551 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-314C>A embC_c.-314C>A 1 upstream_gene_variant 4239549 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.3189G>A embC_c.3189G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-318G>A embC_c.-318G>A 1 upstream_gene_variant 4239545 1 1 0 1 1 3 9480 35702 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99991597815432 0.999754472342108 0.99998267234027 0.25 0.00630946320970987 0.805879550316756 0 0 0.975 0 0 0.707598226178713 0 0 146.545399763461 1 2818.5 4975 False False 1.25534458509142 0.0239099774609589 15.6346568618898 0 0 0.00038904660702099 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 157.208880998325 1 2276.5 4087 False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 0 0 0.000562256793434776 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.3204C>T embC_c.3204C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-320A>G embC_c.-320A>G 1 upstream_gene_variant 4239543 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.3219T>G embC_c.3219T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-321G>T embC_c.-321G>T 1 upstream_gene_variant 4239542 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.3225G>A embC_c.3225G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 6 9480 35699 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99983195630864 0.999634275787128 0.999938328510354 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.627619549929676 0.0136468000350686 5.17448319653473 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 4 6559 26501 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999849085078287 0.999613643356053 0.999958879281354 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.01010062509528 0.0205075656450505 10.2127021503241 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.3225G>T embC_c.3225G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.3228C>T embC_c.3228C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-322T>C embC_c.-322T>C 1 upstream_gene_variant 4239541 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.3231A>C embC_c.3231A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.88306962025316 0.0319145727646777 36.1783621216076 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.3237G>T embC_c.3237G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.3249C>T embC_c.3249C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.3252G>T embC_c.3252G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-325G>A embC_c.-325G>A 1 upstream_gene_variant 4239538 1 3 2 1 3 1 9478 35704 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999971992718106 0.999843963402622 0.999999290917266 0.75 0.194120449683243 0.99369053679029 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 7.53407891960329 0.392161721905024 443.194232299038 0.113576717466983 131.5 4975 False False 11.3011183794049 0.90722384791697 591.183089908516 0.000210970464135021 2.55505231929967e-05 0.00076188787765788 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 2 1 3 1 6557 26504 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 0.999962271269571 0.999789807096406 0.999999044791703 0.75 0.194120449683243 0.99369053679029 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 8.08418484062833 0.420783807737339 475.445913006495 0.102434008199309 98 4087 False False 0 0 0 0 0 0 0 12.1262772609425 0.973374031902014 634.171386087929 0.000304924531178533 3.69299088044271e-05 0.00110105363070902 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.3264G>A embC_c.3264G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.3267G>A embC_c.3267G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-329C>A embC_c.-329C>A 1 upstream_gene_variant 4239534 1 2 0 2 1 4 9480 35701 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999887970872426 0.999713186009257 0.999969475016731 0.2 0.00505076337946806 0.716417936118089 0 0 0.841886116991581 0 0 0.602364635616474 0 0 20.0604454397456 1 2818.5 4975 False False 0.941482067510548 0.0191153149568561 9.51304376083015 0 0 0.00038904660702099 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 3 6559 26502 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999886813808715 0.999669257903365 0.999976657677988 0.25 0.00630946320970987 0.805879550316756 0 0 0.975 0 0 0.707598226178713 0 0 157.202964052604 1 2276.5 4087 False False 0 0 0 0 0 0 0 1.34685165421558 0.025651688752077 16.7753654027497 0 0 0.000562256793434776 0.999886813808715 0.999669257903365 0.999976657677988 1 3) Uncertain significance No change no 1 +Ethambutol embC c.330C>G embC_c.330C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-333C>T embC_c.-333C>T 1 upstream_gene_variant 4239530 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.333G>A embC_c.333G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-334G>A embC_c.-334G>A 1 upstream_gene_variant 4239529 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4015 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-334G>T embC_c.-334G>T 1 upstream_gene_variant 4239529 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-335G>A embC_c.-335G>A 1 upstream_gene_variant 4239528 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.336G>A embC_c.336G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.76624472573839 0.0479745002090283 294.932792118969 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.339G>A embC_c.339G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.33C>T embC_c.33C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-33G>T embC_c.-33G>T 1 upstream_gene_variant 4239830 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-340A>G embC_c.-340A>G 1 upstream_gene_variant 4239523 1 3 1 2 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 1.88306962025316 0.0319145727646777 36.1783621216076 0.506635653517051 355 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-341T>G embC_c.-341T>G 1 upstream_gene_variant 4239522 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-342C>A embC_c.-342C>A 1 upstream_gene_variant 4239521 1 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 157.21479794295 1 1103 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embC c.-342C>G embC_c.-342C>G 1 upstream_gene_variant 4239521 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.342T>A embC_c.342T>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.342T>C embC_c.342T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-343C>T embC_c.-343C>T 1 upstream_gene_variant 4239520 1 3 0 3 1 3 9480 35702 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99991597815432 0.999754472342108 0.99998267234027 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11649128277037 1 2818.5 4975 False False 1.25534458509142 0.0239099774609589 15.6346568618898 0 0 0.00038904660702099 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-344C>T embC_c.-344C>T 1 upstream_gene_variant 4239519 0 0 0 0 3 0 9478 35705 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 1 0.999896689850119 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3756 4975 False False Inf 1.55639137151076 Inf 0 0 0.000389128685709026 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 6557 26505 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 1 0.999860832946126 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3098 4087 False False 0 0 0 0 0 0 0 Inf 1.66990152933523 Inf 0 0 0.000562428243381166 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.345G>A embC_c.345G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 41 9479 35664 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.998851701442375 0.998442522346295 0.999175839019405 0.0465116279069767 0.00568325697874796 0.158111458308697 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.183532790069962 0.0215026647461569 0.706837492751646 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 2 32 6558 26473 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.998792680626296 0.998296048910783 0.999174052431467 0.0588235294117647 0.00720491743904971 0.196773209335575 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.252296813052759 0.0292904149343182 0.989374020315091 NA NA NA NA NA NA 12 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-351G>A embC_c.-351G>A 1 upstream_gene_variant 4239512 1 4 0 4 2 4 9479 35701 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999887970872426 0.999713186009257 0.999969475016731 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70635720483655 0.585912512864505 454 4975 False False 1.88316278088405 0.170308362439121 13.1422755166224 0 0 0.000389087642036349 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 2 4 6558 26501 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999849085078287 0.999613643356053 0.999958879281354 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12290791020688 1 1103 4087 False False 0 0 0 0 0 0 0 2.02050930161634 0.182720640564327 14.1017085588021 0 0 0.00056234250533983 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-351G>C embC_c.-351G>C 1 upstream_gene_variant 4239512 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3775 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3115 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-354G>A embC_c.-354G>A 1 upstream_gene_variant 4239509 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-355T>G embC_c.-355T>G 1 upstream_gene_variant 4239508 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-356C>A embC_c.-356C>A 1 upstream_gene_variant 4239507 1 4 0 4 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 0 0 0.602364635616474 0 0 0.4592581264399 0 0 5.70483372250837 0.585894740941386 369 4975 False False 0 0 3.19822685561766 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 6.12080991862283 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.363G>A embC_c.363G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.363G>T embC_c.363G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-371G>T embC_c.-371G>T 1 upstream_gene_variant 4239492 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4008 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3316 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-372C>T embC_c.-372C>T 1 upstream_gene_variant 4239491 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.375G>C embC_c.375G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-376T>C embC_c.-376T>C 1 upstream_gene_variant 4239487 1 4 0 4 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 5.70499352101301 0.585896604883905 379.5 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.77947080093164 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 1 3) Uncertain significance No change no 1 +Ethambutol embC c.-378G>A embC_c.-378G>A 1 upstream_gene_variant 4239485 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3938 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3254 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.381C>T embC_c.381C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-382T>C embC_c.-382T>C 1 upstream_gene_variant 4239481 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-383G>A embC_c.-383G>A 1 upstream_gene_variant 4239480 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4061 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-384C>T embC_c.-384C>T 1 upstream_gene_variant 4239479 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-387G>T embC_c.-387G>T 1 upstream_gene_variant 4239476 1 11 1 10 3 13 9478 35692 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999635905335387 0.999377467513205 0.999806121137399 0.1875 0.0404737339059459 0.456456546231611 0.0909090909090909 0.00229897221381426 0.412779916988382 0.0714285714285714 0.00180678065912538 0.338684489931821 0.376577336990926 0.00867994887086088 2.64773575170521 0.477503335604889 345 4975 False False 0.869024623825214 0.158797207105976 3.16336401869717 0.000105496360375567 2.67093302808208e-06 0.000587646375974446 0.999635905335387 0.999377467513205 0.999806121137399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 1 7 3 9 6557 26496 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 0.999660441426146 0.999355510362951 0.999844720818052 0.25 0.0548606445279927 0.571858461878189 0.125 0.0031597235312519 0.526509670875206 0.1 0.00252857854446178 0.445016117028195 0.577267478594304 0.0128100813491463 4.49464468831296 1 2276.5 4087 False False 0 0 0 0 0 0 0 1.34695745005337 0.234479688503756 5.39893908273865 0.000152485513876181 3.86059150860036e-06 0.000849298834468653 0.999660441426146 0.999355510362951 0.999844720818052 1 3) Uncertain significance No change no 1 +Ethambutol embC c.-388G>A embC_c.-388G>A 1 upstream_gene_variant 4239475 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embC c.-38T>C embC_c.-38T>C 1 upstream_gene_variant 4239825 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3829 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3165 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-390T>C embC_c.-390T>C 1 upstream_gene_variant 4239473 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3804 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3141 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-393C>A embC_c.-393C>A 1 upstream_gene_variant 4239470 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3857 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.393G>A embC_c.393G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-394G>A embC_c.-394G>A 1 upstream_gene_variant 4239469 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-394G>C embC_c.-394G>C 1 upstream_gene_variant 4239469 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-395C>G embC_c.-395C>G 1 upstream_gene_variant 4239468 1 0 0 0 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3949 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3264 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-397G>A embC_c.-397G>A 1 upstream_gene_variant 4239466 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.39G>A embC_c.39G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.402G>A embC_c.402G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-403G>A embC_c.-403G>A 1 upstream_gene_variant 4239460 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3900 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3221 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-403G>C embC_c.-403G>C 1 upstream_gene_variant 4239460 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3991 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3301 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-405C>G embC_c.-405C>G 1 upstream_gene_variant 4239458 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3979 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3292 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-413C>T embC_c.-413C>T 1 upstream_gene_variant 4239450 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-425G>A embC_c.-425G>A 1 upstream_gene_variant 4239438 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethambutol embC c.-426T>C embC_c.-426T>C 1 upstream_gene_variant 4239437 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3931 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.429G>A embC_c.429G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.432G>A embC_c.432G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-435A>G embC_c.-435A>G 1 upstream_gene_variant 4239428 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3787 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-440T>C embC_c.-440T>C 1 upstream_gene_variant 4239423 1 2 0 2 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 20.058335224773 1 1480 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 157.179059039538 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 1 3) Uncertain significance No change no 1 +Ethambutol embC c.-444G>A embC_c.-444G>A 1 upstream_gene_variant 4239419 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-447G>A embC_c.-447G>A 1 upstream_gene_variant 4239416 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-454G>A embC_c.-454G>A 1 upstream_gene_variant 4239409 1 1 0 1 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 146.525883667094 1 2818.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3307 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-455G>A embC_c.-455G>A 1 upstream_gene_variant 4239408 1 3 0 3 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.11527461591697 1 2818.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.77947080093164 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-457C>A embC_c.-457C>A 1 upstream_gene_variant 4239406 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3950 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.459G>A embC_c.459G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-459G>A embC_c.-459G>A 1 upstream_gene_variant 4239404 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.45A>C embC_c.45A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-45T>C embC_c.-45T>C 1 upstream_gene_variant 4239818 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4042 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3343 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-460C>T embC_c.-460C>T 1 upstream_gene_variant 4239403 1 2 0 2 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.058895521352 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.462G>A embC_c.462G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.462G>C embC_c.462G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.465G>A embC_c.465G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 4 9479 35701 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999887970872426 0.999713186009257 0.999969475016731 0.333333333333333 0.0432718682927417 0.777221904496487 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.88316278088405 0.170308362439121 13.1422755166224 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-465G>A embC_c.-465G>A 1 upstream_gene_variant 4239398 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-467C>A embC_c.-467C>A 1 upstream_gene_variant 4239396 1 34 1 33 2 38 9479 35667 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.998935723288054 0.998539486720009 0.99924674779982 0.05 0.00611364659935083 0.169196863959417 0.0294117647058823 0.00074436423469026 0.153267669560317 0.0256410256410256 0.000648963895481945 0.134763921559497 0.114022384409556 0.00280650294964348 0.68129957529764 0.00536250374575721 47 4975 False False 0.198038878185018 0.0231591448017876 0.766559502535627 0.00010548523206751 2.670651284468e-06 0.000587584402906152 0.998935723288054 0.998539486720009 0.99924674779982 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 28 1 27 2 29 6558 26476 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.998905866817581 0.998429017222443 0.999267123212173 0.064516129032258 0.0079109834618547 0.214216157163402 0.0357142857142857 0.000903798755658059 0.183477597544623 0.0333333333333333 0.000843570926630479 0.172169455633412 0.149526165384658 0.0036553083352333 0.90757620275975 0.0301643439374393 54 4087 False False 0 0 0 0 0 0 0 0.278428032095571 0.0321820345249674 1.10110840479394 0.000152462265589266 3.86000291520843e-06 0.000849169393567967 0.998905866817581 0.998429017222443 0.999267123212173 12 3) Uncertain significance No change no 1 +Ethambutol embC c.-470G>T embC_c.-470G>T 1 upstream_gene_variant 4239393 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3734 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3082 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.471C>T embC_c.471C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-474C>A embC_c.-474C>A 1 upstream_gene_variant 4239389 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3912 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3230 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-475G>C embC_c.-475G>C 1 upstream_gene_variant 4239388 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-476C>G embC_c.-476C>G 1 upstream_gene_variant 4239387 1 0 0 0 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3901 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3222 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.480C>T embC_c.480C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-481G>C embC_c.-481G>C 1 upstream_gene_variant 4239382 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-481G>T embC_c.-481G>T 1 upstream_gene_variant 4239382 0 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3939 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3255 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 1 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-482G>A embC_c.-482G>A 1 upstream_gene_variant 4239381 1 37 1 36 4 39 9477 35666 0.000421896424427802 0.000114964157806894 0.00107986688593449 0.998907716006161 0.998507111173478 0.999223167585189 0.0930232558139534 0.0259312902663234 0.221353445381386 0.027027027027027 0.000684031024694665 0.141603095611158 0.025 0.000632744932049419 0.131585858482765 0.104539645691909 0.00257968827195825 0.621027928884998 0.00365047571202896 39 4975 False False 0.385992537939356 0.100150643644821 1.07027616505522 0.000105507491031863 2.67121483114821e-06 0.000587708362116832 0.998907716006161 0.998507111173478 0.999223167585189 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 16 0 16 2 18 6558 26487 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999320882852292 0.998926913664084 0.999597464048431 0.1 0.0123485271702948 0.316982714019082 0 0 0.205907214207822 0 0 0.185301968137852 0 0 1.0476244911349 0.0545749494823402 74.5 4087 False False 0 0 0 0 0 0 0 0.448764867337602 0.0504895302137191 1.87519985544009 0 0 0.00056234250533983 0.999320882852292 0.998926913664084 0.999597464048431 9 3) Uncertain significance No change no 1 +Ethambutol embC c.483C>T embC_c.483C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-483C>T embC_c.-483C>T 1 upstream_gene_variant 4239380 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3881 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.486T>C embC_c.486T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-487G>C embC_c.-487G>C 1 upstream_gene_variant 4239376 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4009 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-48C>T embC_c.-48C>T 1 upstream_gene_variant 4239815 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3816 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3153 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-491G>A embC_c.-491G>A 1 upstream_gene_variant 4239372 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3776 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-495C>A embC_c.-495C>A 1 upstream_gene_variant 4239368 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-495C>T embC_c.-495C>T 1 upstream_gene_variant 4239368 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-496A>C embC_c.-496A>C 1 upstream_gene_variant 4239367 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-497G>A embC_c.-497G>A 1 upstream_gene_variant 4239366 1 1 0 1 3 3 9478 35702 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.99991597815432 0.999754472342108 0.99998267234027 0.5 0.118117248757025 0.881882751242974 0 0 0.975 0 0 0.707598226178713 0 0 146.576252216211 1 2818.5 4975 False False 3.76682844481958 0.504418797674528 28.1425087484132 0 0 0.000389128685709026 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.498C>T embC_c.498C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-498C>T embC_c.-498C>T 1 upstream_gene_variant 4239365 2 2 0 2 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0615661524565 1 2818.5 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 2 0 2 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.5214194708504 1 2276.5 4087 False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 0 0 0.000562256793434776 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-499C>G embC_c.-499C>G 1 upstream_gene_variant 4239364 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-4C>G embC_c.-4C>G 1 upstream_gene_variant 4239859 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-503T>G embC_c.-503T>G 1 upstream_gene_variant 4239360 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3970 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3284 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embC c.504C>T embC_c.504C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-506G>T embC_c.-506G>T 1 upstream_gene_variant 4239357 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3841 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3177 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-509A>G embC_c.-509A>G 1 upstream_gene_variant 4239354 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 2 3) Uncertain significance No change no 1 +Ethambutol embC c.-50G>A embC_c.-50G>A 1 upstream_gene_variant 4239813 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.510A>G embC_c.510A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 5 5 9476 35700 0.000527370530534753 0.000171257241502832 0.00123027414547083 0.999859963590533 0.999673232250017 0.999954529045718 0.5 0.187086028447398 0.812913971552601 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.7674124102997 0.866815029288652 16.380547623516 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 5 5 6555 26500 0.000762195121951219 0.000247527523788107 0.00177780526826415 0.999811356347858 0.999559824020536 0.9999387451734 0.5 0.187086028447398 0.812913971552601 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.04271548436308 0.930054868102617 17.5613448179105 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-510C>T embC_c.-510C>T 1 upstream_gene_variant 4239353 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.511C>T embC_c.511C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 11 9481 35694 0 0 0.00038900558066021 0.999691919899173 0.999448826618347 0.999846197812 0 0 0.284914152918154 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.50034693324555 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 9 6560 26496 0 0 0.000562171107654053 0.999660441426146 0.999355510362951 0.999844720818052 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.04691100627475 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-513G>A embC_c.-513G>A 1 upstream_gene_variant 4239350 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-516C>T embC_c.-516C>T 1 upstream_gene_variant 4239347 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.51C>G embC_c.51C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-521C>G embC_c.-521C>G 1 upstream_gene_variant 4239342 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3830 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3166 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-521C>T embC_c.-521C>T 1 upstream_gene_variant 4239342 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.522A>C embC_c.522A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-523G>C embC_c.-523G>C 1 upstream_gene_variant 4239340 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.525C>T embC_c.525C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-525G>A embC_c.-525G>A 1 upstream_gene_variant 4239338 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-529T>C embC_c.-529T>C 1 upstream_gene_variant 4239334 1 85 0 85 86 118 9395 35587 0.00907077312519776 0.00726166861978513 0.0111903740239994 0.996695140736591 0.996043541042457 0.99726373945935 0.42156862745098 0.352940954025226 0.492509765179777 0 0 0.0424703399112491 0 0 0.0307780960741445 0 0 0.16805216982248 3.49886325530906e-09 NA NA False True 2.76064801869007 2.0640548301138 3.67990438700319 0 0 0.000392565762942224 0.996695140736591 0.996043541042457 0.99726373945935 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 79 0 79 83 107 6477 26398 0.0126524390243902 0.0100898529802971 0.0156607736681274 0.99596302584418 0.995123783435821 0.996690458006508 0.436842105263157 0.365168918360296 0.51051721399015 0 0 0.045621252758611 0 0 0.0338879994740114 0 0 0.194923910877448 4.20784634867216e-08 NA NA False True 0 1 1 0 0 0 1 3.16148730446627 2.34111678964266 4.25625058174451 0 0 0.000569373040014546 0.99596302584418 0.995123783435821 0.996690458006508 9 5) Not assoc w R UP from Uncertain to NotAwR yes 4 +Ethambutol embC c.-531C>A embC_c.-531C>A 1 upstream_gene_variant 4239332 1 0 0 0 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3817 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3154 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 1 3) Uncertain significance No change no 1 +Ethambutol embC c.-531C>T embC_c.-531C>T 1 upstream_gene_variant 4239332 0 0 0 0 7 0 9474 35705 0.000738318742748655 0.00029689231210758 0.00152062336565454 1 0.999896689850119 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 3932 4975 False False Inf 5.43056595882186 Inf 0 0 0.000389292947027732 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 7 0 6553 26505 0.0010670731707317 0.000429122972600259 0.00219733487653492 1 0.999860832946126 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 3248 4087 False False 0 0 0 0 0 0 0 Inf 5.82744514485438 Inf 0 0 0.000562771457148547 1 0.999860832946126 1 1 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-533G>T embC_c.-533G>T 1 upstream_gene_variant 4239330 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-535C>T embC_c.-535C>T 1 upstream_gene_variant 4239328 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-537C>T embC_c.-537C>T 1 upstream_gene_variant 4239326 1 3 0 3 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 0 0 0.707598226178713 0 0 0.4592581264399 0 0 9.11476410780766 1 1480 4975 False False 0 0 3.19822685561766 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethambutol embC c.-53G>A embC_c.-53G>A 1 upstream_gene_variant 4239810 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.540C>A embC_c.540C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-543G>A embC_c.-543G>A 1 upstream_gene_variant 4239320 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3777 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3116 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.546A>G embC_c.546A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.54C>T embC_c.54C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-553C>G embC_c.-553C>G 1 upstream_gene_variant 4239310 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3842 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3178 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-554G>A embC_c.-554G>A 1 upstream_gene_variant 4239309 1 4 0 4 5 8 9476 35697 0.000527370530534753 0.000171257241502832 0.00123027414547083 0.999775941744853 0.999558563909973 0.999903262744512 0.384615384615384 0.13857933889016 0.684222397085936 0 0 0.602364635616474 0 0 0.369416647552819 0 0 5.70752445443275 0.585926135220318 455 4975 False False 2.35443488813845 0.6058631448195 8.16437597956903 0 0 0.000389210799037296 0.999775941744853 0.999558563909973 0.999903262744512 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 5 8 6555 26497 0.000762195121951219 0.000247527523788107 0.00177780526826415 0.999698170156574 0.999405361976814 0.999869682578628 0.384615384615384 0.13857933889016 0.684222397085936 0 0 0.602364635616474 0 0 0.369416647552819 0 0 6.1247860414767 1 1103 4087 False False 0 0 0 0 0 0 0 2.52641113653699 0.650033651543675 8.76121355438095 0 0 0.00056259979792051 0.999698170156574 0.999405361976814 0.999869682578628 1 3) Uncertain significance No change no 1 +Ethambutol embC c.-557A>G embC_c.-557A>G 1 upstream_gene_variant 4239306 0 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3749 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3094 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.561G>A embC_c.561G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 9 12 9472 35693 0.000949266954962556 0.000434154257137837 0.00180123610483098 0.99966391261728 0.999412996653316 0.999826327071809 0.428571428571428 0.21819685688513 0.659793690719725 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.82619826858108 1.05133000370457 7.3105408075878 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 8 6 6552 26499 0.00121951219512195 0.000526641184096925 0.00240150352406598 0.99977362761743 0.99950734823901 0.999916920939814 0.571428571428571 0.288609400038307 0.823388910017882 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 5.39255189255189 1.6400519179219 18.8602578516478 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-563G>T embC_c.-563G>T 1 upstream_gene_variant 4239300 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-564C>A embC_c.-564C>A 1 upstream_gene_variant 4239299 1 3 0 3 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 9.1150193618684 1 2818.5 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-565C>T embC_c.-565C>T 1 upstream_gene_variant 4239298 1 5 0 5 538 3187 8943 32518 0.0567450690855395 0.0521721580261811 0.0615926085415441 0.910740792606077 0.90773589373929 0.913678686112479 0.144429530201342 0.133288941635398 0.156131116236927 0 0 0.521823750104981 0 0 0.00115680746183371 0 0 3.96876306769244 0.591887844648443 NA NA False True 0.613819679572269 0.557519424418688 0.674839151259331 0 0 0.000412402856939252 0.910740792606077 0.90773589373929 0.913678686112479 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 3 0 3 332 2287 6228 24218 0.0506097560975609 0.0454299306235829 0.0561935393523114 0.913714393510658 0.910269671684708 0.917068099125064 0.12676594119893 0.114255250617786 0.140117367829323 0 0 0.707598226178713 0 0 0.00161167731233838 0 0 9.4136171491673 1 NA NA False True 0 1 1 0 0 1 1 0.564496937396285 0.499953115880894 0.635856957550235 0 0 0.000592130250119256 0.913714393510658 0.910269671684708 0.917068099125064 232 Not assoc w R 5) Not assoc w R No change yes 1 +Ethambutol embC c.-568T>C embC_c.-568T>C 1 upstream_gene_variant 4239295 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-568T>G embC_c.-568T>G 1 upstream_gene_variant 4239295 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-56G>A embC_c.-56G>A 1 upstream_gene_variant 4239807 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-570G>A embC_c.-570G>A 1 upstream_gene_variant 4239293 2 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 0 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 157.21479794295 1 1103 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-572G>A embC_c.-572G>A 1 upstream_gene_variant 4239291 1 11 0 11 0 13 9481 35692 0 0 0.00038900558066021 0.999635905335387 0.999377467513205 0.999806121137399 0 0 0.24705263800047 0 0 0.284914152918154 0 0 0.24705263800047 0 0 1.50026285994737 0.135455083434985 155 4975 False False 0 0 1.2354962611609 0 0 0.00038900558066021 0.999635905335387 0.999377467513205 0.999806121137399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 0 11 6560 26494 0 0 0.000562171107654053 0.999584983965289 0.999257543293353 0.999792807866341 0 0 0.284914152918154 0 0 0.336267116879942 0 0 0.284914152918154 0 0 2.0467564802507 0.220128896238822 160 4087 False False 0 0 0 0 0 0 0 0 0 1.60965686204705 0 0 0.000562171107654053 0.999584983965289 0.999257543293353 0.999792807866341 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-575A>C embC_c.-575A>C 1 upstream_gene_variant 4239288 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4048 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3349 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-581G>T embC_c.-581G>T 1 upstream_gene_variant 4239282 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-585G>C embC_c.-585G>C 1 upstream_gene_variant 4239278 1 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 157.21479794295 1 1103 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-587_-586insTGGCCGCCGCCATCGGGT embC_c.-587_-586insTGGCCGCCGCCATCGGGT 1 upstream_gene_variant 4239276 1 5 0 5 0 11 9481 35694 0 0 0.00038900558066021 0.999691919899173 0.999448826618347 0.999846197812 0 0 0.284914152918154 0 0 0.521823750104981 0 0 0.284914152918154 0 0 4.10913762394584 0.590983945755588 525 4975 False False 0 0 1.50034693324555 0 0 0.00038900558066021 0.999691919899173 0.999448826618347 0.999846197812 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 10 6560 26495 0 0 0.000562171107654053 0.999622712695717 0.999306265033238 0.999819061720012 0 0 0.30849710781876 0 0 0.521823750104981 0 0 0.30849710781876 0 0 4.40859972596443 0.590384738162151 252 4087 False False 0 0 0 0 0 0 0 0 0 1.80248078294835 0 0 0.000562171107654053 0.999622712695717 0.999306265033238 0.999819061720012 12 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-589C>G embC_c.-589C>G 1 upstream_gene_variant 4239274 0 0 0 0 19 112 9462 35593 0.00200400801603206 0.00120696150945356 0.00312774546302964 0.996863184427951 0.996226799682733 0.997416475853179 0.145038167938931 0.0896382806199294 0.217194651578182 NA NA NA 0 0 0.0323999259313598 NA NA NA NA NA NA False True 0.638141853126792 0.370204963260816 1.04440013016715 0 0 0.000389786564106482 0.996863184427951 0.996226799682733 0.997416475853179 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 11 88 6549 26417 0.00167682926829268 0.000837354988859942 0.00299832542833478 0.996679871722316 0.995911085545019 0.99733633426481 0.111111111111111 0.056788614961314 0.190116434819387 NA NA NA 0 0 0.041052629058078 NA NA NA NA NA NA False True 0 1 1 0 0 1 0 0.504218201252099 0.242732526225438 0.947618057264388 0 0 0.000563115090054247 0.996679871722316 0.995911085545019 0.99733633426481 15 Not assoc w R 5) Not assoc w R No change yes 1 +Ethambutol embC c.-591T>G embC_c.-591T>G 1 upstream_gene_variant 4239272 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.594C>A embC_c.594C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-595T>C embC_c.-595T>C 1 upstream_gene_variant 4239268 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-601G>A embC_c.-601G>A 1 upstream_gene_variant 4239262 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-605G>C embC_c.-605G>C 1 upstream_gene_variant 4239258 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-606G>C embC_c.-606G>C 1 upstream_gene_variant 4239257 1 7 0 7 0 7 9481 35698 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 2.61285174975179 0.357638874560194 311 4975 False False 0 0 2.61285174975179 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12104088004766 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-60C>T embC_c.-60C>T 1 upstream_gene_variant 4239803 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.612G>A embC_c.612G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.10982832991351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.615C>T embC_c.615C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.10982832991351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.40943166615857 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-621A>C embC_c.-621A>C 1 upstream_gene_variant 4239242 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-626G>T embC_c.-626G>T 1 upstream_gene_variant 4239237 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-627G>A embC_c.-627G>A 1 upstream_gene_variant 4239236 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-628C>G embC_c.-628C>G 1 upstream_gene_variant 4239235 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-628C>T embC_c.-628C>T 1 upstream_gene_variant 4239235 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12104088004766 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 3 3) Uncertain significance No change no 1 +Ethambutol embC c.-632G>A embC_c.-632G>A 1 upstream_gene_variant 4239231 1 1 1 0 26 8 9455 35697 0.00274232675878071 0.00179213692288159 0.00401558030584103 0.999775941744853 0.999558563909973 0.999903262744512 0.764705882352941 0.588292158092833 0.892538184224992 1 0.025 1 0.111111111111111 0.00280913674659921 0.482496514917337 Inf 0.0967964164612706 Inf 0.209421300910238 163 4975 False False 12.2702538339502 5.39158916083833 31.3653074731252 0.00010575296108291 2.67742957814623e-06 0.000589075373387821 0.999775941744853 0.999558563909973 0.999903262744512 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3179 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 2 3) Uncertain significance No change no 1 +Ethambutol embC c.-633C>T embC_c.-633C>T 1 upstream_gene_variant 4239230 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3913 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3231 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-635G>A embC_c.-635G>A 1 upstream_gene_variant 4239228 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-646C>G embC_c.-646C>G 1 upstream_gene_variant 4239217 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3843 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3180 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-651C>G embC_c.-651C>G 1 upstream_gene_variant 4239212 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-659G>C embC_c.-659G>C 1 upstream_gene_variant 4239204 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4029 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3330 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-662C>A embC_c.-662C>A 1 upstream_gene_variant 4239201 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-666G>A embC_c.-666G>A 1 upstream_gene_variant 4239197 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.669C>T embC_c.669C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-66G>A embC_c.-66G>A 1 upstream_gene_variant 4239797 1 1 0 1 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.975 0 0 0.521823750104981 0 0 146.521788926551 1 1480 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 157.173142990263 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 1 3) Uncertain significance No change no 1 +Ethambutol embC c.-675G>C embC_c.-675G>C 1 upstream_gene_variant 4239188 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3799 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3135 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-679C>A embC_c.-679C>A 1 upstream_gene_variant 4239184 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.681G>A embC_c.681G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.684G>A embC_c.684G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.707313928675496 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-6C>G embC_c.-6C>G 1 upstream_gene_variant 4239857 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-705C>T embC_c.-705C>T 1 upstream_gene_variant 4239158 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.708C>T embC_c.708C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-708C>T embC_c.-708C>T 1 upstream_gene_variant 4239155 1 4 0 4 1 4 9480 35701 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999887970872426 0.999713186009257 0.999969475016731 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.705755198674 0.585905489084247 449.5 4975 False False 0.941482067510548 0.0191153149568561 9.51304376083015 0 0 0.00038904660702099 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.5214194708504 1 2276.5 4087 False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 0 0 0.000562256793434776 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-713G>A embC_c.-713G>A 1 upstream_gene_variant 4239150 1 1 0 1 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 146.529978407112 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 157.179059039538 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 1 3) Uncertain significance No change no 1 +Ethambutol embC c.-717A>G embC_c.-717A>G 1 upstream_gene_variant 4239146 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-722G>A embC_c.-722G>A 1 upstream_gene_variant 4239141 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.723C>T embC_c.723C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-723G>A embC_c.-723G>A 1 upstream_gene_variant 4239140 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-732G>T embC_c.-732G>T 1 upstream_gene_variant 4239131 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3757 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3099 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-735G>A embC_c.-735G>A 1 upstream_gene_variant 4239128 1 1 1 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.096562813829025 Inf 0.209821626167397 198.5 4975 False False Inf 0.096562813829025 Inf 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-737C>T embC_c.-737C>T 1 upstream_gene_variant 4239126 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-739C>G embC_c.-739C>G 1 upstream_gene_variant 4239124 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-741G>C embC_c.-741G>C 1 upstream_gene_variant 4239122 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.744G>C embC_c.744G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-746C>T embC_c.-746C>T 1 upstream_gene_variant 4239117 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3788 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3125 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-747C>T embC_c.-747C>T 1 upstream_gene_variant 4239116 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3951 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3265 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-751T>C embC_c.-751T>C 1 upstream_gene_variant 4239112 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3750 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-753C>T embC_c.-753C>T 1 upstream_gene_variant 4239110 1 0 0 0 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3971 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3285 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 4 3) Uncertain significance No change no 1 +Ethambutol embC c.756C>T embC_c.756C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-756G>A embC_c.-756G>A 1 upstream_gene_variant 4239107 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-75C>T embC_c.-75C>T 1 upstream_gene_variant 4239788 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3844 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-762C>G embC_c.-762C>G 1 upstream_gene_variant 4239101 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3868 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3200 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-763G>T embC_c.-763G>T 1 upstream_gene_variant 4239100 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-765C>A embC_c.-765C>A 1 upstream_gene_variant 4239098 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.768C>T embC_c.768C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-770G>A embC_c.-770G>A 1 upstream_gene_variant 4239093 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-770G>C embC_c.-770G>C 1 upstream_gene_variant 4239093 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-771G>A embC_c.-771G>A 1 upstream_gene_variant 4239092 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3751 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3095 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-773C>T embC_c.-773C>T 1 upstream_gene_variant 4239090 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-776G>A embC_c.-776G>A 1 upstream_gene_variant 4239087 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-776G>C embC_c.-776G>C 1 upstream_gene_variant 4239087 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-778G>A embC_c.-778G>A 1 upstream_gene_variant 4239085 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3805 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3142 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-782G>A embC_c.-782G>A 1 upstream_gene_variant 4239081 1 2 0 2 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.058895521352 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-783A>G embC_c.-783A>G 1 upstream_gene_variant 4239080 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-785C>T embC_c.-785C>T 1 upstream_gene_variant 4239078 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4010 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3317 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-786G>C embC_c.-786G>C 1 upstream_gene_variant 4239077 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4062 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3359 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-792A>G embC_c.-792A>G 1 upstream_gene_variant 4239071 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.792C>G embC_c.792C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-799C>T embC_c.-799C>T 1 upstream_gene_variant 4239064 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-805T>C embC_c.-805T>C 1 upstream_gene_variant 4239058 0 0 0 0 2 8 9479 35697 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999775941744853 0.999558563909973 0.999903262744512 0.2 0.0252107263268333 0.556095462307641 NA NA NA 0 0 0.369416647552819 NA NA NA NA 3972 4975 False False 0.941475894081654 0.0973783182815292 4.71874266187613 0 0 0.000389087642036349 0.999775941744853 0.999558563909973 0.999903262744512 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 8 6558 26497 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999698170156574 0.999405361976814 0.999869682578628 0.2 0.0252107263268333 0.556095462307641 NA NA NA 0 0 0.369416647552819 NA NA NA NA 3286 4087 False False 0 0 0 0 0 0 0 1.01010216529429 0.104463368269269 5.06308595441747 0 0 0.00056234250533983 0.999698170156574 0.999405361976814 0.999869682578628 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-808T>C embC_c.-808T>C 1 upstream_gene_variant 4239055 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-810G>A embC_c.-810G>A 1 upstream_gene_variant 4239053 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3758 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3100 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-812C>T embC_c.-812C>T 1 upstream_gene_variant 4239051 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4016 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3320 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-815T>C embC_c.-815T>C 1 upstream_gene_variant 4239048 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-816G>T embC_c.-816G>T 1 upstream_gene_variant 4239047 1 2 1 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 3.76624472573839 0.0479745002090283 294.932792118969 0.375621806809355 335.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 4.04085988717792 0.0514701624188962 316.380494544091 0.35743759524028 195 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.817C>T embC_c.817C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-817T>G embC_c.-817T>G 1 upstream_gene_variant 4239046 1 3 0 3 1 3 9480 35702 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99991597815432 0.999754472342108 0.99998267234027 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11649128277037 1 2818.5 4975 False False 1.25534458509142 0.0239099774609589 15.6346568618898 0 0 0.00038904660702099 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-819G>T embC_c.-819G>T 1 upstream_gene_variant 4239044 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3752 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3096 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-81C>G embC_c.-81C>G 1 upstream_gene_variant 4239782 1 1 1 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.096562813829025 Inf 0.209821626167397 198.5 4975 False False Inf 0.096562813829025 Inf 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-824G>A embC_c.-824G>A 1 upstream_gene_variant 4239039 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3980 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3293 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-826T>C embC_c.-826T>C 1 upstream_gene_variant 4239037 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3973 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3287 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-828G>A embC_c.-828G>A 1 upstream_gene_variant 4239035 1 1 1 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.096562813829025 Inf 0.209821626167397 198.5 4975 False False Inf 0.096562813829025 Inf 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.103599830448027 Inf 0.198397096627854 142 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-82C>T embC_c.-82C>T 1 upstream_gene_variant 4239781 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3921 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3239 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-831T>C embC_c.-831T>C 1 upstream_gene_variant 4239032 1 0 0 0 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4017 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3321 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 4 3) Uncertain significance No change no 1 +Ethambutol embC c.-832G>A embC_c.-832G>A 1 upstream_gene_variant 4239031 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3778 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3117 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-832G>C embC_c.-832G>C 1 upstream_gene_variant 4239031 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3998 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3308 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.834C>T embC_c.834C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.837C>G embC_c.837C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 4 4 9477 35701 0.000421896424427802 0.000114964157806894 0.00107986688593449 0.999887970872426 0.999713186009257 0.999969475016731 0.5 0.157012770487058 0.842987229512941 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.76712039675002 0.701511118396156 20.2258787305262 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 4 4 6556 26501 0.000609756097560975 0.000166162208307701 0.00156047520083291 0.999849085078287 0.999613643356053 0.999958879281354 0.5 0.157012770487058 0.842987229512941 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.04225137278828 0.752648440329067 21.7051291323528 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-83G>A embC_c.-83G>A 1 upstream_gene_variant 4239780 1 2 0 2 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.058895521352 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance No change no 1 +Ethambutol embC c.-841G>A embC_c.-841G>A 1 upstream_gene_variant 4239022 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-846G>A embC_c.-846G>A 1 upstream_gene_variant 4239017 1 4 0 4 1 7 9480 35698 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999803949026747 0.999596102051779 0.999921173824063 0.125 0.0031597235312519 0.526509670875206 0 0 0.602364635616474 0 0 0.409616397225003 0 0 5.70527575258439 0.585899894917367 440 4975 False False 0.53794454490657 0.0119383062528594 4.18812953339448 0 0 0.00038904660702099 0.999803949026747 0.999596102051779 0.999921173824063 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 1 7 6559 26498 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999735898887002 0.999455926960675 0.999893811273379 0.125 0.0031597235312519 0.526509670875206 0 0 0.602364635616474 0 0 0.409616397225003 0 0 6.12128126284296 1 2276.5 4087 False False 0 0 0 0 0 0 0 0.577135016226341 0.0128071434235918 4.49361310760002 0 0 0.000562256793434776 0.999735898887002 0.999455926960675 0.999893811273379 1 3) Uncertain significance No change no 1 +Ethambutol embC c.-856A>C embC_c.-856A>C 1 upstream_gene_variant 4239007 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-85C>T embC_c.-85C>T 1 upstream_gene_variant 4239778 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4018 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3322 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-864C>G embC_c.-864C>G 1 upstream_gene_variant 4238999 0 0 0 0 3 1 9478 35704 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999971992718106 0.999843963402622 0.999999290917266 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 3779 4975 False False 11.3011183794049 0.90722384791697 591.183089908516 0 0 0.000389128685709026 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 1 6557 26504 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 0.999962271269571 0.999789807096406 0.999999044791703 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 3118 4087 False False 0 0 0 0 0 0 0 12.1262772609425 0.973374031902014 634.171386087929 0 0 0.000562428243381166 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.864G>C embC_c.864G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.867C>T embC_c.867C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-867C>T embC_c.-867C>T 1 upstream_gene_variant 4238996 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.873C>A embC_c.873C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-878G>A embC_c.-878G>A 1 upstream_gene_variant 4238985 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.87C>A embC_c.87C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.87C>T embC_c.87C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-881G>A embC_c.-881G>A 1 upstream_gene_variant 4238982 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.885C>G embC_c.885C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.885C>T embC_c.885C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.76624472573839 0.0479745002090283 294.932792118969 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-886A>C embC_c.-886A>C 1 upstream_gene_variant 4238977 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3818 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3155 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.888C>T embC_c.888C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 7 107 9474 35598 0.000738318742748655 0.00029689231210758 0.00152062336565454 0.997003220837417 0.99637983051578 0.997543436813858 0.0614035087719298 0.0250413196747636 0.122426916219742 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.245813924582576 0.096472723339455 0.524441836569905 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 5 88 6555 26417 0.000762195121951219 0.000247527523788107 0.00177780526826415 0.996679871722316 0.995911085545019 0.99733633426481 0.053763440860215 0.0176849998060786 0.121019983114096 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 1 0.228980306497468 0.072525157260464 0.555212348949553 NA NA NA NA NA NA 18 5) Not assoc w R Now listed Silent mutation no 0 +Ethambutol embC c.-88G>A embC_c.-88G>A 1 upstream_gene_variant 4239775 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3819 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3156 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-891C>G embC_c.-891C>G 1 upstream_gene_variant 4238972 1 14 0 14 1 18 9480 35687 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99949586892592 0.999203372130377 0.999701193476901 0.0526315789473684 0.00133162880417942 0.260280654195214 0 0 0.231635761650116 0 0 0.185301968137852 0 0 1.13510311395767 0.0520836277256202 94 4975 False False 0.20913619315518 0.00502263873391001 1.32494056057363 0 0 0.00038904660702099 0.99949586892592 0.999203372130377 0.999701193476901 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 1 14 6559 26491 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999471797774004 0.999113925067086 0.999711197799087 0.0666666666666666 0.0016864302413527 0.319484566578303 0 0 0.30849710781876 0 0 0.231635761650116 0 0 1.80248350668166 0.227543297284438 176 4087 False False 0 0 0 0 0 0 0 0.288491276980375 0.0068252589969484 1.89684270073588 0 0 0.000562256793434776 0.999471797774004 0.999113925067086 0.999711197799087 4 3) Uncertain significance No change no 1 +Ethambutol embC c.891C>T embC_c.891C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-893C>A embC_c.-893C>A 1 upstream_gene_variant 4238970 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-896C>T embC_c.-896C>T 1 upstream_gene_variant 4238967 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-900C>T embC_c.-900C>T 1 upstream_gene_variant 4238963 1 897 12 885 186 1392 9295 34313 0.0196181837358928 0.0169222228068993 0.022614667406382 0.961013863604537 0.958954286901131 0.962998013056843 0.11787072243346 0.102366248646004 0.134812273464995 0.0133779264214046 0.00693116099488139 0.0232518383819869 0.00854700854700854 0.00442393802783651 0.0148822628325155 0.0500549776169072 0.0257689684974834 0.0879336163054506 4.81305759349644e-73 NA NA False True 0.493268071451095 0.420238011081577 0.576263817682147 0.00128935210056946 0.000666398912155448 0.00225115434203793 0.961013863604537 0.958954286901131 0.962998013056843 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 601 7 594 132 945 6428 25560 0.0201219512195121 0.0168624141873629 0.0238172789066501 0.964346349745331 0.96204367673513 0.966546484455737 0.122562674094707 0.103565273390823 0.143648822752612 0.0116472545757071 0.00469527090009238 0.0238498192900389 0.00735294117647058 0.00296122491793458 0.0150908623657143 0.0468593841338085 0.018776768876274 0.0972296890942286 5.29954006816291e-47 NA NA False True 0 1 1 0 0 1 1 0.555427149079918 0.458441516121418 0.668504132704854 0.00108780108780108 0.000437460759298603 0.00223999352468474 0.964346349745331 0.96204367673513 0.966546484455737 172 Not assoc w R 5) Not assoc w R No change yes 1 +Ethambutol embC c.-903G>A embC_c.-903G>A 1 upstream_gene_variant 4238960 1 6 0 6 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.19822685561766 0.354697857676227 290 4975 False False 0 0 3.19822685561766 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.906G>A embC_c.906G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 3 9480 35702 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99991597815432 0.999754472342108 0.99998267234027 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.25534458509142 0.0239099774609589 15.6346568618898 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-910G>A embC_c.-910G>A 1 upstream_gene_variant 4238953 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3780 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3119 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-914G>A embC_c.-914G>A 1 upstream_gene_variant 4238949 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3952 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3266 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.915G>A embC_c.915G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-916C>T embC_c.-916C>T 1 upstream_gene_variant 4238947 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-920G>A embC_c.-920G>A 1 upstream_gene_variant 4238943 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.921G>T embC_c.921G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-925T>C embC_c.-925T>C 1 upstream_gene_variant 4238938 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-927G>T embC_c.-927G>T 1 upstream_gene_variant 4238936 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-928C>A embC_c.-928C>A 1 upstream_gene_variant 4238935 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3902 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-92C>T embC_c.-92C>T 1 upstream_gene_variant 4239771 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-930C>T embC_c.-930C>T 1 upstream_gene_variant 4238933 0 0 0 0 2 1 9479 35704 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999971992718106 0.999843963402622 0.999999290917266 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 4043 4975 False False 7.53328410169849 0.392120325718966 443.147628387906 0 0 0.000389087642036349 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 1 6558 26504 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999962271269571 0.999789807096406 0.999999044791703 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 3344 4087 False False 0 0 0 0 0 0 0 8.08295211954864 0.420719628662148 475.373667785977 0 0 0.00056234250533983 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-932G>A embC_c.-932G>A 1 upstream_gene_variant 4238931 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-934G>A embC_c.-934G>A 1 upstream_gene_variant 4238929 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-938G>A embC_c.-938G>A 1 upstream_gene_variant 4238925 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-941G>A embC_c.-941G>A 1 upstream_gene_variant 4238922 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3999 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3309 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 2 3) Uncertain significance No change no 1 +Ethambutol embC c.942C>T embC_c.942C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.945C>G embC_c.945C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.945C>T embC_c.945C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-950C>T embC_c.-950C>T 1 upstream_gene_variant 4238913 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-957G>T embC_c.-957G>T 1 upstream_gene_variant 4238906 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.960C>T embC_c.960C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.88306962025316 0.0319145727646777 36.1783621216076 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-963C>G embC_c.-963C>G 1 upstream_gene_variant 4238900 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3753 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3097 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.-964C>T embC_c.-964C>T 1 upstream_gene_variant 4238899 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-965A>G embC_c.-965A>G 1 upstream_gene_variant 4238898 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.966G>T embC_c.966G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-968A>G embC_c.-968A>G 1 upstream_gene_variant 4238895 1 3 0 3 3 5 9478 35700 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999859963590533 0.999673232250017 0.999954529045718 0.375 0.0852334141372535 0.755136783633448 0 0 0.707598226178713 0 0 0.521823750104981 0 0 9.11790404714036 1 2818.5 4975 False False 2.25997045790251 0.350887762500293 11.6204549580208 0 0 0.000389128685709026 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 2 5 6558 26500 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999811356347858 0.999559824020536 0.9999387451734 0.285714285714285 0.0366925661760855 0.709579136262657 0 0 0.707598226178713 0 0 0.521823750104981 0 0 9.78208365030682 1 2276.5 4087 False False 0 0 0 0 0 0 0 1.61634644708752 0.15386320830351 9.87586276350829 0 0 0.00056234250533983 0.999811356347858 0.999559824020536 0.9999387451734 2 3) Uncertain significance No change no 1 +Ethambutol embC c.96C>T embC_c.96C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-96G>A embC_c.-96G>A 1 upstream_gene_variant 4239767 1 11 0 11 0 12 9481 35693 0 0 0.00038900558066021 0.99966391261728 0.999412996653316 0.999826327071809 0 0 0.264648469397051 0 0 0.284914152918154 0 0 0.264648469397051 0 0 1.50030489649552 0.135454869906327 152.5 4975 False False 0 0 1.35519147325258 0 0 0.00038900558066021 0.99966391261728 0.999412996653316 0.999826327071809 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 0 11 0 12 6560 26493 0 0 0.000562171107654053 0.999547255234861 0.999209279704825 0.999766038988972 0 0 0.264648469397051 0 0 0.284914152918154 0 0 0.264648469397051 0 0 1.60959611461803 0.136617078895873 102.5 4087 False False 0 0 0 0 0 0 0 0 0 1.45386850159099 0 0 0.000562171107654053 0.999547255234861 0.999209279704825 0.999766038988972 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-978C>G embC_c.-978C>G 1 upstream_gene_variant 4238885 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-979C>T embC_c.-979C>T 1 upstream_gene_variant 4238884 1 8 0 8 1 9 9480 35696 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99974793446296 0.999521555266748 0.999884733314884 0.1 0.00252857854446178 0.445016117028195 0 0 0.369416647552819 0 0 0.336267116879942 0 0 2.20641221596959 0.217687831472876 233 4975 False False 0.418377871542428 0.00954775074807024 3.01988679231401 0 0 0.00038904660702099 0.99974793446296 0.999521555266748 0.999884733314884 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 1 8 6559 26497 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999698170156574 0.999405361976814 0.999869682578628 0.111111111111111 0.00280913674659921 0.482496514917337 0 0 0.369416647552819 0 0 0.369416647552819 0 0 2.36731479326647 0.369975844634229 221.5 4087 False False 0 0 0 0 0 0 0 0.504974081414849 0.0113820510464553 3.76768363928727 0 0 0.000562256793434776 0.999698170156574 0.999405361976814 0.999869682578628 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-980G>A embC_c.-980G>A 1 upstream_gene_variant 4238883 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-983G>C embC_c.-983G>C 1 upstream_gene_variant 4238880 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3845 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3181 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.984C>T embC_c.984C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-984G>A embC_c.-984G>A 1 upstream_gene_variant 4238879 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.-989A>C embC_c.-989A>C 1 upstream_gene_variant 4238874 1 26 1 25 1 33 9480 35672 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999075759697521 0.998702265560311 0.99936371276009 0.0294117647058823 0.00074436423469026 0.153267669560317 0.0384615384615384 0.00097328789333503 0.196369646762539 0.0294117647058823 0.00074436423469026 0.153267669560317 0.150514767932489 0.00366929284757586 0.919756758966192 0.0286934397830882 71 4975 False False 0.114026339342795 0.00280660017027685 0.681323181724885 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999075759697521 0.998702265560311 0.99936371276009 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 21 1 20 1 27 6559 26478 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.998981324278438 0.998518223777074 0.999328582311798 0.0357142857142857 0.000903798755658059 0.183477597544623 0.0476190476190476 0.00120488344836351 0.238159909936821 0.0357142857142857 0.000903798755658059 0.183477597544623 0.20184479341363 0.00487273647013018 1.26247825759155 0.100747163113187 97 4087 False False 0 0 0 0 0 0 0 0.149514661787874 0.00365502754263224 0.907506304262874 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.998981324278438 0.998518223777074 0.999328582311798 3 3) Uncertain significance No change no 1 +Ethambutol embC c.-98G>A embC_c.-98G>A 1 upstream_gene_variant 4239765 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC c.990G>C embC_c.990G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 1 9479 35704 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999971992718106 0.999843963402622 0.999999290917266 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 7.53328410169849 0.392120325718966 443.147628387906 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 2 1 6558 26504 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999962271269571 0.999789807096406 0.999999044791703 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 8.08295211954864 0.420719628662148 475.373667785977 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.991C>T embC_c.991C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-995G>A embC_c.-995G>A 1 upstream_gene_variant 4238868 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC c.999G>A embC_c.999G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 1 9479 35704 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999971992718106 0.999843963402622 0.999999290917266 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 7.53328410169849 0.392120325718966 443.147628387906 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embC c.-99G>C embC_c.-99G>C 1 upstream_gene_variant 4239764 1 0 0 0 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4011 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3318 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 4 3) Uncertain significance No change no 1 +Ethambutol embC c.-9G>T embC_c.-9G>T 1 upstream_gene_variant 4239854 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3846 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3182 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala1046Ser embC_p.Ala1046Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3974 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3288 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala1046Thr embC_p.Ala1046Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Ala1059Thr embC_p.Ala1059Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala1059Val embC_p.Ala1059Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 0.5 0.012579117093425 0.987420882906574 0.333333333333333 0.00840375865961264 0.905700675949754 3.76613924050632 0.0479731565330282 294.924553356571 0.375629145492829 341.5 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.103595921751575 Inf 0.198403097023953 155.5 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala1073Thr embC_p.Ala1073Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3735 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3083 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala116Thr embC_p.Ala116Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala11Thr embC_p.Ala11Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala142Thr embC_p.Ala142Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3847 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3183 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala165Thr embC_p.Ala165Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4044 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3345 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala205Ser embC_p.Ala205Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala232Val embC_p.Ala232Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3831 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3167 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala233Thr embC_p.Ala233Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 9480 35702 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99991597815432 0.999754472342108 0.99998267234027 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11649128277037 1 2818.5 4975 False False 1.25534458509142 0.0239099774609589 15.6346568618898 0 0 0.00038904660702099 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 3 6559 26502 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999886813808715 0.999669257903365 0.999976657677988 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.78133043653875 1 2276.5 4087 False False 0 0 0 0 0 0 0 1.34685165421558 0.025651688752077 16.7753654027497 0 0 0.000562256793434776 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala243Thr embC_p.Ala243Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala247Ser embC_p.Ala247Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4019 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3323 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala24Val embC_p.Ala24Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala279Thr embC_p.Ala279Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.058895521352 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala279Val embC_p.Ala279Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala307Ser embC_p.Ala307Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala307Thr embC_p.Ala307Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala311Ser embC_p.Ala311Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala340Thr embC_p.Ala340Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala370Thr embC_p.Ala370Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Ala377Thr embC_p.Ala377Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala378Thr embC_p.Ala378Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala387Val embC_p.Ala387Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 334 61 9147 35644 0.0352283514397215 0.0316081040425098 0.0391376290397098 0.998291555804509 0.997805965507392 0.998692931300774 0.845569620253164 0.80609359702328 0.879767397977971 NA NA NA 0 0 0.0586812239322925 NA NA NA NA 3922 4975 False False 21.3365593305697 16.1739932211076 28.5445386899296 0 0 0.000403207140358479 0.998291555804509 0.997805965507392 0.998692931300774 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 99 14 6461 26491 0.0150914634146341 0.0122820711467651 0.0183430880851781 0.999471797774004 0.999113925067086 0.999711197799087 0.876106194690265 0.800870455307208 0.930581328143429 NA NA NA 0 0 0.231635761650116 NA NA NA NA 3240 4087 False False 0 0 0 0 0 0 0 28.9938421739226 16.4822910879948 54.9696477150394 0 0 0.00057078263113668 0.999471797774004 0.999113925067086 0.999711197799087 439 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala416Ser embC_p.Ala416Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Ala418Pro embC_p.Ala418Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala418Ser embC_p.Ala418Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3933 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3249 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Ala41Ser embC_p.Ala41Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3981 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Ala426Glu embC_p.Ala426Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala426Pro embC_p.Ala426Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala448Val embC_p.Ala448Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 8 9481 35697 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 0 0 0.369416647552819 0 0 0.409616397225003 0 0 0.369416647552819 0 0 2.61277856511022 0.357639330631355 317 4975 False False 0 0 2.20624116275339 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.40943166615857 0.590385352956204 278 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala46Val embC_p.Ala46Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3806 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3143 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala480Thr embC_p.Ala480Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Ala480Val embC_p.Ala480Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4020 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala484Thr embC_p.Ala484Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala505Gly embC_p.Ala505Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Ala505Thr embC_p.Ala505Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 1.88306962025316 0.0319145727646777 36.1783621216076 0.506635653517051 355 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.103599830448027 Inf 0.198397096627854 142 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala525Thr embC_p.Ala525Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala536Val embC_p.Ala536Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Ala539Val embC_p.Ala539Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3858 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3190 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala543Thr embC_p.Ala543Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 9.1150193618684 1 2818.5 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 9.77910191708565 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala545Thr embC_p.Ala545Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala561Val embC_p.Ala561Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala562Pro embC_p.Ala562Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3800 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3136 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala578Ser embC_p.Ala578Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Ala578Val embC_p.Ala578Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3764 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3106 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala57Thr embC_p.Ala57Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 146.529978407112 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala57Val embC_p.Ala57Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala597Pro embC_p.Ala597Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala604Gly embC_p.Ala604Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala605Ser embC_p.Ala605Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3807 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3144 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Ala607Pro embC_p.Ala607Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala611Thr embC_p.Ala611Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala612Thr embC_p.Ala612Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3808 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3145 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Ala612Val embC_p.Ala612Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala623Thr embC_p.Ala623Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3809 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3146 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala624Thr embC_p.Ala624Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.10982832991351 0.590980565810755 492 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.40943166615857 0.590385352956204 278 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Ala631Ser embC_p.Ala631Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala664Glu embC_p.Ala664Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala664Thr embC_p.Ala664Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 3 9480 35702 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99991597815432 0.999754472342108 0.99998267234027 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.0610057960224 1 2818.5 4975 False False 1.25534458509142 0.0239099774609589 15.6346568618898 0 0 0.00038904660702099 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 3 6559 26502 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999886813808715 0.999669257903365 0.999976657677988 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 21.5206089807014 1 2276.5 4087 False False 0 0 0 0 0 0 0 1.34685165421558 0.025651688752077 16.7753654027497 0 0 0.000562256793434776 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala676Thr embC_p.Ala676Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala68Pro embC_p.Ala68Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4000 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Ala68Thr embC_p.Ala68Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.096562813829025 Inf 0.209821626167397 198.5 4975 False False Inf 0.096562813829025 Inf 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Ala6Ser embC_p.Ala6Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Ala6Thr embC_p.Ala6Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala701Gly embC_p.Ala701Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala701Thr embC_p.Ala701Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Ala711Thr embC_p.Ala711Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 7 9481 35698 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 2.61285174975179 0.357638874560194 311 4975 False False 0 0 2.61285174975179 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 2 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala726Gly embC_p.Ala726Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 1 9478 35704 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999971992718106 0.999843963402622 0.999999290917266 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 3848 4975 False False 11.3011183794049 0.90722384791697 591.183089908516 0 0 0.000389128685709026 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3184 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 10 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala726Ser embC_p.Ala726Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3953 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3267 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala733Thr embC_p.Ala733Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 20.058335224773 1 1480 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala745Thr embC_p.Ala745Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3754 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala767Glu embC_p.Ala767Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Ala771Thr embC_p.Ala771Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Ala774Asp embC_p.Ala774Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.096562813829025 Inf 0.209821626167397 198.5 4975 False False Inf 0.096562813829025 Inf 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.103599830448027 Inf 0.198397096627854 142 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Ala774Ser embC_p.Ala774Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 388 42 346 353 461 9128 35244 0.0372323594557536 0.0335113633016309 0.0412410019249889 0.987088643047192 0.985863204189463 0.988233871904001 0.433660933660933 0.399295309864539 0.468508640375058 0.108247422680412 0.079136590451621 0.143494508684992 0.0834990059642147 0.0608399058071994 0.111191376964871 0.468686832866413 0.331536778317647 0.647487749148562 5.05385345273808e-07 18 4975 True True 2.95653715487232 2.56144245278284 3.41011931407317 0.00458015267175572 0.00330290551774591 0.00618604655356871 0.987088643047192 0.985863204189463 0.988233871904001 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 112 2 110 65 141 6495 26364 0.00990853658536585 0.00765528934896244 0.0126120375024785 0.99468024900962 0.993729163387056 0.995520254957775 0.315533980582524 0.25272006909265 0.383750005013822 0.0178571428571428 0.00216994638493558 0.0630189471879673 0.0139860139860139 0.00169828182787868 0.0496077097254143 0.0738022254881377 0.00881741560466157 0.273174995018037 1.41054127833458e-08 13 4087 True True 0 1 1 0 0 0 0 1.87122663914959 1.37092910838946 2.53121021868319 0.000307834385100815 3.72823465290621e-05 0.00111155661311799 0.99468024900962 0.993729163387056 0.995520254957775 72 Not assoc w R 5) Not assoc w R No change yes 1 +Ethambutol embC p.Ala792Thr embC_p.Ala792Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala79Thr embC_p.Ala79Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala828Thr embC_p.Ala828Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala856Ser embC_p.Ala856Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Ala856Thr embC_p.Ala856Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala862Thr embC_p.Ala862Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 9.1150193618684 1 2818.5 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.77947080093164 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala887Thr embC_p.Ala887Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Ala887Val embC_p.Ala887Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Ala888Gly embC_p.Ala888Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3736 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala901Ser embC_p.Ala901Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3890 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala907Thr embC_p.Ala907Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala91Thr embC_p.Ala91Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4055 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3355 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Ala925Gly embC_p.Ala925Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala925Thr embC_p.Ala925Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala925Val embC_p.Ala925Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 4 9478 35701 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999887970872426 0.999713186009257 0.999969475016731 0.428571428571428 0.0989882784425078 0.815948432359917 0 0 0.975 0 0 0.602364635616474 0 0 146.572156186053 1 1480 4975 False False 2.82504220299641 0.41374306608866 16.6996717858556 0 0 0.000389128685709026 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 4 6557 26501 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 0.999849085078287 0.999613643356053 0.999958879281354 0.428571428571428 0.0989882784425078 0.815948432359917 0 0 0.975 0 0 0.602364635616474 0 0 157.244877156611 1 2276.5 4087 False False 0 0 0 0 0 0 0 3.0312261705048 0.443920296646785 17.9196364560967 0 0 0.000562428243381166 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala92Gly embC_p.Ala92Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala931Thr embC_p.Ala931Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 6 7 9475 35698 0.000632844636641704 0.000232277107744303 0.00137692358870305 0.999803949026747 0.999596102051779 0.999921173824063 0.461538461538461 0.192232441801288 0.748654517729696 0 0 0.841886116991581 0 0 0.409616397225003 0 0 20.0693212658883 1 2818.5 4975 False False 3.22937052393516 0.896338974326475 11.2217954356631 0 0 0.000389251868698371 0.999803949026747 0.999596102051779 0.999921173824063 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 5 2 6555 26503 0.000762195121951219 0.000247527523788107 0.00177780526826415 0.999924542539143 0.999727448570663 0.999990861620785 0.714285714285714 0.290420863737342 0.963307433823914 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.5345288634867 1 2276.5 4087 False False 0 0 0 0 0 0 0 10.1079328756674 1.6542054319611 106.199585900179 0 0 0.00056259979792051 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala940Ser embC_p.Ala940Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 14 0 14 0 14 9481 35691 0 0 0.00038900558066021 0.999607898053494 0.999342206985133 0.999785618166341 0 0 0.231635761650116 0 0 0.231635761650116 0 0 0.231635761650116 0 0 1.13511057396106 0.0520839153551087 96 4975 False False 0 0 1.13511057396106 0 0 0.00038900558066021 0.999607898053494 0.999342206985133 0.999785618166341 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 14 0 14 0 14 6560 26491 0 0 0.000562171107654053 0.999471797774004 0.999113925067086 0.999711197799087 0 0 0.231635761650116 0 0 0.231635761650116 0 0 0.231635761650116 0 0 1.21779664057642 0.0874873937321629 91 4087 False False 0 0 0 0 0 0 0 0 0 1.21779664057642 0 0 0.000562171107654053 0.999471797774004 0.999113925067086 0.999711197799087 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala953Gly embC_p.Ala953Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala953Ser embC_p.Ala953Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala95Thr embC_p.Ala95Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3759 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3101 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala978Val embC_p.Ala978Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ala990Pro embC_p.Ala990Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3765 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3107 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Arg1041Pro embC_p.Arg1041Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4030 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3331 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Arg1055Lys embC_p.Arg1055Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3859 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3191 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Arg1082His embC_p.Arg1082His 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3903 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3223 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Arg1082Pro embC_p.Arg1082Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3904 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3224 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Arg125Gln embC_p.Arg125Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Arg13Trp embC_p.Arg13Trp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3820 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3157 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Arg154Trp embC_p.Arg154Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3923 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3241 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Arg20His embC_p.Arg20His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 157.21479794295 1 1103 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Arg20Leu embC_p.Arg20Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 0 0 0.602364635616474 0 0 0.4592581264399 0 0 5.70483372250837 0.585894740941386 369 4975 False False 0 0 3.19822685561766 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3250 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embC p.Arg266Cys embC_p.Arg266Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.19822685561766 0.354697857676227 290 4975 False False 0 0 3.19822685561766 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 6560 26499 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.43165838346939 0.605981932438924 311.5 4087 False False 0 0 0 0 0 0 0 0 0 3.43165838346939 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Arg266His embC_p.Arg266His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Arg30_Val32del embC_p.Arg30_Val32del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Arg30Gln embC_p.Arg30Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Arg30Trp embC_p.Arg30Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 5.70499352101301 0.585896604883905 379.5 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 21.5173342675905 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Arg366Leu embC_p.Arg366Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Arg375Gln embC_p.Arg375Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Arg462Leu embC_p.Arg462Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Arg463Leu embC_p.Arg463Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Arg465Thr embC_p.Arg465Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Arg466Gln embC_p.Arg466Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embC p.Arg489Cys embC_p.Arg489Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Arg489Pro embC_p.Arg489Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3766 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Arg553Cys embC_p.Arg553Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4031 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3332 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Arg553His embC_p.Arg553His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Arg556Leu embC_p.Arg556Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Arg556Ser embC_p.Arg556Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3954 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3268 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Arg567His embC_p.Arg567His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 18 418 9463 35287 0.00189853390992511 0.00112556752776016 0.00299884872837589 0.988292956168603 0.987122632152739 0.989382810526482 0.0412844036697247 0.0246482633580351 0.064464017697536 0 0 0.975 0 0 0.00878624382991255 0 0 145.10548043632 1 NA NA False True 0.160576549209285 0.0941552746796391 0.257134404653332 0 0 0.00038974538154329 0.988292956168603 0.987122632152739 0.989382810526482 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 1 0 1 9 375 6551 26130 0.00137195121951219 0.000627529309645025 0.00260278604702639 0.985851726089417 0.984356550780405 0.987238944479318 0.0234375 0.0107718457538 0.044024063673734 0 0 0.975 0 0 0.0097887867362687 0 0 155.190611416399 1 NA NA False True 1 1 1 0 0 1 1 0.095728896351702 0.0434113252676817 0.183829856270645 0 0 0.000562943221161135 0.985851726089417 0.984356550780405 0.987238944479318 24 Not assoc w R 5) Not assoc w R No change yes 1 +Ethambutol embC p.Arg614Pro embC_p.Arg614Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Arg688Cys embC_p.Arg688Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Arg688Leu embC_p.Arg688Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Arg695Gln embC_p.Arg695Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embC p.Arg695Trp embC_p.Arg695Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4063 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3360 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Arg699Leu embC_p.Arg699Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3832 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3168 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Arg738Gln embC_p.Arg738Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 3039 39 3000 448 4518 9033 31187 0.0472523995359139 0.0430684088258109 0.0517172702336959 0.873463100406105 0.86997032589628 0.876895004685394 0.0902134514699959 0.0823873629354441 0.098525019630809 0.0128331688055281 0.00914112205020768 0.017501985867309 0.00855826201448321 0.00609263716213004 0.0116810326583065 0.0448833167275545 0.0318149919584123 0.0615683796109493 1.42549634466919e-255 NA NA False True 0.342352400550693 0.309108415960729 0.378439392022042 0.00429894179894179 0.00305870030793405 0.00587215628040025 0.873463100406105 0.86997032589628 0.876895004685394 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 2650 29 2621 327 3853 6233 22652 0.0498475609756097 0.0447060559940822 0.0553937625534036 0.854631201660064 0.850330123954474 0.858854377326491 0.0782296650717703 0.0702663459195071 0.0867881559166214 0.010943396226415 0.00734087323581796 0.0156789959163744 0.00747037609479649 0.00500857070290328 0.0107112153542642 0.0402105860714895 0.0268701621546852 0.0579591598138163 7.06823735558438e-216 NA NA False True 1 1 1 0 0 1 1 0.30843110493868 0.273707690854387 0.346636365534267 0.00463110827211753 0.00310365380322756 0.00664432379093968 0.854631201660064 0.850330123954474 0.858854377326491 1122 Not assoc w R 5) Not assoc w R No change yes 1 +Ethambutol embC p.Arg738Trp embC_p.Arg738Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Arg802His embC_p.Arg802His 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Arg806Leu embC_p.Arg806Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Arg836His embC_p.Arg836His 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Arg838Gln embC_p.Arg838Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embC p.Arg847His embC_p.Arg847His 1 missense_variant (see "Genomic_coordinates" sheet) 1 14 0 14 0 14 9481 35691 0 0 0.00038900558066021 0.999607898053494 0.999342206985133 0.999785618166341 0 0 0.231635761650116 0 0 0.231635761650116 0 0 0.231635761650116 0 0 1.13511057396106 0.0520839153551087 96 4975 False False 0 0 1.13511057396106 0 0 0.00038900558066021 0.999607898053494 0.999342206985133 0.999785618166341 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 14 0 14 0 14 6560 26491 0 0 0.000562171107654053 0.999471797774004 0.999113925067086 0.999711197799087 0 0 0.231635761650116 0 0 0.231635761650116 0 0 0.231635761650116 0 0 1.21779664057642 0.0874873937321629 91 4087 False False 0 0 0 0 0 0 0 0 0 1.21779664057642 0 0 0.000562171107654053 0.999471797774004 0.999113925067086 0.999711197799087 1 3) Uncertain significance No change no 1 +Ethambutol embC p.Arg870Leu embC_p.Arg870Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3955 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3269 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Arg877Trp embC_p.Arg877Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.10982832991351 0.590980565810755 492 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 1 3) Uncertain significance No change no 1 +Ethambutol embC p.Arg879Gly embC_p.Arg879Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 4 18 9477 35687 0.000421896424427802 0.000114964157806894 0.00107986688593449 0.99949586892592 0.999203372130377 0.999701193476901 0.181818181818181 0.0518672993124368 0.402845783077871 0 0 0.707598226178713 0 0 0.185301968137852 0 0 9.11554631240156 1 1480 4975 False False 0.836809585780779 0.2059517934771 2.54126274074989 0 0 0.000389169738041761 0.99949586892592 0.999203372130377 0.999701193476901 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 9 6557 26496 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 0.999660441426146 0.999355510362951 0.999844720818052 0.25 0.0548606445279927 0.571858461878189 0 0 0.975 0 0 0.336267116879942 0 0 157.215283426538 1 1103 4087 False False 0 0 0 0 0 0 0 1.34695745005337 0.234479688503756 5.39893908273865 0 0 0.000562428243381166 0.999660441426146 0.999355510362951 0.999844720818052 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Arg894His embC_p.Arg894His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3956 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3270 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Arg894Leu embC_p.Arg894Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3789 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3126 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Arg927His embC_p.Arg927His 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 15 9481 35690 0 0 0.00038900558066021 0.9995798907716 0.999307188228015 0.999764849596654 0 0 0.218019360910534 0 0 0.602364635616474 0 0 0.218019360910534 0 0 5.70339553597337 0.585877972430186 360 4975 False False 0 0 1.04976500705909 0 0 0.00038900558066021 0.9995798907716 0.999307188228015 0.999764849596654 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 15 6560 26490 0 0 0.000562171107654053 0.999434069043576 0.999066754461952 0.999683219243554 0 0 0.218019360910534 0 0 0.602364635616474 0 0 0.218019360910534 0 0 6.1185003044099 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 1.12620234951212 0 0 0.000562171107654053 0.999434069043576 0.999066754461952 0.999683219243554 1 3) Uncertain significance No change no 1 +Ethambutol embC p.Arg967Trp embC_p.Arg967Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3849 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3185 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Arg969His embC_p.Arg969His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Arg9Gly embC_p.Arg9Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.11527461591697 1 2818.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance No change no 1 +Ethambutol embC p.Arg9His embC_p.Arg9His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3201 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Arg9Ser embC_p.Arg9Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Asn1028Lys embC_p.Asn1028Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Asn127Ser embC_p.Asn127Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Asn176Asp embC_p.Asn176Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 146.54949493291 1 1480 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 157.208880998325 1 2276.5 4087 False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 0 0 0.000562256793434776 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance No change no 1 +Ethambutol embC p.Asn176His embC_p.Asn176His 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 1 3 1 6 9480 35699 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99983195630864 0.999634275787128 0.999938328510354 0.142857142857142 0.00361029686190058 0.578723197043195 0.25 0.00630946320970987 0.805879550316756 0.142857142857142 0.00361029686190058 0.578723197043195 1.25523909985935 0.0239079683215034 15.6333429938635 1 2818.5 4975 False False 0.627619549929676 0.0136468000350686 5.17448319653473 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 0.5 0.012579117093425 0.987420882906574 0.333333333333333 0.00840375865961264 0.905700675949754 4.04070742491233 0.0514682204381615 316.368591398696 0.357447215329094 201.5 4087 False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance No change no 1 +Ethambutol embC p.Asn176Lys embC_p.Asn176Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 4 8 9477 35697 0.000421896424427802 0.000114964157806894 0.00107986688593449 0.999775941744853 0.999558563909973 0.999903262744512 0.333333333333333 0.0992460911495833 0.651124493581186 0 0 0.409616397225003 0 0 0.369416647552819 0 0 2.61388143462778 0.357632491610281 304 4975 False False 1.88334916112693 0.414922500512465 7.03130983507434 0 0 0.000389169738041761 0.999775941744853 0.999558563909973 0.999903262744512 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 4 6 6556 26499 0.000609756097560975 0.000166162208307701 0.00156047520083291 0.99977362761743 0.99950734823901 0.999916920939814 0.4 0.121552258119827 0.737621923393055 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.43375252626493 0.605936223785692 301 4087 False False 0 0 0 0 0 0 0 2.69463087248322 0.559125120736519 11.3645694343848 0 0 0.000562514007570737 0.99977362761743 0.99950734823901 0.999916920939814 4 3) Uncertain significance No change no 1 +Ethambutol embC p.Asn394Asp embC_p.Asn394Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 308 3613 9173 32092 0.0324860246809408 0.0290089343229897 0.0362540615521409 0.898809690519535 0.895635030925368 0.901919313175411 0.0785513899515429 0.0703193518386899 0.0874177792376154 NA NA NA 0 0 0.00102048074137918 NA NA NA NA NA NA False True 0.298241548070851 0.264014149893453 0.335975026974617 0 0 0.000402064517675854 0.898809690519535 0.895635030925368 0.901919313175411 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 225 3000 6335 23505 0.0342987804878048 0.0300265546616765 0.0389911970763758 0.886813808715336 0.882938323247699 0.89060426677977 0.0697674418604651 0.0612133248332054 0.0791113247037986 NA NA NA 0 0 0.00122887080382551 NA NA NA NA NA NA False True 1 1 1 0 0 1 1 0.27827545382794 0.241225364459523 0.319724753615356 0 0 0.000582131908869974 0.886813808715336 0.882938323247699 0.89060426677977 639 Not assoc w R 5) Not assoc w R No change yes 1 +Ethambutol embC p.Asn53Lys embC_p.Asn53Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Asn60His embC_p.Asn60His 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 0 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 157.21479794295 1 1103 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Asn60Thr embC_p.Asn60Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Asn618His embC_p.Asn618His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3957 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3271 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Asn64Lys embC_p.Asn64Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethambutol embC p.Asn684Asp embC_p.Asn684Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Asn762Asp embC_p.Asn762Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Asn762Ser embC_p.Asn762Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Asn788Asp embC_p.Asn788Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Asn788Lys embC_p.Asn788Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Asn788Thr embC_p.Asn788Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3869 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Asn842Tyr embC_p.Asn842Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3924 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3242 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Asn874_Gln876del embC_p.Asn874_Gln876del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Asn874Ser embC_p.Asn874Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Asn928Tyr embC_p.Asn928Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Asp1004Gly embC_p.Asp1004Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Asp1051Asn embC_p.Asp1051Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Asp1052Ala embC_p.Asp1052Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Asp1069Asn embC_p.Asp1069Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4032 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3333 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Asp129Asn embC_p.Asp129Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Asp162Gly embC_p.Asp162Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Asp252His embC_p.Asp252His 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance No change no 1 +Ethambutol embC p.Asp274Asn embC_p.Asp274Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3833 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3169 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Asp329Asn embC_p.Asp329Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Asp329His embC_p.Asp329His 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Asp393Ala embC_p.Asp393Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3834 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3170 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Asp490Gly embC_p.Asp490Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3958 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3272 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Asp686His embC_p.Asp686His 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3767 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3108 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Asp754Asn embC_p.Asp754Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Asp775Asn embC_p.Asp775Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 24 0 24 0 26 9481 35679 0 0 0.00038900558066021 0.999271810670774 0.99893321465683 0.999524269143814 0 0 0.132274604497754 0 0 0.142473597722525 0 0 0.132274604497754 0 0 0.625401067285521 0.0050247743227775 42 4975 False False 0 0 0.573807708101142 0 0 0.00038900558066021 0.999271810670774 0.99893321465683 0.999524269143814 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 24 0 24 0 25 6560 26480 0 0 0.000562171107654053 0.999056781739294 0.998607936501749 0.999389508781733 0 0 0.137185171530712 0 0 0.142473597722525 0 0 0.137185171530712 0 0 0.670891815358955 0.00847971584961167 37 4087 False False 0 0 0 0 0 0 0 0 0 0.642044486112626 0 0 0.000562171107654053 0.999056781739294 0.998607936501749 0.999389508781733 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Asp775Glu embC_p.Asp775Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Asp793Glu embC_p.Asp793Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3959 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3273 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Asp805Asn embC_p.Asp805Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Asp811Asn embC_p.Asp811Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Asp844Asn embC_p.Asp844Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3905 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3225 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Asp844His embC_p.Asp844His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Asp878_Arg879insSerGluGlnArgAsp embC_p.Asp878_Arg879insSerGluGlnArgAsp 1 inframe_insertion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Asp878Ala embC_p.Asp878Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3737 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3084 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Asp878Gly embC_p.Asp878Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Asp892Asn embC_p.Asp892Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Asp903Glu embC_p.Asp903Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Asp948Ala embC_p.Asp948Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3906 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3226 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Asp948Tyr embC_p.Asp948Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3992 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3302 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Cys355Phe embC_p.Cys355Phe 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4049 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3350 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Cys411Arg embC_p.Cys411Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.058895521352 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance No change no 1 +Ethambutol embC p.Cys411Trp embC_p.Cys411Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Cys429Gly embC_p.Cys429Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 9.1150193618684 1 2818.5 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Cys993Arg embC_p.Cys993Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Gln1061His embC_p.Gln1061His 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.10982832991351 0.590980565810755 492 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.40943166615857 0.590385352956204 278 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Gln1071His embC_p.Gln1071His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Gln153Arg embC_p.Gln153Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Gln153His embC_p.Gln153His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Gln196His embC_p.Gln196His 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Gln491His embC_p.Gln491His 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3891 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3216 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Gln54His embC_p.Gln54His 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4033 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3334 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Gln63Glu embC_p.Gln63Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Gln705Glu embC_p.Gln705Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Gln725Arg embC_p.Gln725Arg 1 missense_variant (see "Genomic_coordinates" sheet) 2 2 0 2 4 4 9477 35701 0.000421896424427802 0.000114964157806894 0.00107986688593449 0.999887970872426 0.999713186009257 0.999969475016731 0.5 0.157012770487058 0.842987229512941 0 0 0.841886116991581 0 0 0.602364635616474 0 0 20.0667787701761 1 2818.5 4975 False False 3.76712039675002 0.701511118396156 20.2258787305262 0 0 0.000389169738041761 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 2 0 2 4 4 6556 26501 0.000609756097560975 0.000166162208307701 0.00156047520083291 0.999849085078287 0.999613643356053 0.999958879281354 0.5 0.157012770487058 0.842987229512941 0 0 0.841886116991581 0 0 0.602364635616474 0 0 21.5296282792145 1 2276.5 4087 False False 0 0 0 0 0 0 0 4.04225137278828 0.752648440329067 21.7051291323528 0 0 0.000562514007570737 0.999849085078287 0.999613643356053 0.999958879281354 1 3) Uncertain significance No change no 1 +Ethambutol embC p.Gln730His embC_p.Gln730His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Gln742Arg embC_p.Gln742Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Gln742His embC_p.Gln742His 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 5.70499352101301 0.585896604883905 379.5 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.77947080093164 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Gln955Pro embC_p.Gln955Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Glu178Lys embC_p.Glu178Lys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3738 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Glu399Asp embC_p.Glu399Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4064 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3361 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Glu4Ala embC_p.Glu4Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Glu520Gln embC_p.Glu520Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Glu667Val embC_p.Glu667Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4012 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Glu719Gly embC_p.Glu719Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.058895521352 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Glu71Lys embC_p.Glu71Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Glu783Lys embC_p.Glu783Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3940 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3256 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Glu875Gln embC_p.Glu875Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 15 0 15 0 16 9481 35689 0 0 0.00038900558066021 0.999551883489707 0.999272388596077 0.99974384169233 0 0 0.205907214207822 0 0 0.218019360910534 0 0 0.205907214207822 0 0 1.04973559585539 0.0524893866923863 101 4975 False False 0 0 0.976295497466411 0 0 0.00038900558066021 0.999551883489707 0.999272388596077 0.99974384169233 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 8 6560 26497 0 0 0.000562171107654053 0.999698170156574 0.999405361976814 0.999869682578628 0 0 0.369416647552819 0 0 0.409616397225003 0 0 0.369416647552819 0 0 2.80317025491206 0.357904627019103 207 4087 False False 0 0 0 0 0 0 0 0 0 2.36695385477914 0 0 0.000562171107654053 0.999698170156574 0.999405361976814 0.999869682578628 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Glu904Lys embC_p.Glu904Lys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3892 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3217 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Gly1002Asp embC_p.Gly1002Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 1 9478 35704 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999971992718106 0.999843963402622 0.999999290917266 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 146.584444274952 1 1480 4975 False False 11.3011183794049 0.90722384791697 591.183089908516 0 0 0.000389128685709026 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 1 6557 26504 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 0.999962271269571 0.999789807096406 0.999999044791703 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 157.262633381485 1 1103 4087 False False 0 0 0 0 0 0 0 12.1262772609425 0.973374031902014 634.171386087929 0 0 0.000562428243381166 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embC p.Gly101Ala embC_p.Gly101Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Gly149Cys embC_p.Gly149Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3993 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3303 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Gly149Ser embC_p.Gly149Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3870 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3202 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Gly174Arg embC_p.Gly174Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 10 0 10 0 10 9481 35695 0 0 0.00038900558066021 0.999719927181067 0.999484996631079 0.999865686288203 0 0 0.30849710781876 0 0 0.30849710781876 0 0 0.30849710781876 0 0 1.67996531074212 0.134582133412278 140.5 4975 False False 0 0 1.67996531074212 0 0 0.00038900558066021 0.999719927181067 0.999484996631079 0.999865686288203 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.40943166615857 0.590385352956204 278 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Gly186Ala embC_p.Gly186Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Gly186Arg embC_p.Gly186Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4050 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3351 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Gly186Asp embC_p.Gly186Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Gly186Cys embC_p.Gly186Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 5 9480 35700 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999859963590533 0.999673232250017 0.999954529045718 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.707598226178713 0 0 0.521823750104981 0 0 9.11598072092185 1 2818.5 4975 False False 0.753164556962025 0.0159260191955521 6.73154939272228 0 0 0.00038904660702099 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 157.179059039538 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Gly190Ser embC_p.Gly190Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Gly206Glu embC_p.Gly206Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Gly211Ala embC_p.Gly211Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Gly237Ala embC_p.Gly237Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 12 1 11 1 11 9480 35694 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999691919899173 0.999448826618347 0.999846197812 0.0833333333333333 0.00210759323186022 0.384796165150944 0.0833333333333333 0.00210759323186022 0.384796165150944 0.0833333333333333 0.00210759323186022 0.384796165150944 0.34228998849252 0.00795492252872522 2.35571643249047 0.480141440771846 346 4975 False False 0.34228998849252 0.00795492252872522 2.35571643249047 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999691919899173 0.999448826618347 0.999846197812 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 1 9 1 9 6559 26496 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999660441426146 0.999355510362951 0.999844720818052 0.1 0.00252857854446178 0.445016117028195 0.1 0.00252857854446178 0.445016117028195 0.1 0.00252857854446178 0.445016117028195 0.448848909894801 0.0102423495192947 3.24032619577018 0.697988513863566 332 4087 False False 0 0 0 0 0 0 0 0.448848909894801 0.0102423495192947 3.24032619577018 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999660441426146 0.999355510362951 0.999844720818052 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Gly23Arg embC_p.Gly23Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Gly23Glu embC_p.Gly23Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 10 0 10 4 12 9477 35693 0.000421896424427802 0.000114964157806894 0.00107986688593449 0.99966391261728 0.999412996653316 0.999826327071809 0.25 0.0726620382528822 0.523770819896127 0 0 0.30849710781876 0 0 0.264648469397051 0 0 1.68058017152607 0.134609388676787 145 4975 False False 1.25542541591924 0.295037488647637 4.14356889249059 0 0 0.000389169738041761 0.99966391261728 0.999412996653316 0.999826327071809 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 4 12 6556 26493 0.000609756097560975 0.000166162208307701 0.00156047520083291 0.999547255234861 0.999209279704825 0.999766038988972 0.25 0.0726620382528822 0.523770819896127 0 0 0.30849710781876 0 0 0.264648469397051 0 0 1.8034432528557 0.227511702686447 174.5 4087 False False 0 0 0 0 0 0 0 1.34701037217815 0.316548965477252 4.44644173737944 0 0 0.000562514007570737 0.999547255234861 0.999209279704825 0.999766038988972 2 3) Uncertain significance No change no 1 +Ethambutol embC p.Gly242Ser embC_p.Gly242Ser 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 0 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 157.21479794295 1 1103 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Gly272Ser embC_p.Gly272Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Gly37Asp embC_p.Gly37Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3790 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3127 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Gly383Asp embC_p.Gly383Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Gly383Ser embC_p.Gly383Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Gly432Ser embC_p.Gly432Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3739 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3085 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Gly454Arg embC_p.Gly454Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance No change no 1 +Ethambutol embC p.Gly454Trp embC_p.Gly454Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4021 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3324 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Gly468Ser embC_p.Gly468Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Gly559Arg embC_p.Gly559Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3740 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3086 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Gly559Asp embC_p.Gly559Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Gly563Glu embC_p.Gly563Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3871 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3203 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Gly601Glu embC_p.Gly601Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Gly610Ala embC_p.Gly610Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Gly610Ser embC_p.Gly610Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Gly647Ser embC_p.Gly647Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Gly687Glu embC_p.Gly687Glu 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 0 1 3 25 9478 35680 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999299817952667 0.998966565499085 0.999546829455204 0.107142857142857 0.0226650906390589 0.282264395715324 0 0 0.975 0 0 0.137185171530712 0 0 146.486139431328 1 2818.5 4975 False False 0.451740873602025 0.0872821830420128 1.48096997640547 0 0 0.000389128685709026 0.999299817952667 0.998966565499085 0.999546829455204 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3257 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Gly750Arg embC_p.Gly750Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3768 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Gly764Asp embC_p.Gly764Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Gly764Val embC_p.Gly764Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Gly780Asp embC_p.Gly780Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3791 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Gly804Glu embC_p.Gly804Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Gly813Glu embC_p.Gly813Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Gly817Asp embC_p.Gly817Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embC p.Gly821Ser embC_p.Gly821Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Gly825Val embC_p.Gly825Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Gly831Arg embC_p.Gly831Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Gly852Asp embC_p.Gly852Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Gly857Ser embC_p.Gly857Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0615661524565 1 2818.5 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.5214194708504 1 2276.5 4087 False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 0 0 0.000562256793434776 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Gly909Glu embC_p.Gly909Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4045 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3346 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Gly921Asp embC_p.Gly921Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embC p.Gly976Arg embC_p.Gly976Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3925 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3243 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Gly976Asp embC_p.Gly976Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3810 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Gly976Ser embC_p.Gly976Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 12 0 12 0 12 9481 35693 0 0 0.00038900558066021 0.99966391261728 0.999412996653316 0.999826327071809 0 0 0.264648469397051 0 0 0.264648469397051 0 0 0.264648469397051 0 0 1.35519147325258 0.0835905265175333 111 4975 False False 0 0 1.35519147325258 0 0 0.00038900558066021 0.99966391261728 0.999412996653316 0.999826327071809 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 12 0 12 0 12 6560 26493 0 0 0.000562171107654053 0.999547255234861 0.999209279704825 0.999766038988972 0 0 0.264648469397051 0 0 0.264648469397051 0 0 0.264648469397051 0 0 1.45386850159099 0.140764243939364 113 4087 False False 0 0 0 0 0 0 0 0 0 1.45386850159099 0 0 0.000562171107654053 0.999547255234861 0.999209279704825 0.999766038988972 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Gly988Glu embC_p.Gly988Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.His1027Gln embC_p.His1027Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.His336Gln embC_p.His336Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3850 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3186 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.His369_Ala370insAsp embC_p.His369_Ala370insAsp 1 inframe_insertion (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4056 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.His369Gln embC_p.His369Gln 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3893 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.His910Asn embC_p.His910Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.His910Tyr embC_p.His910Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.His911Gln embC_p.His911Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethambutol embC p.His956Arg embC_p.His956Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3960 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3274 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.His999Tyr embC_p.His999Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3882 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3210 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Ile1011Val embC_p.Ile1011Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.096562813829025 Inf 0.209821626167397 198.5 4975 False False Inf 0.096562813829025 Inf 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Ile1035Val embC_p.Ile1035Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ile10Thr embC_p.Ile10Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3821 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3158 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ile235Val embC_p.Ile235Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3851 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3187 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Ile28Val embC_p.Ile28Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ile364Asn embC_p.Ile364Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3982 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3294 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Ile364Leu embC_p.Ile364Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Ile406Val embC_p.Ile406Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 12 0 12 4 14 9477 35691 0.000421896424427802 0.000114964157806894 0.00107986688593449 0.999607898053494 0.999342206985133 0.999785618166341 0.222222222222222 0.0640920477176664 0.47637276573648 0 0 0.264648469397051 0 0 0.231635761650116 0 0 1.35568758093206 0.0836118558275113 117 4975 False False 1.07601863157418 0.257834466158144 3.42722990821387 0 0 0.000389169738041761 0.999607898053494 0.999342206985133 0.999785618166341 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 4 12 6556 26493 0.000609756097560975 0.000166162208307701 0.00156047520083291 0.999547255234861 0.999209279704825 0.999766038988972 0.25 0.0726620382528822 0.523770819896127 0 0 0.30849710781876 0 0 0.264648469397051 0 0 1.8034432528557 0.227511702686447 174.5 4087 False False 0 0 0 0 0 0 0 1.34701037217815 0.316548965477252 4.44644173737944 0 0 0.000562514007570737 0.999547255234861 0.999209279704825 0.999766038988972 1 3) Uncertain significance No change no 1 +Ethambutol embC p.Ile427Val embC_p.Ile427Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ile430Leu embC_p.Ile430Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3994 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3304 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Ile430Ser embC_p.Ile430Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ile430Thr embC_p.Ile430Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ile431Val embC_p.Ile431Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Ile459Met embC_p.Ile459Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ile459Thr embC_p.Ile459Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Ile459Val embC_p.Ile459Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 0 0 0.707598226178713 0 0 0.4592581264399 0 0 9.11476410780766 1 1480 4975 False False 0 0 3.19822685561766 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.841886116991581 0 0 0.521823750104981 0 0 21.5157135377061 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ile45Thr embC_p.Ile45Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Ile487Thr embC_p.Ile487Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ile497Met embC_p.Ile497Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 10 13 9471 35692 0.0010547410610695 0.00050590153672643 0.00193884812290577 0.999635905335387 0.999377467513205 0.999806121137399 0.434782608695652 0.231914199538231 0.655053392547625 0 0 0.369416647552819 0 0 0.24705263800047 0 0 2.20818854059868 0.217761729836019 239 4975 False False 2.89888972815802 1.13745002997837 7.15921342171799 0 0 0.000389416234052975 0.999635905335387 0.999377467513205 0.999806121137399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 10 12 6550 26493 0.00152439024390243 0.000731238785140689 0.00280161526425175 0.999547255234861 0.999209279704825 0.999766038988972 0.454545454545454 0.243861865923016 0.677895245446828 0 0 0.369416647552819 0 0 0.264648469397051 0 0 2.37021037226541 0.369881652116395 219 4087 False False 0 0 0 0 0 0 0 3.3706106870229 1.30377522471053 8.51724204599417 0 0 0.000563029142491623 0.999547255234861 0.999209279704825 0.999766038988972 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ile517Val embC_p.Ile517Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embC p.Ile557Thr embC_p.Ile557Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3907 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Ile568Met embC_p.Ile568Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ile571Phe embC_p.Ile571Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Ile573Thr embC_p.Ile573Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 4.10971321225031 0.590981128432313 516.5 4975 False False 0 0 3.19822685561766 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 6.12080991862283 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 1 3) Uncertain significance No change no 1 +Ethambutol embC p.Ile728Val embC_p.Ile728Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ile815Thr embC_p.Ile815Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ile832Val embC_p.Ile832Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 0 9 0 11 9481 35694 0 0 0.00038900558066021 0.999691919899173 0.999448826618347 0.999846197812 0 0 0.284914152918154 0 0 0.336267116879942 0 0 0.284914152918154 0 0 1.90775632399327 0.219223612419558 252.5 4975 False False 0 0 1.50034693324555 0 0 0.00038900558066021 0.999691919899173 0.999448826618347 0.999846197812 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 0 10 6560 26495 0 0 0.000562171107654053 0.999622712695717 0.999306265033238 0.999819061720012 0 0 0.30849710781876 0 0 0.336267116879942 0 0 0.30849710781876 0 0 2.04683374325628 0.220130286309629 162 4087 False False 0 0 0 0 0 0 0 0 0 1.80248078294835 0 0 0.000562171107654053 0.999622712695717 0.999306265033238 0.999819061720012 3 3) Uncertain significance No change no 1 +Ethambutol embC p.Ile936Val embC_p.Ile936Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3741 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3087 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ile958Leu embC_p.Ile958Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ile965Leu embC_p.Ile965Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3860 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3192 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Leu1012Met embC_p.Leu1012Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Leu1049Val embC_p.Leu1049Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 1 9479 35704 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999971992718106 0.999843963402622 0.999999290917266 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 4057 4975 False False 7.53328410169849 0.392120325718966 443.147628387906 0 0 0.000389087642036349 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3356 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Leu14Ile embC_p.Leu14Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 1 8 9480 35697 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999775941744853 0.999558563909973 0.999903262744512 0.111111111111111 0.00280913674659921 0.482496514917337 0 0 0.409616397225003 0 0 0.369416647552819 0 0 2.61305419526464 0.357637611355835 307 4975 False False 0.47068829113924 0.010610026508271 3.51159115085171 0 0 0.00038904660702099 0.999775941744853 0.999558563909973 0.999903262744512 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 1 8 6559 26497 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999698170156574 0.999405361976814 0.999869682578628 0.111111111111111 0.00280913674659921 0.482496514917337 0 0 0.409616397225003 0 0 0.369416647552819 0 0 2.80359764916143 0.357908279590236 216 4087 False False 0 0 0 0 0 0 0 0.504974081414849 0.0113820510464553 3.76768363928727 0 0 0.000562256793434776 0.999698170156574 0.999405361976814 0.999869682578628 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Leu212Pro embC_p.Leu212Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Leu229Arg embC_p.Leu229Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Leu236Pro embC_p.Leu236Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Leu236Val embC_p.Leu236Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Leu240Pro embC_p.Leu240Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Leu251Arg embC_p.Leu251Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 1 4 1 4 9480 35701 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999887970872426 0.999713186009257 0.999969475016731 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 0.941482067510548 0.0191153149568561 9.51304376083015 1 2818.5 4975 False False 0.941482067510548 0.0191153149568561 9.51304376083015 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 1 4 1 4 6559 26501 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999849085078287 0.999613643356053 0.999958879281354 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 1.01010062509528 0.0205075656450505 10.2127021503241 1 2276.5 4087 False False 0 0 0 0 0 0 0 1.01010062509528 0.0205075656450505 10.2127021503241 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Leu331Pro embC_p.Leu331Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Leu333Arg embC_p.Leu333Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 0 8 9481 35697 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 2.20624116275339 0.217681019156043 228.5 4975 False False 0 0 2.20624116275339 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 0 8 6560 26497 0 0 0.000562171107654053 0.999698170156574 0.999405361976814 0.999869682578628 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 2.36695385477914 0.369987659436533 226 4087 False False 0 0 0 0 0 0 0 0 0 2.36695385477914 0 0 0.000562171107654053 0.999698170156574 0.999405361976814 0.999869682578628 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Leu39Pro embC_p.Leu39Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3861 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3193 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Leu43Pro embC_p.Leu43Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3801 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3137 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Leu450Met embC_p.Leu450Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3961 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3275 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Leu460Arg embC_p.Leu460Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3872 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3204 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Leu470Pro embC_p.Leu470Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3894 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Leu472Met embC_p.Leu472Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Leu477Gln embC_p.Leu477Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Leu502Phe embC_p.Leu502Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3873 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3205 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Leu50Pro embC_p.Leu50Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Leu50Val embC_p.Leu50Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Leu603Arg embC_p.Leu603Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Leu661Ile embC_p.Leu661Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 67 9480 35638 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.998123512113149 0.997617530501414 0.998545460831816 0.0147058823529411 0.00037225140289861 0.079233989912788 NA NA NA 0 0 0.0535696541270968 NA NA NA NA NA NA False True 0.056108697021223 0.00140390558670019 0.323596085614818 0 0 0.00038904660702099 0.998123512113149 0.997617530501414 0.998545460831816 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 1 58 6559 26447 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.997811733635163 0.997172064607892 0.998337951124302 0.0169491525423728 0.000429023332723594 0.0908559328866492 NA NA NA 0 0 0.0616210089039198 NA NA NA NA NA NA False True 1 1 1 0 0 1 1 0.069520164448954 0.00173441509351777 0.403138407665929 0 0 0.000562256793434776 0.997811733635163 0.997172064607892 0.998337951124302 1 Not assoc w R 5) Not assoc w R No change yes 1 +Ethambutol embC p.Leu675del embC_p.Leu675del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Leu700Val embC_p.Leu700Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Leu714Phe embC_p.Leu714Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4034 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3335 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Leu741Val embC_p.Leu741Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Leu744Ser embC_p.Leu744Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Leu766Pro embC_p.Leu766Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Leu814Pro embC_p.Leu814Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Leu94del embC_p.Leu94del 1 inframe_deletion (see "Genomic_coordinates" sheet) 2 2 0 2 2 3 9479 35702 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.99991597815432 0.999754472342108 0.99998267234027 0.4 0.0527449505263169 0.853367200365326 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.0631165181962 1 2818.5 4975 False False 2.51095403875232 0.209684820120099 21.9222407664312 0 0 0.000389087642036349 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 0 1 2 2 6558 26503 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999924542539143 0.999727448570663 0.999990861620785 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 157.232794181633 1 2276.5 4087 False False 0 0 0 0 0 0 0 4.04132357426044 0.292866339798886 55.7129032982466 0 0 0.00056234250533983 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance No change no 1 +Ethambutol embC p.Leu94Val embC_p.Leu94Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 2 2 9479 35703 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999943985436213 0.999797670939776 0.99999321630447 0.5 0.067585986488543 0.932414013511457 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0636769343408 1 2818.5 4975 False False 3.76653655448887 0.272970929153834 51.9466713138689 0 0 0.000389087642036349 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 6558 26504 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999962271269571 0.999789807096406 0.999999044791703 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 157.238712024072 1 1103 4087 False False 0 0 0 0 0 0 0 8.08295211954864 0.420719628662148 475.373667785977 0 0 0.00056234250533983 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embC p.Leu983Arg embC_p.Leu983Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4013 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Lys1008Asn embC_p.Lys1008Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3962 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3276 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Lys102Asn embC_p.Lys102Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Lys511Arg embC_p.Lys511Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Lys511Asn embC_p.Lys511Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Lys656Asn embC_p.Lys656Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 26 0 26 2 29 9479 35676 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999187788825094 0.998833735901384 0.999455984066987 0.064516129032258 0.0079109834618547 0.214216157163402 0 0 0.132274604497754 0 0 0.119444869069502 0 0 0.573880579542374 0.00315972022971856 37 4975 False False 0.259564700190257 0.0300098692479299 1.02636833956768 0 0 0.000389087642036349 0.999187788825094 0.998833735901384 0.999455984066987 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 21 0 21 0 23 6560 26482 0 0 0.000562171107654053 0.99913223920015 0.998698215498625 0.999449837068455 0 0 0.148185128915224 0 0 0.161097615219079 0 0 0.148185128915224 0 0 0.775486515839429 0.0134214614484193 43.5 4087 False False 0 0 0 0 0 0 0 0 0 0.702513080401621 0 0 0.000562171107654053 0.99913223920015 0.998698215498625 0.999449837068455 2 3) Uncertain significance No change no 1 +Ethambutol embC p.Met1040Thr embC_p.Met1040Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance No change no 1 +Ethambutol embC p.Met231Ile embC_p.Met231Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Met234Ile embC_p.Met234Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embC p.Met234Leu embC_p.Met234Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3883 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3211 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Met310Thr embC_p.Met310Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3983 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3295 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Met351Ile embC_p.Met351Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Met351Thr embC_p.Met351Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 11 2 9 2 9 9479 35696 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.99974793446296 0.999521555266748 0.999884733314884 0.181818181818181 0.0228311982999596 0.517755852360172 0.181818181818181 0.0228311982999596 0.517755852360172 0.181818181818181 0.0228311982999596 0.517755852360172 0.836844017770275 0.0879719531671099 4.04425008799206 1 2818.5 4975 False False 0.836844017770275 0.0879719531671099 4.04425008799206 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.99974793446296 0.999521555266748 0.999884733314884 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Met524Ile embC_p.Met524Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Met550Ile embC_p.Met550Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Met579Leu embC_p.Met579Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3914 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3232 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Met613Ile embC_p.Met613Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethambutol embC p.Met613Val embC_p.Met613Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 55 29 9426 35676 0.00580107583588229 0.00437306604898261 0.00754428585911559 0.999187788825094 0.998833735901384 0.999455984066987 0.654761904761904 0.543075701683785 0.755184714869439 0 0 0.975 0 0 0.119444869069502 0 0 147.27591911192 1 2818.5 4975 False False 7.17816457780021 4.49578900143807 11.682161218889 0 0 0.00039127495480279 0.999187788825094 0.998833735901384 0.999455984066987 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 52 24 6508 26481 0.00792682926829268 0.00592563866907346 0.0103821398860486 0.999094510469722 0.998653000996664 0.999419752318005 0.684210526315789 0.567452098193474 0.786105407745419 0 0 0.975 0 0 0.142473597722525 0 0 158.306611831935 1 2276.5 4087 False False 0 0 0 0 0 0 0 8.81614935464044 5.33246821668011 14.9669863934815 0 0 0.000566661675179857 0.999094510469722 0.998653000996664 0.999419752318005 1 3) Uncertain significance No change no 1 +Ethambutol embC p.Met727Val embC_p.Met727Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Met800Ile embC_p.Met800Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 9 9481 35696 0 0 0.00038900558066021 0.99974793446296 0.999521555266748 0.999884733314884 0 0 0.336267116879942 0 0 0.707598226178713 0 0 0.336267116879942 0 0 9.11399834555253 1 3243.5 4975 False False 0 0 1.90786321657339 0 0 0.00038900558066021 0.99974793446296 0.999521555266748 0.999884733314884 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 7 6560 26498 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 0 0 0.409616397225003 0 0 0.841886116991581 0 0 0.409616397225003 0 0 21.5140928090121 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 2.80327602229365 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 3 3) Uncertain significance No change no 1 +Ethambutol embC p.Met915Thr embC_p.Met915Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Phe1016Ser embC_p.Phe1016Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Phe157Leu embC_p.Phe157Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 157.21479794295 1 1103 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Phe214Ser embC_p.Phe214Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Phe262Cys embC_p.Phe262Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Phe286Leu embC_p.Phe286Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3884 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethambutol embC p.Phe317Ser embC_p.Phe317Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3852 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Phe385Ser embC_p.Phe385Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3781 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3120 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Phe437Ser embC_p.Phe437Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4022 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3325 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Phe467Leu embC_p.Phe467Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Phe535Ile embC_p.Phe535Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.11527461591697 1 2818.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.77947080093164 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Phe535Leu embC_p.Phe535Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3895 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3218 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Phe581Leu embC_p.Phe581Leu 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3138 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Phe581Val embC_p.Phe581Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Phe654Leu embC_p.Phe654Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Phe67Val embC_p.Phe67Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 2 3 9479 35702 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.99991597815432 0.999754472342108 0.99998267234027 0.4 0.0527449505263169 0.853367200365326 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.0631165181962 1 2818.5 4975 False False 2.51095403875232 0.209684820120099 21.9222407664312 0 0 0.000389087642036349 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.5214194708504 1 2276.5 4087 False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 0 0 0.000562256793434776 0.999924542539143 0.999727448570663 0.999990861620785 3 3) Uncertain significance No change no 1 +Ethambutol embC p.Phe891Leu embC_p.Phe891Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Phe891Tyr embC_p.Phe891Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3782 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3121 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Phe982Ile embC_p.Phe982Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 12 9481 35693 0 0 0.00038900558066021 0.99966391261728 0.999412996653316 0.999826327071809 0 0 0.264648469397051 0 0 0.602364635616474 0 0 0.264648469397051 0 0 5.70387493148367 0.585883560539189 361 4975 False False 0 0 1.35519147325258 0 0 0.00038900558066021 0.99966391261728 0.999412996653316 0.999826327071809 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 11 6560 26494 0 0 0.000562171107654053 0.999584983965289 0.999257543293353 0.999792807866341 0 0 0.284914152918154 0 0 0.707598226178713 0 0 0.284914152918154 0 0 9.77688861360045 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 1.60965686204705 0 0 0.000562171107654053 0.999584983965289 0.999257543293353 0.999792807866341 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Phe991Leu embC_p.Phe991Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Pro1065Leu embC_p.Pro1065Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 1 6 9480 35699 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99983195630864 0.999634275787128 0.999938328510354 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.521823750104981 0 0 0.4592581264399 0 0 4.11014678537513 0.590979008627141 471.5 4975 False False 0.627619549929676 0.0136468000350686 5.17448319653473 0 0 0.00038904660702099 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 1 6 6559 26499 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.99977362761743 0.99950734823901 0.999916920939814 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.521823750104981 0 0 0.4592581264399 0 0 4.40993766087508 0.590385727717902 294 4087 False False 0 0 0 0 0 0 0 0.673349595974996 0.0146401601947477 5.55241977196973 0 0 0.000562256793434776 0.99977362761743 0.99950734823901 0.999916920939814 1 3) Uncertain significance No change no 1 +Ethambutol embC p.Pro1068Ser embC_p.Pro1068Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Pro1072Leu embC_p.Pro1072Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4001 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Pro1090Thr embC_p.Pro1090Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3995 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3305 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Pro110Ser embC_p.Pro110Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 8 0 9473 35705 0.000843792848855605 0.000364358012393849 0.00166192766222289 1 0.999896689850119 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 3835 4975 False False Inf 6.43199985370502 Inf 0 0 0.000389334034028122 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 5 0 6555 26505 0.000762195121951219 0.000247527523788107 0.00177780526826415 1 0.999860832946126 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 3171 4087 False False 0 0 0 0 0 0 0 Inf 3.70403509656001 Inf 0 0 0.00056259979792051 1 0.999860832946126 1 1 3) Uncertain significance No change no 1 +Ethambutol embC p.Pro114Leu embC_p.Pro114Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Pro138Ser embC_p.Pro138Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Pro150Ser embC_p.Pro150Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Pro150Thr embC_p.Pro150Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embC p.Pro175Thr embC_p.Pro175Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Pro210Ala embC_p.Pro210Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3862 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3194 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Pro210Ser embC_p.Pro210Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Pro226Ser embC_p.Pro226Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Pro264His embC_p.Pro264His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Pro320Ser embC_p.Pro320Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Pro391Ser embC_p.Pro391Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3792 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3128 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 2 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Pro424Leu embC_p.Pro424Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Pro486Thr embC_p.Pro486Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 4.10971321225031 0.590981128432313 516.5 4975 False False 0 0 3.19822685561766 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12104088004766 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 1 3) Uncertain significance No change no 1 +Ethambutol embC p.Pro51Leu embC_p.Pro51Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Pro558Arg embC_p.Pro558Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Pro558Leu embC_p.Pro558Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Pro564Gln embC_p.Pro564Gln 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3915 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3233 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Pro564Leu embC_p.Pro564Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Pro62Leu embC_p.Pro62Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Pro62Ser embC_p.Pro62Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3874 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3206 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Pro649Ser embC_p.Pro649Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3822 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3159 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Pro693Ser embC_p.Pro693Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3742 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Pro707Leu embC_p.Pro707Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Pro732Ala embC_p.Pro732Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3963 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3277 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 2 3) Uncertain significance No change no 1 +Ethambutol embC p.Pro73Gln embC_p.Pro73Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.058895521352 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 21.5173342675905 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 1 3) Uncertain significance No change no 1 +Ethambutol embC p.Pro772Ala embC_p.Pro772Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Pro772Ser embC_p.Pro772Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Pro787Ser embC_p.Pro787Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Pro791Thr embC_p.Pro791Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Pro798Gln embC_p.Pro798Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3975 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3289 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Pro7Ser embC_p.Pro7Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Pro820Leu embC_p.Pro820Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3984 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3296 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Pro845Arg embC_p.Pro845Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Pro849Leu embC_p.Pro849Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Pro849Ser embC_p.Pro849Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Pro861Leu embC_p.Pro861Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Pro924Leu embC_p.Pro924Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Pro962Ser embC_p.Pro962Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Pro992Leu embC_p.Pro992Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3885 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3212 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Pro996Thr embC_p.Pro996Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3896 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3219 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ser107Ala embC_p.Ser107Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3743 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3088 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ser18Phe embC_p.Ser18Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 10 0 10 0 10 9481 35695 0 0 0.00038900558066021 0.999719927181067 0.999484996631079 0.999865686288203 0 0 0.30849710781876 0 0 0.30849710781876 0 0 0.30849710781876 0 0 1.67996531074212 0.134582133412278 140.5 4975 False False 0 0 1.67996531074212 0 0 0.00038900558066021 0.999719927181067 0.999484996631079 0.999865686288203 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 0 8 6560 26497 0 0 0.000562171107654053 0.999698170156574 0.999405361976814 0.999869682578628 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 2.36695385477914 0.369987659436533 226 4087 False False 0 0 0 0 0 0 0 0 0 2.36695385477914 0 0 0.000562171107654053 0.999698170156574 0.999405361976814 0.999869682578628 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ser213Asn embC_p.Ser213Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 5.70499352101301 0.585896604883905 379.5 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 6.12080991862283 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ser215Ala embC_p.Ser215Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethambutol embC p.Ser225Arg embC_p.Ser225Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.10982832991351 0.590980565810755 492 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12104088004766 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ser269Leu embC_p.Ser269Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ser304Pro embC_p.Ser304Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Ser420Gly embC_p.Ser420Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ser438Ala embC_p.Ser438Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Ser547Leu embC_p.Ser547Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ser551Trp embC_p.Ser551Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ser565Gly embC_p.Ser565Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0615661524565 1 2818.5 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.5214194708504 1 2276.5 4087 False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 0 0 0.000562256793434776 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ser651Pro embC_p.Ser651Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ser69Arg embC_p.Ser69Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Ser729Phe embC_p.Ser729Phe 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4023 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Thr1006Ile embC_p.Thr1006Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3934 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3251 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Thr1036Asn embC_p.Thr1036Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Thr1044Lys embC_p.Thr1044Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Thr1044Met embC_p.Thr1044Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 146.529978407112 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 157.179059039538 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Thr1044Pro embC_p.Thr1044Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3926 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3244 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embC p.Thr1079Ala embC_p.Thr1079Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Thr151Ile embC_p.Thr151Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Thr158Ile embC_p.Thr158Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Thr220Ile embC_p.Thr220Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.841886116991581 0 0 0.521823750104981 0 0 20.0577749283512 1 2818.5 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.841886116991581 0 0 0.521823750104981 0 0 21.5157135377061 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Thr227Lys embC_p.Thr227Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12104088004766 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Thr241Ile embC_p.Thr241Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Thr241Ser embC_p.Thr241Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Thr253Ile embC_p.Thr253Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Thr270Ile embC_p.Thr270Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 326 3888 9155 31817 0.0343845585908659 0.0308076825514565 0.0382510515001011 0.891107687998879 0.887830741183491 0.894320865842172 0.0773611770289511 0.0694712442757644 0.0858427085209719 0 0 0.841886116991581 0 0 0.000948335912831061 0 0 18.5067768557089 1 NA NA False True 0.291401795326487 0.258868687383898 0.327168037832425 0 0 0.000402854873040105 0.891107687998879 0.887830741183491 0.894320865842172 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 2 0 2 243 3246 6317 23259 0.0370426829268292 0.0326029506629165 0.0418997959692027 0.877532541029994 0.873525618538304 0.881456494346877 0.0696474634565778 0.0614210804750973 0.0786034635412915 0 0 0.841886116991581 0 0 0.00113579302389128 0 0 19.6153226243631 1 NA NA False True 1 1 1 0 0 1 1 0.275637257326048 0.24026214403411 0.315088386082616 0 0 0.0005837901826042 0.877532541029994 0.873525618538304 0.881456494346877 673 Not assoc w R 5) Not assoc w R No change yes 1 +Ethambutol embC p.Thr275Ile embC_p.Thr275Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4024 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3326 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Thr319Ala embC_p.Thr319Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Thr319Ile embC_p.Thr319Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3916 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3234 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Thr380Met embC_p.Thr380Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Thr409Ala embC_p.Thr409Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Thr492Ala embC_p.Thr492Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3985 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3297 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Thr492Asn embC_p.Thr492Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 7 9481 35698 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 2.61285174975179 0.357638874560194 311 4975 False False 0 0 2.61285174975179 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethambutol embC p.Thr572Ala embC_p.Thr572Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Thr609Ala embC_p.Thr609Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3875 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Thr609Ser embC_p.Thr609Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3836 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3172 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Thr620Ile embC_p.Thr620Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 157.21479794295 1 1103 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Thr663Asn embC_p.Thr663Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12104088004766 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Thr66Pro embC_p.Thr66Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethambutol embC p.Thr712Ala embC_p.Thr712Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embC p.Thr724Ala embC_p.Thr724Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3886 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Thr748Ile embC_p.Thr748Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3986 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3298 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Thr770Ala embC_p.Thr770Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3760 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3102 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Thr786Ala embC_p.Thr786Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3863 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3195 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Thr786Ile embC_p.Thr786Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 1 9477 35704 0.000421896424427802 0.000114964157806894 0.00107986688593449 0.999971992718106 0.999843963402622 0.999999290917266 0.8 0.28358206388191 0.994949236620532 NA NA NA 0 0 0.975 NA NA NA NA 3793 4975 False False 15.0697478104885 1.49093500364622 739.038051857485 0 0 0.000389169738041761 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 1 6556 26504 0.000609756097560975 0.000166162208307701 0.00156047520083291 0.999962271269571 0.999789807096406 0.999999044791703 0.8 0.28358206388191 0.994949236620532 NA NA NA 0 0 0.975 NA NA NA NA 3129 4087 False False 0 0 0 0 0 0 0 16.1708358755338 1.59970034177407 792.771744020614 0 0 0.000562514007570737 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Thr795Ala embC_p.Thr795Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Thr816Ala embC_p.Thr816Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3853 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Thr822Pro embC_p.Thr822Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4046 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3347 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Thr827Pro embC_p.Thr827Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.096562813829025 Inf 0.209821626167397 198.5 4975 False False Inf 0.096562813829025 Inf 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Thr873Ala embC_p.Thr873Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Thr886Ala embC_p.Thr886Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3976 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Thr939Ile embC_p.Thr939Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3887 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3213 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Thr941Ala embC_p.Thr941Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3888 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3214 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Trp1053Arg embC_p.Trp1053Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Trp1053Cys embC_p.Trp1053Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Trp268Cys embC_p.Trp268Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Trp326Cys embC_p.Trp326Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3987 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Trp343Leu embC_p.Trp343Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Trp389Cys embC_p.Trp389Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Tyr1066His embC_p.Tyr1066His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Tyr327Cys embC_p.Tyr327Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3761 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3103 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Val104Met embC_p.Val104Met 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 23 339 9458 35366 0.00242590444045986 0.00153841761553811 0.00363783762977583 0.990505531438174 0.989444724388421 0.99148536184601 0.0635359116022099 0.0406990806065335 0.0938122626947062 NA NA NA 0 0 0.0108226593174154 NA NA NA NA NA NA False True 0.253696672324345 0.15852687723962 0.387403446849523 0 0 0.000389951381427405 0.990505531438174 0.989444724388421 0.99148536184601 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 10 299 6550 26206 0.00152439024390243 0.000731238785140689 0.00280161526425175 0.988719109601962 0.987373803009162 0.989955603574595 0.0323624595469255 0.0156260357184044 0.0587089446744643 NA NA NA 0 0 0.012261595907535 NA NA NA NA NA NA False True 1 1 1 0 0 1 1 0.133809900686767 0.0635032654621424 0.249736550994131 0 0 0.000563029142491623 0.988719109601962 0.987373803009162 0.989955603574595 24 Not assoc w R 5) Not assoc w R No change yes 1 +Ethambutol embC p.Val109Met embC_p.Val109Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Val131Ala embC_p.Val131Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3941 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3258 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Val140Ile embC_p.Val140Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Val147Met embC_p.Val147Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4025 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Val169Ile embC_p.Val169Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.058895521352 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 21.5173342675905 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Val198Phe embC_p.Val198Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Val19Ala embC_p.Val19Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 146.54949493291 1 1480 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Val19Leu embC_p.Val19Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Val19Met embC_p.Val19Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.058895521352 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 21.5173342675905 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Val218Ala embC_p.Val218Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Val238Ile embC_p.Val238Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Val246Ala embC_p.Val246Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.10982832991351 0.590980565810755 492 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.40943166615857 0.590385352956204 278 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Val246Met embC_p.Val246Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Val277del embC_p.Val277del 1 inframe_deletion (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3823 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Val280Ala embC_p.Val280Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 11 0 11 3 11 9478 35694 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999691919899173 0.999448826618347 0.999846197812 0.214285714285714 0.0465792878898673 0.507975677048471 0 0 0.284914152918154 0 0 0.284914152918154 0 0 1.50082198019272 0.135452274385021 147 4975 False False 1.0270866504249 0.183946304787689 3.88915767329188 0 0 0.000389128685709026 0.999691919899173 0.999448826618347 0.999846197812 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 2 4 6558 26501 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999849085078287 0.999613643356053 0.999958879281354 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12290791020688 1 1103 4087 False False 0 0 0 0 0 0 0 2.02050930161634 0.182720640564327 14.1017085588021 0 0 0.00056234250533983 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Val337Ile embC_p.Val337Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Val34Ala embC_p.Val34Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Val34Met embC_p.Val34Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3837 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3173 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Val358Ala embC_p.Val358Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Val35Met embC_p.Val35Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 2 5 9479 35700 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999859963590533 0.999673232250017 0.999954529045718 0.285714285714285 0.0366925661760855 0.709579136262657 0 0 0.841886116991581 0 0 0.521823750104981 0 0 20.0619956863787 1 2818.5 4975 False False 1.50648802616309 0.143410178089837 9.20379905242336 0 0 0.000389087642036349 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 2 5 6558 26500 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999811356347858 0.999559824020536 0.9999387451734 0.285714285714285 0.0366925661760855 0.709579136262657 0 0 0.841886116991581 0 0 0.521823750104981 0 0 21.5222634684269 1 2276.5 4087 False False 0 0 0 0 0 0 0 1.61634644708752 0.15386320830351 9.87586276350829 0 0 0.00056234250533983 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Val363Asp embC_p.Val363Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3838 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3174 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Val363Ile embC_p.Val363Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Val371Ile embC_p.Val371Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3897 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Val388Ile embC_p.Val388Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Val417Met embC_p.Val417Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 0 0 0.602364635616474 0 0 0.4592581264399 0 0 5.70483372250837 0.585894740941386 369 4975 False False 0 0 3.19822685561766 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12104088004766 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 1 3) Uncertain significance No change no 1 +Ethambutol embC p.Val42Ala embC_p.Val42Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4065 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Val42Leu embC_p.Val42Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3854 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3188 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Val42Met embC_p.Val42Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3769 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3109 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Val469Met embC_p.Val469Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4002 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethambutol embC p.Val473Met embC_p.Val473Met 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4026 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3327 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Val482Ala embC_p.Val482Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Val506Ile embC_p.Val506Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3876 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3207 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Val52Ile embC_p.Val52Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Val548Met embC_p.Val548Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Val592Met embC_p.Val592Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Val608Leu embC_p.Val608Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 1 4 1 4 9480 35701 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999887970872426 0.999713186009257 0.999969475016731 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 0.941482067510548 0.0191153149568561 9.51304376083015 1 2818.5 4975 False False 0.941482067510548 0.0191153149568561 9.51304376083015 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 1 4 1 4 6559 26501 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999849085078287 0.999613643356053 0.999958879281354 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 1.01010062509528 0.0205075656450505 10.2127021503241 1 2276.5 4087 False False 0 0 0 0 0 0 0 1.01010062509528 0.0205075656450505 10.2127021503241 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Val625Ala embC_p.Val625Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3935 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3252 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Val625Leu embC_p.Val625Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Val626Met embC_p.Val626Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Val627Ile embC_p.Val627Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4014 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Val637Ile embC_p.Val637Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Val716Met embC_p.Val716Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3977 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3290 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Val755Leu embC_p.Val755Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4058 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3357 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Val757Ala embC_p.Val757Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 7 9481 35698 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 0 0 0.409616397225003 0 0 0.602364635616474 0 0 0.409616397225003 0 0 5.70467392400387 0.585892877153734 364 4975 False False 0 0 2.61285174975179 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 6 6560 26499 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 0 0 0.4592581264399 0 0 0.602364635616474 0 0 0.4592581264399 0 0 6.12057895719864 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 3.43165838346939 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Val769Met embC_p.Val769Met 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 0 9477 35705 0.000421896424427802 0.000114964157806894 0.00107986688593449 1 0.999896689850119 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 4035 4975 False False Inf 2.4863933079676 Inf 0 0 0.000389169738041761 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 0 6556 26505 0.000609756097560975 0.000166162208307701 0.00156047520083291 1 0.999860832946126 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3336 4087 False False 0 0 0 0 0 0 0 Inf 2.66797681781562 Inf 0 0 0.000562514007570737 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Val799Leu embC_p.Val799Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embC p.Val858Leu embC_p.Val858Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Val858Met embC_p.Val858Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Val885Met embC_p.Val885Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 2 6 9479 35699 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.99983195630864 0.999634275787128 0.999938328510354 0.25 0.0318540262499442 0.650855794412824 0 0 0.707598226178713 0 0 0.4592581264399 0 0 9.11668697482785 1 2818.5 4975 False False 1.25537152301578 0.123863858669135 7.02323716133577 0 0 0.000389087642036349 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3104 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Val920Ile embC_p.Val920Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 2 3 9479 35702 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.99991597815432 0.999754472342108 0.99998267234027 0.4 0.0527449505263169 0.853367200365326 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11745289828119 1 1480 4975 False False 2.51095403875232 0.209684820120099 21.9222407664312 0 0 0.000389087642036349 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 3 6559 26502 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999886813808715 0.999669257903365 0.999976657677988 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.78133043653875 1 2276.5 4087 False False 0 0 0 0 0 0 0 1.34685165421558 0.025651688752077 16.7753654027497 0 0 0.000562256793434776 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Val943Ile embC_p.Val943Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Val946Ile embC_p.Val946Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Val974Ala embC_p.Val974Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4027 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3328 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Val974Leu embC_p.Val974Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 14 0 14 7 15 9474 35690 0.000738318742748655 0.00029689231210758 0.00152062336565454 0.9995798907716 0.999307188228015 0.999764849596654 0.318181818181818 0.138646521553797 0.54872442757377 0 0 0.231635761650116 0 0 0.218019360910534 0 0 1.1359172026519 0.0521148008780118 98 4975 False False 1.75800436281753 0.606176620802685 4.58225401964346 0 0 0.000389292947027732 0.9995798907716 0.999307188228015 0.999764849596654 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 4 1 6556 26504 0.000609756097560975 0.000166162208307701 0.00156047520083291 0.999962271269571 0.999789807096406 0.999999044791703 0.8 0.28358206388191 0.994949236620532 0 0 0.975 0 0 0.975 0 0 157.28656201851 1 2276.5 4087 False False 0 0 0 0 0 0 0 16.1708358755338 1.59970034177407 792.771744020614 0 0 0.000562514007570737 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embC p.Val975Met embC_p.Val975Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embC p.Val981Leu embC_p.Val981Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1618 26 1592 842 5534 8639 30171 0.0888091973420525 0.0831573781653116 0.0947150829159004 0.84500770200252 0.841211879495072 0.848747316604999 0.132057716436637 0.123838972763416 0.140614591176522 0.0160692212608158 0.0105231039748901 0.0234570054041791 0.00467625899280575 0.00305689337202588 0.00684434685490353 0.057036979084565 0.0371136669735982 0.0839909438694576 3.24181528358902e-131 NA NA False True 0.53137261357491 0.491734953188994 0.573720795435946 0.003000577034045 0.00196098415625562 0.00439347112094602 0.84500770200252 0.841211879495072 0.848747316604999 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 1268 13 1255 516 4076 6044 22429 0.0786585365853658 0.0722562238513254 0.0854382976279419 0.84621769477457 0.841818025084591 0.850541320799247 0.112369337979094 0.103374516476835 0.12186032416387 0.0102523659305993 0.00546992807870192 0.0174680492117872 0.00317926143311323 0.00169387526630967 0.00543049771113404 0.0384401507141519 0.0203951527118445 0.0660585861593793 6.19312176279614e-106 NA NA False True 0 1 1 0 0 1 1 0.469786985722626 0.425978685101703 0.51727404533785 0.00214627703483572 0.00114328158035342 0.00366740257400698 0.84621769477457 0.841818025084591 0.850541320799247 520 Not assoc w R 5) Not assoc w R No change yes 1 +Ethambutol embC p.Val987Ala embC_p.Val987Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.10982832991351 0.590980565810755 492 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embR c.1011C>T embR_c.1011C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.1014C>T embR_c.1014C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.-101G>A embR_c.-101G>A 2 upstream_gene_variant 1417448 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embR c.1029C>T embR_c.1029C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.1033C>A embR_c.1033C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.1074C>T embR_c.1074C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.1077C>T embR_c.1077C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.1086G>A embR_c.1086G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.1087C>T embR_c.1087C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.108G>T embR_c.108G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.1095C>T embR_c.1095C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.1110C>T embR_c.1110C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.1122T>C embR_c.1122T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.1149G>A embR_c.1149G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.1149G>T embR_c.1149G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.1155T>C embR_c.1155T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.1158C>T embR_c.1158C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 7 9481 35698 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.61285174975179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.40943166615857 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.115C>T embR_c.115C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 8 9480 35697 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999775941744853 0.999558563909973 0.999903262744512 0.111111111111111 0.00280913674659921 0.482496514917337 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.47068829113924 0.010610026508271 3.51159115085171 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 6 6559 26499 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.99977362761743 0.99950734823901 0.999916920939814 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.673349595974996 0.0146401601947477 5.55241977196973 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.1167G>A embR_c.1167G>A 2 stop_retained_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.10982832991351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.117A>C embR_c.117A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.141C>T embR_c.141C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.144G>A embR_c.144G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 5 9477 35700 0.000421896424427802 0.000114964157806894 0.00107986688593449 0.999859963590533 0.999673232250017 0.999954529045718 0.444444444444444 0.136995662265166 0.787991493221131 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.01361190250079 0.597848979046568 13.9996935804854 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 4 5 6556 26500 0.000609756097560975 0.000166162208307701 0.00156047520083291 0.999811356347858 0.999559824020536 0.9999387451734 0.444444444444444 0.136995662265166 0.787991493221131 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.23367907260524 0.641440578643857 15.0221157142297 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.147C>T embR_c.147C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.-14A>G embR_c.-14A>G 2 upstream_gene_variant 1417361 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embR c.156C>A embR_c.156C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.15G>A embR_c.15G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.162C>G embR_c.162C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.171C>T embR_c.171C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.18A>C embR_c.18A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.19822685561766 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.198G>A embR_c.198G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.1A>T embR_c.1A>T 2 initiator_codon_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.225C>T embR_c.225C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.-22C>T embR_c.-22C>T 2 upstream_gene_variant 1417369 NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4903 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4029 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR c.249C>T embR_c.249C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.270A>G embR_c.270A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.76624472573839 0.0479745002090283 294.932792118969 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.276G>A embR_c.276G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.27G>A embR_c.27G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.282G>A embR_c.282G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.-28T>C embR_c.-28T>C 2 upstream_gene_variant 1417375 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR c.294G>A embR_c.294G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.88306962025316 0.0319145727646777 36.1783621216076 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.297G>A embR_c.297G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.88306962025316 0.0319145727646777 36.1783621216076 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.-2delC embR_c.-2delC 2 upstream_gene_variant 1417348 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4869 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4001 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embR c.309C>T embR_c.309C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.-31C>T embR_c.-31C>T 2 upstream_gene_variant 1417378 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR c.-33_-32insC embR_c.-33_-32insC 2 upstream_gene_variant 1417379 1 0 0 0 8 1 9473 35704 0.000843792848855605 0.000364358012393849 0.00166192766222289 0.999971992718106 0.999843963402622 0.999999290917266 0.888888888888888 0.517503485082663 0.9971908632534 NA NA NA 0 0 0.975 NA NA NA NA 4911 4975 False False 30.1522221049298 4.04116295283628 1328.54716994439 0 0 0.000389334034028122 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 8 1 6552 26504 0.00121951219512195 0.000526641184096925 0.00240150352406598 0.999962271269571 0.999789807096406 0.999999044791703 0.888888888888888 0.517503485082663 0.9971908632534 NA NA NA 0 0 0.975 NA NA NA NA 4037 4087 False False 0 0 0 0 0 0 0 32.3614163614163 4.33671337572761 1425.06187007021 0 0 0.000562857326050777 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR c.333T>C embR_c.333T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.334C>T embR_c.334C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.366C>T embR_c.366C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.369G>A embR_c.369G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.375G>A embR_c.375G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.-3G>A embR_c.-3G>A 2 upstream_gene_variant 1417350 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embR c.-3G>C embR_c.-3G>C 2 upstream_gene_variant 1417350 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR c.408C>T embR_c.408C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.-40C>G embR_c.-40C>G 2 upstream_gene_variant 1417387 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR c.-40C>T embR_c.-40C>T 2 upstream_gene_variant 1417387 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4971 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4083 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR c.411C>T embR_c.411C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.414G>A embR_c.414G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 9 9481 35696 0 0 0.00038900558066021 0.99974793446296 0.999521555266748 0.999884733314884 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.90786321657339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 6 6560 26499 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.43165838346939 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.414G>C embR_c.414G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 5 5 9476 35700 0.000527370530534753 0.000171257241502832 0.00123027414547083 0.999859963590533 0.999673232250017 0.999954529045718 0.5 0.187086028447398 0.812913971552601 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.7674124102997 0.866815029288652 16.380547623516 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 5 4 6555 26501 0.000762195121951219 0.000247527523788107 0.00177780526826415 0.999849085078287 0.999613643356053 0.999958879281354 0.555555555555555 0.212008506778868 0.863004337734833 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 5.05358504958047 1.08735642260634 25.4630909640805 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.420C>G embR_c.420C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.423A>C embR_c.423A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 9 9481 35696 0 0 0.00038900558066021 0.99974793446296 0.999521555266748 0.999884733314884 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.90786321657339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.-42C>T embR_c.-42C>T 2 upstream_gene_variant 1417389 1 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 157.21479794295 1 1103 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR c.-43A>G embR_c.-43A>G 2 upstream_gene_variant 1417390 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4875 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4006 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR c.441G>T embR_c.441G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.450C>T embR_c.450C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 12 9481 35693 0 0 0.00038900558066021 0.99966391261728 0.999412996653316 0.999826327071809 0 0 0.264648469397051 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.35519147325258 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 12 6560 26493 0 0 0.000562171107654053 0.999547255234861 0.999209279704825 0.999766038988972 0 0 0.264648469397051 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.45386850159099 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.456C>T embR_c.456C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.468C>T embR_c.468C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.471G>A embR_c.471G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.474C>T embR_c.474C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.477C>T embR_c.477C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.-48G>A embR_c.-48G>A 2 upstream_gene_variant 1417395 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embR c.-48G>C embR_c.-48G>C 2 upstream_gene_variant 1417395 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR c.492G>A embR_c.492G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.495G>A embR_c.495G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.498G>A embR_c.498G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.88306962025316 0.0319145727646777 36.1783621216076 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.-4C>A embR_c.-4C>A 2 upstream_gene_variant 1417351 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embR c.-501_-8del embR_c.-501_-8del 2 upstream_gene_variant 1417354 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR c.507C>T embR_c.507C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.-50T>C embR_c.-50T>C 2 upstream_gene_variant 1417397 1 1 0 1 3 2 9478 35703 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999943985436213 0.999797670939776 0.99999321630447 0.6 0.146632799634673 0.947255049473683 0 0 0.975 0 0 0.841886116991581 0 0 146.580348245845 1 1480 4975 False False 5.65040092846592 0.647137685918782 67.7491623796885 0 0 0.000389128685709026 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 1 6558 26504 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999962271269571 0.999789807096406 0.999999044791703 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 4078 4087 False False 0 0 0 0 0 0 0 8.08295211954864 0.420719628662148 475.373667785977 0 0 0.00056234250533983 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embR c.519C>G embR_c.519C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.528C>T embR_c.528C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.-52G>A embR_c.-52G>A 2 upstream_gene_variant 1417399 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4879 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4010 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR c.534G>A embR_c.534G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 9 93 9472 35612 0.000949266954962556 0.000434154257137837 0.00180123610483098 0.997395322783923 0.996810030146929 0.997897190284476 0.088235294117647 0.0411438313777185 0.160898192256286 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.363843177855274 0.161268375138304 0.721296337322859 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 6 70 6554 26435 0.000914634146341463 0.000335726224038477 0.00198970246660848 0.997358988870024 0.996664402560318 0.997940641283747 0.0789473684210526 0.0295237836690687 0.163955904880769 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 0 0.345721260734992 0.122653402022993 0.791493552223705 NA NA NA NA NA NA 41 5) Not assoc w R Now listed Silent mutation no 0 +Ethambutol embR c.537G>A embR_c.537G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.54A>G embR_c.54A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.-56G>A embR_c.-56G>A 2 upstream_gene_variant 1417403 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4907 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4033 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embR c.-56G>C embR_c.-56G>C 2 upstream_gene_variant 1417403 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR c.582C>T embR_c.582C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 8 9481 35697 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.20624116275339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 7 6560 26498 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.80327602229365 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.588T>A embR_c.588T>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.589C>T embR_c.589C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.-58A>C embR_c.-58A>C 2 upstream_gene_variant 1417405 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR c.591G>A embR_c.591G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.10982832991351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.-59A>G embR_c.-59A>G 2 upstream_gene_variant 1417406 1 3 0 3 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.11527461591697 1 2818.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.77947080093164 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol embR c.-5C>G embR_c.-5C>G 2 upstream_gene_variant 1417352 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR c.-61A>G embR_c.-61A>G 2 upstream_gene_variant 1417408 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR c.633G>A embR_c.633G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.642C>T embR_c.642C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.88306962025316 0.0319145727646777 36.1783621216076 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.645C>T embR_c.645C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.648C>T embR_c.648C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.654C>G embR_c.654C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.669T>C embR_c.669T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.672G>A embR_c.672G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.19822685561766 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.678C>T embR_c.678C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.-68T>C embR_c.-68T>C 2 upstream_gene_variant 1417415 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR c.690G>A embR_c.690G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.693G>A embR_c.693G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.-69G>A embR_c.-69G>A 2 upstream_gene_variant 1417416 1 5 0 5 2 9 9479 35696 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.99974793446296 0.999521555266748 0.999884733314884 0.181818181818181 0.0228311982999596 0.517755852360172 0 0 0.521823750104981 0 0 0.336267116879942 0 0 4.11023502412436 0.590978575917428 470 4975 False False 0.836844017770275 0.0879719531671099 4.04425008799206 0 0 0.000389087642036349 0.99974793446296 0.999521555266748 0.999884733314884 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 2 8 6558 26497 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999698170156574 0.999405361976814 0.999869682578628 0.2 0.0252107263268333 0.556095462307641 0 0 0.521823750104981 0 0 0.369416647552819 0 0 4.41027737114179 0.590385980131897 296 4087 False False 0 0 0 0 0 0 0 1.01010216529429 0.104463368269269 5.06308595441747 0 0 0.00056234250533983 0.999698170156574 0.999405361976814 0.999869682578628 1 3) Uncertain significance No change no 1 +Ethambutol embR c.714C>T embR_c.714C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.717C>A embR_c.717C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.735G>A embR_c.735G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.744C>T embR_c.744C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.-76G>A embR_c.-76G>A 2 upstream_gene_variant 1417423 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR c.774A>G embR_c.774A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 3 9480 35702 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99991597815432 0.999754472342108 0.99998267234027 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.25534458509142 0.0239099774609589 15.6346568618898 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 3 6559 26502 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999886813808715 0.999669257903365 0.999976657677988 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.34685165421558 0.025651688752077 16.7753654027497 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.78C>T embR_c.78C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.798C>T embR_c.798C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.804C>T embR_c.804C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 3 9480 35702 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99991597815432 0.999754472342108 0.99998267234027 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.25534458509142 0.0239099774609589 15.6346568618898 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 3 6559 26502 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999886813808715 0.999669257903365 0.999976657677988 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.34685165421558 0.025651688752077 16.7753654027497 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.825G>C embR_c.825G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.828G>A embR_c.828G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.-82G>A embR_c.-82G>A 2 upstream_gene_variant 1417429 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR c.843C>T embR_c.843C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.852G>A embR_c.852G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.867G>A embR_c.867G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.867G>C embR_c.867G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.888C>T embR_c.888C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.891G>A embR_c.891G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.894T>G embR_c.894T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.897C>A embR_c.897C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.-8G>C embR_c.-8G>C 2 upstream_gene_variant 1417355 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR c.900C>T embR_c.900C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.906A>C embR_c.906A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.907C>T embR_c.907C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.90G>A embR_c.90G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 3 9480 35702 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99991597815432 0.999754472342108 0.99998267234027 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.25534458509142 0.0239099774609589 15.6346568618898 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.90G>C embR_c.90G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.912A>G embR_c.912A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.10982832991351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.40943166615857 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.921G>A embR_c.921G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.937C>T embR_c.937C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.939G>C embR_c.939G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 7 9481 35698 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.61285174975179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 7 6560 26498 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.80327602229365 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.-93G>A embR_c.-93G>A 2 upstream_gene_variant 1417440 1 0 0 0 2 4 9479 35701 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999887970872426 0.999713186009257 0.999969475016731 0.333333333333333 0.0432718682927417 0.777221904496487 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4880 4975 False False 1.88316278088405 0.170308362439121 13.1422755166224 0 0 0.000389087642036349 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embR c.948C>T embR_c.948C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.-94T>C embR_c.-94T>C 2 upstream_gene_variant 1417441 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embR c.957C>T embR_c.957C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.963C>T embR_c.963C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 7 9481 35698 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.61285174975179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 6 6560 26499 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.43165838346939 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.972C>T embR_c.972C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.981C>T embR_c.981C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.99C>A embR_c.99C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR c.-99G>A embR_c.-99G>A 2 upstream_gene_variant 1417446 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR c.9T>C embR_c.9T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol embR deletion embR_deletion 2 feature_ablation (see "Genomic_coordinates" sheet) NA 0 0 0 0 7 9481 35698 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 4960 4975 False False 0 0 2.61285174975179 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4073 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 1 3) Uncertain significance New Uncertain no 0 +Ethambutol embR LoF embR_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 70 0 70 13 119 9468 35586 0.00137116337939035 0.000730282374626527 0.00234358976784705 0.996667133454698 0.996013036017744 0.997238244837331 0.0984848484848484 0.0534887053396234 0.162523364454865 0 0 0.0513337971510237 0 0 0.0305234448537962 0 0 0.203458897175276 1.39177100478352e-07 17 4975 True False 0.410598459916285 0.212307436734484 0.72982141100938 0 0 0.000389539599191658 0.996667133454698 0.996013036017744 0.997238244837331 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 53 0 53 10 83 6550 26422 0.00152439024390243 0.000731238785140689 0.00280161526425175 0.996868515374457 0.996119511022965 0.997505041525711 0.10752688172043 0.0527821990757087 0.188867574668422 0 0 0.0672345463063011 0 0 0.0434711521664418 0 0 0.290883327490428 1.47633737103092e-05 19 4087 True False 0 0 0 0 0 0 0 0.486011220454336 0.224661890453287 0.939976544926796 0 0 0.000563029142491623 0.996868515374457 0.996119511022965 0.997505041525711 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Ala117Thr embR_p.Ala117Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Ala121Glu embR_p.Ala121Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Ala121Thr embR_p.Ala121Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Ala121Val embR_p.Ala121Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4034 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 2 3) Uncertain significance No change no 1 +Ethambutol embR p.Ala125Thr embR_p.Ala125Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Ala126Val embR_p.Ala126Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4904 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4030 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Ala127Asp embR_p.Ala127Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.10982832991351 0.590980565810755 492 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12104088004766 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Ala127Val embR_p.Ala127Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 5 9480 35700 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999859963590533 0.999673232250017 0.999954529045718 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.975 0 0 0.521823750104981 0 0 146.537209422986 1 2818.5 4975 False False 0.753164556962025 0.0159260191955521 6.73154939272228 0 0 0.00038904660702099 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 3 6559 26502 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999886813808715 0.999669257903365 0.999976657677988 0.25 0.00630946320970987 0.805879550316756 0 0 0.975 0 0 0.707598226178713 0 0 157.202964052604 1 2276.5 4087 False False 0 0 0 0 0 0 0 1.34685165421558 0.025651688752077 16.7753654027497 0 0 0.000562256793434776 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Ala128Pro embR_p.Ala128Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 3 8 9478 35697 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999775941744853 0.999558563909973 0.999903262744512 0.272727272727272 0.0602177341729066 0.609742559572421 0 0 0.602364635616474 0 0 0.369416647552819 0 0 5.70631994168201 0.585912075504921 453 4975 False False 1.41236284026165 0.241278697490708 5.88592307150449 0 0 0.000389128685709026 0.999775941744853 0.999558563909973 0.999903262744512 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 3 7 6557 26498 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 0.999735898887002 0.999455926960675 0.999893811273379 0.3 0.0667395111777345 0.652452850059997 0 0 0.707598226178713 0 0 0.409616397225003 0 0 9.78283709376198 1 2276.5 4087 False False 0 0 0 0 0 0 0 1.73193315758513 0.288910719135753 7.58884844433105 0 0 0.000562428243381166 0.999735898887002 0.999455926960675 0.999893811273379 2 3) Uncertain significance No change no 1 +Ethambutol embR p.Ala134Thr embR_p.Ala134Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4941 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4059 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Ala141Val embR_p.Ala141Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 9479 35704 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999971992718106 0.999843963402622 0.999999290917266 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 146.569015564619 1 2818.5 4975 False False 7.53328410169849 0.392120325718966 443.147628387906 0 0 0.000389087642036349 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 6558 26504 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999962271269571 0.999789807096406 0.999999044791703 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 157.238712024072 1 1103 4087 False False 0 0 0 0 0 0 0 8.08295211954864 0.420719628662148 475.373667785977 0 0 0.00056234250533983 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Ala165_Ter389del embR_p.Ala165_Ter389del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Ala165Thr embR_p.Ala165Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Ala176Gly embR_p.Ala176Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 4 9480 35701 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999887970872426 0.999713186009257 0.999969475016731 0.2 0.00505076337946806 0.716417936118089 0 0 0.841886116991581 0 0 0.602364635616474 0 0 20.0604454397456 1 2818.5 4975 False False 0.941482067510548 0.0191153149568561 9.51304376083015 0 0 0.00038904660702099 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 3 6559 26502 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999886813808715 0.999669257903365 0.999976657677988 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 21.5206089807014 1 2276.5 4087 False False 0 0 0 0 0 0 0 1.34685165421558 0.025651688752077 16.7753654027497 0 0 0.000562256793434776 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Ala176Thr embR_p.Ala176Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Ala178Glu embR_p.Ala178Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4916 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4039 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Ala178Thr embR_p.Ala178Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Ala178Val embR_p.Ala178Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Ala180Asp embR_p.Ala180Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4896 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Ala183Val embR_p.Ala183Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4942 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethambutol embR p.Ala187Pro embR_p.Ala187Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Ala214Val embR_p.Ala214Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Ala283Gly embR_p.Ala283Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Ala290Val embR_p.Ala290Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4888 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Ala296Thr embR_p.Ala296Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.058895521352 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 21.5173342675905 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 3 3) Uncertain significance No change no 1 +Ethambutol embR p.Ala2Thr embR_p.Ala2Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4954 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4071 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Ala306Thr embR_p.Ala306Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 146.529978407112 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3999 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Ala330Val embR_p.Ala330Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4932 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Ala37Thr embR_p.Ala37Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Ala37Val embR_p.Ala37Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Ala382Thr embR_p.Ala382Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Ala40Thr embR_p.Ala40Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Ala58Asp embR_p.Ala58Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4972 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4084 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Ala5fs embR_p.Ala5fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4889 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4017 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Ala5Val embR_p.Ala5Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Ala68Thr embR_p.Ala68Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Ala70Ser embR_p.Ala70Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 5 152 9476 35553 0.000527370530534753 0.000171257241502832 0.00123027414547083 0.995742893152219 0.995011598551876 0.996391634978214 0.0318471337579617 0.0104199915268965 0.0727531810220668 NA NA NA 0 0 0.0239768209037916 NA NA NA NA NA NA False True 0.12341774788385 0.0394966969424837 0.294511007056813 0 0 0.000389210799037296 0.995742893152219 0.995011598551876 0.996391634978214 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 3 120 6557 26385 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 0.995472552348613 0.994588683327434 0.996244912620376 0.024390243902439 0.00505837721781325 0.06962452647985 NA NA NA 0 0 0.0302729725774201 NA NA NA NA NA NA False True 1 1 1 0 0 1 0 0.100598596919322 0.0204418932127114 0.301307296659455 0 0 0.000562428243381166 0.995472552348613 0.994588683327434 0.996244912620376 11 Not assoc w R 5) Not assoc w R No change yes 1 +Ethambutol embR p.Ala70Thr embR_p.Ala70Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 41 1 40 5 51 9476 35654 0.000527370530534753 0.000171257241502832 0.00123027414547083 0.998571628623442 0.998122377764315 0.99893630448237 0.0892857142857142 0.0296298418895422 0.196193440934782 0.024390243902439 0.000617316893286519 0.128554020384146 0.0192307692307692 0.000486762415492083 0.102553544652117 0.0940639510341916 0.0023278166817706 0.555205637043224 0.00156189205145405 33 4975 False False 0.368878239349771 0.114861100302989 0.918752637724913 0.000105518624037142 2.6714966936852e-06 0.000587770361337447 0.998571628623442 0.998122377764315 0.99893630448237 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 38 1 37 5 47 6555 26458 0.000762195121951219 0.000247527523788107 0.00177780526826415 0.998226749669873 0.997642642624476 0.99869680036167 0.0961538461538461 0.0319642363769216 0.210297471939325 0.0263157894736842 0.000666036204202366 0.13809902979242 0.0208333333333333 0.00052731525342312 0.110696160593152 0.109089409775908 0.0026935771918883 0.647000486588174 0.00374078720094731 34 4087 False False 0 0 0 0 0 0 0 0.429394485288151 0.133227405706474 1.07550360419856 0.000152532031726662 3.86176923405925e-06 0.000849557834692023 0.998226749669873 0.997642642624476 0.99869680036167 3 3) Uncertain significance No change no 1 +Ethambutol embR p.Ala86Gly embR_p.Ala86Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Ala86Thr embR_p.Ala86Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Ala95Gly embR_p.Ala95Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4890 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4018 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Ala95Thr embR_p.Ala95Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4933 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4050 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Ala96Thr embR_p.Ala96Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Arg102Pro embR_p.Arg102Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Arg10Gln embR_p.Arg10Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Arg10Trp embR_p.Arg10Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4928 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Arg130Gln embR_p.Arg130Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Arg130Trp embR_p.Arg130Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.10982832991351 0.590980565810755 492 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.40943166615857 0.590385352956204 278 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Arg136His embR_p.Arg136His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4944 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4061 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Arg204Pro embR_p.Arg204Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Arg204Trp embR_p.Arg204Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4917 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Arg220Trp embR_p.Arg220Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Arg229His embR_p.Arg229His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 146.529978407112 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 157.179059039538 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Arg248Cys embR_p.Arg248Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Arg309fs embR_p.Arg309fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Arg327Ser embR_p.Arg327Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4924 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethambutol embR p.Arg46Cys embR_p.Arg46Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4881 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4011 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Arg46His embR_p.Arg46His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4893 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4020 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Arg80fs embR_p.Arg80fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4912 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4038 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Asn342Lys embR_p.Asn342Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0615661524565 1 2818.5 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.5214194708504 1 2276.5 4087 False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 0 0 0.000562256793434776 0.999924542539143 0.999727448570663 0.999990861620785 3 3) Uncertain significance No change no 1 +Ethambutol embR p.Asn348Asp embR_p.Asn348Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Asn348fs embR_p.Asn348fs 2 frameshift (see "Genomic_coordinates" sheet) 1 23 0 23 1 28 9480 35677 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999215796106988 0.998866804929334 0.999478840936165 0.0344827586206896 0.000872646883579922 0.177644295488722 0 0 0.148185128915224 0 0 0.123436118500263 0 0 0.654856367499895 0.00814919684500308 52 4975 False False 0.134407022302591 0.00329043868362311 0.813205666787705 0 0 0.00038904660702099 0.999215796106988 0.998866804929334 0.999478840936165 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 14 0 14 1 16 6559 26489 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999396340313148 0.99901987910474 0.999654918214049 0.0588235294117647 0.00148817439126663 0.28688939666722 0 0 0.231635761650116 0 0 0.205907214207822 0 0 1.21789041661382 0.0874855013216972 88 4087 False False 0 0 0 0 0 0 0 0.25241080957463 0.0060216847241531 1.62536129194261 0 0 0.000562256793434776 0.999396340313148 0.99901987910474 0.999654918214049 1 3) Uncertain significance No change no 1 +Ethambutol embR p.Asn348Ser embR_p.Asn348Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4870 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Asn348Thr embR_p.Asn348Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Asn364His embR_p.Asn364His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Asn45Tyr embR_p.Asn45Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Asp107Asn embR_p.Asp107Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 8 11 9473 35694 0.000843792848855605 0.000364358012393849 0.00166192766222289 0.999691919899173 0.999448826618347 0.999846197812 0.421052631578947 0.202521438977162 0.665002155988264 0 0 0.369416647552819 0 0 0.284914152918154 0 0 2.20784597271871 0.217748017223951 238 4975 False False 2.74034336823316 0.956570727353967 7.48342673373093 0 0 0.000389334034028122 0.999691919899173 0.999448826618347 0.999846197812 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 4 6557 26501 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 0.999849085078287 0.999613643356053 0.999958879281354 0.428571428571428 0.0989882784425078 0.815948432359917 0 0 0.975 0 0 0.602364635616474 0 0 157.244877156611 1 2276.5 4087 False False 0 0 0 0 0 0 0 3.0312261705048 0.443920296646785 17.9196364560967 0 0 0.000562428243381166 0.999849085078287 0.999613643356053 0.999958879281354 9 3) Uncertain significance No change no 1 +Ethambutol embR p.Asp111Gly embR_p.Asp111Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Asp151Ala embR_p.Asp151Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Asp152_Thr164del embR_p.Asp152_Thr164del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Asp155Asn embR_p.Asp155Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4925 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4045 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Asp155Glu embR_p.Asp155Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Asp169Gly embR_p.Asp169Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4871 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4002 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Asp219Glu embR_p.Asp219Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Asp219Gly embR_p.Asp219Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 9479 35704 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999971992718106 0.999843963402622 0.999999290917266 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 146.569015564619 1 2818.5 4975 False False 7.53328410169849 0.392120325718966 443.147628387906 0 0 0.000389087642036349 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 6558 26504 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999962271269571 0.999789807096406 0.999999044791703 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 157.238712024072 1 1103 4087 False False 0 0 0 0 0 0 0 8.08295211954864 0.420719628662148 475.373667785977 0 0 0.00056234250533983 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Asp223Gly embR_p.Asp223Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Asp242Asn embR_p.Asp242Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Asp242Glu embR_p.Asp242Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Asp242Tyr embR_p.Asp242Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Asp24Asn embR_p.Asp24Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Asp24Tyr embR_p.Asp24Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 7 9481 35698 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 0 0 0.409616397225003 0 0 0.521823750104981 0 0 0.409616397225003 0 0 4.10959809458789 0.590981691334869 521.5 4975 False False 0 0 2.61285174975179 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 6.12080991862283 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Asp261fs embR_p.Asp261fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Asp278Gly embR_p.Asp278Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Asp294Asn embR_p.Asp294Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 4 9479 35701 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999887970872426 0.999713186009257 0.999969475016731 0.333333333333333 0.0432718682927417 0.777221904496487 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4961 4975 False False 1.88316278088405 0.170308362439121 13.1422755166224 0 0 0.000389087642036349 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 4 6558 26501 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999849085078287 0.999613643356053 0.999958879281354 0.333333333333333 0.0432718682927417 0.777221904496487 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4074 4087 False False 0 0 0 0 0 0 0 2.02050930161634 0.182720640564327 14.1017085588021 0 0 0.00056234250533983 0.999849085078287 0.999613643356053 0.999958879281354 1 3) Uncertain significance No change no 1 +Ethambutol embR p.Asp294Tyr embR_p.Asp294Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4867 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Asp315Ala embR_p.Asp315Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4872 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4003 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Asp317Asn embR_p.Asp317Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4968 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4080 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Asp317Glu embR_p.Asp317Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Asp334Glu embR_p.Asp334Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4908 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Asp365Ala embR_p.Asp365Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4918 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4040 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Asp89Asn embR_p.Asp89Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Cys110Tyr embR_p.Cys110Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 304 3525 9177 32180 0.032064128256513 0.0286096454574935 0.0358098550044959 0.901274331326144 0.89813356189061 0.904349657657677 0.0793940976756333 0.0710237924790286 0.0884127791119395 NA NA NA 0 0 0.0010459432449256 NA NA NA NA NA NA False True 0.302412522209006 0.267482372706677 0.340921242997012 0 0 0.000401889304114066 0.901274331326144 0.89813356189061 0.904349657657677 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 222 2931 6338 23574 0.0338414634146341 0.0295978680281229 0.0385057222501187 0.889417091114884 0.885579899932737 0.89316867698014 0.0704091341579448 0.0617224100022008 0.0799025735110003 NA NA NA 0 0 0.00125778200763661 NA NA NA NA NA NA False True 1 1 1 0 0 1 1 0.281720337726691 0.243999751735737 0.323971550952829 0 0 0.000581856445387454 0.889417091114884 0.885579899932737 0.89316867698014 637 Not assoc w R 5) Not assoc w R No change yes 1 +Ethambutol embR p.Cys184Arg embR_p.Cys184Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4955 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4072 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Cys372Arg embR_p.Cys372Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Cys372Gly embR_p.Cys372Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 9 9481 35696 0 0 0.00038900558066021 0.99974793446296 0.999521555266748 0.999884733314884 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 4882 4975 False True 0 0 1.90786321657339 0 0 0.00038900558066021 0.99974793446296 0.999521555266748 0.999884733314884 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4012 4087 False True 0 1 1 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 442 5) Not assoc w R New NotAwR yes 5 +Ethambutol embR p.Gln20Pro embR_p.Gln20Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Gln20* embR_p.Gln20* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4962 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4075 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Gln257His embR_p.Gln257His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Gln258Pro embR_p.Gln258Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Gln286His embR_p.Gln286His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Gln287* embR_p.Gln287* 2 stop_gained (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Gln353Arg embR_p.Gln353Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 13 9481 35692 0 0 0.00038900558066021 0.999635905335387 0.999377467513205 0.999806121137399 0 0 0.24705263800047 0 0 0.975 0 0 0.24705263800047 0 0 146.489030983299 1 2818.5 4975 False False 0 0 1.2354962611609 0 0 0.00038900558066021 0.999635905335387 0.999377467513205 0.999806121137399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 13 6560 26492 0 0 0.000562171107654053 0.999509526504433 0.999161421428146 0.999738818498366 0 0 0.24705263800047 0 0 0.975 0 0 0.24705263800047 0 0 157.119898497449 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 1.32548813951656 0 0 0.000562171107654053 0.999509526504433 0.999161421428146 0.999738818498366 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Gln353Pro embR_p.Gln353Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 4973 4975 False False 0 0 3.19822685561766 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 6560 26499 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 4085 4087 False False 0 0 0 0 0 0 0 0 0 3.43165838346939 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 2 3) Uncertain significance No change no 1 +Ethambutol embR p.Gln353* embR_p.Gln353* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4926 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4046 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Gln379Arg embR_p.Gln379Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.10982832991351 0.590980565810755 492 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12104088004766 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 1 3) Uncertain significance No change no 1 +Ethambutol embR p.Glu118Gly embR_p.Glu118Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Glu118Lys embR_p.Glu118Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Glu132* embR_p.Glu132* 2 stop_gained (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Glu144fs embR_p.Glu144fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Glu144Gln embR_p.Glu144Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Glu144Gly embR_p.Glu144Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Glu160fs embR_p.Glu160fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Glu195fs embR_p.Glu195fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Glu200Asp embR_p.Glu200Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4913 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Glu61fs embR_p.Glu61fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Glu61Gly embR_p.Glu61Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4909 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4035 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Glu62Ala embR_p.Glu62Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Glu62del embR_p.Glu62del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 9479 35704 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999971992718106 0.999843963402622 0.999999290917266 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 146.569015564619 1 2818.5 4975 False False 7.53328410169849 0.392120325718966 443.147628387906 0 0 0.000389087642036349 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 6558 26504 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999962271269571 0.999789807096406 0.999999044791703 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 157.238712024072 1 1103 4087 False False 0 0 0 0 0 0 0 8.08295211954864 0.420719628662148 475.373667785977 0 0 0.00056234250533983 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embR p.Glu8fs embR_p.Glu8fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Gly100Asp embR_p.Gly100Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embR p.Gly100Val embR_p.Gly100Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Gly122Ser embR_p.Gly122Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embR p.Gly129Asp embR_p.Gly129Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Gly129Cys embR_p.Gly129Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4948 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4064 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Gly129Ser embR_p.Gly129Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Gly147Arg embR_p.Gly147Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Gly17Glu embR_p.Gly17Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 1 3) Uncertain significance No change no 1 +Ethambutol embR p.Gly185Arg embR_p.Gly185Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4051 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 2 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Gly226fs embR_p.Gly226fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embR p.Gly244fs embR_p.Gly244fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Gly244Ser embR_p.Gly244Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4905 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4031 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Gly272_Val274del embR_p.Gly272_Val274del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Gly272Ser embR_p.Gly272Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4966 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4079 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Gly285fs embR_p.Gly285fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Gly285Ser embR_p.Gly285Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4929 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Gly300Cys embR_p.Gly300Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 10 9481 35695 0 0 0.00038900558066021 0.999719927181067 0.999484996631079 0.999865686288203 0 0 0.30849710781876 NA NA NA 0 0 0.30849710781876 NA NA NA NA 4949 4975 False False 0 0 1.67996531074212 0 0 0.00038900558066021 0.999719927181067 0.999484996631079 0.999865686288203 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 10 6560 26495 0 0 0.000562171107654053 0.999622712695717 0.999306265033238 0.999819061720012 0 0 0.30849710781876 NA NA NA 0 0 0.30849710781876 NA NA NA NA 4065 4087 False False 0 0 0 0 0 0 0 0 0 1.80248078294835 0 0 0.000562171107654053 0.999622712695717 0.999306265033238 0.999819061720012 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Gly311Arg embR_p.Gly311Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Gly336Ser embR_p.Gly336Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Gly349Asp embR_p.Gly349Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Gly383Glu embR_p.Gly383Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4919 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4041 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Gly387Asp embR_p.Gly387Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4877 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4008 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Gly3Asp embR_p.Gly3Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethambutol embR p.Gly3Val embR_p.Gly3Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Gly51Arg embR_p.Gly51Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 1 9479 35704 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999971992718106 0.999843963402622 0.999999290917266 0.666666666666666 0.0942993240502461 0.991596241340387 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0965702950467794 Inf 0.209808781869688 177.5 4975 False False 7.53328410169849 0.392120325718966 443.147628387906 0.00010548523206751 2.670651284468e-06 0.000587584402906152 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4066 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Gly51Glu embR_p.Gly51Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 1 9479 35704 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999971992718106 0.999843963402622 0.999999290917266 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 4897 4975 False False 7.53328410169849 0.392120325718966 443.147628387906 0 0 0.000389087642036349 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 1 6558 26504 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999962271269571 0.999789807096406 0.999999044791703 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 4023 4087 False False 0 0 0 0 0 0 0 8.08295211954864 0.420719628662148 475.373667785977 0 0 0.00056234250533983 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Gly67Asp embR_p.Gly67Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Gly67Val embR_p.Gly67Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4951 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4068 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Gly84fs embR_p.Gly84fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Gly84Ser embR_p.Gly84Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4906 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4032 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Gly85Asp embR_p.Gly85Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.His124_Ala125delinsPro embR_p.His124_Ala125delinsPro 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.His124Arg embR_p.His124Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4920 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4042 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.His137Gln embR_p.His137Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 9 9481 35696 0 0 0.00038900558066021 0.99974793446296 0.999521555266748 0.999884733314884 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 4883 4975 False False 0 0 1.90786321657339 0 0 0.00038900558066021 0.99974793446296 0.999521555266748 0.999884733314884 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 9 6560 26496 0 0 0.000562171107654053 0.999660441426146 0.999355510362951 0.999844720818052 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 4013 4087 False False 0 0 0 0 0 0 0 0 0 2.04691100627475 0 0 0.000562171107654053 0.999660441426146 0.999355510362951 0.999844720818052 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.His137Tyr embR_p.His137Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.058895521352 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 21.5173342675905 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 1 3) Uncertain significance No change no 1 +Ethambutol embR p.His174Tyr embR_p.His174Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.His293Arg embR_p.His293Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4963 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4076 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.His293Asp embR_p.His293Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Ile105Thr embR_p.Ile105Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4876 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4007 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Ile182Met embR_p.Ile182Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4873 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4004 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Ile212Val embR_p.Ile212Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Ile241_Gly244del embR_p.Ile241_Gly244del 2 inframe_deletion (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4943 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4060 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Ile318Val embR_p.Ile318Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Ile341Val embR_p.Ile341Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4950 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4067 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Ile44Val embR_p.Ile44Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Ile56Thr embR_p.Ile56Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Ile88Val embR_p.Ile88Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Leu103Arg embR_p.Leu103Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4898 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4024 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Leu103Pro embR_p.Leu103Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 3 3) Uncertain significance No change no 1 +Ethambutol embR p.Leu11Arg embR_p.Leu11Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Leu138Met embR_p.Leu138Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4894 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4021 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Leu142fs embR_p.Leu142fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Leu150Phe embR_p.Leu150Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Leu153Arg embR_p.Leu153Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Leu172Arg embR_p.Leu172Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4969 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4081 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Leu207Pro embR_p.Leu207Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4878 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4009 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Leu211Pro embR_p.Leu211Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Leu217Val embR_p.Leu217Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 85 7 78 52 117 9429 35588 0.00548465351756143 0.00409883411486123 0.00718624742976459 0.996723148018484 0.996074056717073 0.997289223300708 0.307692307692307 0.23909427676193 0.383179406574923 0.0823529411764705 0.0337525436178748 0.162343904723825 0.0564516129032258 0.0229949864229856 0.112854795377547 0.33872042335294 0.131797634893129 0.731837038230492 0.0029503368686026 36 4975 False False 1.67747257279551 1.18502643235101 2.34684621245371 0.000741839762611276 0.000298308421715733 0.00152787231987525 0.996723148018484 0.996074056717073 0.997289223300708 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 1 6 14 12 6546 26493 0.00213414634146341 0.0011672334829473 0.00357814496544914 0.999547255234861 0.999209279704825 0.999766038988972 0.538461538461538 0.333708218475292 0.734128782577048 0.142857142857142 0.00361029686190058 0.578723197043195 0.0769230769230769 0.00194562849734675 0.360297435267877 0.67453406660556 0.0146659016194699 5.5622047515086 1 1103 4087 False False 0 0 0 0 0 0 0 4.72173846623892 2.02589972511266 11.182063155725 0.000152741713762028 3.86707790305337e-06 0.000850725293240249 0.999547255234861 0.999209279704825 0.999766038988972 15 3) Uncertain significance No change no 1 +Ethambutol embR p.Leu239Val embR_p.Leu239Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 12 0 12 1 40 9480 35665 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.998879708724268 0.998474790382045 0.999199530618593 0.024390243902439 0.000617316893286519 0.128554020384146 0 0 0.264648469397051 0 0 0.0880973028788023 0 0 1.3542713218162 0.0835511135487906 107 4975 False False 0.094053270042194 0.00232755296993901 0.555142217123748 0 0 0.00038904660702099 0.998879708724268 0.998474790382045 0.999199530618593 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 1 35 6559 26470 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.998679494435012 0.998163970304167 0.999080052474596 0.0277777777777777 0.00070302520590478 0.145289264746853 0 0 0.30849710781876 0 0 0.100032435572105 0 0 1.80105677267611 0.227590644656015 180 4087 False False 0 0 0 0 0 0 0 0.115305033432796 0.00284259201502675 0.686302205062878 0 0 0.000562256793434776 0.998679494435012 0.998163970304167 0.999080052474596 1 3) Uncertain significance No change no 1 +Ethambutol embR p.Leu277Arg embR_p.Leu277Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4891 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Leu292Val embR_p.Leu292Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 20.058335224773 1 1480 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 21.5165239024995 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Leu303Arg embR_p.Leu303Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4930 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4048 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Leu313Arg embR_p.Leu313Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 75 39 9406 35666 0.0079105579580213 0.00622709294693484 0.00990599781850098 0.998907716006161 0.998507111173478 0.999223167585189 0.657894736842105 0.563182387216833 0.744179791031807 NA NA NA 0 0 0.0902511009603342 NA NA NA NA 4935 4975 False False 7.29199038257086 4.88534697863608 11.0373990924785 0 0 0.00039210676053106 0.998907716006161 0.998507111173478 0.999223167585189 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 60 38 6500 26467 0.00914634146341463 0.00698667297704131 0.0117576709883518 0.998566308243727 0.998032671713558 0.998985240811267 0.612244897959183 0.508486185098785 0.709028976466044 NA NA NA 0 0 0.0925127614158782 NA NA NA NA 4052 4087 False False 0 0 0 0 0 0 0 6.42923076923076 4.20835646306746 9.93066111423571 0 0 0.000567358907050029 0.998566308243727 0.998032671713558 0.998985240811267 4 3) Uncertain significance No change no 1 +Ethambutol embR p.Leu320Pro embR_p.Leu320Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Leu79fs embR_p.Leu79fs 2 frameshift (see "Genomic_coordinates" sheet) 1 5 0 5 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 4.10971321225031 0.590981128432313 516.5 4975 False False 0 0 3.19822685561766 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.77947080093164 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Leu83Phe embR_p.Leu83Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4964 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Lys170Thr embR_p.Lys170Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4952 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4069 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Lys177_Ala180del embR_p.Lys177_Ala180del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4868 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4000 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Lys263Glu embR_p.Lys263Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 9 0 9 0 10 9481 35695 0 0 0.00038900558066021 0.999719927181067 0.999484996631079 0.999865686288203 0 0 0.30849710781876 0 0 0.336267116879942 0 0 0.30849710781876 0 0 1.90780977028248 0.219223304182763 249 4975 False False 0 0 1.67996531074212 0 0 0.00038900558066021 0.999719927181067 0.999484996631079 0.999865686288203 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 0 10 6560 26495 0 0 0.000562171107654053 0.999622712695717 0.999306265033238 0.999819061720012 0 0 0.30849710781876 0 0 0.336267116879942 0 0 0.30849710781876 0 0 2.04683374325628 0.220130286309629 162 4087 False False 0 0 0 0 0 0 0 0 0 1.80248078294835 0 0 0.000562171107654053 0.999622712695717 0.999306265033238 0.999819061720012 1 3) Uncertain significance No change no 1 +Ethambutol embR p.Lys264Thr embR_p.Lys264Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Lys267Arg embR_p.Lys267Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 146.529978407112 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Lys81Glu embR_p.Lys81Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4901 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4027 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Met1? embR_p.Met1? 2 start_lost (see "Genomic_coordinates" sheet) 1 1 0 1 5 16 9476 35689 0.000527370530534753 0.000171257241502832 0.00123027414547083 0.999551883489707 0.999272388596077 0.99974384169233 0.238095238095238 0.0821758755930225 0.471659827654621 0 0 0.975 0 0 0.205907214207822 0 0 146.553858042375 1 2818.5 4975 False False 1.17695361967074 0.33711691591475 3.36338142214771 0 0 0.000389210799037296 0.999551883489707 0.999272388596077 0.99974384169233 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 4 10 6556 26495 0.000609756097560975 0.000166162208307701 0.00156047520083291 0.999622712695717 0.999306265033238 0.999819061720012 0.285714285714285 0.0838893183071275 0.581035257183661 0 0 0.975 0 0 0.30849710781876 0 0 157.233285229003 1 2276.5 4087 False False 0 0 0 0 0 0 0 1.61653447223917 0.369946863340775 5.60642581211926 0 0 0.000562514007570737 0.999622712695717 0.999306265033238 0.999819061720012 2 3) Uncertain significance New Uncertain no 1 +Ethambutol embR p.Met282Thr embR_p.Met282Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Met282Val embR_p.Met282Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Met41Ile embR_p.Met41Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4927 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4047 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Phe13Cys embR_p.Phe13Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4958 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Phe162Val embR_p.Phe162Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Phe376Leu embR_p.Phe376Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 8 9481 35697 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 4945 4975 False True 0 0 2.20624116275339 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4062 4087 False True 0 1 1 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 352 5) Not assoc w R New NotAwR yes 5 +Ethambutol embR p.Phe378Leu embR_p.Phe378Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4886 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4015 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embR p.Phe378Tyr embR_p.Phe378Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Pro18Arg embR_p.Pro18Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4938 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4055 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Pro302Leu embR_p.Pro302Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Pro49Arg embR_p.Pro49Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Pro90Leu embR_p.Pro90Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Ser104_Gly113delinsArg embR_p.Ser104_Gly113delinsArg 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4936 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4053 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Ser135Asn embR_p.Ser135Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Ser188Asn embR_p.Ser188Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Ser218Ala embR_p.Ser218Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.10982832991351 0.590980565810755 492 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.40943166615857 0.590385352956204 278 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Ser30Pro embR_p.Ser30Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4931 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4049 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Ser326Arg embR_p.Ser326Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Ser4Asn embR_p.Ser4Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Ser66Ala embR_p.Ser66Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 12 0 12 0 12 9481 35693 0 0 0.00038900558066021 0.99966391261728 0.999412996653316 0.999826327071809 0 0 0.264648469397051 0 0 0.264648469397051 0 0 0.264648469397051 0 0 1.35519147325258 0.0835905265175333 111 4975 False False 0 0 1.35519147325258 0 0 0.00038900558066021 0.99966391261728 0.999412996653316 0.999826327071809 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 0 11 0 11 6560 26494 0 0 0.000562171107654053 0.999584983965289 0.999257543293353 0.999792807866341 0 0 0.284914152918154 0 0 0.284914152918154 0 0 0.284914152918154 0 0 1.60965686204705 0.13661861299788 105 4087 False False 0 0 0 0 0 0 0 0 0 1.60965686204705 0 0 0.000562171107654053 0.999584983965289 0.999257543293353 0.999792807866341 1 3) Uncertain significance No change no 1 +Ethambutol embR p.Ser66fs embR_p.Ser66fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4914 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Ter389Serext*? embR_p.Ter389Serext*? 2 stop_lost (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Thr120fs embR_p.Thr120fs 2 frameshift (see "Genomic_coordinates" sheet) 1 16 0 16 5 20 9476 35685 0.000527370530534753 0.000171257241502832 0.00123027414547083 0.999439854362134 0.999135032404509 0.999657815983264 0.2 0.068311464012484 0.407037432278677 0 0 0.205907214207822 0 0 0.168433470983085 0 0 0.976701316507242 0.0325415267960323 77 4975 False False 0.941457365977205 0.27603251944769 2.58578295319993 0 0 0.000389210799037296 0.999439854362134 0.999135032404509 0.999657815983264 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 13 0 13 4 14 6556 26491 0.000609756097560975 0.000166162208307701 0.00156047520083291 0.999471797774004 0.999113925067086 0.999711197799087 0.222222222222222 0.0640920477176664 0.47637276573648 0 0 0.24705263800047 0 0 0.231635761650116 0 0 1.32624697598734 0.0853295469292879 87 4087 False False 0 0 0 0 0 0 0 1.15449315784886 0.276618600776596 3.67743283501464 0 0 0.000562514007570737 0.999471797774004 0.999113925067086 0.999711197799087 7 3) Uncertain significance No change no 1 +Ethambutol embR p.Thr164Ala embR_p.Thr164Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 9 1 8 11 10 9470 35695 0.00116021516717645 0.00057931301275248 0.00207499495108562 0.999719927181067 0.999484996631079 0.999865686288203 0.523809523809523 0.297806838783642 0.742869373593593 0.111111111111111 0.00280913674659921 0.482496514917337 0.0909090909090909 0.00229897221381426 0.412779916988382 0.471158922914466 0.0106206299111456 3.5151037419422 0.695157850168816 533 4975 False False 4.1461985216473 1.59798624124065 10.8892433882189 0.000105585471439129 2.67318911885021e-06 0.000588142631535891 0.999719927181067 0.999484996631079 0.999865686288203 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 157.21479794295 1 1103 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embR p.Thr164Arg embR_p.Thr164Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Thr175Asn embR_p.Thr175Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Thr198Ile embR_p.Thr198Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Thr213Ser embR_p.Thr213Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 12 0 12 0 13 9481 35692 0 0 0.00038900558066021 0.999635905335387 0.999377467513205 0.999806121137399 0 0 0.24705263800047 0 0 0.264648469397051 0 0 0.24705263800047 0 0 1.3551535085683 0.0835888959771131 108 4975 False False 0 0 1.2354962611609 0 0 0.00038900558066021 0.999635905335387 0.999377467513205 0.999806121137399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 0 11 0 12 6560 26493 0 0 0.000562171107654053 0.999547255234861 0.999209279704825 0.999766038988972 0 0 0.264648469397051 0 0 0.284914152918154 0 0 0.264648469397051 0 0 1.60959611461803 0.136617078895873 102.5 4087 False False 0 0 0 0 0 0 0 0 0 1.45386850159099 0 0 0.000562171107654053 0.999547255234861 0.999209279704825 0.999766038988972 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Thr233Pro embR_p.Thr233Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4884 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4014 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Thr246Ala embR_p.Thr246Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4956 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Thr246fs embR_p.Thr246fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4959 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Thr246Met embR_p.Thr246Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethambutol embR p.Thr268Ala embR_p.Thr268Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Thr268fs embR_p.Thr268fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance No change no 1 +Ethambutol embR p.Thr268Ile embR_p.Thr268Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 1 5 9480 35700 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999859963590533 0.999673232250017 0.999954529045718 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.11026191518576 0.590978447004432 468.5 4975 False False 0.753164556962025 0.0159260191955521 6.73154939272228 0 0 0.00038904660702099 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 1 5 6559 26500 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999811356347858 0.999559824020536 0.9999387451734 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.41010407429796 0.590385853468398 295 4087 False False 0 0 0 0 0 0 0 0.808050007623113 0.0170817619606711 7.22310074751644 0 0 0.000562256793434776 0.999811356347858 0.999559824020536 0.9999387451734 2 3) Uncertain significance No change no 1 +Ethambutol embR p.Thr269Ser embR_p.Thr269Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4921 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Thr26Ala embR_p.Thr26Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.19822685561766 0.354697857676227 290 4975 False False 0 0 3.19822685561766 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 6560 26499 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.43165838346939 0.605981932438924 311.5 4087 False False 0 0 0 0 0 0 0 0 0 3.43165838346939 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 1 3) Uncertain significance No change no 1 +Ethambutol embR p.Thr26Asn embR_p.Thr26Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4885 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Thr26Pro embR_p.Thr26Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 146.529978407112 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Thr26Ser embR_p.Thr26Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4946 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4063 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Thr275Ala embR_p.Thr275Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4922 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4043 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Thr308Pro embR_p.Thr308Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4915 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Thr335Ala embR_p.Thr335Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4923 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4044 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Thr335Met embR_p.Thr335Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4899 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4025 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Thr337Ile embR_p.Thr337Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Thr337Pro embR_p.Thr337Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4939 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4056 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Thr362Met embR_p.Thr362Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Thr384Arg embR_p.Thr384Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4937 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4054 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Thr384Met embR_p.Thr384Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Thr57Ala embR_p.Thr57Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 10 0 10 0 10 9481 35695 0 0 0.00038900558066021 0.999719927181067 0.999484996631079 0.999865686288203 0 0 0.30849710781876 0 0 0.30849710781876 0 0 0.30849710781876 0 0 1.67996531074212 0.134582133412278 140.5 4975 False False 0 0 1.67996531074212 0 0 0.00038900558066021 0.999719927181067 0.999484996631079 0.999865686288203 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 0 9 6560 26496 0 0 0.000562171107654053 0.999660441426146 0.999355510362951 0.999844720818052 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.336267116879942 0 0 2.04691100627475 0.2201316772645 166 4087 False False 0 0 0 0 0 0 0 0 0 2.04691100627475 0 0 0.000562171107654053 0.999660441426146 0.999355510362951 0.999844720818052 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Thr6fs embR_p.Thr6fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Trp145Arg embR_p.Trp145Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4910 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4036 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Trp145Ser embR_p.Trp145Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4934 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Trp208Cys embR_p.Trp208Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Trp208* embR_p.Trp208* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 0 0 0.975 0 0 0.4592581264399 0 0 146.517694185482 1 2818.5 4975 False False 0 0 3.19822685561766 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 4057 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Trp63* embR_p.Trp63* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Tyr203His embR_p.Tyr203His 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.058895521352 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 21.5173342675905 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Tyr203* embR_p.Tyr203* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4953 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4070 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Tyr215fs embR_p.Tyr215fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4892 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4019 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Tyr216fs embR_p.Tyr216fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4902 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4028 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Tyr216His embR_p.Tyr216His 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Tyr228His embR_p.Tyr228His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Tyr291Cys embR_p.Tyr291Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 3 1 9478 35704 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999971992718106 0.999843963402622 0.999999290917266 0.75 0.194120449683243 0.99369053679029 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 3.76703945980164 0.0479846225105715 294.994865238518 0.375566530700865 328.5 4975 False False 11.3011183794049 0.90722384791697 591.183089908516 0.000105496360375567 2.67093302808208e-06 0.000587646375974446 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 3 1 6557 26504 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 0.999962271269571 0.999789807096406 0.999999044791703 0.75 0.194120449683243 0.99369053679029 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 4.04209242031416 0.0514858593749597 316.476725160821 0.357359853770073 187 4087 False False 0 0 0 0 0 0 0 12.1262772609425 0.973374031902014 634.171386087929 0.000152485513876181 3.86059150860036e-06 0.000849298834468653 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embR p.Tyr291* embR_p.Tyr291* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Tyr301* embR_p.Tyr301* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4947 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Val123Ala embR_p.Val123Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Val123Met embR_p.Val123Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 1 9478 35704 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999971992718106 0.999843963402622 0.999999290917266 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 146.584444274952 1 1480 4975 False False 11.3011183794049 0.90722384791697 591.183089908516 0 0 0.000389128685709026 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Val149fs embR_p.Val149fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4967 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Val167Leu embR_p.Val167Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Val190Gly embR_p.Val190Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4974 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4086 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Val190Leu embR_p.Val190Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4957 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Val231Leu embR_p.Val231Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4895 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4022 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Val274Asp embR_p.Val274Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Val274Ile embR_p.Val274Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Val276Met embR_p.Val276Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.10982832991351 0.590980565810755 492 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12104088004766 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Val289Ala embR_p.Val289Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Val289Gly embR_p.Val289Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Val289Leu embR_p.Val289Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Val28Ala embR_p.Val28Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Val319Ala embR_p.Val319Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4965 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4077 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 1 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Val319Ile embR_p.Val319Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4970 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4082 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Val325Ile embR_p.Val325Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 8 9481 35697 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 4887 4975 False False 0 0 2.20624116275339 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 8 6560 26497 0 0 0.000562171107654053 0.999698170156574 0.999405361976814 0.999869682578628 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 4016 4087 False False 0 0 0 0 0 0 0 0 0 2.36695385477914 0 0 0.000562171107654053 0.999698170156574 0.999405361976814 0.999869682578628 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Val352Met embR_p.Val352Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Val38Met embR_p.Val38Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4940 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4058 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embR p.Val50del embR_p.Val50del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol embR p.Val50Ile embR_p.Val50Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.058895521352 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 21.5173342675905 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 2 3) Uncertain significance No change no 1 +Ethambutol embR p.Val50Leu embR_p.Val50Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4900 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4026 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol embR p.Val7Gly embR_p.Val7Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 0 0 0.602364635616474 0 0 0.4592581264399 0 0 5.70483372250837 0.585894740941386 369 4975 False False 0 0 3.19822685561766 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 6 6560 26499 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 0 0 0.4592581264399 0 0 0.602364635616474 0 0 0.4592581264399 0 0 6.12057895719864 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 3.43165838346939 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 1 3) Uncertain significance No change no 1 +Ethambutol embR p.Val92Met embR_p.Val92Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embR p.Val93_Leu94del embR_p.Val93_Leu94del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4874 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4005 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol embR p.Val93Met embR_p.Val93Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol glpK c.1011G>A glpK_c.1011G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.102C>T glpK_c.102C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1035G>A glpK_c.1035G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1045C>T glpK_c.1045C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1050C>T glpK_c.1050C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 5 0 9476 35705 0.000527370530534753 0.000171257241502832 0.00123027414547083 1 0.999896689850119 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 3.45192218064103 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 5 0 6555 26505 0.000762195121951219 0.000247527523788107 0.00177780526826415 1 0.999860832946126 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 3.70403509656001 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1062C>T glpK_c.1062C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1089G>A glpK_c.1089G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1102C>T glpK_c.1102C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 36 9479 35669 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.998991737851841 0.998604410736722 0.999293728778475 0.0526315789473684 0.00643871671509191 0.17749059034764 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.209052759902005 0.0243764336847722 0.812294361048075 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 16 6558 26489 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999396340313148 0.99901987910474 0.999654918214049 0.111111111111111 0.0137512156643644 0.347120438608672 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.504898597133272 0.0563088667021503 2.14853391102988 NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1104G>A glpK_c.1104G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1107C>T glpK_c.1107C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1113A>G glpK_c.1113A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1122G>A glpK_c.1122G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1134C>T glpK_c.1134C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 431 4267 9050 31438 0.0454593397320957 0.0413537781942906 0.0498469768654399 0.880492928161322 0.877083266974469 0.883840565103612 0.0917411664538101 0.0836360942197409 0.100357660523246 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.350881893291313 0.316199225268238 0.3886249681967 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 310 3624 6250 22881 0.0472560975609756 0.0422474799511626 0.0526719349177676 0.863271080928126 0.859076317359608 0.867386032450208 0.0788002033553635 0.0705691072828231 0.0876631440170702 NA NA NA NA NA NA NA NA NA NA NA NA False True 1 1 1 0 0 0 0 0.313161589403973 0.277045984240682 0.353009682500133 NA NA NA NA NA NA 1107 5) Not assoc w R Now listed Silent mutation no 0 +Ethambutol glpK c.1137C>T glpK_c.1137C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.76624472573839 0.0479745002090283 294.932792118969 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1161C>T glpK_c.1161C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1164C>T glpK_c.1164C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1177C>T glpK_c.1177C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1179G>A glpK_c.1179G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.117G>C glpK_c.117G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 1 9479 35704 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999971992718106 0.999843963402622 0.999999290917266 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 7.53328410169849 0.392120325718966 443.147628387906 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1200G>C glpK_c.1200G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1209C>T glpK_c.1209C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.120C>T glpK_c.120C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1215C>T glpK_c.1215C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1233C>T glpK_c.1233C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.123C>A glpK_c.123C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 7 25 9474 35680 0.000738318742748655 0.00029689231210758 0.00152062336565454 0.999299817952667 0.998966565499085 0.999546829455204 0.21875 0.0927715322847193 0.399728263712107 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.05450707198648 0.384991680684972 2.5087281134014 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 5 15 6555 26490 0.000762195121951219 0.000247527523788107 0.00177780526826415 0.999434069043576 0.999066754461952 0.999683219243554 0.25 0.0865714691014345 0.491045871707957 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.34706331045003 0.382845937091423 3.90108513343283 NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1245C>T glpK_c.1245C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1257C>G glpK_c.1257C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 7 9481 35698 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.61285174975179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.40943166615857 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1257C>T glpK_c.1257C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1260G>A glpK_c.1260G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.88306962025316 0.0319145727646777 36.1783621216076 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1267T>C glpK_c.1267T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1269G>A glpK_c.1269G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 25 9481 35680 0 0 0.00038900558066021 0.999299817952667 0.998966565499085 0.999546829455204 0 0 0.137185171530712 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.598505838978095 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 22 6560 26483 0 0 0.000562171107654053 0.999169967930579 0.998743589564863 0.99947975252246 0 0 0.154372512815574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.737212705059962 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1278T>C glpK_c.1278T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1281C>T glpK_c.1281C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1293C>T glpK_c.1293C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1299C>T glpK_c.1299C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.129G>A glpK_c.129G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.-12C>G glpK_c.-12C>G 2 upstream_gene_variant 4139767 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK c.1302G>A glpK_c.1302G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1305T>C glpK_c.1305T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1317G>A glpK_c.1317G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 9478 35705 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 1 0.999896689850119 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.55639137151076 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1329G>A glpK_c.1329G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1341G>T glpK_c.1341G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 23 9481 35682 0 0 0.00038900558066021 0.999355832516454 0.999033588308985 0.99959161063274 0 0 0.148185128915224 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.654879044307434 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 21 6560 26484 0 0 0.000562171107654053 0.999207696661007 0.998789133813842 0.999509486956307 0 0 0.161097615219079 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.775545077245766 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1356C>A glpK_c.1356C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1372C>T glpK_c.1372C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1383C>T glpK_c.1383C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1395C>T glpK_c.1395C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.-13A>G glpK_c.-13A>G 2 upstream_gene_variant 4139768 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK c.1401G>A glpK_c.1401G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1422G>A glpK_c.1422G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1428T>C glpK_c.1428T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1437C>G glpK_c.1437C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1446A>C glpK_c.1446A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 12 1 9469 35704 0.0012656892732834 0.000654165731961641 0.0022098595784263 0.999971992718106 0.999843963402622 0.999999290917266 0.923076923076923 0.639702564732122 0.998054371502653 NA NA NA NA NA NA NA NA NA NA NA NA False False 45.2474390115112 6.69239695735405 1914.67957719596 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 12 1 6548 26504 0.00182926829268292 0.000945555636841848 0.00319318105848117 0.999962271269571 0.999789807096406 0.999999044791703 0.923076923076923 0.639702564732122 0.998054371502653 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 48.5717776420281 7.18300319901998 2053.57956659627 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1452C>T glpK_c.1452C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1464A>G glpK_c.1464A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1470G>A glpK_c.1470G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1488T>C glpK_c.1488T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 23 9481 35682 0 0 0.00038900558066021 0.999355832516454 0.999033588308985 0.99959161063274 0 0 0.148185128915224 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.654879044307434 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 23 6560 26482 0 0 0.000562171107654053 0.99913223920015 0.998698215498625 0.999449837068455 0 0 0.148185128915224 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.702513080401621 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1491C>G glpK_c.1491C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1503C>T glpK_c.1503C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1506C>A glpK_c.1506C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1527G>A glpK_c.1527G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 0 9477 35705 0.000421896424427802 0.000114964157806894 0.00107986688593449 1 0.999896689850119 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 2.4863933079676 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 6557 26505 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 1 0.999860832946126 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.66990152933523 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1530C>T glpK_c.1530C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.153C>T glpK_c.153C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1542T>A glpK_c.1542T>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1542T>C glpK_c.1542T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1545C>T glpK_c.1545C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1551C>A glpK_c.1551C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1551C>G glpK_c.1551C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.1551C>T glpK_c.1551C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 12 9478 35693 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.99966391261728 0.999412996653316 0.999826327071809 0.2 0.0433120051058366 0.480891133806853 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.941469719350073 0.170450014516211 3.48957054566882 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 11 6557 26494 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 0.999584983965289 0.999257543293353 0.999792807866341 0.214285714285714 0.0465792878898673 0.507975677048471 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.1019729088968 0.197343307895984 4.17304814086118 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.159C>T glpK_c.159C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 8 9481 35697 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.20624116275339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 8 6560 26497 0 0 0.000562171107654053 0.999698170156574 0.999405361976814 0.999869682578628 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.36695385477914 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.189C>T glpK_c.189C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.-18C>T glpK_c.-18C>T 2 upstream_gene_variant 4139773 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK c.-19T>G glpK_c.-19T>G 2 upstream_gene_variant 4139774 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK c.201C>A glpK_c.201C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.-20A>G glpK_c.-20A>G 2 upstream_gene_variant 4139775 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK c.-21_-20insC glpK_c.-21_-20insC 2 upstream_gene_variant 4139775 NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4529 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3733 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK c.219G>A glpK_c.219G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.234C>G glpK_c.234C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.234C>T glpK_c.234C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.238C>T glpK_c.238C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.246G>A glpK_c.246G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 23 9480 35682 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999355832516454 0.999033588308985 0.99959161063274 0.0416666666666666 0.00105435244546974 0.211201683456973 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.163648871766648 0.0039759958606088 1.00808511568168 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 20 6559 26485 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999245425391435 0.998834860097994 0.999539027227828 0.0476190476190476 0.00120488344836351 0.238159909936821 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.201898155206586 0.00487402352307712 1.26281197655001 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.261G>T glpK_c.261G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.264G>A glpK_c.264G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.267G>A glpK_c.267G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.267G>T glpK_c.267G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.27A>G glpK_c.27A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 10 9479 35695 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999719927181067 0.999484996631079 0.999865686288203 0.166666666666666 0.0208625254600923 0.484137748685967 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.753138516721173 0.0802222726697143 3.53509134535146 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 9 6558 26496 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999660441426146 0.999355510362951 0.999844720818052 0.181818181818181 0.0228311982999596 0.517755852360172 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.897834705702958 0.0943771648973915 4.33916127859324 NA NA NA NA NA NA 12 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.288G>A glpK_c.288G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.76624472573839 0.0479745002090283 294.932792118969 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.306G>A glpK_c.306G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.309C>T glpK_c.309C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.315A>G glpK_c.315A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.318G>A glpK_c.318G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.336T>C glpK_c.336T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.33C>T glpK_c.33C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.-34C>T glpK_c.-34C>T 2 upstream_gene_variant 4139789 NA 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4516 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3725 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK c.354C>G glpK_c.354C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.354C>T glpK_c.354C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.360C>T glpK_c.360C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.363C>G glpK_c.363C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.363C>T glpK_c.363C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.369G>T glpK_c.369G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.-37delC glpK_c.-37delC 2 upstream_gene_variant 4139791 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK c.-38C>T glpK_c.-38C>T 2 upstream_gene_variant 4139793 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK c.408C>G glpK_c.408C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.414G>A glpK_c.414G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.417G>A glpK_c.417G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 24 9479 35681 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999327825234561 0.999000021245735 0.999569278960296 0.0769230769230769 0.00945539100371274 0.251302916695373 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.313684636213384 0.0359269755006012 1.26386512998915 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.-41G>A glpK_c.-41G>A 2 upstream_gene_variant 4139796 NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4554 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3750 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK c.420C>T glpK_c.420C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.429G>A glpK_c.429G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.435T>A glpK_c.435T>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.-43C>A glpK_c.-43C>A 2 upstream_gene_variant 4139798 NA 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4632 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3807 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK c.-43C>T glpK_c.-43C>T 2 upstream_gene_variant 4139798 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK c.444T>G glpK_c.444T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.88306962025316 0.0319145727646777 36.1783621216076 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.450C>A glpK_c.450C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.-46C>T glpK_c.-46C>T 2 upstream_gene_variant 4139801 NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4511 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK c.-47_-45delGCG glpK_c.-47_-45delGCG 2 upstream_gene_variant 4139799 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK c.-47G>A glpK_c.-47G>A 2 upstream_gene_variant 4139802 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK c.492G>T glpK_c.492G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.495C>G glpK_c.495C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.88306962025316 0.0319145727646777 36.1783621216076 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.495C>T glpK_c.495C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.19822685561766 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 6 6560 26499 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.43165838346939 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.510C>T glpK_c.510C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 59 397 9422 35308 0.00622297226031009 0.00474049094155523 0.00801993297204606 0.988881109088363 0.987738770838784 0.989942847199795 0.12938596491228 0.099973043321806 0.163705247281014 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.556918343744502 0.415855844649384 0.734334792651895 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 48 351 6512 26154 0.0073170731707317 0.00539981756929644 0.00968980083769399 0.986757215619694 0.985307503923948 0.988098708140692 0.120300751879699 0.0900468290810147 0.156322098241187 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 0 0.549234549234549 0.396948899465365 0.745207821320331 NA NA NA NA NA NA 91 5) Not assoc w R Now listed Silent mutation no 0 +Ethambutol glpK c.525A>G glpK_c.525A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 6 9479 35699 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.99983195630864 0.999634275787128 0.999938328510354 0.25 0.0318540262499442 0.650855794412824 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.25537152301578 0.123863858669135 7.02323716133577 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.528G>A glpK_c.528G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.528G>T glpK_c.528G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.54C>T glpK_c.54C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.558C>G glpK_c.558C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.561G>T glpK_c.561G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.570G>A glpK_c.570G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.570G>C glpK_c.570G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.597C>T glpK_c.597C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.-5A>G glpK_c.-5A>G 2 upstream_gene_variant 4139760 1 14 2 12 8 18 9473 35687 0.000843792848855605 0.000364358012393849 0.00166192766222289 0.99949586892592 0.999203372130377 0.999701193476901 0.307692307692307 0.143259997927703 0.517896436445741 0.142857142857142 0.0177945154831915 0.428129160909698 0.1 0.0123485271702948 0.316982714019082 0.627872198177275 0.0682388114336655 2.82130011058224 0.747835356847017 535 4975 False False 1.67432586180606 0.629752562025303 4.04837435665948 0.00021108179419525 2.55640068579291e-05 0.000762289818459044 0.99949586892592 0.999203372130377 0.999701193476901 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 2 3 7 5 6553 26500 0.0010670731707317 0.000429122972600259 0.00219733487653492 0.999811356347858 0.999559824020536 0.9999387451734 0.583333333333333 0.276669685682105 0.848347770191569 0.4 0.0527449505263169 0.853367200365326 0.285714285714285 0.0366925661760855 0.709579136262657 2.69596622412126 0.225120716085773 23.5387399327588 0.259210938626877 182 4087 False False 0 0 0 0 0 0 0 5.66152907065466 1.54611400354312 22.6275177022285 0.00030511060259344 3.69524455207002e-05 0.00110172524921774 0.999811356347858 0.999559824020536 0.9999387451734 4 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK c.609C>T glpK_c.609C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.60C>T glpK_c.60C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.624A>C glpK_c.624A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 8 13 9473 35692 0.000843792848855605 0.000364358012393849 0.00166192766222289 0.999635905335387 0.999377467513205 0.999806121137399 0.380952380952381 0.181071625540173 0.615645609621354 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.31862215689936 0.832806698666871 6.03697214543158 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 3 6559 26502 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999886813808715 0.999669257903365 0.999976657677988 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.34685165421558 0.025651688752077 16.7753654027497 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.63C>T glpK_c.63C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.76624472573839 0.0479745002090283 294.932792118969 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.645C>T glpK_c.645C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.649C>T glpK_c.649C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 5 9479 35700 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999859963590533 0.999673232250017 0.999954529045718 0.285714285714285 0.0366925661760855 0.709579136262657 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.50648802616309 0.143410178089837 9.20379905242336 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 5 6558 26500 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999811356347858 0.999559824020536 0.9999387451734 0.285714285714285 0.0366925661760855 0.709579136262657 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.61634644708752 0.15386320830351 9.87586276350829 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.658T>C glpK_c.658T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.6C>G glpK_c.6C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.702G>C glpK_c.702G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.708G>A glpK_c.708G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.708G>T glpK_c.708G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.717T>C glpK_c.717T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.717T>G glpK_c.717T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.726C>T glpK_c.726C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.741G>T glpK_c.741G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 5 35 9476 35670 0.000527370530534753 0.000171257241502832 0.00123027414547083 0.999019745133734 0.998636963904226 0.999317124544511 0.125 0.0418596261386167 0.26803291736172 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.537749502502562 0.164402220636894 1.37894857106233 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 5 33 6555 26472 0.000762195121951219 0.000247527523788107 0.00177780526826415 0.998754951895868 0.998251929768768 0.99914281600404 0.131578947368421 0.0441374400579144 0.280863845883753 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.611885444837389 0.186409866358631 1.57811699084171 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.747C>G glpK_c.747C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.759G>A glpK_c.759G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.759G>T glpK_c.759G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.75C>A glpK_c.75C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.75C>T glpK_c.75C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.762G>A glpK_c.762G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.765C>T glpK_c.765C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.88306962025316 0.0319145727646777 36.1783621216076 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.777C>A glpK_c.777C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.777C>T glpK_c.777C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.789T>C glpK_c.789T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 2 9479 35703 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999943985436213 0.999797670939776 0.99999321630447 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.76653655448887 0.272970929153834 51.9466713138689 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 2 6558 26503 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999924542539143 0.999727448570663 0.999990861620785 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.04132357426044 0.292866339798886 55.7129032982466 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.795C>T glpK_c.795C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.-7A>G glpK_c.-7A>G 2 upstream_gene_variant 4139762 NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4517 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3726 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK c.801C>T glpK_c.801C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.816G>A glpK_c.816G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.828G>A glpK_c.828G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.843T>C glpK_c.843T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.84C>T glpK_c.84C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.852C>T glpK_c.852C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.859C>T glpK_c.859C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.864G>A glpK_c.864G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.873C>T glpK_c.873C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.87C>T glpK_c.87C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.10982832991351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.40943166615857 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.891A>G glpK_c.891A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 5 9478 35700 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999859963590533 0.999673232250017 0.999954529045718 0.375 0.0852334141372535 0.755136783633448 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.25997045790251 0.350887762500293 11.6204549580208 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 2 6557 26503 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 0.999924542539143 0.999727448570663 0.999990861620785 0.6 0.146632799634673 0.947255049473683 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 6.06290986731737 0.694321240468692 72.4391518330217 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.900C>T glpK_c.900C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 6 9479 35699 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.99983195630864 0.999634275787128 0.999938328510354 0.25 0.0318540262499442 0.650855794412824 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.25537152301578 0.123863858669135 7.02323716133577 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 3 6558 26502 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999886813808715 0.999669257903365 0.999976657677988 0.4 0.0527449505263169 0.853367200365326 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.69411405916437 0.224966079471659 23.5225659748306 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.906G>A glpK_c.906G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.912C>T glpK_c.912C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.921C>T glpK_c.921C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.936C>T glpK_c.936C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.945C>T glpK_c.945C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.969C>T glpK_c.969C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.96C>T glpK_c.96C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.19822685561766 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.978C>T glpK_c.978C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol glpK c.-9T>G glpK_c.-9T>G 2 upstream_gene_variant 4139764 NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4635 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3810 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK deletion glpK_deletion 2 feature_ablation (see "Genomic_coordinates" sheet) 1 1 0 1 1 6 9480 35699 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99983195630864 0.999634275787128 0.999938328510354 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.975 0 0 0.4592581264399 0 0 146.533114251961 1 2818.5 4975 False False 0.627619549929676 0.0136468000350686 5.17448319653473 0 0 0.00038904660702099 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 4 6559 26501 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999849085078287 0.999613643356053 0.999958879281354 0.2 0.00505076337946806 0.716417936118089 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3808 4087 False False 0 0 0 0 0 0 0 1.01010062509528 0.0205075656450505 10.2127021503241 0 0 0.000562256793434776 0.999849085078287 0.999613643356053 0.999958879281354 1 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK LoF glpK_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 215 15 200 252 319 9229 35386 0.0265794747389515 0.0234350852120451 0.0300190549430235 0.991065677076039 0.990034632518216 0.992015608295191 0.441330998248686 0.400122661408737 0.483149316953751 0.0697674418604651 0.0395714788906768 0.112460529460646 0.0449101796407185 0.0253505210578709 0.0729915287164287 0.287566366886986 0.15790062359211 0.486149784653969 4.2174185429156e-08 14 4975 True False 3.02891220294757 2.55325117631164 3.5900126174588 0.00162267416702726 0.000908473904958954 0.00267494422152022 0.991065677076039 0.990034632518216 0.992015608295191 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 138 5 133 118 215 6442 26290 0.0179878048780487 0.0149110397268536 0.0215029933440779 0.991888322957932 0.99073390366219 0.992932856093833 0.354354354354354 0.302977518677124 0.408348055583037 0.036231884057971 0.0118672422579183 0.0825263318810427 0.0227272727272727 0.00741972133889208 0.0522380491360821 0.153422208112644 0.0489969178872398 0.367333367824222 6.39422516163724e-08 14 4087 True False 0 0 0 0 0 0 0 2.23982152011147 1.77084451619002 2.82149251298277 0.00077555452148286 0.000251866870437604 0.00180894968941511 0.991888322957932 0.99073390366219 0.992932856093833 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ala111Glu glpK_p.Ala111Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ala11Val glpK_p.Ala11Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 7 9481 35698 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 4616 4975 False False 0 0 2.61285174975179 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3798 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ala139Val glpK_p.Ala139Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ala164Thr glpK_p.Ala164Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 1 9479 35704 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999971992718106 0.999843963402622 0.999999290917266 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 4502 4975 False False 7.53328410169849 0.392120325718966 443.147628387906 0 0 0.000389087642036349 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 1 6558 26504 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999962271269571 0.999789807096406 0.999999044791703 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 3715 4087 False False 0 0 0 0 0 0 0 8.08295211954864 0.420719628662148 475.373667785977 0 0 0.00056234250533983 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ala171Val glpK_p.Ala171Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 9480 35702 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99991597815432 0.999754472342108 0.99998267234027 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11649128277037 1 2818.5 4975 False False 1.25534458509142 0.0239099774609589 15.6346568618898 0 0 0.00038904660702099 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 3 6559 26502 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999886813808715 0.999669257903365 0.999976657677988 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.78133043653875 1 2276.5 4087 False False 0 0 0 0 0 0 0 1.34685165421558 0.025651688752077 16.7753654027497 0 0 0.000562256793434776 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ala18Thr glpK_p.Ala18Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ala19Val glpK_p.Ala19Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ala200Ser glpK_p.Ala200Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ala232Thr glpK_p.Ala232Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ala235Val glpK_p.Ala235Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4503 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3716 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ala245Thr glpK_p.Ala245Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4530 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3734 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ala265fs glpK_p.Ala265fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ala277Gly glpK_p.Ala277Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ala313Thr glpK_p.Ala313Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 4624 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ala318Thr glpK_p.Ala318Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4594 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3778 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ala318Val glpK_p.Ala318Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ala324Thr glpK_p.Ala324Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4519 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3727 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ala364Val glpK_p.Ala364Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 8 9481 35697 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 0 0 0.369416647552819 0 0 0.602364635616474 0 0 0.369416647552819 0 0 5.70451412549953 0.585891013520969 362 4975 False False 0 0 2.20624116275339 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3784 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 2 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ala370fs glpK_p.Ala370fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4550 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ala370Val glpK_p.Ala370Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4585 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3771 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ala377Val glpK_p.Ala377Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ala37Val glpK_p.Ala37Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4570 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3759 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ala380Val glpK_p.Ala380Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ala391Val glpK_p.Ala391Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ala394Thr glpK_p.Ala394Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ala396fs glpK_p.Ala396fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ala396Gly glpK_p.Ala396Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4538 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3739 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ala396Ser glpK_p.Ala396Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ala396Val glpK_p.Ala396Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ala400Val glpK_p.Ala400Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4591 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ala40Ser glpK_p.Ala40Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.058895521352 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 21.5173342675905 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ala414Val glpK_p.Ala414Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ala440Gly glpK_p.Ala440Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4634 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ala453Thr glpK_p.Ala453Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.058895521352 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 21.5173342675905 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ala453Val glpK_p.Ala453Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 2 9479 35703 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999943985436213 0.999797670939776 0.99999321630447 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4640 4975 False False 3.76653655448887 0.272970929153834 51.9466713138689 0 0 0.000389087642036349 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3815 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ala457Ser glpK_p.Ala457Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4565 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3754 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ala457Val glpK_p.Ala457Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ala463Glu glpK_p.Ala463Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ala463Val glpK_p.Ala463Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ala464Gly glpK_p.Ala464Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.10982832991351 0.590980565810755 492 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.40943166615857 0.590385352956204 278 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ala467Ser glpK_p.Ala467Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ala467Val glpK_p.Ala467Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4586 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3772 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ala472Glu glpK_p.Ala472Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ala472Pro glpK_p.Ala472Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4573 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3761 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ala479Thr glpK_p.Ala479Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ala498Gly glpK_p.Ala498Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ala498Thr glpK_p.Ala498Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ala501Asp glpK_p.Ala501Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ala53Val glpK_p.Ala53Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ala77Val glpK_p.Ala77Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ala86Val glpK_p.Ala86Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ala87Val glpK_p.Ala87Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4520 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3728 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 1 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Arg102Trp glpK_p.Arg102Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Arg118His glpK_p.Arg118His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Arg121Cys glpK_p.Arg121Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 9478 35705 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 1 0.999896689850119 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4512 4975 False False Inf 1.55639137151076 Inf 0 0 0.000389128685709026 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Arg131Ser glpK_p.Arg131Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 20.058335224773 1 1480 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 21.5165239024995 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Arg136Ser glpK_p.Arg136Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4551 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3747 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Arg137Cys glpK_p.Arg137Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4587 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3773 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Arg225Trp glpK_p.Arg225Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Arg297Gln glpK_p.Arg297Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Arg334Cys glpK_p.Arg334Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Arg334Gly glpK_p.Arg334Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Arg351His glpK_p.Arg351His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Arg395Ser glpK_p.Arg395Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.096562813829025 Inf 0.209821626167397 198.5 4975 False False Inf 0.096562813829025 Inf 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Arg406Cys glpK_p.Arg406Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 157.21479794295 1 1103 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Arg478Gln glpK_p.Arg478Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 146.54949493291 1 1480 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Arg509Trp glpK_p.Arg509Trp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4555 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Arg52Trp glpK_p.Arg52Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Arg66Ser glpK_p.Arg66Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4506 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3719 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Arg94Leu glpK_p.Arg94Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Asn110fs glpK_p.Asn110fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Asn183Ser glpK_p.Asn183Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4539 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Asn199fs glpK_p.Asn199fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4507 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3720 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Asn279fs glpK_p.Asn279fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 3.76624472573839 0.0479745002090283 294.932792118969 0.375621806809355 335.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 4.04085988717792 0.0514701624188962 316.380494544091 0.35743759524028 195 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Asn279Lys glpK_p.Asn279Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4597 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3780 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Asn285fs glpK_p.Asn285fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Asn299Asp glpK_p.Asn299Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 21 10 9460 35695 0.00221495622824596 0.00137159943312054 0.00338381350894567 0.999719927181067 0.999484996631079 0.999865686288203 0.677419354838709 0.48627017040725 0.83317636257704 0 0 0.409616397225003 0 0 0.30849710781876 0 0 2.61843233778661 0.35760540132106 303 4975 False False 7.92383720930232 3.56973136918683 18.8610556198679 0 0 0.000389868955347791 0.999719927181067 0.999484996631079 0.999865686288203 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 7 4 6553 26501 0.0010670731707317 0.000429122972600259 0.00219733487653492 0.999849085078287 0.999613643356053 0.999958879281354 0.636363636363636 0.307904715011677 0.890736556180901 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.78991521885363 1 2276.5 4087 False False 0 0 0 0 0 0 0 7.07717839157637 1.7983262297981 32.9530091243419 0 0 0.000562771457148547 0.999849085078287 0.999613643356053 0.999958879281354 6 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Asn312Lys glpK_p.Asn312Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4598 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3781 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Asn356Ser glpK_p.Asn356Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4641 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3816 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Asn388Lys glpK_p.Asn388Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 146.54949493291 1 1480 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 157.208880998325 1 2276.5 4087 False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 0 0 0.000562256793434776 0.999924542539143 0.999727448570663 0.999990861620785 2 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Asn390Ser glpK_p.Asn390Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4547 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3746 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Asn59Asp glpK_p.Asn59Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Asn59Lys glpK_p.Asn59Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Asn59Ser glpK_p.Asn59Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4548 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Asn76Lys glpK_p.Asn76Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Asn79fs glpK_p.Asn79fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Asn92Ser glpK_p.Asn92Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4521 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3729 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Asp120Ala glpK_p.Asp120Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4513 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3723 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 1 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Asp120Asn glpK_p.Asp120Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4583 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Asp129His glpK_p.Asp129His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Asp160Asn glpK_p.Asp160Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 6 9480 35699 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99983195630864 0.999634275787128 0.999938328510354 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.841886116991581 0 0 0.4592581264399 0 0 20.0593247276636 1 1480 4975 False False 0.627619549929676 0.0136468000350686 5.17448319653473 0 0 0.00038904660702099 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 5 6559 26500 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999811356347858 0.999559824020536 0.9999387451734 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.975 0 0 0.521823750104981 0 0 157.191130157871 1 2276.5 4087 False False 0 0 0 0 0 0 0 0.808050007623113 0.0170817619606711 7.22310074751644 0 0 0.000562256793434776 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Asp170Glu glpK_p.Asp170Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Asp170Gly glpK_p.Asp170Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Asp177Asn glpK_p.Asp177Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0615661524565 1 2818.5 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Asp177Glu glpK_p.Asp177Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Asp177Gly glpK_p.Asp177Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Asp214Gly glpK_p.Asp214Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Asp214Val glpK_p.Asp214Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4508 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Asp215Gly glpK_p.Asp215Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.096562813829025 Inf 0.209821626167397 198.5 4975 False False Inf 0.096562813829025 Inf 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.103599830448027 Inf 0.198397096627854 142 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Asp3Asn glpK_p.Asp3Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Asp407Asn glpK_p.Asp407Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.11527461591697 1 2818.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Asp407Glu glpK_p.Asp407Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Asp446Tyr glpK_p.Asp446Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Asp484Asn glpK_p.Asp484Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4577 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Asp492Gly glpK_p.Asp492Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4522 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3730 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Asp493fs glpK_p.Asp493fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4603 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3785 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Asp493Gly glpK_p.Asp493Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Asp494del glpK_p.Asp494del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Asp84Ala glpK_p.Asp84Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Asp84Glu glpK_p.Asp84Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 3 34 9478 35671 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999047752415628 0.998669581250379 0.999340453530361 0.081081081081081 0.0170435306958188 0.219096206238 NA NA NA 0 0 0.102817924259012 NA NA NA NA 4571 4975 False False 0.332078621699787 0.0652484808266002 1.05629041818086 0 0 0.000389128685709026 0.999047752415628 0.998669581250379 0.999340453530361 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 15 0 15 1 16 6559 26489 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999396340313148 0.99901987910474 0.999654918214049 0.0588235294117647 0.00148817439126663 0.28688939666722 0 0 0.218019360910534 0 0 0.205907214207822 0 0 1.1263315294944 0.0535051852437571 72 4087 False False 0 0 0 0 0 0 0 0.25241080957463 0.0060216847241531 1.62536129194261 0 0 0.000562256793434776 0.999396340313148 0.99901987910474 0.999654918214049 7 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Cys271Arg glpK_p.Cys271Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Cys271Gly glpK_p.Cys271Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Cys271Tyr glpK_p.Cys271Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4574 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3762 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Cys29Tyr glpK_p.Cys29Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 45 2 43 78 95 9403 35610 0.00822698027634215 0.00650836291861919 0.0102571535709852 0.997339308220137 0.996748405243382 0.997846824360472 0.450867052023121 0.37524874503198 0.528197897116077 0.0444444444444444 0.00542848870025094 0.151492900243339 0.0206185567010309 0.00250682976381727 0.0725021499263911 0.176143684969418 0.0206695062879508 0.676380224217715 0.00487365437973167 41 4975 False False 3.10939957572331 2.27252498153668 4.2433943108222 0.000212652844231791 2.57542835809776e-05 0.000767961850983097 0.997339308220137 0.996748405243382 0.997846824360472 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 43 1 42 62 93 6498 26412 0.00945121951219512 0.00725365586633963 0.0120998708893872 0.996491228070175 0.995703215610857 0.997167062344172 0.4 0.322245920279791 0.4816537549393 0.0232558139534883 0.000588612931593182 0.122890482701339 0.0106382978723404 0.00026930211448559 0.0578513397326704 0.0967770302950358 0.00239745117934928 0.569738491593946 0.00164434013336219 30 4087 False False 0 0 0 0 0 0 0 2.709756848261 1.93010489580124 3.78150909314745 0.000153869826127096 3.89563912444009e-06 0.000857006329161454 0.996491228070175 0.995703215610857 0.997167062344172 5 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Cys307Arg glpK_p.Cys307Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Cys307Phe glpK_p.Cys307Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Cys402Tyr glpK_p.Cys402Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Gln115Arg glpK_p.Gln115Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Gln153Pro glpK_p.Gln153Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Gln153* glpK_p.Gln153* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Gln262Arg glpK_p.Gln262Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4578 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3765 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Gln269* glpK_p.Gln269* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4532 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Gln331His glpK_p.Gln331His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Gln336His glpK_p.Gln336His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Gln345Lys glpK_p.Gln345Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Gln345Pro glpK_p.Gln345Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Gln352His glpK_p.Gln352His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Gln404Glu glpK_p.Gln404Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Gln404His glpK_p.Gln404His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4572 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3760 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Gln421His glpK_p.Gln421His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4617 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3799 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Gln439Lys glpK_p.Gln439Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Gln508* glpK_p.Gln508* 2 stop_gained (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Gln9Glu glpK_p.Gln9Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 4 9480 35701 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999887970872426 0.999713186009257 0.999969475016731 0.2 0.00505076337946806 0.716417936118089 0 0 0.841886116991581 0 0 0.602364635616474 0 0 20.0604454397456 1 2818.5 4975 False False 0.941482067510548 0.0191153149568561 9.51304376083015 0 0 0.00038904660702099 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 157.179059039538 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Glu157Gly glpK_p.Glu157Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.058895521352 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 21.5173342675905 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 1 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Glu167Gly glpK_p.Glu167Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4525 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Glu209Lys glpK_p.Glu209Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 36 0 36 16 58 9465 35647 0.00168758569771121 0.00096489905765009 0.00273909056442828 0.998375577650189 0.997900556820432 0.998766284052575 0.216216216216216 0.128932972309865 0.32723696966393 0 0 0.0973937559144919 0 0 0.0616210089039198 0 0 0.406470089663104 0.000314497849148829 25 4975 False False 1.0389493050622 0.55720506386012 1.83284189049688 0 0 0.000389663042518041 0.998375577650189 0.997900556820432 0.998766284052575 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 36 0 36 16 57 6544 26448 0.0024390243902439 0.00139473586445882 0.00395780883041526 0.997849462365591 0.997214614987384 0.99837080933495 0.21917808219178 0.130780746969945 0.331384004620654 0 0 0.0973937559144919 0 0 0.0626674809144849 0 0 0.436275247114132 0.000543159002722202 25 4087 False False 0 0 0 0 0 0 0 1.13447432762836 0.607641758467291 2.00468938783429 0 0 0.000563545221770202 0.997849462365591 0.997214614987384 0.99837080933495 4 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Glu216Gln glpK_p.Glu216Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4556 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Glu216Gly glpK_p.Glu216Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4540 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3740 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Glu230Ala glpK_p.Glu230Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 14 9481 35691 0 0 0.00038900558066021 0.999607898053494 0.999342206985133 0.999785618166341 0 0 0.231635761650116 0 0 0.4592581264399 0 0 0.231635761650116 0 0 3.19750951807891 0.354677613765111 268 4975 False False 0 0 1.13511057396106 0 0 0.00038900558066021 0.999607898053494 0.999342206985133 0.999785618166341 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 11 6560 26494 0 0 0.000562171107654053 0.999584983965289 0.999257543293353 0.999792807866341 0 0 0.284914152918154 0 0 0.4592581264399 0 0 0.284914152918154 0 0 3.43101092118934 0.605996092174049 328 4087 False False 0 0 0 0 0 0 0 0 0 1.60965686204705 0 0 0.000562171107654053 0.999584983965289 0.999257543293353 0.999792807866341 1 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Glu230Lys glpK_p.Glu230Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4541 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3741 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Glu238Ala glpK_p.Glu238Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Glu238Gly glpK_p.Glu238Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Glu276Gly glpK_p.Glu276Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 4 9480 35701 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999887970872426 0.999713186009257 0.999969475016731 0.2 0.00505076337946806 0.716417936118089 0 0 0.841886116991581 0 0 0.602364635616474 0 0 20.0604454397456 1 2818.5 4975 False False 0.941482067510548 0.0191153149568561 9.51304376083015 0 0 0.00038904660702099 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 157.21479794295 1 1103 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Glu276Lys glpK_p.Glu276Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Glu320Lys glpK_p.Glu320Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Glu347Ala glpK_p.Glu347Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Glu38Gly glpK_p.Glu38Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4523 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Glu413Lys glpK_p.Glu413Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Glu495Gly glpK_p.Glu495Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Glu57Asp glpK_p.Glu57Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4636 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3811 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Glu65Gly glpK_p.Glu65Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Glu8Gly glpK_p.Glu8Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4588 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3774 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Gly105Glu glpK_p.Gly105Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Gly150Asp glpK_p.Gly150Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4514 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Gly161Arg glpK_p.Gly161Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Gly161Glu glpK_p.Gly161Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4599 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Gly187Glu glpK_p.Gly187Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.096562813829025 Inf 0.209821626167397 198.5 4975 False False Inf 0.096562813829025 Inf 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Gly191dup glpK_p.Gly191dup 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 8 1 7 4 35 9477 35670 0.000421896424427802 0.000114964157806894 0.00107986688593449 0.999019745133734 0.998636963904226 0.999317124544511 0.102564102564102 0.0286601051260963 0.242209726950617 0.125 0.0031597235312519 0.526509670875206 0.0277777777777777 0.00070302520590478 0.145289264746853 0.537692759914982 0.011932720094634 4.18616973856612 1 2818.5 4975 False False 0.430154207931985 0.111023849488689 1.20347701742635 0.000105507491031863 2.67121483114821e-06 0.000587708362116832 0.999019745133734 0.998636963904226 0.999317124544511 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 3 28 6557 26477 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 0.998943595548009 0.998473560567847 0.999297915712891 0.0967741935483871 0.0204198626877921 0.257539064627735 0 0 0.602364635616474 0 0 0.123436118500263 0 0 6.11829624181154 1 2276.5 4087 False False 0 0 0 0 0 0 0 0.432640144665461 0.0841471843702738 1.4013450488396 0 0 0.000562428243381166 0.998943595548009 0.998473560567847 0.999297915712891 9 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Gly191fs glpK_p.Gly191fs 2 frameshift (see "Genomic_coordinates" sheet) 1 24 1 23 3 28 9478 35677 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999215796106988 0.998866804929334 0.999478840936165 0.0967741935483871 0.0204198626877921 0.257539064627735 0.0416666666666666 0.00105435244546974 0.211201683456973 0.0344827586206896 0.000872646883579922 0.177644295488722 0.163660467719295 0.00397627719383516 1.00815666074662 0.0434118879566209 84 4975 False False 0.403306152593977 0.0784476729111992 1.30611918897169 0.000105496360375567 2.67093302808208e-06 0.000587646375974446 0.999215796106988 0.998866804929334 0.999478840936165 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 13 0 13 2 14 6558 26491 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999471797774004 0.999113925067086 0.999711197799087 0.125 0.0155136038154138 0.383476236849263 0 0 0.24705263800047 0 0 0.231635761650116 0 0 1.32584242015756 0.0853177346244045 86 4087 False False 0 0 0 0 0 0 0 0.57707053544199 0.0636391925711543 2.51341888079304 0 0 0.00056234250533983 0.999471797774004 0.999113925067086 0.999711197799087 4 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Gly23Asp glpK_p.Gly23Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4625 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3803 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Gly23Val glpK_p.Gly23Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Gly247Arg glpK_p.Gly247Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4600 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3782 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Gly247Trp glpK_p.Gly247Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4542 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3742 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Gly250Asp glpK_p.Gly250Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Gly260Ala glpK_p.Gly260Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 42 9481 35663 0 0 0.00038900558066021 0.998823694160481 0.99841030518573 0.999152094778215 0 0 0.0840838549403552 NA NA NA 0 0 0.0840838549403552 NA NA NA NA 4504 4975 False True 0 0 0.345406744415038 0 0 0.00038900558066021 0.998823694160481 0.99841030518573 0.999152094778215 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 42 6560 26463 0 0 0.000562171107654053 0.998415393322014 0.997858669093897 0.998857723591602 0 0 0.0840838549403552 NA NA NA 0 0 0.0840838549403552 NA NA NA NA 3717 4087 False True 1 1 1 0 0 0 0 0 0 0.370454088994544 0 0 0.000562171107654053 0.998415393322014 0.997858669093897 0.998857723591602 4 5) Not assoc w R New NotAwR yes 5 +Ethambutol glpK p.Gly292Ser glpK_p.Gly292Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4611 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3793 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Gly301Cys glpK_p.Gly301Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4526 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3731 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Gly301Val glpK_p.Gly301Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4608 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3790 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Gly311Glu glpK_p.Gly311Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Gly338Asp glpK_p.Gly338Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4626 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Gly342dup glpK_p.Gly342dup 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Gly358del glpK_p.Gly358del 2 inframe_deletion (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4543 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Gly36Ser glpK_p.Gly36Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Gly379Ser glpK_p.Gly379Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4557 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Gly417fs glpK_p.Gly417fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4566 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3755 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Gly417Ser glpK_p.Gly417Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Gly427Ser glpK_p.Gly427Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Gly465Ala glpK_p.Gly465Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Gly469Arg glpK_p.Gly469Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4533 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3736 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Gly499fs glpK_p.Gly499fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4544 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3743 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Gly54Ser glpK_p.Gly54Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4558 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3751 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Gly89Ala glpK_p.Gly89Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Gly89Glu glpK_p.Gly89Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.His103Arg glpK_p.His103Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.His103Tyr glpK_p.His103Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.His193fs glpK_p.His193fs 2 frameshift (see "Genomic_coordinates" sheet) 1 4 0 4 2 7 9479 35698 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999803949026747 0.999596102051779 0.999921173824063 0.222222222222222 0.0281449734778982 0.600093573716312 0 0 0.602364635616474 0 0 0.409616397225003 0 0 5.7058777081606 0.585906916358302 452 4975 False False 1.07600259219628 0.109030897238266 5.65147295095111 0 0 0.000389087642036349 0.999803949026747 0.999596102051779 0.999921173824063 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 9.77910191708565 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 4 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.His35Tyr glpK_p.His35Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.His392Gln glpK_p.His392Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.His42Asp glpK_p.His42Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4604 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3786 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.His42Tyr glpK_p.His42Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ile112Thr glpK_p.Ile112Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4612 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ile112Val glpK_p.Ile112Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ile122Val glpK_p.Ile122Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ile223Thr glpK_p.Ile223Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ile255Leu glpK_p.Ile255Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4559 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3752 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 1 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ile323Val glpK_p.Ile323Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4560 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ile401Met glpK_p.Ile401Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4627 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ile429Thr glpK_p.Ile429Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4595 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3779 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ile49Thr glpK_p.Ile49Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4592 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3777 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ile5Leu glpK_p.Ile5Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ile5Met glpK_p.Ile5Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ile85Thr glpK_p.Ile85Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4575 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3763 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ile90fs glpK_p.Ile90fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ile90Thr glpK_p.Ile90Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4567 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3756 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Leu126Met glpK_p.Leu126Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Leu141Met glpK_p.Leu141Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Leu152Arg glpK_p.Leu152Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Leu152Val glpK_p.Leu152Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Leu156Val glpK_p.Leu156Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Leu172Phe glpK_p.Leu172Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Leu205Val glpK_p.Leu205Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Leu228Ala glpK_p.Leu228Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4527 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3732 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Leu228Val glpK_p.Leu228Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 8 509 9473 35196 0.000843792848855605 0.000364358012393849 0.00166192766222289 0.985744293516314 0.984460403274755 0.98694825389851 0.0154738878143133 0.00670358343360459 0.0302611466845272 NA NA NA 0 0 0.00722110897087369 NA NA NA NA 4637 4975 False True 0.0583953110868092 0.0250647618046156 0.116024889224768 0 0 0.000389334034028122 0.985744293516314 0.984460403274755 0.98694825389851 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 7 349 6553 26156 0.0010670731707317 0.000429122972600259 0.00219733487653492 0.98683267308055 0.985386822129792 0.988170282709483 0.0196629213483146 0.00794117379982097 0.0400918160600001 NA NA NA 0 0 0.0105141905451955 NA NA NA NA 3812 4087 False True 1 1 1 0 0 0 0 0.0800578225507073 0.0319445348528206 0.166834603440829 0 0 0.000562771457148547 0.98683267308055 0.985386822129792 0.988170282709483 2 5) Not assoc w R New NotAwR yes 5 +Ethambutol glpK p.Leu259Phe glpK_p.Leu259Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4549 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Leu272Val glpK_p.Leu272Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Leu287Pro glpK_p.Leu287Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4584 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3770 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Leu319Arg glpK_p.Leu319Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4534 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Leu333Ile glpK_p.Leu333Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 0 9 9481 35696 0 0 0.00038900558066021 0.99974793446296 0.999521555266748 0.999884733314884 0 0 0.336267116879942 0 0 0.369416647552819 0 0 0.336267116879942 0 0 2.20617932491131 0.217678555618335 224 4975 False False 0 0 1.90786321657339 0 0 0.00038900558066021 0.99974793446296 0.999521555266748 0.999884733314884 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 0 9 6560 26496 0 0 0.000562171107654053 0.999660441426146 0.999355510362951 0.999844720818052 0 0 0.336267116879942 0 0 0.369416647552819 0 0 0.336267116879942 0 0 2.3668645343219 0.369990583605676 229.5 4087 False False 0 0 0 0 0 0 0 0 0 2.04691100627475 0 0 0.000562171107654053 0.999660441426146 0.999355510362951 0.999844720818052 2 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Leu337fs glpK_p.Leu337fs 2 frameshift (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Leu349Pro glpK_p.Leu349Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Leu393Val glpK_p.Leu393Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4579 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3766 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Leu398Met glpK_p.Leu398Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4614 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3795 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Leu398Pro glpK_p.Leu398Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4613 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3794 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Leu420Met glpK_p.Leu420Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Leu423Phe glpK_p.Leu423Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Leu44Arg glpK_p.Leu44Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Leu466Phe glpK_p.Leu466Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 9 4 9472 35701 0.000949266954962556 0.000434154257137837 0.00180123610483098 0.999887970872426 0.999713186009257 0.999969475016731 0.692307692307692 0.385738338249294 0.909079605427903 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.71057480753169 0.585961782352689 457 4975 False False 8.48049514358108 2.36594260678395 37.6895015127872 0 0 0.000389375129702287 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 6 4 6554 26501 0.000914634146341463 0.000335726224038477 0.00198970246660848 0.999849085078287 0.999613643356053 0.999958879281354 0.6 0.262378076606945 0.878447741880172 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12664538954844 1 2276.5 4087 False False 0 0 0 0 0 0 0 6.06522734208117 1.43772437640394 29.2411370605457 0 0 0.000562685614442453 0.999849085078287 0.999613643356053 0.999958879281354 2 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Lys505Asn glpK_p.Lys505Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4561 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Lys83Glu glpK_p.Lys83Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 146.529978407112 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 2 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Met1? glpK_p.Met1? 2 start_lost (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4628 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3804 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Met206Ile glpK_p.Met206Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4580 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3767 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Met227Ile glpK_p.Met227Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12104088004766 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Met266fs glpK_p.Met266fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Met30Val glpK_p.Met30Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Met412Ile glpK_p.Met412Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 7 9481 35698 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 0 0 0.409616397225003 0 0 0.975 0 0 0.409616397225003 0 0 146.513599443889 1 2818.5 4975 False False 0 0 2.61285174975179 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 157.173142990263 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Met412Thr glpK_p.Met412Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4618 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Met412Val glpK_p.Met412Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Phe147Leu glpK_p.Phe147Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Phe16Leu glpK_p.Phe16Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Phe16Ser glpK_p.Phe16Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4605 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3787 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Phe173Tyr glpK_p.Phe173Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Phe32Cys glpK_p.Phe32Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4619 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3800 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Phe365Leu glpK_p.Phe365Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Phe369Leu glpK_p.Phe369Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4606 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3788 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Phe470Leu glpK_p.Phe470Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Pro142Ser glpK_p.Pro142Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4531 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3735 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Pro143Ser glpK_p.Pro143Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Pro143Thr glpK_p.Pro143Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4505 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3718 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Pro176Ser glpK_p.Pro176Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4524 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Pro236Ala glpK_p.Pro236Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Pro239Arg glpK_p.Pro239Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Pro239Ser glpK_p.Pro239Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Pro248Ser glpK_p.Pro248Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4552 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3748 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Pro254fs glpK_p.Pro254fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4509 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3721 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Pro254Gln glpK_p.Pro254Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Pro254Leu glpK_p.Pro254Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Pro254Ser glpK_p.Pro254Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4642 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Pro274Leu glpK_p.Pro274Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 9480 35702 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99991597815432 0.999754472342108 0.99998267234027 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11649128277037 1 2818.5 4975 False False 1.25534458509142 0.0239099774609589 15.6346568618898 0 0 0.00038904660702099 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Pro315Leu glpK_p.Pro315Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 2 5 9479 35700 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999859963590533 0.999673232250017 0.999954529045718 0.285714285714285 0.0366925661760855 0.709579136262657 0 0 0.707598226178713 0 0 0.521823750104981 0 0 9.11694228265779 1 2818.5 4975 False False 1.50648802616309 0.143410178089837 9.20379905242336 0 0 0.000389087642036349 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 2 4 6558 26501 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999849085078287 0.999613643356053 0.999958879281354 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.78245264650643 1 2276.5 4087 False False 0 0 0 0 0 0 0 2.02050930161634 0.182720640564327 14.1017085588021 0 0 0.00056234250533983 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Pro354Ser glpK_p.Pro354Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Pro354Thr glpK_p.Pro354Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Pro363Arg glpK_p.Pro363Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4593 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Pro363Ser glpK_p.Pro363Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4581 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3768 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Pro371Ser glpK_p.Pro371Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4535 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Pro474Ala glpK_p.Pro474Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Pro474Leu glpK_p.Pro474Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.10982832991351 0.590980565810755 492 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.40943166615857 0.590385352956204 278 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Pro489Arg glpK_p.Pro489Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Pro51Ala glpK_p.Pro51Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4620 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Pro51Leu glpK_p.Pro51Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Pro82Leu glpK_p.Pro82Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ser124Leu glpK_p.Ser124Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ser124Pro glpK_p.Ser124Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 2 4 2 4 9479 35701 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999887970872426 0.999713186009257 0.999969475016731 0.333333333333333 0.0432718682927417 0.777221904496487 0.333333333333333 0.0432718682927417 0.777221904496487 0.333333333333333 0.0432718682927417 0.777221904496487 1.88316278088405 0.170308362439121 13.1422755166224 0.612162559837359 528 4975 False False 1.88316278088405 0.170308362439121 13.1422755166224 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ser13Pro glpK_p.Ser13Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ser237Ala glpK_p.Ser237Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4536 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3737 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ser26Arg glpK_p.Ser26Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ser2fs glpK_p.Ser2fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ser2Phe glpK_p.Ser2Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ser2Thr glpK_p.Ser2Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ser366Cys glpK_p.Ser366Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ser375Phe glpK_p.Ser375Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4568 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3757 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ser416Ala glpK_p.Ser416Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4633 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3809 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ser416Tyr glpK_p.Ser416Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 0 0 0.602364635616474 0 0 0.4592581264399 0 0 5.70483372250837 0.585894740941386 369 4975 False False 0 0 3.19822685561766 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ser517Cys glpK_p.Ser517Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4638 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3813 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Ser73Trp glpK_p.Ser73Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Thr117Ile glpK_p.Thr117Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Thr185Ile glpK_p.Thr185Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4562 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Thr195fs glpK_p.Thr195fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Thr203Ala glpK_p.Thr203Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4609 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3791 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 1 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Thr243Lys glpK_p.Thr243Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4615 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3796 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Thr24Ala glpK_p.Thr24Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4607 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3789 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Thr256Ile glpK_p.Thr256Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4545 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3744 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Thr280Ala glpK_p.Thr280Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4563 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3753 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Thr280Asn glpK_p.Thr280Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4589 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3775 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Thr291Asn glpK_p.Thr291Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4610 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3792 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Thr304Ala glpK_p.Thr304Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4639 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3814 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Thr326Ala glpK_p.Thr326Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4564 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Thr326fs glpK_p.Thr326fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4621 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Thr326Ser glpK_p.Thr326Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Thr397Ala glpK_p.Thr397Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.11527461591697 1 2818.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Thr397Met glpK_p.Thr397Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Thr430Ala glpK_p.Thr430Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 38 9479 35667 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.998935723288054 0.998539486720009 0.99924674779982 0.05 0.00611364659935083 0.169196863959417 NA NA NA 0 0 0.0925127614158782 NA NA NA NA 4582 4975 False False 0.198038878185018 0.0231591448017876 0.766559502535627 0 0 0.000389087642036349 0.998935723288054 0.998539486720009 0.99924674779982 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 29 6558 26476 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.998905866817581 0.998429017222443 0.999267123212173 0.064516129032258 0.0079109834618547 0.214216157163402 NA NA NA 0 0 0.119444869069502 NA NA NA NA 3769 4087 False False 0 0 0 0 0 0 0 0.278428032095571 0.0321820345249674 1.10110840479394 0 0 0.00056234250533983 0.998905866817581 0.998429017222443 0.999267123212173 12 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Thr430Ser glpK_p.Thr430Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 9477 35705 0.000421896424427802 0.000114964157806894 0.00107986688593449 1 0.999896689850119 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 4546 4975 False False Inf 2.4863933079676 Inf 0 0 0.000389169738041761 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 6556 26505 0.000609756097560975 0.000166162208307701 0.00156047520083291 1 0.999860832946126 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3745 4087 False False 0 0 0 0 0 0 0 Inf 2.66797681781562 Inf 0 0 0.000562514007570737 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Thr455fs glpK_p.Thr455fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.096562813829025 Inf 0.209821626167397 198.5 4975 False False Inf 0.096562813829025 Inf 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Thr488Ile glpK_p.Thr488Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4537 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3738 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Thr490Met glpK_p.Thr490Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Thr490Ser glpK_p.Thr490Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 9.1150193618684 1 2818.5 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 9.77910191708565 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Thr510Ile glpK_p.Thr510Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4553 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3749 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Thr91Ala glpK_p.Thr91Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4569 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3758 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Thr97fs glpK_p.Thr97fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4515 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3724 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Trp100fs glpK_p.Trp100fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4629 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3805 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Trp114Arg glpK_p.Trp114Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Trp114* glpK_p.Trp114* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Trp213* glpK_p.Trp213* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Trp332Arg glpK_p.Trp332Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Trp471Cys glpK_p.Trp471Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4622 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3801 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Trp487fs glpK_p.Trp487fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Trp513Arg glpK_p.Trp513Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 9480 35702 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99991597815432 0.999754472342108 0.99998267234027 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11649128277037 1 2818.5 4975 False False 1.25534458509142 0.0239099774609589 15.6346568618898 0 0 0.00038904660702099 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 157.21479794295 1 1103 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Trp64Leu glpK_p.Trp64Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Tyr109Cys glpK_p.Tyr109Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Tyr281* glpK_p.Tyr281* 2 stop_gained (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0615661524565 1 2818.5 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3797 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Tyr308His glpK_p.Tyr308His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3817 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Tyr372Cys glpK_p.Tyr372Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4601 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3783 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Tyr372fs glpK_p.Tyr372fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Tyr462fs glpK_p.Tyr462fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Tyr500Cys glpK_p.Tyr500Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Val113Ala glpK_p.Val113Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4596 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Val113Ile glpK_p.Val113Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Val159Ile glpK_p.Val159Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Val162Leu glpK_p.Val162Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Val192fs glpK_p.Val192fs 2 frameshift (see "Genomic_coordinates" sheet) 1 158 12 146 238 245 9243 35460 0.0251028372534542 0.0220477541370391 0.0284542050348293 0.993138215936143 0.992226592459998 0.993968174723054 0.492753623188405 0.447294713998197 0.538301750452529 0.0759493670886076 0.0398587845428505 0.128909702415951 0.046692607003891 0.0243562849472011 0.0801415446820219 0.315321924477464 0.159194444685902 0.5680768926259 1.12801024535946e-05 19 4975 True False 3.72680484072889 3.09993078444429 4.47952554158639 0.0012965964343598 0.000670144102358766 0.00226379651671444 0.993138215936143 0.992226592459998 0.993968174723054 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 105 4 101 110 170 6450 26335 0.0167682926829268 0.0138011314814279 0.0201754424594158 0.993586115827202 0.992550061431365 0.994511602836277 0.392857142857142 0.335271913823066 0.452735536114361 0.0380952380952381 0.0104755933666056 0.0946722807026019 0.0229885057471264 0.00629830378314986 0.0578111711323302 0.161700821244915 0.043210135463903 0.427223167338989 3.33046878295753e-06 17 4087 True False 0 0 0 0 0 0 0 2.64190606475148 2.05596723882506 3.3830136002522 0.000619770684846606 0.000168891647637522 0.00158609193141789 0.993586115827202 0.992550061431365 0.994511602836277 136 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Val192Met glpK_p.Val192Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4528 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Val253Leu glpK_p.Val253Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12104088004766 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 1 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Val267Ile glpK_p.Val267Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4518 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Val270Phe glpK_p.Val270Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4623 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3802 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Val296Ala glpK_p.Val296Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Val296Met glpK_p.Val296Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4630 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3806 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Val325Met glpK_p.Val325Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Val330Leu glpK_p.Val330Leu 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4576 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3764 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Val353Phe glpK_p.Val353Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Val362Ala glpK_p.Val362Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Val382Ala glpK_p.Val382Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Val39Ala glpK_p.Val39Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Val39Leu glpK_p.Val39Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Val408Leu glpK_p.Val408Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4510 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3722 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Val418Asp glpK_p.Val418Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Val422Met glpK_p.Val422Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4643 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3818 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Val425Ala glpK_p.Val425Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Val442Met glpK_p.Val442Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4602 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Val452Leu glpK_p.Val452Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4631 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Val460Ala glpK_p.Val460Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 332 4070 9149 31635 0.0350174032275076 0.0314079442461584 0.0389160388459327 0.8860103626943 0.882668550378452 0.889289244237739 0.0754202635165833 0.0677895415080987 0.0836198191299644 NA NA NA 0 0 0.000905947969354501 NA NA NA NA 4590 4975 False True 0.282057651606236 0.250863049868873 0.316322747261489 0 0 0.000403119015785475 0.8860103626943 0.882668550378452 0.889289244237739 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 248 3427 6312 23078 0.0378048780487804 0.0333198495182933 0.0427065140651126 0.870703640822486 0.866604754327246 0.874721070637189 0.0674829931972789 0.059583021991284 0.0760789829230702 NA NA NA 0 0 0.00107583740323185 NA NA NA NA 3776 4087 False True 1 1 1 0 0 0 0 0.264587154198948 0.230975451730376 0.302021180003443 0 0 0.000584252492180372 0.870703640822486 0.866604754327246 0.874721070637189 672 5) Not assoc w R New NotAwR yes 5 +Ethambutol glpK p.Val460Met glpK_p.Val460Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Val468Ile glpK_p.Val468Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol glpK p.Val99Ala glpK_p.Val99Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c c.1002C>T Rv2477c_c.1002C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1008G>A Rv2477c_c.1008G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1014G>A Rv2477c_c.1014G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1030T>C Rv2477c_c.1030T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.76624472573839 0.0479745002090283 294.932792118969 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1035C>T Rv2477c_c.1035C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1038C>T Rv2477c_c.1038C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1065C>T Rv2477c_c.1065C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1068C>T Rv2477c_c.1068C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.19822685561766 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1071G>T Rv2477c_c.1071G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1086A>G Rv2477c_c.1086A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 26 9 9455 35696 0.00274232675878071 0.00179213692288159 0.00401558030584103 0.99974793446296 0.999521555266748 0.999884733314884 0.742857142857142 0.567441150305961 0.875106028083238 NA NA NA NA NA NA NA NA NA NA NA NA False False 10.9065867559786 4.95019665067366 26.4594717801366 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 25 9 6535 26496 0.00381097560975609 0.00246773475495924 0.00562064553507198 0.999660441426146 0.999355510362951 0.999844720818052 0.735294117647058 0.556384631694893 0.871182608416491 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 11.2624330527926 5.08226783316088 27.4448633877756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1098C>G Rv2477c_c.1098C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1101C>T Rv2477c_c.1101C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.76624472573839 0.0479745002090283 294.932792118969 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1104C>T Rv2477c_c.1104C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 2 9478 35703 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999943985436213 0.999797670939776 0.99999321630447 0.6 0.146632799634673 0.947255049473683 NA NA NA NA NA NA NA NA NA NA NA NA False False 5.65040092846592 0.647137685918782 67.7491623796885 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 6557 26505 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 1 0.999860832946126 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.66990152933523 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1110C>T Rv2477c_c.1110C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1116A>G Rv2477c_c.1116A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 135 9478 35570 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.996219016944405 0.995526303540484 0.996828967172892 0.0217391304347826 0.0045057659614902 0.0622154430889073 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.0833978101334083 0.0169807225786613 0.249077505699806 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 2 127 6558 26378 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.995208451235616 0.994301560784518 0.996003982878506 0.0155038759689922 0.00188313719842844 0.0548825703695903 NA NA NA NA NA NA NA NA NA NA NA NA False True 1 1 1 0 0 0 0 0.0633427225988334 0.00757124136848888 0.233673573909395 NA NA NA NA NA NA 8 5) Not assoc w R Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1122C>T Rv2477c_c.1122C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1134C>G Rv2477c_c.1134C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.114C>T Rv2477c_c.114C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1152C>A Rv2477c_c.1152C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1152C>G Rv2477c_c.1152C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1152C>T Rv2477c_c.1152C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1155G>A Rv2477c_c.1155G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1158G>A Rv2477c_c.1158G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1164C>T Rv2477c_c.1164C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.88306962025316 0.0319145727646777 36.1783621216076 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1167G>A Rv2477c_c.1167G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1167G>T Rv2477c_c.1167G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1170C>T Rv2477c_c.1170C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1176C>T Rv2477c_c.1176C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1203C>T Rv2477c_c.1203C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.120C>T Rv2477c_c.120C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1212G>A Rv2477c_c.1212G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1215T>C Rv2477c_c.1215T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1218C>A Rv2477c_c.1218C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1221G>A Rv2477c_c.1221G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.123G>T Rv2477c_c.123G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1269G>A Rv2477c_c.1269G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.76624472573839 0.0479745002090283 294.932792118969 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.126C>T Rv2477c_c.126C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1278G>A Rv2477c_c.1278G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1323T>C Rv2477c_c.1323T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1335C>T Rv2477c_c.1335C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1344C>T Rv2477c_c.1344C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1383C>A Rv2477c_c.1383C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1387C>T Rv2477c_c.1387C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1413C>T Rv2477c_c.1413C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.141C>A Rv2477c_c.141C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1422T>C Rv2477c_c.1422T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1434G>C Rv2477c_c.1434G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1443G>C Rv2477c_c.1443G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1455G>A Rv2477c_c.1455G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1473C>T Rv2477c_c.1473C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1476C>T Rv2477c_c.1476C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1491C>T Rv2477c_c.1491C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1494T>C Rv2477c_c.1494T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1497C>T Rv2477c_c.1497C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1509C>T Rv2477c_c.1509C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.150C>T Rv2477c_c.150C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1512C>T Rv2477c_c.1512C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1515G>A Rv2477c_c.1515G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1518C>T Rv2477c_c.1518C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1521G>A Rv2477c_c.1521G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1521G>T Rv2477c_c.1521G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1533G>A Rv2477c_c.1533G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1545C>T Rv2477c_c.1545C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 439 4509 9042 31196 0.0463031325809513 0.0421604461452839 0.0507273312818463 0.873715165943145 0.870225309789711 0.877144110504924 0.0887227162489894 0.0809432859394582 0.0969912387452693 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.335906721296525 0.303021693862477 0.371657530748115 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 318 3843 6242 22662 0.0484756097560975 0.0434039464373623 0.0539533032271142 0.855008488964346 0.850711943841525 0.859227048677841 0.076423936553713 0.068530949094037 0.0849175195532389 NA NA NA NA NA NA NA NA NA NA NA NA False True 1 1 1 0 0 0 0 0.300421635712447 0.266223907631965 0.338129756791442 NA NA NA NA NA NA 1125 5) Not assoc w R Now listed Silent mutation no 0 +Ethambutol Rv2477c c.156C>G Rv2477c_c.156C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1581C>G Rv2477c_c.1581C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1581C>T Rv2477c_c.1581C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1587C>T Rv2477c_c.1587C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1596C>T Rv2477c_c.1596C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1605C>T Rv2477c_c.1605C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 8 9481 35697 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.20624116275339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1620C>A Rv2477c_c.1620C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1620C>T Rv2477c_c.1620C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1626C>T Rv2477c_c.1626C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1629C>T Rv2477c_c.1629C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1635T>A Rv2477c_c.1635T>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1638A>G Rv2477c_c.1638A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1659C>T Rv2477c_c.1659C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.165C>T Rv2477c_c.165C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 5 5 9476 35700 0.000527370530534753 0.000171257241502832 0.00123027414547083 0.999859963590533 0.999673232250017 0.999954529045718 0.5 0.187086028447398 0.812913971552601 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.7674124102997 0.866815029288652 16.380547623516 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 5 5 6555 26500 0.000762195121951219 0.000247527523788107 0.00177780526826415 0.999811356347858 0.999559824020536 0.9999387451734 0.5 0.187086028447398 0.812913971552601 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.04271548436308 0.930054868102617 17.5613448179105 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1663C>T Rv2477c_c.1663C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.1674C>T Rv2477c_c.1674C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.-17_-16insT Rv2477c_c.-17_-16insT 2 upstream_gene_variant 2784058 1 0 0 0 0 12 9481 35693 0 0 0.00038900558066021 0.99966391261728 0.999412996653316 0.999826327071809 0 0 0.264648469397051 NA NA NA 0 0 0.264648469397051 NA NA NA NA 4855 4975 False False 0 0 1.35519147325258 0 0 0.00038900558066021 0.99966391261728 0.999412996653316 0.999826327071809 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 12 6560 26493 0 0 0.000562171107654053 0.999547255234861 0.999209279704825 0.999766038988972 0 0 0.264648469397051 NA NA NA 0 0 0.264648469397051 NA NA NA NA 3987 4087 False False 0 0 0 0 0 0 0 0 0 1.45386850159099 0 0 0.000562171107654053 0.999547255234861 0.999209279704825 0.999766038988972 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c c.189C>T Rv2477c_c.189C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.-1927_-28del Rv2477c_c.-1927_-28del 2 upstream_gene_variant 2784069 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4789 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3930 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c c.-1927_-66del Rv2477c_c.-1927_-66del 2 upstream_gene_variant 2784107 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4809 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3947 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c c.201C>A Rv2477c_c.201C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.204C>T Rv2477c_c.204C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.-20C>G Rv2477c_c.-20C>G 2 upstream_gene_variant 2784062 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c c.219G>A Rv2477c_c.219G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.-23G>A Rv2477c_c.-23G>A 2 upstream_gene_variant 2784065 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c c.252C>T Rv2477c_c.252C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.-25A>C Rv2477c_c.-25A>C 2 upstream_gene_variant 2784067 NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4772 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3918 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c c.270A>G Rv2477c_c.270A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.76624472573839 0.0479745002090283 294.932792118969 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.-28C>T Rv2477c_c.-28C>T 2 upstream_gene_variant 2784070 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c c.-29C>T Rv2477c_c.-29C>T 2 upstream_gene_variant 2784071 1 0 0 0 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4783 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3927 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c c.303C>T Rv2477c_c.303C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.309C>T Rv2477c_c.309C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 5 9480 35700 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999859963590533 0.999673232250017 0.999954529045718 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.753164556962025 0.0159260191955521 6.73154939272228 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 3 6559 26502 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999886813808715 0.999669257903365 0.999976657677988 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.34685165421558 0.025651688752077 16.7753654027497 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.312C>T Rv2477c_c.312C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 9 9481 35696 0 0 0.00038900558066021 0.99974793446296 0.999521555266748 0.999884733314884 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.90786321657339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 9 6560 26496 0 0 0.000562171107654053 0.999660441426146 0.999355510362951 0.999844720818052 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.04691100627475 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.318C>T Rv2477c_c.318C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 21 9481 35684 0 0 0.00038900558066021 0.99941184708024 0.99910108554872 0.999635888372764 0 0 0.161097615219079 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.722928583272661 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 19 6560 26486 0 0 0.000562171107654053 0.999283154121863 0.998880781714398 0.999568358524102 0 0 0.176466911806965 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.865443021143955 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.-31A>G Rv2477c_c.-31A>G 2 upstream_gene_variant 2784073 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c c.333C>T Rv2477c_c.333C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.-34G>A Rv2477c_c.-34G>A 2 upstream_gene_variant 2784076 NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4832 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3966 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c c.352C>T Rv2477c_c.352C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.-36A>C Rv2477c_c.-36A>C 2 upstream_gene_variant 2784078 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c c.387G>A Rv2477c_c.387G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.393C>T Rv2477c_c.393C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 20 9479 35685 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999439854362134 0.999135032404509 0.999657815983264 0.0909090909090909 0.0112055860241509 0.291612741553933 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.376463762000211 0.0426582813644047 1.5502302403742 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 19 6558 26486 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999283154121863 0.998880781714398 0.999568358524102 0.0952380952380952 0.0117493178844458 0.303774406913924 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.425129612686794 0.0480084870396489 1.762930067696 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.396C>T Rv2477c_c.396C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.399C>T Rv2477c_c.399C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.417G>A Rv2477c_c.417G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.429G>A Rv2477c_c.429G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.-43G>A Rv2477c_c.-43G>A 2 upstream_gene_variant 2784085 NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4760 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3908 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c c.-44G>A Rv2477c_c.-44G>A 2 upstream_gene_variant 2784086 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4820 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c c.453G>A Rv2477c_c.453G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.45C>T Rv2477c_c.45C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.468G>A Rv2477c_c.468G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.483C>T Rv2477c_c.483C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 1 9479 35704 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999971992718106 0.999843963402622 0.999999290917266 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 7.53328410169849 0.392120325718966 443.147628387906 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 1 6558 26504 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999962271269571 0.999789807096406 0.999999044791703 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 8.08295211954864 0.420719628662148 475.373667785977 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.489C>T Rv2477c_c.489C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.48C>T Rv2477c_c.48C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.492G>A Rv2477c_c.492G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.499C>A Rv2477c_c.499C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.-4C>A Rv2477c_c.-4C>A 2 upstream_gene_variant 2784046 NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4811 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3949 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c c.-4C>T Rv2477c_c.-4C>T 2 upstream_gene_variant 2784046 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c c.51T>C Rv2477c_c.51T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.523T>C Rv2477c_c.523T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.528C>T Rv2477c_c.528C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.538C>T Rv2477c_c.538C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.540G>A Rv2477c_c.540G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.541T>C Rv2477c_c.541T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 21 16 9460 35689 0.00221495622824596 0.00137159943312054 0.00338381350894567 0.999551883489707 0.999272388596077 0.99974384169233 0.567567567567567 0.39488442141776 0.729020626818707 NA NA NA NA NA NA NA NA NA NA NA NA False False 4.95156580338266 2.46071725711826 10.1557148450594 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 17 14 6543 26491 0.00259146341463414 0.0015103251531184 0.00414595205096253 0.999471797774004 0.999113925067086 0.999711197799087 0.548387096774193 0.360342327160816 0.726835013996264 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.91634462129647 2.27930939930103 10.7786595703015 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.549C>A Rv2477c_c.549C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.-54T>C Rv2477c_c.-54T>C 2 upstream_gene_variant 2784096 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4805 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3944 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c c.558G>A Rv2477c_c.558G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.-57C>T Rv2477c_c.-57C>T 2 upstream_gene_variant 2784099 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c c.585G>A Rv2477c_c.585G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.588G>A Rv2477c_c.588G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.612C>T Rv2477c_c.612C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.618C>T Rv2477c_c.618C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 8 9481 35697 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.20624116275339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 8 6560 26497 0 0 0.000562171107654053 0.999698170156574 0.999405361976814 0.999869682578628 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.36695385477914 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.627C>T Rv2477c_c.627C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.660C>T Rv2477c_c.660C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.696C>T Rv2477c_c.696C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.699C>T Rv2477c_c.699C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.69C>T Rv2477c_c.69C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.702C>A Rv2477c_c.702C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.705C>T Rv2477c_c.705C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.708C>A Rv2477c_c.708C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.76624472573839 0.0479745002090283 294.932792118969 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.708C>T Rv2477c_c.708C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.10982832991351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.40943166615857 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.-71C>T Rv2477c_c.-71C>T 2 upstream_gene_variant 2784113 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4797 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3938 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c c.723C>T Rv2477c_c.723C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.10982832991351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.40943166615857 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.729C>G Rv2477c_c.729C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.733C>T Rv2477c_c.733C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.-73C>G Rv2477c_c.-73C>G 2 upstream_gene_variant 2784115 1 1 0 1 2 1 9479 35704 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999971992718106 0.999843963402622 0.999999290917266 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 146.569015564619 1 2818.5 4975 False False 7.53328410169849 0.392120325718966 443.147628387906 0 0 0.000389087642036349 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3932 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c c.753G>A Rv2477c_c.753G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.75G>T Rv2477c_c.75G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.762G>A Rv2477c_c.762G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.76624472573839 0.0479745002090283 294.932792118969 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.-76C>G Rv2477c_c.-76C>G 2 upstream_gene_variant 2784118 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c c.-77T>C Rv2477c_c.-77T>C 2 upstream_gene_variant 2784119 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c c.-78delG Rv2477c_c.-78delG 2 upstream_gene_variant 2784119 1 2 0 2 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.058895521352 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c c.-7C>T Rv2477c_c.-7C>T 2 upstream_gene_variant 2784049 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c c.801C>T Rv2477c_c.801C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.813T>G Rv2477c_c.813T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.-81G>A Rv2477c_c.-81G>A 2 upstream_gene_variant 2784123 1 17 0 17 1 22 9480 35683 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999383839798347 0.999067273782758 0.999613816670924 0.0434782608695652 0.0011001686304415 0.21948660745348 0 0 0.195064322969093 0 0 0.154372512815574 0 0 0.912392836803349 0.032839980456347 79 4975 False False 0.171092251630226 0.0041488973537013 1.05877392186842 0 0 0.00038904660702099 0.999383839798347 0.999067273782758 0.999613816670924 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 13 0 13 0 18 6560 26487 0 0 0.000562171107654053 0.999320882852292 0.998926913664084 0.999597464048431 0 0 0.185301968137852 0 0 0.24705263800047 0 0 0.185301968137852 0 0 1.32523799677568 0.0853001764861163 79 4087 False False 0 0 0 0 0 0 0 0 0 0.918654117939294 0 0 0.000562171107654053 0.999320882852292 0.998926913664084 0.999597464048431 6 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c c.81T>C Rv2477c_c.81T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 0 9477 35705 0.000421896424427802 0.000114964157806894 0.00107986688593449 1 0.999896689850119 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 2.4863933079676 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.828G>A Rv2477c_c.828G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.-82A>G Rv2477c_c.-82A>G 2 upstream_gene_variant 2784124 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c c.831C>G Rv2477c_c.831C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.831C>T Rv2477c_c.831C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 7 9481 35698 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.61285174975179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 6 6560 26499 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.43165838346939 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.846C>G Rv2477c_c.846C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.-86G>A Rv2477c_c.-86G>A 2 upstream_gene_variant 2784128 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c c.870C>T Rv2477c_c.870C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.873C>T Rv2477c_c.873C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.879G>A Rv2477c_c.879G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.885A>C Rv2477c_c.885A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.-88C>T Rv2477c_c.-88C>T 2 upstream_gene_variant 2784130 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4745 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3898 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c c.-8A>G Rv2477c_c.-8A>G 2 upstream_gene_variant 2784050 1 25 0 25 1 32 9480 35673 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999103766979414 0.998735019826828 0.999386899029865 0.0303030303030303 0.000766912075048109 0.157593972272496 0 0 0.137185171530712 0 0 0.108881160679352 0 0 0.598451562094054 0.00513832260550723 46 4975 False False 0.117592958860759 0.00289163333140947 0.704166558527466 0 0 0.00038904660702099 0.999103766979414 0.998735019826828 0.999386899029865 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 20 0 20 1 24 6559 26481 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999094510469722 0.998653000996664 0.999419752318005 0.04 0.00101219969931084 0.203516913922414 0 0 0.168433470983085 0 0 0.142473597722525 0 0 0.818044416619378 0.0214227350409052 49 4087 False False 0 0 0 0 0 0 0 0.168223052294557 0.00409381903550352 1.03204236826681 0 0 0.000562256793434776 0.999094510469722 0.998653000996664 0.999419752318005 3 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c c.900G>A Rv2477c_c.900G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.90G>A Rv2477c_c.90G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.918C>T Rv2477c_c.918C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.933C>T Rv2477c_c.933C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.948C>G Rv2477c_c.948C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 11 86 9470 35619 0.00116021516717645 0.00057931301275248 0.00207499495108562 0.997591373757176 0.997026208348942 0.998072972206369 0.11340206185567 0.0579886966450377 0.193853859642924 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.481089609783649 0.231444050088554 0.904926042920545 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 4 48 6556 26457 0.000609756097560975 0.000166162208307701 0.00156047520083291 0.998189020939445 0.997599613132576 0.998664434411983 0.0769230769230769 0.0213565864913836 0.185396604383411 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.336294996949359 0.0880619954535106 0.918968386326713 NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.948C>T Rv2477c_c.948C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.951A>G Rv2477c_c.951A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.954C>A Rv2477c_c.954C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.960G>C Rv2477c_c.960G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.96C>A Rv2477c_c.96C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.96C>T Rv2477c_c.96C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.978C>T Rv2477c_c.978C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c c.9G>A Rv2477c_c.9G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 11 9481 35694 0 0 0.00038900558066021 0.999691919899173 0.999448826618347 0.999846197812 0 0 0.284914152918154 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.50034693324555 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 6 6560 26499 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.43165838346939 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2477c LoF Rv2477c_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4975 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4087 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ala134Val Rv2477c_p.Ala134Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ala139Thr Rv2477c_p.Ala139Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ala139Val Rv2477c_p.Ala139Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ala223Val Rv2477c_p.Ala223Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ala234Thr Rv2477c_p.Ala234Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ala260Arg Rv2477c_p.Ala260Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4812 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3950 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ala260Val Rv2477c_p.Ala260Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ala271Gly Rv2477c_p.Ala271Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ala277Thr Rv2477c_p.Ala277Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4851 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3983 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ala277Val Rv2477c_p.Ala277Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4862 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3994 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ala286Ser Rv2477c_p.Ala286Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ala295Val Rv2477c_p.Ala295Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 3 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ala2Val Rv2477c_p.Ala2Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4813 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3951 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 2 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ala335Thr Rv2477c_p.Ala335Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ala392Thr Rv2477c_p.Ala392Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4784 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ala392Val Rv2477c_p.Ala392Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ala394Val Rv2477c_p.Ala394Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4833 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3967 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ala424Val Rv2477c_p.Ala424Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 0 8 9481 35697 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 2.20624116275339 0.217681019156043 228.5 4975 False False 0 0 2.20624116275339 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ala428Thr Rv2477c_p.Ala428Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4834 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3968 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 2 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ala428Val Rv2477c_p.Ala428Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4794 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3936 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ala440Thr Rv2477c_p.Ala440Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4790 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3931 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ala454Glu Rv2477c_p.Ala454Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ala454Val Rv2477c_p.Ala454Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4746 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3899 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ala492Asp Rv2477c_p.Ala492Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4804 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ala520Val Rv2477c_p.Ala520Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.096562813829025 Inf 0.209821626167397 198.5 4975 False False Inf 0.096562813829025 Inf 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.103599830448027 Inf 0.198397096627854 142 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ala52Thr Rv2477c_p.Ala52Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4773 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ala531Pro Rv2477c_p.Ala531Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ala531Thr Rv2477c_p.Ala531Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4835 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3969 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ala545Val Rv2477c_p.Ala545Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ala62Thr Rv2477c_p.Ala62Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ala65Val Rv2477c_p.Ala65Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 4 1 9477 35704 0.000421896424427802 0.000114964157806894 0.00107986688593449 0.999971992718106 0.999843963402622 0.999999290917266 0.8 0.28358206388191 0.994949236620532 NA NA NA 0 0 0.975 NA NA NA NA 4785 4975 False False 15.0697478104885 1.49093500364622 739.038051857485 0 0 0.000389169738041761 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 4 1 6556 26504 0.000609756097560975 0.000166162208307701 0.00156047520083291 0.999962271269571 0.999789807096406 0.999999044791703 0.8 0.28358206388191 0.994949236620532 0 0 0.975 0 0 0.975 0 0 157.28656201851 1 2276.5 4087 False False 0 0 0 0 0 0 0 16.1708358755338 1.59970034177407 792.771744020614 0 0 0.000562514007570737 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ala68Thr Rv2477c_p.Ala68Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4826 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3963 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ala68Val Rv2477c_p.Ala68Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 1 4 9480 35701 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999887970872426 0.999713186009257 0.999969475016731 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.705755198674 0.585905489084247 449.5 4975 False False 0.941482067510548 0.0191153149568561 9.51304376083015 0 0 0.00038904660702099 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 1 4 6559 26501 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999849085078287 0.999613643356053 0.999958879281354 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12197425277659 1 2276.5 4087 False False 0 0 0 0 0 0 0 1.01010062509528 0.0205075656450505 10.2127021503241 0 0 0.000562256793434776 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Arg231Cys Rv2477c_p.Arg231Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Arg231Leu Rv2477c_p.Arg231Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4764 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3912 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Arg233Cys Rv2477c_p.Arg233Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Arg251Pro Rv2477c_p.Arg251Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4844 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3977 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Arg257Ser Rv2477c_p.Arg257Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4836 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Arg265Gln Rv2477c_p.Arg265Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Arg274Gln Rv2477c_p.Arg274Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4856 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3988 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Arg302His Rv2477c_p.Arg302His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Arg316His Rv2477c_p.Arg316His 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Arg316Ser Rv2477c_p.Arg316Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Arg346Cys Rv2477c_p.Arg346Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 18 9480 35687 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99949586892592 0.999203372130377 0.999701193476901 0.0526315789473684 0.00133162880417942 0.260280654195214 NA NA NA 0 0 0.185301968137852 NA NA NA NA 4852 4975 False False 0.20913619315518 0.00502263873391001 1.32494056057363 0 0 0.00038904660702099 0.99949586892592 0.999203372130377 0.999701193476901 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 17 6559 26488 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.99935861158272 0.998973272974466 0.999626324627714 0.0555555555555555 0.00140555616736942 0.272943599673368 NA NA NA 0 0 0.195064322969093 NA NA NA NA 3984 4087 False False 0 0 0 0 0 0 0 0.237554146525205 0.00568691332380032 1.51658119210468 0 0 0.000562256793434776 0.99935861158272 0.998973272974466 0.999626324627714 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Arg399Leu Rv2477c_p.Arg399Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4839 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3972 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Arg448His Rv2477c_p.Arg448His 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Arg450Lys Rv2477c_p.Arg450Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4750 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3902 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Arg450Ser Rv2477c_p.Arg450Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4765 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3913 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Arg450Thr Rv2477c_p.Arg450Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 4 8 9477 35697 0.000421896424427802 0.000114964157806894 0.00107986688593449 0.999775941744853 0.999558563909973 0.999903262744512 0.333333333333333 0.0992460911495833 0.651124493581186 0 0 0.521823750104981 0 0 0.369416647552819 0 0 4.11121772134145 0.59097378854038 462.5 4975 False False 1.88334916112693 0.414922500512465 7.03130983507434 0 0 0.000389169738041761 0.999775941744853 0.999558563909973 0.999903262744512 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 4 7 6556 26498 0.000609756097560975 0.000166162208307701 0.00156047520083291 0.999735898887002 0.999455926960675 0.999893811273379 0.363636363636363 0.109263443819098 0.692095284988322 0 0 0.521823750104981 0 0 0.409616397225003 0 0 4.4117895506572 0.590387138614059 300 4087 False False 0 0 0 0 0 0 0 2.30959644382463 0.495620625689422 9.09021159787481 0 0 0.000562514007570737 0.999735898887002 0.999455926960675 0.999893811273379 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Arg499Cys Rv2477c_p.Arg499Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4863 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3995 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Arg504Cys Rv2477c_p.Arg504Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 146.529978407112 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Arg539Pro Rv2477c_p.Arg539Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4859 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3991 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Arg539Trp Rv2477c_p.Arg539Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Arg546Gly Rv2477c_p.Arg546Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Arg549Thr Rv2477c_p.Arg549Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.096562813829025 Inf 0.209821626167397 198.5 4975 False False Inf 0.096562813829025 Inf 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.103599830448027 Inf 0.198397096627854 142 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Arg553His Rv2477c_p.Arg553His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Arg557Cys Rv2477c_p.Arg557Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Arg86Cys Rv2477c_p.Arg86Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Arg86His Rv2477c_p.Arg86His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 64 9480 35641 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.998207533958829 0.997711629231467 0.998619317506776 0.0153846153846153 0.000389428891097221 0.0827630877444663 NA NA NA 0 0 0.0560090893866365 NA NA NA NA 4779 4975 False True 0.0587437368143459 0.00146862776637525 0.339338678797225 0 0 0.00038904660702099 0.998207533958829 0.997711629231467 0.998619317506776 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 1 54 6559 26451 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.997962648556876 0.997342523875559 0.998469119661386 0.0181818181818181 0.000460217848795697 0.0971910157492533 NA NA NA 0 0 0.0660315142444217 NA NA NA NA 3923 4087 False True 1 1 1 0 0 0 0 0.0746810997611424 0.00186054249499465 0.434307904924135 0 0 0.000562256793434776 0.997962648556876 0.997342523875559 0.998469119661386 28 5) Not assoc w R New NotAwR yes 5 +Ethambutol Rv2477c p.Asn240Ser Rv2477c_p.Asn240Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Asn487His Rv2477c_p.Asn487His 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Asn535Ser Rv2477c_p.Asn535Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Asn80Lys Rv2477c_p.Asn80Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4755 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Asp101Asn Rv2477c_p.Asp101Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Asp101Glu Rv2477c_p.Asp101Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4827 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3964 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Asp113Tyr Rv2477c_p.Asp113Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4761 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3909 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Asp146Tyr Rv2477c_p.Asp146Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4751 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3903 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Asp17_Lys18insAsnAsp Rv2477c_p.Asp17_Lys18insAsnAsp 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Asp179Gly Rv2477c_p.Asp179Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Asp17Asn Rv2477c_p.Asp17Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Asp220Gly Rv2477c_p.Asp220Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Asp22Asn Rv2477c_p.Asp22Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 2 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Asp230Gly Rv2477c_p.Asp230Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Asp23del Rv2477c_p.Asp23del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Asp23Glu Rv2477c_p.Asp23Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Asp259Gly Rv2477c_p.Asp259Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4776 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3921 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Asp332Glu Rv2477c_p.Asp332Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Asp339Glu Rv2477c_p.Asp339Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 20 0 20 0 28 9481 35677 0 0 0.00038900558066021 0.999215796106988 0.998866804929334 0.999478840936165 0 0 0.123436118500263 0 0 0.168433470983085 0 0 0.123436118500263 0 0 0.762402180978819 0.0127495796928277 57 4975 False False 0 0 0.530020139481571 0 0 0.00038900558066021 0.999215796106988 0.998866804929334 0.999478840936165 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 21.5173342675905 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Asp374Asn Rv2477c_p.Asp374Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 10 0 10 0 11 9481 35694 0 0 0.00038900558066021 0.999691919899173 0.999448826618347 0.999846197812 0 0 0.284914152918154 0 0 0.30849710781876 0 0 0.284914152918154 0 0 1.67991826094729 0.134580049474634 134.5 4975 False False 0 0 1.50034693324555 0 0 0.00038900558066021 0.999691919899173 0.999448826618347 0.999846197812 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 0 11 6560 26494 0 0 0.000562171107654053 0.999584983965289 0.999257543293353 0.999792807866341 0 0 0.284914152918154 0 0 0.30849710781876 0 0 0.284914152918154 0 0 1.80241285445156 0.227545641029681 178 4087 False False 0 0 0 0 0 0 0 0 0 1.60965686204705 0 0 0.000562171107654053 0.999584983965289 0.999257543293353 0.999792807866341 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Asp374Glu Rv2477c_p.Asp374Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Asp408Asn Rv2477c_p.Asp408Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4747 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3900 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Asp435Glu Rv2477c_p.Asp435Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4845 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3978 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Asp503Asn Rv2477c_p.Asp503Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Asp503Gly Rv2477c_p.Asp503Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 5.70499352101301 0.585896604883905 379.5 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3970 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Asp516His Rv2477c_p.Asp516His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Asp517_Asn518dup Rv2477c_p.Asp517_Asn518dup 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 20.058335224773 1 1480 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 21.5165239024995 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Asp517Ala Rv2477c_p.Asp517Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4752 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3904 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Asp517Asn Rv2477c_p.Asp517Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Asp517Gly Rv2477c_p.Asp517Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Asp543Ala Rv2477c_p.Asp543Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Asp543Tyr Rv2477c_p.Asp543Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0615661524565 1 2818.5 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Asp55Ala Rv2477c_p.Asp55Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.19822685561766 0.354697857676227 290 4975 False False 0 0 3.19822685561766 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Asp82Gly Rv2477c_p.Asp82Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Asp95Asn Rv2477c_p.Asp95Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Asp95Gly Rv2477c_p.Asp95Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Gln196His Rv2477c_p.Gln196His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 4 1 9477 35704 0.000421896424427802 0.000114964157806894 0.00107986688593449 0.999971992718106 0.999843963402622 0.999999290917266 0.8 0.28358206388191 0.994949236620532 0 0 0.975 0 0 0.975 0 0 146.59987623386 1 2818.5 4975 False False 15.0697478104885 1.49093500364622 739.038051857485 0 0 0.000389169738041761 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Gln196Pro Rv2477c_p.Gln196Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Gln263Glu Rv2477c_p.Gln263Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Gln281His Rv2477c_p.Gln281His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Gln289Pro Rv2477c_p.Gln289Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Gln310His Rv2477c_p.Gln310His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Gln417His Rv2477c_p.Gln417His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4774 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3919 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Gln74His Rv2477c_p.Gln74His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4815 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3953 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Glu117Ala Rv2477c_p.Glu117Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Glu120Asp Rv2477c_p.Glu120Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Glu128Asp Rv2477c_p.Glu128Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Glu128Lys Rv2477c_p.Glu128Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Glu142Lys Rv2477c_p.Glu142Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Glu224Lys Rv2477c_p.Glu224Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12104088004766 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Glu238Asp Rv2477c_p.Glu238Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4786 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3928 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Glu238Val Rv2477c_p.Glu238Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 20.058335224773 1 1480 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Glu250Ala Rv2477c_p.Glu250Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.058895521352 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 21.5173342675905 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Glu268Lys Rv2477c_p.Glu268Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Glu269Lys Rv2477c_p.Glu269Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4840 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3973 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Glu293Asp Rv2477c_p.Glu293Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Glu308Asp Rv2477c_p.Glu308Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Glu308Lys Rv2477c_p.Glu308Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4762 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3910 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Glu323Ala Rv2477c_p.Glu323Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Glu323Leu Rv2477c_p.Glu323Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Glu404Asp Rv2477c_p.Glu404Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Glu447Ala Rv2477c_p.Glu447Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Glu476Ala Rv2477c_p.Glu476Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Glu476Lys Rv2477c_p.Glu476Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4756 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3906 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Glu513Ala Rv2477c_p.Glu513Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Glu513Lys Rv2477c_p.Glu513Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4816 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3954 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Glu519Asp Rv2477c_p.Glu519Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Glu519Lys Rv2477c_p.Glu519Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.10982832991351 0.590980565810755 492 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.40943166615857 0.590385352956204 278 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Glu533Gly Rv2477c_p.Glu533Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Glu538_Leu540delinsVal Rv2477c_p.Glu538_Leu540delinsVal 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4841 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3974 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Glu81Lys Rv2477c_p.Glu81Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Glu90Asp Rv2477c_p.Glu90Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4775 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3920 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Glu91Asp Rv2477c_p.Glu91Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Glu91Gly Rv2477c_p.Glu91Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4828 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Gly123Asp Rv2477c_p.Gly123Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Gly162Ser Rv2477c_p.Gly162Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4821 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3958 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Gly207Asp Rv2477c_p.Gly207Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Gly207Cys Rv2477c_p.Gly207Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Gly207Ser Rv2477c_p.Gly207Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4769 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Gly232Asp Rv2477c_p.Gly232Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.19822685561766 0.354697857676227 290 4975 False False 0 0 3.19822685561766 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 6560 26499 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.43165838346939 0.605981932438924 311.5 4087 False False 0 0 0 0 0 0 0 0 0 3.43165838346939 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Gly256Ser Rv2477c_p.Gly256Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Gly314Arg Rv2477c_p.Gly314Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Gly31Ser Rv2477c_p.Gly31Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Gly395Asp Rv2477c_p.Gly395Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.11527461591697 1 2818.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.77947080093164 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Gly409Ser Rv2477c_p.Gly409Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 146.54949493291 1 1480 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 157.208880998325 1 2276.5 4087 False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 0 0 0.000562256793434776 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Gly416Ala Rv2477c_p.Gly416Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Gly41Glu Rv2477c_p.Gly41Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 135 13 122 190 169 9291 35536 0.0200400801603206 0.0173147314608511 0.0230656132506554 0.995266769360033 0.994499014753107 0.995952161219926 0.529247910863509 0.476163685189784 0.581845886873743 0.0962962962962963 0.0522763413895587 0.159039765635224 0.0714285714285714 0.038578697668304 0.119047833748346 0.407558169284218 0.210879384387986 0.723758175612832 0.000880612051720374 30 4975 False False 4.30004477196548 3.47183706601985 5.32877003855015 0.00139724849527085 0.000744179116202564 0.0023881522704742 0.995266769360033 0.994499014753107 0.995952161219926 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 1 7 26 22 6534 26483 0.00396341463414634 0.00259061813234806 0.00580196493988117 0.999169967930579 0.998743589564863 0.99947975252246 0.541666666666666 0.391721997598907 0.686284577927824 0.125 0.0031597235312519 0.526509670875206 0.0434782608695652 0.0011001686304415 0.21948660745348 0.579015260833442 0.0128488469255405 4.50825525415251 1 2276.5 4087 False False 0 0 0 0 0 0 0 4.79003533962211 2.60821457306653 8.87303023816374 0.000153022188217291 3.87417887397089e-06 0.000852286905005794 0.999169967930579 0.998743589564863 0.99947975252246 29 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Gly433Val Rv2477c_p.Gly433Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4753 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3905 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Gly441Ala Rv2477c_p.Gly441Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 20 0 20 0 33 9481 35672 0 0 0.00038900558066021 0.999075759697521 0.998702265560311 0.99936371276009 0 0 0.105762810074579 0 0 0.168433470983085 0 0 0.105762810074579 0 0 0.762295427956921 0.0127475040619219 56 4975 False False 0 0 0.445109547012108 0 0 0.00038900558066021 0.999075759697521 0.998702265560311 0.99936371276009 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 18 0 18 0 31 6560 26474 0 0 0.000562171107654053 0.998830409356725 0.99834026667881 0.999205185871022 0 0 0.11218874692237 0 0 0.185301968137852 0 0 0.11218874692237 0 0 0.918203192338723 0.0341547098101207 62 4087 False False 0 0 0 0 0 0 0 0 0 0.510151817626531 0 0 0.000562171107654053 0.998830409356725 0.99834026667881 0.999205185871022 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Gly445Ser Rv2477c_p.Gly445Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Gly460Ser Rv2477c_p.Gly460Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4817 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3955 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Gly527Ser Rv2477c_p.Gly527Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4748 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3901 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Gly530Asp Rv2477c_p.Gly530Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Gly53Ser Rv2477c_p.Gly53Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Gly558Asp Rv2477c_p.Gly558Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Gly67Ser Rv2477c_p.Gly67Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.19822685561766 0.354697857676227 290 4975 False False 0 0 3.19822685561766 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 6560 26499 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.43165838346939 0.605981932438924 311.5 4087 False False 0 0 0 0 0 0 0 0 0 3.43165838346939 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Gly87Arg Rv2477c_p.Gly87Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4754 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Gly87Ser Rv2477c_p.Gly87Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 1 4 9480 35701 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999887970872426 0.999713186009257 0.999969475016731 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.705755198674 0.585905489084247 449.5 4975 False False 0.941482067510548 0.0191153149568561 9.51304376083015 0 0 0.00038904660702099 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 1 4 6559 26501 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999849085078287 0.999613643356053 0.999958879281354 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12197425277659 1 2276.5 4087 False False 0 0 0 0 0 0 0 1.01010062509528 0.0205075656450505 10.2127021503241 0 0 0.000562256793434776 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Gly92_Met93insIle Rv2477c_p.Gly92_Met93insIle 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4771 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3917 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Gly92Arg Rv2477c_p.Gly92Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.His189Tyr Rv2477c_p.His189Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 7 17 9474 35688 0.000738318742748655 0.00029689231210758 0.00152062336565454 0.999523876207814 0.999237788774316 0.999722616660517 0.291666666666666 0.126152088523691 0.510947813857832 NA NA NA 0 0 0.195064322969093 NA NA NA NA 4787 4975 False False 1.55109339492605 0.543612375930276 3.93655748188875 0 0 0.000389292947027732 0.999523876207814 0.999237788774316 0.999722616660517 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 7 13 6553 26492 0.0010670731707317 0.000429122972600259 0.00219733487653492 0.999509526504433 0.999161421428146 0.999738818498366 0.35 0.153909204784541 0.592188534532828 NA NA NA 0 0 0.24705263800047 NA NA NA NA 3929 4087 False False 0 0 0 0 0 0 0 2.17685381915505 0.735050702792078 5.87205160587441 0 0 0.000562771457148547 0.999509526504433 0.999161421428146 0.999738818498366 3 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.His326Arg Rv2477c_p.His326Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.His548Arg Rv2477c_p.His548Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4829 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ile20Val Rv2477c_p.Ile20Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0965601093619598 Inf 0.209826269779794 219 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.103595921751575 Inf 0.198403097023953 155.5 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ile309Met Rv2477c_p.Ile309Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ile309Ser Rv2477c_p.Ile309Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ile311Met Rv2477c_p.Ile311Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4798 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3939 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ile311Thr Rv2477c_p.Ile311Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4791 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3933 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ile337Thr Rv2477c_p.Ile337Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4792 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3934 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ile34Thr Rv2477c_p.Ile34Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.058895521352 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 21.5173342675905 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ile396Val Rv2477c_p.Ile396Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4860 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3992 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ile413Val Rv2477c_p.Ile413Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ile464Val Rv2477c_p.Ile464Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4749 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ile96Val Rv2477c_p.Ile96Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Leu109Phe Rv2477c_p.Leu109Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.11527461591697 1 2818.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.77947080093164 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 2 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Leu137Arg Rv2477c_p.Leu137Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4846 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3979 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Leu137Val Rv2477c_p.Leu137Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4777 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3922 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Leu148Pro Rv2477c_p.Leu148Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Leu160Arg Rv2477c_p.Leu160Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Leu198Phe Rv2477c_p.Leu198Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4822 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3959 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Leu198Val Rv2477c_p.Leu198Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 2 2 9479 35703 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999943985436213 0.999797670939776 0.99999321630447 0.5 0.067585986488543 0.932414013511457 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0636769343408 1 2818.5 4975 False False 3.76653655448887 0.272970929153834 51.9466713138689 0 0 0.000389087642036349 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 6558 26504 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999962271269571 0.999789807096406 0.999999044791703 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 157.238712024072 1 1103 4087 False False 0 0 0 0 0 0 0 8.08295211954864 0.420719628662148 475.373667785977 0 0 0.00056234250533983 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Leu21Phe Rv2477c_p.Leu21Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Leu227Gln Rv2477c_p.Leu227Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 4 1 9477 35704 0.000421896424427802 0.000114964157806894 0.00107986688593449 0.999971992718106 0.999843963402622 0.999999290917266 0.8 0.28358206388191 0.994949236620532 NA NA NA 0 0 0.975 NA NA NA NA 4766 4975 False False 15.0697478104885 1.49093500364622 739.038051857485 0 0 0.000389169738041761 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 4 1 6556 26504 0.000609756097560975 0.000166162208307701 0.00156047520083291 0.999962271269571 0.999789807096406 0.999999044791703 0.8 0.28358206388191 0.994949236620532 NA NA NA 0 0 0.975 NA NA NA NA 3914 4087 False False 0 0 0 0 0 0 0 16.1708358755338 1.59970034177407 792.771744020614 0 0 0.000562514007570737 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Leu245Met Rv2477c_p.Leu245Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4799 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3940 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Leu288Val Rv2477c_p.Leu288Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 12 0 12 9 21 9472 35684 0.000949266954962556 0.000434154257137837 0.00180123610483098 0.99941184708024 0.99910108554872 0.999635888372764 0.3 0.147345184754701 0.493959041462553 0 0 0.264648469397051 0 0 0.161097615219079 0 0 1.35613730136194 0.0836312435327726 118 4975 False False 1.61456322393822 0.650776087281939 3.67870353190322 0 0 0.000389375129702287 0.99941184708024 0.99910108554872 0.999635888372764 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 7 19 6553 26486 0.0010670731707317 0.000429122972600259 0.00219733487653492 0.999283154121863 0.998880781714398 0.999568358524102 0.269230769230769 0.115732213291504 0.477874789693831 0 0 0.30849710781876 0 0 0.176466911806965 0 0 1.80379186994223 0.227500262360265 173 4087 False False 0 0 0 0 0 0 0 1.48908896688539 0.528752169797196 3.70096203641153 0 0 0.000562771457148547 0.999283154121863 0.998880781714398 0.999568358524102 12 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Leu304Phe Rv2477c_p.Leu304Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Leu327His Rv2477c_p.Leu327His 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 8 9481 35697 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 0 0 0.369416647552819 0 0 0.841886116991581 0 0 0.369416647552819 0 0 20.0560940400292 1 2818.5 4975 False False 0 0 2.20624116275339 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 7 6560 26498 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 0 0 0.409616397225003 0 0 0.975 0 0 0.409616397225003 0 0 157.15539483586 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 2.80327602229365 0 0 0.000562171107654053 0.999735898887002 0.999455926960675 0.999893811273379 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Leu327Phe Rv2477c_p.Leu327Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 3 8 9478 35697 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999775941744853 0.999558563909973 0.999903262744512 0.272727272727272 0.0602177341729066 0.609742559572421 0 0 0.4592581264399 0 0 0.369416647552819 0 0 3.19906084784678 0.354721406363229 302 4975 False False 1.41236284026165 0.241278697490708 5.88592307150449 0 0 0.000389128685709026 0.999775941744853 0.999558563909973 0.999903262744512 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 6.12080991862283 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Leu370Arg Rv2477c_p.Leu370Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.19822685561766 0.354697857676227 290 4975 False False 0 0 3.19822685561766 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12104088004766 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Leu453Phe Rv2477c_p.Leu453Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Leu455Ser Rv2477c_p.Leu455Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4847 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3980 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Leu473Arg Rv2477c_p.Leu473Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Leu481Val Rv2477c_p.Leu481Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4848 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3981 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Leu486Arg Rv2477c_p.Leu486Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Leu486Pro Rv2477c_p.Leu486Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4849 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Leu502Phe Rv2477c_p.Leu502Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Leu540Phe Rv2477c_p.Leu540Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 1 9 9480 35696 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99974793446296 0.999521555266748 0.999884733314884 0.1 0.00252857854446178 0.445016117028195 0 0 0.521823750104981 0 0 0.336267116879942 0 0 4.10980139594783 0.590980695181114 512 4975 False False 0.418377871542428 0.00954775074807024 3.01988679231401 0 0 0.00038904660702099 0.99974793446296 0.999521555266748 0.999884733314884 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 6 6560 26499 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 0 0 0.4592581264399 0 0 0.707598226178713 0 0 0.4592581264399 0 0 9.77873303322018 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 3.43165838346939 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Leu54Met Rv2477c_p.Leu54Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Leu54Ser Rv2477c_p.Leu54Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4857 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3989 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Leu64Gln Rv2477c_p.Leu64Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Leu73Pro Rv2477c_p.Leu73Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4778 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Lys10Glu Rv2477c_p.Lys10Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Lys13Glu Rv2477c_p.Lys13Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Lys278Asn Rv2477c_p.Lys278Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Lys303Glu Rv2477c_p.Lys303Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 3 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Lys329Arg Rv2477c_p.Lys329Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Lys338Glu Rv2477c_p.Lys338Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Lys33Arg Rv2477c_p.Lys33Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Lys33Asn Rv2477c_p.Lys33Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 9 0 9 0 9 9481 35696 0 0 0.00038900558066021 0.99974793446296 0.999521555266748 0.999884733314884 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.336267116879942 0 0 1.90786321657339 0.219222996504786 244.5 4975 False False 0 0 1.90786321657339 0 0 0.00038900558066021 0.99974793446296 0.999521555266748 0.999884733314884 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 0 8 6560 26497 0 0 0.000562171107654053 0.999698170156574 0.999405361976814 0.999869682578628 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 2.36695385477914 0.369987659436533 226 4087 False False 0 0 0 0 0 0 0 0 0 2.36695385477914 0 0 0.000562171107654053 0.999698170156574 0.999405361976814 0.999869682578628 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Lys379Asn Rv2477c_p.Lys379Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Lys385Thr Rv2477c_p.Lys385Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Lys400Gln Rv2477c_p.Lys400Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Lys458Glu Rv2477c_p.Lys458Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4864 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3996 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Lys99Thr Rv2477c_p.Lys99Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4823 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3960 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Met1? Rv2477c_p.Met1? 2 start_lost (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4800 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3941 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Met122Val Rv2477c_p.Met122Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 33 0 33 0 34 9481 35671 0 0 0.00038900558066021 0.999047752415628 0.998669581250379 0.999340453530361 0 0 0.102817924259012 0 0 0.105762810074579 0 0 0.102817924259012 0 0 0.445097079654441 0.000822276966328855 29 4975 False False 0 0 0.431305702758142 0 0 0.00038900558066021 0.999047752415628 0.998669581250379 0.999340453530361 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 33 0 33 0 34 6560 26471 0 0 0.000562171107654053 0.99871722316544 0.998207904910638 0.999111481246239 0 0 0.102817924259012 0 0 0.105762810074579 0 0 0.102817924259012 0 0 0.477416733182107 0.00143806195364937 29 4087 False False 0 0 0 0 0 0 0 0 0 0.462612846156832 0 0 0.000562171107654053 0.99871722316544 0.998207904910638 0.999111481246239 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Met51Val Rv2477c_p.Met51Val 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4853 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3985 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Met93Ile Rv2477c_p.Met93Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Phe28Val Rv2477c_p.Phe28Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Phe306Ser Rv2477c_p.Phe306Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Phe429Leu Rv2477c_p.Phe429Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4780 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3924 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Phe488Cys Rv2477c_p.Phe488Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Phe488Leu Rv2477c_p.Phe488Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4806 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3945 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Phe488Val Rv2477c_p.Phe488Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Phe4Ser Rv2477c_p.Phe4Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 146.525883667094 1 2818.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Pro186Leu Rv2477c_p.Pro186Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Pro206Ala Rv2477c_p.Pro206Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4767 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3915 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Pro206Ser Rv2477c_p.Pro206Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Pro236His Rv2477c_p.Pro236His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Pro30Leu Rv2477c_p.Pro30Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4793 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3935 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Pro312Gln Rv2477c_p.Pro312Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Pro355Leu Rv2477c_p.Pro355Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Pro355Ser Rv2477c_p.Pro355Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4781 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3925 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Pro39Ser Rv2477c_p.Pro39Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 14 6 9467 35699 0.00147663748549731 0.000807519189222099 0.00247630687876465 0.99983195630864 0.999634275787128 0.999938328510354 0.7 0.45721081772371 0.881068409594272 0 0 0.841886116991581 0 0 0.4592581264399 0 0 20.0867967413147 1 2818.5 4975 False False 8.79873948100419 3.1751071264371 27.9639124080135 0 0 0.000389580738275926 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 14 5 6546 26500 0.00213414634146341 0.0011672334829473 0.00357814496544914 0.999811356347858 0.999559824020536 0.9999387451734 0.736842105263157 0.487970654654127 0.908534215092333 0 0 0.841886116991581 0 0 0.521823750104981 0 0 21.5616475178662 1 2276.5 4087 False False 0 0 0 0 0 0 0 11.3351665139016 3.85625355397476 40.2256392721371 0 0 0.000563373090255127 0.999811356347858 0.999559824020536 0.9999387451734 3 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Pro421Leu Rv2477c_p.Pro421Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.096562813829025 Inf 0.209821626167397 198.5 4975 False False Inf 0.096562813829025 Inf 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.103599830448027 Inf 0.198397096627854 142 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Pro434Gln Rv2477c_p.Pro434Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 8 0 9473 35705 0.000843792848855605 0.000364358012393849 0.00166192766222289 1 0.999896689850119 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 4842 4975 False False Inf 6.43199985370502 Inf 0 0 0.000389334034028122 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 7 0 6553 26505 0.0010670731707317 0.000429122972600259 0.00219733487653492 1 0.999860832946126 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 3975 4087 False False 0 0 0 0 0 0 0 Inf 5.82744514485438 Inf 0 0 0.000562771457148547 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Pro489Leu Rv2477c_p.Pro489Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Pro489Ser Rv2477c_p.Pro489Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4824 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3961 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Pro547Leu Rv2477c_p.Pro547Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Pro57Leu Rv2477c_p.Pro57Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Pro77Leu Rv2477c_p.Pro77Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Pro77Ser Rv2477c_p.Pro77Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Pro77Thr Rv2477c_p.Pro77Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4818 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3956 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Pro78Ala Rv2477c_p.Pro78Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Pro78Gln Rv2477c_p.Pro78Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Pro78Ser Rv2477c_p.Pro78Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ser176Ala Rv2477c_p.Ser176Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4788 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ser176Pro Rv2477c_p.Ser176Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4830 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ser242Pro Rv2477c_p.Ser242Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4795 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ser27Gly Rv2477c_p.Ser27Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 9 9481 35696 0 0 0.00038900558066021 0.99974793446296 0.999521555266748 0.999884733314884 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 4819 4975 False False 0 0 1.90786321657339 0 0 0.00038900558066021 0.99974793446296 0.999521555266748 0.999884733314884 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3957 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ser27Ile Rv2477c_p.Ser27Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4838 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3971 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ser341Ala Rv2477c_p.Ser341Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ser341Trp Rv2477c_p.Ser341Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ser375Gly Rv2477c_p.Ser375Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ser377Cys Rv2477c_p.Ser377Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4831 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3965 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ser407Ala Rv2477c_p.Ser407Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ser407Leu Rv2477c_p.Ser407Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4854 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3986 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ser427Leu Rv2477c_p.Ser427Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ser46Asn Rv2477c_p.Ser46Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ser480Leu Rv2477c_p.Ser480Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4768 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3916 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ser480Trp Rv2477c_p.Ser480Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Ter559Glnext*? Rv2477c_p.Ter559Glnext*? 2 stop_lost (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Thr112Asn Rv2477c_p.Thr112Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4757 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3907 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Thr112Ile Rv2477c_p.Thr112Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Thr187Ala Rv2477c_p.Thr187Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4837 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Thr267Ile Rv2477c_p.Thr267Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.096562813829025 Inf 0.209821626167397 198.5 4975 False False Inf 0.096562813829025 Inf 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.103599830448027 Inf 0.198397096627854 142 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Thr362Ala Rv2477c_p.Thr362Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4861 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3993 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Thr366Ala Rv2477c_p.Thr366Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Thr372Lys Rv2477c_p.Thr372Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 27 1 26 4 72 9477 35633 0.000421896424427802 0.000114964157806894 0.00107986688593449 0.997983475703683 0.997461185605247 0.99842186970701 0.0526315789473684 0.0145245583391564 0.129309158452984 0.037037037037037 0.000937257091944708 0.189705617413044 0.0136986301369863 0.000346759152599127 0.0739763231783441 0.144613274242903 0.00353074145070484 0.880542059380434 0.0297975288000444 73 4975 False False 0.208885840573083 0.0553813602930605 0.558615768451253 0.000105507491031863 2.67121483114821e-06 0.000587708362116832 0.997983475703683 0.997461185605247 0.99842186970701 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 24 1 23 4 67 6556 26438 0.000609756097560975 0.000166162208307701 0.00156047520083291 0.997472175061309 0.996790847475922 0.998040449773907 0.056338028169014 0.0155616350412414 0.138011443220829 0.0416666666666666 0.00105435244546974 0.211201683456973 0.0147058823529411 0.00037225140289861 0.079233989912788 0.175332254556065 0.00425934221787191 1.0801723037325 0.0688271926078697 77 4087 False False 0 0 0 0 0 0 0 0.240754737599373 0.0637011968015265 0.646034052559741 0.000152508769254232 3.86118028152325e-06 0.000849428314837321 0.997472175061309 0.996790847475922 0.998040449773907 5 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Thr418Ala Rv2477c_p.Thr418Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Thr505Arg Rv2477c_p.Thr505Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4810 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3948 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Thr505Met Rv2477c_p.Thr505Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Thr551Ile Rv2477c_p.Thr551Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Thr7Met Rv2477c_p.Thr7Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.058895521352 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Trp512Arg Rv2477c_p.Trp512Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Trp512Ser Rv2477c_p.Trp512Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Trp522Leu Rv2477c_p.Trp522Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4807 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3946 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Trp524Arg Rv2477c_p.Trp524Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4808 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Tyr114Asp Rv2477c_p.Tyr114Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Tyr114Cys Rv2477c_p.Tyr114Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4843 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3976 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Tyr114Ser Rv2477c_p.Tyr114Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Tyr237Cys Rv2477c_p.Tyr237Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4814 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3952 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Val106Ile Rv2477c_p.Val106Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4796 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3937 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Val157Ala Rv2477c_p.Val157Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Val168Ala Rv2477c_p.Val168Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4850 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3982 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Val195Met Rv2477c_p.Val195Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Val313Leu Rv2477c_p.Val313Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Val313Phe Rv2477c_p.Val313Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 9478 35705 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 1 0.999896689850119 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4801 4975 False False Inf 1.55639137151076 Inf 0 0 0.000389128685709026 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3942 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Val320Met Rv2477c_p.Val320Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 0 9 9481 35696 0 0 0.00038900558066021 0.99974793446296 0.999521555266748 0.999884733314884 0 0 0.336267116879942 0 0 0.369416647552819 0 0 0.336267116879942 0 0 2.20617932491131 0.217678555618335 224 4975 False False 0 0 1.90786321657339 0 0 0.00038900558066021 0.99974793446296 0.999521555266748 0.999884733314884 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 0 9 6560 26496 0 0 0.000562171107654053 0.999660441426146 0.999355510362951 0.999844720818052 0 0 0.336267116879942 0 0 0.369416647552819 0 0 0.336267116879942 0 0 2.3668645343219 0.369990583605676 229.5 4087 False False 0 0 0 0 0 0 0 0 0 2.04691100627475 0 0 0.000562171107654053 0.999660441426146 0.999355510362951 0.999844720818052 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Val322Ile Rv2477c_p.Val322Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.058895521352 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Val324Ala Rv2477c_p.Val324Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4825 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3962 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Val324Ile Rv2477c_p.Val324Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Val350Phe Rv2477c_p.Val350Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Val352Ala Rv2477c_p.Val352Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4865 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3997 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Val358Ile Rv2477c_p.Val358Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Val368Phe Rv2477c_p.Val368Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 2 3 9479 35702 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.99991597815432 0.999754472342108 0.99998267234027 0.4 0.0527449505263169 0.853367200365326 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11745289828119 1 1480 4975 False False 2.51095403875232 0.209684820120099 21.9222407664312 0 0 0.000389087642036349 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 2 3 6558 26502 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999886813808715 0.999669257903365 0.999976657677988 0.4 0.0527449505263169 0.853367200365326 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.78282164268659 1 2276.5 4087 False False 0 0 0 0 0 0 0 2.69411405916437 0.224966079471659 23.5225659748306 0 0 0.00056234250533983 0.999886813808715 0.999669257903365 0.999976657677988 3 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Val389_Asp390insGly Rv2477c_p.Val389_Asp390insGly 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4858 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3990 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Val389Met Rv2477c_p.Val389Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Val405Gly Rv2477c_p.Val405Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 5 0 9476 35705 0.000527370530534753 0.000171257241502832 0.00123027414547083 1 0.999896689850119 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 4758 4975 False False Inf 3.45192218064103 Inf 0 0 0.000389210799037296 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Val406Phe Rv2477c_p.Val406Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4802 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Val420Ala Rv2477c_p.Val420Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4759 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Val426Ala Rv2477c_p.Val426Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 2 3 9479 35702 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.99991597815432 0.999754472342108 0.99998267234027 0.4 0.0527449505263169 0.853367200365326 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11745289828119 1 1480 4975 False False 2.51095403875232 0.209684820120099 21.9222407664312 0 0 0.000389087642036349 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 2 3 6558 26502 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999886813808715 0.999669257903365 0.999976657677988 0.4 0.0527449505263169 0.853367200365326 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.78282164268659 1 2276.5 4087 False False 0 0 0 0 0 0 0 2.69411405916437 0.224966079471659 23.5225659748306 0 0 0.00056234250533983 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Val426Met Rv2477c_p.Val426Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 3 6 9478 35699 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.99983195630864 0.999634275787128 0.999938328510354 0.333333333333333 0.0748546314196918 0.700704943791459 NA NA NA 0 0 0.4592581264399 NA NA NA NA 4866 4975 False False 1.88325596117324 0.304716275204421 8.82053669197219 0 0 0.000389128685709026 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 3 6 6557 26499 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 0.99977362761743 0.99950734823901 0.999916920939814 0.333333333333333 0.0748546314196918 0.700704943791459 NA NA NA 0 0 0.4592581264399 NA NA NA NA 3998 4087 False False 0 0 0 0 0 0 0 2.02066493823394 0.326902652558114 9.46561101611652 0 0 0.000562428243381166 0.99977362761743 0.99950734823901 0.999916920939814 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Val442Leu Rv2477c_p.Val442Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4803 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3943 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Val475Gly Rv2477c_p.Val475Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Val493Met Rv2477c_p.Val493Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.11527461591697 1 2818.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Val542Ala Rv2477c_p.Val542Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Val550fs Rv2477c_p.Val550fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4770 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Val550Leu Rv2477c_p.Val550Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Val70Ala Rv2477c_p.Val70Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 7 9480 35698 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999803949026747 0.999596102051779 0.999921173824063 0.125 0.0031597235312519 0.526509670875206 NA NA NA 0 0 0.409616397225003 NA NA NA NA 4763 4975 False False 0.53794454490657 0.0119383062528594 4.18812953339448 0 0 0.00038904660702099 0.999803949026747 0.999596102051779 0.999921173824063 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 4 6559 26501 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999849085078287 0.999613643356053 0.999958879281354 0.2 0.00505076337946806 0.716417936118089 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3911 4087 False False 0 0 0 0 0 0 0 1.01010062509528 0.0205075656450505 10.2127021503241 0 0 0.000562256793434776 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Val70Met Rv2477c_p.Val70Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Val85Ile Rv2477c_p.Val85Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 22 110 9459 35595 0.00232043033435291 0.00145475495743568 0.00351106397704452 0.996919198991738 0.996287976391184 0.997467296332536 0.166666666666666 0.107495783003327 0.24139091374557 NA NA NA 0 0 0.0329791940322197 NA NA NA NA 4782 4975 False True 0.752616555661274 0.452979289459239 1.19820339764105 0 0 0.000389910164031428 0.996919198991738 0.996287976391184 0.997467296332536 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 13 84 6547 26421 0.00198170731707317 0.00105558440345171 0.00338639575788259 0.996830786644029 0.996077779173073 0.997471347621001 0.134020618556701 0.0733336812183207 0.218270921125631 NA NA NA 0 0 0.042964919629565 NA NA NA NA 3926 4087 False True 0 1 1 0 0 0 0 0.624555412511728 0.319162342081229 1.12770025792799 0 0 0.000563287063923973 0.996830786644029 0.996077779173073 0.997471347621001 5 5) Not assoc w R New NotAwR yes 5 +Ethambutol Rv2477c p.Val89Ala Rv2477c_p.Val89Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2477c p.Val89Met Rv2477c_p.Val89Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 9479 35704 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999971992718106 0.999843963402622 0.999999290917266 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 146.569015564619 1 2818.5 4975 False False 7.53328410169849 0.392120325718966 443.147628387906 0 0 0.000389087642036349 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c c.1014G>T Rv2752c_c.1014G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1017G>A Rv2752c_c.1017G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1018C>T Rv2752c_c.1018C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1026C>G Rv2752c_c.1026C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1029C>G Rv2752c_c.1029C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1035G>A Rv2752c_c.1035G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1050A>C Rv2752c_c.1050A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1050A>T Rv2752c_c.1050A>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.105A>G Rv2752c_c.105A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1063C>T Rv2752c_c.1063C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 9 64 9472 35641 0.000949266954962556 0.000434154257137837 0.00180123610483098 0.998207533958829 0.997711629231467 0.998619317506776 0.123287671232876 0.0579549157073461 0.22117978269454 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.529140163112331 0.231404387416259 1.06912793133992 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 5 34 6555 26471 0.000762195121951219 0.000247527523788107 0.00177780526826415 0.99871722316544 0.998207904910638 0.999111481246239 0.128205128205128 0.0429683430017891 0.274299410444715 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.593866379503746 0.181247197980604 1.52723700532308 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1068C>T Rv2752c_c.1068C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1074C>T Rv2752c_c.1074C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 10 9479 35695 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999719927181067 0.999484996631079 0.999865686288203 0.166666666666666 0.0208625254600923 0.484137748685967 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.753138516721173 0.0802222726697143 3.53509134535146 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.-10T>C Rv2752c_c.-10T>C 2 upstream_gene_variant 3066201 1 1 0 1 2 1 9479 35704 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999971992718106 0.999843963402622 0.999999290917266 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 146.569015564619 1 2818.5 4975 False False 7.53328410169849 0.392120325718966 443.147628387906 0 0 0.000389087642036349 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 6558 26504 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999962271269571 0.999789807096406 0.999999044791703 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 157.238712024072 1 1103 4087 False False 0 0 0 0 0 0 0 8.08295211954864 0.420719628662148 475.373667785977 0 0 0.00056234250533983 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c c.1104A>G Rv2752c_c.1104A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1107G>A Rv2752c_c.1107G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1119C>G Rv2752c_c.1119C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.111G>A Rv2752c_c.111G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1122C>G Rv2752c_c.1122C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1122C>T Rv2752c_c.1122C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1128G>C Rv2752c_c.1128G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1134C>T Rv2752c_c.1134C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 17 9481 35688 0 0 0.00038900558066021 0.999523876207814 0.999237788774316 0.999722616660517 0 0 0.195064322969093 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.912424392898866 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 17 6560 26488 0 0 0.000562171107654053 0.99935861158272 0.998973272974466 0.999626324627714 0 0 0.195064322969093 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.978828254384716 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1137T>C Rv2752c_c.1137T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 7 6 9474 35699 0.000738318742748655 0.00029689231210758 0.00152062336565454 0.99983195630864 0.999634275787128 0.999938328510354 0.538461538461538 0.251345482270303 0.807767558198712 NA NA NA NA NA NA NA NA NA NA NA NA False False 4.39611920343396 1.26467210709305 15.8376646413424 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1144C>T Rv2752c_c.1144C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1152C>G Rv2752c_c.1152C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1155C>T Rv2752c_c.1155C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1158C>T Rv2752c_c.1158C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1161G>A Rv2752c_c.1161G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1167G>A Rv2752c_c.1167G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 15 9480 35690 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.9995798907716 0.999307188228015 0.999764849596654 0.0625 0.00158111172276588 0.302320738434531 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.25098452883263 0.0059648899607233 1.63179223830413 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 6 6560 26499 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.43165838346939 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1173C>T Rv2752c_c.1173C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.120G>A Rv2752c_c.120G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1212C>G Rv2752c_c.1212C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1221C>T Rv2752c_c.1221C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1225C>T Rv2752c_c.1225C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1239C>G Rv2752c_c.1239C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1239C>T Rv2752c_c.1239C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1242C>T Rv2752c_c.1242C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1248G>A Rv2752c_c.1248G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1251A>G Rv2752c_c.1251A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1269C>T Rv2752c_c.1269C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1275C>T Rv2752c_c.1275C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.10982832991351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.40943166615857 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1278T>C Rv2752c_c.1278T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1281C>T Rv2752c_c.1281C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1287C>A Rv2752c_c.1287C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1287C>T Rv2752c_c.1287C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1290C>T Rv2752c_c.1290C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1314C>T Rv2752c_c.1314C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1317C>A Rv2752c_c.1317C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1317C>G Rv2752c_c.1317C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 7 17 9474 35688 0.000738318742748655 0.00029689231210758 0.00152062336565454 0.999523876207814 0.999237788774316 0.999722616660517 0.291666666666666 0.126152088523691 0.510947813857832 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.55109339492605 0.543612375930276 3.93655748188875 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 7 16 6553 26489 0.0010670731707317 0.000429122972600259 0.00219733487653492 0.999396340313148 0.99901987910474 0.999654918214049 0.304347826086956 0.132102879698099 0.529191666008506 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.76849343811994 0.614999038922922 4.54583743397584 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1320T>C Rv2752c_c.1320T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.135C>T Rv2752c_c.135C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.10982832991351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1380C>T Rv2752c_c.1380C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1383C>A Rv2752c_c.1383C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1404G>A Rv2752c_c.1404G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1419C>A Rv2752c_c.1419C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1428C>T Rv2752c_c.1428C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1431C>T Rv2752c_c.1431C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1438A>C Rv2752c_c.1438A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1452C>T Rv2752c_c.1452C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1467G>A Rv2752c_c.1467G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1467G>T Rv2752c_c.1467G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1470A>G Rv2752c_c.1470A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1473T>C Rv2752c_c.1473T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.19822685561766 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1479C>T Rv2752c_c.1479C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1485G>A Rv2752c_c.1485G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1491C>T Rv2752c_c.1491C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1503C>T Rv2752c_c.1503C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 10 9478 35695 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999719927181067 0.999484996631079 0.999865686288203 0.23076923076923 0.0503810734911515 0.53813153923404 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.1298269677147 0.199764717731683 4.38926258928456 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 6 6557 26499 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 0.99977362761743 0.99950734823901 0.999916920939814 0.333333333333333 0.0748546314196918 0.700704943791459 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.02066493823394 0.326902652558114 9.46561101611652 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1509G>A Rv2752c_c.1509G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1509G>T Rv2752c_c.1509G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1521C>T Rv2752c_c.1521C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1527C>T Rv2752c_c.1527C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1539A>C Rv2752c_c.1539A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1560C>T Rv2752c_c.1560C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 135 2093 9346 33612 0.0142390043244383 0.011951637707196 0.0168314948294771 0.941380758997339 0.93889402138306 0.943795397318648 0.0605924596050269 0.0510446595655609 0.0713149910613299 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.231970692153611 0.193188035751023 0.276635327581517 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 112 1648 6448 24857 0.0170731707317073 0.0140782264133391 0.0205077075547879 0.937823052254291 0.934848775675911 0.940700894278792 0.0636363636363636 0.0526832788401982 0.076070163173302 NA NA NA NA NA NA NA NA NA NA NA NA False True 1 1 1 0 0 0 0 0.261989869666819 0.213982425938422 0.318064184805327 NA NA NA NA NA NA 316 5) Not assoc w R Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1566C>T Rv2752c_c.1566C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.156C>T Rv2752c_c.156C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1572C>A Rv2752c_c.1572C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1596G>A Rv2752c_c.1596G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 8 9481 35697 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.20624116275339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 8 6560 26497 0 0 0.000562171107654053 0.999698170156574 0.999405361976814 0.999869682578628 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.36695385477914 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1599G>A Rv2752c_c.1599G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1602C>T Rv2752c_c.1602C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1608G>T Rv2752c_c.1608G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1614C>T Rv2752c_c.1614C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1623G>A Rv2752c_c.1623G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.162G>A Rv2752c_c.162G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1635T>C Rv2752c_c.1635T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1638C>T Rv2752c_c.1638C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1656G>A Rv2752c_c.1656G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.88306962025316 0.0319145727646777 36.1783621216076 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1662G>T Rv2752c_c.1662G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1671G>A Rv2752c_c.1671G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.1676A>G Rv2752c_c.1676A>G 2 stop_retained_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.-17C>G Rv2752c_c.-17C>G 2 upstream_gene_variant 3066208 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4429 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3660 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c c.183G>A Rv2752c_c.183G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 14 9477 35691 0.000421896424427802 0.000114964157806894 0.00107986688593449 0.999607898053494 0.999342206985133 0.999785618166341 0.222222222222222 0.0640920477176664 0.47637276573648 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.07601863157418 0.257834466158144 3.42722990821387 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 4 12 6556 26493 0.000609756097560975 0.000166162208307701 0.00156047520083291 0.999547255234861 0.999209279704825 0.999766038988972 0.25 0.0726620382528822 0.523770819896127 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.34701037217815 0.316548965477252 4.44644173737944 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.201C>T Rv2752c_c.201C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.207C>T Rv2752c_c.207C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.210G>C Rv2752c_c.210G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.222C>T Rv2752c_c.222C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.229C>T Rv2752c_c.229C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.231G>C Rv2752c_c.231G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.234G>A Rv2752c_c.234G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 8 12 9473 35693 0.000843792848855605 0.000364358012393849 0.00166192766222289 0.99966391261728 0.999412996653316 0.999826327071809 0.4 0.191190060725307 0.63945741269251 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.51191104542735 0.890363508306432 6.68478167232564 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 8 12 6552 26493 0.00121951219512195 0.000526641184096925 0.00240150352406598 0.999547255234861 0.999209279704825 0.999766038988972 0.4 0.191190060725307 0.63945741269251 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.69566544566544 0.95536943846236 7.17471229456488 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.240C>T Rv2752c_c.240C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.243C>T Rv2752c_c.243C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.249C>T Rv2752c_c.249C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.24A>G Rv2752c_c.24A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.264G>C Rv2752c_c.264G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.-26A>G Rv2752c_c.-26A>G 2 upstream_gene_variant 3066217 NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4210 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c c.282C>G Rv2752c_c.282C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.-29C>T Rv2752c_c.-29C>T 2 upstream_gene_variant 3066220 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c c.306C>G Rv2752c_c.306C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.30C>T Rv2752c_c.30C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.-30T>C Rv2752c_c.-30T>C 2 upstream_gene_variant 3066221 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4392 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c c.312C>T Rv2752c_c.312C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.-31A>G Rv2752c_c.-31A>G 2 upstream_gene_variant 3066222 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c c.325T>C Rv2752c_c.325T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.330T>G Rv2752c_c.330T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.333G>C Rv2752c_c.333G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.339A>G Rv2752c_c.339A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.-34G>C Rv2752c_c.-34G>C 2 upstream_gene_variant 3066225 NA 0 0 0 18 1 9463 35704 0.00189853390992511 0.00112556752776016 0.00299884872837589 0.999971992718106 0.999843963402622 0.999999290917266 0.947368421052631 0.739719345804785 0.99866837119582 NA NA NA 0 0 0.975 NA NA NA NA 4382 4975 False False 67.9141921166649 10.7199694212998 2786.68623463997 0 0 0.00038974538154329 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 18 1 6542 26504 0.00274390243902439 0.00162699615274529 0.00433309514094649 0.999962271269571 0.999789807096406 0.999999044791703 0.947368421052631 0.739719345804785 0.99866837119582 NA NA NA 0 0 0.975 NA NA NA NA 3626 4087 False False 0 0 0 0 0 0 0 72.9244879241822 11.5082489523152 2988.24479946691 0 0 0.000563717458502632 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c c.360C>T Rv2752c_c.360C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 17 9481 35688 0 0 0.00038900558066021 0.999523876207814 0.999237788774316 0.999722616660517 0 0 0.195064322969093 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.912424392898866 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 15 6560 26490 0 0 0.000562171107654053 0.999434069043576 0.999066754461952 0.999683219243554 0 0 0.218019360910534 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.12620234951212 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.366A>C Rv2752c_c.366A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.-36C>T Rv2752c_c.-36C>T 2 upstream_gene_variant 3066227 1 1 0 1 0 8 9481 35697 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 0 0 0.369416647552819 0 0 0.975 0 0 0.369416647552819 0 0 146.50950470177 1 2818.5 4975 False False 0 0 2.20624116275339 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 8 6560 26497 0 0 0.000562171107654053 0.999698170156574 0.999405361976814 0.999869682578628 0 0 0.369416647552819 0 0 0.975 0 0 0.369416647552819 0 0 157.149478782199 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 2.36695385477914 0 0 0.000562171107654053 0.999698170156574 0.999405361976814 0.999869682578628 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c c.378C>A Rv2752c_c.378C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 1 9479 35704 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999971992718106 0.999843963402622 0.999999290917266 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 7.53328410169849 0.392120325718966 443.147628387906 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.387C>G Rv2752c_c.387C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.387C>T Rv2752c_c.387C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.88306962025316 0.0319145727646777 36.1783621216076 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.-38T>G Rv2752c_c.-38T>G 2 upstream_gene_variant 3066229 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c c.-39_-32delCTTCGGTG Rv2752c_c.-39_-32delCTTCGGTG 2 upstream_gene_variant 3066222 1 2 1 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 3.76624472573839 0.0479745002090283 294.932792118969 0.375621806809355 335.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c c.39C>A Rv2752c_c.39C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.-3G>T Rv2752c_c.-3G>T 2 upstream_gene_variant 3066194 1 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c c.438C>T Rv2752c_c.438C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.450T>G Rv2752c_c.450T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.45G>T Rv2752c_c.45G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.-46C>T Rv2752c_c.-46C>T 2 upstream_gene_variant 3066237 0 0 0 0 8 5 9473 35700 0.000843792848855605 0.000364358012393849 0.00166192766222289 0.999859963590533 0.999673232250017 0.999954529045718 0.615384615384615 0.315777602914063 0.861420661109839 NA NA NA 0 0 0.521823750104981 NA NA NA NA 4198 4975 False False 6.02976881663675 1.73870529312095 23.4299427777088 0 0 0.000389334034028122 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 8 5 6552 26500 0.00121951219512195 0.000526641184096925 0.00240150352406598 0.999811356347858 0.999559824020536 0.9999387451734 0.615384615384615 0.315777602914063 0.861420661109839 NA NA NA 0 0 0.521823750104981 NA NA NA NA 3475 4087 False False 0 0 0 0 0 0 0 6.47130647130647 1.86575696279097 25.1477150000082 0 0 0.000562857326050777 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c c.477T>C Rv2752c_c.477T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 31 9479 35674 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999131774261308 0.998767847272761 0.999410008882762 0.0606060606060606 0.0074258377422598 0.202264312526355 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.242804978066966 0.0281520979345133 0.954561734783284 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 23 6559 26482 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.99913223920015 0.998698215498625 0.999449837068455 0.0416666666666666 0.00105435244546974 0.211201683456973 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.17554372684065 0.00426447449683549 1.0814738397624999 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.-47C>T Rv2752c_c.-47C>T 2 upstream_gene_variant 3066238 0 0 0 0 8 5 9473 35700 0.000843792848855605 0.000364358012393849 0.00166192766222289 0.999859963590533 0.999673232250017 0.999954529045718 0.615384615384615 0.315777602914063 0.861420661109839 NA NA NA 0 0 0.521823750104981 NA NA NA NA 4481 4975 False False 6.02976881663675 1.73870529312095 23.4299427777088 0 0 0.000389334034028122 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 8 5 6552 26500 0.00121951219512195 0.000526641184096925 0.00240150352406598 0.999811356347858 0.999559824020536 0.9999387451734 0.615384615384615 0.315777602914063 0.861420661109839 NA NA NA 0 0 0.521823750104981 NA NA NA NA 3698 4087 False False 0 0 0 0 0 0 0 6.47130647130647 1.86575696279097 25.1477150000082 0 0 0.000562857326050777 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c c.480C>G Rv2752c_c.480C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.480C>T Rv2752c_c.480C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.88306962025316 0.0319145727646777 36.1783621216076 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.496C>T Rv2752c_c.496C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.498G>C Rv2752c_c.498G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.-50C>A Rv2752c_c.-50C>A 2 upstream_gene_variant 3066241 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c c.513C>T Rv2752c_c.513C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.528G>A Rv2752c_c.528G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.549C>T Rv2752c_c.549C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.54C>T Rv2752c_c.54C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.553C>T Rv2752c_c.553C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.558G>T Rv2752c_c.558G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.561C>A Rv2752c_c.561C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.567G>A Rv2752c_c.567G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.576C>G Rv2752c_c.576C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.576C>T Rv2752c_c.576C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 10 55 9471 35650 0.0010547410610695 0.00050590153672643 0.00193884812290577 0.998459599495868 0.997995422923695 0.99883935521482 0.153846153846153 0.0763215784000004 0.264783508599412 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.684385828509997 0.310896776282795 1.35630574803935 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 7 42 6553 26463 0.0010670731707317 0.000429122972600259 0.00219733487653492 0.998415393322014 0.997858669093897 0.998857723591602 0.142857142857142 0.059421505690313 0.272421512695597 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.673050511216236 0.255003199008683 1.51296973171794 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.585C>T Rv2752c_c.585C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 4 9478 35701 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999887970872426 0.999713186009257 0.999969475016731 0.428571428571428 0.0989882784425078 0.815948432359917 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.82504220299641 0.41374306608866 16.6996717858556 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 4 6558 26501 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999849085078287 0.999613643356053 0.999958879281354 0.333333333333333 0.0432718682927417 0.777221904496487 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.02050930161634 0.182720640564327 14.1017085588021 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.588G>A Rv2752c_c.588G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.594G>A Rv2752c_c.594G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.598C>T Rv2752c_c.598C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 2 9478 35703 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999943985436213 0.999797670939776 0.99999321630447 0.6 0.146632799634673 0.947255049473683 NA NA NA NA NA NA NA NA NA NA NA NA False False 5.65040092846592 0.647137685918782 67.7491623796885 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.-5C>G Rv2752c_c.-5C>G 2 upstream_gene_variant 3066196 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c c.603C>T Rv2752c_c.603C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 3 9480 35702 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99991597815432 0.999754472342108 0.99998267234027 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.25534458509142 0.0239099774609589 15.6346568618898 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.606C>T Rv2752c_c.606C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.612G>A Rv2752c_c.612G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.633C>A Rv2752c_c.633C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.639A>G Rv2752c_c.639A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.651A>G Rv2752c_c.651A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.654G>A Rv2752c_c.654G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.66C>T Rv2752c_c.66C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.675C>T Rv2752c_c.675C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 93 92 9388 35613 0.00980909186794641 0.00792429696998617 0.0120035135932918 0.997423330065817 0.996840865225292 0.997922350269659 0.502702702702702 0.428418660241087 0.576898759139356 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.83469299383116 2.84054397448613 5.17709797952709 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 20 19 6540 26486 0.00304878048780487 0.00186323828472992 0.00470468586167564 0.999283154121863 0.998880781714398 0.999568358524102 0.512820512820512 0.34780220935734 0.675819219034392 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.26299694189602 2.15816438392382 8.44782028055875 NA NA NA NA NA NA 15 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.684T>C Rv2752c_c.684T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.684T>G Rv2752c_c.684T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.699G>A Rv2752c_c.699G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.69C>T Rv2752c_c.69C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.-6C>T Rv2752c_c.-6C>T 2 upstream_gene_variant 3066197 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c c.708G>A Rv2752c_c.708G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.711T>C Rv2752c_c.711T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.717C>G Rv2752c_c.717C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.720C>T Rv2752c_c.720C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.732G>A Rv2752c_c.732G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.753C>T Rv2752c_c.753C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.76624472573839 0.0479745002090283 294.932792118969 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.756A>C Rv2752c_c.756A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.765G>A Rv2752c_c.765G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.771G>A Rv2752c_c.771G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.777G>A Rv2752c_c.777G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.786C>T Rv2752c_c.786C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.801G>A Rv2752c_c.801G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.804C>T Rv2752c_c.804C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.807C>T Rv2752c_c.807C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.819A>G Rv2752c_c.819A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 7 9481 35698 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.61285174975179 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.828G>C Rv2752c_c.828G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.835C>T Rv2752c_c.835C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.840A>T Rv2752c_c.840A>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.843G>A Rv2752c_c.843G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.846T>G Rv2752c_c.846T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.858C>G Rv2752c_c.858C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.858C>T Rv2752c_c.858C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.861C>T Rv2752c_c.861C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.870C>T Rv2752c_c.870C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.876C>A Rv2752c_c.876C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.87C>T Rv2752c_c.87C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.882G>A Rv2752c_c.882G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.891C>G Rv2752c_c.891C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.891C>T Rv2752c_c.891C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.-8delG Rv2752c_c.-8delG 2 upstream_gene_variant 3066198 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4292 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3555 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c c.918C>A Rv2752c_c.918C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.76624472573839 0.0479745002090283 294.932792118969 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.-937_-936delAG Rv2752c_c.-937_-936delAG 2 upstream_gene_variant 3067126 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c c.-937A>T Rv2752c_c.-937A>T 2 upstream_gene_variant 3067128 1 0 0 0 2 1 9479 35704 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999971992718106 0.999843963402622 0.999999290917266 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 4415 4975 False False 7.53328410169849 0.392120325718966 443.147628387906 0 0 0.000389087642036349 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3652 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c c.942G>A Rv2752c_c.942G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.-944C>T Rv2752c_c.-944C>T 2 upstream_gene_variant 3067135 1 19 0 19 11 41 9470 35664 0.00116021516717645 0.00057931301275248 0.00207499495108562 0.998851701442375 0.998442522346295 0.999175839019405 0.211538461538461 0.110611510310857 0.347037606402153 0 0 0.176466911806965 0 0 0.0860438362940284 0 0 0.807173342326083 0.0205946810872287 67 4975 False False 1.01038967728642 0.468184441522093 2.00260566234113 0 0 0.000389457347082932 0.998851701442375 0.998442522346295 0.999175839019405 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 18 0 18 11 36 6549 26469 0.00167682926829268 0.000837354988859942 0.00299832542833478 0.998641765704584 0.998120122196907 0.999048533698614 0.234042553191489 0.123033463285501 0.380257298123598 0 0 0.185301968137852 0 0 0.0973937559144919 0 0 0.919572397288073 0.0341443341936631 60 4087 False False 0 0 0 0 0 0 0 1.23495953580699 0.566722735106514 2.4813961597421 0 0 0.000563115090054247 0.998641765704584 0.998120122196907 0.999048533698614 6 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c c.-945A>G Rv2752c_c.-945A>G 2 upstream_gene_variant 3067136 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c c.-945delA Rv2752c_c.-945delA 2 upstream_gene_variant 3067135 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c c.-948G>A Rv2752c_c.-948G>A 2 upstream_gene_variant 3067139 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c c.-950A>G Rv2752c_c.-950A>G 2 upstream_gene_variant 3067141 NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4335 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3587 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c c.-951C>T Rv2752c_c.-951C>T 2 upstream_gene_variant 3067142 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c c.-951delC Rv2752c_c.-951delC 2 upstream_gene_variant 3067141 1 10 0 10 1 14 9480 35691 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999607898053494 0.999342206985133 0.999785618166341 0.0666666666666666 0.0016864302413527 0.319484566578303 0 0 0.30849710781876 0 0 0.231635761650116 0 0 1.67995428588023 0.134581641082992 136 4975 False False 0.268919529837251 0.00636280625779473 1.7679218975043 0 0 0.00038904660702099 0.999607898053494 0.999342206985133 0.999785618166341 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 1 9 6559 26496 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999660441426146 0.999355510362951 0.999844720818052 0.1 0.00252857854446178 0.445016117028195 0 0 0.369416647552819 0 0 0.336267116879942 0 0 2.36722545919145 0.369978765148518 223.5 4087 False False 0 0 0 0 0 0 0 0.448848909894801 0.0102423495192947 3.24032619577018 0 0 0.000562256793434776 0.999660441426146 0.999355510362951 0.999844720818052 7 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c c.-960A>G Rv2752c_c.-960A>G 2 upstream_gene_variant 3067151 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c c.-961G>A Rv2752c_c.-961G>A 2 upstream_gene_variant 3067152 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4163 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3447 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c c.966G>A Rv2752c_c.966G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 14 3 9467 35702 0.00147663748549731 0.000807519189222099 0.00247630687876465 0.99991597815432 0.999754472342108 0.99998267234027 0.823529411764705 0.565682127155716 0.962014931929374 NA NA NA NA NA NA NA NA NA NA NA NA False False 17.5989577831766 4.91035440370411 95.5815827310724 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 14 3 6546 26502 0.00213414634146341 0.0011672334829473 0.00357814496544914 0.999886813808715 0.999669257903365 0.999976657677988 0.823529411764705 0.565682127155716 0.962014931929374 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 18.8933699969447 5.26959950175651 102.670166870159 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.-966G>T Rv2752c_c.-966G>T 2 upstream_gene_variant 3067157 1 19 0 19 0 26 9481 35679 0 0 0.00038900558066021 0.999271810670774 0.99893321465683 0.999524269143814 0 0 0.132274604497754 0 0 0.176466911806965 0 0 0.132274604497754 0 0 0.806575763765067 0.0205973807925184 68 4975 False False 0 0 0.573807708101142 0 0 0.00038900558066021 0.999271810670774 0.99893321465683 0.999524269143814 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 17 0 17 0 24 6560 26481 0 0 0.000562171107654053 0.999094510469722 0.998653000996664 0.999419752318005 0 0 0.142473597722525 0 0 0.195064322969093 0 0 0.142473597722525 0 0 0.978569563757648 0.0336567356727361 57 4087 False False 0 0 0 0 0 0 0 0 0 0.67091714745426 0 0 0.000562171107654053 0.999094510469722 0.998653000996664 0.999419752318005 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c c.-967G>A Rv2752c_c.-967G>A 2 upstream_gene_variant 3067158 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c c.978C>T Rv2752c_c.978C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol Rv2752c c.-981A>G Rv2752c_c.-981A>G 2 upstream_gene_variant 3067172 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c deletion Rv2752c_deletion 2 feature_ablation (see "Genomic_coordinates" sheet) NA 0 0 0 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4482 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3699 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c LoF Rv2752c_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 132 2 130 247 256 9234 35449 0.0260521042084168 0.0229392953728914 0.0294604926129421 0.992830135835317 0.991899694080629 0.993679000592264 0.491053677932405 0.446534907289148 0.535678167955636 0.0151515151515151 0.00184021476861516 0.0536599312352604 0.00775193798449612 0.000940178229104417 0.0277205572435483 0.0590609953183052 0.00708039444297971 0.217731478701524 7.21655278804788e-11 11 4975 True False 3.70400109310699 3.09236844937991 4.4355912900193 0.000216543958423559 2.62255538820262e-05 0.000782010015110967 0.992830135835317 0.991899694080629 0.993679000592264 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 103 1 102 183 161 6377 26344 0.0278963414634146 0.0240461497574684 0.0321734843843777 0.993925674401056 0.992915143168555 0.994825487094707 0.531976744186046 0.477713653056596 0.585684729592196 0.00970873786407766 0.000245773753693975 0.0529082867402035 0.00617283950617283 0.00015627055381991 0.0339114789748349 0.0405009424186798 0.00101967647235367 0.230862389973348 1.02891222177724e-08 12 4087 True False 0 0 0 0 0 0 0 4.69559373408123 3.77136604120078 5.85100105844369 0.000156788962057071 3.96954495675261e-06 0.000873259167586693 0.993925674401056 0.992915143168555 0.994825487094707 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala110fs Rv2752c_p.Ala110fs 2 frameshift (see "Genomic_coordinates" sheet) 1 4 0 4 1 6 9480 35699 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99983195630864 0.999634275787128 0.999938328510354 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.602364635616474 0 0 0.4592581264399 0 0 5.70543556794744 0.585901759484847 441.5 4975 False False 0.627619549929676 0.0136468000350686 5.17448319653473 0 0 0.00038904660702099 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala110Ser Rv2752c_p.Ala110Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4324 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3579 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala113Glu Rv2752c_p.Ala113Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala113Gly Rv2752c_p.Ala113Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4171 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3454 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala153Val Rv2752c_p.Ala153Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.10982832991351 0.590980565810755 492 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.40943166615857 0.590385352956204 278 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala155Thr Rv2752c_p.Ala155Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala155Val Rv2752c_p.Ala155Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4305 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3566 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala157_Thr160del Rv2752c_p.Ala157_Thr160del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala206Thr Rv2752c_p.Ala206Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala206Val Rv2752c_p.Ala206Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala20Glu Rv2752c_p.Ala20Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.058895521352 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala20Pro Rv2752c_p.Ala20Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12104088004766 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala20Val Rv2752c_p.Ala20Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala229fs Rv2752c_p.Ala229fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4483 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3700 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala236Val Rv2752c_p.Ala236Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.096562813829025 Inf 0.209821626167397 198.5 4975 False False Inf 0.096562813829025 Inf 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala239Val Rv2752c_p.Ala239Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 146.54949493291 1 1480 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 157.208880998325 1 2276.5 4087 False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 0 0 0.000562256793434776 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala251Val Rv2752c_p.Ala251Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala252dup Rv2752c_p.Ala252dup 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala252Glu Rv2752c_p.Ala252Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 9478 35705 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 1 0.999896689850119 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4199 4975 False False Inf 1.55639137151076 Inf 0 0 0.000389128685709026 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 6557 26505 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 1 0.999860832946126 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3476 4087 False False 0 0 0 0 0 0 0 Inf 1.66990152933523 Inf 0 0 0.000562428243381166 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala252Thr Rv2752c_p.Ala252Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala252Val Rv2752c_p.Ala252Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4293 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3556 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala254dup Rv2752c_p.Ala254dup 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4355 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3602 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 3 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala254Val Rv2752c_p.Ala254Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 3 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala273Thr Rv2752c_p.Ala273Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 1 8 9480 35697 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999775941744853 0.999558563909973 0.999903262744512 0.111111111111111 0.00280913674659921 0.482496514917337 0 0 0.4592581264399 0 0 0.369416647552819 0 0 3.19838522501953 0.354702325761204 299.5 4975 False False 0.47068829113924 0.010610026508271 3.51159115085171 0 0 0.00038904660702099 0.999775941744853 0.999558563909973 0.999903262744512 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 1 8 6559 26497 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999698170156574 0.999405361976814 0.999869682578628 0.111111111111111 0.00280913674659921 0.482496514917337 0 0 0.4592581264399 0 0 0.369416647552819 0 0 3.43192265523431 0.605976153142579 305.5 4087 False False 0 0 0 0 0 0 0 0.504974081414849 0.0113820510464553 3.76768363928727 0 0 0.000562256793434776 0.999698170156574 0.999405361976814 0.999869682578628 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala273Val Rv2752c_p.Ala273Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 108 9481 35597 0 0 0.00038900558066021 0.996975213555524 0.996349200382945 0.997518068906269 0 0 0.0335795502186544 NA NA NA 0 0 0.0335795502186544 NA NA NA NA 4274 4975 False True 0 0 0.130490839806012 0 0 0.00038900558066021 0.996975213555524 0.996349200382945 0.997518068906269 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 108 6560 26397 0 0 0.000562171107654053 0.995925297113752 0.995082528193407 0.996656280195635 0 0 0.0335795502186544 NA NA NA 0 0 0.0335795502186544 NA NA NA NA 3539 4087 False True 1 1 1 0 0 0 0 0 0 0.139871062837718 0 0 0.000562171107654053 0.995925297113752 0.995082528193407 0.996656280195635 NA 5) Not assoc w R New NotAwR yes 5 +Ethambutol Rv2752c p.Ala282Gly Rv2752c_p.Ala282Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala290fs Rv2752c_p.Ala290fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala290Pro Rv2752c_p.Ala290Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala292Asp Rv2752c_p.Ala292Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 2 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala292del Rv2752c_p.Ala292del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala296Val Rv2752c_p.Ala296Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 140 9479 35565 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.996078980534939 0.995374677607322 0.996700584642707 0.0140845070422535 0.00171027371166709 0.0499506330548594 NA NA NA 0 0 0.0260050293512926 NA NA NA NA 4430 4975 False True 0.0535996865251005 0.00643316277117793 0.197344045951193 0 0 0.000389087642036349 0.996078980534939 0.995374677607322 0.996700584642707 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 2 113 6558 26392 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.995736653461611 0.994876493429152 0.996485146499241 0.017391304347826 0.00211315082226153 0.0614123325587228 NA NA NA 0 0 0.0321178557457393 NA NA NA NA 3661 4087 False True 1 1 1 0 0 0 0 0.0712282775614192 0.00851088747957258 0.263455703591442 0 0 0.00056234250533983 0.995736653461611 0.994876493429152 0.996485146499241 35 5) Not assoc w R New NotAwR yes 5 +Ethambutol Rv2752c p.Ala330fs Rv2752c_p.Ala330fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 7 9481 35698 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 4453 4975 False False 0 0 2.61285174975179 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3681 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala347Thr Rv2752c_p.Ala347Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala354Ser Rv2752c_p.Ala354Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala368fs Rv2752c_p.Ala368fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4315 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala376Glu Rv2752c_p.Ala376Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4325 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3580 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala376Gly Rv2752c_p.Ala376Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 8 9481 35697 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 0 0 0.369416647552819 0 0 0.4592581264399 0 0 0.369416647552819 0 0 3.19804752107404 0.354692794889658 274.5 4975 False False 0 0 2.20624116275339 0 0 0.00038900558066021 0.999775941744853 0.999558563909973 0.999903262744512 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 6 6560 26499 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 0 0 0.4592581264399 0 0 0.602364635616474 0 0 0.4592581264399 0 0 6.12057895719864 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 3.43165838346939 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 7 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala376Val Rv2752c_p.Ala376Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4229 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3502 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala378Thr Rv2752c_p.Ala378Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala378Val Rv2752c_p.Ala378Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 5 4 9476 35701 0.000527370530534753 0.000171257241502832 0.00123027414547083 0.999887970872426 0.999713186009257 0.999969475016731 0.555555555555555 0.212008506778868 0.863004337734833 0 0 0.975 0 0 0.602364635616474 0 0 146.603020771832 1 2818.5 4975 False False 4.70939742507387 1.01338649657011 23.7370889289433 0 0 0.000389210799037296 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3705 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 3 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala405fs Rv2752c_p.Ala405fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala411Val Rv2752c_p.Ala411Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4284 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3549 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 2 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala423fs Rv2752c_p.Ala423fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala433Ser Rv2752c_p.Ala433Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4263 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3530 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala436Asp Rv2752c_p.Ala436Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala436Thr Rv2752c_p.Ala436Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 20.058335224773 1 1480 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 21.5165239024995 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala441Ser Rv2752c_p.Ala441Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.10982832991351 0.590980565810755 492 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.40943166615857 0.590385352956204 278 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala454fs Rv2752c_p.Ala454fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4363 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3609 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala474Thr Rv2752c_p.Ala474Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala474Val Rv2752c_p.Ala474Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 6 1 9475 35704 0.000632844636641704 0.000232277107744303 0.00137692358870305 0.999971992718106 0.999843963402622 0.999999290917266 0.857142857142857 0.421276802956804 0.996389703138099 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 3.76823218997361 0.0479998139744109 295.08802391992 0.375483602773906 327 4975 False False 22.6093931398416 2.74237918665135 1034.18777725506 0.000105529759392148 2.67177861571188e-06 0.000587832373640432 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala489Val Rv2752c_p.Ala489Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala503Gly Rv2752c_p.Ala503Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4404 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3644 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala520Ser Rv2752c_p.Ala520Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4200 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3477 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala521Pro Rv2752c_p.Ala521Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala521Ser Rv2752c_p.Ala521Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 4172 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 3455 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala521Thr Rv2752c_p.Ala521Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4264 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala530fs Rv2752c_p.Ala530fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala530Thr Rv2752c_p.Ala530Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala530Val Rv2752c_p.Ala530Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ala89Glu Rv2752c_p.Ala89Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Arg120fs Rv2752c_p.Arg120fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4383 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3627 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Arg120His Rv2752c_p.Arg120His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Arg17Gly Rv2752c_p.Arg17Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Arg17Trp Rv2752c_p.Arg17Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4182 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Arg224Leu Rv2752c_p.Arg224Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Arg227Gln Rv2752c_p.Arg227Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4373 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3618 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Arg227Gly Rv2752c_p.Arg227Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.10982832991351 0.590980565810755 492 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12104088004766 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Arg227Trp Rv2752c_p.Arg227Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Arg232Gln Rv2752c_p.Arg232Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4454 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Arg244Gln Rv2752c_p.Arg244Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Arg244His Rv2752c_p.Arg244His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Arg244Trp Rv2752c_p.Arg244Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4455 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3682 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Arg257Trp Rv2752c_p.Arg257Trp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4336 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Arg258Gln Rv2752c_p.Arg258Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4240 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3512 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Arg258Leu Rv2752c_p.Arg258Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 11 0 11 2 16 9479 35689 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999551883489707 0.999272388596077 0.99974384169233 0.111111111111111 0.0137512156643644 0.347120438608672 0 0 0.284914152918154 0 0 0.205907214207822 0 0 1.50045336122178 0.135454110189828 148 4975 False False 0.470632450680451 0.0524909354727906 2.00228700338677 0 0 0.000389087642036349 0.999551883489707 0.999272388596077 0.99974384169233 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 2 8 6558 26497 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999698170156574 0.999405361976814 0.999869682578628 0.2 0.0252107263268333 0.556095462307641 0 0 0.4592581264399 0 0 0.369416647552819 0 0 3.43244607153325 0.605964718481679 303 4087 False False 0 0 0 0 0 0 0 1.01010216529429 0.104463368269269 5.06308595441747 0 0 0.00056234250533983 0.999698170156574 0.999405361976814 0.999869682578628 8 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Arg268Cys Rv2752c_p.Arg268Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Arg268His Rv2752c_p.Arg268His 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Arg271Cys Rv2752c_p.Arg271Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Arg280* Rv2752c_p.Arg280* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4258 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Arg29Cys Rv2752c_p.Arg29Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Arg29Gly Rv2752c_p.Arg29Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Arg317Pro Rv2752c_p.Arg317Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4216 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3492 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Arg320_Gly321insMetSerArg Rv2752c_p.Arg320_Gly321insMetSerArg 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Arg320His Rv2752c_p.Arg320His 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Arg320Leu Rv2752c_p.Arg320Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0615661524565 1 2818.5 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Arg320Pro Rv2752c_p.Arg320Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Arg361Gly Rv2752c_p.Arg361Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 17 0 17 2 19 9479 35686 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999467861644027 0.999169124220115 0.999679588507228 0.0952380952380952 0.0117493178844458 0.303774406913924 0 0 0.195064322969093 0 0 0.176466911806965 0 0 0.912565715858046 0.032839188869816 78 4975 False False 0.396288749090787 0.0447543210266735 1.64316212369714 0 0 0.000389087642036349 0.999467861644027 0.999169124220115 0.999679588507228 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 17 0 17 2 19 6558 26486 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999283154121863 0.998880781714398 0.999568358524102 0.0952380952380952 0.0117493178844458 0.303774406913924 0 0 0.195064322969093 0 0 0.176466911806965 0 0 0.979052951524566 0.0336702803014139 59 4087 False False 0 0 0 0 0 0 0 0.425129612686794 0.0480084870396489 1.762930067696 0 0 0.00056234250533983 0.999283154121863 0.998880781714398 0.999568358524102 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Arg361Ser Rv2752c_p.Arg361Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4265 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3531 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Arg369fs Rv2752c_p.Arg369fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4173 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3456 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Arg389Gly Rv2752c_p.Arg389Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4266 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3532 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Arg389Trp Rv2752c_p.Arg389Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4416 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Arg391fs Rv2752c_p.Arg391fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 2 1 9479 35704 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999971992718106 0.999843963402622 0.999999290917266 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 4217 4975 False False 7.53328410169849 0.392120325718966 443.147628387906 0 0 0.000389087642036349 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Arg391Ser Rv2752c_p.Arg391Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Arg39fs Rv2752c_p.Arg39fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 157.21479794295 1 1103 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Arg39* Rv2752c_p.Arg39* 2 stop_gained (see "Genomic_coordinates" sheet) 1 2 0 2 3 2 9478 35703 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999943985436213 0.999797670939776 0.99999321630447 0.6 0.146632799634673 0.947255049473683 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0657881638833 1 2818.5 4975 False False 5.65040092846592 0.647137685918782 67.7491623796885 0 0 0.000389128685709026 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 6558 26504 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999962271269571 0.999789807096406 0.999999044791703 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 157.238712024072 1 1103 4087 False False 0 0 0 0 0 0 0 8.08295211954864 0.420719628662148 475.373667785977 0 0 0.00056234250533983 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Arg401Gly Rv2752c_p.Arg401Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Arg404Ser Rv2752c_p.Arg404Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Arg465Leu Rv2752c_p.Arg465Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4337 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3588 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Arg465Trp Rv2752c_p.Arg465Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 4 8 9477 35697 0.000421896424427802 0.000114964157806894 0.00107986688593449 0.999775941744853 0.999558563909973 0.999903262744512 0.333333333333333 0.0992460911495833 0.651124493581186 0 0 0.521823750104981 0 0 0.369416647552819 0 0 4.11121772134145 0.59097378854038 462.5 4975 False False 1.88334916112693 0.414922500512465 7.03130983507434 0 0 0.000389169738041761 0.999775941744853 0.999558563909973 0.999903262744512 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 2 3 6558 26502 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999886813808715 0.999669257903365 0.999976657677988 0.4 0.0527449505263169 0.853367200365326 0 0 0.841886116991581 0 0 0.707598226178713 0 0 21.5238846974293 1 1103 4087 False False 0 0 0 0 0 0 0 2.69411405916437 0.224966079471659 23.5225659748306 0 0 0.00056234250533983 0.999886813808715 0.999669257903365 0.999976657677988 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Arg481His Rv2752c_p.Arg481His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4338 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3589 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Arg495dup Rv2752c_p.Arg495dup 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4356 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Arg528Gln Rv2752c_p.Arg528Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4348 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Arg534fs Rv2752c_p.Arg534fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4357 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3603 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Arg535Cys Rv2752c_p.Arg535Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 3 11 9478 35694 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999691919899173 0.999448826618347 0.999846197812 0.214285714285714 0.0465792878898673 0.507975677048471 NA NA NA 0 0 0.284914152918154 NA NA NA NA 4431 4975 False False 1.0270866504249 0.183946304787689 3.88915767329188 0 0 0.000389128685709026 0.999691919899173 0.999448826618347 0.999846197812 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 3 10 6557 26495 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 0.999622712695717 0.999306265033238 0.999819061720012 0.23076923076923 0.0503810734911515 0.53813153923404 NA NA NA 0 0 0.30849710781876 NA NA NA NA 3662 4087 False False 0 0 0 0 0 0 0 1.21221595241726 0.214314396732616 4.70983259529179 0 0 0.000562428243381166 0.999622712695717 0.999306265033238 0.999819061720012 6 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Arg547fs Rv2752c_p.Arg547fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4230 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3503 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Arg547His Rv2752c_p.Arg547His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4275 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3540 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Arg65His Rv2752c_p.Arg65His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Arg65Ser Rv2752c_p.Arg65Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Arg97fs Rv2752c_p.Arg97fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 3 4 9478 35701 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999887970872426 0.999713186009257 0.999969475016731 0.428571428571428 0.0989882784425078 0.815948432359917 0 0 0.841886116991581 0 0 0.602364635616474 0 0 20.0646672123049 1 1480 4975 False False 2.82504220299641 0.41374306608866 16.6996717858556 0 0 0.000389128685709026 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 157.21479794295 1 1103 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Arg97Gln Rv2752c_p.Arg97Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Arg97* Rv2752c_p.Arg97* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 2 2 9479 35703 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999943985436213 0.999797670939776 0.99999321630447 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 146.564919965648 1 1480 4975 False False 3.76653655448887 0.272970929153834 51.9466713138689 0 0 0.000389087642036349 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asn269Asp Rv2752c_p.Asn269Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asn30Asp Rv2752c_p.Asn30Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 1 9478 35704 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999971992718106 0.999843963402622 0.999999290917266 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 146.584444274952 1 1480 4975 False False 11.3011183794049 0.90722384791697 591.183089908516 0 0 0.000389128685709026 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 1 6557 26504 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 0.999962271269571 0.999789807096406 0.999999044791703 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 157.262633381485 1 1103 4087 False False 0 0 0 0 0 0 0 12.1262772609425 0.973374031902014 634.171386087929 0 0 0.000562428243381166 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asn30His Rv2752c_p.Asn30His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4349 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3597 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asn30Lys Rv2752c_p.Asn30Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 6 1 9475 35704 0.000632844636641704 0.000232277107744303 0.00137692358870305 0.999971992718106 0.999843963402622 0.999999290917266 0.857142857142857 0.421276802956804 0.996389703138099 0 0 0.975 0 0 0.975 0 0 146.630749901502 1 2818.5 4975 False False 22.6093931398416 2.74237918665135 1034.18777725506 0 0 0.000389251868698371 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 6 0 6554 26505 0.000914634146341463 0.000335726224038477 0.00198970246660848 1 0.999860832946126 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 3673 4087 False False 0 0 0 0 0 0 0 Inf 4.75965536954277 Inf 0 0 0.000562685614442453 1 0.999860832946126 1 7 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asn30Ser Rv2752c_p.Asn30Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 14 9481 35691 0 0 0.00038900558066021 0.999607898053494 0.999342206985133 0.999785618166341 0 0 0.231635761650116 0 0 0.841886116991581 0 0 0.231635761650116 0 0 20.0527322676307 1 1480 4975 False False 0 0 1.13511057396106 0 0 0.00038900558066021 0.999607898053494 0.999342206985133 0.999785618166341 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 11 6560 26494 0 0 0.000562171107654053 0.999584983965289 0.999257543293353 0.999792807866341 0 0 0.284914152918154 NA NA NA 0 0 0.284914152918154 NA NA NA NA 3448 4087 False False 0 0 0 0 0 0 0 0 0 1.60965686204705 0 0 0.000562171107654053 0.999584983965289 0.999257543293353 0.999792807866341 8 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asn30Tyr Rv2752c_p.Asn30Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4285 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asn344fs Rv2752c_p.Asn344fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4286 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asn386Asp Rv2752c_p.Asn386Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4211 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3488 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asn392fs Rv2752c_p.Asn392fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4405 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asn406Ser Rv2752c_p.Asn406Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 146.54949493291 1 1480 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asn425Lys Rv2752c_p.Asn425Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asn522Asp Rv2752c_p.Asn522Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asn522fs Rv2752c_p.Asn522fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4443 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3674 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asp152Ala Rv2752c_p.Asp152Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 1 5 9480 35700 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999859963590533 0.999673232250017 0.999954529045718 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.602364635616474 0 0 0.521823750104981 0 0 5.70559538331064 0.585903624207148 445 4975 False False 0.753164556962025 0.0159260191955521 6.73154939272228 0 0 0.00038904660702099 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3567 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asp152fs Rv2752c_p.Asp152fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4393 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asp170Asn Rv2752c_p.Asp170Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 16 0 16 2 18 9479 35687 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.99949586892592 0.999203372130377 0.999701193476901 0.1 0.0123485271702948 0.316982714019082 0 0 0.205907214207822 0 0 0.185301968137852 0 0 0.97644682820872 0.0325333984403736 76 4975 False False 0.418316512524762 0.0470668415896743 1.74779566238141 0 0 0.000389087642036349 0.99949586892592 0.999203372130377 0.999701193476901 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 12 0 12 2 13 6558 26492 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999509526504433 0.999161421428146 0.999738818498366 0.133333333333333 0.0165759134400836 0.404602696603372 0 0 0.264648469397051 0 0 0.24705263800047 0 0 1.45425599989063 0.140753590879171 110 4087 False False 0 0 0 0 0 0 0 0.621484035939662 0.0680730148097731 2.74624536978086 0 0 0.00056234250533983 0.999509526504433 0.999161421428146 0.999738818498366 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asp170fs Rv2752c_p.Asp170fs 2 frameshift (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12104088004766 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asp170Gly Rv2752c_p.Asp170Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 5 0 9476 35705 0.000527370530534753 0.000171257241502832 0.00123027414547083 1 0.999896689850119 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 4218 4975 False False Inf 3.45192218064103 Inf 0 0 0.000389210799037296 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 6557 26505 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 1 0.999860832946126 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3493 4087 False False 0 0 0 0 0 0 0 Inf 1.66990152933523 Inf 0 0 0.000562428243381166 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asp174_Gln175insHis Rv2752c_p.Asp174_Gln175insHis 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.096562813829025 Inf 0.209821626167397 198.5 4975 False False Inf 0.096562813829025 Inf 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.103599830448027 Inf 0.198397096627854 142 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asp174fs Rv2752c_p.Asp174fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4287 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3550 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asp174Glu Rv2752c_p.Asp174Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asp179fs Rv2752c_p.Asp179fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4456 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asp184fs Rv2752c_p.Asp184fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4231 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3504 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asp184Glu Rv2752c_p.Asp184Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4276 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3541 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asp184Gly Rv2752c_p.Asp184Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asp184His Rv2752c_p.Asp184His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4267 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3533 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asp193Asn Rv2752c_p.Asp193Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4374 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asp202Ala Rv2752c_p.Asp202Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.11527461591697 1 2818.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.77947080093164 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 3 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asp230Gly Rv2752c_p.Asp230Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asp230Tyr Rv2752c_p.Asp230Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4326 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asp250Glu Rv2752c_p.Asp250Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.058895521352 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 21.5173342675905 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asp298fs Rv2752c_p.Asp298fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4384 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3628 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asp332fs Rv2752c_p.Asp332fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4306 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3568 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asp332Gly Rv2752c_p.Asp332Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 4 4 9477 35701 0.000421896424427802 0.000114964157806894 0.00107986688593449 0.999887970872426 0.999713186009257 0.999969475016731 0.5 0.157012770487058 0.842987229512941 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4432 4975 False False 3.76712039675002 0.701511118396156 20.2258787305262 0 0 0.000389169738041761 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 4 2 6556 26503 0.000609756097560975 0.000166162208307701 0.00156047520083291 0.999924542539143 0.999727448570663 0.999990861620785 0.666666666666666 0.222778095503512 0.956728131707258 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3663 4087 False False 0 0 0 0 0 0 0 8.08511287370347 1.15836227865438 89.5071964701702 0 0 0.000562514007570737 0.999924542539143 0.999727448570663 0.999990861620785 3 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asp332Tyr Rv2752c_p.Asp332Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4417 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asp430Ala Rv2752c_p.Asp430Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4201 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asp44Ala Rv2752c_p.Asp44Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 1 9479 35704 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999971992718106 0.999843963402622 0.999999290917266 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 4307 4975 False False 7.53328410169849 0.392120325718966 443.147628387906 0 0 0.000389087642036349 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asp44Glu Rv2752c_p.Asp44Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4268 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3534 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asp44Gly Rv2752c_p.Asp44Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4232 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3505 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asp450Gly Rv2752c_p.Asp450Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 3 2 9478 35703 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999943985436213 0.999797670939776 0.99999321630447 0.6 0.146632799634673 0.947255049473683 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4308 4975 False False 5.65040092846592 0.647137685918782 67.7491623796885 0 0 0.000389128685709026 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3569 4087 False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 0 0 0.000562256793434776 0.999924542539143 0.999727448570663 0.999990861620785 11 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asp4fs Rv2752c_p.Asp4fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asp500fs Rv2752c_p.Asp500fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 9478 35705 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 1 0.999896689850119 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4484 4975 False False Inf 1.55639137151076 Inf 0 0 0.000389128685709026 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 6557 26505 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 1 0.999860832946126 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3701 4087 False False 0 0 0 0 0 0 0 Inf 1.66990152933523 Inf 0 0 0.000562428243381166 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asp58Glu Rv2752c_p.Asp58Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4375 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3619 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asp63Ala Rv2752c_p.Asp63Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4219 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asp63Gly Rv2752c_p.Asp63Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 1 5 9480 35700 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999859963590533 0.999673232250017 0.999954529045718 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.11026191518576 0.590978447004432 468.5 4975 False False 0.753164556962025 0.0159260191955521 6.73154939272228 0 0 0.00038904660702099 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 3 6559 26502 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999886813808715 0.999669257903365 0.999976657677988 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.78133043653875 1 2276.5 4087 False False 0 0 0 0 0 0 0 1.34685165421558 0.025651688752077 16.7753654027497 0 0 0.000562256793434776 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asp69Asn Rv2752c_p.Asp69Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4277 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3542 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asp72fs Rv2752c_p.Asp72fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 2 2 9479 35703 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999943985436213 0.999797670939776 0.99999321630447 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4457 4975 False False 3.76653655448887 0.272970929153834 51.9466713138689 0 0 0.000389087642036349 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 2 6558 26503 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999924542539143 0.999727448570663 0.999990861620785 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3683 4087 False False 0 0 0 0 0 0 0 4.04132357426044 0.292866339798886 55.7129032982466 0 0 0.00056234250533983 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asp72Glu Rv2752c_p.Asp72Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4394 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asp73Glu Rv2752c_p.Asp73Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4183 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3462 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asp85Ala Rv2752c_p.Asp85Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 9478 35705 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 1 0.999896689850119 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4241 4975 False False Inf 1.55639137151076 Inf 0 0 0.000389128685709026 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3513 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asp85Asn Rv2752c_p.Asp85Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4364 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3610 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asp85fs Rv2752c_p.Asp85fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4418 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asp85Gly Rv2752c_p.Asp85Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 3 3 9478 35702 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.99991597815432 0.999754472342108 0.99998267234027 0.5 0.118117248757025 0.881882751242974 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4350 4975 False False 3.76682844481958 0.504418797674528 28.1425087484132 0 0 0.000389128685709026 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 3 3 6557 26502 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 0.999886813808715 0.999669257903365 0.999976657677988 0.5 0.118117248757025 0.881882751242974 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3598 4087 False False 0 0 0 0 0 0 0 4.04178740277565 0.541216472236634 30.185737988546 0 0 0.000562428243381166 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Asp99Asn Rv2752c_p.Asp99Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4395 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3635 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Cys116Phe Rv2752c_p.Cys116Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 4.10971321225031 0.590981128432313 516.5 4975 False False 0 0 3.19822685561766 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 6 6560 26499 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 4.40926527811573 0.590385229079199 260 4087 False False 0 0 0 0 0 0 0 0 0 3.43165838346939 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Cys141fs Rv2752c_p.Cys141fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4365 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3611 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Cys201Arg Rv2752c_p.Cys201Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 1 9479 35704 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999971992718106 0.999843963402622 0.999999290917266 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 4491 4975 False False 7.53328410169849 0.392120325718966 443.147628387906 0 0 0.000389087642036349 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 1 6558 26504 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999962271269571 0.999789807096406 0.999999044791703 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 3706 4087 False False 0 0 0 0 0 0 0 8.08295211954864 0.420719628662148 475.373667785977 0 0 0.00056234250533983 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Cys201fs Rv2752c_p.Cys201fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Cys201* Rv2752c_p.Cys201* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4396 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3636 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Cys201Tyr Rv2752c_p.Cys201Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Cys237Arg Rv2752c_p.Cys237Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4339 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Cys45* Rv2752c_p.Cys45* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4340 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3590 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Cys45Tyr Rv2752c_p.Cys45Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4358 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3604 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gln132fs Rv2752c_p.Gln132fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gln132Pro Rv2752c_p.Gln132Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 2 5 9479 35700 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999859963590533 0.999673232250017 0.999954529045718 0.285714285714285 0.0366925661760855 0.709579136262657 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.1106955919623 0.590976331736624 466 4975 False False 1.50648802616309 0.143410178089837 9.20379905242336 0 0 0.000389087642036349 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gln132* Rv2752c_p.Gln132* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gln175His Rv2752c_p.Gln175His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4202 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3478 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gln175* Rv2752c_p.Gln175* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gln246Arg Rv2752c_p.Gln246Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4366 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3612 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gln246Pro Rv2752c_p.Gln246Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4465 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3687 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gln246* Rv2752c_p.Gln246* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 6 1 9475 35704 0.000632844636641704 0.000232277107744303 0.00137692358870305 0.999971992718106 0.999843963402622 0.999999290917266 0.857142857142857 0.421276802956804 0.996389703138099 NA NA NA 0 0 0.975 NA NA NA NA 4419 4975 False False 22.6093931398416 2.74237918665135 1034.18777725506 0 0 0.000389251868698371 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 6 0 6554 26505 0.000914634146341463 0.000335726224038477 0.00198970246660848 1 0.999860832946126 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 3653 4087 False False 0 0 0 0 0 0 0 Inf 4.75965536954277 Inf 0 0 0.000562685614442453 1 0.999860832946126 1 4 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gln247* Rv2752c_p.Gln247* 2 stop_gained (see "Genomic_coordinates" sheet) 1 19 1 18 34 53 9447 35652 0.00358611960763632 0.00248473185647407 0.00500767053673668 0.998515614059655 0.998058830612361 0.998887901464271 0.390804597701149 0.287920681458615 0.501344707317215 0.0526315789473684 0.00133162880417942 0.260280654195214 0.0185185185185185 0.00046873840381796 0.0989151595078512 0.209660915281747 0.00503522770068611 1.3282658684209 0.152588544016908 157 4975 False False 2.42099019155527 1.52492332513572 3.79644482782016 0.00010584250635055 2.6796966619657e-06 0.000589574046426996 0.998515614059655 0.998058830612361 0.998887901464271 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 17 1 16 19 25 6541 26480 0.00289634146341463 0.00174465970818583 0.00451931679095641 0.999056781739294 0.998607936501749 0.999389508781733 0.431818181818181 0.283493728089286 0.589662783893966 0.0588235294117647 0.00148817439126663 0.28688939666722 0.0384615384615384 0.00097328789333503 0.196369646762539 0.253019415991438 0.00603619119547259 1.62928188299978 0.223645991946927 171 4087 False False 0 0 0 0 0 0 0 3.07671609845589 1.60062612202348 5.82100310536223 0.000152858453072454 3.87003347506513e-06 0.00085137526882797 0.999056781739294 0.998607936501749 0.999389508781733 11 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gln275Arg Rv2752c_p.Gln275Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4376 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gln275* Rv2752c_p.Gln275* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gln299Arg Rv2752c_p.Gln299Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gln308Glu Rv2752c_p.Gln308Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4220 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3494 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gln308His Rv2752c_p.Gln308His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 146.529978407112 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 157.179059039538 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gln308Pro Rv2752c_p.Gln308Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 3 9480 35702 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99991597815432 0.999754472342108 0.99998267234027 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.0610057960224 1 2818.5 4975 False False 1.25534458509142 0.0239099774609589 15.6346568618898 0 0 0.00038904660702099 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 157.208880998325 1 2276.5 4087 False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 0 0 0.000562256793434776 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gln308* Rv2752c_p.Gln308* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 2 2 9479 35703 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999943985436213 0.999797670939776 0.99999321630447 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 146.564919965648 1 1480 4975 False False 3.76653655448887 0.272970929153834 51.9466713138689 0 0 0.000389087642036349 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 1 6558 26504 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999962271269571 0.999789807096406 0.999999044791703 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 3479 4087 False False 0 0 0 0 0 0 0 8.08295211954864 0.420719628662148 475.373667785977 0 0 0.00056234250533983 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gln367Pro Rv2752c_p.Gln367Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 2 9478 35703 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999943985436213 0.999797670939776 0.99999321630447 0.6 0.146632799634673 0.947255049473683 0 0 0.975 0 0 0.841886116991581 0 0 146.580348245845 1 1480 4975 False False 5.65040092846592 0.647137685918782 67.7491623796885 0 0 0.000389128685709026 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 1 6557 26504 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 0.999962271269571 0.999789807096406 0.999999044791703 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 157.262633381485 1 1103 4087 False False 0 0 0 0 0 0 0 12.1262772609425 0.973374031902014 634.171386087929 0 0 0.000562428243381166 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gln367* Rv2752c_p.Gln367* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4466 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gln417* Rv2752c_p.Gln417* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 9479 35704 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999971992718106 0.999843963402622 0.999999290917266 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 146.569015564619 1 2818.5 4975 False False 7.53328410169849 0.392120325718966 443.147628387906 0 0 0.000389087642036349 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3514 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gln485Arg Rv2752c_p.Gln485Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gln485Pro Rv2752c_p.Gln485Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gln531Glu Rv2752c_p.Gln531Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4406 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3645 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gln531Pro Rv2752c_p.Gln531Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4359 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3605 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gln531* Rv2752c_p.Gln531* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4485 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3702 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gln548fs Rv2752c_p.Gln548fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4327 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Glu114Gly Rv2752c_p.Glu114Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.19822685561766 0.354697857676227 290 4975 False False 0 0 3.19822685561766 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 6560 26499 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.43165838346939 0.605981932438924 311.5 4087 False False 0 0 0 0 0 0 0 0 0 3.43165838346939 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Glu130Lys Rv2752c_p.Glu130Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4433 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3664 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Glu140fs Rv2752c_p.Glu140fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 1 3 9480 35702 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99991597815432 0.999754472342108 0.99998267234027 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.0610057960224 1 2818.5 4975 False False 1.25534458509142 0.0239099774609589 15.6346568618898 0 0 0.00038904660702099 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.5214194708504 1 2276.5 4087 False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 0 0 0.000562256793434776 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Glu142Gly Rv2752c_p.Glu142Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4444 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Glu142* Rv2752c_p.Glu142* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 157.21479794295 1 1103 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Glu207Lys Rv2752c_p.Glu207Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Glu207* Rv2752c_p.Glu207* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4445 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Glu217Asp Rv2752c_p.Glu217Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Glu217* Rv2752c_p.Glu217* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4492 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3707 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Glu26Gly Rv2752c_p.Glu26Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Glu310Ala Rv2752c_p.Glu310Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Glu310fs Rv2752c_p.Glu310fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4397 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3637 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Glu322* Rv2752c_p.Glu322* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Glu345Lys Rv2752c_p.Glu345Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4446 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3675 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Glu345* Rv2752c_p.Glu345* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4294 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3557 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Glu346fs Rv2752c_p.Glu346fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4269 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3535 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Glu35Asp Rv2752c_p.Glu35Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4184 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Glu35fs Rv2752c_p.Glu35fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4398 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3638 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Glu380Ala Rv2752c_p.Glu380Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Glu380Lys Rv2752c_p.Glu380Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4203 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3480 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Glu380* Rv2752c_p.Glu380* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Glu424Gly Rv2752c_p.Glu424Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Glu464Gly Rv2752c_p.Glu464Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4467 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Glu464Lys Rv2752c_p.Glu464Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4185 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3463 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Glu499fs Rv2752c_p.Glu499fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 5 1 9476 35704 0.000527370530534753 0.000171257241502832 0.00123027414547083 0.999971992718106 0.999843963402622 0.999999290917266 0.833333333333333 0.358765421002325 0.99578925548551 NA NA NA 0 0 0.975 NA NA NA NA 4221 4975 False False 18.8391726466863 2.10759583522104 886.708306345849 0 0 0.000389210799037296 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 5 1 6555 26504 0.000762195121951219 0.000247527523788107 0.00177780526826415 0.999962271269571 0.999789807096406 0.999999044791703 0.833333333333333 0.358765421002325 0.99578925548551 NA NA NA 0 0 0.975 NA NA NA NA 3495 4087 False False 0 0 0 0 0 0 0 20.2166285278413 2.26137738039683 951.169010205643 0 0 0.00056259979792051 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Glu499Gly Rv2752c_p.Glu499Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4458 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Glu499* Rv2752c_p.Glu499* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Glu505Gln Rv2752c_p.Glu505Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4468 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3688 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Glu516* Rv2752c_p.Glu516* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4328 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Glu543fs Rv2752c_p.Glu543fs 2 frameshift (see "Genomic_coordinates" sheet) 1 4 0 4 6 9 9475 35696 0.000632844636641704 0.000232277107744303 0.00137692358870305 0.99974793446296 0.999521555266748 0.999884733314884 0.4 0.163364323859513 0.677130233793718 0 0 0.602364635616474 0 0 0.336267116879942 0 0 5.70796700180863 0.585931302440827 456 4975 False False 2.51159190853122 0.735422875844227 7.90310445211299 0 0 0.000389251868698371 0.99974793446296 0.999521555266748 0.999884733314884 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 5 3 6555 26502 0.000762195121951219 0.000247527523788107 0.00177780526826415 0.999886813808715 0.999669257903365 0.999976657677988 0.625 0.244863216366551 0.914766585862746 0 0 0.975 0 0 0.707598226178713 0 0 157.298656862332 1 2276.5 4087 False False 0 0 0 0 0 0 0 6.73836765827612 1.31049304610532 43.4121450586851 0 0 0.00056259979792051 0.999886813808715 0.999669257903365 0.999976657677988 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Glu543* Rv2752c_p.Glu543* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4377 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3620 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Glu54Ala Rv2752c_p.Glu54Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 1 6 9480 35699 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99983195630864 0.999634275787128 0.999938328510354 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.521823750104981 0 0 0.4592581264399 0 0 4.11014678537513 0.590979008627141 471.5 4975 False False 0.627619549929676 0.0136468000350686 5.17448319653473 0 0 0.00038904660702099 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12104088004766 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Glu557Gly Rv2752c_p.Glu557Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4242 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3515 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Glu68Asp Rv2752c_p.Glu68Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 15 9481 35690 0 0 0.00038900558066021 0.9995798907716 0.999307188228015 0.999764849596654 0 0 0.218019360910534 0 0 0.4592581264399 0 0 0.218019360910534 0 0 3.19741985100572 0.354675084633227 267 4975 False False 0 0 1.04976500705909 0 0 0.00038900558066021 0.9995798907716 0.999307188228015 0.999764849596654 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 15 6560 26490 0 0 0.000562171107654053 0.999434069043576 0.999066754461952 0.999683219243554 0 0 0.218019360910534 0 0 0.4592581264399 0 0 0.218019360910534 0 0 3.4304929513801 0.606007431158964 329 4087 False False 0 0 0 0 0 0 0 0 0 1.12620234951212 0 0 0.000562171107654053 0.999434069043576 0.999066754461952 0.999683219243554 2 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Glu68* Rv2752c_p.Glu68* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Glu75* Rv2752c_p.Glu75* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4469 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3689 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Glu84Asp Rv2752c_p.Glu84Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4407 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3646 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Glu84Lys Rv2752c_p.Glu84Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4174 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3457 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly104Ala Rv2752c_p.Gly104Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 1 4 9480 35701 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999887970872426 0.999713186009257 0.999969475016731 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.705755198674 0.585905489084247 449.5 4975 False False 0.941482067510548 0.0191153149568561 9.51304376083015 0 0 0.00038904660702099 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.5214194708504 1 2276.5 4087 False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 0 0 0.000562256793434776 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly15Arg Rv2752c_p.Gly15Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly161Arg Rv2752c_p.Gly161Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4309 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly161Cys Rv2752c_p.Gly161Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly161fs Rv2752c_p.Gly161fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4249 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3518 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly161Ser Rv2752c_p.Gly161Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 30 172 9451 35533 0.00316422318320852 0.00213587538117409 0.00451406881492383 0.995182747514353 0.994408754389383 0.995874409693458 0.148514851485148 0.102499931032621 0.205177190070282 NA NA NA 0 0 0.0212186226251259 NA NA NA NA 4470 4975 False True 0.65576301757166 0.429089822851569 0.971273161663646 0 0 0.000390240147376969 0.995182747514353 0.994408754389383 0.995874409693458 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 24 113 6536 26392 0.00365853658536585 0.0023454571752643 0.00543875250351798 0.995736653461611 0.994876493429152 0.996485146499241 0.175182481751824 0.115586303829829 0.24935069778602 NA NA NA 0 0 0.0321178557457393 NA NA NA NA 3690 4087 False True 0 1 1 0 0 0 0 0.857616360308055 0.527299388150994 1.34262469866242 0 0 0.00056423480096967 0.995736653461611 0.994876493429152 0.996485146499241 21 5) Not assoc w R New NotAwR yes 5 +Ethambutol Rv2752c p.Gly163Arg Rv2752c_p.Gly163Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly169Arg Rv2752c_p.Gly169Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4399 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3639 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly169Val Rv2752c_p.Gly169Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4493 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3708 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly180Cys Rv2752c_p.Gly180Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4459 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3684 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly180fs Rv2752c_p.Gly180fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly187Asp Rv2752c_p.Gly187Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4295 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3558 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly210Arg Rv2752c_p.Gly210Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4222 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3496 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly210Asp Rv2752c_p.Gly210Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly210fs Rv2752c_p.Gly210fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly219Ser Rv2752c_p.Gly219Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly228Cys Rv2752c_p.Gly228Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly228fs Rv2752c_p.Gly228fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4186 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3464 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly22Cys Rv2752c_p.Gly22Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly22Ser Rv2752c_p.Gly22Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4486 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly22Val Rv2752c_p.Gly22Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4259 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3525 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly231Val Rv2752c_p.Gly231Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.10982832991351 0.590980565810755 492 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.40943166615857 0.590385352956204 278 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly256fs Rv2752c_p.Gly256fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly256Ser Rv2752c_p.Gly256Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4187 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly256Val Rv2752c_p.Gly256Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly263Asp Rv2752c_p.Gly263Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly263fs Rv2752c_p.Gly263fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly28Cys Rv2752c_p.Gly28Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4460 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly28Ser Rv2752c_p.Gly28Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 13 2 9468 35703 0.00137116337939035 0.000730282374626527 0.00234358976784705 0.999943985436213 0.999797670939776 0.99999321630447 0.866666666666666 0.595397303396627 0.983424086559916 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4223 4975 False False 24.5109315589353 5.54734753057503 222.848574503837 0 0 0.000389539599191658 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 13 2 6547 26503 0.00198170731707317 0.00105558440345171 0.00338639575788259 0.999924542539143 0.999727448570663 0.999990861620785 0.866666666666666 0.595397303396627 0.983424086559916 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3497 4087 False False 0 0 0 0 0 0 0 26.3127386589277 5.95348514992689 238.993487898742 0 0 0.000563287063923973 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly28Val Rv2752c_p.Gly28Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly306Asp Rv2752c_p.Gly306Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4316 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3575 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly321Thr Rv2752c_p.Gly321Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly331fs Rv2752c_p.Gly331fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 1 9479 35704 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999971992718106 0.999843963402622 0.999999290917266 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 4487 4975 False False 7.53328410169849 0.392120325718966 443.147628387906 0 0 0.000389087642036349 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3703 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly331Ser Rv2752c_p.Gly331Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4408 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly331Val Rv2752c_p.Gly331Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly343Cys Rv2752c_p.Gly343Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly350Glu Rv2752c_p.Gly350Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4243 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly374Arg Rv2752c_p.Gly374Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4164 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly374Asp Rv2752c_p.Gly374Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4471 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3691 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly387Arg Rv2752c_p.Gly387Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly38fs Rv2752c_p.Gly38fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4447 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3676 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly38Ser Rv2752c_p.Gly38Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly398Arg Rv2752c_p.Gly398Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly414Asp Rv2752c_p.Gly414Asp 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4385 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3629 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly414Ser Rv2752c_p.Gly414Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 3 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly426Ala Rv2752c_p.Gly426Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly440Ser Rv2752c_p.Gly440Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly445fs Rv2752c_p.Gly445fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 2 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly451Arg Rv2752c_p.Gly451Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4420 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3654 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly451Asp Rv2752c_p.Gly451Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly451Ser Rv2752c_p.Gly451Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 5 0 9476 35705 0.000527370530534753 0.000171257241502832 0.00123027414547083 1 0.999896689850119 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 4341 4975 False False Inf 3.45192218064103 Inf 0 0 0.000389210799037296 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 5 0 6555 26505 0.000762195121951219 0.000247527523788107 0.00177780526826415 1 0.999860832946126 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 3591 4087 False False 0 0 0 0 0 0 0 Inf 3.70403509656001 Inf 0 0 0.00056259979792051 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly458Arg Rv2752c_p.Gly458Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12104088004766 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly458Asp Rv2752c_p.Gly458Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly463Arg Rv2752c_p.Gly463Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly46fs Rv2752c_p.Gly46fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4212 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3489 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly482Val Rv2752c_p.Gly482Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly484Ser Rv2752c_p.Gly484Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4472 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly496Ala Rv2752c_p.Gly496Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.10982832991351 0.590980565810755 492 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.40943166615857 0.590385352956204 278 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 4 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly496Asp Rv2752c_p.Gly496Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly496fs Rv2752c_p.Gly496fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4165 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3449 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly51Ser Rv2752c_p.Gly51Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly542Glu Rv2752c_p.Gly542Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4250 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly56fs Rv2752c_p.Gly56fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 6 6 9475 35699 0.000632844636641704 0.000232277107744303 0.00137692358870305 0.99983195630864 0.999634275787128 0.999938328510354 0.5 0.210944638239296 0.789055361760703 0 0 0.841886116991581 0 0 0.4592581264399 0 0 20.0698819203725 1 2818.5 4975 False False 3.76770448548812 1.00696556191593 14.0966097383566 0 0 0.000389251868698371 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 5 3 6555 26502 0.000762195121951219 0.000247527523788107 0.00177780526826415 0.999886813808715 0.999669257903365 0.999976657677988 0.625 0.244863216366551 0.914766585862746 0 0 0.841886116991581 0 0 0.707598226178713 0 0 21.5337178739152 1 2276.5 4087 False False 0 0 0 0 0 0 0 6.73836765827612 1.31049304610532 43.4121450586851 0 0 0.00056259979792051 0.999886813808715 0.999669257903365 0.999976657677988 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly56Val Rv2752c_p.Gly56Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4409 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3647 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly82Arg Rv2752c_p.Gly82Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly82Glu Rv2752c_p.Gly82Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 1 9478 35704 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999971992718106 0.999843963402622 0.999999290917266 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 146.584444274952 1 1480 4975 False False 11.3011183794049 0.90722384791697 591.183089908516 0 0 0.000389128685709026 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 1 6557 26504 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 0.999962271269571 0.999789807096406 0.999999044791703 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 157.262633381485 1 1103 4087 False False 0 0 0 0 0 0 0 12.1262772609425 0.973374031902014 634.171386087929 0 0 0.000562428243381166 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly88Arg Rv2752c_p.Gly88Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4386 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly88Glu Rv2752c_p.Gly88Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4461 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly88Trp Rv2752c_p.Gly88Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Gly88Val Rv2752c_p.Gly88Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4317 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.His136Asp Rv2752c_p.His136Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.058895521352 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.His148Arg Rv2752c_p.His148Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4378 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3621 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.His148dup Rv2752c_p.His148dup 2 inframe_insertion (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4224 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3498 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.His148Gln Rv2752c_p.His148Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.His148Pro Rv2752c_p.His148Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 9477 35705 0.000421896424427802 0.000114964157806894 0.00107986688593449 1 0.999896689850119 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 4410 4975 False False Inf 2.4863933079676 Inf 0 0 0.000389169738041761 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3648 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.His148Tyr Rv2752c_p.His148Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 3 9480 35702 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99991597815432 0.999754472342108 0.99998267234027 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.0610057960224 1 2818.5 4975 False False 1.25534458509142 0.0239099774609589 15.6346568618898 0 0 0.00038904660702099 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 3 6559 26502 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999886813808715 0.999669257903365 0.999976657677988 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 21.5206089807014 1 2276.5 4087 False False 0 0 0 0 0 0 0 1.34685165421558 0.025651688752077 16.7753654027497 0 0 0.000562256793434776 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.His167Arg Rv2752c_p.His167Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 4 5 9477 35700 0.000421896424427802 0.000114964157806894 0.00107986688593449 0.999859963590533 0.999673232250017 0.999954529045718 0.444444444444444 0.136995662265166 0.787991493221131 0 0 0.841886116991581 0 0 0.521823750104981 0 0 20.066218234887 1 1480 4975 False False 3.01361190250079 0.597848979046568 13.9996935804854 0 0 0.000389169738041761 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 2 5 6558 26500 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999811356347858 0.999559824020536 0.9999387451734 0.285714285714285 0.0366925661760855 0.709579136262657 0 0 0.841886116991581 0 0 0.521823750104981 0 0 21.5222634684269 1 2276.5 4087 False False 0 0 0 0 0 0 0 1.61634644708752 0.15386320830351 9.87586276350829 0 0 0.00056234250533983 0.999811356347858 0.999559824020536 0.9999387451734 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.His167Pro Rv2752c_p.His167Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 157.21479794295 1 1103 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.His223Arg Rv2752c_p.His223Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4387 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3630 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.His223Tyr Rv2752c_p.His223Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 146.529978407112 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3622 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.His323Arg Rv2752c_p.His323Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4175 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3458 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.His36Gln Rv2752c_p.His36Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.His371Arg Rv2752c_p.His371Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.His371Asp Rv2752c_p.His371Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4270 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.His371fs Rv2752c_p.His371fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.His371Tyr Rv2752c_p.His371Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 3 5 9478 35700 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999859963590533 0.999673232250017 0.999954529045718 0.375 0.0852334141372535 0.755136783633448 0.333333333333333 0.00840375865961264 0.905700675949754 0.166666666666666 0.00421074451448947 0.641234578997674 1.88330871491875 0.031918624291133 36.182991137452 0.506596230278388 351 4975 False False 2.25997045790251 0.350887762500293 11.6204549580208 0.000105496360375567 2.67093302808208e-06 0.000587646375974446 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 1 3 6559 26502 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999886813808715 0.999669257903365 0.999976657677988 0.25 0.00630946320970987 0.805879550316756 0.333333333333333 0.00840375865961264 0.905700675949754 0.25 0.00630946320970987 0.805879550316756 2.02027748132337 0.0342384102171395 38.7744276544107 0.484939389651311 242.5 4087 False False 0 0 0 0 0 0 0 1.34685165421558 0.025651688752077 16.7753654027497 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.His375Arg Rv2752c_p.His375Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4166 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.His375fs Rv2752c_p.His375fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4188 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3465 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.His375Tyr Rv2752c_p.His375Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3481 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.His397Arg Rv2752c_p.His397Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 1 4 5 6 9476 35699 0.000527370530534753 0.000171257241502832 0.00123027414547083 0.99983195630864 0.999634275787128 0.999938328510354 0.454545454545454 0.167488094063707 0.766206402340654 0.2 0.00505076337946806 0.716417936118089 0.142857142857142 0.00361029686190058 0.578723197043195 0.941826720135078 0.0191223117981963 9.51652340476712 1 2818.5 4975 False False 3.13942240045026 0.757750943797823 12.3446047679854 0.000105518624037142 2.6714966936852e-06 0.000587770361337447 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 1 4 5 5 6555 26500 0.000762195121951219 0.000247527523788107 0.00177780526826415 0.999811356347858 0.999559824020536 0.9999387451734 0.5 0.187086028447398 0.812913971552601 0.2 0.00505076337946806 0.716417936118089 0.166666666666666 0.00421074451448947 0.641234578997674 1.01067887109077 0.0205193036701707 10.2185474847182 1 2276.5 4087 False False 0 0 0 0 0 0 0 4.04271548436308 0.930054868102617 17.5613448179105 0.000152532031726662 3.86176923405925e-06 0.000849557834692023 0.999811356347858 0.999559824020536 0.9999387451734 5 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.His397Tyr Rv2752c_p.His397Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 146.54949493291 1 1480 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 157.208880998325 1 2276.5 4087 False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 0 0 0.000562256793434776 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.His491_Gln531del Rv2752c_p.His491_Gln531del 2 inframe_deletion (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4448 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.His491fs Rv2752c_p.His491fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4434 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3665 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.His491Tyr Rv2752c_p.His491Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 9 0 9 1 9 9480 35696 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99974793446296 0.999521555266748 0.999884733314884 0.1 0.00252857854446178 0.445016117028195 0 0 0.336267116879942 0 0 0.336267116879942 0 0 1.90806450507518 0.219221837803997 240.5 4975 False False 0.418377871542428 0.00954775074807024 3.01988679231401 0 0 0.00038904660702099 0.99974793446296 0.999521555266748 0.999884733314884 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 1 8 6559 26497 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999698170156574 0.999405361976814 0.999869682578628 0.111111111111111 0.00280913674659921 0.482496514917337 0 0 0.369416647552819 0 0 0.369416647552819 0 0 2.36731479326647 0.369975844634229 221.5 4087 False False 0 0 0 0 0 0 0 0.504974081414849 0.0113820510464553 3.76768363928727 0 0 0.000562256793434776 0.999698170156574 0.999405361976814 0.999869682578628 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.His493Arg Rv2752c_p.His493Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 2 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.His493Pro Rv2752c_p.His493Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 7 9479 35698 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999803949026747 0.999596102051779 0.999921173824063 0.222222222222222 0.0281449734778982 0.600093573716312 0 0 0.975 0 0 0.409616397225003 0 0 146.544441962914 1 2818.5 4975 False False 1.07600259219628 0.109030897238266 5.65147295095111 0 0 0.000389087642036349 0.999803949026747 0.999596102051779 0.999921173824063 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 5 6558 26500 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999811356347858 0.999559824020536 0.9999387451734 0.285714285714285 0.0366925661760855 0.709579136262657 NA NA NA 0 0 0.521823750104981 NA NA NA NA 3482 4087 False False 0 0 0 0 0 0 0 1.61634644708752 0.15386320830351 9.87586276350829 0 0 0.00056234250533983 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.His52Asp Rv2752c_p.His52Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.His66fs Rv2752c_p.His66fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4167 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3450 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.His66Tyr Rv2752c_p.His66Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4421 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3655 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.His81Arg Rv2752c_p.His81Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 2 3 9479 35702 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.99991597815432 0.999754472342108 0.99998267234027 0.4 0.0527449505263169 0.853367200365326 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11745289828119 1 1480 4975 False False 2.51095403875232 0.209684820120099 21.9222407664312 0 0 0.000389087642036349 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 2 3 6558 26502 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999886813808715 0.999669257903365 0.999976657677988 0.4 0.0527449505263169 0.853367200365326 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.78282164268659 1 2276.5 4087 False False 0 0 0 0 0 0 0 2.69411405916437 0.224966079471659 23.5225659748306 0 0 0.00056234250533983 0.999886813808715 0.999669257903365 0.999976657677988 2 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.His81Asp Rv2752c_p.His81Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.His81Pro Rv2752c_p.His81Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4388 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3631 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.His81Tyr Rv2752c_p.His81Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 2 6 9479 35699 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.99983195630864 0.999634275787128 0.999938328510354 0.25 0.0318540262499442 0.650855794412824 0 0 0.841886116991581 0 0 0.4592581264399 0 0 20.0614352707058 1 1480 4975 False False 1.25537152301578 0.123863858669135 7.02323716133577 0 0 0.000389087642036349 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 2 5 6558 26500 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999811356347858 0.999559824020536 0.9999387451734 0.285714285714285 0.0366925661760855 0.709579136262657 0 0 0.841886116991581 0 0 0.521823750104981 0 0 21.5222634684269 1 2276.5 4087 False False 0 0 0 0 0 0 0 1.61634644708752 0.15386320830351 9.87586276350829 0 0 0.00056234250533983 0.999811356347858 0.999559824020536 0.9999387451734 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.His83Arg Rv2752c_p.His83Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 7 9480 35698 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999803949026747 0.999596102051779 0.999921173824063 0.125 0.0031597235312519 0.526509670875206 0 0 0.707598226178713 0 0 0.409616397225003 0 0 9.11547015902471 1 1480 4975 False False 0.53794454490657 0.0119383062528594 4.18812953339448 0 0 0.00038904660702099 0.999803949026747 0.999596102051779 0.999921173824063 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 3 6559 26502 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999886813808715 0.999669257903365 0.999976657677988 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 21.5206089807014 1 2276.5 4087 False False 0 0 0 0 0 0 0 1.34685165421558 0.025651688752077 16.7753654027497 0 0 0.000562256793434776 0.999886813808715 0.999669257903365 0.999976657677988 2 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.His83Asn Rv2752c_p.His83Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.His83Pro Rv2752c_p.His83Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 3 4 9478 35701 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999887970872426 0.999713186009257 0.999969475016731 0.428571428571428 0.0989882784425078 0.815948432359917 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4494 4975 False False 2.82504220299641 0.41374306608866 16.6996717858556 0 0 0.000389128685709026 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 3 2 6557 26503 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 0.999924542539143 0.999727448570663 0.999990861620785 0.6 0.146632799634673 0.947255049473683 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3709 4087 False False 0 0 0 0 0 0 0 6.06290986731737 0.694321240468692 72.4391518330217 0 0 0.000562428243381166 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.His83Tyr Rv2752c_p.His83Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 9479 35704 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999971992718106 0.999843963402622 0.999999290917266 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 146.569015564619 1 2818.5 4975 False False 7.53328410169849 0.392120325718966 443.147628387906 0 0 0.000389087642036349 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 157.21479794295 1 1103 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.His86Arg Rv2752c_p.His86Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 9479 35704 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999971992718106 0.999843963402622 0.999999290917266 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 146.569015564619 1 2818.5 4975 False False 7.53328410169849 0.392120325718966 443.147628387906 0 0 0.000389087642036349 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3710 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.His86fs Rv2752c_p.His86fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4225 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3499 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.His86Tyr Rv2752c_p.His86Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0615661524565 1 2818.5 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.5214194708504 1 2276.5 4087 False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 0 0 0.000562256793434776 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ile121fs Rv2752c_p.Ile121fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4342 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3592 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ile121Met Rv2752c_p.Ile121Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4213 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3490 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ile165fs Rv2752c_p.Ile165fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4310 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3570 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ile165Ser Rv2752c_p.Ile165Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4278 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3543 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ile165Val Rv2752c_p.Ile165Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ile171fs Rv2752c_p.Ile171fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ile234Arg Rv2752c_p.Ile234Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ile234Val Rv2752c_p.Ile234Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ile248Thr Rv2752c_p.Ile248Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ile249Ser Rv2752c_p.Ile249Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ile24Val Rv2752c_p.Ile24Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4251 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3519 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ile303Ser Rv2752c_p.Ile303Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4329 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3581 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ile358dup Rv2752c_p.Ile358dup 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12104088004766 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ile42Asn Rv2752c_p.Ile42Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ile438Thr Rv2752c_p.Ile438Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4330 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3582 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ile43fs Rv2752c_p.Ile43fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4473 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ile43Ser Rv2752c_p.Ile43Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4462 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ile43Val Rv2752c_p.Ile43Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4360 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3606 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ile453Thr Rv2752c_p.Ile453Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ile460Val Rv2752c_p.Ile460Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ile527fs Rv2752c_p.Ile527fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ile527Met Rv2752c_p.Ile527Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ile527Thr Rv2752c_p.Ile527Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4343 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3593 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ile527Val Rv2752c_p.Ile527Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4495 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ile529fs Rv2752c_p.Ile529fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4422 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ile529Ser Rv2752c_p.Ile529Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 3 3 9478 35702 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.99991597815432 0.999754472342108 0.99998267234027 0.5 0.118117248757025 0.881882751242974 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11841471655 1 2818.5 4975 False False 3.76682844481958 0.504418797674528 28.1425087484132 0 0 0.000389128685709026 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 3 3 6557 26502 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 0.999886813808715 0.999669257903365 0.999976657677988 0.5 0.118117248757025 0.881882751242974 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.78431330340966 1 2276.5 4087 False False 0 0 0 0 0 0 0 4.04178740277565 0.541216472236634 30.185737988546 0 0 0.000562428243381166 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ile551Thr Rv2752c_p.Ile551Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ile556Val Rv2752c_p.Ile556Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4435 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3666 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ile60fs Rv2752c_p.Ile60fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4233 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ile87Thr Rv2752c_p.Ile87Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ile90fs Rv2752c_p.Ile90fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu109Trp Rv2752c_p.Leu109Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 3 9480 35702 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99991597815432 0.999754472342108 0.99998267234027 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.0610057960224 1 2818.5 4975 False False 1.25534458509142 0.0239099774609589 15.6346568618898 0 0 0.00038904660702099 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 3 6559 26502 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999886813808715 0.999669257903365 0.999976657677988 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 21.5206089807014 1 2276.5 4087 False False 0 0 0 0 0 0 0 1.34685165421558 0.025651688752077 16.7753654027497 0 0 0.000562256793434776 0.999886813808715 0.999669257903365 0.999976657677988 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu111Arg Rv2752c_p.Leu111Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu111Pro Rv2752c_p.Leu111Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4176 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu11fs Rv2752c_p.Leu11fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4318 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu154* Rv2752c_p.Leu154* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu166Arg Rv2752c_p.Leu166Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4319 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3576 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu166Pro Rv2752c_p.Leu166Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 146.525883667094 1 2818.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu16Phe Rv2752c_p.Leu16Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4189 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3466 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu16Trp Rv2752c_p.Leu16Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu176Ser Rv2752c_p.Leu176Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.975 0 0 0.521823750104981 0 0 146.521788926551 1 1480 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.975 0 0 0.521823750104981 0 0 157.167226939892 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu185Pro Rv2752c_p.Leu185Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 9480 35702 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99991597815432 0.999754472342108 0.99998267234027 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11649128277037 1 2818.5 4975 False False 1.25534458509142 0.0239099774609589 15.6346568618898 0 0 0.00038904660702099 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu191Phe Rv2752c_p.Leu191Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4344 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3594 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu191Pro Rv2752c_p.Leu191Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 146.54949493291 1 1480 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3544 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu199fs Rv2752c_p.Leu199fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4252 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3520 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu199Ser Rv2752c_p.Leu199Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4400 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3640 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu200Arg Rv2752c_p.Leu200Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 157.21479794295 1 1103 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu21Pro Rv2752c_p.Leu21Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4401 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3641 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu222Arg Rv2752c_p.Leu222Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 146.54949493291 1 1480 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 157.208880998325 1 2276.5 4087 False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 0 0 0.000562256793434776 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu222Gln Rv2752c_p.Leu222Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu222Pro Rv2752c_p.Leu222Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3607 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu225His Rv2752c_p.Leu225His 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu225Pro Rv2752c_p.Leu225Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 2 9478 35703 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999943985436213 0.999797670939776 0.99999321630447 0.6 0.146632799634673 0.947255049473683 0 0 0.975 0 0 0.841886116991581 0 0 146.580348245845 1 1480 4975 False False 5.65040092846592 0.647137685918782 67.7491623796885 0 0 0.000389128685709026 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 157.208880998325 1 2276.5 4087 False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 0 0 0.000562256793434776 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu276Pro Rv2752c_p.Leu276Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4279 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3545 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu279Arg Rv2752c_p.Leu279Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4214 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu286Arg Rv2752c_p.Leu286Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4204 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3483 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu302_Thr305del Rv2752c_p.Leu302_Thr305del 2 inframe_deletion (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4436 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3667 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu315* Rv2752c_p.Leu315* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4288 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3551 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu333fs Rv2752c_p.Leu333fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4437 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3668 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu333Pro Rv2752c_p.Leu333Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0615661524565 1 2818.5 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.5214194708504 1 2276.5 4087 False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 0 0 0.000562256793434776 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu336fs Rv2752c_p.Leu336fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu355Arg Rv2752c_p.Leu355Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4311 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3571 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu37Pro Rv2752c_p.Leu37Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 9479 35704 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999971992718106 0.999843963402622 0.999999290917266 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 146.569015564619 1 2818.5 4975 False False 7.53328410169849 0.392120325718966 443.147628387906 0 0 0.000389087642036349 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 6558 26504 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999962271269571 0.999789807096406 0.999999044791703 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 157.238712024072 1 1103 4087 False False 0 0 0 0 0 0 0 8.08295211954864 0.420719628662148 475.373667785977 0 0 0.00056234250533983 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu37Val Rv2752c_p.Leu37Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4331 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3583 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu381Arg Rv2752c_p.Leu381Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 3 9480 35702 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99991597815432 0.999754472342108 0.99998267234027 0.25 0.00630946320970987 0.805879550316756 0 0 0.975 0 0 0.707598226178713 0 0 146.545399763461 1 2818.5 4975 False False 1.25534458509142 0.0239099774609589 15.6346568618898 0 0 0.00038904660702099 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 157.179059039538 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 2 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu382Pro Rv2752c_p.Leu382Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4205 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3484 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu384Arg Rv2752c_p.Leu384Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4177 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3459 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu384His Rv2752c_p.Leu384His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4168 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3451 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu384Val Rv2752c_p.Leu384Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu403Arg Rv2752c_p.Leu403Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4332 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3584 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu403Met Rv2752c_p.Leu403Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4361 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3608 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu40fs Rv2752c_p.Leu40fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu41Ser Rv2752c_p.Leu41Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 146.54949493291 1 1480 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 157.208880998325 1 2276.5 4087 False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 0 0 0.000562256793434776 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu41Trp Rv2752c_p.Leu41Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4320 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu422Phe Rv2752c_p.Leu422Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu431Arg Rv2752c_p.Leu431Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4321 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu452Ser Rv2752c_p.Leu452Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4333 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3585 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 2 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu452Val Rv2752c_p.Leu452Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4488 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3704 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu466Pro Rv2752c_p.Leu466Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4253 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3521 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu468fs Rv2752c_p.Leu468fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4226 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3500 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu468Phe Rv2752c_p.Leu468Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu487Phe Rv2752c_p.Leu487Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 51 1 50 5 74 9476 35631 0.000527370530534753 0.000171257241502832 0.00123027414547083 0.997927461139896 0.997398806120765 0.998372271568651 0.0632911392405063 0.0208679461465618 0.141551582617291 0.0196078431372549 0.000496304407737771 0.104474896395517 0.0133333333333333 0.000337513802521148 0.0720634972431675 0.0752026171380329 0.0018709192251274 0.438777332631999 0.000184332415154713 23 4975 True False 0.254062895736597 0.0800968334486538 0.620267120356304 0.000105518624037142 2.6714966936852e-06 0.000587770361337447 0.997927461139896 0.997398806120765 0.998372271568651 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 45 1 44 4 67 6556 26438 0.000609756097560975 0.000166162208307701 0.00156047520083291 0.997472175061309 0.996790847475922 0.998040449773907 0.056338028169014 0.0155616350412414 0.138011443220829 0.0222222222222222 0.000562459715402258 0.117704331418294 0.0147058823529411 0.00037225140289861 0.079233989912788 0.091650951245216 0.00227306474977561 0.538219684465801 0.00107729309519064 28 4087 False False 0 0 0 0 0 0 0 0.240754737599373 0.0637011968015265 0.646034052559741 0.000152508769254232 3.86118028152325e-06 0.000849428314837321 0.997472175061309 0.996790847475922 0.998040449773907 10 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu48Ser Rv2752c_p.Leu48Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4296 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3559 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu492Arg Rv2752c_p.Leu492Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 2 4 9479 35701 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999887970872426 0.999713186009257 0.999969475016731 0.333333333333333 0.0432718682927417 0.777221904496487 0.333333333333333 0.00840375865961264 0.905700675949754 0.2 0.00505076337946806 0.716417936118089 1.88316278088405 0.0319161513203065 36.180165815097 0.506620292550776 352 4975 False False 1.88316278088405 0.170308362439121 13.1422755166224 0.00010548523206751 2.670651284468e-06 0.000587584402906152 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 2 3 6558 26502 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999886813808715 0.999669257903365 0.999976657677988 0.4 0.0527449505263169 0.853367200365326 0.5 0.012579117093425 0.987420882906574 0.25 0.00630946320970987 0.805879550316756 4.04117108874656 0.0514741251467053 316.404792634386 0.357417965768776 189 4087 False False 0 0 0 0 0 0 0 2.69411405916437 0.224966079471659 23.5225659748306 0.000152462265589266 3.86000291520843e-06 0.000849169393567967 0.999886813808715 0.999669257903365 0.999976657677988 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu504fs Rv2752c_p.Leu504fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4345 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3595 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 4 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu504Pro Rv2752c_p.Leu504Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4206 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3485 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu515Arg Rv2752c_p.Leu515Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4474 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3692 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu5Phe Rv2752c_p.Leu5Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4271 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3536 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu5Val Rv2752c_p.Leu5Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu61Pro Rv2752c_p.Leu61Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 146.54949493291 1 1480 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 157.208880998325 1 2276.5 4087 False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 0 0 0.000562256793434776 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu77Arg Rv2752c_p.Leu77Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4244 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3516 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu77Pro Rv2752c_p.Leu77Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 1.88306962025316 0.0319145727646777 36.1783621216076 0.506635653517051 355 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 2.02035371245616 0.0342397021387091 38.7759303485373 0.484927822237944 240 4087 False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu93Arg Rv2752c_p.Leu93Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 7 3 9474 35702 0.000738318742748655 0.00029689231210758 0.00152062336565454 0.99991597815432 0.999754472342108 0.99998267234027 0.7 0.347547149940002 0.933260488822265 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.12226401848927 1 2818.5 4975 False False 8.79297727112799 2.00679427251216 52.716257751683 0 0 0.000389292947027732 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 6 3 6554 26502 0.000914634146341463 0.000335726224038477 0.00198970246660848 0.999886813808715 0.999669257903365 0.999976657677988 0.666666666666666 0.29929505620854 0.925145368580308 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.78879101511209 1 2276.5 4087 False False 0 0 0 0 0 0 0 8.08727494659749 1.7264855065906 50.0074859620969 0 0 0.000562685614442453 0.999886813808715 0.999669257903365 0.999976657677988 3 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu93fs Rv2752c_p.Leu93fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu93Met Rv2752c_p.Leu93Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 9479 35704 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999971992718106 0.999843963402622 0.999999290917266 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 146.569015564619 1 2818.5 4975 False False 7.53328410169849 0.392120325718966 443.147628387906 0 0 0.000389087642036349 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 157.21479794295 1 1103 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu93Pro Rv2752c_p.Leu93Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4227 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3501 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu94Arg Rv2752c_p.Leu94Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu94Phe Rv2752c_p.Leu94Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4312 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3572 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu94Pro Rv2752c_p.Leu94Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4207 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3486 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Leu96fs Rv2752c_p.Leu96fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Lys106Asn Rv2752c_p.Lys106Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Lys115Glu Rv2752c_p.Lys115Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Lys172Gln Rv2752c_p.Lys172Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 3 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Lys172Glu Rv2752c_p.Lys172Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 2 4 9479 35701 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999887970872426 0.999713186009257 0.999969475016731 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.841886116991581 0 0 0.602364635616474 0 0 20.0625561022088 1 2818.5 4975 False False 1.88316278088405 0.170308362439121 13.1422755166224 0 0 0.000389087642036349 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 2 3 6558 26502 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999886813808715 0.999669257903365 0.999976657677988 0.4 0.0527449505263169 0.853367200365326 0 0 0.841886116991581 0 0 0.707598226178713 0 0 21.5238846974293 1 1103 4087 False False 0 0 0 0 0 0 0 2.69411405916437 0.224966079471659 23.5225659748306 0 0 0.00056234250533983 0.999886813808715 0.999669257903365 0.999976657677988 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Lys172Thr Rv2752c_p.Lys172Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Lys357fs Rv2752c_p.Lys357fs 2 frameshift (see "Genomic_coordinates" sheet) 1 29 0 29 0 32 9481 35673 0 0 0.00038900558066021 0.999103766979414 0.998735019826828 0.999386899029865 0 0 0.108881160679352 0 0 0.119444869069502 0 0 0.108881160679352 0 0 0.51051109651385 0.00205085767883892 35 4975 False False 0 0 0.459859432890119 0 0 0.00038900558066021 0.999103766979414 0.998735019826828 0.999386899029865 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 29 0 29 0 32 6560 26473 0 0 0.000562171107654053 0.998792680626296 0.998296048910783 0.999174052431467 0 0 0.108881160679352 0 0 0.119444869069502 0 0 0.108881160679352 0 0 0.547602554910114 0.00362212840192204 33 4087 False False 0 0 0 0 0 0 0 0 0 0.493260968594333 0 0 0.000562171107654053 0.998792680626296 0.998296048910783 0.999174052431467 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Lys357Thr Rv2752c_p.Lys357Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 10 9481 35695 0 0 0.00038900558066021 0.999719927181067 0.999484996631079 0.999865686288203 0 0 0.30849710781876 NA NA NA 0 0 0.30849710781876 NA NA NA NA 4367 4975 False False 0 0 1.67996531074212 0 0 0.00038900558066021 0.999719927181067 0.999484996631079 0.999865686288203 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 9 6560 26496 0 0 0.000562171107654053 0.999660441426146 0.999355510362951 0.999844720818052 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 3613 4087 False False 0 0 0 0 0 0 0 0 0 2.04691100627475 0 0 0.000562171107654053 0.999660441426146 0.999355510362951 0.999844720818052 5 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Lys408Arg Rv2752c_p.Lys408Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Lys408Asn Rv2752c_p.Lys408Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Lys435Glu Rv2752c_p.Lys435Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 24 0 24 6 43 9475 35662 0.000632844636641704 0.000232277107744303 0.00137692358870305 0.998795686878588 0.998378137129092 0.999128299767525 0.122448979591836 0.0462890310818957 0.247692968359682 0 0 0.142473597722525 0 0 0.0822111211541385 0 0 0.625498838269247 0.00502580742909898 43 4975 False False 0.525181321715653 0.182626219738688 1.23973146209002 0 0 0.000389251868698371 0.998795686878588 0.998378137129092 0.999128299767525 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 21 0 21 5 39 6555 26466 0.000762195121951219 0.000247527523788107 0.00177780526826415 0.998528579513299 0.997989063008624 0.998953473433816 0.113636363636363 0.0379437129392748 0.245576776315531 0 0 0.161097615219079 0 0 0.0902511009603342 0 0 0.775609336567579 0.0134240809383441 45 4087 False False 0 0 0 0 0 0 0 0.517631872322947 0.159179076273111 1.31507027948239 0 0 0.00056259979792051 0.998528579513299 0.997989063008624 0.998953473433816 5 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Lys446fs Rv2752c_p.Lys446fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 2 1 9479 35704 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999971992718106 0.999843963402622 0.999999290917266 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 4475 4975 False False 7.53328410169849 0.392120325718966 443.147628387906 0 0 0.000389087642036349 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 1 6558 26504 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999962271269571 0.999789807096406 0.999999044791703 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 3693 4087 False False 0 0 0 0 0 0 0 8.08295211954864 0.420719628662148 475.373667785977 0 0 0.00056234250533983 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Lys502fs Rv2752c_p.Lys502fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4496 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Lys502Thr Rv2752c_p.Lys502Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Lys510Gln Rv2752c_p.Lys510Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 5 2 9476 35703 0.000527370530534753 0.000171257241502832 0.00123027414547083 0.999943985436213 0.999797670939776 0.99999321630447 0.714285714285714 0.290420863737342 0.963307433823914 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4402 4975 False False 9.4193224989447 1.54161474423025 98.9467001652174 0 0 0.000389210799037296 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 5 2 6555 26503 0.000762195121951219 0.000247527523788107 0.00177780526826415 0.999924542539143 0.999727448570663 0.999990861620785 0.714285714285714 0.290420863737342 0.963307433823914 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3642 4087 False False 0 0 0 0 0 0 0 10.1079328756674 1.6542054319611 106.199585900179 0 0 0.00056259979792051 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Lys539Thr Rv2752c_p.Lys539Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4476 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3694 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Met1? Rv2752c_p.Met1? 2 start_lost (see "Genomic_coordinates" sheet) 1 2 0 2 1 3 9480 35702 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99991597815432 0.999754472342108 0.99998267234027 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.0610057960224 1 2818.5 4975 False False 1.25534458509142 0.0239099774609589 15.6346568618898 0 0 0.00038904660702099 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 21.5173342675905 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 3 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Met188Lys Rv2752c_p.Met188Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 2 6 2 6 9479 35699 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.99983195630864 0.999634275787128 0.999938328510354 0.25 0.0318540262499442 0.650855794412824 0.25 0.0318540262499442 0.650855794412824 0.25 0.0318540262499442 0.650855794412824 1.25537152301578 0.123863858669135 7.02323716133577 0.677128363680903 531 4975 False False 1.25537152301578 0.123863858669135 7.02323716133577 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Met266Thr Rv2752c_p.Met266Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4423 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3656 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Met270Arg Rv2752c_p.Met270Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4322 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3577 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Met312Ile Rv2752c_p.Met312Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 10 0 10 0 10 9481 35695 0 0 0.00038900558066021 0.999719927181067 0.999484996631079 0.999865686288203 0 0 0.30849710781876 0 0 0.30849710781876 0 0 0.30849710781876 0 0 1.67996531074212 0.134582133412278 140.5 4975 False False 0 0 1.67996531074212 0 0 0.00038900558066021 0.999719927181067 0.999484996631079 0.999865686288203 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Met312Val Rv2752c_p.Met312Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 16 0 16 0 18 9481 35687 0 0 0.00038900558066021 0.99949586892592 0.999203372130377 0.999701193476901 0 0 0.185301968137852 0 0 0.205907214207822 0 0 0.185301968137852 0 0 0.976240781066386 0.032526834903596 74 4975 False False 0 0 0.856331153965207 0 0 0.00038900558066021 0.99949586892592 0.999203372130377 0.999701193476901 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 15 0 15 0 16 6560 26489 0 0 0.000562171107654053 0.999396340313148 0.99901987910474 0.999654918214049 0 0 0.205907214207822 0 0 0.218019360910534 0 0 0.205907214207822 0 0 1.12615985462212 0.0535000885137386 70 4087 False False 0 0 0 0 0 0 0 0 0 1.047384092264 0 0 0.000562171107654053 0.999396340313148 0.99901987910474 0.999654918214049 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Met318_Arg320del Rv2752c_p.Met318_Arg320del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 0 0 0 2 3 9479 35702 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.99991597815432 0.999754472342108 0.99998267234027 0.4 0.0527449505263169 0.853367200365326 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4190 4975 False False 2.51095403875232 0.209684820120099 21.9222407664312 0 0 0.000389087642036349 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3467 4087 False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 0 0 0.000562256793434776 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Met31fs Rv2752c_p.Met31fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4254 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3522 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Met31Ile Rv2752c_p.Met31Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 37 287 9444 35418 0.00390254192595717 0.00274919326450094 0.00537516682549457 0.991961910096625 0.990980551568589 0.992861926983495 0.114197530864197 0.0816923970480654 0.153958644069266 NA NA NA 0 0 0.0127709884164097 NA NA NA NA 4389 4975 False True 0.483490430293665 0.333353750565839 0.683090074162258 0 0 0.000390529341316127 0.991961910096625 0.990980551568589 0.992861926983495 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 19 147 6541 26358 0.00289634146341463 0.00174465970818583 0.00451931679095641 0.994453876627051 0.99348453249964 0.995312253544617 0.114457831325301 0.0703352445766835 0.172959405755892 NA NA NA 0 0 0.0247821704895807 NA NA NA NA 3632 4087 False True 0 1 1 0 0 0 0 0.520840288416238 0.304647207488706 0.843505401246111 0 0 0.000563803616355508 0.994453876627051 0.99348453249964 0.995312253544617 53 5) Not assoc w R New NotAwR yes 5 +Ethambutol Rv2752c p.Met394Arg Rv2752c_p.Met394Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 1 9479 35704 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999971992718106 0.999843963402622 0.999999290917266 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 4234 4975 False False 7.53328410169849 0.392120325718966 443.147628387906 0 0 0.000389087642036349 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 1 6558 26504 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999962271269571 0.999789807096406 0.999999044791703 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 3506 4087 False False 0 0 0 0 0 0 0 8.08295211954864 0.420719628662148 475.373667785977 0 0 0.00056234250533983 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Met394fs Rv2752c_p.Met394fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4424 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3657 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Met394Thr Rv2752c_p.Met394Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Met447Thr Rv2752c_p.Met447Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 3 9480 35702 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99991597815432 0.999754472342108 0.99998267234027 0.25 0.00630946320970987 0.805879550316756 0 0 0.975 0 0 0.707598226178713 0 0 146.545399763461 1 2818.5 4975 False False 1.25534458509142 0.0239099774609589 15.6346568618898 0 0 0.00038904660702099 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 157.208880998325 1 2276.5 4087 False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 0 0 0.000562256793434776 0.999924542539143 0.999727448570663 0.999990861620785 3 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Met550dup Rv2752c_p.Met550dup 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Met64Arg Rv2752c_p.Met64Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Met64Ile Rv2752c_p.Met64Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4368 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3614 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Phe107Pro Rv2752c_p.Phe107Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4477 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3695 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Phe107Ser Rv2752c_p.Phe107Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4346 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3596 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Phe107Val Rv2752c_p.Phe107Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4313 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3573 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Phe125Leu Rv2752c_p.Phe125Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4463 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3685 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Phe139fs Rv2752c_p.Phe139fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4411 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3649 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Phe139Leu Rv2752c_p.Phe139Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Phe139Val Rv2752c_p.Phe139Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4178 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Phe144dup Rv2752c_p.Phe144dup 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Phe144Ser Rv2752c_p.Phe144Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4425 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3658 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Phe238Ser Rv2752c_p.Phe238Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 3 9480 35702 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99991597815432 0.999754472342108 0.99998267234027 0.25 0.00630946320970987 0.805879550316756 0 0 0.975 0 0 0.707598226178713 0 0 146.545399763461 1 2818.5 4975 False False 1.25534458509142 0.0239099774609589 15.6346568618898 0 0 0.00038904660702099 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3552 4087 False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 0 0 0.000562256793434776 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Phe349fs Rv2752c_p.Phe349fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4497 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Phe34fs Rv2752c_p.Phe34fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4235 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3507 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Phe383Leu Rv2752c_p.Phe383Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 157.21479794295 1 1103 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Phe383Val Rv2752c_p.Phe383Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Phe448Leu Rv2752c_p.Phe448Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4228 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Phe472fs Rv2752c_p.Phe472fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4297 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Phe497Cys Rv2752c_p.Phe497Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4412 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Phe49Leu Rv2752c_p.Phe49Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4379 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3623 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Pro101Ala Rv2752c_p.Pro101Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 9 0 9 0 20 9481 35685 0 0 0.00038900558066021 0.999439854362134 0.999135032404509 0.999657815983264 0 0 0.168433470983085 0 0 0.336267116879942 0 0 0.168433470983085 0 0 1.90727530746732 0.219226411707279 257 4975 False False 0 0 0.762572985704327 0 0 0.00038900558066021 0.999439854362134 0.999135032404509 0.999657815983264 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 0 19 6560 26486 0 0 0.000562171107654053 0.999283154121863 0.998880781714398 0.999568358524102 0 0 0.176466911806965 0 0 0.336267116879942 0 0 0.176466911806965 0 0 2.0461383766694 0.220117807515187 157 4087 False False 0 0 0 0 0 0 0 0 0 0.865443021143955 0 0 0.000562171107654053 0.999283154121863 0.998880781714398 0.999568358524102 5 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Pro101Leu Rv2752c_p.Pro101Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Pro10Arg Rv2752c_p.Pro10Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4426 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Pro123Ala Rv2752c_p.Pro123Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.096562813829025 Inf 0.209821626167397 198.5 4975 False False Inf 0.096562813829025 Inf 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.103599830448027 Inf 0.198397096627854 142 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Pro123Leu Rv2752c_p.Pro123Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 127 290 9354 35415 0.0133952114755827 0.0111788860496843 0.0159174498480078 0.991877888250945 0.990891754889701 0.992782701945012 0.304556354916067 0.26070921904926 0.3512029781284 NA NA NA 0 0 0.0126397132413124 NA NA NA NA 4191 4975 False True 1.65804229059299 1.33343870133946 2.05215426820883 0 0 0.000394286098927723 0.991877888250945 0.990891754889701 0.992782701945012 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 68 210 6492 26295 0.0103658536585365 0.00805822993223355 0.0131229250757214 0.992076966610073 0.990935030421553 0.993108945875886 0.244604316546762 0.195240316254557 0.299502958686881 NA NA NA 0 0 0.0174127082678636 NA NA NA NA 3468 4087 False True 0 1 1 0 0 0 0 1.31154827920077 0.981286300137533 1.73424991708008 0 0 0.000568057856809984 0.992076966610073 0.990935030421553 0.993108945875886 72 5) Not assoc w R New NotAwR yes 5 +Ethambutol Rv2752c p.Pro123Ser Rv2752c_p.Pro123Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4380 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3624 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Pro178Leu Rv2752c_p.Pro178Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Pro182Leu Rv2752c_p.Pro182Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4245 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Pro186Ser Rv2752c_p.Pro186Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Pro209Ala Rv2752c_p.Pro209Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Pro209Ser Rv2752c_p.Pro209Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Pro213Ala Rv2752c_p.Pro213Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Pro213fs Rv2752c_p.Pro213fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Pro213Leu Rv2752c_p.Pro213Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Pro220Ala Rv2752c_p.Pro220Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4192 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3469 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Pro220fs Rv2752c_p.Pro220fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 2 3 9479 35702 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.99991597815432 0.999754472342108 0.99998267234027 0.4 0.0527449505263169 0.853367200365326 0 0 0.975 0 0 0.707598226178713 0 0 146.560824366152 1 2818.5 4975 False False 2.51095403875232 0.209684820120099 21.9222407664312 0 0 0.000389087642036349 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 3 6558 26502 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999886813808715 0.999669257903365 0.999976657677988 0.4 0.0527449505263169 0.853367200365326 0 0 0.975 0 0 0.707598226178713 0 0 157.226876338096 1 1103 4087 False False 0 0 0 0 0 0 0 2.69411405916437 0.224966079471659 23.5225659748306 0 0 0.00056234250533983 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Pro220Leu Rv2752c_p.Pro220Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Pro390Arg Rv2752c_p.Pro390Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4289 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Pro390Leu Rv2752c_p.Pro390Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 53 54 9428 35651 0.00559012762366839 0.00419011038284122 0.00730572445059807 0.998487606777762 0.998027109815002 0.998863645742098 0.495327102803738 0.397240803090091 0.593678587075528 0 0 0.975 0 0 0.0660315142444217 0 0 147.141806925904 1 2818.5 4975 False False 3.71136999324313 2.49011837401591 5.52886789530406 0 0 0.00039119196829176 0.998487606777762 0.998027109815002 0.998863645742098 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 51 26 6509 26479 0.00777439024390243 0.00579386453192301 0.0102093652271214 0.999019053008866 0.998563013375042 0.999359115925842 0.662337662337662 0.545540637353491 0.766224038020354 0 0 0.841886116991581 0 0 0.132274604497754 0 0 21.6668481064453 1 2276.5 4087 False False 0 0 0 0 0 0 0 7.97965538839713 4.87864370866972 13.3418348125216 0 0 0.000566574641669827 0.999019053008866 0.998563013375042 0.999359115925842 12 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Pro395Ser Rv2752c_p.Pro395Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4369 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3615 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Pro416Leu Rv2752c_p.Pro416Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Pro443Leu Rv2752c_p.Pro443Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 7 9481 35698 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 3.1981371883326 0.354695326132256 279 4975 False False 0 0 2.61285174975179 0 0 0.00038900558066021 0.999803949026747 0.999596102051779 0.999921173824063 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.40943166615857 0.590385352956204 278 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Pro486Leu Rv2752c_p.Pro486Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4246 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Pro490Arg Rv2752c_p.Pro490Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4498 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3711 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Pro490fs Rv2752c_p.Pro490fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4478 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3696 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Pro50Leu Rv2752c_p.Pro50Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Pro549Gln Rv2752c_p.Pro549Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Pro549Leu Rv2752c_p.Pro549Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Pro549Ser Rv2752c_p.Pro549Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3526 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Pro553Leu Rv2752c_p.Pro553Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Pro553Ser Rv2752c_p.Pro553Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11552986995339 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Pro55Ser Rv2752c_p.Pro55Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Pro62Leu Rv2752c_p.Pro62Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4438 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Pro62Ser Rv2752c_p.Pro62Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Pro62Thr Rv2752c_p.Pro62Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4236 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3508 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Pro6Arg Rv2752c_p.Pro6Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Pro6fs Rv2752c_p.Pro6fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4390 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3633 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Pro7fs Rv2752c_p.Pro7fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 146.529978407112 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3523 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Pro7Gln Rv2752c_p.Pro7Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Pro8fs Rv2752c_p.Pro8fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0615661524565 1 2818.5 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Pro8Ser Rv2752c_p.Pro8Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4362 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Pro91Leu Rv2752c_p.Pro91Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 73 25 9408 35680 0.0076996097458074 0.00603998086623841 0.00967150023545393 0.999299817952667 0.998966565499085 0.999546829455204 0.744897959183673 0.646857472223162 0.827613689278087 NA NA NA 0 0 0.137185171530712 NA NA NA NA 4298 4975 False False 11.0741496598639 6.94179312459459 18.2129843191914 0 0 0.000392023420842937 0.999299817952667 0.998966565499085 0.999546829455204 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 59 25 6501 26480 0.00899390243902439 0.00685342482359412 0.011586333357009 0.999056781739294 0.998607936501749 0.999389508781733 0.702380952380952 0.592723646087301 0.797270818207111 NA NA NA 0 0 0.137185171530712 NA NA NA NA 3560 4087 False False 0 0 0 0 0 0 0 9.61279803107214 5.9229465400205 16.0296613872314 0 0 0.000567271659249183 0.999056781739294 0.998607936501749 0.999389508781733 5 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ser133fs Rv2752c_p.Ser133fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ser13Tyr Rv2752c_p.Ser13Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ser149Phe Rv2752c_p.Ser149Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 2 4 9479 35701 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999887970872426 0.999713186009257 0.999969475016731 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.841886116991581 0 0 0.602364635616474 0 0 20.0625561022088 1 2818.5 4975 False False 1.88316278088405 0.170308362439121 13.1422755166224 0 0 0.000389087642036349 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 157.21479794295 1 1103 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ser189* Rv2752c_p.Ser189* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ser240Cys Rv2752c_p.Ser240Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ser240fs Rv2752c_p.Ser240fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4479 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ser240Phe Rv2752c_p.Ser240Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 4.10971321225031 0.590981128432313 516.5 4975 False False 0 0 3.19822685561766 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.40943166615857 0.590385352956204 278 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ser240Pro Rv2752c_p.Ser240Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4179 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3460 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ser260* Rv2752c_p.Ser260* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4299 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3561 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ser284Ala Rv2752c_p.Ser284Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ser284fs Rv2752c_p.Ser284fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ser284Pro Rv2752c_p.Ser284Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4290 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3553 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ser313Leu Rv2752c_p.Ser313Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 1 9479 35704 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999971992718106 0.999843963402622 0.999999290917266 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 4370 4975 False False 7.53328410169849 0.392120325718966 443.147628387906 0 0 0.000389087642036349 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3616 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ser313Trp Rv2752c_p.Ser313Trp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4351 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ser316Leu Rv2752c_p.Ser316Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4403 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3643 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ser319Leu Rv2752c_p.Ser319Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ser319Pro Rv2752c_p.Ser319Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0615661524565 1 2818.5 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.5214194708504 1 2276.5 4087 False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 0 0 0.000562256793434776 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ser337Leu Rv2752c_p.Ser337Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 20.058335224773 1 1480 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 157.179059039538 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ser337Pro Rv2752c_p.Ser337Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3599 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ser338Leu Rv2752c_p.Ser338Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4489 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ser338Pro Rv2752c_p.Ser338Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ser339del Rv2752c_p.Ser339del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 0 0 0 8 2 9473 35703 0.000843792848855605 0.000364358012393849 0.00166192766222289 0.999943985436213 0.999797670939776 0.99999321630447 0.8 0.443904537692358 0.974789273673166 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4194 4975 False False 15.0756887997466 3.00779033710386 145.661578325072 0 0 0.000389334034028122 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 8 1 6552 26504 0.00121951219512195 0.000526641184096925 0.00240150352406598 0.999962271269571 0.999789807096406 0.999999044791703 0.888888888888888 0.517503485082663 0.9971908632534 NA NA NA 0 0 0.975 NA NA NA NA 3471 4087 False False 0 0 0 0 0 0 0 32.3614163614163 4.33671337572761 1425.06187007021 0 0 0.000562857326050777 0.999962271269571 0.999789807096406 0.999999044791703 2 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ser339Pro Rv2752c_p.Ser339Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4193 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3470 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ser339* Rv2752c_p.Ser339* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4381 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3625 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ser356Cys Rv2752c_p.Ser356Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 1 9479 35704 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999971992718106 0.999843963402622 0.999999290917266 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 4260 4975 False False 7.53328410169849 0.392120325718966 443.147628387906 0 0 0.000389087642036349 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 1 6558 26504 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999962271269571 0.999789807096406 0.999999044791703 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 3527 4087 False False 0 0 0 0 0 0 0 8.08295211954864 0.420719628662148 475.373667785977 0 0 0.00056234250533983 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ser356Pro Rv2752c_p.Ser356Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 5 4 9476 35701 0.000527370530534753 0.000171257241502832 0.00123027414547083 0.999887970872426 0.999713186009257 0.999969475016731 0.555555555555555 0.212008506778868 0.863004337734833 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4272 4975 False False 4.70939742507387 1.01338649657011 23.7370889289433 0 0 0.000389210799037296 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 5 4 6555 26501 0.000762195121951219 0.000247527523788107 0.00177780526826415 0.999849085078287 0.999613643356053 0.999958879281354 0.555555555555555 0.212008506778868 0.863004337734833 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3537 4087 False False 0 0 0 0 0 0 0 5.05358504958047 1.08735642260634 25.4630909640805 0 0 0.00056259979792051 0.999849085078287 0.999613643356053 0.999958879281354 3 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ser373Phe Rv2752c_p.Ser373Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4247 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3517 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ser373Tyr Rv2752c_p.Ser373Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4300 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3562 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ser412Arg Rv2752c_p.Ser412Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ser419* Rv2752c_p.Ser419* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4352 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ser428Gly Rv2752c_p.Ser428Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ser437Gly Rv2752c_p.Ser437Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12104088004766 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ser439Cys Rv2752c_p.Ser439Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4314 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3574 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ser439Phe Rv2752c_p.Ser439Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 2 5 9479 35700 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999859963590533 0.999673232250017 0.999954529045718 0.285714285714285 0.0366925661760855 0.709579136262657 0 0 0.707598226178713 0 0 0.521823750104981 0 0 9.11694228265779 1 2818.5 4975 False False 1.50648802616309 0.143410178089837 9.20379905242336 0 0 0.000389087642036349 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 2 6558 26503 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999924542539143 0.999727448570663 0.999990861620785 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 157.232794181633 1 2276.5 4087 False False 0 0 0 0 0 0 0 4.04132357426044 0.292866339798886 55.7129032982466 0 0 0.00056234250533983 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ser439Pro Rv2752c_p.Ser439Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4280 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3546 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ser470Leu Rv2752c_p.Ser470Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4301 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3563 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 2 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ser470Pro Rv2752c_p.Ser470Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4439 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3669 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ser494Leu Rv2752c_p.Ser494Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4371 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3617 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ser494Pro Rv2752c_p.Ser494Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4255 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3524 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ser498Ala Rv2752c_p.Ser498Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4353 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3600 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ser498fs Rv2752c_p.Ser498fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ser498Pro Rv2752c_p.Ser498Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 21 6 9460 35699 0.00221495622824596 0.00137159943312054 0.00338381350894567 0.99983195630864 0.999634275787128 0.999938328510354 0.777777777777777 0.577416939955621 0.913783060052433 0 0 0.975 0 0 0.4592581264399 0 0 146.842198622583 1 2818.5 4975 False False 13.2078752642706 5.15395597987394 39.9999999987508 0 0 0.000389868955347791 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 5 4 6555 26501 0.000762195121951219 0.000247527523788107 0.00177780526826415 0.999849085078287 0.999613643356053 0.999958879281354 0.555555555555555 0.212008506778868 0.863004337734833 0 0 0.975 0 0 0.602364635616474 0 0 157.292736322615 1 2276.5 4087 False False 0 0 0 0 0 0 0 5.05358504958047 1.08735642260634 25.4630909640805 0 0 0.00056259979792051 0.999849085078287 0.999613643356053 0.999958879281354 12 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ter559ext*? Rv2752c_p.Ter559ext*? 2 stop_lost (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ter559Glnext*? Rv2752c_p.Ter559Glnext*? 2 stop_lost (see "Genomic_coordinates" sheet) 1 0 0 0 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4440 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3670 4087 False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 0 0 0.000562256793434776 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Ter559Tyrext*? Rv2752c_p.Ter559Tyrext*? 2 stop_lost (see "Genomic_coordinates" sheet) 1 0 0 0 6 3 9475 35702 0.000632844636641704 0.000232277107744303 0.00137692358870305 0.99991597815432 0.999754472342108 0.99998267234027 0.666666666666666 0.29929505620854 0.925145368580308 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4208 4975 False False 7.53604221635883 1.60899726455665 46.5481525523134 0 0 0.000389251868698371 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 6 2 6554 26503 0.000914634146341463 0.000335726224038477 0.00198970246660848 0.999924542539143 0.999727448570663 0.999990861620785 0.75 0.349144205587175 0.968145973750055 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3487 4087 False False 0 0 0 0 0 0 0 12.1313701556301 2.1683237669748 123.038341532173 0 0 0.000562685614442453 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Thr122Ile Rv2752c_p.Thr122Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 3.76624472573839 0.0479745002090283 294.932792118969 0.375621806809355 335.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 4.04085988717792 0.0514701624188962 316.380494544091 0.35743759524028 195 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Thr12Ala Rv2752c_p.Thr12Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Thr134Ser Rv2752c_p.Thr134Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Thr150Pro Rv2752c_p.Thr150Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Thr160Asn Rv2752c_p.Thr160Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4302 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3564 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Thr160Ile Rv2752c_p.Thr160Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Thr160Pro Rv2752c_p.Thr160Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Thr164fs Rv2752c_p.Thr164fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4281 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3547 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Thr183Ile Rv2752c_p.Thr183Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4441 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3671 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Thr183Pro Rv2752c_p.Thr183Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4449 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3677 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Thr204Ala Rv2752c_p.Thr204Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Thr204Arg Rv2752c_p.Thr204Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4427 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3659 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Thr221Ala Rv2752c_p.Thr221Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4464 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3686 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Thr305Asn Rv2752c_p.Thr305Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Thr307Ala Rv2752c_p.Thr307Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Thr307Pro Rv2752c_p.Thr307Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4169 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3452 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Thr329Ala Rv2752c_p.Thr329Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4195 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3472 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Thr329Pro Rv2752c_p.Thr329Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 2 8 9479 35697 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999775941744853 0.999558563909973 0.999903262744512 0.2 0.0252107263268333 0.556095462307641 0 0 0.409616397225003 0 0 0.369416647552819 0 0 2.61332988355679 0.357635898426087 305 4975 False False 0.941475894081654 0.0973783182815292 4.71874266187613 0 0 0.000389087642036349 0.999775941744853 0.999558563909973 0.999903262744512 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 2 5 6558 26500 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999811356347858 0.999559824020536 0.9999387451734 0.285714285714285 0.0366925661760855 0.709579136262657 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.41077668756776 0.590386361627705 297 4087 False False 0 0 0 0 0 0 0 1.61634644708752 0.15386320830351 9.87586276350829 0 0 0.00056234250533983 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Thr32Arg Rv2752c_p.Thr32Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4180 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Thr364Ile Rv2752c_p.Thr364Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 3 9480 35702 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99991597815432 0.999754472342108 0.99998267234027 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4372 4975 False False 1.25534458509142 0.0239099774609589 15.6346568618898 0 0 0.00038904660702099 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Thr364Pro Rv2752c_p.Thr364Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 146.529978407112 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3650 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Thr399Ile Rv2752c_p.Thr399Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4428 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Thr413Ile Rv2752c_p.Thr413Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4282 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3548 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Thr461Ile Rv2752c_p.Thr461Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 2 4 9479 35701 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999887970872426 0.999713186009257 0.999969475016731 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.841886116991581 0 0 0.602364635616474 0 0 20.0625561022088 1 2818.5 4975 False False 1.88316278088405 0.170308362439121 13.1422755166224 0 0 0.000389087642036349 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 3 6558 26502 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999886813808715 0.999669257903365 0.999976657677988 0.4 0.0527449505263169 0.853367200365326 0 0 0.975 0 0 0.707598226178713 0 0 157.226876338096 1 1103 4087 False False 0 0 0 0 0 0 0 2.69411405916437 0.224966079471659 23.5225659748306 0 0 0.00056234250533983 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Thr461Pro Rv2752c_p.Thr461Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4256 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Thr461Ser Rv2752c_p.Thr461Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Thr476fs Rv2752c_p.Thr476fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4413 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Thr476Pro Rv2752c_p.Thr476Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 157.21479794295 1 1103 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Thr536Met Rv2752c_p.Thr536Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Thr536Ser Rv2752c_p.Thr536Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 9.1150193618684 1 2818.5 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 21.5173342675905 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Thr544fs Rv2752c_p.Thr544fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 9479 35704 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999971992718106 0.999843963402622 0.999999290917266 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 146.569015564619 1 2818.5 4975 False False 7.53328410169849 0.392120325718966 443.147628387906 0 0 0.000389087642036349 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 6558 26504 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999962271269571 0.999789807096406 0.999999044791703 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 157.238712024072 1 1103 4087 False False 0 0 0 0 0 0 0 8.08295211954864 0.420719628662148 475.373667785977 0 0 0.00056234250533983 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Thr554Pro Rv2752c_p.Thr554Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4283 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Thr80Ala Rv2752c_p.Thr80Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 4 9479 35701 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999887970872426 0.999713186009257 0.999969475016731 0.333333333333333 0.0432718682927417 0.777221904496487 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4480 4975 False False 1.88316278088405 0.170308362439121 13.1422755166224 0 0 0.000389087642036349 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3697 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Thr80Ile Rv2752c_p.Thr80Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 12 0 12 0 12 9481 35693 0 0 0.00038900558066021 0.99966391261728 0.999412996653316 0.999826327071809 0 0 0.264648469397051 0 0 0.264648469397051 0 0 0.264648469397051 0 0 1.35519147325258 0.0835905265175333 111 4975 False False 0 0 1.35519147325258 0 0 0.00038900558066021 0.99966391261728 0.999412996653316 0.999826327071809 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 12 0 12 0 12 6560 26493 0 0 0.000562171107654053 0.999547255234861 0.999209279704825 0.999766038988972 0 0 0.264648469397051 0 0 0.264648469397051 0 0 0.264648469397051 0 0 1.45386850159099 0.140764243939364 113 4087 False False 0 0 0 0 0 0 0 0 0 1.45386850159099 0 0 0.000562171107654053 0.999547255234861 0.999209279704825 0.999766038988972 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Trp400Arg Rv2752c_p.Trp400Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Trp400* Rv2752c_p.Trp400* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 14 4 9467 35701 0.00147663748549731 0.000807519189222099 0.00247630687876465 0.999887970872426 0.999713186009257 0.999969475016731 0.777777777777777 0.52362723426352 0.935907952282333 0 0 0.975 0 0 0.602364635616474 0 0 146.742072419141 1 2818.5 4975 False False 13.1988486320904 4.14362023846238 55.102479950484 0 0 0.000389580738275926 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 10 2 6550 26503 0.00152439024390243 0.000731238785140689 0.00280161526425175 0.999924542539143 0.999727448570663 0.999990861620785 0.833333333333333 0.515862251314033 0.979137474539907 0 0 0.975 0 0 0.841886116991581 0 0 157.424361863986 1 2276.5 4087 False False 0 0 0 0 0 0 0 20.2312977099236 4.3094890893401 189.535571223342 0 0 0.000563029142491623 0.999924542539143 0.999727448570663 0.999990861620785 9 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Trp540Arg Rv2752c_p.Trp540Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 9478 35705 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 1 0.999896689850119 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4261 4975 False False Inf 1.55639137151076 Inf 0 0 0.000389128685709026 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 6557 26505 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 1 0.999860832946126 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3528 4087 False False 0 0 0 0 0 0 0 Inf 1.66990152933523 Inf 0 0 0.000562428243381166 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Trp540fs Rv2752c_p.Trp540fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4248 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Trp540Gly Rv2752c_p.Trp540Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4450 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3678 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Trp540* Rv2752c_p.Trp540* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 1 0 3 0 9478 35705 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 1 0.999896689850119 1 1 0.292401773821286 1 1 0.025 1 1 0.025 1 Inf 0.0965831879183891 Inf 0.209786650141643 171.5 4975 False False Inf 1.55639137151076 Inf 0.000105496360375567 2.67093302808208e-06 0.000587646375974446 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Tyr143Cys Rv2752c_p.Tyr143Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4442 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3672 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Tyr143* Rv2752c_p.Tyr143* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4347 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Tyr159fs Rv2752c_p.Tyr159fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4451 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3679 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Tyr159* Rv2752c_p.Tyr159* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Tyr377Asp Rv2752c_p.Tyr377Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Tyr385Asp Rv2752c_p.Tyr385Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 1 9478 35704 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999971992718106 0.999843963402622 0.999999290917266 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 146.584444274952 1 1480 4975 False False 11.3011183794049 0.90722384791697 591.183089908516 0 0 0.000389128685709026 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Tyr545Cys Rv2752c_p.Tyr545Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val102Ala Rv2752c_p.Val102Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 9480 35702 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99991597815432 0.999754472342108 0.99998267234027 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.11649128277037 1 2818.5 4975 False False 1.25534458509142 0.0239099774609589 15.6346568618898 0 0 0.00038904660702099 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 3 6559 26502 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999886813808715 0.999669257903365 0.999976657677988 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.78133043653875 1 2276.5 4087 False False 0 0 0 0 0 0 0 1.34685165421558 0.025651688752077 16.7753654027497 0 0 0.000562256793434776 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val102Ile Rv2752c_p.Val102Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val103Asp Rv2752c_p.Val103Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4170 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3453 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val112_Ala113del Rv2752c_p.Val112_Ala113del 2 inframe_deletion (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4323 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3578 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val112Ile Rv2752c_p.Val112Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val124Met Rv2752c_p.Val124Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val128Gly Rv2752c_p.Val128Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4237 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3509 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val138Ala Rv2752c_p.Val138Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4490 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val138Leu Rv2752c_p.Val138Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 146.529978407112 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 157.179059039538 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val146dup Rv2752c_p.Val146dup 2 inframe_insertion (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4209 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val146fs Rv2752c_p.Val146fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 16 0 9465 35705 0.00168758569771121 0.00096489905765009 0.00273909056442828 1 0.999896689850119 1 1 0.794092785792177 1 NA NA NA NA NA NA NA NA NA NA 4354 4975 False False Inf 14.5403806655928 Inf 0 0 0.000389663042518041 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 5 0 6555 26505 0.000762195121951219 0.000247527523788107 0.00177780526826415 1 0.999860832946126 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 3601 4087 False False 0 0 0 0 0 0 0 Inf 3.70403509656001 Inf 0 0 0.00056259979792051 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val146Leu Rv2752c_p.Val146Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 4.10971321225031 0.590981128432313 516.5 4975 False False 0 0 3.19822685561766 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 6 6560 26499 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 4.40926527811573 0.590385229079199 260 4087 False False 0 0 0 0 0 0 0 0 0 3.43165838346939 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val196Ala Rv2752c_p.Val196Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12104088004766 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val211Ala Rv2752c_p.Val211Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val211Ile Rv2752c_p.Val211Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4196 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3473 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val211Leu Rv2752c_p.Val211Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val218Leu Rv2752c_p.Val218Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 9 0 9 0 12 9481 35693 0 0 0.00038900558066021 0.99966391261728 0.999412996653316 0.999826327071809 0 0 0.264648469397051 0 0 0.336267116879942 0 0 0.264648469397051 0 0 1.90770287770578 0.21922392121523 254.5 4975 False False 0 0 1.35519147325258 0 0 0.00038900558066021 0.99966391261728 0.999412996653316 0.999826327071809 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 8 6560 26497 0 0 0.000562171107654053 0.999698170156574 0.999405361976814 0.999869682578628 0 0 0.369416647552819 0 0 0.4592581264399 0 0 0.369416647552819 0 0 3.43139939855491 0.605987594467308 325 4087 False False 0 0 0 0 0 0 0 0 0 2.36695385477914 0 0 0.000562171107654053 0.999698170156574 0.999405361976814 0.999869682578628 4 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val233Gly Rv2752c_p.Val233Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4181 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3461 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val233Met Rv2752c_p.Val233Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val242Met Rv2752c_p.Val242Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val245Ile Rv2752c_p.Val245Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 0 0 0.602364635616474 0 0 0.4592581264399 0 0 5.70483372250837 0.585894740941386 369 4975 False False 0 0 3.19822685561766 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 157.179059039538 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val245Leu Rv2752c_p.Val245Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4262 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3529 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val272Ala Rv2752c_p.Val272Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 15 0 15 1 18 9480 35687 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99949586892592 0.999203372130377 0.999701193476901 0.0526315789473684 0.00133162880417942 0.260280654195214 0 0 0.218019360910534 0 0 0.185301968137852 0 0 1.04978751615897 0.0524891445858366 100 4975 False False 0.20913619315518 0.00502263873391001 1.32494056057363 0 0 0.00038904660702099 0.99949586892592 0.999203372130377 0.999701193476901 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 0 11 0 13 6560 26492 0 0 0.000562171107654053 0.999509526504433 0.999161421428146 0.999738818498366 0 0 0.24705263800047 0 0 0.284914152918154 0 0 0.24705263800047 0 0 1.60953536718399 0.136615545675825 101 4087 False False 0 0 0 0 0 0 0 0 0 1.32548813951656 0 0 0.000562171107654053 0.999509526504433 0.999161421428146 0.999738818498366 2 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val281Glu Rv2752c_p.Val281Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val300Ala Rv2752c_p.Val300Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 70 134 9411 35571 0.00738318742748655 0.00575994783896182 0.00931913103838666 0.996247024226298 0.995556654512836 0.996854617618715 0.34313725490196 0.278252505722555 0.412657001843974 NA NA NA 0 0 0.0271534828798001 NA NA NA NA 4291 4975 False True 1.97448365440886 1.45585822929321 2.65806367582793 0 0 0.000391898477714434 0.996247024226298 0.995556654512836 0.996854617618715 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 63 114 6497 26391 0.00960365853658536 0.00738738280845259 0.0122707406594272 0.995698924731182 0.994835333276786 0.996450872353136 0.35593220338983 0.285531839118816 0.431247776388369 NA NA NA 0 0 0.0318406540834741 NA NA NA NA 3554 4087 False True 0 1 1 0 0 0 0 2.24480529475142 1.62125770878223 3.08409487760427 0 0 0.000567620811554055 0.995698924731182 0.994835333276786 0.996450872353136 11 5) Not assoc w R New NotAwR yes 5 +Ethambutol Rv2752c p.Val335Met Rv2752c_p.Val335Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.10982832991351 0.590980565810755 492 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val348fs Rv2752c_p.Val348fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 66 4 9415 35701 0.00696129100305874 0.00538783345090772 0.00884806789608294 0.999887970872426 0.999713186009257 0.999969475016731 0.942857142857142 0.860105825902021 0.984212917846756 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4197 4975 False False 62.5668082846521 23.3014984993466 235.216793309624 0 0 0.000391732010711525 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 66 4 6494 26501 0.010060975609756 0.0077894620355648 0.0127824712386754 0.999849085078287 0.999613643356053 0.999958879281354 0.942857142857142 0.860105825902021 0.984212917846756 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3474 4087 False False 0 0 0 0 0 0 0 67.3339236218047 25.0818490151581 254.363629295161 0 0 0.000567882957970726 0.999849085078287 0.999613643356053 0.999958879281354 2 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val351Ala Rv2752c_p.Val351Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 16 9481 35689 0 0 0.00038900558066021 0.999551883489707 0.999272388596077 0.99974384169233 0 0 0.205907214207822 0 0 0.409616397225003 0 0 0.205907214207822 0 0 2.61219308791253 0.357642996231103 322 4975 False False 0 0 0.976295497466411 0 0 0.00038900558066021 0.999551883489707 0.999272388596077 0.99974384169233 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 11 6560 26494 0 0 0.000562171107654053 0.999584983965289 0.999257543293353 0.999792807866341 0 0 0.284914152918154 0 0 0.409616397225003 0 0 0.284914152918154 0 0 2.80285295271672 0.357901917154265 204 4087 False False 0 0 0 0 0 0 0 0 0 1.60965686204705 0 0 0.000562171107654053 0.999584983965289 0.999257543293353 0.999792807866341 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val370Gly Rv2752c_p.Val370Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 157.21479794295 1 1103 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val372fs Rv2752c_p.Val372fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 9477 35705 0.000421896424427802 0.000114964157806894 0.00107986688593449 1 0.999896689850119 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 4334 4975 False False Inf 2.4863933079676 Inf 0 0 0.000389169738041761 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 6556 26505 0.000609756097560975 0.000166162208307701 0.00156047520083291 1 0.999860832946126 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3586 4087 False False 0 0 0 0 0 0 0 Inf 2.66797681781562 Inf 0 0 0.000562514007570737 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val388fs Rv2752c_p.Val388fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4303 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val388Glu Rv2752c_p.Val388Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4238 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3510 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val393Leu Rv2752c_p.Val393Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4414 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3651 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val393Met Rv2752c_p.Val393Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4391 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3634 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val396Gly Rv2752c_p.Val396Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val415Ala Rv2752c_p.Val415Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val415Gly Rv2752c_p.Val415Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 157.21479794295 1 1103 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val415Ile Rv2752c_p.Val415Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4273 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3538 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val429Phe Rv2752c_p.Val429Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val432fs Rv2752c_p.Val432fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4257 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val457Ile Rv2752c_p.Val457Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val473Ala Rv2752c_p.Val473Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4499 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3712 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val473Gly Rv2752c_p.Val473Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val475Ala Rv2752c_p.Val475Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val477Ile Rv2752c_p.Val477Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4239 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3511 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val47Ala Rv2752c_p.Val47Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val47fs Rv2752c_p.Val47fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4215 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3491 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val47Met Rv2752c_p.Val47Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val511fs Rv2752c_p.Val511fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val511Gly Rv2752c_p.Val511Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0615661524565 1 2818.5 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val523Phe Rv2752c_p.Val523Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4304 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3565 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val533Ala Rv2752c_p.Val533Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.10982832991351 0.590980565810755 492 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.40943166615857 0.590385352956204 278 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val533fs Rv2752c_p.Val533fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val533Gly Rv2752c_p.Val533Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 2 9479 35703 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999943985436213 0.999797670939776 0.99999321630447 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 146.564919965648 1 1480 4975 False False 3.76653655448887 0.272970929153834 51.9466713138689 0 0 0.000389087642036349 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 6558 26504 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999962271269571 0.999789807096406 0.999999044791703 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 157.238712024072 1 1103 4087 False False 0 0 0 0 0 0 0 8.08295211954864 0.420719628662148 475.373667785977 0 0 0.00056234250533983 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val537Phe Rv2752c_p.Val537Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val541Gly Rv2752c_p.Val541Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val552Ala Rv2752c_p.Val552Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val552Gly Rv2752c_p.Val552Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 157.21479794295 1 1103 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val555Ala Rv2752c_p.Val555Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val555Gly Rv2752c_p.Val555Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4500 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3713 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val555Ile Rv2752c_p.Val555Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val558fs Rv2752c_p.Val558fs 2 frameshift (see "Genomic_coordinates" sheet) 1 10 0 10 0 10 9481 35695 0 0 0.00038900558066021 0.999719927181067 0.999484996631079 0.999865686288203 0 0 0.30849710781876 0 0 0.30849710781876 0 0 0.30849710781876 0 0 1.67996531074212 0.134582133412278 140.5 4975 False False 0 0 1.67996531074212 0 0 0.00038900558066021 0.999719927181067 0.999484996631079 0.999865686288203 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 6560 26499 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.43165838346939 0.605981932438924 311.5 4087 False False 0 0 0 0 0 0 0 0 0 3.43165838346939 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val558Gly Rv2752c_p.Val558Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 9.1150193618684 1 2818.5 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val57Gly Rv2752c_p.Val57Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4501 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3714 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val67Gly Rv2752c_p.Val67Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 2 9479 35703 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999943985436213 0.999797670939776 0.99999321630447 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4452 4975 False False 3.76653655448887 0.272970929153834 51.9466713138689 0 0 0.000389087642036349 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 2 6558 26503 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999924542539143 0.999727448570663 0.999990861620785 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3680 4087 False False 0 0 0 0 0 0 0 4.04132357426044 0.292866339798886 55.7129032982466 0 0 0.00056234250533983 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol Rv2752c p.Val67Ile Rv2752c_p.Val67Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA c.105G>A ubiA_c.105G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 9 9481 35696 0 0 0.00038900558066021 0.99974793446296 0.999521555266748 0.999884733314884 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.90786321657339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 6 6560 26499 0 0 0.000562171107654053 0.99977362761743 0.99950734823901 0.999916920939814 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.43165838346939 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.105G>T ubiA_c.105G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.111G>A ubiA_c.111G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.126C>A ubiA_c.126C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.12T>C ubiA_c.12T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.132C>T ubiA_c.132C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.138C>T ubiA_c.138C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 27 9481 35678 0 0 0.00038900558066021 0.999243803388881 0.998899962900125 0.999501604380895 0 0 0.127702867615432 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.551051070388324 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 26 6560 26479 0 0 0.000562171107654053 0.999019053008866 0.998563013375042 0.999359115925842 0 0 0.132274604497754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.61549886584066 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.141C>T ubiA_c.141C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 14 9481 35691 0 0 0.00038900558066021 0.999607898053494 0.999342206985133 0.999785618166341 0 0 0.231635761650116 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.13511057396106 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 13 6560 26492 0 0 0.000562171107654053 0.999509526504433 0.999161421428146 0.999738818498366 0 0 0.24705263800047 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.32548813951656 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.144C>T ubiA_c.144C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.-14A>C ubiA_c.-14A>C 1 upstream_gene_variant 4269847 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA c.-14A>G ubiA_c.-14A>G 1 upstream_gene_variant 4269847 1 3 0 3 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.11527461591697 1 2818.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.77947080093164 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 12 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA c.159C>T ubiA_c.159C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.-15A>G ubiA_c.-15A>G 1 upstream_gene_variant 4269848 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA c.165G>A ubiA_c.165G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.186C>T ubiA_c.186C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.-18C>T ubiA_c.-18C>T 1 upstream_gene_variant 4269851 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4137 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3425 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA c.192G>A ubiA_c.192G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.1A>G ubiA_c.1A>G 1 initiator_codon_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.204G>A ubiA_c.204G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 11 9481 35694 0 0 0.00038900558066021 0.999691919899173 0.999448826618347 0.999846197812 0 0 0.284914152918154 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.50034693324555 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 11 6560 26494 0 0 0.000562171107654053 0.999584983965289 0.999257543293353 0.999792807866341 0 0 0.284914152918154 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.60965686204705 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.207G>A ubiA_c.207G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.707313928675496 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.210C>T ubiA_c.210C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.213C>T ubiA_c.213C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.219C>T ubiA_c.219C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 6 5 9475 35700 0.000632844636641704 0.000232277107744303 0.00137692358870305 0.999859963590533 0.999673232250017 0.999954529045718 0.545454545454545 0.233793597659345 0.832511905936292 NA NA NA NA NA NA NA NA NA NA NA NA False False 4.52137203166226 1.14932964148879 18.74197899831 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 6 5 6554 26500 0.000914634146341463 0.000335726224038477 0.00198970246660848 0.999811356347858 0.999559824020536 0.9999387451734 0.545454545454545 0.233793597659345 0.832511905936292 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.85199877937137 1.23324406616883 20.1025168964506 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.225G>A ubiA_c.225G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.228T>C ubiA_c.228T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 332 4054 9149 31651 0.0350174032275076 0.0314079442461584 0.0389160388459327 0.886458479204593 0.883122283382097 0.889731670594785 0.0756953944368445 0.0680378274578863 0.0839235010587456 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.283314072999532 0.251977928406271 0.317733905049689 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 249 3418 6311 23087 0.0379573170731707 0.0334632906004842 0.0428677967216801 0.87104319939634 0.866948795802167 0.875056071137148 0.067902917916553 0.0599708496216452 0.0765318188083268 NA NA NA NA NA NA NA NA NA NA NA NA False True 1 1 1 0 0 0 1 0.266499630661502 0.232693153693811 0.304163353116802 NA NA NA NA NA NA 675 5) Not assoc w R Now listed Silent mutation no 0 +Ethambutol ubiA c.231C>T ubiA_c.231C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.244C>A ubiA_c.244C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.246G>A ubiA_c.246G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.249G>A ubiA_c.249G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.252C>T ubiA_c.252C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.258C>T ubiA_c.258C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.76624472573839 0.0479745002090283 294.932792118969 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.-26A>G ubiA_c.-26A>G 1 upstream_gene_variant 4269859 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA c.282C>G ubiA_c.282C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.288G>A ubiA_c.288G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.294C>T ubiA_c.294C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 8 171 9473 35534 0.000843792848855605 0.000364358012393849 0.00166192766222289 0.995210754796247 0.994438835021646 0.995900333077031 0.0446927374301676 0.0194898454290933 0.0861607853092731 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.175489217431135 0.0745446744541847 0.353869850088548 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 8 171 6552 26334 0.00121951219512195 0.000526641184096925 0.00240150352406598 0.993548387096774 0.992509539606474 0.994476683623523 0.0446927374301676 0.0194898454290933 0.0861607853092731 NA NA NA NA NA NA NA NA NA NA NA NA False True 1 1 1 0 0 0 0 0.188034188034188 0.0798539974583729 0.379252258432693 NA NA NA NA NA NA 16 5) Not assoc w R Now listed Silent mutation no 0 +Ethambutol ubiA c.-2G>A ubiA_c.-2G>A 1 upstream_gene_variant 4269835 1 1 1 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.096562813829025 Inf 0.209821626167397 198.5 4975 False False Inf 0.096562813829025 Inf 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.103599830448027 Inf 0.198397096627854 142 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA c.301C>T ubiA_c.301C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.303G>A ubiA_c.303G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.312C>G ubiA_c.312C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.19822685561766 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.312C>T ubiA_c.312C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 60 9480 35645 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.998319563086402 0.997837466682431 0.998717412184314 0.0163934426229508 0.00041495991283974 0.0879881229227452 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.0626670182841069 0.00156483086762731 0.362854153647463 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 1 53 6559 26452 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.998000377287304 0.997385249983166 0.998501797605913 0.0185185185185185 0.00046873840381796 0.0989151595078512 NA NA NA NA NA NA NA NA NA NA NA NA False True 1 1 1 0 0 0 0 0.0760930537616468 0.00189499501133568 0.442877194491388 NA NA NA NA NA NA 1 5) Not assoc w R Now listed Silent mutation no 0 +Ethambutol ubiA c.-31C>T ubiA_c.-31C>T 1 upstream_gene_variant 4269864 1 25 1 24 1 37 9480 35668 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.998963730569948 0.998571919150772 0.999270269002357 0.0263157894736842 0.000666036204202366 0.13809902979242 0.04 0.00101219969931084 0.203516913922414 0.0263157894736842 0.000666036204202366 0.13809902979242 0.156768635724331 0.00381554520088018 0.9616409506689 0.0450456959636802 92 4975 False False 0.10168776371308 0.00251123916986922 0.603002326645461 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.998963730569948 0.998571919150772 0.999270269002357 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 20 0 20 0 31 6560 26474 0 0 0.000562171107654053 0.998830409356725 0.99834026667881 0.999205185871022 0 0 0.11218874692237 0 0 0.168433470983085 0 0 0.11218874692237 0 0 0.817703497064385 0.0214240273217057 52 4087 False False 0 0 0 0 0 0 0 0 0 0.510151817626531 0 0 0.000562171107654053 0.998830409356725 0.99834026667881 0.999205185871022 4 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA c.324A>C ubiA_c.324A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.324A>G ubiA_c.324A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.325C>T ubiA_c.325C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.-32delG ubiA_c.-32delG 1 upstream_gene_variant 4269864 0 0 0 0 12 749 9469 34956 0.0012656892732834 0.000654165731961641 0.0022098595784263 0.979022545861924 0.977482509665022 0.980483958664121 0.0157687253613666 0.00817378500681952 0.0273826479388537 NA NA NA 0 0 0.0049129644180757 NA NA NA NA 4084 4975 False True 0.0591448646775275 0.0303993129786972 0.103995931717195 0 0 0.00038949846879491 0.979022545861924 0.977482509665022 0.980483958664121 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 8 713 6552 25792 0.00121951219512195 0.000526641184096925 0.00240150352406598 0.973099415204678 0.971080117969625 0.975014073778819 0.0110957004160887 0.00480216988193693 0.021745374407148 NA NA NA 0 0 0.0051603832132064 NA NA NA NA 3381 4087 False True 1 1 1 0 0 0 0 0.0441683919944789 0.0189874980573659 0.0875974301425459 0 0 0.000562857326050777 0.973099415204678 0.971080117969625 0.975014073778819 37 5) Not assoc w R New NotAwR yes 5 +Ethambutol ubiA c.345C>T ubiA_c.345C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.351C>G ubiA_c.351C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.70515331951781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.12104088004766 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.358C>T ubiA_c.358C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.-35G>C ubiA_c.-35G>C 1 upstream_gene_variant 4269868 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA c.360G>C ubiA_c.360G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.363C>T ubiA_c.363C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.-37C>G ubiA_c.-37C>G 1 upstream_gene_variant 4269870 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA c.387C>T ubiA_c.387C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.390C>T ubiA_c.390C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.396C>T ubiA_c.396C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.39G>A ubiA_c.39G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.408G>A ubiA_c.408G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.417C>T ubiA_c.417C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.423T>C ubiA_c.423T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.-42G>A ubiA_c.-42G>A 1 upstream_gene_variant 4269875 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA c.-43C>T ubiA_c.-43C>T 1 upstream_gene_variant 4269876 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA c.459G>A ubiA_c.459G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 20 315 9461 35390 0.00210948212213901 0.00128898780543425 0.00325605306957067 0.991177706203612 0.990152728097484 0.992121543119283 0.0597014925373134 0.0368449470022701 0.0907005837111185 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.237499643482097 0.143015429059911 0.373368163111941 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 12 165 6548 26340 0.00182926829268292 0.000945555636841848 0.00319318105848117 0.993774759479343 0.992752797462048 0.99468607090169 0.0677966101694915 0.0355196121704141 0.115431853500057 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 1 0.292552896095962 0.14805023107403 0.525366100727608 NA NA NA NA NA NA 50 5) Not assoc w R Now listed Silent mutation no 0 +Ethambutol ubiA c.480C>A ubiA_c.480C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.480C>T ubiA_c.480C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.483C>T ubiA_c.483C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 8 343 9473 35362 0.000843792848855605 0.000364358012393849 0.00166192766222289 0.9903935023106 0.9893268520208 0.991379202820268 0.0227920227920227 0.00989015195499755 0.0444137940156539 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.0870653097540685 0.0372757973229272 0.17359026458385 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 7 316 6553 26189 0.0010670731707317 0.000429122972600259 0.00219733487653492 0.988077721184682 0.986697314394433 0.989349513744417 0.0216718266253869 0.00875655285427288 0.0441405688567051 NA NA NA NA NA NA NA NA NA NA NA NA False True 1 1 1 0 0 0 1 0.0885298452539855 0.0352867584802989 0.184701104215771 NA NA NA NA NA NA 30 5) Not assoc w R Now listed Silent mutation no 0 +Ethambutol ubiA c.489C>T ubiA_c.489C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.-48dupG ubiA_c.-48dupG 1 upstream_gene_variant 4269880 1 0 0 0 0 14 9481 35691 0 0 0.00038900558066021 0.999607898053494 0.999342206985133 0.999785618166341 0 0 0.231635761650116 NA NA NA 0 0 0.231635761650116 NA NA NA NA 4067 4975 False False 0 0 1.13511057396106 0 0 0.00038900558066021 0.999607898053494 0.999342206985133 0.999785618166341 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 14 6560 26491 0 0 0.000562171107654053 0.999471797774004 0.999113925067086 0.999711197799087 0 0 0.231635761650116 NA NA NA 0 0 0.231635761650116 NA NA NA NA 3364 4087 False False 0 0 0 0 0 0 0 0 0 1.21779664057642 0 0 0.000562171107654053 0.999471797774004 0.999113925067086 0.999711197799087 1 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA c.495C>T ubiA_c.495C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.76624472573839 0.0479745002090283 294.932792118969 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.504C>G ubiA_c.504C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.510C>T ubiA_c.510C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.513G>A ubiA_c.513G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.519C>G ubiA_c.519C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.10982832991351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.40943166615857 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.-51G>A ubiA_c.-51G>A 1 upstream_gene_variant 4269884 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4097 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3395 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA c.522G>A ubiA_c.522G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.534G>A ubiA_c.534G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.54C>T ubiA_c.54C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.564G>A ubiA_c.564G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.567C>T ubiA_c.567C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.582C>T ubiA_c.582C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 9 9481 35696 0 0 0.00038900558066021 0.99974793446296 0.999521555266748 0.999884733314884 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.90786321657339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 8 6560 26497 0 0 0.000562171107654053 0.999698170156574 0.999405361976814 0.999869682578628 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.36695385477914 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.606C>T ubiA_c.606C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.609C>T ubiA_c.609C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 1 9479 35704 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999971992718106 0.999843963402622 0.999999290917266 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 7.53328410169849 0.392120325718966 443.147628387906 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 2 1 6558 26504 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999962271269571 0.999789807096406 0.999999044791703 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 8.08295211954864 0.420719628662148 475.373667785977 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.612T>C ubiA_c.612T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.612T>G ubiA_c.612T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.642C>T ubiA_c.642C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 7 9480 35698 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999803949026747 0.999596102051779 0.999921173824063 0.125 0.0031597235312519 0.526509670875206 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.53794454490657 0.0119383062528594 4.18812953339448 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.40943166615857 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.654G>A ubiA_c.654G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.657G>A ubiA_c.657G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.663C>T ubiA_c.663C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 6 6 9475 35699 0.000632844636641704 0.000232277107744303 0.00137692358870305 0.99983195630864 0.999634275787128 0.999938328510354 0.5 0.210944638239296 0.789055361760703 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.76770448548812 1.00696556191593 14.0966097383566 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 6 6 6554 26499 0.000914634146341463 0.000335726224038477 0.00198970246660848 0.99977362761743 0.99950734823901 0.999916920939814 0.5 0.210944638239296 0.789055361760703 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.04317973756484 1.08042878256667 15.1287098658563 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.66C>G ubiA_c.66C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.672G>A ubiA_c.672G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.675G>A ubiA_c.675G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 3 2 9478 35703 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999943985436213 0.999797670939776 0.99999321630447 0.6 0.146632799634673 0.947255049473683 NA NA NA NA NA NA NA NA NA NA NA NA False False 5.65040092846592 0.647137685918782 67.7491623796885 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 3 2 6557 26503 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 0.999924542539143 0.999727448570663 0.999990861620785 0.6 0.146632799634673 0.947255049473683 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 6.06290986731737 0.694321240468692 72.4391518330217 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.681C>A ubiA_c.681C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.88306962025316 0.0319145727646777 36.1783621216076 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.687G>T ubiA_c.687G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.690C>G ubiA_c.690C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.699C>T ubiA_c.699C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.10982832991351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.-6G>T ubiA_c.-6G>T 1 upstream_gene_variant 4269839 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4116 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol ubiA c.702G>A ubiA_c.702G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.703C>T ubiA_c.703C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.729C>T ubiA_c.729C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.732C>T ubiA_c.732C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.11552986995339 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.735G>A ubiA_c.735G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.744C>T ubiA_c.744C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.75G>A ubiA_c.75G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.768C>G ubiA_c.768C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.10982832991351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.768C>T ubiA_c.768C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.771C>T ubiA_c.771C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.778C>T ubiA_c.778C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.783C>T ubiA_c.783C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 3 31 9478 35674 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999131774261308 0.998767847272761 0.999410008882762 0.088235294117647 0.0185795034408403 0.236775274286937 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.364245893716518 0.0712364468411853 1.16806860935258 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 29 6559 26476 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.998905866817581 0.998429017222443 0.999267123212173 0.0333333333333333 0.000843570926630479 0.172169455633412 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.139192791163497 0.00341127749854012 0.83986951332516 NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.789G>A ubiA_c.789G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.798C>A ubiA_c.798C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.798C>T ubiA_c.798C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.804C>T ubiA_c.804C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.807C>T ubiA_c.807C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.88306962025316 0.0319145727646777 36.1783621216076 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.810G>A ubiA_c.810G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 9 15 9472 35690 0.000949266954962556 0.000434154257137837 0.00180123610483098 0.9995798907716 0.999307188228015 0.999764849596654 0.375 0.187992928196002 0.594063615992055 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.26076858108108 0.872034995535318 5.51585126935066 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 6 8 6554 26497 0.000914634146341463 0.000335726224038477 0.00198970246660848 0.999698170156574 0.999405361976814 0.999869682578628 0.428571428571428 0.176611089982117 0.711390599961692 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.03215593530668 0.866809785310823 9.96915269753811 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.813C>A ubiA_c.813C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.819G>A ubiA_c.819G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.0594558180883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.518144632979 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.831C>T ubiA_c.831C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.834G>C ubiA_c.834G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.096562813829025 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.835C>T ubiA_c.835C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.846G>A ubiA_c.846G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.850T>C ubiA_c.850T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 6 9480 35699 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99983195630864 0.999634275787128 0.999938328510354 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.627619549929676 0.0136468000350686 5.17448319653473 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 3 6559 26502 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999886813808715 0.999669257903365 0.999976657677988 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.34685165421558 0.025651688752077 16.7753654027497 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.852G>A ubiA_c.852G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 8 9480 35697 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999775941744853 0.999558563909973 0.999903262744512 0.111111111111111 0.00280913674659921 0.482496514917337 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.47068829113924 0.010610026508271 3.51159115085171 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.77983968475814 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.858G>T ubiA_c.858G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.864G>A ubiA_c.864G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.865C>T ubiA_c.865C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.870G>A ubiA_c.870G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.891C>G ubiA_c.891C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.894T>G ubiA_c.894T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.-8G>A ubiA_c.-8G>A 1 upstream_gene_variant 4269841 1 12 0 12 2 12 9479 35693 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.99966391261728 0.999412996653316 0.999826327071809 0.142857142857142 0.0177945154831915 0.428129160909698 0 0 0.264648469397051 0 0 0.264648469397051 0 0 1.35547744744976 0.083602814422758 115 4975 False False 0.627580265147519 0.0682070896184037 2.81999711742652 0 0 0.000389087642036349 0.99966391261728 0.999412996653316 0.999826327071809 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 0 11 2 11 6558 26494 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999584983965289 0.999257543293353 0.999792807866341 0.153846153846153 0.0192066719825284 0.454471055676557 0 0 0.284914152918154 0 0 0.284914152918154 0 0 1.61014784671346 0.136631026047626 107 4087 False False 0 0 0 0 0 0 0 0.73453658266101 0.0790946916112532 3.36686446774636 0 0 0.00056234250533983 0.999584983965289 0.999257543293353 0.999792807866341 4 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA c.900C>T ubiA_c.900C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.76624472573839 0.0479745002090283 294.932792118969 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA c.906C>T ubiA_c.906C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 20 314 9461 35391 0.00210948212213901 0.00128898780543425 0.00325605306957067 0.991205713485506 0.990182258158074 0.992148020631093 0.059880239520958 0.0369564219758658 0.0909676109079312 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.238262744071033 0.143468080224206 0.374579139919462 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 12 163 6548 26342 0.00182926829268292 0.000945555636841848 0.00319318105848117 0.9938502169402 0.992833952515803 0.994755796956153 0.0685714285714285 0.035931352564915 0.116716476788669 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 1 0.296164988325944 0.149838377546212 0.532025381597384 NA NA NA NA NA NA 48 5) Not assoc w R Now listed Silent mutation no 0 +Ethambutol ubiA c.96G>A ubiA_c.96G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 146.538167885573 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 157.190891134799 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethambutol ubiA p.Ala115Thr ubiA_p.Ala115Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 6 9481 35699 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 0 0 0.4592581264399 0 0 0.707598226178713 0 0 0.4592581264399 0 0 9.11476410780766 1 1480 4975 False False 0 0 3.19822685561766 0 0 0.00038900558066021 0.99983195630864 0.999634275787128 0.999938328510354 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 157.173142990263 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Ala115Val ubiA_p.Ala115Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4159 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3443 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Ala133Thr ubiA_p.Ala133Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Ala137Gly ubiA_p.Ala137Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Ala15Pro ubiA_p.Ala15Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Ala15Val ubiA_p.Ala15Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Ala161Pro ubiA_p.Ala161Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 1 9477 35704 0.000421896424427802 0.000114964157806894 0.00107986688593449 0.999971992718106 0.999843963402622 0.999999290917266 0.8 0.28358206388191 0.994949236620532 NA NA NA 0 0 0.975 NA NA NA NA 4148 4975 False False 15.0697478104885 1.49093500364622 739.038051857485 0 0 0.000389169738041761 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 1 6556 26504 0.000609756097560975 0.000166162208307701 0.00156047520083291 0.999962271269571 0.999789807096406 0.999999044791703 0.8 0.28358206388191 0.994949236620532 NA NA NA 0 0 0.975 NA NA NA NA 3434 4087 False False 0 0 0 0 0 0 0 16.1708358755338 1.59970034177407 792.771744020614 0 0 0.000562514007570737 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Ala167Thr ubiA_p.Ala167Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Ala181Leu ubiA_p.Ala181Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4098 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3396 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Ala181Thr ubiA_p.Ala181Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 5 3 9476 35702 0.000527370530534753 0.000171257241502832 0.00123027414547083 0.99991597815432 0.999754472342108 0.99998267234027 0.625 0.244863216366551 0.914766585862746 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4073 4975 False False 6.27937244969748 1.22138615315282 40.4465543492688 0 0 0.000389210799037296 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 5 2 6555 26503 0.000762195121951219 0.000247527523788107 0.00177780526826415 0.999924542539143 0.999727448570663 0.999990861620785 0.714285714285714 0.290420863737342 0.963307433823914 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3371 4087 False False 0 0 0 0 0 0 0 10.1079328756674 1.6542054319611 106.199585900179 0 0 0.00056259979792051 0.999924542539143 0.999727448570663 0.999990861620785 8 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Ala181Val ubiA_p.Ala181Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 4 5 10 9 9471 35696 0.0010547410610695 0.00050590153672643 0.00193884812290577 0.99974793446296 0.999521555266748 0.999884733314884 0.526315789473684 0.288643247916998 0.755525310533804 0.444444444444444 0.136995662265166 0.787991493221131 0.307692307692307 0.0909203945720966 0.614261661750705 3.01518319079294 0.598160570641133 14.0069863592616 0.0990292094415484 126 4975 False False 4.18775443165687 1.52883610777882 11.6507322524626 0.000422163588390501 0.000115036965668997 0.00108055048140509 0.99974793446296 0.999521555266748 0.999884733314884 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 1 3 2 7 6558 26498 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999735898887002 0.999455926960675 0.999893811273379 0.222222222222222 0.0281449734778982 0.600093573716312 0.25 0.00630946320970987 0.805879550316756 0.125 0.0031597235312519 0.526509670875206 1.34685371556368 0.0256517274227575 16.7753915227222 0.587125422657302 250 4087 False False 0 0 0 0 0 0 0 1.15444604191173 0.116966185780849 6.06524023731598 0.000152462265589266 3.86000291520843e-06 0.000849169393567967 0.999735898887002 0.999455926960675 0.999893811273379 1 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Ala205Pro ubiA_p.Ala205Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Ala228Ser ubiA_p.Ala228Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 12 1 11 1 18 9480 35687 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99949586892592 0.999203372130377 0.999701193476901 0.0526315789473684 0.00133162880417942 0.260280654195214 0.0833333333333333 0.00210759323186022 0.384796165150944 0.0526315789473684 0.00133162880417942 0.260280654195214 0.342222861526659 0.0079533633099954 2.35525483112587 0.480146381947925 348 4975 False False 0.20913619315518 0.00502263873391001 1.32494056057363 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.99949586892592 0.999203372130377 0.999701193476901 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 12 1 11 1 17 6559 26488 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.99935861158272 0.998973272974466 0.999626324627714 0.0555555555555555 0.00140555616736942 0.272943599673368 0.0833333333333333 0.00210759323186022 0.384796165150944 0.0555555555555555 0.00140555616736942 0.272943599673368 0.367129135538954 0.00853149184446298 2.52681477763685 0.480545192589441 234 4087 False False 0 0 0 0 0 0 0 0.237554146525205 0.00568691332380032 1.51658119210468 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.99935861158272 0.998973272974466 0.999626324627714 1 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Ala237Thr ubiA_p.Ala237Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 3 9478 35702 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.99991597815432 0.999754472342108 0.99998267234027 0.5 0.118117248757025 0.881882751242974 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4068 4975 False False 3.76682844481958 0.504418797674528 28.1425087484132 0 0 0.000389128685709026 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 3 6558 26502 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999886813808715 0.999669257903365 0.999976657677988 0.4 0.0527449505263169 0.853367200365326 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3365 4087 False False 0 0 0 0 0 0 0 2.69411405916437 0.224966079471659 23.5225659748306 0 0 0.00056234250533983 0.999886813808715 0.999669257903365 0.999976657677988 2 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Ala237Val ubiA_p.Ala237Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 47 11 9434 35694 0.00495728298702668 0.00364463134753265 0.00658674341548076 0.999691919899173 0.999448826618347 0.999846197812 0.810344827586206 0.685949138406158 0.901336183157913 NA NA NA 0 0 0.284914152918154 NA NA NA NA 4096 4975 False False 16.1660724266193 8.25937532308559 34.5862788455547 0 0 0.000390943219834225 0.999691919899173 0.999448826618347 0.999846197812 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 29 7 6531 26498 0.00442073170731707 0.00296257223192387 0.00634278475638182 0.999735898887002 0.999455926960675 0.999893811273379 0.805555555555555 0.639751983824974 0.918056360234791 NA NA NA 0 0 0.409616397225003 NA NA NA NA 3394 4087 False False 0 0 0 0 0 0 0 16.8086707351751 7.2001311168916 45.4400473260538 0 0 0.00056466664560962 0.999735898887002 0.999455926960675 0.999893811273379 20 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Ala249Gly ubiA_p.Ala249Gly 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 1 0 3 1 9478 35704 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999971992718106 0.999843963402622 0.999999290917266 0.75 0.194120449683243 0.99369053679029 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0965804828807022 Inf 0.20979129318549 173 4975 False False 11.3011183794049 0.90722384791697 591.183089908516 0.000105496360375567 2.67093302808208e-06 0.000587646375974446 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3426 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Ala249Ser ubiA_p.Ala249Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 146.54949493291 1 1480 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3411 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Ala249Thr ubiA_p.Ala249Thr 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 0 1 40 16 9441 35689 0.00421896424427803 0.00301574918138985 0.00574064600943082 0.999551883489707 0.999272388596077 0.99974384169233 0.714285714285714 0.577901281040923 0.827048243965804 0 0 0.975 0 0 0.205907214207822 0 0 147.095918818528 1 2818.5 4975 False False 9.45053490096388 5.17294706082075 18.0830702250397 0 0 0.000390653412828861 0.999551883489707 0.999272388596077 0.99974384169233 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 0 1 18 7 6542 26498 0.00274390243902439 0.00162699615274529 0.00433309514094649 0.999735898887002 0.999455926960675 0.999893811273379 0.72 0.506123178193744 0.879283311495933 0 0 0.975 0 0 0.409616397225003 0 0 157.58673567665 1 2276.5 4087 False False 0 0 0 0 0 0 0 10.4154256016071 4.14837467452455 29.5158788571342 0 0 0.000563717458502632 0.999735898887002 0.999455926960675 0.999893811273379 65 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Ala249Val ubiA_p.Ala249Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 2 9479 35703 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999943985436213 0.999797670939776 0.99999321630447 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 146.564919965648 1 1480 4975 False False 3.76653655448887 0.272970929153834 51.9466713138689 0 0 0.000389087642036349 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 2 6558 26503 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999924542539143 0.999727448570663 0.999990861620785 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 157.232794181633 1 2276.5 4087 False False 0 0 0 0 0 0 0 4.04132357426044 0.292866339798886 55.7129032982466 0 0 0.00056234250533983 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Ala278Val ubiA_p.Ala278Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4071 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3369 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 1 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Ala34Val ubiA_p.Ala34Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 8 1 9473 35704 0.000843792848855605 0.000364358012393849 0.00166192766222289 0.999971992718106 0.999843963402622 0.999999290917266 0.888888888888888 0.517503485082663 0.9971908632534 NA NA NA 0 0 0.975 NA NA NA NA 4074 4975 False False 30.1522221049298 4.04116295283628 1328.54716994439 0 0 0.000389334034028122 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 8 0 6552 26505 0.00121951219512195 0.000526641184096925 0.00240150352406598 1 0.999860832946126 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 3372 4087 False False 0 0 0 0 0 0 0 Inf 6.902469478901 Inf 0 0 0.000562857326050777 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Ala35Ser ubiA_p.Ala35Ser 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 0 1 89 3 9392 35702 0.00938719544351861 0.00754527862333571 0.0115392300820024 0.99991597815432 0.999754472342108 0.99998267234027 0.967391304347826 0.907650118447495 0.993224149528806 0 0 0.975 0 0 0.707598226178713 0 0 147.91530928811 1 2818.5 4975 False False 112.772501419647 37.3504079497581 555.942503068017 0 0 0.000392691131982143 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 0 1 23 1 6537 26504 0.00350609756097561 0.0022238236869373 0.00525625089693 0.999962271269571 0.999789807096406 0.999999044791703 0.958333333333333 0.788798316543026 0.99894564755453 0 0 0.975 0 0 0.975 0 0 157.742593680587 1 2276.5 4087 False False 0 0 0 0 0 0 0 93.2525623374636 15.1359212476358 3758.89091309448 0 0 0.000564148511293225 0.999962271269571 0.999789807096406 0.999999044791703 12 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Ala35Thr ubiA_p.Ala35Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 4 1 9477 35704 0.000421896424427802 0.000114964157806894 0.00107986688593449 0.999971992718106 0.999843963402622 0.999999290917266 0.8 0.28358206388191 0.994949236620532 0 0 0.975 0 0 0.975 0 0 146.59987623386 1 2818.5 4975 False False 15.0697478104885 1.49093500364622 739.038051857485 0 0 0.000389169738041761 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 0 6556 26505 0.000609756097560975 0.000166162208307701 0.00156047520083291 1 0.999860832946126 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3391 4087 False False 0 0 0 0 0 0 0 Inf 2.66797681781562 Inf 0 0 0.000562514007570737 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Ala38Ser ubiA_p.Ala38Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 4 1 9477 35704 0.000421896424427802 0.000114964157806894 0.00107986688593449 0.999971992718106 0.999843963402622 0.999999290917266 0.8 0.28358206388191 0.994949236620532 0 0 0.975 0 0 0.975 0 0 146.59987623386 1 2818.5 4975 False False 15.0697478104885 1.49093500364622 739.038051857485 0 0 0.000389169738041761 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 6557 26505 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 1 0.999860832946126 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3392 4087 False False 0 0 0 0 0 0 0 Inf 1.66990152933523 Inf 0 0 0.000562428243381166 1 0.999860832946126 1 4 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Ala38Thr ubiA_p.Ala38Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 14 4 9467 35701 0.00147663748549731 0.000807519189222099 0.00247630687876465 0.999887970872426 0.999713186009257 0.999969475016731 0.777777777777777 0.52362723426352 0.935907952282333 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4145 4975 False False 13.1988486320904 4.14362023846238 55.102479950484 0 0 0.000389580738275926 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 11 2 6549 26503 0.00167682926829268 0.000837354988859942 0.00299832542833478 0.999924542539143 0.999727448570663 0.999990861620785 0.846153846153846 0.545528944323442 0.980793328017471 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3431 4087 False False 0 0 0 0 0 0 0 22.2578256222324 4.85535811122366 206.07639163171 0 0 0.000563115090054247 0.999924542539143 0.999727448570663 0.999990861620785 3 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Ala38Val ubiA_p.Ala38Val 1 missense_variant (see "Genomic_coordinates" sheet) 2 3 2 1 35 11 9446 35694 0.00369159371374327 0.00257263665643651 0.00513040870946252 0.999691919899173 0.999448826618347 0.999846197812 0.760869565217391 0.612331089885928 0.87413860517743 0.666666666666666 0.0942993240502461 0.991596241340387 0.153846153846153 0.0192066719825284 0.454471055676557 7.55748464958712 0.393380727573889 444.566608746372 0.113066222870254 129 4975 False False 12.023271033434 5.96533204058225 26.2507472694096 0.0002116850127011 2.56370652690921e-05 0.000764467648082917 0.999691919899173 0.999448826618347 0.999846197812 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 11 7 6549 26498 0.00167682926829268 0.000837354988859942 0.00299832542833478 0.999735898887002 0.999455926960675 0.999893811273379 0.611111111111111 0.357451205893062 0.827014145210248 NA NA NA 0 0 0.409616397225003 NA NA NA NA 3373 4087 False False 0 0 0 0 0 0 0 6.35817900224679 2.24966845614738 19.3477101589619 0 0 0.000563115090054247 0.999735898887002 0.999455926960675 0.999893811273379 14 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Ala39Gly ubiA_p.Ala39Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 1 9478 35704 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999971992718106 0.999843963402622 0.999999290917266 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 4119 4975 False False 11.3011183794049 0.90722384791697 591.183089908516 0 0 0.000389128685709026 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 1 6557 26504 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 0.999962271269571 0.999789807096406 0.999999044791703 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 3409 4087 False False 0 0 0 0 0 0 0 12.1262772609425 0.973374031902014 634.171386087929 0 0 0.000562428243381166 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Ala39Ser ubiA_p.Ala39Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 16 1 9465 35704 0.00168758569771121 0.00096489905765009 0.00273909056442828 0.999971992718106 0.999843963402622 0.999999290917266 0.941176470588235 0.713110603332779 0.998511825608733 NA NA NA 0 0 0.975 NA NA NA NA 4155 4975 False False 60.355414685684 9.37367510668151 2497.03440038238 0 0 0.000389663042518041 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 12 1 6548 26504 0.00182926829268292 0.000945555636841848 0.00319318105848117 0.999962271269571 0.999789807096406 0.999999044791703 0.923076923076923 0.639702564732122 0.998054371502653 NA NA NA 0 0 0.975 NA NA NA NA 3440 4087 False False 0 0 0 0 0 0 0 48.5717776420281 7.18300319901998 2053.57956659627 0 0 0.000563201063861023 0.999962271269571 0.999789807096406 0.999999044791703 6 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Ala80Thr ubiA_p.Ala80Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Ala94Thr ubiA_p.Ala94Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Arg240Cys ubiA_p.Arg240Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 18 5 9463 35700 0.00189853390992511 0.00112556752776016 0.00299884872837589 0.999859963590533 0.999673232250017 0.999954529045718 0.782608695652174 0.562969273763185 0.925396592351196 0 0 0.975 0 0 0.521823750104981 0 0 146.799855363017 1 2818.5 4975 False False 13.5813167071753 4.85831400191208 46.7921162089552 0 0 0.00038974538154329 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 11 3 6549 26502 0.00167682926829268 0.000837354988859942 0.00299832542833478 0.999886813808715 0.999669257903365 0.999976657677988 0.785714285714285 0.492024322951528 0.953420712110132 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3385 4087 False False 0 0 0 0 0 0 0 14.8379905329057 3.91773257228503 82.8137172341159 0 0 0.000563115090054247 0.999886813808715 0.999669257903365 0.999976657677988 4 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Arg240Leu ubiA_p.Arg240Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 1 9479 35704 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999971992718106 0.999843963402622 0.999999290917266 0.666666666666666 0.0942993240502461 0.991596241340387 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0965702950467794 Inf 0.209808781869688 177.5 4975 False False 7.53328410169849 0.392120325718966 443.147628387906 0.00010548523206751 2.670651284468e-06 0.000587584402906152 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3367 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Arg240Pro ubiA_p.Arg240Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.12104088004766 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 1 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Arg280Gly ubiA_p.Arg280Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4128 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3417 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Arg280His ubiA_p.Arg280His 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4085 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3382 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Arg82Gln ubiA_p.Arg82Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Arg88Ser ubiA_p.Arg88Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Asp265Tyr ubiA_p.Asp265Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4099 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3397 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 1 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Asp276Gly ubiA_p.Asp276Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Asp4Asn ubiA_p.Asp4Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Cys232Gly ubiA_p.Cys232Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 7 1 9474 35704 0.000738318742748655 0.00029689231210758 0.00152062336565454 0.999971992718106 0.999843963402622 0.999999290917266 0.875 0.473490329124793 0.996840276468748 NA NA NA 0 0 0.975 NA NA NA NA 4150 4975 False False 26.3804095419041 3.38816818189886 1181.46969547968 0 0 0.000389292947027732 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 0 6556 26505 0.000609756097560975 0.000166162208307701 0.00156047520083291 1 0.999860832946126 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3436 4087 False False 0 0 0 0 0 0 0 Inf 2.66797681781562 Inf 0 0 0.000562514007570737 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Cys232Ser ubiA_p.Cys232Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4129 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3418 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Gln8Arg ubiA_p.Gln8Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4066 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3362 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 4 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Glu149Asp ubiA_p.Glu149Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 329 4020 9152 31685 0.0347009809091867 0.0311077722825754 0.0385835861127202 0.887410726788965 0.884086520249302 0.890671772351619 0.0756495746148539 0.0679624638628053 0.0839121880291415 0 0 0.602364635616474 0 0 0.000917210809782563 0 0 5.24544695243334 0.581265421536302 NA NA False True 0.283339775119159 0.25186875745449 0.317919745281908 0 0 0.000402986901128888 0.887410726788965 0.884086520249302 0.890671772351619 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 4 0 4 247 3404 6313 23101 0.0376524390243902 0.0331764287139335 0.042545211245333 0.871571401622335 0.867483989756324 0.875577164692655 0.0676526978909887 0.0597178975613571 0.0762878469396386 0 0 0.602364635616474 0 0 0.00108310263682857 0 0 5.54458728540358 0.584095792626966 NA NA False True 1 1 1 0 0 1 1 0.265523150613612 0.231722668573983 0.30318487121767 0 0 0.000584159971697166 0.871571401622335 0.867483989756324 0.875577164692655 676 Not assoc w R 5) Not assoc w R No change yes 1 +Ethambutol ubiA p.Glu239Ala ubiA_p.Glu239Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4072 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3370 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Glu273Asp ubiA_p.Glu273Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 12 7 9469 35698 0.0012656892732834 0.000654165731961641 0.0022098595784263 0.999803949026747 0.999596102051779 0.999921173824063 0.631578947368421 0.383577923314405 0.8371141278449 NA NA NA 0 0 0.409616397225003 NA NA NA NA 4138 4975 False False 6.46283360741064 2.34503538754312 19.376902130279 0 0 0.00038949846879491 0.999803949026747 0.999596102051779 0.999921173824063 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3427 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 1 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Glu3Lys ubiA_p.Glu3Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Glu79Ala ubiA_p.Glu79Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Glu79Gln ubiA_p.Glu79Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Glu83Lys ubiA_p.Glu83Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Glu99Lys ubiA_p.Glu99Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Gly116Cys ubiA_p.Gly116Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Gly116Ser ubiA_p.Gly116Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Gly165Ala ubiA_p.Gly165Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4120 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Gly165Ser ubiA_p.Gly165Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 1 9478 35704 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999971992718106 0.999843963402622 0.999999290917266 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 4108 4975 False False 11.3011183794049 0.90722384791697 591.183089908516 0 0 0.000389128685709026 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 1 6557 26504 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 0.999962271269571 0.999789807096406 0.999999044791703 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 3403 4087 False False 0 0 0 0 0 0 0 12.1262772609425 0.973374031902014 634.171386087929 0 0 0.000562428243381166 0.999962271269571 0.999789807096406 0.999999044791703 2 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Gly165Val ubiA_p.Gly165Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 1 9479 35704 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999971992718106 0.999843963402622 0.999999290917266 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 4151 4975 False False 7.53328410169849 0.392120325718966 443.147628387906 0 0 0.000389087642036349 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3437 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Gly234Ala ubiA_p.Gly234Ala 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 0 1 13 1 9468 35704 0.00137116337939035 0.000730282374626527 0.00234358976784705 0.999971992718106 0.999843963402622 0.999999290917266 0.928571428571428 0.661315510068178 0.998193219340874 0 0 0.975 0 0 0.975 0 0 146.738910219317 1 1480 4975 False False 49.0232361639205 7.36241777084246 2060.63684291456 0 0 0.000389539599191658 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 0 1 12 1 6548 26504 0.00182926829268292 0.000945555636841848 0.00319318105848117 0.999962271269571 0.999789807096406 0.999999044791703 0.923076923076923 0.639702564732122 0.998054371502653 0 0 0.975 0 0 0.975 0 0 157.478253579981 1 2276.5 4087 False False 0 0 0 0 0 0 0 48.5717776420281 7.18300319901998 2053.57956659627 0 0 0.000563201063861023 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Gly234Val ubiA_p.Gly234Val 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 1 0 12 0 9469 35705 0.0012656892732834 0.000654165731961641 0.0022098595784263 1 0.999896689850119 1 1 0.735351530602948 1 1 0.025 1 1 0.025 1 Inf 0.096674977816448 Inf 0.209629219701162 166 4975 False False Inf 10.4733098222573 Inf 0.00010559662090813 2.67347139821088e-06 0.000588204722420116 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 6 0 6554 26505 0.000914634146341463 0.000335726224038477 0.00198970246660848 1 0.999860832946126 1 1 0.540741873560099 1 1 0.025 1 1 0.025 1 Inf 0.103678854093618 Inf 0.198275862068965 122 4087 False False 0 0 0 0 0 0 0 Inf 4.75965536954277 Inf 0.00015255530129672 3.86235836629056e-06 0.000849687394050823 1 0.999860832946126 1 6 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Gly268Asp ubiA_p.Gly268Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 18 173 9463 35532 0.00189853390992511 0.00112556752776016 0.00299884872837589 0.99515474023246 0.994378679841915 0.995848480173656 0.094240837696335 0.0568136451572327 0.144849801894769 NA NA NA 0 0 0.0210972746506848 NA NA NA NA NA NA False True 0.390676434351251 0.226058734556681 0.63643632420382 0 0 0.00038974538154329 0.99515474023246 0.994378679841915 0.995848480173656 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 15 143 6545 26362 0.00228658536585365 0.0012803316536391 0.00376857487312357 0.994604791548764 0.993647576822403 0.995450964522221 0.0949367088607595 0.0541140956163094 0.151747167295904 NA NA NA 0 0 0.0254664764133473 NA NA NA NA NA NA False True 0 1 1 0 0 1 0 0.422497288807449 0.230275023041618 0.721206713938765 0 0 0.000563459142866522 0.994604791548764 0.993647576822403 0.995450964522221 54 Not assoc w R 5) Not assoc w R No change yes 1 +Ethambutol ubiA p.Gly268Ser ubiA_p.Gly268Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4130 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3419 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Gly41Arg ubiA_p.Gly41Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 9478 35705 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 1 0.999896689850119 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4160 4975 False False Inf 1.55639137151076 Inf 0 0 0.000389128685709026 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3444 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 1 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Gly41His ubiA_p.Gly41His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4091 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Gly41Ser ubiA_p.Gly41Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4109 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Gly43Ser ubiA_p.Gly43Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4110 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.His197Asn ubiA_p.His197Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4152 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3438 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Ile150Met ubiA_p.Ile150Met 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4123 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3412 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Ile159Met ubiA_p.Ile159Met 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4139 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Ile162Leu ubiA_p.Ile162Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4132 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Ile162Thr ubiA_p.Ile162Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4092 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3388 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Ile170Val ubiA_p.Ile170Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4105 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3401 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 5 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Ile179Leu ubiA_p.Ile179Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4100 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Ile179Met ubiA_p.Ile179Met 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.096562813829025 Inf 0.209821626167397 198.5 4975 False False Inf 0.096562813829025 Inf 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.103599830448027 Inf 0.198397096627854 142 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Ile179Ser ubiA_p.Ile179Ser 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 1 0 8 1 9473 35704 0.000843792848855605 0.000364358012393849 0.00166192766222289 0.999971992718106 0.999843963402622 0.999999290917266 0.888888888888888 0.517503485082663 0.9971908632534 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0966314543106808 Inf 0.209703838151312 169 4975 False False 30.1522221049298 4.04116295283628 1328.54716994439 0.000105552037154317 2.67234263830968e-06 0.000587956437510075 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 4 1 6556 26504 0.000609756097560975 0.000166162208307701 0.00156047520083291 0.999962271269571 0.999789807096406 0.999999044791703 0.8 0.28358206388191 0.994949236620532 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.103643319688456 Inf 0.198330359033302 124.5 4087 False False 0 0 0 0 0 0 0 16.1708358755338 1.59970034177407 792.771744020614 0.000152508769254232 3.86118028152325e-06 0.000849428314837321 0.999962271269571 0.999789807096406 0.999999044791703 3 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Ile179Thr ubiA_p.Ile179Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 17 1 9464 35704 0.00179305980381816 0.00104485948824362 0.00286931523806543 0.999971992718106 0.999843963402622 0.999999290917266 0.944444444444444 0.727056400326631 0.99859444383263 NA NA NA 0 0 0.975 NA NA NA NA 4101 4975 False False 64.1344040574809 10.0428135452405 2641.99150882786 0 0 0.000389704207681396 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 14 1 6546 26504 0.00213414634146341 0.0011672334829473 0.00357814496544914 0.999962271269571 0.999789807096406 0.999999044791703 0.933333333333333 0.680515433421696 0.998313569758647 NA NA NA 0 0 0.975 NA NA NA NA 3398 4087 False False 0 0 0 0 0 0 0 56.6843874121601 8.62028984106342 2366.26924700375 0 0 0.000563373090255127 0.999962271269571 0.999789807096406 0.999999044791703 12 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Ile179Val ubiA_p.Ile179Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4093 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3389 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Ile259Val ubiA_p.Ile259Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 1 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Leu132His ubiA_p.Leu132His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Leu158Met ubiA_p.Leu158Met 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4081 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3379 4087 False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 0 0 0.000562256793434776 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Leu158Ser ubiA_p.Leu158Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 10 8 9471 35697 0.0010547410610695 0.00050590153672643 0.00193884812290577 0.999775941744853 0.999558563909973 0.999903262744512 0.555555555555555 0.307571658998756 0.7846984926127 0 0 0.975 0 0 0.369416647552819 0 0 146.663842955616 1 3243.5 4975 False False 4.71135571745327 1.6736042932984 13.7422817767466 0 0 0.000389416234052975 0.999775941744853 0.999558563909973 0.999903262744512 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 4 6560 26501 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 157.173142990263 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 6.12104088004766 0 0 0.000562171107654053 0.999849085078287 0.999613643356053 0.999958879281354 2 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Leu158Val ubiA_p.Leu158Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4133 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3422 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Leu172Pro ubiA_p.Leu172Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 4 3 9477 35702 0.000421896424427802 0.000114964157806894 0.00107986688593449 0.99991597815432 0.999754472342108 0.99998267234027 0.571428571428571 0.184051567640083 0.901011721557492 0 0 0.975 0 0 0.707598226178713 0 0 146.591683314664 1 2818.5 4975 False False 5.02296788716541 0.849591990333142 34.2786899066791 0 0 0.000389169738041761 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 3 6557 26502 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 0.999886813808715 0.999669257903365 0.999976657677988 0.5 0.118117248757025 0.881882751242974 0 0 0.975 0 0 0.707598226178713 0 0 157.250795899333 1 2276.5 4087 False False 0 0 0 0 0 0 0 4.04178740277565 0.541216472236634 30.185737988546 0 0 0.000562428243381166 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Leu172Val ubiA_p.Leu172Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 3 9479 35702 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.99991597815432 0.999754472342108 0.99998267234027 0.4 0.0527449505263169 0.853367200365326 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4121 4975 False False 2.51095403875232 0.209684820120099 21.9222407664312 0 0 0.000389087642036349 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 2 6559 26503 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999924542539143 0.999727448570663 0.999990861620785 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3410 4087 False False 0 0 0 0 0 0 0 2.02035371245616 0.0342397021387091 38.7759303485373 0 0 0.000562256793434776 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Leu178Val ubiA_p.Leu178Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 4 4 19 9 9462 35696 0.00200400801603206 0.00120696150945356 0.00312774546302964 0.99974793446296 0.999521555266748 0.999884733314884 0.678571428571428 0.476483593290381 0.841223962113846 0.5 0.157012770487058 0.842987229512941 0.307692307692307 0.0909203945720966 0.614261661750705 3.7725639399704 0.702522538290061 20.2551203422681 0.0654799775031243 103 4975 False False 7.96430165104863 3.43210759958097 19.9860459590792 0.000422564969364039 0.000115146350538661 0.00108157749893233 0.99974793446296 0.999521555266748 0.999884733314884 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 5 5 6555 26500 0.000762195121951219 0.000247527523788107 0.00177780526826415 0.999811356347858 0.999559824020536 0.9999387451734 0.5 0.187086028447398 0.812913971552601 0 0 0.707598226178713 0 0 0.521823750104981 0 0 9.78655965971577 1 2276.5 4087 False False 0 0 0 0 0 0 0 4.04271548436308 0.930054868102617 17.5613448179105 0 0 0.00056259979792051 0.999811356347858 0.999559824020536 0.9999387451734 2 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Leu198Val ubiA_p.Leu198Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Leu218Met ubiA_p.Leu218Met 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4140 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Leu224Phe ubiA_p.Leu224Phe 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4156 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3441 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 1 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Leu235Gln ubiA_p.Leu235Gln 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4157 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Leu235Met ubiA_p.Leu235Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4134 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3423 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Leu31Met ubiA_p.Leu31Met 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 9478 35705 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 1 0.999896689850119 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4069 4975 False False Inf 1.55639137151076 Inf 0 0 0.000389128685709026 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3366 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Leu31Pro ubiA_p.Leu31Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 15 5 9466 35700 0.00158211159160426 0.000885757734327454 0.00260811203671776 0.999859963590533 0.999673232250017 0.999954529045718 0.75 0.508954128292042 0.913428530898565 1 0.025 1 0.166666666666666 0.00421074451448947 0.641234578997674 Inf 0.0966920708997903 Inf 0.209599929151814 165 4975 False False 11.3141770547221 3.90749416451996 39.802669963162 0.000105630083447765 2.67431859409871e-06 0.000588391073757767 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 9 3 6551 26502 0.00137195121951219 0.000627529309645025 0.00260278604702639 0.999886813808715 0.999669257903365 0.999976657677988 0.75 0.42814153812181 0.945139355472007 1 0.025 1 0.25 0.00630946320970987 0.805879550316756 Inf 0.103714585766803 Inf 0.198221092757306 120 4087 False False 0 0 0 0 0 0 0 12.1364677148526 3.02738345259175 69.6537531371095 0.000152625152625152 3.86412684197919e-06 0.000850076309332636 0.999886813808715 0.999669257903365 0.999976657677988 6 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Leu31Val ubiA_p.Leu31Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 1 9479 35704 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999971992718106 0.999843963402622 0.999999290917266 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 4161 4975 False False 7.53328410169849 0.392120325718966 443.147628387906 0 0 0.000389087642036349 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3445 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 4 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Leu33Met ubiA_p.Leu33Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Leu33Val ubiA_p.Leu33Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4075 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3374 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 2 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Leu40Met ubiA_p.Leu40Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4118 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3408 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Leu40Phe ubiA_p.Leu40Phe 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4111 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3404 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Leu40Ser ubiA_p.Leu40Ser 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 0 1 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 146.553590101834 1 3243.5 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Lys174Arg ubiA_p.Lys174Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 2 9478 35703 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999943985436213 0.999797670939776 0.99999321630447 0.6 0.146632799634673 0.947255049473683 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4124 4975 False False 5.65040092846592 0.647137685918782 67.7491623796885 0 0 0.000389128685709026 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3413 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 1 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Lys174Thr ubiA_p.Lys174Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 23 5 9458 35700 0.00242590444045986 0.00153841761553811 0.00363783762977583 0.999859963590533 0.999673232250017 0.999954529045718 0.821428571428571 0.631066650580796 0.939357091180792 0 0 0.975 0 0 0.521823750104981 0 0 146.87728344291 1 2818.5 4975 False False 17.3630788750264 6.45355392332287 58.4868526377984 0 0 0.000389951381427405 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 19 4 6541 26501 0.00289634146341463 0.00174465970818583 0.00451931679095641 0.999849085078287 0.999613643356053 0.999958879281354 0.826086956521739 0.612188110045202 0.950492354694206 0 0 0.975 0 0 0.602364635616474 0 0 157.628567947515 1 2276.5 4087 False False 0 0 0 0 0 0 0 19.2447255771288 6.391877178255 77.7726608244999 0 0 0.000563803616355508 0.999849085078287 0.999613643356053 0.999958879281354 2 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Lys208Arg ubiA_p.Lys208Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Lys54Asn ubiA_p.Lys54Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4112 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3405 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Met128Ile ubiA_p.Met128Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.058895521352 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Met180Ile ubiA_p.Met180Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 11 5 9470 35700 0.00116021516717645 0.00057931301275248 0.00207499495108562 0.999859963590533 0.999673232250017 0.999954529045718 0.6875 0.413379363548641 0.889830045282882 0 0 0.975 0 0 0.521823750104981 0 0 146.691593095544 1 2818.5 4975 False False 8.2935586061246 2.6555370920474 30.4344624843374 0 0 0.000389457347082932 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 0 1 7 3 6553 26502 0.0010670731707317 0.000429122972600259 0.00219733487653492 0.999886813808715 0.999669257903365 0.999976657677988 0.7 0.347547149940002 0.933260488822265 0 0 0.975 0 0 0.707598226178713 0 0 157.346546968193 1 2276.5 4087 False False 0 0 0 0 0 0 0 9.4365939264459 2.15340403390833 56.5666757763692 0 0 0.000562771457148547 0.999886813808715 0.999669257903365 0.999976657677988 8 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Met180Thr ubiA_p.Met180Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 4 8 9477 35697 0.000421896424427802 0.000114964157806894 0.00107986688593449 0.999775941744853 0.999558563909973 0.999903262744512 0.333333333333333 0.0992460911495833 0.651124493581186 0 0 0.369416647552819 0 0 0.369416647552819 0 0 2.20717304973512 0.217718174003308 237 4975 False False 1.88334916112693 0.414922500512465 7.03130983507434 0 0 0.000389169738041761 0.999775941744853 0.999558563909973 0.999903262744512 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 4 1 6556 26504 0.000609756097560975 0.000166162208307701 0.00156047520083291 0.999962271269571 0.999789807096406 0.999999044791703 0.8 0.28358206388191 0.994949236620532 0 0 0.975 0 0 0.975 0 0 157.28656201851 1 2276.5 4087 False False 0 0 0 0 0 0 0 16.1708358755338 1.59970034177407 792.771744020614 0 0 0.000562514007570737 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Met180Val ubiA_p.Met180Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 2 1 76 9 9405 35696 0.00801603206412825 0.00632077093686047 0.0100231269547285 0.99974793446296 0.999521555266748 0.999884733314884 0.894117647058823 0.808496102482184 0.950427341975754 0.666666666666666 0.0942993240502461 0.991596241340387 0.181818181818181 0.0228311982999596 0.517755852360172 7.59085592769803 0.395118755934938 446.523252195197 0.112344248453837 128 4975 False False 32.0502805836139 16.0144675639699 72.9324141503223 0.00021260763261401 2.57488078031462e-05 0.000767798621773719 0.99974793446296 0.999521555266748 0.999884733314884 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 55 6 6505 26499 0.00838414634146341 0.00632215308853227 0.0108993032022667 0.99977362761743 0.99950734823901 0.999916920939814 0.901639344262295 0.798103808145629 0.963040005122148 1 0.158113883008419 1 0.25 0.0318540262499442 0.650855794412824 Inf 0.764886349938354 Inf 0.0388617392312276 63 4087 False False 0 0 0 0 0 0 0 37.3416602613374 16.0842400182233 105.919706949874 0.000307361303211925 3.72250474391674e-05 0.00110984905147684 0.99977362761743 0.99950734823901 0.999916920939814 11 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Met252Thr ubiA_p.Met252Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4102 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Phe140Val ubiA_p.Phe140Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4077 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Phe176Cys ubiA_p.Phe176Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4090 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3387 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Phe176Leu ubiA_p.Phe176Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 2 5 26 10 9455 35695 0.00274232675878071 0.00179213692288159 0.00401558030584103 0.999719927181067 0.999484996631079 0.999865686288203 0.722222222222222 0.548138854932161 0.857997552736598 0.285714285714285 0.0366925661760855 0.709579136262657 0.166666666666666 0.0208625254600923 0.484137748685967 1.51010047593865 0.14375420341007 9.22587633151983 0.642064608517621 529 4975 False False 9.81565309360127 4.57731142335494 22.8171659288497 0.000211483557153431 2.56126661115557e-05 0.000763740323531224 0.999719927181067 0.999484996631079 0.999865686288203 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 1 3 16 6 6544 26499 0.0024390243902439 0.00139473586445882 0.00395780883041526 0.99977362761743 0.99950734823901 0.999916920939814 0.727272727272727 0.497778798733651 0.892710751629603 0.25 0.00630946320970987 0.805879550316756 0.142857142857142 0.00361029686190058 0.578723197043195 1.34978606356968 0.0257075678947165 16.8119259932475 0.586412921194894 246 4087 False False 0 0 0 0 0 0 0 10.7982885085574 4.01119145742486 33.7283257646412 0.000152788388082505 3.86825958996662e-06 0.000850985164346494 0.99977362761743 0.99950734823901 0.999916920939814 7 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Phe176Ser ubiA_p.Phe176Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 3 2 9478 35703 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999943985436213 0.999797670939776 0.99999321630447 0.6 0.146632799634673 0.947255049473683 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0657881638833 1 2818.5 4975 False False 5.65040092846592 0.647137685918782 67.7491623796885 0 0 0.000389128685709026 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 6558 26504 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999962271269571 0.999789807096406 0.999999044791703 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 157.238712024072 1 1103 4087 False False 0 0 0 0 0 0 0 8.08295211954864 0.420719628662148 475.373667785977 0 0 0.00056234250533983 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Phe176Val ubiA_p.Phe176Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 0 9477 35705 0.000421896424427802 0.000114964157806894 0.00107986688593449 1 0.999896689850119 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 4078 4975 False False Inf 2.4863933079676 Inf 0 0 0.000389169738041761 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 0 6556 26505 0.000609756097560975 0.000166162208307701 0.00156047520083291 1 0.999860832946126 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3376 4087 False False 0 0 0 0 0 0 0 Inf 2.66797681781562 Inf 0 0 0.000562514007570737 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Phe186Leu ubiA_p.Phe186Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4135 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Phe238Cys ubiA_p.Phe238Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 7 0 9474 35705 0.000738318742748655 0.00029689231210758 0.00152062336565454 1 0.999896689850119 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 4144 4975 False False Inf 5.43056595882186 Inf 0 0 0.000389292947027732 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 0 6556 26505 0.000609756097560975 0.000166162208307701 0.00156047520083291 1 0.999860832946126 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3430 4087 False False 0 0 0 0 0 0 0 Inf 2.66797681781562 Inf 0 0 0.000562514007570737 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Phe238Leu ubiA_p.Phe238Leu 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 0 1 5 1 9476 35704 0.000527370530534753 0.000171257241502832 0.00123027414547083 0.999971992718106 0.999843963402622 0.999999290917266 0.833333333333333 0.358765421002325 0.99578925548551 0 0 0.975 0 0 0.975 0 0 146.615311442367 1 2818.5 4975 False False 18.8391726466863 2.10759583522104 886.708306345849 0 0 0.000389210799037296 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 0 1 5 1 6555 26504 0.000762195121951219 0.000247527523788107 0.00177780526826415 0.999962271269571 0.999789807096406 0.999999044791703 0.833333333333333 0.358765421002325 0.99578925548551 0 0 0.975 0 0 0.975 0 0 157.310497938471 1 1103 4087 False False 0 0 0 0 0 0 0 20.2166285278413 2.26137738039683 951.169010205643 0 0 0.00056259979792051 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Phe238Ser ubiA_p.Phe238Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0965729997991255 Inf 0.209804138541551 175.5 4975 False False Inf 0.707313928675496 Inf 0.00010548523206751 2.670651284468e-06 0.000587584402906152 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.103615625538654 Inf 0.198372852649407 128.5 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0.000152462265589266 3.86000291520843e-06 0.000849169393567967 1 0.999860832946126 1 1 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Phe238Tyr ubiA_p.Phe238Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4106 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Phe238Val ubiA_p.Phe238Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.096562813829025 Inf 0.209821626167397 198.5 4975 False False Inf 0.096562813829025 Inf 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Phe248Leu ubiA_p.Phe248Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 3 3 9478 35702 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.99991597815432 0.999754472342108 0.99998267234027 0.5 0.118117248757025 0.881882751242974 1 0.025 1 0.25 0.00630946320970987 0.805879550316756 Inf 0.0965750728053278 Inf 0.209800579889776 174 4975 False False 3.76682844481958 0.504418797674528 28.1425087484132 0.000105496360375567 2.67093302808208e-06 0.000587646375974446 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3363 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 3 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Phe59Cys ubiA_p.Phe59Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 1 9478 35704 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999971992718106 0.999843963402622 0.999999290917266 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 4141 4975 False False 11.3011183794049 0.90722384791697 591.183089908516 0 0 0.000389128685709026 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 1 6557 26504 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 0.999962271269571 0.999789807096406 0.999999044791703 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 3428 4087 False False 0 0 0 0 0 0 0 12.1262772609425 0.973374031902014 634.171386087929 0 0 0.000562428243381166 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Phe59Ser ubiA_p.Phe59Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 1 9479 35704 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999971992718106 0.999843963402622 0.999999290917266 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 4125 4975 False False 7.53328410169849 0.392120325718966 443.147628387906 0 0 0.000389087642036349 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 1 6558 26504 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 0.999962271269571 0.999789807096406 0.999999044791703 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 3414 4087 False False 0 0 0 0 0 0 0 8.08295211954864 0.420719628662148 475.373667785977 0 0 0.00056234250533983 0.999962271269571 0.999789807096406 0.999999044791703 2 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Phe89Val ubiA_p.Phe89Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Pro10Gln ubiA_p.Pro10Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Pro10Leu ubiA_p.Pro10Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Pro122Ala ubiA_p.Pro122Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.77983968475814 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Pro122Gln ubiA_p.Pro122Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 19 9481 35686 0 0 0.00038900558066021 0.999467861644027 0.999169124220115 0.999679588507228 0 0 0.176466911806965 NA NA NA 0 0 0.176466911806965 NA NA NA NA 4095 4975 False False 0 0 0.80673399727041 0 0 0.00038900558066021 0.999467861644027 0.999169124220115 0.999679588507228 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 18 6560 26487 0 0 0.000562171107654053 0.999320882852292 0.998926913664084 0.999597464048431 0 0 0.185301968137852 NA NA NA 0 0 0.185301968137852 NA NA NA NA 3393 4087 False False 0 0 0 0 0 0 0 0 0 0.918654117939294 0 0 0.000562171107654053 0.999320882852292 0.998926913664084 0.999597464048431 5 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Pro122Leu ubiA_p.Pro122Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Pro171Ser ubiA_p.Pro171Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 0 9477 35705 0.000421896424427802 0.000114964157806894 0.00107986688593449 1 0.999896689850119 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 4113 4975 False False Inf 2.4863933079676 Inf 0 0 0.000389169738041761 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 0 6556 26505 0.000609756097560975 0.000166162208307701 0.00156047520083291 1 0.999860832946126 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3406 4087 False False 0 0 0 0 0 0 0 Inf 2.66797681781562 Inf 0 0 0.000562514007570737 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Pro85Ser ubiA_p.Pro85Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Ser173Ala ubiA_p.Ser173Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 2 3 18 5 9463 35700 0.00189853390992511 0.00112556752776016 0.00299884872837589 0.999859963590533 0.999673232250017 0.999954529045718 0.782608695652174 0.562969273763185 0.925396592351196 0.4 0.0527449505263169 0.853367200365326 0.285714285714285 0.0366925661760855 0.709579136262657 2.51505864947691 0.210027574665131 21.9580805058817 0.282385250860967 262 4975 False False 13.5813167071753 4.85831400191208 46.7921162089552 0.000211304807184363 2.5591016926953e-05 0.000763094973690057 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 13 2 6547 26503 0.00198170731707317 0.00105558440345171 0.00338639575788259 0.999924542539143 0.999727448570663 0.999990861620785 0.866666666666666 0.595397303396627 0.983424086559916 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 2.02405681991751 0.0343024507984894 38.8489582884868 0.48436660562835 236 4087 False False 0 0 0 0 0 0 0 26.3127386589277 5.95348514992689 238.993487898742 0.00015271838729383 3.8664873302942e-06 0.000850595417196987 0.999924542539143 0.999727448570663 0.999990861620785 3 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Ser2Thr ubiA_p.Ser2Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4149 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3435 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Ser63Asn ubiA_p.Ser63Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4107 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3402 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Thr104Ala ubiA_p.Thr104Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4126 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3415 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Thr104Ile ubiA_p.Thr104Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4162 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3446 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 3 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Thr216Ala ubiA_p.Thr216Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4153 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3439 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Thr216Ser ubiA_p.Thr216Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Trp175Arg ubiA_p.Trp175Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4103 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3399 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Trp175Cys ubiA_p.Trp175Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 6 5 9475 35700 0.000632844636641704 0.000232277107744303 0.00137692358870305 0.999859963590533 0.999673232250017 0.999954529045718 0.545454545454545 0.233793597659345 0.832511905936292 NA NA NA 0 0 0.521823750104981 NA NA NA NA 4079 4975 False False 4.52137203166226 1.14932964148879 18.74197899831 0 0 0.000389251868698371 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 5 6557 26500 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 0.999811356347858 0.999559824020536 0.9999387451734 0.375 0.0852334141372535 0.755136783633448 NA NA NA 0 0 0.521823750104981 NA NA NA NA 3377 4087 False False 0 0 0 0 0 0 0 2.42488943114229 0.376458769236008 12.4652361555258 0 0 0.000562428243381166 0.999811356347858 0.999559824020536 0.9999387451734 8 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Trp175Gly ubiA_p.Trp175Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 24 12 9457 35693 0.00253137854656681 0.00162255461135746 0.00376416417214661 0.99966391261728 0.999412996653316 0.999826327071809 0.666666666666666 0.490297453348108 0.814438190174078 0 0 0.975 0 0 0.264648469397051 0 0 146.864043255027 1 2818.5 4975 False False 7.54848260547742 3.62862488796077 16.575468704767 0 0 0.000389992607538483 0.99966391261728 0.999412996653316 0.999826327071809 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 21 7 6539 26498 0.00320121951219512 0.00198266395382328 0.00488926302233576 0.999735898887002 0.999455926960675 0.999893811273379 0.75 0.551284548471391 0.893092008170773 0 0 0.975 0 0 0.409616397225003 0 0 157.658856123241 1 2276.5 4087 False False 0 0 0 0 0 0 0 12.1569047254931 4.97540933423194 33.8472836932499 0 0 0.000563976011094951 0.999735898887002 0.999455926960675 0.999893811273379 2 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Trp175Ser ubiA_p.Trp175Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 9479 35705 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 1 0.999896689850119 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4158 4975 False False Inf 0.707313928675496 Inf 0 0 0.000389087642036349 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3442 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Tyr103Ser ubiA_p.Tyr103Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Tyr243Cys ubiA_p.Tyr243Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.096562813829025 Inf 0.209821626167397 198.5 4975 False False Inf 0.096562813829025 Inf 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Tyr46_Tyr48del ubiA_p.Tyr46_Tyr48del 1 inframe_deletion (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4122 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Tyr46Cys ubiA_p.Tyr46Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Tyr48Phe ubiA_p.Tyr48Phe 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 9478 35705 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 1 0.999896689850119 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4082 4975 False False Inf 1.55639137151076 Inf 0 0 0.000389128685709026 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 6558 26505 0.000304878048780487 3.69242789199507e-05 0.00110088585400696 1 0.999860832946126 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3380 4087 False False 0 0 0 0 0 0 0 Inf 0.758877818966333 Inf 0 0 0.00056234250533983 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Val105Ala ubiA_p.Val105Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Val105Met ubiA_p.Val105Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Val107Met ubiA_p.Val107Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Val111Gly ubiA_p.Val111Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4076 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3375 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Val129Ile ubiA_p.Val129Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4094 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3390 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Val130Ala ubiA_p.Val130Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Val130Ile ubiA_p.Val130Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4131 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3420 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Val147Leu ubiA_p.Val147Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4117 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Val147Met ubiA_p.Val147Met 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 2 9480 35703 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999943985436213 0.999797670939776 0.99999321630447 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4136 4975 False False 1.88306962025316 0.0319145727646777 36.1783621216076 0 0 0.00038904660702099 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3424 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Val148Ala ubiA_p.Val148Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 31 9 9450 35696 0.00326969728931547 0.00222264895937465 0.00463789095997725 0.99974793446296 0.999521555266748 0.999884733314884 0.775 0.615488322696577 0.891603361015928 NA NA NA 0 0 0.336267116879942 NA NA NA NA 4087 4975 False False 13.0108877131099 6.04320730657273 31.0778321130751 0 0 0.000390281434571225 0.99974793446296 0.999521555266748 0.999884733314884 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 29 9 6531 26496 0.00442073170731707 0.00296257223192387 0.00634278475638182 0.999660441426146 0.999355510362951 0.999844720818052 0.763157894736842 0.597587639428509 0.885558295177469 NA NA NA 0 0 0.336267116879942 NA NA NA NA 3384 4087 False False 0 0 0 0 0 0 0 13.0724238248354 6.01940049947981 31.4042912014996 0 0 0.00056466664560962 0.999660441426146 0.999355510362951 0.999844720818052 4 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Val148Met ubiA_p.Val148Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4146 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3432 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Val14Ala ubiA_p.Val14Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 9481 35702 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.058895521352 1 2818.5 4975 False False 0 0 9.11552986995339 0 0 0.00038900558066021 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 6560 26502 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 21.5173342675905 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 9.77983968475814 0 0 0.000562171107654053 0.999886813808715 0.999669257903365 0.999976657677988 NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Val14Leu ubiA_p.Val14Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4147 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3433 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 2 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Val17Leu ubiA_p.Val17Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Val188Ala ubiA_p.Val188Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 56 10 9425 35695 0.00590654994198924 0.00446473813993274 0.00766337724522181 0.999719927181067 0.999484996631079 0.999865686288203 0.848484848484848 0.738958928711089 0.924875370060694 NA NA NA 0 0 0.30849710781876 NA NA NA NA 4070 4975 False False 21.2087002652519 10.7131911444293 46.6950093916373 0 0 0.000391316461263127 0.999719927181067 0.999484996631079 0.999865686288203 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 36 4 6524 26501 0.00548780487804878 0.00384646348156392 0.00758941639905408 0.999849085078287 0.999613643356053 0.999958879281354 0.9 0.7633626001239 0.97207458470578 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3368 4087 False False 0 0 0 0 0 0 0 36.558706315144 13.0942632113003 141.373462753527 0 0 0.000565272339837439 0.999849085078287 0.999613643356053 0.999958879281354 20 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Val188Gly ubiA_p.Val188Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4114 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 6559 26505 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 1 0.999860832946126 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3407 4087 False False 0 0 0 0 0 0 0 Inf 0.103599830448027 Inf 0 0 0.000562256793434776 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Val188Leu ubiA_p.Val188Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 1 9477 35704 0.000421896424427802 0.000114964157806894 0.00107986688593449 0.999971992718106 0.999843963402622 0.999999290917266 0.8 0.28358206388191 0.994949236620532 NA NA NA 0 0 0.975 NA NA NA NA 4080 4975 False False 15.0697478104885 1.49093500364622 739.038051857485 0 0 0.000389169738041761 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 6557 26505 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 1 0.999860832946126 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3378 4087 False False 0 0 0 0 0 0 0 Inf 1.66990152933523 Inf 0 0 0.000562428243381166 1 0.999860832946126 1 NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Val18Phe ubiA_p.Val18Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.0594558180883 1 2818.5 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Val221Leu ubiA_p.Val221Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4083 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Val229Ala ubiA_p.Val229Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 15 2 9466 35703 0.00158211159160426 0.000885757734327454 0.00260811203671776 0.999943985436213 0.999797670939776 0.99999321630447 0.88235294117647 0.635590837898749 0.985420683159697 0.5 0.012579117093425 0.987420882906574 0.333333333333333 0.00840375865961264 0.905700675949754 3.77170927530107 0.0480441004711567 295.359602417801 0.375242054512092 325 4975 False False 28.287819564758 6.57556021914265 253.393579174235 0.000105630083447765 2.67431859409871e-06 0.000588391073757767 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 6 2 6554 26503 0.000914634146341463 0.000335726224038477 0.00198970246660848 0.999924542539143 0.999727448570663 0.999990861620785 0.75 0.349144205587175 0.968145973750055 0 0 0.975 0 0 0.841886116991581 0 0 157.328519708266 1 2276.5 4087 False False 0 0 0 0 0 0 0 12.1313701556301 2.1683237669748 123.038341532173 0 0 0.000562685614442453 0.999924542539143 0.999727448570663 0.999990861620785 9 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Val229Gly ubiA_p.Val229Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4143 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Val229Leu ubiA_p.Val229Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4115 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Val27Ala ubiA_p.Val27Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 0 9477 35705 0.000421896424427802 0.000114964157806894 0.00107986688593449 1 0.999896689850119 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 4086 4975 False False Inf 2.4863933079676 Inf 0 0 0.000389169738041761 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 0 6556 26505 0.000609756097560975 0.000166162208307701 0.00156047520083291 1 0.999860832946126 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3383 4087 False False 0 0 0 0 0 0 0 Inf 2.66797681781562 Inf 0 0 0.000562514007570737 1 0.999860832946126 1 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Val27Leu ubiA_p.Val27Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Val283Ala ubiA_p.Val283Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 1 9479 35704 0.000210948212213901 2.55478281666916e-05 0.000761807540356844 0.999971992718106 0.999843963402622 0.999999290917266 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 4088 4975 False False 7.53328410169849 0.392120325718966 443.147628387906 0 0 0.000389087642036349 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Val283Leu ubiA_p.Val283Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 9480 35704 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999971992718106 0.999843963402622 0.999999290917266 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4142 4975 False False 3.76624472573839 0.0479745002090283 294.932792118969 0 0 0.00038904660702099 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 6559 26504 0.000152439024390243 3.85941450126536e-06 0.000849039992117216 0.999962271269571 0.999789807096406 0.999999044791703 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3429 4087 False False 0 0 0 0 0 0 0 4.04085988717792 0.0514701624188962 316.380494544091 0 0 0.000562256793434776 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Val44Ala ubiA_p.Val44Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 146.534073146605 1 1480 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 157.184975087717 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Val44Ile ubiA_p.Val44Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Val44Leu ubiA_p.Val44Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 9481 35703 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4089 4975 False False 0 0 20.0594558180883 0 0 0.00038900558066021 0.999943985436213 0.999797670939776 0.99999321630447 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3386 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Val49Ala ubiA_p.Val49Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Val49Ile ubiA_p.Val49Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 77 9477 35628 0.000421896424427802 0.000114964157806894 0.00107986688593449 0.997843439294216 0.997305395465678 0.998297712716848 0.0493827160493827 0.0136170870880631 0.121638139486511 NA NA NA 0 0 0.046778068160404 NA NA NA NA NA NA False True 0.195294417516639 0.0518602943669766 0.52083554128695 0 0 0.000389169738041761 0.997843439294216 0.997305395465678 0.998297712716848 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 4 72 6556 26433 0.000609756097560975 0.000166162208307701 0.00156047520083291 0.997283531409168 0.996580262873228 0.997873942127992 0.0526315789473684 0.0145245583391564 0.129309158452984 NA NA NA 0 0 0.0499440837058546 NA NA NA NA NA NA False True 0 0 0 0 0 1 0 0.223993288590604 0.0593835951681019 0.59912701705397 0 0 0.000562514007570737 0.997283531409168 0.996580262873228 0.997873942127992 6 Not assoc w R Previous WHO guidance 4) Not assoc w R - Interim DOWN from NotAwR to NotAwRI yes Prev. WHO 3 +Ethambutol ubiA p.Val49Phe ubiA_p.Val49Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 6560 26504 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 0 0 0.975 0 0 0.975 0 0 0.975 0 0 157.190891134799 1 1103 4087 False False 0 0 0 0 0 0 0 0 0 157.190891134799 0 0 0.000562171107654053 0.999962271269571 0.999789807096406 0.999999044791703 NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Val55Ala ubiA_p.Val55Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 9481 35701 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.70515331951781 0.585898468981268 412.5 4975 False False 0 0 5.70515331951781 0 0 0.00038900558066021 0.999887970872426 0.999713186009257 0.999969475016731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 6560 26503 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.518144632979 1 2276.5 4087 False False 0 0 0 0 0 0 0 0 0 21.518144632979 0 0 0.000562171107654053 0.999924542539143 0.999727448570663 0.999990861620785 NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Val55Gly ubiA_p.Val55Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 12 3 9469 35702 0.0012656892732834 0.000654165731961641 0.0022098595784263 0.99991597815432 0.999754472342108 0.99998267234027 0.8 0.519108866193147 0.956687994894163 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4127 4975 False False 15.0816348083218 4.06856516872326 83.2567952298776 0 0 0.00038949846879491 0.99991597815432 0.999754472342108 0.99998267234027 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 8 1 6552 26504 0.00121951219512195 0.000526641184096925 0.00240150352406598 0.999962271269571 0.999789807096406 0.999999044791703 0.888888888888888 0.517503485082663 0.9971908632534 NA NA NA 0 0 0.975 NA NA NA NA 3416 4087 False False 0 0 0 0 0 0 0 32.3614163614163 4.33671337572761 1425.06187007021 0 0 0.000562857326050777 0.999962271269571 0.999789807096406 0.999999044791703 2 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Val55Leu ubiA_p.Val55Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 14 0 9467 35705 0.00147663748549731 0.000807519189222099 0.00247630687876465 1 0.999896689850119 1 1 0.768364238349883 1 1 0.025 1 1 0.025 1 Inf 0.0966953992698264 Inf 0.209594226639807 164 4975 False False Inf 12.5061331267982 Inf 0.0001056189269117 2.67403613581623e-06 0.000588328943526898 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 10 0 6550 26505 0.00152439024390243 0.000731238785140689 0.00280161526425175 1 0.999860832946126 1 1 0.691502892181239 1 NA NA NA NA NA NA NA NA NA NA 3421 4087 False False 0 0 0 0 0 0 0 Inf 9.06910085377678 Inf 0 0 0.000563029142491623 1 0.999860832946126 1 2 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Val55Met ubiA_p.Val55Met 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 1 9478 35704 0.000316422318320852 6.52586432989292e-05 0.000924439074635535 0.999971992718106 0.999843963402622 0.999999290917266 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 4104 4975 False False 11.3011183794049 0.90722384791697 591.183089908516 0 0 0.000389128685709026 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 1 6557 26504 0.000457317073170731 9.43197059742867e-05 0.0013358871802567 0.999962271269571 0.999789807096406 0.999999044791703 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 3400 4087 False False 0 0 0 0 0 0 0 12.1262772609425 0.973374031902014 634.171386087929 0 0 0.000562428243381166 0.999962271269571 0.999789807096406 0.999999044791703 1 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Val5Ala ubiA_p.Val5Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 9480 35705 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 1 0.999896689850119 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4154 4975 False False Inf 0.096562813829025 Inf 0 0 0.00038904660702099 1 0.999896689850119 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Val5Gly ubiA_p.Val5Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 9481 35700 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.10982832991351 0.590980565810755 492 4975 False False 0 0 4.10982832991351 0 0 0.00038900558066021 0.999859963590533 0.999673232250017 0.999954529045718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 6560 26500 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.40943166615857 0.590385352956204 278 4087 False False 0 0 0 0 0 0 0 0 0 4.40943166615857 0 0 0.000562171107654053 0.999811356347858 0.999559824020536 0.9999387451734 1 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Val75Ala ubiA_p.Val75Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethambutol ubiA p.Val96Ala ubiA_p.Val96Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 9481 35704 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 0 0 0.975 0 0 0.975 0 0 0.975 0 0 146.538167885573 1 1480 4975 False False 0 0 146.538167885573 0 0 0.00038900558066021 0.999971992718106 0.999843963402622 0.999999290917266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethambutol ubiA p.Val96Met ubiA_p.Val96Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 23 0 23 1 25 9480 35680 0.00010547410610695 2.67036960028714e-06 0.000587522442907813 0.999299817952667 0.998966565499085 0.999546829455204 0.0384615384615384 0.00097328789333503 0.196369646762539 0 0 0.148185128915224 0 0 0.137185171530712 0 0 0.654911428408148 0.00814897052242731 51 4975 False False 0.150548523206751 0.00367011474722141 0.919963110620938 0 0 0.00038904660702099 0.999299817952667 0.998966565499085 0.999546829455204 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 13 0 13 0 14 6560 26491 0 0 0.000562171107654053 0.999471797774004 0.999113925067086 0.999711197799087 0 0 0.231635761650116 0 0 0.24705263800047 0 0 0.231635761650116 0 0 1.32543811097122 0.0853059820334418 82.5 4087 False False 0 0 0 0 0 0 0 0 0 1.21779664057642 0 0 0.000562171107654053 0.999471797774004 0.999113925067086 0.999711197799087 1 3) Uncertain significance No change no 1 +Ethionamide ethA c.1011C>T ethA_c.1011C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.1020C>A ethA_c.1020C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0761899451219867 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.1023A>C ethA_c.1023A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.1032G>A ethA_c.1032G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 6 0 5206 15487 0.00115118956254796 0.000422579736688136 0.00250395844332671 1 0.999761836368682 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 3.50093622554567 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.1047T>C ethA_c.1047T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.1053G>T ethA_c.1053G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.1068C>T ethA_c.1068C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.19247409791798 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 17 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.1083G>A ethA_c.1083G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.1089C>T ethA_c.1089C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.1095G>T ethA_c.1095G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.97179044329303 0.0378514560716107 232.854636669753 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.-10G>A ethA_c.-10G>A 1 upstream_gene_variant 4327483 1 1 0 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 115.699581334225 1 815 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 629 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 51 3) Uncertain significance No change no 1 +Ethionamide ethA c.1107C>T ethA_c.1107C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.1137C>T ethA_c.1137C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.1146C>T ethA_c.1146C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.114G>C ethA_c.114G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.19247409791798 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.2999762698034 NA NA NA NA NA NA 46 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.1161C>T ethA_c.1161C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.19247409791798 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.-11A>C ethA_c.-11A>C 1 upstream_gene_variant 4327484 1 4 3 1 3 1 5209 15486 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.999935429715245 0.999640290494779 0.999998365223265 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 8.91879439431752 0.715852821346612 466.959465949029 0.0517824898023508 107.5 2233 False False 8.91879439431752 0.715852821346612 466.959465949029 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 1 3) Uncertain significance No change no 1 +Ethionamide ethA c.-11A>G ethA_c.-11A>G 1 upstream_gene_variant 4327484 1 12 7 5 55 13 5157 15474 0.010552570990023 0.00795925820989337 0.0137137286918515 0.999160586298185 0.998565004766387 0.999552974256682 0.808823529411764 0.695298244670496 0.894089116336718 0.583333333333333 0.276669685682105 0.848347770191569 0.35 0.153909204784541 0.592188534532828 4.20081442699243 1.14703843840072 16.7959588822038 0.014278084633385 71 2233 False False 12.6947688727793 6.83924507666497 25.349368900194 0.00135553834237025 0.000545164914045063 0.00279092014609028 0.999160586298185 0.998565004766387 0.999552974256682 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 2 1 2 2 2168 3788 0.000921658986175115 0.000111636674590768 0.0033253435449308 0.999472295514512 0.998095063429584 0.999936086148442 0.5 0.067585986488543 0.932414013511457 0.666666666666666 0.0942993240502461 0.991596241340387 0.5 0.067585986488543 0.932414013511457 3.49446494464944 0.181777526236227 205.957935024476 0.301214629885456 90 1065 False False 0 0 0 0 0 0 0 1.74723247232472 0.126540110696744 24.1244851777313 0.000921658986175115 0.000111636674590768 0.0033253435449308 0.999472295514512 0.998095063429584 0.999936086148442 128 3) Uncertain significance No change no 1 +Ethionamide ethA c.-11A>T ethA_c.-11A>T 1 upstream_gene_variant 4327484 1 2 2 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.55810577429468 Inf 0.0633939383341096 130.5 2233 False False Inf 0.55810577429468 Inf 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA c.1209T>C ethA_c.1209T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.1216T>C ethA_c.1216T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0761899451219867 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.1224C>T ethA_c.1224C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.1245C>T ethA_c.1245C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.97179044329303 0.0378514560716107 232.854636669753 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.1269C>T ethA_c.1269C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.126C>T ethA_c.126C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.1272A>C ethA_c.1272A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.12C>T ethA_c.12C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.-12T>C ethA_c.-12T>C 1 upstream_gene_variant 4327485 1 2 1 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 2.97179044329303 0.0378514560716107 232.854636669753 0.440205269357083 400.5 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethA c.1302C>T ethA_c.1302C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.1305C>G ethA_c.1305C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.1305C>T ethA_c.1305C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.1314C>T ethA_c.1314C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.19247409791798 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.1326G>T ethA_c.1326G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 143 211 5069 15276 0.0274366845740598 0.0231722381866442 0.032240699342428 0.986375669916704 0.984423430292749 0.988141910773824 0.403954802259887 0.352419478010275 0.457110665564778 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.0424006529794 1.63595513476437 2.54384102650774 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 34 27 2136 3763 0.0156682027649769 0.0108744540073486 0.0218264651060431 0.99287598944591 0.989651745715379 0.995300136009189 0.557377049180327 0.424459512439998 0.684535859024068 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.21844222499653 1.29506680449651 3.83404841759172 NA NA NA NA NA NA 476 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.1338G>A ethA_c.1338G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.19247409791798 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 2170 3787 0 0 0.00169850036174098 0.999208443271767 0.997688494809834 0.999836732216022 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.22663965322398 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.1344G>A ethA_c.1344G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 6 5212 15481 0 0 0.000707516179821284 0.99961257829147 0.999156938222445 0.999857810215121 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.52357746319564 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.1383C>T ethA_c.1383C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.1384C>T ethA_c.1384C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.1386A>G ethA_c.1386A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.1389T>C ethA_c.1389T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.1401C>G ethA_c.1401C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.1455C>T ethA_c.1455C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 5211 15485 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.48579927077336 0.0251793916671698 28.5526337681963 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 2 2169 3788 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999472295514512 0.998095063429584 0.999936086148442 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.87321346242508 0.0147995228023146 16.7833115850342 NA NA NA NA NA NA 26 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.1461G>T ethA_c.1461G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.1464G>C ethA_c.1464G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0761899451219867 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.-16T>C ethA_c.-16T>C 1 upstream_gene_variant 4327489 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1242 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 588 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 2 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA c.171C>T ethA_c.171C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 17 5212 15470 0 0 0.000707516179821284 0.998902305159165 0.998243064068552 0.999360426383401 0 0 0.195064322969093 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.719611878295978 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 13 2170 3777 0 0 0.00169850036174098 0.996569920844327 0.994141602714116 0.99817240212944 0 0 0.24705263800047 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.571869099974644 NA NA NA NA NA NA 25 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.180C>T ethA_c.180C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.-19A>G ethA_c.-19A>G 1 upstream_gene_variant 4327492 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1309 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 634 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA c.1A>C ethA_c.1A>C 1 initiator_codon_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0761899451219867 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.234C>T ethA_c.234C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.249G>A ethA_c.249G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.-24A>T ethA_c.-24A>T 1 upstream_gene_variant 4327497 1 4 0 4 0 4 5212 15483 0 0 0.000707516179821284 0.99974171886098 0.999338830952079 0.999929622742193 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 4.5014696306354 0.578098957200874 462.5 2233 False False 0 0 4.5014696306354 0 0 0.000707516179821284 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.2999762698034 0.53686319604546 244.5 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 1 3) Uncertain significance No change no 1 +Ethionamide ethA c.24C>T ethA_c.24C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 4 12 5208 15475 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.99922515658294 0.998646896080726 0.999599565042795 0.25 0.0726620382528822 0.523770819896127 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.990463389656938 0.232723294816419 3.27003116948113 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 75 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.261C>T ethA_c.261C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.-28C>T ethA_c.-28C>T 1 upstream_gene_variant 4327501 1 6 0 6 2 7 5210 15480 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999548008006715 0.999068946905294 0.99981825708278 0.222222222222222 0.0281449734778982 0.600093573716312 0 0 0.4592581264399 0 0 0.409616397225003 0 0 2.52438334624971 0.3476398216979 359.5 2233 False False 0.848916918014806 0.0860206666092397 4.46043370684753 0 0 0.000707787682982558 0.999548008006715 0.999068946905294 0.99981825708278 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 598 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0 0 0.00170006591133688 1 0.999027154404229 1 2 3) Uncertain significance No change no 1 +Ethionamide ethA c.-30G>T ethA_c.-30G>T 1 upstream_gene_variant 4327503 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA c.312G>T ethA_c.312G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.-32C>T ethA_c.-32C>T 1 upstream_gene_variant 4327505 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 3 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA c.342C>T ethA_c.342C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.-35T>C ethA_c.-35T>C 1 upstream_gene_variant 4327508 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1243 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA c.360C>T ethA_c.360C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.-36T>C ethA_c.-36T>C 1 upstream_gene_variant 4327509 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1321 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 646 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide ethA c.372C>T ethA_c.372C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.375G>A ethA_c.375G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.381C>T ethA_c.381C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.390C>A ethA_c.390C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.393C>T ethA_c.393C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.-39T>C ethA_c.-39T>C 1 upstream_gene_variant 4327512 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethA c.3G>A ethA_c.3G>A 1 initiator_codon_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 5212 15483 0 0 0.000707516179821284 0.99974171886098 0.999338830952079 0.999929622742193 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.5014696306354 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.3G>C ethA_c.3G>C 1 initiator_codon_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 5211 15485 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.48579927077336 0.0251793916671698 28.5526337681963 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 2 2169 3788 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999472295514512 0.998095063429584 0.999936086148442 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.87321346242508 0.0147995228023146 16.7833115850342 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.-41T>G ethA_c.-41T>G 1 upstream_gene_variant 4327514 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA c.426C>T ethA_c.426C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.19247409791798 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.432C>T ethA_c.432C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 8 5211 15479 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99948343772196 0.998982421476308 0.999776959534822 0.111111111111111 0.00280913674659921 0.482496514917337 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.371305891383611 0.00836999418610458 2.77069344974123 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.438C>A ethA_c.438C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.97179044329303 0.0378514560716107 232.854636669753 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.-43C>T ethA_c.-43C>T 1 upstream_gene_variant 4327516 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA c.447G>C ethA_c.447G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0761899451219867 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.462G>A ethA_c.462G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.-46C>T ethA_c.-46C>T 1 upstream_gene_variant 4327519 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethA c.471C>T ethA_c.471C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.477G>A ethA_c.477G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 5211 15485 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.48579927077336 0.0251793916671698 28.5526337681963 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.477G>T ethA_c.477G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.2999762698034 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.-47T>C ethA_c.-47T>C 1 upstream_gene_variant 4327520 1 2 1 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 2.97179044329303 0.0378514560716107 232.854636669753 0.440205269357083 400.5 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 6 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA c.480G>T ethA_c.480G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.-49_-30delTGTCGACATCTCGTTGACGG ethA_c.-49_-30delTGTCGACATCTCGTTGACGG 1 upstream_gene_variant 4327502 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1397 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA c.-50G>A ethA_c.-50G>A 1 upstream_gene_variant 4327523 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethA c.513C>T ethA_c.513C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.519C>T ethA_c.519C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.528G>A ethA_c.528G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.537C>T ethA_c.537C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.546C>T ethA_c.546C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 45 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.576G>A ethA_c.576G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.576G>C ethA_c.576G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.579G>A ethA_c.579G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.600G>A ethA_c.600G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.60C>T ethA_c.60C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 5211 15485 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.48579927077336 0.0251793916671698 28.5526337681963 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.615G>C ethA_c.615G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.618G>A ethA_c.618G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.630C>G ethA_c.630C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 5 5210 15482 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999677148576225 0.999246734667469 0.999895162977301 0.285714285714285 0.0366925661760855 0.709579136262657 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.18863723608445 0.113129903278746 7.26455938498844 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.639G>T ethA_c.639G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.651C>T ethA_c.651C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.-6G>A ethA_c.-6G>A 1 upstream_gene_variant 4327479 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA c.-6G>C ethA_c.-6G>C 1 upstream_gene_variant 4327479 1 0 0 0 0 4 5212 15483 0 0 0.000707516179821284 0.99974171886098 0.999338830952079 0.999929622742193 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1279 2233 False False 0 0 4.5014696306354 0 0 0.000707516179821284 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 2170 3786 0 0 0.00169850036174098 0.998944591029023 0.997299958285064 0.999712364080324 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 605 1065 False False 0 0 0 0 0 0 0 0 0 2.6454264678615 0 0 0.00169850036174098 0.998944591029023 0.997299958285064 0.999712364080324 15 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA c.708C>T ethA_c.708C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0761899451219867 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.726C>T ethA_c.726C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0761899451219867 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.732G>A ethA_c.732G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.19247409791798 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.735C>G ethA_c.735C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 11 123 5201 15364 0.0021105141980046 0.00105401717787221 0.00377314786388412 0.99205785497514 0.990531174512238 0.993395076444062 0.0820895522388059 0.0416917540449976 0.142133486429151 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.264183091744395 0.128400005852806 0.489971841990264 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 5 14 2165 3776 0.00230414746543778 0.000748560476988087 0.00536885389822181 0.996306068601583 0.993809970169066 0.997979066953146 0.263157894736842 0.0914657849076665 0.512029345345872 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.622896733751237 0.175373925514018 1.83339685322559 NA NA NA NA NA NA 354 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.744C>T ethA_c.744C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.747G>T ethA_c.747G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.19247409791798 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.759C>T ethA_c.759C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 0 NA NA NA 1 2 5211 15485 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.48579927077336 0.0251793916671698 28.5526337681963 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 NA NA NA 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.771A>G ethA_c.771A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.2999762698034 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.-7T>C ethA_c.-7T>C 1 upstream_gene_variant 4327480 1 108 47 61 53 67 5159 15420 0.0101688411358403 0.00762617822291838 0.0132802341584402 0.995673790921418 0.994509077858156 0.99664572158467 0.441666666666666 0.351108110604171 0.535173003683592 0.435185185185185 0.340028289642196 0.533987472982056 0.412280701754386 0.320917171457704 0.508316219772417 2.3029625133858 1.53775116340046 3.42970642370137 3.06957424303569e-05 29 2233 True False 2.3643943492462 1.61481941608621 3.44629269913334 0.00902804456396465 0.00664079518858698 0.0119874923494003 0.995673790921418 0.994509077858156 0.99664572158467 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance 1 95 42 53 47 59 2123 3731 0.0216589861751152 0.0159565666248753 0.0286987041457803 0.9844327176781 0.979964758028303 0.988128897440186 0.443396226415094 0.346920446572657 0.54311619052539 0.442105263157894 0.340239208492715 0.54767983672482 0.415841584158415 0.318569640760329 0.518181795671333 1.39267145993121 0.902878126313184 2.13593800734123 0.131835300636393 52 1065 False False 0 0 0 0 0 0 0 1.3999776459599 0.92982913951851 2.09748057854981 0.0193995381062355 0.0140163617674577 0.0261328682534135 0.9844327176781 0.979964758028303 0.988128897440186 243 Assoc w RI Evidence from ALL dataset only 2) Assoc w R - Interim No change yes ALL only 1 +Ethionamide ethA c.-7T>G ethA_c.-7T>G 1 upstream_gene_variant 4327480 1 1 0 1 2 2 5210 15485 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.99987085943049 0.99953357854254 0.999984360095269 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 115.714289717243 1 496.5 2233 False False 2.97216890595009 0.215371636513233 40.9716636776753 0 0 0.000707787682982558 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 68.0751891811639 1 405 1065 False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 0 0 0.0016992827759538 0.999736147757256 0.998530795728906 0.999993319861894 4 3) Uncertain significance No change no 1 +Ethionamide ethA c.819C>T ethA_c.819C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.81C>T ethA_c.81C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.19247409791798 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 2170 3787 0 0 0.00169850036174098 0.999208443271767 0.997688494809834 0.999836732216022 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.22663965322398 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.831C>T ethA_c.831C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.876A>G ethA_c.876A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.87C>T ethA_c.87C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.894C>T ethA_c.894C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.906C>T ethA_c.906C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.19247409791798 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.912C>A ethA_c.912C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.942C>T ethA_c.942C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 5212 15482 0 0 0.000707516179821284 0.999677148576225 0.999246734667469 0.999895162977301 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.24289311550326 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 5 2170 3785 0 0 0.00169850036174098 0.998680738786279 0.996923992057454 0.999571505100005 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.90544972133019 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.969C>G ethA_c.969C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 15 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.981G>A ethA_c.981G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.987A>G ethA_c.987A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0761899451219867 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.993C>A ethA_c.993C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.993C>T ethA_c.993C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 4 5211 15483 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99974171886098 0.999338830952079 0.999929622742193 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.742803684513529 0.0150842538989179 7.50989306640636 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.99C>A ethA_c.99C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA c.99C>T ethA_c.99C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 3 5210 15484 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999806289145735 0.999434000080036 0.999960050383188 0.4 0.0527449505263169 0.853367200365326 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.98131797824696 0.165426255296508 17.2953159846476 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethA deletion ethA_deletion 1 feature_ablation (see "Genomic_coordinates" sheet) 1 1 0 1 34 31 5178 15456 0.00652340752110514 0.00452175606360518 0.00910398409556301 0.997998321172596 0.997159969582944 0.998639563655124 0.523076923076923 0.395442461428413 0.648540319239169 0 0 0.975 0 0 0.11218874692237 0 0 116.210467949986 1 815 2233 False False 3.27380106903898 1.95014123483534 5.51393530398842 0 0 0.000712160247488952 0.997998321172596 0.997159969582944 0.998639563655124 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 21 14 2149 3776 0.00967741935483871 0.00600017304096532 0.0147551047030148 0.996306068601583 0.993809970169066 0.997979066953146 0.6 0.421117721882099 0.761291889546658 NA NA NA 0 0 0.231635761650116 NA NA NA NA 621 1065 False False 0 0 0 0 0 0 0 2.63564448580735 1.27499376653865 5.61528532537457 0 0 0.00171508384379734 0.996306068601583 0.993809970169066 0.997979066953146 48 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA LoF ethA_LoF 1 LoF (see "Genomic_coordinates" sheet) 1 1291 658 633 1270 936 3942 14551 0.243668457405986 0.232063905607138 0.255560715751088 0.939562213469361 0.93569359359426 0.943264685807884 0.575702629193109 0.55476242553296 0.596441438541585 0.509682416731216 0.48203017334727 0.537290483416216 0.412797992471769 0.388494385217809 0.437423397995149 3.8370583572384 3.41509839552606 4.31026512279834 1.09282999613772e-111 5 2233 True False 5.00845865476763 4.56563450300162 5.49431052394584 0.143043478260869 0.133046018866796 0.153496353161645 0.939562213469361 0.93569359359426 0.943264685807884 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 623 321 302 545 440 1625 3350 0.251152073732718 0.233020891380446 0.269957672285901 0.883905013192612 0.873277337967613 0.893936569436836 0.553299492385786 0.521624599296122 0.584654891206318 0.515248796147672 0.475209596744365 0.555142847838579 0.421813403416557 0.386430667570234 0.457804339568633 2.19123790117167 1.84567784821964 2.60131133801031 8.97528743739543e-20 6 1065 True False 0 0 0 0 0 0 0 2.5534965034965 2.21703863074422 2.94134393277326 0.164953751284686 0.148721416172381 0.182202395175617 0.883905013192612 0.873277337967613 0.893936569436836 NA 1) Assoc w R UP from AwRI to AwR yes 4 +Ethionamide ethA p.Ala107Ser ethA_p.Ala107Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Ala112Gly ethA_p.Ala112Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 1 6 5211 15481 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99961257829147 0.999156938222445 0.999857810215121 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.521823750104981 0 0 0.4592581264399 0 0 3.24330636341996 0.33984240868832 355.5 2233 False False 0.495138489093584 0.0107661625367428 4.08269117192464 0 0 0.000707651905360176 0.99961257829147 0.999156938222445 0.999857810215121 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 68.0751891811639 1 405 1065 False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 0 0 0.0016992827759538 0.999736147757256 0.998530795728906 0.999993319861894 34 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ala112Val ethA_p.Ala112Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1244 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Ala128fs ethA_p.Ala128fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 5211 15485 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8263323782973 1 815 2233 False False 1.48579927077336 0.0251793916671698 28.5526337681963 0 0 0.000707651905360176 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Ala12Val ethA_p.Ala12Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ala152Val ethA_p.Ala152Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ala175Thr ethA_p.Ala175Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Ala185fs ethA_p.Ala185fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Ala185Glu ethA_p.Ala185Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Ala185Gly ethA_p.Ala185Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1245 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 589 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Ala185Val ethA_p.Ala185Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 2 1 2 1 5210 15486 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 5.9447216890595 0.309382652589367 349.949104522224 0.158265844695452 166.5 2233 False False 5.9447216890595 0.309382652589367 349.949104522224 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 3 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ala187fs ethA_p.Ala187fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1297 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 622 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Ala187Glu ethA_p.Ala187Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ala187Val ethA_p.Ala187Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 2 2 3 2 5209 15485 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.99987085943049 0.99953357854254 0.999984360095269 0.6 0.146632799634673 0.947255049473683 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 2.97273948934536 0.215412974397121 40.9797844744598 0.264688051471407 338.5 2233 False False 4.45910923401804 0.510601005330275 53.3693689348625 0.000383803492611782 4.64837636131093e-05 0.00138573531807565 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 2 2 2168 3788 0.000921658986175115 0.000111636674590768 0.0033253435449308 0.999472295514512 0.998095063429584 0.999936086148442 0.5 0.067585986488543 0.932414013511457 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.873616236162361 0.0148063432989592 16.7910536461884 1 405 1065 False False 0 0 0 0 0 0 0 1.74723247232472 0.126540110696744 24.1244851777313 0.000461041954817888 1.16725035605811e-05 0.00256605588112533 0.999472295514512 0.998095063429584 0.999936086148442 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ala199Val ethA_p.Ala199Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1187 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Ala19Glu ethA_p.Ala19Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 2.97179044329303 0.0378514560716107 232.854636669753 0.440205269357083 400.5 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Ala19Thr ethA_p.Ala19Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1381 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 681 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Ala19Val ethA_p.Ala19Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 2 1 5210 15486 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 0.666666666666666 0.0942993240502461 0.991596241340387 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 2.97236084452975 0.0378587198701314 232.899239987393 0.440151175069926 381.5 2233 False False 5.9447216890595 0.309382652589367 349.949104522224 0.000191901746305891 4.8585197621771e-06 0.00106873920290263 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ala20Asp ethA_p.Ala20Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 2.97179044329303 0.0378514560716107 232.854636669753 0.440205269357083 400.5 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ala20dup ethA_p.Ala20dup 1 inframe_insertion (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1345 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Ethionamide ethA p.Ala20fs ethA_p.Ala20fs 1 frameshift (see "Genomic_coordinates" sheet) 2 1 0 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 115.699581334225 1 815 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 558 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Ala20Pro ethA_p.Ala20Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ala20Ser ethA_p.Ala20Ser 1 missense_variant (see "Genomic_coordinates" sheet) 2 2 1 1 3 4 5209 15483 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.99974171886098 0.999338830952079 0.999929622742193 0.428571428571428 0.0989882784425078 0.815948432359917 0.5 0.012579117093425 0.987420882906574 0.2 0.00505076337946806 0.716417936118089 2.97235553849107 0.0378586509042838 232.898827895352 0.440151686929874 385 2233 False False 2.2292666538683 0.326438409930677 13.182222747906 0.00019193857965451 4.85945229729366e-06 0.00106894424519385 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ala20Val ethA_p.Ala20Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 5210 15486 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 115.721748393509 1 815 2233 False False 5.9447216890595 0.309382652589367 349.949104522224 0 0 0.000707787682982558 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 68.0751891811639 1 405 1065 False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 0 0 0.0016992827759538 0.999736147757256 0.998530795728906 0.999993319861894 2 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ala222_Ile338del ethA_p.Ala222_Ile338del 1 inframe_deletion (see "Genomic_coordinates" sheet) 0 0 0 0 7 0 5205 15487 0.00134305448963929 0.000540142673187124 0.00276523543039201 1 0.999761836368682 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 1246 2233 False False Inf 4.28681262397718 Inf 0 0 0.000708467353397108 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Ethionamide ethA p.Ala222Thr ethA_p.Ala222Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1387 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 685 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ala222Val ethA_p.Ala222Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1367 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ala234Asp ethA_p.Ala234Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 2.97179044329303 0.0378514560716107 232.854636669753 0.440205269357083 400.5 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ala237dup ethA_p.Ala237dup 1 inframe_insertion (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1322 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Ethionamide ethA p.Ala237fs ethA_p.Ala237fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Ala247fs ethA_p.Ala247fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 2 1 5210 15486 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 1219 2233 False False 5.9447216890595 0.309382652589367 349.949104522224 0 0 0.000707787682982558 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 565 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 4 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Ala247Pro ethA_p.Ala247Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 3 6 5209 15481 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.99961257829147 0.999156938222445 0.999857810215121 0.333333333333333 0.0748546314196918 0.700704943791459 0.333333333333333 0.00840375865961264 0.905700675949754 0.142857142857142 0.00361029686190058 0.578723197043195 1.48598579381839 0.0251825508002003 28.5562077619545 1 815 2233 False False 1.48598579381839 0.240373448133868 6.9606999827616 0.00019193857965451 4.85945229729366e-06 0.00106894424519385 0.99961257829147 0.999156938222445 0.999857810215121 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 2170 3787 0 0 0.00169850036174098 0.999208443271767 0.997688494809834 0.999836732216022 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 68.0079825895614 1 289.5 1065 False False 0 0 0 0 0 0 0 0 0 4.22663965322398 0 0 0.00169850036174098 0.999208443271767 0.997688494809834 0.999836732216022 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ala248Asp ethA_p.Ala248Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1254 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Ala248dup ethA_p.Ala248dup 1 inframe_insertion (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1255 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Ethionamide ethA p.Ala248fs ethA_p.Ala248fs 1 frameshift (see "Genomic_coordinates" sheet) 2 2 1 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 2.97179044329303 0.0378514560716107 232.854636669753 0.440205269357083 400.5 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Ala248Pro ethA_p.Ala248Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1360 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Ala252_Asp300del ethA_p.Ala252_Asp300del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.55810577429468 Inf 0.0633939383341096 130.5 2233 False False Inf 0.55810577429468 Inf 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Ethionamide ethA p.Ala304Val ethA_p.Ala304Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ala322Val ethA_p.Ala322Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1247 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ala335Asp ethA_p.Ala335Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 2 5211 15485 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 0.333333333333333 0.00840375865961264 0.905700675949754 0.5 0.012579117093425 0.987420882906574 0.333333333333333 0.00840375865961264 0.905700675949754 2.97159854154672 0.0378490118256412 232.839631577795 0.440223474266017 417 2233 False False 1.48579927077336 0.0251793916671698 28.5526337681963 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.74688796680497 0.0222439624669857 137.016358245527 1 405 1065 False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ala33Gly ethA_p.Ala33Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 12 0 12 2 13 5210 15474 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999160586298185 0.998565004766387 0.999552974256682 0.133333333333333 0.0165759134400836 0.404602696603372 0 0 0.264648469397051 0 0 0.24705263800047 0 0 1.06937348313974 0.0455670033115822 95 2233 False False 0.456931935626753 0.0500493304513424 2.01928071228607 0 0 0.000707787682982558 0.999160586298185 0.998565004766387 0.999552974256682 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 2 5 2168 3785 0.000921658986175115 0.000111636674590768 0.0033253435449308 0.998680738786279 0.996923992057454 0.999571505100005 0.285714285714285 0.0366925661760855 0.709579136262657 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.90720596253315 0.166121045971345 73 1065 False False 0 0 0 0 0 0 0 0.698339483394834 0.0664358722176252 4.27020900106932 0 0 0.00170006591133688 0.998680738786279 0.996923992057454 0.999571505100005 4 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ala33Pro ethA_p.Ala33Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1280 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 606 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ala341Glu ethA_p.Ala341Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 2 1 3 1 5209 15486 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.999935429715245 0.999640290494779 0.999998365223265 0.75 0.194120449683243 0.99369053679029 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 5.94586292954501 0.309442031422125 350.016117394062 0.158224983853206 160.5 2233 False False 8.91879439431752 0.715852821346612 466.959465949029 0.000383803492611782 4.64837636131093e-05 0.00138573531807565 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ala341Val ethA_p.Ala341Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 21 15 6 17 7 5195 15480 0.00326170376055257 0.00190117534393765 0.00521718370320826 0.999548008006715 0.999068946905294 0.99981825708278 0.708333333333333 0.489052186142167 0.873847911476308 0.714285714285714 0.478248881752886 0.887190596078059 0.681818181818181 0.451275572426229 0.861353478446202 7.44947064485081 2.72948142715121 23.4434633086654 1.10901572542328e-05 25 2233 True False 7.2366286264265 2.84980995295526 20.6473509059225 0.00287907869481765 0.00161226617794788 0.00474416344582533 0.999548008006715 0.999068946905294 0.99981825708278 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance 1 2 0 2 1 2 2169 3788 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999472295514512 0.998095063429584 0.999936086148442 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.30426475290156 0.536921227582843 261 1065 False False 0 0 0 0 0 0 0 0.87321346242508 0.0147995228023146 16.7833115850342 0 0 0.0016992827759538 0.999472295514512 0.998095063429584 0.999936086148442 17 Assoc w RI Evidence from ALL dataset only 2) Assoc w R - Interim No change yes ALL only 1 +Ethionamide ethA p.Ala352fs ethA_p.Ala352fs 1 frameshift (see "Genomic_coordinates" sheet) 1 35 8 27 16 31 5196 15456 0.00306983883346124 0.00175566480963699 0.00498045124723913 0.997998321172596 0.997159969582944 0.998639563655124 0.340425531914893 0.20864087822476 0.493132485214578 0.228571428571428 0.104210431947815 0.401363256107314 0.205128205128205 0.0929639272829956 0.364644240695119 0.881361731246257 0.345819895587389 1.9958433493695 0.847567662744613 489 2233 False False 1.5352752737838 0.783561179955278 2.89670186044326 0.00153727901614142 0.000663914236974251 0.00302679350130742 0.997998321172596 0.997159969582944 0.998639563655124 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 26 2 24 3 26 2167 3764 0.00138248847926267 0.000285193152965682 0.0040348522148252 0.993139841688654 0.989964327935836 0.99551396597316 0.103448275862068 0.0218637368298536 0.273515197892423 0.0769230769230769 0.00945539100371274 0.251302916695373 0.0714285714285714 0.00877049670352713 0.23503477317459 0.144746962005845 0.0165593340668837 0.584080835957897 0.00159653706522002 19 1065 False False 0 0 0 0 0 0 0 0.200418870469631 0.0387893709075178 0.655260622647238 0.000922083909635776 0.000111688152776852 0.00332687482132476 0.993139841688654 0.989964327935836 0.99551396597316 17 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Ala352Glu ethA_p.Ala352Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1340 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ala354fs ethA_p.Ala354fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.55810577429468 Inf 0.0633939383341096 130.5 2233 False False Inf 0.55810577429468 Inf 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.328088282833639 Inf 0.132525557754273 60 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Ala354Gly ethA_p.Ala354Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1248 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ala381Pro ethA_p.Ala381Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 27 4 23 119 121 5093 15366 0.0228319263238679 0.0189498454789991 0.0272602167528058 0.99218699554465 0.990671573437537 0.993512864244416 0.495833333333333 0.430889636438998 0.560881200467005 0.148148148148148 0.0418873964737672 0.337310864024244 0.032 0.00878643301350049 0.0799063775335207 0.524709959962096 0.131830110683932 1.53678926222527 0.271772113789831 344 2233 False False 2.9672131413559 2.27942248701808 3.86154170627634 0.000784775358053757 0.000213864951313762 0.00200810661359451 0.99218699554465 0.990671573437537 0.993512864244416 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 12 0 2158 3790 0.00552995391705069 0.00286057468269438 0.00963977234551449 1 0.999027154404229 1 1 0.735351530602948 1 1 0.025 1 1 0.025 1 Inf 0.0450111440405335 Inf 0.362918137502101 104 1065 False False 0 0 0 0 0 0 0 Inf 4.87213960657593 Inf 0.000463177396943029 1.17265676417349e-05 0.00257792869038761 1 0.999027154404229 1 486 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ala389Asp ethA_p.Ala389Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ala395Asp ethA_p.Ala395Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ala395fs ethA_p.Ala395fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Ala481Thr ethA_p.Ala481Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ala74Glu ethA_p.Ala74Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 5212 15483 0 0 0.000707516179821284 0.99974171886098 0.999338830952079 0.999929622742193 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 4.5014696306354 0.578098957200874 462.5 2233 False False 0 0 4.5014696306354 0 0 0.000707516179821284 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ala74Pro ethA_p.Ala74Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ala74Val ethA_p.Ala74Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ala76Asp ethA_p.Ala76Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 1 2 5211 15485 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 1.48579927077336 0.0251793916671698 28.5526337681963 1 815 2233 False False 1.48579927077336 0.0251793916671698 28.5526337681963 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.74688796680497 0.0222439624669857 137.016358245527 1 405 1065 False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 3 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ala76Val ethA_p.Ala76Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1188 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 547 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Ala89Glu ethA_p.Ala89Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 7 17 5205 15470 0.00134305448963929 0.000540142673187124 0.00276523543039201 0.998902305159165 0.998243064068552 0.999360426383401 0.291666666666666 0.126152088523691 0.510947813857832 0 0 0.975 0 0 0.195064322969093 0 0 115.71325796938 1 815 2233 False False 1.223823246878 0.428817157337632 3.10738331927642 0 0 0.000708467353397108 0.998902305159165 0.998243064068552 0.999360426383401 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 5 5 2165 3785 0.00230414746543778 0.000748560476988087 0.00536885389822181 0.998680738786279 0.996923992057454 0.999571505100005 0.5 0.187086028447398 0.812913971552601 0 0 0.975 0 0 0.521823750104981 0 0 68.1289260297405 1 405 1065 False False 0 0 0 0 0 0 0 1.74826789838337 0.401816597175933 7.6048231979945 0 0 0.00170241965449235 0.998680738786279 0.996923992057454 0.999571505100005 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ala90fs ethA_p.Ala90fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.55810577429468 Inf 0.0633939383341096 130.5 2233 False False Inf 0.55810577429468 Inf 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Ala90Thr ethA_p.Ala90Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Arg115Cys ethA_p.Arg115Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 115.669966941234 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Arg150_Pro160del ethA_p.Arg150_Pro160del 1 inframe_deletion (see "Genomic_coordinates" sheet) 0 0 0 0 33 3 5179 15484 0.00633154259401381 0.00436223314272292 0.00888044953266542 0.999806289145735 0.999434000080036 0.999960050383188 0.916666666666666 0.775310239443026 0.982473504076065 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1374 2233 False False 32.8874300057926 10.307673793666 168.018120213727 0 0 0.000712022787235984 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 2167 3790 0.00138248847926267 0.000285193152965682 0.0040348522148252 1 0.999027154404229 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 678 1065 False False 0 0 0 0 0 0 0 Inf 0.721991535026265 Inf 0 0 0.00170084976888778 1 0.999027154404229 1 14 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Ethionamide ethA p.Arg207Cys ethA_p.Arg207Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 2 1 2 3 5210 15484 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999806289145735 0.999434000080036 0.999960050383188 0.4 0.0527449505263169 0.853367200365326 0.666666666666666 0.0942993240502461 0.991596241340387 0.4 0.0527449505263169 0.853367200365326 5.94395393474088 0.309342694444577 349.90402525689 0.158293349107387 174 2233 False False 1.98131797824696 0.165426255296508 17.2953159846476 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.74688796680497 0.0222439624669857 137.016358245527 1 405 1065 False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 3 3) Uncertain significance No change no 1 +Ethionamide ethA p.Arg207fs ethA_p.Arg207fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 15.8222760528043 1 815 2233 False False 0 0 7.19247409791798 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 630 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Arg207Gly ethA_p.Arg207Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 57 36 21 36 24 5176 15463 0.00690713737528779 0.00484222673175067 0.00954968462837135 0.998450313165881 0.997695060668636 0.999006841908059 0.6 0.465405437311427 0.7243784212644651 0.631578947368421 0.493447033135367 0.755535994474188 0.6 0.465405437311427 0.7243784212644651 5.12132921174652 2.90680786446367 9.24096882787145 1.54136140049973e-09 15 2233 True False 4.4811630602782 2.59776131762928 7.8575219922345 0.00690713737528779 0.00484222673175067 0.00954968462837135 0.998450313165881 0.997695060668636 0.999006841908059 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 53 34 19 34 22 2136 3768 0.0156682027649769 0.0108744540073486 0.0218264651060431 0.99419525065963 0.991224655744321 0.996358725497634 0.607142857142857 0.467536927445786 0.735008737496271 0.641509433962264 0.498033223990566 0.7685690531287 0.607142857142857 0.467536927445786 0.735008737496271 3.15671200473092 1.74486635249657 5.87258428421007 4.27722231327611e-05 11 1065 True False 0 0 0 0 0 0 0 2.72625127681307 1.54404603453245 4.9057233666367 0.0156682027649769 0.0108744540073486 0.0218264651060431 0.99419525065963 0.991224655744321 0.996358725497634 19 Assoc w R 1) Assoc w R No change yes 1 +Ethionamide ethA p.Arg207His ethA_p.Arg207His 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 2 2 5210 15485 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.99987085943049 0.99953357854254 0.999984360095269 0.5 0.067585986488543 0.932414013511457 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8293686688623 1 815 2233 False False 2.97216890595009 0.215371636513233 40.9716636776753 0 0 0.000707787682982558 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 640 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0 0 0.00170006591133688 1 0.999027154404229 1 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Arg207Ser ethA_p.Arg207Ser 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 0 1 1 2 5211 15485 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 115.692124084117 1 815 2233 False False 1.48579927077336 0.0251793916671698 28.5526337681963 0 0 0.000707651905360176 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 601 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Arg218Trp ethA_p.Arg218Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Arg227Pro ethA_p.Arg227Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Arg239Gln ethA_p.Arg239Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 2 5211 15485 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 0.333333333333333 0.00840375865961264 0.905700675949754 0.5 0.012579117093425 0.987420882906574 0.333333333333333 0.00840375865961264 0.905700675949754 2.97159854154672 0.0378490118256412 232.839631577795 0.440223474266017 417 2233 False False 1.48579927077336 0.0251793916671698 28.5526337681963 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 2 2169 3788 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999472295514512 0.998095063429584 0.999936086148442 0.333333333333333 0.00840375865961264 0.905700675949754 0.5 0.012579117093425 0.987420882906574 0.333333333333333 0.00840375865961264 0.905700675949754 1.74642692485016 0.0222380917340097 136.980247384435 1 405 1065 False False 0 0 0 0 0 0 0 0.87321346242508 0.0147995228023146 16.7833115850342 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999472295514512 0.998095063429584 0.999936086148442 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Arg239Gly ethA_p.Arg239Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 2 3) Uncertain significance No change no 1 +Ethionamide ethA p.Arg239Trp ethA_p.Arg239Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 5210 15486 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 115.721748393509 1 815 2233 False False 5.9447216890595 0.309382652589367 349.949104522224 0 0 0.000707787682982558 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Arg245His ethA_p.Arg245His 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1256 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 591 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 7 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Arg258fs ethA_p.Arg258fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1281 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 607 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Arg259fs ethA_p.Arg259fs 1 frameshift (see "Genomic_coordinates" sheet) 1 4 2 2 4 2 5208 15485 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.99987085943049 0.99953357854254 0.999984360095269 0.666666666666666 0.222778095503512 0.956728131707258 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 2.97331029185867 0.215454328149436 40.9879090321904 0.264626900317166 336 2233 False False 5.94662058371735 0.851897563491887 65.8224106582454 0.000383877159309021 4.64926862896582e-05 0.00138600116078139 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 2 1 2 1 2168 3789 0.000921658986175115 0.000111636674590768 0.0033253435449308 0.999736147757256 0.998530795728906 0.999993319861894 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 3.49538745387453 0.181825522231654 206.012215468794 0.301129741671258 88 1065 False False 0 0 0 0 0 0 0 3.49538745387453 0.181825522231654 206.012215468794 0.000921658986175115 0.000111636674590768 0.0033253435449308 0.999736147757256 0.998530795728906 0.999993319861894 4 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Arg261Trp ethA_p.Arg261Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 115.699581334225 1 815 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethionamide ethA p.Arg270His ethA_p.Arg270His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Arg279* ethA_p.Arg279* 1 stop_gained (see "Genomic_coordinates" sheet) 1 3 1 2 2 3 5210 15484 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999806289145735 0.999434000080036 0.999960050383188 0.4 0.0527449505263169 0.853367200365326 0.333333333333333 0.00840375865961264 0.905700675949754 0.25 0.00630946320970987 0.805879550316756 1.48598848368522 0.0251825973021435 28.5562583562758 1 815 2233 False False 1.98131797824696 0.165426255296508 17.2953159846476 0.000191901746305891 4.8585197621771e-06 0.00106873920290263 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 2 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Arg292Gln ethA_p.Arg292Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Arg292* ethA_p.Arg292* 1 stop_gained (see "Genomic_coordinates" sheet) 1 2 2 0 13 3 5199 15484 0.00249424405218726 0.00132872751584936 0.0042614564942691 0.999806289145735 0.999434000080036 0.999960050383188 0.8125 0.543543453768388 0.959526266094054 1 0.158113883008419 1 0.4 0.0527449505263169 0.853367200365326 Inf 0.559177928198458 Inf 0.0632120890257099 114 2233 False False 12.9058152208758 3.54405343740996 70.606589755325 0.00038454143433955 4.65731447910975e-05 0.00138839834306103 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 3 0 2167 3790 0.00138248847926267 0.000285193152965682 0.0040348522148252 1 0.999027154404229 1 1 0.292401773821286 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.328239646677015 Inf 0.132447859973667 55 1065 False False 0 0 0 0 0 0 0 Inf 0.721991535026265 Inf 0.000922083909635776 0.000111688152776852 0.00332687482132476 1 0.999027154404229 1 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Arg303Pro ethA_p.Arg303Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Arg326Gln ethA_p.Arg326Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 7.19247409791798 0.577090863007554 439 2233 False False 0 0 7.19247409791798 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.2999762698034 0.53686319604546 244.5 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 3 3) Uncertain significance No change no 1 +Ethionamide ethA p.Arg38Pro ethA_p.Arg38Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Arg38Trp ethA_p.Arg38Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Arg404Leu ethA_p.Arg404Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 2 1 2 1 5210 15486 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 5.9447216890595 0.309382652589367 349.949104522224 0.158265844695452 166.5 2233 False False 5.9447216890595 0.309382652589367 349.949104522224 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Arg421fs ethA_p.Arg421fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Arg421* ethA_p.Arg421* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 115.699581334225 1 815 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 686 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 1 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Arg441Cys ethA_p.Arg441Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 2.97179044329303 0.0378514560716107 232.854636669753 0.440205269357083 400.5 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 3 3) Uncertain significance No change no 1 +Ethionamide ethA p.Arg441His ethA_p.Arg441His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Arg441Leu ethA_p.Arg441Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Arg441Pro ethA_p.Arg441Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1324 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 648 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 2 3) Uncertain significance No change no 1 +Ethionamide ethA p.Arg452fs ethA_p.Arg452fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1361 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 671 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 3 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Arg463fs ethA_p.Arg463fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 2 0 83 124 5129 15363 0.0159247889485802 0.0127034414626018 0.0197034040664839 0.991993284690385 0.990461010054498 0.993336147127216 0.400966183574879 0.333640266097436 0.471171260324428 1 0.158113883008419 1 0.0158730158730158 0.00192810976798256 0.0561622113344771 Inf 0.562377916863571 Inf 0.06267395592373 113 2233 False False 2.00493242095862 1.49689583594084 2.67378952179175 0.000389787565776651 4.72085688656728e-05 0.00140733001387404 0.991993284690385 0.990461010054498 0.993336147127216 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 33 52 2137 3738 0.0152073732718894 0.0104905711282456 0.0212910363416637 0.986279683377308 0.98204613457613 0.989736491080465 0.388235294117647 0.284378448827455 0.500116256941008 NA NA NA 0 0 0.0684822087033195 NA NA NA NA 608 1065 False False 0 0 0 0 0 0 0 1.11005723336093 0.692700729470983 1.75626091824605 0 0 0.0017247063275812 0.986279683377308 0.98204613457613 0.989736491080465 9 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Arg466fs ethA_p.Arg466fs 1 frameshift (see "Genomic_coordinates" sheet) 1 6 4 2 4 2 5208 15485 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.99987085943049 0.99953357854254 0.999984360095269 0.666666666666666 0.222778095503512 0.956728131707258 0.666666666666666 0.222778095503512 0.956728131707258 0.666666666666666 0.222778095503512 0.956728131707258 5.94662058371735 0.851897563491887 65.8224106582454 0.0385321016822305 93.5 2233 False False 5.94662058371735 0.851897563491887 65.8224106582454 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Arg466Trp ethA_p.Arg466Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Arg469Pro ethA_p.Arg469Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1273 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Arg469Trp ethA_p.Arg469Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 2 3 5210 15484 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999806289145735 0.999434000080036 0.999960050383188 0.4 0.0527449505263169 0.853367200365326 0 0 0.707598226178713 0 0 0.707598226178713 0 0 7.19523598146917 0.577130575021777 453 2233 False False 1.98131797824696 0.165426255296508 17.2953159846476 0 0 0.000707787682982558 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 582 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0 0 0.00170006591133688 1 0.999027154404229 1 4 3) Uncertain significance No change no 1 +Ethionamide ethA p.Arg470fs ethA_p.Arg470fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.55810577429468 Inf 0.0633939383341096 130.5 2233 False False Inf 0.55810577429468 Inf 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Arg470Ser ethA_p.Arg470Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1189 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Arg479fs ethA_p.Arg479fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Arg479Pro ethA_p.Arg479Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.55810577429468 Inf 0.0633939383341096 130.5 2233 False False Inf 0.55810577429468 Inf 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Arg54Cys ethA_p.Arg54Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 1 5209 15486 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.999935429715245 0.999640290494779 0.999998365223265 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 115.743923948461 1 496.5 2233 False False 8.91879439431752 0.715852821346612 466.959465949029 0 0 0.000707923512718415 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 68.0751891811639 1 405 1065 False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 0 0 0.0016992827759538 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Arg54fs ethA_p.Arg54fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1298 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 623 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Arg54His ethA_p.Arg54His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Arg54Leu ethA_p.Arg54Leu 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 1 0 3 0 5209 15487 0.000575594781273983 0.000118717215010897 0.00168120176197813 1 0.999761836368682 1 1 0.292401773821286 1 1 0.025 1 1 0.025 1 Inf 0.0762191927925782 Inf 0.251727303473933 201.5 2233 False False Inf 1.22809956796298 Inf 0.00019193857965451 4.85945229729366e-06 0.00106894424519385 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 664 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0 0 0.00170006591133688 1 0.999027154404229 1 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Arg54Ser ethA_p.Arg54Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1274 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Arg65Pro ethA_p.Arg65Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 3 5211 15484 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999806289145735 0.999434000080036 0.999960050383188 0.25 0.00630946320970987 0.805879550316756 0.5 0.012579117093425 0.987420882906574 0.25 0.00630946320970987 0.805879550316756 2.97140663980042 0.037846567579671 232.824626481779 0.440241680638111 419 2233 False False 0.990468879933474 0.0188633706776044 12.3373543450537 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Arg65* ethA_p.Arg65* 1 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1368 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 675 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Arg67His ethA_p.Arg67His 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.2999762698034 0.53686319604546 244.5 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Arg72Trp ethA_p.Arg72Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Arg96Lys ethA_p.Arg96Lys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1181 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Asn114fs ethA_p.Asn114fs 1 frameshift (see "Genomic_coordinates" sheet) 1 31 14 17 22 20 5190 15467 0.00422102839600921 0.00264712925735376 0.00638375303230951 0.9987085943049 0.998006229813624 0.999211003011252 0.523809523809523 0.364177970921332 0.679959491139774 0.451612903225806 0.273164986003735 0.639657672839183 0.411764705882352 0.24647073529775 0.593030567029151 2.45424458800861 1.11910843645293 5.29365313835872 0.0201326288213352 85 2233 False False 3.27816955684007 1.70528077256088 6.33681608062595 0.0026902382782475 0.00147153455639287 0.00450964715419743 0.9987085943049 0.998006229813624 0.999211003011252 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 17 9 8 15 8 2155 3782 0.00691244239631336 0.0038738510690251 0.0113754323453532 0.997889182058047 0.995845105987758 0.999088271930771 0.652173913043478 0.427343963036494 0.83623640162505 0.529411764705882 0.278118300331106 0.770167312734009 0.529411764705882 0.278118300331106 0.770167312734009 1.97436194895591 0.674960811741515 5.88876611517048 0.205380111792361 78 1065 False False 0 0 0 0 0 0 0 3.29060324825986 1.30684941025811 8.97467308652207 0.00415896487985212 0.00190345337478532 0.00788026705919753 0.997889182058047 0.995845105987758 0.999088271930771 27 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Asn226fs ethA_p.Asn226fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 1 1 2 1 5210 15486 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 0.666666666666666 0.0942993240502461 0.991596241340387 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 2.97236084452975 0.0378587198701314 232.899239987393 0.440151175069926 381.5 2233 False False 5.9447216890595 0.309382652589367 349.949104522224 0.000191901746305891 4.8585197621771e-06 0.00106873920290263 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Asn242Asp ethA_p.Asn242Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0762045661509476 Inf 0.251763455406319 213.5 2233 False False Inf 0.55810577429468 Inf 0.000191901746305891 4.8585197621771e-06 0.00106873920290263 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0448036218670314 Inf 0.363987246182245 113 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0.000461041954817888 1.16725035605811e-05 0.00256605588112533 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Asn242fs ethA_p.Asn242fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Asn242Thr ethA_p.Asn242Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1331 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Asn287_Leu333del ethA_p.Asn287_Leu333del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 9 1 8 4 8 5208 15479 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.99948343772196 0.998982421476308 0.999776959534822 0.333333333333333 0.0992460911495833 0.651124493581186 0.111111111111111 0.00280913674659921 0.482496514917337 0.111111111111111 0.00280913674659921 0.482496514917337 0.371519777265745 0.00837481215821752 2.77228972173654 0.465090756618187 423 2233 False False 1.48607910906298 0.327343181309975 5.54928881094045 0.000191975427145325 4.860385190457e-06 0.00106914936617667 0.99948343772196 0.998982421476308 0.999776959534822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 3 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Ethionamide ethA p.Asn287fs ethA_p.Asn287fs 1 frameshift (see "Genomic_coordinates" sheet) 1 9 8 1 11 2 5201 15485 0.0021105141980046 0.00105401717787221 0.00377314786388412 0.99987085943049 0.99953357854254 0.999984360095269 0.846153846153846 0.545528944323442 0.980793328017471 0.888888888888888 0.517503485082663 0.9971908632534 0.8 0.443904537692358 0.974789273673166 23.8184964429917 3.19138024943285 1051.23813153807 0.000112139644495025 33 2233 True False 16.3752163045568 3.57157702924129 151.952602157154 0.0015358034171626 0.000663276743758576 0.0030238903173973 0.99987085943049 0.99953357854254 0.999984360095269 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance 1 2 2 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.328088282833639 Inf 0.132525557754273 60 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 16 Evidence from ALL dataset only 2) Assoc w R - Interim No change no ALL only 1 +Ethionamide ethA p.Asn287Lys ethA_p.Asn287Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 2 4 5210 15483 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.99974171886098 0.999338830952079 0.999929622742193 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.707598226178713 0 0 0.602364635616474 0 0 7.19477126316778 0.577123889343925 451 2233 False False 1.48589251439539 0.134348817103157 10.3711983427491 0 0 0.000707787682982558 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Asn298fs ethA_p.Asn298fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1223 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 569 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Asn298His ethA_p.Asn298His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Asn298Thr ethA_p.Asn298Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Asn345fs ethA_p.Asn345fs 1 frameshift (see "Genomic_coordinates" sheet) 1 7 7 0 8 2 5204 15485 0.00153491941673062 0.000662894835129567 0.00302215107874993 0.99987085943049 0.99953357854254 0.999984360095269 0.8 0.443904537692358 0.974789273673166 1 0.590383602774996 1 0.777777777777777 0.399906426283687 0.971855026522101 Inf 4.28708538200578 Inf 6.39635287108882e-05 31 2233 True False 11.902382782475 2.37390192166208 115.156672905469 0.00134331222414123 0.000540246359218131 0.00276576570582071 0.99987085943049 0.99953357854254 0.999984360095269 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance 1 2 2 0 2 2 2168 3788 0.000921658986175115 0.000111636674590768 0.0033253435449308 0.999472295514512 0.998095063429584 0.999936086148442 0.5 0.067585986488543 0.932414013511457 1 0.158113883008419 1 0.5 0.067585986488543 0.932414013511457 Inf 0.32791506008358 Inf 0.132614553342255 64 1065 False False 0 0 0 0 0 0 0 1.74723247232472 0.126540110696744 24.1244851777313 0.000921658986175115 0.000111636674590768 0.0033253435449308 0.999472295514512 0.998095063429584 0.999936086148442 18 Evidence from ALL dataset only 2) Assoc w R - Interim No change no ALL only 1 +Ethionamide ethA p.Asn345Lys ethA_p.Asn345Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 236 28 208 154 242 5058 15245 0.0295471987720644 0.0251191178491671 0.0345119225545837 0.9843739910893 0.982294837877543 0.986268182652656 0.388888888888888 0.34060018564776 0.438851455587019 0.11864406779661 0.0803040990429834 0.166892272318614 0.103703703703703 0.0700238672547069 0.146385896447102 0.405735772728655 0.262868761404759 0.604699439043578 9.54409733657321e-07 21 2233 True False 1.91802365289909 1.5527744912188 2.36338453279865 0.005505308690523 0.0036612625208883 0.00794694661348294 0.9843739910893 0.982294837877543 0.986268182652656 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 32 5 27 39 32 2131 3758 0.0179723502304147 0.0128105223520807 0.024487590166084 0.99155672823219 0.988101353650138 0.994217845032701 0.549295774647887 0.426618664628139 0.667730817676326 0.15625 0.0527505644021341 0.327878765682041 0.135135135135135 0.0453719923419939 0.287747797310572 0.326572466412916 0.0980734768155812 0.862145134413077 0.0156522873882834 27 1065 False False 0 0 0 0 0 0 0 2.14925504458 1.30758536653607 3.55466215208986 0.00234082397003745 0.000760482403102329 0.00545417971729328 0.99155672823219 0.988101353650138 0.994217845032701 632 3) Uncertain significance No change no 1 +Ethionamide ethA p.Asn379Asp ethA_p.Asn379Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 132 54 78 61 84 5151 15403 0.0117037605525709 0.00896395077347087 0.0150088939899893 0.994576096080583 0.993289177210971 0.995671443338721 0.420689655172413 0.339268856748978 0.50541871665142 0.409090909090909 0.32434723563838 0.498007024518672 0.391304347826087 0.30940643501997 0.477972706408176 2.07020294789659 1.43325506289976 2.97084513096956 7.26282656715025e-05 32 2233 True False 2.17152240434127 1.53293731557234 3.06086530988397 0.0103746397694524 0.00780308997979284 0.0135152220084392 0.994576096080583 0.993289177210971 0.995671443338721 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance 1 124 52 72 59 76 2111 3714 0.0271889400921658 0.0207604620646244 0.0349329715270582 0.979947229551451 0.97496449781135 0.984168974255809 0.437037037037037 0.351890923700679 0.525006456783136 0.419354838709677 0.33136489696077 0.511287971204164 0.40625 0.320352267729022 0.496587395209114 1.27064582346439 0.868186539721887 1.84853382687012 0.219817396167038 79 1065 False False 0 0 0 0 0 0 0 1.36581565234735 0.950975746611156 1.95330621968737 0.0240406842348589 0.0180056319187976 0.0314077737477805 0.979947229551451 0.97496449781135 0.984168974255809 11 Evidence from ALL dataset only 2) Assoc w R - Interim UP from Uncertain to AwRI yes ALL only 4 +Ethionamide ethA p.Asn379fs ethA_p.Asn379fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Asn379His ethA_p.Asn379His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1249 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Asn379Lys ethA_p.Asn379Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 12 4 8 4 8 5208 15479 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.99948343772196 0.998982421476308 0.999776959534822 0.333333333333333 0.0992460911495833 0.651124493581186 0.333333333333333 0.0992460911495833 0.651124493581186 0.333333333333333 0.0992460911495833 0.651124493581186 1.48607910906298 0.327343181309975 5.54928881094045 0.511771755536596 426 2233 False False 1.48607910906298 0.327343181309975 5.54928881094045 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.99948343772196 0.998982421476308 0.999776959534822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 3) Uncertain significance No change no 1 +Ethionamide ethA p.Asn379Ser ethA_p.Asn379Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Asn379Thr ethA_p.Asn379Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1388 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 687 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Asn388fs ethA_p.Asn388fs 1 frameshift (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 7.19247409791798 0.577090863007554 439 2233 False False 0 0 7.19247409791798 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Asn458fs ethA_p.Asn458fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1237 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 580 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Asn458Val ethA_p.Asn458Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Asp144Asn ethA_p.Asp144Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 14 5212 15473 0 0 0.000707516179821284 0.99909601601343 0.998483733164878 0.999505698211522 0 0 0.231635761650116 NA NA NA 0 0 0.231635761650116 NA NA NA NA 1282 2233 False False 0 0 0.895402656698445 0 0 0.000707516179821284 0.99909601601343 0.998483733164878 0.999505698211522 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 2170 3786 0 0 0.00169850036174098 0.998944591029023 0.997299958285064 0.999712364080324 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 609 1065 False False 0 0 0 0 0 0 0 0 0 2.6454264678615 0 0 0.00169850036174098 0.998944591029023 0.997299958285064 0.999712364080324 48 3) Uncertain significance No change no 1 +Ethionamide ethA p.Asp144Gly ethA_p.Asp144Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Asp170fs ethA_p.Asp170fs 1 frameshift (see "Genomic_coordinates" sheet) 1 4 2 2 3 2 5209 15485 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.99987085943049 0.99953357854254 0.999984360095269 0.6 0.146632799634673 0.947255049473683 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 2.97273948934536 0.215412974397121 40.9797844744598 0.264688051471407 338.5 2233 False False 4.45910923401804 0.510601005330275 53.3693689348625 0.000383803492611782 4.64837636131093e-05 0.00138573531807565 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 2 1 3 1 2167 3789 0.00138248847926267 0.000285193152965682 0.0040348522148252 0.999736147757256 0.998530795728906 0.999993319861894 0.75 0.194120449683243 0.99369053679029 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 3.49700046146746 0.181909379860788 206.107149117768 0.300981480688858 85 1065 False False 0 0 0 0 0 0 0 5.2455006922012 0.420751345257316 275.029142692281 0.000922083909635776 0.000111688152776852 0.00332687482132476 0.999736147757256 0.998530795728906 0.999993319861894 3 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Asp174Gly ethA_p.Asp174Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 6 5212 15481 0 0 0.000707516179821284 0.99961257829147 0.999156938222445 0.999857810215121 0 0 0.4592581264399 0 0 0.841886116991581 0 0 0.4592581264399 0 0 15.8192124498654 1 815 2233 False False 0 0 2.52357746319564 0 0 0.000707516179821284 0.99961257829147 0.999156938222445 0.999857810215121 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 4 2170 3786 0 0 0.00169850036174098 0.998944591029023 0.997299958285064 0.999712364080324 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 9.2950679132105 0.536796746832212 226 1065 False False 0 0 0 0 0 0 0 0 0 2.6454264678615 0 0 0.00169850036174098 0.998944591029023 0.997299958285064 0.999712364080324 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Asp196Asn ethA_p.Asp196Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1398 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 694 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 2 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Asp196fs ethA_p.Asp196fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Asp196Glu ethA_p.Asp196Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1346 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Asp219fs ethA_p.Asp219fs 1 frameshift (see "Genomic_coordinates" sheet) 1 4 4 0 4 0 5208 15487 0.00076745970836531 0.000209145270149598 0.00196382534650725 1 0.999761836368682 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 1.96217557721065 Inf 0.00401648360380072 54 2233 False False Inf 1.96217557721065 Inf 0.00076745970836531 0.000209145270149598 0.00196382534650725 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Asp219Glu ethA_p.Asp219Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Asp219Gly ethA_p.Asp219Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 5211 15485 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 115.692124084117 1 815 2233 False False 1.48579927077336 0.0251793916671698 28.5526337681963 0 0 0.000707651905360176 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 583 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Asp290fs ethA_p.Asp290fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 36 3 5176 15484 0.00690713737528779 0.00484222673175067 0.00954968462837135 0.999806289145735 0.999434000080036 0.999960050383188 0.923076923076923 0.791298078773556 0.983846699689341 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1299 2233 False False 35.8979907264296 11.3330217081364 182.18704803211 0 0 0.000712435327281524 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 624 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 29 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Asp315fs ethA_p.Asp315fs 1 frameshift (see "Genomic_coordinates" sheet) 1 13 4 9 5 9 5207 15478 0.000959324635456638 0.000311561141138009 0.0022373118395626 0.999418867437205 0.998897117312968 0.999734235852573 0.357142857142857 0.127598429859159 0.648619889384008 0.307692307692307 0.0909203945720966 0.614261661750705 0.307692307692307 0.0909203945720966 0.614261661750705 1.32112754198408 0.297156000526477 4.73591583289065 0.748893482612013 487 2233 False False 1.6514094274801 0.434525597785957 5.48973792748775 0.000767606985223565 0.000209185412851447 0.00196420198229132 0.999418867437205 0.998897117312968 0.999734235852573 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 4 7 5 7 2165 3783 0.00230414746543778 0.000748560476988087 0.00536885389822181 0.998153034300791 0.996198270365656 0.999257111678459 0.416666666666666 0.15165222980843 0.723330314317894 0.363636363636363 0.109263443819098 0.692095284988322 0.363636363636363 0.109263443819098 0.692095284988322 0.998482349059716 0.214094336173736 3.93282324627721 1 405 1065 False False 0 0 0 0 0 0 0 1.24810293632464 0.311971050368485 4.57462883500969 0.00184416781927155 0.000502695082923003 0.00471501197049527 0.998153034300791 0.996198270365656 0.999257111678459 4 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Asp336Glu ethA_p.Asp336Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1341 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Asp357del ethA_p.Asp357del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Ethionamide ethA p.Asp357Tyr ethA_p.Asp357Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 115.699581334225 1 815 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 68.0751891811639 1 405 1065 False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 0 0 0.0016992827759538 0.999736147757256 0.998530795728906 0.999993319861894 3 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Asp362fs ethA_p.Asp362fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Asp396Asn ethA_p.Asp396Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.55810577429468 Inf 0.0633939383341096 130.5 2233 False False Inf 0.55810577429468 Inf 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Asp396fs ethA_p.Asp396fs 1 frameshift (see "Genomic_coordinates" sheet) 1 7 6 1 8 1 5204 15486 0.00153491941673062 0.000662894835129567 0.00302215107874993 0.999935429715245 0.999640290494779 0.999998365223265 0.888888888888888 0.517503485082663 0.9971908632534 0.857142857142857 0.421276802956804 0.996389703138099 0.857142857142857 0.421276802956804 0.996389703138099 17.8547271329746 2.16506439401148 817.790271795153 0.00139409529106131 47 2233 False False 23.8063028439661 3.18975389486583 1050.70322780704 0.00115163147792706 0.00042274199898779 0.00250491900437395 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 6 1 6 1 2164 3789 0.00276497695852534 0.00101535276242503 0.00600840604626057 0.999736147757256 0.998530795728906 0.999993319861894 0.857142857142857 0.421276802956804 0.996389703138099 0.857142857142857 0.421276802956804 0.996389703138099 0.857142857142857 0.421276802956804 0.996389703138099 10.5055452865064 1.27283971359524 482.201010161048 0.0111776856720225 26 1065 False False 0 0 0 0 0 0 0 10.5055452865064 1.27283971359524 482.201010161048 0.00276497695852534 0.00101535276242503 0.00600840604626057 0.999736147757256 0.998530795728906 0.999993319861894 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Asp396Gly ethA_p.Asp396Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0762045661509476 Inf 0.251763455406319 213.5 2233 False False Inf 0.55810577429468 Inf 0.000191901746305891 4.8585197621771e-06 0.00106873920290263 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Asp410fs ethA_p.Asp410fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Asp410His ethA_p.Asp410His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Asp415fs ethA_p.Asp415fs 1 frameshift (see "Genomic_coordinates" sheet) 1 4 2 2 4 2 5208 15485 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.99987085943049 0.99953357854254 0.999984360095269 0.666666666666666 0.222778095503512 0.956728131707258 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 2.97331029185867 0.215454328149436 40.9879090321904 0.264626900317166 336 2233 False False 5.94662058371735 0.851897563491887 65.8224106582454 0.000383877159309021 4.64926862896582e-05 0.00138600116078139 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 3 0 2167 3790 0.00138248847926267 0.000285193152965682 0.0040348522148252 1 0.999027154404229 1 1 0.292401773821286 1 1 0.025 1 1 0.025 1 Inf 0.044824287936295 Inf 0.36388049681101 107 1065 False False 0 0 0 0 0 0 0 Inf 0.721991535026265 Inf 0.000461254612546125 1.16778875252514e-05 0.00256723823850048 1 0.999027154404229 1 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Asp415Gly ethA_p.Asp415Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1269 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 599 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 2 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Asp444Gly ethA_p.Asp444Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1310 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Asp464fs ethA_p.Asp464fs 1 frameshift (see "Genomic_coordinates" sheet) 1 11 10 1 44 5 5168 15482 0.00844205679201842 0.0061405205823405 0.0113166678517955 0.999677148576225 0.999246734667469 0.999895162977301 0.897959183673469 0.777723303717373 0.966028295016044 0.909090909090909 0.587220083011617 0.997701027786185 0.666666666666666 0.383803732541154 0.881758896633119 29.9574303405572 4.25886230742021 1291.58422632648 8.25212023988046e-06 22 2233 True False 26.3625386996904 10.471499273512 85.2480890664482 0.00193124758594051 0.000926484582364535 0.00354875583850892 0.999677148576225 0.999246734667469 0.999895162977301 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance 1 2 2 0 8 3 2162 3787 0.00368663594470046 0.00159293019145598 0.00725115327762171 0.999208443271767 0.997688494809834 0.999836732216022 0.727272727272727 0.390257440427578 0.939782265827093 1 0.158113883008419 1 0.4 0.0527449505263169 0.853367200365326 Inf 0.328738009659758 Inf 0.132192513368983 53 1065 False False 0 0 0 0 0 0 0 4.67098365710761 1.11930998215039 27.3572506446984 0.000924214417744916 0.000111946257485536 0.00333455240606835 0.999208443271767 0.997688494809834 0.999836732216022 82 Evidence from ALL dataset only 2) Assoc w R - Interim No change no ALL only 1 +Ethionamide ethA p.Asp464Gly ethA_p.Asp464Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 1 8 1 8 5211 15479 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99948343772196 0.998982421476308 0.999776959534822 0.111111111111111 0.00280913674659921 0.482496514917337 0.111111111111111 0.00280913674659921 0.482496514917337 0.111111111111111 0.00280913674659921 0.482496514917337 0.371305891383611 0.00836999418610458 2.77069344974123 0.465037164812223 421.5 2233 False False 0.371305891383611 0.00836999418610458 2.77069344974123 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99948343772196 0.998982421476308 0.999776959534822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 1 6 1 6 2169 3784 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.998416886543535 0.996557436795264 0.999418810659556 0.142857142857142 0.00361029686190058 0.578723197043195 0.142857142857142 0.00361029686190058 0.578723197043195 0.142857142857142 0.00361029686190058 0.578723197043195 0.29076379283848097 0.00632256517654589 2.39937940259791 0.434011985866556 219.5 1065 False False 0 0 0 0 0 0 0 0.29076379283848097 0.00632256517654589 2.39937940259791 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.998416886543535 0.996557436795264 0.999418810659556 11 3) Uncertain significance No change no 1 +Ethionamide ethA p.Asp46Asn ethA_p.Asp46Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Asp46fs ethA_p.Asp46fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1283 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 610 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Asp56Ala ethA_p.Asp56Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 10 6 4 9 5 5203 15482 0.00172678434382194 0.000789890217063144 0.00327543249467561 0.999677148576225 0.999246734667469 0.999895162977301 0.642857142857142 0.351380110615991 0.87240157014084 0.6 0.262378076606945 0.878447741880172 0.545454545454545 0.233793597659345 0.832511905936292 4.46338650778397 1.05790432295623 21.5074825956786 0.0203728089599593 86 2233 False False 5.35606380934076 1.6109863908159 20.3512395463489 0.00115185256287195 0.000422823176875739 0.00250539956131617 0.999677148576225 0.999246734667469 0.999895162977301 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 4 1 7 1 2163 3789 0.0032258064516129 0.00129789474017921 0.00663503149939142 0.999736147757256 0.998530795728906 0.999993319861894 0.875 0.473490329124793 0.996840276468748 0.8 0.28358206388191 0.994949236620532 0.8 0.28358206388191 0.994949236620532 7.00693481276005 0.692574973937202 344.542599267458 0.0619974319495917 42 1065 False False 0 0 0 0 0 0 0 12.26213592233 1.57306574336124 551.297896238784 0.00184586986617443 0.000503159242476888 0.00471935735058966 0.999736147757256 0.998530795728906 0.999993319861894 5 3) Uncertain significance No change no 1 +Ethionamide ethA p.Asp56Gly ethA_p.Asp56Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1224 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethionamide ethA p.Asp58Ala ethA_p.Asp58Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 1 4 5211 15483 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99974171886098 0.999338830952079 0.999929622742193 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 4.50233362814055 0.578098374390828 456 2233 False False 0.742803684513529 0.0150842538989179 7.50989306640636 0 0 0.000707651905360176 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 68.0751891811639 1 405 1065 False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 0 0 0.0016992827759538 0.999736147757256 0.998530795728906 0.999993319861894 2 3) Uncertain significance No change no 1 +Ethionamide ethA p.Asp58Asn ethA_p.Asp58Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1182 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Asp58Gly ethA_p.Asp58Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 6 1 6 1 5206 15486 0.00115118956254796 0.000422579736688136 0.00250395844332671 0.999935429715245 0.999640290494779 0.999998365223265 0.857142857142857 0.421276802956804 0.996389703138099 0.857142857142857 0.421276802956804 0.996389703138099 0.857142857142857 0.421276802956804 0.996389703138099 17.8478678447944 2.16423442406627 817.47760823406 0.00139639051828292 48 2233 False False 17.8478678447944 2.16423442406627 817.47760823406 0.00115118956254796 0.000422579736688136 0.00250395844332671 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 6 3) Uncertain significance No change no 1 +Ethionamide ethA p.Asp58His ethA_p.Asp58His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Asp77fs ethA_p.Asp77fs 1 frameshift (see "Genomic_coordinates" sheet) 1 4 1 3 1 3 5211 15484 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999806289145735 0.999434000080036 0.999960050383188 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.990468879933474 0.0188633706776044 12.3373543450537 1 815 2233 False False 0.990468879933474 0.0188633706776044 12.3373543450537 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Asp77Gly ethA_p.Asp77Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 10 2 8 4 9 5208 15478 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.999418867437205 0.998897117312968 0.999734235852573 0.307692307692307 0.0909203945720966 0.614261661750705 0.2 0.0252107263268333 0.556095462307641 0.181818181818181 0.0228311982999596 0.517755852360172 0.742991551459293 0.0768400200415031 3.72505757070201 1 815 2233 False False 1.32087386926096 0.29709911776039 4.73500643877249 0.000383877159309021 4.64926862896582e-05 0.00138600116078139 0.999418867437205 0.998897117312968 0.999734235852573 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 15 3) Uncertain significance No change no 1 +Ethionamide ethA p.Asp95fs ethA_p.Asp95fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Cys131Arg ethA_p.Cys131Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Cys131fs ethA_p.Cys131fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0762045661509476 Inf 0.251763455406319 213.5 2233 False False Inf 0.55810577429468 Inf 0.000191901746305891 4.8585197621771e-06 0.00106873920290263 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Cys131* ethA_p.Cys131* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 1 0 1 2 5211 15485 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 0.333333333333333 0.00840375865961264 0.905700675949754 1 0.025 1 0.333333333333333 0.00840375865961264 0.905700675949754 Inf 0.0761801058784979 Inf 0.251823935836111 333 2233 False False 1.48579927077336 0.0251793916671698 28.5526337681963 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Cys131Tyr ethA_p.Cys131Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 2 3 2 3 5210 15484 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999806289145735 0.999434000080036 0.999960050383188 0.4 0.0527449505263169 0.853367200365326 0.4 0.0527449505263169 0.853367200365326 0.4 0.0527449505263169 0.853367200365326 1.98131797824696 0.165426255296508 17.2953159846476 0.605417024238846 473.5 2233 False False 1.98131797824696 0.165426255296508 17.2953159846476 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 2 2 2 2 2168 3788 0.000921658986175115 0.000111636674590768 0.0033253435449308 0.999472295514512 0.998095063429584 0.999936086148442 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 1.74723247232472 0.126540110696744 24.1244851777313 0.625418981130684 278.5 1065 False False 0 0 0 0 0 0 0 1.74723247232472 0.126540110696744 24.1244851777313 0.000921658986175115 0.000111636674590768 0.0033253435449308 0.999472295514512 0.998095063429584 0.999936086148442 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Cys137Arg ethA_p.Cys137Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 28 14 14 17 14 5195 15473 0.00326170376055257 0.00190117534393765 0.00521718370320826 0.99909601601343 0.998483733164878 0.999505698211522 0.548387096774193 0.360342327160816 0.726835013996264 0.5 0.306470961532318 0.693529038467682 0.5 0.306470961532318 0.693529038467682 2.97844080846968 1.31510713137716 6.74507556561319 0.00710782421124001 62 2233 False False 3.61667812457032 1.67644553960152 7.92919546129322 0.00268765598003455 0.00147012133804355 0.00450532239370798 0.99909601601343 0.998483733164878 0.999505698211522 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 14 6 8 9 8 2161 3782 0.00414746543778801 0.00189818564765315 0.00785851894409672 0.997889182058047 0.995845105987758 0.999088271930771 0.529411764705882 0.278118300331106 0.770167312734009 0.428571428571428 0.176611089982117 0.711390599961692 0.428571428571428 0.176611089982117 0.711390599961692 1.31258676538639 0.374843438716701 4.32009957945302 0.591300307759842 275 1065 False False 0 0 0 0 0 0 0 1.96888014807959 0.673089514857081 5.87248975657271 0.00276880479926165 0.00101675932823619 0.0060167105394454 0.997889182058047 0.995845105987758 0.999088271930771 23 3) Uncertain significance No change no 1 +Ethionamide ethA p.Cys137Gly ethA_p.Cys137Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 2.97179044329303 0.0378514560716107 232.854636669753 0.440205269357083 400.5 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Cys137Phe ethA_p.Cys137Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 2.97179044329303 0.0378514560716107 232.854636669753 0.440205269357083 400.5 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Cys137Tyr ethA_p.Cys137Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 3 3 5 3 5207 15484 0.000959324635456638 0.000311561141138009 0.0022373118395626 0.999806289145735 0.999434000080036 0.999960050383188 0.625 0.244863216366551 0.914766585862746 0.5 0.118117248757025 0.881882751242974 0.5 0.118117248757025 0.881882751242974 2.97368926445169 0.398140793976683 22.2071899315177 0.172147117904867 177 2233 False False 4.95614877408616 0.963790796814113 31.9243794332185 0.000575815738963531 0.000118762793881507 0.00168184677970687 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 654 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0 0 0.00170006591133688 1 0.999027154404229 1 7 3) Uncertain significance No change no 1 +Ethionamide ethA p.Cys253Arg ethA_p.Cys253Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0761850255002428 Inf 0.251811769253067 330.5 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 2 3) Uncertain significance No change no 1 +Ethionamide ethA p.Cys253fs ethA_p.Cys253fs 1 frameshift (see "Genomic_coordinates" sheet) 1 27 13 14 20 19 5192 15468 0.00383729854182655 0.00234544915347014 0.00592020469369004 0.998773164589655 0.998084804605634 0.999261208414407 0.512820512820512 0.34780220935734 0.675819219034392 0.481481481481481 0.286672548131939 0.680503453866616 0.40625 0.236984100551743 0.593550753423523 2.7663988553819 1.19634844651512 6.34959552287141 0.0122019386187731 67 2233 False False 3.13599870245722 1.58725086140001 6.21467294638273 0.00249759846301633 0.00133051534224545 0.0042671824736382 0.998773164589655 0.998084804605634 0.999261208414407 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 4 4 6 5 2164 3785 0.00276497695852534 0.00101535276242503 0.00600840604626057 0.998680738786279 0.996923992057454 0.999571505100005 0.545454545454545 0.233793597659345 0.832511905936292 0.5 0.157012770487058 0.842987229512941 0.444444444444444 0.136995662265166 0.787991493221131 1.74907578558225 0.325416619572315 9.3997925401655 0.473114767112754 223 1065 False False 0 0 0 0 0 0 0 2.0988909426987 0.532936828719034 8.70404347780102 0.0018450184501845 0.000502927055604854 0.00471718365982354 0.998680738786279 0.996923992057454 0.999571505100005 14 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Cys253Gly ethA_p.Cys253Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0762045661509476 Inf 0.251763455406319 213.5 2233 False False Inf 0.55810577429468 Inf 0.000191901746305891 4.8585197621771e-06 0.00106873920290263 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0448036218670314 Inf 0.363987246182245 113 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0.000461041954817888 1.16725035605811e-05 0.00256605588112533 1 0.999027154404229 1 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Cys253Phe ethA_p.Cys253Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Cys253* ethA_p.Cys253* 1 stop_gained (see "Genomic_coordinates" sheet) 1 10 4 6 5 6 5207 15481 0.000959324635456638 0.000311561141138009 0.0022373118395626 0.99961257829147 0.999156938222445 0.999857810215121 0.454545454545454 0.167488094063707 0.766206402340654 0.4 0.121552258119827 0.737621923393055 0.4 0.121552258119827 0.737621923393055 1.98207541130529 0.411215077347728 8.36146685143518 0.28318010425005 346 2233 False False 2.47759426413161 0.597847637196402 9.74567065988451 0.000767606985223565 0.000209185412851447 0.00196420198229132 0.99961257829147 0.999156938222445 0.999857810215121 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Cys253Trp ethA_p.Cys253Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Cys27fs ethA_p.Cys27fs 1 frameshift (see "Genomic_coordinates" sheet) 1 4 4 0 4 0 5208 15487 0.00076745970836531 0.000209145270149598 0.00196382534650725 1 0.999761836368682 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 1.96217557721065 Inf 0.00401648360380072 54 2233 False False Inf 1.96217557721065 Inf 0.00076745970836531 0.000209145270149598 0.00196382534650725 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Cys27Tyr ethA_p.Cys27Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 5211 15485 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8263323782973 1 815 2233 False False 1.48579927077336 0.0251793916671698 28.5526337681963 0 0 0.000707651905360176 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Cys294fs ethA_p.Cys294fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Cys294Phe ethA_p.Cys294Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 2 3 3 3 5209 15484 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.999806289145735 0.999434000080036 0.999960050383188 0.5 0.118117248757025 0.881882751242974 0.4 0.0527449505263169 0.853367200365326 0.4 0.0527449505263169 0.853367200365326 1.98169834261214 0.165458013129635 17.2986384302946 0.605397411633057 472 2233 False False 2.97254751391821 0.397987980392264 22.1986618481397 0.000383803492611782 4.64837636131093e-05 0.00138573531807565 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Cys294* ethA_p.Cys294* 1 stop_gained (see "Genomic_coordinates" sheet) 1 7 5 2 5 2 5207 15485 0.000959324635456638 0.000311561141138009 0.0022373118395626 0.99987085943049 0.99953357854254 0.999984360095269 0.714285714285714 0.290420863737342 0.963307433823914 0.714285714285714 0.290420863737342 0.963307433823914 0.714285714285714 0.290420863737342 0.963307433823914 7.43470328404071 1.21658157410694 78.0025413709288 0.0132844094695818 69 2233 False False 7.43470328404071 1.21658157410694 78.0025413709288 0.000959324635456638 0.000311561141138009 0.0022373118395626 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 3 2 3 2 2167 3788 0.00138248847926267 0.000285193152965682 0.0040348522148252 0.999472295514512 0.998095063429584 0.999936086148442 0.6 0.146632799634673 0.947255049473683 0.6 0.146632799634673 0.947255049473683 0.6 0.146632799634673 0.947255049473683 2.62205814490078 0.300049946119759 31.4084209142753 0.361259490783833 101 1065 False False 0 0 0 0 0 0 0 2.62205814490078 0.300049946119759 31.4084209142753 0.00138248847926267 0.000285193152965682 0.0040348522148252 0.999472295514512 0.998095063429584 0.999936086148442 2 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Cys294Trp ethA_p.Cys294Trp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1362 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Cys294Tyr ethA_p.Cys294Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 3 4 3 4 5209 15483 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.99974171886098 0.999338830952079 0.999929622742193 0.428571428571428 0.0989882784425078 0.815948432359917 0.428571428571428 0.0989882784425078 0.815948432359917 0.428571428571428 0.0989882784425078 0.815948432359917 2.2292666538683 0.326438409930677 13.182222747906 0.378525382073867 368.5 2233 False False 2.2292666538683 0.326438409930677 13.182222747906 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 2 4 2 4 2168 3786 0.000921658986175115 0.000111636674590768 0.0033253435449308 0.998944591029023 0.997299958285064 0.999712364080324 0.333333333333333 0.0432718682927417 0.777221904496487 0.333333333333333 0.0432718682927417 0.777221904496487 0.333333333333333 0.0432718682927417 0.777221904496487 0.873154981549815 0.0789080828295634 6.09910196532408 1 405 1065 False False 0 0 0 0 0 0 0 0.873154981549815 0.0789080828295634 6.09910196532408 0.000921658986175115 0.000111636674590768 0.0033253435449308 0.998944591029023 0.997299958285064 0.999712364080324 15 3) Uncertain significance No change no 1 +Ethionamide ethA p.Cys403Arg ethA_p.Cys403Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 1 2 5211 15485 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 1.48579927077336 0.0251793916671698 28.5526337681963 1 815 2233 False False 1.48579927077336 0.0251793916671698 28.5526337681963 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 1 2 2169 3788 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999472295514512 0.998095063429584 0.999936086148442 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.87321346242508 0.0147995228023146 16.7833115850342 1 289.5 1065 False False 0 0 0 0 0 0 0 0.87321346242508 0.0147995228023146 16.7833115850342 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999472295514512 0.998095063429584 0.999936086148442 21 3) Uncertain significance No change no 1 +Ethionamide ethA p.Cys403Gly ethA_p.Cys403Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 5211 15485 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 115.692124084117 1 815 2233 False False 1.48579927077336 0.0251793916671698 28.5526337681963 0 0 0.000707651905360176 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 611 1065 False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 0 0 0.0016992827759538 0.999736147757256 0.998530795728906 0.999993319861894 3 3) Uncertain significance No change no 1 +Ethionamide ethA p.Cys403Trp ethA_p.Cys403Trp 1 missense_variant (see "Genomic_coordinates" sheet) 2 2 0 2 5 2 5207 15485 0.000959324635456638 0.000311561141138009 0.0022373118395626 0.99987085943049 0.99953357854254 0.999984360095269 0.714285714285714 0.290420863737342 0.963307433823914 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.838484545071 1 815 2233 False False 7.43470328404071 1.21658157410694 78.0025413709288 0 0 0.00070819532865061 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 570 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 10 3) Uncertain significance No change no 1 +Ethionamide ethA p.Cys403Tyr ethA_p.Cys403Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 6 0 6 0 5206 15487 0.00115118956254796 0.000422579736688136 0.00250395844332671 1 0.999761836368682 1 1 0.540741873560099 1 1 0.540741873560099 1 1 0.540741873560099 1 Inf 3.50093622554567 Inf 0.000254328292873552 37 2233 True False Inf 3.50093622554567 Inf 0.00115118956254796 0.000422579736688136 0.00250395844332671 1 0.999761836368682 1 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 Evidence from ALL dataset only 2) Assoc w R - Interim UP from Uncertain to AwRI yes ALL only 4 +Ethionamide ethA p.Gln121fs ethA_p.Gln121fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1347 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Gln121* ethA_p.Gln121* 1 stop_gained (see "Genomic_coordinates" sheet) 0 0 0 0 4 0 5208 15487 0.00076745970836531 0.000209145270149598 0.00196382534650725 1 0.999761836368682 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 1257 2233 False False Inf 1.96217557721065 Inf 0 0 0.000708059394597755 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 2167 3790 0.00138248847926267 0.000285193152965682 0.0040348522148252 1 0.999027154404229 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 592 1065 False False 0 0 0 0 0 0 0 Inf 0.721991535026265 Inf 0 0 0.00170084976888778 1 0.999027154404229 1 2 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Gln165Arg ethA_p.Gln165Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 115.669966941234 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 631 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gln165fs ethA_p.Gln165fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Gln165Glu ethA_p.Gln165Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 7.19247409791798 0.577090863007554 439 2233 False False 0 0 7.19247409791798 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gln165His ethA_p.Gln165His 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 2.97179044329303 0.0378514560716107 232.854636669753 0.440205269357083 400.5 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.74688796680497 0.0222439624669857 137.016358245527 1 405 1065 False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gln165Pro ethA_p.Gln165Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 17 2 15 3 17 5209 15470 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.998902305159165 0.998243064068552 0.999360426383401 0.15 0.0320709371854637 0.378926826545313 0.117647058823529 0.0145793168403025 0.36440916210125 0.105263157894736 0.0130121643717774 0.331376664456765 0.395981314391757 0.0439283094711738 1.7036831591313 0.269938992182173 343 2233 False False 0.524092916106738 0.0983646625128215 1.81306366578923 0.000383803492611782 4.64837636131093e-05 0.00138573531807565 0.998902305159165 0.998243064068552 0.999360426383401 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 1 9 2 11 2168 3779 0.000921658986175115 0.000111636674590768 0.0033253435449308 0.997097625329815 0.994812797611582 0.998550282198211 0.153846153846153 0.0192066719825284 0.454471055676557 0.1 0.00252857854446178 0.445016117028195 0.0833333333333333 0.00210759323186022 0.384796165150944 0.193675686756867 0.00442076931186446 1.39956069538103 0.104981396975338 50 1065 False False 0 0 0 0 0 0 0 0.316923851056692 0.0341024383487975 1.45434052103412 0.000461041954817888 1.16725035605811e-05 0.00256605588112533 0.997097625329815 0.994812797611582 0.998550282198211 7 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gln165* ethA_p.Gln165* 1 stop_gained (see "Genomic_coordinates" sheet) 1 4 3 1 4 1 5208 15486 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.999935429715245 0.999640290494779 0.999998365223265 0.8 0.28358206388191 0.994949236620532 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 8.92050691244239 0.715990228667412 467.048854197112 0.0517619162350058 104 2233 False False 11.8940092165898 1.17652678598182 583.885453446482 0.000575705238917674 0.00011874000007229 0.00168152420898675 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Gln206Glu ethA_p.Gln206Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Gln206Pro ethA_p.Gln206Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 4 0 4 0 5208 15487 0.00076745970836531 0.000209145270149598 0.00196382534650725 1 0.999761836368682 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 1.96217557721065 Inf 0.00401648360380072 54 2233 False False Inf 1.96217557721065 Inf 0.00076745970836531 0.000209145270149598 0.00196382534650725 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 2 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gln206* ethA_p.Gln206* 1 stop_gained (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 5209 15487 0.000575594781273983 0.000118717215010897 0.00168120176197813 1 0.999761836368682 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1225 2233 False False Inf 1.22809956796298 Inf 0 0 0.000707923512718415 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 571 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 4 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Gln215* ethA_p.Gln215* 1 stop_gained (see "Genomic_coordinates" sheet) 1 3 3 0 3 1 5209 15486 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.999935429715245 0.999640290494779 0.999998365223265 0.75 0.194120449683243 0.99369053679029 1 0.292401773821286 1 0.75 0.194120449683243 0.99369053679029 Inf 1.22802027016454 Inf 0.0159602983519046 78.5 2233 False False 8.91879439431752 0.715852821346612 466.959465949029 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 3 0 3 1 2167 3789 0.00138248847926267 0.000285193152965682 0.0040348522148252 0.999736147757256 0.998530795728906 0.999993319861894 0.75 0.194120449683243 0.99369053679029 1 0.292401773821286 1 0.75 0.194120449683243 0.99369053679029 Inf 0.721861899768919 Inf 0.0482477515767765 39 1065 False False 0 0 0 0 0 0 0 5.2455006922012 0.420751345257316 275.029142692281 0.00138248847926267 0.000285193152965682 0.0040348522148252 0.999736147757256 0.998530795728906 0.999993319861894 2 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Gln246Arg ethA_p.Gln246Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1315 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 641 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 3 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Gln246fs ethA_p.Gln246fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1311 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 635 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Gln246Pro ethA_p.Gln246Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.55810577429468 Inf 0.0633939383341096 130.5 2233 False False Inf 0.55810577429468 Inf 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gln246* ethA_p.Gln246* 1 stop_gained (see "Genomic_coordinates" sheet) 1 3 3 0 3 0 5209 15487 0.000575594781273983 0.000118717215010897 0.00168120176197813 1 0.999761836368682 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 1.22809956796298 Inf 0.0159579851534382 75.5 2233 False False Inf 1.22809956796298 Inf 0.000575594781273983 0.000118717215010897 0.00168120176197813 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Gln24* ethA_p.Gln24* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 115.699581334225 1 815 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 5 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Gln254Pro ethA_p.Gln254Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 14 7 7 13 9 5199 15478 0.00249424405218726 0.00132872751584936 0.0042614564942691 0.999418867437205 0.998897117312968 0.999734235852573 0.59090909090909 0.363546961729731 0.79290687700285 0.5 0.230360541448062 0.769639458551937 0.4375 0.197534140532667 0.701223100916822 2.97711098288132 0.89056181984751 9.95131299632472 0.0567561907757284 111 2233 False False 4.30027141971746 1.69927897296239 11.4046607996459 0.00134460238186707 0.000540765387055393 0.0027684201365392 0.999418867437205 0.998897117312968 0.999734235852573 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 3 2 3 4 2167 3786 0.00138248847926267 0.000285193152965682 0.0040348522148252 0.998944591029023 0.997299958285064 0.999712364080324 0.428571428571428 0.0989882784425078 0.815948432359917 0.6 0.146632799634673 0.947255049473683 0.428571428571428 0.0989882784425078 0.815948432359917 2.62067374250115 0.299891383773007 31.3918219424739 0.361356211850741 102 1065 False False 0 0 0 0 0 0 0 1.31033687125057 0.191756392649407 7.7545860694147 0.00138248847926267 0.000285193152965682 0.0040348522148252 0.998944591029023 0.997299958285064 0.999712364080324 21 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gln254* ethA_p.Gln254* 1 stop_gained (see "Genomic_coordinates" sheet) 1 7 2 5 7 7 5205 15480 0.00134305448963929 0.000540142673187124 0.00276523543039201 0.999548008006715 0.999068946905294 0.99981825708278 0.5 0.230360541448062 0.769639458551937 0.285714285714285 0.0366925661760855 0.709579136262657 0.222222222222222 0.0281449734778982 0.600093573716312 1.18962536023054 0.113223879172351 7.27059115247846 1 815 2233 False False 2.97406340057636 0.88965058489019 9.94111823940743 0.000384098329172268 4.65194748839127e-05 0.00138679930124962 0.999548008006715 0.999068946905294 0.99981825708278 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 679 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 2 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Gln269fs ethA_p.Gln269fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Gln269* ethA_p.Gln269* 1 stop_gained (see "Genomic_coordinates" sheet) 0 0 0 0 6 1 5206 15486 0.00115118956254796 0.000422579736688136 0.00250395844332671 0.999935429715245 0.999640290494779 0.999998365223265 0.857142857142857 0.421276802956804 0.996389703138099 NA NA NA 0 0 0.975 NA NA NA NA 1238 2233 False False 17.8478678447944 2.16423442406627 817.47760823406 0 0 0.000708331314907035 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 1 2166 3789 0.00184331797235023 0.00050246332413509 0.00471284227984187 0.999736147757256 0.998530795728906 0.999993319861894 0.8 0.28358206388191 0.994949236620532 NA NA NA 0 0 0.975 NA NA NA NA 584 1065 False False 0 0 0 0 0 0 0 6.9972299168975 0.691675259978101 344.066366553736 0 0 0.00170163434960586 0.999736147757256 0.998530795728906 0.999993319861894 5 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Gln271fs ethA_p.Gln271fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.55810577429468 Inf 0.0633939383341096 130.5 2233 False False Inf 0.55810577429468 Inf 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.328088282833639 Inf 0.132525557754273 60 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Gln271His ethA_p.Gln271His 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1375 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gln271Pro ethA_p.Gln271Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gln271* ethA_p.Gln271* 1 stop_gained (see "Genomic_coordinates" sheet) 1 3 3 0 3 1 5209 15486 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.999935429715245 0.999640290494779 0.999998365223265 0.75 0.194120449683243 0.99369053679029 1 0.292401773821286 1 0.75 0.194120449683243 0.99369053679029 Inf 1.22802027016454 Inf 0.0159602983519046 78.5 2233 False False 8.91879439431752 0.715852821346612 466.959465949029 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0447711586464586 Inf 0.364155059573754 211.5 1065 False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 3 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Gln291Pro ethA_p.Gln291Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1287 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gln291* ethA_p.Gln291* 1 stop_gained (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.55810577429468 Inf 0.0633939383341096 130.5 2233 False False Inf 0.55810577429468 Inf 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Gln347* ethA_p.Gln347* 1 stop_gained (see "Genomic_coordinates" sheet) 1 3 1 2 2 2 5210 15485 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.99987085943049 0.99953357854254 0.999984360095269 0.5 0.067585986488543 0.932414013511457 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 1.48608445297504 0.0251842236737227 28.558096294943 1 815 2233 False False 2.97216890595009 0.215371636513233 40.9716636776753 0.000191901746305891 4.8585197621771e-06 0.00106873920290263 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 10 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Gln359* ethA_p.Gln359* 1 stop_gained (see "Genomic_coordinates" sheet) 1 18 12 6 15 7 5197 15480 0.00287797390636991 0.0016116471700824 0.00474234467149281 0.999548008006715 0.999068946905294 0.99981825708278 0.681818181818181 0.451275572426229 0.861353478446202 0.666666666666666 0.409925238172074 0.866572597493876 0.631578947368421 0.383577923314405 0.8371141278449 5.95728304791225 2.06779851272949 19.3519725543043 0.000246154414260943 36 2233 True False 6.38280326562027 2.44776932233148 18.5107003999124 0.0023037051257439 0.00119090693486844 0.00402064783505948 0.999548008006715 0.999068946905294 0.99981825708278 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance 1 7 2 5 4 5 2166 3785 0.00184331797235023 0.00050246332413509 0.00471284227984187 0.998680738786279 0.996923992057454 0.999571505100005 0.444444444444444 0.136995662265166 0.787991493221131 0.285714285714285 0.0366925661760855 0.709579136262657 0.285714285714285 0.0366925661760855 0.709579136262657 0.698984302862419 0.0664972425599905 4.27415387810741 1 405 1065 False False 0 0 0 0 0 0 0 1.39796860572483 0.277075542102478 6.50235271774548 0.00092250922509225 0.000111739678460343 0.00332840750863215 0.998680738786279 0.996923992057454 0.999571505100005 4 Assoc w RI Evidence from ALL dataset only 2) Assoc w R - Interim No change no ALL only 1 +Ethionamide ethA p.Gln360Arg ethA_p.Gln360Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Gln360* ethA_p.Gln360* 1 stop_gained (see "Genomic_coordinates" sheet) 1 6 1 5 1 5 5211 15482 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999677148576225 0.999246734667469 0.999895162977301 0.166666666666666 0.00421074451448947 0.641234578997674 0.166666666666666 0.00421074451448947 0.641234578997674 0.166666666666666 0.00421074451448947 0.641234578997674 0.594204567261562 0.012564591702922 5.31232633024241 1 815 2233 False False 0.594204567261562 0.012564591702922 5.31232633024241 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999677148576225 0.999246734667469 0.999895162977301 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 2170 3787 0 0 0.00169850036174098 0.999208443271767 0.997688494809834 0.999836732216022 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.22663965322398 0.558201069943668 269 1065 False False 0 0 0 0 0 0 0 0 0 4.22663965322398 0 0 0.00169850036174098 0.999208443271767 0.997688494809834 0.999836732216022 2 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Gln449Pro ethA_p.Gln449Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Gln449* ethA_p.Gln449* 1 stop_gained (see "Genomic_coordinates" sheet) 1 2 0 2 1 4 5211 15483 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99974171886098 0.999338830952079 0.999929622742193 0.2 0.00505076337946806 0.716417936118089 0 0 0.841886116991581 0 0 0.602364635616474 0 0 15.8242895832639 1 815 2233 False False 0.742803684513529 0.0150842538989179 7.50989306640636 0 0 0.000707651905360176 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 2170 3787 0 0 0.00169850036174098 0.999208443271767 0.997688494809834 0.999836732216022 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 68.0079825895614 1 289.5 1065 False False 0 0 0 0 0 0 0 0 0 4.22663965322398 0 0 0.00169850036174098 0.999208443271767 0.997688494809834 0.999836732216022 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Gln73fs ethA_p.Gln73fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1250 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Gln73* ethA_p.Gln73* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Glu113Gln ethA_p.Glu113Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Glu132* ethA_p.Glu132* 1 stop_gained (see "Genomic_coordinates" sheet) 0 0 0 0 4 0 5208 15487 0.00076745970836531 0.000209145270149598 0.00196382534650725 1 0.999761836368682 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 1352 2233 False False Inf 1.96217557721065 Inf 0 0 0.000708059394597755 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 665 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0 0 0.00170006591133688 1 0.999027154404229 1 NA Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Glu155* ethA_p.Glu155* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Glu169fs ethA_p.Glu169fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Glu223_Lys224del ethA_p.Glu223_Lys224del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1376 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Ethionamide ethA p.Glu223fs ethA_p.Glu223fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1209 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 559 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Glu274fs ethA_p.Glu274fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1220 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 566 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Glu311Asp ethA_p.Glu311Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Glu311fs ethA_p.Glu311fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Glu318_Ile339del ethA_p.Glu318_Ile339del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 2.97179044329303 0.0378514560716107 232.854636669753 0.440205269357083 400.5 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Ethionamide ethA p.Glu318fs ethA_p.Glu318fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Glu332* ethA_p.Glu332* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0762045661509476 Inf 0.251763455406319 213.5 2233 False False Inf 0.55810577429468 Inf 0.000191901746305891 4.8585197621771e-06 0.00106873920290263 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 NA Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Glu36fs ethA_p.Glu36fs 1 frameshift (see "Genomic_coordinates" sheet) 2 1 0 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 115.699581334225 1 815 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 0 1 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 68.0751891811639 1 405 1065 False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 0 0 0.0016992827759538 0.999736147757256 0.998530795728906 0.999993319861894 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Glu36Gln ethA_p.Glu36Gln 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1210 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Glu36Lys ethA_p.Glu36Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Glu39fs ethA_p.Glu39fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Glu3fs ethA_p.Glu3fs 1 frameshift (see "Genomic_coordinates" sheet) 2 1 0 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 115.699581334225 1 815 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 612 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Glu3Gly ethA_p.Glu3Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1288 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 616 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Glu400fs ethA_p.Glu400fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Glu400Lys ethA_p.Glu400Lys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1232 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 575 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Glu427* ethA_p.Glu427* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Glu428fs ethA_p.Glu428fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Glu433Asp ethA_p.Glu433Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1289 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Ethionamide ethA p.Glu445fs ethA_p.Glu445fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Glu476Gln ethA_p.Glu476Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Glu476* ethA_p.Glu476* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Glu83fs ethA_p.Glu83fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.55810577429468 Inf 0.0633939383341096 130.5 2233 False False Inf 0.55810577429468 Inf 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Glu83Gly ethA_p.Glu83Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Gly11Asp ethA_p.Gly11Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0761850255002428 Inf 0.251811769253067 330.5 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gly11Cys ethA_p.Gly11Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Gly11fs ethA_p.Gly11fs 1 frameshift (see "Genomic_coordinates" sheet) 1 4 3 1 6 1 5206 15486 0.00115118956254796 0.000422579736688136 0.00250395844332671 0.999935429715245 0.999640290494779 0.999998365223265 0.857142857142857 0.421276802956804 0.996389703138099 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 8.92393392239723 0.716265201624059 467.227733386763 0.051720777882815 101.5 2233 False False 17.8478678447944 2.16423442406627 817.47760823406 0.000575926281435976 0.000118785596443588 0.00168216947420971 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 3 1 5 1 2165 3789 0.00230414746543778 0.000748560476988087 0.00536885389822181 0.999736147757256 0.998530795728906 0.999993319861894 0.833333333333333 0.358765421002325 0.99578925548551 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 5.25034642032332 0.421139938941968 275.282773879055 0.140050715166554 66 1065 False False 0 0 0 0 0 0 0 8.75057736720554 0.977928811939725 413.123713213578 0.00138376383763837 0.000285456330160625 0.00403856945153462 0.999736147757256 0.998530795728906 0.999993319861894 4 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Gly11Val ethA_p.Gly11Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 6 1 14 1 5198 15486 0.00268610897927858 0.00146927470920863 0.00450273151667691 0.999935429715245 0.999640290494779 0.999998365223265 0.933333333333333 0.680515433421696 0.998313569758647 0.857142857142857 0.421276802956804 0.996389703138099 0.857142857142857 0.421276802956804 0.996389703138099 17.8753366679492 2.16755779221257 818.729698740073 0.00138722539197677 46 2233 False False 41.7091188918814 6.34067510635841 1747.90139214907 0.00115295926210607 0.000423229534415398 0.00250780511445962 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 Assoc w RI 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Ethionamide ethA p.Gly124Asp ethA_p.Gly124Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 0 9 0 14 5212 15473 0 0 0.000707516179821284 0.99909601601343 0.998483733164878 0.999505698211522 0 0 0.231635761650116 0 0 0.336267116879942 0 0 0.231635761650116 0 0 1.50470809989614 0.123734198095116 154 2233 False False 0 0 0.895402656698445 0 0 0.000707516179821284 0.99909601601343 0.998483733164878 0.999505698211522 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 11 2170 3779 0 0 0.00169850036174098 0.997097625329815 0.994812797611582 0.998550282198211 0 0 0.284914152918154 0 0 0.409616397225003 0 0 0.284914152918154 0 0 1.20965699624319 0.0530701296990694 40 1065 False False 0 0 0 0 0 0 0 0 0 0.694759935614295 0 0 0.00169850036174098 0.997097625329815 0.994812797611582 0.998550282198211 64 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gly124Val ethA_p.Gly124Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 0 5208 15487 0.00076745970836531 0.000209145270149598 0.00196382534650725 1 0.999761836368682 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 1201 2233 False False Inf 1.96217557721065 Inf 0 0 0.000708059394597755 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 552 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gly139Ala ethA_p.Gly139Ala 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 0 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 115.699581334225 1 815 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 647 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gly139Asp ethA_p.Gly139Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 15.8222760528043 1 815 2233 False False 0 0 7.19247409791798 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 68.0259170395529 1 405 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 9 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gly139Cys ethA_p.Gly139Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Gly139Ser ethA_p.Gly139Ser 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 1 0 3 0 5209 15487 0.000575594781273983 0.000118717215010897 0.00168120176197813 1 0.999761836368682 1 1 0.292401773821286 1 1 0.025 1 1 0.025 1 Inf 0.0762191927925782 Inf 0.251727303473933 201.5 2233 False False Inf 1.22809956796298 Inf 0.00019193857965451 4.85945229729366e-06 0.00106894424519385 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 655 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gly139Val ethA_p.Gly139Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Gly13Arg ethA_p.Gly13Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1190 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gly13Glu ethA_p.Gly13Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 2 2 2 2 5210 15485 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.99987085943049 0.99953357854254 0.999984360095269 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 2.97216890595009 0.215371636513233 40.9716636776753 0.264749199588554 341 2233 False False 2.97216890595009 0.215371636513233 40.9716636776753 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 2 1 2 1 2168 3789 0.000921658986175115 0.000111636674590768 0.0033253435449308 0.999736147757256 0.998530795728906 0.999993319861894 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 3.49538745387453 0.181825522231654 206.012215468794 0.301129741671258 88 1065 False False 0 0 0 0 0 0 0 3.49538745387453 0.181825522231654 206.012215468794 0.000921658986175115 0.000111636674590768 0.0033253435449308 0.999736147757256 0.998530795728906 0.999993319861894 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gly16Asp ethA_p.Gly16Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.55810577429468 Inf 0.0633939383341096 130.5 2233 False False Inf 0.55810577429468 Inf 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 2 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gly182Ala ethA_p.Gly182Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gly182Asp ethA_p.Gly182Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 3 2 3 2 5209 15485 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.99987085943049 0.99953357854254 0.999984360095269 0.6 0.146632799634673 0.947255049473683 0.6 0.146632799634673 0.947255049473683 0.6 0.146632799634673 0.947255049473683 4.45910923401804 0.510601005330275 53.3693689348625 0.10539720630325 149 2233 False False 4.45910923401804 0.510601005330275 53.3693689348625 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gly182Cys ethA_p.Gly182Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 1 2 5211 15485 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 1.48579927077336 0.0251793916671698 28.5526337681963 1 815 2233 False False 1.48579927077336 0.0251793916671698 28.5526337681963 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gly182Ser ethA_p.Gly182Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0762045661509476 Inf 0.251763455406319 213.5 2233 False False Inf 0.55810577429468 Inf 0.000191901746305891 4.8585197621771e-06 0.00106873920290263 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gly184Asp ethA_p.Gly184Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 5210 15486 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 115.721748393509 1 815 2233 False False 5.9447216890595 0.309382652589367 349.949104522224 0 0 0.000707787682982558 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gly184del ethA_p.Gly184del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 1 0 3 0 5209 15487 0.000575594781273983 0.000118717215010897 0.00168120176197813 1 0.999761836368682 1 1 0.292401773821286 1 1 0.025 1 1 0.025 1 Inf 0.0762191927925782 Inf 0.251727303473933 201.5 2233 False False Inf 1.22809956796298 Inf 0.00019193857965451 4.85945229729366e-06 0.00106894424519385 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Ethionamide ethA p.Gly184Val ethA_p.Gly184Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Gly198Ser ethA_p.Gly198Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Gly275fs ethA_p.Gly275fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Gly275Glu ethA_p.Gly275Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1290 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gly283fs ethA_p.Gly283fs 1 frameshift (see "Genomic_coordinates" sheet) 1 6 3 3 3 3 5209 15484 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.999806289145735 0.999434000080036 0.999960050383188 0.5 0.118117248757025 0.881882751242974 0.5 0.118117248757025 0.881882751242974 0.5 0.118117248757025 0.881882751242974 2.97254751391821 0.397987980392264 22.1986618481397 0.17226231092427 179 2233 False False 2.97254751391821 0.397987980392264 22.1986618481397 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 3 3 3 3 2167 3787 0.00138248847926267 0.000285193152965682 0.0040348522148252 0.999208443271767 0.997688494809834 0.999836732216022 0.5 0.118117248757025 0.881882751242974 0.5 0.118117248757025 0.881882751242974 0.5 0.118117248757025 0.881882751242974 1.74757729580064 0.233837130446773 13.0617462404894 0.674691480942569 281.5 1065 False False 0 0 0 0 0 0 0 1.74757729580064 0.233837130446773 13.0617462404894 0.00138248847926267 0.000285193152965682 0.0040348522148252 0.999208443271767 0.997688494809834 0.999836732216022 4 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Gly299_Val310del ethA_p.Gly299_Val310del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Ethionamide ethA p.Gly299fs ethA_p.Gly299fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Gly308Trp ethA_p.Gly308Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1377 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Gly324Ala ethA_p.Gly324Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1300 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gly324Arg ethA_p.Gly324Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1325 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gly343Ala ethA_p.Gly343Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.2999762698034 0.53686319604546 244.5 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 2 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Gly343Arg ethA_p.Gly343Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gly343Glu ethA_p.Gly343Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gly343Val ethA_p.Gly343Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 3 5211 15484 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999806289145735 0.999434000080036 0.999960050383188 0.25 0.00630946320970987 0.805879550316756 0 0 0.975 0 0 0.707598226178713 0 0 115.684666832268 1 496.5 2233 False False 0.990468879933474 0.0188633706776044 12.3373543450537 0 0 0.000707651905360176 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gly350Cys ethA_p.Gly350Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gly350fs ethA_p.Gly350fs 1 frameshift (see "Genomic_coordinates" sheet) 1 12 8 4 8 4 5204 15483 0.00153491941673062 0.000662894835129567 0.00302215107874993 0.99974171886098 0.999338830952079 0.999929622742193 0.666666666666666 0.348875506418814 0.900753908850416 0.666666666666666 0.348875506418814 0.900753908850416 0.666666666666666 0.348875506418814 0.900753908850416 5.95042275172943 1.5931496781821 26.9960991395903 0.00291383876438983 50 2233 False False 5.95042275172943 1.5931496781821 26.9960991395903 0.00153491941673062 0.000662894835129567 0.00302215107874993 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 6 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Gly350Val ethA_p.Gly350Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Gly351Val ethA_p.Gly351Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gly371Cys ethA_p.Gly371Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 7 5212 15480 0 0 0.000707516179821284 0.999548008006715 0.999068946905294 0.99981825708278 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 2.52341447917258 0.347653302715337 366.5 2233 False False 0 0 2.06147084147984 0 0 0.000707516179821284 0.999548008006715 0.999068946905294 0.99981825708278 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 68.0259170395529 1 405 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 5 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gly371fs ethA_p.Gly371fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 115.669966941234 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Gly385Ala ethA_p.Gly385Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Gly385Asp ethA_p.Gly385Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 5212 15482 0 0 0.000707516179821284 0.999677148576225 0.999246734667469 0.999895162977301 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 3.24289311550326 0.33983036876334 352 2233 False False 0 0 3.24289311550326 0 0 0.000707516179821284 0.999677148576225 0.999246734667469 0.999895162977301 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 2170 3786 0 0 0.00169850036174098 0.998944591029023 0.997299958285064 0.999712364080324 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.6454264678615 0.303692649321994 95 1065 False False 0 0 0 0 0 0 0 0 0 2.6454264678615 0 0 0.00169850036174098 0.998944591029023 0.997299958285064 0.999712364080324 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Gly385fs ethA_p.Gly385fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 1 1 2 1 5210 15486 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 0.666666666666666 0.0942993240502461 0.991596241340387 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 2.97236084452975 0.0378587198701314 232.899239987393 0.440151175069926 381.5 2233 False False 5.9447216890595 0.309382652589367 349.949104522224 0.000191901746305891 4.8585197621771e-06 0.00106873920290263 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Gly413Asp ethA_p.Gly413Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 5212 15482 0 0 0.000707516179821284 0.999677148576225 0.999246734667469 0.999895162977301 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 3.24289311550326 0.33983036876334 352 2233 False False 0 0 3.24289311550326 0 0 0.000707516179821284 0.999677148576225 0.999246734667469 0.999895162977301 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gly423Arg ethA_p.Gly423Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 26 3 23 3 24 5209 15463 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.998450313165881 0.997695060668636 0.999006841908059 0.111111111111111 0.0235274543808539 0.291586924273551 0.115384615384615 0.0244580753179622 0.301540400107567 0.111111111111111 0.0235274543808539 0.291586924273551 0.387197743036717 0.074393388688772 1.28239242770739 0.171534118701328 176 2233 False False 0.37106450374352 0.0714940903093654 1.22265466989866 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.998450313165881 0.997695060668636 0.999006841908059 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gly423fs ethA_p.Gly423fs 1 frameshift (see "Genomic_coordinates" sheet) 1 4 3 1 3 1 5209 15486 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.999935429715245 0.999640290494779 0.999998365223265 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 8.91879439431752 0.715852821346612 466.959465949029 0.0517824898023508 107.5 2233 False False 8.91879439431752 0.715852821346612 466.959465949029 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.74688796680497 0.0222439624669857 137.016358245527 1 405 1065 False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Gly423Val ethA_p.Gly423Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gly42Asp ethA_p.Gly42Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 115.669966941234 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gly42Cys ethA_p.Gly42Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 115.699581334225 1 815 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 581 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Gly42fs ethA_p.Gly42fs 1 frameshift (see "Genomic_coordinates" sheet) 1 3 3 0 3 0 5209 15487 0.000575594781273983 0.000118717215010897 0.00168120176197813 1 0.999761836368682 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 1.22809956796298 Inf 0.0159579851534382 75.5 2233 False False Inf 1.22809956796298 Inf 0.000575594781273983 0.000118717215010897 0.00168120176197813 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Gly42Ser ethA_p.Gly42Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 5 5212 15482 0 0 0.000707516179821284 0.999677148576225 0.999246734667469 0.999895162977301 0 0 0.521823750104981 0 0 0.975 0 0 0.521823750104981 0 0 115.647599457306 1 815 2233 False False 0 0 3.24289311550326 0 0 0.000707516179821284 0.999677148576225 0.999246734667469 0.999895162977301 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gly42Val ethA_p.Gly42Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 0 5208 15487 0.00076745970836531 0.000209145270149598 0.00196382534650725 1 0.999761836368682 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 1291 2233 False False Inf 1.96217557721065 Inf 0 0 0.000708059394597755 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 2167 3790 0.00138248847926267 0.000285193152965682 0.0040348522148252 1 0.999027154404229 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 617 1065 False False 0 0 0 0 0 0 0 Inf 0.721991535026265 Inf 0 0 0.00170084976888778 1 0.999027154404229 1 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gly437fs ethA_p.Gly437fs 1 frameshift (see "Genomic_coordinates" sheet) 1 12 4 8 5 8 5207 15479 0.000959324635456638 0.000311561141138009 0.0022373118395626 0.99948343772196 0.998982421476308 0.999776959534822 0.384615384615384 0.13857933889016 0.684222397085936 0.333333333333333 0.0992460911495833 0.651124493581186 0.333333333333333 0.0992460911495833 0.651124493581186 1.48636450931438 0.327405984853902 5.55035264456529 0.51172556217203 425 2233 False False 1.85795563664298 0.478002631156601 6.44476231611148 0.000767606985223565 0.000209185412851447 0.00196420198229132 0.99948343772196 0.998982421476308 0.999776959534822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 3 3 3 3 2167 3787 0.00138248847926267 0.000285193152965682 0.0040348522148252 0.999208443271767 0.997688494809834 0.999836732216022 0.5 0.118117248757025 0.881882751242974 0.5 0.118117248757025 0.881882751242974 0.5 0.118117248757025 0.881882751242974 1.74757729580064 0.233837130446773 13.0617462404894 0.674691480942569 281.5 1065 False False 0 0 0 0 0 0 0 1.74757729580064 0.233837130446773 13.0617462404894 0.00138248847926267 0.000285193152965682 0.0040348522148252 0.999208443271767 0.997688494809834 0.999836732216022 5 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Gly43Ala ethA_p.Gly43Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 2.97179044329303 0.0378514560716107 232.854636669753 0.440205269357083 400.5 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gly43Arg ethA_p.Gly43Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Gly43Asp ethA_p.Gly43Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 2 3 5 3 5207 15484 0.000959324635456638 0.000311561141138009 0.0022373118395626 0.999806289145735 0.999434000080036 0.999960050383188 0.625 0.244863216366551 0.914766585862746 0.4 0.0527449505263169 0.853367200365326 0.4 0.0527449505263169 0.853367200365326 1.98245950963446 0.165521565372607 17.3052871573111 0.605358213281192 470 2233 False False 4.95614877408616 0.963790796814113 31.9243794332185 0.00038395085429065 4.65016123923256e-05 0.00138626710550647 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 2 1 3 1 2167 3789 0.00138248847926267 0.000285193152965682 0.0040348522148252 0.999736147757256 0.998530795728906 0.999993319861894 0.75 0.194120449683243 0.99369053679029 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 3.49700046146746 0.181909379860788 206.107149117768 0.300981480688858 85 1065 False False 0 0 0 0 0 0 0 5.2455006922012 0.420751345257316 275.029142692281 0.000922083909635776 0.000111688152776852 0.00332687482132476 0.999736147757256 0.998530795728906 0.999993319861894 4 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gly43Cys ethA_p.Gly43Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 115.669966941234 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 68.0259170395529 1 405 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 32 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gly43fs ethA_p.Gly43fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0762045661509476 Inf 0.251763455406319 213.5 2233 False False Inf 0.55810577429468 Inf 0.000191901746305891 4.8585197621771e-06 0.00106873920290263 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 642 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Gly43Ser ethA_p.Gly43Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 10 7 3 7 3 5205 15484 0.00134305448963929 0.000540142673187124 0.00276523543039201 0.999806289145735 0.999434000080036 0.999960050383188 0.7 0.347547149940002 0.933260488822265 0.7 0.347547149940002 0.933260488822265 0.7 0.347547149940002 0.933260488822265 6.941274415626 1.58373449676051 41.5644829671895 0.00365614686210778 51 2233 False False 6.941274415626 1.58373449676051 41.5644829671895 0.00134305448963929 0.000540142673187124 0.00276523543039201 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 2 2 2 2 2168 3788 0.000921658986175115 0.000111636674590768 0.0033253435449308 0.999472295514512 0.998095063429584 0.999936086148442 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 1.74723247232472 0.126540110696744 24.1244851777313 0.625418981130684 278.5 1065 False False 0 0 0 0 0 0 0 1.74723247232472 0.126540110696744 24.1244851777313 0.000921658986175115 0.000111636674590768 0.0033253435449308 0.999472295514512 0.998095063429584 0.999936086148442 4 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gly43Val ethA_p.Gly43Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 2 7 3 7 5209 15480 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.999548008006715 0.999068946905294 0.99981825708278 0.3 0.0667395111777345 0.652452850059997 0.222222222222222 0.0281449734778982 0.600093573716312 0.222222222222222 0.0281449734778982 0.600093573716312 0.849079889202753 0.0860371763749257 4.4612901930966 1 815 2233 False False 1.27361983380413 0.212438830534513 5.58065374082854 0.000383803492611782 4.64837636131093e-05 0.00138573531807565 0.999548008006715 0.999068946905294 0.99981825708278 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 1 6 2169 3784 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.998416886543535 0.996557436795264 0.999418810659556 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.48331967973185 0.0927400750153975 48 1065 False False 0 0 0 0 0 0 0 0.29076379283848097 0.00632256517654589 2.39937940259791 0 0 0.0016992827759538 0.998416886543535 0.996557436795264 0.999418810659556 6 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gly450Asp ethA_p.Gly450Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1258 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 593 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Gly450Cys ethA_p.Gly450Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1305 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gly450Ser ethA_p.Gly450Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 1 3 1 3 5211 15484 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999806289145735 0.999434000080036 0.999960050383188 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.990468879933474 0.0188633706776044 12.3373543450537 1 815 2233 False False 0.990468879933474 0.0188633706776044 12.3373543450537 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 5 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gly471Arg ethA_p.Gly471Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gly471Val ethA_p.Gly471Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1369 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gly477Asp ethA_p.Gly477Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1399 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 695 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gly477fs ethA_p.Gly477fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 5211 15485 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8263323782973 1 815 2233 False False 1.48579927077336 0.0251793916671698 28.5526337681963 0 0 0.000707651905360176 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 68.0751891811639 1 405 1065 False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 0 0 0.0016992827759538 0.999736147757256 0.998530795728906 0.999993319861894 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Gly488Val ethA_p.Gly488Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 115.669966941234 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gly52Arg ethA_p.Gly52Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Gly52Glu ethA_p.Gly52Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Gly63Asp ethA_p.Gly63Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 4 0 4 0 5208 15487 0.00076745970836531 0.000209145270149598 0.00196382534650725 1 0.999761836368682 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 1.96217557721065 Inf 0.00401648360380072 54 2233 False False Inf 1.96217557721065 Inf 0.00076745970836531 0.000209145270149598 0.00196382534650725 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 4 0 4 0 2166 3790 0.00184331797235023 0.00050246332413509 0.00471284227984187 1 0.999027154404229 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 1.15374841388447 Inf 0.0175424291387373 30 1065 False False 0 0 0 0 0 0 0 Inf 1.15374841388447 Inf 0.00184331797235023 0.00050246332413509 0.00471284227984187 1 0.999027154404229 1 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gly63Val ethA_p.Gly63Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1363 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gly71Arg ethA_p.Gly71Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1389 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 688 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Gly78Asp ethA_p.Gly78Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gly78Ser ethA_p.Gly78Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 5211 15485 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8263323782973 1 815 2233 False False 1.48579927077336 0.0251793916671698 28.5526337681963 0 0 0.000707651905360176 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 2169 3788 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999472295514512 0.998095063429584 0.999936086148442 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.30426475290156 0.536921227582843 261 1065 False False 0 0 0 0 0 0 0 0.87321346242508 0.0147995228023146 16.7833115850342 0 0 0.0016992827759538 0.999472295514512 0.998095063429584 0.999936086148442 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gly93Arg ethA_p.Gly93Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Gly93fs ethA_p.Gly93fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.55810577429468 Inf 0.0633939383341096 130.5 2233 False False Inf 0.55810577429468 Inf 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.His101fs ethA_p.His101fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 2.97179044329303 0.0378514560716107 232.854636669753 0.440205269357083 400.5 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.His102Pro ethA_p.His102Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 2 1 5210 15486 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 0.666666666666666 0.0942993240502461 0.991596241340387 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 2.97236084452975 0.0378587198701314 232.899239987393 0.440151175069926 381.5 2233 False False 5.9447216890595 0.309382652589367 349.949104522224 0.000191901746305891 4.8585197621771e-06 0.00106873920290263 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 560 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 7 3) Uncertain significance No change no 1 +Ethionamide ethA p.His119Arg ethA_p.His119Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.His119fs ethA_p.His119fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.His119Pro ethA_p.His119Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 2.97179044329303 0.0378514560716107 232.854636669753 0.440205269357083 400.5 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.His163Asp ethA_p.His163Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1326 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 649 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.His163fs ethA_p.His163fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0762045661509476 Inf 0.251763455406319 213.5 2233 False False Inf 0.55810577429468 Inf 0.000191901746305891 4.8585197621771e-06 0.00106873920290263 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0448036218670314 Inf 0.363987246182245 113 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0.000461041954817888 1.16725035605811e-05 0.00256605588112533 1 0.999027154404229 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.His166Pro ethA_p.His166Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 4 2 5208 15485 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.99987085943049 0.99953357854254 0.999984360095269 0.666666666666666 0.222778095503512 0.956728131707258 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8354447515761 1 815 2233 False False 5.94662058371735 0.851897563491887 65.8224106582454 0 0 0.000708059394597755 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 2168 3789 0.000921658986175115 0.000111636674590768 0.0033253435449308 0.999736147757256 0.998530795728906 0.999993319861894 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 68.1065557614001 1 405 1065 False False 0 0 0 0 0 0 0 3.49538745387453 0.181825522231654 206.012215468794 0 0 0.00170006591133688 0.999736147757256 0.998530795728906 0.999993319861894 4 3) Uncertain significance No change no 1 +Ethionamide ethA p.His201_Lys370del ethA_p.His201_Lys370del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Ethionamide ethA p.His201Pro ethA_p.His201Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 0 5208 15487 0.00076745970836531 0.000209145270149598 0.00196382534650725 1 0.999761836368682 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 1284 2233 False False Inf 1.96217557721065 Inf 0 0 0.000708059394597755 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.His22Asp ethA_p.His22Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 5212 15483 0 0 0.000707516179821284 0.99974171886098 0.999338830952079 0.999929622742193 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 4.5014696306354 0.578098957200874 462.5 2233 False False 0 0 4.5014696306354 0 0 0.000707516179821284 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.2999762698034 0.53686319604546 244.5 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 3 3) Uncertain significance No change no 1 +Ethionamide ethA p.His22fs ethA_p.His22fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 1 1 6 1 5206 15486 0.00115118956254796 0.000422579736688136 0.00250395844332671 0.999935429715245 0.999640290494779 0.999998365223265 0.857142857142857 0.421276802956804 0.996389703138099 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 2.97464464079907 0.0378878029643125 233.077824251872 0.439934719493471 375 2233 False False 17.8478678447944 2.16423442406627 817.47760823406 0.000192049164586134 4.86225205174921e-06 0.00106955984439844 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.74688796680497 0.0222439624669857 137.016358245527 1 405 1065 False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 17 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.His22Gln ethA_p.His22Gln 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1390 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 689 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.His22Pro ethA_p.His22Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 5 5212 15482 0 0 0.000707516179821284 0.999677148576225 0.999246734667469 0.999895162977301 0 0 0.521823750104981 0 0 0.975 0 0 0.521823750104981 0 0 115.647599457306 1 815 2233 False False 0 0 3.24289311550326 0 0 0.000707516179821284 0.999677148576225 0.999246734667469 0.999895162977301 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 4 2170 3786 0 0 0.00169850036174098 0.998944591029023 0.997299958285064 0.999712364080324 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 67.9900481295077 1 405 1065 False False 0 0 0 0 0 0 0 0 0 2.6454264678615 0 0 0.00169850036174098 0.998944591029023 0.997299958285064 0.999712364080324 2 3) Uncertain significance No change no 1 +Ethionamide ethA p.His22Tyr ethA_p.His22Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1191 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.His281Arg ethA_p.His281Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 2 6 3 7 5209 15480 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.999548008006715 0.999068946905294 0.99981825708278 0.3 0.0667395111777345 0.652452850059997 0.25 0.0318540262499442 0.650855794412824 0.222222222222222 0.0281449734778982 0.600093573716312 0.990593204069879 0.0977384812097934 5.54141449584685 1 815 2233 False False 1.27361983380413 0.212438830534513 5.58065374082854 0.000383803492611782 4.64837636131093e-05 0.00138573531807565 0.999548008006715 0.999068946905294 0.99981825708278 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 2169 3788 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999472295514512 0.998095063429584 0.999936086148442 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.30426475290156 0.536921227582843 261 1065 False False 0 0 0 0 0 0 0 0.87321346242508 0.0147995228023146 16.7833115850342 0 0 0.0016992827759538 0.999472295514512 0.998095063429584 0.999936086148442 11 3) Uncertain significance No change no 1 +Ethionamide ethA p.His281fs ethA_p.His281fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 4 0 5208 15487 0.00076745970836531 0.000209145270149598 0.00196382534650725 1 0.999761836368682 1 1 0.397635364383525 1 1 0.025 1 1 0.025 1 Inf 0.0762338250501108 Inf 0.251691148047931 196 2233 False False Inf 1.96217557721065 Inf 0.000191975427145325 4.860385190457e-06 0.00106914936617667 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.His281Gln ethA_p.His281Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1391 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 690 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.His281Pro ethA_p.His281Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 14 5 9 333 134 4879 15353 0.0638910207214121 0.0574013689833719 0.0708741036392447 0.991347581842836 0.989760585570998 0.992745619987871 0.71306209850107 0.669705451155534 0.753696167969704 0.357142857142857 0.127598429859159 0.648619889384008 0.0359712230215827 0.0117811206243228 0.081946981150088 1.74819521304456 0.460006579018216 5.81073306986759 0.347339366782394 358 2233 False False 7.81991202014114 6.36150025177907 9.65322771910068 0.00102375102375102 0.000332490078888561 0.00238746278359708 0.991347581842836 0.989760585570998 0.992745619987871 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 2 5 313 113 1857 3677 0.144239631336405 0.129715036051757 0.15973205387283 0.97018469656992 0.964262448961215 0.975366214557107 0.734741784037558 0.690107138862903 0.776081376634716 0.285714285714285 0.0366925661760855 0.709579136262657 0.017391304347826 0.00211315082226153 0.0614123325587228 0.792030156165858 0.0753473586173142 4.84355684596609 1 289.5 1065 False False 0 0 0 0 0 0 0 5.48463360353791 4.3743591804356 6.9108759745825 0.00107584722969338 0.000130316656293823 0.00388087270699022 0.97018469656992 0.964262448961215 0.975366214557107 61 3) Uncertain significance No change no 1 +Ethionamide ethA p.His285fs ethA_p.His285fs 1 frameshift (see "Genomic_coordinates" sheet) 1 3 1 2 2 2 5210 15485 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.99987085943049 0.99953357854254 0.999984360095269 0.5 0.067585986488543 0.932414013511457 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 1.48608445297504 0.0251842236737227 28.558096294943 1 815 2233 False False 2.97216890595009 0.215371636513233 40.9716636776753 0.000191901746305891 4.8585197621771e-06 0.00106873920290263 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.His285Pro ethA_p.His285Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 7.19247409791798 0.577090863007554 439 2233 False False 0 0 7.19247409791798 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Ethionamide ethA p.His307Gln ethA_p.His307Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.His307Pro ethA_p.His307Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.His4Arg ethA_p.His4Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.His4Asn ethA_p.His4Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.His4fs ethA_p.His4fs 1 frameshift (see "Genomic_coordinates" sheet) 1 4 1 3 1 3 5211 15484 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999806289145735 0.999434000080036 0.999960050383188 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.990468879933474 0.0188633706776044 12.3373543450537 1 815 2233 False False 0.990468879933474 0.0188633706776044 12.3373543450537 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 1 2 2169 3788 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999472295514512 0.998095063429584 0.999936086148442 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.87321346242508 0.0147995228023146 16.7833115850342 1 289.5 1065 False False 0 0 0 0 0 0 0 0.87321346242508 0.0147995228023146 16.7833115850342 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999472295514512 0.998095063429584 0.999936086148442 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.His97fs ethA_p.His97fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1382 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Ile105Leu ethA_p.Ile105Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 1 4 2 7 5210 15480 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999548008006715 0.999068946905294 0.99981825708278 0.222222222222222 0.0281449734778982 0.600093573716312 0.2 0.00505076337946806 0.716417936118089 0.125 0.0031597235312519 0.526509670875206 0.742802303262955 0.0150842253106995 7.50987952913126 1 815 2233 False False 0.848916918014806 0.0860206666092397 4.46043370684753 0.000191901746305891 4.8585197621771e-06 0.00106873920290263 0.999548008006715 0.999068946905294 0.99981825708278 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 3 2169 3787 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999208443271767 0.997688494809834 0.999836732216022 0.25 0.00630946320970987 0.805879550316756 0.5 0.012579117093425 0.987420882906574 0.25 0.00630946320970987 0.805879550316756 1.74596588289534 0.0222322210010108 136.944136500668 1 289.5 1065 False False 0 0 0 0 0 0 0 0.581988627631781 0.0110856993615618 7.25404417491437 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999208443271767 0.997688494809834 0.999836732216022 14 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ile120Asn ethA_p.Ile120Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ile120Val ethA_p.Ile120Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ile161fs ethA_p.Ile161fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1192 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 548 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Ile161Ser ethA_p.Ile161Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1205 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ile161Thr ethA_p.Ile161Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1353 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 666 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Ile161Val ethA_p.Ile161Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 2 7 5210 15480 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999548008006715 0.999068946905294 0.99981825708278 0.222222222222222 0.0281449734778982 0.600093573716312 0 0 0.4592581264399 0 0 0.409616397225003 0 0 2.52438334624971 0.3476398216979 359.5 2233 False False 0.848916918014806 0.0860206666092397 4.46043370684753 0 0 0.000707787682982558 0.999548008006715 0.999068946905294 0.99981825708278 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ile162Ser ethA_p.Ile162Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Ile178fs ethA_p.Ile178fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1332 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Ile178Ser ethA_p.Ile178Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Ile178Val ethA_p.Ile178Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ile181fs ethA_p.Ile181fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1312 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 636 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Ile181Ser ethA_p.Ile181Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1316 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ile212Met ethA_p.Ile212Met 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1193 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 549 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ile221fs ethA_p.Ile221fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1342 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 661 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0 0 0.00170006591133688 1 0.999027154404229 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Ile305Ser ethA_p.Ile305Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 2 2 2 2 5210 15485 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.99987085943049 0.99953357854254 0.999984360095269 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 2.97216890595009 0.215371636513233 40.9716636776753 0.264749199588554 341 2233 False False 2.97216890595009 0.215371636513233 40.9716636776753 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 2 2 2 2 2168 3788 0.000921658986175115 0.000111636674590768 0.0033253435449308 0.999472295514512 0.998095063429584 0.999936086148442 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 1.74723247232472 0.126540110696744 24.1244851777313 0.625418981130684 278.5 1065 False False 0 0 0 0 0 0 0 1.74723247232472 0.126540110696744 24.1244851777313 0.000921658986175115 0.000111636674590768 0.0033253435449308 0.999472295514512 0.998095063429584 0.999936086148442 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ile325Asn ethA_p.Ile325Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Ile325fs ethA_p.Ile325fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Ile337fs ethA_p.Ile337fs 1 frameshift (see "Genomic_coordinates" sheet) 1 14 7 7 7 8 5205 15479 0.00134305448963929 0.000540142673187124 0.00276523543039201 0.99948343772196 0.998982421476308 0.999776959534822 0.466666666666666 0.212666729519307 0.734138652722603 0.5 0.230360541448062 0.769639458551937 0.466666666666666 0.212666729519307 0.734138652722603 2.97387127761767 0.889593101993551 9.94047587891312 0.0568544370400023 112 2233 False False 2.60213736791546 0.802808501288404 8.21585665432776 0.00134305448963929 0.000540142673187124 0.00276523543039201 0.99948343772196 0.998982421476308 0.999776959534822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 6 4 6 5 2164 3785 0.00276497695852534 0.00101535276242503 0.00600840604626057 0.998680738786279 0.996923992057454 0.999571505100005 0.545454545454545 0.233793597659345 0.832511905936292 0.6 0.262378076606945 0.878447741880172 0.545454545454545 0.233793597659345 0.832511905936292 2.62361367837338 0.621278008834602 12.6549445025339 0.18493524743691 76 1065 False False 0 0 0 0 0 0 0 2.0988909426987 0.532936828719034 8.70404347780102 0.00276497695852534 0.00101535276242503 0.00600840604626057 0.998680738786279 0.996923992057454 0.999571505100005 46 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Ile337Val ethA_p.Ile337Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 10 5212 15477 0 0 0.000707516179821284 0.99935429715245 0.998812851129914 0.999690318343011 0 0 0.30849710781876 NA NA NA 0 0 0.30849710781876 NA NA NA NA 1383 2233 False False 0 0 1.32532562767373 0 0 0.000707516179821284 0.99935429715245 0.998812851129914 0.999690318343011 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 59 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ile338Leu ethA_p.Ile338Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Ile338Met ethA_p.Ile338Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ile338Ser ethA_p.Ile338Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 1 5209 15486 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.999935429715245 0.999640290494779 0.999998365223265 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 115.743923948461 1 496.5 2233 False False 8.91879439431752 0.715852821346612 466.959465949029 0 0 0.000707923512718415 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 2167 3790 0.00138248847926267 0.000285193152965682 0.0040348522148252 1 0.999027154404229 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 637 1065 False False 0 0 0 0 0 0 0 Inf 0.721991535026265 Inf 0 0 0.00170084976888778 1 0.999027154404229 1 3 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ile339del ethA_p.Ile339del 1 inframe_deletion (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1211 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Ethionamide ethA p.Ile339dup ethA_p.Ile339dup 1 inframe_insertion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Ethionamide ethA p.Ile339fs ethA_p.Ile339fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Ile339Ser ethA_p.Ile339Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ile34Met ethA_p.Ile34Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ile34Ser ethA_p.Ile34Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.55810577429468 Inf 0.0633939383341096 130.5 2233 False False Inf 0.55810577429468 Inf 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ile34Thr ethA_p.Ile34Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 3 6 4 6 5208 15481 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.99961257829147 0.999156938222445 0.999857810215121 0.4 0.121552258119827 0.737621923393055 0.333333333333333 0.0748546314196918 0.700704943791459 0.333333333333333 0.0748546314196918 0.700704943791459 1.48627112135176 0.240419595354088 6.96203682466896 0.700329882546658 481.5 2233 False False 1.98169482846902 0.411136149006771 8.35986151202817 0.000575705238917674 0.00011874000007229 0.00168152420898675 0.99961257829147 0.999156938222445 0.999857810215121 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 3 5 4 5 2166 3785 0.00184331797235023 0.00050246332413509 0.00471284227984187 0.998680738786279 0.996923992057454 0.999571505100005 0.444444444444444 0.136995662265166 0.787991493221131 0.375 0.0852334141372535 0.755136783633448 0.375 0.0852334141372535 0.755136783633448 1.04847645429362 0.162654665023482 5.39459153396798 1 405 1065 False False 0 0 0 0 0 0 0 1.39796860572483 0.277075542102478 6.50235271774548 0.00138312586445366 0.000285324680875951 0.00403670997741914 0.998680738786279 0.996923992057454 0.999571505100005 11 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ile356Thr ethA_p.Ile356Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1226 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ile377Lys ethA_p.Ile377Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ile473Ser ethA_p.Ile473Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0762045661509476 Inf 0.251763455406319 213.5 2233 False False Inf 0.55810577429468 Inf 0.000191901746305891 4.8585197621771e-06 0.00106873920290263 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 561 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ile75Thr ethA_p.Ile75Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Ile81_His102del ethA_p.Ile81_His102del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Ethionamide ethA p.Ile81fs ethA_p.Ile81fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0761850255002428 Inf 0.251811769253067 330.5 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Ile81Thr ethA_p.Ile81Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1206 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ile94fs ethA_p.Ile94fs 1 frameshift (see "Genomic_coordinates" sheet) 1 3 1 2 2 2 5210 15485 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.99987085943049 0.99953357854254 0.999984360095269 0.5 0.067585986488543 0.932414013511457 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 1.48608445297504 0.0251842236737227 28.558096294943 1 815 2233 False False 2.97216890595009 0.215371636513233 40.9716636776753 0.000191901746305891 4.8585197621771e-06 0.00106873920290263 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 3 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Ile94Ser ethA_p.Ile94Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 3 5211 15484 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999806289145735 0.999434000080036 0.999960050383188 0.25 0.00630946320970987 0.805879550316756 0 0 0.975 0 0 0.707598226178713 0 0 115.684666832268 1 496.5 2233 False False 0.990468879933474 0.0188633706776044 12.3373543450537 0 0 0.000707651905360176 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ile98Val ethA_p.Ile98Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ile9fs ethA_p.Ile9fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 3 0 5209 15487 0.000575594781273983 0.000118717215010897 0.00168120176197813 1 0.999761836368682 1 1 0.292401773821286 1 1 0.025 1 1 0.025 1 Inf 0.0762191927925782 Inf 0.251727303473933 201.5 2233 False False Inf 1.22809956796298 Inf 0.00019193857965451 4.85945229729366e-06 0.00106894424519385 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 643 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 5 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Ile9Ser ethA_p.Ile9Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ile9Thr ethA_p.Ile9Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 1 6 5211 15481 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99961257829147 0.999156938222445 0.999857810215121 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.602364635616474 0 0 0.4592581264399 0 0 4.50175211023012 0.578098760128075 457 2233 False False 0.495138489093584 0.0107661625367428 4.08269117192464 0 0 0.000707651905360176 0.99961257829147 0.999156938222445 0.999857810215121 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 662 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 8 3) Uncertain significance No change no 1 +Ethionamide ethA p.Leu126fs ethA_p.Leu126fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1317 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Leu126Phe ethA_p.Leu126Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1221 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 567 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Leu129_Val312del ethA_p.Leu129_Val312del 1 inframe_deletion (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1233 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Ethionamide ethA p.Leu129Arg ethA_p.Leu129Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 1 5209 15486 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.999935429715245 0.999640290494779 0.999998365223265 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 1400 2233 False False 8.91879439431752 0.715852821346612 466.959465949029 0 0 0.000707923512718415 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 1 2167 3789 0.00138248847926267 0.000285193152965682 0.0040348522148252 0.999736147757256 0.998530795728906 0.999993319861894 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 696 1065 False False 0 0 0 0 0 0 0 5.2455006922012 0.420751345257316 275.029142692281 0 0 0.00170084976888778 0.999736147757256 0.998530795728906 0.999993319861894 23 3) Uncertain significance No change no 1 +Ethionamide ethA p.Leu129fs ethA_p.Leu129fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 3 0 5209 15487 0.000575594781273983 0.000118717215010897 0.00168120176197813 1 0.999761836368682 1 1 0.292401773821286 1 1 0.025 1 1 0.025 1 Inf 0.0762191927925782 Inf 0.251727303473933 201.5 2233 False False Inf 1.22809956796298 Inf 0.00019193857965451 4.85945229729366e-06 0.00106894424519385 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Leu129Pro ethA_p.Leu129Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 115.669966941234 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 568 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Leu134Arg ethA_p.Leu134Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 2 1 3 4 5209 15483 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.99974171886098 0.999338830952079 0.999929622742193 0.428571428571428 0.0989882784425078 0.815948432359917 0.666666666666666 0.0942993240502461 0.991596241340387 0.333333333333333 0.0432718682927417 0.777221904496487 5.94471107698214 0.309382082702407 349.94848557136 0.15826623526567 172 2233 False False 2.2292666538683 0.326438409930677 13.182222747906 0.000383803492611782 4.64837636131093e-05 0.00138573531807565 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 3 2169 3787 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999208443271767 0.997688494809834 0.999836732216022 0.25 0.00630946320970987 0.805879550316756 1 0.025 1 0.25 0.00630946320970987 0.805879550316756 Inf 0.0447475262497974 Inf 0.364277320799059 213 1065 False False 0 0 0 0 0 0 0 0.581988627631781 0.0110856993615618 7.25404417491437 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999208443271767 0.997688494809834 0.999836732216022 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Leu134His ethA_p.Leu134His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1392 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Leu134Pro ethA_p.Leu134Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 3 4 3 4 5209 15483 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.99974171886098 0.999338830952079 0.999929622742193 0.428571428571428 0.0989882784425078 0.815948432359917 0.428571428571428 0.0989882784425078 0.815948432359917 0.428571428571428 0.0989882784425078 0.815948432359917 2.2292666538683 0.326438409930677 13.182222747906 0.378525382073867 368.5 2233 False False 2.2292666538683 0.326438409930677 13.182222747906 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 2 1 2 1 2168 3789 0.000921658986175115 0.000111636674590768 0.0033253435449308 0.999736147757256 0.998530795728906 0.999993319861894 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 3.49538745387453 0.181825522231654 206.012215468794 0.301129741671258 88 1065 False False 0 0 0 0 0 0 0 3.49538745387453 0.181825522231654 206.012215468794 0.000921658986175115 0.000111636674590768 0.0033253435449308 0.999736147757256 0.998530795728906 0.999993319861894 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Leu136Arg ethA_p.Leu136Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 1 3 3 4 5209 15483 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.99974171886098 0.999338830952079 0.999929622742193 0.428571428571428 0.0989882784425078 0.815948432359917 0.25 0.00630946320970987 0.805879550316756 0.2 0.00505076337946806 0.716417936118089 0.990785179497024 0.0188693932469836 12.3412943360447 1 815 2233 False False 2.2292666538683 0.326438409930677 13.182222747906 0.00019193857965451 4.85945229729366e-06 0.00106894424519385 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 2 3 2168 3787 0.000921658986175115 0.000111636674590768 0.0033253435449308 0.999208443271767 0.997688494809834 0.999836732216022 0.4 0.0527449505263169 0.853367200365326 0.333333333333333 0.00840375865961264 0.905700675949754 0.25 0.00630946320970987 0.805879550316756 0.873385608856088 0.0148024361228706 16.7866230331159 1 405 1065 False False 0 0 0 0 0 0 0 1.16451414514145 0.0971616864304866 10.1720933334353 0.000461041954817888 1.16725035605811e-05 0.00256605588112533 0.999208443271767 0.997688494809834 0.999836732216022 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Leu171Phe ethA_p.Leu171Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Leu190fs ethA_p.Leu190fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 2 0 4 0 5208 15487 0.00076745970836531 0.000209145270149598 0.00196382534650725 1 0.999761836368682 1 1 0.397635364383525 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.558320038919588 Inf 0.0633575340063644 117 2233 False False Inf 1.96217557721065 Inf 0.000383877159309021 4.64926862896582e-05 0.00138600116078139 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0448036218670314 Inf 0.363987246182245 113 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0.000461041954817888 1.16725035605811e-05 0.00256605588112533 1 0.999027154404229 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Leu190Phe ethA_p.Leu190Phe 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 5209 15487 0.000575594781273983 0.000118717215010897 0.00168120176197813 1 0.999761836368682 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1239 2233 False False Inf 1.22809956796298 Inf 0 0 0.000707923512718415 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 585 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0 0 0.00170006591133688 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Leu190Pro ethA_p.Leu190Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 3 2 5209 15485 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.99987085943049 0.99953357854254 0.999984360095269 0.6 0.146632799634673 0.947255049473683 0.5 0.012579117093425 0.987420882906574 0.333333333333333 0.00840375865961264 0.905700675949754 2.97273948934536 0.037863541272799 232.928849565579 0.440115276140959 378 2233 False False 4.45910923401804 0.510601005330275 53.3693689348625 0.00019193857965451 4.85945229729366e-06 0.00106894424519385 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 68.0751891811639 1 405 1065 False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 0 0 0.0016992827759538 0.999736147757256 0.998530795728906 0.999993319861894 2 3) Uncertain significance No change no 1 +Ethionamide ethA p.Leu194_Ala195delinsPro ethA_p.Leu194_Ala195delinsPro 1 inframe_deletion (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1348 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Ethionamide ethA p.Leu194Arg ethA_p.Leu194Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1259 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Leu194fs ethA_p.Leu194fs 1 frameshift (see "Genomic_coordinates" sheet) 1 4 1 3 1 3 5211 15484 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999806289145735 0.999434000080036 0.999960050383188 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.990468879933474 0.0188633706776044 12.3373543450537 1 815 2233 False False 0.990468879933474 0.0188633706776044 12.3373543450537 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Leu194Pro ethA_p.Leu194Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 4 1 4 1 5208 15486 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.999935429715245 0.999640290494779 0.999998365223265 0.8 0.28358206388191 0.994949236620532 0.8 0.28358206388191 0.994949236620532 0.8 0.28358206388191 0.994949236620532 11.8940092165898 1.17652678598182 583.885453446482 0.0160393454684176 81 2233 False False 11.8940092165898 1.17652678598182 583.885453446482 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 2 3) Uncertain significance No change no 1 +Ethionamide ethA p.Leu205Arg ethA_p.Leu205Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Leu205Pro ethA_p.Leu205Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 4 1 5 1 5207 15486 0.000959324635456638 0.000311561141138009 0.0022373118395626 0.999935429715245 0.999640290494779 0.999998365223265 0.833333333333333 0.358765421002325 0.99578925548551 0.8 0.28358206388191 0.994949236620532 0.8 0.28358206388191 0.994949236620532 11.8962934511234 1.17675257102566 583.997182717025 0.0160307143263555 80 2233 False False 14.8703668139043 1.66317699294464 700.725693531947 0.000767606985223565 0.000209185412851447 0.00196420198229132 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 3 0 2167 3790 0.00138248847926267 0.000285193152965682 0.0040348522148252 1 0.999027154404229 1 1 0.292401773821286 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.328239646677015 Inf 0.132447859973667 55 1065 False False 0 0 0 0 0 0 0 Inf 0.721991535026265 Inf 0.000922083909635776 0.000111688152776852 0.00332687482132476 1 0.999027154404229 1 8 3) Uncertain significance No change no 1 +Ethionamide ethA p.Leu225Arg ethA_p.Leu225Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Leu225fs ethA_p.Leu225fs 1 frameshift (see "Genomic_coordinates" sheet) 1 18 11 7 19 8 5193 15479 0.00364543361473522 0.00219617244689937 0.00568696754173622 0.99948343772196 0.998982421476308 0.999776959534822 0.703703703703703 0.498186333629998 0.86247344605942 0.611111111111111 0.357451205893062 0.827014145210248 0.578947368421052 0.334997844011735 0.797478561022837 4.68402519875656 1.65704157525777 14.2584525485238 0.00130698065269925 44 2233 False False 7.07926535721163 2.95671781577642 18.6972348236755 0.00211375864719446 0.00105563819917541 0.00377894340304199 0.99948343772196 0.998982421476308 0.999776959534822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 4 2 5 2 2165 3788 0.00230414746543778 0.000748560476988087 0.00536885389822181 0.999472295514512 0.998095063429584 0.999936086148442 0.714285714285714 0.290420863737342 0.963307433823914 0.666666666666666 0.222778095503512 0.956728131707258 0.666666666666666 0.222778095503512 0.956728131707258 3.49930715935334 0.500933462528285 38.7059147441551 0.199189788825566 77 1065 False False 0 0 0 0 0 0 0 4.37413394919168 0.715190220301017 45.9579406529699 0.00184416781927155 0.000502695082923003 0.00471501197049527 0.999472295514512 0.998095063429584 0.999936086148442 11 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Leu225His ethA_p.Leu225His 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Leu225Pro ethA_p.Leu225Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 1 3 1 3 5211 15484 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999806289145735 0.999434000080036 0.999960050383188 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.990468879933474 0.0188633706776044 12.3373543450537 1 815 2233 False False 0.990468879933474 0.0188633706776044 12.3373543450537 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 5 3) Uncertain significance No change no 1 +Ethionamide ethA p.Leu229Arg ethA_p.Leu229Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 5210 15486 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 115.721748393509 1 815 2233 False False 5.9447216890595 0.309382652589367 349.949104522224 0 0 0.000707787682982558 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Leu23Arg ethA_p.Leu23Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 5 4 6 4 5206 15483 0.00115118956254796 0.000422579736688136 0.00250395844332671 0.99974171886098 0.999338830952079 0.999929622742193 0.6 0.262378076606945 0.878447741880172 0.555555555555555 0.212008506778868 0.863004337734833 0.555555555555555 0.212008506778868 0.863004337734833 3.71758547829427 0.799771140861034 18.7372166478936 0.0502753130806579 98 2233 False False 4.46110257395313 1.0573629606249 21.4964665374794 0.000959508731529456 0.000311620943906444 0.0022377409088434 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 4 3 4 3 2166 3787 0.00184331797235023 0.00050246332413509 0.00471284227984187 0.999208443271767 0.997688494809834 0.999836732216022 0.571428571428571 0.184051567640083 0.901011721557492 0.571428571428571 0.184051567640083 0.901011721557492 0.571428571428571 0.184051567640083 0.901011721557492 2.33117882425361 0.393926468212413 15.9294208698161 0.265558373453665 81 1065 False False 0 0 0 0 0 0 0 2.33117882425361 0.393926468212413 15.9294208698161 0.00184331797235023 0.00050246332413509 0.00471284227984187 0.999208443271767 0.997688494809834 0.999836732216022 20 3) Uncertain significance No change no 1 +Ethionamide ethA p.Leu23Pro ethA_p.Leu23Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1370 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Leu244Pro ethA_p.Leu244Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 18 6 12 6 12 5206 15475 0.00115118956254796 0.000422579736688136 0.00250395844332671 0.99922515658294 0.998646896080726 0.999599565042795 0.333333333333333 0.133427402506123 0.590074761827925 0.333333333333333 0.133427402506123 0.590074761827925 0.333333333333333 0.133427402506123 0.590074761827925 1.4862658470995 0.457426437531843 4.28135803811662 0.420266359622341 370 2233 False False 1.4862658470995 0.457426437531843 4.28135803811662 0.00115118956254796 0.000422579736688136 0.00250395844332671 0.99922515658294 0.998646896080726 0.999599565042795 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 5 3 5 3 2165 3787 0.00230414746543778 0.000748560476988087 0.00536885389822181 0.999208443271767 0.997688494809834 0.999836732216022 0.625 0.244863216366551 0.914766585862746 0.625 0.244863216366551 0.914766585862746 0.625 0.244863216366551 0.914766585862746 2.9153194765204 0.566479632607818 18.786985063018 0.149650627159879 69 1065 False False 0 0 0 0 0 0 0 2.9153194765204 0.566479632607818 18.786985063018 0.00230414746543778 0.000748560476988087 0.00536885389822181 0.999208443271767 0.997688494809834 0.999836732216022 6 3) Uncertain significance No change no 1 +Ethionamide ethA p.Leu265fs ethA_p.Leu265fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1202 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Leu272Pro ethA_p.Leu272Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 7 5212 15480 0 0 0.000707516179821284 0.999548008006715 0.999068946905294 0.99981825708278 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 2.06147084147984 0.203408797729811 184 2233 False False 0 0 2.06147084147984 0 0 0.000707516179821284 0.999548008006715 0.999068946905294 0.99981825708278 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 2170 3784 0 0 0.00169850036174098 0.998416886543535 0.996557436795264 0.999418810659556 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.48263576179074 0.0927092577734561 46 1065 False False 0 0 0 0 0 0 0 0 0 1.48263576179074 0 0 0.00169850036174098 0.998416886543535 0.996557436795264 0.999418810659556 14 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Leu293* ethA_p.Leu293* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Leu295fs ethA_p.Leu295fs 1 frameshift (see "Genomic_coordinates" sheet) 1 22 12 10 19 10 5193 15477 0.00364543361473522 0.00219617244689937 0.00568696754173622 0.99935429715245 0.998812851129914 0.999690318343011 0.655172413793103 0.456694272332056 0.820616350764888 0.545454545454545 0.322104754553171 0.756138134076983 0.545454545454545 0.322104754553171 0.756138134076983 3.57642980935875 1.41509048979052 9.24540769472052 0.00471913020399083 57 2233 False False 5.66268053148469 2.50308443814593 13.6380892234497 0.00230547550432276 0.00119182255964202 0.00402373500808918 0.99935429715245 0.998812851129914 0.999690318343011 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 16 12 4 18 4 2152 3786 0.00829493087557603 0.00492329693497667 0.0130779973003701 0.998944591029023 0.997299958285064 0.999712364080324 0.818181818181818 0.597154216922128 0.948132700687563 0.75 0.476229180103872 0.927337961747117 0.75 0.476229180103872 0.927337961747117 5.27788104089219 1.59662101809523 22.4740613496629 0.00259739229955389 21 1065 False False 0 0 0 0 0 0 0 7.91682156133829 2.60241032225693 32.2071082758754 0.0055452865064695 0.0028685148598587 0.00966644454882703 0.998944591029023 0.997299958285064 0.999712364080324 15 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Leu295Trp ethA_p.Leu295Trp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1275 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 602 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0 0 0.00170006591133688 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Leu301Arg ethA_p.Leu301Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Leu301Pro ethA_p.Leu301Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 5212 15481 0 0 0.000707516179821284 0.99961257829147 0.999156938222445 0.999857810215121 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 2.52357746319564 0.347651033317578 363.5 2233 False False 0 0 2.52357746319564 0 0 0.000707516179821284 0.99961257829147 0.999156938222445 0.999857810215121 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 2170 3784 0 0 0.00169850036174098 0.998416886543535 0.996557436795264 0.999418810659556 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.48263576179074 0.0927092577734561 46 1065 False False 0 0 0 0 0 0 0 0 0 1.48263576179074 0 0 0.00169850036174098 0.998416886543535 0.996557436795264 0.999418810659556 2 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Leu327fs ethA_p.Leu327fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1327 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 650 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Leu333Pro ethA_p.Leu333Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Leu344del ethA_p.Leu344del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1333 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Ethionamide ethA p.Leu344fs ethA_p.Leu344fs 1 frameshift (see "Genomic_coordinates" sheet) 1 8 4 4 4 4 5208 15483 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.99974171886098 0.999338830952079 0.999929622742193 0.5 0.157012770487058 0.842987229512941 0.5 0.157012770487058 0.842987229512941 0.5 0.157012770487058 0.842987229512941 2.9729262672811 0.553517542355507 15.9639231757182 0.116279505712791 152.5 2233 False False 2.9729262672811 0.553517542355507 15.9639231757182 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 4 4 4 4 2166 3786 0.00184331797235023 0.00050246332413509 0.00471284227984187 0.998944591029023 0.997299958285064 0.999712364080324 0.5 0.157012770487058 0.842987229512941 0.5 0.157012770487058 0.842987229512941 0.5 0.157012770487058 0.842987229512941 1.74792243767313 0.325202474825824 9.39358812111239 0.473246274200722 224 1065 False False 0 0 0 0 0 0 0 1.74792243767313 0.325202474825824 9.39358812111239 0.00184331797235023 0.00050246332413509 0.00471284227984187 0.998944591029023 0.997299958285064 0.999712364080324 8 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Leu344Phe ethA_p.Leu344Phe 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1378 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Leu344Ser ethA_p.Leu344Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Leu348Ile ethA_p.Leu348Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1260 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 594 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 16 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Leu348Phe ethA_p.Leu348Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 21 2 19 2 20 5210 15467 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.9987085943049 0.998006229813624 0.999211003011252 0.0909090909090909 0.0112055860241509 0.291612741553933 0.0952380952380952 0.0117493178844458 0.303774406913924 0.0909090909090909 0.0112055860241509 0.291612741553933 0.312496211738559 0.0352853830463064 1.29605041304982 0.130315666335801 156 2233 False False 0.296871401151631 0.0336265355960959 1.22281729530781 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.9987085943049 0.998006229813624 0.999211003011252 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.74688796680497 0.0222439624669857 137.016358245527 1 405 1065 False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 47 3) Uncertain significance No change no 1 +Ethionamide ethA p.Leu348Pro ethA_p.Leu348Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Leu35Arg ethA_p.Leu35Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 11 9 2 12 2 5200 15485 0.00230237912509593 0.00119022113901414 0.0040183355622907 0.99987085943049 0.99953357854254 0.999984360095269 0.857142857142857 0.571870839090301 0.982205484516808 0.818181818181818 0.482244147639827 0.97716880170004 0.818181818181818 0.482244147639827 0.97716880170004 13.4004807692307 2.77204814753665 127.644808316207 0.000132898754836977 35 2233 True False 17.8673076923076 3.97510822169961 164.217375899422 0.00172777884430792 0.000790345305400887 0.00327731743761889 0.99987085943049 0.99953357854254 0.999984360095269 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance 1 1 0 1 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 68.0751891811639 1 405 1065 False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 0 0 0.0016992827759538 0.999736147757256 0.998530795728906 0.999993319861894 3 Evidence from ALL dataset only 2) Assoc w R - Interim UP from Uncertain to AwRI yes ALL only 4 +Ethionamide ethA p.Leu35Pro ethA_p.Leu35Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 115.699581334225 1 815 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 682 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Leu35Val ethA_p.Leu35Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 1 3 1 4 5211 15483 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99974171886098 0.999338830952079 0.999929622742193 0.2 0.00505076337946806 0.716417936118089 0.25 0.00630946320970987 0.805879550316756 0.2 0.00505076337946806 0.716417936118089 0.990404912684705 0.018862152417974 12.3365577722115 1 815 2233 False False 0.742803684513529 0.0150842538989179 7.50989306640636 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 68.0259170395529 1 405 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Leu374Arg ethA_p.Leu374Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 2 1 2 1 5210 15486 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 5.9447216890595 0.309382652589367 349.949104522224 0.158265844695452 166.5 2233 False False 5.9447216890595 0.309382652589367 349.949104522224 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Leu374His ethA_p.Leu374His 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 1 2 5211 15485 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 1.48579927077336 0.0251793916671698 28.5526337681963 1 815 2233 False False 1.48579927077336 0.0251793916671698 28.5526337681963 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Leu374Phe ethA_p.Leu374Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Leu393Arg ethA_p.Leu393Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1323 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Leu393fs ethA_p.Leu393fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Leu393Pro ethA_p.Leu393Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Leu393Val ethA_p.Leu393Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1234 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Leu397Arg ethA_p.Leu397Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 2 1 5210 15486 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 0.666666666666666 0.0942993240502461 0.991596241340387 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 2.97236084452975 0.0378587198701314 232.899239987393 0.440151175069926 381.5 2233 False False 5.9447216890595 0.309382652589367 349.949104522224 0.000191901746305891 4.8585197621771e-06 0.00106873920290263 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Leu397Pro ethA_p.Leu397Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 3 3 3 3 5209 15484 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.999806289145735 0.999434000080036 0.999960050383188 0.5 0.118117248757025 0.881882751242974 0.5 0.118117248757025 0.881882751242974 0.5 0.118117248757025 0.881882751242974 2.97254751391821 0.397987980392264 22.1986618481397 0.17226231092427 179 2233 False False 2.97254751391821 0.397987980392264 22.1986618481397 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.328088282833639 Inf 0.132525557754273 60 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Leu405fs ethA_p.Leu405fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1313 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Leu405Ser ethA_p.Leu405Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Leu406fs ethA_p.Leu406fs 1 frameshift (see "Genomic_coordinates" sheet) 1 10 0 10 0 11 5212 15476 0 0 0.000707516179821284 0.999289726867695 0.998729481387772 0.999645382583254 0 0 0.284914152918154 0 0 0.30849710781876 0 0 0.284914152918154 0 0 1.3252400094018 0.0753437291315039 146 2233 False False 0 0 1.18361858819336 0 0 0.000707516179821284 0.999289726867695 0.998729481387772 0.999645382583254 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Leu406Ser ethA_p.Leu406Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Leu440fs ethA_p.Leu440fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1212 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Leu440Pro ethA_p.Leu440Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 13 1 12 2 14 5210 15473 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.99909601601343 0.998483733164878 0.999505698211522 0.125 0.0155136038154138 0.383476236849263 0.0769230769230769 0.00194562849734675 0.360297435267877 0.0666666666666666 0.0016864302413527 0.319484566578303 0.247488803582853 0.00579212010409808 1.67344625900696 0.206279202119853 186 2233 False False 0.424266520427748 0.0467880762232892 1.84825736980451 0.000191901746305891 4.8585197621771e-06 0.00106873920290263 0.99909601601343 0.998483733164878 0.999505698211522 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 1 10 2 11 2168 3779 0.000921658986175115 0.000111636674590768 0.0033253435449308 0.997097625329815 0.994812797611582 0.998550282198211 0.153846153846153 0.0192066719825284 0.454471055676557 0.0909090909090909 0.00229897221381426 0.412779916988382 0.0833333333333333 0.00210759323186022 0.384796165150944 0.17430811808118 0.0040187909704969 1.22695430067427 0.0658714607704344 44 1065 False False 0 0 0 0 0 0 0 0.316923851056692 0.0341024383487975 1.45434052103412 0.000461041954817888 1.16725035605811e-05 0.00256605588112533 0.997097625329815 0.994812797611582 0.998550282198211 23 3) Uncertain significance No change no 1 +Ethionamide ethA p.Leu443Pro ethA_p.Leu443Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1306 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 632 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Leu478Arg ethA_p.Leu478Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 1 4 5211 15483 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99974171886098 0.999338830952079 0.999929622742193 0.2 0.00505076337946806 0.716417936118089 0.333333333333333 0.00840375865961264 0.905700675949754 0.2 0.00505076337946806 0.716417936118089 1.48560736902705 0.0251761395480941 28.5489586172875 1 815 2233 False False 0.742803684513529 0.0150842538989179 7.50989306640636 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 6 3) Uncertain significance No change no 1 +Ethionamide ethA p.Leu478fs ethA_p.Leu478fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 4 1 5208 15486 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.999935429715245 0.999640290494779 0.999998365223265 0.8 0.28358206388191 0.994949236620532 0 0 0.975 0 0 0.975 0 0 115.766108003968 1 815 2233 False False 11.8940092165898 1.17652678598182 583.885453446482 0 0 0.000708059394597755 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Leu47fs ethA_p.Leu47fs 1 frameshift (see "Genomic_coordinates" sheet) 1 13 4 9 4 11 5208 15476 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.999289726867695 0.998729481387772 0.999645382583254 0.266666666666666 0.0778715462910436 0.551003241036971 0.307692307692307 0.0909203945720966 0.614261661750705 0.266666666666666 0.0778715462910436 0.551003241036971 1.32070319167093 0.297060829071733 4.7343948881131 0.748915535499733 488 2233 False False 1.08057533863985 0.250833454915806 3.64851950723252 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.999289726867695 0.998729481387772 0.999645382583254 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 1 6 1 6 2169 3784 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.998416886543535 0.996557436795264 0.999418810659556 0.142857142857142 0.00361029686190058 0.578723197043195 0.142857142857142 0.00361029686190058 0.578723197043195 0.142857142857142 0.00361029686190058 0.578723197043195 0.29076379283848097 0.00632256517654589 2.39937940259791 0.434011985866556 219.5 1065 False False 0 0 0 0 0 0 0 0.29076379283848097 0.00632256517654589 2.39937940259791 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.998416886543535 0.996557436795264 0.999418810659556 19 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Leu47Ser ethA_p.Leu47Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1379 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethionamide ethA p.Leu5Phe ethA_p.Leu5Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 16 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Leu62Arg ethA_p.Leu62Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 2 1 2 1 5210 15486 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 5.9447216890595 0.309382652589367 349.949104522224 0.158265844695452 166.5 2233 False False 5.9447216890595 0.309382652589367 349.949104522224 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 3 3) Uncertain significance No change no 1 +Ethionamide ethA p.Leu62Gln ethA_p.Leu62Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1285 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Leu62Ile ethA_p.Leu62Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Leu62Pro ethA_p.Leu62Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 2 2 4 2 5208 15485 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.99987085943049 0.99953357854254 0.999984360095269 0.666666666666666 0.222778095503512 0.956728131707258 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 2.97331029185867 0.215454328149436 40.9879090321904 0.264626900317166 336 2233 False False 5.94662058371735 0.851897563491887 65.8224106582454 0.000383877159309021 4.64926862896582e-05 0.00138600116078139 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 2 1 3 1 2167 3789 0.00138248847926267 0.000285193152965682 0.0040348522148252 0.999736147757256 0.998530795728906 0.999993319861894 0.75 0.194120449683243 0.99369053679029 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 3.49700046146746 0.181909379860788 206.107149117768 0.300981480688858 85 1065 False False 0 0 0 0 0 0 0 5.2455006922012 0.420751345257316 275.029142692281 0.000922083909635776 0.000111688152776852 0.00332687482132476 0.999736147757256 0.998530795728906 0.999993319861894 5 3) Uncertain significance No change no 1 +Ethionamide ethA p.Leu82Arg ethA_p.Leu82Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethionamide ethA p.Leu82fs ethA_p.Leu82fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1401 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Leu82Pro ethA_p.Leu82Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.55810577429468 Inf 0.0633939383341096 130.5 2233 False False Inf 0.55810577429468 Inf 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.328088282833639 Inf 0.132525557754273 60 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Lys103fs ethA_p.Lys103fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Lys103* ethA_p.Lys103* 1 stop_gained (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1183 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 544 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Lys200Arg ethA_p.Lys200Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Lys200fs ethA_p.Lys200fs 1 frameshift (see "Genomic_coordinates" sheet) 1 13 7 6 7 6 5205 15481 0.00134305448963929 0.000540142673187124 0.00276523543039201 0.99961257829147 0.999156938222445 0.999857810215121 0.538461538461538 0.251345482270303 0.807767558198712 0.538461538461538 0.251345482270303 0.807767558198712 0.538461538461538 0.251345482270303 0.807767558198712 3.46996477745757 0.997956294931619 12.5063013275122 0.0252043934385871 87 2233 False False 3.46996477745757 0.997956294931619 12.5063013275122 0.00134305448963929 0.000540142673187124 0.00276523543039201 0.99961257829147 0.999156938222445 0.999857810215121 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 58 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Lys224dup ethA_p.Lys224dup 1 inframe_insertion (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1292 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Ethionamide ethA p.Lys224fs ethA_p.Lys224fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Lys241fs ethA_p.Lys241fs 1 frameshift (see "Genomic_coordinates" sheet) 1 3 3 0 4 0 5208 15487 0.00076745970836531 0.000209145270149598 0.00196382534650725 1 0.999761836368682 1 1 0.397635364383525 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 1.22833528740534 Inf 0.0159511116874657 73 2233 False False Inf 1.96217557721065 Inf 0.000575705238917674 0.00011874000007229 0.00168152420898675 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 3 0 3 0 2167 3790 0.00138248847926267 0.000285193152965682 0.0040348522148252 1 0.999027154404229 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.721991535026265 Inf 0.0482234657957814 36.5 1065 False False 0 0 0 0 0 0 0 Inf 0.721991535026265 Inf 0.00138248847926267 0.000285193152965682 0.0040348522148252 1 0.999027154404229 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Lys241* ethA_p.Lys241* 1 stop_gained (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1402 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 697 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Lys241Thr ethA_p.Lys241Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1261 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 595 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Lys280fs ethA_p.Lys280fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1276 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Lys280Thr ethA_p.Lys280Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1194 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 550 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Lys30_Ser31insArg ethA_p.Lys30_Ser31insArg 1 inframe_insertion (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1262 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Ethionamide ethA p.Lys309fs ethA_p.Lys309fs 1 frameshift (see "Genomic_coordinates" sheet) 1 11 2 9 3 9 5209 15478 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.999418867437205 0.998897117312968 0.999734235852573 0.25 0.0548606445279927 0.571858461878189 0.181818181818181 0.0228311982999596 0.517755852360172 0.181818181818181 0.0228311982999596 0.517755852360172 0.660310146967854 0.0694045170374882 3.19147192415476 0.74124295185085 483 2233 False False 0.990465220451782 0.172404197298185 3.97087964508817 0.000383803492611782 4.64837636131093e-05 0.00138573531807565 0.999418867437205 0.998897117312968 0.999734235852573 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 1 5 2169 3785 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.998680738786279 0.996923992057454 0.999571505100005 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.90632744124825 0.166099171218194 72 1065 False False 0 0 0 0 0 0 0 0.349008759797141 0.00737988563135068 3.12211888418912 0 0 0.0016992827759538 0.998680738786279 0.996923992057454 0.999571505100005 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Lys30fs ethA_p.Lys30fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 2 4 5210 15483 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.99974171886098 0.999338830952079 0.999929622742193 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.841886116991581 0 0 0.602364635616474 0 0 15.8273254809733 1 815 2233 False False 1.48589251439539 0.134348817103157 10.3711983427491 0 0 0.000707787682982558 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 2 3 2168 3787 0.000921658986175115 0.000111636674590768 0.0033253435449308 0.999208443271767 0.997688494809834 0.999836732216022 0.4 0.0527449505263169 0.853367200365326 0 0 0.841886116991581 0 0 0.707598226178713 0 0 9.30610075020441 0.536946053838044 263 1065 False False 0 0 0 0 0 0 0 1.16451414514145 0.0971616864304866 10.1720933334353 0 0 0.00170006591133688 0.999208443271767 0.997688494809834 0.999836732216022 4 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Lys370_Tyr382del ethA_p.Lys370_Tyr382del 1 inframe_deletion (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1307 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 633 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 3 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Ethionamide ethA p.Lys370fs ethA_p.Lys370fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Lys370Thr ethA_p.Lys370Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 1 5208 15486 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.999935429715245 0.999640290494779 0.999998365223265 0.8 0.28358206388191 0.994949236620532 NA NA NA 0 0 0.975 NA NA NA NA 1364 2233 False False 11.8940092165898 1.17652678598182 583.885453446482 0 0 0.000708059394597755 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 1 2168 3789 0.000921658986175115 0.000111636674590768 0.0033253435449308 0.999736147757256 0.998530795728906 0.999993319861894 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 672 1065 False False 0 0 0 0 0 0 0 3.49538745387453 0.181825522231654 206.012215468794 0 0 0.00170006591133688 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Lys37fs ethA_p.Lys37fs 1 frameshift (see "Genomic_coordinates" sheet) 1 164 81 83 109 86 5103 15401 0.0209132770529547 0.0172026537620285 0.0251730159325593 0.994446955511073 0.993146513852202 0.995555952347471 0.558974358974359 0.486277193818225 0.629850919691046 0.49390243902439 0.415063058126454 0.572966142950105 0.48502994011976 0.407104939006484 0.563495644778132 2.94530502964237 2.1376815476174 4.05613061170687 2.00483587971582e-11 12 2233 True False 3.82517579718268 2.85121555709434 5.14509262642731 0.015625 0.0124273596545798 0.0193835004311837 0.994446955511073 0.993146513852202 0.995555952347471 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 115 63 52 74 54 2096 3736 0.0341013824884792 0.0268698491766268 0.0426237138920096 0.98575197889182 0.98144986861271 0.989278806412183 0.578125 0.48769500835487 0.664856367001277 0.547826086956521 0.452306066857751 0.640822898359715 0.538461538461538 0.443889844833043 0.631039463516385 2.15949794480328 1.46561600375195 3.19306959595109 5.06018993172877e-05 12 1065 True False 0 0 0 0 0 0 0 2.44260672886627 1.68901594733536 3.5506195021337 0.0291801760074108 0.0224941046881773 0.037181245271874 0.98575197889182 0.98144986861271 0.989278806412183 153 1) Assoc w R UP from AwRI to AwR yes 4 +Ethionamide ethA p.Lys394* ethA_p.Lys394* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Lys394Thr ethA_p.Lys394Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1195 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Lys448fs ethA_p.Lys448fs 1 frameshift (see "Genomic_coordinates" sheet) 1 8 4 4 10 4 5202 15483 0.00191864927091327 0.000920438305261622 0.00352562450313611 0.99974171886098 0.999338830952079 0.999929622742193 0.714285714285714 0.418964742816338 0.916110681692872 0.5 0.157012770487058 0.842987229512941 0.5 0.157012770487058 0.842987229512941 2.97635524798154 0.554154826951405 15.9823351511901 0.115975811544495 151 2233 False False 7.44088811995386 2.14483161232111 32.5398124629895 0.000768344218209758 0.000209386357728754 0.00196608733030437 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 3 2 8 2 2162 3788 0.00368663594470046 0.00159293019145598 0.00725115327762171 0.999472295514512 0.998095063429584 0.999936086148442 0.8 0.443904537692358 0.974789273673166 0.6 0.146632799634673 0.947255049473683 0.6 0.146632799634673 0.947255049473683 2.62812210915818 0.300743799004306 31.4811660896613 0.360838123260447 99 1065 False False 0 0 0 0 0 0 0 7.00832562442183 1.39645399072679 67.8805502516635 0.00138568129330254 0.000285852007943472 0.00404415816669477 0.999472295514512 0.998095063429584 0.999936086148442 8 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Lys482fs ethA_p.Lys482fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Lys86* ethA_p.Lys86* 1 stop_gained (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 2.97179044329303 0.0378514560716107 232.854636669753 0.440205269357083 400.5 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 1 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Met1? ethA_p.Met1? 1 start_lost (see "Genomic_coordinates" sheet) 1 99 52 47 58 49 5154 15438 0.011128165771297 0.00846062632445397 0.0143622661098765 0.996836056047007 0.995819230294592 0.997658407981462 0.542056074766355 0.44296753602698 0.638757475466829 0.525252525252525 0.422397277030751 0.626557001069105 0.514851485148514 0.413283474733546 0.615525825783827 3.31399697817848 2.18745506623078 5.03181511246096 6.94289922542626e-09 16 2233 True False 3.54550854101827 2.3784863408498 5.30319567293476 0.00998847483672685 0.0074686152784459 0.0130781592475126 0.996836056047007 0.995819230294592 0.997658407981462 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 36 25 11 25 12 2145 3778 0.0115207373271889 0.00746910666734498 0.0169601879423384 0.996833773087071 0.994475777251357 0.998362927167916 0.675675675675675 0.502146716486603 0.819861351947943 0.694444444444444 0.51892936999992 0.836526015371506 0.675675675675675 0.502146716486603 0.819861351947943 4.00296673023945 1.89498938018282 9.02971302587527 7.33550129558328e-05 13 1065 True False 0 0 0 0 0 0 0 3.66938616938617 1.77179621140887 8.03102192851833 0.0115207373271889 0.00746910666734498 0.0169601879423384 0.996833773087071 0.994475777251357 0.998362927167916 46 1) Assoc w R UP from AwRI to AwR yes 4 +Ethionamide ethA p.Met204Arg ethA_p.Met204Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Met204Thr ethA_p.Met204Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 1 3 1 3 5211 15484 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999806289145735 0.999434000080036 0.999960050383188 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.990468879933474 0.0188633706776044 12.3373543450537 1 815 2233 False False 0.990468879933474 0.0188633706776044 12.3373543450537 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 2 3) Uncertain significance No change no 1 +Ethionamide ethA p.Met204Val ethA_p.Met204Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 9 1 5203 15486 0.00172678434382194 0.000789890217063144 0.00327543249467561 0.999935429715245 0.999640290494779 0.999998365223265 0.9 0.554983882971804 0.997471421455538 NA NA NA 0 0 0.975 NA NA NA NA 1318 2233 False False 26.787238131847 3.71007179833019 1167.16985789294 0 0 0.000708739587198625 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 1 2167 3789 0.00138248847926267 0.000285193152965682 0.0040348522148252 0.999736147757256 0.998530795728906 0.999993319861894 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 644 1065 False False 0 0 0 0 0 0 0 5.2455006922012 0.420751345257316 275.029142692281 0 0 0.00170084976888778 0.999736147757256 0.998530795728906 0.999993319861894 4 3) Uncertain significance No change no 1 +Ethionamide ethA p.Met233_Thr236delinsIle ethA_p.Met233_Thr236delinsIle 1 inframe_deletion (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1380 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 680 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Ethionamide ethA p.Met233fs ethA_p.Met233fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1328 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 651 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Met233Ile ethA_p.Met233Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Met233Val ethA_p.Met233Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Met260fs ethA_p.Met260fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 2 0 6 0 5206 15487 0.00115118956254796 0.000422579736688136 0.00250395844332671 1 0.999761836368682 1 1 0.540741873560099 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.558534468140888 Inf 0.0633211331008263 115 2233 False False Inf 3.50093622554567 Inf 0.000384024577572964 4.65105419230854e-05 0.00138653315230962 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.328088282833639 Inf 0.132525557754273 60 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 3 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Met260Ile ethA_p.Met260Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 8 5212 15479 0 0 0.000707516179821284 0.99948343772196 0.998982421476308 0.999776959534822 0 0 0.369416647552819 0 0 0.409616397225003 0 0 0.369416647552819 0 0 2.061337672877 0.203405245147688 183 2233 False False 0 0 1.74050626415467 0 0 0.000707516179821284 0.99948343772196 0.998982421476308 0.999776959534822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 576 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 10 3) Uncertain significance No change no 1 +Ethionamide ethA p.Met263_Phe320delinsIle ethA_p.Met263_Phe320delinsIle 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Ethionamide ethA p.Met263Thr ethA_p.Met263Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1263 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Met372Arg ethA_p.Met372Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 115.699581334225 1 815 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethionamide ethA p.Met372fs ethA_p.Met372fs 1 frameshift (see "Genomic_coordinates" sheet) 1 3 3 0 3 0 5209 15487 0.000575594781273983 0.000118717215010897 0.00168120176197813 1 0.999761836368682 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 1.22809956796298 Inf 0.0159579851534382 75.5 2233 False False Inf 1.22809956796298 Inf 0.000575594781273983 0.000118717215010897 0.00168120176197813 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Met372Thr ethA_p.Met372Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1207 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 555 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 2 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Met373Ile ethA_p.Met373Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 2.97179044329303 0.0378514560716107 232.854636669753 0.440205269357083 400.5 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.74688796680497 0.0222439624669857 137.016358245527 1 405 1065 False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Met373Thr ethA_p.Met373Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Ethionamide ethA p.Met373Val ethA_p.Met373Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Met380Ile ethA_p.Met380Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1251 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 590 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Met409Arg ethA_p.Met409Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1301 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 625 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 3 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Met409Ile ethA_p.Met409Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Met409Thr ethA_p.Met409Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 1 3 1 4 5211 15483 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99974171886098 0.999338830952079 0.999929622742193 0.2 0.00505076337946806 0.716417936118089 0.25 0.00630946320970987 0.805879550316756 0.2 0.00505076337946806 0.716417936118089 0.990404912684705 0.018862152417974 12.3365577722115 1 815 2233 False False 0.742803684513529 0.0150842538989179 7.50989306640636 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 2 2169 3788 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999472295514512 0.998095063429584 0.999936086148442 0.333333333333333 0.00840375865961264 0.905700675949754 0.5 0.012579117093425 0.987420882906574 0.333333333333333 0.00840375865961264 0.905700675949754 1.74642692485016 0.0222380917340097 136.980247384435 1 405 1065 False False 0 0 0 0 0 0 0 0.87321346242508 0.0147995228023146 16.7833115850342 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999472295514512 0.998095063429584 0.999936086148442 4 3) Uncertain significance No change no 1 +Ethionamide ethA p.Met41Arg ethA_p.Met41Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 3 1 3 1 5209 15486 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.999935429715245 0.999640290494779 0.999998365223265 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 8.91879439431752 0.715852821346612 466.959465949029 0.0517824898023508 107.5 2233 False False 8.91879439431752 0.715852821346612 466.959465949029 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Ethionamide ethA p.Met41Ile ethA_p.Met41Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 7.19247409791798 0.577090863007554 439 2233 False False 0 0 7.19247409791798 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 2170 3787 0 0 0.00169850036174098 0.999208443271767 0.997688494809834 0.999836732216022 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.22663965322398 0.558201069943668 269 1065 False False 0 0 0 0 0 0 0 0 0 4.22663965322398 0 0 0.00169850036174098 0.999208443271767 0.997688494809834 0.999836732216022 2 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Met432fs ethA_p.Met432fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1349 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 663 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Met59Arg ethA_p.Met59Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 3 0 5209 15487 0.000575594781273983 0.000118717215010897 0.00168120176197813 1 0.999761836368682 1 1 0.292401773821286 1 1 0.025 1 1 0.025 1 Inf 0.0762191927925782 Inf 0.251727303473933 201.5 2233 False False Inf 1.22809956796298 Inf 0.00019193857965451 4.85945229729366e-06 0.00106894424519385 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 11 3) Uncertain significance No change no 1 +Ethionamide ethA p.Met59fs ethA_p.Met59fs 1 frameshift (see "Genomic_coordinates" sheet) 1 6 4 2 4 2 5208 15485 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.99987085943049 0.99953357854254 0.999984360095269 0.666666666666666 0.222778095503512 0.956728131707258 0.666666666666666 0.222778095503512 0.956728131707258 0.666666666666666 0.222778095503512 0.956728131707258 5.94662058371735 0.851897563491887 65.8224106582454 0.0385321016822305 93.5 2233 False False 5.94662058371735 0.851897563491887 65.8224106582454 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Met59Thr ethA_p.Met59Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 7.19247409791798 0.577090863007554 439 2233 False False 0 0 7.19247409791798 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Phe100fs ethA_p.Phe100fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 2 3 5210 15484 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999806289145735 0.999434000080036 0.999960050383188 0.4 0.0527449505263169 0.853367200365326 0 0 0.841886116991581 0 0 0.707598226178713 0 0 15.8283470748561 1 815 2233 False False 1.98131797824696 0.165426255296508 17.2953159846476 0 0 0.000707787682982558 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 68.0751891811639 1 405 1065 False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 0 0 0.0016992827759538 0.999736147757256 0.998530795728906 0.999993319861894 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Phe133Ser ethA_p.Phe133Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1227 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Phe151fs ethA_p.Phe151fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Phe151Leu ethA_p.Phe151Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Phe157Ser ethA_p.Phe157Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 5209 15487 0.000575594781273983 0.000118717215010897 0.00168120176197813 1 0.999761836368682 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1371 2233 False False Inf 1.22809956796298 Inf 0 0 0.000707923512718415 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 2167 3790 0.00138248847926267 0.000285193152965682 0.0040348522148252 1 0.999027154404229 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 676 1065 False False 0 0 0 0 0 0 0 Inf 0.721991535026265 Inf 0 0 0.00170084976888778 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Phe264Leu ethA_p.Phe264Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1235 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 577 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 2 3) Uncertain significance No change no 1 +Ethionamide ethA p.Phe264Ser ethA_p.Phe264Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 3 3) Uncertain significance No change no 1 +Ethionamide ethA p.Phe282fs ethA_p.Phe282fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1264 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Phe282Leu ethA_p.Phe282Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 3 3) Uncertain significance No change no 1 +Ethionamide ethA p.Phe282Ser ethA_p.Phe282Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Phe282Val ethA_p.Phe282Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 10 4 6 11 8 5201 15479 0.0021105141980046 0.00105401717787221 0.00377314786388412 0.99948343772196 0.998982421476308 0.999776959534822 0.578947368421052 0.334997844011735 0.797478561022837 0.4 0.121552258119827 0.737621923393055 0.333333333333333 0.0992460911495833 0.651124493581186 1.98410562071396 0.411636095171937 8.37003090586663 0.282868729749508 345 2233 False False 4.09221784272255 1.49818651069046 11.7251029499822 0.000768491834774255 0.00020942659304007 0.0019664648343086 0.99948343772196 0.998982421476308 0.999776959534822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 68.0751891811639 1 405 1065 False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 0 0 0.0016992827759538 0.999736147757256 0.998530795728906 0.999993319861894 5 3) Uncertain significance No change no 1 +Ethionamide ethA p.Phe302Leu ethA_p.Phe302Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1196 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Phe302Ser ethA_p.Phe302Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 2.97179044329303 0.0378514560716107 232.854636669753 0.440205269357083 400.5 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 2 3) Uncertain significance No change no 1 +Ethionamide ethA p.Phe302Val ethA_p.Phe302Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 1 6 5211 15481 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99961257829147 0.999156938222445 0.999857810215121 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.521823750104981 0 0 0.4592581264399 0 0 3.24330636341996 0.33984240868832 355.5 2233 False False 0.495138489093584 0.0107661625367428 4.08269117192464 0 0 0.000707651905360176 0.99961257829147 0.999156938222445 0.999857810215121 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 2170 3787 0 0 0.00169850036174098 0.999208443271767 0.997688494809834 0.999836732216022 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.22663965322398 0.558201069943668 269 1065 False False 0 0 0 0 0 0 0 0 0 4.22663965322398 0 0 0.00169850036174098 0.999208443271767 0.997688494809834 0.999836732216022 3 3) Uncertain significance No change no 1 +Ethionamide ethA p.Phe320Ser ethA_p.Phe320Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Phe349fs ethA_p.Phe349fs 1 frameshift (see "Genomic_coordinates" sheet) 1 13 3 10 12 12 5200 15475 0.00230237912509593 0.00119022113901414 0.0040183355622907 0.99922515658294 0.998646896080726 0.999599565042795 0.5 0.291241779836211 0.708758220163788 0.23076923076923 0.0503810734911515 0.53813153923404 0.2 0.0433120051058366 0.480891133806853 0.892788461538461 0.157813886465619 3.46909072016808 1 815 2233 False False 2.97596153846153 1.22196837165508 7.24714655435819 0.000576590428598885 0.000118922595908865 0.00168410824465837 0.99922515658294 0.998646896080726 0.999599565042795 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 1 6 2 6 2168 3784 0.000921658986175115 0.000111636674590768 0.0033253435449308 0.998416886543535 0.996557436795264 0.999418810659556 0.25 0.0318540262499442 0.650855794412824 0.142857142857142 0.00361029686190058 0.578723197043195 0.142857142857142 0.00361029686190058 0.578723197043195 0.290897908979089 0.00632547789535014 2.40048675294295 0.433996233045249 217 1065 False False 0 0 0 0 0 0 0 0.581795817958179 0.0573643286211511 3.25769068238809 0.000461041954817888 1.16725035605811e-05 0.00256605588112533 0.998416886543535 0.996557436795264 0.999418810659556 15 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Phe401Val ethA_p.Phe401Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1213 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Phe414fs ethA_p.Phe414fs 1 frameshift (see "Genomic_coordinates" sheet) 1 32 25 7 28 9 5184 15478 0.00537221795855717 0.00357268007260088 0.00775505962083478 0.999418867437205 0.998897117312968 0.999734235852573 0.756756756756756 0.588008307576086 0.882274825692892 0.78125 0.600271736287892 0.90722846771528 0.735294117647058 0.556384631694893 0.871182608416491 10.6633046737213 4.47965809698225 29.2129931899699 4.93637878976558e-10 14 2233 True False 9.2889231824417 4.25734846506754 22.3882068041796 0.00479938567863313 0.00310824521326756 0.00707674097285582 0.999418867437205 0.998897117312968 0.999734235852573 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance 1 4 0 4 0 6 2170 3784 0 0 0.00169850036174098 0.998416886543535 0.996557436795264 0.999418810659556 0 0 0.4592581264399 0 0 0.602364635616474 0 0 0.4592581264399 0 0 2.64402964063323 0.303690596890216 91 1065 False False 0 0 0 0 0 0 0 0 0 1.48263576179074 0 0 0.00169850036174098 0.998416886543535 0.996557436795264 0.999418810659556 31 Evidence from ALL dataset only 2) Assoc w R - Interim No change no ALL only 1 +Ethionamide ethA p.Phe414Leu ethA_p.Phe414Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 7.19247409791798 0.577090863007554 439 2233 False False 0 0 7.19247409791798 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Phe431_Thr435del ethA_p.Phe431_Thr435del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Ethionamide ethA p.Phe431fs ethA_p.Phe431fs 1 frameshift (see "Genomic_coordinates" sheet) 1 20 9 11 9 12 5203 15475 0.00172678434382194 0.000789890217063144 0.00327543249467561 0.99922515658294 0.998646896080726 0.999599565042795 0.428571428571428 0.21819685688513 0.659793690719725 0.45 0.230577896775924 0.684721866959451 0.428571428571428 0.21819685688513 0.659793690719725 2.43347369524574 0.890713317497204 6.46422341010097 0.0659524161692051 143 2233 False False 2.23068422064193 0.829548948597721 5.77181664376584 0.00172678434382194 0.000789890217063144 0.00327543249467561 0.99922515658294 0.998646896080726 0.999599565042795 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Phe431Leu ethA_p.Phe431Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 1 4 4 4 5208 15483 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.99974171886098 0.999338830952079 0.999929622742193 0.5 0.157012770487058 0.842987229512941 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 0.743231566820276 0.0150929386779239 7.51422357280718 1 815 2233 False False 2.9729262672811 0.553517542355507 15.9639231757182 0.000191975427145325 4.860385190457e-06 0.00106914936617667 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 2167 3790 0.00138248847926267 0.000285193152965682 0.0040348522148252 1 0.999027154404229 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 556 1065 False False 0 0 0 0 0 0 0 Inf 0.721991535026265 Inf 0 0 0.00170084976888778 1 0.999027154404229 1 5 3) Uncertain significance No change no 1 +Ethionamide ethA p.Phe431Ser ethA_p.Phe431Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Phe434fs ethA_p.Phe434fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 2 1 5210 15486 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 0.666666666666666 0.0942993240502461 0.991596241340387 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0761996455851229 Inf 0.251775619655022 222.5 2233 False False 5.9447216890595 0.309382652589367 349.949104522224 0.000191901746305891 4.8585197621771e-06 0.00106873920290263 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 3 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Phe48Ser ethA_p.Phe48Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1350 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Phe48Val ethA_p.Phe48Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1240 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 586 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Phe64Cys ethA_p.Phe64Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 2 3) Uncertain significance No change no 1 +Ethionamide ethA p.Phe64fs ethA_p.Phe64fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 5209 15487 0.000575594781273983 0.000118717215010897 0.00168120176197813 1 0.999761836368682 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1334 2233 False False Inf 1.22809956796298 Inf 0 0 0.000707923512718415 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Phe64Leu ethA_p.Phe64Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Phe64Ser ethA_p.Phe64Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1365 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Phe66Leu ethA_p.Phe66Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1354 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 667 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Pro160del ethA_p.Pro160del 1 inframe_deletion (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1335 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Ethionamide ethA p.Pro160fs ethA_p.Pro160fs 1 frameshift (see "Genomic_coordinates" sheet) 1 6 5 1 5 1 5207 15486 0.000959324635456638 0.000311561141138009 0.0022373118395626 0.999935429715245 0.999640290494779 0.999998365223265 0.833333333333333 0.358765421002325 0.99578925548551 0.833333333333333 0.358765421002325 0.99578925548551 0.833333333333333 0.358765421002325 0.99578925548551 14.8703668139043 1.66317699294464 700.725693531947 0.0047929673615112 59 2233 False False 14.8703668139043 1.66317699294464 700.725693531947 0.000959324635456638 0.000311561141138009 0.0022373118395626 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 3 0 3 0 2167 3790 0.00138248847926267 0.000285193152965682 0.0040348522148252 1 0.999027154404229 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.721991535026265 Inf 0.0482234657957814 36.5 1065 False False 0 0 0 0 0 0 0 Inf 0.721991535026265 Inf 0.00138248847926267 0.000285193152965682 0.0040348522148252 1 0.999027154404229 1 24 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Pro160Ser ethA_p.Pro160Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1197 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Ethionamide ethA p.Pro160Thr ethA_p.Pro160Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 3) Uncertain significance No change no 1 +Ethionamide ethA p.Pro164Gln ethA_p.Pro164Gln 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1393 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Pro164Leu ethA_p.Pro164Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 2 2 5210 15485 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.99987085943049 0.99953357854254 0.999984360095269 0.5 0.067585986488543 0.932414013511457 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 1.48608445297504 0.0251842236737227 28.558096294943 1 815 2233 False False 2.97216890595009 0.215371636513233 40.9716636776753 0.000191901746305891 4.8585197621771e-06 0.00106873920290263 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.2999762698034 0.53686319604546 244.5 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Pro192Leu ethA_p.Pro192Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 2 3 4 3 5208 15484 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.999806289145735 0.999434000080036 0.999960050383188 0.571428571428571 0.184051567640083 0.901011721557492 0.4 0.0527449505263169 0.853367200365326 0.4 0.0527449505263169 0.853367200365326 1.98207885304659 0.165489783152662 17.3019621542704 0.605377807978316 471 2233 False False 3.96415770609319 0.670342430404991 27.0684059834314 0.000383877159309021 4.64926862896582e-05 0.00138600116078139 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 3 0 2167 3790 0.00138248847926267 0.000285193152965682 0.0040348522148252 1 0.999027154404229 1 1 0.292401773821286 1 1 0.025 1 1 0.025 1 Inf 0.044824287936295 Inf 0.36388049681101 107 1065 False False 0 0 0 0 0 0 0 Inf 0.721991535026265 Inf 0.000461254612546125 1.16778875252514e-05 0.00256723823850048 1 0.999027154404229 1 3 3) Uncertain significance No change no 1 +Ethionamide ethA p.Pro192Ser ethA_p.Pro192Ser 1 missense_variant (see "Genomic_coordinates" sheet) 2 14 1 13 3 13 5209 15474 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.999160586298185 0.998565004766387 0.999552974256682 0.1875 0.0404737339059459 0.456456546231611 0.0714285714285714 0.00180678065912538 0.338684489931821 0.0714285714285714 0.00180678065912538 0.338684489931821 0.228509827665135 0.00537968218007581 1.52211467185968 0.21308851857201 187 2233 False False 0.685529482995407 0.125257070543251 2.49616387137143 0.00019193857965451 4.85945229729366e-06 0.00106894424519385 0.999160586298185 0.998565004766387 0.999552974256682 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 638 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 4 3) Uncertain significance No change no 1 +Ethionamide ethA p.Pro192Thr ethA_p.Pro192Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 11 2 9 7 11 5205 15476 0.00134305448963929 0.000540142673187124 0.00276523543039201 0.999289726867695 0.998729481387772 0.999645382583254 0.388888888888888 0.172985854789751 0.642548794106937 0.181818181818181 0.0228311982999596 0.517755852360172 0.153846153846153 0.0192066719825284 0.454471055676557 0.660732201942576 0.0694488646553198 3.19350763202391 0.741281148186267 484 2233 False False 1.89209676010828 0.621557356329603 5.34865691160257 0.000384098329172268 4.65194748839127e-05 0.00138679930124962 0.999289726867695 0.998729481387772 0.999645382583254 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 1 3 5 4 2165 3786 0.00230414746543778 0.000748560476988087 0.00536885389822181 0.998944591029023 0.997299958285064 0.999712364080324 0.555555555555555 0.212008506778868 0.863004337734833 0.25 0.00630946320970987 0.805879550316756 0.2 0.00505076337946806 0.716417936118089 0.582909930715935 0.0111032305010384 7.26553383420078 1 405 1065 False False 0 0 0 0 0 0 0 2.18591224018475 0.469891217133802 11.0275815802638 0.000461680517082179 1.16886703685344e-05 0.00256960622502152 0.998944591029023 0.997299958285064 0.999712364080324 30 3) Uncertain significance No change no 1 +Ethionamide ethA p.Pro209fs ethA_p.Pro209fs 1 frameshift (see "Genomic_coordinates" sheet) 1 26 0 26 0 26 5212 15461 0 0 0.000707516179821284 0.998321172596371 0.997541089641407 0.998903050216343 0 0 0.132274604497754 0 0 0.132274604497754 0 0 0.132274604497754 0 0 0.452441666093471 0.00094769443286063 40 2233 False False 0 0 0.452441666093471 0 0 0.000707516179821284 0.998321172596371 0.997541089641407 0.998903050216343 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 26 0 26 0 26 2170 3764 0 0 0.00169850036174098 0.993139841688654 0.989964327935836 0.99551396597316 0 0 0.132274604497754 0 0 0.132274604497754 0 0 0.132274604497754 0 0 0.264796007269256 1.20511860895389e-05 9 1065 True False 0 0 0 0 0 0 0 0 0 0.264796007269256 0 0 0.00169850036174098 0.993139841688654 0.989964327935836 0.99551396597316 4 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Pro209Ser ethA_p.Pro209Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Pro230fs ethA_p.Pro230fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0761850255002428 Inf 0.251811769253067 330.5 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Pro230Gln ethA_p.Pro230Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethionamide ethA p.Pro230Leu ethA_p.Pro230Leu 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 0 1 4 8 5208 15479 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.99948343772196 0.998982421476308 0.999776959534822 0.333333333333333 0.0992460911495833 0.651124493581186 0 0 0.975 0 0 0.369416647552819 0 0 115.713877255831 1 815 2233 False False 1.48607910906298 0.327343181309975 5.54928881094045 0 0 0.000708059394597755 0.99948343772196 0.998982421476308 0.999776959534822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 7 2166 3783 0.00184331797235023 0.00050246332413509 0.00471284227984187 0.998153034300791 0.996198270365656 0.999257111678459 0.363636363636363 0.109263443819098 0.692095284988322 NA NA NA 0 0 0.409616397225003 NA NA NA NA 603 1065 False False 0 0 0 0 0 0 0 0.998021369212505 0.213995590230827 3.93100613936619 0 0 0.00170163434960586 0.998153034300791 0.996198270365656 0.999257111678459 2 3) Uncertain significance No change no 1 +Ethionamide ethA p.Pro257Ala ethA_p.Pro257Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 2.97179044329303 0.0378514560716107 232.854636669753 0.440205269357083 400.5 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Pro257Arg ethA_p.Pro257Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 2 1 2 1 5210 15486 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 5.9447216890595 0.309382652589367 349.949104522224 0.158265844695452 166.5 2233 False False 5.9447216890595 0.309382652589367 349.949104522224 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Pro257fs ethA_p.Pro257fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 2 1 5210 15486 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 0.666666666666666 0.0942993240502461 0.991596241340387 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0761996455851229 Inf 0.251775619655022 222.5 2233 False False 5.9447216890595 0.309382652589367 349.949104522224 0.000191901746305891 4.8585197621771e-06 0.00106873920290263 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 613 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Pro257Gln ethA_p.Pro257Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Pro257Leu ethA_p.Pro257Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 4 0 5208 15487 0.00076745970836531 0.000209145270149598 0.00196382534650725 1 0.999761836368682 1 1 0.397635364383525 1 1 0.025 1 1 0.025 1 Inf 0.0762338250501108 Inf 0.251691148047931 196 2233 False False Inf 1.96217557721065 Inf 0.000191975427145325 4.860385190457e-06 0.00106914936617667 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 2167 3790 0.00138248847926267 0.000285193152965682 0.0040348522148252 1 0.999027154404229 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 604 1065 False False 0 0 0 0 0 0 0 Inf 0.721991535026265 Inf 0 0 0.00170084976888778 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Pro257Ser ethA_p.Pro257Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 2 7 4 9 5208 15478 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.999418867437205 0.998897117312968 0.999734235852573 0.307692307692307 0.0909203945720966 0.614261661750705 0.222222222222222 0.0281449734778982 0.600093573716312 0.181818181818181 0.0228311982999596 0.517755852360172 0.849133201667763 0.0860425739450836 4.46157061823659 1 815 2233 False False 1.32087386926096 0.29709911776039 4.73500643877249 0.000383877159309021 4.64926862896582e-05 0.00138600116078139 0.999418867437205 0.998897117312968 0.999734235852573 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 2 3 3 3 2167 3787 0.00138248847926267 0.000285193152965682 0.0040348522148252 0.999208443271767 0.997688494809834 0.999836732216022 0.5 0.118117248757025 0.881882751242974 0.4 0.0527449505263169 0.853367200365326 0.4 0.0527449505263169 0.853367200365326 1.16505153053376 0.09720649269205 10.176786167471 1 405 1065 False False 0 0 0 0 0 0 0 1.74757729580064 0.233837130446773 13.0617462404894 0.000922083909635776 0.000111688152776852 0.00332687482132476 0.999208443271767 0.997688494809834 0.999836732216022 25 3) Uncertain significance No change no 1 +Ethionamide ethA p.Pro257Thr ethA_p.Pro257Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Pro273Arg ethA_p.Pro273Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Pro273Leu ethA_p.Pro273Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 4 1 5208 15486 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.999935429715245 0.999640290494779 0.999998365223265 0.8 0.28358206388191 0.994949236620532 0 0 0.975 0 0 0.975 0 0 115.766108003968 1 815 2233 False False 11.8940092165898 1.17652678598182 583.885453446482 0 0 0.000708059394597755 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 0 2166 3790 0.00184331797235023 0.00050246332413509 0.00471284227984187 1 0.999027154404229 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 656 1065 False False 0 0 0 0 0 0 0 Inf 1.15374841388447 Inf 0 0 0.00170163434960586 1 0.999027154404229 1 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Pro273Ser ethA_p.Pro273Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1355 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 668 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Pro284_Leu344del ethA_p.Pro284_Leu344del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Ethionamide ethA p.Pro284fs ethA_p.Pro284fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1314 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 639 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Pro288Arg ethA_p.Pro288Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Pro288Ser ethA_p.Pro288Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 0 5208 15487 0.00076745970836531 0.000209145270149598 0.00196382534650725 1 0.999761836368682 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 1302 2233 False False Inf 1.96217557721065 Inf 0 0 0.000708059394597755 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 626 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Pro28fs ethA_p.Pro28fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Pro297_Asn388del ethA_p.Pro297_Asn388del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Ethionamide ethA p.Pro297Ser ethA_p.Pro297Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1228 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 572 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Pro334Ala ethA_p.Pro334Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 75 4 71 22 82 5190 15405 0.00422102839600921 0.00264712925735376 0.00638375303230951 0.994705236650093 0.993432003966403 0.995786768135602 0.211538461538461 0.137572624174558 0.302568831039446 0.0533333333333333 0.0147207646591781 0.130960807278474 0.0465116279069767 0.0128163524215735 0.114825497538114 0.167222991125946 0.0443284540088646 0.447656496659809 1.19413483828227e-05 26 2233 True False 0.796348512618074 0.472987970121045 1.28932093753663 0.000770119368502117 0.000209870204190434 0.00197062696645152 0.994705236650093 0.993432003966403 0.995786768135602 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 26 2 24 11 27 2159 3763 0.00506912442396313 0.00253312289257636 0.00905192238910812 0.99287598944591 0.989651745715379 0.995300136009189 0.289473684210526 0.154246286787909 0.459032066924292 0.0769230769230769 0.00945539100371274 0.251302916695373 0.0689655172413793 0.00846396225300182 0.227661889944486 0.145244712058051 0.0166165443699345 0.586091630555399 0.00160101075030381 20 1065 False False 0 0 0 0 0 0 0 0.710085258950474 0.317243592851672 1.48256387283367 0.000925497454881999 0.00011210169371193299 0.00333917598969124 0.99287598944591 0.989651745715379 0.995300136009189 69 3) Uncertain significance No change no 1 +Ethionamide ethA p.Pro378Leu ethA_p.Pro378Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 77 30 47 34 60 5178 15427 0.00652340752110514 0.00452175606360518 0.00910398409556301 0.996125782914702 0.995015890582708 0.997042301362845 0.361702127659574 0.265082479895898 0.467294398609017 0.389610389610389 0.280462261179298 0.507519641324135 0.333333333333333 0.237432427440536 0.440549373012805 1.90170360691304 1.1598809432024 3.07392059943973 0.00800903392708507 63 2233 False False 1.68829020213724 1.07324271627808 2.61673507305237 0.00576036866359447 0.00388977156752248 0.00821315228289565 0.996125782914702 0.995015890582708 0.997042301362845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 6 4 8 6 2162 3784 0.00368663594470046 0.00159293019145598 0.00725115327762171 0.998416886543535 0.996557436795264 0.999418810659556 0.571428571428571 0.288609400038307 0.823388910017882 0.6 0.262378076606945 0.878447741880172 0.5 0.210944638239296 0.789055361760703 2.62534690101757 0.621687775468559 12.6633164097359 0.184867660577703 75 1065 False False 0 0 0 0 0 0 0 2.3336416897934 0.70888068184125 8.16994055429741 0.00276752767527675 0.00101629004016278 0.00601393982555873 0.998416886543535 0.996557436795264 0.999418810659556 31 Assoc w RI 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Ethionamide ethA p.Pro378Ser ethA_p.Pro378Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Pro422fs ethA_p.Pro422fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 2 0 5 0 5207 15487 0.000959324635456638 0.000311561141138009 0.0022373118395626 1 0.999761836368682 1 1 0.478176249895018 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.55842723294384 Inf 0.063339333125568 116 2233 False False Inf 2.72427826476923 Inf 0.00038395085429065 4.65016123923256e-05 0.00138626710550647 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 4 0 2166 3790 0.00184331797235023 0.00050246332413509 0.00471284227984187 1 0.999027154404229 1 1 0.397635364383525 1 1 0.025 1 1 0.025 1 Inf 0.0448449730789031 Inf 0.363773711599798 105 1065 False False 0 0 0 0 0 0 0 Inf 1.15374841388447 Inf 0.000461467466543608 1.16832764589418e-05 0.00256842168596313 1 0.999027154404229 1 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Pro422Leu ethA_p.Pro422Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 4 0 5208 15487 0.00076745970836531 0.000209145270149598 0.00196382534650725 1 0.999761836368682 1 1 0.397635364383525 1 1 0.025 1 1 0.025 1 Inf 0.0762338250501108 Inf 0.251691148047931 196 2233 False False Inf 1.96217557721065 Inf 0.000191975427145325 4.860385190457e-06 0.00106914936617667 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 3 0 2167 3790 0.00138248847926267 0.000285193152965682 0.0040348522148252 1 0.999027154404229 1 1 0.292401773821286 1 1 0.025 1 1 0.025 1 Inf 0.044824287936295 Inf 0.36388049681101 107 1065 False False 0 0 0 0 0 0 0 Inf 0.721991535026265 Inf 0.000461254612546125 1.16778875252514e-05 0.00256723823850048 1 0.999027154404229 1 3 3) Uncertain significance No change no 1 +Ethionamide ethA p.Pro436Ala ethA_p.Pro436Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Pro436fs ethA_p.Pro436fs 1 frameshift (see "Genomic_coordinates" sheet) 1 3 1 2 1 3 5211 15484 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999806289145735 0.999434000080036 0.999960050383188 0.25 0.00630946320970987 0.805879550316756 0.333333333333333 0.00840375865961264 0.905700675949754 0.25 0.00630946320970987 0.805879550316756 1.48570331990021 0.0251777656076324 28.5507961912322 1 815 2233 False False 0.990468879933474 0.0188633706776044 12.3373543450537 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 4 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Pro436Leu ethA_p.Pro436Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 0 5208 15487 0.00076745970836531 0.000209145270149598 0.00196382534650725 1 0.999761836368682 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 1293 2233 False False Inf 1.96217557721065 Inf 0 0 0.000708059394597755 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 618 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0 0 0.00170006591133688 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Pro447Leu ethA_p.Pro447Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 5 1 5207 15486 0.000959324635456638 0.000311561141138009 0.0022373118395626 0.999935429715245 0.999640290494779 0.999998365223265 0.833333333333333 0.358765421002325 0.99578925548551 0 0 0.975 0 0 0.975 0 0 115.788300564918 1 815 2233 False False 14.8703668139043 1.66317699294464 700.725693531947 0 0 0.00070819532865061 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 614 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Pro447Ser ethA_p.Pro447Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 1 5 1 5 5211 15482 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999677148576225 0.999246734667469 0.999895162977301 0.166666666666666 0.00421074451448947 0.641234578997674 0.166666666666666 0.00421074451448947 0.641234578997674 0.166666666666666 0.00421074451448947 0.641234578997674 0.594204567261562 0.012564591702922 5.31232633024241 1 815 2233 False False 0.594204567261562 0.012564591702922 5.31232633024241 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999677148576225 0.999246734667469 0.999895162977301 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.2999762698034 0.53686319604546 244.5 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 3 3) Uncertain significance No change no 1 +Ethionamide ethA p.Pro447Thr ethA_p.Pro447Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1356 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 669 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Pro454Leu ethA_p.Pro454Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 1 3 5 7 5207 15480 0.000959324635456638 0.000311561141138009 0.0022373118395626 0.999548008006715 0.999068946905294 0.99981825708278 0.416666666666666 0.15165222980843 0.723330314317894 0.25 0.00630946320970987 0.805879550316756 0.125 0.0031597235312519 0.526509670875206 0.990973689264451 0.0188729820513644 12.3436429846349 1 496.5 2233 False False 2.12351504842382 0.531184609205194 7.77587371229446 0.000192012288786482 4.86131844187338e-06 0.00106935456589642 0.999548008006715 0.999068946905294 0.99981825708278 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 5 2169 3785 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.998680738786279 0.996923992057454 0.999571505100005 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.975 0 0 0.521823750104981 0 0 68.0034183572518 1 405 1065 False False 0 0 0 0 0 0 0 0.349008759797141 0.00737988563135068 3.12211888418912 0 0 0.0016992827759538 0.998680738786279 0.996923992057454 0.999571505100005 11 3) Uncertain significance No change no 1 +Ethionamide ethA p.Pro454Ser ethA_p.Pro454Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 2 3) Uncertain significance No change no 1 +Ethionamide ethA p.Pro454Thr ethA_p.Pro454Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Pro51Arg ethA_p.Pro51Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 2 3 2 3 5210 15484 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999806289145735 0.999434000080036 0.999960050383188 0.4 0.0527449505263169 0.853367200365326 0.4 0.0527449505263169 0.853367200365326 0.4 0.0527449505263169 0.853367200365326 1.98131797824696 0.165426255296508 17.2953159846476 0.605417024238846 473.5 2233 False False 1.98131797824696 0.165426255296508 17.2953159846476 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Pro51His ethA_p.Pro51His 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 3 5 3 5 5209 15482 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.999677148576225 0.999246734667469 0.999895162977301 0.375 0.0852334141372535 0.755136783633448 0.375 0.0852334141372535 0.755136783633448 0.375 0.0852334141372535 0.755136783633448 1.78329813783835 0.27682812068913 9.16959691894064 0.424094458747099 371.5 2233 False False 1.78329813783835 0.27682812068913 9.16959691894064 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.999677148576225 0.999246734667469 0.999895162977301 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 9 3) Uncertain significance No change no 1 +Ethionamide ethA p.Pro51Leu ethA_p.Pro51Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 1 4 1 4 5211 15483 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99974171886098 0.999338830952079 0.999929622742193 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 0.742803684513529 0.0150842538989179 7.50989306640636 1 815 2233 False False 0.742803684513529 0.0150842538989179 7.50989306640636 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 1 3 1 3 2169 3787 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999208443271767 0.997688494809834 0.999836732216022 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.581988627631781 0.0110856993615618 7.25404417491437 1 289.5 1065 False False 0 0 0 0 0 0 0 0.581988627631781 0.0110856993615618 7.25404417491437 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999208443271767 0.997688494809834 0.999836732216022 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Pro51Ser ethA_p.Pro51Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 11 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Pro68fs ethA_p.Pro68fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Pro68Leu ethA_p.Pro68Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ser106fs ethA_p.Ser106fs 1 frameshift (see "Genomic_coordinates" sheet) 1 5 3 2 3 3 5209 15484 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.999806289145735 0.999434000080036 0.999960050383188 0.5 0.118117248757025 0.881882751242974 0.6 0.146632799634673 0.947255049473683 0.5 0.118117248757025 0.881882751242974 4.45882127087732 0.510568075410789 53.3659437924214 0.105410158799787 150 2233 False False 2.97254751391821 0.397987980392264 22.1986618481397 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 1 2 2169 3788 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999472295514512 0.998095063429584 0.999936086148442 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.87321346242508 0.0147995228023146 16.7833115850342 1 289.5 1065 False False 0 0 0 0 0 0 0 0.87321346242508 0.0147995228023146 16.7833115850342 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999472295514512 0.998095063429584 0.999936086148442 8 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Ser110Pro ethA_p.Ser110Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Ser110Trp ethA_p.Ser110Trp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 1 5210 15486 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 1294 2233 False False 5.9447216890595 0.309382652589367 349.949104522224 0 0 0.000707787682982558 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Ser122fs ethA_p.Ser122fs 1 frameshift (see "Genomic_coordinates" sheet) 1 8 8 0 10 0 5202 15487 0.00191864927091327 0.000920438305261622 0.00352562450313611 1 0.999761836368682 1 1 0.691502892181239 1 1 0.63058335244718 1 1 0.63058335244718 1 Inf 5.07884130942793 Inf 1.60581331867273e-05 28 2233 True False Inf 6.6703028343942 Inf 0.00153550863723608 0.000663149391996922 0.00302331034879617 1 0.999761836368682 1 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Evidence from ALL dataset only 2) Assoc w R - Interim No change no ALL only 1 +Ethionamide ethA p.Ser138Arg ethA_p.Ser138Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 1 6 4 6 5208 15481 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.99961257829147 0.999156938222445 0.999857810215121 0.4 0.121552258119827 0.737621923393055 0.142857142857142 0.00361029686190058 0.578723197043195 0.142857142857142 0.00361029686190058 0.578723197043195 0.495423707117255 0.0107723605172408 4.08504346479616 0.687797427631698 478 2233 False False 1.98169482846902 0.411136149006771 8.35986151202817 0.000191975427145325 4.860385190457e-06 0.00106914936617667 0.99961257829147 0.999156938222445 0.999857810215121 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 1 5 3 5 2167 3785 0.00138248847926267 0.000285193152965682 0.0040348522148252 0.998680738786279 0.996923992057454 0.999571505100005 0.375 0.0852334141372535 0.755136783633448 0.166666666666666 0.00421074451448947 0.641234578997674 0.166666666666666 0.00421074451448947 0.641234578997674 0.349330872173511 0.00738668908958601 3.12499935844167 0.426510808620538 215 1065 False False 0 0 0 0 0 0 0 1.04799261652053 0.1625796363774 5.39210287464773 0.000461254612546125 1.16778875252514e-05 0.00256723823850048 0.998680738786279 0.996923992057454 0.999571505100005 4 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ser138fs ethA_p.Ser138fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 3 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Ser138Ile ethA_p.Ser138Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 5209 15487 0.000575594781273983 0.000118717215010897 0.00168120176197813 1 0.999761836368682 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1214 2233 False False Inf 1.22809956796298 Inf 0 0 0.000707923512718415 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 562 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ser148fs ethA_p.Ser148fs 1 frameshift (see "Genomic_coordinates" sheet) 1 5 5 0 6 0 5206 15487 0.00115118956254796 0.000422579736688136 0.00250395844332671 1 0.999761836368682 1 1 0.540741873560099 1 1 0.478176249895018 1 1 0.478176249895018 1 Inf 2.72480119333087 Inf 0.00101004246626816 43 2233 False False Inf 3.50093622554567 Inf 0.000959508731529456 0.000311620943906444 0.0022377409088434 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Ser15Cys ethA_p.Ser15Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ser15Phe ethA_p.Ser15Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Ser15Pro ethA_p.Ser15Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Ser183Arg ethA_p.Ser183Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 2 5209 15485 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.99987085943049 0.99953357854254 0.999984360095269 0.6 0.146632799634673 0.947255049473683 0 0 0.975 0 0 0.841886116991581 0 0 115.736463845492 1 815 2233 False False 4.45910923401804 0.510601005330275 53.3693689348625 0 0 0.000707923512718415 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 68.0751891811639 1 405 1065 False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 0 0 0.0016992827759538 0.999736147757256 0.998530795728906 0.999993319861894 2 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ser183Gly ethA_p.Ser183Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.2999762698034 0.53686319604546 244.5 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ser18Arg ethA_p.Ser18Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Ser18fs ethA_p.Ser18fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Ser18Gly ethA_p.Ser18Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1384 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 683 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Ser18Thr ethA_p.Ser18Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1303 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 627 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Ser197Ala ethA_p.Ser197Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1203 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 553 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0 0 0.00170006591133688 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Ser197Pro ethA_p.Ser197Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1304 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 628 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Ser197* ethA_p.Ser197* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Ser208fs ethA_p.Ser208fs 1 frameshift (see "Genomic_coordinates" sheet) 1 3 0 3 3 4 5209 15483 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.99974171886098 0.999338830952079 0.999929622742193 0.428571428571428 0.0989882784425078 0.815948432359917 0 0 0.707598226178713 0 0 0.602364635616474 0 0 7.19615291073443 0.57714376022645 455 2233 False False 2.2292666538683 0.326438409930677 13.182222747906 0 0 0.000707923512718415 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 557 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Ser208Leu ethA_p.Ser208Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 2 1 2 2 5210 15485 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.99987085943049 0.99953357854254 0.999984360095269 0.5 0.067585986488543 0.932414013511457 0.666666666666666 0.0942993240502461 0.991596241340387 0.5 0.067585986488543 0.932414013511457 5.94433781190019 0.309362673517028 349.926564893359 0.158279596016546 173 2233 False False 2.97216890595009 0.215371636513233 40.9716636776753 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.328088282833639 Inf 0.132525557754273 60 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 3 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ser208Pro ethA_p.Ser208Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 5 1 6 3 5206 15484 0.00115118956254796 0.000422579736688136 0.00250395844332671 0.999806289145735 0.999434000080036 0.999960050383188 0.666666666666666 0.29929505620854 0.925145368580308 0.833333333333333 0.358765421002325 0.99578925548551 0.625 0.244863216366551 0.914766585862746 14.8713023434498 1.66328148663701 700.769598213764 0.0047919010582343 58 2233 False False 5.94852093737994 1.26973821980427 36.7666540443382 0.000959508731529456 0.000311620943906444 0.0022377409088434 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 5 1 5 3 2165 3787 0.00230414746543778 0.000748560476988087 0.00536885389822181 0.999208443271767 0.997688494809834 0.999836732216022 0.625 0.244863216366551 0.914766585862746 0.833333333333333 0.358765421002325 0.99578925548551 0.625 0.244863216366551 0.914766585862746 8.7459584295612 0.977411635155062 412.906218810927 0.0267216886648933 32 1065 False False 0 0 0 0 0 0 0 2.9153194765204 0.566479632607818 18.786985063018 0.00230414746543778 0.000748560476988087 0.00536885389822181 0.999208443271767 0.997688494809834 0.999836732216022 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ser208* ethA_p.Ser208* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Ser214fs ethA_p.Ser214fs 1 frameshift (see "Genomic_coordinates" sheet) 1 9 3 6 4 6 5208 15481 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.99961257829147 0.999156938222445 0.999857810215121 0.4 0.121552258119827 0.737621923393055 0.333333333333333 0.0748546314196918 0.700704943791459 0.333333333333333 0.0748546314196918 0.700704943791459 1.48627112135176 0.240419595354088 6.96203682466896 0.700329882546658 481.5 2233 False False 1.98169482846902 0.411136149006771 8.35986151202817 0.000575705238917674 0.00011874000007229 0.00168152420898675 0.99961257829147 0.999156938222445 0.999857810215121 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 3 2 4 2 2166 3788 0.00184331797235023 0.00050246332413509 0.00471284227984187 0.999472295514512 0.998095063429584 0.999936086148442 0.666666666666666 0.222778095503512 0.956728131707258 0.6 0.146632799634673 0.947255049473683 0.6 0.146632799634673 0.947255049473683 2.62326869806094 0.300188461326621 31.4229433051183 0.361175070271979 100 1065 False False 0 0 0 0 0 0 0 3.49769159741458 0.50070237346979 38.6880977910277 0.00138312586445366 0.000285324680875951 0.00403670997741914 0.999472295514512 0.998095063429584 0.999936086148442 57 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Ser214Pro ethA_p.Ser214Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1295 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 619 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Ser251_Ala252insGly ethA_p.Ser251_Ala252insGly 1 inframe_insertion (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1265 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Ethionamide ethA p.Ser251Arg ethA_p.Ser251Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 115.699581334225 1 815 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 68.0751891811639 1 405 1065 False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 0 0 0.0016992827759538 0.999736147757256 0.998530795728906 0.999993319861894 3 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ser251fs ethA_p.Ser251fs 1 frameshift (see "Genomic_coordinates" sheet) 1 25 14 11 30 16 5182 15471 0.00575594781273983 0.00388678380786634 0.00820685679375776 0.99896687544392 0.998322811196946 0.999409368388177 0.652173913043478 0.497509949327036 0.786456445748494 0.56 0.349281633991335 0.755976334852791 0.466666666666666 0.283418079183537 0.656744761839265 3.79976141188028 1.60121857370168 9.25391593630671 0.00167799762034648 49 2233 False False 5.59786279428792 2.95282540325841 11.0038083028828 0.00269438029253271 0.00147380136589335 0.00451658406750092 0.99896687544392 0.998322811196946 0.999409368388177 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 3 1 8 2 2162 3788 0.00368663594470046 0.00159293019145598 0.00725115327762171 0.999472295514512 0.998095063429584 0.999936086148442 0.8 0.443904537692358 0.974789273673166 0.75 0.194120449683243 0.99369053679029 0.6 0.146632799634673 0.947255049473683 5.25624421831637 0.421612789017148 275.591489084498 0.139788622792345 65 1065 False False 0 0 0 0 0 0 0 7.00832562442183 1.39645399072679 67.8805502516635 0.00138568129330254 0.000285852007943472 0.00404415816669477 0.999472295514512 0.998095063429584 0.999936086148442 25 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Ser266Arg ethA_p.Ser266Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 345 10 335 201 423 5011 15064 0.0385648503453568 0.0335012016039857 0.044153185892966 0.972686769548653 0.969996923848745 0.975197026872197 0.322115384615384 0.285566117619132 0.360358147813648 0.0289855072463768 0.0139853762832822 0.0526580926947649 0.023094688221709 0.0111290750254975 0.0420609183387488 0.0897369071624515 0.042607136100281 0.167278667383035 3.10597230279664e-29 7 2233 True False 1.42847154699377 1.19791357500076 1.69898175478486 0.00199163513244373 0.00095546666845138 0.00365962794806131 0.972686769548653 0.969996923848745 0.975197026872197 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 52 3 49 34 66 2136 3724 0.0156682027649769 0.0108744540073486 0.0218264651060431 0.982585751978892 0.977897463533026 0.986506882352767 0.34 0.248223501544844 0.441533267750958 0.0576923076923076 0.0120593180267384 0.159473358638591 0.0434782608695652 0.00905760735881503 0.121847149365623 0.106741573033707 0.0212824389581826 0.331510821052188 5.73069795057263e-07 8 1065 True False 0 0 0 0 0 0 0 0.898138690273521 0.573608469362188 1.38370908396997 0.00140252454417952 0.000289327722715928 0.00409324948820242 0.982585751978892 0.977897463533026 0.986506882352767 405 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ser266fs ethA_p.Ser266fs 1 frameshift (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 5212 15483 0 0 0.000707516179821284 0.99974171886098 0.999338830952079 0.999929622742193 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 4.5014696306354 0.578098957200874 462.5 2233 False False 0 0 4.5014696306354 0 0 0.000707516179821284 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 2170 3786 0 0 0.00169850036174098 0.998944591029023 0.997299958285064 0.999712364080324 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.6454264678615 0.303692649321994 95 1065 False False 0 0 0 0 0 0 0 0 0 2.6454264678615 0 0 0.00169850036174098 0.998944591029023 0.997299958285064 0.999712364080324 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Ser31fs ethA_p.Ser31fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 2.97179044329303 0.0378514560716107 232.854636669753 0.440205269357083 400.5 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Ser329Leu ethA_p.Ser329Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 5211 15485 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 115.692124084117 1 815 2233 False False 1.48579927077336 0.0251793916671698 28.5526337681963 0 0 0.000707651905360176 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 596 1065 False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 0 0 0.0016992827759538 0.999736147757256 0.998530795728906 0.999993319861894 2 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Ser329Pro ethA_p.Ser329Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1222 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ser375fs ethA_p.Ser375fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.2999762698034 0.53686319604546 244.5 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Ser375Pro ethA_p.Ser375Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 7.19247409791798 0.577090863007554 439 2233 False False 0 0 7.19247409791798 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 2170 3787 0 0 0.00169850036174098 0.999208443271767 0.997688494809834 0.999836732216022 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.22663965322398 0.558201069943668 269 1065 False False 0 0 0 0 0 0 0 0 0 4.22663965322398 0 0 0.00169850036174098 0.999208443271767 0.997688494809834 0.999836732216022 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Ser375Tyr ethA_p.Ser375Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 5 6 5207 15481 0.000959324635456638 0.000311561141138009 0.0022373118395626 0.99961257829147 0.999156938222445 0.999857810215121 0.454545454545454 0.167488094063707 0.766206402340654 0 0 0.521823750104981 0 0 0.4592581264399 0 0 3.24580006323668 0.339915209204759 357 2233 False False 2.47759426413161 0.597847637196402 9.74567065988451 0 0 0.00070819532865061 0.99961257829147 0.999156938222445 0.999857810215121 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 3 5 2167 3785 0.00138248847926267 0.000285193152965682 0.0040348522148252 0.998680738786279 0.996923992057454 0.999571505100005 0.375 0.0852334141372535 0.755136783633448 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.90808528624328 0.166143033412635 74 1065 False False 0 0 0 0 0 0 0 1.04799261652053 0.1625796363774 5.39210287464773 0 0 0.00170084976888778 0.998680738786279 0.996923992057454 0.999571505100005 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ser390fs ethA_p.Ser390fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Ser390Phe ethA_p.Ser390Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 24 19 5 19 5 5193 15482 0.00364543361473522 0.00219617244689937 0.00568696754173622 0.999677148576225 0.999246734667469 0.999895162977301 0.791666666666666 0.578487156362747 0.928681382801945 0.791666666666666 0.578487156362747 0.928681382801945 0.791666666666666 0.578487156362747 0.928681382801945 11.3290198343924 4.08873553275344 38.8353453222621 4.43631708217048e-08 18 2233 True False 11.3290198343924 4.08873553275344 38.8353453222621 0.00364543361473522 0.00219617244689937 0.00568696754173622 0.999677148576225 0.999246734667469 0.999895162977301 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 2 Assoc w RI Evidence from ALL dataset only 2) Assoc w R - Interim No change yes ALL only 1 +Ethionamide ethA p.Ser399Leu ethA_p.Ser399Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 1 4 1 4 5211 15483 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99974171886098 0.999338830952079 0.999929622742193 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 0.742803684513529 0.0150842538989179 7.50989306640636 1 815 2233 False False 0.742803684513529 0.0150842538989179 7.50989306640636 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ser399Pro ethA_p.Ser399Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Ser399* ethA_p.Ser399* 1 stop_gained (see "Genomic_coordinates" sheet) 2 1 0 1 32 3 5180 15484 0.00613967766692248 0.00420321397869361 0.00865643184162767 0.999806289145735 0.999434000080036 0.999960050383188 0.914285714285714 0.769424981341122 0.981962360185782 0 0 0.975 0 0 0.707598226178713 0 0 116.375729300546 1 815 2233 False False 31.8846846846846 9.96885457131717 163.056702685613 0 0 0.000711885380037573 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 698 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 4 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Ser40Pro ethA_p.Ser40Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.2999762698034 0.53686319604546 244.5 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Ser424fs ethA_p.Ser424fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1319 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Ser424Leu ethA_p.Ser424Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ser442fs ethA_p.Ser442fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Ser451fs ethA_p.Ser451fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 2 0 3 0 5209 15487 0.000575594781273983 0.000118717215010897 0.00168120176197813 1 0.999761836368682 1 1 0.292401773821286 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.558212886044429 Inf 0.0633757357427127 118.5 2233 False False Inf 1.22809956796298 Inf 0.000383803492611782 4.64837636131093e-05 0.00138573531807565 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Ser55Ala ethA_p.Ser55Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 5 3 5207 15484 0.000959324635456638 0.000311561141138009 0.0022373118395626 0.999806289145735 0.999434000080036 0.999960050383188 0.625 0.244863216366551 0.914766585862746 0 0 0.841886116991581 0 0 0.707598226178713 0 0 15.837462361328 1 496.5 2233 False False 4.95614877408616 0.963790796814113 31.9243794332185 0 0 0.00070819532865061 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 578 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 2 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ser55Cys ethA_p.Ser55Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 5211 15485 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 115.692124084117 1 815 2233 False False 1.48579927077336 0.0251793916671698 28.5526337681963 0 0 0.000707651905360176 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 68.0259170395529 1 405 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 16 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ser55Pro ethA_p.Ser55Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 4 1 5208 15486 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.999935429715245 0.999640290494779 0.999998365223265 0.8 0.28358206388191 0.994949236620532 0 0 0.975 0 0 0.975 0 0 115.766108003968 1 815 2233 False False 11.8940092165898 1.17652678598182 583.885453446482 0 0 0.000708059394597755 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ser57Phe ethA_p.Ser57Phe 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1270 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Ser57Pro ethA_p.Ser57Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Ser57Tyr ethA_p.Ser57Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 11 10 1 11 1 5201 15486 0.0021105141980046 0.00105401717787221 0.00377314786388412 0.999935429715245 0.999640290494779 0.999998365223265 0.916666666666666 0.615203834849055 0.997892406768139 0.909090909090909 0.587220083011617 0.997701027786185 0.909090909090909 0.587220083011617 0.997701027786185 29.7750432609113 4.23364480736179 1283.77924951433 8.62622360487722e-06 23 2233 True False 32.7525475870024 4.75807868864481 1399.79305488175 0.00191901746305891 0.000920615010321175 0.00352630053161608 0.999935429715245 0.999640290494779 0.999998365223265 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Assoc w RI Evidence from ALL dataset only 2) Assoc w R - Interim no change yes ALL only 1 +Ethionamide ethA p.Thr117Pro ethA_p.Thr117Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 5211 15484 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999806289145735 0.999434000080036 0.999960050383188 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 7.19385477482889 0.57711071317492 450 2233 False False 0.990468879933474 0.0188633706776044 12.3373543450537 0 0 0.000707651905360176 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Thr125fs ethA_p.Thr125fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Thr125Met ethA_p.Thr125Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1215 2233 False False 0 0 7.19247409791798 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethionamide ethA p.Thr130fs ethA_p.Thr130fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Thr186fs ethA_p.Thr186fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0762045661509476 Inf 0.251763455406319 213.5 2233 False False Inf 0.55810577429468 Inf 0.000191901746305891 4.8585197621771e-06 0.00106873920290263 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Thr186Met ethA_p.Thr186Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Thr186Pro ethA_p.Thr186Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0762045661509476 Inf 0.251763455406319 213.5 2233 False False Inf 0.55810577429468 Inf 0.000191901746305891 4.8585197621771e-06 0.00106873920290263 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 620 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 4 3) Uncertain significance No change no 1 +Ethionamide ethA p.Thr189Lys ethA_p.Thr189Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 2.97179044329303 0.0378514560716107 232.854636669753 0.440205269357083 400.5 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Thr189Met ethA_p.Thr189Met 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1329 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Thr2_Met41del ethA_p.Thr2_Met41del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 1 0 3 0 5209 15487 0.000575594781273983 0.000118717215010897 0.00168120176197813 1 0.999761836368682 1 1 0.292401773821286 1 1 0.025 1 1 0.025 1 Inf 0.0762191927925782 Inf 0.251727303473933 201.5 2233 False False Inf 1.22809956796298 Inf 0.00019193857965451 4.85945229729366e-06 0.00106894424519385 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Ethionamide ethA p.Thr203Pro ethA_p.Thr203Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1351 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Thr210Asn ethA_p.Thr210Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1296 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Thr210fs ethA_p.Thr210fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.55810577429468 Inf 0.0633939383341096 130.5 2233 False False Inf 0.55810577429468 Inf 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Thr232Ala ethA_p.Thr232Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 115.669966941234 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethionamide ethA p.Thr232fs ethA_p.Thr232fs 1 frameshift (see "Genomic_coordinates" sheet) 1 7 4 3 4 3 5208 15484 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.999806289145735 0.999434000080036 0.999960050383188 0.571428571428571 0.184051567640083 0.901011721557492 0.571428571428571 0.184051567640083 0.901011721557492 0.571428571428571 0.184051567640083 0.901011721557492 3.96415770609319 0.670342430404991 27.0684059834314 0.0721956912990955 145 2233 False False 3.96415770609319 0.670342430404991 27.0684059834314 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 4 0 4 0 2166 3790 0.00184331797235023 0.00050246332413509 0.00471284227984187 1 0.999027154404229 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 1.15374841388447 Inf 0.0175424291387373 30 1065 False False 0 0 0 0 0 0 0 Inf 1.15374841388447 Inf 0.00184331797235023 0.00050246332413509 0.00471284227984187 1 0.999027154404229 1 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Thr236fs ethA_p.Thr236fs 1 frameshift (see "Genomic_coordinates" sheet) 1 5 0 5 0 6 5212 15481 0 0 0.000707516179821284 0.99961257829147 0.999156938222445 0.999857810215121 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 3.2426835385054 0.339824258678335 348.5 2233 False False 0 0 2.52357746319564 0 0 0.000707516179821284 0.99961257829147 0.999156938222445 0.999857810215121 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 2170 3787 0 0 0.00169850036174098 0.999208443271767 0.997688494809834 0.999836732216022 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 9.29752209151186 0.536829969545164 228 1065 False False 0 0 0 0 0 0 0 0 0 4.22663965322398 0 0 0.00169850036174098 0.999208443271767 0.997688494809834 0.999836732216022 5 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Thr2Ala ethA_p.Thr2Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 115.699581334225 1 815 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Thr314Ala ethA_p.Thr314Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 3 1 7 1 5205 15486 0.00134305448963929 0.000540142673187124 0.00276523543039201 0.999935429715245 0.999640290494779 0.999998365223265 0.875 0.473490329124793 0.996840276468748 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 8.92564841498559 0.716402767320706 467.31722436766 0.0517002130996876 100 2233 False False 20.8265129682997 2.6743069562409 934.137954930732 0.000576036866359447 0.000118808407763576 0.00168249229256653 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 68.0751891811639 1 405 1065 False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 0 0 0.0016992827759538 0.999736147757256 0.998530795728906 0.999993319861894 2 3) Uncertain significance No change no 1 +Ethionamide ethA p.Thr314fs ethA_p.Thr314fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0762045661509476 Inf 0.251763455406319 213.5 2233 False False Inf 0.55810577429468 Inf 0.000191901746305891 4.8585197621771e-06 0.00106873920290263 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Thr314Ile ethA_p.Thr314Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 231 73 158 82 160 5130 15327 0.0157329240214888 0.0125319036989585 0.0194915488990575 0.989668754439207 0.987948576902692 0.991201059521977 0.338842975206611 0.279448755870335 0.402241453865435 0.316017316017316 0.256610538393103 0.380220239488953 0.313304721030042 0.254322108060812 0.3771122619214 1.38040195425272 1.02938810977983 1.83637226805335 0.0267884819798604 88 2233 False False 1.53120614035087 1.15641764575403 2.01462413320766 0.0140303670959062 0.0110132597567934 0.0176091617858142 0.989668754439207 0.987948576902692 0.991201059521977 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 180 64 116 72 118 2098 3672 0.0331797235023041 0.0260497742993271 0.0416036610986872 0.9688654353562 0.962829947114053 0.974162737939321 0.378947368421052 0.309718836103821 0.452016760215988 0.355555555555555 0.285760779515143 0.430195038585997 0.351648351648351 0.282470563734343 0.425746948803544 0.965648729496071 0.696843714312395 1.3281712769192 0.875066917580843 284 1065 False False 0 0 0 0 0 0 0 1.06794202711218 0.781315400655458 1.45135897762986 0.0296022201665124 0.0228703271057005 0.0376457129455948 0.9688654353562 0.962829947114053 0.974162737939321 135 3) Uncertain significance No change no 1 +Ethionamide ethA p.Thr316fs ethA_p.Thr316fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1394 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 691 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Thr321Pro ethA_p.Thr321Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 73 3 5139 15484 0.0140061396776669 0.0109942150585719 0.0175788097032655 0.999806289145735 0.999434000080036 0.999960050383188 0.960526315789473 0.888946680874036 0.991784407819405 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1366 2233 False False 73.3172471946552 24.1076073179322 362.130394783374 0 0 0.000717562909950718 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 7 0 2163 3790 0.0032258064516129 0.00129789474017921 0.00663503149939142 1 0.999027154404229 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 673 1065 False False 0 0 0 0 0 0 0 Inf 2.52187707425346 Inf 0 0 0.00170399244078473 1 0.999027154404229 1 28 3) Uncertain significance No change no 1 +Ethionamide ethA p.Thr323dup ethA_p.Thr323dup 1 inframe_insertion (see "Genomic_coordinates" sheet) 1 8 3 5 3 5 5209 15482 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.999677148576225 0.999246734667469 0.999895162977301 0.375 0.0852334141372535 0.755136783633448 0.375 0.0852334141372535 0.755136783633448 0.375 0.0852334141372535 0.755136783633448 1.78329813783835 0.27682812068913 9.16959691894064 0.424094458747099 371.5 2233 False False 1.78329813783835 0.27682812068913 9.16959691894064 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.999677148576225 0.999246734667469 0.999895162977301 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Ethionamide ethA p.Thr342Ala ethA_p.Thr342Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 3 1 4 1 5208 15486 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.999935429715245 0.999640290494779 0.999998365223265 0.8 0.28358206388191 0.994949236620532 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 8.92050691244239 0.715990228667412 467.048854197112 0.0517619162350058 104 2233 False False 11.8940092165898 1.17652678598182 583.885453446482 0.000575705238917674 0.00011874000007229 0.00168152420898675 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.74688796680497 0.0222439624669857 137.016358245527 1 405 1065 False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 5 3) Uncertain significance No change no 1 +Ethionamide ethA p.Thr342Lys ethA_p.Thr342Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 3 0 7 0 5205 15487 0.00134305448963929 0.000540142673187124 0.00276523543039201 1 0.999761836368682 1 1 0.590383602774996 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 1.22904298974233 Inf 0.0159304991505775 72 2233 False False Inf 4.28681262397718 Inf 0.000576036866359447 0.000118808407763576 0.00168249229256653 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 2 3) Uncertain significance No change no 1 +Ethionamide ethA p.Thr342Met ethA_p.Thr342Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 5212 15482 0 0 0.000707516179821284 0.999677148576225 0.999246734667469 0.999895162977301 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 4.50117892747928 0.578099153339956 468.5 2233 False False 0 0 3.24289311550326 0 0 0.000707516179821284 0.999677148576225 0.999246734667469 0.999895162977301 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 11 3) Uncertain significance No change no 1 +Ethionamide ethA p.Thr353fs ethA_p.Thr353fs 1 frameshift (see "Genomic_coordinates" sheet) 1 3 2 1 2 1 5210 15486 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 5.9447216890595 0.309382652589367 349.949104522224 0.158265844695452 166.5 2233 False False 5.9447216890595 0.309382652589367 349.949104522224 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Thr353Met ethA_p.Thr353Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Thr355fs ethA_p.Thr355fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1241 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 587 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Thr355Pro ethA_p.Thr355Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 1 2 5211 15485 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 1.48579927077336 0.0251793916671698 28.5526337681963 1 815 2233 False False 1.48579927077336 0.0251793916671698 28.5526337681963 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.74688796680497 0.0222439624669857 137.016358245527 1 405 1065 False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Thr364fs ethA_p.Thr364fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Thr365Met ethA_p.Thr365Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Thr366_Tyr369del ethA_p.Thr366_Tyr369del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Ethionamide ethA p.Thr366Pro ethA_p.Thr366Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1229 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Thr383Lys ethA_p.Thr383Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0762045661509476 Inf 0.251763455406319 213.5 2233 False False Inf 0.55810577429468 Inf 0.000191901746305891 4.8585197621771e-06 0.00106873920290263 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0448036218670314 Inf 0.363987246182245 113 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0.000461041954817888 1.16725035605811e-05 0.00256605588112533 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Thr383Pro ethA_p.Thr383Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 2 1 2 1 5210 15486 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 5.9447216890595 0.309382652589367 349.949104522224 0.158265844695452 166.5 2233 False False 5.9447216890595 0.309382652589367 349.949104522224 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Thr387fs ethA_p.Thr387fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Thr392Ala ethA_p.Thr392Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Thr392Arg ethA_p.Thr392Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 4 1 4 2 5208 15485 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.99987085943049 0.99953357854254 0.999984360095269 0.666666666666666 0.222778095503512 0.956728131707258 0.8 0.28358206388191 0.994949236620532 0.666666666666666 0.222778095503512 0.956728131707258 11.8932411674347 1.17645083549747 583.847887940772 0.0160422501957649 82 2233 False False 5.94662058371735 0.851897563491887 65.8224106582454 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 68.0259170395529 1 405 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Thr392Lys ethA_p.Thr392Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Thr392Met ethA_p.Thr392Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1252 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Thr392Pro ethA_p.Thr392Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1230 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 573 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0 0 0.00170006591133688 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Thr416fs ethA_p.Thr416fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Thr435Ile ethA_p.Thr435Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1216 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 563 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Thr44Ala ethA_p.Thr44Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 8 1 5204 15486 0.00153491941673062 0.000662894835129567 0.00302215107874993 0.999935429715245 0.999640290494779 0.999998365223265 0.888888888888888 0.517503485082663 0.9971908632534 0 0 0.975 0 0 0.975 0 0 115.854929329367 1 496.5 2233 False False 23.8063028439661 3.18975389486583 1050.70322780704 0 0 0.00070860344415093 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 2168 3789 0.000921658986175115 0.000111636674590768 0.0033253435449308 0.999736147757256 0.998530795728906 0.999993319861894 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 68.1065557614001 1 405 1065 False False 0 0 0 0 0 0 0 3.49538745387453 0.181825522231654 206.012215468794 0 0 0.00170006591133688 0.999736147757256 0.998530795728906 0.999993319861894 3 3) Uncertain significance No change no 1 +Ethionamide ethA p.Thr44fs ethA_p.Thr44fs 1 frameshift (see "Genomic_coordinates" sheet) 1 3 2 1 2 1 5210 15486 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 5.9447216890595 0.309382652589367 349.949104522224 0.158265844695452 166.5 2233 False False 5.9447216890595 0.309382652589367 349.949104522224 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Thr44Ile ethA_p.Thr44Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Thr44Pro ethA_p.Thr44Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 2.97179044329303 0.0378514560716107 232.854636669753 0.440205269357083 400.5 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 2 3) Uncertain significance No change no 1 +Ethionamide ethA p.Thr453Arg ethA_p.Thr453Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1208 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Thr453Ile ethA_p.Thr453Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 59 2 57 19 64 5193 15423 0.00364543361473522 0.00219617244689937 0.00568696754173622 0.995867501775682 0.994725913994443 0.996816061984566 0.228915662650602 0.143803601998439 0.334169932268945 0.0338983050847457 0.00413193297236521 0.117148463888393 0.0303030303030303 0.00369113896142986 0.105216648579651 0.104209107401664 0.0123193169905639 0.394369724184307 1.38060850025581e-05 27 2233 True False 0.881706744656268 0.498357155344023 1.49228128835627 0.000384985563041385 4.66269386801633e-05 0.00139000107666266 0.995867501775682 0.994725913994443 0.996816061984566 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 4 3) Uncertain significance No change no 1 +Ethionamide ethA p.Thr453Ser ethA_p.Thr453Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Ethionamide ethA p.Thr61Ala ethA_p.Thr61Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 2 5208 15485 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.99987085943049 0.99953357854254 0.999984360095269 0.666666666666666 0.222778095503512 0.956728131707258 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1385 2233 False False 5.94662058371735 0.851897563491887 65.8224106582454 0 0 0.000708059394597755 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 684 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 3 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Thr61Arg ethA_p.Thr61Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 5 4 5207 15483 0.000959324635456638 0.000311561141138009 0.0022373118395626 0.99974171886098 0.999338830952079 0.999929622742193 0.555555555555555 0.212008506778868 0.863004337734833 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1271 2233 False False 3.71687151910889 0.799617579523072 18.7336165793798 0 0 0.00070819532865061 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 4 3 1 3 1 2167 3789 0.00138248847926267 0.000285193152965682 0.0040348522148252 0.999736147757256 0.998530795728906 0.999993319861894 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 5.2455006922012 0.420751345257316 275.029142692281 0.140266575766913 67.5 1065 False False 0 0 0 0 0 0 0 5.2455006922012 0.420751345257316 275.029142692281 0.00138248847926267 0.000285193152965682 0.0040348522148252 0.999736147757256 0.998530795728906 0.999993319861894 2 3) Uncertain significance No change no 1 +Ethionamide ethA p.Thr61fs ethA_p.Thr61fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 2 5211 15485 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1372 2233 False False 1.48579927077336 0.0251793916671698 28.5526337681963 0 0 0.000707651905360176 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Thr61Lys ethA_p.Thr61Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Thr61Met ethA_p.Thr61Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 33 13 20 18 20 5194 15467 0.00345356868764389 0.00204804863805522 0.00545265611077246 0.9987085943049 0.998006229813624 0.999211003011252 0.473684210526315 0.309807301608208 0.641816563739496 0.393939393939393 0.2290662383642 0.578606278611749 0.393939393939393 0.2290662383642 0.578606278611749 1.93560839430111 0.884121357368333 4.09228738723377 0.0701137305851422 144 2233 False False 2.68007316134 1.33545259249512 5.34107078997303 0.00249663913961974 0.00133000404396326 0.00426554490997107 0.9987085943049 0.998006229813624 0.999211003011252 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 23 11 12 12 12 2158 3778 0.00552995391705069 0.00286057468269438 0.00963977234551449 0.996833773087071 0.994475777251357 0.998362927167916 0.5 0.291241779836211 0.708758220163788 0.478260869565217 0.268196186175553 0.694121998508626 0.478260869565217 0.268196186175553 0.694121998508626 1.60480383070744 0.640353135710747 3.97981851204238 0.280492648773873 82 1065 False False 0 0 0 0 0 0 0 1.75069508804448 0.717934134021309 4.26823464565486 0.00507146150299677 0.00253429198602114 0.00905608733862772 0.996833773087071 0.994475777251357 0.998362927167916 3 3) Uncertain significance No change no 1 +Ethionamide ethA p.Thr70Ser ethA_p.Thr70Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 0 9 0 12 5212 15475 0 0 0.000707516179821284 0.99922515658294 0.998646896080726 0.999599565042795 0 0 0.264648469397051 0 0 0.336267116879942 0 0 0.264648469397051 0 0 1.50490315959337 0.123736379423943 155 2233 False False 0 0 1.06903209420596 0 0 0.000707516179821284 0.99922515658294 0.998646896080726 0.999599565042795 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.2999762698034 0.53686319604546 244.5 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 15 3) Uncertain significance No change no 1 +Ethionamide ethA p.Thr88fs ethA_p.Thr88fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 4 5211 15483 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99974171886098 0.999338830952079 0.999929622742193 0.2 0.00505076337946806 0.716417936118089 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1343 2233 False False 0.742803684513529 0.0150842538989179 7.50989306640636 0 0 0.000707651905360176 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Thr88Ile ethA_p.Thr88Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 8 1 9 1 5203 15486 0.00172678434382194 0.000789890217063144 0.00327543249467561 0.999935429715245 0.999640290494779 0.999998365223265 0.9 0.554983882971804 0.997471421455538 0.888888888888888 0.517503485082663 0.9971908632534 0.888888888888888 0.517503485082663 0.9971908632534 23.8108783394195 3.19036422075101 1050.90394264712 0.000112346659412399 34 2233 True False 26.787238131847 3.71007179833019 1167.16985789294 0.00153521397044713 0.00066302208912997 0.00302273060262302 0.999935429715245 0.999640290494779 0.999998365223265 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance 1 7 7 0 7 0 2163 3790 0.0032258064516129 0.00129789474017921 0.00663503149939142 1 0.999027154404229 1 1 0.590383602774996 1 1 0.590383602774996 1 1 0.590383602774996 1 Inf 2.52187707425346 Inf 0.000842981522069308 17 1065 False False 0 0 0 0 0 0 0 Inf 2.52187707425346 Inf 0.0032258064516129 0.00129789474017921 0.00663503149939142 1 0.999027154404229 1 6 Assoc w RI Evidence from ALL dataset only 2) Assoc w R - Interim No change yes ALL only 1 +Ethionamide ethA p.Thr88Pro ethA_p.Thr88Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 5209 15487 0.000575594781273983 0.000118717215010897 0.00168120176197813 1 0.999761836368682 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1373 2233 False False Inf 1.22809956796298 Inf 0 0 0.000707923512718415 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Trp109Cys ethA_p.Trp109Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 2.97179044329303 0.0378514560716107 232.854636669753 0.440205269357083 400.5 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Trp109* ethA_p.Trp109* 1 stop_gained (see "Genomic_coordinates" sheet) 1 4 3 1 6 1 5206 15486 0.00115118956254796 0.000422579736688136 0.00250395844332671 0.999935429715245 0.999640290494779 0.999998365223265 0.857142857142857 0.421276802956804 0.996389703138099 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 8.92393392239723 0.716265201624059 467.227733386763 0.051720777882815 101.5 2233 False False 17.8478678447944 2.16423442406627 817.47760823406 0.000575926281435976 0.000118785596443588 0.00168216947420971 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 3 0 4 0 2166 3790 0.00184331797235023 0.00050246332413509 0.00471284227984187 1 0.999027154404229 1 1 0.397635364383525 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.722324838220065 Inf 0.0481810496160712 34 1065 False False 0 0 0 0 0 0 0 Inf 1.15374841388447 Inf 0.00138312586445366 0.000285324680875951 0.00403670997741914 1 0.999027154404229 1 1 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Trp116_Cys137del ethA_p.Trp116_Cys137del 1 inframe_deletion (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1266 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Ethionamide ethA p.Trp116Cys ethA_p.Trp116Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1403 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethionamide ethA p.Trp116Ser ethA_p.Trp116Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Trp116* ethA_p.Trp116* 1 stop_gained (see "Genomic_coordinates" sheet) 1 2 1 1 2 7 5210 15480 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999548008006715 0.999068946905294 0.99981825708278 0.222222222222222 0.0281449734778982 0.600093573716312 0.5 0.012579117093425 0.987420882906574 0.125 0.0031597235312519 0.526509670875206 2.97120921305182 0.0378440515799828 232.809192166842 0.440260421348274 420 2233 False False 0.848916918014806 0.0860206666092397 4.46043370684753 0.000191901746305891 4.8585197621771e-06 0.00106873920290263 0.999548008006715 0.999068946905294 0.99981825708278 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 6 2168 3784 0.000921658986175115 0.000111636674590768 0.0033253435449308 0.998416886543535 0.996557436795264 0.999418810659556 0.25 0.0318540262499442 0.650855794412824 1 0.025 1 0.142857142857142 0.00361029686190058 0.578723197043195 Inf 0.0447326919906046 Inf 0.364354107172854 214 1065 False False 0 0 0 0 0 0 0 0.581795817958179 0.0573643286211511 3.25769068238809 0.000461041954817888 1.16725035605811e-05 0.00256605588112533 0.998416886543535 0.996557436795264 0.999418810659556 2 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Trp167Arg ethA_p.Trp167Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 3 1 3 1 5209 15486 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.999935429715245 0.999640290494779 0.999998365223265 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 8.91879439431752 0.715852821346612 466.959465949029 0.0517824898023508 107.5 2233 False False 8.91879439431752 0.715852821346612 466.959465949029 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 3 1 3 1 2167 3789 0.00138248847926267 0.000285193152965682 0.0040348522148252 0.999736147757256 0.998530795728906 0.999993319861894 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 5.2455006922012 0.420751345257316 275.029142692281 0.140266575766913 67.5 1065 False False 0 0 0 0 0 0 0 5.2455006922012 0.420751345257316 275.029142692281 0.00138248847926267 0.000285193152965682 0.0040348522148252 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Trp167Cys ethA_p.Trp167Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 115.662511114998 1 815 2233 False False 0 0 7.19247409791798 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Trp167fs ethA_p.Trp167fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Trp167Gly ethA_p.Trp167Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.55810577429468 Inf 0.0633939383341096 130.5 2233 False False Inf 0.55810577429468 Inf 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 2 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Trp167Ser ethA_p.Trp167Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1277 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethionamide ethA p.Trp167* ethA_p.Trp167* 1 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1344 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Trp21Arg ethA_p.Trp21Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 1 2 5211 15485 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 1.48579927077336 0.0251793916671698 28.5526337681963 1 815 2233 False False 1.48579927077336 0.0251793916671698 28.5526337681963 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Trp21fs ethA_p.Trp21fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Trp21Gly ethA_p.Trp21Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Trp21Leu ethA_p.Trp21Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Trp21* ethA_p.Trp21* 1 stop_gained (see "Genomic_coordinates" sheet) 1 3 1 2 2 3 5210 15484 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999806289145735 0.999434000080036 0.999960050383188 0.4 0.0527449505263169 0.853367200365326 0.333333333333333 0.00840375865961264 0.905700675949754 0.25 0.00630946320970987 0.805879550316756 1.48598848368522 0.0251825973021435 28.5562583562758 1 815 2233 False False 1.98131797824696 0.165426255296508 17.2953159846476 0.000191901746305891 4.8585197621771e-06 0.00106873920290263 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 2170 3787 0 0 0.00169850036174098 0.999208443271767 0.997688494809834 0.999836732216022 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 9.29752209151186 0.536829969545164 228 1065 False False 0 0 0 0 0 0 0 0 0 4.22663965322398 0 0 0.00169850036174098 0.999208443271767 0.997688494809834 0.999836732216022 10 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Trp228fs ethA_p.Trp228fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1320 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Trp228* ethA_p.Trp228* 1 stop_gained (see "Genomic_coordinates" sheet) 1 3 2 1 3 1 5209 15486 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.999935429715245 0.999640290494779 0.999998365223265 0.75 0.194120449683243 0.99369053679029 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 5.94586292954501 0.309442031422125 350.016117394062 0.158224983853206 160.5 2233 False False 8.91879439431752 0.715852821346612 466.959465949029 0.000383803492611782 4.64837636131093e-05 0.00138573531807565 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0448036218670314 Inf 0.363987246182245 113 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0.000461041954817888 1.16725035605811e-05 0.00256605588112533 1 0.999027154404229 1 NA Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Trp240Arg ethA_p.Trp240Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 2 2 5210 15485 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.99987085943049 0.99953357854254 0.999984360095269 0.5 0.067585986488543 0.932414013511457 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8293686688623 1 815 2233 False False 2.97216890595009 0.215371636513233 40.9716636776753 0 0 0.000707787682982558 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Trp240* ethA_p.Trp240* 1 stop_gained (see "Genomic_coordinates" sheet) 1 3 1 2 2 2 5210 15485 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.99987085943049 0.99953357854254 0.999984360095269 0.5 0.067585986488543 0.932414013511457 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 1.48608445297504 0.0251842236737227 28.558096294943 1 815 2233 False False 2.97216890595009 0.215371636513233 40.9716636776753 0.000191901746305891 4.8585197621771e-06 0.00106873920290263 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 2 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Trp256fs ethA_p.Trp256fs 1 frameshift (see "Genomic_coordinates" sheet) 2 1 0 1 96 27 5116 15460 0.0184190330007674 0.0149442957380114 0.0224468331758866 0.998256602311616 0.997464453982962 0.998850785332127 0.780487804878048 0.696924540084783 0.850080297983555 0 0 0.975 0 0 0.127702867615432 0 0 117.646597233063 1 815 2233 False False 10.7445052558422 6.93861984652311 17.1573400492676 0 0 0.000720787694466269 0.998256602311616 0.997464453982962 0.998850785332127 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 62 21 2108 3769 0.0285714285714285 0.0219741643482138 0.0364791223913734 0.994459102902374 0.991542558159884 0.996566923060264 0.746987951807228 0.639611496021706 0.83605748487725 NA NA NA 0 0 0.161097615219079 NA NA NA NA 674 1065 False False 0 0 0 0 0 0 0 5.27871148459383 3.16187352074523 9.14056434554062 0 0 0.0017484125578676 0.994459102902374 0.991542558159884 0.996566923060264 91 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Trp256Gly ethA_p.Trp256Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Trp256* ethA_p.Trp256* 1 stop_gained (see "Genomic_coordinates" sheet) 1 29 12 17 13 17 5199 15470 0.00249424405218726 0.00132872751584936 0.0042614564942691 0.998902305159165 0.998243064068552 0.999360426383401 0.433333333333333 0.254607549903263 0.625726549390779 0.413793103448275 0.235240209752898 0.610637208603093 0.413793103448275 0.235240209752898 0.610637208603093 2.1004039238315 0.914573445072702 4.67050903440913 0.0534974379576479 110 2233 False False 2.27543758415079 1.01559896702405 4.97786671637006 0.00230282095567069 0.00119044964985482 0.00401910602431561 0.998902305159165 0.998243064068552 0.999360426383401 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 23 11 12 11 12 2159 3778 0.00506912442396313 0.00253312289257636 0.00905192238910812 0.996833773087071 0.994475777251357 0.998362927167916 0.478260869565217 0.268196186175553 0.694121998508626 0.478260869565217 0.268196186175553 0.694121998508626 0.478260869565217 0.268196186175553 0.694121998508626 1.60406052184653 0.640056953728697 3.97797021735549 0.280588996816 83 1065 False False 0 0 0 0 0 0 0 1.60406052184653 0.640056953728697 3.97797021735549 0.00506912442396313 0.00253312289257636 0.00905192238910812 0.996833773087071 0.994475777251357 0.998362927167916 23 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Trp289Arg ethA_p.Trp289Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 2.97179044329303 0.0378514560716107 232.854636669753 0.440205269357083 400.5 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Trp289fs ethA_p.Trp289fs 1 frameshift (see "Genomic_coordinates" sheet) 1 10 5 5 7 5 5205 15482 0.00134305448963929 0.000540142673187124 0.00276523543039201 0.999677148576225 0.999246734667469 0.999895162977301 0.583333333333333 0.276669685682105 0.848347770191569 0.5 0.187086028447398 0.812913971552601 0.5 0.187086028447398 0.812913971552601 2.97444764649375 0.68419654698095 12.9257932618788 0.135100589172955 157 2233 False False 4.16422670509125 1.13705438665461 16.6495349842184 0.000959692898272552 0.000311680769637036 0.00223817014272861 0.999677148576225 0.999246734667469 0.999895162977301 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 2170 3786 0 0 0.00169850036174098 0.998944591029023 0.997299958285064 0.999712364080324 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.6454264678615 0.303692649321994 95 1065 False False 0 0 0 0 0 0 0 0 0 2.6454264678615 0 0 0.00169850036174098 0.998944591029023 0.997299958285064 0.999712364080324 9 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Trp289* ethA_p.Trp289* 1 stop_gained (see "Genomic_coordinates" sheet) 1 5 3 2 5 3 5207 15484 0.000959324635456638 0.000311561141138009 0.0022373118395626 0.999806289145735 0.999434000080036 0.999960050383188 0.625 0.244863216366551 0.914766585862746 0.6 0.146632799634673 0.947255049473683 0.5 0.118117248757025 0.881882751242974 4.46053389667755 0.510763849533038 53.3863175971526 0.10533318060151 148 2233 False False 4.95614877408616 0.963790796814113 31.9243794332185 0.000575815738963531 0.000118762793881507 0.00168184677970687 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.74688796680497 0.0222439624669857 137.016358245527 1 405 1065 False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 1 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Trp391Arg ethA_p.Trp391Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1184 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Trp391Cys ethA_p.Trp391Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1231 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 574 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0 0 0.00170006591133688 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Trp391* ethA_p.Trp391* 1 stop_gained (see "Genomic_coordinates" sheet) 1 24 11 13 14 21 5198 15466 0.00268610897927858 0.00146927470920863 0.00450273151667691 0.998644024020146 0.997927989586209 0.999160439688496 0.4 0.238708110453341 0.5788822781179 0.458333333333333 0.255530201994746 0.671791924304822 0.34375 0.185719091716566 0.531931036280268 2.51762512208837 1.02054224474254 6.09401424098759 0.0309806073240597 91 2233 False False 1.98358342952417 0.932176381641486 4.09342534232999 0.00211172969859857 0.00105462447711498 0.00377531910668231 0.998644024020146 0.997927989586209 0.999160439688496 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 16 9 7 10 11 2160 3779 0.00460829493087557 0.00221200142499431 0.00845843813305835 0.997097625329815 0.994812797611582 0.998550282198211 0.476190476190476 0.257130626406406 0.702193161216357 0.5625 0.298776899083177 0.802465859467332 0.45 0.230577896775924 0.684721866959451 2.24940476190476 0.744117952361272 7.11794974825007 0.119497833529821 51 1065 False False 0 0 0 0 0 0 0 1.59048821548821 0.604417671688508 4.13236255706347 0.00414937759336099 0.00189906157648759 0.00786213528990298 0.997097625329815 0.994812797611582 0.998550282198211 14 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Trp455Arg ethA_p.Trp455Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 5211 15485 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8263323782973 1 815 2233 False False 1.48579927077336 0.0251793916671698 28.5526337681963 0 0 0.000707651905360176 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 699 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Trp455* ethA_p.Trp455* 1 stop_gained (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 2.97179044329303 0.0378514560716107 232.854636669753 0.440205269357083 400.5 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 3 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Trp45fs ethA_p.Trp45fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1217 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Trp45Gly ethA_p.Trp45Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Trp45Leu ethA_p.Trp45Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1308 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Trp45* ethA_p.Trp45* 1 stop_gained (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 2.97179044329303 0.0378514560716107 232.854636669753 0.440205269357083 400.5 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Trp69Arg ethA_p.Trp69Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 5211 15485 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 115.692124084117 1 815 2233 False False 1.48579927077336 0.0251793916671698 28.5526337681963 0 0 0.000707651905360176 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 2169 3788 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999472295514512 0.998095063429584 0.999936086148442 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 68.0572464902929 1 405 1065 False False 0 0 0 0 0 0 0 0.87321346242508 0.0147995228023146 16.7833115850342 0 0 0.0016992827759538 0.999472295514512 0.998095063429584 0.999936086148442 6 3) Uncertain significance No change no 1 +Ethionamide ethA p.Trp69fs ethA_p.Trp69fs 1 frameshift (see "Genomic_coordinates" sheet) 1 3 1 2 1 2 5211 15485 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 1.48579927077336 0.0251793916671698 28.5526337681963 1 815 2233 False False 1.48579927077336 0.0251793916671698 28.5526337681963 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Trp69Leu ethA_p.Trp69Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Trp69Ser ethA_p.Trp69Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Trp69* ethA_p.Trp69* 1 stop_gained (see "Genomic_coordinates" sheet) 1 2 1 1 6 3 5206 15484 0.00115118956254796 0.000422579736688136 0.00250395844332671 0.999806289145735 0.999434000080036 0.999960050383188 0.666666666666666 0.29929505620854 0.925145368580308 0.5 0.012579117093425 0.987420882906574 0.25 0.00630946320970987 0.805879550316756 2.97426046868997 0.0378829097782348 233.047785362118 0.439971122219861 376 2233 False False 5.94852093737994 1.26973821980427 36.7666540443382 0.000192049164586134 4.86225205174921e-06 0.00106955984439844 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Tyr140* ethA_p.Tyr140* 1 stop_gained (see "Genomic_coordinates" sheet) 1 24 9 15 9 16 5203 15471 0.00172678434382194 0.000789890217063144 0.00327543249467561 0.99896687544392 0.998322811196946 0.999409368388177 0.36 0.179716820583655 0.57479365044615 0.375 0.187992928196002 0.594063615992055 0.36 0.179716820583655 0.57479365044615 1.78408610417067 0.68795095190252 4.35436322088705 0.163697517949644 175 2233 False False 1.67258072266 0.651028618733017 4.02212713652417 0.00172678434382194 0.000789890217063144 0.00327543249467561 0.99896687544392 0.998322811196946 0.999409368388177 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 5 5 5 5 2165 3785 0.00230414746543778 0.000748560476988087 0.00536885389822181 0.998680738786279 0.996923992057454 0.999571505100005 0.5 0.187086028447398 0.812913971552601 0.5 0.187086028447398 0.812913971552601 0.5 0.187086028447398 0.812913971552601 1.74826789838337 0.401816597175933 7.6048231979945 0.512080802277625 225 1065 False False 0 0 0 0 0 0 0 1.74826789838337 0.401816597175933 7.6048231979945 0.00230414746543778 0.000748560476988087 0.00536885389822181 0.998680738786279 0.996923992057454 0.999571505100005 24 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Tyr141Asn ethA_p.Tyr141Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1198 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 551 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Tyr141Cys ethA_p.Tyr141Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 115.662511114998 1 815 2233 False False 0 0 7.19247409791798 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 652 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 10 3) Uncertain significance No change no 1 +Ethionamide ethA p.Tyr143* ethA_p.Tyr143* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 115.669966941234 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 68.0259170395529 1 405 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 3 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Tyr147Cys ethA_p.Tyr147Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1286 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 615 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 4 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Tyr147fs ethA_p.Tyr147fs 1 frameshift (see "Genomic_coordinates" sheet) 1 7 1 6 1 6 5211 15481 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99961257829147 0.999156938222445 0.999857810215121 0.142857142857142 0.00361029686190058 0.578723197043195 0.142857142857142 0.00361029686190058 0.578723197043195 0.142857142857142 0.00361029686190058 0.578723197043195 0.495138489093584 0.0107661625367428 4.08269117192464 0.687754693812012 476 2233 False False 0.495138489093584 0.0107661625367428 4.08269117192464 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99961257829147 0.999156938222445 0.999857810215121 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 1 6 1 6 2169 3784 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.998416886543535 0.996557436795264 0.999418810659556 0.142857142857142 0.00361029686190058 0.578723197043195 0.142857142857142 0.00361029686190058 0.578723197043195 0.142857142857142 0.00361029686190058 0.578723197043195 0.29076379283848097 0.00632256517654589 2.39937940259791 0.434011985866556 219.5 1065 False False 0 0 0 0 0 0 0 0.29076379283848097 0.00632256517654589 2.39937940259791 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.998416886543535 0.996557436795264 0.999418810659556 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Tyr147Ser ethA_p.Tyr147Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 5210 15486 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 115.721748393509 1 815 2233 False False 5.9447216890595 0.309382652589367 349.949104522224 0 0 0.000707787682982558 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Tyr147* ethA_p.Tyr147* 1 stop_gained (see "Genomic_coordinates" sheet) 1 54 25 29 29 30 5183 15457 0.0055640828856485 0.00372942630839521 0.00798124971230584 0.998062891457351 0.997235802492176 0.998692671150172 0.491525423728813 0.358912727800532 0.625017450265023 0.462962962962962 0.326224630104279 0.603905044279291 0.454545454545454 0.319700679995166 0.594455108842661 2.57090488134285 1.44234502416208 4.55106063545707 0.000783160678142084 39 2233 True False 2.88284134027911 1.66778131841837 4.9757473326699 0.00480030721966205 0.00310884248393203 0.00707809823808947 0.998062891457351 0.997235802492176 0.998692671150172 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance 1 44 23 21 24 22 2146 3768 0.0110599078341013 0.00709878868381528 0.0164118279598698 0.99419525065963 0.991224655744321 0.996358725497634 0.521739130434782 0.369456473569983 0.671121313072659 0.522727272727272 0.366897516592834 0.675385783602917 0.511111111111111 0.35774038567003 0.662966251607206 1.92304619890826 1.01476234939423 3.66216871185728 0.0395612880763378 33 1065 False False 0 0 0 0 0 0 0 1.91544522579005 1.02593264366396 3.59212640267631 0.0106039649608114 0.00673354701679672 0.0158689011363244 0.99419525065963 0.991224655744321 0.996358725497634 17 Assoc w RI Evidence from ALL dataset only 2) Assoc w R - Interim No change no ALL only 1 +Ethionamide ethA p.Tyr211Asp ethA_p.Tyr211Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 7.19247409791798 0.577090863007554 439 2233 False False 0 0 7.19247409791798 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Tyr211Cys ethA_p.Tyr211Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 5 2 6 5 5206 15482 0.00115118956254796 0.000422579736688136 0.00250395844332671 0.999677148576225 0.999246734667469 0.999895162977301 0.545454545454545 0.233793597659345 0.832511905936292 0.714285714285714 0.290420863737342 0.963307433823914 0.5 0.187086028447398 0.812913971552601 7.43469074145217 1.21657940903884 78.0024100299074 0.0132844888604308 70 2233 False False 3.56865155589704 0.906955013469831 14.792736256713 0.000959508731529456 0.000311620943906444 0.0022377409088434 0.999677148576225 0.999246734667469 0.999895162977301 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 4 1 4 2 2166 3788 0.00184331797235023 0.00050246332413509 0.00471284227984187 0.999472295514512 0.998095063429584 0.999936086148442 0.666666666666666 0.222778095503512 0.956728131707258 0.8 0.28358206388191 0.994949236620532 0.666666666666666 0.222778095503512 0.956728131707258 6.99538319482917 0.691492220802566 343.975768113399 0.0622312237805871 43 1065 False False 0 0 0 0 0 0 0 3.49769159741458 0.50070237346979 38.6880977910277 0.00184331797235023 0.00050246332413509 0.00471284227984187 0.999472295514512 0.998095063429584 0.999936086148442 4 3) Uncertain significance No change no 1 +Ethionamide ethA p.Tyr211fs ethA_p.Tyr211fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.55810577429468 Inf 0.0633939383341096 130.5 2233 False False Inf 0.55810577429468 Inf 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Tyr211His ethA_p.Tyr211His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 5210 15486 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 115.721748393509 1 815 2233 False False 5.9447216890595 0.309382652589367 349.949104522224 0 0 0.000707787682982558 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 645 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Tyr211Ser ethA_p.Tyr211Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 3 1 14 1 5198 15486 0.00268610897927858 0.00146927470920863 0.00450273151667691 0.999935429715245 0.999640290494779 0.999998365223265 0.933333333333333 0.680515433421696 0.998313569758647 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 8.9376683339746 0.717367208782715 467.944622279906 0.0515563417000731 99 2233 False False 41.7091188918814 6.34067510635841 1747.90139214907 0.000576812151509325 0.00011896833264925 0.00168475549497333 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 5 1 2165 3789 0.00230414746543778 0.000748560476988087 0.00536885389822181 0.999736147757256 0.998530795728906 0.999993319861894 0.833333333333333 0.358765421002325 0.99578925548551 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.7501154734411 0.022285041521953 137.269215743195 1 405 1065 False False 0 0 0 0 0 0 0 8.75057736720554 0.977928811939725 413.123713213578 0.000461680517082179 1.16886703685344e-05 0.00256960622502152 0.999736147757256 0.998530795728906 0.999993319861894 45 3) Uncertain significance No change no 1 +Ethionamide ethA p.Tyr211* ethA_p.Tyr211* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0762045661509476 Inf 0.251763455406319 213.5 2233 False False Inf 0.55810577429468 Inf 0.000191901746305891 4.8585197621771e-06 0.00106873920290263 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Tyr235Asp ethA_p.Tyr235Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1395 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Tyr235fs ethA_p.Tyr235fs 1 frameshift (see "Genomic_coordinates" sheet) 1 35 24 11 26 11 5186 15476 0.00498848810437452 0.00326115646340474 0.00730080572483271 0.999289726867695 0.998729481387772 0.999645382583254 0.702702702702702 0.530200465005933 0.841274563620371 0.685714285714285 0.507119999684825 0.831482849252997 0.685714285714285 0.507119999684825 0.831482849252997 6.51095607053956 3.06742292000986 14.7313338674029 8.18456041990633e-08 19 2233 True False 7.05353574308452 3.36468947461049 15.8202985102626 0.00460652591170825 0.00295365088506213 0.0068464400508823 0.999289726867695 0.998729481387772 0.999645382583254 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 31 23 8 25 8 2145 3782 0.0115207373271889 0.00746910666734498 0.0169601879423384 0.997889182058047 0.995845105987758 0.999088271930771 0.757575757575757 0.577410682288298 0.88907670044116 0.741935483870967 0.553866065665103 0.881436004170448 0.741935483870967 0.553866065665103 0.881436004170448 5.06911421911421 2.18362053578292 13.1297779385728 3.43742272688654e-05 10 1065 True False 0 0 0 0 0 0 0 5.50990675990676 2.40317614469194 14.1591107785938 0.0106088560885608 0.0067366582440197 0.0158762012274045 0.997889182058047 0.995845105987758 0.999088271930771 38 1) Assoc w R UP from AwRI to AwR yes 4 +Ethionamide ethA p.Tyr235His ethA_p.Tyr235His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1236 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 579 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Tyr250Asn ethA_p.Tyr250Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Tyr250* ethA_p.Tyr250* 1 stop_gained (see "Genomic_coordinates" sheet) 1 11 4 7 6 7 5206 15480 0.00115118956254796 0.000422579736688136 0.00250395844332671 0.999548008006715 0.999068946905294 0.99981825708278 0.461538461538461 0.192232441801288 0.748654517729696 0.363636363636363 0.109263443819098 0.692095284988322 0.363636363636363 0.109263443819098 0.692095284988322 1.699138356841 0.364589516493497 6.68598018741086 0.484910130162881 424 2233 False False 2.54870753526151 0.707250576895684 8.86020387579576 0.000767754318618042 0.00020922557096599 0.00196457876257061 0.999548008006715 0.999068946905294 0.99981825708278 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Tyr276Asp ethA_p.Tyr276Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 9 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Tyr276fs ethA_p.Tyr276fs 1 frameshift (see "Genomic_coordinates" sheet) 1 18 11 7 13 8 5199 15479 0.00249424405218726 0.00132872751584936 0.0042614564942691 0.99948343772196 0.998982421476308 0.999776959534822 0.619047619047619 0.384354390378645 0.818928374459826 0.611111111111111 0.357451205893062 0.827014145210248 0.578947368421052 0.334997844011735 0.797478561022837 4.67861951474184 1.65513023829692 14.2419800368659 0.00131710752636822 45 2233 False False 4.83811790728986 1.85744653498917 13.4740068146541 0.00211132437619961 0.00105442196629094 0.00377459508148457 0.99948343772196 0.998982421476308 0.999776959534822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 6 1 7 1 2163 3789 0.0032258064516129 0.00129789474017921 0.00663503149939142 0.999736147757256 0.998530795728906 0.999993319861894 0.875 0.473490329124793 0.996840276468748 0.857142857142857 0.421276802956804 0.996389703138099 0.857142857142857 0.421276802956804 0.996389703138099 10.51040221914 1.27342756776332 482.423341276488 0.0111594979508375 25 1065 False False 0 0 0 0 0 0 0 12.26213592233 1.57306574336124 551.297896238784 0.00276625172890733 0.00101582118509206 0.00601117166233729 0.999736147757256 0.998530795728906 0.999993319861894 13 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Tyr276His ethA_p.Tyr276His 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 4 2 5208 15485 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.99987085943049 0.99953357854254 0.999984360095269 0.666666666666666 0.222778095503512 0.956728131707258 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8354447515761 1 815 2233 False False 5.94662058371735 0.851897563491887 65.8224106582454 0 0 0.000708059394597755 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 692 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0 0 0.00170006591133688 1 0.999027154404229 1 20 3) Uncertain significance No change no 1 +Ethionamide ethA p.Tyr276* ethA_p.Tyr276* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Tyr286Cys ethA_p.Tyr286Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1278 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Tyr32Asp ethA_p.Tyr32Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 27 13 14 15 14 5197 15473 0.00287797390636991 0.0016116471700824 0.00474234467149281 0.99909601601343 0.998483733164878 0.999505698211522 0.517241379310344 0.325314996361456 0.705514417048159 0.481481481481481 0.286672548131939 0.680503453866616 0.481481481481481 0.286672548131939 0.680503453866616 2.76463069353198 1.1955845152924 6.34553942136803 0.012221702522055 68 2233 False False 3.1899584925369 1.43438939085257 7.13714587238961 0.00249520153550863 0.00132923783293336 0.00426309091971586 0.99909601601343 0.998483733164878 0.999505698211522 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 Assoc w RI 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Ethionamide ethA p.Tyr32dup ethA_p.Tyr32dup 1 inframe_insertion (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Ethionamide ethA p.Tyr32fs ethA_p.Tyr32fs 1 frameshift (see "Genomic_coordinates" sheet) 1 6 3 3 3 3 5209 15484 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.999806289145735 0.999434000080036 0.999960050383188 0.5 0.118117248757025 0.881882751242974 0.5 0.118117248757025 0.881882751242974 0.5 0.118117248757025 0.881882751242974 2.97254751391821 0.397987980392264 22.1986618481397 0.17226231092427 179 2233 False False 2.97254751391821 0.397987980392264 22.1986618481397 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Tyr32* ethA_p.Tyr32* 1 stop_gained (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 2.97179044329303 0.0378514560716107 232.854636669753 0.440205269357083 400.5 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Tyr369Asp ethA_p.Tyr369Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1357 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Tyr369Cys ethA_p.Tyr369Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 3 0 5209 15487 0.000575594781273983 0.000118717215010897 0.00168120176197813 1 0.999761836368682 1 1 0.292401773821286 1 1 0.025 1 1 0.025 1 Inf 0.0762191927925782 Inf 0.251727303473933 201.5 2233 False False Inf 1.22809956796298 Inf 0.00019193857965451 4.85945229729366e-06 0.00106894424519385 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Tyr369fs ethA_p.Tyr369fs 1 frameshift (see "Genomic_coordinates" sheet) 1 5 5 0 7 0 5205 15487 0.00134305448963929 0.000540142673187124 0.00276523543039201 1 0.999761836368682 1 1 0.590383602774996 1 1 0.478176249895018 1 1 0.478176249895018 1 Inf 2.72532432300889 Inf 0.00100931714167107 42 2233 False False Inf 4.28681262397718 Inf 0.000959692898272552 0.000311680769637036 0.00223817014272861 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Tyr369* ethA_p.Tyr369* 1 stop_gained (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1336 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 657 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Tyr382Asn ethA_p.Tyr382Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1337 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Tyr382His ethA_p.Tyr382His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Tyr382* ethA_p.Tyr382* 1 stop_gained (see "Genomic_coordinates" sheet) 1 4 2 2 2 2 5210 15485 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.99987085943049 0.99953357854254 0.999984360095269 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 2.97216890595009 0.215371636513233 40.9716636776753 0.264749199588554 341 2233 False False 2.97216890595009 0.215371636513233 40.9716636776753 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Tyr386Cys ethA_p.Tyr386Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1199 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Tyr386fs ethA_p.Tyr386fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Tyr386Ser ethA_p.Tyr386Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1204 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 554 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Tyr386* ethA_p.Tyr386* 1 stop_gained (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.55810577429468 Inf 0.0633939383341096 130.5 2233 False False Inf 0.55810577429468 Inf 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 NA Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Tyr408* ethA_p.Tyr408* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 5211 15485 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 115.692124084117 1 815 2233 False False 1.48579927077336 0.0251793916671698 28.5526337681963 0 0 0.000707651905360176 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 658 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 11 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Tyr438* ethA_p.Tyr438* 1 stop_gained (see "Genomic_coordinates" sheet) 1 2 1 1 1 2 5211 15485 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 0.333333333333333 0.00840375865961264 0.905700675949754 0.5 0.012579117093425 0.987420882906574 0.333333333333333 0.00840375865961264 0.905700675949754 2.97159854154672 0.0378490118256412 232.839631577795 0.440223474266017 417 2233 False False 1.48579927077336 0.0251793916671698 28.5526337681963 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 2 2169 3788 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999472295514512 0.998095063429584 0.999936086148442 0.333333333333333 0.00840375865961264 0.905700675949754 0.5 0.012579117093425 0.987420882906574 0.333333333333333 0.00840375865961264 0.905700675949754 1.74642692485016 0.0222380917340097 136.980247384435 1 405 1065 False False 0 0 0 0 0 0 0 0.87321346242508 0.0147995228023146 16.7833115850342 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999472295514512 0.998095063429584 0.999936086148442 NA Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Tyr461Asp ethA_p.Tyr461Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 7.19247409791798 0.577090863007554 439 2233 False False 0 0 7.19247409791798 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 2170 3787 0 0 0.00169850036174098 0.999208443271767 0.997688494809834 0.999836732216022 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.22663965322398 0.558201069943668 269 1065 False False 0 0 0 0 0 0 0 0 0 4.22663965322398 0 0 0.00169850036174098 0.999208443271767 0.997688494809834 0.999836732216022 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Tyr461Cys ethA_p.Tyr461Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 1 2 5211 15485 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 1.48579927077336 0.0251793916671698 28.5526337681963 1 815 2233 False False 1.48579927077336 0.0251793916671698 28.5526337681963 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 1 2 2169 3788 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999472295514512 0.998095063429584 0.999936086148442 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.87321346242508 0.0147995228023146 16.7833115850342 1 289.5 1065 False False 0 0 0 0 0 0 0 0.87321346242508 0.0147995228023146 16.7833115850342 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999472295514512 0.998095063429584 0.999936086148442 3 3) Uncertain significance No change no 1 +Ethionamide ethA p.Tyr461* ethA_p.Tyr461* 1 stop_gained (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 2.97179044329303 0.0378514560716107 232.854636669753 0.440205269357083 400.5 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 2 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Tyr50Asn ethA_p.Tyr50Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1185 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 545 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Tyr50Asp ethA_p.Tyr50Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 3 1 4 1 5208 15486 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.999935429715245 0.999640290494779 0.999998365223265 0.8 0.28358206388191 0.994949236620532 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 8.92050691244239 0.715990228667412 467.048854197112 0.0517619162350058 104 2233 False False 11.8940092165898 1.17652678598182 583.885453446482 0.000575705238917674 0.00011874000007229 0.00168152420898675 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.74688796680497 0.0222439624669857 137.016358245527 1 405 1065 False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 2 3) Uncertain significance No change no 1 +Ethionamide ethA p.Tyr50Cys ethA_p.Tyr50Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 12 5 7 6 7 5206 15480 0.00115118956254796 0.000422579736688136 0.00250395844332671 0.999548008006715 0.999068946905294 0.99981825708278 0.461538461538461 0.192232441801288 0.748654517729696 0.416666666666666 0.15165222980843 0.723330314317894 0.416666666666666 0.15165222980843 0.723330314317894 2.12392294605125 0.531286593864204 7.7773676053381 0.192005153850897 181 2233 False False 2.54870753526151 0.707250576895684 8.86020387579576 0.000959508731529456 0.000311620943906444 0.0022377409088434 0.999548008006715 0.999068946905294 0.99981825708278 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 5 3) Uncertain significance No change no 1 +Ethionamide ethA p.Tyr50His ethA_p.Tyr50His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Tyr60Asn ethA_p.Tyr60Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1253 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Tyr60Asp ethA_p.Tyr60Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 2 1 2 1 5210 15486 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 5.9447216890595 0.309382652589367 349.949104522224 0.158265844695452 166.5 2233 False False 5.9447216890595 0.309382652589367 349.949104522224 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 3 3) Uncertain significance No change no 1 +Ethionamide ethA p.Tyr60Cys ethA_p.Tyr60Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 5209 15487 0.000575594781273983 0.000118717215010897 0.00168120176197813 1 0.999761836368682 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1338 2233 False False Inf 1.22809956796298 Inf 0 0 0.000707923512718415 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 659 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Tyr60fs ethA_p.Tyr60fs 1 frameshift (see "Genomic_coordinates" sheet) 1 4 4 0 4 0 5208 15487 0.00076745970836531 0.000209145270149598 0.00196382534650725 1 0.999761836368682 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 1.96217557721065 Inf 0.00401648360380072 54 2233 False False Inf 1.96217557721065 Inf 0.00076745970836531 0.000209145270149598 0.00196382534650725 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 3 0 3 0 2167 3790 0.00138248847926267 0.000285193152965682 0.0040348522148252 1 0.999027154404229 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.721991535026265 Inf 0.0482234657957814 36.5 1065 False False 0 0 0 0 0 0 0 Inf 0.721991535026265 Inf 0.00138248847926267 0.000285193152965682 0.0040348522148252 1 0.999027154404229 1 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Tyr60Ser ethA_p.Tyr60Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Tyr60* ethA_p.Tyr60* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 115.699581334225 1 815 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Tyr84Asp ethA_p.Tyr84Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.55810577429468 Inf 0.0633939383341096 130.5 2233 False False Inf 0.55810577429468 Inf 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 2 3) Uncertain significance No change no 1 +Ethionamide ethA p.Tyr84Cys ethA_p.Tyr84Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 3 0 5209 15487 0.000575594781273983 0.000118717215010897 0.00168120176197813 1 0.999761836368682 1 1 0.292401773821286 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.558212886044429 Inf 0.0633757357427127 118.5 2233 False False Inf 1.22809956796298 Inf 0.000383803492611782 4.64837636131093e-05 0.00138573531807565 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 3 0 2167 3790 0.00138248847926267 0.000285193152965682 0.0040348522148252 1 0.999027154404229 1 1 0.292401773821286 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.328239646677015 Inf 0.132447859973667 55 1065 False False 0 0 0 0 0 0 0 Inf 0.721991535026265 Inf 0.000922083909635776 0.000111688152776852 0.00332687482132476 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Tyr84Ser ethA_p.Tyr84Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1267 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Tyr84* ethA_p.Tyr84* 1 stop_gained (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 5209 15487 0.000575594781273983 0.000118717215010897 0.00168120176197813 1 0.999761836368682 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1339 2233 False False Inf 1.22809956796298 Inf 0 0 0.000707923512718415 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 660 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 4 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Tyr92Cys ethA_p.Tyr92Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 8 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Tyr92His ethA_p.Tyr92His 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1386 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Tyr92* ethA_p.Tyr92* 1 stop_gained (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 2.97179044329303 0.0378514560716107 232.854636669753 0.440205269357083 400.5 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Val104fs ethA_p.Val104fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 2 0 2 1 5210 15486 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 0.666666666666666 0.0942993240502461 0.991596241340387 1 0.158113883008419 1 0.666666666666666 0.0942993240502461 0.991596241340387 Inf 0.558069736814375 Inf 0.0634000642401187 142 2233 False False 5.9447216890595 0.309382652589367 349.949104522224 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0447711586464586 Inf 0.364155059573754 211.5 1065 False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Val10Gly ethA_p.Val10Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 3 6 5209 15481 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.99961257829147 0.999156938222445 0.999857810215121 0.333333333333333 0.0748546314196918 0.700704943791459 0.333333333333333 0.00840375865961264 0.905700675949754 0.142857142857142 0.00361029686190058 0.578723197043195 1.48598579381839 0.0251825508002003 28.5562077619545 1 815 2233 False False 1.48598579381839 0.240373448133868 6.9606999827616 0.00019193857965451 4.85945229729366e-06 0.00106894424519385 0.99961257829147 0.999156938222445 0.999857810215121 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 3) Uncertain significance No change no 1 +Ethionamide ethA p.Val118fs ethA_p.Val118fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Val118Gly ethA_p.Val118Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 4 4 4 4 5208 15483 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.99974171886098 0.999338830952079 0.999929622742193 0.5 0.157012770487058 0.842987229512941 0.5 0.157012770487058 0.842987229512941 0.5 0.157012770487058 0.842987229512941 2.9729262672811 0.553517542355507 15.9639231757182 0.116279505712791 152.5 2233 False False 2.9729262672811 0.553517542355507 15.9639231757182 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 1 2 2169 3788 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999472295514512 0.998095063429584 0.999936086148442 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.87321346242508 0.0147995228023146 16.7833115850342 1 289.5 1065 False False 0 0 0 0 0 0 0 0.87321346242508 0.0147995228023146 16.7833115850342 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999472295514512 0.998095063429584 0.999936086148442 5 3) Uncertain significance No change no 1 +Ethionamide ethA p.Val118Phe ethA_p.Val118Phe 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1200 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Val158fs ethA_p.Val158fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Val179fs ethA_p.Val179fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Val179Gly ethA_p.Val179Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1358 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Val17Ala ethA_p.Val17Ala 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 1 0 8 3 5204 15484 0.00153491941673062 0.000662894835129567 0.00302215107874993 0.999806289145735 0.999434000080036 0.999960050383188 0.727272727272727 0.390257440427578 0.939782265827093 1 0.025 1 0.25 0.00630946320970987 0.805879550316756 Inf 0.0762776315902128 Inf 0.251582966793948 194 2233 False False 7.93440942864463 1.90332667827929 46.4194595369718 0.000192122958693563 4.86412034770557e-06 0.00106997063793081 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 677 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0 0 0.00170006591133688 1 0.999027154404229 1 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Val180Met ethA_p.Val180Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Val188_Ser251del ethA_p.Val188_Ser251del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Ethionamide ethA p.Val188Gly ethA_p.Val188Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 2 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Val188Ile ethA_p.Val188Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 14 0 14 6 16 5206 15471 0.00115118956254796 0.000422579736688136 0.00250395844332671 0.99896687544392 0.998322811196946 0.999409368388177 0.272727272727272 0.107289248370397 0.502221201266349 0 0 0.231635761650116 0 0 0.205907214207822 0 0 0.896318464773255 0.0279767079233297 90 2233 False False 1.11441125624279 0.356954682396465 3.00032042477003 0 0 0.000708331314907035 0.99896687544392 0.998322811196946 0.999409368388177 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 3 3 2167 3787 0.00138248847926267 0.000285193152965682 0.0040348522148252 0.999208443271767 0.997688494809834 0.999836732216022 0.5 0.118117248757025 0.881882751242974 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.23249414082777 0.558144844863702 264 1065 False False 0 0 0 0 0 0 0 1.74757729580064 0.233837130446773 13.0617462404894 0 0 0.00170084976888778 0.999208443271767 0.997688494809834 0.999836732216022 15 3) Uncertain significance No change no 1 +Ethionamide ethA p.Val191fs ethA_p.Val191fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Val191Met ethA_p.Val191Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 3 0 3 0 5209 15487 0.000575594781273983 0.000118717215010897 0.00168120176197813 1 0.999761836368682 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 1.22809956796298 Inf 0.0159579851534382 75.5 2233 False False Inf 1.22809956796298 Inf 0.000575594781273983 0.000118717215010897 0.00168120176197813 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 3 0 3 0 2167 3790 0.00138248847926267 0.000285193152965682 0.0040348522148252 1 0.999027154404229 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.721991535026265 Inf 0.0482234657957814 36.5 1065 False False 0 0 0 0 0 0 0 Inf 0.721991535026265 Inf 0.00138248847926267 0.000285193152965682 0.0040348522148252 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Val202Gly ethA_p.Val202Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 7 1 7 1 5205 15486 0.00134305448963929 0.000540142673187124 0.00276523543039201 0.999935429715245 0.999640290494779 0.999998365223265 0.875 0.473490329124793 0.996840276468748 0.875 0.473490329124793 0.996840276468748 0.875 0.473490329124793 0.996840276468748 20.8265129682997 2.6743069562409 934.137954930732 0.000399211017680222 38 2233 True False 20.8265129682997 2.6743069562409 934.137954930732 0.00134305448963929 0.000540142673187124 0.00276523543039201 0.999935429715245 0.999640290494779 0.999998365223265 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance 1 4 4 0 4 0 2166 3790 0.00184331797235023 0.00050246332413509 0.00471284227984187 1 0.999027154404229 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 1.15374841388447 Inf 0.0175424291387373 30 1065 False False 0 0 0 0 0 0 0 Inf 1.15374841388447 Inf 0.00184331797235023 0.00050246332413509 0.00471284227984187 1 0.999027154404229 1 5 Evidence from ALL dataset only 2) Assoc w R - Interim UP from Uncertain to AwRI yes ALL only 4 +Ethionamide ethA p.Val213Gly ethA_p.Val213Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Val238fs ethA_p.Val238fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.55810577429468 Inf 0.0633939383341096 130.5 2233 False False Inf 0.55810577429468 Inf 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Val238Gly ethA_p.Val238Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 1 3 1 5 5211 15482 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999677148576225 0.999246734667469 0.999895162977301 0.166666666666666 0.00421074451448947 0.641234578997674 0.25 0.00630946320970987 0.805879550316756 0.166666666666666 0.00421074451448947 0.641234578997674 0.990340945435936 0.0188609341583427 12.3357611994041 1 815 2233 False False 0.594204567261562 0.012564591702922 5.31232633024241 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999677148576225 0.999246734667469 0.999895162977301 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 1 3 1 4 2169 3786 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.998944591029023 0.997299958285064 0.999712364080324 0.2 0.00505076337946806 0.716417936118089 0.25 0.00630946320970987 0.805879550316756 0.2 0.00505076337946806 0.716417936118089 0.581834946980175 0.0110827734776091 7.25212934974105 1 405 1065 False False 0 0 0 0 0 0 0 0.436376210235131 0.00886124548211645 4.41391975850517 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.998944591029023 0.997299958285064 0.999712364080324 15 3) Uncertain significance No change no 1 +Ethionamide ethA p.Val238Ile ethA_p.Val238Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1404 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Ethionamide ethA p.Val249Ala ethA_p.Val249Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Val249fs ethA_p.Val249fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 1 1 2 1 5210 15486 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 0.666666666666666 0.0942993240502461 0.991596241340387 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 2.97236084452975 0.0378587198701314 232.899239987393 0.440151175069926 381.5 2233 False False 5.9447216890595 0.309382652589367 349.949104522224 0.000191901746305891 4.8585197621771e-06 0.00106873920290263 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0448036218670314 Inf 0.363987246182245 113 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0.000461041954817888 1.16725035605811e-05 0.00256605588112533 1 0.999027154404229 1 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Val296fs ethA_p.Val296fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Val296Met ethA_p.Val296Met 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1272 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 600 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Val310Ile ethA_p.Val310Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Ethionamide ethA p.Val313fs ethA_p.Val313fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 115.699581334225 1 815 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Val384Ala ethA_p.Val384Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Val384fs ethA_p.Val384fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Val384Gly ethA_p.Val384Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 2 1 2 1 5210 15486 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 5.9447216890595 0.309382652589367 349.949104522224 0.158265844695452 166.5 2233 False False 5.9447216890595 0.309382652589367 349.949104522224 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.74688796680497 0.0222439624669857 137.016358245527 1 405 1065 False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 3 3) Uncertain significance No change no 1 +Ethionamide ethA p.Val398dup ethA_p.Val398dup 1 inframe_insertion (see "Genomic_coordinates" sheet) 0 0 0 0 36 3 5176 15484 0.00690713737528779 0.00484222673175067 0.00954968462837135 0.999806289145735 0.999434000080036 0.999960050383188 0.923076923076923 0.791298078773556 0.983846699689341 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1359 2233 False False 35.8979907264296 11.3330217081364 182.18704803211 0 0 0.000712435327281524 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 670 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 29 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Ethionamide ethA p.Val398Leu ethA_p.Val398Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1268 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 597 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Val402Phe ethA_p.Val402Phe 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 1 5208 15486 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.999935429715245 0.999640290494779 0.999998365223265 0.8 0.28358206388191 0.994949236620532 NA NA NA 0 0 0.975 NA NA NA NA 1218 2233 False False 11.8940092165898 1.17652678598182 583.885453446482 0 0 0.000708059394597755 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 1 2168 3789 0.000921658986175115 0.000111636674590768 0.0033253435449308 0.999736147757256 0.998530795728906 0.999993319861894 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 564 1065 False False 0 0 0 0 0 0 0 3.49538745387453 0.181825522231654 206.012215468794 0 0 0.00170006591133688 0.999736147757256 0.998530795728906 0.999993319861894 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Val417Glu ethA_p.Val417Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1330 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 653 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 2 3) Uncertain significance No change no 1 +Ethionamide ethA p.Val419Ile ethA_p.Val419Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1186 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 546 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide ethA p.Val426Phe ethA_p.Val426Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Val489fs ethA_p.Val489fs 1 frameshift (see "Genomic_coordinates" sheet) 1 3 0 3 3 5 5209 15482 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.999677148576225 0.999246734667469 0.999895162977301 0.375 0.0852334141372535 0.755136783633448 0 0 0.707598226178713 0 0 0.521823750104981 0 0 7.19568810328533 0.577137072359492 454 2233 False False 1.78329813783835 0.27682812068913 9.16959691894064 0 0 0.000707923512718415 0.999677148576225 0.999246734667469 0.999895162977301 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 2170 3786 0 0 0.00169850036174098 0.998944591029023 0.997299958285064 0.999712364080324 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 4.22552383530444 0.558211832626427 274 1065 False False 0 0 0 0 0 0 0 0 0 2.6454264678615 0 0 0.00169850036174098 0.998944591029023 0.997299958285064 0.999712364080324 3 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Val489Phe ethA_p.Val489Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Val7Ala ethA_p.Val7Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 1 3) Uncertain significance No change no 1 +Ethionamide ethA p.Val7Gly ethA_p.Val7Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 2.97179044329303 0.0378514560716107 232.854636669753 0.440205269357083 400.5 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethA p.Val85del ethA_p.Val85del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Ethionamide ethA p.Val85fs ethA_p.Val85fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0762045661509476 Inf 0.251763455406319 213.5 2233 False False Inf 0.55810577429468 Inf 0.000191901746305891 4.8585197621771e-06 0.00106873920290263 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0448036218670314 Inf 0.363987246182245 113 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0.000461041954817888 1.16725035605811e-05 0.00256605588112533 1 0.999027154404229 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Ethionamide ethA p.Val85Gly ethA_p.Val85Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1396 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 693 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ethR c.120T>C ethR_c.120T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethR c.124C>T ethR_c.124C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethR c.-14A>G ethR_c.-14A>G 2 upstream_gene_variant 4327535 1 0 0 0 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2053 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 986 1065 False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 0 0 0.0016992827759538 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide ethR c.171G>A ethR_c.171G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0761899451219867 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethR c.183C>T ethR_c.183C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethR c.189C>T ethR_c.189C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.19247409791798 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethR c.192T>C ethR_c.192T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 5209 15487 0.000575594781273983 0.000118717215010897 0.00168120176197813 1 0.999761836368682 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.22809956796298 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 2167 3790 0.00138248847926267 0.000285193152965682 0.0040348522148252 1 0.999027154404229 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.721991535026265 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethR c.-19C>T ethR_c.-19C>T 2 upstream_gene_variant 4327530 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2018 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 969 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 8 3) Uncertain significance No change no 1 +Ethionamide ethR c.-2_-1insA ethR_c.-2_-1insA 2 upstream_gene_variant 4327547 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2029 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 976 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 7 3) Uncertain significance New Uncertain no 0 +Ethionamide ethR c.201C>T ethR_c.201C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethR c.214C>T ethR_c.214C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethR c.-21G>A ethR_c.-21G>A 2 upstream_gene_variant 4327528 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2016 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethionamide ethR c.228G>C ethR_c.228G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethR c.237G>A ethR_c.237G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethR c.240C>A ethR_c.240C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethR c.285C>T ethR_c.285C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethR c.288C>T ethR_c.288C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 5211 15485 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.48579927077336 0.0251793916671698 28.5526337681963 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethR c.297C>A ethR_c.297C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethR c.342C>T ethR_c.342C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0761899451219867 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethR c.357G>A ethR_c.357G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethR c.369C>T ethR_c.369C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethR c.36T>G ethR_c.36T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0761899451219867 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethR c.396C>A ethR_c.396C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethR c.-3A>C ethR_c.-3A>C 2 upstream_gene_variant 4327546 1 0 0 0 1 5 5211 15482 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999677148576225 0.999246734667469 0.999895162977301 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA 0 0 0.521823750104981 NA NA NA NA 2057 2233 False False 0.594204567261562 0.012564591702922 5.31232633024241 0 0 0.000707651905360176 0.999677148576225 0.999246734667469 0.999895162977301 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 988 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 1 3) Uncertain significance No change no 1 +Ethionamide ethR c.-3A>G ethR_c.-3A>G 2 upstream_gene_variant 4327546 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2034 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethR c.420G>A ethR_c.420G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 5212 15482 0 0 0.000707516179821284 0.999677148576225 0.999246734667469 0.999895162977301 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.24289311550326 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethR c.441C>T ethR_c.441C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethR c.456G>A ethR_c.456G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 11 124 5201 15363 0.0021105141980046 0.00105401717787221 0.00377314786388412 0.991993284690385 0.990461010054498 0.993336147127216 0.0814814814814814 0.0413775048760789 0.141115484539079 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.262035526666708 0.127379159622933 0.485846091650217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 5 14 2165 3776 0.00230414746543778 0.000748560476988087 0.00536885389822181 0.996306068601583 0.993809970169066 0.997979066953146 0.263157894736842 0.0914657849076665 0.512029345345872 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.622896733751237 0.175373925514018 1.83339685322559 NA NA NA NA NA NA 354 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethR c.468A>G ethR_c.468A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethR c.480C>A ethR_c.480C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethR c.486G>C ethR_c.486G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethR c.489G>A ethR_c.489G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 5 5210 15482 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999677148576225 0.999246734667469 0.999895162977301 0.285714285714285 0.0366925661760855 0.709579136262657 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.18863723608445 0.113129903278746 7.26455938498844 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 11 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethR c.492C>G ethR_c.492C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.19247409791798 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethR c.513G>A ethR_c.513G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethR c.549G>A ethR_c.549G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0761899451219867 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethR c.54G>A ethR_c.54G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 13 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethR c.552C>T ethR_c.552C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethR c.555G>A ethR_c.555G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethR c.579G>C ethR_c.579G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 16 0 5196 15487 0.00306983883346124 0.00175566480963699 0.00498045124723913 1 0.999761836368682 1 1 0.794092785792177 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 11.4880049707376 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 16 0 2154 3790 0.00737327188940092 0.00422016334684143 0.0119461840501788 1 0.999027154404229 1 1 0.794092785792177 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 6.77552719893891 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethR c.597G>A ethR_c.597G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 8 5211 15479 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99948343772196 0.998982421476308 0.999776959534822 0.111111111111111 0.00280913674659921 0.482496514917337 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.371305891383611 0.00836999418610458 2.77069344974123 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethR c.597G>C ethR_c.597G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 5212 15483 0 0 0.000707516179821284 0.99974171886098 0.999338830952079 0.999929622742193 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.5014696306354 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethR c.-5C>T ethR_c.-5C>T 2 upstream_gene_variant 4327544 1 0 0 0 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2003 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethR c.60G>A ethR_c.60G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0761899451219867 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethR c.639C>T ethR_c.639C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethR c.645C>T ethR_c.645C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethR c.6C>T ethR_c.6C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.19247409791798 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ethR c.-6G>A ethR_c.-6G>A 2 upstream_gene_variant 4327543 NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2010 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethR LoF ethR_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 0 0 0 1 5 5211 15482 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999677148576225 0.999246734667469 0.999895162977301 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA 0 0 0.521823750104981 NA NA NA NA 2233 2233 False False 0.594204567261562 0.012564591702922 5.31232633024241 0 0 0.000707651905360176 0.999677148576225 0.999246734667469 0.999895162977301 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1065 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethR p.Ala129Val ethR_p.Ala129Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1998 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethR p.Ala151Ser ethR_p.Ala151Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2050 2233 False False 0 0 7.19247409791798 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethR p.Ala155Val ethR_p.Ala155Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2030 2233 False False 0 0 7.19247409791798 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethR p.Ala161Thr ethR_p.Ala161Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2031 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethR p.Ala161Val ethR_p.Ala161Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 5212 15483 0 0 0.000707516179821284 0.99974171886098 0.999338830952079 0.999929622742193 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 2027 2233 False False 0 0 4.5014696306354 0 0 0.000707516179821284 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 975 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 8 3) Uncertain significance No change no 1 +Ethionamide ethR p.Ala162Pro ethR_p.Ala162Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2013 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 968 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethR p.Ala174Thr ethR_p.Ala174Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethR p.Ala28Thr ethR_p.Ala28Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2032 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethR p.Ala43Asp ethR_p.Ala43Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2033 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethR p.Ala43Thr ethR_p.Ala43Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2007 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethR p.Ala5Val ethR_p.Ala5Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2008 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 965 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethR p.Ala70Pro ethR_p.Ala70Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethR p.Ala83Thr ethR_p.Ala83Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2014 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethR p.Ala91Thr ethR_p.Ala91Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethR p.Ala95Thr ethR_p.Ala95Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 46 49 5166 15438 0.00882578664620107 0.00646862466315748 0.0117549988124001 0.996836056047007 0.995819230294592 0.997658407981462 0.484210526315789 0.380385881696619 0.589046206127158 NA NA NA 0 0 0.0725192636642774 NA NA NA NA 2045 2233 False False 2.805423214582 1.83202355762435 4.28861945101009 0 0 0.000713813919990951 0.996836056047007 0.995819230294592 0.997658407981462 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 5 3 2165 3787 0.00230414746543778 0.000748560476988087 0.00536885389822181 0.999208443271767 0.997688494809834 0.999836732216022 0.625 0.244863216366551 0.914766585862746 NA NA NA 0 0 0.707598226178713 NA NA NA NA 980 1065 False False 0 0 0 0 0 0 0 2.9153194765204 0.566479632607818 18.786985063018 0 0 0.00170241965449235 0.999208443271767 0.997688494809834 0.999836732216022 288 3) Uncertain significance No change no 1 +Ethionamide ethR p.Arg104Leu ethR_p.Arg104Leu 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2043 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 979 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 1 3) Uncertain significance No change no 1 +Ethionamide ethR p.Arg122Gln ethR_p.Arg122Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2005 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 962 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide ethR p.Arg16His ethR_p.Arg16His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2009 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethR p.Arg198Ser ethR_p.Arg198Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2011 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 966 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethR p.Arg216Cys ethR_p.Arg216Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2004 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance No change no 1 +Ethionamide ethR p.Arg216His ethR_p.Arg216His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2035 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethR p.Arg99His ethR_p.Arg99His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2051 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethR p.Asn93Ser ethR_p.Asn93Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 1 7 5211 15480 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999548008006715 0.999068946905294 0.99981825708278 0.125 0.0031597235312519 0.526509670875206 0 0 0.4592581264399 0 0 0.409616397225003 0 0 2.52389881974828 0.347646552290745 361 2233 False False 0.424377004687885 0.00941807225879499 3.30463580134316 0 0 0.000707651905360176 0.999548008006715 0.999068946905294 0.99981825708278 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 2170 3787 0 0 0.00169850036174098 0.999208443271767 0.997688494809834 0.999836732216022 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 9.29752209151186 0.536829969545164 228 1065 False False 0 0 0 0 0 0 0 0 0 4.22663965322398 0 0 0.00169850036174098 0.999208443271767 0.997688494809834 0.999836732216022 16 3) Uncertain significance No change no 1 +Ethionamide ethR p.Asp158Gly ethR_p.Asp158Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2052 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 985 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 1 3) Uncertain significance No change no 1 +Ethionamide ethR p.Asp23Glu ethR_p.Asp23Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2038 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethR p.Asp23Gly ethR_p.Asp23Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2039 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethR p.Asp44Tyr ethR_p.Asp44Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2006 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 963 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide ethR p.Asp48Asn ethR_p.Asp48Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2021 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 970 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethR p.Asp48Glu ethR_p.Asp48Glu 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2000 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethR p.Asp48Gly ethR_p.Asp48Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 15 5212 15472 0 0 0.000707516179821284 0.999031445728675 0.998403019382043 0.999457809400789 0 0 0.218019360910534 NA NA NA 0 0 0.218019360910534 NA NA NA NA 2046 2233 False False 0 0 0.82801706712187 0 0 0.000707516179821284 0.999031445728675 0.998403019382043 0.999457809400789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 981 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 19 3) Uncertain significance No change no 1 +Ethionamide ethR p.Asp49Ala ethR_p.Asp49Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2001 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 961 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 6 3) Uncertain significance New Uncertain no 0 +Ethionamide ethR p.Asp77Asn ethR_p.Asp77Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2019 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethR p.Asp84Ala ethR_p.Asp84Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2064 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 992 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 1 3) Uncertain significance No change no 1 +Ethionamide ethR p.Gln143Lys ethR_p.Gln143Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 7 5212 15480 0 0 0.000707516179821284 0.999548008006715 0.999068946905294 0.99981825708278 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 2036 2233 False False 0 0 2.06147084147984 0 0 0.000707516179821284 0.999548008006715 0.999068946905294 0.99981825708278 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 977 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 16 3) Uncertain significance No change no 1 +Ethionamide ethR p.Glu100Lys ethR_p.Glu100Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2054 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 987 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethR p.Glu156Ala ethR_p.Glu156Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2040 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethR p.Glu170Asp ethR_p.Glu170Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2041 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethR p.Glu190Gln ethR_p.Glu190Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethR p.Gly106Arg ethR_p.Gly106Arg 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 6 5210 15481 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.99961257829147 0.999156938222445 0.999857810215121 0.25 0.0318540262499442 0.650855794412824 NA NA NA 0 0 0.4592581264399 NA NA NA NA 2023 2233 False False 0.990467050543826 0.097726046324841 5.54070950742461 0 0 0.000707787682982558 0.99961257829147 0.999156938222445 0.999857810215121 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 971 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 9 3) Uncertain significance No change no 1 +Ethionamide ethR p.Gly115Arg ethR_p.Gly115Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2037 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 978 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 1 3) Uncertain significance No change no 1 +Ethionamide ethR p.Gly124Cys ethR_p.Gly124Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 4 5211 15483 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99974171886098 0.999338830952079 0.999929622742193 0.2 0.00505076337946806 0.716417936118089 NA NA NA 0 0 0.602364635616474 NA NA NA NA 2059 2233 False False 0.742803684513529 0.0150842538989179 7.50989306640636 0 0 0.000707651905360176 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Ethionamide ethR p.Gly14Val ethR_p.Gly14Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2017 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethR p.Gly189Arg ethR_p.Gly189Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethR p.Gly189Ser ethR_p.Gly189Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethR p.Ile146Met ethR_p.Ile146Met 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 3 5211 15484 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999806289145735 0.999434000080036 0.999960050383188 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2024 2233 False False 0.990468879933474 0.0188633706776044 12.3373543450537 0 0 0.000707651905360176 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 972 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 4 3) Uncertain significance No change no 1 +Ethionamide ethR p.Ile153Val ethR_p.Ile153Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 3 29 5209 15458 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.998127461742106 0.997311821114039 0.998745584192766 0.09375 0.0197671801732848 0.250226950683794 0 0 0.841886116991581 0 0 0.119444869069502 0 0 15.8048178259239 1 815 2233 False False 0.306988567532321 0.0598265408305715 0.991049421953334 0 0 0.000707923512718415 0.998127461742106 0.997311821114039 0.998745584192766 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 964 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 59 3) Uncertain significance No change no 1 +Ethionamide ethR p.Ile45Met ethR_p.Ile45Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2015 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance No change no 1 +Ethionamide ethR p.Leu171Met ethR_p.Leu171Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2026 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 974 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethR p.Leu27fs ethR_p.Leu27fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2055 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethR p.Leu42Pro ethR_p.Leu42Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 1 5210 15486 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 2060 2233 False False 5.9447216890595 0.309382652589367 349.949104522224 0 0 0.000707787682982558 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethR p.Leu76Val ethR_p.Leu76Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2044 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethR p.Met1? ethR_p.Met1? 2 start_lost (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1999 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 960 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 4 3) Uncertain significance New Uncertain no 0 +Ethionamide ethR p.Met102Ile ethR_p.Met102Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2047 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 982 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 4 3) Uncertain significance New Uncertain no 0 +Ethionamide ethR p.Met142Ile ethR_p.Met142Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2048 2233 False False 0 0 7.19247409791798 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 983 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 16 3) Uncertain significance No change no 1 +Ethionamide ethR p.Met85Ile ethR_p.Met85Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2056 2233 False False 0 0 7.19247409791798 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 3) Uncertain significance No change no 1 +Ethionamide ethR p.Phe110Leu ethR_p.Phe110Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 19 5210 15468 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.998773164589655 0.998084804605634 0.999261208414407 0.0952380952380952 0.0117493178844458 0.303774406913924 NA NA NA 0 0 0.176466911806965 NA NA NA NA 2061 2233 False False 0.312516415799575 0.0352876647287072 1.29613417643732 0 0 0.000707787682982558 0.998773164589655 0.998084804605634 0.999261208414407 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 4 2169 3786 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.998944591029023 0.997299958285064 0.999712364080324 0.2 0.00505076337946806 0.716417936118089 NA NA NA 0 0 0.602364635616474 NA NA NA NA 990 1065 False False 0 0 0 0 0 0 0 0.436376210235131 0.00886124548211645 4.41391975850517 0 0 0.0016992827759538 0.998944591029023 0.997299958285064 0.999712364080324 89 3) Uncertain significance No change no 1 +Ethionamide ethR p.Phe111Leu ethR_p.Phe111Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2049 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 984 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethR p.Phe184Leu ethR_p.Phe184Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Ethionamide ethR p.Phe61Leu ethR_p.Phe61Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2012 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 967 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 NA 3) Uncertain significance No change no 1 +Ethionamide ethR p.Pro163Leu ethR_p.Pro163Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethR p.Pro192Ala ethR_p.Pro192Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2042 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethR p.Pro94Ser ethR_p.Pro94Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 5211 15485 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 115.692124084117 1 815 2233 False False 1.48579927077336 0.0251793916671698 28.5526337681963 0 0 0.000707651905360176 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 68.0751891811639 1 405 1065 False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 0 0 0.0016992827759538 0.999736147757256 0.998530795728906 0.999993319861894 19 3) Uncertain significance No change no 1 +Ethionamide ethR p.Ser10Trp ethR_p.Ser10Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethR p.Ser131Arg ethR_p.Ser131Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 3 4 5209 15483 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.99974171886098 0.999338830952079 0.999929622742193 0.428571428571428 0.0989882784425078 0.815948432359917 NA NA NA 0 0 0.602364635616474 NA NA NA NA 2025 2233 False False 2.2292666538683 0.326438409930677 13.182222747906 0 0 0.000707923512718415 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 2 2169 3788 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999472295514512 0.998095063429584 0.999936086148442 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 973 1065 False False 0 0 0 0 0 0 0 0.87321346242508 0.0147995228023146 16.7833115850342 0 0 0.0016992827759538 0.999472295514512 0.998095063429584 0.999936086148442 5 3) Uncertain significance No change no 1 +Ethionamide ethR p.Ser186Leu ethR_p.Ser186Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 5212 15483 0 0 0.000707516179821284 0.99974171886098 0.999338830952079 0.999929622742193 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 15.8212548517015 1 496.5 2233 False False 0 0 4.5014696306354 0 0 0.000707516179821284 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.2999762698034 0.53686319604546 244.5 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 NA 3) Uncertain significance No change no 1 +Ethionamide ethR p.Thr113Ala ethR_p.Thr113Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethR p.Thr113Ile ethR_p.Thr113Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2020 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ethR p.Thr140Met ethR_p.Thr140Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 1 3) Uncertain significance No change no 1 +Ethionamide ethR p.Thr149Met ethR_p.Thr149Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 5212 15483 0 0 0.000707516179821284 0.99974171886098 0.999338830952079 0.999929622742193 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 15.8212548517015 1 496.5 2233 False False 0 0 4.5014696306354 0 0 0.000707516179821284 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 10 3) Uncertain significance No change no 1 +Ethionamide ethR p.Thr165Ile ethR_p.Thr165Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethR p.Thr173Arg ethR_p.Thr173Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2028 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethR p.Thr17Ala ethR_p.Thr17Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethR p.Thr2Ala ethR_p.Thr2Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethR p.Thr32Ser ethR_p.Thr32Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ethR p.Thr3Ala ethR_p.Thr3Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 12 5212 15475 0 0 0.000707516179821284 0.99922515658294 0.998646896080726 0.999599565042795 0 0 0.264648469397051 0 0 0.975 0 0 0.264648469397051 0 0 115.595408600564 1 815 2233 False False 0 0 1.06903209420596 0 0 0.000707516179821284 0.99922515658294 0.998646896080726 0.999599565042795 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 36 3) Uncertain significance No change no 1 +Ethionamide ethR p.Thr3Ile ethR_p.Thr3Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2062 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethR p.Thr74Ala ethR_p.Thr74Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 5211 15485 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8263323782973 1 815 2233 False False 1.48579927077336 0.0251793916671698 28.5526337681963 0 0 0.000707651905360176 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 5 3) Uncertain significance No change no 1 +Ethionamide ethR p.Thr89fs ethR_p.Thr89fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2065 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethR p.Trp145* ethR_p.Trp145* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2002 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethR p.Val109Ala ethR_p.Val109Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethR p.Val120Ala ethR_p.Val120Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2063 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 991 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 2 3) Uncertain significance No change no 1 +Ethionamide ethR p.Val132Ala ethR_p.Val132Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ethR p.Val199Ala ethR_p.Val199Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2022 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ethR p.Val80Leu ethR_p.Val80Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2058 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 989 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide inhA c.-10_-9insAGG inhA_c.-10_-9insAGG 1 upstream_gene_variant 1674192 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1177 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide inhA c.-100C>A inhA_c.-100C>A 1 upstream_gene_variant 1674102 1 11 2 9 21 19 5191 15468 0.00402916346891788 0.00249579323336676 0.00615244395242943 0.998773164589655 0.998084804605634 0.999261208414407 0.525 0.361280135264062 0.684880293365014 0.181818181818181 0.0228311982999596 0.517755852360172 0.0952380952380952 0.0117493178844458 0.303774406913924 0.662171707442368 0.0696001196634299 3.20045027580661 0.741412834554591 485 2233 False False 3.29343296596335 1.68386806157564 6.48092730457497 0.000385133834007317 4.66448976023302e-05 0.00139053614380499 0.998773164589655 0.998084804605634 0.999261208414407 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 5 8 2165 3782 0.00230414746543778 0.000748560476988087 0.00536885389822181 0.997889182058047 0.995845105987758 0.999088271930771 0.384615384615384 0.13857933889016 0.684222397085936 0 0 0.4592581264399 0 0 0.369416647552819 0 0 1.48527667463842 0.0928285979641004 49 1065 False False 0 0 0 0 0 0 0 1.09180138568129 0.280654831315899 3.79054153800723 0 0 0.00170241965449235 0.997889182058047 0.995845105987758 0.999088271930771 9 3) Uncertain significance No change no 1 +Ethionamide inhA c.-11_-10insAAG inhA_c.-11_-10insAAG 1 upstream_gene_variant 1674191 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1130 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide inhA c.-11_-10insAAGG inhA_c.-11_-10insAAGG 1 upstream_gene_variant 1674191 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide inhA c.-11_-10insAAGGA inhA_c.-11_-10insAAGGA 1 upstream_gene_variant 1674191 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1167 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 535 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide inhA c.-112C>T inhA_c.-112C>T 1 upstream_gene_variant 1674090 1 8 0 8 0 10 5212 15477 0 0 0.000707516179821284 0.99935429715245 0.998812851129914 0.999690318343011 0 0 0.30849710781876 0 0 0.369416647552819 0 0 0.30849710781876 0 0 1.74028154337766 0.214450564643988 192 2233 False False 0 0 1.32532562767373 0 0 0.000707516179821284 0.99935429715245 0.998812851129914 0.999690318343011 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide inhA c.123C>T inhA_c.123C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide inhA c.-127C>A inhA_c.-127C>A 1 upstream_gene_variant 1674075 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1173 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 538 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide inhA c.138G>A inhA_c.138G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide inhA c.-140C>A inhA_c.-140C>A 1 upstream_gene_variant 1674062 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1175 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide inhA c.150C>T inhA_c.150C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide inhA c.-154G>A inhA_c.-154G>A 1 upstream_gene_variant 1674048 1 145 67 78 309 138 4903 15349 0.0592862624712202 0.053027196045714 0.0660442979208624 0.991089300703816 0.989481002590938 0.992508815893944 0.691275167785234 0.646166540411946 0.733830544420985 0.462068965517241 0.379002596841842 0.54671676222698 0.326829268292682 0.263113097597972 0.395639744495802 2.68904699895929 1.907183646209 3.78204915895169 8.95171059798654e-09 17 2233 True False 7.00967021078487 5.70118554505376 8.6548062152978 0.0134808853118712 0.0104623614020083 0.0170890306078758 0.991089300703816 0.989481002590938 0.992508815893944 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance 1 60 31 29 146 76 2024 3714 0.0672811059907834 0.0571007822318353 0.0786480006627188 0.979947229551451 0.97496449781135 0.984168974255809 0.657657657657657 0.591199228304917 0.719840756187626 0.516666666666666 0.383946017331596 0.647687069997873 0.289719626168224 0.206075337478444 0.385366260247204 1.96153059833719 1.13986891732338 3.38348850449123 0.00983649969494496 24 1065 False False 0 0 0 0 0 0 0 3.52509361348034 2.63796806751298 4.74018337414654 0.0150851581508515 0.0102720410919062 0.0213443396545435 0.979947229551451 0.97496449781135 0.984168974255809 459 Assoc w RI Evidence from ALL dataset only 2) Assoc w R - Interim Alias fabG1_p.Leu203Leu No change yes ALL only H 1 +Ethionamide inhA c.-156C>T inhA_c.-156C>T 1 upstream_gene_variant 1674046 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide inhA c.-158C>T inhA_c.-158C>T 1 upstream_gene_variant 1674044 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide inhA c.159G>T inhA_c.159G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide inhA c.-160G>A inhA_c.-160G>A 1 upstream_gene_variant 1674042 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1146 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide inhA c.-16C>G inhA_c.-16C>G 1 upstream_gene_variant 1674186 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1156 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide inhA c.171G>A inhA_c.171G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide inhA c.174C>A inhA_c.174C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide inhA c.-176A>C inhA_c.-176A>C 1 upstream_gene_variant 1674026 1 12 2 10 2 11 5210 15476 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999289726867695 0.998729481387772 0.999645382583254 0.153846153846153 0.0192066719825284 0.454471055676557 0.166666666666666 0.0208625254600923 0.484137748685967 0.153846153846153 0.0192066719825284 0.454471055676557 0.594088291746641 0.0632720625043199 2.78913518186107 0.741848945067072 486 2233 False False 0.540080265224219 0.0581555408985981 2.47593717799149 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999289726867695 0.998729481387772 0.999645382583254 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 2 2 2 2 2168 3788 0.000921658986175115 0.000111636674590768 0.0033253435449308 0.999472295514512 0.998095063429584 0.999936086148442 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 1.74723247232472 0.126540110696744 24.1244851777313 0.625418981130684 278.5 1065 False False 0 0 0 0 0 0 0 1.74723247232472 0.126540110696744 24.1244851777313 0.000921658986175115 0.000111636674590768 0.0033253435449308 0.999472295514512 0.998095063429584 0.999936086148442 7 3) Uncertain significance No change no 1 +Ethionamide inhA c.-180G>A inhA_c.-180G>A 1 upstream_gene_variant 1674022 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1131 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide inhA c.-18C>A inhA_c.-18C>A 1 upstream_gene_variant 1674184 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide inhA c.-18C>T inhA_c.-18C>T 1 upstream_gene_variant 1674184 1 1 0 1 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 115.669966941234 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide inhA c.-19_-18insCACAACAC inhA_c.-19_-18insCACAACAC 1 upstream_gene_variant 1674183 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1140 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 524 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide inhA c.-20G>A inhA_c.-20G>A 1 upstream_gene_variant 1674182 1 3 0 3 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 7.19247409791798 0.577090863007554 439 2233 False False 0 0 7.19247409791798 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 2170 3787 0 0 0.00169850036174098 0.999208443271767 0.997688494809834 0.999836732216022 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.22663965322398 0.558201069943668 269 1065 False False 0 0 0 0 0 0 0 0 0 4.22663965322398 0 0 0.00169850036174098 0.999208443271767 0.997688494809834 0.999836732216022 NA 3) Uncertain significance No change no 1 +Ethionamide inhA c.213G>A inhA_c.213G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 5212 15483 0 0 0.000707516179821284 0.99974171886098 0.999338830952079 0.999929622742193 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.5014696306354 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide inhA c.-214G>A inhA_c.-214G>A 1 upstream_gene_variant 1673988 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide inhA c.222G>A inhA_c.222G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide inhA c.228C>T inhA_c.228C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide inhA c.-235G>A inhA_c.-235G>A 1 upstream_gene_variant 1673967 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide inhA c.237C>T inhA_c.237C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide inhA c.-25C>T inhA_c.-25C>T 1 upstream_gene_variant 1674177 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Ethionamide inhA c.264C>T inhA_c.264C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.97179044329303 0.0378514560716107 232.854636669753 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide inhA c.267C>T inhA_c.267C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide inhA c.273G>A inhA_c.273G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide inhA c.-277C>T inhA_c.-277C>T 1 upstream_gene_variant 1673925 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide inhA c.-282A>G inhA_c.-282A>G 1 upstream_gene_variant 1673920 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1165 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 534 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide inhA c.291C>T inhA_c.291C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 20 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide inhA c.303C>T inhA_c.303C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide inhA c.-312G>A inhA_c.-312G>A 1 upstream_gene_variant 1673890 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide inhA c.31C>T inhA_c.31C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide inhA c.321G>A inhA_c.321G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0761899451219867 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide inhA c.324C>T inhA_c.324C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide inhA c.-337C>T inhA_c.-337C>T 1 upstream_gene_variant 1673865 1 19 0 19 7 34 5205 15453 0.00134305448963929 0.000540142673187124 0.00276523543039201 0.997804610318331 0.996933501541924 0.99847916441176 0.170731707317073 0.0715152881522945 0.320560879448909 0 0 0.176466911806965 0 0 0.102817924259012 0 0 0.636475142039068 0.00645379408273318 60 2233 False False 0.611239193083573 0.228519231932559 1.4019112303642 0 0 0.000708467353397108 0.997804610318331 0.996933501541924 0.99847916441176 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 0 1 3 1 2167 3789 0.00138248847926267 0.000285193152965682 0.0040348522148252 0.999736147757256 0.998530795728906 0.999993319861894 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 68.1379512601278 1 405 1065 False False 0 0 0 0 0 0 0 5.2455006922012 0.420751345257316 275.029142692281 0 0 0.00170084976888778 0.999736147757256 0.998530795728906 0.999993319861894 15 3) Uncertain significance No change no 1 +Ethionamide inhA c.-351A>G inhA_c.-351A>G 1 upstream_gene_variant 1673851 1 1 0 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 115.699581334225 1 815 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 540 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide inhA c.351C>T inhA_c.351C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide inhA c.354G>A inhA_c.354G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide inhA c.357C>A inhA_c.357C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide inhA c.-358G>T inhA_c.-358G>T 1 upstream_gene_variant 1673844 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide inhA c.-360A>G inhA_c.-360A>G 1 upstream_gene_variant 1673842 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1169 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide inhA c.369G>A inhA_c.369G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.19247409791798 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide inhA c.-375A>C inhA_c.-375A>C 1 upstream_gene_variant 1673827 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide inhA c.384T>G inhA_c.384T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide inhA c.-386G>A inhA_c.-386G>A 1 upstream_gene_variant 1673816 1 13 0 13 0 14 5212 15473 0 0 0.000707516179821284 0.99909601601343 0.998483733164878 0.999505698211522 0 0 0.231635761650116 0 0 0.24705263800047 0 0 0.231635761650116 0 0 0.9745118868448019 0.048203635518804 96 2233 False False 0 0 0.895402656698445 0 0 0.000707516179821284 0.99909601601343 0.998483733164878 0.999505698211522 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 2170 3784 0 0 0.00169850036174098 0.998416886543535 0.996557436795264 0.999418810659556 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.48263576179074 0.0927092577734561 46 1065 False False 0 0 0 0 0 0 0 0 0 1.48263576179074 0 0 0.00169850036174098 0.998416886543535 0.996557436795264 0.999418810659556 24 3) Uncertain significance No change no 1 +Ethionamide inhA c.-391G>T inhA_c.-391G>T 1 upstream_gene_variant 1673811 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide inhA c.-40C>T inhA_c.-40C>T 1 upstream_gene_variant 1674162 1 60 2 58 18 64 5194 15423 0.00345356868764389 0.00204804863805522 0.00545265611077246 0.995867501775682 0.994725913994443 0.996816061984566 0.219512195121951 0.135592420770655 0.324554922748219 0.0333333333333333 0.00406262464209349 0.115281044419251 0.0303030303030303 0.00369113896142986 0.105216648579651 0.102392681210415 0.0120867906464564 0.387189324740779 8.88517320509265e-06 24 2233 True False 0.835140306122448 0.465323856866753 1.42847621075106 0.000384911470361816 4.66179644039043e-05 0.00138973369747892 0.995867501775682 0.994725913994443 0.996816061984566 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 24 1 23 14 25 2156 3765 0.0064516129032258 0.00353151253161303 0.0108010403945548 0.993403693931398 0.990277852200461 0.995726803192758 0.358974358974359 0.212037185560799 0.528204886374588 0.0416666666666666 0.00105435244546974 0.211201683456973 0.0384615384615384 0.00097328789333503 0.196369646762539 0.0759256271678631 0.00184650716748434 0.468358512273702 0.000413455103163596 16 1065 True False 0 0 0 0 0 0 0 0.977922077922078 0.468855039344477 1.95992921546648 0.000463606861381548 1.17374406123622e-05 0.00258031644859463 0.993403693931398 0.990277852200461 0.995726803192758 731 3) Uncertain significance No change no 1 +Ethionamide inhA c.-424C>T inhA_c.-424C>T 1 upstream_gene_variant 1673778 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethionamide inhA c.-436C>T inhA_c.-436C>T 1 upstream_gene_variant 1673766 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1176 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance No change no 1 +Ethionamide inhA c.-466G>T inhA_c.-466G>T 1 upstream_gene_variant 1673736 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Ethionamide inhA c.-472C>T inhA_c.-472C>T 1 upstream_gene_variant 1673730 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1163 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide inhA c.477C>T inhA_c.477C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.19247409791798 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide inhA c.-478A>C inhA_c.-478A>C 1 upstream_gene_variant 1673724 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide inhA c.486G>A inhA_c.486G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide inhA c.-486G>T inhA_c.-486G>T 1 upstream_gene_variant 1673716 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1127 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide inhA c.-487C>A inhA_c.-487C>A 1 upstream_gene_variant 1673715 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide inhA c.-487C>G inhA_c.-487C>G 1 upstream_gene_variant 1673715 1 1 0 1 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 115.669966941234 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 12 3) Uncertain significance New Uncertain no 0 +Ethionamide inhA c.-510C>G inhA_c.-510C>G 1 upstream_gene_variant 1673692 0 0 0 0 3 0 5209 15487 0.000575594781273983 0.000118717215010897 0.00168120176197813 1 0.999761836368682 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1161 2233 False False Inf 1.22809956796298 Inf 0 0 0.000707923512718415 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethionamide inhA c.-520G>C inhA_c.-520G>C 1 upstream_gene_variant 1673682 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide inhA c.-522C>G inhA_c.-522C>G 1 upstream_gene_variant 1673680 1 0 0 0 0 14 5212 15473 0 0 0.000707516179821284 0.99909601601343 0.998483733164878 0.999505698211522 0 0 0.231635761650116 NA NA NA 0 0 0.231635761650116 NA NA NA NA 1151 2233 False False 0 0 0.895402656698445 0 0 0.000707516179821284 0.99909601601343 0.998483733164878 0.999505698211522 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 2170 3786 0 0 0.00169850036174098 0.998944591029023 0.997299958285064 0.999712364080324 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 529 1065 False False 0 0 0 0 0 0 0 0 0 2.6454264678615 0 0 0.00169850036174098 0.998944591029023 0.997299958285064 0.999712364080324 48 3) Uncertain significance No change no 1 +Ethionamide inhA c.522C>T inhA_c.522C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0761899451219867 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide inhA c.-523T>C inhA_c.-523T>C 1 upstream_gene_variant 1673679 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethionamide inhA c.-526G>T inhA_c.-526G>T 1 upstream_gene_variant 1673676 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1157 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide inhA c.-529C>A inhA_c.-529C>A 1 upstream_gene_variant 1673673 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide inhA c.537C>A inhA_c.537C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide inhA c.-541G>C inhA_c.-541G>C 1 upstream_gene_variant 1673661 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Ethionamide inhA c.-547C>T inhA_c.-547C>T 1 upstream_gene_variant 1673655 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1166 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide inhA c.549T>A inhA_c.549T>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide inhA c.-552G>A inhA_c.-552G>A 1 upstream_gene_variant 1673650 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide inhA c.555T>C inhA_c.555T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide inhA c.567T>G inhA_c.567T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide inhA c.-602G>A inhA_c.-602G>A 1 upstream_gene_variant 1673600 1 1 0 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 115.699581334225 1 815 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide inhA c.603G>C inhA_c.603G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide inhA c.615T>C inhA_c.615T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide inhA c.-616C>T inhA_c.-616C>T 1 upstream_gene_variant 1673586 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide inhA c.-631C>T inhA_c.-631C>T 1 upstream_gene_variant 1673571 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide inhA c.636C>T inhA_c.636C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide inhA c.-636G>A inhA_c.-636G>A 1 upstream_gene_variant 1673566 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide inhA c.648G>A inhA_c.648G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide inhA c.649C>T inhA_c.649C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide inhA c.663C>T inhA_c.663C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide inhA c.-67C>T inhA_c.-67C>T 1 upstream_gene_variant 1674135 1 7 1 6 4 8 5208 15479 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.99948343772196 0.998982421476308 0.999776959534822 0.333333333333333 0.0992460911495833 0.651124493581186 0.142857142857142 0.00361029686190058 0.578723197043195 0.111111111111111 0.00280913674659921 0.482496514917337 0.495359703020993 0.010770969402106 4.08451580207892 0.687787823497333 477 2233 False False 1.48607910906298 0.327343181309975 5.54928881094045 0.000191975427145325 4.860385190457e-06 0.00106914936617667 0.99948343772196 0.998982421476308 0.999776959534822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 2169 3788 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999472295514512 0.998095063429584 0.999936086148442 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 68.0572464902929 1 405 1065 False False 0 0 0 0 0 0 0 0.87321346242508 0.0147995228023146 16.7833115850342 0 0 0.0016992827759538 0.999472295514512 0.998095063429584 0.999936086148442 11 3) Uncertain significance No change no 1 +Ethionamide inhA c.684C>T inhA_c.684C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.19247409791798 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide inhA c.-688G>A inhA_c.-688G>A 1 upstream_gene_variant 1673514 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide inhA c.-700C>T inhA_c.-700C>T 1 upstream_gene_variant 1673502 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1141 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide inhA c.-705G>A inhA_c.-705G>A 1 upstream_gene_variant 1673497 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Ethionamide inhA c.-706G>A inhA_c.-706G>A 1 upstream_gene_variant 1673496 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1170 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 536 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 1 3) Uncertain significance New Uncertain no 0 +Ethionamide inhA c.714C>A inhA_c.714C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide inhA c.-715T>C inhA_c.-715T>C 1 upstream_gene_variant 1673487 1 1 0 1 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 115.669966941234 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 517 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 2 3) Uncertain significance New Uncertain no 0 +Ethionamide inhA c.726G>A inhA_c.726G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide inhA c.-728C>G inhA_c.-728C>G 1 upstream_gene_variant 1673474 1 5 1 4 3 4 5209 15483 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.99974171886098 0.999338830952079 0.999929622742193 0.428571428571428 0.0989882784425078 0.815948432359917 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 0.743088884622768 0.0150900426402587 7.51277951563208 1 496.5 2233 False False 2.2292666538683 0.326438409930677 13.182222747906 0.00019193857965451 4.85945229729366e-06 0.00106894424519385 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 3) Uncertain significance No change no 1 +Ethionamide inhA c.-730C>T inhA_c.-730C>T 1 upstream_gene_variant 1673472 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide inhA c.732G>A inhA_c.732G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0761899451219867 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide inhA c.-734A>G inhA_c.-734A>G 1 upstream_gene_variant 1673468 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide inhA c.738G>A inhA_c.738G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide inhA c.-752C>G inhA_c.-752C>G 1 upstream_gene_variant 1673450 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1178 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 541 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide inhA c.-752C>T inhA_c.-752C>T 1 upstream_gene_variant 1673450 1 5 1 4 1 4 5211 15483 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99974171886098 0.999338830952079 0.999929622742193 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 0.742803684513529 0.0150842538989179 7.50989306640636 1 815 2233 False False 0.742803684513529 0.0150842538989179 7.50989306640636 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 7 3) Uncertain significance No change no 1 +Ethionamide inhA c.75C>A inhA_c.75C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.2999762698034 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide inhA c.-764G>A inhA_c.-764G>A 1 upstream_gene_variant 1673438 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethionamide inhA c.-766C>A inhA_c.-766C>A 1 upstream_gene_variant 1673436 2 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 3) Uncertain significance New Uncertain no 0 +Ethionamide inhA c.-767T>C inhA_c.-767T>C 1 upstream_gene_variant 1673435 0 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1171 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 537 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0 0 0.00170006591133688 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide inhA c.-770T>A inhA_c.-770T>A 1 upstream_gene_variant 1673432 1 9 3 6 64 20 5148 15467 0.0122793553338449 0.00946909016043202 0.0156537482722407 0.9987085943049 0.998006229813624 0.999211003011252 0.761904761904761 0.656510536260659 0.848093719945216 0.333333333333333 0.0748546314196918 0.700704943791459 0.130434782608695 0.0277515074227932 0.335889137537121 1.50223387723387 0.243001203442086 7.03682952968211 0.699506188560585 480 2233 False False 9.61429681429681 5.73579818323632 16.7950462755138 0.0005824111822947 0.000120123295662517 0.00170110001322063 0.9987085943049 0.998006229813624 0.999211003011252 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 2 2 8 5 2162 3785 0.00368663594470046 0.00159293019145598 0.00725115327762171 0.998680738786279 0.996923992057454 0.999571505100005 0.615384615384615 0.315777602914063 0.861420661109839 0.5 0.067585986488543 0.932414013511457 0.285714285714285 0.0366925661760855 0.709579136262657 1.75069380203515 0.12679061198722 24.17217925024 0.625081214446302 276 1065 False False 0 0 0 0 0 0 0 2.80111008325624 0.806655041319276 10.8938792541651 0.000924214417744916 0.000111946257485536 0.00333455240606835 0.998680738786279 0.996923992057454 0.999571505100005 158 Assoc w RI Marker of R WHO-endorsed gDST assay 2) Assoc w R - Interim Alias fabG1_c.-8T>A No change yes WHO-end. gDST I 1 +Ethionamide inhA c.-770T>C inhA_c.-770T>C 1 upstream_gene_variant 1673432 1 26 9 17 186 164 5026 15323 0.0356868764389869 0.0308161824677721 0.041085995709825 0.989410473300187 0.987670823305089 0.990962408200048 0.531428571428571 0.477645050125461 0.584675975872874 0.346153846153846 0.172144138005666 0.55667192604239 0.0520231213872832 0.0240611351616775 0.0964565919471842 1.61404227429133 0.633505712326662 3.83097663762085 0.256115454246975 334 2233 False False 3.45772470955907 2.78057239696513 4.30242454287401 0.00178748758689175 0.000817668679558365 0.00339048430108125 0.989410473300187 0.987670823305089 0.990962408200048 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 3 4 75 65 2095 3725 0.0345622119815668 0.0272804521315503 0.043133185262319 0.982849604221636 0.978192016128404 0.98673939131756 0.535714285714285 0.449540644204989 0.620344949811692 0.428571428571428 0.0989882784425078 0.815948432359917 0.0441176470588235 0.00919219520278738 0.123562624331778 1.3335322195704 0.195145223870607 7.89184736625567 0.707671854393956 283 1065 False False 0 0 0 0 0 0 0 2.05158803010831 1.44517467025137 2.91815859835252 0.00142993326978074 0.000294983749851961 0.00417313153029698 0.982849604221636 0.978192016128404 0.98673939131756 112 Assoc w RI Marker of R WHO-endorsed gDST assay 2) Assoc w R - Interim Alias fabG1_c.-8T>C No change yes WHO-end. gDST J 1 +Ethionamide inhA c.-770T>G inhA_c.-770T>G 1 upstream_gene_variant 1673432 1 3 2 1 11 1 5201 15486 0.0021105141980046 0.00105401717787221 0.00377314786388412 0.999935429715245 0.999640290494779 0.999998365223265 0.916666666666666 0.615203834849055 0.997892406768139 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 5.95500865218227 0.309917883836641 350.553145630208 0.157898095231856 159 2233 False False 32.7525475870024 4.75807868864481 1399.79305488175 0.000384393619065923 4.6555241067454e-05 0.00138786491955537 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 525 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 9 INH-ETO cross-resistance 2) Assoc w R - Interim Alias fabG1_c.-8T>G UP from Uncertain to AwRI yes INH-ETH X-R K 4 +Ethionamide inhA c.-771G>A inhA_c.-771G>A 1 upstream_gene_variant 1673431 1 2 0 2 1 3 5211 15484 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999806289145735 0.999434000080036 0.999960050383188 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 15.825310980719 1 815 2233 False False 0.990468879933474 0.0188633706776044 12.3373543450537 0 0 0.000707651905360176 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Ethionamide inhA c.777C>T inhA_c.777C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide inhA c.-777C>T inhA_c.-777C>T 1 upstream_gene_variant 1673425 1 1434 939 495 2166 745 3046 14742 0.415579432079815 0.402154552247415 0.429098934739929 0.951895137857558 0.948406796480786 0.955212453308546 0.744074201305393 0.727809777947729 0.75984658159852 0.654811715481171 0.629558288075844 0.679429196911425 0.557600950118764 0.533499216097864 0.581501591466963 9.1809347579538 8.16487317201835 10.3288899222422 0 1 2233 True False 14.0711206687613 12.8241852539542 15.4448633561313 0.235633626097867 0.222529169206447 0.249126788903333 0.951895137857558 0.948406796480786 0.955212453308546 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 478 305 173 906 338 1264 3452 0.417511520737327 0.396655417748371 0.438590742041091 0.910817941952506 0.90129250646168 0.919704155678108 0.728295819935691 0.702654071289621 0.752853802088301 0.638075313807531 0.59319935396765 0.681231269689512 0.474339035769828 0.43515988976348 0.513754768260031 4.81479110265603 3.93544361032117 5.89980224558074 3.06503368207662e-57 3 1065 True False 0 0 0 0 0 0 0 7.32040671110778 6.34800731277142 8.44939902186405 0.194391332058636 0.175077703463269 0.214855530630583 0.910817941952506 0.90129250646168 0.919704155678108 2348 Assoc w R Marker of R 1) Assoc w R Alias fabG1_c.-15C>T No change yes L 1 +Ethionamide inhA c.-778A>G inhA_c.-778A>G 1 upstream_gene_variant 1673424 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1164 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Assoc w RI Marker of R WHO-endorsed gDST assay 2) Assoc w R - Interim Alias fabG1_c.-16A>G no change yes WHO-end. gDST M 1 +Ethionamide inhA c.-779G>T inhA_c.-779G>T 1 upstream_gene_variant 1673423 1 61 7 54 122 139 5090 15348 0.0234075211051419 0.0194755121275618 0.0278848860416222 0.991024730419061 0.989411156398639 0.992449564795481 0.46743295019157 0.405660977183976 0.529952806990139 0.114754098360655 0.0474022571464175 0.222249208536497 0.047945205479452 0.0194910086404923 0.0962891497881954 0.390875354726042 0.149983948228451 0.86243769074865 0.0165283315976338 83 2233 False False 2.64654351175248 2.05352604672703 3.40670829676003 0.00137335687659407 0.000552333341151018 0.00282758003274104 0.991024730419061 0.989411156398639 0.992449564795481 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 4 3 20 6 2150 3784 0.00921658986175115 0.00563856234802832 0.0141985462722211 0.998416886543535 0.996557436795264 0.999418810659556 0.769230769230769 0.563524903058613 0.910259889115424 0.571428571428571 0.184051567640083 0.901011721557492 0.4 0.121552258119827 0.737621923393055 2.34666666666666 0.396540838126657 16.0354287621201 0.263619737236914 80 1065 False False 0 0 0 0 0 0 0 5.86666666666666 2.2671794465996 17.8731786289792 0.00185701021355617 0.000506197298913578 0.00474779872787239 0.998416886543535 0.996557436795264 0.999418810659556 287 INH-ETO cross-resistance 2) Assoc w R - Interim Alias fabG1_c.-17G>T UP from Uncertain to AwRI yes INH-ETH X-R N 4 +Ethionamide inhA c.-781G>T inhA_c.-781G>T 1 upstream_gene_variant 1673421 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide inhA c.-782C>T inhA_c.-782C>T 1 upstream_gene_variant 1673420 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1152 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide inhA c.783C>T inhA_c.783C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide inhA c.786C>A inhA_c.786C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 6 5211 15481 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99961257829147 0.999156938222445 0.999857810215121 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.495138489093584 0.0107661625367428 4.08269117192464 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide inhA c.-789G>C inhA_c.-789G>C 1 upstream_gene_variant 1673413 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 3 3) Uncertain significance No change no 1 +Ethionamide inhA c.-792C>T inhA_c.-792C>T 1 upstream_gene_variant 1673410 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1128 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide inhA c.-794G>T inhA_c.-794G>T 1 upstream_gene_variant 1673408 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1136 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide inhA c.-796C>G inhA_c.-796C>G 1 upstream_gene_variant 1673406 1 3 1 2 6 2 5206 15485 0.00115118956254796 0.000422579736688136 0.00250395844332671 0.99987085943049 0.99953357854254 0.999984360095269 0.75 0.349144205587175 0.968145973750055 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 1.48722627737226 0.0252035702595515 28.5799676559641 1 815 2233 False False 8.92335766423357 1.59482419691585 90.4879132424694 0.000192049164586134 4.86225205174921e-06 0.00106955984439844 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 68.0751891811639 1 405 1065 False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 0 0 0.0016992827759538 0.999736147757256 0.998530795728906 0.999993319861894 5 3) Uncertain significance No change no 1 +Ethionamide inhA c.-796C>T inhA_c.-796C>T 1 upstream_gene_variant 1673406 1 3 1 2 12 7 5200 15480 0.00230237912509593 0.00119022113901414 0.0040183355622907 0.999548008006715 0.999068946905294 0.99981825708278 0.631578947368421 0.383577923314405 0.8371141278449 0.333333333333333 0.00840375865961264 0.905700675949754 0.125 0.0031597235312519 0.526509670875206 1.48846153846153 0.0252244984419113 28.6036308082501 1 815 2233 False False 5.1032967032967 1.85120631004973 15.3088627140423 0.000192270717169775 4.86786125023104e-06 0.00107079317238176 0.999548008006715 0.999068946905294 0.99981825708278 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 9 4 2161 3786 0.00414746543778801 0.00189818564765315 0.00785851894409672 0.998944591029023 0.997299958285064 0.999712364080324 0.692307692307692 0.385738338249294 0.909079605427903 0.333333333333333 0.00840375865961264 0.905700675949754 0.2 0.00505076337946806 0.716417936118089 0.875983341045812 0.0148464237906481 16.8365588108444 1 405 1065 False False 0 0 0 0 0 0 0 3.94192503470615 1.09832912339552 17.5279190881337 0.000462534690101757 1.17102959040189e-05 0.00257435532747442 0.998944591029023 0.997299958285064 0.999712364080324 18 3) Uncertain significance No change no 1 +Ethionamide inhA c.-796delC inhA_c.-796delC 1 upstream_gene_variant 1673405 1 2 0 2 7 2 5205 15485 0.00134305448963929 0.000540142673187124 0.00276523543039201 0.99987085943049 0.99953357854254 0.999984360095269 0.777777777777777 0.399906426283687 0.971855026522101 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8445676397064 1 815 2233 False False 10.4125840537944 1.98148385005314 102.77996933635 0 0 0.000708467353397108 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 518 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0 0 0.00170006591133688 1 0.999027154404229 1 3 3) Uncertain significance No change no 1 +Ethionamide inhA c.-800_-787delATTTCGGCCCGGCC inhA_c.-800_-787delATTTCGGCCCGGCC 1 upstream_gene_variant 1673401 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1148 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide inhA c.-801G>A inhA_c.-801G>A 1 upstream_gene_variant 1673401 1 3 0 3 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 7.19247409791798 0.577090863007554 439 2233 False False 0 0 7.19247409791798 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 25 3) Uncertain significance No change no 1 +Ethionamide inhA c.-807C>G inhA_c.-807C>G 1 upstream_gene_variant 1673395 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1174 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 539 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide inhA c.-809G>A inhA_c.-809G>A 1 upstream_gene_variant 1673393 1 20 1 19 1 19 5211 15468 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.998773164589655 0.998084804605634 0.999261208414407 0.05 0.0012650894979498 0.248732762772027 0.05 0.0012650894979498 0.248732762772027 0.05 0.0012650894979498 0.248732762772027 0.156228221676817 0.00376307557127773 0.983299812298748 0.0378700330449564 92 2233 False False 0.156228221676817 0.00376307557127773 0.983299812298748 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.998773164589655 0.998084804605634 0.999261208414407 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 18 0 18 0 18 2170 3772 0 0 0.00169850036174098 0.995250659630606 0.992504342430345 0.997182884315989 0 0 0.185301968137852 0 0 0.185301968137852 0 0 0.185301968137852 0 0 0.395898830848114 0.00034469052180431 15 1065 True False 0 0 0 0 0 0 0 0 0 0.395898830848114 0 0 0.00169850036174098 0.995250659630606 0.992504342430345 0.997182884315989 8 3) Uncertain significance New Uncertain no 0 +Ethionamide inhA c.-809G>C inhA_c.-809G>C 1 upstream_gene_variant 1673393 1 14 1 13 1 15 5211 15472 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999031445728675 0.998403019382043 0.999457809400789 0.0625 0.00158111172276588 0.302320738434531 0.0714285714285714 0.00180678065912538 0.338684489931821 0.0625 0.00158111172276588 0.302320738434531 0.228392601449596 0.00537692507538008 1.52133334851373 0.213125267067774 188 2233 False False 0.19794025458965 0.0047047775576851 1.28724837065904 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999031445728675 0.998403019382043 0.999457809400789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.74688796680497 0.0222439624669857 137.016358245527 1 405 1065 False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 56 3) Uncertain significance No change no 1 +Ethionamide inhA c.-88T>A inhA_c.-88T>A 1 upstream_gene_variant 1674114 0 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1133 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide inhA c.-93C>T inhA_c.-93C>T 1 upstream_gene_variant 1674109 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide inhA c.-94C>T inhA_c.-94C>T 1 upstream_gene_variant 1674108 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide inhA c.99C>A inhA_c.99C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide inhA c.9A>C inhA_c.9A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 5 127 5207 15360 0.000959324635456638 0.000311561141138009 0.0022373118395626 0.99179957383612 0.990250653398216 0.993159220877113 0.0378787878787878 0.0124116283076792 0.0861820016268626 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.116136817639488 0.0370498041006071 0.278445522429589 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 2 5 2168 3785 0.000921658986175115 0.000111636674590768 0.0033253435449308 0.998680738786279 0.996923992057454 0.999571505100005 0.285714285714285 0.0366925661760855 0.709579136262657 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.698339483394834 0.0664358722176252 4.27020900106932 NA NA NA NA NA NA 243 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide inhA p.Ala114Thr inhA_p.Ala114Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 115.699581334225 1 815 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 68.0751891811639 1 405 1065 False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 0 0 0.0016992827759538 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide inhA p.Ala124Val inhA_p.Ala124Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1168 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide inhA p.Ala133Thr inhA_p.Ala133Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 7.19247409791798 0.577090863007554 439 2233 False False 0 0 7.19247409791798 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.2999762698034 0.53686319604546 244.5 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 NA 3) Uncertain significance No change no 1 +Ethionamide inhA p.Ala190Ser inhA_p.Ala190Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance No change no 1 +Ethionamide inhA p.Ala201Thr inhA_p.Ala201Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide inhA p.Ala22Ser inhA_p.Ala22Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1162 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 533 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 1 3) Uncertain significance No change no 1 +Ethionamide inhA p.Ala235Thr inhA_p.Ala235Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1153 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 530 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide inhA p.Ala235Val inhA_p.Ala235Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1142 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide inhA p.Ala239Thr inhA_p.Ala239Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1137 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 521 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide inhA p.Ala239Val inhA_p.Ala239Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 15 0 5197 15487 0.00287797390636991 0.0016116471700824 0.00474234467149281 1 0.999761836368682 1 1 0.781980639089466 1 NA NA NA NA NA NA NA NA NA NA 1150 2233 False False Inf 10.6826468306471 Inf 0 0 0.000709557545345995 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 6 0 2164 3790 0.00276497695852534 0.00101535276242503 0.00600840604626057 1 0.999027154404229 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 527 1065 False False 0 0 0 0 0 0 0 Inf 2.05945731043461 Inf 0 0 0.00170320568455034 1 0.999027154404229 1 7 3) Uncertain significance No change no 1 +Ethionamide inhA p.Ala84Thr inhA_p.Ala84Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1149 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide inhA p.Arg27Trp inhA_p.Arg27Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide inhA p.Asn231Asp inhA_p.Asn231Asp 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 3 3) Uncertain significance New Uncertain no 0 +Ethionamide inhA p.Asn231Lys inhA_p.Asn231Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide inhA p.Asp248Asn inhA_p.Asp248Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethionamide inhA p.Asp52Gly inhA_p.Asp52Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1134 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide inhA p.Asp89Asn inhA_p.Asp89Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide inhA p.Gln35Arg inhA_p.Gln35Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1159 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 532 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 18 3) Uncertain significance No change no 1 +Ethionamide inhA p.Glu209Gly inhA_p.Glu209Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide inhA p.Glu80Ala inhA_p.Glu80Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide inhA p.Gly212Ser inhA_p.Gly212Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide inhA p.Gly221Ser inhA_p.Gly221Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide inhA p.Gly40Trp inhA_p.Gly40Trp 1 missense_variant (see "Genomic_coordinates" sheet) 2 2 1 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 2.97179044329303 0.0378514560716107 232.854636669753 0.440205269357083 400.5 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 528 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 1 3) Uncertain significance No change no 1 +Ethionamide inhA p.Gly76Asp inhA_p.Gly76Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1138 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 522 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide inhA p.Gly76Ser inhA_p.Gly76Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide inhA p.Gly83Arg inhA_p.Gly83Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 5212 15483 0 0 0.000707516179821284 0.99974171886098 0.999338830952079 0.999929622742193 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 4.5014696306354 0.578098957200874 462.5 2233 False False 0 0 4.5014696306354 0 0 0.000707516179821284 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 2170 3787 0 0 0.00169850036174098 0.999208443271767 0.997688494809834 0.999836732216022 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.22663965322398 0.558201069943668 269 1065 False False 0 0 0 0 0 0 0 0 0 4.22663965322398 0 0 0.00169850036174098 0.999208443271767 0.997688494809834 0.999836732216022 3 3) Uncertain significance No change no 1 +Ethionamide inhA p.Ile16Thr inhA_p.Ile16Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 5210 15486 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 115.721748393509 1 815 2233 False False 5.9447216890595 0.309382652589367 349.949104522224 0 0 0.000707787682982558 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 526 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide inhA p.Ile194Thr inhA_p.Ile194Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 123 6 5089 15481 0.0235993860322333 0.0196508803329039 0.0280929648373902 0.99961257829147 0.999156938222445 0.999857810215121 0.953488372093023 0.901512826211628 0.982742285679976 0 0 0.975 0 0 0.4592581264399 0 0 118.429968167212 1 815 2233 False False 62.3620554136372 27.8079164767528 173.422819306479 0 0 0.000724610491701878 0.99961257829147 0.999156938222445 0.999857810215121 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 0 1 48 3 2122 3787 0.0221198156682027 0.0163533614937307 0.0292216620167955 0.999208443271767 0.997688494809834 0.999836732216022 0.941176470588235 0.837577781927949 0.98770091174476 0 0 0.975 0 0 0.707598226178713 0 0 69.5446630655853 1 405 1065 False False 0 0 0 0 0 0 0 28.5541941564561 9.18298130475357 143.507126097239 0 0 0.00173688734303173 0.999208443271767 0.997688494809834 0.999836732216022 241 3) Uncertain significance No change no 1 +Ethionamide inhA p.Ile21Met inhA_p.Ile21Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1129 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 516 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 1 3) Uncertain significance New Uncertain no 0 +Ethionamide inhA p.Ile21Thr inhA_p.Ile21Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 110 16 5102 15471 0.021105141980046 0.017377006490642 0.0253820978901805 0.99896687544392 0.998322811196946 0.999409368388177 0.873015873015873 0.80198911878452 0.925643383617712 0.5 0.012579117093425 0.987420882906574 0.0588235294117647 0.00148817439126663 0.28688939666722 3.03234025872206 0.0386225199687882 237.589227634011 0.434534304111135 373 2233 False False 20.8473392787142 12.2664671084176 37.7387447937342 0.000195963158926121 4.96134532217202e-06 0.0010913478909143 0.99896687544392 0.998322811196946 0.999409368388177 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 23 6 2147 3784 0.0105990783410138 0.00673043866200777 0.015861607755458 0.998416886543535 0.996557436795264 0.999418810659556 0.793103448275862 0.60275305077276 0.92005815112392 1 0.025 1 0.142857142857142 0.00361029686190058 0.578723197043195 Inf 0.0451700268352359 Inf 0.36210384356035 103 1065 False False 0 0 0 0 0 0 0 6.75609377425865 2.66797976254525 20.3079596178679 0.000465549348230912 1.17866195429756e-05 0.00259111632710752 0.998416886543535 0.996557436795264 0.999418810659556 58 3) Uncertain significance No change no 1 +Ethionamide inhA p.Ile21Val inhA_p.Ile21Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 30 7 5182 15480 0.00575594781273983 0.00388678380786634 0.00820685679375776 0.999548008006715 0.999068946905294 0.99981825708278 0.81081081081081 0.648447621630745 0.920378879147123 0.5 0.012579117093425 0.987420882906574 0.125 0.0031597235312519 0.526509670875206 2.98726360478579 0.0380484966858561 234.064574990986 0.438742447448948 374 2233 False False 12.8025583062248 5.50533273511524 34.5305114452526 0.000192938452633609 4.88476676605171e-06 0.00107451028163508 0.999548008006715 0.999068946905294 0.99981825708278 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 0 1 17 2 2153 3788 0.00783410138248848 0.00457008300677052 0.0125136142049884 0.999472295514512 0.998095063429584 0.999936086148442 0.894736842105263 0.668623335543234 0.986987835628222 0 0 0.975 0 0 0.841886116991581 0 0 68.562471478955 1 405 1065 False False 0 0 0 0 0 0 0 14.9549465861588 3.54321765114705 133.783044581333 0 0 0.00171190016524938 0.999472295514512 0.998095063429584 0.999936086148442 35 3) Uncertain significance No change no 1 +Ethionamide inhA p.Ile228Val inhA_p.Ile228Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 9 5212 15478 0 0 0.000707516179821284 0.999418867437205 0.998897117312968 0.999734235852573 0 0 0.336267116879942 0 0 0.409616397225003 0 0 0.336267116879942 0 0 2.06120450429687 0.203401694775548 182 2233 False False 0 0 1.50519575721189 0 0 0.000707516179821284 0.999418867437205 0.998897117312968 0.999734235852573 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.2999762698034 0.53686319604546 244.5 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 34 3) Uncertain significance No change no 1 +Ethionamide inhA p.Ile95Leu inhA_p.Ile95Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1135 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 520 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 2 3) Uncertain significance No change no 1 +Ethionamide inhA p.Ile95Val inhA_p.Ile95Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1172 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethionamide inhA p.Lys233Thr inhA_p.Lys233Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1179 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 542 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide inhA p.Met130Val inhA_p.Met130Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1180 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 543 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide inhA p.Met161Val inhA_p.Met161Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1154 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide inhA p.Phe41Ser inhA_p.Phe41Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1143 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide inhA p.Pro107Ser inhA_p.Pro107Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1144 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide inhA p.Ser94Ala inhA_p.Ser94Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 28 17 11 118 24 5094 15463 0.0226400613967766 0.0187747722433717 0.0270518464231909 0.998450313165881 0.997695060668636 0.999006841908059 0.830985915492957 0.759038802833922 0.888605192003809 0.607142857142857 0.405768206487563 0.784957170839039 0.414634146341463 0.263167994688662 0.57890385728767 4.69127672484562 2.07104725158286 11.0886982547569 5.91207026109916e-05 30 2233 True False 14.9246989922784 9.5479466883968 24.240383446298 0.00332615926433183 0.00193876749014402 0.00532017884264175 0.998450313165881 0.997695060668636 0.999006841908059 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance 1 8 4 4 50 8 2120 3782 0.0230414746543778 0.0171490447487957 0.0302655431159548 0.997889182058047 0.995845105987758 0.999088271930771 0.862068965517241 0.746190244723521 0.938520337034264 0.5 0.157012770487058 0.842987229512941 0.333333333333333 0.0992460911495833 0.651124493581186 1.78396226415094 0.331897208684845 9.58740364346889 0.469333513766448 222 1065 False False 0 0 0 0 0 0 0 11.1497641509433 5.22961031842759 27.2578073992493 0.00188323917137476 0.000513350196700463 0.0048147594682355 0.997889182058047 0.995845105987758 0.999088271930771 129 Assoc w RI Evidence from ALL dataset only 2) Assoc w R - Interim No change yes ALL only 1 +Ethionamide inhA p.Thr162Met inhA_p.Thr162Met 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1132 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 519 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide inhA p.Thr162Ser inhA_p.Thr162Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 16 5210 15471 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.99896687544392 0.998322811196946 0.999409368388177 0.111111111111111 0.0137512156643644 0.347120438608672 NA NA NA 0 0 0.205907214207822 NA NA NA NA 1158 2233 False False 0.371185220729366 0.0413928523902508 1.57969796674415 0 0 0.000707787682982558 0.99896687544392 0.998322811196946 0.999409368388177 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 38 3) Uncertain significance No change no 1 +Ethionamide inhA p.Thr236Met inhA_p.Thr236Met 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 4 5208 15483 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.99974171886098 0.999338830952079 0.999929622742193 0.5 0.157012770487058 0.842987229512941 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1139 2233 False False 2.9729262672811 0.553517542355507 15.9639231757182 0 0 0.000708059394597755 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 4 2167 3786 0.00138248847926267 0.000285193152965682 0.0040348522148252 0.998944591029023 0.997299958285064 0.999712364080324 0.428571428571428 0.0989882784425078 0.815948432359917 NA NA NA 0 0 0.602364635616474 NA NA NA NA 523 1065 False False 0 0 0 0 0 0 0 1.31033687125057 0.191756392649407 7.7545860694147 0 0 0.00170084976888778 0.998944591029023 0.997299958285064 0.999712364080324 2 3) Uncertain significance No change no 1 +Ethionamide inhA p.Thr2Pro inhA_p.Thr2Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1155 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 531 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide inhA p.Thr51Ala inhA_p.Thr51Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide inhA p.Tyr182His inhA_p.Tyr182His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide inhA p.Val171Ile inhA_p.Val171Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1160 2233 False False 0 0 7.19247409791798 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide inhA p.Val203Ala inhA_p.Val203Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide inhA p.Val78Ala inhA_p.Val78Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 10 5212 15477 0 0 0.000707516179821284 0.99935429715245 0.998812851129914 0.999690318343011 0 0 0.30849710781876 NA NA NA 0 0 0.30849710781876 NA NA NA NA 1147 2233 False False 0 0 1.32532562767373 0 0 0.000707516179821284 0.99935429715245 0.998812851129914 0.999690318343011 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 63 3) Uncertain significance No change no 1 +Ethionamide inhA p.Val91Ala inhA_p.Val91Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide inhA p.Val92Met inhA_p.Val92Met 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1145 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA c.1026G>A mshA_c.1026G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.1035G>A mshA_c.1035G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.1053C>T mshA_c.1053C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 3 16 5209 15471 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.99896687544392 0.998322811196946 0.999409368388177 0.157894736842105 0.0338262490017646 0.395784551266674 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.556884718755999 0.103933226802786 1.94663907613303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 4 2169 3786 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.998944591029023 0.997299958285064 0.999712364080324 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.436376210235131 0.00886124548211645 4.41391975850517 NA NA NA NA NA NA 13 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.1056C>T mshA_c.1056C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.1080G>T mshA_c.1080G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.-108G>A mshA_c.-108G>A 1 upstream_gene_variant 575240 1 6 0 6 0 6 5212 15481 0 0 0.000707516179821284 0.99961257829147 0.999156938222445 0.999857810215121 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 2.52357746319564 0.347651033317578 363.5 2233 False False 0 0 2.52357746319564 0 0 0.000707516179821284 0.99961257829147 0.999156938222445 0.999857810215121 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 2170 3786 0 0 0.00169850036174098 0.998944591029023 0.997299958285064 0.999712364080324 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.6454264678615 0.303692649321994 95 1065 False False 0 0 0 0 0 0 0 0 0 2.6454264678615 0 0 0.00169850036174098 0.998944591029023 0.997299958285064 0.999712364080324 8 3) Uncertain significance No change no 1 +Ethionamide mshA c.1092G>A mshA_c.1092G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.19247409791798 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.1104G>A mshA_c.1104G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.1116G>A mshA_c.1116G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.1116G>T mshA_c.1116G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.-111C>T mshA_c.-111C>T 1 upstream_gene_variant 575237 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA c.1125C>T mshA_c.1125C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.-114T>C mshA_c.-114T>C 1 upstream_gene_variant 575234 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1408 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethionamide mshA c.1161C>A mshA_c.1161C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 5 5 5207 15482 0.000959324635456638 0.000311561141138009 0.0022373118395626 0.999677148576225 0.999246734667469 0.999895162977301 0.5 0.187086028447398 0.812913971552601 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.97330516612252 0.683933954548825 12.9208342947657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.1173C>T mshA_c.1173C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 0 NA NA NA 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0761899451219867 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.117G>T mshA_c.117G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.-120A>T mshA_c.-120A>T 1 upstream_gene_variant 575228 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA c.1216C>T mshA_c.1216C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.55810577429468 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.1227T>C mshA_c.1227T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 10 5212 15477 0 0 0.000707516179821284 0.99935429715245 0.998812851129914 0.999690318343011 0 0 0.30849710781876 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.32532562767373 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 2170 3786 0 0 0.00169850036174098 0.998944591029023 0.997299958285064 0.999712364080324 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.6454264678615 NA NA NA NA NA NA 14 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.1245G>A mshA_c.1245G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 5212 15482 0 0 0.000707516179821284 0.999677148576225 0.999246734667469 0.999895162977301 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.24289311550326 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 5 2170 3785 0 0 0.00169850036174098 0.998680738786279 0.996923992057454 0.999571505100005 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.90544972133019 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.-125G>A mshA_c.-125G>A 1 upstream_gene_variant 575223 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1431 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA c.1260G>T mshA_c.1260G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.1278C>T mshA_c.1278C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.1302C>T mshA_c.1302C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0761899451219867 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.1317C>T mshA_c.1317C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.-132C>A mshA_c.-132C>A 1 upstream_gene_variant 575216 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1436 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 716 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 7 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA c.132G>A mshA_c.132G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 5212 15483 0 0 0.000707516179821284 0.99974171886098 0.999338830952079 0.999929622742193 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.5014696306354 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 2170 3787 0 0 0.00169850036174098 0.999208443271767 0.997688494809834 0.999836732216022 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.22663965322398 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.1347C>T mshA_c.1347C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.1365G>C mshA_c.1365G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.97179044329303 0.0378514560716107 232.854636669753 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.1368C>T mshA_c.1368C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0761899451219867 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.-136G>C mshA_c.-136G>C 1 upstream_gene_variant 575212 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1495 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA c.1383G>A mshA_c.1383G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.2999762698034 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.1410C>G mshA_c.1410C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.1419G>A mshA_c.1419G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.19247409791798 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.1425T>C mshA_c.1425T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.-146T>G mshA_c.-146T>G 1 upstream_gene_variant 575202 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA c.-152A>G mshA_c.-152A>G 1 upstream_gene_variant 575196 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA c.-153C>T mshA_c.-153C>T 1 upstream_gene_variant 575195 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA c.-156A>G mshA_c.-156A>G 1 upstream_gene_variant 575192 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA c.169C>T mshA_c.169C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.-172_-171insG mshA_c.-172_-171insG 1 upstream_gene_variant 575176 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1509 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA c.174A>G mshA_c.174A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.-175G>A mshA_c.-175G>A 1 upstream_gene_variant 575173 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1472 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA c.-181G>C mshA_c.-181G>C 1 upstream_gene_variant 575167 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA c.-183C>T mshA_c.-183C>T 1 upstream_gene_variant 575165 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1504 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethionamide mshA c.192C>T mshA_c.192C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.-195C>A mshA_c.-195C>A 1 upstream_gene_variant 575153 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1410 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 702 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA c.-202A>C mshA_c.-202A>C 1 upstream_gene_variant 575146 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA c.219G>A mshA_c.219G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.-219G>C mshA_c.-219G>C 1 upstream_gene_variant 575129 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA c.21T>C mshA_c.21T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 25 79 5187 15408 0.00479662317728319 0.00310645477745336 0.00707267229851305 0.994898947504358 0.99364656352762 0.995959430278262 0.240384615384615 0.162002310865132 0.334078615818004 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.940032652224524 0.573602180376836 1.49213996192945 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 18 28 2152 3762 0.00829493087557603 0.00492329693497667 0.0130779973003701 0.992612137203166 0.989340055471718 0.995085367804224 0.391304347826087 0.250879411560762 0.546258620587539 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.12380509824747 0.583943031578108 2.11026624664477 NA NA NA NA NA NA 826 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.-222G>T mshA_c.-222G>T 1 upstream_gene_variant 575126 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 2 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA c.-229C>G mshA_c.-229C>G 1 upstream_gene_variant 575119 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1482 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA c.229C>T mshA_c.229C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 8 5212 15479 0 0 0.000707516179821284 0.99948343772196 0.998982421476308 0.999776959534822 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.74050626415467 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 8 2170 3782 0 0 0.00169850036174098 0.997889182058047 0.995845105987758 0.999088271930771 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.02226055754074 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.231G>C mshA_c.231G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 41 5212 15446 0 0 0.000707516179821284 0.997352618325046 0.996410223701187 0.998099543820555 0 0 0.0860438362940284 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.279143994395056 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 35 2170 3755 0 0 0.00169850036174098 0.990765171503957 0.987179785497929 0.993559412395983 0 0 0.100032435572105 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.192649082876315 NA NA NA NA NA NA 17 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.-23G>A mshA_c.-23G>A 1 upstream_gene_variant 575325 1 1 0 1 1 3 5211 15484 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999806289145735 0.999434000080036 0.999960050383188 0.25 0.00630946320970987 0.805879550316756 0 0 0.975 0 0 0.707598226178713 0 0 115.684666832268 1 496.5 2233 False False 0.990468879933474 0.0188633706776044 12.3373543450537 0 0 0.000707651905360176 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA c.-241A>C mshA_c.-241A>C 1 upstream_gene_variant 575107 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA c.-254A>C mshA_c.-254A>C 1 upstream_gene_variant 575094 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA c.-254A>G mshA_c.-254A>G 1 upstream_gene_variant 575094 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1463 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 727 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA c.-257G>A mshA_c.-257G>A 1 upstream_gene_variant 575091 1 1 0 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 115.699581334225 1 815 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 703 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 1 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA c.264C>T mshA_c.264C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.-268A>G mshA_c.-268A>G 1 upstream_gene_variant 575080 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1448 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 721 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 6 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA c.270C>T mshA_c.270C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.-28C>G mshA_c.-28C>G 1 upstream_gene_variant 575320 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA c.-297A>G mshA_c.-297A>G 1 upstream_gene_variant 575051 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA c.297G>T mshA_c.297G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.-29C>T mshA_c.-29C>T 1 upstream_gene_variant 575319 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA c.-2G>A mshA_c.-2G>A 1 upstream_gene_variant 575346 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide mshA c.-301A>G mshA_c.-301A>G 1 upstream_gene_variant 575047 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1483 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Ethionamide mshA c.-303C>T mshA_c.-303C>T 1 upstream_gene_variant 575045 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA c.-309C>T mshA_c.-309C>T 1 upstream_gene_variant 575039 0 0 0 0 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1467 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA c.-315C>T mshA_c.-315C>T 1 upstream_gene_variant 575033 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1432 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide mshA c.318G>C mshA_c.318G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.-330C>T mshA_c.-330C>T 1 upstream_gene_variant 575018 1 4 0 4 0 4 5212 15483 0 0 0.000707516179821284 0.99974171886098 0.999338830952079 0.999929622742193 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 4.5014696306354 0.578098957200874 462.5 2233 False False 0 0 4.5014696306354 0 0 0.000707516179821284 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA c.-338G>A mshA_c.-338G>A 1 upstream_gene_variant 575010 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA c.339G>A mshA_c.339G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.-34C>T mshA_c.-34C>T 1 upstream_gene_variant 575314 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1449 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA c.-354G>A mshA_c.-354G>A 1 upstream_gene_variant 574994 1 4 0 4 0 4 5212 15483 0 0 0.000707516179821284 0.99974171886098 0.999338830952079 0.999929622742193 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 4.5014696306354 0.578098957200874 462.5 2233 False False 0 0 4.5014696306354 0 0 0.000707516179821284 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA c.-354G>C mshA_c.-354G>C 1 upstream_gene_variant 574994 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1450 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA c.372C>T mshA_c.372C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.375G>T mshA_c.375G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.-376C>T mshA_c.-376C>T 1 upstream_gene_variant 574972 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA c.-378A>C mshA_c.-378A>C 1 upstream_gene_variant 574970 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA c.396C>T mshA_c.396C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.-39C>A mshA_c.-39C>A 1 upstream_gene_variant 575309 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1464 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA c.-407C>T mshA_c.-407C>T 1 upstream_gene_variant 574941 1 2 0 2 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 15.8222760528043 1 815 2233 False False 0 0 7.19247409791798 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA c.414C>T mshA_c.414C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 13 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.-419A>G mshA_c.-419A>G 1 upstream_gene_variant 574929 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA c.-421C>T mshA_c.-421C>T 1 upstream_gene_variant 574927 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1477 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA c.-424C>T mshA_c.-424C>T 1 upstream_gene_variant 574924 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1405 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA c.-426T>C mshA_c.-426T>C 1 upstream_gene_variant 574922 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1411 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 704 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA c.-426T>G mshA_c.-426T>G 1 upstream_gene_variant 574922 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide mshA c.-427C>T mshA_c.-427C>T 1 upstream_gene_variant 574921 1 1 0 1 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 115.669966941234 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 1 3) Uncertain significance No change no 1 +Ethionamide mshA c.-434G>A mshA_c.-434G>A 1 upstream_gene_variant 574914 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1473 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA c.435G>T mshA_c.435G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 5212 15483 0 0 0.000707516179821284 0.99974171886098 0.999338830952079 0.999929622742193 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.5014696306354 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.2999762698034 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.-435T>G mshA_c.-435T>G 1 upstream_gene_variant 574913 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1468 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA c.-438C>A mshA_c.-438C>A 1 upstream_gene_variant 574910 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1488 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA c.-439C>T mshA_c.-439C>T 1 upstream_gene_variant 574909 1 4 1 3 1 4 5211 15483 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99974171886098 0.999338830952079 0.999929622742193 0.2 0.00505076337946806 0.716417936118089 0.25 0.00630946320970987 0.805879550316756 0.2 0.00505076337946806 0.716417936118089 0.990404912684705 0.018862152417974 12.3365577722115 1 815 2233 False False 0.742803684513529 0.0150842538989179 7.50989306640636 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide mshA c.-442G>A mshA_c.-442G>A 1 upstream_gene_variant 574906 1 9 1 8 1 8 5211 15479 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99948343772196 0.998982421476308 0.999776959534822 0.111111111111111 0.00280913674659921 0.482496514917337 0.111111111111111 0.00280913674659921 0.482496514917337 0.111111111111111 0.00280913674659921 0.482496514917337 0.371305891383611 0.00836999418610458 2.77069344974123 0.465037164812223 421.5 2233 False False 0.371305891383611 0.00836999418610458 2.77069344974123 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99948343772196 0.998982421476308 0.999776959534822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 1 6 1 6 2169 3784 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.998416886543535 0.996557436795264 0.999418810659556 0.142857142857142 0.00361029686190058 0.578723197043195 0.142857142857142 0.00361029686190058 0.578723197043195 0.142857142857142 0.00361029686190058 0.578723197043195 0.29076379283848097 0.00632256517654589 2.39937940259791 0.434011985866556 219.5 1065 False False 0 0 0 0 0 0 0 0.29076379283848097 0.00632256517654589 2.39937940259791 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.998416886543535 0.996557436795264 0.999418810659556 5 3) Uncertain significance No change no 1 +Ethionamide mshA c.444C>T mshA_c.444C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.-448G>C mshA_c.-448G>C 1 upstream_gene_variant 574900 1 1 0 1 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 115.669966941234 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 735 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 22 3) Uncertain significance No change no 1 +Ethionamide mshA c.450C>T mshA_c.450C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.453G>A mshA_c.453G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.-453T>G mshA_c.-453T>G 1 upstream_gene_variant 574895 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethionamide mshA c.45G>A mshA_c.45G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.-460G>A mshA_c.-460G>A 1 upstream_gene_variant 574888 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1489 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide mshA c.471G>A mshA_c.471G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 1 5210 15486 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 5.9447216890595 0.309382652589367 349.949104522224 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.-480C>T mshA_c.-480C>T 1 upstream_gene_variant 574868 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA c.486C>T mshA_c.486C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.19247409791798 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 2170 3787 0 0 0.00169850036174098 0.999208443271767 0.997688494809834 0.999836732216022 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.22663965322398 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.-486T>C mshA_c.-486T>C 1 upstream_gene_variant 574862 1 55 4 51 8 65 5204 15422 0.00153491941673062 0.000662894835129567 0.00302215107874993 0.995802931490928 0.994653576077271 0.996759342355386 0.10958904109589 0.04851642372111 0.204564320848606 0.0727272727272727 0.02017053335323 0.175867535283968 0.0579710144927536 0.0160191585330932 0.141828907792285 0.232430558695422 0.0609557810929247 0.632896068171754 0.000965659855450672 41 2233 False False 0.364737184414355 0.151034397896868 0.76281351931959 0.000768049155145929 0.000209305933468672 0.00196533275694761 0.995802931490928 0.994653576077271 0.996759342355386 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 5 3) Uncertain significance No change no 1 +Ethionamide mshA c.-486T>G mshA_c.-486T>G 1 upstream_gene_variant 574862 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1445 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA c.48C>T mshA_c.48C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.490C>T mshA_c.490C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 10 59 5202 15428 0.00191864927091327 0.000920438305261622 0.00352562450313611 0.996190353199457 0.995088548577374 0.997098693511357 0.144927536231884 0.0717491398920637 0.250419946716296 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.502674981591174 0.229076113957017 0.991768443323247 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.2999762698034 NA NA NA NA NA NA 12 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.-491G>A mshA_c.-491G>A 1 upstream_gene_variant 574857 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide mshA c.504C>T mshA_c.504C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.19247409791798 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.-506G>A mshA_c.-506G>A 1 upstream_gene_variant 574842 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA c.-515A>G mshA_c.-515A>G 1 upstream_gene_variant 574833 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA c.-518T>C mshA_c.-518T>C 1 upstream_gene_variant 574830 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1469 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA c.-518T>G mshA_c.-518T>G 1 upstream_gene_variant 574830 1 1 0 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 115.699581334225 1 815 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 720 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide mshA c.-524C>T mshA_c.-524C>T 1 upstream_gene_variant 574824 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1474 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Ethionamide mshA c.-527C>T mshA_c.-527C>T 1 upstream_gene_variant 574821 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1457 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 725 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA c.-528G>T mshA_c.-528G>T 1 upstream_gene_variant 574820 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA c.-535G>T mshA_c.-535G>T 1 upstream_gene_variant 574813 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1433 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA c.-539G>C mshA_c.-539G>C 1 upstream_gene_variant 574809 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA c.-553A>G mshA_c.-553A>G 1 upstream_gene_variant 574795 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 12 3) Uncertain significance No change no 1 +Ethionamide mshA c.-561G>A mshA_c.-561G>A 1 upstream_gene_variant 574787 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Ethionamide mshA c.-565C>G mshA_c.-565C>G 1 upstream_gene_variant 574783 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 2 3) Uncertain significance No change no 1 +Ethionamide mshA c.-566C>T mshA_c.-566C>T 1 upstream_gene_variant 574782 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1422 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 710 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 6 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA c.567C>A mshA_c.567C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.-570C>T mshA_c.-570C>T 1 upstream_gene_variant 574778 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethionamide mshA c.573C>T mshA_c.573C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 15 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.-574C>A mshA_c.-574C>A 1 upstream_gene_variant 574774 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1460 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide mshA c.-574C>G mshA_c.-574C>G 1 upstream_gene_variant 574774 1 5 0 5 0 6 5212 15481 0 0 0.000707516179821284 0.99961257829147 0.999156938222445 0.999857810215121 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 3.2426835385054 0.339824258678335 348.5 2233 False False 0 0 2.52357746319564 0 0 0.000707516179821284 0.99961257829147 0.999156938222445 0.999857810215121 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 5 2170 3785 0 0 0.00169850036174098 0.998680738786279 0.996923992057454 0.999571505100005 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 2.64472805420513 0.303691606806886 92 1065 False False 0 0 0 0 0 0 0 0 0 1.90544972133019 0 0 0.00169850036174098 0.998680738786279 0.996923992057454 0.999571505100005 2 3) Uncertain significance No change no 1 +Ethionamide mshA c.-574C>T mshA_c.-574C>T 1 upstream_gene_variant 574774 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1439 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA c.-576C>T mshA_c.-576C>T 1 upstream_gene_variant 574772 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1490 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 734 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA c.-579C>T mshA_c.-579C>T 1 upstream_gene_variant 574769 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1510 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA c.582C>T mshA_c.582C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.-589C>G mshA_c.-589C>G 1 upstream_gene_variant 574759 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA c.-590G>A mshA_c.-590G>A 1 upstream_gene_variant 574758 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1419 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA c.-591G>C mshA_c.-591G>C 1 upstream_gene_variant 574757 0 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1409 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA c.603C>A mshA_c.603C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.-622C>T mshA_c.-622C>T 1 upstream_gene_variant 574726 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethionamide mshA c.-629G>T mshA_c.-629G>T 1 upstream_gene_variant 574719 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA c.-630A>C mshA_c.-630A>C 1 upstream_gene_variant 574718 1 2 0 2 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 15.8222760528043 1 815 2233 False False 0 0 7.19247409791798 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 68.0259170395529 1 405 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 1 3) Uncertain significance No change no 1 +Ethionamide mshA c.630G>T mshA_c.630G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.-632G>A mshA_c.-632G>A 1 upstream_gene_variant 574716 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 14 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA c.-63G>T mshA_c.-63G>T 1 upstream_gene_variant 575285 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA c.-641C>T mshA_c.-641C>T 1 upstream_gene_variant 574707 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA c.-64C>A mshA_c.-64C>A 1 upstream_gene_variant 575284 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA c.-650G>A mshA_c.-650G>A 1 upstream_gene_variant 574698 0 0 0 0 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1486 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA c.-651C>T mshA_c.-651C>T 1 upstream_gene_variant 574697 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide mshA c.-65C>G mshA_c.-65C>G 1 upstream_gene_variant 575283 1 51 0 51 2 56 5210 15431 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.996384064053722 0.995306942512159 0.997267439701065 0.0344827586206896 0.00420364723986767 0.119077310880392 0 0 0.0697770307495386 0 0 0.0637500966623622 0 0 0.222284114748428 7.13358892307753e-07 20 2233 True False 0.105778722237455 0.0125004150111294 0.400636308061883 0 0 0.000707787682982558 0.996384064053722 0.995306942512159 0.997267439701065 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.2999762698034 0.53686319604546 244.5 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 60 3) Uncertain significance No change no 1 +Ethionamide mshA c.-65C>T mshA_c.-65C>T 1 upstream_gene_variant 575283 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA c.-660G>A mshA_c.-660G>A 1 upstream_gene_variant 574688 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1416 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide mshA c.-660G>C mshA_c.-660G>C 1 upstream_gene_variant 574688 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide mshA c.-667C>T mshA_c.-667C>T 1 upstream_gene_variant 574681 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1427 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Ethionamide mshA c.-669C>G mshA_c.-669C>G 1 upstream_gene_variant 574679 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA c.-669C>T mshA_c.-669C>T 1 upstream_gene_variant 574679 1 1 0 1 3 1 5209 15486 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.999935429715245 0.999640290494779 0.999998365223265 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 115.743923948461 1 496.5 2233 False False 8.91879439431752 0.715852821346612 466.959465949029 0 0 0.000707923512718415 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 729 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0 0 0.00170006591133688 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide mshA c.-66C>T mshA_c.-66C>T 1 upstream_gene_variant 575282 1 16 0 16 0 16 5212 15471 0 0 0.000707516179821284 0.99896687544392 0.998322811196946 0.999409368388177 0 0 0.205907214207822 0 0 0.205907214207822 0 0 0.205907214207822 0 0 0.770042176962822 0.0174584711694609 84 2233 False False 0 0 0.770042176962822 0 0 0.000707516179821284 0.99896687544392 0.998322811196946 0.999409368388177 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.2999762698034 0.53686319604546 244.5 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 18 3) Uncertain significance No change no 1 +Ethionamide mshA c.-67C>T mshA_c.-67C>T 1 upstream_gene_variant 575281 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA c.687T>C mshA_c.687T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.696G>A mshA_c.696G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.708C>T mshA_c.708C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.55810577429468 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.720C>T mshA_c.720C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.730C>T mshA_c.730C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 77 295 5135 15192 0.0147735993860322 0.0116762133195488 0.0184303092687432 0.980951765997288 0.978674031516474 0.983046204192386 0.206989247311827 0.166948366888542 0.251764705541369 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.772223854240588 0.59170977809797 0.99764701756903 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 34 64 2136 3726 0.0156682027649769 0.0108744540073486 0.0218264651060431 0.98311345646438 0.97848681727963 0.986971646318355 0.346938775510204 0.25359821285027 0.449803735549627 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.926702949438202 0.590572288100686 1.43152303302569 NA NA NA NA NA NA 462 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.-74G>A mshA_c.-74G>A 1 upstream_gene_variant 575274 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1511 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA c.781C>T mshA_c.781C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 4 3 5208 15484 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.999806289145735 0.999434000080036 0.999960050383188 0.571428571428571 0.184051567640083 0.901011721557492 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.96415770609319 0.670342430404991 27.0684059834314 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.795G>A mshA_c.795G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.-80_-76delCTGCA mshA_c.-80_-76delCTGCA 1 upstream_gene_variant 575267 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1512 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA c.813C>T mshA_c.813C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 9 5210 15478 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999418867437205 0.998897117312968 0.999734235852573 0.181818181818181 0.0228311982999596 0.517755852360172 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.660183407976114 0.0693911990938747 3.19086066213761 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 2 9 2168 3781 0.000921658986175115 0.000111636674590768 0.0033253435449308 0.997625329815303 0.995496943566885 0.998913592562977 0.181818181818181 0.0228311982999596 0.517755852360172 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.387556375563755 0.0407188446077131 1.87508262820954 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.819C>T mshA_c.819C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.829C>T mshA_c.829C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.837A>G mshA_c.837A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0761899451219867 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.-83C>T mshA_c.-83C>T 1 upstream_gene_variant 575265 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA c.840C>T mshA_c.840C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.843C>T mshA_c.843C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.852G>A mshA_c.852G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.87C>T mshA_c.87C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0761899451219867 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.894C>T mshA_c.894C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.903G>A mshA_c.903G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.912C>T mshA_c.912C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.-93G>T mshA_c.-93G>T 1 upstream_gene_variant 575255 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA c.948C>T mshA_c.948C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.97179044329303 0.0378514560716107 232.854636669753 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.955C>T mshA_c.955C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.963C>T mshA_c.963C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.19247409791798 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.969A>C mshA_c.969A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.969A>G mshA_c.969A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 5212 15482 0 0 0.000707516179821284 0.999677148576225 0.999246734667469 0.999895162977301 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.24289311550326 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.987G>A mshA_c.987G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.990G>A mshA_c.990G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA c.9T>C mshA_c.9T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide mshA deletion mshA_deletion 1 feature_ablation (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1442 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA LoF mshA_LoF 1 LoF (see "Genomic_coordinates" sheet) 1 16 7 9 28 23 5184 15464 0.00537221795855717 0.00357268007260088 0.00775505962083478 0.998514883450636 0.997772424247496 0.999058337853371 0.549019607843137 0.403418822904792 0.68872497260887 0.4375 0.197534140532667 0.701223100916822 0.233333333333333 0.0993378649580198 0.422836522978219 2.32013031550068 0.733855735460702 7.00474914776078 0.143389804615245 158 2233 False False 3.63150831991411 2.01501959438645 6.60622534447007 0.00134848776728953 0.000542328471575816 0.00277641408788761 0.998514883450636 0.997772424247496 0.999058337853371 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 1 3 9 7 2161 3783 0.00414746543778801 0.00189818564765315 0.00785851894409672 0.998153034300791 0.996198270365656 0.999257111678459 0.5625 0.298776899083177 0.802465859467332 0.25 0.00630946320970987 0.805879550316756 0.125 0.0031597235312519 0.526509670875206 0.5835261453031 0.0111149530905178 7.27322221219395 1 405 1065 False False 0 0 0 0 0 0 0 2.25074370331195 0.744561915163929 7.12219168139304 0.000462534690101757 1.17102959040189e-05 0.00257435532747442 0.998153034300791 0.996198270365656 0.999257111678459 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Ala104fs mshA_p.Ala104fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1478 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA p.Ala134Val mshA_p.Ala134Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1412 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 705 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0 0 0.00170006591133688 1 0.999027154404229 1 5 3) Uncertain significance No change no 1 +Ethionamide mshA p.Ala177Thr mshA_p.Ala177Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1513 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA p.Ala182Thr mshA_p.Ala182Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 1 7 2 7 5210 15480 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999548008006715 0.999068946905294 0.99981825708278 0.222222222222222 0.0281449734778982 0.600093573716312 0.125 0.0031597235312519 0.526509670875206 0.125 0.0031597235312519 0.526509670875206 0.424458459007403 0.0094198787616194 3.30527028238434 0.688498280252011 479 2233 False False 0.848916918014806 0.0860206666092397 4.46043370684753 0.000191901746305891 4.8585197621771e-06 0.00106873920290263 0.999548008006715 0.999068946905294 0.99981825708278 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 68.0751891811639 1 405 1065 False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 0 0 0.0016992827759538 0.999736147757256 0.998530795728906 0.999993319861894 40 3) Uncertain significance No change no 1 +Ethionamide mshA p.Ala187Thr mshA_p.Ala187Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 11 0 11 0 11 5212 15476 0 0 0.000707516179821284 0.999289726867695 0.998729481387772 0.999645382583254 0 0 0.284914152918154 0 0 0.284914152918154 0 0 0.284914152918154 0 0 1.18361858819336 0.0765549068676503 147 2233 False False 0 0 1.18361858819336 0 0 0.000707516179821284 0.999289726867695 0.998729481387772 0.999645382583254 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide mshA p.Ala187Val mshA_p.Ala187Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 3109 108 3001 2187 4517 3025 10970 0.419608595548733 0.406163187763592 0.43314410892277 0.708336023761864 0.701106519844288 0.715487199723325 0.326223150357995 0.315003465987536 0.337594169705182 0.0347378578321003 0.0285814227489112 0.0417884362150363 0.0233513513513513 0.0191939639254834 0.0281244879420964 0.130508563261282 0.106260693304057 0.158918099098637 1.07835845406813e-162 2 2233 True True 1.75581979555654 1.64424932009594 1.87463555237879 0.0344717523140759 0.0283618224315358 0.0414694828465271 0.708336023761864 0.701106519844288 0.715487199723325 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 811 54 757 987 1563 1183 2227 0.454838709677419 0.433730075117223 0.476069481492614 0.587598944591029 0.571732262736674 0.603330396657137 0.387058823529411 0.368096586160121 0.40628080469685 0.0665844636251541 0.0504125969016425 0.0859882926669257 0.0333951762523191 0.0251850351762856 0.0433506652076514 0.134286808608523 0.0990717357044272 0.178949672005029 2.33448770634937e-68 2 1065 True True 0 0 0 1 0 0 0 1.18875853218094 1.06714557579375 1.32410334104218 0.0436540016168148 0.0329615107155175 0.0565777362345946 0.587598944591029 0.571732262736674 0.603330396657137 7497 5) Not assoc w R UP from Uncertain to NotAwR yes 4 +Ethionamide mshA p.Ala189fs mshA_p.Ala189fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 4 5211 15483 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99974171886098 0.999338830952079 0.999929622742193 0.2 0.00505076337946806 0.716417936118089 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1496 2233 False False 0.742803684513529 0.0150842538989179 7.50989306640636 0 0 0.000707651905360176 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethionamide mshA p.Ala189Val mshA_p.Ala189Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.2999762698034 0.53686319604546 244.5 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 1 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Ala233Glu mshA_p.Ala233Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA p.Ala24Val mshA_p.Ala24Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 115.669966941234 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethionamide mshA p.Ala279fs mshA_p.Ala279fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide mshA p.Ala2Thr mshA_p.Ala2Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 115.699581334225 1 815 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide mshA p.Ala323Thr mshA_p.Ala323Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1484 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Ala337Thr mshA_p.Ala337Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA p.Ala342Val mshA_p.Ala342Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA p.Ala343Val mshA_p.Ala343Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.2999762698034 0.53686319604546 244.5 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 1 3) Uncertain significance No change no 1 +Ethionamide mshA p.Ala347Val mshA_p.Ala347Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA p.Ala364Val mshA_p.Ala364Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1465 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA p.Ala372fs mshA_p.Ala372fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Ala399Thr mshA_p.Ala399Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1507 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 743 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Ala41Glu mshA_p.Ala41Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1451 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Ala421Glu mshA_p.Ala421Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1440 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 718 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Ala422fs mshA_p.Ala422fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1491 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Ala480Val mshA_p.Ala480Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1443 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 719 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 1 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Ala48Val mshA_p.Ala48Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 5212 15482 0 0 0.000707516179821284 0.999677148576225 0.999246734667469 0.999895162977301 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 3.24289311550326 0.33983036876334 352 2233 False False 0 0 3.24289311550326 0 0 0.000707516179821284 0.999677148576225 0.999246734667469 0.999895162977301 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethionamide mshA p.Ala65Val mshA_p.Ala65Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1441 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Ala76Ser mshA_p.Ala76Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA p.Arg168Cys mshA_p.Arg168Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA p.Arg222fs mshA_p.Arg222fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 5 1 5207 15486 0.000959324635456638 0.000311561141138009 0.0022373118395626 0.999935429715245 0.999640290494779 0.999998365223265 0.833333333333333 0.358765421002325 0.99578925548551 NA NA NA 0 0 0.975 NA NA NA NA 1461 2233 False False 14.8703668139043 1.66317699294464 700.725693531947 0 0 0.00070819532865061 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Arg253Leu mshA_p.Arg253Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Arg26Cys mshA_p.Arg26Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 5212 15483 0 0 0.000707516179821284 0.99974171886098 0.999338830952079 0.999929622742193 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 4.5014696306354 0.578098957200874 462.5 2233 False False 0 0 4.5014696306354 0 0 0.000707516179821284 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 14 3) Uncertain significance No change no 1 +Ethionamide mshA p.Arg26His mshA_p.Arg26His 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA p.Arg273Gly mshA_p.Arg273Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1508 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 744 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide mshA p.Arg294Cys mshA_p.Arg294Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA p.Arg324Gln mshA_p.Arg324Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 15.8222760528043 1 815 2233 False False 0 0 7.19247409791798 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide mshA p.Arg324Trp mshA_p.Arg324Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Arg413Gln mshA_p.Arg413Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 5212 15481 0 0 0.000707516179821284 0.99961257829147 0.999156938222445 0.999857810215121 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 2.52357746319564 0.347651033317578 363.5 2233 False False 0 0 2.52357746319564 0 0 0.000707516179821284 0.99961257829147 0.999156938222445 0.999857810215121 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.2999762698034 0.53686319604546 244.5 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 5 3) Uncertain significance No change no 1 +Ethionamide mshA p.Arg413Trp mshA_p.Arg413Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.2999762698034 0.53686319604546 244.5 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 1 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Arg443His mshA_p.Arg443His 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 3 6 5209 15481 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.99961257829147 0.999156938222445 0.999857810215121 0.333333333333333 0.0748546314196918 0.700704943791459 0 0 0.707598226178713 0 0 0.4592581264399 0 0 7.19522329579624 0.577130384951403 452 2233 False False 1.48598579381839 0.240373448133868 6.9606999827616 0 0 0.000707923512718415 0.99961257829147 0.999156938222445 0.999857810215121 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 2 2167 3788 0.00138248847926267 0.000285193152965682 0.0040348522148252 0.999472295514512 0.998095063429584 0.999936086148442 0.6 0.146632799634673 0.947255049473683 0 0 0.975 0 0 0.841886116991581 0 0 68.1199920445773 1 405 1065 False False 0 0 0 0 0 0 0 2.62205814490078 0.300049946119759 31.4084209142753 0 0 0.00170084976888778 0.999472295514512 0.998095063429584 0.999936086148442 39 3) Uncertain significance No change no 1 +Ethionamide mshA p.Arg455Leu mshA_p.Arg455Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA p.Arg45Leu mshA_p.Arg45Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA p.Arg46Trp mshA_p.Arg46Trp 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 722 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Arg81fs mshA_p.Arg81fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA p.Arg81Gly mshA_p.Arg81Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Asn111Ser mshA_p.Asn111Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 985 24 961 276 1137 4936 14350 0.0529547198772064 0.0470308503001394 0.059385254705517 0.926583586233615 0.922362881094253 0.930643205247734 0.195329087048832 0.174954124982701 0.216978964296794 0.0243654822335025 0.0156723775323444 0.0360380130792192 0.020671834625323 0.0132886480555119 0.0306026964057732 0.0726046780686649 0.0462421016099376 0.108852489737989 4.03830844367913e-87 6 2233 True True 0.705708530937423 0.614053768555704 0.808946980339372 0.00483870967741935 0.00310263912860184 0.0071911146188669 0.926583586233615 0.922362881094253 0.930643205247734 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 136 5 131 62 173 2108 3617 0.0285714285714285 0.0219741643482138 0.0364791223913734 0.954353562005277 0.94721772534615 0.960777646740547 0.263829787234042 0.208659175207318 0.325064904031979 0.0367647058823529 0.0120433191632555 0.0837099503746627 0.0280898876404494 0.00918231556792643 0.0643320499846411 0.065490244361719 0.0208858776305312 0.157182254355238 5.03067542740476e-20 5 1065 True True 0 0 0 1 0 0 0 0.614926895613736 0.450195380322182 0.830957506541215 0.00236630383341221 0.000768764913857166 0.0055134547213765 0.954353562005277 0.94721772534615 0.960777646740547 2572 5) Not assoc w R UP from Uncertain to NotAwR yes 4 +Ethionamide mshA p.Asn37Asp mshA_p.Asn37Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 7.19247409791798 0.577090863007554 439 2233 False False 0 0 7.19247409791798 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA p.Asn69Ser mshA_p.Asn69Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 5 3 5207 15484 0.000959324635456638 0.000311561141138009 0.0022373118395626 0.999806289145735 0.999434000080036 0.999960050383188 0.625 0.244863216366551 0.914766585862746 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1428 2233 False False 4.95614877408616 0.963790796814113 31.9243794332185 0 0 0.00070819532865061 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 5 3 2165 3787 0.00230414746543778 0.000748560476988087 0.00536885389822181 0.999208443271767 0.997688494809834 0.999836732216022 0.625 0.244863216366551 0.914766585862746 NA NA NA 0 0 0.707598226178713 NA NA NA NA 713 1065 False False 0 0 0 0 0 0 0 2.9153194765204 0.566479632607818 18.786985063018 0 0 0.00170241965449235 0.999208443271767 0.997688494809834 0.999836732216022 1 3) Uncertain significance No change no 1 +Ethionamide mshA p.Asp121fs mshA_p.Asp121fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1470 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 730 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0 0 0.00170006591133688 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Asp121Gly mshA_p.Asp121Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide mshA p.Asp124Asn mshA_p.Asp124Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1446 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide mshA p.Asp167Ala mshA_p.Asp167Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Asp190Asn mshA_p.Asp190Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 4 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Asp190fs mshA_p.Asp190fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1413 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide mshA p.Asp192fs mshA_p.Asp192fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1420 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide mshA p.Asp218Ala mshA_p.Asp218Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 91 1 90 10 107 5202 15380 0.00191864927091327 0.000920438305261622 0.00352562450313611 0.993090979531219 0.991657173627714 0.994334536439452 0.0854700854700854 0.0417491088821878 0.15156825050101 0.0109890109890109 0.000278178971210031 0.0597108128163317 0.00925925925925925 0.000234396672809092 0.0505105336567462 0.0328506130120893 0.000826931069607165 0.187844447271839 1.87310063341292e-10 13 2233 True False 0.276313567391405 0.128727580228956 0.528723593745616 0.000192196809532961 4.86599007998053e-06 0.00107038174713725 0.993090979531219 0.991657173627714 0.994334536439452 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 3 12 2167 3778 0.00138248847926267 0.000285193152965682 0.0040348522148252 0.996833773087071 0.994475777251357 0.998362927167916 0.2 0.0433120051058366 0.480891133806853 0 0 0.30849710781876 0 0 0.264648469397051 0 0 0.778776407668784 0.0171121556821703 28 1065 False False 0 0 0 0 0 0 0 0.435856022150438 0.0788513303216526 1.61768915135241 0 0 0.00170084976888778 0.996833773087071 0.994475777251357 0.998362927167916 183 3) Uncertain significance No change no 1 +Ethionamide mshA p.Asp218Glu mshA_p.Asp218Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1492 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide mshA p.Asp218Gly mshA_p.Asp218Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1485 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 733 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Asp231fs mshA_p.Asp231fs 1 frameshift (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Asp236Gly mshA_p.Asp236Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1444 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Asp281Gly mshA_p.Asp281Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide mshA p.Asp400fs mshA_p.Asp400fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1479 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Asp403Gly mshA_p.Asp403Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA p.Asp42Tyr mshA_p.Asp42Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethionamide mshA p.Asp64Asn mshA_p.Asp64Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethionamide mshA p.Gln128* mshA_p.Gln128* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Gln205Ser mshA_p.Gln205Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1423 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Gln205* mshA_p.Gln205* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide mshA p.Gln363* mshA_p.Gln363* 1 stop_gained (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1493 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 736 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Glu118Lys mshA_p.Glu118Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA p.Glu220Asp mshA_p.Glu220Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide mshA p.Glu220* mshA_p.Glu220* 1 stop_gained (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1458 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 726 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Glu353* mshA_p.Glu353* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Glu458Gln mshA_p.Glu458Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 0 8 5212 15479 0 0 0.000707516179821284 0.99948343772196 0.998982421476308 0.999776959534822 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 1.74050626415467 0.214442026858522 190.5 2233 False False 0 0 1.74050626415467 0 0 0.000707516179821284 0.99948343772196 0.998982421476308 0.999776959534822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 2170 3786 0 0 0.00169850036174098 0.998944591029023 0.997299958285064 0.999712364080324 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.6454264678615 0.303692649321994 95 1065 False False 0 0 0 0 0 0 0 0 0 2.6454264678615 0 0 0.00169850036174098 0.998944591029023 0.997299958285064 0.999712364080324 1 3) Uncertain significance No change no 1 +Ethionamide mshA p.Glu85Ala mshA_p.Glu85Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA p.Gly106Ala mshA_p.Gly106Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 6 5209 15481 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.99961257829147 0.999156938222445 0.999857810215121 0.333333333333333 0.0748546314196918 0.700704943791459 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1475 2233 False False 1.48598579381839 0.240373448133868 6.9606999827616 0 0 0.000707923512718415 0.99961257829147 0.999156938222445 0.999857810215121 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 731 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 18 3) Uncertain significance No change no 1 +Ethionamide mshA p.Gly106Arg mshA_p.Gly106Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Gly106Val mshA_p.Gly106Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 1 5210 15486 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 1406 2233 False False 5.9447216890595 0.309382652589367 349.949104522224 0 0 0.000707787682982558 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 1 2168 3789 0.000921658986175115 0.000111636674590768 0.0033253435449308 0.999736147757256 0.998530795728906 0.999993319861894 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 700 1065 False False 0 0 0 0 0 0 0 3.49538745387453 0.181825522231654 206.012215468794 0 0 0.00170006591133688 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Gly11Arg mshA_p.Gly11Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Gly21fs mshA_p.Gly21fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1452 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 723 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Gly260Arg mshA_p.Gly260Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethionamide mshA p.Gly292Arg mshA_p.Gly292Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 3 5209 15484 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.999806289145735 0.999434000080036 0.999960050383188 0.5 0.118117248757025 0.881882751242974 0 0 0.975 0 0 0.707598226178713 0 0 115.72900374078 1 815 2233 False False 2.97254751391821 0.397987980392264 22.1986618481397 0 0 0.000707923512718415 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 3 2169 3787 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999208443271767 0.997688494809834 0.999836732216022 0.25 0.00630946320970987 0.805879550316756 0 0 0.975 0 0 0.707598226178713 0 0 68.0393037893506 1 405 1065 False False 0 0 0 0 0 0 0 0.581988627631781 0.0110856993615618 7.25404417491437 0 0 0.0016992827759538 0.999208443271767 0.997688494809834 0.999836732216022 44 3) Uncertain significance No change no 1 +Ethionamide mshA p.Gly305Asp mshA_p.Gly305Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA p.Gly311* mshA_p.Gly311* 1 stop_gained (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1471 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Gly384Val mshA_p.Gly384Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA p.Gly396Ala mshA_p.Gly396Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Gly411Arg mshA_p.Gly411Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA p.Gly446Ser mshA_p.Gly446Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Ethionamide mshA p.Gly477Arg mshA_p.Gly477Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethionamide mshA p.Gly479Asp mshA_p.Gly479Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA p.Gly479Ser mshA_p.Gly479Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA p.Gly67Ala mshA_p.Gly67Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.55810577429468 Inf 0.0633939383341096 130.5 2233 False False Inf 0.55810577429468 Inf 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA p.Gly83Arg mshA_p.Gly83Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 5211 15485 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 115.692124084117 1 815 2233 False False 1.48579927077336 0.0251793916671698 28.5526337681963 0 0 0.000707651905360176 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 708 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide mshA p.His152Arg mshA_p.His152Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide mshA p.His154fs mshA_p.His154fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1417 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 707 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.His175fs mshA_p.His175fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 2 1 5210 15486 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 1466 2233 False False 5.9447216890595 0.309382652589367 349.949104522224 0 0 0.000707787682982558 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 728 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.His175Pro mshA_p.His175Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1476 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 732 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.His228Pro mshA_p.His228Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1500 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.His404Asn mshA_p.His404Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.His471Arg mshA_p.His471Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance No change no 1 +Ethionamide mshA p.His53fs mshA_p.His53fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1501 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.His53Pro mshA_p.His53Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1497 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 738 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Ile296Ser mshA_p.Ile296Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Ile402Thr mshA_p.Ile402Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA p.Ile84Leu mshA_p.Ile84Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1459 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA p.Leu12Trp mshA_p.Leu12Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1505 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 741 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Leu12Val mshA_p.Leu12Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA p.Leu137Pro mshA_p.Leu137Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 4 5210 15483 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.99974171886098 0.999338830952079 0.999929622742193 0.333333333333333 0.0432718682927417 0.777221904496487 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1487 2233 False False 1.48589251439539 0.134348817103157 10.3711983427491 0 0 0.000707787682982558 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Ethionamide mshA p.Leu157fs mshA_p.Leu157fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Leu188Val mshA_p.Leu188Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 1 8 5211 15479 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99948343772196 0.998982421476308 0.999776959534822 0.111111111111111 0.00280913674659921 0.482496514917337 0 0 0.409616397225003 0 0 0.369416647552819 0 0 2.06173339349289 0.203415794085323 185 2233 False False 0.371305891383611 0.00836999418610458 2.77069344974123 0 0 0.000707651905360176 0.99948343772196 0.998982421476308 0.999776959534822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 711 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 32 3) Uncertain significance No change no 1 +Ethionamide mshA p.Leu198Arg mshA_p.Leu198Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA p.Leu284Pro mshA_p.Leu284Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1506 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 742 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Leu290Phe mshA_p.Leu290Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Leu306Arg mshA_p.Leu306Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 5212 15482 0 0 0.000707516179821284 0.999677148576225 0.999246734667469 0.999895162977301 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 3.24289311550326 0.33983036876334 352 2233 False False 0 0 3.24289311550326 0 0 0.000707516179821284 0.999677148576225 0.999246734667469 0.999895162977301 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide mshA p.Leu377His mshA_p.Leu377His 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1429 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Leu389Pro mshA_p.Leu389Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 1 5210 15486 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 1502 2233 False False 5.9447216890595 0.309382652589367 349.949104522224 0 0 0.000707787682982558 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 1 2168 3789 0.000921658986175115 0.000111636674590768 0.0033253435449308 0.999736147757256 0.998530795728906 0.999993319861894 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 740 1065 False False 0 0 0 0 0 0 0 3.49538745387453 0.181825522231654 206.012215468794 0 0 0.00170006591133688 0.999736147757256 0.998530795728906 0.999993319861894 15 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Leu405Arg mshA_p.Leu405Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1462 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Leu408Ser mshA_p.Leu408Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA p.Leu73fs mshA_p.Leu73fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA p.Lys184Thr mshA_p.Lys184Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1437 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 717 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Lys278Glu mshA_p.Lys278Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide mshA p.Met417Val mshA_p.Met417Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1438 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA p.Met72Thr mshA_p.Met72Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Pro105Ser mshA_p.Pro105Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA p.Pro126fs mshA_p.Pro126fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA p.Pro197fs mshA_p.Pro197fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 4 5211 15483 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99974171886098 0.999338830952079 0.999929622742193 0.2 0.00505076337946806 0.716417936118089 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1480 2233 False False 0.742803684513529 0.0150842538989179 7.50989306640636 0 0 0.000707651905360176 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethionamide mshA p.Pro249Ala mshA_p.Pro249Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1414 2233 False False 0 0 7.19247409791798 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 2170 3787 0 0 0.00169850036174098 0.999208443271767 0.997688494809834 0.999836732216022 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 706 1065 False False 0 0 0 0 0 0 0 0 0 4.22663965322398 0 0 0.00169850036174098 0.999208443271767 0.997688494809834 0.999836732216022 1 3) Uncertain significance No change no 1 +Ethionamide mshA p.Pro249Leu mshA_p.Pro249Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Ethionamide mshA p.Pro249Ser mshA_p.Pro249Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1424 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA p.Pro280His mshA_p.Pro280His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1453 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Pro30Leu mshA_p.Pro30Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1430 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Pro33Ser mshA_p.Pro33Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA p.Pro469Leu mshA_p.Pro469Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1415 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA p.Pro474Leu mshA_p.Pro474Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Pro56Thr mshA_p.Pro56Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1503 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Ser10Leu mshA_p.Ser10Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 3 3) Uncertain significance No change no 1 +Ethionamide mshA p.Ser302fs mshA_p.Ser302fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Ser308Leu mshA_p.Ser308Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1494 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 737 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 2 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Ser31Phe mshA_p.Ser31Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA p.Ser352His mshA_p.Ser352His 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1514 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA p.Ser354Ala mshA_p.Ser354Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1515 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Ser429* mshA_p.Ser429* 1 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1425 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Ser461* mshA_p.Ser461* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA p.Ser95Pro mshA_p.Ser95Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Ter481ext*? mshA_p.Ter481ext*? 1 stop_lost (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1418 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Thr176fs mshA_p.Thr176fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA p.Thr179Arg mshA_p.Thr179Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1454 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethionamide mshA p.Thr334Ala mshA_p.Thr334Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 5212 15483 0 0 0.000707516179821284 0.99974171886098 0.999338830952079 0.999929622742193 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 7.19200955772979 0.577084182625794 428 2233 False False 0 0 4.5014696306354 0 0 0.000707516179821284 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 16 3) Uncertain significance No change no 1 +Ethionamide mshA p.Thr338Ala mshA_p.Thr338Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1481 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Thr386fs mshA_p.Thr386fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1407 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 701 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Thr388Ala mshA_p.Thr388Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA p.Thr93fs mshA_p.Thr93fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1426 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 712 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Trp169Cys mshA_p.Trp169Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA p.Tyr123* mshA_p.Tyr123* 1 stop_gained (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1434 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 714 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Tyr155Ser mshA_p.Tyr155Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1455 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 724 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Tyr351His mshA_p.Tyr351His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA p.Val224_Ser226del mshA_p.Val224_Ser226del 1 inframe_deletion (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1447 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Val238fs mshA_p.Val238fs 1 frameshift (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 7.19247409791798 0.577090863007554 439 2233 False False 0 0 7.19247409791798 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.2999762698034 0.53686319604546 244.5 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 2 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Val271Leu mshA_p.Val271Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1498 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Val293Trp mshA_p.Val293Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA p.Val325Met mshA_p.Val325Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 7.19247409791798 0.577090863007554 439 2233 False False 0 0 7.19247409791798 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.2999762698034 0.53686319604546 244.5 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 2 3) Uncertain significance No change no 1 +Ethionamide mshA p.Val346Ala mshA_p.Val346Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1456 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide mshA p.Val390Ala mshA_p.Val390Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 9 5212 15478 0 0 0.000707516179821284 0.999418867437205 0.998897117312968 0.999734235852573 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1421 2233 False False 0 0 1.50519575721189 0 0 0.000707516179821284 0.999418867437205 0.998897117312968 0.999734235852573 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 709 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 3 3) Uncertain significance No change no 1 +Ethionamide mshA p.Val416Met mshA_p.Val416Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide mshA p.Val478Ala mshA_p.Val478Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1435 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 715 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide mshA p.Val4Met mshA_p.Val4Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 5212 15483 0 0 0.000707516179821284 0.99974171886098 0.999338830952079 0.999929622742193 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 4.5014696306354 0.578098957200874 462.5 2233 False False 0 0 4.5014696306354 0 0 0.000707516179821284 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.2999762698034 0.53686319604546 244.5 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 9 3) Uncertain significance No change no 1 +Ethionamide mshA p.Val86fs mshA_p.Val86fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1499 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 739 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh c.1017G>A ndh_c.1017G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.1032C>G ndh_c.1032C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 12 5211 15475 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99922515658294 0.998646896080726 0.999599565042795 0.0769230769230769 0.00194562849734675 0.360297435267877 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.247473293673639 0.00579175760647496 1.67334013776859 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.1044G>A ndh_c.1044G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.1080G>A ndh_c.1080G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.55810577429468 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.108C>T ndh_c.108C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.1122G>A ndh_c.1122G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 14 5212 15473 0 0 0.000707516179821284 0.99909601601343 0.998483733164878 0.999505698211522 0 0 0.231635761650116 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.895402656698445 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 11 2170 3779 0 0 0.00169850036174098 0.997097625329815 0.994812797611582 0.998550282198211 0 0 0.284914152918154 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.694759935614295 NA NA NA NA NA NA 64 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.1128T>C ndh_c.1128T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.1140C>G ndh_c.1140C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.1152C>G ndh_c.1152C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 5212 15482 0 0 0.000707516179821284 0.999677148576225 0.999246734667469 0.999895162977301 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.24289311550326 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.1164C>T ndh_c.1164C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.1194G>A ndh_c.1194G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.1195C>T ndh_c.1195C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 13 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.1203G>A ndh_c.1203G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.97179044329303 0.0378514560716107 232.854636669753 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.120C>A ndh_c.120C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.1210C>T ndh_c.1210C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.1212G>A ndh_c.1212G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 9 60 5203 15427 0.00172678434382194 0.000789890217063144 0.00327543249467561 0.996125782914702 0.995015890582708 0.997042301362845 0.130434782608695 0.0614170997401163 0.233218959794861 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.44475302709975 0.193884615393861 0.902694206384157 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.2999762698034 NA NA NA NA NA NA 12 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.124C>T ndh_c.124C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.2999762698034 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.1266C>G ndh_c.1266C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.1314G>A ndh_c.1314G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.1320G>C ndh_c.1320G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 5212 15482 0 0 0.000707516179821284 0.999677148576225 0.999246734667469 0.999895162977301 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.24289311550326 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.1332G>A ndh_c.1332G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.1338C>G ndh_c.1338C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.1342C>T ndh_c.1342C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.1344G>T ndh_c.1344G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0761899451219867 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.135C>T ndh_c.135C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.138C>T ndh_c.138C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.1392G>A ndh_c.1392G>A 2 stop_retained_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.2999762698034 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.147C>T ndh_c.147C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0761899451219867 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.148C>T ndh_c.148C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0761899451219867 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.156G>A ndh_c.156G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.159G>A ndh_c.159G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 5212 15483 0 0 0.000707516179821284 0.99974171886098 0.999338830952079 0.999929622742193 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.5014696306354 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.168C>T ndh_c.168C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.180C>T ndh_c.180C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.183G>C ndh_c.183G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.186T>C ndh_c.186T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.-18C>T ndh_c.-18C>T 2 upstream_gene_variant 2103060 NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2196 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh c.-1C>G ndh_c.-1C>G 2 upstream_gene_variant 2103043 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2145 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ndh c.-1C>T ndh_c.-1C>T 2 upstream_gene_variant 2103043 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2068 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 994 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh c.204C>A ndh_c.204C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.21C>G ndh_c.21C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 24 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.228G>A ndh_c.228G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.-22A>G ndh_c.-22A>G 2 upstream_gene_variant 2103064 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2178 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ndh c.-23_-22insG ndh_c.-23_-22insG 2 upstream_gene_variant 2103064 NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2179 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1041 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh c.-23G>A ndh_c.-23G>A 2 upstream_gene_variant 2103065 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2066 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ndh c.252A>C ndh_c.252A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 11 5212 15476 0 0 0.000707516179821284 0.999289726867695 0.998729481387772 0.999645382583254 0 0 0.284914152918154 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.18361858819336 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.253C>T ndh_c.253C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.19247409791798 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.255G>A ndh_c.255G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.267C>T ndh_c.267C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.-26G>C ndh_c.-26G>C 2 upstream_gene_variant 2103068 NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2120 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1016 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh c.270C>G ndh_c.270C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.27G>A ndh_c.27G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 3 5211 15484 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999806289145735 0.999434000080036 0.999960050383188 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.990468879933474 0.0188633706776044 12.3373543450537 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 3 2169 3787 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999208443271767 0.997688494809834 0.999836732216022 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.581988627631781 0.0110856993615618 7.25404417491437 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.288G>T ndh_c.288G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.-28G>A ndh_c.-28G>A 2 upstream_gene_variant 2103070 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 2 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh c.312C>T ndh_c.312C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.315T>G ndh_c.315T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.321C>G ndh_c.321C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0761899451219867 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.324C>T ndh_c.324C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.33A>C ndh_c.33A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.2999762698034 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.33A>G ndh_c.33A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.-34C>T ndh_c.-34C>T 2 upstream_gene_variant 2103076 1 0 0 0 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2184 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1044 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 2 3) Uncertain significance No change no 1 +Ethionamide ndh c.372T>C ndh_c.372T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.387C>T ndh_c.387C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.97179044329303 0.0378514560716107 232.854636669753 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.408C>A ndh_c.408C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0761899451219867 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.-40A>G ndh_c.-40A>G 2 upstream_gene_variant 2103082 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2191 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1046 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh c.411C>T ndh_c.411C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.429C>T ndh_c.429C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.97179044329303 0.0378514560716107 232.854636669753 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.-45A>G ndh_c.-45A>G 2 upstream_gene_variant 2103087 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2181 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ndh c.46C>A ndh_c.46C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.-46T>G ndh_c.-46T>G 2 upstream_gene_variant 2103088 0 0 0 0 3 13 5209 15474 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.999160586298185 0.998565004766387 0.999552974256682 0.1875 0.0404737339059459 0.456456546231611 NA NA NA 0 0 0.24705263800047 NA NA NA NA 2139 2233 False False 0.685529482995407 0.125257070543251 2.49616387137143 0 0 0.000707923512718415 0.999160586298185 0.998565004766387 0.999552974256682 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 13 2167 3777 0.00138248847926267 0.000285193152965682 0.0040348522148252 0.996569920844327 0.994141602714116 0.99817240212944 0.1875 0.0404737339059459 0.456456546231611 NA NA NA 0 0 0.24705263800047 NA NA NA NA 1025 1065 False False 0 0 0 0 0 0 0 0.402222143338894 0.0734460704652355 1.46607154716367 0 0 0.00170084976888778 0.996569920844327 0.994141602714116 0.99817240212944 48 3) Uncertain significance No change no 1 +Ethionamide ndh c.498G>A ndh_c.498G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.19247409791798 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.-51G>C ndh_c.-51G>C 2 upstream_gene_variant 2103093 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ndh c.528C>A ndh_c.528C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.-54G>T ndh_c.-54G>T 2 upstream_gene_variant 2103096 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ndh c.570C>T ndh_c.570C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.-57A>G ndh_c.-57A>G 2 upstream_gene_variant 2103099 NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2106 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh c.606G>C ndh_c.606G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.615C>T ndh_c.615C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.633G>A ndh_c.633G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.639G>A ndh_c.639G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.-65G>A ndh_c.-65G>A 2 upstream_gene_variant 2103107 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2218 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ndh c.663G>A ndh_c.663G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.97179044329303 0.0378514560716107 232.854636669753 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.675C>T ndh_c.675C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.706T>C ndh_c.706T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.-70G>T ndh_c.-70G>T 2 upstream_gene_variant 2103112 1 3 0 3 0 14 5212 15473 0 0 0.000707516179821284 0.99909601601343 0.998483733164878 0.999505698211522 0 0 0.231635761650116 0 0 0.707598226178713 0 0 0.231635761650116 0 0 7.18736415365639 0.577017404133682 427 2233 False False 0 0 0.895402656698445 0 0 0.000707516179821284 0.99909601601343 0.998483733164878 0.999505698211522 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 11 2170 3779 0 0 0.00169850036174098 0.997097625329815 0.994812797611582 0.998550282198211 0 0 0.284914152918154 0 0 0.975 0 0 0.284914152918154 0 0 67.8645066273932 1 405 1065 False False 0 0 0 0 0 0 0 0 0 0.694759935614295 0 0 0.00169850036174098 0.997097625329815 0.994812797611582 0.998550282198211 63 3) Uncertain significance No change no 1 +Ethionamide ndh c.753C>T ndh_c.753C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.-75G>A ndh_c.-75G>A 2 upstream_gene_variant 2103117 NA 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2078 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1000 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 1 3) Uncertain significance No change no 1 +Ethionamide ndh c.-75G>C ndh_c.-75G>C 2 upstream_gene_variant 2103117 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2172 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1038 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh c.768C>T ndh_c.768C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.786C>T ndh_c.786C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.810G>A ndh_c.810G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.822G>A ndh_c.822G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.19247409791798 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.834C>T ndh_c.834C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.858C>T ndh_c.858C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.864C>T ndh_c.864C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.894C>T ndh_c.894C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.897G>A ndh_c.897G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.903C>T ndh_c.903C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 5212 15482 0 0 0.000707516179821284 0.999677148576225 0.999246734667469 0.999895162977301 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.24289311550326 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.906G>A ndh_c.906G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.-90T>C ndh_c.-90T>C 2 upstream_gene_variant 2103132 1 0 0 0 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2079 2233 False False 0 0 7.19247409791798 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1001 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh c.924C>T ndh_c.924C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.948C>T ndh_c.948C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.-94C>G ndh_c.-94C>G 2 upstream_gene_variant 2103136 NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2133 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1023 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh c.951G>A ndh_c.951G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.-95A>G ndh_c.-95A>G 2 upstream_gene_variant 2103137 1 0 0 0 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2204 2233 False False 0 0 7.19247409791798 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1052 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide ndh c.960G>A ndh_c.960G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.984T>C ndh_c.984T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.984T>G ndh_c.984T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0761899451219867 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh c.996G>C ndh_c.996G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0761899451219867 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide ndh deletion ndh_deletion 2 feature_ablation (see "Genomic_coordinates" sheet) NA 0 0 0 3 1 5209 15486 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.999935429715245 0.999640290494779 0.999998365223265 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 2205 2233 False False 8.91879439431752 0.715852821346612 466.959465949029 0 0 0.000707923512718415 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1053 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 3 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh LoF ndh_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 6 2 4 58 27 5154 15460 0.011128165771297 0.00846062632445397 0.0143622661098765 0.998256602311616 0.997464453982962 0.998850785332127 0.68235294117647 0.572412624985147 0.77916223315453 0.333333333333333 0.0432718682927417 0.777221904496487 0.0689655172413793 0.00846396225300182 0.227661889944486 1.49980597594101 0.13560704990675 10.4683410395431 0.644060255645025 475 2233 False False 6.44361085959844 4.01040748025011 10.5963933416411 0.00038789759503491 4.69796509119909e-05 0.0014005097221091 0.998256602311616 0.997464453982962 0.998850785332127 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 1 6 24 12 2146 3778 0.0110599078341013 0.00709878868381528 0.0164118279598698 0.996833773087071 0.994475777251357 0.998362927167916 0.666666666666666 0.490297453348108 0.814438190174078 0.142857142857142 0.00361029686190058 0.578723197043195 0.0769230769230769 0.00194562849734675 0.360297435267877 0.293414103758931 0.00638011950687145 2.4212666734095 0.433731748625252 216 1065 False False 0 0 0 0 0 0 0 3.52096924510717 1.68908894835428 7.74078572402516 0.000465766185374941 1.17921093194302e-05 0.00259232189678803 0.996833773087071 0.994475777251357 0.998362927167916 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Ala118Val ndh_p.Ala118Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2146 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Ala121Thr ndh_p.Ala121Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 7.19247409791798 0.577090863007554 439 2233 False False 0 0 7.19247409791798 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.2999762698034 0.53686319604546 244.5 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 1 3) Uncertain significance No change no 1 +Ethionamide ndh p.Ala154Val ndh_p.Ala154Val 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 3 5211 15484 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999806289145735 0.999434000080036 0.999960050383188 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2110 2233 False False 0.990468879933474 0.0188633706776044 12.3373543450537 0 0 0.000707651905360176 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Ethionamide ndh p.Ala158Thr ndh_p.Ala158Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2092 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Ala209Val ndh_p.Ala209Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 24 10 5188 15477 0.00460475825019186 0.00295251665001708 0.0068438158240851 0.99935429715245 0.998812851129914 0.999690318343011 0.705882352941176 0.525218939659514 0.849016335576971 NA NA NA 0 0 0.30849710781876 NA NA NA NA 2121 2233 False False 7.15975327679259 3.29721106499659 16.777074277786 0 0 0.000710788028734221 0.99935429715245 0.998812851129914 0.999690318343011 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 24 8 2146 3782 0.0110599078341013 0.00709878868381528 0.0164118279598698 0.997889182058047 0.995845105987758 0.999088271930771 0.75 0.565950625077757 0.885383994897411 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1017 1065 False False 0 0 0 0 0 0 0 5.28704566635601 2.29224820993268 13.6379049058376 0 0 0.00171747938460337 0.997889182058047 0.995845105987758 0.999088271930771 34 3) Uncertain significance No change no 1 +Ethionamide ndh p.Ala219fs ndh_p.Ala219fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2116 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1015 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Ala219Thr ndh_p.Ala219Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ndh p.Ala233Thr ndh_p.Ala233Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ndh p.Ala234Thr ndh_p.Ala234Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2200 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1050 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Ala272Thr ndh_p.Ala272Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ndh p.Ala300Asp ndh_p.Ala300Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ndh p.Ala324fs ndh_p.Ala324fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 1 1 5 4 5207 15483 0.000959324635456638 0.000311561141138009 0.0022373118395626 0.99974171886098 0.999338830952079 0.999929622742193 0.555555555555555 0.212008506778868 0.863004337734833 0.5 0.012579117093425 0.987420882906574 0.2 0.00505076337946806 0.716417936118089 2.97349721528711 0.0378731896327436 232.988102793395 0.440043454009048 377 2233 False False 3.71687151910889 0.799617579523072 18.7336165793798 0.000192012288786482 4.86131844187338e-06 0.00106935456589642 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 3 2167 3787 0.00138248847926267 0.000285193152965682 0.0040348522148252 0.999208443271767 0.997688494809834 0.999836732216022 0.5 0.118117248757025 0.881882751242974 0 0 0.975 0 0 0.707598226178713 0 0 68.1020328189367 1 405 1065 False False 0 0 0 0 0 0 0 1.74757729580064 0.233837130446773 13.0617462404894 0 0 0.00170084976888778 0.999208443271767 0.997688494809834 0.999836732216022 6 3) Uncertain significance No change no 1 +Ethionamide ndh p.Ala325fs ndh_p.Ala325fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 2 1 5210 15486 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 2201 2233 False False 5.9447216890595 0.309382652589367 349.949104522224 0 0 0.000707787682982558 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Ala333Thr ndh_p.Ala333Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Ala336_Gly339del ndh_p.Ala336_Gly339del 2 inframe_deletion (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2206 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1054 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Ala336fs ndh_p.Ala336fs 2 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 4 2 5208 15485 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.99987085943049 0.99953357854254 0.999984360095269 0.666666666666666 0.222778095503512 0.956728131707258 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2134 2233 False False 5.94662058371735 0.851897563491887 65.8224106582454 0 0 0.000708059394597755 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1024 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 NA 3) Uncertain significance No change no 1 +Ethionamide ndh p.Ala340fs ndh_p.Ala340fs 2 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 5209 15487 0.000575594781273983 0.000118717215010897 0.00168120176197813 1 0.999761836368682 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2080 2233 False False Inf 1.22809956796298 Inf 0 0 0.000707923512718415 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1002 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0 0 0.00170006591133688 1 0.999027154404229 1 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Ala340Thr ndh_p.Ala340Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2185 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Ala354Gly ndh_p.Ala354Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Ala371Thr ndh_p.Ala371Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Ala380Val ndh_p.Ala380Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 5212 15483 0 0 0.000707516179821284 0.99974171886098 0.999338830952079 0.999929622742193 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 2202 2233 False False 0 0 4.5014696306354 0 0 0.000707516179821284 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance No change no 1 +Ethionamide ndh p.Ala392Thr ndh_p.Ala392Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2173 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Ala402Val ndh_p.Ala402Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ndh p.Ala44Gly ndh_p.Ala44Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2126 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethionamide ndh p.Ala44Thr ndh_p.Ala44Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2122 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1018 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Ala452Glu ndh_p.Ala452Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2135 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Ala59fs ndh_p.Ala59fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Ala59Val ndh_p.Ala59Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2093 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1008 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Ala9Glu ndh_p.Ala9Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ndh p.Ala9Thr ndh_p.Ala9Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 115.662511114998 1 815 2233 False False 0 0 7.19247409791798 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ndh p.Arg13Leu ndh_p.Arg13Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2147 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Arg150His ndh_p.Arg150His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2081 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Arg16Gln ndh_p.Arg16Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ndh p.Arg202Gln ndh_p.Arg202Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2082 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ndh p.Arg235Gln ndh_p.Arg235Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 115.699581334225 1 815 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ndh p.Arg254Cys ndh_p.Arg254Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 7.19247409791798 0.577090863007554 439 2233 False False 0 0 7.19247409791798 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 1 3) Uncertain significance No change no 1 +Ethionamide ndh p.Arg268His ndh_p.Arg268His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 110 100 5102 15387 0.021105141980046 0.017377006490642 0.0253820978901805 0.993542971524504 0.992152012825067 0.994743306444301 0.523809523809523 0.453959277484022 0.592978153493845 NA NA NA 0 0 0.0362166926451764 NA NA NA NA 2148 2233 False False 3.31746373970991 2.50217580092867 4.40163444922552 0 0 0.000722764836787876 0.993542971524504 0.992152012825067 0.994743306444301 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 10 4 2160 3786 0.00460829493087557 0.00221200142499431 0.00845843813305835 0.998944591029023 0.997299958285064 0.999712364080324 0.714285714285714 0.418964742816338 0.916110681692872 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1027 1065 False False 0 0 0 0 0 0 0 4.38194444444444 1.26164418868893 19.1527250878557 0 0 0.00170635707662357 0.998944591029023 0.997299958285064 0.999712364080324 237 3) Uncertain significance No change no 1 +Ethionamide ndh p.Arg284Trp ndh_p.Arg284Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 5212 15483 0 0 0.000707516179821284 0.99974171886098 0.999338830952079 0.999929622742193 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 2153 2233 False False 0 0 4.5014696306354 0 0 0.000707516179821284 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 2170 3786 0 0 0.00169850036174098 0.998944591029023 0.997299958285064 0.999712364080324 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1030 1065 False False 0 0 0 0 0 0 0 0 0 2.6454264678615 0 0 0.00169850036174098 0.998944591029023 0.997299958285064 0.999712364080324 42 3) Uncertain significance No change no 1 +Ethionamide ndh p.Arg294Gln ndh_p.Arg294Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2219 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1060 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Arg294Trp ndh_p.Arg294Trp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2127 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Arg302fs ndh_p.Arg302fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2123 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1019 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Arg359fs ndh_p.Arg359fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2167 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Arg439Gln ndh_p.Arg439Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2197 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1048 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0 0 0.00170006591133688 1 0.999027154404229 1 3 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Arg441Gln ndh_p.Arg441Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Arg45Cys ndh_p.Arg45Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2094 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ndh p.Asn128Ser ndh_p.Asn128Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2136 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ndh p.Asn28_Ala29delinsLys ndh_p.Asn28_Ala29delinsLys 2 inframe_deletion (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2229 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Asn355fs ndh_p.Asn355fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2087 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1004 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Asp163Glu ndh_p.Asp163Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2203 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1051 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 1 3) Uncertain significance No change no 1 +Ethionamide ndh p.Asp251Ala ndh_p.Asp251Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2137 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ndh p.Asp251Glu ndh_p.Asp251Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2186 2233 False False 0 0 7.19247409791798 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ndh p.Asp288Ala ndh_p.Asp288Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2129 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Asp288fs ndh_p.Asp288fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Asp322Asn ndh_p.Asp322Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2174 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1039 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Asp37fs ndh_p.Asp37fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Asp39Asn ndh_p.Asp39Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Asp93Glu ndh_p.Asp93Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ndh p.Gln10Lys ndh_p.Gln10Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2211 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethionamide ndh p.Gln230His ndh_p.Gln230His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2095 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1009 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 7 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Gln244fs ndh_p.Gln244fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2220 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Gln292Pro ndh_p.Gln292Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2088 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1005 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide ndh p.Gln334fs ndh_p.Gln334fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2175 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1040 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Gln363Ser ndh_p.Gln363Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 5 9 5207 15478 0.000959324635456638 0.000311561141138009 0.0022373118395626 0.999418867437205 0.998897117312968 0.999734235852573 0.357142857142857 0.127598429859159 0.648619889384008 NA NA NA 0 0 0.336267116879942 NA NA NA NA 2187 2233 False False 1.6514094274801 0.434525597785957 5.48973792748775 0 0 0.00070819532865061 0.999418867437205 0.998897117312968 0.999734235852573 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1045 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 33 3) Uncertain significance No change no 1 +Ethionamide ndh p.Gln4fs ndh_p.Gln4fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2176 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Gln97Arg ndh_p.Gln97Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2221 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ndh p.Glu159Lys ndh_p.Glu159Lys 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2149 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Glu194Lys ndh_p.Glu194Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2101 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1013 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Glu270Asp ndh_p.Glu270Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2107 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ndh p.Glu291_Pro312delinsAsp ndh_p.Glu291_Pro312delinsAsp 2 inframe_deletion (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2130 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1022 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Glu327Ala ndh_p.Glu327Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ndh p.Glu350Asp ndh_p.Glu350Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2117 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Glu360Lys ndh_p.Glu360Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2102 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Glu65Lys ndh_p.Glu65Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2222 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1061 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Glu67fs ndh_p.Glu67fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2180 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1042 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Glu6fs ndh_p.Glu6fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 1 2 5211 15485 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2069 2233 False False 1.48579927077336 0.0251793916671698 28.5526337681963 0 0 0.000707651905360176 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 995 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide ndh p.Gly122Ser ndh_p.Gly122Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ndh p.Gly137Asp ndh_p.Gly137Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2083 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Gly179Asp ndh_p.Gly179Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2223 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ndh p.Gly179fs ndh_p.Gly179fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2168 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Gly229Asp ndh_p.Gly229Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2198 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1049 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Gly246Ala ndh_p.Gly246Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2108 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ndh p.Gly246Ser ndh_p.Gly246Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.2999762698034 0.53686319604546 244.5 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Gly301Asp ndh_p.Gly301Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2169 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1036 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 1 3) Uncertain significance No change no 1 +Ethionamide ndh p.Gly301del ndh_p.Gly301del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ndh p.Gly301fs ndh_p.Gly301fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 2 1 5210 15486 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 2070 2233 False False 5.9447216890595 0.309382652589367 349.949104522224 0 0 0.000707787682982558 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 1 2168 3789 0.000921658986175115 0.000111636674590768 0.0033253435449308 0.999736147757256 0.998530795728906 0.999993319861894 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 996 1065 False False 0 0 0 0 0 0 0 3.49538745387453 0.181825522231654 206.012215468794 0 0 0.00170006591133688 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Gly313Arg ndh_p.Gly313Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 19 5212 15468 0 0 0.000707516179821284 0.998773164589655 0.998084804605634 0.999261208414407 0 0 0.176466911806965 NA NA NA 0 0 0.176466911806965 NA NA NA NA 2212 2233 False False 0 0 0.636236572187485 0 0 0.000707516179821284 0.998773164589655 0.998084804605634 0.999261208414407 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 2170 3786 0 0 0.00169850036174098 0.998944591029023 0.997299958285064 0.999712364080324 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1057 1065 False False 0 0 0 0 0 0 0 0 0 2.6454264678615 0 0 0.00169850036174098 0.998944591029023 0.997299958285064 0.999712364080324 83 3) Uncertain significance No change no 1 +Ethionamide ndh p.Gly331Arg ndh_p.Gly331Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 5209 15487 0.000575594781273983 0.000118717215010897 0.00168120176197813 1 0.999761836368682 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2224 2233 False False Inf 1.22809956796298 Inf 0 0 0.000707923512718415 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 2167 3790 0.00138248847926267 0.000285193152965682 0.0040348522148252 1 0.999027154404229 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1062 1065 False False 0 0 0 0 0 0 0 Inf 0.721991535026265 Inf 0 0 0.00170084976888778 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Gly331fs ndh_p.Gly331fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2192 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Gly339Ala ndh_p.Gly339Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2161 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance No change no 1 +Ethionamide ndh p.Gly353Asp ndh_p.Gly353Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2140 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1026 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Gly389Asp ndh_p.Gly389Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2111 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ndh p.Gly389Ser ndh_p.Gly389Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2199 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Gly406Glu ndh_p.Gly406Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2089 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Gly427Ser ndh_p.Gly427Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2084 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ndh p.His106Arg ndh_p.His106Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 10 0 5202 15487 0.00191864927091327 0.000920438305261622 0.00352562450313611 1 0.999761836368682 1 1 0.691502892181239 1 NA NA NA NA NA NA NA NA NA NA 2150 2233 False False Inf 6.6703028343942 Inf 0 0 0.00070887578257034 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 8 0 2162 3790 0.00368663594470046 0.00159293019145598 0.00725115327762171 1 0.999027154404229 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 1028 1065 False False 0 0 0 0 0 0 0 Inf 2.98814511221013 Inf 0 0 0.00170477992420233 1 0.999027154404229 1 29 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.His106dup ndh_p.His106dup 2 inframe_insertion (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2162 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1033 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0 0 0.00170006591133688 1 0.999027154404229 1 2 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.His106fs ndh_p.His106fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 5208 15487 0.00076745970836531 0.000209145270149598 0.00196382534650725 1 0.999761836368682 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2124 2233 False False Inf 1.96217557721065 Inf 0 0 0.000708059394597755 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1020 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.His400Arg ndh_p.His400Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2071 2233 False False 0 0 7.19247409791798 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ndh p.His400Tyr ndh_p.His400Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2163 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Ile204Ser ndh_p.Ile204Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2072 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 997 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Ile20Thr ndh_p.Ile20Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2131 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ndh p.Ile212fs ndh_p.Ile212fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 2 3 5210 15484 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999806289145735 0.999434000080036 0.999960050383188 0.4 0.0527449505263169 0.853367200365326 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2225 2233 False False 1.98131797824696 0.165426255296508 17.2953159846476 0 0 0.000707787682982558 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.2999762698034 0.53686319604546 244.5 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 4 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Ile269Val ndh_p.Ile269Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2170 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ndh p.Ile311Val ndh_p.Ile311Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Ile337fs ndh_p.Ile337fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 5 1 5207 15486 0.000959324635456638 0.000311561141138009 0.0022373118395626 0.999935429715245 0.999640290494779 0.999998365223265 0.833333333333333 0.358765421002325 0.99578925548551 NA NA NA 0 0 0.975 NA NA NA NA 2164 2233 False False 14.8703668139043 1.66317699294464 700.725693531947 0 0 0.00070819532865061 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 2166 3790 0.00184331797235023 0.00050246332413509 0.00471284227984187 1 0.999027154404229 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 1034 1065 False False 0 0 0 0 0 0 0 Inf 1.15374841388447 Inf 0 0 0.00170163434960586 1 0.999027154404229 1 1 3) Uncertain significance No change no 1 +Ethionamide ndh p.Ile62Ser ndh_p.Ile62Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2177 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Ile62Thr ndh_p.Ile62Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2090 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1006 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Ile63Thr ndh_p.Ile63Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2151 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Leu103fs ndh_p.Leu103fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2103 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Leu104fs ndh_p.Leu104fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2138 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Leu170Pro ndh_p.Leu170Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2207 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ndh p.Leu228fs ndh_p.Leu228fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2096 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Leu306Arg ndh_p.Leu306Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Leu309Arg ndh_p.Leu309Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2128 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ndh p.Leu33Pro ndh_p.Leu33Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2157 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Leu399fs ndh_p.Leu399fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2230 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Leu415Pro ndh_p.Leu415Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2085 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Leu42Pro ndh_p.Leu42Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2213 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1058 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Leu54Pro ndh_p.Leu54Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2214 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Leu86fs ndh_p.Leu86fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide ndh p.Lys169Glu ndh_p.Lys169Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2215 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ndh p.Lys227fs ndh_p.Lys227fs 2 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2086 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1003 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 1 3) Uncertain significance No change no 1 +Ethionamide ndh p.Lys274Asn ndh_p.Lys274Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2154 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1031 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide ndh p.Lys460Arg ndh_p.Lys460Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2152 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1029 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Lys460Glu ndh_p.Lys460Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2158 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ndh p.Lys78Asn ndh_p.Lys78Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2182 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Met1? ndh_p.Met1? 2 start_lost (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2226 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ndh p.Phe365Leu ndh_p.Phe365Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2227 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ndh p.Pro111fs ndh_p.Pro111fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2228 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1063 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Pro111His ndh_p.Pro111His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2073 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Ethionamide ndh p.Pro136fs ndh_p.Pro136fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2074 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Pro136Leu ndh_p.Pro136Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2067 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 993 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Pro136Ser ndh_p.Pro136Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2208 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1055 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Pro312Ser ndh_p.Pro312Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ndh p.Pro330_Val332del ndh_p.Pro330_Val332del 2 inframe_deletion (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2216 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1059 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Pro330fs ndh_p.Pro330fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2188 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Pro330Ser ndh_p.Pro330Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2141 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 20 3) Uncertain significance No change no 1 +Ethionamide ndh p.Pro384Arg ndh_p.Pro384Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2193 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Pro70Leu ndh_p.Pro70Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2231 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ndh p.Pro7Leu ndh_p.Pro7Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 5212 15482 0 0 0.000707516179821284 0.999677148576225 0.999246734667469 0.999895162977301 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 4.50117892747928 0.578099153339956 468.5 2233 False False 0 0 3.24289311550326 0 0 0.000707516179821284 0.999677148576225 0.999246734667469 0.999895162977301 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1007 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 7 3) Uncertain significance No change no 1 +Ethionamide ndh p.Ser114Arg ndh_p.Ser114Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2159 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ndh p.Ser140Phe ndh_p.Ser140Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2104 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1014 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide ndh p.Ser206Pro ndh_p.Ser206Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 5 5212 15482 0 0 0.000707516179821284 0.999677148576225 0.999246734667469 0.999895162977301 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 2075 2233 False False 0 0 3.24289311550326 0 0 0.000707516179821284 0.999677148576225 0.999246734667469 0.999895162977301 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 2170 3787 0 0 0.00169850036174098 0.999208443271767 0.997688494809834 0.999836732216022 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 998 1065 False False 0 0 0 0 0 0 0 0 0 4.22663965322398 0 0 0.00169850036174098 0.999208443271767 0.997688494809834 0.999836732216022 2 3) Uncertain significance No change no 1 +Ethionamide ndh p.Ser22Phe ndh_p.Ser22Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ndh p.Ser345Arg ndh_p.Ser345Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ndh p.Ser388Gly ndh_p.Ser388Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2112 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ndh p.Ser423Arg ndh_p.Ser423Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2132 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ndh p.Ser463Asn ndh_p.Ser463Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ndh p.Thr110fs ndh_p.Thr110fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2232 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide ndh p.Thr110Pro ndh_p.Thr110Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2125 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1021 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Thr172Ala ndh_p.Thr172Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2097 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1010 1065 False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 0 0 0.0016992827759538 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Thr172Pro ndh_p.Thr172Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2155 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Thr174Ala ndh_p.Thr174Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ndh p.Thr181Ala ndh_p.Thr181Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ndh p.Thr250Ala ndh_p.Thr250Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2098 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1011 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Thr346Met ndh_p.Thr346Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2099 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1012 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Thr418Ala ndh_p.Thr418Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2194 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Thr420Pro ndh_p.Thr420Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2142 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Thr424Pro ndh_p.Thr424Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2183 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1043 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 7 3) Uncertain significance No change no 1 +Ethionamide ndh p.Thr430fs ndh_p.Thr430fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2160 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1032 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide ndh p.Thr432Pro ndh_p.Thr432Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 5208 15487 0.00076745970836531 0.000209145270149598 0.00196382534650725 1 0.999761836368682 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2195 2233 False False Inf 1.96217557721065 Inf 0 0 0.000708059394597755 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1047 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0 0 0.00170006591133688 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Thr47Ser ndh_p.Thr47Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 0 8 5212 15479 0 0 0.000707516179821284 0.99948343772196 0.998982421476308 0.999776959534822 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 1.74050626415467 0.214442026858522 190.5 2233 False False 0 0 1.74050626415467 0 0 0.000707516179821284 0.99948343772196 0.998982421476308 0.999776959534822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 2170 3787 0 0 0.00169850036174098 0.999208443271767 0.997688494809834 0.999836732216022 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.22663965322398 0.558201069943668 269 1065 False False 0 0 0 0 0 0 0 0 0 4.22663965322398 0 0 0.00169850036174098 0.999208443271767 0.997688494809834 0.999836732216022 9 3) Uncertain significance No change no 1 +Ethionamide ndh p.Thr8fs ndh_p.Thr8fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2217 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Thr8Lys ndh_p.Thr8Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Trp276Cys ndh_p.Trp276Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2100 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Tyr108fs ndh_p.Tyr108fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2171 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1037 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Tyr112fs ndh_p.Tyr112fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 2 2 5210 15485 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.99987085943049 0.99953357854254 0.999984360095269 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2143 2233 False False 2.97216890595009 0.215371636513233 40.9716636776753 0 0 0.000707787682982558 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Tyr112His ndh_p.Tyr112His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2118 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Tyr112* ndh_p.Tyr112* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2113 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Tyr342Asp ndh_p.Tyr342Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Tyr342* ndh_p.Tyr342* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2114 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Tyr364Asp ndh_p.Tyr364Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2209 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ndh p.Tyr56Cys ndh_p.Tyr56Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2190 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Tyr56* ndh_p.Tyr56* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2156 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Val117Gly ndh_p.Val117Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2119 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Val117Ile ndh_p.Val117Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 5212 15483 0 0 0.000707516179821284 0.99974171886098 0.999338830952079 0.999929622742193 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 2091 2233 False False 0 0 4.5014696306354 0 0 0.000707516179821284 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 16 3) Uncertain significance No change no 1 +Ethionamide ndh p.Val176Ile ndh_p.Val176Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2076 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 999 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 1 3) Uncertain significance No change no 1 +Ethionamide ndh p.Val18Ala ndh_p.Val18Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 285 8 277 55 394 5157 15093 0.010552570990023 0.00795925820989337 0.0137137286918515 0.974559307806547 0.971956184207496 0.976982029102494 0.122494432071269 0.0936274525993625 0.156443559613656 0.0280701754385964 0.0121949796434257 0.0545581181069211 0.0199004975124378 0.00862982766362081 0.0388340021723125 0.0845256771315705 0.0360983312836096 0.169067557953 2.48809669551369e-25 9 2233 True False 0.408549711643234 0.301783464023626 0.543869875527512 0.0015488867376573 0.000668929058280975 0.0030496310992402 0.974559307806547 0.971956184207496 0.976982029102494 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 16 0 16 12 30 2158 3760 0.00552995391705069 0.00286057468269438 0.00963977234551449 0.992084432717678 0.988719171683225 0.994653211093733 0.285714285714285 0.157191466765745 0.445838803307969 0 0 0.205907214207822 0 0 0.115703308222027 0 0 0.452390997160164 0.00102676005908631 18 1065 False False 0 0 0 0 0 0 0 0.696941612604263 0.324270435844024 1.40535689078473 0 0 0.00170793714990568 0.992084432717678 0.988719171683225 0.994653211093733 920 3) Uncertain significance No change no 1 +Ethionamide ndh p.Val220Leu ndh_p.Val220Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2115 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ndh p.Val241Ala ndh_p.Val241Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2105 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Val241Gly ndh_p.Val241Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2210 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1056 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Val317Met ndh_p.Val317Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2165 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Val326fs ndh_p.Val326fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2166 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1035 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Val326Met ndh_p.Val326Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2109 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide ndh p.Val332fs ndh_p.Val332fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2189 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Val332Gly ndh_p.Val332Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2077 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Val373Phe ndh_p.Val373Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide ndh p.Val74Leu ndh_p.Val74Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide ndh p.Val99Ala ndh_p.Val99Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2144 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv0565c c.1011C>A Rv0565c_c.1011C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0761899451219867 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.1020C>T Rv0565c_c.1020C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.1044G>T Rv0565c_c.1044G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 5 1 5207 15486 0.000959324635456638 0.000311561141138009 0.0022373118395626 0.999935429715245 0.999640290494779 0.999998365223265 0.833333333333333 0.358765421002325 0.99578925548551 NA NA NA NA NA NA NA NA NA NA NA NA False False 14.8703668139043 1.66317699294464 700.725693531947 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.-10G>A Rv0565c_c.-10G>A 2 upstream_gene_variant 657480 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1763 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c c.-10G>T Rv0565c_c.-10G>T 2 upstream_gene_variant 657480 NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1844 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 885 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c c.1101T>G Rv0565c_c.1101T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0761899451219867 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.1104G>A Rv0565c_c.1104G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.1104G>T Rv0565c_c.1104G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.1113T>C Rv0565c_c.1113T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.111C>T Rv0565c_c.111C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.1164G>A Rv0565c_c.1164G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.1189C>T Rv0565c_c.1189C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.-11C>A Rv0565c_c.-11C>A 2 upstream_gene_variant 657481 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c c.1210C>A Rv0565c_c.1210C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.1218G>A Rv0565c_c.1218G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 5 5210 15482 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999677148576225 0.999246734667469 0.999895162977301 0.285714285714285 0.0366925661760855 0.709579136262657 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.18863723608445 0.113129903278746 7.26455938498844 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 2 2168 3788 0.000921658986175115 0.000111636674590768 0.0033253435449308 0.999472295514512 0.998095063429584 0.999936086148442 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.74723247232472 0.126540110696744 24.1244851777313 NA NA NA NA NA NA 28 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.1245C>G Rv0565c_c.1245C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 10 0 5202 15487 0.00191864927091327 0.000920438305261622 0.00352562450313611 1 0.999761836368682 1 1 0.691502892181239 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 6.6703028343942 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 8 0 2162 3790 0.00368663594470046 0.00159293019145598 0.00725115327762171 1 0.999027154404229 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 2.98814511221013 Inf NA NA NA NA NA NA 29 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.1248T>C Rv0565c_c.1248T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.1263C>G Rv0565c_c.1263C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.1273C>T Rv0565c_c.1273C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0761899451219867 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.1302G>A Rv0565c_c.1302G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.1317G>A Rv0565c_c.1317G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.132G>T Rv0565c_c.132G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.1332G>A Rv0565c_c.1332G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.1335G>T Rv0565c_c.1335G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.1359C>T Rv0565c_c.1359C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0761899451219867 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.1365C>T Rv0565c_c.1365C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 3 5210 15484 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999806289145735 0.999434000080036 0.999960050383188 0.4 0.0527449505263169 0.853367200365326 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.98131797824696 0.165426255296508 17.2953159846476 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf NA NA NA NA NA NA 11 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.1371G>A Rv0565c_c.1371G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0761899451219867 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.1374G>A Rv0565c_c.1374G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.-13A>C Rv0565c_c.-13A>C 2 upstream_gene_variant 657483 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1826 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c c.1419A>G Rv0565c_c.1419A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.1428C>A Rv0565c_c.1428C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.144C>A Rv0565c_c.144C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 9 5210 15478 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999418867437205 0.998897117312968 0.999734235852573 0.181818181818181 0.0228311982999596 0.517755852360172 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.660183407976114 0.0693911990938747 3.19086066213761 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.168C>T Rv0565c_c.168C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 8 5208 15479 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.99948343772196 0.998982421476308 0.999776959534822 0.333333333333333 0.0992460911495833 0.651124493581186 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.48607910906298 0.327343181309975 5.54928881094045 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 1 2167 3789 0.00138248847926267 0.000285193152965682 0.0040348522148252 0.999736147757256 0.998530795728906 0.999993319861894 0.75 0.194120449683243 0.99369053679029 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 5.2455006922012 0.420751345257316 275.029142692281 NA NA NA NA NA NA 100 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.204G>A Rv0565c_c.204G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.210C>A Rv0565c_c.210C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.-23C>G Rv0565c_c.-23C>G 2 upstream_gene_variant 657493 1 0 0 0 0 5 5212 15482 0 0 0.000707516179821284 0.999677148576225 0.999246734667469 0.999895162977301 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1989 2233 False False 0 0 3.24289311550326 0 0 0.000707516179821284 0.999677148576225 0.999246734667469 0.999895162977301 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 956 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 4 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c c.246C>T Rv0565c_c.246C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0761899451219867 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.24C>T Rv0565c_c.24C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0761899451219867 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.261C>T Rv0565c_c.261C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.267C>T Rv0565c_c.267C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.-27G>A Rv0565c_c.-27G>A 2 upstream_gene_variant 657497 NA 0 0 0 5 0 5207 15487 0.000959324635456638 0.000311561141138009 0.0022373118395626 1 0.999761836368682 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 1923 2233 False False Inf 2.72427826476923 Inf 0 0 0.00070819532865061 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c c.309C>T Rv0565c_c.309C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.2999762698034 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.351C>G Rv0565c_c.351C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.357T>C Rv0565c_c.357T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 7 5209 15480 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.999548008006715 0.999068946905294 0.99981825708278 0.3 0.0667395111777345 0.652452850059997 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.27361983380413 0.212438830534513 5.58065374082854 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 2 2167 3788 0.00138248847926267 0.000285193152965682 0.0040348522148252 0.999472295514512 0.998095063429584 0.999936086148442 0.6 0.146632799634673 0.947255049473683 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.62205814490078 0.300049946119759 31.4084209142753 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.360C>T Rv0565c_c.360C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.366C>T Rv0565c_c.366C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0761899451219867 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.372C>T Rv0565c_c.372C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 6 5210 15481 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.99961257829147 0.999156938222445 0.999857810215121 0.25 0.0318540262499442 0.650855794412824 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.990467050543826 0.097726046324841 5.54070950742461 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.-37C>A Rv0565c_c.-37C>A 2 upstream_gene_variant 657507 0 0 0 0 3 14 5209 15473 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.99909601601343 0.998483733164878 0.999505698211522 0.176470588235294 0.0379850680706259 0.434317872844283 NA NA NA 0 0 0.231635761650116 NA NA NA NA 1868 2233 False False 0.636521953761347 0.117270163072219 2.28193561615322 0 0 0.000707923512718415 0.99909601601343 0.998483733164878 0.999505698211522 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 8 2168 3782 0.000921658986175115 0.000111636674590768 0.0033253435449308 0.997889182058047 0.995845105987758 0.999088271930771 0.2 0.0252107263268333 0.556095462307641 NA NA NA 0 0 0.369416647552819 NA NA NA NA 896 1065 False False 0 0 0 0 0 0 0 0.436116236162361 0.0450846738492974 2.18833289825467 0 0 0.00170006591133688 0.997889182058047 0.995845105987758 0.999088271930771 11 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c c.390G>A Rv0565c_c.390G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2774 7120 2438 8367 0.532233307751343 0.518576489275465 0.545854001666767 0.540259572544714 0.53237120137132 0.548132815239133 0.280371942591469 0.271536270708286 0.289337062628359 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.33709581900802 1.25491074496932 1.42466556552784 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1123 2017 1047 1773 0.517511520737327 0.496245141484026 0.53873054298453 0.467810026385224 0.451822761639576 0.483846976707828 0.35764331210191 0.34085845527728 0.374693773756462 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.942835468716482 0.847093921908567 1.04941021432941 NA NA NA NA NA NA 12601 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.396G>A Rv0565c_c.396G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.97179044329303 0.0378514560716107 232.854636669753 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.405C>T Rv0565c_c.405C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 8 5210 15479 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.99948343772196 0.998982421476308 0.999776959534822 0.2 0.0252107263268333 0.556095462307641 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.742754318618042 0.0768154930687216 3.72386552333142 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 5 2169 3785 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.998680738786279 0.996923992057454 0.999571505100005 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.349008759797141 0.00737988563135068 3.12211888418912 NA NA NA NA NA NA 48 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.408C>T Rv0565c_c.408C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.423C>T Rv0565c_c.423C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.435C>T Rv0565c_c.435C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.441C>T Rv0565c_c.441C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0761899451219867 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf NA NA NA NA NA NA 13 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.447C>T Rv0565c_c.447C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.450G>A Rv0565c_c.450G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 3 5209 15484 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.999806289145735 0.999434000080036 0.999960050383188 0.5 0.118117248757025 0.881882751242974 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.97254751391821 0.397987980392264 22.1986618481397 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.465C>T Rv0565c_c.465C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0761899451219867 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.519A>C Rv0565c_c.519A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.51C>T Rv0565c_c.51C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.97179044329303 0.0378514560716107 232.854636669753 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.528G>A Rv0565c_c.528G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.531C>T Rv0565c_c.531C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0761899451219867 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.537C>T Rv0565c_c.537C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.561C>T Rv0565c_c.561C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.-56G>A Rv0565c_c.-56G>A 2 upstream_gene_variant 657526 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c c.573C>T Rv0565c_c.573C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.576G>A Rv0565c_c.576G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.588C>T Rv0565c_c.588C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 3 5211 15484 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999806289145735 0.999434000080036 0.999960050383188 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.990468879933474 0.0188633706776044 12.3373543450537 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.591C>A Rv0565c_c.591C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.97179044329303 0.0378514560716107 232.854636669753 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.595C>T Rv0565c_c.595C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.-60G>C Rv0565c_c.-60G>C 2 upstream_gene_variant 657530 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1976 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 949 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c c.-61G>A Rv0565c_c.-61G>A 2 upstream_gene_variant 657531 1 0 0 0 0 5 5212 15482 0 0 0.000707516179821284 0.999677148576225 0.999246734667469 0.999895162977301 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1939 2233 False False 0 0 3.24289311550326 0 0 0.000707516179821284 0.999677148576225 0.999246734667469 0.999895162977301 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 28 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c c.630G>A Rv0565c_c.630G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 20 5212 15467 0 0 0.000707516179821284 0.9987085943049 0.998006229813624 0.999211003011252 0 0 0.168433470983085 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.601367187047131 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 10 2170 3780 0 0 0.00169850036174098 0.997361477572559 0.995153033699313 0.99873402334933 0 0 0.30849710781876 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.778110309621997 NA NA NA NA NA NA 16 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.639G>A Rv0565c_c.639G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 44 5208 15443 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.997158907470782 0.996187821963928 0.997934922010617 0.0833333333333333 0.023173495136761 0.19982801419938 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.269567797793604 0.0703413213047045 0.74107735562133 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 21 2167 3769 0.00138248847926267 0.000285193152965682 0.0040348522148252 0.994459102902374 0.991542558159884 0.996566923060264 0.125 0.0265593149862489 0.323611358188833 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.248467268771837 0.0474125390456008 0.83370248671357 NA NA NA NA NA NA 57 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.-64G>A Rv0565c_c.-64G>A 2 upstream_gene_variant 657534 1 0 0 0 2 1 5210 15486 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 1892 2233 False False 5.9447216890595 0.309382652589367 349.949104522224 0 0 0.000707787682982558 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 910 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 3 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c c.666C>T Rv0565c_c.666C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.681C>T Rv0565c_c.681C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.-69A>G Rv0565c_c.-69A>G 2 upstream_gene_variant 657539 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1740 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c c.702T>C Rv0565c_c.702T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.19247409791798 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.738C>T Rv0565c_c.738C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.19247409791798 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.756G>C Rv0565c_c.756G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.786G>A Rv0565c_c.786G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.-7G>A Rv0565c_c.-7G>A 2 upstream_gene_variant 657477 NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1877 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c c.804G>A Rv0565c_c.804G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.81G>A Rv0565c_c.81G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.864G>A Rv0565c_c.864G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.873C>T Rv0565c_c.873C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.97179044329303 0.0378514560716107 232.854636669753 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.891G>A Rv0565c_c.891G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.894C>T Rv0565c_c.894C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.915G>A Rv0565c_c.915G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.915G>C Rv0565c_c.915G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.97179044329303 0.0378514560716107 232.854636669753 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.921C>T Rv0565c_c.921C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.948G>C Rv0565c_c.948G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.960T>C Rv0565c_c.960T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.984T>C Rv0565c_c.984T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.999C>G Rv0565c_c.999C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0761899451219867 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv0565c c.-9A>C Rv0565c_c.-9A>C 2 upstream_gene_variant 657479 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1817 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c LoF Rv0565c_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 8 0 8 162 225 5050 15262 0.031082118188795 0.0265389877330761 0.0361598001732661 0.985471685930134 0.983461002108855 0.987296846584508 0.41860465116279 0.368949986048431 0.469513912503162 0 0 0.369416647552819 0 0 0.0162613529461631 0 0 1.77115292221242 0.213393193585289 189 2233 False False 2.17596831683168 1.76230887613106 2.68189984631872 0 0 0.000730204449910696 0.985471685930134 0.983461002108855 0.987296846584508 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 60 65 2110 3725 0.0276497695852534 0.0211645253100205 0.0354488479248319 0.982849604221636 0.978192016128404 0.98673939131756 0.48 0.389836056609659 0.571133268157967 0 0 0.975 0 0 0.0551716343188133 0 0 68.7962389173731 1 405 1065 False False 0 0 0 0 0 0 0 1.62960262486328 1.12293945637275 2.36099345062921 0 0 0.00174675674304121 0.982849604221636 0.978192016128404 0.98673939131756 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ala190Thr Rv0565c_p.Ala190Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 2 5210 15485 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.99987085943049 0.99953357854254 0.999984360095269 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1860 2233 False False 2.97216890595009 0.215371636513233 40.9716636776753 0 0 0.000707787682982558 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 2 2168 3788 0.000921658986175115 0.000111636674590768 0.0033253435449308 0.999472295514512 0.998095063429584 0.999936086148442 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 892 1065 False False 0 0 0 0 0 0 0 1.74723247232472 0.126540110696744 24.1244851777313 0 0 0.00170006591133688 0.999472295514512 0.998095063429584 0.999936086148442 2 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ala192Thr Rv0565c_p.Ala192Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 4 1 5208 15486 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.999935429715245 0.999640290494779 0.999998365223265 0.8 0.28358206388191 0.994949236620532 NA NA NA 0 0 0.975 NA NA NA NA 1795 2233 False False 11.8940092165898 1.17652678598182 583.885453446482 0 0 0.000708059394597755 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 2167 3790 0.00138248847926267 0.000285193152965682 0.0040348522148252 1 0.999027154404229 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 861 1065 False False 0 0 0 0 0 0 0 Inf 0.721991535026265 Inf 0 0 0.00170084976888778 1 0.999027154404229 1 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ala192Val Rv0565c_p.Ala192Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1981 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 952 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ala203Ser Rv0565c_p.Ala203Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 5212 15483 0 0 0.000707516179821284 0.99974171886098 0.999338830952079 0.999929622742193 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1796 2233 False False 0 0 4.5014696306354 0 0 0.000707516179821284 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 862 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 8 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ala226fs Rv0565c_p.Ala226fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1808 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 870 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ala226Gly Rv0565c_p.Ala226Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1785 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ala227Val Rv0565c_p.Ala227Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1940 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ala24fs Rv0565c_p.Ala24fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1893 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 911 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ala25fs Rv0565c_p.Ala25fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1951 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ala25Gly Rv0565c_p.Ala25Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ala272Thr Rv0565c_p.Ala272Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1883 2233 False False 0 0 7.19247409791798 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ala272Val Rv0565c_p.Ala272Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0447829748447436 Inf 0.364093959731543 164 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ala308Val Rv0565c_p.Ala308Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 115.699581334225 1 815 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ala330Pro Rv0565c_p.Ala330Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1952 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 936 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ala345Thr Rv0565c_p.Ala345Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1941 2233 False False 0 0 7.19247409791798 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 2170 3787 0 0 0.00169850036174098 0.999208443271767 0.997688494809834 0.999836732216022 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 930 1065 False False 0 0 0 0 0 0 0 0 0 4.22663965322398 0 0 0.00169850036174098 0.999208443271767 0.997688494809834 0.999836732216022 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ala352fs Rv0565c_p.Ala352fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 5209 15487 0.000575594781273983 0.000118717215010897 0.00168120176197813 1 0.999761836368682 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1827 2233 False False Inf 1.22809956796298 Inf 0 0 0.000707923512718415 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ala356fs Rv0565c_p.Ala356fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1900 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ala393Pro Rv0565c_p.Ala393Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1777 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 853 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ala399Thr Rv0565c_p.Ala399Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1990 2233 False False 0 0 7.19247409791798 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ala403fs Rv0565c_p.Ala403fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 1 5210 15486 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 1982 2233 False False 5.9447216890595 0.309382652589367 349.949104522224 0 0 0.000707787682982558 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 953 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0 0 0.00170006591133688 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ala403Thr Rv0565c_p.Ala403Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1908 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ala407Ser Rv0565c_p.Ala407Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1845 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 886 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ala415fs Rv0565c_p.Ala415fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1846 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ala421fs Rv0565c_p.Ala421fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1869 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ala449fs Rv0565c_p.Ala449fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1749 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ala449Glu Rv0565c_p.Ala449Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1850 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ala449Thr Rv0565c_p.Ala449Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 3 5211 15484 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999806289145735 0.999434000080036 0.999960050383188 0.25 0.00630946320970987 0.805879550316756 0 0 0.975 0 0 0.707598226178713 0 0 115.684666832268 1 496.5 2233 False False 0.990468879933474 0.0188633706776044 12.3373543450537 0 0 0.000707651905360176 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 2 2169 3788 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999472295514512 0.998095063429584 0.999936086148442 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 931 1065 False False 0 0 0 0 0 0 0 0.87321346242508 0.0147995228023146 16.7833115850342 0 0 0.0016992827759538 0.999472295514512 0.998095063429584 0.999936086148442 10 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ala467Val Rv0565c_p.Ala467Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1778 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ala81Thr Rv0565c_p.Ala81Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1772 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ala84fs Rv0565c_p.Ala84fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1958 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Arg110His Rv0565c_p.Arg110His 2 missense_variant (see "Genomic_coordinates" sheet) 1 3216 102 3114 2552 5324 2660 10163 0.489639293937068 0.475981033827003 0.503309165312888 0.656227803964615 0.648686274831204 0.663710611198881 0.324022346368715 0.313689622056658 0.334485435760344 0.0317164179104477 0.0259333699924559 0.0383702270830199 0.0187983781791374 0.0153531670028896 0.0227739134560983 0.125147406087473 0.101243956039665 0.153228086832243 7.26849279844976e-162 3 2233 True False 1.83139874479587 1.71751084996129 1.95278246269159 0.0369297610427226 0.0302101588206528 0.044651979664206 0.656227803964615 0.648686274831204 0.663710611198881 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 904 55 849 1060 1744 1110 2046 0.488479262672811 0.467244827213449 0.509744853903757 0.539841688654353 0.523816414592907 0.555805465896626 0.378031383737517 0.360040579910862 0.396277152236749 0.0608407079646017 0.0461588090298563 0.0784594918708366 0.0305725403001667 0.0231126976121842 0.0396100791451876 0.119409161811988 0.0883778565897947 0.158713807282398 1.17187939378627e-79 1 1065 True False 0 0 0 0 0 0 0 1.12031986114554 1.00652914367746 1.24696543455381 0.0472103004291845 0.035760180550727 0.0610101937620206 0.539841688654353 0.523816414592907 0.555805465896626 8603 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Arg135Cys Rv0565c_p.Arg135Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Arg137Trp Rv0565c_p.Arg137Trp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1878 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 903 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Arg202Trp Rv0565c_p.Arg202Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1750 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Arg243Leu Rv0565c_p.Arg243Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1809 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 871 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Arg270His Rv0565c_p.Arg270His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Arg27Trp Rv0565c_p.Arg27Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 4 5210 15483 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.99974171886098 0.999338830952079 0.999929622742193 0.333333333333333 0.0432718682927417 0.777221904496487 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1756 2233 False False 1.48589251439539 0.134348817103157 10.3711983427491 0 0 0.000707787682982558 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 3 2169 3787 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999208443271767 0.997688494809834 0.999836732216022 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 842 1065 False False 0 0 0 0 0 0 0 0.581988627631781 0.0110856993615618 7.25404417491437 0 0 0.0016992827759538 0.999208443271767 0.997688494809834 0.999836732216022 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Arg289Gln Rv0565c_p.Arg289Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1912 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Arg296Gln Rv0565c_p.Arg296Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1786 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 856 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Arg31fs Rv0565c_p.Arg31fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Arg31Gly Rv0565c_p.Arg31Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1942 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Arg368Gln Rv0565c_p.Arg368Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 3 5210 15484 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999806289145735 0.999434000080036 0.999960050383188 0.4 0.0527449505263169 0.853367200365326 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1924 2233 False False 1.98131797824696 0.165426255296508 17.2953159846476 0 0 0.000707787682982558 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Arg368Trp Rv0565c_p.Arg368Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Arg398His Rv0565c_p.Arg398His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1764 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Arg398Leu Rv0565c_p.Arg398Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1861 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Arg43His Rv0565c_p.Arg43His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1901 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 916 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Arg445Trp Rv0565c_p.Arg445Trp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1991 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 957 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Arg457Gln Rv0565c_p.Arg457Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1765 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Arg45Gln Rv0565c_p.Arg45Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1913 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Arg45Pro Rv0565c_p.Arg45Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1766 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Arg45Trp Rv0565c_p.Arg45Trp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1818 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Arg462* Rv0565c_p.Arg462* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 4 1 5208 15486 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.999935429715245 0.999640290494779 0.999998365223265 0.8 0.28358206388191 0.994949236620532 NA NA NA 0 0 0.975 NA NA NA NA 1902 2233 False False 11.8940092165898 1.17652678598182 583.885453446482 0 0 0.000708059394597755 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 917 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0 0 0.00170006591133688 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Arg54Cys Rv0565c_p.Arg54Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1903 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 918 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Arg54Gly Rv0565c_p.Arg54Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1983 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Arg59His Rv0565c_p.Arg59His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1943 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Arg76Cys Rv0565c_p.Arg76Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1925 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 925 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0 0 0.00170006591133688 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Asn291His Rv0565c_p.Asn291His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 5 5212 15482 0 0 0.000707516179821284 0.999677148576225 0.999246734667469 0.999895162977301 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1797 2233 False False 0 0 3.24289311550326 0 0 0.000707516179821284 0.999677148576225 0.999246734667469 0.999895162977301 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 863 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Asn32Ser Rv0565c_p.Asn32Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1944 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Asn383Asp Rv0565c_p.Asn383Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1894 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 912 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 2 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Asn383Thr Rv0565c_p.Asn383Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 14 0 14 0 15 5212 15472 0 0 0.000707516179821284 0.999031445728675 0.998403019382043 0.999457809400789 0 0 0.218019360910534 0 0 0.231635761650116 0 0 0.218019360910534 0 0 0.895344835632628 0.0279658840541847 89 2233 False False 0 0 0.82801706712187 0 0 0.000707516179821284 0.999031445728675 0.998403019382043 0.999457809400789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 14 0 14 0 15 2170 3775 0 0 0.00169850036174098 0.996042216358839 0.993480626422322 0.997783218170708 0 0 0.218019360910534 0 0 0.231635761650116 0 0 0.218019360910534 0 0 0.525147591210095 0.0033474718514349 23 1065 False False 0 0 0 0 0 0 0 0 0 0.485669054315938 0 0 0.00169850036174098 0.996042216358839 0.993480626422322 0.997783218170708 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Asn392fs Rv0565c_p.Asn392fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1992 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Asp100Gly Rv0565c_p.Asp100Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1773 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Asp115Ala Rv0565c_p.Asp115Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1862 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Asp149fs Rv0565c_p.Asp149fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1945 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Asp155fs Rv0565c_p.Asp155fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1779 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Asp155Glu Rv0565c_p.Asp155Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1914 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Asp281Ala Rv0565c_p.Asp281Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1870 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 897 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Asp281Glu Rv0565c_p.Asp281Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1934 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Asp294Gly Rv0565c_p.Asp294Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1926 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Asp319Ala Rv0565c_p.Asp319Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1828 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Asp319Tyr Rv0565c_p.Asp319Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1741 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 833 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Asp369Asn Rv0565c_p.Asp369Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Asp380Glu Rv0565c_p.Asp380Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1959 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 938 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Asp380Gly Rv0565c_p.Asp380Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 5212 15483 0 0 0.000707516179821284 0.99974171886098 0.999338830952079 0.999929622742193 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 4.5014696306354 0.578098957200874 462.5 2233 False False 0 0 4.5014696306354 0 0 0.000707516179821284 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 16 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Asp400Glu Rv0565c_p.Asp400Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1927 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 926 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Asp400Gly Rv0565c_p.Asp400Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1928 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 927 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Asp427Asn Rv0565c_p.Asp427Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Asp431Ala Rv0565c_p.Asp431Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Asp431Asn Rv0565c_p.Asp431Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 3 5211 15484 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999806289145735 0.999434000080036 0.999960050383188 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1879 2233 False False 0.990468879933474 0.0188633706776044 12.3373543450537 0 0 0.000707651905360176 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 904 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 10 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Asp475Asn Rv0565c_p.Asp475Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Asp51Glu Rv0565c_p.Asp51Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1895 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Asp61Gly Rv0565c_p.Asp61Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 5 5212 15482 0 0 0.000707516179821284 0.999677148576225 0.999246734667469 0.999895162977301 0 0 0.521823750104981 0 0 0.975 0 0 0.521823750104981 0 0 115.647599457306 1 815 2233 False False 0 0 3.24289311550326 0 0 0.000707516179821284 0.999677148576225 0.999246734667469 0.999895162977301 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 4 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Cys298Arg Rv0565c_p.Cys298Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 5209 15487 0.000575594781273983 0.000118717215010897 0.00168120176197813 1 0.999761836368682 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1896 2233 False False Inf 1.22809956796298 Inf 0 0 0.000707923512718415 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 913 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 2 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Cys387Tyr Rv0565c_p.Cys387Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1863 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 893 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Gln34Arg Rv0565c_p.Gln34Arg 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 26 5211 15461 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.998321172596371 0.997541089641407 0.998903050216343 0.037037037037037 0.000937257091944708 0.189705617413044 NA NA NA 0 0 0.132274604497754 NA NA NA NA 1960 2233 False False 0.114115111524437 0.00278683951714502 0.695023637792103 0 0 0.000707651905360176 0.998321172596371 0.997541089641407 0.998903050216343 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 11 2169 3779 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.997097625329815 0.994812797611582 0.998550282198211 0.0833333333333333 0.00210759323186022 0.384796165150944 NA NA NA 0 0 0.284914152918154 NA NA NA NA 939 1065 False False 0 0 0 0 0 0 0 0.158388867932436 0.00368218854331032 1.09131512710414 0 0 0.0016992827759538 0.997097625329815 0.994812797611582 0.998550282198211 148 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Gln351* Rv0565c_p.Gln351* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1909 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 920 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Gln439Pro Rv0565c_p.Gln439Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1851 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 889 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Glu150Val Rv0565c_p.Glu150Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 5212 15483 0 0 0.000707516179821284 0.99974171886098 0.999338830952079 0.999929622742193 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1969 2233 False False 0 0 4.5014696306354 0 0 0.000707516179821284 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Glu160Asp Rv0565c_p.Glu160Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1946 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Glu30Lys Rv0565c_p.Glu30Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1798 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Glu315fs Rv0565c_p.Glu315fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1819 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 876 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Glu41Lys Rv0565c_p.Glu41Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Glu428Asp Rv0565c_p.Glu428Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1993 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Gly144Ala Rv0565c_p.Gly144Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1742 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 834 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Gly151Arg Rv0565c_p.Gly151Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1977 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Gly151Asp Rv0565c_p.Gly151Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1915 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 922 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Gly158Arg Rv0565c_p.Gly158Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1780 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Gly164Val Rv0565c_p.Gly164Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1774 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 851 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Gly16fs Rv0565c_p.Gly16fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1880 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 905 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Gly16Ser Rv0565c_p.Gly16Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 115 1 114 55 169 5157 15318 0.010552570990023 0.00795925820989337 0.0137137286918515 0.989087621876412 0.987323972223357 0.990663750134664 0.245535714285714 0.190649494759496 0.307290105113022 0.00869565217391304 0.000220130619736184 0.0474969468849952 0.00588235294117647 0.000148917192994408 0.0323370660605054 0.0260555402467775 0.000658423658747884 0.148232378791007 2.91118156132121e-13 10 2233 True False 0.966675960634881 0.698506878056098 1.32004756704713 0.00019387359441644 4.90844239021676e-06 0.00107971595307994 0.989087621876412 0.987323972223357 0.990663750134664 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 28 1 27 22 35 2148 3755 0.0101382488479262 0.00636418552369621 0.0153094100827514 0.990765171503957 0.987179785497929 0.993559412395983 0.385964912280701 0.259954680998122 0.524251584756488 0.0357142857142857 0.000903798755658059 0.183477597544623 0.0277777777777777 0.00070302520590478 0.145289264746853 0.0647458445410028 0.0015849067474396 0.393491760877944 8.79573059932114e-05 14 1065 True False 0 0 0 0 0 0 0 1.09882947592444 0.612344157280619 1.93211460823417 0.000465332712889716 1.17811348756359e-05 0.00258991187821526 0.990765171503957 0.987179785497929 0.993559412395983 222 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Gly189Arg Rv0565c_p.Gly189Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1904 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Gly189Glu Rv0565c_p.Gly189Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1787 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 857 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Gly21Glu Rv0565c_p.Gly21Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Gly279Ser Rv0565c_p.Gly279Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1970 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 946 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 2 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Gly312Val Rv0565c_p.Gly312Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1871 2233 False False 0 0 7.19247409791798 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Gly328Asp Rv0565c_p.Gly328Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1884 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 906 1065 False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 0 0 0.0016992827759538 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Gly335Glu Rv0565c_p.Gly335Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1799 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 864 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 5 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Gly347Asp Rv0565c_p.Gly347Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 1 5210 15486 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 1885 2233 False False 5.9447216890595 0.309382652589367 349.949104522224 0 0 0.000707787682982558 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 907 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0 0 0.00170006591133688 1 0.999027154404229 1 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Gly347Ser Rv0565c_p.Gly347Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 10 5212 15477 0 0 0.000707516179821284 0.99935429715245 0.998812851129914 0.999690318343011 0 0 0.30849710781876 0 0 0.841886116991581 0 0 0.30849710781876 0 0 15.8151276476713 1 815 2233 False False 0 0 1.32532562767373 0 0 0.000707516179821284 0.99935429715245 0.998812851129914 0.999690318343011 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 59 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Gly355Arg Rv0565c_p.Gly355Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 7 5212 15480 0 0 0.000707516179821284 0.999548008006715 0.999068946905294 0.99981825708278 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 2.52341447917258 0.347653302715337 366.5 2233 False False 0 0 2.06147084147984 0 0 0.000707516179821284 0.999548008006715 0.999068946905294 0.99981825708278 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 2170 3785 0 0 0.00169850036174098 0.998680738786279 0.996923992057454 0.999571505100005 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.90544972133019 0.166077409028393 71 1065 False False 0 0 0 0 0 0 0 0 0 1.90544972133019 0 0 0.00169850036174098 0.998680738786279 0.996923992057454 0.999571505100005 2 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Gly355Glu Rv0565c_p.Gly355Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 2 5211 15485 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1947 2233 False False 1.48579927077336 0.0251793916671698 28.5526337681963 0 0 0.000707651905360176 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 2 2169 3788 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999472295514512 0.998095063429584 0.999936086148442 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 932 1065 False False 0 0 0 0 0 0 0 0.87321346242508 0.0147995228023146 16.7833115850342 0 0 0.0016992827759538 0.999472295514512 0.998095063429584 0.999936086148442 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Gly362fs Rv0565c_p.Gly362fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1852 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Gly362Ser Rv0565c_p.Gly362Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 115.669966941234 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Gly417Arg Rv0565c_p.Gly417Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1994 2233 False False 0 0 7.19247409791798 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Gly426fs Rv0565c_p.Gly426fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1836 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Gly441Cys Rv0565c_p.Gly441Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Gly47Ala Rv0565c_p.Gly47Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1820 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Gly47Ser Rv0565c_p.Gly47Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1948 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 933 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Gly48Asp Rv0565c_p.Gly48Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1788 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 858 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 5 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Gly57Cys Rv0565c_p.Gly57Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1961 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 940 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 4 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Gly57Ser Rv0565c_p.Gly57Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 5210 15486 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 115.721748393509 1 815 2233 False False 5.9447216890595 0.309382652589367 349.949104522224 0 0 0.000707787682982558 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 847 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0 0 0.00170006591133688 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Gly83Ala Rv0565c_p.Gly83Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 2 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Gly83del Rv0565c_p.Gly83del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Gly8Ser Rv0565c_p.Gly8Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 33 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.His133fs Rv0565c_p.His133fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1751 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.His168fs Rv0565c_p.His168fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1930 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.His168Tyr Rv0565c_p.His168Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1929 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 928 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.His171Arg Rv0565c_p.His171Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1847 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.His171Pro Rv0565c_p.His171Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1757 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.His285Pro Rv0565c_p.His285Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1743 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 835 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.His320Tyr Rv0565c_p.His320Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1800 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 865 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.His376Pro Rv0565c_p.His376Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1886 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.His412Arg Rv0565c_p.His412Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 5210 15486 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 115.721748393509 1 815 2233 False False 5.9447216890595 0.309382652589367 349.949104522224 0 0 0.000707787682982558 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.His412Asn Rv0565c_p.His412Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1864 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 894 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.His416Tyr Rv0565c_p.His416Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1781 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.His424Pro Rv0565c_p.His424Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1837 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.His95Asp Rv0565c_p.His95Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 3 5211 15484 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999806289145735 0.999434000080036 0.999960050383188 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1905 2233 False False 0.990468879933474 0.0188633706776044 12.3373543450537 0 0 0.000707651905360176 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 919 1065 False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 0 0 0.0016992827759538 0.999736147757256 0.998530795728906 0.999993319861894 2 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ile196Leu Rv0565c_p.Ile196Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1887 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 908 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ile241Asn Rv0565c_p.Ile241Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1838 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ile282Thr Rv0565c_p.Ile282Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1848 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 887 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ile309Thr Rv0565c_p.Ile309Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 1 5210 15486 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 1810 2233 False False 5.9447216890595 0.309382652589367 349.949104522224 0 0 0.000707787682982558 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 872 1065 False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 0 0 0.0016992827759538 0.999736147757256 0.998530795728906 0.999993319861894 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ile309Val Rv0565c_p.Ile309Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 3 6 5209 15481 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.99961257829147 0.999156938222445 0.999857810215121 0.333333333333333 0.0748546314196918 0.700704943791459 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1872 2233 False False 1.48598579381839 0.240373448133868 6.9606999827616 0 0 0.000707923512718415 0.99961257829147 0.999156938222445 0.999857810215121 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 3 6 2167 3784 0.00138248847926267 0.000285193152965682 0.0040348522148252 0.998416886543535 0.996557436795264 0.999418810659556 0.333333333333333 0.0748546314196918 0.700704943791459 NA NA NA 0 0 0.4592581264399 NA NA NA NA 898 1065 False False 0 0 0 0 0 0 0 0.873096446700507 0.141128480884732 4.09310723119703 0 0 0.00170084976888778 0.998416886543535 0.996557436795264 0.999418810659556 6 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ile342Thr Rv0565c_p.Ile342Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.2999762698034 0.53686319604546 244.5 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ile358Met Rv0565c_p.Ile358Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1767 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 848 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ile39Thr Rv0565c_p.Ile39Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1775 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 852 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ile46Thr Rv0565c_p.Ile46Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1821 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ile477Val Rv0565c_p.Ile477Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1801 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Leu240Ser Rv0565c_p.Leu240Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 11 5212 15476 0 0 0.000707516179821284 0.999289726867695 0.998729481387772 0.999645382583254 0 0 0.284914152918154 NA NA NA 0 0 0.284914152918154 NA NA NA NA 1789 2233 False False 0 0 1.18361858819336 0 0 0.000707516179821284 0.999289726867695 0.998729481387772 0.999645382583254 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Leu248* Rv0565c_p.Leu248* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 5209 15487 0.000575594781273983 0.000118717215010897 0.00168120176197813 1 0.999761836368682 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1744 2233 False False Inf 1.22809956796298 Inf 0 0 0.000707923512718415 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 836 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 2 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Leu256fs Rv0565c_p.Leu256fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 2 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Leu305Arg Rv0565c_p.Leu305Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1822 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 877 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Leu35Pro Rv0565c_p.Leu35Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1768 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Leu360Arg Rv0565c_p.Leu360Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1966 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 944 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Leu409fs Rv0565c_p.Leu409fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1984 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Leu450fs Rv0565c_p.Leu450fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 5 0 5207 15487 0.000959324635456638 0.000311561141138009 0.0022373118395626 1 0.999761836368682 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 1811 2233 False False Inf 2.72427826476923 Inf 0 0 0.00070819532865061 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 873 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0 0 0.00170006591133688 1 0.999027154404229 1 3 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Lys181_Lys182dup Rv0565c_p.Lys181_Lys182dup 2 inframe_insertion (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1916 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 923 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Lys181Glu Rv0565c_p.Lys181Glu 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 2 5211 15485 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1839 2233 False False 1.48579927077336 0.0251793916671698 28.5526337681963 0 0 0.000707651905360176 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Lys221Thr Rv0565c_p.Lys221Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1931 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Lys236Asn Rv0565c_p.Lys236Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 3 5211 15484 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999806289145735 0.999434000080036 0.999960050383188 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1985 2233 False False 0.990468879933474 0.0188633706776044 12.3373543450537 0 0 0.000707651905360176 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 3 2169 3787 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999208443271767 0.997688494809834 0.999836732216022 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 954 1065 False False 0 0 0 0 0 0 0 0.581988627631781 0.0110856993615618 7.25404417491437 0 0 0.0016992827759538 0.999208443271767 0.997688494809834 0.999836732216022 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Lys259Glu Rv0565c_p.Lys259Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 3 5211 15484 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999806289145735 0.999434000080036 0.999960050383188 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1962 2233 False False 0.990468879933474 0.0188633706776044 12.3373543450537 0 0 0.000707651905360176 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 941 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Lys265Arg Rv0565c_p.Lys265Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1758 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 843 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Lys408_Leu410del Rv0565c_p.Lys408_Leu410del 2 inframe_deletion (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1770 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 849 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0 0 0.00170006591133688 1 0.999027154404229 1 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Lys408* Rv0565c_p.Lys408* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1769 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Lys456Arg Rv0565c_p.Lys456Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1910 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Lys456Asn Rv0565c_p.Lys456Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1752 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Met208Val Rv0565c_p.Met208Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1782 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 854 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Met244Ile Rv0565c_p.Met244Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Met377Arg Rv0565c_p.Met377Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1745 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 837 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Met377Ile Rv0565c_p.Met377Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 4 5210 15483 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.99974171886098 0.999338830952079 0.999929622742193 0.333333333333333 0.0432718682927417 0.777221904496487 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1853 2233 False False 1.48589251439539 0.134348817103157 10.3711983427491 0 0 0.000707787682982558 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 2 2169 3788 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999472295514512 0.998095063429584 0.999936086148442 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 890 1065 False False 0 0 0 0 0 0 0 0.87321346242508 0.0147995228023146 16.7833115850342 0 0 0.0016992827759538 0.999472295514512 0.998095063429584 0.999936086148442 14 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Met377Thr Rv0565c_p.Met377Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1840 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 883 1065 False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 0 0 0.0016992827759538 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Met401Thr Rv0565c_p.Met401Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 5 2 5207 15485 0.000959324635456638 0.000311561141138009 0.0022373118395626 0.99987085943049 0.99953357854254 0.999984360095269 0.714285714285714 0.290420863737342 0.963307433823914 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1849 2233 False False 7.43470328404071 1.21658157410694 78.0025413709288 0 0 0.00070819532865061 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 888 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0 0 0.00170006591133688 1 0.999027154404229 1 5 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Met413Thr Rv0565c_p.Met413Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1823 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Met93Ile Rv0565c_p.Met93Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 15 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Met93Leu Rv0565c_p.Met93Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1888 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 909 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Phe141Leu Rv0565c_p.Phe141Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1783 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Phe225Val Rv0565c_p.Phe225Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Phe263Ser Rv0565c_p.Phe263Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1784 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 855 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Phe483Ser Rv0565c_p.Phe483Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1906 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Phe53Val Rv0565c_p.Phe53Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1995 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 958 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 7 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Phe65Leu Rv0565c_p.Phe65Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 5 0 5207 15487 0.000959324635456638 0.000311561141138009 0.0022373118395626 1 0.999761836368682 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 1790 2233 False False Inf 2.72427826476923 Inf 0 0 0.00070819532865061 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 2166 3790 0.00184331797235023 0.00050246332413509 0.00471284227984187 1 0.999027154404229 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 859 1065 False False 0 0 0 0 0 0 0 Inf 1.15374841388447 Inf 0 0 0.00170163434960586 1 0.999027154404229 1 2 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Pro169Arg Rv0565c_p.Pro169Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 8 5212 15479 0 0 0.000707516179821284 0.99948343772196 0.998982421476308 0.999776959534822 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1953 2233 False False 0 0 1.74050626415467 0 0 0.000707516179821284 0.99948343772196 0.998982421476308 0.999776959534822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 937 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 21 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Pro169fs Rv0565c_p.Pro169fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1949 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 934 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0 0 0.00170006591133688 1 0.999027154404229 1 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Pro169His Rv0565c_p.Pro169His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1881 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Pro213Leu Rv0565c_p.Pro213Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1882 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Pro234Ala Rv0565c_p.Pro234Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1967 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Pro234His Rv0565c_p.Pro234His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1854 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Pro234Leu Rv0565c_p.Pro234Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1855 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 891 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Pro235Thr Rv0565c_p.Pro235Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Pro261Gln Rv0565c_p.Pro261Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1746 2233 False False 0 0 7.19247409791798 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Pro261Leu Rv0565c_p.Pro261Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1889 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Pro288Arg Rv0565c_p.Pro288Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1841 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Pro288Ser Rv0565c_p.Pro288Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1824 2233 False False 0 0 7.19247409791798 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 10 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Pro367fs Rv0565c_p.Pro367fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Pro423dup Rv0565c_p.Pro423dup 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1865 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Pro447fs Rv0565c_p.Pro447fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1935 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Pro451Thr Rv0565c_p.Pro451Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1917 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Pro56Leu Rv0565c_p.Pro56Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1802 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 866 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Pro5Ser Rv0565c_p.Pro5Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1829 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Pro73Leu Rv0565c_p.Pro73Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1791 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ser107Ile Rv0565c_p.Ser107Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1830 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ser116fs Rv0565c_p.Ser116fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1932 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ser117Pro Rv0565c_p.Ser117Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1812 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ser136Asn Rv0565c_p.Ser136Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1873 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 899 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ser20Pro Rv0565c_p.Ser20Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1996 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ser212Pro Rv0565c_p.Ser212Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1747 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 838 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 3 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ser220Pro Rv0565c_p.Ser220Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1897 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ser223Arg Rv0565c_p.Ser223Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ser238Phe Rv0565c_p.Ser238Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ser257Cys Rv0565c_p.Ser257Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1776 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ser257Pro Rv0565c_p.Ser257Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0762045661509476 Inf 0.251763455406319 213.5 2233 False False Inf 0.55810577429468 Inf 0.000191901746305891 4.8585197621771e-06 0.00106873920290263 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0448036218670314 Inf 0.363987246182245 113 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0.000461041954817888 1.16725035605811e-05 0.00256605588112533 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ser435Ala Rv0565c_p.Ser435Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1856 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ser453Ala Rv0565c_p.Ser453Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 18 0 18 0 18 5212 15469 0 0 0.000707516179821284 0.99883773487441 0.99816373964141 0.99931102714521 0 0 0.185301968137852 0 0 0.185301968137852 0 0 0.185301968137852 0 0 0.675373895439417 0.011095223442486 64 2233 False False 0 0 0.675373895439417 0 0 0.000707516179821284 0.99883773487441 0.99816373964141 0.99931102714521 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 32 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ser453Cys Rv0565c_p.Ser453Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1890 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ser63Arg Rv0565c_p.Ser63Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1918 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ser68Pro Rv0565c_p.Ser68Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1421 25 1396 469 1831 4743 13656 0.0899846508058326 0.0823511107777131 0.098080849750239 0.881771808613676 0.876582546901621 0.886817189736735 0.20391304347826 0.187614962835858 0.220968797527901 0.0175932441942294 0.0114169561569522 0.025862157889157 0.0134698275862068 0.00873542003100857 0.0198202842453094 0.051561432411027 0.0331777009438798 0.076558130223484 1.098392344997e-135 4 2233 True False 0.737487870538007 0.661421988132046 0.821125371269126 0.00524328859060402 0.0033959683020919 0.0077304614305359 0.881771808613676 0.876582546901621 0.886817189736735 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 212 5 207 105 272 2065 3518 0.0483870967741935 0.0397436649951446 0.0582745810727782 0.928232189973614 0.919548156039542 0.936248615281715 0.278514588859416 0.233833503414278 0.326712862587929 0.0235849056603773 0.00770130215482492 0.0541781358068919 0.0180505415162454 0.00588629355193364 0.0416189067339759 0.0411505304651951 0.0131945735213021 0.0978706237977296 1.04348733362232e-33 4 1065 True False 0 0 0 0 0 0 0 0.657652043868394 0.516539604905452 0.8325072373579 0.00241545893719806 0.000784743606690268 0.00562780085012259 0.928232189973614 0.919548156039542 0.936248615281715 4432 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Ter487Trpext*? Rv0565c_p.Ter487Trpext*? 2 stop_lost (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1792 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Thr118Ile Rv0565c_p.Thr118Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1825 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Thr179fs Rv0565c_p.Thr179fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1803 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 867 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Thr179Ile Rv0565c_p.Thr179Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1936 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Thr191Ala Rv0565c_p.Thr191Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1866 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 895 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Thr194Ile Rv0565c_p.Thr194Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1813 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Thr237Ile Rv0565c_p.Thr237Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 7 5210 15480 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999548008006715 0.999068946905294 0.99981825708278 0.222222222222222 0.0281449734778982 0.600093573716312 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1874 2233 False False 0.848916918014806 0.0860206666092397 4.46043370684753 0 0 0.000707787682982558 0.999548008006715 0.999068946905294 0.99981825708278 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 900 1065 False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 0 0 0.0016992827759538 0.999736147757256 0.998530795728906 0.999993319861894 41 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Thr271fs Rv0565c_p.Thr271fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1898 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 914 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Thr310Pro Rv0565c_p.Thr310Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 3 1 5209 15486 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.999935429715245 0.999640290494779 0.999998365223265 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 1753 2233 False False 8.91879439431752 0.715852821346612 466.959465949029 0 0 0.000707923512718415 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 2167 3790 0.00138248847926267 0.000285193152965682 0.0040348522148252 1 0.999027154404229 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 839 1065 False False 0 0 0 0 0 0 0 Inf 0.721991535026265 Inf 0 0 0.00170084976888778 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Thr318Ala Rv0565c_p.Thr318Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1963 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Thr318fs Rv0565c_p.Thr318fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1857 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Thr318Ile Rv0565c_p.Thr318Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 5209 15487 0.000575594781273983 0.000118717215010897 0.00168120176197813 1 0.999761836368682 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1831 2233 False False Inf 1.22809956796298 Inf 0 0 0.000707923512718415 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 2167 3790 0.00138248847926267 0.000285193152965682 0.0040348522148252 1 0.999027154404229 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 878 1065 False False 0 0 0 0 0 0 0 Inf 0.721991535026265 Inf 0 0 0.00170084976888778 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Thr344Ile Rv0565c_p.Thr344Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1867 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Thr402fs Rv0565c_p.Thr402fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 114 202 5098 15285 0.0218726016884113 0.0180752492924057 0.026217604349631 0.986956802479498 0.985043206921475 0.98868408623299 0.360759493670886 0.307756293858192 0.41640057641171 NA NA NA 0 0 0.0180960435918408 NA NA NA NA 1771 2233 False False 1.69207299309766 1.32988710149613 2.14418017024703 0 0 0.000723331728411566 0.986956802479498 0.985043206921475 0.98868408623299 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 44 59 2126 3731 0.0202764976958525 0.0147706389390353 0.0271255042626715 0.9844327176781 0.979964758028303 0.988128897440186 0.427184466019417 0.330183625101986 0.528483127388902 NA NA NA 0 0 0.0606089009503398 NA NA NA NA 850 1065 False False 0 0 0 0 0 0 0 1.30876795765103 0.861728534684861 1.97466353637643 0 0 0.00173362228015659 0.9844327176781 0.979964758028303 0.988128897440186 878 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Thr402Met Rv0565c_p.Thr402Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1997 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 959 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0 0 0.00170006591133688 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Thr406Lys Rv0565c_p.Thr406Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1971 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Thr49Ala Rv0565c_p.Thr49Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1968 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 945 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Thr66Ala Rv0565c_p.Thr66Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1899 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 915 1065 False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 0 0 0.0016992827759538 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Thr91Ala Rv0565c_p.Thr91Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1759 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 844 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Trp114* Rv0565c_p.Trp114* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1754 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 840 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Trp121* Rv0565c_p.Trp121* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1954 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Trp172Arg Rv0565c_p.Trp172Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1978 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Trp172* Rv0565c_p.Trp172* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1755 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 841 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Trp254Arg Rv0565c_p.Trp254Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1814 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 874 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Trp254Gly Rv0565c_p.Trp254Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 3 5210 15484 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999806289145735 0.999434000080036 0.999960050383188 0.4 0.0527449505263169 0.853367200365326 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1979 2233 False False 1.98131797824696 0.165426255296508 17.2953159846476 0 0 0.000707787682982558 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 950 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0 0 0.00170006591133688 1 0.999027154404229 1 3 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Trp266* Rv0565c_p.Trp266* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1891 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Trp293Arg Rv0565c_p.Trp293Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1804 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Trp386Gly Rv0565c_p.Trp386Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 875 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Trp395Arg Rv0565c_p.Trp395Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1919 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Trp395* Rv0565c_p.Trp395* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1793 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 860 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Trp436Cys Rv0565c_p.Trp436Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 3 1 5209 15486 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.999935429715245 0.999640290494779 0.999998365223265 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 1937 2233 False False 8.91879439431752 0.715852821346612 466.959465949029 0 0 0.000707923512718415 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 1 2168 3789 0.000921658986175115 0.000111636674590768 0.0033253435449308 0.999736147757256 0.998530795728906 0.999993319861894 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 929 1065 False False 0 0 0 0 0 0 0 3.49538745387453 0.181825522231654 206.012215468794 0 0 0.00170006591133688 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.TrpLeu266* Rv0565c_p.TrpLeu266* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1858 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Tyr134Asp Rv0565c_p.Tyr134Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1972 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 947 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Tyr145Cys Rv0565c_p.Tyr145Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1955 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Tyr146Cys Rv0565c_p.Tyr146Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1973 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 948 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Tyr146dup Rv0565c_p.Tyr146dup 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 0 0 0 10 1 5202 15486 0.00191864927091327 0.000920438305261622 0.00352562450313611 0.999935429715245 0.999640290494779 0.999998365223265 0.909090909090909 0.587220083011617 0.997701027786185 NA NA NA 0 0 0.975 NA NA NA NA 1760 2233 False False 29.7693194925028 4.23282211885722 1283.5342976727 0 0 0.00070887578257034 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 845 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 3 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Tyr146His Rv0565c_p.Tyr146His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1907 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Tyr146* Rv0565c_p.Tyr146* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1980 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 951 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Tyr152Asp Rv0565c_p.Tyr152Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1832 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 879 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Tyr245Asp Rv0565c_p.Tyr245Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1956 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Tyr26Cys Rv0565c_p.Tyr26Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1805 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Tyr26* Rv0565c_p.Tyr26* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1964 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 942 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Tyr306Asp Rv0565c_p.Tyr306Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1950 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 935 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Tyr306His Rv0565c_p.Tyr306His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1833 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 880 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Tyr373Cys Rv0565c_p.Tyr373Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1842 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 884 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0 0 0.00170006591133688 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Tyr373fs Rv0565c_p.Tyr373fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1974 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Tyr390His Rv0565c_p.Tyr390His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1920 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 924 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Tyr465Cys Rv0565c_p.Tyr465Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1986 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 955 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Tyr465Ser Rv0565c_p.Tyr465Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1806 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 868 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Tyr55His Rv0565c_p.Tyr55His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1921 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Tyr71fs Rv0565c_p.Tyr71fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Tyr71His Rv0565c_p.Tyr71His 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 5211 15485 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8263323782973 1 815 2233 False False 1.48579927077336 0.0251793916671698 28.5526337681963 0 0 0.000707651905360176 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Tyr89Asp Rv0565c_p.Tyr89Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1875 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 901 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Tyr89* Rv0565c_p.Tyr89* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1843 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Tyr97Asp Rv0565c_p.Tyr97Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 5 5210 15482 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999677148576225 0.999246734667469 0.999895162977301 0.285714285714285 0.0366925661760855 0.709579136262657 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1816 2233 False False 1.18863723608445 0.113129903278746 7.26455938498844 0 0 0.000707787682982558 0.999677148576225 0.999246734667469 0.999895162977301 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Val109Ile Rv0565c_p.Val109Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 1 5210 15486 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 1911 2233 False False 5.9447216890595 0.309382652589367 349.949104522224 0 0 0.000707787682982558 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 1 2168 3789 0.000921658986175115 0.000111636674590768 0.0033253435449308 0.999736147757256 0.998530795728906 0.999993319861894 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 921 1065 False False 0 0 0 0 0 0 0 3.49538745387453 0.181825522231654 206.012215468794 0 0 0.00170006591133688 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Val123fs Rv0565c_p.Val123fs 2 frameshift (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 7.19247409791798 0.577090863007554 439 2233 False False 0 0 7.19247409791798 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Val130Met Rv0565c_p.Val130Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 7.19247409791798 0.577090863007554 439 2233 False False 0 0 7.19247409791798 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Val139Ala Rv0565c_p.Val139Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1965 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 943 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Val15Phe Rv0565c_p.Val15Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1938 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Val166Ala Rv0565c_p.Val166Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Val166fs Rv0565c_p.Val166fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Val184Ala Rv0565c_p.Val184Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1761 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 846 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Val184Met Rv0565c_p.Val184Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1859 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Val185Ala Rv0565c_p.Val185Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 5 2 5207 15485 0.000959324635456638 0.000311561141138009 0.0022373118395626 0.99987085943049 0.99953357854254 0.999984360095269 0.714285714285714 0.290420863737342 0.963307433823914 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1876 2233 False False 7.43470328404071 1.21658157410694 78.0025413709288 0 0 0.00070819532865061 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 5 2 2165 3788 0.00230414746543778 0.000748560476988087 0.00536885389822181 0.999472295514512 0.998095063429584 0.999936086148442 0.714285714285714 0.290420863737342 0.963307433823914 NA NA NA 0 0 0.841886116991581 NA NA NA NA 902 1065 False False 0 0 0 0 0 0 0 4.37413394919168 0.715190220301017 45.9579406529699 0 0 0.00170241965449235 0.999472295514512 0.998095063429584 0.999936086148442 3 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Val185Met Rv0565c_p.Val185Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1957 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Val193Ala Rv0565c_p.Val193Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Val229Ala Rv0565c_p.Val229Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Val242Phe Rv0565c_p.Val242Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1922 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Val252Ala Rv0565c_p.Val252Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1834 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 881 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Val317Ala Rv0565c_p.Val317Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1933 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Val317Leu Rv0565c_p.Val317Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1975 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Val343Gly Rv0565c_p.Val343Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1762 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Val343Ile Rv0565c_p.Val343Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1748 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Val343Leu Rv0565c_p.Val343Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Val343Phe Rv0565c_p.Val343Phe 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 2 5211 15485 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1794 2233 False False 1.48579927077336 0.0251793916671698 28.5526337681963 0 0 0.000707651905360176 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Val381Gly Rv0565c_p.Val381Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1987 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Val388Ala Rv0565c_p.Val388Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1835 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 882 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Val443Gly Rv0565c_p.Val443Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1807 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 869 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv0565c p.Val461Leu Rv0565c_p.Val461Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1988 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 c.1005G>A Rv3083_c.1005G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.1035G>A Rv3083_c.1035G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0761899451219867 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.103C>T Rv3083_c.103C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.1059G>A Rv3083_c.1059G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.19247409791798 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.105G>A Rv3083_c.105G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 55 394 5157 15093 0.010552570990023 0.00795925820989337 0.0137137286918515 0.974559307806547 0.971956184207496 0.976982029102494 0.122494432071269 0.0936274525993625 0.156443559613656 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.408549711643234 0.301783464023626 0.543869875527512 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 12 30 2158 3760 0.00552995391705069 0.00286057468269438 0.00963977234551449 0.992084432717678 0.988719171683225 0.994653211093733 0.285714285714285 0.157191466765745 0.445838803307969 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.696941612604263 0.324270435844024 1.40535689078473 NA NA NA NA NA NA 918 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.108A>G Rv3083_c.108A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.1110G>A Rv3083_c.1110G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.97179044329303 0.0378514560716107 232.854636669753 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.1132C>T Rv3083_c.1132C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0761899451219867 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.1155C>T Rv3083_c.1155C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.1173C>T Rv3083_c.1173C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.1189C>T Rv3083_c.1189C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.1206C>G Rv3083_c.1206C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 5 15 5207 15472 0.000959324635456638 0.000311561141138009 0.0022373118395626 0.999031445728675 0.998403019382043 0.999457809400789 0.25 0.0865714691014345 0.491045871707957 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.990461558158888 0.281474837317295 2.86868358642959 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 34 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.1209C>T Rv3083_c.1209C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.1215C>T Rv3083_c.1215C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 11 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.1224G>A Rv3083_c.1224G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0761899451219867 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.1230G>A Rv3083_c.1230G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.1257G>A Rv3083_c.1257G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.1260G>A Rv3083_c.1260G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0761899451219867 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.126C>T Rv3083_c.126C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.97179044329303 0.0378514560716107 232.854636669753 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.1278G>A Rv3083_c.1278G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 5212 15483 0 0 0.000707516179821284 0.99974171886098 0.999338830952079 0.999929622742193 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.5014696306354 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 23 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.1284C>T Rv3083_c.1284C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 10 5210 15477 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.99935429715245 0.998812851129914 0.999690318343011 0.166666666666666 0.0208625254600923 0.484137748685967 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.594126679462572 0.0632761509769629 2.78931533709089 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 NA NA NA NA NA NA 144 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.1329T>C Rv3083_c.1329T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.1362G>A Rv3083_c.1362G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.55810577429468 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.1365C>A Rv3083_c.1365C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.1374T>C Rv3083_c.1374T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.1377G>A Rv3083_c.1377G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.1419G>A Rv3083_c.1419G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.1431C>G Rv3083_c.1431C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.1461A>C Rv3083_c.1461A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0761899451219867 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.153G>T Rv3083_c.153G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.15C>T Rv3083_c.15C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.165G>A Rv3083_c.165G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.168C>T Rv3083_c.168C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 7 5212 15480 0 0 0.000707516179821284 0.999548008006715 0.999068946905294 0.99981825708278 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.06147084147984 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.-16C>A Rv3083_c.-16C>A 2 upstream_gene_variant 3448488 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1636 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 c.-16C>G Rv3083_c.-16C>G 2 upstream_gene_variant 3448488 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1581 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 c.-16C>T Rv3083_c.-16C>T 2 upstream_gene_variant 3448488 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1613 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 c.-17T>G Rv3083_c.-17T>G 2 upstream_gene_variant 3448487 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1709 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 821 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 8 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 c.-18C>G Rv3083_c.-18C>G 2 upstream_gene_variant 3448486 1 2 0 2 1 2 5211 15485 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8263323782973 1 815 2233 False False 1.48579927077336 0.0251793916671698 28.5526337681963 0 0 0.000707651905360176 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 68.0751891811639 1 405 1065 False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 0 0 0.0016992827759538 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 c.195G>A Rv3083_c.195G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.204G>A Rv3083_c.204G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.-20T>C Rv3083_c.-20T>C 2 upstream_gene_variant 3448484 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1659 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 805 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 7 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 c.234C>T Rv3083_c.234C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.-23G>C Rv3083_c.-23G>C 2 upstream_gene_variant 3448481 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1605 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 785 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 7 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 c.246G>A Rv3083_c.246G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.252C>T Rv3083_c.252C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.-25delG Rv3083_c.-25delG 2 upstream_gene_variant 3448478 1 1 0 1 0 4 5212 15483 0 0 0.000707516179821284 0.99974171886098 0.999338830952079 0.999929622742193 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 115.655055287022 1 815 2233 False False 0 0 4.5014696306354 0 0 0.000707516179821284 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 20 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 c.264C>A Rv3083_c.264C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.264C>T Rv3083_c.264C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.-26C>T Rv3083_c.-26C>T 2 upstream_gene_variant 3448478 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1516 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 c.-29T>C Rv3083_c.-29T>C 2 upstream_gene_variant 3448475 NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1691 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 816 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 c.-30G>A Rv3083_c.-30G>A 2 upstream_gene_variant 3448474 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1521 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 c.-30G>T Rv3083_c.-30G>T 2 upstream_gene_variant 3448474 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1590 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 778 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 7 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 c.312C>T Rv3083_c.312C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0761899451219867 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.-32A>T Rv3083_c.-32A>T 2 upstream_gene_variant 3448472 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1651 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 c.33C>T Rv3083_c.33C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.378C>T Rv3083_c.378C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0761899451219867 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.-38G>A Rv3083_c.-38G>A 2 upstream_gene_variant 3448466 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1637 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 c.390C>G Rv3083_c.390C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.39C>T Rv3083_c.39C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.3G>A Rv3083_c.3G>A 2 initiator_codon_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0761899451219867 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.402T>C Rv3083_c.402T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.40C>T Rv3083_c.40C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.-41A>C Rv3083_c.-41A>C 2 upstream_gene_variant 3448463 1 1 0 1 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 115.669966941234 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 c.420C>T Rv3083_c.420C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 7 5212 15480 0 0 0.000707516179821284 0.999548008006715 0.999068946905294 0.99981825708278 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.06147084147984 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.42A>G Rv3083_c.42A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.-43delA Rv3083_c.-43delA 2 upstream_gene_variant 3448460 NA 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1724 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 c.462C>T Rv3083_c.462C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.465C>A Rv3083_c.465C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0761899451219867 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.486G>A Rv3083_c.486G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.-48G>A Rv3083_c.-48G>A 2 upstream_gene_variant 3448456 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.2999762698034 0.53686319604546 244.5 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 10 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 c.-4A>C Rv3083_c.-4A>C 2 upstream_gene_variant 3448500 1 0 0 0 4 1 5208 15486 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.999935429715245 0.999640290494779 0.999998365223265 0.8 0.28358206388191 0.994949236620532 NA NA NA 0 0 0.975 NA NA NA NA 1591 2233 False False 11.8940092165898 1.17652678598182 583.885453446482 0 0 0.000708059394597755 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 779 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 2 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 c.510C>G Rv3083_c.510C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0761899451219867 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.-51G>T Rv3083_c.-51G>T 2 upstream_gene_variant 3448453 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1699 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 817 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 7 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 c.528C>T Rv3083_c.528C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.567G>A Rv3083_c.567G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.57G>A Rv3083_c.57G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.603C>G Rv3083_c.603C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.642G>A Rv3083_c.642G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 13 5210 15474 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999160586298185 0.998565004766387 0.999552974256682 0.133333333333333 0.0165759134400836 0.404602696603372 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.456931935626753 0.0500493304513424 2.01928071228607 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 3 2169 3787 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999208443271767 0.997688494809834 0.999836732216022 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.581988627631781 0.0110856993615618 7.25404417491437 NA NA NA NA NA NA 18 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.648C>T Rv3083_c.648C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.759G>A Rv3083_c.759G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.798G>A Rv3083_c.798G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.-7T>C Rv3083_c.-7T>C 2 upstream_gene_variant 3448497 NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1624 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 792 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 c.828C>T Rv3083_c.828C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.834C>G Rv3083_c.834C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.864G>A Rv3083_c.864G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.876G>A Rv3083_c.876G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.897C>G Rv3083_c.897C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.906C>T Rv3083_c.906C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.909C>A Rv3083_c.909C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.913C>T Rv3083_c.913C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.939G>C Rv3083_c.939G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 15.8232972540303 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 68.0438514794824 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.942G>C Rv3083_c.942G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 115.677422765729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Ethionamide Rv3083 c.-9G>A Rv3083_c.-9G>A 2 upstream_gene_variant 3448495 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1564 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 767 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 c.-9G>C Rv3083_c.-9G>C 2 upstream_gene_variant 3448495 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1660 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 806 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 7 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 deletion Rv3083_deletion 2 feature_ablation (see "Genomic_coordinates" sheet) NA 0 0 0 15 46 5197 15441 0.00287797390636991 0.0016116471700824 0.00474234467149281 0.997029766901272 0.996040090412323 0.997824620361947 0.245901639344262 0.144642721236473 0.372940703498143 NA NA NA 0 0 0.0770618270519006 NA NA NA NA 1642 2233 False False 0.968849085174557 0.501993473030191 1.76878379317138 0 0 0.000709557545345995 0.997029766901272 0.996040090412323 0.997824620361947 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 8 22 2162 3768 0.00368663594470046 0.00159293019145598 0.00725115327762171 0.99419525065963 0.991224655744321 0.996358725497634 0.266666666666666 0.122794809872354 0.458893651394751 NA NA NA 0 0 0.154372512815574 NA NA NA NA 799 1065 False False 0 0 0 0 0 0 0 0.63375662265579 0.243529202375433 1.48128540616426 0 0 0.00170477992420233 0.99419525065963 0.991224655744321 0.996358725497634 278 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 LoF Rv3083_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 11 1 10 101 110 5111 15377 0.019378357636224 0.0158110088250247 0.0234972251890361 0.992897268676954 0.991445536408655 0.994158906609394 0.47867298578199 0.409620886011654 0.548332692281032 0.0909090909090909 0.00229897221381426 0.412779916988382 0.009009009009009 0.000228062350046371 0.0491734186115297 0.30086088828018 0.00693497237523313 2.11587049379559 0.311880440230993 347 2233 False False 2.76244997420892 2.08327215938054 3.65918239984409 0.000195618153364632 4.95261058091085e-06 0.00108942736287125 0.992897268676954 0.991445536408655 0.994158906609394 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 30 29 2140 3761 0.0138248847926267 0.00934651064082103 0.0196774763320224 0.992348284960422 0.989029211445503 0.994869711027449 0.508474576271186 0.374982549734976 0.641087272199467 NA NA NA 0 0 0.119444869069502 NA NA NA NA 1064 1065 False False 0 0 0 0 0 0 0 1.81807927811795 1.0511405954545 3.14858649436597 0 0 0.00172229059825759 0.992348284960422 0.989029211445503 0.994869711027449 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Ala119Val Rv3083_p.Ala119Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Ala12_Gly13del Rv3083_p.Ala12_Gly13del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1551 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 760 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Ala189fs Rv3083_p.Ala189fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 115.669966941234 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Ala197Val Rv3083_p.Ala197Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1606 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Ala205Pro Rv3083_p.Ala205Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1614 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Ala205Thr Rv3083_p.Ala205Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 12 5212 15475 0 0 0.000707516179821284 0.99922515658294 0.998646896080726 0.999599565042795 0 0 0.264648469397051 NA NA NA 0 0 0.264648469397051 NA NA NA NA 1735 2233 False False 0 0 1.06903209420596 0 0 0.000707516179821284 0.99922515658294 0.998646896080726 0.999599565042795 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 2170 3787 0 0 0.00169850036174098 0.999208443271767 0.997688494809834 0.999836732216022 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 831 1065 False False 0 0 0 0 0 0 0 0 0 4.22663965322398 0 0 0.00169850036174098 0.999208443271767 0.997688494809834 0.999836732216022 10 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Ala20fs Rv3083_p.Ala20fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1725 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Ala222Thr Rv3083_p.Ala222Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Ala257Ser Rv3083_p.Ala257Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Ala313fs Rv3083_p.Ala313fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 32 23 5180 15464 0.00613967766692248 0.00420321397869361 0.00865643184162767 0.998514883450636 0.997772424247496 0.999058337853371 0.581818181818181 0.441058410576993 0.713454754751 1 0.025 1 0.0416666666666666 0.00105435244546974 0.211201683456973 Inf 0.0765319931919925 Inf 0.250956648098813 193 2233 False False 4.15350008393486 2.35312653766457 7.43966458192307 0.000193012931866435 4.88665240775446e-06 0.00107492488740452 0.998514883450636 0.997772424247496 0.999058337853371 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 811 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0 0 0.00170006591133688 1 0.999027154404229 1 5 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Ala313Ser Rv3083_p.Ala313Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Ala345Ser Rv3083_p.Ala345Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Ala363Thr Rv3083_p.Ala363Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 115.669966941234 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Ala381Thr Rv3083_p.Ala381Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 5212 15483 0 0 0.000707516179821284 0.99974171886098 0.999338830952079 0.999929622742193 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1552 2233 False False 0 0 4.5014696306354 0 0 0.000707516179821284 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 39 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Ala385fs Rv3083_p.Ala385fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1565 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Ala404Thr Rv3083_p.Ala404Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1692 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Ala414fs Rv3083_p.Ala414fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Ala414Thr Rv3083_p.Ala414Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1541 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Ala470Pro Rv3083_p.Ala470Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Ala486Gly Rv3083_p.Ala486Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 1 5210 15486 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 1575 2233 False False 5.9447216890595 0.309382652589367 349.949104522224 0 0 0.000707787682982558 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Ala487Thr Rv3083_p.Ala487Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1607 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Ala488Val Rv3083_p.Ala488Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1675 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Ala489Val Rv3083_p.Ala489Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1726 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 826 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Ala86Pro Rv3083_p.Ala86Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Ala86Val Rv3083_p.Ala86Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1608 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 786 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Arg112Leu Rv3083_p.Arg112Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1542 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Arg112Pro Rv3083_p.Arg112Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1599 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Arg129Gln Rv3083_p.Arg129Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1615 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Arg158_His165del Rv3083_p.Arg158_His165del 2 inframe_deletion (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1727 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Arg246Cys Rv3083_p.Arg246Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1553 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Arg252Gln Rv3083_p.Arg252Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.2999762698034 0.53686319604546 244.5 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 2 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Arg274Gln Rv3083_p.Arg274Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 11 5212 15476 0 0 0.000707516179821284 0.999289726867695 0.998729481387772 0.999645382583254 0 0 0.284914152918154 NA NA NA 0 0 0.284914152918154 NA NA NA NA 1576 2233 False False 0 0 1.18361858819336 0 0 0.000707516179821284 0.999289726867695 0.998729481387772 0.999645382583254 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 10 2170 3780 0 0 0.00169850036174098 0.997361477572559 0.995153033699313 0.99873402334933 0 0 0.30849710781876 NA NA NA 0 0 0.30849710781876 NA NA NA NA 771 1065 False False 0 0 0 0 0 0 0 0 0 0.778110309621997 0 0 0.00169850036174098 0.997361477572559 0.995153033699313 0.99873402334933 2 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Arg275Cys Rv3083_p.Arg275Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 115.699581334225 1 815 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Arg279fs Rv3083_p.Arg279fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1554 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 761 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Arg335Trp Rv3083_p.Arg335Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1530 2233 False False 0 0 7.19247409791798 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 750 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 4 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Arg37Gly Rv3083_p.Arg37Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1684 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Arg408Gln Rv3083_p.Arg408Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1667 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Arg40fs Rv3083_p.Arg40fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 115.669966941234 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Arg424Cys Rv3083_p.Arg424Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Arg446His Rv3083_p.Arg446His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 115.669966941234 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Arg446Pro Rv3083_p.Arg446Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0761899451219867 Inf 0.251799603845596 276 2233 False False Inf 0.0761899451219867 Inf 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Arg461Lys Rv3083_p.Arg461Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1676 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 812 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 7 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Arg49Cys Rv3083_p.Arg49Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 5209 15487 0.000575594781273983 0.000118717215010897 0.00168120176197813 1 0.999761836368682 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1710 2233 False False Inf 1.22809956796298 Inf 0 0 0.000707923512718415 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Arg67Ser Rv3083_p.Arg67Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1717 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Asn285fs Rv3083_p.Asn285fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1543 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 2169 3789 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999736147757256 0.998530795728906 0.999993319861894 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 754 1065 False False 0 0 0 0 0 0 0 1.74688796680497 0.0222439624669857 137.016358245527 0 0 0.0016992827759538 0.999736147757256 0.998530795728906 0.999993319861894 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Asn349Lys Rv3083_p.Asn349Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1522 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Asn349Ser Rv3083_p.Asn349Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1531 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Asn380Lys Rv3083_p.Asn380Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1577 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Asn380Ser Rv3083_p.Asn380Ser 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 9 38 5203 15449 0.00172678434382194 0.000789890217063144 0.00327543249467561 0.997546329179311 0.996633684945735 0.998263069313119 0.191489361702127 0.0914915680081901 0.332597336833885 NA NA NA 0 0 0.0925127614158782 NA NA NA NA 1532 2233 False False 0.703243068270329 0.298816205295539 1.48100248277074 0 0 0.000708739587198625 0.997546329179311 0.996633684945735 0.998263069313119 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 6 10 2164 3780 0.00276497695852534 0.00101535276242503 0.00600840604626057 0.997361477572559 0.995153033699313 0.99873402334933 0.375 0.151983675081122 0.645653905697921 NA NA NA 0 0 0.30849710781876 NA NA NA NA 751 1065 False False 0 0 0 0 0 0 0 1.04805914972273 0.312626780087712 3.18788933472478 0 0 0.00170320568455034 0.997361477572559 0.995153033699313 0.99873402334933 103 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Asn383Asp Rv3083_p.Asn383Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1517 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Asp146Glu Rv3083_p.Asp146Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Asp224Ala Rv3083_p.Asp224Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Asp236Asn Rv3083_p.Asp236Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Asp282fs Rv3083_p.Asp282fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Asp29Asn Rv3083_p.Asp29Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1638 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 798 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 7 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Asp415Asn Rv3083_p.Asp415Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1600 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 10 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Asp432Asn Rv3083_p.Asp432Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 5 5210 15482 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999677148576225 0.999246734667469 0.999895162977301 0.285714285714285 0.0366925661760855 0.709579136262657 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1592 2233 False False 1.18863723608445 0.113129903278746 7.26455938498844 0 0 0.000707787682982558 0.999677148576225 0.999246734667469 0.999895162977301 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Asp469Ala Rv3083_p.Asp469Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1661 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Asp469Gly Rv3083_p.Asp469Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1677 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Asp46His Rv3083_p.Asp46His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1620 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Asp480fs Rv3083_p.Asp480fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1555 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Asp56Ala Rv3083_p.Asp56Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1631 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Asp58Asn Rv3083_p.Asp58Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1621 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 791 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Asp71His Rv3083_p.Asp71His 2 missense_variant (see "Genomic_coordinates" sheet) 1 455 29 426 304 985 4908 14502 0.0583269378357636 0.0521172481796833 0.065036756054732 0.936398269516368 0.932439801169435 0.940191829661326 0.235841737781225 0.212902252197414 0.259992242860324 0.0637362637362637 0.0430970709394585 0.09025579638962 0.0285996055226824 0.0192354663544478 0.0408169385060114 0.201146159762158 0.132899188680193 0.2936396614871 2.15252238417545e-25 8 2233 True False 0.911928313454879 0.795993230931825 1.04251741847681 0.00587401255823374 0.00393734329743144 0.00842524923460563 0.936398269516368 0.932439801169435 0.940191829661326 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 68 4 64 92 147 2078 3643 0.0423963133640553 0.0343118151563289 0.0517439601376302 0.961213720316622 0.954568676188782 0.967134802484356 0.384937238493723 0.322930058038558 0.44983647835362 0.0588235294117647 0.0162581609893473 0.143817825492001 0.0264900662251655 0.0072638077946498 0.0664342426742488 0.109570500481231 0.0289367865300971 0.295188715580618 1.08847326939853e-08 7 1065 True False 0 0 0 0 0 0 0 1.0971957599209 0.831352238226812 1.44196991225069 0.00192122958693563 0.000523710720134688 0.0049117415425734 0.961213720316622 0.954568676188782 0.967134802484356 3194 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Asp87fs Rv3083_p.Asp87fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1685 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Asp87Glu Rv3083_p.Asp87Glu 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1662 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Cys298Arg Rv3083_p.Cys298Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1544 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Cys298Ser Rv3083_p.Cys298Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Cys331Arg Rv3083_p.Cys331Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1678 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Cys331Gly Rv3083_p.Cys331Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1518 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 745 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Cys407Arg Rv3083_p.Cys407Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 3 7 5209 15480 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.999548008006715 0.999068946905294 0.99981825708278 0.3 0.0667395111777345 0.652452850059997 0 0 0.841886116991581 0 0 0.409616397225003 0 0 15.827297175083 1 815 2233 False False 1.27361983380413 0.212438830534513 5.58065374082854 0 0 0.000707923512718415 0.999548008006715 0.999068946905294 0.99981825708278 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 769 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 5 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Cys407Gly Rv3083_p.Cys407Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Gln167* Rv3083_p.Gln167* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1609 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Gln256Arg Rv3083_p.Gln256Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1643 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Gln351* Rv3083_p.Gln351* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Gln366* Rv3083_p.Gln366* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1644 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 800 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Gln438* Rv3083_p.Gln438* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1646 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Gln448Arg Rv3083_p.Gln448Arg 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1595 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Gln448His Rv3083_p.Gln448His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1700 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Gln448Pro Rv3083_p.Gln448Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1639 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Gln454fs Rv3083_p.Gln454fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 5209 15487 0.000575594781273983 0.000118717215010897 0.00168120176197813 1 0.999761836368682 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1647 2233 False False Inf 1.22809956796298 Inf 0 0 0.000707923512718415 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Gln454Pro Rv3083_p.Gln454Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1578 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Glu123Asp Rv3083_p.Glu123Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1640 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Glu322Asp Rv3083_p.Glu322Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1686 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Glu322Lys Rv3083_p.Glu322Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.2999762698034 0.53686319604546 244.5 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 3 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Glu336Gln Rv3083_p.Glu336Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1533 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Glu338fs Rv3083_p.Glu338fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1728 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Glu36Gly Rv3083_p.Glu36Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1534 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Glu36Lys Rv3083_p.Glu36Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1582 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Glu475Lys Rv3083_p.Glu475Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1566 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 768 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Gly101Asp Rv3083_p.Gly101Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 3 4 5209 15483 0.000575594781273983 0.000118717215010897 0.00168120176197813 0.99974171886098 0.999338830952079 0.999929622742193 0.428571428571428 0.0989882784425078 0.815948432359917 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1579 2233 False False 2.2292666538683 0.326438409930677 13.182222747906 0 0 0.000707923512718415 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 3 3 2167 3787 0.00138248847926267 0.000285193152965682 0.0040348522148252 0.999208443271767 0.997688494809834 0.999836732216022 0.5 0.118117248757025 0.881882751242974 NA NA NA 0 0 0.707598226178713 NA NA NA NA 772 1065 False False 0 0 0 0 0 0 0 1.74757729580064 0.233837130446773 13.0617462404894 0 0 0.00170084976888778 0.999208443271767 0.997688494809834 0.999836732216022 4 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Gly101Ser Rv3083_p.Gly101Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1523 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Gly11Cys Rv3083_p.Gly11Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 5209 15487 0.000575594781273983 0.000118717215010897 0.00168120176197813 1 0.999761836368682 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1625 2233 False False Inf 1.22809956796298 Inf 0 0 0.000707923512718415 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 2167 3790 0.00138248847926267 0.000285193152965682 0.0040348522148252 1 0.999027154404229 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 793 1065 False False 0 0 0 0 0 0 0 Inf 0.721991535026265 Inf 0 0 0.00170084976888778 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Gly120Ser Rv3083_p.Gly120Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1687 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Gly141Cys Rv3083_p.Gly141Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Gly141Ser Rv3083_p.Gly141Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1701 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Gly155Ser Rv3083_p.Gly155Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1671 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 810 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 2 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Gly184Ser Rv3083_p.Gly184Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1702 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Gly186Asp Rv3083_p.Gly186Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1601 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Gly18Glu Rv3083_p.Gly18Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1648 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 802 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Gly198Cys Rv3083_p.Gly198Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1545 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 755 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0 0 0.00170006591133688 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Gly202Asp Rv3083_p.Gly202Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1641 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Gly328Asp Rv3083_p.Gly328Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 5209 15487 0.000575594781273983 0.000118717215010897 0.00168120176197813 1 0.999761836368682 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1567 2233 False False Inf 1.22809956796298 Inf 0 0 0.000707923512718415 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Gly334Ala Rv3083_p.Gly334Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1610 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 787 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Gly334Ser Rv3083_p.Gly334Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Gly354Ser Rv3083_p.Gly354Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1524 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Gly362Asp Rv3083_p.Gly362Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1672 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Gly375Ser Rv3083_p.Gly375Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1652 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Gly403Asp Rv3083_p.Gly403Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1535 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Gly42Arg Rv3083_p.Gly42Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1596 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Gly442Ser Rv3083_p.Gly442Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1711 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Gly447Arg Rv3083_p.Gly447Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 5212 15482 0 0 0.000707516179821284 0.999677148576225 0.999246734667469 0.999895162977301 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 3.24289311550326 0.33983036876334 352 2233 False False 0 0 3.24289311550326 0 0 0.000707516179821284 0.999677148576225 0.999246734667469 0.999895162977301 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Gly447Asp Rv3083_p.Gly447Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 115.669966941234 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Gly455fs Rv3083_p.Gly455fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 5 0 5207 15487 0.000959324635456638 0.000311561141138009 0.0022373118395626 1 0.999761836368682 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 1546 2233 False False Inf 2.72427826476923 Inf 0 0 0.00070819532865061 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 2166 3790 0.00184331797235023 0.00050246332413509 0.00471284227984187 1 0.999027154404229 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 756 1065 False False 0 0 0 0 0 0 0 Inf 1.15374841388447 Inf 0 0 0.00170163434960586 1 0.999027154404229 1 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Gly481Ala Rv3083_p.Gly481Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Gly481Asp Rv3083_p.Gly481Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 115.669966941234 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 5 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Gly52Arg Rv3083_p.Gly52Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1547 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 757 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Gly63Ala Rv3083_p.Gly63Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1593 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 780 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Gly93Asp Rv3083_p.Gly93Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.His122Gln Rv3083_p.His122Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1703 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 818 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 7 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.His157Asp Rv3083_p.His157Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1556 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 762 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 7 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.His165Gln Rv3083_p.His165Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.His168_Trp169dup Rv3083_p.His168_Trp169dup 2 inframe_insertion (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1548 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 758 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.His168Pro Rv3083_p.His168Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 4 4 5208 15483 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.99974171886098 0.999338830952079 0.999929622742193 0.5 0.157012770487058 0.842987229512941 0 0 0.975 0 0 0.602364635616474 0 0 115.743723408082 1 815 2233 False False 2.9729262672811 0.553517542355507 15.9639231757182 0 0 0.000708059394597755 0.99974171886098 0.999338830952079 0.999929622742193 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.His206fs Rv3083_p.His206fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1693 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.His22Asp Rv3083_p.His22Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 93 0 93 11 124 5201 15363 0.0021105141980046 0.00105401717787221 0.00377314786388412 0.991993284690385 0.990461010054498 0.993336147127216 0.0814814814814814 0.0413775048760789 0.141115484539079 0 0 0.0388889985342758 0 0 0.0293108810897749 0 0 0.119582322145056 2.6200582012708e-12 11 2233 True False 0.262035526666708 0.127379159622933 0.485846091650217 0 0 0.000709012030296245 0.991993284690385 0.990461010054498 0.993336147127216 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 5 14 2165 3776 0.00230414746543778 0.000748560476988087 0.00536885389822181 0.996306068601583 0.993809970169066 0.997979066953146 0.263157894736842 0.0914657849076665 0.512029345345872 0 0 0.409616397225003 0 0 0.231635761650116 0 0 1.2114903112582 0.0531721120223992 41 1065 False False 0 0 0 0 0 0 0 0.622896733751237 0.175373925514018 1.83339685322559 0 0 0.00170241965449235 0.996306068601583 0.993809970169066 0.997979066953146 356 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.His412Arg Rv3083_p.His412Arg 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 16 3 5196 15484 0.00306983883346124 0.00175566480963699 0.00498045124723913 0.999806289145735 0.999434000080036 0.999960050383188 0.842105263157894 0.604215448733325 0.966173750998235 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1616 2233 False False 15.8932512188863 4.54651993923145 85.0865186578223 0 0 0.000709694055296222 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 2 2169 3788 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.999472295514512 0.998095063429584 0.999936086148442 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 788 1065 False False 0 0 0 0 0 0 0 0.87321346242508 0.0147995228023146 16.7833115850342 0 0 0.0016992827759538 0.999472295514512 0.998095063429584 0.999936086148442 17 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.His412Pro Rv3083_p.His412Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1536 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.His458Tyr Rv3083_p.His458Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1663 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 807 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.His484fs Rv3083_p.His484fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1572 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.His492fs Rv3083_p.His492fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1653 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.His99Pro Rv3083_p.His99Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1688 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.His99Tyr Rv3083_p.His99Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 5212 15481 0 0 0.000707516179821284 0.99961257829147 0.999156938222445 0.999857810215121 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 2.52357746319564 0.347651033317578 363.5 2233 False False 0 0 2.52357746319564 0 0 0.000707516179821284 0.99961257829147 0.999156938222445 0.999857810215121 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Ile137Thr Rv3083_p.Ile137Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1583 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Ile17fs Rv3083_p.Ile17fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1704 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Ile17Val Rv3083_p.Ile17Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1626 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Ile226Val Rv3083_p.Ile226Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1627 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Ile250Val Rv3083_p.Ile250Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Ile32fs Rv3083_p.Ile32fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 4 1 5208 15486 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.999935429715245 0.999640290494779 0.999998365223265 0.8 0.28358206388191 0.994949236620532 NA NA NA 0 0 0.975 NA NA NA NA 1525 2233 False False 11.8940092165898 1.17652678598182 583.885453446482 0 0 0.000708059394597755 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 1 2167 3789 0.00138248847926267 0.000285193152965682 0.0040348522148252 0.999736147757256 0.998530795728906 0.999993319861894 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 748 1065 False False 0 0 0 0 0 0 0 5.2455006922012 0.420751345257316 275.029142692281 0 0 0.00170084976888778 0.999736147757256 0.998530795728906 0.999993319861894 2 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Ile32Thr Rv3083_p.Ile32Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 19 0 19 23 19 5189 15468 0.00441289332310053 0.00279939029879314 0.00661419229554572 0.998773164589655 0.998084804605634 0.999261208414407 0.547619047619047 0.386731787237871 0.701541186803682 0 0 0.176466911806965 0 0 0.176466911806965 0 0 0.639063695811473 0.00646993320199422 61 2233 False False 3.60848353297968 1.87794735477525 7.01134463875634 0 0 0.000710651097647743 0.998773164589655 0.998084804605634 0.999261208414407 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 3 4 2167 3786 0.00138248847926267 0.000285193152965682 0.0040348522148252 0.998944591029023 0.997299958285064 0.999712364080324 0.428571428571428 0.0989882784425078 0.815948432359917 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.64909046564391 0.303698415251566 98 1065 False False 0 0 0 0 0 0 0 1.31033687125057 0.191756392649407 7.7545860694147 0 0 0.00170084976888778 0.998944591029023 0.997299958285064 0.999712364080324 50 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Ile337Met Rv3083_p.Ile337Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Ile342Ser Rv3083_p.Ile342Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1679 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Ile401Thr Rv3083_p.Ile401Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1549 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Ile450fs Rv3083_p.Ile450fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1654 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Ile81Ser Rv3083_p.Ile81Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 19 5211 15468 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.998773164589655 0.998084804605634 0.999261208414407 0.05 0.0012650894979498 0.248732762772027 NA NA NA 0 0 0.176466911806965 NA NA NA NA 1632 2233 False False 0.156228221676817 0.00376307557127773 0.983299812298748 0 0 0.000707651905360176 0.998773164589655 0.998084804605634 0.999261208414407 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 4 2169 3786 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.998944591029023 0.997299958285064 0.999712364080324 0.2 0.00505076337946806 0.716417936118089 NA NA NA 0 0 0.602364635616474 NA NA NA NA 794 1065 False False 0 0 0 0 0 0 0 0.436376210235131 0.00886124548211645 4.41391975850517 0 0 0.0016992827759538 0.998944591029023 0.997299958285064 0.999712364080324 83 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Ile85Thr Rv3083_p.Ile85Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Leu150Arg Rv3083_p.Leu150Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Leu173Val Rv3083_p.Leu173Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1668 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 808 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 9 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Leu192Trp Rv3083_p.Leu192Trp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1705 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 819 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0 0 0.00170006591133688 1 0.999027154404229 1 6 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Leu210Arg Rv3083_p.Leu210Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 7.19247409791798 0.577090863007554 439 2233 False False 0 0 7.19247409791798 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 2170 3787 0 0 0.00169850036174098 0.999208443271767 0.997688494809834 0.999836732216022 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.22663965322398 0.558201069943668 269 1065 False False 0 0 0 0 0 0 0 0 0 4.22663965322398 0 0 0.00169850036174098 0.999208443271767 0.997688494809834 0.999836732216022 1 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Leu254Pro Rv3083_p.Leu254Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1655 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 804 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Leu269Pro Rv3083_p.Leu269Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1689 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Leu291Arg Rv3083_p.Leu291Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1557 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Leu297Ser Rv3083_p.Leu297Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1550 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 759 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 7 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Leu330Met Rv3083_p.Leu330Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Leu330Pro Rv3083_p.Leu330Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 5209 15487 0.000575594781273983 0.000118717215010897 0.00168120176197813 1 0.999761836368682 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1573 2233 False False Inf 1.22809956796298 Inf 0 0 0.000707923512718415 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Leu353Pro Rv3083_p.Leu353Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1736 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Leu377Met Rv3083_p.Leu377Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1622 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Leu378Arg Rv3083_p.Leu378Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1611 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Leu397fs Rv3083_p.Leu397fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1597 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 782 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 6 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Leu406fs Rv3083_p.Leu406fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1526 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Leu410Pro Rv3083_p.Leu410Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1602 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 783 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 2 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Leu439Pro Rv3083_p.Leu439Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1645 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 801 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Leu474Pro Rv3083_p.Leu474Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1519 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 746 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Leu75Arg Rv3083_p.Leu75Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 13 0 13 0 21 5212 15466 0 0 0.000707516179821284 0.998644024020146 0.997927989586209 0.999160439688496 0 0 0.161097615219079 0 0 0.24705263800047 0 0 0.161097615219079 0 0 0.974071014917526 0.0482153450324592 97 2233 False False 0 0 0.570115169450023 0 0 0.000707516179821284 0.998644024020146 0.997927989586209 0.999160439688496 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 2 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Leu75Pro Rv3083_p.Leu75Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Leu8fs Rv3083_p.Leu8fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Lys253* Rv3083_p.Lys253* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1694 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Lys374Asn Rv3083_p.Lys374Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1656 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Lys374fs Rv3083_p.Lys374fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1584 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Lys374Glu Rv3083_p.Lys374Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1628 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Lys457Thr Rv3083_p.Lys457Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1737 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Lys471Asn Rv3083_p.Lys471Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Lys73Thr Rv3083_p.Lys73Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1574 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 770 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Met209Ile Rv3083_p.Met209Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1623 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Met209Thr Rv3083_p.Met209Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 2 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Met283Ile Rv3083_p.Met283Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Met352Thr Rv3083_p.Met352Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1738 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 832 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Met356fs Rv3083_p.Met356fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1695 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Met371Ile Rv3083_p.Met371Ile 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 7 6 5205 15481 0.00134305448963929 0.000540142673187124 0.00276523543039201 0.99961257829147 0.999156938222445 0.999857810215121 0.538461538461538 0.251345482270303 0.807767558198712 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1537 2233 False False 3.46996477745757 0.997956294931619 12.5063013275122 0 0 0.000708467353397108 0.99961257829147 0.999156938222445 0.999857810215121 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 56 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Met451Val Rv3083_p.Met451Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 18 0 18 1 22 5211 15465 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99857945373539 0.997850061160787 0.999109543803372 0.0434782608695652 0.0011001686304415 0.21948660745348 0 0 0.185301968137852 0 0 0.154372512815574 0 0 0.675328899153035 0.0110957766148904 65 2233 False False 0.134898204846391 0.00327188167770355 0.835023815799735 0 0 0.000707651905360176 0.99857945373539 0.997850061160787 0.999109543803372 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 13 0 13 0 14 2170 3776 0 0 0.00169850036174098 0.996306068601583 0.993809970169066 0.997979066953146 0 0 0.231635761650116 0 0 0.24705263800047 0 0 0.231635761650116 0 0 0.571717755086888 0.0032673164783928 22 1065 False False 0 0 0 0 0 0 0 0 0 0.525286526388396 0 0 0.00169850036174098 0.996306068601583 0.993809970169066 0.997979066953146 9 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Met464fs Rv3083_p.Met464fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1558 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 763 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Phe27fs Rv3083_p.Phe27fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1696 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Phe286Val Rv3083_p.Phe286Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1739 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Phe324Ser Rv3083_p.Phe324Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Phe5Leu Rv3083_p.Phe5Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Phe60fs Rv3083_p.Phe60fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1718 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Phe66fs Rv3083_p.Phe66fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1603 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Pro201Arg Rv3083_p.Pro201Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1538 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 752 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Pro214Arg Rv3083_p.Pro214Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Pro235Leu Rv3083_p.Pro235Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1527 2233 False False 0 0 7.19247409791798 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Pro288Ser Rv3083_p.Pro288Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1719 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Pro292Ser Rv3083_p.Pro292Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1669 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 809 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Pro382Arg Rv3083_p.Pro382Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1528 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 749 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Pro382Leu Rv3083_p.Pro382Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 4 1 5208 15486 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.999935429715245 0.999640290494779 0.999998365223265 0.8 0.28358206388191 0.994949236620532 NA NA NA 0 0 0.975 NA NA NA NA 1568 2233 False False 11.8940092165898 1.17652678598182 583.885453446482 0 0 0.000708059394597755 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Pro423Leu Rv3083_p.Pro423Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Pro459fs Rv3083_p.Pro459fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Pro68Arg Rv3083_p.Pro68Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Pro68fs Rv3083_p.Pro68fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1649 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Ser111Ile Rv3083_p.Ser111Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1633 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 795 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 45 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Ser138Asn Rv3083_p.Ser138Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1612 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Ser176Ala Rv3083_p.Ser176Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1617 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 789 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 8 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Ser213_Arg267del Rv3083_p.Ser213_Arg267del 2 inframe_deletion (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1657 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Ser213Ala Rv3083_p.Ser213Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1634 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 796 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 2 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Ser213fs Rv3083_p.Ser213fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1712 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Ser213Pro Rv3083_p.Ser213Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1559 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 764 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Ser215fs Rv3083_p.Ser215fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 1 2 5211 15485 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1713 2233 False False 1.48579927077336 0.0251793916671698 28.5526337681963 0 0 0.000707651905360176 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 822 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Ser219Ala Rv3083_p.Ser219Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Ser219Pro Rv3083_p.Ser219Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Ser284fs Rv3083_p.Ser284fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 115.662511114998 1 815 2233 False False 0 0 7.19247409791798 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Ser284Gly Rv3083_p.Ser284Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1560 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Ser311Ala Rv3083_p.Ser311Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Ser311Pro Rv3083_p.Ser311Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1729 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 2168 3790 0.000921658986175115 0.000111636674590768 0.0033253435449308 1 0.999027154404229 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 827 1065 False False 0 0 0 0 0 0 0 Inf 0.328088282833639 Inf 0 0 0.00170006591133688 1 0.999027154404229 1 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Ser333Pro Rv3083_p.Ser333Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1561 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 765 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Ser441_Gly442delinsCys Rv3083_p.Ser441_Gly442delinsCys 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Ser441Pro Rv3083_p.Ser441Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1664 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Ser456fs Rv3083_p.Ser456fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1585 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 774 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Ser55Leu Rv3083_p.Ser55Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Ser57Pro Rv3083_p.Ser57Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1586 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Ser80Pro Rv3083_p.Ser80Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1569 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Thr128fs Rv3083_p.Thr128fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1635 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 797 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Thr188Ala Rv3083_p.Thr188Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1562 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Thr191Ala Rv3083_p.Thr191Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1730 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 828 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Thr19Pro Rv3083_p.Thr19Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Thr208Met Rv3083_p.Thr208Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 115.669966941234 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 775 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 1 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Thr308fs Rv3083_p.Thr308fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1580 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 773 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Thr323Pro Rv3083_p.Thr323Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1680 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Thr396Pro Rv3083_p.Thr396Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1697 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Thr419Ala Rv3083_p.Thr419Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1681 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Thr419Lys Rv3083_p.Thr419Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Thr419Met Rv3083_p.Thr419Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1539 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Thr422fs Rv3083_p.Thr422fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1731 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Thr61Ala Rv3083_p.Thr61Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Thr61fs Rv3083_p.Thr61fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1720 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Thr90Met Rv3083_p.Thr90Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 6 5212 15481 0 0 0.000707516179821284 0.99961257829147 0.999156938222445 0.999857810215121 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1618 2233 False False 0 0 2.52357746319564 0 0 0.000707516179821284 0.99961257829147 0.999156938222445 0.999857810215121 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Trp109* Rv3083_p.Trp109* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 5211 15486 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.999935429715245 0.999640290494779 0.999998365223265 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1529 2233 False False 2.97179044329303 0.0378514560716107 232.854636669753 0 0 0.000707651905360176 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Trp116* Rv3083_p.Trp116* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1629 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Trp169Arg Rv3083_p.Trp169Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1587 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Trp261* Rv3083_p.Trp261* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 2 1 5210 15486 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.999935429715245 0.999640290494779 0.999998365223265 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 1706 2233 False False 5.9447216890595 0.309382652589367 349.949104522224 0 0 0.000707787682982558 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Trp271* Rv3083_p.Trp271* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 4 2 5208 15485 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.99987085943049 0.99953357854254 0.999984360095269 0.666666666666666 0.222778095503512 0.956728131707258 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1588 2233 False False 5.94662058371735 0.851897563491887 65.8224106582454 0 0 0.000708059394597755 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 776 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 52 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Trp293Arg Rv3083_p.Trp293Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1690 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 815 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Trp293* Rv3083_p.Trp293* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1714 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Trp386* Rv3083_p.Trp386* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 5208 15487 0.00076745970836531 0.000209145270149598 0.00196382534650725 1 0.999761836368682 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 1594 2233 False False Inf 1.96217557721065 Inf 0 0 0.000708059394597755 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 2166 3790 0.00184331797235023 0.00050246332413509 0.00471284227984187 1 0.999027154404229 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 781 1065 False False 0 0 0 0 0 0 0 Inf 1.15374841388447 Inf 0 0 0.00170163434960586 1 0.999027154404229 1 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Trp45Arg Rv3083_p.Trp45Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1698 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Trp45Leu Rv3083_p.Trp45Leu 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1658 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Trp460Arg Rv3083_p.Trp460Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1630 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Trp460* Rv3083_p.Trp460* 2 stop_gained (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Trp69* Rv3083_p.Trp69* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1570 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Tyr100Asp Rv3083_p.Tyr100Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Tyr131Asp Rv3083_p.Tyr131Asp 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 9 26 5203 15461 0.00172678434382194 0.000789890217063144 0.00327543249467561 0.998321172596371 0.997541089641407 0.998903050216343 0.257142857142857 0.124893971916761 0.432558849694038 NA NA NA 0 0 0.132274604497754 NA NA NA NA 1721 2233 False False 1.02861514806546 0.4238124800617 2.26714054603757 0 0 0.000708739587198625 0.998321172596371 0.997541089641407 0.998903050216343 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 6 9 2164 3781 0.00276497695852534 0.00101535276242503 0.00600840604626057 0.997625329815303 0.995496943566885 0.998913592562977 0.4 0.163364323859513 0.677130233793718 NA NA NA 0 0 0.336267116879942 NA NA NA NA 824 1065 False False 0 0 0 0 0 0 0 1.16481823783117 0.340665065608429 3.66979258750474 0 0 0.00170320568455034 0.997625329815303 0.995496943566885 0.998913592562977 86 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Tyr131Cys Rv3083_p.Tyr131Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1589 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 777 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Tyr131* Rv3083_p.Tyr131* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1682 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 813 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Tyr135Cys Rv3083_p.Tyr135Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1540 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 753 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Tyr145Asp Rv3083_p.Tyr145Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1715 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Tyr145Cys Rv3083_p.Tyr145Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 5211 15485 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.99987085943049 0.99953357854254 0.999984360095269 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8263323782973 1 815 2233 False False 1.48579927077336 0.0251793916671698 28.5526337681963 0 0 0.000707651905360176 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Tyr149fs Rv3083_p.Tyr149fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Tyr216Cys Rv3083_p.Tyr216Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 5212 15484 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 15.8222760528043 1 815 2233 False False 0 0 7.19247409791798 0 0 0.000707516179821284 0.999806289145735 0.999434000080036 0.999960050383188 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Tyr240His Rv3083_p.Tyr240His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1732 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Tyr365His Rv3083_p.Tyr365His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1563 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 766 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Tyr405fs Rv3083_p.Tyr405fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1571 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Tyr418Cys Rv3083_p.Tyr418Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1665 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Tyr466Asp Rv3083_p.Tyr466Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1619 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 790 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Tyr64Ser Rv3083_p.Tyr64Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1716 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 823 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Tyr84Cys Rv3083_p.Tyr84Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1666 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Tyr84His Rv3083_p.Tyr84His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1707 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 820 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 2 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Val118Gly Rv3083_p.Val118Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1722 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Val121fs Rv3083_p.Val121fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 4 2 5208 15485 0.00076745970836531 0.000209145270149598 0.00196382534650725 0.99987085943049 0.99953357854254 0.999984360095269 0.666666666666666 0.222778095503512 0.956728131707258 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1520 2233 False False 5.94662058371735 0.851897563491887 65.8224106582454 0 0 0.000708059394597755 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 747 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 8 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Val229Ala Rv3083_p.Val229Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1673 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Val229Ile Rv3083_p.Val229Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1650 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 803 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 8 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Val273fs Rv3083_p.Val273fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1683 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 2170 3788 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 814 1065 False False 0 0 0 0 0 0 0 0 0 9.2999762698034 0 0 0.00169850036174098 0.999472295514512 0.998095063429584 0.999936086148442 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Val281Met Rv3083_p.Val281Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1598 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Val316Gly Rv3083_p.Val316Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1670 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Val316Met Rv3083_p.Val316Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1708 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Val317Ala Rv3083_p.Val317Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1733 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 829 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Val376Ala Rv3083_p.Val376Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5210 15487 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 1 0.999761836368682 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1674 2233 False False Inf 0.55810577429468 Inf 0 0 0.000707787682982558 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Val376Leu Rv3083_p.Val376Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5212 15485 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 15.8232972540303 1 815 2233 False False 0 0 15.8232972540303 0 0 0.000707516179821284 0.99987085943049 0.99953357854254 0.999984360095269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Val433Ile Rv3083_p.Val433Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 0 0 0.975 0 0 0.975 0 0 115.677422765729 1 815 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 0 0 0.975 0 0 0.975 0 0 68.0438514794824 1 405 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance New Uncertain no 0 +Ethionamide Rv3083 p.Val462Met Rv3083_p.Val462Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5212 15486 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1723 2233 False False 0 0 115.677422765729 0 0 0.000707516179821284 0.999935429715245 0.999640290494779 0.999998365223265 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2170 3789 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 825 1065 False False 0 0 0 0 0 0 0 0 0 68.0438514794824 0 0 0.00169850036174098 0.999736147757256 0.998530795728906 0.999993319861894 NA 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Val7Phe Rv3083_p.Val7Phe 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 76 5211 15411 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 0.995092658358623 0.993861525731679 0.996131682450383 0.0129870129870129 0.000328748651410606 0.0702470606475967 NA NA NA 0 0 0.0473787538669306 NA NA NA NA 1604 2233 False False 0.0389131291094749 0.000976696916797824 0.22357080724718 0 0 0.000707651905360176 0.995092658358623 0.993861525731679 0.996131682450383 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 7 2170 3783 0 0 0.00169850036174098 0.998153034300791 0.996198270365656 0.999257111678459 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 784 1065 False False 0 0 0 0 0 0 0 0 0 1.21093665138412 0 0 0.00169850036174098 0.998153034300791 0.996198270365656 0.999257111678459 39 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Val94Ile Rv3083_p.Val94Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 18 0 18 2 45 5210 15442 0.000383729854182655 4.64748443607068e-05 0.00138546957733054 0.997094337186027 0.996113904923128 0.997879824073927 0.0425531914893617 0.00519558317674383 0.145405245488214 0 0 0.185301968137852 0 0 0.078705100406843 0 0 0.67445421980665 0.0111069084916 66 2233 False False 0.131729579867775 0.0154592733829523 0.504631038209375 0 0 0.000707787682982558 0.997094337186027 0.996113904923128 0.997879824073927 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 1 14 2169 3776 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 0.996306068601583 0.993809970169066 0.997979066953146 0.0666666666666666 0.0016864302413527 0.319484566578303 0 0 0.521823750104981 0 0 0.231635761650116 0 0 1.9018030739769 0.165987594851563 70 1065 False False 0 0 0 0 0 0 0 0.124349601528024 0.00294363816399205 0.818553797954805 0 0 0.0016992827759538 0.996306068601583 0.993809970169066 0.997979066953146 258 3) Uncertain significance No change no 1 +Ethionamide Rv3083 p.Val94Phe Rv3083_p.Val94Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5211 15487 0.000191864927091327 4.85758758490123e-06 0.00106853423925776 1 0.999761836368682 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1734 2233 False False Inf 0.0761899451219867 Inf 0 0 0.000707651905360176 1 0.999761836368682 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2169 3790 0.000460829493087557 1.16671245580613e-05 0.00256487461233225 1 0.999027154404229 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 830 1065 False False 0 0 0 0 0 0 0 Inf 0.0447829748447436 Inf 0 0 0.0016992827759538 1 0.999027154404229 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC c.-10G>A ahpC_c.-10G>A 1 upstream_gene_variant 2726183 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC c.114C>T ahpC_c.114C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.129C>T ahpC_c.129C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.63548263289195 0.137183409715989 155.34952410964 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.132A>G ahpC_c.132A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.135C>A ahpC_c.135C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.138G>A ahpC_c.138G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.-13G>T ahpC_c.-13G>T 1 upstream_gene_variant 2726180 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2811 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid ahpC c.15C>T ahpC_c.15C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.165A>G ahpC_c.165A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.869878292971449 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.-16G>A ahpC_c.-16G>A 1 upstream_gene_variant 2726177 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid ahpC c.177C>T ahpC_c.177C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.186T>A ahpC_c.186T>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 54 20846 27414 0 0 0.00017694296670111 0.998034076015727 0.997435664335305 0.9985228029218 0 0 0.0660315142444217 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 0 0.0929887466966249 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 0 44 13374 21269 0 0 0.000275786657608973 0.997935532304227 0.997229528416783 0.99849956619829 0 0 0.0804199397635758 NA NA NA NA NA NA NA NA NA NA NA NA False True 1 1 1 0 0 0 0 0 0 0.139114981028719 NA NA NA NA NA NA 7 5) Not assoc w R Now listed Silent mutation no 0 +Isoniazid ahpC c.18T>C ahpC_c.18T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 69 157 20777 27311 0.00330998752758322 0.00257625301236597 0.00418715903527833 0.994284258045726 0.993320207309637 0.995141360248586 0.305309734513274 0.245968558160562 0.369842397669608 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.577702438604176 0.428518983845558 0.771967218848803 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 50 127 13324 21186 0.00373859727830118 0.00277609390017742 0.00492593960325385 0.994041195514474 0.992914166958447 0.995030063408348 0.282485875706214 0.217499398774457 0.354915737918874 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 0 1 0 0 0 1 0.626009072492477 0.441641415181786 0.875536230603654 NA NA NA NA NA NA 15 Literature evidence (PMID 32143680) 4) Not assoc w R - Interim Now listed Silent mutation no Lit. (PMID 32143680) 0 +Isoniazid ahpC c.192G>A ahpC_c.192G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.21C>A ahpC_c.21C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.237C>T ahpC_c.237C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.252G>A ahpC_c.252G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.252G>T ahpC_c.252G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.276G>A ahpC_c.276G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 27 21 20819 27447 0.00129521251079343 0.000853721301750774 0.00188391092655412 0.999235474006116 0.998831576963824 0.999526686034611 0.5625 0.411808358840645 0.705198758666167 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.69503818627215 0.922692516986149 3.15470232444201 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 14 17 13360 21296 0.00104680723792433 0.000572413688832994 0.00175574154681136 0.999202364753906 0.998723214865585 0.999535281595187 0.451612903225806 0.273164986003735 0.639657672839183 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.31271574498062 0.598850535520095 2.83075456309863 NA NA NA NA NA NA 11 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.291T>C ahpC_c.291T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.297G>A ahpC_c.297G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.-3_-2insT ahpC_c.-3_-2insT 1 upstream_gene_variant 2726190 1 7 0 7 0 7 20846 27461 0 0 0.00017694296670111 0.999745158002038 0.999474999027776 0.999897534357495 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.914121240039481 0.0219749245408003 156 5574 False False 0 0 0.914121240039481 0 0 0.00017694296670111 0.999745158002038 0.999474999027776 0.999897534357495 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 7 13374 21306 0 0 0.000275786657608973 0.99967156195749 0.999323409938814 0.999867941002665 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 1.10552510564584 0.0484388314759391 130.5 4479 False False 0 0 0 0 0 0 0 0 0 1.10552510564584 0 0 0.000275786657608973 0.99967156195749 0.999323409938814 0.999867941002665 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC c.327G>A ahpC_c.327G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.336C>T ahpC_c.336C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 3 2 20843 27466 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999927188000582 0.999737003036386 0.999991182007438 0.6 0.146632799634673 0.947255049473683 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.97663484143357 0.226402568392661 23.6672561646805 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.339C>T ahpC_c.339C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.-34delA ahpC_c.-34delA 1 upstream_gene_variant 2726158 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC c.363C>T ahpC_c.363C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.36C>A ahpC_c.36C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.-36C>T ahpC_c.-36C>T 1 upstream_gene_variant 2726157 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC c.372C>G ahpC_c.372C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.372C>T ahpC_c.372C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.375C>A ahpC_c.375C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.381C>T ahpC_c.381C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.-39C>T ahpC_c.-39C>T 1 upstream_gene_variant 2726154 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2839 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC c.-3G>C ahpC_c.-3G>C 1 upstream_gene_variant 2726190 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2830 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2312 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC c.402G>A ahpC_c.402G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.-40G>A ahpC_c.-40G>A 1 upstream_gene_variant 2726153 1 3 0 3 2 6 20844 27462 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999781564001747 0.999524617886493 0.999919833755107 0.25 0.0318540262499442 0.650855794412824 0 0 0.707598226178713 0 0 0.4592581264399 0 0 3.18861083853511 0.264072863597706 450 5574 False False 0.439167146421032 0.0433460282809438 2.45619176778693 0 0 0.000176959943030976 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 6 13373 21307 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999718481677849 0.999387354605726 0.999896680954833 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.707598226178713 0 0 0.4592581264399 0 0 3.8562638373614 0.289256724812702 286 4479 False False 0 0 0 0 0 0 0 0.265547496198808 0.00577686092206708 2.18912593855065 0 0 0.000275807277411719 0.999718481677849 0.999387354605726 0.999896680954833 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC c.-41C>A ahpC_c.-41C>A 1 upstream_gene_variant 2726152 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2851 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid ahpC c.-41C>T ahpC_c.-41C>T 1 upstream_gene_variant 2726152 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2805 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2292 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC c.429G>A ahpC_c.429G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.-42T>G ahpC_c.-42T>G 1 upstream_gene_variant 2726151 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2843 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2322 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC c.432C>T ahpC_c.432C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.-43G>A ahpC_c.-43G>A 1 upstream_gene_variant 2726150 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2849 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC c.-44_-43insC ahpC_c.-44_-43insC 1 upstream_gene_variant 2726149 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2803 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2290 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC c.444G>A ahpC_c.444G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 6 20 20840 27448 0.000287825002398541 0.000105633792978048 0.000626367784710498 0.999271880005825 0.998875700613314 0.999555190458412 0.23076923076923 0.0897401108845751 0.436475096941386 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.395124760076775 0.129826453761761 1.02038758267621 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 3 13 13371 21300 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.99939004363534 0.998957181904114 0.999675185224884 0.1875 0.0404737339059459 0.456456546231611 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.367615332838577 0.0671805522637574 1.33817896767753 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.-44delT ahpC_c.-44delT 1 upstream_gene_variant 2726148 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2807 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC c.-45A>G ahpC_c.-45A>G 1 upstream_gene_variant 2726148 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC c.45C>G ahpC_c.45C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.462G>C ahpC_c.462G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.465A>C ahpC_c.465A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.247471899512553 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.468C>G ahpC_c.468C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.99604811372315 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.41420404242617 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.-47_-46insT ahpC_c.-47_-46insT 1 upstream_gene_variant 2726146 0 0 0 0 78 0 20768 27468 0.00374172503118104 0.00295876822164733 0.00466767380859357 1 0.999865711673152 1 1 0.953807579671951 1 NA NA NA NA NA NA NA NA NA NA 2844 5574 False False Inf 27.2896486506239 Inf 0 0 0.000177607466205201 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 34 0 13340 21313 0.0025422461492448 0.00176120219231411 0.00355073915576892 1 0.999826933785262 1 1 0.897182075740987 1 NA NA NA NA NA NA NA NA NA NA 2323 4479 False False 0 0 0 0 0 0 0 Inf 13.9370542429277 Inf 0 0 0.00027648946495182 1 0.999826933785262 1 5 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC c.480G>A ahpC_c.480G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 7 20845 27461 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999745158002038 0.999474999027776 0.999897534357495 0.125 0.0031597235312519 0.526509670875206 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.188198608779083 0.00417990056987037 1.46513319151887 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 7 13373 21306 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.99967156195749 0.999323409938814 0.999867941002665 0.125 0.0031597235312519 0.526509670875206 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.227601457093717 0.00505385949080816 1.77192833352817 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.489A>C ahpC_c.489A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.48C>G ahpC_c.48C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.-48G>A ahpC_c.-48G>A 1 upstream_gene_variant 2726145 1 5 2 3 170 14 20676 27454 0.00815504173462534 0.00697916213652983 0.00947100917663124 0.999490316004077 0.999144984581285 0.999721323894632 0.92391304347826 0.875633703222998 0.957779647067838 0.4 0.0527449505263169 0.853367200365326 0.125 0.0155136038154138 0.383476236849263 0.885213129554394 0.0739021141444162 7.72888241925436 1 1253.5 5574 False False 16.1235248597407 9.34418037762992 30.1077079983188 9.67211529161427e-05 1.17135949726528e-05 0.000349345923124583 0.999490316004077 0.999144984581285 0.999721323894632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 114 7 13260 21306 0.00852400179452669 0.00703624874713763 0.0102311312778671 0.99967156195749 0.999323409938814 0.999867941002665 0.942148760330578 0.884434378724741 0.97642711828444 0.333333333333333 0.00840375865961264 0.905700675949754 0.125 0.0031597235312519 0.526509670875206 0.803393665158371 0.0136218448581132 15.434375845375 1 1005 4479 False False 0 0 0 0 0 0 0 26.167679379444 12.2911760346592 66.5476506687719 7.5409094336777e-05 1.90919114817998e-06 0.000420080166800571 0.99967156195749 0.999323409938814 0.999867941002665 39 3) Uncertain significance No change no 1 +Isoniazid ahpC c.495C>A ahpC_c.495C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 11 20846 27457 0 0 0.00017694296670111 0.999599534003203 0.9992835689522 0.999800072407065 0 0 0.284914152918154 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.524869354994364 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 10 13374 21303 0 0 0.000275786657608973 0.999530802796415 0.99913729947772 0.999774979505452 0 0 0.30849710781876 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.710765762832934 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.-51G>A ahpC_c.-51G>A 1 upstream_gene_variant 2726142 1 3 0 3 67 14 20779 27454 0.00321404586011704 0.00249168323307316 0.00407995295685922 0.999490316004077 0.999144984581285 0.999721323894632 0.82716049382716 0.727041256277668 0.902158161484 0 0 0.707598226178713 0 0 0.231635761650116 0 0 3.19765430529493 0.264359870507443 578 5574 False False 6.32306655758217 3.51804342260134 12.1869378775921 0 0 0.00017751345259937 0.999490316004077 0.999144984581285 0.999721323894632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 43 13 13331 21300 0.00321519365933901 0.0023277991690822 0.00432842794483404 0.99939004363534 0.998957181904114 0.999675185224884 0.767857142857142 0.635815748349161 0.870207967213133 0 0 0.841886116991581 0 0 0.24705263800047 0 0 8.50832882060112 0.526472267629545 986 4479 False False 0 0 0 0 0 0 0 5.28496333012123 2.78799204385988 10.7187137616983 0 0 0.000276676102181712 0.99939004363534 0.998957181904114 0.999675185224884 11 3) Uncertain significance No change no 1 +Isoniazid ahpC c.-52C>A ahpC_c.-52C>A 1 upstream_gene_variant 2726141 1 4 1 3 92 4 20754 27464 0.0044133167034443 0.00355919477785606 0.00540983499518101 0.999854376001165 0.999627187086024 0.999960320981843 0.958333333333333 0.896742555550181 0.988532310833867 0.25 0.00630946320970987 0.805879550316756 0.2 0.00505076337946806 0.716417936118089 0.441103722977096 0.00840686621390561 5.49423674875884 0.639375185522625 1233 5574 False False 30.4361568854196 11.4878327076798 114.22778412001 4.81811611659841e-05 1.2198406428543e-06 0.000268418684887866 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 32 2 13342 21311 0.00239270225811275 0.00163716457667549 0.00337611758106976 0.999906160559283 0.999661061221376 0.999988635406343 0.941176470588235 0.803226790664424 0.99279508256095 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.798643381801828 0.0135413436482245 15.3431228267554 1 1642.5 4479 False False 0 0 0 0 0 0 0 25.5565882176585 6.51876741804757 219.186069468352 7.49456643933148e-05 1.897458140189e-06 0.000417498987703143 0.999906160559283 0.999661061221376 0.999988635406343 1 3) Uncertain significance No change no 1 +Isoniazid ahpC c.-52C>G ahpC_c.-52C>G 1 upstream_gene_variant 2726141 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2832 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2313 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC c.-52C>T ahpC_c.-52C>T 1 upstream_gene_variant 2726141 1 8 4 4 96 9 20750 27459 0.00460520003837666 0.00373177152543466 0.00562087123517574 0.999672346002621 0.99937810218515 0.999850165132458 0.914285714285714 0.843516676794531 0.960054640371146 0.5 0.157012770487058 0.842987229512941 0.307692307692307 0.0909203945720966 0.614261661750705 1.32332530120481 0.246447863899355 7.10573171948558 0.732290891170635 1237 5574 False False 14.115469879518 7.13006651447902 31.808840957903598 0.000192733930808518 5.2515926161063e-05 0.00049340121076593 0.999672346002621 0.99937810218515 0.999850165132458 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 3 4 56 7 13318 21306 0.00418722895169732 0.00316449143546909 0.00543406401984753 0.99967156195749 0.999323409938814 0.999867941002665 0.888888888888888 0.784375751297472 0.954143376283129 0.428571428571428 0.0989882784425078 0.815948432359917 0.3 0.0667395111777345 0.652452850059997 1.19984231866646 0.17572697798146 7.09348392838939 1 1642.5 4479 False False 0 0 0 0 0 0 0 12.7983180657756 5.81687352683618 33.2945949772203 0.000225208317693866 4.64457775354779e-05 0.000658011813783552 0.99967156195749 0.999323409938814 0.999867941002665 8 3) Uncertain significance No change no 1 +Isoniazid ahpC c.-53A>G ahpC_c.-53A>G 1 upstream_gene_variant 2726140 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC c.-54_-53insT ahpC_c.-54_-53insT 1 upstream_gene_variant 2726139 1 1 1 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0337875782094303 Inf 0.431457371721896 645 5574 False False Inf 0.247471899512553 Inf 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC c.549G>A ahpC_c.549G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.549G>C ahpC_c.549G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.-54C>A ahpC_c.-54C>A 1 upstream_gene_variant 2726139 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2797 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2285 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC c.54C>T ahpC_c.54C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.-54C>T ahpC_c.-54C>T 1 upstream_gene_variant 2726139 1 1 1 0 44 3 20802 27465 0.00211071668425597 0.00153405599169297 0.00283251428793564 0.999890782000873 0.99968085216583 0.999977476056514 0.936170212765957 0.824607569987079 0.986638230502745 1 0.025 1 0.25 0.00630946320970987 0.805879550316756 Inf 0.0338520966917042 Inf 0.430989475428855 591 5574 False False 19.364484184213 6.206617643657 97.5716024965874 4.80699899053021e-05 1.2170260336524e-06 0.000267799414532624 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 0 1 25 2 13349 21311 0.00186929863915059 0.00121006548869323 0.00275822519578355 0.999906160559283 0.999661061221376 0.999988635406343 0.925925925925926 0.757101653154372 0.990899927057693 0 0 0.975 0 0 0.841886116991581 0 0 62.2048932228412 1 1642.5 4479 False False 0 0 0 0 0 0 0 19.9556146527829 4.97431729497115 173.578167878985 0 0 0.000276303079351708 0.999906160559283 0.999661061221376 0.999988635406343 10 3) Uncertain significance No change no 1 +Isoniazid ahpC c.552G>A ahpC_c.552G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.561T>G ahpC_c.561T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.658815063564403 0.011171855707321 12.6567401482543 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.564C>T ahpC_c.564C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.247471899512553 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.567A>G ahpC_c.567A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.-56G>A ahpC_c.-56G>A 1 upstream_gene_variant 2726137 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2833 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2314 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC c.570C>A ahpC_c.570C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.247471899512553 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.-57C>T ahpC_c.-57C>T 1 upstream_gene_variant 2726136 1 1 1 0 47 2 20799 27466 0.00225462918545524 0.00165707267502761 0.00299706387873752 0.999927188000582 0.999737003036386 0.999991182007438 0.959183673469387 0.860212812977536 0.995018158165028 1 0.025 1 0.333333333333333 0.00840375865961264 0.905700675949754 Inf 0.0338582120381484 Inf 0.430945178800812 590 5574 False False 31.0327900379825 8.12407352279435 261.762022162135 4.8076923076923e-05 1.21720156614658e-06 0.000267838035203555 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 33 1 13341 21312 0.00246747420367878 0.00169908577453598 0.00346352196626117 0.999953080279641 0.999738608085756 0.999998812096234 0.970588235294117 0.846732330439682 0.999255635765309 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0409577733903731 Inf 0.385006059906504 471 4479 False False 0 0 0 0 0 0 0 52.716887789521 8.82171383997881 2121.91196895315 7.49512816669165e-05 1.89760035697358e-06 0.000417530274426376 0.999953080279641 0.999738608085756 0.999998812096234 6 3) Uncertain significance No change no 1 +Isoniazid ahpC c.582G>A ahpC_c.582G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.585C>T ahpC_c.585C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.587A>G ahpC_c.587A>G 1 stop_retained_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.63T>C ahpC_c.63T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.66C>T ahpC_c.66C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.67C>T ahpC_c.67C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.-67delA ahpC_c.-67delA 1 upstream_gene_variant 2726125 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC c.69G>T ahpC_c.69G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 14 20846 27454 0 0 0.00017694296670111 0.999490316004077 0.999144984581285 0.999721323894632 0 0 0.231635761650116 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.397069295701206 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 14 13374 21299 0 0 0.000275786657608973 0.999343123914981 0.998898118907794 0.999640834680135 0 0 0.231635761650116 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.480214320813834 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.-72C>T ahpC_c.-72C>T 1 upstream_gene_variant 2726121 1 6 2 4 37 4 20809 27464 0.00177492084812434 0.00125000646824535 0.00244567292189314 0.999854376001165 0.999627187086024 0.999960320981843 0.902439024390244 0.768685450690538 0.972772533201639 0.333333333333333 0.0432718682927417 0.777221904496487 0.333333333333333 0.0432718682927417 0.777221904496487 0.659906771108654 0.059660489079729 4.60509484977961 0.704970625113537 1234 5574 False False 12.2082752655101 4.38528855373486 47.1545486050238 9.61030224400557e-05 1.16387337695936e-05 0.000347113585639235 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 1 4 17 4 13357 21309 0.0012711230746224 0.000740644897312986 0.00203441363276193 0.999812321118566 0.999519537882235 0.999948861529775 0.809523809523809 0.580933958816472 0.945536431821593 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 0.398835816425844 0.00810244810490628 4.03104609247852 0.655160970908572 1000 4479 False False 0 0 0 0 0 0 0 6.78020887923935 2.2107049444884 27.7023273354881 7.4861506213505e-05 1.89532744359291e-06 0.000417030248879549 0.999812321118566 0.999519537882235 0.999948861529775 2 3) Uncertain significance No change no 1 +Isoniazid ahpC c.-74G>A ahpC_c.-74G>A 1 upstream_gene_variant 2726119 1 1 0 1 17 1 20829 27467 0.000815504173462534 0.000475130725961031 0.00130538114673077 0.999963594000291 0.999797175631493 0.999999078280314 0.944444444444444 0.727056400326631 0.99859444383263 0 0 0.975 0 0 0.975 0 0 51.3902990181465 1 2027.5 5574 False False 22.4177348888568 3.51196841137808 932.886543685562 0 0 0.000177087369412526 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 7 1 13367 21312 0.000523403618962165 0.000210460468745924 0.00107811225334149 0.999953080279641 0.999738608085756 0.999998812096234 0.875 0.473490329124793 0.996840276468748 0 0 0.975 0 0 0.975 0 0 62.1241214470754 1 1642.5 4479 False False 0 0 0 0 0 0 0 11.1606194359242 1.43348631137374 501.805825213892 0 0 0.000275931061008045 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC c.-75T>A ahpC_c.-75T>A 1 upstream_gene_variant 2726118 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2791 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC c.-75T>G ahpC_c.-75T>G 1 upstream_gene_variant 2726118 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC c.-76T>A ahpC_c.-76T>A 1 upstream_gene_variant 2726117 1 4 4 0 27 0 20819 27468 0.00129521251079343 0.000853721301750774 0.00188391092655412 1 0.999865711673152 1 1 0.872297132384567 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 0.870839279535482 Inf 0.0345650521520551 177 5574 False False Inf 9.00875486139632 Inf 0.000192095279258512 5.23418991177097e-05 0.000491766500061528 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 4 0 20 0 13354 21313 0.00149543891132047 0.000913684725149316 0.00230864386780147 1 0.999826933785262 1 1 0.831566529016914 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 1.05336153317291 Inf 0.0220282681923716 113 4479 False False 0 0 0 0 0 0 0 Inf 7.87776979048218 Inf 0.00029944602485402 8.15947975891681e-05 0.000766521647903092 1 0.999826933785262 1 5 3) Uncertain significance No change no 1 +Isoniazid ahpC c.-76T>G ahpC_c.-76T>G 1 upstream_gene_variant 2726117 0 0 0 0 6 0 20840 27468 0.000287825002398541 0.000105633792978048 0.000626367784710498 1 0.999865711673152 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 2801 5574 False False Inf 1.55167078958407 Inf 0 0 0.000176993905465082 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 5 0 13369 21313 0.000373859727830118 0.000121402023062639 0.000872246401868143 1 0.999826933785262 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 2288 4479 False False 0 0 0 0 0 0 0 Inf 1.46057233596553 Inf 0 0 0.000275889787465637 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC c.-77_-76delTT ahpC_c.-77_-76delTT 1 upstream_gene_variant 2726115 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2813 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2297 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC c.-77delT ahpC_c.-77delT 1 upstream_gene_variant 2726115 1 1 1 0 16 0 20830 27468 0.000767533339729444 0.000438773245501675 0.00124612759964746 1 0.999865711673152 1 1 0.794092785792177 1 1 0.025 1 1 0.025 1 Inf 0.0338102863805 Inf 0.431292573345203 594 5574 False False Inf 5.0841332374657 Inf 4.80053766021794e-05 1.21539016844027e-06 0.000267439491302368 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 11 0 13363 21313 0.000822491401226259 0.000410653977896139 0.00147118664271154 1 0.999826933785262 1 1 0.715085847081845 1 1 0.025 1 1 0.025 1 Inf 0.0408922660640232 Inf 0.385385125587565 475 4479 False False 0 0 0 0 0 0 0 Inf 4.00162721599209 Inf 7.4827895839569e-05 1.89447650421177e-06 0.000416843047927529 1 0.999826933785262 1 2 3) Uncertain significance No change no 1 +Isoniazid ahpC c.-77T>A ahpC_c.-77T>A 1 upstream_gene_variant 2726116 0 0 0 0 14 1 20832 27467 0.000671591672263264 0.000367212509754494 0.00112656023057506 0.999963594000291 0.999797175631493 0.999999078280314 0.933333333333333 0.680515433421696 0.998313569758647 NA NA NA 0 0 0.975 NA NA NA NA 2819 5574 False False 18.459005376344 2.80796092158034 777.750664330232 0 0 0.000177061869457058 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 9 1 13365 21312 0.000672947510094212 0.000307759154923187 0.00127707788784856 0.999953080279641 0.999738608085756 0.999998812096234 0.9 0.554983882971804 0.997471421455538 NA NA NA 0 0 0.975 NA NA NA NA 2303 4479 False False 0 0 0 0 0 0 0 14.3515151515151 1.98814481377699 627.199072547492 0 0 0.000275972346901473 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance No change no 1 +Isoniazid ahpC c.-77T>C ahpC_c.-77T>C 1 upstream_gene_variant 2726116 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2848 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2327 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 1 3) Uncertain significance No change no 1 +Isoniazid ahpC c.-77T>G ahpC_c.-77T>G 1 upstream_gene_variant 2726116 1 2 0 2 15 2 20831 27466 0.000719562505996354 0.000402787826414311 0.00118653165660568 0.999927188000582 0.999737003036386 0.999991182007438 0.88235294117647 0.635590837898749 0.985420683159697 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.02104089052957 0.509431264042152 1212 5574 False False 9.88886755316595 2.29908286227051 89.1762711751101 0 0 0.000177070368626196 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 11 2 13363 21311 0.000822491401226259 0.000410653977896139 0.00147118664271154 0.999906160559283 0.999661061221376 0.999988635406343 0.846153846153846 0.545528944323442 0.980793328017471 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.492336767546 0.526267603788886 981 4479 False False 0 0 0 0 0 0 0 8.77127142108807 1.91382626509507 81.6341774283486 0 0 0.000276013645151466 0.999906160559283 0.999661061221376 0.999988635406343 1 3) Uncertain significance No change no 1 +Isoniazid ahpC c.-78C>A ahpC_c.-78C>A 1 upstream_gene_variant 2726115 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC c.-79_-74delCCTTTG ahpC_c.-79_-74delCCTTTG 1 upstream_gene_variant 2726113 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2814 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2298 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC c.-79C>A ahpC_c.-79C>A 1 upstream_gene_variant 2726114 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2792 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2281 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC c.-79C>G ahpC_c.-79C>G 1 upstream_gene_variant 2726114 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC c.-79C>T ahpC_c.-79C>T 1 upstream_gene_variant 2726114 1 8 0 8 0 8 20846 27460 0 0 0.00017694296670111 0.99970875200233 0.999426206431739 0.999874251669172 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.771808536885009 0.0121106507453556 124 5574 False False 0 0 0.771808536885009 0 0 0.00017694296670111 0.99970875200233 0.999426206431739 0.999874251669172 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 0 8 13374 21305 0 0 0.000275786657608973 0.999624642237132 0.999260530264256 0.999837933676441 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.93343997011793 0.0270142859619197 118.5 4479 False False 0 0 0 0 0 0 0 0 0 0.93343997011793 0 0 0.000275786657608973 0.999624642237132 0.999260530264256 0.999837933676441 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC c.-7G>A ahpC_c.-7G>A 1 upstream_gene_variant 2726186 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2798 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid ahpC c.-80A>G ahpC_c.-80A>G 1 upstream_gene_variant 2726113 1 8 0 8 0 8 20846 27460 0 0 0.00017694296670111 0.99970875200233 0.999426206431739 0.999874251669172 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.771808536885009 0.0121106507453556 124 5574 False False 0 0 0.771808536885009 0 0 0.00017694296670111 0.99970875200233 0.999426206431739 0.999874251669172 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 13374 21307 0 0 0.000275786657608973 0.999718481677849 0.999387354605726 0.999896680954833 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.35335561005417 0.0884814409570568 164 4479 False False 0 0 0 0 0 0 0 0 0 1.35335561005417 0 0 0.000275786657608973 0.999718481677849 0.999387354605726 0.999896680954833 1 3) Uncertain significance No change no 1 +Isoniazid ahpC c.-81_-74delCACCTTTG ahpC_c.-81_-74delCACCTTTG 1 upstream_gene_variant 2726111 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2793 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC c.-81C>A ahpC_c.-81C>A 1 upstream_gene_variant 2726112 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC c.-81C>T ahpC_c.-81C>T 1 upstream_gene_variant 2726112 1 2 0 2 52 6 20794 27462 0.00249448335412069 0.00186354348115391 0.0032699122495068 0.999781564001747 0.999524617886493 0.999919833755107 0.896551724137931 0.788313542201202 0.961079168077635 0 0 0.841886116991581 0 0 0.4592581264399 0 0 7.03250982177651 0.509541588656181 1215 5574 False False 11.4458016735596 4.91664123408017 32.6463386314214 0 0 0.000177385412510268 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 43 6 13331 21307 0.00321519365933901 0.0023277991690822 0.00432842794483404 0.999718481677849 0.999387354605726 0.999896680954833 0.877551020408163 0.752307031640317 0.953710968918104 0 0 0.841886116991581 0 0 0.4592581264399 0 0 8.51112478327309 0.526508088674695 987 4479 False False 0 0 0 0 0 0 0 11.454517040482 4.85236772353917 32.9683852927977 0 0 0.000276676102181712 0.999718481677849 0.999387354605726 0.999896680954833 2 3) Uncertain significance No change no 1 +Isoniazid ahpC c.-83A>C ahpC_c.-83A>C 1 upstream_gene_variant 2726110 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid ahpC c.-83A>G ahpC_c.-83A>G 1 upstream_gene_variant 2726110 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC c.84C>G ahpC_c.84C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.-84T>C ahpC_c.-84T>C 1 upstream_gene_variant 2726109 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC c.-86T>G ahpC_c.-86T>G 1 upstream_gene_variant 2726107 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2787 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2277 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC c.-87A>G ahpC_c.-87A>G 1 upstream_gene_variant 2726106 1 5 0 5 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.43785249906968 0.0743380732312645 251 5574 False False 0 0 1.43785249906968 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 13374 21308 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.73894646374006 0.163960020972012 248.5 4479 False False 0 0 0 0 0 0 0 0 0 1.73894646374006 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC c.-88_-86delGATinsA ahpC_c.-88_-86delGATinsA 1 upstream_gene_variant 2726105 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2828 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2311 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC c.-88_-87insAT ahpC_c.-88_-87insAT 1 upstream_gene_variant 2726105 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2834 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2315 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC c.-88G>A ahpC_c.-88G>A 1 upstream_gene_variant 2726105 1 54 11 43 1472 3925 19374 23543 0.0706130672551089 0.0671715561826258 0.0741748914387292 0.857106451143148 0.852911839264322 0.86122537203253 0.272744117102093 0.260894811183874 0.284839614778702 0.203703703703703 0.106319252490214 0.335304919489249 0.00279471544715447 0.00139591184813941 0.00499500333305933 0.310861355784904 0.144512006414054 0.61324111802526 0.000181948499136823 NA NA False True 0.455733187626203 0.427698261607658 0.485441482875443 0.000567449058550425 0.000283301476270552 0.00101509574706255 0.857106451143148 0.852911839264322 0.86122537203253 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 52 9 43 974 3214 12400 18099 0.072827874981307 0.0684797992547368 0.0773628949702005 0.849200018767888 0.844324656336973 0.853979931855712 0.232569245463228 0.219844869038175 0.245667687491121 0.173076923076923 0.0823256854420928 0.303280106103133 0.00279242941358982 0.00127764691141273 0.00529425357241288 0.305496999249812 0.130892445864485 0.635673224309581 0.000550615204837463 NA NA False True 0 1 1 0 0 1 1 0.442329576249071 0.409850816129801 0.477097381251332 0.000725280038681602 0.00033169614339037 0.00137635894312966 0.849200018767888 0.844324656336973 0.853979931855712 653 Not assoc w R 5) Not assoc w R No change yes 1 +Isoniazid ahpC c.-88G>C ahpC_c.-88G>C 1 upstream_gene_variant 2726105 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2836 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2317 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC c.-89T>A ahpC_c.-89T>A 1 upstream_gene_variant 2726104 0 0 0 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2837 5574 False False Inf 0.869878292971449 Inf 0 0 0.000176976922618654 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 0 13370 21313 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 1 0.999826933785262 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2318 4479 False False 0 0 0 0 0 0 0 Inf 1.05210128917758 Inf 0 0 0.000275869155324334 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC c.-89T>G ahpC_c.-89T>G 1 upstream_gene_variant 2726104 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 2 3) Uncertain significance No change no 1 +Isoniazid ahpC c.-90_-81delGTGATATATCinsA ahpC_c.-90_-81delGTGATATATCinsA 1 upstream_gene_variant 2726103 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2825 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2309 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC c.-90G>A ahpC_c.-90G>A 1 upstream_gene_variant 2726103 1 6 0 6 10 6 20836 27462 0.000479708337330902 0.000230061997553563 0.000882023176671562 0.999781564001747 0.999524617886493 0.999919833755107 0.625 0.354346094302078 0.848016324918877 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.11954627059257 0.0402423456259031 219 5574 False False 2.19667882511038 0.723214951988028 7.35513174249784 0 0 0.000177027880937939 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 9 4 13365 21309 0.000672947510094212 0.000307759154923187 0.00127707788784856 0.999812321118566 0.999519537882235 0.999948861529775 0.692307692307692 0.385738338249294 0.909079605427903 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.41583126108955 0.305446426672107 419 4479 False False 0 0 0 0 0 0 0 3.58737373737373 1.00094889844823 15.9392662427084 0 0 0.000275972346901473 0.999812321118566 0.999519537882235 0.999948861529775 1 3) Uncertain significance No change no 1 +Isoniazid ahpC c.-90G>C ahpC_c.-90G>C 1 upstream_gene_variant 2726103 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid ahpC c.-93_-92insGT ahpC_c.-93_-92insGT 1 upstream_gene_variant 2726100 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2816 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2300 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC c.-93G>A ahpC_c.-93G>A 1 upstream_gene_variant 2726100 0 0 0 0 2 2 20844 27466 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999927188000582 0.999737003036386 0.999991182007438 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2815 5574 False False 1.3176933410094 0.0955278435529395 18.1762534351792 0 0 0.000176959943030976 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 2 13372 21311 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999906160559283 0.999661061221376 0.999988635406343 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2299 4479 False False 0 0 0 0 0 0 0 1.59370326054442 0.115491055908661 21.9865025501046 0 0 0.000275827900298067 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC c.-93G>C ahpC_c.-93G>C 1 upstream_gene_variant 2726100 1 3 1 2 2 2 20844 27466 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999927188000582 0.999737003036386 0.999991182007438 0.5 0.067585986488543 0.932414013511457 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.658846670504701 0.0111723913611586 12.657347321213 1 2027.5 5574 False False 1.3176933410094 0.0955278435529395 18.1762534351792 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC c.-93G>T ahpC_c.-93G>T 1 upstream_gene_variant 2726100 0 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2810 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2295 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC c.96C>T ahpC_c.96C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC c.9G>A ahpC_c.9G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ahpC deletion ahpC_deletion 1 feature_ablation (see "Genomic_coordinates" sheet) 1 1 0 1 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 51.3428199661809 1 2027.5 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2306 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC LoF ahpC_LoF 1 LoF (see "Genomic_coordinates" sheet) 1 16 1 15 7 18 20839 27450 0.000335795836131632 0.000135017659185429 0.000691744589626827 0.999344692005242 0.998964527817385 0.999611578174657 0.28 0.120716688504066 0.493876821806255 0.0625 0.00158111172276588 0.302320738434531 0.0526315789473684 0.00133162880417942 0.260280654195214 0.0878161140169873 0.00209019122764457 0.570897359045527 0.00189673142406102 89 5574 False False 0.512260665099093 0.180805081530838 1.28565953961729 4.79846449136276e-05 1.21486528816812e-06 0.000267324007069132 0.999344692005242 0.998964527817385 0.999611578174657 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 13 1 12 7 15 13367 21298 0.000523403618962165 0.000210460468745924 0.00107811225334149 0.999296204194623 0.998839461100611 0.999606039023746 0.318181818181818 0.138646521553797 0.54872442757377 0.0769230769230769 0.00194562849734675 0.360297435267877 0.0625 0.00158111172276588 0.302320738434531 0.132777237475374 0.00310998675438209 0.897652994735548 0.0220128626195996 112 4479 False False 0 0 0 0 0 0 0 0.743552529862098 0.256398485012867 1.93801205554908 7.48055056852184e-05 1.89390963565694e-06 0.000416718340634631 0.999296204194623 0.998839461100611 0.999606039023746 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC p.Ala122Thr ahpC_p.Ala122Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2829 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Ala12Val ahpC_p.Ala12Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Ala149Asp ahpC_p.Ala149Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC p.Ala149Thr ahpC_p.Ala149Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Ala151Ser ahpC_p.Ala151Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Ala193Val ahpC_p.Ala193Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Ala195Thr ahpC_p.Ala195Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2806 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2293 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC p.Arg133Gln ahpC_p.Arg133Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Arg133His ahpC_p.Arg133His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2809 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2294 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC p.Arg163fs ahpC_p.Arg163fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2788 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2278 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC p.Arg163* ahpC_p.Arg163* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Arg179His ahpC_p.Arg179His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Asn72fs ahpC_p.Asn72fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC p.Asn72Lys ahpC_p.Asn72Lys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2841 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2321 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC p.Asp102Glu ahpC_p.Asp102Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC p.Asp102Gly ahpC_p.Asp102Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC p.Asp113Gly ahpC_p.Asp113Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2817 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2301 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC p.Asp166Asn ahpC_p.Asp166Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC p.Asp171Asn ahpC_p.Asp171Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Asp182Gly ahpC_p.Asp182Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Asp186Glu ahpC_p.Asp186Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Asp22Asn ahpC_p.Asp22Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Asp22Glu ahpC_p.Asp22Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2842 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC p.Asp33Ala ahpC_p.Asp33Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 1 0.025 1 0.25 0.00630946320970987 0.805879550316756 Inf 0.0337822672686709 Inf 0.43149593260334 829 5574 False False 0.439194051331254 0.00837049629364692 5.4704842261679 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 3 13373 21310 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999859240838924 0.999588697652472 0.999970971136275 0.25 0.00630946320970987 0.805879550316756 1 0.025 1 0.25 0.00630946320970987 0.805879550316756 Inf 0.0408559380567331 Inf 0.385595663706608 668 4479 False False 0 0 0 0 0 0 0 0.531169769934445 0.010122018243966 6.61631049307563 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Asp41Asn ahpC_p.Asp41Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Asp73Gly ahpC_p.Asp73Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2800 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2287 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Asp73His ahpC_p.Asp73His 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 3 3 71 3 20775 27465 0.00340592919504941 0.00266098821822608 0.00429420306078129 0.999890782000873 0.99968085216583 0.999977476056514 0.959459459459459 0.886062743253437 0.991560243629235 0.5 0.118117248757025 0.881882751242974 0.5 0.118117248757025 0.881882751242974 1.32202166064981 0.177047020708512 9.86929690556506 1 2027.5 5574 False False 31.2878459687123 10.2777249605025 155.52980174376 0.000144383482529598 2.97763350102176e-05 0.000421891250052717 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 2 2 25 2 13349 21311 0.00186929863915059 0.00121006548869323 0.00275822519578355 0.999906160559283 0.999661061221376 0.999988635406343 0.925925925925926 0.757101653154372 0.990899927057693 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 1.59644917222263 0.11569006393826 22.02440649909 0.641897890537327 992 4479 False False 0 0 0 0 0 0 0 19.9556146527829 4.97431729497115 173.578167878985 0.000149801512995281 1.81421730736357e-05 0.000541028700199687 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Asp77fs ahpC_p.Asp77fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Asp79Asn ahpC_p.Asp79Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Asp8fs ahpC_p.Asp8fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC p.Cys61Trp ahpC_p.Cys61Trp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2840 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2320 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC p.Gln145Pro ahpC_p.Gln145Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2845 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2324 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Gln169His ahpC_p.Gln169His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC p.Glu143Ala ahpC_p.Glu143Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2789 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2279 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC p.Glu160Lys ahpC_p.Glu160Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Glu76Lys ahpC_p.Glu76Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 43 4 39 26 44 20820 27424 0.00124724167706034 0.000814896390023582 0.00182696777478964 0.998398136012814 0.997850162306153 0.998835849366048 0.371428571428571 0.258869804492268 0.495234137356686 0.0930232558139534 0.0259312902663234 0.221353445381386 0.0833333333333333 0.023173495136761 0.19982801419938 0.135096923569546 0.0350884244885808 0.374551466489425 1.64893247484787e-06 36 5574 True False 0.77834250283818 0.459923219454355 1.29277029863227 0.000192086054552439 5.23393854651941e-05 0.000491742888229089 0.998398136012814 0.997850162306153 0.998835849366048 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 22 1 21 10 24 13364 21289 0.000747719455660236 0.000358616922835118 0.00137465137870696 0.998873926711396 0.998324952535764 0.99927837451873 0.294117647058823 0.150983664423028 0.474781060340485 0.0454545454545454 0.00115014752657357 0.228444397667633 0.04 0.00101219969931084 0.203516913922414 0.0758576702156468 0.0018383977749669 0.471795975360514 0.000581233003820975 51 4479 False False 0 0 0 0 0 0 0 0.66375461438691 0.283207752368125 1.44059464050761 7.48222970445192e-05 1.89433475526229e-06 0.000416811864107337 0.998873926711396 0.998324952535764 0.99927837451873 15 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Gly155Glu ahpC_p.Gly155Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC p.Gly188Ala ahpC_p.Gly188Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC p.Gly20Ala ahpC_p.Gly20Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Gly21Ser ahpC_p.Gly21Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Gly32Asp ahpC_p.Gly32Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2846 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2325 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Gly32Ser ahpC_p.Gly32Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2850 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Gly45Ala ahpC_p.Gly45Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2826 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2310 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Gly45Ser ahpC_p.Gly45Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC p.His100Leu ahpC_p.His100Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC p.His43Gln ahpC_p.His43Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC p.His93Arg ahpC_p.His93Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC p.Ile137Thr ahpC_p.Ile137Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Leu106fs ahpC_p.Leu106fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC p.Leu106Phe ahpC_p.Leu106Phe 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2820 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2304 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC p.Leu111Ala ahpC_p.Leu111Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2847 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2326 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC p.Leu15Arg ahpC_p.Leu15Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Leu15Ile ahpC_p.Leu15Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC p.Leu162Gln ahpC_p.Leu162Gln 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2823 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2307 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC p.Leu165Phe ahpC_p.Leu165Phe 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2802 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2289 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Leu168fs ahpC_p.Leu168fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Leu185Ile ahpC_p.Leu185Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC p.Leu190fs ahpC_p.Leu190fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2799 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2286 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC p.Leu191Arg ahpC_p.Leu191Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Leu191Phe ahpC_p.Leu191Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 36 2 34 11 42 20835 27426 0.000527679171063993 0.000263444034397523 0.000943967185544106 0.998470948012232 0.997933721766724 0.99889777846355 0.20754716981132 0.108422823285952 0.341071366949267 0.0555555555555555 0.00680030065402281 0.186636706457554 0.0454545454545454 0.00555295199537049 0.154731577658989 0.0774319230932113 0.00900548282215031 0.302120505130353 6.97513992712095e-07 33 5574 True False 0.344756419486441 0.160040819213685 0.681578758904388 9.59831069731727e-05 1.1624210921735e-05 0.00034668051841439 0.998470948012232 0.997933721766724 0.99889777846355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 19 2 17 8 20 13366 21293 0.000598175564528189 0.000258283997825234 0.00117830226263269 0.99906160559283 0.998551096167295 0.999426713067202 0.285714285714285 0.132236512571125 0.48666831544894 0.105263157894736 0.0130121643717774 0.331376664456765 0.0909090909090909 0.0112055860241509 0.291612741553933 0.187420232195826 0.0210017210603158 0.789776317578166 0.0157649469260873 109 4479 False False 0 0 0 0 0 0 0 0.637228789465808 0.242674494909234 1.51087183772408 0.000149611011370436 1.81191011343365e-05 0.000540340811917895 0.99906160559283 0.998551096167295 0.999426713067202 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Leu191Pro ahpC_p.Leu191Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2804 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2291 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC p.Leu4Arg ahpC_p.Leu4Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Leu71fs ahpC_p.Leu71fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2796 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2284 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC p.Lys115Arg ahpC_p.Lys115Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Lys180Asn ahpC_p.Lys180Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Lys192Gln ahpC_p.Lys192Gln 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2838 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2319 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Lys29Asn ahpC_p.Lys29Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC p.Lys29fs ahpC_p.Lys29fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2812 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2296 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Met1? ahpC_p.Met1? 1 start_lost (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Phe108Val ahpC_p.Phe108Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2821 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Phe52Ser ahpC_p.Phe52Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2822 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2305 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Pro109fs ahpC_p.Pro109fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Pro44Arg ahpC_p.Pro44Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 57 1 56 62 60 20784 27408 0.00297419169145159 0.00228103289080476 0.00381118014718562 0.997815640017474 0.997189177943378 0.998332701985705 0.508196721311475 0.416153634124732 0.599832640892608 0.0175438596491228 0.000444073440089392 0.0939168418919107 0.0163934426229508 0.00041495991283974 0.0879881229227452 0.0235483338832068 0.000590531522573782 0.136718074649618 7.76560679005703e-13 13 5574 True False 1.3626635873749 0.939508382591277 1.97762197062836 4.81116189559778e-05 1.21807998868073e-06 0.000268031305769085 0.997815640017474 0.997189177943378 0.998332701985705 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 41 1 40 38 44 13336 21269 0.00284133393150889 0.00201145765808948 0.00389788786095172 0.997935532304227 0.997229528416783 0.99849956619829 0.463414634146341 0.352530948438872 0.577018491029475 0.024390243902439 0.000617316893286519 0.128554020384146 0.0222222222222222 0.000562459715402258 0.117704331418294 0.039871400719856 0.000989469520838195 0.235342071747659 1.05011400622655e-07 14 4479 True False 0 0 0 0 0 0 0 1.37737566123139 0.867820785666968 2.17690679163241 7.49793806703156e-05 1.89831176079597e-06 0.000417686778406253 0.997935532304227 0.997229528416783 0.99849956619829 6 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Pro62His ahpC_p.Pro62His 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2790 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2280 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Ser119Asn ahpC_p.Ser119Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2824 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2308 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC p.Ser194Leu ahpC_p.Ser194Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2794 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2282 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC p.Ter196ext*? ahpC_p.Ter196ext*? 1 stop_lost (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2852 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Thr105Lys ahpC_p.Thr105Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Thr105Met ahpC_p.Thr105Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01632529799099 0.509386028876591 1135.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48598624162872 0.526186417038858 925 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Thr150Ala ahpC_p.Thr150Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC p.Thr5Ile ahpC_p.Thr5Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 1 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Thr63Asn ahpC_p.Thr63Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC p.Trp178Cys ahpC_p.Trp178Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC p.Trp178fs ahpC_p.Trp178fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC p.Trp96Arg ahpC_p.Trp96Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2827 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Trp96Cys ahpC_p.Trp96Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Tyr34Cys ahpC_p.Tyr34Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 20 0 20 0 21 20846 27447 0 0 0.00017694296670111 0.999235474006116 0.998831576963824 0.999526686034611 0 0 0.161097615219079 0 0 0.168433470983085 0 0 0.161097615219079 0 0 0.266725714062677 1.37688359223306e-05 46.5 5574 True False 0 0 0.252885886770404 0 0 0.00017694296670111 0.999235474006116 0.998831576963824 0.999526686034611 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 13 0 13 0 13 13374 21300 0 0 0.000275786657608973 0.99939004363534 0.998957181904114 0.999675185224884 0 0 0.24705263800047 0 0 0.24705263800047 0 0 0.24705263800047 0 0 0.522684266329562 0.00268949884736775 60 4479 False False 0 0 0 0 0 0 0 0 0 0.522684266329562 0 0 0.000275786657608973 0.99939004363534 0.998957181904114 0.999675185224884 4 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Val130Met ahpC_p.Val130Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 3 2 20843 27466 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999927188000582 0.999737003036386 0.999991182007438 0.6 0.146632799634673 0.947255049473683 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01699856622015 0.509392482788101 1176.5 5574 False False 1.97663484143357 0.226402568392661 23.6672561646805 0 0 0.00017696843241753 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48598624162872 0.526186417038858 925 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Val134Leu ahpC_p.Val134Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC p.Val138fs ahpC_p.Val138fs 1 frameshift (see "Genomic_coordinates" sheet) 1 3 1 2 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.658815063564403 0.011171855707321 12.6567401482543 1 2027.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.796792043670081 0.0135099696349484 15.307558728263 1 1642.5 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Val147Gly ahpC_p.Val147Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC p.Val158Phe ahpC_p.Val158Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Val161Gly ahpC_p.Val161Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2808 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Val161Ile ahpC_p.Val161Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2795 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2283 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Val161Leu ahpC_p.Val161Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Val49fs ahpC_p.Val49fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2831 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC p.Val49Leu ahpC_p.Val49Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2818 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2302 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ahpC p.Val85fs ahpC_p.Val85fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid ahpC p.Val85Ile ahpC_p.Val85Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2835 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2316 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.1005G>A dnaA_c.1005G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1008G>A dnaA_c.1008G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.102T>C dnaA_c.102T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-104A>C dnaA_c.-104A>C 2 upstream_gene_variant 4411429 1 2 1 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.31767810026385 0.0167927522337569 103.35711725526 1 1253.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.59365886487699 0.0203005577541163 124.983813232444 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-104A>G dnaA_c.-104A>G 2 upstream_gene_variant 4411429 1 0 0 0 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 5002 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4015 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.1053C>G dnaA_c.1053C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1053C>T dnaA_c.1053C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 5 21 20841 27447 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.999235474006116 0.998831576963824 0.999526686034611 0.192307692307692 0.0655481087367825 0.393505527939321 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.313564608224173 0.092365223539415 0.854685525437007 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 16 13372 21297 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999249284474264 0.998781170540482 0.999570842259671 0.111111111111111 0.0137512156643644 0.347120438608672 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.199082037092431 0.0222040265100065 0.847018753536956 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1056G>C dnaA_c.1056G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1062C>G dnaA_c.1062C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1065C>T dnaA_c.1065C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1074C>T dnaA_c.1074C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1086C>T dnaA_c.1086C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.108C>A dnaA_c.108C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 19 20845 27449 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999308286005533 0.998920012739518 0.999583493240977 0.05 0.0012650894979498 0.248732762772027 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.0693060307280554 0.0016722324841301 0.436038420017075 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 17 13373 21296 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999202364753906 0.998723214865585 0.999535281595187 0.0555555555555555 0.00140555616736942 0.272943599673368 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.0936742602522202 0.00224547098341481 0.5980024962562 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.108C>T dnaA_c.108C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 6 3 20840 27465 0.000287825002398541 0.000105633792978048 0.000626367784710498 0.999890782000873 0.99968085216583 0.999977476056514 0.666666666666666 0.29929505620854 0.925145368580308 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.63579654510556 0.562830574439234 16.2901193363597 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 6 1 13368 21312 0.000448631673396141 0.000164657143425453 0.000976224581517196 0.999953080279641 0.999738608085756 0.999998812096234 0.857142857142857 0.421276802956804 0.996389703138099 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 9.56552962298025 1.16026312817987 439.068355223953 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-108G>A dnaA_c.-108G>A 2 upstream_gene_variant 4411425 NA 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4882 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3915 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-108G>T dnaA_c.-108G>T 2 upstream_gene_variant 4411425 1 2 0 2 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 7.01606985634675 0.509383580255417 1109.5 5574 False False 0.439194051331254 0.00837049629364692 5.4704842261679 0 0 0.000176951454458875 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48598624162872 0.526186417038858 925 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.1092T>C dnaA_c.1092T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1095C>T dnaA_c.1095C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-110_-109insTG dnaA_c.-110_-109insTG 2 upstream_gene_variant 4411423 NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4901 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.1101C>T dnaA_c.1101C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-110C>A dnaA_c.-110C>A 2 upstream_gene_variant 4411423 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-111A>C dnaA_c.-111A>C 2 upstream_gene_variant 4411422 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5030 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-111A>G dnaA_c.-111A>G 2 upstream_gene_variant 4411422 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4940 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.1122C>A dnaA_c.1122C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.99604811372315 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.41420404242617 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1125G>A dnaA_c.1125G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.43785249906968 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.41420404242617 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1126C>T dnaA_c.1126C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 27 38 20819 27430 0.00129521251079343 0.000853721301750774 0.00188391092655412 0.998616572011067 0.998101626446224 0.999020823782757 0.415384615384615 0.294381998249767 0.54435531399243 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.936151440612193 0.549455358986962 1.57469937590283 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 24 30 13350 21283 0.00179452669358456 0.00115011499978073 0.00266894436176925 0.998592408389246 0.997991180201286 0.999050108601822 0.444444444444444 0.309196474387757 0.58599967196308 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.27538576779026 0.7132301839785 2.25749824288331 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-112T>A dnaA_c.-112T>A 2 upstream_gene_variant 4411421 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4913 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3940 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.1131C>A dnaA_c.1131C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 118 45 20728 27423 0.00566055838050465 0.0046875697589468 0.00677503755506037 0.998361730013106 0.997808473060249 0.998804791378681 0.723926380368098 0.648554639125849 0.790962388968715 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.46918178309533 2.43999515440494 5.00847992481503 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 111 39 13263 21274 0.00829968595782862 0.00683245755945316 0.00998647834964594 0.998170130906019 0.997499348916974 0.998698470574285 0.74 0.662143279347338 0.808124182233042 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.56526252907162 3.14089715961268 6.76087687622416 NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1132C>A dnaA_c.1132C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1137C>T dnaA_c.1137C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-113G>A dnaA_c.-113G>A 2 upstream_gene_variant 4411420 1 10 0 10 7 10 20839 27458 0.000335795836131632 0.000135017659185429 0.000691744589626827 0.999635940002912 0.999330582956894 0.999825405716755 0.411764705882352 0.184436961783946 0.670752846053242 0 0 0.30849710781876 0 0 0.30849710781876 0 0 0.58792320730481 0.00669312143814019 115 5574 False False 0.922337924084649 0.297924233707181 2.68486556735384 0 0 0.00017700239811062 0.999635940002912 0.999330582956894 0.999825405716755 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 5 10 13369 21303 0.000373859727830118 0.000121402023062639 0.000872246401868143 0.999530802796415 0.99913729947772 0.999774979505452 0.333333333333333 0.11824110336688 0.616196267458845 0 0 0.30849710781876 0 0 0.30849710781876 0 0 0.711031546821633 0.00889995476297841 79 4479 False False 0 0 0 0 0 0 0 0.796731243922507 0.213632108508685 2.55899230094854 0 0 0.000275889787465637 0.999530802796415 0.99913729947772 0.999774979505452 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-113G>T dnaA_c.-113G>T 2 upstream_gene_variant 4411420 NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5003 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4016 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.1143G>A dnaA_c.1143G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.658815063564403 0.011171855707321 12.6567401482543 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1149C>G dnaA_c.1149C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-114G>A dnaA_c.-114G>A 2 upstream_gene_variant 4411419 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.114T>C dnaA_c.114T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1155G>A dnaA_c.1155G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-115C>A dnaA_c.-115C>A 2 upstream_gene_variant 4411418 1 6 0 6 1 11 20845 27457 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999599534003203 0.9992835689522 0.999800072407065 0.0833333333333333 0.00210759323186022 0.384796165150944 0 0 0.4592581264399 0 0 0.284914152918154 0 0 1.11885918050138 0.0402021672928921 180 5574 False False 0.119745306264855 0.00278612189885952 0.824021419435307 0 0 0.000176951454458875 0.999599534003203 0.9992835689522 0.999800072407065 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 1 9 13373 21304 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999577722516773 0.999198537836033 0.999806890245066 0.1 0.00252857854446178 0.445016117028195 0 0 0.4592581264399 0 0 0.336267116879942 0 0 1.35326630722375 0.088479592431554 155.5 4479 False False 0 0 0 0 0 0 0 0.177006738286929 0.00404223590282617 1.27765801502961 0 0 0.000275807277411719 0.999577722516773 0.999198537836033 0.999806890245066 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.1167A>G dnaA_c.1167A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1167A>T dnaA_c.1167A>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-116A>C dnaA_c.-116A>C 2 upstream_gene_variant 4411417 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-116A>G dnaA_c.-116A>G 2 upstream_gene_variant 4411417 1 4 0 4 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 1.99604811372315 0.139118032244638 322.5 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.1179G>T dnaA_c.1179G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.117G>A dnaA_c.117G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.18865318395302 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-117G>A dnaA_c.-117G>A 2 upstream_gene_variant 4411416 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.1180C>T dnaA_c.1180C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1182G>A dnaA_c.1182G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 2 20844 27466 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999927188000582 0.999737003036386 0.999991182007438 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.3176933410094 0.0955278435529395 18.1762534351792 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1182G>C dnaA_c.1182G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1185C>G dnaA_c.1185C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1197T>C dnaA_c.1197T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-11G>A dnaA_c.-11G>A 2 upstream_gene_variant 4411522 1 2 0 2 3 2 20843 27466 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999927188000582 0.999737003036386 0.999991182007438 0.6 0.146632799634673 0.947255049473683 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01699856622015 0.509392482788101 1176.5 5574 False False 1.97663484143357 0.226402568392661 23.6672561646805 0 0 0.00017696843241753 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48598624162872 0.526186417038858 925 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.1206G>A dnaA_c.1206G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.658815063564403 0.011171855707321 12.6567401482543 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1206G>C dnaA_c.1206G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1209C>A dnaA_c.1209C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1209C>T dnaA_c.1209C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.120G>A dnaA_c.120G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1218C>T dnaA_c.1218C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-121T>G dnaA_c.-121T>G 2 upstream_gene_variant 4411412 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4837 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3874 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.1224C>T dnaA_c.1224C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.247471899512553 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.123C>G dnaA_c.123C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-123G>A dnaA_c.-123G>A 2 upstream_gene_variant 4411410 1 1 0 1 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 51.3428199661809 1 2027.5 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 62.0829055149378 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.1245G>A dnaA_c.1245G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.18865318395302 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1245G>C dnaA_c.1245G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.658815063564403 0.011171855707321 12.6567401482543 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-124G>A dnaA_c.-124G>A 2 upstream_gene_variant 4411409 1 3 0 3 1 4 20845 27464 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999854376001165 0.999627187086024 0.999960320981843 0.2 0.00505076337946806 0.716417936118089 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.18869006320801 0.264075370383126 529 5574 False False 0.329383545214679 0.00669260119676484 3.32889360843958 0 0 0.000176951454458875 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-124G>C dnaA_c.-124G>C 2 upstream_gene_variant 4411409 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.1260C>A dnaA_c.1260C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1263C>A dnaA_c.1263C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-126C>T dnaA_c.-126C>T 2 upstream_gene_variant 4411407 1 1 0 1 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 51.3446878573018 1 2027.5 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 62.0858160113928 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.126T>C dnaA_c.126T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1272C>T dnaA_c.1272C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 12 20845 27456 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999563128003495 0.99923699702714 0.999774242139628 0.0769230769230769 0.00194562849734675 0.360297435267877 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.10976253298153 0.00257183264698232 0.742010663012835 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 11 13373 21302 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999483883076056 0.999076712346733 0.999742329032819 0.0833333333333333 0.00210759323186022 0.384796165150944 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.144810099046246 0.00336819644582784 0.996572767671761 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1284C>A dnaA_c.1284C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 9 5 20837 27463 0.000431737503597812 0.000197436276106449 0.000819413341228355 0.999817970001456 0.999575254267103 0.999940892797913 0.642857142857142 0.351380110615991 0.87240157014084 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.37238566012381 0.713840715368813 9.0134596352925 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 8 1 13366 21312 0.000598175564528189 0.000258283997825234 0.00117830226263269 0.999953080279641 0.999738608085756 0.999998812096234 0.888888888888888 0.517503485082663 0.9971908632534 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 12.7559479275774 1.70975577844451 564.516212294525 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-128G>A dnaA_c.-128G>A 2 upstream_gene_variant 4411405 1 4 0 4 5 9 20841 27459 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.999672346002621 0.99937810218515 0.999850165132458 0.357142857142857 0.127598429859159 0.648619889384008 0 0 0.602364635616474 0 0 0.336267116879942 0 0 1.9961634006832 0.139123899833994 346 5574 False False 0.731970634806391 0.192681152309073 2.43252804051037 0 0 0.000176985413634466 0.999672346002621 0.99937810218515 0.999850165132458 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 5 7 13369 21306 0.000373859727830118 0.000121402023062639 0.000872246401868143 0.99967156195749 0.999323409938814 0.999867941002665 0.416666666666666 0.15165222980843 0.723330314317894 0 0 0.707598226178713 0 0 0.409616397225003 0 0 3.8572367987261 0.289297756032672 404 4479 False False 0 0 0 0 0 0 0 1.13834777683981 0.2848263848123 4.16756074389191 0 0 0.000275889787465637 0.99967156195749 0.999323409938814 0.999867941002665 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-128G>C dnaA_c.-128G>C 2 upstream_gene_variant 4411405 1 10 0 10 8 11 20838 27457 0.000383766669864722 0.000165697303700768 0.000756032532322191 0.999599534003203 0.9992835689522 0.999800072407065 0.421052631578947 0.202521438977162 0.665002155988264 0 0 0.30849710781876 0 0 0.284914152918154 0 0 0.587930014520783 0.00669312341205301 116 5574 False False 0.958284253418143 0.334561191295881 2.61630507790885 0 0 0.000177010891571197 0.999599534003203 0.9992835689522 0.999800072407065 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 7 10 13367 21303 0.000523403618962165 0.000210460468745924 0.00107811225334149 0.999530802796415 0.99913729947772 0.999774979505452 0.411764705882352 0.184436961783946 0.670752846053242 0 0 0.336267116879942 0 0 0.30849710781876 0 0 0.807586740948959 0.0153745168609506 104 4479 False False 0 0 0 0 0 0 0 1.11559063365003 0.360321785456606 3.24783243840935 0 0 0.000275931061008045 0.999530802796415 0.99913729947772 0.999774979505452 2 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.1296C>A dnaA_c.1296C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1296C>G dnaA_c.1296C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1296C>T dnaA_c.1296C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1299G>C dnaA_c.1299G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-129C>A dnaA_c.-129C>A 2 upstream_gene_variant 4411404 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.1302C>A dnaA_c.1302C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 154 640 20692 26828 0.0073875083948959 0.0062701843283896 0.00864531369217658 0.976700160186398 0.974846726388694 0.978451786834765 0.193954659949622 0.167000430074806 0.22320280411306 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.311979871447902 0.259687324999585 0.372938965806763 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 137 604 13237 20709 0.0102437565425452 0.0086070760184135 0.0120984755524485 0.971660488903486 0.969343858211453 0.973847245657524 0.184885290148448 0.157558768454444 0.214746242726551 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 0 0.354856845676903 0.292204973799289 0.428444039519113 NA NA NA NA NA NA 23 5) Not assoc w R Now listed Silent mutation no 0 +Isoniazid dnaA c.1302C>T dnaA_c.1302C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 5 1 20841 27467 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.999963594000291 0.999797175631493 0.999999078280314 0.833333333333333 0.358765421002325 0.99578925548551 NA NA NA NA NA NA NA NA NA NA NA NA False False 6.58965500695744 0.737267067818355 311.215258952954 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 5 1 13369 21312 0.000373859727830118 0.000121402023062639 0.000872246401868143 0.999953080279641 0.999738608085756 0.999998812096234 0.833333333333333 0.358765421002325 0.99578925548551 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 7.97067843518587 0.891722638077622 376.304140424995 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1311C>T dnaA_c.1311C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1323C>T dnaA_c.1323C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1326G>A dnaA_c.1326G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1332A>C dnaA_c.1332A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 5 0 20841 27468 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 1 0.999865711673152 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.20760984683633 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-133G>A dnaA_c.-133G>A 2 upstream_gene_variant 4411400 1 0 0 0 0 8 20846 27460 0 0 0.00017694296670111 0.99970875200233 0.999426206431739 0.999874251669172 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 4813 5574 False False 0 0 0.771808536885009 0 0 0.00017694296670111 0.99970875200233 0.999426206431739 0.999874251669172 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 8 13374 21305 0 0 0.000275786657608973 0.999624642237132 0.999260530264256 0.999837933676441 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 3855 4479 False False 0 0 0 0 0 0 0 0 0 0.93343997011793 0 0 0.000275786657608973 0.999624642237132 0.999260530264256 0.999837933676441 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-133G>T dnaA_c.-133G>T 2 upstream_gene_variant 4411400 NA 0 0 0 203 751 20643 26717 0.00973807924781732 0.00844975734322504 0.0111657463221822 0.972659094218727 0.970661665734808 0.974555678517927 0.212788259958071 0.187211767579328 0.240150896188393 NA NA NA 0 0 0.00489991273196209 NA NA NA NA 4807 5574 False True 0.349841219958107 0.297801157246779 0.409534738332232 0 0 0.000178682840409287 0.972659094218727 0.970661665734808 0.974555678517927 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 116 572 13258 20741 0.00867354568565874 0.00717226296933814 0.0103940817199075 0.973161919954957 0.970903180904634 0.975290324112411 0.16860465116279 0.141371503142867 0.198714630322763 NA NA NA 0 0 0.00642833920590076 NA NA NA NA 3849 4479 False True 0 1 1 0 0 0 0 0.317258770796257 0.257288180130197 0.388474791542665 0 0 0.000278199299176308 0.973161919954957 0.970903180904634 0.975290324112411 162 5) Not assoc w R New NotAwR yes 5 +Isoniazid dnaA c.1341G>A dnaA_c.1341G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1348C>T dnaA_c.1348C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 7 20845 27461 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999745158002038 0.999474999027776 0.999897534357495 0.125 0.0031597235312519 0.526509670875206 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.188198608779083 0.00417990056987037 1.46513319151887 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.41420404242617 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1350G>C dnaA_c.1350G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1350G>T dnaA_c.1350G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1356T>C dnaA_c.1356T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 5 1 20841 27467 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.999963594000291 0.999797175631493 0.999999078280314 0.833333333333333 0.358765421002325 0.99578925548551 NA NA NA NA NA NA NA NA NA NA NA NA False False 6.58965500695744 0.737267067818355 311.215258952954 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1359G>A dnaA_c.1359G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1362C>G dnaA_c.1362C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1374G>T dnaA_c.1374G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1377G>A dnaA_c.1377G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1380C>G dnaA_c.1380C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1380C>T dnaA_c.1380C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1389C>T dnaA_c.1389C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 57 74 20789 27394 0.00273433752278614 0.00207159836008266 0.00354121907298974 0.997305956021552 0.996619038569187 0.997884022005718 0.435114503816793 0.34875618113451 0.524472635229159 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.01499753637903 0.70533526845528 1.45402831285929 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 25 51 13349 21262 0.00186929863915059 0.00121006548869323 0.00275822519578355 0.997607094261718 0.996854956319785 0.998217821389018 0.328947368421052 0.225429804627353 0.446256594826305 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.780773767294017 0.463325083650457 1.2843366431265 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-138G>A dnaA_c.-138G>A 2 upstream_gene_variant 4411395 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5043 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.1398C>T dnaA_c.1398C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-139C>T dnaA_c.-139C>T 2 upstream_gene_variant 4411394 1 3 0 3 0 7 20846 27461 0 0 0.00017694296670111 0.999745158002038 0.999474999027776 0.999897534357495 0 0 0.409616397225003 0 0 0.707598226178713 0 0 0.409616397225003 0 0 3.18818879865849 0.264059517086452 427.5 5574 False False 0 0 0.914121240039481 0 0 0.00017694296670111 0.999745158002038 0.999474999027776 0.999897534357495 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3894 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 4 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-13G>A dnaA_c.-13G>A 2 upstream_gene_variant 4411520 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-13G>C dnaA_c.-13G>C 2 upstream_gene_variant 4411520 1 0 0 0 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4964 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3982 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.1401C>G dnaA_c.1401C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-140C>T dnaA_c.-140C>T 2 upstream_gene_variant 4411393 NA 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4819 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3859 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.1413A>G dnaA_c.1413A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1416C>A dnaA_c.1416C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1419C>T dnaA_c.1419C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-141G>A dnaA_c.-141G>A 2 upstream_gene_variant 4411392 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 5022 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4034 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-141G>T dnaA_c.-141G>T 2 upstream_gene_variant 4411392 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5104 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4105 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.1428C>T dnaA_c.1428C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-142T>C dnaA_c.-142T>C 2 upstream_gene_variant 4411391 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-144_-134delGTTGCCGGTAG dnaA_c.-144_-134delGTTGCCGGTAG 2 upstream_gene_variant 4411388 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4992 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4007 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.1443G>A dnaA_c.1443G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1443G>C dnaA_c.1443G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1446C>G dnaA_c.1446C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-144G>A dnaA_c.-144G>A 2 upstream_gene_variant 4411389 1 7 2 5 3 5 20843 27463 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999817970001456 0.999575254267103 0.999940892797913 0.375 0.0852334141372535 0.755136783633448 0.285714285714285 0.0366925661760855 0.709579136262657 0.285714285714285 0.0366925661760855 0.709579136262657 0.527045051096291 0.0501854026685452 3.22000686308128 0.706258531068192 1235.5 5574 False False 0.790567576644437 0.122780413850952 4.06394022809159 9.59462700887503e-05 1.16197496419179e-05 0.000346547484278011 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 1 3 2 3 13372 21310 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999859240838924 0.999588697652472 0.999970971136275 0.4 0.0527449505263169 0.853367200365326 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.531209492471831 0.010122774738481 6.6168053402183 1 1005 4479 False False 0 0 0 0 0 0 0 1.06241898494366 0.0886985485353837 9.27715037564111 7.47775368279368e-05 1.89320152683959e-06 0.000416562561410248 0.999859240838924 0.999588697652472 0.999970971136275 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.1455C>A dnaA_c.1455C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-145C>T dnaA_c.-145C>T 2 upstream_gene_variant 4411388 1 3 0 3 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18880616510555 0.264079043314886 541.5 5574 False False 0.439194051331254 0.00837049629364692 5.4704842261679 0 0 0.000176951454458875 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48598624162872 0.526186417038858 925 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.1461C>T dnaA_c.1461C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.544526627735454 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1464T>G dnaA_c.1464T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1467G>A dnaA_c.1467G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.18865318395302 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.85651838973546 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1473T>C dnaA_c.1473T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-147G>A dnaA_c.-147G>A 2 upstream_gene_variant 4411386 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5044 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4049 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.1482C>A dnaA_c.1482C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-149G>A dnaA_c.-149G>A 2 upstream_gene_variant 4411384 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4985 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-149G>C dnaA_c.-149G>C 2 upstream_gene_variant 4411384 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4890 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-149G>T dnaA_c.-149G>T 2 upstream_gene_variant 4411384 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-14A>C dnaA_c.-14A>C 2 upstream_gene_variant 4411519 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.1509G>A dnaA_c.1509G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1512C>T dnaA_c.1512C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.247471899512553 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.1518G>A dnaA_c.1518G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-151G>A dnaA_c.-151G>A 2 upstream_gene_variant 4411382 1 2 0 2 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 7.01573328293188 0.509380354735251 864 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4017 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.1524G>A dnaA_c.1524G>A 2 stop_retained_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-152C>A dnaA_c.-152C>A 2 upstream_gene_variant 4411381 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4829 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3867 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.153C>G dnaA_c.153C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-153T>C dnaA_c.-153T>C 2 upstream_gene_variant 4411380 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4941 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3961 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-155G>A dnaA_c.-155G>A 2 upstream_gene_variant 4411378 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5059 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4064 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-155G>C dnaA_c.-155G>C 2 upstream_gene_variant 4411378 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4814 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3856 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-156G>C dnaA_c.-156G>C 2 upstream_gene_variant 4411377 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-158G>A dnaA_c.-158G>A 2 upstream_gene_variant 4411375 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-159C>T dnaA_c.-159C>T 2 upstream_gene_variant 4411374 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.15C>T dnaA_c.15C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-15C>T dnaA_c.-15C>T 2 upstream_gene_variant 4411518 0 0 0 0 6 4 20840 27464 0.000287825002398541 0.000105633792978048 0.000626367784710498 0.999854376001165 0.999627187086024 0.999960320981843 0.6 0.262378076606945 0.878447741880172 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4993 5574 False False 1.9767754318618 0.468694569336888 9.5254553139328 0 0 0.000176993905465082 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 3 13370 21310 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 0.999859240838924 0.999588697652472 0.999970971136275 0.571428571428571 0.184051567640083 0.901011721557492 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4008 4479 False False 0 0 0 0 0 0 0 2.1251558214909 0.359459073814522 14.5112646280518 0 0 0.000275869155324334 0.999859240838924 0.999588697652472 0.999970971136275 2 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-160A>G dnaA_c.-160A>G 2 upstream_gene_variant 4411373 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4868 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3904 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-161C>T dnaA_c.-161C>T 2 upstream_gene_variant 4411372 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5080 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4085 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-162A>C dnaA_c.-162A>C 2 upstream_gene_variant 4411371 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5031 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4041 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.162G>A dnaA_c.162G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-163A>G dnaA_c.-163A>G 2 upstream_gene_variant 4411370 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5081 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4086 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.165C>T dnaA_c.165C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.544526627735454 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-167T>C dnaA_c.-167T>C 2 upstream_gene_variant 4411366 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-169G>T dnaA_c.-169G>T 2 upstream_gene_variant 4411364 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-16C>T dnaA_c.-16C>T 2 upstream_gene_variant 4411517 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.171C>T dnaA_c.171C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-171G>C dnaA_c.-171G>C 2 upstream_gene_variant 4411362 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-171G>T dnaA_c.-171G>T 2 upstream_gene_variant 4411362 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-172G>A dnaA_c.-172G>A 2 upstream_gene_variant 4411361 NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5045 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4050 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-173G>A dnaA_c.-173G>A 2 upstream_gene_variant 4411360 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5032 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4042 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-17A>G dnaA_c.-17A>G 2 upstream_gene_variant 4411516 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5012 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4023 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.180T>C dnaA_c.180T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 17 20843 27451 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999381098004951 0.999009262277189 0.999639426758727 0.15 0.0320709371854637 0.378926826545313 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.232418275567195 0.0436362565216145 0.803729427737468 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 10 13371 21303 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999530802796415 0.99913729947772 0.999774979505452 0.23076923076923 0.0503810734911515 0.53813153923404 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.477967242539825 0.0845118861353376 1.85677244072755 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-181C>G dnaA_c.-181C>G 2 upstream_gene_variant 4411352 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5023 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.183T>C dnaA_c.183T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-184_-183insA dnaA_c.-184_-183insA 2 upstream_gene_variant 4411349 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5046 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4051 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-184C>G dnaA_c.-184C>G 2 upstream_gene_variant 4411349 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.186G>A dnaA_c.186G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-186G>A dnaA_c.-186G>A 2 upstream_gene_variant 4411347 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4965 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.186G>C dnaA_c.186G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-186G>C dnaA_c.-186G>C 2 upstream_gene_variant 4411347 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 5047 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.186G>T dnaA_c.186G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-187G>A dnaA_c.-187G>A 2 upstream_gene_variant 4411346 1 5 0 5 0 6 20846 27462 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 1.43779998918648 0.0743349556518805 235.5 5574 False False 0 0 1.11900921779861 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 6 13374 21307 0 0 0.000275786657608973 0.999718481677849 0.999387354605726 0.999896680954833 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 1.73886488920615 0.163959928472831 238.5 4479 False False 0 0 0 0 0 0 0 0 0 1.35335561005417 0 0 0.000275786657608973 0.999718481677849 0.999387354605726 0.999896680954833 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.187T>C dnaA_c.187T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.63548263289195 0.137183409715989 155.34952410964 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-191G>A dnaA_c.-191G>A 2 upstream_gene_variant 4411342 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4942 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3962 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-191G>T dnaA_c.-191G>T 2 upstream_gene_variant 4411342 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-192G>A dnaA_c.-192G>A 2 upstream_gene_variant 4411341 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4830 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3868 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-192G>C dnaA_c.-192G>C 2 upstream_gene_variant 4411341 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-194G>A dnaA_c.-194G>A 2 upstream_gene_variant 4411339 1 1 0 1 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 0 0 0.975 0 0 0.521823750104981 0 0 51.3409520749508 1 2027.5 5574 False False 0 0 1.43785249906968 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 62.0829055149378 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-194G>T dnaA_c.-194G>T 2 upstream_gene_variant 4411339 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.195G>C dnaA_c.195G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.43785249906968 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 5 13374 21308 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.73894646374006 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.195G>T dnaA_c.195G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-197C>A dnaA_c.-197C>A 2 upstream_gene_variant 4411336 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4930 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-199G>A dnaA_c.-199G>A 2 upstream_gene_variant 4411334 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4869 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3905 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-19G>C dnaA_c.-19G>C 2 upstream_gene_variant 4411514 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.201C>T dnaA_c.201C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-201T>C dnaA_c.-201T>C 2 upstream_gene_variant 4411332 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-201T>G dnaA_c.-201T>G 2 upstream_gene_variant 4411332 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4953 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.204C>T dnaA_c.204C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.869878292971449 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 4 0 13370 21313 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 1 0.999826933785262 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.05210128917758 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-204G>A dnaA_c.-204G>A 2 upstream_gene_variant 4411329 1 16 0 16 1 20 20845 27448 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999271880005825 0.998875700613314 0.999555190458412 0.0476190476190476 0.00120488344836351 0.238159909936821 0 0 0.205907214207822 0 0 0.168433470983085 0 0 0.341491898987486 0.000150640318789567 63 5574 True False 0.0658383305349004 0.00159270996657629 0.411717550396138 0 0 0.000176951454458875 0.999271880005825 0.998875700613314 0.999555190458412 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 14 0 14 1 17 13373 21296 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999202364753906 0.998723214865585 0.999535281595187 0.0555555555555555 0.00140555616736942 0.272943599673368 0 0 0.231635761650116 0 0 0.195064322969093 0 0 0.48018257514251 0.00149836619155304 58 4479 False False 0 0 0 0 0 0 0 0.0936742602522202 0.00224547098341481 0.5980024962562 0 0 0.000275807277411719 0.999202364753906 0.998723214865585 0.999535281595187 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-205C>T dnaA_c.-205C>T 2 upstream_gene_variant 4411328 1 4 1 3 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.439194051331254 0.00837049629364692 5.4704842261679 0.638942720978879 1228.5 5574 False False 0.439194051331254 0.00837049629364692 5.4704842261679 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 1 3 1 3 13373 21310 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999859240838924 0.999588697652472 0.999970971136275 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.531169769934445 0.010122018243966 6.61631049307563 1 1642.5 4479 False False 0 0 0 0 0 0 0 0.531169769934445 0.010122018243966 6.61631049307563 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-206G>A dnaA_c.-206G>A 2 upstream_gene_variant 4411327 1 6 0 6 1 6 20845 27462 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999781564001747 0.999524617886493 0.999919833755107 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.11906289991934 0.040214073694581 205 5574 False False 0.219573039098105 0.00477770915407814 1.81014820057657 0 0 0.000176951454458875 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 1 6 13373 21307 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999718481677849 0.999387354605726 0.999896680954833 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.35345678111722 0.0884835334370246 175 4479 False False 0 0 0 0 0 0 0 0.265547496198808 0.00577686092206708 2.18912593855065 0 0 0.000275807277411719 0.999718481677849 0.999387354605726 0.999896680954833 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-206G>C dnaA_c.-206G>C 2 upstream_gene_variant 4411327 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-207G>A dnaA_c.-207G>A 2 upstream_gene_variant 4411326 1 0 0 0 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 4891 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 3922 4479 False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 0 0 0.000275827900298067 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-207G>C dnaA_c.-207G>C 2 upstream_gene_variant 4411326 1 2 1 1 2 2 20844 27466 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999927188000582 0.999737003036386 0.999991182007438 0.5 0.067585986488543 0.932414013511457 0.5 0.012579117093425 0.987420882906574 0.333333333333333 0.00840375865961264 0.905700675949754 1.3176933410094 0.0167929463371296 103.358311851004 1 2027.5 5574 False False 1.3176933410094 0.0955278435529395 18.1762534351792 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 2 2 13372 21311 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999906160559283 0.999661061221376 0.999988635406343 0.5 0.067585986488543 0.932414013511457 0.5 0.012579117093425 0.987420882906574 0.333333333333333 0.00840375865961264 0.905700675949754 1.59370326054442 0.0203011231771187 124.987291663967 1 1005 4479 False False 0 0 0 0 0 0 0 1.59370326054442 0.115491055908661 21.9865025501046 7.47775368279368e-05 1.89320152683959e-06 0.000416562561410248 0.999906160559283 0.999661061221376 0.999988635406343 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-209A>G dnaA_c.-209A>G 2 upstream_gene_variant 4411324 NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4815 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-20A>C dnaA_c.-20A>C 2 upstream_gene_variant 4411513 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4914 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-210G>A dnaA_c.-210G>A 2 upstream_gene_variant 4411323 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-211G>A dnaA_c.-211G>A 2 upstream_gene_variant 4411322 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-211G>C dnaA_c.-211G>C 2 upstream_gene_variant 4411322 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-212A>C dnaA_c.-212A>C 2 upstream_gene_variant 4411321 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4976 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-213G>C dnaA_c.-213G>C 2 upstream_gene_variant 4411320 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5089 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4094 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-214C>T dnaA_c.-214C>T 2 upstream_gene_variant 4411319 1 3 0 3 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.18853708762714 0.264070532102877 442 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.85633740727807 0.289259828934126 294 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-215G>C dnaA_c.-215G>C 2 upstream_gene_variant 4411318 1 2 0 2 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01632529799099 0.509386028876591 1135.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48598624162872 0.526186417038858 925 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-216A>C dnaA_c.-216A>C 2 upstream_gene_variant 4411317 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5060 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-219T>G dnaA_c.-219T>G 2 upstream_gene_variant 4411314 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-221A>C dnaA_c.-221A>C 2 upstream_gene_variant 4411312 NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4902 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3930 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-221A>G dnaA_c.-221A>G 2 upstream_gene_variant 4411312 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-223A>G dnaA_c.-223A>G 2 upstream_gene_variant 4411310 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4820 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3860 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-224G>A dnaA_c.-224G>A 2 upstream_gene_variant 4411309 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5048 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4052 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-224G>C dnaA_c.-224G>C 2 upstream_gene_variant 4411309 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.225G>A dnaA_c.225G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 5 20843 27463 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999817970001456 0.999575254267103 0.999940892797913 0.375 0.0852334141372535 0.755136783633448 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.790567576644437 0.122780413850952 4.06394022809159 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.41420404242617 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-226T>C dnaA_c.-226T>C 2 upstream_gene_variant 4411307 1 2 0 2 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 7.01573328293188 0.509380354735251 864 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.48495357236853 0.526173219289417 690 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-226T>G dnaA_c.-226T>G 2 upstream_gene_variant 4411307 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-22C>A dnaA_c.-22C>A 2 upstream_gene_variant 4411511 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-230G>A dnaA_c.-230G>A 2 upstream_gene_variant 4411303 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-231G>T dnaA_c.-231G>T 2 upstream_gene_variant 4411302 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4892 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-232C>A dnaA_c.-232C>A 2 upstream_gene_variant 4411301 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4821 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3861 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.232C>T dnaA_c.232C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 13 20846 27455 0 0 0.00017694296670111 0.999526722003786 0.99919081619501 0.999747976101462 0 0 0.24705263800047 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.432228279580125 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 13 13374 21300 0 0 0.000275786657608973 0.99939004363534 0.998957181904114 0.999675185224884 0 0 0.24705263800047 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.522684266329562 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.234G>C dnaA_c.234G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-236G>A dnaA_c.-236G>A 2 upstream_gene_variant 4411297 NA 0 0 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 4986 5574 False False Inf 0.869878292971449 Inf 0 0 0.000176976922618654 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 13370 21313 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 1 0.999826933785262 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3999 4479 False False 0 0 0 0 0 0 0 Inf 1.05210128917758 Inf 0 0 0.000275869155324334 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.237G>A dnaA_c.237G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 21 64 20825 27404 0.00100738750839489 0.000623693493785757 0.00153948878572471 0.99767001601864 0.997025622876796 0.998205180195353 0.247058823529411 0.159898095860745 0.352529015062074 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.431785714285714 0.250376471679862 0.716746633835751 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 13 52 13361 21261 0.000972035292358307 0.000517666151348512 0.00166163634851859 0.997560174541359 0.99680170921955 0.998177301237617 0.2 0.111015834886745 0.31768797188169 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.397818277075069 0.198642341222832 0.741278339471769 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-237G>A dnaA_c.-237G>A 2 upstream_gene_variant 4411296 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-238T>C dnaA_c.-238T>C 2 upstream_gene_variant 4411295 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5082 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4087 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-239G>A dnaA_c.-239G>A 2 upstream_gene_variant 4411294 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-241_-240insCGTGGAAACGGCACTCGA dnaA_c.-241_-240insCGTGGAAACGGCACTCGA 2 upstream_gene_variant 4411292 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4915 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3941 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-241G>A dnaA_c.-241G>A 2 upstream_gene_variant 4411292 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-242A>C dnaA_c.-242A>C 2 upstream_gene_variant 4411291 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5061 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4065 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-242A>G dnaA_c.-242A>G 2 upstream_gene_variant 4411291 NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4943 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3963 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-243C>T dnaA_c.-243C>T 2 upstream_gene_variant 4411290 1 1 0 1 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 51.349017027227 1 2027.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 62.0933648450895 1 1642.5 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-245T>G dnaA_c.-245T>G 2 upstream_gene_variant 4411288 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5049 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4053 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-247G>T dnaA_c.-247G>T 2 upstream_gene_variant 4411286 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4831 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3869 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-248C>A dnaA_c.-248C>A 2 upstream_gene_variant 4411285 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5062 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.249C>T dnaA_c.249C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-249C>T dnaA_c.-249C>T 2 upstream_gene_variant 4411284 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-249delC dnaA_c.-249delC 2 upstream_gene_variant 4411283 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4822 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3862 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-250G>A dnaA_c.-250G>A 2 upstream_gene_variant 4411283 1 1 0 1 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 51.3446878573018 1 2027.5 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-251C>T dnaA_c.-251C>T 2 upstream_gene_variant 4411282 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5033 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4043 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-254T>C dnaA_c.-254T>C 2 upstream_gene_variant 4411279 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-257T>C dnaA_c.-257T>C 2 upstream_gene_variant 4411276 NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4903 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3931 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.258C>G dnaA_c.258C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-259A>C dnaA_c.-259A>C 2 upstream_gene_variant 4411274 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-260T>C dnaA_c.-260T>C 2 upstream_gene_variant 4411273 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-261G>A dnaA_c.-261G>A 2 upstream_gene_variant 4411272 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 5083 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4088 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 2 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-261G>C dnaA_c.-261G>C 2 upstream_gene_variant 4411272 1 0 0 0 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4893 5574 False False 0.439194051331254 0.00837049629364692 5.4704842261679 0 0 0.000176951454458875 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3923 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-263G>A dnaA_c.-263G>A 2 upstream_gene_variant 4411270 1 2 1 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.31774131644597 0.016793557463775 103.362071688999 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4112 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-263G>C dnaA_c.-263G>C 2 upstream_gene_variant 4411270 1 1 0 1 5 1 20841 27467 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.999963594000291 0.999797175631493 0.999999078280314 0.833333333333333 0.358765421002325 0.99578925548551 0 0 0.975 0 0 0.975 0 0 51.360732841256 1 2027.5 5574 False False 6.58965500695744 0.737267067818355 311.215258952954 0 0 0.000176985413634466 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 2 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-264G>C dnaA_c.-264G>C 2 upstream_gene_variant 4411269 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4954 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3974 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-266G>A dnaA_c.-266G>A 2 upstream_gene_variant 4411267 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5113 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-266G>C dnaA_c.-266G>C 2 upstream_gene_variant 4411267 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.267A>C dnaA_c.267A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.18865318395302 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-267G>C dnaA_c.-267G>C 2 upstream_gene_variant 4411266 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5034 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4044 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-268G>A dnaA_c.-268G>A 2 upstream_gene_variant 4411265 1 1 0 1 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 51.3446878573018 1 2027.5 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 62.0858160113928 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-268G>C dnaA_c.-268G>C 2 upstream_gene_variant 4411265 NA 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 5084 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4089 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.270C>T dnaA_c.270C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-272C>G dnaA_c.-272C>G 2 upstream_gene_variant 4411261 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-273G>A dnaA_c.-273G>A 2 upstream_gene_variant 4411260 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4944 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3964 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.279G>A dnaA_c.279G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.18865318395302 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.85651838973546 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-280A>G dnaA_c.-280A>G 2 upstream_gene_variant 4411253 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-281A>C dnaA_c.-281A>C 2 upstream_gene_variant 4411252 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4883 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3916 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-285G>C dnaA_c.-285G>C 2 upstream_gene_variant 4411248 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4987 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-286C>G dnaA_c.-286C>G 2 upstream_gene_variant 4411247 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4931 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3954 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-289G>A dnaA_c.-289G>A 2 upstream_gene_variant 4411244 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4977 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3991 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-289G>T dnaA_c.-289G>T 2 upstream_gene_variant 4411244 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-291C>T dnaA_c.-291C>T 2 upstream_gene_variant 4411242 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.291G>A dnaA_c.291G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-293A>G dnaA_c.-293A>G 2 upstream_gene_variant 4411240 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4858 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3895 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-299G>A dnaA_c.-299G>A 2 upstream_gene_variant 4411234 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-29G>A dnaA_c.-29G>A 2 upstream_gene_variant 4411504 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.300C>T dnaA_c.300C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-300G>C dnaA_c.-300G>C 2 upstream_gene_variant 4411233 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-302A>G dnaA_c.-302A>G 2 upstream_gene_variant 4411231 NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5072 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4074 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-307A>C dnaA_c.-307A>C 2 upstream_gene_variant 4411226 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 5024 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4035 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.309G>C dnaA_c.309G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 10 20843 27458 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999635940002912 0.999330582956894 0.999825405716755 0.23076923076923 0.0503810734911515 0.53813153923404 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.395211821714724 0.0698820144739222 1.53517921560294 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 5 13374 21308 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.73894646374006 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-30G>T dnaA_c.-30G>T 2 upstream_gene_variant 4411503 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-311C>G dnaA_c.-311C>G 2 upstream_gene_variant 4411222 1 0 0 0 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 5105 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 4106 4479 False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 0 0 0.000275827900298067 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-311C>T dnaA_c.-311C>T 2 upstream_gene_variant 4411222 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-312A>G dnaA_c.-312A>G 2 upstream_gene_variant 4411221 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4978 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3992 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.312G>A dnaA_c.312G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.315C>G dnaA_c.315C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.315C>T dnaA_c.315C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-31C>G dnaA_c.-31C>G 2 upstream_gene_variant 4411502 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4945 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3965 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.324C>G dnaA_c.324C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 14 20842 27454 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999490316004077 0.999144984581285 0.999721323894632 0.222222222222222 0.0640920477176664 0.47637276573648 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.376355436138566 0.0901746298465822 1.19862055087743 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 4 13 13370 21300 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 0.99939004363534 0.998957181904114 0.999675185224884 0.235294117647058 0.0681077404373566 0.49899327320458 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.490190437834416 0.116409027471203 1.58722335447133 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-32C>T dnaA_c.-32C>T 2 upstream_gene_variant 4411501 NA 0 0 0 126 661 20720 26807 0.00604432505036937 0.00503750876025936 0.00719238853811199 0.975935634192515 0.974053979090631 0.977715666397899 0.160101651842439 0.135158544574968 0.187621135445227 NA NA NA 0 0 0.00556521211549389 NA NA NA NA 5106 5574 False True 0.246619577217156 0.202024769881365 0.299083163019883 0 0 0.000178018875448122 0.975935634192515 0.974053979090631 0.977715666397899 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 100 479 13274 20834 0.00747719455660236 0.00608776467976969 0.00908690953839941 0.977525453948294 0.975445711609946 0.979473493547921 0.172711571675302 0.142793357628284 0.206013151881407 NA NA NA 0 0 0.00767163137912907 NA NA NA NA 4107 4479 False True 0 1 1 0 0 0 0 0.327668982923907 0.26119820088988 0.407747209847564 0 0 0.000277864014385219 0.977525453948294 0.975445711609946 0.979473493547921 10 5) Not assoc w R New NotAwR yes 5 +Isoniazid dnaA c.333T>A dnaA_c.333T>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.33A>G dnaA_c.33A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-33C>A dnaA_c.-33C>A 2 upstream_gene_variant 4411500 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4904 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3932 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-33C>T dnaA_c.-33C>T 2 upstream_gene_variant 4411500 NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5090 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-33delC dnaA_c.-33delC 2 upstream_gene_variant 4411499 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.342G>A dnaA_c.342G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 19 2 20827 27466 0.000911445840928715 0.000548836318218138 0.00142297127227785 0.999927188000582 0.999737003036386 0.999991182007438 0.904761904761904 0.696225593086075 0.988250682115554 NA NA NA NA NA NA NA NA NA NA NA NA False False 12.5283046045997 3.02173590603041 111.007605235237 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 18 2 13356 21311 0.00134589502018842 0.000797851614369596 0.00212626349435784 0.999906160559283 0.999661061221376 0.999988635406343 0.9 0.683017285980917 0.987651472829705 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 14.36051212938 3.43704101911601 127.828979525438 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.348C>G dnaA_c.348C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 1 20842 27467 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999963594000291 0.999797175631493 0.999999078280314 0.8 0.28358206388191 0.994949236620532 NA NA NA NA NA NA NA NA NA NA NA NA False False 5.27147106803569 0.521589398427432 259.279173455301 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-34A>G dnaA_c.-34A>G 2 upstream_gene_variant 4411499 1 2 0 2 1 4 20845 27464 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999854376001165 0.999627187086024 0.999960320981843 0.2 0.00505076337946806 0.716417936118089 0 0 0.841886116991581 0 0 0.602364635616474 0 0 7.01581441470222 0.509381131851925 880 5574 False False 0.329383545214679 0.00669260119676484 3.32889360843958 0 0 0.000176951454458875 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.354T>C dnaA_c.354T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.18865318395302 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.85651838973546 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.357T>C dnaA_c.357T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.363C>T dnaA_c.363C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.372A>C dnaA_c.372A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.375C>T dnaA_c.375C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.378C>G dnaA_c.378C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.387C>T dnaA_c.387C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-38C>A dnaA_c.-38C>A 2 upstream_gene_variant 4411495 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-38C>G dnaA_c.-38C>G 2 upstream_gene_variant 4411495 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.390C>T dnaA_c.390C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 6 20845 27462 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999781564001747 0.999524617886493 0.999919833755107 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.219573039098105 0.00477770915407814 1.81014820057657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 4 13373 21309 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999812321118566 0.999519537882235 0.999948861529775 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.398358633066626 0.00809276091420046 4.02622197901862 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.393C>T dnaA_c.393C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.402T>C dnaA_c.402T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.247471899512553 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-40A>C dnaA_c.-40A>C 2 upstream_gene_variant 4411493 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.414G>A dnaA_c.414G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.414G>T dnaA_c.414G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.417A>G dnaA_c.417A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.418C>A dnaA_c.418C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 30 0 20816 27468 0.0014391250119927 0.000971175699964354 0.00205380828868033 1 0.999865711673152 1 1 0.884296691777972 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 10.0820642066904 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 30 0 13344 21313 0.0022431583669807 0.00151394553527843 0.00320071210053849 1 0.999826933785262 1 1 0.884296691777972 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 12.2010242542256 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.429C>T dnaA_c.429C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 7 20846 27461 0 0 0.00017694296670111 0.999745158002038 0.999474999027776 0.999897534357495 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.914121240039481 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 6 13374 21307 0 0 0.000275786657608973 0.999718481677849 0.999387354605726 0.999896680954833 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.35335561005417 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-42G>A dnaA_c.-42G>A 2 upstream_gene_variant 4411491 NA 0 0 0 6 0 20840 27468 0.000287825002398541 0.000105633792978048 0.000626367784710498 1 0.999865711673152 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 5073 5574 False False Inf 1.55167078958407 Inf 0 0 0.000176993905465082 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 5 0 13369 21313 0.000373859727830118 0.000121402023062639 0.000872246401868143 1 0.999826933785262 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 4075 4479 False False 0 0 0 0 0 0 0 Inf 1.46057233596553 Inf 0 0 0.000275889787465637 1 0.999826933785262 1 2 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-42G>C dnaA_c.-42G>C 2 upstream_gene_variant 4411491 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-43G>A dnaA_c.-43G>A 2 upstream_gene_variant 4411490 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.447T>C dnaA_c.447T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.465G>C dnaA_c.465G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-46C>A dnaA_c.-46C>A 2 upstream_gene_variant 4411487 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-46C>G dnaA_c.-46C>G 2 upstream_gene_variant 4411487 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-46delC dnaA_c.-46delC 2 upstream_gene_variant 4411486 1 0 0 0 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4823 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3863 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-47A>C dnaA_c.-47A>C 2 upstream_gene_variant 4411486 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-47A>G dnaA_c.-47A>G 2 upstream_gene_variant 4411486 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4009 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-48_-36delGACCCGGAACCAA dnaA_c.-48_-36delGACCCGGAACCAA 2 upstream_gene_variant 4411484 1 4 0 4 5 24 20841 27444 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.99912625600699 0.998700215334872 0.99944009803271 0.172413793103448 0.0584560829726344 0.357747554414644 0 0 0.602364635616474 0 0 0.142473597722525 0 0 1.99507448009559 0.139068484994901 295 5574 False False 0.27433904323209 0.0817735889750175 0.733682274130147 0 0 0.000176985413634466 0.99912625600699 0.998700215334872 0.99944009803271 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 2 22 13372 21291 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.998967766152113 0.998437600176231 0.999352995040555 0.0833333333333333 0.0102563412812501 0.269972801557603 0 0 0.707598226178713 0 0 0.154372512815574 0 0 3.85365612387339 0.2891467797674 277 4479 False False 0 0 0 0 0 0 0 0.144746145269627 0.0164882441863655 0.588995830637876 0 0 0.000275827900298067 0.998967766152113 0.998437600176231 0.999352995040555 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.486C>T dnaA_c.486C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.489T>A dnaA_c.489T>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.48C>T dnaA_c.48C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-48G>A dnaA_c.-48G>A 2 upstream_gene_variant 4411485 NA 0 0 0 0 53 20846 27415 0 0 0.00017694296670111 0.998070482015436 0.99747689318098 0.998554334822754 0 0 0.0672345463063011 NA NA NA 0 0 0.0672345463063011 NA NA NA NA 4870 5574 False True 0 0 0.0948068991599693 0 0 0.00017694296670111 0.998070482015436 0.99747689318098 0.998554334822754 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 53 13374 21260 0 0 0.000275786657608973 0.997513254821001 0.996748522263028 0.998136719289214 0 0 0.0672345463063011 NA NA NA 0 0 0.0672345463063011 NA NA NA NA 3906 4479 False True 1 1 1 0 0 0 0 0 0 0.114610079571832 0 0 0.000275786657608973 0.997513254821001 0.996748522263028 0.998136719289214 NA 5) Not assoc w R New NotAwR yes 5 +Isoniazid dnaA c.-48G>C dnaA_c.-48G>C 2 upstream_gene_variant 4411485 NA 0 0 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 4894 5574 False False Inf 0.869878292971449 Inf 0 0 0.000176976922618654 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.495A>G dnaA_c.495A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.501C>T dnaA_c.501C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.519C>G dnaA_c.519C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 66 20846 27402 0 0 0.00017694296670111 0.997597204019222 0.996944054585192 0.998141205312715 0 0 0.0543588471701219 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 0 0.075588863906732 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 0 66 13374 21247 0 0 0.000275786657608973 0.996903298456341 0.996061897866114 0.997604226340642 0 0 0.0543588471701219 NA NA NA NA NA NA NA NA NA NA NA NA False True 1 1 1 0 0 0 0 0 0 0.0913442900140524 NA NA NA NA NA NA NA 5) Not assoc w R Now listed Silent mutation no 0 +Isoniazid dnaA c.519C>T dnaA_c.519C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 1 20842 27467 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999963594000291 0.999797175631493 0.999999078280314 0.8 0.28358206388191 0.994949236620532 NA NA NA NA NA NA NA NA NA NA NA NA False False 5.27147106803569 0.521589398427432 259.279173455301 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-51C>G dnaA_c.-51C>G 2 upstream_gene_variant 4411482 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.522T>C dnaA_c.522T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-52G>A dnaA_c.-52G>A 2 upstream_gene_variant 4411481 1 6 0 6 0 6 20846 27462 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.11900921779861 0.0402109359097128 194.5 5574 False False 0 0 1.11900921779861 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 13374 21307 0 0 0.000275786657608973 0.999718481677849 0.999387354605726 0.999896680954833 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.35335561005417 0.0884814409570568 164 4479 False False 0 0 0 0 0 0 0 0 0 1.35335561005417 0 0 0.000275786657608973 0.999718481677849 0.999387354605726 0.999896680954833 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-52G>C dnaA_c.-52G>C 2 upstream_gene_variant 4411481 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.531C>T dnaA_c.531C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 4 20844 27464 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999854376001165 0.999627187086024 0.999960320981843 0.333333333333333 0.0432718682927417 0.777221904496487 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.658798695068125 0.0595601499680727 4.59736120623929 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 4 13373 21309 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999812321118566 0.999519537882235 0.999948861529775 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.398358633066626 0.00809276091420046 4.02622197901862 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.534T>C dnaA_c.534T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.537C>A dnaA_c.537C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.540C>T dnaA_c.540C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.543C>A dnaA_c.543C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-54T>C dnaA_c.-54T>C 2 upstream_gene_variant 4411479 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.552G>A dnaA_c.552G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-55G>C dnaA_c.-55G>C 2 upstream_gene_variant 4411478 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4995 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.564C>A dnaA_c.564C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.576G>A dnaA_c.576G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 6 20845 27462 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999781564001747 0.999524617886493 0.999919833755107 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.219573039098105 0.00477770915407814 1.81014820057657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 6 13373 21307 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999718481677849 0.999387354605726 0.999896680954833 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.265547496198808 0.00577686092206708 2.18912593855065 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-57T>C dnaA_c.-57T>C 2 upstream_gene_variant 4411476 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4979 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3993 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.582A>C dnaA_c.582A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-58G>A dnaA_c.-58G>A 2 upstream_gene_variant 4411475 NA 0 0 0 70 253 20776 27215 0.00335795836131631 0.00261860038191089 0.00424070087457446 0.990789282073685 0.989587896342083 0.991885053238866 0.216718266253869 0.173018047668555 0.265698705906087 NA NA NA 0 0 0.0144747697069241 NA NA NA NA 4895 5574 False True 0.362429817926126 0.273882500894457 0.474309791749514 0 0 0.000177539082801605 0.990789282073685 0.989587896342083 0.991885053238866 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 66 227 13308 21086 0.00493494840735756 0.00381868331061345 0.00627424362815551 0.989349223478628 0.98787882314278 0.990683752851239 0.225255972696245 0.178710062738766 0.277453067844832 NA NA NA 0 0 0.0161192421133921 NA NA NA NA 3924 4479 False True 0 1 1 0 0 0 0 0.460680138077324 0.344467114341568 0.609009623029134 0 0 0.000277154210719914 0.989349223478628 0.98787882314278 0.990683752851239 9 5) Not assoc w R New NotAwR yes 5 +Isoniazid dnaA c.594C>A dnaA_c.594C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.597C>G dnaA_c.597C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-59G>A dnaA_c.-59G>A 2 upstream_gene_variant 4411474 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.603C>T dnaA_c.603C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.606C>T dnaA_c.606C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.612G>A dnaA_c.612G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.18865318395302 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.85651838973546 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.624C>T dnaA_c.624C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.630C>T dnaA_c.630C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.636C>T dnaA_c.636C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.639C>A dnaA_c.639C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-63C>G dnaA_c.-63C>G 2 upstream_gene_variant 4411470 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-63C>T dnaA_c.-63C>T 2 upstream_gene_variant 4411470 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4846 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3882 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.645A>C dnaA_c.645A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 29 0 20817 27468 0.00139115417825961 0.000931869577538548 0.00199732323166199 1 0.999865711673152 1 1 0.880555130930497 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 9.724633441073 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 24 0 13350 21313 0.00179452669358456 0.00115011499978073 0.00266894436176925 1 0.999826933785262 1 1 0.857526402277474 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 9.60550580369955 Inf NA NA NA NA NA NA 23 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.645A>G dnaA_c.645A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.649C>T dnaA_c.649C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 12 20846 27456 0 0 0.00017694296670111 0.999563128003495 0.99923699702714 0.999774242139628 0 0 0.264648469397051 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.474072891853425 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 10 13374 21303 0 0 0.000275786657608973 0.999530802796415 0.99913729947772 0.999774979505452 0 0 0.30849710781876 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.710765762832934 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.654A>C dnaA_c.654A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.657C>T dnaA_c.657C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.660G>A dnaA_c.660G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.660G>C dnaA_c.660G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.663A>G dnaA_c.663A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.666C>A dnaA_c.666C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.666C>T dnaA_c.666C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-66C>T dnaA_c.-66C>T 2 upstream_gene_variant 4411467 1 4 1 3 5 4 20841 27464 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.999854376001165 0.999627187086024 0.999960320981843 0.555555555555555 0.212008506778868 0.863004337734833 0.25 0.00630946320970987 0.805879550316756 0.2 0.00505076337946806 0.716417936118089 0.439262351454664 0.00837179706363874 5.4713337775783 0.638958114107018 1232 5574 False False 1.64723381795499 0.354499279020611 8.30243796120459 4.79800403032338e-05 1.21474870966795e-06 0.000267298357449221 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 4 2 13370 21311 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 0.999906160559283 0.999661061221376 0.999988635406343 0.666666666666666 0.222778095503512 0.956728131707258 0 0 0.975 0 0 0.841886116991581 0 0 62.107284016625 1 1642.5 4479 False False 0 0 0 0 0 0 0 3.18788332086761 0.456775580099959 35.246992707007 0 0 0.000275869155324334 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.672T>C dnaA_c.672T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.18865318395302 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.85651838973546 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.675C>G dnaA_c.675C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.675C>T dnaA_c.675C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.678A>G dnaA_c.678A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.658815063564403 0.011171855707321 12.6567401482543 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.684G>A dnaA_c.684G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.63548263289195 0.137183409715989 155.34952410964 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-68C>G dnaA_c.-68C>G 2 upstream_gene_variant 4411465 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4896 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3925 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-68C>T dnaA_c.-68C>T 2 upstream_gene_variant 4411465 1 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4871 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3907 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.693A>G dnaA_c.693A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 5 0 20841 27468 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 1 0.999865711673152 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.20760984683633 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 4 0 13370 21313 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 1 0.999826933785262 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.05210128917758 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.699G>A dnaA_c.699G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.699G>C dnaA_c.699G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.869878292971449 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 4 0 13370 21313 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 1 0.999826933785262 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.05210128917758 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-69C>G dnaA_c.-69C>G 2 upstream_gene_variant 4411464 1 0 0 0 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4847 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3883 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.69C>T dnaA_c.69C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.439194051331254 0.00837049629364692 5.4704842261679 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-69C>T dnaA_c.-69C>T 2 upstream_gene_variant 4411464 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5013 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4024 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.702C>A dnaA_c.702C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-70C>G dnaA_c.-70C>G 2 upstream_gene_variant 4411463 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4946 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3966 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.711C>T dnaA_c.711C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.714C>G dnaA_c.714C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-71G>A dnaA_c.-71G>A 2 upstream_gene_variant 4411462 1 2 0 2 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01632529799099 0.509386028876591 1135.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.729C>G dnaA_c.729C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.729C>T dnaA_c.729C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-73_-70delCTGCinsG dnaA_c.-73_-70delCTGCinsG 2 upstream_gene_variant 4411460 1 6 0 6 0 6 20846 27462 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.11900921779861 0.0402109359097128 194.5 5574 False False 0 0 1.11900921779861 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-73C>A dnaA_c.-73C>A 2 upstream_gene_variant 4411460 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.741T>C dnaA_c.741T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-74C>G dnaA_c.-74C>G 2 upstream_gene_variant 4411459 0 0 0 0 2 8 20844 27460 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.99970875200233 0.999426206431739 0.999874251669172 0.2 0.0252107263268333 0.556095462307641 NA NA NA 0 0 0.369416647552819 NA NA NA NA 4848 5574 False False 0.329351372097486 0.0340635477373695 1.6506834450398 0 0 0.000176959943030976 0.99970875200233 0.999426206431739 0.999874251669172 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 5 13373 21308 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999765401398207 0.999452610763328 0.999923822225278 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA 0 0 0.521823750104981 NA NA NA NA 3884 4479 False False 0 0 0 0 0 0 0 0.318671950945935 0.00674139558547252 2.84834809554519 0 0 0.000275807277411719 0.999765401398207 0.999452610763328 0.999923822225278 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-74C>T dnaA_c.-74C>T 2 upstream_gene_variant 4411459 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.750C>T dnaA_c.750C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 1 20843 27467 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999963594000291 0.999797175631493 0.999999078280314 0.75 0.194120449683243 0.99369053679029 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.95341361608213 0.31739219148065 207.323829234655 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.762C>A dnaA_c.762C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.18865318395302 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.762C>G dnaA_c.762C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-76C>G dnaA_c.-76C>G 2 upstream_gene_variant 4411457 1 2 0 2 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 7.01573328293188 0.509380354735251 864 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.48495357236853 0.526173219289417 690 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-76C>T dnaA_c.-76C>T 2 upstream_gene_variant 4411457 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.774C>T dnaA_c.774C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-77T>A dnaA_c.-77T>A 2 upstream_gene_variant 4411456 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4824 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.780C>T dnaA_c.780C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.99604811372315 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.85651838973546 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.783C>T dnaA_c.783C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-78T>C dnaA_c.-78T>C 2 upstream_gene_variant 4411455 1 2 0 2 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 7.01547785354097 0.509377906736075 843 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.78T>G dnaA_c.78T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.18865318395302 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.795A>C dnaA_c.795A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.247471899512553 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.798C>T dnaA_c.798C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-81C>A dnaA_c.-81C>A 2 upstream_gene_variant 4411452 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4966 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3983 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.81C>T dnaA_c.81C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 23 20846 27445 0 0 0.00017694296670111 0.999162662006698 0.998743845166008 0.999469127824854 0 0 0.148185128915224 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.229082018740918 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 23 13374 21290 0 0 0.000275786657608973 0.998920846431755 0.998381177107211 0.999315790080537 0 0 0.148185128915224 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.277001094079837 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-81C>T dnaA_c.-81C>T 2 upstream_gene_variant 4411452 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5085 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4090 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.828T>C dnaA_c.828T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-82A>G dnaA_c.-82A>G 2 upstream_gene_variant 4411451 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.834C>G dnaA_c.834C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-83G>C dnaA_c.-83G>C 2 upstream_gene_variant 4411450 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.843T>C dnaA_c.843T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.84C>T dnaA_c.84C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-84G>C dnaA_c.-84G>C 2 upstream_gene_variant 4411449 1 2 0 2 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 7.01573328293188 0.509380354735251 864 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.48495357236853 0.526173219289417 690 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-84G>T dnaA_c.-84G>T 2 upstream_gene_variant 4411449 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5025 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4036 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.852G>A dnaA_c.852G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.855G>A dnaA_c.855G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.867C>G dnaA_c.867C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.867C>T dnaA_c.867C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.870C>T dnaA_c.870C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.873C>T dnaA_c.873C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.879G>A dnaA_c.879G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.891C>T dnaA_c.891C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-89C>T dnaA_c.-89C>T 2 upstream_gene_variant 4411444 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4859 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3896 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.903C>G dnaA_c.903C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.909A>C dnaA_c.909A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.909A>T dnaA_c.909A>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.90C>T dnaA_c.90C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-91_-90insC dnaA_c.-91_-90insC 2 upstream_gene_variant 4411442 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4980 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3994 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-91G>A dnaA_c.-91G>A 2 upstream_gene_variant 4411442 1 0 0 0 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 4947 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3967 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-91G>C dnaA_c.-91G>C 2 upstream_gene_variant 4411442 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4872 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3908 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.-91G>T dnaA_c.-91G>T 2 upstream_gene_variant 4411442 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.921A>C dnaA_c.921A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.921A>G dnaA_c.921A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.936C>A dnaA_c.936C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.939C>A dnaA_c.939C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 10 38 20836 27430 0.000479708337330902 0.000230061997553563 0.000882023176671562 0.998616572011067 0.998101626446224 0.999020823782757 0.208333333333333 0.104690683032906 0.349910240257326 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.346439866223439 0.153912834143801 0.708810857533976 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 10 37 13364 21276 0.000747719455660236 0.000358616922835118 0.00137465137870696 0.998263970346736 0.997607897850502 0.99877738945907 0.212765957446808 0.107032477154785 0.356636987762992 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.430280624833154 0.190759262466523 0.882922972375265 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-93T>C dnaA_c.-93T>C 2 upstream_gene_variant 4411440 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5035 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.949C>A dnaA_c.949C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-95G>A dnaA_c.-95G>A 2 upstream_gene_variant 4411438 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4860 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3897 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.960C>T dnaA_c.960C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.658815063564403 0.011171855707321 12.6567401482543 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.975G>A dnaA_c.975G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.976C>T dnaA_c.976C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 7 20846 27461 0 0 0.00017694296670111 0.999745158002038 0.999474999027776 0.999897534357495 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.914121240039481 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 6 13374 21307 0 0 0.000275786657608973 0.999718481677849 0.999387354605726 0.999896680954833 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.35335561005417 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.981C>A dnaA_c.981C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.984T>C dnaA_c.984T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.-98G>T dnaA_c.-98G>T 2 upstream_gene_variant 4411435 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4838 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3875 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA c.990A>G dnaA_c.990A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA c.996A>C dnaA_c.996A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.658815063564403 0.011171855707321 12.6567401482543 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid dnaA LoF dnaA_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala101Asp dnaA_p.Ala101Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 5091 5574 False False Inf 0.869878292971449 Inf 0 0 0.000176976922618654 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4095 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala104Thr dnaA_p.Ala104Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 1 8 20845 27460 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.99970875200233 0.999426206431739 0.999874251669172 0.111111111111111 0.00280913674659921 0.482496514917337 0 0 0.4592581264399 0 0 0.369416647552819 0 0 1.11898141216371 0.0402093104308738 185 5574 False False 0.164667786039817 0.00371513512243138 1.22846047298172 0 0 0.000176951454458875 0.99970875200233 0.999426206431739 0.999874251669172 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 1 6 13373 21307 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999718481677849 0.999387354605726 0.999896680954833 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.602364635616474 0 0 0.4592581264399 0 0 2.41415795705756 0.305473914118518 456.5 4479 False False 0 0 0 0 0 0 0 0.265547496198808 0.00577686092206708 2.18912593855065 0 0 0.000275807277411719 0.999718481677849 0.999387354605726 0.999896680954833 3 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala108Thr dnaA_p.Ala108Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala108Val dnaA_p.Ala108Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala120Pro dnaA_p.Ala120Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 11 1 10 6 14 20840 27454 0.000287825002398541 0.000105633792978048 0.000626367784710498 0.999490316004077 0.999144984581285 0.999721323894632 0.3 0.118931590405727 0.542789182276289 0.0909090909090909 0.00229897221381426 0.412779916988382 0.0666666666666666 0.0016864302413527 0.319484566578303 0.131737044145873 0.00303970640495875 0.926162814976655 0.0294439674521779 175 5574 False False 0.564587332053742 0.177805311232085 1.56431919273237 4.79823424979607e-05 1.21480699612118e-06 0.000267311181643879 0.999490316004077 0.999144984581285 0.999721323894632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 1 9 3 11 13371 21302 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999483883076056 0.999076712346733 0.999742329032819 0.214285714285714 0.0465792878898673 0.507975677048471 0.1 0.00252857854446178 0.445016117028195 0.0833333333333333 0.00210759323186022 0.384796165150944 0.177016594786395 0.00404246067600667 1.27772922979178 0.100536031167186 193 4479 False False 0 0 0 0 0 0 0 0.43449527811206 0.0778186184798423 1.64518486476369 7.47831289261142e-05 1.89334310623943e-06 0.000416593707936992 0.999483883076056 0.999076712346733 0.999742329032819 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala120Val dnaA_p.Ala120Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.31767810026385 0.0167927522337569 103.35711725526 1 1253.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala137Asp dnaA_p.Ala137Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 14 20846 27454 0 0 0.00017694296670111 0.999490316004077 0.999144984581285 0.999721323894632 0 0 0.231635761650116 0 0 0.602364635616474 0 0 0.231635761650116 0 0 1.99532234121211 0.139081094820667 297 5574 False False 0 0 0.397069295701206 0 0 0.00017694296670111 0.999490316004077 0.999144984581285 0.999721323894632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 13 13374 21300 0 0 0.000275786657608973 0.99939004363534 0.998957181904114 0.999675185224884 0 0 0.24705263800047 0 0 0.707598226178713 0 0 0.24705263800047 0 0 3.85470856547832 0.289191147014053 278 4479 False False 0 0 0 0 0 0 0 0 0 0.522684266329562 0 0 0.000275786657608973 0.99939004363534 0.998957181904114 0.999675185224884 2 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala137Pro dnaA_p.Ala137Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5074 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4076 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala137Val dnaA_p.Ala137Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 7 20843 27461 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999745158002038 0.999474999027776 0.999897534357495 0.3 0.0667395111777345 0.652452850059997 0 0 0.975 0 0 0.409616397225003 0 0 51.3445994947535 1 1253.5 5574 False False 0.564650002398887 0.0941990699429094 2.47377675968382 0 0 0.00017696843241753 0.999745158002038 0.999474999027776 0.999897534357495 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 6 13372 21307 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999718481677849 0.999387354605726 0.999896680954833 0.25 0.0318540262499442 0.650855794412824 0 0 0.975 0 0 0.4592581264399 0 0 62.0863601514425 1 1642.5 4479 False False 0 0 0 0 0 0 0 0.531134709342905 0.0524216694068566 2.97088164447145 0 0 0.000275827900298067 0.999718481677849 0.999387354605726 0.999896680954833 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala138Thr dnaA_p.Ala138Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 9 20846 27459 0 0 0.00017694296670111 0.999672346002621 0.99937810218515 0.999850165132458 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 4861 5574 False False 0 0 0.667448724025835 0 0 0.00017694296670111 0.999672346002621 0.99937810218515 0.999850165132458 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 9 13374 21304 0 0 0.000275786657608973 0.999577722516773 0.999198537836033 0.999806890245066 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 3898 4479 False False 0 0 0 0 0 0 0 0 0 0.80720191833017 0 0 0.000275786657608973 0.999577722516773 0.999198537836033 0.999806890245066 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala139Glu dnaA_p.Ala139Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4832 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala15Val dnaA_p.Ala15Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4967 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3984 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala163Thr dnaA_p.Ala163Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala181Gly dnaA_p.Ala181Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 8 3 20838 27465 0.000383766669864722 0.000165697303700768 0.000756032532322191 0.999890782000873 0.99968085216583 0.999977476056514 0.727272727272727 0.390257440427578 0.939782265827093 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4833 5574 False False 3.51473269987522 0.843433138662064 20.5704549703367 0 0 0.000177010891571197 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 1 13370 21312 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 0.999953080279641 0.999738608085756 0.999998812096234 0.8 0.28358206388191 0.994949236620532 NA NA NA 0 0 0.975 NA NA NA NA 3870 4479 False False 0 0 0 0 0 0 0 6.37606581899775 0.630846560224411 313.513380938872 0 0 0.000275869155324334 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala181Pro dnaA_p.Ala181Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4884 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3917 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala186Pro dnaA_p.Ala186Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 7.01606985634675 0.509383580255417 1109.5 5574 False False 0.439194051331254 0.00837049629364692 5.4704842261679 0 0 0.000176951454458875 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 3 13373 21310 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999859240838924 0.999588697652472 0.999970971136275 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.48558807285294 0.526181327783453 903.5 4479 False False 0 0 0 0 0 0 0 0.531169769934445 0.010122018243966 6.61631049307563 0 0 0.000275807277411719 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala189Gly dnaA_p.Ala189Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala190Val dnaA_p.Ala190Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4825 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3864 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala194Thr dnaA_p.Ala194Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4996 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4010 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala200Thr dnaA_p.Ala200Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4955 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala200Val dnaA_p.Ala200Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala220Ser dnaA_p.Ala220Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 4905 5574 False False Inf 0.869878292971449 Inf 0 0 0.000176976922618654 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3933 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala221Ser dnaA_p.Ala221Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5107 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala221Val dnaA_p.Ala221Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4919 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3945 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala225Gly dnaA_p.Ala225Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4873 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala225Thr dnaA_p.Ala225Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 5 20845 27463 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999817970001456 0.999575254267103 0.999940892797913 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.975 0 0 0.521823750104981 0 0 51.3434130854697 1 2027.5 5574 False False 0.263497241544735 0.00557522895465965 2.35509564487831 0 0 0.000176951454458875 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 5 13373 21308 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999765401398207 0.999452610763328 0.999923822225278 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.975 0 0 0.521823750104981 0 0 62.0846327040722 1 1642.5 4479 False False 0 0 0 0 0 0 0 0.318671950945935 0.00674139558547252 2.84834809554519 0 0 0.000275807277411719 0.999765401398207 0.999452610763328 0.999923822225278 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala257Gly dnaA_p.Ala257Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala257Ser dnaA_p.Ala257Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 5 2 20841 27466 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.999927188000582 0.999737003036386 0.999991182007438 0.714285714285714 0.290420863737342 0.963307433823914 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01767196366986 0.509398939450249 1198.5 5574 False False 3.29470754762247 0.539313466840718 34.60579842565 0 0 0.000176985413634466 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 1 13371 21312 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999953080279641 0.999738608085756 0.999998812096234 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 62.1055547471297 1 1642.5 4479 False False 0 0 0 0 0 0 0 4.78169172088849 0.383875689805931 250.696170545132 0 0 0.000275848526268708 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala257Thr dnaA_p.Ala257Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 9 7 20837 27461 0.000431737503597812 0.000197436276106449 0.000819413341228355 0.999745158002038 0.999474999027776 0.999897534357495 0.5625 0.298776899083177 0.802465859467332 0 0 0.4592581264399 0 0 0.409616397225003 0 0 1.11945178266708 0.0402368163326124 216.5 5574 False False 1.6944377789509 0.561401191870697 5.35470098529887 0 0 0.000177019385846931 0.999745158002038 0.999474999027776 0.999897534357495 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 8 7 13366 21306 0.000598175564528189 0.000258283997825234 0.00117830226263269 0.99967156195749 0.999323409938814 0.999867941002665 0.533333333333333 0.265861347277396 0.787333270480692 0 0 0.4592581264399 0 0 0.409616397225003 0 0 1.35410187881093 0.0884969278732826 190 4479 False False 0 0 0 0 0 0 0 1.82176524657446 0.577110136838304 5.90363815458136 0 0 0.000275951702410535 0.99967156195749 0.999323409938814 0.999867941002665 2 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala257Val dnaA_p.Ala257Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 5 1 20841 27467 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.999963594000291 0.999797175631493 0.999999078280314 0.833333333333333 0.358765421002325 0.99578925548551 0 0 0.975 0 0 0.975 0 0 51.360732841256 1 2027.5 5574 False False 6.58965500695744 0.737267067818355 311.215258952954 0 0 0.000176985413634466 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3899 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala296Asp dnaA_p.Ala296Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala312Gly dnaA_p.Ala312Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala346Ser dnaA_p.Ala346Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4874 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala34Thr dnaA_p.Ala34Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5108 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4108 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala352Gly dnaA_p.Ala352Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala352Pro dnaA_p.Ala352Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 4 2 20842 27466 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999927188000582 0.999737003036386 0.999991182007438 0.666666666666666 0.222778095503512 0.956728131707258 0 0 0.975 0 0 0.841886116991581 0 0 51.3564022799371 1 2027.5 5574 False False 2.63563957393724 0.377684835565828 29.1411399702847 0 0 0.000176976922618654 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 2 13371 21311 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999906160559283 0.999661061221376 0.999988635406343 0.6 0.146632799634673 0.947255049473683 0 0 0.975 0 0 0.841886116991581 0 0 62.1026435994552 1 1642.5 4479 False False 0 0 0 0 0 0 0 2.39073367736145 0.273835790357664 28.6284716983702 0 0 0.000275848526268708 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala352Thr dnaA_p.Ala352Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4862 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala362Gly dnaA_p.Ala362Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4808 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3850 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala362Ser dnaA_p.Ala362Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5063 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala375Thr dnaA_p.Ala375Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 5 0 20841 27468 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 1 0.999865711673152 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 5075 5574 False False Inf 1.20760984683633 Inf 0 0 0.000176985413634466 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4077 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala383Ser dnaA_p.Ala383Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 51.3533466119536 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 62.1009148060541 1 1642.5 4479 False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 0 0 0.000275827900298067 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala38Ser dnaA_p.Ala38Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 51.349017027227 1 2027.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala395Gly dnaA_p.Ala395Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala395Ser dnaA_p.Ala395Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 51.3428199661809 1 2027.5 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 62.0829055149378 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala395Thr dnaA_p.Ala395Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 51.3533466119536 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 62.1009148060541 1 1642.5 4479 False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 0 0 0.000275827900298067 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala395Val dnaA_p.Ala395Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5114 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4113 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala404Asp dnaA_p.Ala404Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5086 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala404Thr dnaA_p.Ala404Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5026 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4037 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala404Val dnaA_p.Ala404Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala406Thr dnaA_p.Ala406Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 2 2 4 2 20842 27466 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999927188000582 0.999737003036386 0.999991182007438 0.666666666666666 0.222778095503512 0.956728131707258 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 1.31781978696862 0.0955370060145441 18.1779986159193 1 2027.5 5574 False False 2.63563957393724 0.377684835565828 29.1411399702847 9.59508731529456e-05 1.16203071146137e-05 0.000346564107961184 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 3 2 13371 21311 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999906160559283 0.999661061221376 0.999988635406343 0.6 0.146632799634673 0.947255049473683 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.796911225787151 0.0135119893749479 15.3098482098533 1 1642.5 4479 False False 0 0 0 0 0 0 0 2.39073367736145 0.273835790357664 28.6284716983702 7.47831289261142e-05 1.89334310623943e-06 0.000416593707936992 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala406Val dnaA_p.Ala406Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 1 6 20845 27462 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999781564001747 0.999524617886493 0.999919833755107 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.11906289991934 0.040214073694581 205 5574 False False 0.219573039098105 0.00477770915407814 1.81014820057657 0 0 0.000176951454458875 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 1 6 13373 21307 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999718481677849 0.999387354605726 0.999896680954833 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.35345678111722 0.0884835334370246 175 4479 False False 0 0 0 0 0 0 0 0.265547496198808 0.00577686092206708 2.18912593855065 0 0 0.000275807277411719 0.999718481677849 0.999387354605726 0.999896680954833 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala413Thr dnaA_p.Ala413Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala419Asp dnaA_p.Ala419Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5050 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4054 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala419Thr dnaA_p.Ala419Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 3.18842099130276 0.264066860104113 431 5574 False False 0 0 1.43785249906968 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 5 13374 21308 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 3.85615642482772 0.289252196403212 283.5 4479 False False 0 0 0 0 0 0 0 0 0 1.73894646374006 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala439Pro dnaA_p.Ala439Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala441Ser dnaA_p.Ala441Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4916 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3942 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala465Glu dnaA_p.Ala465Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4981 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3995 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala465Thr dnaA_p.Ala465Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 1 7 12 14 20834 27454 0.000575650004797083 0.000297481006307132 0.00100532857413147 0.999490316004077 0.999144984581285 0.999721323894632 0.461538461538461 0.265871217422951 0.666291781524707 0.125 0.0031597235312519 0.526509670875206 0.0666666666666666 0.0016864302413527 0.319484566578303 0.188249976000768 0.00418103995332147 1.46553310591707 0.149408323442343 369 5574 False False 1.1294998560046 0.477113671284282 2.63167679892901 4.79961603071754e-05 1.2151568323366e-06 0.000267388152660504 0.999490316004077 0.999144984581285 0.999721323894632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 7 9 13367 21304 0.000523403618962165 0.000210460468745924 0.00107811225334149 0.999577722516773 0.999198537836033 0.999806890245066 0.4375 0.197534140532667 0.701223100916822 0 0 0.707598226178713 0 0 0.336267116879942 0 0 3.85745188193526 0.289306825976681 406 4479 False False 0 0 0 0 0 0 0 1.23960333491267 0.392220305079056 3.74124274425781 0 0 0.000275931061008045 0.999577722516773 0.999198537836033 0.999806890245066 2 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala465Val dnaA_p.Ala465Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 9 9 20837 27459 0.000431737503597812 0.000197436276106449 0.000819413341228355 0.999672346002621 0.99937810218515 0.999850165132458 0.5 0.260190582895097 0.739809417104903 0 0 0.602364635616474 0 0 0.336267116879942 0 0 1.99654610259424 0.139143391095368 357 5574 False False 1.31780006718817 0.463377469353788 3.74736264198833 0 0 0.000177019385846931 0.999672346002621 0.99937810218515 0.999850165132458 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 4 5 13370 21308 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 0.999765401398207 0.999452610763328 0.999923822225278 0.444444444444444 0.136995662265166 0.787991493221131 0 0 0.841886116991581 0 0 0.521823750104981 0 0 8.48669562756263 0.526195481491762 956.5 4479 False False 0 0 0 0 0 0 0 1.27497382198952 0.252954323547563 5.92545609271499 0 0 0.000275869155324334 0.999765401398207 0.999452610763328 0.999923822225278 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala485Thr dnaA_p.Ala485Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala485Val dnaA_p.Ala485Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 5027 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4038 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala80Asp dnaA_p.Ala80Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4982 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3996 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala80Ser dnaA_p.Ala80Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ala85Thr dnaA_p.Ala85Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Arg140Trp dnaA_p.Arg140Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4932 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3955 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Arg154Cys dnaA_p.Arg154Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5004 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4018 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Arg154His dnaA_p.Arg154His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Arg170Cys dnaA_p.Arg170Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5087 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4091 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Arg184Gln dnaA_p.Arg184Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 51.3533466119536 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 62.1009148060541 1 1642.5 4479 False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 0 0 0.000275827900298067 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Arg184Gly dnaA_p.Arg184Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Arg184Trp dnaA_p.Arg184Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4849 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3885 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Arg233Gln dnaA_p.Arg233Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 448 5 20398 27463 0.0214909335124244 0.0195653465822379 0.023551519453248 0.999817970001456 0.999575254267103 0.999940892797913 0.988962472406181 0.974431217877498 0.996406700826451 0 0 0.841886116991581 0 0 0.521823750104981 0 0 7.1693003972768 0.510890128824526 1217 5574 False False 120.633630748112 51.2173078403928 375.953258244916 0 0 0.000180828802639167 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 279 4 13095 21309 0.0208613728129205 0.0185064738859162 0.0234278427096129 0.999812321118566 0.999519537882235 0.999948861529775 0.985865724381625 0.964208053697304 0.99613581263769 0 0 0.841886116991581 0 0 0.602364635616474 0 0 8.66533082223231 0.528497955414018 988 4479 False False 0 0 0 0 0 0 0 113.501546391752 43.8214889124413 417.366592130652 0 0 0.000281661696960629 0.999812321118566 0.999519537882235 0.999948861529775 22 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Arg233Leu dnaA_p.Arg233Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 4 20843 27464 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999854376001165 0.999627187086024 0.999960320981843 0.428571428571428 0.0989882784425078 0.815948432359917 0 0 0.975 0 0 0.602364635616474 0 0 51.3502039740317 1 2027.5 5574 False False 0.988245454109293 0.144734627190883 5.84310835075667 0 0 0.00017696843241753 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4000 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Arg233Pro dnaA_p.Arg233Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 3 5 20843 27463 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999817970001456 0.999575254267103 0.999940892797913 0.375 0.0852334141372535 0.755136783633448 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.43806008939138 0.0743503996915812 270.5 5574 False False 0.790567576644437 0.122780413850952 4.06394022809159 0 0 0.00017696843241753 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 2 5 13372 21308 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999765401398207 0.999452610763328 0.999923822225278 0.285714285714285 0.0366925661760855 0.709579136262657 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.73920648339371 0.16396031861284 265 4479 False False 0 0 0 0 0 0 0 0.637391564463057 0.0606680462541562 3.89402937569226 0 0 0.000275827900298067 0.999765401398207 0.999452610763328 0.999923822225278 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Arg233Trp dnaA_p.Arg233Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 4 3 20842 27465 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999890782000873 0.99968085216583 0.999977476056514 0.571428571428571 0.184051567640083 0.901011721557492 0 0 0.975 0 0 0.707598226178713 0 0 51.3545340310146 1 2027.5 5574 False False 1.75702907590442 0.297192930207644 11.9979296337129 0 0 0.000176976922618654 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 2 13371 21311 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999906160559283 0.999661061221376 0.999988635406343 0.6 0.146632799634673 0.947255049473683 0 0 0.975 0 0 0.841886116991581 0 0 62.1026435994552 1 1642.5 4479 False False 0 0 0 0 0 0 0 2.39073367736145 0.273835790357664 28.6284716983702 0 0 0.000275848526268708 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Arg254His dnaA_p.Arg254His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5109 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4109 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Arg260His dnaA_p.Arg260His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 1 20843 27467 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999963594000291 0.999797175631493 0.999999078280314 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 51.3558084523276 1 2027.5 5574 False False 3.95341361608213 0.31739219148065 207.323829234655 0 0 0.00017696843241753 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 1 13371 21312 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999953080279641 0.999738608085756 0.999998812096234 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 62.1055547471297 1 1642.5 4479 False False 0 0 0 0 0 0 0 4.78169172088849 0.383875689805931 250.696170545132 0 0 0.000275848526268708 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Arg260Leu dnaA_p.Arg260Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4933 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Arg260Ser dnaA_p.Arg260Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 3 1 20843 27467 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999963594000291 0.999797175631493 0.999999078280314 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 4988 5574 False False 3.95341361608213 0.31739219148065 207.323829234655 0 0 0.00017696843241753 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 3 1 13371 21312 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999953080279641 0.999738608085756 0.999998812096234 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 4001 4479 False False 0 0 0 0 0 0 0 4.78169172088849 0.383875689805931 250.696170545132 0 0 0.000275848526268708 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Arg350dup dnaA_p.Arg350dup 2 inframe_insertion (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4885 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3918 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Arg350Gln dnaA_p.Arg350Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 3 20844 27465 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999890782000873 0.99968085216583 0.999977476056514 0.4 0.0527449505263169 0.853367200365326 0 0 0.975 0 0 0.707598226178713 0 0 51.3496104721628 1 2027.5 5574 False False 0.878430243715217 0.0733354884838472 7.66963698207431 0 0 0.000176959943030976 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 2 13372 21311 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999906160559283 0.999661061221376 0.999988635406343 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 62.0980038756619 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59370326054442 0.115491055908661 21.9865025501046 0 0 0.000275827900298067 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Arg350Trp dnaA_p.Arg350Trp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4834 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3871 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Arg367His dnaA_p.Arg367His 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Arg400Cys dnaA_p.Arg400Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 3 2 20843 27466 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999927188000582 0.999737003036386 0.999991182007438 0.6 0.146632799634673 0.947255049473683 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01699856622015 0.509392482788101 1176.5 5574 False False 1.97663484143357 0.226402568392661 23.6672561646805 0 0 0.00017696843241753 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 62.1009148060541 1 1642.5 4479 False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 0 0 0.000275827900298067 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Arg400Gly dnaA_p.Arg400Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 5 2 20841 27466 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.999927188000582 0.999737003036386 0.999991182007438 0.714285714285714 0.290420863737342 0.963307433823914 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01767196366986 0.509398939450249 1198.5 5574 False False 3.29470754762247 0.539313466840718 34.60579842565 0 0 0.000176985413634466 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 13370 21313 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 1 0.999826933785262 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 4078 4479 False False 0 0 0 0 0 0 0 Inf 1.05210128917758 Inf 0 0 0.000275869155324334 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Arg400His dnaA_p.Arg400His 2 missense_variant (see "Genomic_coordinates" sheet) 1 15 2 13 12 27 20834 27441 0.000575650004797083 0.000297481006307132 0.00100532857413147 0.999017038007863 0.998570161716172 0.99935212504807 0.307692307692307 0.170195902964694 0.475691391541684 0.133333333333333 0.0165759134400836 0.404602696603372 0.0689655172413793 0.00846396225300182 0.227661889944486 0.202634746457344 0.0221991762034111 0.895226571147576 0.0194097614717187 148 5574 False False 0.585389267543438 0.270087726129721 1.19534506748286 9.59877135726627e-05 1.16247688225948e-05 0.00034669715486346 0.999017038007863 0.998570161716172 0.99935212504807 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 13 1 12 5 21 13369 21292 0.000373859727830118 0.000121402023062639 0.000872246401868143 0.999014685872472 0.998494234949238 0.9993899748178 0.192307692307692 0.0655481087367825 0.393505527939321 0.0769230769230769 0.00194562849734675 0.360297435267877 0.0454545454545454 0.00115014752657357 0.228444397667633 0.132719974069364 0.00310864761020752 0.897265814889595 0.0219966574197963 111 4479 False False 0 0 0 0 0 0 0 0.379199925912469 0.11169848299556 1.03368762881895 7.47943156320119e-05 1.89362632857505e-06 0.000416656014965588 0.999014685872472 0.998494234949238 0.9993899748178 3 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Arg400Ser dnaA_p.Arg400Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 14 8 20832 27460 0.000671591672263264 0.000367212509754494 0.00112656023057506 0.99970875200233 0.999426206431739 0.999874251669172 0.636363636363636 0.406576668825646 0.828020562353667 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.772327435586838 0.0121323145405884 132 5574 False False 2.3067876344086 0.902881469106682 6.34790329434479 0 0 0.000177061869457058 0.99970875200233 0.999426206431739 0.999874251669172 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 14 5 13360 21308 0.00104680723792433 0.000572413688832994 0.00175574154681136 0.999765401398207 0.999452610763328 0.999923822225278 0.736842105263157 0.487970654654127 0.908534215092333 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.74076823075014 0.163962341939741 271 4479 False False 0 0 0 0 0 0 0 4.46574850299401 1.51941633463818 15.8458254111965 0 0 0.000276075615707154 0.999765401398207 0.999452610763328 0.999923822225278 2 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Arg432Cys dnaA_p.Arg432Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 18 3 15 27 23 20819 27445 0.00129521251079343 0.000853721301750774 0.00188391092655412 0.999162662006698 0.998743845166008 0.999469127824854 0.54 0.393241976116921 0.681850821431391 0.166666666666666 0.0357850831215746 0.414177491394774 0.115384615384615 0.0244580753179622 0.301540400107567 0.263653393534751 0.048923841942237 0.932210653499255 0.0298809371113022 176 5574 False False 1.54753078813876 0.854089653764825 2.82614321441397 0.000144078378637979 2.97134110739061e-05 0.000420999854214703 0.999162662006698 0.998743845166008 0.999469127824854 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 0 11 7 14 13367 21299 0.000523403618962165 0.000210460468745924 0.00107811225334149 0.999343123914981 0.998898118907794 0.999640834680135 0.333333333333333 0.145876942343096 0.569675482904124 0 0 0.284914152918154 0 0 0.231635761650116 0 0 0.635015090506869 0.00913042818973316 86 4479 False False 0 0 0 0 0 0 0 0.796700830403231 0.27207525914001 2.11011071058283 0 0 0.000275931061008045 0.999343123914981 0.998898118907794 0.999640834680135 12 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Arg432His dnaA_p.Arg432His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5051 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4055 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Arg432Leu dnaA_p.Arg432Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5036 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Arg45Lys dnaA_p.Arg45Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Arg487His dnaA_p.Arg487His 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 1.99604811372315 0.139118032244638 322.5 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.41420404242617 0.305473156458586 444 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Arg488Cys dnaA_p.Arg488Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4826 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3865 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Arg488His dnaA_p.Arg488His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4917 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3943 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Arg502His dnaA_p.Arg502His 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 10 20846 27458 0 0 0.00017694296670111 0.999635940002912 0.999330582956894 0.999825405716755 0 0 0.30849710781876 0 0 0.707598226178713 0 0 0.30849710781876 0 0 3.18784050970332 0.26404850501038 425 5574 False False 0 0 0.58772570736746 0 0 0.00017694296670111 0.999635940002912 0.999330582956894 0.999825405716755 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 10 13374 21303 0 0 0.000275786657608973 0.999530802796415 0.99913729947772 0.999774979505452 0 0 0.30849710781876 0 0 0.707598226178713 0 0 0.30849710781876 0 0 3.85525151268157 0.289214038271518 279 4479 False False 0 0 0 0 0 0 0 0 0 0.710765762832934 0 0 0.000275786657608973 0.999530802796415 0.99913729947772 0.999774979505452 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Arg504Ser dnaA_p.Arg504Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Arg507Cys dnaA_p.Arg507Cys 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 13 62 20833 27406 0.000623620838530173 0.000332092285535748 0.00106617452923529 0.997742828018057 0.997107328463502 0.998269014702526 0.173333333333333 0.0956506209378927 0.278148716045801 NA NA NA 0 0 0.0577626344292909 NA NA NA NA 4816 5574 False False 0.275832542352935 0.139102564797899 0.507086315105226 0 0 0.00017705337110378 0.997742828018057 0.997107328463502 0.998269014702526 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 8 51 13366 21262 0.000598175564528189 0.000258283997825234 0.00117830226263269 0.997607094261718 0.996854956319785 0.998217821389018 0.135593220338983 0.0604035139608109 0.249804032335899 NA NA NA 0 0 0.0697770307495386 NA NA NA NA 3857 4479 False False 0 0 0 0 0 0 0 0.24952982839103 0.102221824536609 0.529935512538203 0 0 0.000275951702410535 0.997607094261718 0.996854956319785 0.998217821389018 14 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Arg507His dnaA_p.Arg507His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Arg79Leu dnaA_p.Arg79Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Arg89Gln dnaA_p.Arg89Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asn118Ser dnaA_p.Asn118Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5005 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4019 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asn130Asp dnaA_p.Asn130Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4956 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asn143Asp dnaA_p.Asn143Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4920 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3946 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asn143Lys dnaA_p.Asn143Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 2 2 20844 27466 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999927188000582 0.999737003036386 0.999991182007438 0.5 0.067585986488543 0.932414013511457 0.5 0.012579117093425 0.987420882906574 0.333333333333333 0.00840375865961264 0.905700675949754 1.3176933410094 0.0167929463371296 103.358311851004 1 2027.5 5574 False False 1.3176933410094 0.0955278435529395 18.1762534351792 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4066 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asn143Ser dnaA_p.Asn143Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4997 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4011 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asn157Thr dnaA_p.Asn157Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asn169Ser dnaA_p.Asn169Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 5037 5574 False False Inf 0.869878292971449 Inf 0 0 0.000176976922618654 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4045 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asn223Lys dnaA_p.Asn223Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 7.01573328293188 0.509380354735251 864 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.48495357236853 0.526173219289417 690 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asn223Ser dnaA_p.Asn223Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4968 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asn223Thr dnaA_p.Asn223Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4934 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3956 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asn291Asp dnaA_p.Asn291Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5088 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4092 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asn297Ser dnaA_p.Asn297Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asn297Thr dnaA_p.Asn297Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 1 20843 27467 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999963594000291 0.999797175631493 0.999999078280314 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 51.3558084523276 1 2027.5 5574 False False 3.95341361608213 0.31739219148065 207.323829234655 0 0 0.00017696843241753 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 62.1009148060541 1 1642.5 4479 False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 0 0 0.000275827900298067 0.999953080279641 0.999738608085756 0.999998812096234 2 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asn35Ile dnaA_p.Asn35Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5006 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asn386Ser dnaA_p.Asn386Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 2 3 20844 27465 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999890782000873 0.99968085216583 0.999977476056514 0.4 0.0527449505263169 0.853367200365326 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18895916093986 0.264083883232833 556.5 5574 False False 0.878430243715217 0.0733354884838472 7.66963698207431 0 0 0.000176959943030976 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 2 3 13372 21310 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999859240838924 0.999588697652472 0.999970971136275 0.4 0.0527449505263169 0.853367200365326 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85709530412199 0.289291791934617 400.5 4479 False False 0 0 0 0 0 0 0 1.06241898494366 0.0886985485353837 9.27715037564111 0 0 0.000275827900298067 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asn407Lys dnaA_p.Asn407Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 3 2 20843 27466 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999927188000582 0.999737003036386 0.999991182007438 0.6 0.146632799634673 0.947255049473683 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01699856622015 0.509392482788101 1176.5 5574 False False 1.97663484143357 0.226402568392661 23.6672561646805 0 0 0.00017696843241753 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 2 2 13372 21311 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999906160559283 0.999661061221376 0.999988635406343 0.5 0.067585986488543 0.932414013511457 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.4866208667913 0.526194527956412 951.5 4479 False False 0 0 0 0 0 0 0 1.59370326054442 0.115491055908661 21.9865025501046 0 0 0.000275827900298067 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asn49Lys dnaA_p.Asn49Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4835 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3872 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asn49Ser dnaA_p.Asn49Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp109Ala dnaA_p.Asp109Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp109Asn dnaA_p.Asp109Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4948 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3968 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp109Glu dnaA_p.Asp109Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4921 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3947 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp110Asn dnaA_p.Asp110Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp110Gly dnaA_p.Asp110Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4906 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3934 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp110Tyr dnaA_p.Asp110Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp125Gly dnaA_p.Asp125Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4907 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp125His dnaA_p.Asp125His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4839 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3876 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp131Asn dnaA_p.Asp131Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 51.349017027227 1 2027.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 62.0933648450895 1 1642.5 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp131Tyr dnaA_p.Asp131Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 2 2 20844 27466 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999927188000582 0.999737003036386 0.999991182007438 0.5 0.067585986488543 0.932414013511457 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01666191595533 0.509389255488555 1161.5 5574 False False 1.3176933410094 0.0955278435529395 18.1762534351792 0 0 0.000176959943030976 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 2 2 13372 21311 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999906160559283 0.999661061221376 0.999988635406343 0.5 0.067585986488543 0.932414013511457 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.4866208667913 0.526194527956412 951.5 4479 False False 0 0 0 0 0 0 0 1.59370326054442 0.115491055908661 21.9865025501046 0 0 0.000275827900298067 0.999906160559283 0.999661061221376 0.999988635406343 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp134Asn dnaA_p.Asp134Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp134His dnaA_p.Asp134His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4817 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3858 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp134Tyr dnaA_p.Asp134Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp135Asn dnaA_p.Asp135Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp142Asn dnaA_p.Asp142Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 28 0 28 9 35 20837 27433 0.000431737503597812 0.000197436276106449 0.000819413341228355 0.998725790010193 0.998228323594761 0.999112310547048 0.204545454545454 0.098043176360591 0.353045056778249 0 0 0.123436118500263 0 0 0.100032435572105 0 0 0.185420412716872 1.7661532613478e-07 27 5574 True False 0.338542016605077 0.143077940958094 0.718659772782486 0 0 0.000177019385846931 0.998725790010193 0.998228323594761 0.999112310547048 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 28 0 28 9 34 13365 21279 0.000672947510094212 0.000307759154923187 0.00127707788784856 0.998404729507812 0.997771476125476 0.998894983644582 0.209302325581395 0.100441146677929 0.360424752094166 0 0 0.123436118500263 0 0 0.102817924259012 0 0 0.224282401424739 1.56280572364633e-06 23 4479 True False 0 0 0 0 0 0 0 0.421449792038027 0.177718255899073 0.897624379615954 0 0 0.000275972346901473 0.998404729507812 0.997771476125476 0.998894983644582 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp159His dnaA_p.Asp159His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5076 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4079 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp175Ala dnaA_p.Asp175Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4922 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3948 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp175Asn dnaA_p.Asp175Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4850 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3886 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp175Gly dnaA_p.Asp175Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5092 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp23Asn dnaA_p.Asp23Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5064 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4067 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp23dup dnaA_p.Asp23dup 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp23Tyr dnaA_p.Asp23Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4863 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3900 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp245Asn dnaA_p.Asp245Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp245Glu dnaA_p.Asp245Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp253Ala dnaA_p.Asp253Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4025 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp253His dnaA_p.Asp253His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 5052 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4056 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp266Asn dnaA_p.Asp266Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 8 0 20838 27468 0.000383766669864722 0.000165697303700768 0.000756032532322191 1 0.999865711673152 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 5065 5574 False False Inf 2.24970730189478 Inf 0 0 0.000177010891571197 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 8 0 13366 21313 0.000598175564528189 0.000258283997825234 0.00117830226263269 1 0.999826933785262 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 4068 4479 False False 0 0 0 0 0 0 0 Inf 2.72130996382454 Inf 0 0 0.000275951702410535 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp266His dnaA_p.Asp266His 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 1 8 20845 27460 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.99970875200233 0.999426206431739 0.999874251669172 0.111111111111111 0.00280913674659921 0.482496514917337 0 0 0.4592581264399 0 0 0.369416647552819 0 0 1.11898141216371 0.0402093104308738 185 5574 False False 0.164667786039817 0.00371513512243138 1.22846047298172 0 0 0.000176951454458875 0.99970875200233 0.999426206431739 0.999874251669172 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 7 13374 21306 0 0 0.000275786657608973 0.99967156195749 0.999323409938814 0.999867941002665 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 1.35329212351292 0.0884801279167955 157 4479 False False 0 0 0 0 0 0 0 0 0 1.10552510564584 0 0 0.000275786657608973 0.99967156195749 0.999323409938814 0.999867941002665 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp27His dnaA_p.Asp27His 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 1.99604811372315 0.139118032244638 322.5 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.41420404242617 0.305473156458586 444 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp28His dnaA_p.Asp28His 2 missense_variant (see "Genomic_coordinates" sheet) 1 55 3 52 20 59 20826 27409 0.000959416674661805 0.000586132014909014 0.00148135424594851 0.997852046017183 0.997230158853038 0.998364488122291 0.253164556962025 0.162005928983492 0.363561722220588 0.0545454545454545 0.0113930062727087 0.151234954766599 0.0483870967741935 0.0100919463109757 0.134961947715069 0.0759285730115462 0.0151407079262629 0.234547152351578 5.00936272152134e-10 17 5574 True False 0.446133988316429 0.254349861836115 0.752105172806932 0.000144029958231312 2.97034249595989e-05 0.000420858388422782 0.997852046017183 0.997230158853038 0.998364488122291 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 40 1 39 11 44 13363 21269 0.000822491401226259 0.000410653977896139 0.00147118664271154 0.997935532304227 0.997229528416783 0.99849956619829 0.2 0.104295916925768 0.329728506287614 0.025 0.000632744932049419 0.131585858482765 0.0222222222222222 0.000562459715402258 0.117704331418294 0.0408111183386196 0.00101205562984092 0.241242777912628 1.04923592093769e-07 13 4479 True False 0 0 0 0 0 0 0 0.397908403801541 0.18526091157303 0.783319820323117 7.4827895839569e-05 1.89447650421177e-06 0.000416843047927529 0.997935532304227 0.997229528416783 0.99849956619829 2 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp316His dnaA_p.Asp316His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4935 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3957 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp33Gly dnaA_p.Asp33Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp355Ala dnaA_p.Asp355Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4840 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3877 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp355Asn dnaA_p.Asp355Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp356Glu dnaA_p.Asp356Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 1.99597553667858 0.139114336996004 304.5 5574 False False 0 0 1.43785249906968 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 5 13374 21308 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 2.41409066157565 0.305475026346142 461 4479 False False 0 0 0 0 0 0 0 0 0 1.73894646374006 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp356Gly dnaA_p.Asp356Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5098 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp356His dnaA_p.Asp356His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4851 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp356Tyr dnaA_p.Asp356Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4969 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3985 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp391Asn dnaA_p.Asp391Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp391Glu dnaA_p.Asp391Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 6 20846 27462 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 5038 5574 False False 0 0 1.11900921779861 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 13374 21307 0 0 0.000275786657608973 0.999718481677849 0.999387354605726 0.999896680954833 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 4046 4479 False False 0 0 0 0 0 0 0 0 0 1.35335561005417 0 0 0.000275786657608973 0.999718481677849 0.999387354605726 0.999896680954833 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp391Gly dnaA_p.Asp391Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp3Ala dnaA_p.Asp3Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp405Ala dnaA_p.Asp405Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 3 7 20843 27461 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999745158002038 0.999474999027776 0.999897534357495 0.3 0.0667395111777345 0.652452850059997 0 0 0.841886116991581 0 0 0.409616397225003 0 0 7.01572123544223 0.509380237815859 849 5574 False False 0.564650002398887 0.0941990699429094 2.47377675968382 0 0 0.00017696843241753 0.999745158002038 0.999474999027776 0.999897534357495 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 3 3 13371 21310 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999859240838924 0.999588697652472 0.999970971136275 0.5 0.118117248757025 0.881882751242974 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.48685735854804 0.526197549940579 959 4479 False False 0 0 0 0 0 0 0 1.59374766285244 0.213424225946693 11.9045637110481 0 0 0.000275848526268708 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp405Asn dnaA_p.Asp405Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 51.3533466119536 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp405Glu dnaA_p.Asp405Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 6 0 20840 27468 0.000287825002398541 0.000105633792978048 0.000626367784710498 1 0.999865711673152 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 5014 5574 False False Inf 1.55167078958407 Inf 0 0 0.000176993905465082 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4026 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp405Gly dnaA_p.Asp405Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 4 20845 27464 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999854376001165 0.999627187086024 0.999960320981843 0.2 0.00505076337946806 0.716417936118089 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.18869006320801 0.264075370383126 529 5574 False False 0.329383545214679 0.00669260119676484 3.32889360843958 0 0 0.000176951454458875 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 62.0933648450895 1 1642.5 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp425Ala dnaA_p.Asp425Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4841 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp425Asn dnaA_p.Asp425Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp456Ala dnaA_p.Asp456Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4864 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp456Asn dnaA_p.Asp456Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp456His dnaA_p.Asp456His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4949 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3969 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp492Asn dnaA_p.Asp492Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 11 9 20835 27459 0.000527679171063993 0.000263444034397523 0.000943967185544106 0.999672346002621 0.99937810218515 0.999850165132458 0.55 0.315278133040548 0.769422103224075 0 0 0.409616397225003 0 0 0.336267116879942 0 0 0.914537118999225 0.0219962805756218 170 5574 False False 1.61079913606911 0.606726538712421 4.39856275487397 0 0 0.000177036376844338 0.999672346002621 0.99937810218515 0.999850165132458 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 8 5 13366 21308 0.000598175564528189 0.000258283997825234 0.00117830226263269 0.999765401398207 0.999452610763328 0.999923822225278 0.615384615384615 0.315777602914063 0.861420661109839 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.73998700770246 0.163961279360641 269 4479 False False 0 0 0 0 0 0 0 2.55071075864132 0.735531513736639 9.91435815312427 0 0 0.000275951702410535 0.999765401398207 0.999452610763328 0.999923822225278 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp492Glu dnaA_p.Asp492Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4957 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp4Ala dnaA_p.Asp4Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 7 3 20839 27465 0.000335795836131632 0.000135017659185429 0.000691744589626827 0.999890782000873 0.99968085216583 0.999977476056514 0.7 0.347547149940002 0.933260488822265 0 0 0.975 0 0 0.707598226178713 0 0 51.3619211398695 1 2027.5 5574 False False 3.07524353375881 0.70193019624619 18.4306658389899 0 0 0.00017700239811062 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 3 13373 21310 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999859240838924 0.999588697652472 0.999970971136275 0.25 0.00630946320970987 0.805879550316756 0 0 0.975 0 0 0.707598226178713 0 0 62.0904541316821 1 1642.5 4479 False False 0 0 0 0 0 0 0 0.531169769934445 0.010122018243966 6.61631049307563 0 0 0.000275807277411719 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp4His dnaA_p.Asp4His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp84Glu dnaA_p.Asp84Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp84Gly dnaA_p.Asp84Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Asp84Tyr dnaA_p.Asp84Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4908 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3935 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Gln144Glu dnaA_p.Gln144Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Gln144Lys dnaA_p.Gln144Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Gln226Arg dnaA_p.Gln226Arg 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5015 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4027 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Gln226Pro dnaA_p.Gln226Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Gln274Glu dnaA_p.Gln274Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Gln310Arg dnaA_p.Gln310Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 5 2 20841 27466 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.999927188000582 0.999737003036386 0.999991182007438 0.714285714285714 0.290420863737342 0.963307433823914 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01767196366986 0.509398939450249 1198.5 5574 False False 3.29470754762247 0.539313466840718 34.60579842565 0 0 0.000176985413634466 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 5 2 13369 21311 0.000373859727830118 0.000121402023062639 0.000872246401868143 0.999906160559283 0.999661061221376 0.999988635406343 0.714285714285714 0.290420863737342 0.963307433823914 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48852531192879 0.526218871049245 973 4479 False False 0 0 0 0 0 0 0 3.98515221781733 0.652287032938702 41.8973624237223 0 0 0.000275889787465637 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Gln310His dnaA_p.Gln310His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4989 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4002 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Gln347Lys dnaA_p.Gln347Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Gln347Pro dnaA_p.Gln347Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Gln410Arg dnaA_p.Gln410Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 7.01573328293188 0.509380354735251 864 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3975 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Gln410Lys dnaA_p.Gln410Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4936 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3958 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Gln442Arg dnaA_p.Gln442Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Gln442His dnaA_p.Gln442His 2 missense_variant (see "Genomic_coordinates" sheet) 1 11 0 11 58 46 20788 27422 0.00278230835651923 0.00211338064309473 0.00359531342928037 0.998325324013397 0.997766841513316 0.998773673863725 0.557692307692307 0.45697220438659 0.6550412354355 0 0 0.284914152918154 0 0 0.0770618270519006 0 0 0.525662594442111 0.00349990560599526 106 5574 False False 1.66324635450217 1.1095374628271 2.50610669131642 0 0 0.000177436606374299 0.998325324013397 0.997766841513316 0.998773673863725 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 37 40 13337 21273 0.00276656198594287 0.00194864015550479 0.00381134478706768 0.998123211185661 0.997445213980087 0.998658866472511 0.48051948051948 0.365177379323902 0.597405199785479 0 0 0.30849710781876 0 0 0.0880973028788023 0 0 0.711733942193865 0.00892293074020621 82 4479 False False 0 0 0 0 0 0 0 1.47540863762465 0.917004171208375 2.36811947349608 0 0 0.000276551649377767 0.998123211185661 0.997445213980087 0.998658866472511 3 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Gln464Arg dnaA_p.Gln464Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4958 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3976 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Gln464Lys dnaA_p.Gln464Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5028 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4039 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Gln477His dnaA_p.Gln477His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Gln477Leu dnaA_p.Gln477Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5053 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4057 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Gln503His dnaA_p.Gln503His 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 3 7 20843 27461 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999745158002038 0.999474999027776 0.999897534357495 0.3 0.0667395111777345 0.652452850059997 0 0 0.707598226178713 0 0 0.409616397225003 0 0 3.18864771929711 0.264074029562357 451 5574 False False 0.564650002398887 0.0941990699429094 2.47377675968382 0 0 0.00017696843241753 0.999745158002038 0.999474999027776 0.999897534357495 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 2 6 13372 21307 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999718481677849 0.999387354605726 0.999896680954833 0.25 0.0318540262499442 0.650855794412824 0 0 0.707598226178713 0 0 0.4592581264399 0 0 3.85655227549271 0.289268888036101 379 4479 False False 0 0 0 0 0 0 0 0.531134709342905 0.0524216694068566 2.97088164447145 0 0 0.000275827900298067 0.999718481677849 0.999387354605726 0.999896680954833 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Gln52Glu dnaA_p.Gln52Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Gln52His dnaA_p.Gln52His 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 1 6 20845 27462 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999781564001747 0.999524617886493 0.999919833755107 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.11906289991934 0.040214073694581 205 5574 False False 0.219573039098105 0.00477770915407814 1.81014820057657 0 0 0.000176951454458875 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 1 6 13373 21307 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999718481677849 0.999387354605726 0.999896680954833 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.35345678111722 0.0884835334370246 175 4479 False False 0 0 0 0 0 0 0 0.265547496198808 0.00577686092206708 2.18912593855065 0 0 0.000275807277411719 0.999718481677849 0.999387354605726 0.999896680954833 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Gln71Glu dnaA_p.Gln71Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4865 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3901 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Gln93Pro dnaA_p.Gln93Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4080 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Glu107_Asp109del dnaA_p.Glu107_Asp109del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Glu107Lys dnaA_p.Glu107Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Glu117Asp dnaA_p.Glu117Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Glu117Gly dnaA_p.Glu117Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 51.3446878573018 1 2027.5 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Glu117Lys dnaA_p.Glu117Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Glu132Gln dnaA_p.Glu132Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Glu132Gly dnaA_p.Glu132Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 6 20845 27462 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999781564001747 0.999524617886493 0.999919833755107 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.841886116991581 0 0 0.4592581264399 0 0 7.01530353141229 0.509376235698116 837 5574 False False 0.219573039098105 0.00477770915407814 1.81014820057657 0 0 0.000176951454458875 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 4 13373 21309 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999812321118566 0.999519537882235 0.999948861529775 0.2 0.00505076337946806 0.716417936118089 0 0 0.841886116991581 0 0 0.602364635616474 0 0 8.48518990407669 0.526176238728858 704.5 4479 False False 0 0 0 0 0 0 0 0.398358633066626 0.00809276091420046 4.02622197901862 0 0 0.000275807277411719 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Glu153Asp dnaA_p.Glu153Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Glu153Gly dnaA_p.Glu153Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Glu209Ala dnaA_p.Glu209Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 6 20846 27462 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 0 0 0.4592581264399 0 0 0.841886116991581 0 0 0.4592581264399 0 0 7.01496699475827 0.509373011390968 833.5 5574 False False 0 0 1.11900921779861 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 5 13374 21308 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 3.85615642482772 0.289252196403212 283.5 4479 False False 0 0 0 0 0 0 0 0 0 1.73894646374006 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Glu277Gln dnaA_p.Glu277Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4818 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Glu284Asp dnaA_p.Glu284Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Glu323Ala dnaA_p.Glu323Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5115 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Glu323Gly dnaA_p.Glu323Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4959 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3977 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Glu334Asp dnaA_p.Glu334Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 5110 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4110 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Glu349Gly dnaA_p.Glu349Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Glu359Gln dnaA_p.Glu359Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4886 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Glu366Ala dnaA_p.Glu366Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5066 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4069 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Glu396Asp dnaA_p.Glu396Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 1.99604811372315 0.139118032244638 322.5 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Glu396Gln dnaA_p.Glu396Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Glu396Lys dnaA_p.Glu396Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 36 34 20810 27434 0.00172695001439125 0.00120981863563088 0.00239003299500843 0.998762196009902 0.99827071847151 0.999142637169983 0.514285714285714 0.391726827702855 0.63559784859245 NA NA NA 0 0 0.102817924259012 NA NA NA NA 5016 5574 False False 1.39585606467478 0.848648970987295 2.30042383265733 0 0 0.000177249039850289 0.998762196009902 0.99827071847151 0.999142637169983 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 24 29 13350 21284 0.00179452669358456 0.00115011499978073 0.00266894436176925 0.998639328109604 0.998046428141266 0.999088553203833 0.452830188679245 0.315615283864098 0.595501708273281 NA NA NA 0 0 0.119444869069502 NA NA NA NA 4028 4479 False False 0 0 0 0 0 0 0 1.3194265788454 0.73487737613106 2.34818072529897 0 0 0.000276282385351184 0.998639328109604 0.998046428141266 0.999088553203833 3 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Glu422Gln dnaA_p.Glu422Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5099 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4100 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Glu422Gly dnaA_p.Glu422Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Glu422Lys dnaA_p.Glu422Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 5 2 20841 27466 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.999927188000582 0.999737003036386 0.999991182007438 0.714285714285714 0.290420863737342 0.963307433823914 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01767196366986 0.509398939450249 1198.5 5574 False False 3.29470754762247 0.539313466840718 34.60579842565 0 0 0.000176985413634466 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 5 2 13369 21311 0.000373859727830118 0.000121402023062639 0.000872246401868143 0.999906160559283 0.999661061221376 0.999988635406343 0.714285714285714 0.290420863737342 0.963307433823914 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48852531192879 0.526218871049245 973 4479 False False 0 0 0 0 0 0 0 3.98515221781733 0.652287032938702 41.8973624237223 0 0 0.000275889787465637 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Glu429Ala dnaA_p.Glu429Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4852 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3887 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Glu429Gly dnaA_p.Glu429Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4853 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3888 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Glu429Lys dnaA_p.Glu429Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 4 3 20842 27465 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999890782000873 0.99968085216583 0.999977476056514 0.571428571428571 0.184051567640083 0.901011721557492 0 0 0.975 0 0 0.707598226178713 0 0 51.3545340310146 1 2027.5 5574 False False 1.75702907590442 0.297192930207644 11.9979296337129 0 0 0.000176976922618654 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 2 13372 21311 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999906160559283 0.999661061221376 0.999988635406343 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4093 4479 False False 0 0 0 0 0 0 0 1.59370326054442 0.115491055908661 21.9865025501046 0 0 0.000275827900298067 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Glu430Ala dnaA_p.Glu430Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4923 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Glu430Gln dnaA_p.Glu430Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 2 4 20844 27464 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999854376001165 0.999627187086024 0.999960320981843 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.602364635616474 0 0 0.602364635616474 0 0 1.99623938970482 0.139127771476516 349 5574 False False 0.658798695068125 0.0595601499680727 4.59736120623929 0 0 0.000176959943030976 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 1 4 13373 21309 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999812321118566 0.999519537882235 0.999948861529775 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.41438473582549 0.305470176578709 427 4479 False False 0 0 0 0 0 0 0 0.398358633066626 0.00809276091420046 4.02622197901862 0 0 0.000275807277411719 0.999812321118566 0.999519537882235 0.999948861529775 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Glu430Lys dnaA_p.Glu430Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 5 2 20841 27466 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.999927188000582 0.999737003036386 0.999991182007438 0.714285714285714 0.290420863737342 0.963307433823914 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01767196366986 0.509398939450249 1198.5 5574 False False 3.29470754762247 0.539313466840718 34.60579842565 0 0 0.000176985413634466 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4003 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Glu453Asp dnaA_p.Glu453Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4842 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3878 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Glu483Ala dnaA_p.Glu483Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 6 1 20840 27467 0.000287825002398541 0.000105633792978048 0.000626367784710498 0.999963594000291 0.999797175631493 0.999999078280314 0.857142857142857 0.421276802956804 0.996389703138099 NA NA NA 0 0 0.975 NA NA NA NA 5093 5574 False False 7.90796545105566 0.959277004805377 363.132004070954 0 0 0.000176993905465082 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 4 1 13370 21312 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 0.999953080279641 0.999738608085756 0.999998812096234 0.8 0.28358206388191 0.994949236620532 NA NA NA 0 0 0.975 NA NA NA NA 4096 4479 False False 0 0 0 0 0 0 0 6.37606581899775 0.630846560224411 313.513380938872 0 0 0.000275869155324334 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Glu483Gly dnaA_p.Glu483Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 1 20843 27467 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999963594000291 0.999797175631493 0.999999078280314 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 51.3558084523276 1 2027.5 5574 False False 3.95341361608213 0.31739219148065 207.323829234655 0 0 0.00017696843241753 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4004 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Glu486Ala dnaA_p.Glu486Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 4 1 20842 27467 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999963594000291 0.999797175631493 0.999999078280314 0.8 0.28358206388191 0.994949236620532 0 0 0.975 0 0 0.975 0 0 51.3582705287504 1 2027.5 5574 False False 5.27147106803569 0.521589398427432 259.279173455301 0 0 0.000176976922618654 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 4 1 13370 21312 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 0.999953080279641 0.999738608085756 0.999998812096234 0.8 0.28358206388191 0.994949236620532 0 0 0.975 0 0 0.975 0 0 62.1101953816142 1 1642.5 4479 False False 0 0 0 0 0 0 0 6.37606581899775 0.630846560224411 313.513380938872 0 0 0.000275869155324334 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Glu486Asp dnaA_p.Glu486Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 3 1 20843 27467 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999963594000291 0.999797175631493 0.999999078280314 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 4809 5574 False False 3.95341361608213 0.31739219148065 207.323829234655 0 0 0.00017696843241753 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 3 1 13371 21312 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999953080279641 0.999738608085756 0.999998812096234 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 3851 4479 False False 0 0 0 0 0 0 0 4.78169172088849 0.383875689805931 250.696170545132 0 0 0.000275848526268708 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Glu486fs dnaA_p.Glu486fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Glu486Lys dnaA_p.Glu486Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 1 5 17 7 20829 27461 0.000815504173462534 0.000475130725961031 0.00130538114673077 0.999745158002038 0.999474999027776 0.999897534357495 0.708333333333333 0.489052186142167 0.873847911476308 0.166666666666666 0.00421074451448947 0.641234578997674 0.125 0.0031597235312519 0.526509670875206 0.26368044553267 0.00557910147031007 2.35673319049507 0.245103689599857 418 5574 False False 3.20183398146814 1.26159144759375 9.1332370252621 4.80076812289966e-05 1.21544851646858e-06 0.000267452329043307 0.999745158002038 0.999474999027776 0.999897534357495 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 1 4 14 5 13360 21308 0.00104680723792433 0.000572413688832994 0.00175574154681136 0.999765401398207 0.999452610763328 0.999923822225278 0.736842105263157 0.487970654654127 0.908534215092333 0.2 0.00505076337946806 0.716417936118089 0.166666666666666 0.00421074451448947 0.641234578997674 0.398727544910179 0.00810025008163413 4.02995154438535 0.655154097321201 999 4479 False False 0 0 0 0 0 0 0 4.46574850299401 1.51941633463818 15.8458254111965 7.48446972531996e-05 1.89490187836998e-06 0.000416936627390637 0.999765401398207 0.999452610763328 0.999923822225278 2 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Glu489Ala dnaA_p.Glu489Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 4 2 20842 27466 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999927188000582 0.999737003036386 0.999991182007438 0.666666666666666 0.222778095503512 0.956728131707258 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01733524879011 0.509395710775307 1192 5574 False False 2.63563957393724 0.377684835565828 29.1411399702847 0 0 0.000176976922618654 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 2 2 13372 21311 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999906160559283 0.999661061221376 0.999988635406343 0.5 0.067585986488543 0.932414013511457 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.4866208667913 0.526194527956412 951.5 4479 False False 0 0 0 0 0 0 0 1.59370326054442 0.115491055908661 21.9865025501046 0 0 0.000275827900298067 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Glu489Gln dnaA_p.Glu489Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4875 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Glu489Lys dnaA_p.Glu489Lys 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4998 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4012 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Glu496Ala dnaA_p.Glu496Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4937 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3959 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Glu496Lys dnaA_p.Glu496Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 2 5 20844 27463 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999817970001456 0.999575254267103 0.999940892797913 0.285714285714285 0.0366925661760855 0.709579136262657 0 0 0.841886116991581 0 0 0.521823750104981 0 0 7.01589555425735 0.509381909065137 882 5574 False False 0.527019765879869 0.0501829950712842 3.21985261870185 0 0 0.000176959943030976 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 5 13373 21308 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999765401398207 0.999452610763328 0.999923822225278 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.841886116991581 0 0 0.521823750104981 0 0 8.48479173529998 0.526171149875135 678 4479 False False 0 0 0 0 0 0 0 0.318671950945935 0.00674139558547252 2.84834809554519 0 0 0.000275807277411719 0.999765401398207 0.999452610763328 0.999923822225278 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Glu73Lys dnaA_p.Glu73Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4843 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3879 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Gly141Ala dnaA_p.Gly141Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5111 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Gly164Ser dnaA_p.Gly164Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 3 6 20843 27462 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999781564001747 0.999524617886493 0.999919833755107 0.333333333333333 0.0748546314196918 0.700704943791459 NA NA NA 0 0 0.4592581264399 NA NA NA NA 5017 5574 False False 0.658782325001199 0.106624051224918 3.0850110900601 0 0 0.00017696843241753 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 6 13372 21307 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999718481677849 0.999387354605726 0.999896680954833 0.25 0.0318540262499442 0.650855794412824 NA NA NA 0 0 0.4592581264399 NA NA NA NA 4029 4479 False False 0 0 0 0 0 0 0 0.531134709342905 0.0524216694068566 2.97088164447145 0 0 0.000275827900298067 0.999718481677849 0.999387354605726 0.999896680954833 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Gly222Ala dnaA_p.Gly222Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5007 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Gly22Arg dnaA_p.Gly22Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 5 0 20841 27468 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 1 0.999865711673152 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 5008 5574 False False Inf 1.20760984683633 Inf 0 0 0.000176985413634466 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4020 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Gly231Ala dnaA_p.Gly231Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 4 3 20842 27465 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999890782000873 0.99968085216583 0.999977476056514 0.571428571428571 0.184051567640083 0.901011721557492 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18926519666227 0.264093566162961 563 5574 False False 1.75702907590442 0.297192930207644 11.9979296337129 0 0 0.000176976922618654 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 3 13373 21310 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999859240838924 0.999588697652472 0.999970971136275 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85680682534852 0.289279625558287 389.5 4479 False False 0 0 0 0 0 0 0 0.531169769934445 0.010122018243966 6.61631049307563 0 0 0.000275807277411719 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Gly231Arg dnaA_p.Gly231Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4924 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3949 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Gly231Glu dnaA_p.Gly231Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4970 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3986 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Gly231Val dnaA_p.Gly231Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Gly278Arg dnaA_p.Gly278Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5077 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4081 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Gly433Ala dnaA_p.Gly433Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Gly435Arg dnaA_p.Gly435Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 1 7 20845 27461 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999745158002038 0.999474999027776 0.999897534357495 0.125 0.0031597235312519 0.526509670875206 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.914165078856148 0.0219771744406454 160.5 5574 False False 0.188198608779083 0.00417990056987037 1.46513319151887 0 0 0.000176951454458875 0.999745158002038 0.999474999027776 0.999897534357495 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 7 13374 21306 0 0 0.000275786657608973 0.99967156195749 0.999323409938814 0.999867941002665 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 1.10552510564584 0.0484388314759391 130.5 4479 False False 0 0 0 0 0 0 0 0 0 1.10552510564584 0 0 0.000275786657608973 0.99967156195749 0.999323409938814 0.999867941002665 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Gly463Ala dnaA_p.Gly463Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Gly467Ala dnaA_p.Gly467Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Gly467Arg dnaA_p.Gly467Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 3 20844 27465 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999890782000873 0.99968085216583 0.999977476056514 0.4 0.0527449505263169 0.853367200365326 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4971 5574 False False 0.878430243715217 0.0733354884838472 7.66963698207431 0 0 0.000176959943030976 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 3 13372 21310 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999859240838924 0.999588697652472 0.999970971136275 0.4 0.0527449505263169 0.853367200365326 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3987 4479 False False 0 0 0 0 0 0 0 1.06241898494366 0.0886985485353837 9.27715037564111 0 0 0.000275827900298067 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Gly467Cys dnaA_p.Gly467Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 1 6 12 6 20834 27462 0.000575650004797083 0.000297481006307132 0.00100532857413147 0.999781564001747 0.999524617886493 0.999919833755107 0.666666666666666 0.409925238172074 0.866572597493876 0.142857142857142 0.00361029686190058 0.578723197043195 0.142857142857142 0.00361029686190058 0.578723197043195 0.219688969952961 0.00478022888078829 1.81110218353479 0.251108255833224 420 5574 False False 2.63626763943553 0.915506724708766 8.56198746040087 4.79961603071754e-05 1.2151568323366e-06 0.000267388152660504 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 1 4 12 4 13362 21309 0.000897263346792283 0.000463712283458933 0.00156681338714949 0.999812321118566 0.999519537882235 0.999948861529775 0.75 0.476229180103872 0.927337961747117 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 0.398686573866187 0.00809941836573648 4.02953731456848 0.655151505055357 998 4479 False False 0 0 0 0 0 0 0 4.78423888639425 1.44954602831834 20.3489863060013 7.48334954725735e-05 1.89461827437637e-06 0.000416874236414112 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Gly467Ser dnaA_p.Gly467Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 12 6 20834 27462 0.000575650004797083 0.000297481006307132 0.00100532857413147 0.999781564001747 0.999524617886493 0.999919833755107 0.666666666666666 0.409925238172074 0.866572597493876 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.11965374293991 0.0402486360715506 220 5574 False False 2.63626763943553 0.915506724708766 8.56198746040087 0 0 0.000177044873566246 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 7 6 13367 21307 0.000523403618962165 0.000210460468745924 0.00107811225334149 0.999718481677849 0.999387354605726 0.999896680954833 0.538461538461538 0.251345482270303 0.807767558198712 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.35406412621157 0.0884961425289881 189 4479 False False 0 0 0 0 0 0 0 1.8596668412259 0.535016053553351 6.69837153993076 0 0 0.000275931061008045 0.999718481677849 0.999387354605726 0.999896680954833 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Gly467Val dnaA_p.Gly467Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Gly6Ser dnaA_p.Gly6Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 5054 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4058 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Gly8Arg dnaA_p.Gly8Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4909 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3936 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Gly97Ala dnaA_p.Gly97Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 8 4 20838 27464 0.000383766669864722 0.000165697303700768 0.000756032532322191 0.999854376001165 0.999627187086024 0.999960320981843 0.666666666666666 0.348875506418814 0.900753908850416 0 0 0.602364635616474 0 0 0.602364635616474 0 0 1.99681343604173 0.139157014333534 359 5574 False False 2.6359535464056 0.706046221552531 11.9658991281305 0 0 0.000177010891571197 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 5 1 13369 21312 0.000373859727830118 0.000121402023062639 0.000872246401868143 0.999953080279641 0.999738608085756 0.999998812096234 0.833333333333333 0.358765421002325 0.99578925548551 0 0 0.975 0 0 0.975 0 0 62.114836709663 1 1642.5 4479 False False 0 0 0 0 0 0 0 7.97067843518587 0.891722638077622 376.304140424995 0 0 0.000275889787465637 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.His145Arg dnaA_p.His145Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 21 0 21 20 24 20826 27444 0.000959416674661805 0.000586132014909014 0.00148135424594851 0.99912625600699 0.998700215334872 0.99944009803271 0.454545454545454 0.303907113515673 0.611527877527085 0 0 0.161097615219079 0 0 0.142473597722525 0 0 0.253101088034651 7.71790048097369e-06 43 5574 True False 1.09814654758474 0.575137515229891 2.07505487518324 0 0 0.000177112876713918 0.99912625600699 0.998700215334872 0.99944009803271 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 18 0 18 20 21 13354 21292 0.00149543891132047 0.000913684725149316 0.00230864386780147 0.999014685872472 0.998494234949238 0.9993899748178 0.48780487804878 0.328779035771273 0.648657606182584 0 0 0.185301968137852 0 0 0.161097615219079 0 0 0.362729536311599 0.000286836014865692 45 4479 True False 0 0 0 0 0 0 0 1.51850346249028 0.780659310264838 2.94491217897062 0 0 0.000276199640337768 0.999014685872472 0.998494234949238 0.9993899748178 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.His145Asn dnaA_p.His145Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.His145Pro dnaA_p.His145Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.His156Arg dnaA_p.His156Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 13 195 20833 27273 0.000623620838530173 0.000332092285535748 0.00106617452923529 0.992900830056793 0.991835812854191 0.993859478544784 0.0625 0.033695117281434 0.104505668154056 NA NA NA 0 0 0.0187395208302859 NA NA NA NA 5078 5574 False True 0.0872749963999423 0.0456392912465702 0.152824651443098 0 0 0.00017705337110378 0.992900830056793 0.991835812854191 0.993859478544784 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 10 184 13364 21129 0.000747719455660236 0.000358616922835118 0.00137465137870696 0.991366771454042 0.990031919149368 0.992564869458892 0.0515463917525773 0.0249920524032426 0.0927506814309681 NA NA NA 0 0 0.0198486278842017 NA NA NA NA 4082 4479 False True 1 1 1 0 0 0 0 0.0859260114779485 0.0405356234976431 0.161711457876142 0 0 0.000275992994481552 0.991366771454042 0.990031919149368 0.992564869458892 32 5) Not assoc w R New NotAwR yes 5 +Isoniazid dnaA p.His156Asn dnaA_p.His156Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.His187Arg dnaA_p.His187Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4866 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3902 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.His187Gln dnaA_p.His187Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 6 20846 27462 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 1.43779998918648 0.0743349556518805 235.5 5574 False False 0 0 1.11900921779861 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 6 13374 21307 0 0 0.000275786657608973 0.999718481677849 0.999387354605726 0.999896680954833 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 1.73886488920615 0.163959928472831 238.5 4479 False False 0 0 0 0 0 0 0 0 0 1.35335561005417 0 0 0.000275786657608973 0.999718481677849 0.999387354605726 0.999896680954833 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.His294Tyr dnaA_p.His294Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 6 0 20840 27468 0.000287825002398541 0.000105633792978048 0.000626367784710498 1 0.999865711673152 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 4827 5574 False False Inf 1.55167078958407 Inf 0 0 0.000176993905465082 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3866 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.His493Arg dnaA_p.His493Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 5 3 20841 27465 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.999890782000873 0.99968085216583 0.999977476056514 0.625 0.244863216366551 0.914766585862746 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18941823655459 0.264098409175374 567 5574 False False 2.19639172784415 0.427240710906458 14.1452254524229 0 0 0.000176985413634466 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 5 3 13369 21310 0.000373859727830118 0.000121402023062639 0.000872246401868143 0.999859240838924 0.999588697652472 0.999970971136275 0.625 0.244863216366551 0.914766585862746 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85796099950175 0.289328306573868 409.5 4479 False False 0 0 0 0 0 0 0 2.65664347869449 0.516758123120163 17.1115025092299 0 0 0.000275889787465637 0.999859240838924 0.999588697652472 0.999970971136275 2 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.His493Gln dnaA_p.His493Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4876 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3909 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.His493Leu dnaA_p.His493Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4910 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3937 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.His493Tyr dnaA_p.His493Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4854 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3889 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ile100Thr dnaA_p.Ile100Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5009 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4021 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ile179Ser dnaA_p.Ile179Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4938 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ile179Thr dnaA_p.Ile179Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4999 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4013 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ile179Val dnaA_p.Ile179Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5094 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4097 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ile193Val dnaA_p.Ile193Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 2 20844 27466 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999927188000582 0.999737003036386 0.999991182007438 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 51.3514785421127 1 2027.5 5574 False False 1.3176933410094 0.0955278435529395 18.1762534351792 0 0 0.000176959943030976 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ile273Val dnaA_p.Ile273Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4950 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3970 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ile282Thr dnaA_p.Ile282Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 13 0 13 32 23 20814 27445 0.00153506667945888 0.00105021407755197 0.00216637124602793 0.999162662006698 0.998743845166008 0.999469127824854 0.581818181818181 0.441058410576993 0.713454754751 0 0 0.24705263800047 0 0 0.148185128915224 0 0 0.43273481233256 0.000974489438992951 76 5574 False False 1.83455115912784 1.04013240449007 3.28402727427722 0 0 0.000177214979442231 0.999162662006698 0.998743845166008 0.999469127824854 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 20 17 13354 21296 0.00149543891132047 0.000913684725149316 0.00230864386780147 0.999202364753906 0.998723214865585 0.999535281595187 0.54054054054054 0.36921957010654 0.705126871771355 0 0 0.336267116879942 0 0 0.195064322969093 0 0 0.808107361791469 0.0153939572259548 107 4479 False False 0 0 0 0 0 0 0 1.87615078980521 0.933087780777623 3.81491374877076 0 0 0.000276199640337768 0.999202364753906 0.998723214865585 0.999535281595187 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ile302Leu dnaA_p.Ile302Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4877 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3910 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ile302Met dnaA_p.Ile302Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4887 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3919 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ile327Met dnaA_p.Ile327Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 5 0 20841 27468 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 1 0.999865711673152 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 4888 5574 False False Inf 1.20760984683633 Inf 0 0 0.000176985413634466 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 5 0 13369 21313 0.000373859727830118 0.000121402023062639 0.000872246401868143 1 0.999826933785262 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 3920 4479 False False 0 0 0 0 0 0 0 Inf 1.46057233596553 Inf 0 0 0.000275889787465637 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ile361Met dnaA_p.Ile361Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5000 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4014 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ile361Val dnaA_p.Ile361Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ile365Leu dnaA_p.Ile365Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4918 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3944 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ile365Ser dnaA_p.Ile365Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 2 9 20844 27459 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999672346002621 0.99937810218515 0.999850165132458 0.181818181818181 0.0228311982999596 0.517755852360172 0 0 0.4592581264399 0 0 0.336267116879942 0 0 1.11899434969608 0.0402100663742306 187.5 5574 False False 0.292746113989637 0.0307804028975754 1.41460768720699 0 0 0.000176959943030976 0.999672346002621 0.99937810218515 0.999850165132458 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 1 7 13373 21306 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.99967156195749 0.999323409938814 0.999867941002665 0.125 0.0031597235312519 0.526509670875206 0 0 0.602364635616474 0 0 0.409616397225003 0 0 2.41404456774839 0.305475784613248 465 4479 False False 0 0 0 0 0 0 0 0.227601457093717 0.00505385949080816 1.77192833352817 0 0 0.000275807277411719 0.99967156195749 0.999323409938814 0.999867941002665 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ile365Thr dnaA_p.Ile365Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4005 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ile365Val dnaA_p.Ile365Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 4 20845 27464 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999854376001165 0.999627187086024 0.999960320981843 0.2 0.00505076337946806 0.716417936118089 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.18869006320801 0.264075370383126 529 5574 False False 0.329383545214679 0.00669260119676484 3.32889360843958 0 0 0.000176951454458875 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 3 13373 21310 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999859240838924 0.999588697652472 0.999970971136275 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.48558807285294 0.526181327783453 903.5 4479 False False 0 0 0 0 0 0 0 0.531169769934445 0.010122018243966 6.61631049307563 0 0 0.000275807277411719 0.999859240838924 0.999588697652472 0.999970971136275 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ile377Leu dnaA_p.Ile377Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0337863481185338 Inf 0.431466302367941 667 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ile377Val dnaA_p.Ile377Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ile390Thr dnaA_p.Ile390Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4972 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3988 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ile397Thr dnaA_p.Ile397Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4990 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4006 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ile416Val dnaA_p.Ile416Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5100 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4101 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ile446Leu dnaA_p.Ile446Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4960 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3978 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ile446Met dnaA_p.Ile446Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ile446Val dnaA_p.Ile446Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 2 20844 27466 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999927188000582 0.999737003036386 0.999991182007438 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4844 5574 False False 1.3176933410094 0.0955278435529395 18.1762534351792 0 0 0.000176959943030976 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3880 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ile501Leu dnaA_p.Ile501Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 20 20846 27448 0 0 0.00017694296670111 0.999271880005825 0.998875700613314 0.999555190458412 0 0 0.168433470983085 0 0 0.521823750104981 0 0 0.168433470983085 0 0 1.43706486595685 0.0742913402404196 226 5574 False False 0 0 0.266735414616366 0 0 0.00017694296670111 0.999271880005825 0.998875700613314 0.999555190458412 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 10 13374 21303 0 0 0.000275786657608973 0.999530802796415 0.99913729947772 0.999774979505452 0 0 0.30849710781876 0 0 0.602364635616474 0 0 0.30849710781876 0 0 2.41352375807041 0.305484393035155 468.5 4479 False False 0 0 0 0 0 0 0 0 0 0.710765762832934 0 0 0.000275786657608973 0.999530802796415 0.99913729947772 0.999774979505452 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ile501Val dnaA_p.Ile501Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5039 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4047 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ile56Val dnaA_p.Ile56Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 6 2 20840 27466 0.000287825002398541 0.000105633792978048 0.000626367784710498 0.999927188000582 0.999737003036386 0.999991182007438 0.75 0.349144205587175 0.968145973750055 0 0 0.975 0 0 0.841886116991581 0 0 51.3613269620582 1 2027.5 5574 False False 3.95383877159309 0.706870204411237 40.0621427029589 0 0 0.000176993905465082 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 6 1 13368 21312 0.000448631673396141 0.000164657143425453 0.000976224581517196 0.999953080279641 0.999738608085756 0.999998812096234 0.857142857142857 0.421276802956804 0.996389703138099 NA NA NA 0 0 0.975 NA NA NA NA 3890 4479 False False 0 0 0 0 0 0 0 9.56552962298025 1.16026312817987 439.068355223953 0 0 0.00027591042269331 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ile94Val dnaA_p.Ile94Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01632529799099 0.509386028876591 1135.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48598624162872 0.526186417038858 925 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Leu168Phe dnaA_p.Leu168Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Leu191Phe dnaA_p.Leu191Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 1 4 7 5 20839 27463 0.000335795836131632 0.000135017659185429 0.000691744589626827 0.999817970001456 0.999575254267103 0.999940892797913 0.583333333333333 0.276669685682105 0.848347770191569 0.2 0.00505076337946806 0.716417936118089 0.166666666666666 0.00421074451448947 0.641234578997674 0.329466385143241 0.00669428295095543 3.32973088792522 0.398279363890678 584 5574 False False 1.84501175680214 0.503997297925076 7.37316142205045 4.79846449136276e-05 1.21486528816812e-06 0.000267324007069132 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 5 3 13369 21310 0.000373859727830118 0.000121402023062639 0.000872246401868143 0.999859240838924 0.999588697652472 0.999970971136275 0.625 0.244863216366551 0.914766585862746 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.48812702402024 0.526213778991498 968.5 4479 False False 0 0 0 0 0 0 0 2.65664347869449 0.516758123120163 17.1115025092299 0 0 0.000275889787465637 0.999859240838924 0.999588697652472 0.999970971136275 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Leu228Val dnaA_p.Leu228Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 4 2 20842 27466 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999927188000582 0.999737003036386 0.999991182007438 0.666666666666666 0.222778095503512 0.956728131707258 0 0 0.975 0 0 0.841886116991581 0 0 51.3564022799371 1 2027.5 5574 False False 2.63563957393724 0.377684835565828 29.1411399702847 0 0 0.000176976922618654 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 3 1 13371 21312 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999953080279641 0.999738608085756 0.999998812096234 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 3971 4479 False False 0 0 0 0 0 0 0 4.78169172088849 0.383875689805931 250.696170545132 0 0 0.000275848526268708 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Leu318Met dnaA_p.Leu318Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Leu351Pro dnaA_p.Leu351Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Leu358Val dnaA_p.Leu358Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4961 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3979 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Leu36Ile dnaA_p.Leu36Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 1 8 20845 27460 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.99970875200233 0.999426206431739 0.999874251669172 0.111111111111111 0.00280913674659921 0.482496514917337 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.771845578050951 0.0121121957147065 128 5574 False False 0.164667786039817 0.00371513512243138 1.22846047298172 0 0 0.000176951454458875 0.99970875200233 0.999426206431739 0.999874251669172 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 7 13374 21306 0 0 0.000275786657608973 0.99967156195749 0.999323409938814 0.999867941002665 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 1.10552510564584 0.0484388314759391 130.5 4479 False False 0 0 0 0 0 0 0 0 0 1.10552510564584 0 0 0.000275786657608973 0.99967156195749 0.999323409938814 0.999867941002665 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Leu376Val dnaA_p.Leu376Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.43785249906968 0.0743380732312645 251 5574 False False 0 0 1.43785249906968 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Leu394Met dnaA_p.Leu394Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Leu394Val dnaA_p.Leu394Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 51.3446878573018 1 2027.5 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 62.0858160113928 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Leu399Val dnaA_p.Leu399Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4911 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3938 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Leu402Val dnaA_p.Leu402Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 3 4 20843 27464 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999854376001165 0.999627187086024 0.999960320981843 0.428571428571428 0.0989882784425078 0.815948432359917 0 0 0.841886116991581 0 0 0.602364635616474 0 0 7.01648763390984 0.509387584146166 1155.5 5574 False False 0.988245454109293 0.144734627190883 5.84310835075667 0 0 0.00017696843241753 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 3 4 13371 21309 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999812321118566 0.999519537882235 0.999948861529775 0.428571428571428 0.0989882784425078 0.815948432359917 0 0 0.841886116991581 0 0 0.602364635616474 0 0 8.48645913021433 0.526192459484682 947 4479 False False 0 0 0 0 0 0 0 1.19525465559793 0.17505505093835 7.0663575727929 0 0 0.000275848526268708 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Leu431Phe dnaA_p.Leu431Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 7.01547785354097 0.509377906736075 843 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 62.0858160113928 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Leu440Arg dnaA_p.Leu440Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Leu440Val dnaA_p.Leu440Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4836 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3873 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Leu86Ile dnaA_p.Leu86Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 5112 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4111 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Lys255Asn dnaA_p.Lys255Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Lys298Asn dnaA_p.Lys298Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 3 3 20843 27465 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999890782000873 0.99968085216583 0.999977476056514 0.5 0.118117248757025 0.881882751242974 0 0 0.841886116991581 0 0 0.707598226178713 0 0 7.01674310006514 0.509390033358317 1167.5 5574 False False 1.31770858321738 0.176469385678871 9.83712695959095 0 0 0.00017696843241753 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 2 3 13372 21310 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999859240838924 0.999588697652472 0.999970971136275 0.4 0.0527449505263169 0.853367200365326 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.48622266823901 0.526189438000421 944 4479 False False 0 0 0 0 0 0 0 1.06241898494366 0.0886985485353837 9.27715037564111 0 0 0.000275827900298067 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Lys344Asn dnaA_p.Lys344Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 4912 5574 False False Inf 0.869878292971449 Inf 0 0 0.000176976922618654 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 13370 21313 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 1 0.999826933785262 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3939 4479 False False 0 0 0 0 0 0 0 Inf 1.05210128917758 Inf 0 0 0.000275869155324334 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Lys344Glu dnaA_p.Lys344Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5079 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4083 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Lys387Asn dnaA_p.Lys387Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Lys387Gln dnaA_p.Lys387Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 51.349017027227 1 2027.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3891 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Lys387Thr dnaA_p.Lys387Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4810 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3852 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Lys392Glu dnaA_p.Lys392Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Lys436Arg dnaA_p.Lys436Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4962 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3980 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Lys495Asn dnaA_p.Lys495Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4925 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3950 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Lys506Thr dnaA_p.Lys506Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Met232Arg dnaA_p.Met232Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5095 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Met232Ile dnaA_p.Met232Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 9 7 20837 27461 0.000431737503597812 0.000197436276106449 0.000819413341228355 0.999745158002038 0.999474999027776 0.999897534357495 0.5625 0.298776899083177 0.802465859467332 0 0 0.4592581264399 0 0 0.409616397225003 0 0 1.11945178266708 0.0402368163326124 216.5 5574 False False 1.6944377789509 0.561401191870697 5.35470098529887 0 0 0.000177019385846931 0.999745158002038 0.999474999027776 0.999897534357495 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 5 7 13369 21306 0.000373859727830118 0.000121402023062639 0.000872246401868143 0.99967156195749 0.999323409938814 0.999867941002665 0.416666666666666 0.15165222980843 0.723330314317894 0 0 0.4592581264399 0 0 0.409616397225003 0 0 1.35379810670798 0.0884906085225204 186 4479 False False 0 0 0 0 0 0 0 1.13834777683981 0.2848263848123 4.16756074389191 0 0 0.000275889787465637 0.99967156195749 0.999323409938814 0.999867941002665 2 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Met348Ile dnaA_p.Met348Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 5 10 20841 27458 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.999635940002912 0.999330582956894 0.999825405716755 0.333333333333333 0.11824110336688 0.616196267458845 0 0 0.521823750104981 0 0 0.30849710781876 0 0 1.43793590167339 0.0743430234991833 267 5574 False False 0.658749580154503 0.176664306681793 2.11565922814527 0 0 0.000176985413634466 0.999635940002912 0.999330582956894 0.999825405716755 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 3 9 13371 21304 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999577722516773 0.999198537836033 0.999806890245066 0.25 0.0548606445279927 0.571858461878189 0 0 0.602364635616474 0 0 0.336267116879942 0 0 2.41417917194377 0.305473559789023 455 4479 False False 0 0 0 0 0 0 0 0.531099643507092 0.0924673877284194 2.12867851697681 0 0 0.000275848526268708 0.999577722516773 0.999198537836033 0.999806890245066 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Met348Leu dnaA_p.Met348Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 2 20843 27466 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999927188000582 0.999737003036386 0.999991182007438 0.6 0.146632799634673 0.947255049473683 0 0 0.975 0 0 0.841886116991581 0 0 51.3539402930048 1 2027.5 5574 False False 1.97663484143357 0.226402568392661 23.6672561646805 0 0 0.00017696843241753 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 62.0933648450895 1 1642.5 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Met348Thr dnaA_p.Met348Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4897 5574 False False 0.439194051331254 0.00837049629364692 5.4704842261679 0 0 0.000176951454458875 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 3 13373 21310 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999859240838924 0.999588697652472 0.999970971136275 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3926 4479 False False 0 0 0 0 0 0 0 0.531169769934445 0.010122018243966 6.61631049307563 0 0 0.000275807277411719 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Met409Thr dnaA_p.Met409Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Met417Ile dnaA_p.Met417Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Met417Thr dnaA_p.Met417Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5116 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4114 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Met474Ile dnaA_p.Met474Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 9 6 20837 27462 0.000431737503597812 0.000197436276106449 0.000819413341228355 0.999781564001747 0.999524617886493 0.999919833755107 0.6 0.322869766206281 0.836635676140486 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.11949254214576 0.0402392014663315 218 5574 False False 1.97691606277295 0.62829607236878 6.75185361955151 0 0 0.000177019385846931 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 6 5 13368 21308 0.000448631673396141 0.000164657143425453 0.000976224581517196 0.999765401398207 0.999452610763328 0.999923822225278 0.545454545454545 0.233793597659345 0.832511905936292 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.73972675534077 0.163960947802712 268 4479 False False 0 0 0 0 0 0 0 1.91274685816876 0.486259240069532 7.92430176367559 0 0 0.00027591042269331 0.999765401398207 0.999452610763328 0.999923822225278 2 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Met484Ile dnaA_p.Met484Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 20 8 20826 27460 0.000959416674661805 0.000586132014909014 0.00148135424594851 0.99970875200233 0.999426206431739 0.999874251669172 0.714285714285714 0.513331684551059 0.867763487428874 0 0 0.4592581264399 0 0 0.369416647552819 0 0 1.12000227657943 0.0402690468758141 224 5574 False False 3.29636031883222 1.39044018731342 8.65407279870354 0 0 0.000177112876713918 0.99970875200233 0.999426206431739 0.999874251669172 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 12 6 13362 21307 0.000897263346792283 0.000463712283458933 0.00156681338714949 0.999718481677849 0.999387354605726 0.999896680954833 0.666666666666666 0.409925238172074 0.866572597493876 0 0 0.602364635616474 0 0 0.4592581264399 0 0 2.41614718952628 0.305441261633984 417 4479 False False 0 0 0 0 0 0 0 3.18919323454572 1.10741001039856 10.3589710735326 0 0 0.000276034298911909 0.999718481677849 0.999387354605726 0.999896680954833 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Met484Leu dnaA_p.Met484Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4878 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Phe151Leu dnaA_p.Phe151Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5018 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4030 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Phe229Leu dnaA_p.Phe229Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5019 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4031 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Phe286Leu dnaA_p.Phe286Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5029 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4040 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Phe286Val dnaA_p.Phe286Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 5055 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4059 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Phe466Leu dnaA_p.Phe466Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Phe9Ile dnaA_p.Phe9Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Pro102Leu dnaA_p.Pro102Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 2 3 20844 27465 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999890782000873 0.99968085216583 0.999977476056514 0.4 0.0527449505263169 0.853367200365326 0 0 0.841886116991581 0 0 0.707598226178713 0 0 7.01640646205629 0.50938680646308 1153.5 5574 False False 0.878430243715217 0.0733354884838472 7.66963698207431 0 0 0.000176959943030976 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 4102 4479 False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 0 0 0.000275827900298067 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Pro102Ser dnaA_p.Pro102Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Pro103Ala dnaA_p.Pro103Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Pro103Leu dnaA_p.Pro103Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4939 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3960 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Pro114Leu dnaA_p.Pro114Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Pro119Leu dnaA_p.Pro119Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Pro124Leu dnaA_p.Pro124Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 216 542 20630 26926 0.0103617000863475 0.00903168901581636 0.0118307829768231 0.980267948157856 0.97855329014551 0.981879922453314 0.284960422163588 0.253055489210043 0.318548541577098 NA NA NA 0 0 0.00678294194666273 NA NA NA NA 4973 5574 False True 0.520148173852073 0.441733377031859 0.610792310875513 0 0 0.000178795427382291 0.980267948157856 0.97855329014551 0.981879922453314 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 169 474 13205 20839 0.0126364588006579 0.0108126184575267 0.0146766836859525 0.977760052550086 0.975690443809228 0.979697883559571 0.262830482115085 0.229185105694314 0.298669938102044 NA NA NA 0 0 0.0077522412786346 NA NA NA NA 3989 4479 False True 0 1 1 0 0 0 0 0.562661023745959 0.468569859066443 0.673040114976427 0 0 0.000279315732608401 0.977760052550086 0.975690443809228 0.979697883559571 35 5) Not assoc w R New NotAwR yes 5 +Isoniazid dnaA p.Pro148Leu dnaA_p.Pro148Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5067 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4070 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Pro230Leu dnaA_p.Pro230Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Pro230Ser dnaA_p.Pro230Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Pro24Leu dnaA_p.Pro24Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 129 44 20717 27424 0.00618823755156864 0.00516901885333589 0.00734861544497233 0.998398136012814 0.997850162306153 0.998835849366048 0.745664739884393 0.673995179247073 0.808715138204248 0.333333333333333 0.00840375865961264 0.905700675949754 0.0222222222222222 0.000562459715402258 0.117704331418294 0.661871892648549 0.0112236600384116 12.7154635163785 1 1253.5 5574 False False 3.88097609780285 2.73523137902964 5.5987639966992 4.82672072593879e-05 1.22201913866511e-06 0.000268897997351179 0.998398136012814 0.997850162306153 0.998835849366048 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 19 33 13355 21280 0.00142066696575444 0.000855544226513897 0.00221766232087821 0.99845164922817 0.997826220679006 0.998933954302094 0.365384615384615 0.236243611042711 0.510441043688575 0 0 0.841886116991581 0 0 0.105762810074579 0 0 8.48506416714536 0.526174612665596 702 4479 False False 0 0 0 0 0 0 0 0.917418286194025 0.49265285557226 1.66216858967729 0 0 0.000276178961828104 0.99845164922817 0.997826220679006 0.998933954302094 4 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Pro24Ser dnaA_p.Pro24Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5117 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4115 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Pro307Ala dnaA_p.Pro307Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 5096 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4098 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Pro307Arg dnaA_p.Pro307Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 3 2 20843 27466 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999927188000582 0.999737003036386 0.999991182007438 0.6 0.146632799634673 0.947255049473683 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01699856622015 0.509392482788101 1176.5 5574 False False 1.97663484143357 0.226402568392661 23.6672561646805 0 0 0.00017696843241753 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 62.1009148060541 1 1642.5 4479 False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 0 0 0.000275827900298067 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Pro307Ser dnaA_p.Pro307Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 9 5 20837 27463 0.000431737503597812 0.000197436276106449 0.000819413341228355 0.999817970001456 0.999575254267103 0.999940892797913 0.642857142857142 0.351380110615991 0.87240157014084 0 0 0.975 0 0 0.521823750104981 0 0 51.3631096665522 1 2027.5 5574 False False 2.37238566012381 0.713840715368813 9.0134596352925 0 0 0.000177019385846931 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 8 4 13366 21309 0.000598175564528189 0.000258283997825234 0.00117830226263269 0.999812321118566 0.999519537882235 0.999948861529775 0.666666666666666 0.348875506418814 0.900753908850416 0 0 0.975 0 0 0.602364635616474 0 0 62.120028152237 1 1642.5 4479 False False 0 0 0 0 0 0 0 3.18853808169983 0.853974578957578 14.468701224011 0 0 0.000275951702410535 0.999812321118566 0.999519537882235 0.999948861529775 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Pro307Thr dnaA_p.Pro307Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Pro30His dnaA_p.Pro30His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4951 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3972 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Pro30Thr dnaA_p.Pro30Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4952 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3973 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Pro332Arg dnaA_p.Pro332Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Pro354Ala dnaA_p.Pro354Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01632529799099 0.509386028876591 1135.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Pro354Arg dnaA_p.Pro354Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Pro354Ser dnaA_p.Pro354Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 7 0 20839 27468 0.000335795836131632 0.000135017659185429 0.000691744589626827 1 0.999865711673152 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 5056 5574 False False Inf 1.89951899263229 Inf 0 0 0.00017700239811062 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 7 0 13367 21313 0.000523403618962165 0.000210460468745924 0.00107811225334149 1 0.999826933785262 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 4060 4479 False False 0 0 0 0 0 0 0 Inf 2.29755378883993 Inf 0 0 0.000275931061008045 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Pro389Ser dnaA_p.Pro389Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.18853708762714 0.264070532102877 442 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.48495357236853 0.526173219289417 690 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Pro39Gln dnaA_p.Pro39Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Pro39Leu dnaA_p.Pro39Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Pro42Ser dnaA_p.Pro42Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Pro434Ser dnaA_p.Pro434Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4845 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3881 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Pro460Thr dnaA_p.Pro460Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4983 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3997 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Pro53Leu dnaA_p.Pro53Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5101 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Pro53Ser dnaA_p.Pro53Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4061 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Pro81Leu dnaA_p.Pro81Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ser123Leu dnaA_p.Ser123Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ser136Arg dnaA_p.Ser136Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 11 0 11 0 12 20846 27456 0 0 0.00017694296670111 0.999563128003495 0.99923699702714 0.999774242139628 0 0 0.264648469397051 0 0 0.284914152918154 0 0 0.264648469397051 0 0 0.524850250181136 0.00349739395257092 99 5574 False False 0 0 0.474072891853425 0 0 0.00017694296670111 0.999563128003495 0.99923699702714 0.999774242139628 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 0 11 0 12 13374 21301 0 0 0.000275786657608973 0.999436963355698 0.999016695060306 0.999709037985722 0 0 0.264648469397051 0 0 0.284914152918154 0 0 0.264648469397051 0 0 0.634741511823321 0.00913111943532343 90.5 4479 False False 0 0 0 0 0 0 0 0 0 0.5733410294454 0 0 0.000275786657608973 0.999436963355698 0.999016695060306 0.999709037985722 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ser136Thr dnaA_p.Ser136Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ser146Asn dnaA_p.Ser146Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 5068 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4071 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ser149Gly dnaA_p.Ser149Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ser167Arg dnaA_p.Ser167Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 12 0 12 15 13 20831 27455 0.000719562505996354 0.000402787826414311 0.00118653165660568 0.999526722003786 0.99919081619501 0.999747976101462 0.535714285714285 0.3386990761146 0.724891439703403 0 0 0.264648469397051 0 0 0.24705263800047 0 0 0.474398343100813 0.0018393818090454 85 5574 False False 1.52075493993788 0.67486313040188 3.47361373782197 0 0 0.000177070368626196 0.999526722003786 0.99919081619501 0.999747976101462 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 0 11 9 12 13365 21301 0.000672947510094212 0.000307759154923187 0.00127707788784856 0.999436963355698 0.999016695060306 0.999709037985722 0.428571428571428 0.21819685688513 0.659793690719725 0 0 0.284914152918154 0 0 0.264648469397051 0 0 0.635170204861955 0.00913005167028224 85 4479 False False 0 0 0 0 0 0 0 1.19534231200897 0.444686396803608 3.09193694184834 0 0 0.000275972346901473 0.999436963355698 0.999016695060306 0.999709037985722 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ser167Thr dnaA_p.Ser167Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5069 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4072 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ser210Cys dnaA_p.Ser210Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ser261Asn dnaA_p.Ser261Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 2 11 20844 27457 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999599534003203 0.9992835689522 0.999800072407065 0.153846153846153 0.0192066719825284 0.454471055676557 0 0 0.409616397225003 0 0 0.284914152918154 0 0 0.914075819701885 0.02197259342957 151 5574 False False 0.239502102196402 0.02578903914769 1.09755702800922 0 0 0.000176959943030976 0.999599534003203 0.9992835689522 0.999800072407065 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 1 8 13373 21305 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999624642237132 0.999260530264256 0.999837933676441 0.111111111111111 0.00280913674659921 0.482496514917337 0 0 0.602364635616474 0 0 0.369416647552819 0 0 2.41393117848907 0.30547765625808 467 4479 False False 0 0 0 0 0 0 0 0.199141927764899 0.00449176289276445 1.48571302597227 0 0 0.000275807277411719 0.999624642237132 0.999260530264256 0.999837933676441 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ser261Thr dnaA_p.Ser261Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 3 2 20843 27466 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999927188000582 0.999737003036386 0.999991182007438 0.6 0.146632799634673 0.947255049473683 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01699856622015 0.509392482788101 1176.5 5574 False False 1.97663484143357 0.226402568392661 23.6672561646805 0 0 0.00017696843241753 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 2 2 13372 21311 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999906160559283 0.999661061221376 0.999988635406343 0.5 0.067585986488543 0.932414013511457 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.4866208667913 0.526194527956412 951.5 4479 False False 0 0 0 0 0 0 0 1.59370326054442 0.115491055908661 21.9865025501046 0 0 0.000275827900298067 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ser31Arg dnaA_p.Ser31Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4855 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3892 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ser32Asn dnaA_p.Ser32Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ser32Gly dnaA_p.Ser32Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 10 0 10 6 22 20840 27446 0.000287825002398541 0.000105633792978048 0.000626367784710498 0.999199068006407 0.998787628960307 0.999497994263003 0.214285714285714 0.0829606123876385 0.409531026505828 0 0 0.30849710781876 0 0 0.154372512815574 0 0 0.587637994898217 0.00669304333931813 111 5574 False False 0.359178153899843 0.119123832816213 0.913653387666551 0 0 0.000176993905465082 0.999199068006407 0.998787628960307 0.999497994263003 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 5 22 13369 21291 0.000373859727830118 0.000121402023062639 0.000872246401868143 0.998967766152113 0.998437600176231 0.999352995040555 0.185185185185185 0.0630000065376768 0.380829879093994 0 0 0.30849710781876 0 0 0.154372512815574 0 0 0.710631171712658 0.00888690029041602 73 4479 False False 0 0 0 0 0 0 0 0.361946565664121 0.107064337429134 0.979853120602467 0 0 0.000275889787465637 0.998967766152113 0.998437600176231 0.999352995040555 3 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ser32Ile dnaA_p.Ser32Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4867 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3903 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ser363Arg dnaA_p.Ser363Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18880616510555 0.264079043314886 541.5 5574 False False 0.439194051331254 0.00837049629364692 5.4704842261679 0 0 0.000176951454458875 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 3 13373 21310 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999859240838924 0.999588697652472 0.999970971136275 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85680682534852 0.289279625558287 389.5 4479 False False 0 0 0 0 0 0 0 0.531169769934445 0.010122018243966 6.61631049307563 0 0 0.000275807277411719 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ser363Asn dnaA_p.Ser363Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 2 5 20844 27463 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999817970001456 0.999575254267103 0.999940892797913 0.285714285714285 0.0366925661760855 0.709579136262657 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.43799088572652 0.0743462899699023 268 5574 False False 0.527019765879869 0.0501829950712842 3.21985261870185 0 0 0.000176959943030976 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 1 5 13373 21308 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999765401398207 0.999452610763328 0.999923822225278 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.73907646387712 0.163960168380046 259.5 4479 False False 0 0 0 0 0 0 0 0.318671950945935 0.00674139558547252 2.84834809554519 0 0 0.000275807277411719 0.999765401398207 0.999452610763328 0.999923822225278 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ser363Ile dnaA_p.Ser363Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ser363Thr dnaA_p.Ser363Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 2 7 20844 27461 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999745158002038 0.999474999027776 0.999897534357495 0.222222222222222 0.0281449734778982 0.600093573716312 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.914208921888243 0.0219794248660356 165 5574 False False 0.376415275379005 0.0381509889597215 1.97729867984898 0 0 0.000176959943030976 0.999745158002038 0.999474999027776 0.999897534357495 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 2 5 13372 21308 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999765401398207 0.999452610763328 0.999923822225278 0.285714285714285 0.0366925661760855 0.709579136262657 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.73920648339371 0.16396031861284 265 4479 False False 0 0 0 0 0 0 0 0.637391564463057 0.0606680462541562 3.89402937569226 0 0 0.000275827900298067 0.999765401398207 0.999452610763328 0.999923822225278 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ser364Ile dnaA_p.Ser364Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 2 2 20844 27466 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999927188000582 0.999737003036386 0.999991182007438 0.5 0.067585986488543 0.932414013511457 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01666191595533 0.509389255488555 1161.5 5574 False False 1.3176933410094 0.0955278435529395 18.1762534351792 0 0 0.000176959943030976 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 2 2 13372 21311 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999906160559283 0.999661061221376 0.999988635406343 0.5 0.067585986488543 0.932414013511457 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.4866208667913 0.526194527956412 951.5 4479 False False 0 0 0 0 0 0 0 1.59370326054442 0.115491055908661 21.9865025501046 0 0 0.000275827900298067 0.999906160559283 0.999661061221376 0.999988635406343 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ser364Thr dnaA_p.Ser364Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ser37Thr dnaA_p.Ser37Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4828 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ser384Ala dnaA_p.Ser384Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5097 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4099 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ser412Gly dnaA_p.Ser412Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ser443Thr dnaA_p.Ser443Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ser482Cys dnaA_p.Ser482Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ser505Cys dnaA_p.Ser505Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4879 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3911 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ser505Phe dnaA_p.Ser505Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 5 1 20841 27467 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.999963594000291 0.999797175631493 0.999999078280314 0.833333333333333 0.358765421002325 0.99578925548551 0 0 0.975 0 0 0.975 0 0 51.360732841256 1 2027.5 5574 False False 6.58965500695744 0.737267067818355 311.215258952954 0 0 0.000176985413634466 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 5 0 13369 21313 0.000373859727830118 0.000121402023062639 0.000872246401868143 1 0.999826933785262 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 3912 4479 False False 0 0 0 0 0 0 0 Inf 1.46057233596553 Inf 0 0 0.000275889787465637 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ser505Pro dnaA_p.Ser505Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4856 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ser68Asn dnaA_p.Ser68Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4880 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3913 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ser87Asn dnaA_p.Ser87Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 7.01573328293188 0.509380354735251 864 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ser87Ile dnaA_p.Ser87Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 2 20844 27466 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999927188000582 0.999737003036386 0.999991182007438 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 5040 5574 False False 1.3176933410094 0.0955278435529395 18.1762534351792 0 0 0.000176959943030976 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ter508Gluext*? dnaA_p.Ter508Gluext*? 2 stop_lost (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Ter508Tyrext*? dnaA_p.Ter508Tyrext*? 2 stop_lost (see "Genomic_coordinates" sheet) 1 0 0 0 25 2 20821 27466 0.00119927084332725 0.000776250516059497 0.00176985477840228 0.999927188000582 0.999737003036386 0.999991182007438 0.925925925925926 0.757101653154372 0.990899927057693 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4811 5574 False False 16.4893617021276 4.11062542979143 143.567890655168 0 0 0.0001771554052158 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 25 1 13349 21312 0.00186929863915059 0.00121006548869323 0.00275822519578355 0.999953080279641 0.999738608085756 0.999998812096234 0.961538461538461 0.803630353237461 0.999026712106664 NA NA NA 0 0 0.975 NA NA NA NA 3853 4479 False False 0 0 0 0 0 0 0 39.9131021050265 6.53144612663667 1625.93257971612 0 0 0.000276303079351708 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Thr10Ser dnaA_p.Thr10Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 9 0 9 24 10 20822 27458 0.00115130000959416 0.000737794566721317 0.00171256196858956 0.999635940002912 0.999330582956894 0.999825405716755 0.705882352941176 0.525218939659514 0.849016335576971 0 0 0.336267116879942 0 0 0.30849710781876 0 0 0.668193732344767 0.0128580426042732 134 5574 False False 3.1648832965133 1.45837861928384 7.41740043158217 0 0 0.000177146897881585 0.999635940002912 0.999330582956894 0.999825405716755 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 21 9 13353 21304 0.00157021085688649 0.000972239812025402 0.00239923787401666 0.999577722516773 0.999198537836033 0.999806890245066 0.7 0.506040958537446 0.852654815245299 0 0 0.369416647552819 0 0 0.336267116879942 0 0 0.934863812039029 0.0270692600002009 124 4479 False False 0 0 0 0 0 0 0 3.72270900421877 1.63388320224602 9.23434919464831 0 0 0.000276220321944213 0.999577722516773 0.999198537836033 0.999806890245066 2 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Thr111Asn dnaA_p.Thr111Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Thr112Ala dnaA_p.Thr112Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Thr112del dnaA_p.Thr112del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Thr112Ile dnaA_p.Thr112Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 7.01547785354097 0.509377906736075 843 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 8.48455543336434 0.526168130935474 674.5 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Thr11Ala dnaA_p.Thr11Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 12 0 12 0 16 20846 27452 0 0 0.00017694296670111 0.99941750400466 0.999054234895718 0.999667017718464 0 0 0.205907214207822 0 0 0.264648469397051 0 0 0.205907214207822 0 0 0.474003533995127 0.00183788954087035 82 5574 False False 0 0 0.341525270527104 0 0 0.00017694296670111 0.99941750400466 0.999054234895718 0.999667017718464 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 0 13 13374 21300 0 0 0.000275786657608973 0.99939004363534 0.998957181904114 0.999675185224884 0 0 0.24705263800047 0 0 0.30849710781876 0 0 0.24705263800047 0 0 0.710665706393416 0.00888802582315957 75 4479 False False 0 0 0 0 0 0 0 0 0 0.522684266329562 0 0 0.000275786657608973 0.99939004363534 0.998957181904114 0.999675185224884 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Thr11Ile dnaA_p.Thr11Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4898 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3927 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Thr11Lys dnaA_p.Thr11Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Thr11Pro dnaA_p.Thr11Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Thr121Asn dnaA_p.Thr121Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 5102 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4103 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Thr121Ile dnaA_p.Thr121Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Thr122Ile dnaA_p.Thr122Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 1 20843 27467 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999963594000291 0.999797175631493 0.999999078280314 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 51.3558084523276 1 2027.5 5574 False False 3.95341361608213 0.31739219148065 207.323829234655 0 0 0.00017696843241753 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Thr127Ile dnaA_p.Thr127Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 14 0 14 4 22 20842 27446 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999199068006407 0.998787628960307 0.999497994263003 0.153846153846153 0.0435634765389238 0.348678785535361 0 0 0.231635761650116 0 0 0.154372512815574 0 0 0.397029790240683 0.000518387999846074 67 5574 True False 0.239429124756828 0.0599428293269847 0.705132444320292 0 0 0.000176976922618654 0.999199068006407 0.998787628960307 0.999497994263003 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 0 11 4 19 13370 21294 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 0.999108525313189 0.998608200368116 0.999463191365845 0.17391304347826 0.0495076453057934 0.387811889954797 0 0 0.284914152918154 0 0 0.176466911806965 0 0 0.634722751556645 0.00913116442080941 92 4479 False False 0 0 0 0 0 0 0 0.335298980435381 0.0829671180494753 1.00926750045347 0 0 0.000275869155324334 0.999108525313189 0.998608200368116 0.999463191365845 4 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Thr152Ala dnaA_p.Thr152Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5010 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4022 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Thr158Asn dnaA_p.Thr158Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5001 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Thr166Ile dnaA_p.Thr166Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4812 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3854 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Thr176Ala dnaA_p.Thr176Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 1 20843 27467 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999963594000291 0.999797175631493 0.999999078280314 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 51.3558084523276 1 2027.5 5574 False False 3.95341361608213 0.31739219148065 207.323829234655 0 0 0.00017696843241753 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 62.1009148060541 1 1642.5 4479 False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 0 0 0.000275827900298067 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Thr320Asn dnaA_p.Thr320Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5041 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Thr380Ile dnaA_p.Thr380Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5057 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4062 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 2 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Thr388Ala dnaA_p.Thr388Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 5042 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4048 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Thr388Ile dnaA_p.Thr388Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 3 8 20843 27460 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.99970875200233 0.999426206431739 0.999874251669172 0.272727272727272 0.0602177341729066 0.609742559572421 0 0 0.707598226178713 0 0 0.369416647552819 0 0 3.18853160626062 0.264070356723789 434.5 5574 False False 0.494050760447152 0.0844081742669313 2.05877344876832 0 0 0.00017696843241753 0.99970875200233 0.999426206431739 0.999874251669172 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 2 7 13372 21306 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.99967156195749 0.999323409938814 0.999867941002665 0.222222222222222 0.0281449734778982 0.600093573716312 0 0 0.707598226178713 0 0 0.409616397225003 0 0 3.8563712659637 0.289261254005738 302 4479 False False 0 0 0 0 0 0 0 0.455236955685654 0.0461387128464925 2.39147917078199 0 0 0.000275827900298067 0.99967156195749 0.999323409938814 0.999867941002665 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Thr408Ala dnaA_p.Thr408Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4899 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3928 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Thr415Ala dnaA_p.Thr415Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Thr420Ile dnaA_p.Thr420Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4984 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3998 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Thr420Ser dnaA_p.Thr420Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4900 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3929 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Thr426Ala dnaA_p.Thr426Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Thr426Asn dnaA_p.Thr426Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5011 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Thr426Ile dnaA_p.Thr426Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4974 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3990 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Thr427Ser dnaA_p.Thr427Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5070 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Thr437Ala dnaA_p.Thr437Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Thr499Ala dnaA_p.Thr499Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 5 7 20841 27461 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.999745158002038 0.999474999027776 0.999897534357495 0.416666666666666 0.15165222980843 0.723330314317894 0 0 0.521823750104981 0 0 0.409616397225003 0 0 1.43809347067484 0.0743523816273581 272 5574 False False 0.9411736480975 0.235509910105373 3.44544647606457 0 0 0.000176985413634466 0.999745158002038 0.999474999027776 0.999897534357495 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 4 5 13370 21308 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 0.999765401398207 0.999452610763328 0.999923822225278 0.444444444444444 0.136995662265166 0.787991493221131 0 0 0.602364635616474 0 0 0.521823750104981 0 0 2.41481356388114 0.305463114905762 423 4479 False False 0 0 0 0 0 0 0 1.27497382198952 0.252954323547563 5.92545609271499 0 0 0.000275869155324334 0.999765401398207 0.999452610763328 0.999923822225278 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Thr499Ser dnaA_p.Thr499Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Thr55Ile dnaA_p.Thr55Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 5 0 20841 27468 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 1 0.999865711673152 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 5058 5574 False False Inf 1.20760984683633 Inf 0 0 0.000176985413634466 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 5 0 13369 21313 0.000373859727830118 0.000121402023062639 0.000872246401868143 1 0.999826933785262 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 4063 4479 False False 0 0 0 0 0 0 0 Inf 1.46057233596553 Inf 0 0 0.000275889787465637 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Trp147Cys dnaA_p.Trp147Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4926 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3951 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Trp147Ser dnaA_p.Trp147Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4881 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3914 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Trp324Gly dnaA_p.Trp324Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 7.01606985634675 0.509383580255417 1109.5 5574 False False 0.439194051331254 0.00837049629364692 5.4704842261679 0 0 0.000176951454458875 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4084 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Tyr150Cys dnaA_p.Tyr150Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4927 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Val113Ala dnaA_p.Val113Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4963 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3981 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Val165Ile dnaA_p.Val165Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18880616510555 0.264079043314886 541.5 5574 False False 0.439194051331254 0.00837049629364692 5.4704842261679 0 0 0.000176951454458875 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Val165Leu dnaA_p.Val165Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.18853708762714 0.264070532102877 442 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.85633740727807 0.289259828934126 294 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Val17Leu dnaA_p.Val17Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4928 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3952 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Val234Ile dnaA_p.Val234Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 2 2 20844 27466 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999927188000582 0.999737003036386 0.999991182007438 0.5 0.067585986488543 0.932414013511457 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01666191595533 0.509389255488555 1161.5 5574 False False 1.3176933410094 0.0955278435529395 18.1762534351792 0 0 0.000176959943030976 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Val234Leu dnaA_p.Val234Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Val256Leu dnaA_p.Val256Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 3 1 20843 27467 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999963594000291 0.999797175631493 0.999999078280314 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 4857 5574 False False 3.95341361608213 0.31739219148065 207.323829234655 0 0 0.00017696843241753 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 3893 4479 False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 0 0 0.000275827900298067 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Val265Ala dnaA_p.Val265Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 7 1 20839 27467 0.000335795836131632 0.000135017659185429 0.000691744589626827 0.999963594000291 0.999797175631493 0.999999078280314 0.875 0.473490329124793 0.996840276468748 0 0 0.975 0 0 0.975 0 0 51.3656581746512 1 2027.5 5574 False False 9.22640241854215 1.18513781610454 415.029346412368 0 0 0.00017700239811062 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 6 1 13368 21312 0.000448631673396141 0.000164657143425453 0.000976224581517196 0.999953080279641 0.999738608085756 0.999998812096234 0.857142857142857 0.421276802956804 0.996389703138099 0 0 0.975 0 0 0.975 0 0 62.1194787314315 1 1642.5 4479 False False 0 0 0 0 0 0 0 9.56552962298025 1.16026312817987 439.068355223953 0 0 0.00027591042269331 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Val265Ile dnaA_p.Val265Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5020 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4032 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Val26Leu dnaA_p.Val26Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4975 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Val270Ile dnaA_p.Val270Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 17 10 20829 27458 0.000815504173462534 0.000475130725961031 0.00130538114673077 0.999635940002912 0.999330582956894 0.999825405716755 0.629629629629629 0.423679572504296 0.805992841284865 0 0 0.4592581264399 0 0 0.30849710781876 0 0 1.11975941359358 0.0402548219197608 221 5574 False False 2.2410389360987 0.968863606793292 5.47770447622188 0 0 0.000177087369412526 0.999635940002912 0.999330582956894 0.999825405716755 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 5 3 13369 21310 0.000373859727830118 0.000121402023062639 0.000872246401868143 0.999859240838924 0.999588697652472 0.999970971136275 0.625 0.244863216366551 0.914766585862746 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.48812702402024 0.526213778991498 968.5 4479 False False 0 0 0 0 0 0 0 2.65664347869449 0.516758123120163 17.1115025092299 0 0 0.000275889787465637 0.999859240838924 0.999588697652472 0.999970971136275 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Val301Ala dnaA_p.Val301Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 10 1 20836 27467 0.000479708337330902 0.000230061997553563 0.000882023176671562 0.999963594000291 0.999797175631493 0.999999078280314 0.909090909090909 0.587220083011617 0.997701027786185 0 0 0.975 0 0 0.975 0 0 51.3730479462142 1 2027.5 5574 False False 13.1824726435016 1.87489573468025 570.603433894195 0 0 0.000177027880937939 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 5 1 13369 21312 0.000373859727830118 0.000121402023062639 0.000872246401868143 0.999953080279641 0.999738608085756 0.999998812096234 0.833333333333333 0.358765421002325 0.99578925548551 0 0 0.975 0 0 0.975 0 0 62.114836709663 1 1642.5 4479 False False 0 0 0 0 0 0 0 7.97067843518587 0.891722638077622 376.304140424995 0 0 0.000275889787465637 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Val330Ile dnaA_p.Val330Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 10 3 20836 27465 0.000479708337330902 0.000230061997553563 0.000882023176671562 0.999890782000873 0.99968085216583 0.999977476056514 0.769230769230769 0.461868460765959 0.949618926508848 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.19018365641205 0.264122639715563 574 5574 False False 4.39383758878863 1.13112483984661 24.8470458518278 0 0 0.000177027880937939 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 8 3 13366 21310 0.000598175564528189 0.000258283997825234 0.00117830226263269 0.999859240838924 0.999588697652472 0.999970971136275 0.727272727272727 0.390257440427578 0.939782265827093 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.8588270836742 0.289364844486625 413 4479 False False 0 0 0 0 0 0 0 4.25158362013068 1.02017461695649 24.8845961015246 0 0 0.000275951702410535 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Val353Ala dnaA_p.Val353Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 7.01606985634675 0.509383580255417 1109.5 5574 False False 0.439194051331254 0.00837049629364692 5.4704842261679 0 0 0.000176951454458875 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48598624162872 0.526186417038858 925 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Val353Ile dnaA_p.Val353Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 7 2 20839 27466 0.000335795836131632 0.000135017659185429 0.000691744589626827 0.999927188000582 0.999737003036386 0.999991182007438 0.777777777777777 0.399906426283687 0.971855026522101 0 0 0.975 0 0 0.841886116991581 0 0 51.363789657315 1 2027.5 5574 False False 4.61303325495465 0.87817476276209 45.5132476135674 0 0 0.00017700239811062 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 6 2 13368 21311 0.000448631673396141 0.000164657143425453 0.000976224581517196 0.999906160559283 0.999661061221376 0.999988635406343 0.75 0.349144205587175 0.968145973750055 0 0 0.975 0 0 0.841886116991581 0 0 62.1165669317156 1 1642.5 4479 False False 0 0 0 0 0 0 0 4.78254039497307 0.854982288254785 48.451322625226 0 0 0.00027591042269331 0.999906160559283 0.999661061221376 0.999988635406343 2 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Val353Leu dnaA_p.Val353Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 4889 5574 False False Inf 0.869878292971449 Inf 0 0 0.000176976922618654 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3921 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Val357Ile dnaA_p.Val357Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Val379Ile dnaA_p.Val379Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 9 20845 27459 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999672346002621 0.99937810218515 0.999850165132458 0.1 0.00252857854446178 0.445016117028195 0 0 0.707598226178713 0 0 0.336267116879942 0 0 3.18810955374275 0.264057010623147 426 5574 False False 0.146366035020388 0.00334344690875921 1.0564499909134 0 0 0.000176951454458875 0.999672346002621 0.99937810218515 0.999850165132458 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 5 13373 21308 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999765401398207 0.999452610763328 0.999923822225278 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.841886116991581 0 0 0.521823750104981 0 0 8.48479173529998 0.526171149875135 678 4479 False False 0 0 0 0 0 0 0 0.318671950945935 0.00674139558547252 2.84834809554519 0 0 0.000275807277411719 0.999765401398207 0.999452610763328 0.999923822225278 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Val398Met dnaA_p.Val398Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 7 0 20839 27468 0.000335795836131632 0.000135017659185429 0.000691744589626827 1 0.999865711673152 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 5103 5574 False False Inf 1.89951899263229 Inf 0 0 0.00017700239811062 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4104 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Val428Phe dnaA_p.Val428Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5071 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4073 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Val473Ile dnaA_p.Val473Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 4 20845 27464 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999854376001165 0.999627187086024 0.999960320981843 0.2 0.00505076337946806 0.716417936118089 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.18869006320801 0.264075370383126 529 5574 False False 0.329383545214679 0.00669260119676484 3.32889360843958 0 0 0.000176951454458875 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 3 13373 21310 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999859240838924 0.999588697652472 0.999970971136275 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.48558807285294 0.526181327783453 903.5 4479 False False 0 0 0 0 0 0 0 0.531169769934445 0.010122018243966 6.61631049307563 0 0 0.000275807277411719 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Val490Ile dnaA_p.Val490Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5118 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4116 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Val490Leu dnaA_p.Val490Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 4 3 20842 27465 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999890782000873 0.99968085216583 0.999977476056514 0.571428571428571 0.184051567640083 0.901011721557492 0 0 0.975 0 0 0.707598226178713 0 0 51.3545340310146 1 2027.5 5574 False False 1.75702907590442 0.297192930207644 11.9979296337129 0 0 0.000176976922618654 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 4 3 13370 21310 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 0.999859240838924 0.999588697652472 0.999970971136275 0.571428571428571 0.184051567640083 0.901011721557492 0 0 0.975 0 0 0.707598226178713 0 0 62.1043726513707 1 1642.5 4479 False False 0 0 0 0 0 0 0 2.1251558214909 0.359459073814522 14.5112646280518 0 0 0.000275869155324334 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Val494Ile dnaA_p.Val494Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5021 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4033 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Val51Leu dnaA_p.Val51Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4929 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3953 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid dnaA p.Val57Leu dnaA_p.Val57Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4991 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK c.1011G>A glpK_c.1011G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.247471899512553 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.102C>T glpK_c.102C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1035G>A glpK_c.1035G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.658815063564403 0.011171855707321 12.6567401482543 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1045C>T glpK_c.1045C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1050C>T glpK_c.1050C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 5 0 20841 27468 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 1 0.999865711673152 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.20760984683633 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 5 0 13369 21313 0.000373859727830118 0.000121402023062639 0.000872246401868143 1 0.999826933785262 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.46057233596553 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1062C>T glpK_c.1062C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1089G>A glpK_c.1089G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1102C>T glpK_c.1102C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 36 20845 27432 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.998689384010484 0.998186012178885 0.999081897081075 0.027027027027027 0.000684031024694665 0.141603095611158 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.0365555289038138 0.000905234808401125 0.21712210863851 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 19 13374 21294 0 0 0.000275786657608973 0.999108525313189 0.998608200368116 0.999463191365845 0 0 0.176466911806965 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.341256884077743 NA NA NA NA NA NA 11 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1104G>A glpK_c.1104G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1107C>T glpK_c.1107C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1113A>G glpK_c.1113A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1122G>A glpK_c.1122G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1134C>T glpK_c.1134C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1440 3705 19406 23763 0.06907800057565 0.0656718708833186 0.0726048846020251 0.865115771079073 0.861019209800796 0.869134932798767 0.279883381924198 0.267646657800255 0.292370280721319 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.475926098234988 0.446246056513603 0.507404954551449 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 945 3021 12429 18292 0.0706594885598923 0.0663728705758401 0.0751340288705531 0.858255524797072 0.853500611982503 0.862912496763432 0.238275340393343 0.225086931455428 0.251850407027463 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 0 0.460369017169459 0.426025374647898 0.497210156710182 NA NA NA NA NA NA 640 5) Not assoc w R Now listed Silent mutation no 0 +Isoniazid glpK c.1137C>T glpK_c.1137C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1161C>T glpK_c.1161C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1164C>T glpK_c.1164C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1177C>T glpK_c.1177C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1179G>A glpK_c.1179G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.117G>C glpK_c.117G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 6 0 20840 27468 0.000287825002398541 0.000105633792978048 0.000626367784710498 1 0.999865711673152 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.55167078958407 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.-11G>T glpK_c.-11G>T 2 upstream_gene_variant 4139766 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK c.1200G>C glpK_c.1200G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1209C>T glpK_c.1209C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.99604811372315 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.85651838973546 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.120C>T glpK_c.120C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.247471899512553 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1215C>T glpK_c.1215C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1233C>T glpK_c.1233C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.123C>A glpK_c.123C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 11 24 20835 27444 0.000527679171063993 0.000263444034397523 0.000943967185544106 0.99912625600699 0.998700215334872 0.99944009803271 0.314285714285714 0.168517150747002 0.492880000315174 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.603719702423806 0.266912776060374 1.2805596134641 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 6 14 13368 21299 0.000448631673396141 0.000164657143425453 0.000976224581517196 0.999343123914981 0.998898118907794 0.999640834680135 0.3 0.118931590405727 0.542789182276289 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.682835342395486 0.215017003889834 1.89209016910456 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1245C>T glpK_c.1245C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1257C>G glpK_c.1257C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 7 0 20839 27468 0.000335795836131632 0.000135017659185429 0.000691744589626827 1 0.999865711673152 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.89951899263229 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1257C>T glpK_c.1257C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1260G>A glpK_c.1260G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 2 20844 27466 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999927188000582 0.999737003036386 0.999991182007438 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.3176933410094 0.0955278435529395 18.1762534351792 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1267T>C glpK_c.1267T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1269G>A glpK_c.1269G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 21 20843 27447 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999235474006116 0.998831576963824 0.999526686034611 0.125 0.0265593149862489 0.323611358188833 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.188120711989636 0.0359255331223503 0.630172266058811 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 17 13371 21296 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999202364753906 0.998723214865585 0.999535281595187 0.15 0.0320709371854637 0.378926826545313 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.281064815425833 0.0527681958929851 0.972010067419768 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1278T>C glpK_c.1278T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1281C>T glpK_c.1281C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1293C>T glpK_c.1293C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1299C>T glpK_c.1299C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.129G>A glpK_c.129G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.-12C>G glpK_c.-12C>G 2 upstream_gene_variant 4139767 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3735 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2986 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK c.1302G>A glpK_c.1302G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1305T>C glpK_c.1305T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1317G>A glpK_c.1317G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.544526627735454 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1329G>A glpK_c.1329G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.63548263289195 0.137183409715989 155.34952410964 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1341G>T glpK_c.1341G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 22 20845 27446 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999199068006407 0.998787628960307 0.999497994263003 0.0434782608695652 0.0011001686304415 0.21948660745348 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.0598486665649054 0.00145442440575038 0.370306731935749 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 20 13373 21293 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.99906160559283 0.998551096167295 0.999426713067202 0.0476190476190476 0.00120488344836351 0.238159909936821 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.079611904583863 0.00192485095517253 0.497885128550182 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1356C>A glpK_c.1356C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1372C>T glpK_c.1372C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1383C>T glpK_c.1383C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1395C>T glpK_c.1395C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.-13A>G glpK_c.-13A>G 2 upstream_gene_variant 4139768 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3620 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK c.1401G>A glpK_c.1401G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.141G>A glpK_c.141G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1422G>A glpK_c.1422G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1428T>C glpK_c.1428T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1437C>G glpK_c.1437C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1446A>C glpK_c.1446A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 13 0 20833 27468 0.000623620838530173 0.000332092285535748 0.00106617452923529 1 0.999865711673152 1 1 0.752947361999529 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 4.01743988819503 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 13 0 13361 21313 0.000972035292358307 0.000517666151348512 0.00166163634851859 1 0.999826933785262 1 1 0.752947361999529 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 4.85999660216436 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1452C>T glpK_c.1452C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1464A>G glpK_c.1464A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1470G>A glpK_c.1470G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1488T>C glpK_c.1488T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 23 20846 27445 0 0 0.00017694296670111 0.999162662006698 0.998743845166008 0.999469127824854 0 0 0.148185128915224 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.229082018740918 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 23 13374 21290 0 0 0.000275786657608973 0.998920846431755 0.998381177107211 0.999315790080537 0 0 0.148185128915224 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.277001094079837 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1491C>G glpK_c.1491C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1497T>G glpK_c.1497T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1503C>T glpK_c.1503C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1506C>A glpK_c.1506C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1527G>A glpK_c.1527G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.869878292971449 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1530C>T glpK_c.1530C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.153C>T glpK_c.153C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1542T>A glpK_c.1542T>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1542T>C glpK_c.1542T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.439194051331254 0.00837049629364692 5.4704842261679 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1545C>T glpK_c.1545C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1551C>A glpK_c.1551C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1551C>G glpK_c.1551C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.1551C>T glpK_c.1551C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 7 10 20839 27458 0.000335795836131632 0.000135017659185429 0.000691744589626827 0.999635940002912 0.999330582956894 0.999825405716755 0.411764705882352 0.184436961783946 0.670752846053242 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.922337924084649 0.297924233707181 2.68486556735384 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 7 7 13367 21306 0.000523403618962165 0.000210460468745924 0.00107811225334149 0.99967156195749 0.999323409938814 0.999867941002665 0.5 0.230360541448062 0.769639458551937 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59392533852023 0.476953514422096 5.32651924392031 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.159C>T glpK_c.159C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 8 20843 27460 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.99970875200233 0.999426206431739 0.999874251669172 0.272727272727272 0.0602177341729066 0.609742559572421 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.494050760447152 0.0844081742669313 2.05877344876832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 8 13374 21305 0 0 0.000275786657608973 0.999624642237132 0.999260530264256 0.999837933676441 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.93343997011793 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.189C>T glpK_c.189C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.-18C>T glpK_c.-18C>T 2 upstream_gene_variant 4139773 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3699 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2960 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK c.-19T>C glpK_c.-19T>C 2 upstream_gene_variant 4139774 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3530 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK c.-19T>G glpK_c.-19T>G 2 upstream_gene_variant 4139774 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK c.201C>A glpK_c.201C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.-20A>G glpK_c.-20A>G 2 upstream_gene_variant 4139775 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK c.-21_-20insC glpK_c.-21_-20insC 2 upstream_gene_variant 4139775 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3575 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2869 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK c.219G>A glpK_c.219G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.234C>G glpK_c.234C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 1 20843 27467 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999963594000291 0.999797175631493 0.999999078280314 0.75 0.194120449683243 0.99369053679029 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.95341361608213 0.31739219148065 207.323829234655 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.234C>T glpK_c.234C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.238C>T glpK_c.238C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.246G>A glpK_c.246G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 23 20845 27445 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999162662006698 0.998743845166008 0.999469127824854 0.0416666666666666 0.00105435244546974 0.211201683456973 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.0572444648388206 0.00139393050307766 0.352593694589121 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 20 13373 21293 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.99906160559283 0.998551096167295 0.999426713067202 0.0476190476190476 0.00120488344836351 0.238159909936821 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.079611904583863 0.00192485095517253 0.497885128550182 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.261G>T glpK_c.261G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.264G>A glpK_c.264G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.267G>A glpK_c.267G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.267G>T glpK_c.267G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.27A>G glpK_c.27A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 12 9 20834 27459 0.000575650004797083 0.000297481006307132 0.00100532857413147 0.999672346002621 0.99937810218515 0.999850165132458 0.571428571428571 0.340206309280274 0.781803143114869 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.75731976576749 0.679434182414433 4.72297590915249 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 8 13371 21305 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999624642237132 0.999260530264256 0.999837933676441 0.272727272727272 0.0602177341729066 0.609742559572421 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.597515144716176 0.102061600869156 2.49011680409225 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.288G>A glpK_c.288G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.247471899512553 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.306G>A glpK_c.306G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.309C>T glpK_c.309C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.658815063564403 0.011171855707321 12.6567401482543 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.315A>G glpK_c.315A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.318G>A glpK_c.318G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.330C>T glpK_c.330C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.336T>C glpK_c.336T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.99604811372315 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.41420404242617 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.33C>T glpK_c.33C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.-34C>T glpK_c.-34C>T 2 upstream_gene_variant 4139789 NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3551 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2854 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK c.354C>G glpK_c.354C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.354C>T glpK_c.354C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.360C>T glpK_c.360C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.363C>G glpK_c.363C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.99604811372315 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.41420404242617 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.363C>T glpK_c.363C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.369G>T glpK_c.369G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.-37delC glpK_c.-37delC 2 upstream_gene_variant 4139791 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK c.-38C>T glpK_c.-38C>T 2 upstream_gene_variant 4139793 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK c.39C>G glpK_c.39C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.408C>G glpK_c.408C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.411C>T glpK_c.411C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.414G>A glpK_c.414G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.18865318395302 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.417G>A glpK_c.417G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 25 20845 27443 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999089850007281 0.998656730244862 0.999410915028568 0.0384615384615384 0.00097328789333503 0.196369646762539 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.0526610698009114 0.00128691236011034 0.321741107473799 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 13 13374 21300 0 0 0.000275786657608973 0.99939004363534 0.998957181904114 0.999675185224884 0 0 0.24705263800047 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.522684266329562 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.-41G>A glpK_c.-41G>A 2 upstream_gene_variant 4139796 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3664 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2935 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK c.420C>T glpK_c.420C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.429G>A glpK_c.429G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.435T>A glpK_c.435T>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.99604811372315 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.41420404242617 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.-43C>A glpK_c.-43C>A 2 upstream_gene_variant 4139798 1 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3648 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2922 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK c.-43C>T glpK_c.-43C>T 2 upstream_gene_variant 4139798 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK c.444T>G glpK_c.444T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.658815063564403 0.011171855707321 12.6567401482543 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.450C>A glpK_c.450C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.-46C>T glpK_c.-46C>T 2 upstream_gene_variant 4139801 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3544 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK c.-47_-45delGCG glpK_c.-47_-45delGCG 2 upstream_gene_variant 4139799 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK c.-47G>A glpK_c.-47G>A 2 upstream_gene_variant 4139802 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK c.492G>T glpK_c.492G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.495C>G glpK_c.495C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.63548263289195 0.137183409715989 155.34952410964 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.495C>T glpK_c.495C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 5 20845 27463 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999817970001456 0.999575254267103 0.999940892797913 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.263497241544735 0.00557522895465965 2.35509564487831 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 4 13373 21309 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999812321118566 0.999519537882235 0.999948861529775 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.398358633066626 0.00809276091420046 4.02622197901862 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.510C>T glpK_c.510C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 190 294 20656 27174 0.00911445840928715 0.00786922273239379 0.0104993225274707 0.989296636085626 0.988008360998255 0.99047977283649 0.392561983471074 0.348797225399048 0.437647674384551 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.850185349120283 0.703987555662526 1.02480321479609 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 142 262 13232 21051 0.0106176162703753 0.00895030626898745 0.0125026930068806 0.987707033266081 0.986135830659482 0.989143021526513 0.351485148514851 0.304929875322419 0.40023439787833 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.862252162234509 0.697126827852747 1.06294923055431 NA NA NA NA NA NA 63 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.525A>G glpK_c.525A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 5 3 20841 27465 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.999890782000873 0.99968085216583 0.999977476056514 0.625 0.244863216366551 0.914766585862746 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.19639172784415 0.427240710906458 14.1452254524229 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 2 13372 21311 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999906160559283 0.999661061221376 0.999988635406343 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59370326054442 0.115491055908661 21.9865025501046 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.528G>A glpK_c.528G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.528G>T glpK_c.528G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.54C>T glpK_c.54C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.558C>G glpK_c.558C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.561G>T glpK_c.561G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.570G>A glpK_c.570G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.570G>C glpK_c.570G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.597C>T glpK_c.597C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.-5A>G glpK_c.-5A>G 2 upstream_gene_variant 4139760 1 6 0 6 18 9 20828 27459 0.000863475007195625 0.000511827761943967 0.00136432078973001 0.999672346002621 0.99937810218515 0.999850165132458 0.666666666666666 0.460392713907742 0.834811820312684 0 0 0.4592581264399 0 0 0.336267116879942 0 0 1.11985395251578 0.0402603582999089 222 5574 False False 2.63673900518532 1.12453124876434 6.66387942907276 0 0 0.000177095871029953 0.999672346002621 0.99937810218515 0.999850165132458 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 9 4 13365 21309 0.000672947510094212 0.000307759154923187 0.00127707788784856 0.999812321118566 0.999519537882235 0.999948861529775 0.692307692307692 0.385738338249294 0.909079605427903 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.85893476040329 0.289369386674439 414 4479 False False 0 0 0 0 0 0 0 3.58737373737373 1.00094889844823 15.9392662427084 0 0 0.000275972346901473 0.999812321118566 0.999519537882235 0.999948861529775 2 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK c.609C>T glpK_c.609C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.60C>T glpK_c.60C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.624A>C glpK_c.624A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 17 3 20829 27465 0.000815504173462534 0.000475130725961031 0.00130538114673077 0.999890782000873 0.99968085216583 0.999977476056514 0.85 0.621073173454686 0.967929062814536 NA NA NA NA NA NA NA NA NA NA NA NA False False 7.47203418311008 2.16072515121461 39.8011112481045 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 7 2 13367 21311 0.000523403618962165 0.000210460468745924 0.00107811225334149 0.999906160559283 0.999661061221376 0.999988635406343 0.777777777777777 0.399906426283687 0.971855026522101 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 5.58004787910525 1.06221404733015 55.0152654432543 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.63C>T glpK_c.63C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.645C>T glpK_c.645C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.439194051331254 0.00837049629364692 5.4704842261679 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.649C>T glpK_c.649C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 7 0 20839 27468 0.000335795836131632 0.000135017659185429 0.000691744589626827 1 0.999865711673152 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.89951899263229 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 7 0 13367 21313 0.000523403618962165 0.000210460468745924 0.00107811225334149 1 0.999826933785262 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 2.29755378883993 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.658T>C glpK_c.658T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.6C>G glpK_c.6C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.702G>C glpK_c.702G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.708G>A glpK_c.708G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.708G>T glpK_c.708G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.717T>C glpK_c.717T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.717T>G glpK_c.717T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.726C>T glpK_c.726C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.658815063564403 0.011171855707321 12.6567401482543 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.741G>T glpK_c.741G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 18 23 20828 27445 0.000863475007195625 0.000511827761943967 0.00136432078973001 0.999162662006698 0.998743845166008 0.999469127824854 0.439024390243902 0.284687076807925 0.60250156261924 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.03124138909995 0.524278335878902 1.99779063302063 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 18 20 13356 21293 0.00134589502018842 0.000797851614369596 0.00212626349435784 0.99906160559283 0.998551096167295 0.999426713067202 0.473684210526315 0.309807301608208 0.641816563739496 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.43483827493261 0.7153239863917 2.8578546801999 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.747C>G glpK_c.747C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.759G>A glpK_c.759G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.759G>T glpK_c.759G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.75C>A glpK_c.75C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.75C>T glpK_c.75C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.762G>A glpK_c.762G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.765C>T glpK_c.765C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.658815063564403 0.011171855707321 12.6567401482543 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.777C>A glpK_c.777C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.777C>T glpK_c.777C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.789T>C glpK_c.789T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 2 20844 27466 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999927188000582 0.999737003036386 0.999991182007438 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.3176933410094 0.0955278435529395 18.1762534351792 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 2 13372 21311 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999906160559283 0.999661061221376 0.999988635406343 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59370326054442 0.115491055908661 21.9865025501046 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.795C>T glpK_c.795C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.-7A>G glpK_c.-7A>G 2 upstream_gene_variant 4139762 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK c.801C>T glpK_c.801C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.810C>T glpK_c.810C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.816G>A glpK_c.816G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.828G>A glpK_c.828G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.843T>C glpK_c.843T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.84C>T glpK_c.84C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.852C>T glpK_c.852C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.859C>T glpK_c.859C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.247471899512553 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.864G>A glpK_c.864G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.873C>T glpK_c.873C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.99604811372315 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.41420404242617 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.87C>T glpK_c.87C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.43785249906968 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 5 13374 21308 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.73894646374006 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.891A>G glpK_c.891A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 4 20842 27464 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999854376001165 0.999627187086024 0.999960320981843 0.5 0.157012770487058 0.842987229512941 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31772382688801 0.245404796089043 7.07564826366186 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 4 1 13370 21312 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 0.999953080279641 0.999738608085756 0.999998812096234 0.8 0.28358206388191 0.994949236620532 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 6.37606581899775 0.630846560224411 313.513380938872 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.-8T>C glpK_c.-8T>C 2 upstream_gene_variant 4139763 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3700 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK c.900C>T glpK_c.900C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 6 20844 27462 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999781564001747 0.999524617886493 0.999919833755107 0.25 0.0318540262499442 0.650855794412824 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.439167146421032 0.0433460282809438 2.45619176778693 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 3 13372 21310 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999859240838924 0.999588697652472 0.999970971136275 0.4 0.0527449505263169 0.853367200365326 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.06241898494366 0.0886985485353837 9.27715037564111 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.906G>A glpK_c.906G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.912C>T glpK_c.912C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.921C>T glpK_c.921C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.936C>T glpK_c.936C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.945C>T glpK_c.945C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.969C>T glpK_c.969C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.96C>T glpK_c.96C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 7 20844 27461 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999745158002038 0.999474999027776 0.999897534357495 0.222222222222222 0.0281449734778982 0.600093573716312 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.376415275379005 0.0381509889597215 1.97729867984898 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 3 13372 21310 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999859240838924 0.999588697652472 0.999970971136275 0.4 0.0527449505263169 0.853367200365326 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.06241898494366 0.0886985485353837 9.27715037564111 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.978C>T glpK_c.978C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.18865318395302 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.99T>C glpK_c.99T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid glpK c.-9T>G glpK_c.-9T>G 2 upstream_gene_variant 4139764 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3693 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2955 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK deletion glpK_deletion 2 feature_ablation (see "Genomic_coordinates" sheet) NA 0 0 0 2 5 20844 27463 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999817970001456 0.999575254267103 0.999940892797913 0.285714285714285 0.0366925661760855 0.709579136262657 NA NA NA 0 0 0.521823750104981 NA NA NA NA 3649 5574 False False 0.527019765879869 0.0501829950712842 3.21985261870185 0 0 0.000176959943030976 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 4 13373 21309 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999812321118566 0.999519537882235 0.999948861529775 0.2 0.00505076337946806 0.716417936118089 NA NA NA 0 0 0.602364635616474 NA NA NA NA 2923 4479 False False 0 0 0 0 0 0 0 0.398358633066626 0.00809276091420046 4.02622197901862 0 0 0.000275807277411719 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK LoF glpK_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 97 4 93 409 220 20437 27248 0.0196200709968339 0.0177805937105152 0.0215951720042638 0.991990680064074 0.990864642034064 0.993010689176049 0.650238473767885 0.611537249526444 0.687521677726532 0.0412371134020618 0.0113482725688341 0.10222746629841 0.0178571428571428 0.00488636932704782 0.045087739367381 0.0573448641800318 0.0152998767348871 0.15186612558274 6.23485753607248e-18 9 5574 True False 2.47866658956349 2.09670037087471 2.93624005592987 0.000195685142605547 5.33201066310307e-05 0.000500955195410038 0.991990680064074 0.990864642034064 0.993010689176049 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 64 2 62 186 150 13188 21163 0.0139075818752803 0.0119917784752545 0.0160389568727903 0.99296204194623 0.991746371161425 0.994040165277003 0.553571428571428 0.498655022534139 0.607535299554213 0.03125 0.00380718138187237 0.108370522224517 0.0131578947368421 0.00159747320161193 0.0467209219722237 0.051765045446985 0.00613952828263513 0.195111392413864 4.51853329704775e-11 10 4479 True False 0 0 0 0 0 0 0 1.9898483469821 1.59418936092503 2.48705508155599 0.000151630022744503 1.83636267337544e-05 0.000547631305890177 0.99296204194623 0.991746371161425 0.994040165277003 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ala111Glu glpK_p.Ala111Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ala11Val glpK_p.Ala11Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 7 20846 27461 0 0 0.00017694296670111 0.999745158002038 0.999474999027776 0.999897534357495 0 0 0.409616397225003 0 0 0.521823750104981 0 0 0.409616397225003 0 0 1.4377474794477 0.0743318383647099 231 5574 False False 0 0 0.914121240039481 0 0 0.00017694296670111 0.999745158002038 0.999474999027776 0.999897534357495 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ala139Val glpK_p.Ala139Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3711 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2970 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ala164Thr glpK_p.Ala164Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 3531 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 2840 4479 False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 0 0 0.000275827900298067 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ala171Val glpK_p.Ala171Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18880616510555 0.264079043314886 541.5 5574 False False 0.439194051331254 0.00837049629364692 5.4704842261679 0 0 0.000176951454458875 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 3 13373 21310 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999859240838924 0.999588697652472 0.999970971136275 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85680682534852 0.289279625558287 389.5 4479 False False 0 0 0 0 0 0 0 0.531169769934445 0.010122018243966 6.61631049307563 0 0 0.000275807277411719 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ala18Thr glpK_p.Ala18Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ala19Val glpK_p.Ala19Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3694 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2956 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ala200Ser glpK_p.Ala200Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ala232Thr glpK_p.Ala232Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ala235Val glpK_p.Ala235Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3532 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ala245Thr glpK_p.Ala245Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3576 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2870 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ala265fs glpK_p.Ala265fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ala277Gly glpK_p.Ala277Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3594 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2882 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ala277Val glpK_p.Ala277Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3728 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ala313Thr glpK_p.Ala313Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 3637 5574 False False 0 0 1.43785249906968 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ala318Thr glpK_p.Ala318Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3729 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2982 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ala318Val glpK_p.Ala318Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01632529799099 0.509386028876591 1135.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48598624162872 0.526186417038858 925 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ala324Thr glpK_p.Ala324Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3559 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2858 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ala364Val glpK_p.Ala364Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 2 8 20844 27460 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.99970875200233 0.999426206431739 0.999874251669172 0.2 0.0252107263268333 0.556095462307641 0 0 0.602364635616474 0 0 0.369416647552819 0 0 1.99594905387867 0.139112987544265 299 5574 False False 0.329351372097486 0.0340635477373695 1.6506834450398 0 0 0.000176959943030976 0.99970875200233 0.999426206431739 0.999874251669172 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 4 13373 21309 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999812321118566 0.999519537882235 0.999948861529775 0.2 0.00505076337946806 0.716417936118089 0 0 0.975 0 0 0.602364635616474 0 0 62.0875434180097 1 1642.5 4479 False False 0 0 0 0 0 0 0 0.398358633066626 0.00809276091420046 4.02622197901862 0 0 0.000275807277411719 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ala370fs glpK_p.Ala370fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3600 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ala370Val glpK_p.Ala370Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3701 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2961 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ala377Val glpK_p.Ala377Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3624 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2907 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ala37Val glpK_p.Ala37Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3615 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2900 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ala380Val glpK_p.Ala380Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3625 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2908 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ala391Val glpK_p.Ala391Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ala394Thr glpK_p.Ala394Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ala396fs glpK_p.Ala396fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2883 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ala396Gly glpK_p.Ala396Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3585 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2875 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ala396Ser glpK_p.Ala396Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ala396Val glpK_p.Ala396Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ala400Val glpK_p.Ala400Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ala40Ser glpK_p.Ala40Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 51.3533466119536 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 62.1009148060541 1 1642.5 4479 False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 0 0 0.000275827900298067 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ala414Val glpK_p.Ala414Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ala440Gly glpK_p.Ala440Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3688 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ala453Thr glpK_p.Ala453Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ala453Val glpK_p.Ala453Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 2 20844 27466 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999927188000582 0.999737003036386 0.999991182007438 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3719 5574 False False 1.3176933410094 0.0955278435529395 18.1762534351792 0 0 0.000176959943030976 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2977 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ala457Ser glpK_p.Ala457Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3611 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2898 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ala457Val glpK_p.Ala457Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3665 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2936 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ala463Glu glpK_p.Ala463Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ala463Val glpK_p.Ala463Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3730 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2983 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ala464Gly glpK_p.Ala464Gly 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 4 20845 27464 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999854376001165 0.999627187086024 0.999960320981843 0.2 0.00505076337946806 0.716417936118089 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3712 5574 False False 0.329383545214679 0.00669260119676484 3.32889360843958 0 0 0.000176951454458875 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 4 13373 21309 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999812321118566 0.999519537882235 0.999948861529775 0.2 0.00505076337946806 0.716417936118089 NA NA NA 0 0 0.602364635616474 NA NA NA NA 2971 4479 False False 0 0 0 0 0 0 0 0.398358633066626 0.00809276091420046 4.02622197901862 0 0 0.000275807277411719 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ala467Ser glpK_p.Ala467Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ala467Val glpK_p.Ala467Val 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3702 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2962 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ala472Glu glpK_p.Ala472Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ala472Pro glpK_p.Ala472Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3680 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2944 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ala479Thr glpK_p.Ala479Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ala498Gly glpK_p.Ala498Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ala498Val glpK_p.Ala498Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ala501Asp glpK_p.Ala501Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3689 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2951 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ala53Val glpK_p.Ala53Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ala77Val glpK_p.Ala77Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3745 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2993 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ala86Val glpK_p.Ala86Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ala87Val glpK_p.Ala87Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3560 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2859 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Arg102Trp glpK_p.Arg102Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Arg118His glpK_p.Arg118His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3581 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2874 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Arg121Cys glpK_p.Arg121Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3545 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Arg131Ser glpK_p.Arg131Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 7.01573328293188 0.509380354735251 864 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.48495357236853 0.526173219289417 690 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 1 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Arg136Ser glpK_p.Arg136Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3601 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2888 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Arg137Cys glpK_p.Arg137Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3703 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2963 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Arg202Gln glpK_p.Arg202Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Arg225Trp glpK_p.Arg225Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2893 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Arg28Gly glpK_p.Arg28Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3552 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Arg297Gln glpK_p.Arg297Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Arg334Cys glpK_p.Arg334Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3577 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2871 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Arg334Gly glpK_p.Arg334Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3626 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2909 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Arg351His glpK_p.Arg351His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3650 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2924 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Arg395Ser glpK_p.Arg395Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Arg406Cys glpK_p.Arg406Cys 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3553 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2855 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Arg41Cys glpK_p.Arg41Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Arg478Gln glpK_p.Arg478Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 51.349017027227 1 2027.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Arg509Trp glpK_p.Arg509Trp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3666 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Arg52Trp glpK_p.Arg52Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Arg66Ser glpK_p.Arg66Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3539 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2846 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Arg94Leu glpK_p.Arg94Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3638 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Asn110fs glpK_p.Asn110fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Asn183Ser glpK_p.Asn183Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3586 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2876 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Asn199fs glpK_p.Asn199fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3540 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2847 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Asn279fs glpK_p.Asn279fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3627 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2910 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Asn279Lys glpK_p.Asn279Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3736 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2987 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Asn285fs glpK_p.Asn285fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Asn299Asp glpK_p.Asn299Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 25 7 20821 27461 0.00119927084332725 0.000776250516059497 0.00176985477840228 0.999745158002038 0.999474999027776 0.999897534357495 0.78125 0.600271736287892 0.90722846771528 0 0 0.521823750104981 0 0 0.409616397225003 0 0 1.43947685377271 0.0744347802999323 275 5574 False False 4.71038855002161 1.98009029330466 12.9008687337396 0 0 0.0001771554052158 0.999745158002038 0.999474999027776 0.999897534357495 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 9 3 13365 21310 0.000672947510094212 0.000307759154923187 0.00127707788784856 0.999859240838924 0.999588697652472 0.999970971136275 0.75 0.42814153812181 0.945139355472007 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.49066749497788 0.526246257782959 979 4479 False False 0 0 0 0 0 0 0 4.78338945005611 1.19341740935517 27.4726907243458 0 0 0.000275972346901473 0.999859240838924 0.999588697652472 0.999970971136275 5 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Asn312Lys glpK_p.Asn312Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3737 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2988 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Asn356Ser glpK_p.Asn356Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3720 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2978 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Asn388Lys glpK_p.Asn388Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 4 1 20842 27467 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999963594000291 0.999797175631493 0.999999078280314 0.8 0.28358206388191 0.994949236620532 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.31786776700892 0.0167951681556147 103.371981981508 1 1253.5 5574 False False 5.27147106803569 0.521589398427432 259.279173455301 4.79777383294151e-05 1.21469042880762e-06 0.000267285534484979 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.59377804367334 0.0203020758039404 124.993150249237 1 1642.5 4479 False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 7.47775368279368e-05 1.89320152683959e-06 0.000416562561410248 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Asn390Ser glpK_p.Asn390Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3595 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2884 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Asn59Asp glpK_p.Asn59Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3533 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2841 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Asn59Lys glpK_p.Asn59Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3554 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2856 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Asn59Ser glpK_p.Asn59Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3596 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Asn76Lys glpK_p.Asn76Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Asn79fs glpK_p.Asn79fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3561 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2860 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Asn92Ser glpK_p.Asn92Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3562 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2861 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Asp120Ala glpK_p.Asp120Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2850 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Asp120Asn glpK_p.Asp120Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Asp129His glpK_p.Asp129His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3569 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2865 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Asp160Asn glpK_p.Asp160Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 4 20843 27464 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999854376001165 0.999627187086024 0.999960320981843 0.428571428571428 0.0989882784425078 0.815948432359917 0 0 0.975 0 0 0.602364635616474 0 0 51.3502039740317 1 2027.5 5574 False False 0.988245454109293 0.144734627190883 5.84310835075667 0 0 0.00017696843241753 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 3 3 13371 21310 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999859240838924 0.999588697652472 0.999970971136275 0.5 0.118117248757025 0.881882751242974 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2885 4479 False False 0 0 0 0 0 0 0 1.59374766285244 0.213424225946693 11.9045637110481 0 0 0.000275848526268708 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Asp170Glu glpK_p.Asp170Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3690 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2952 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Asp170Gly glpK_p.Asp170Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Asp177Asn glpK_p.Asp177Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01632529799099 0.509386028876591 1135.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Asp177Glu glpK_p.Asp177Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3726 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2981 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Asp177Gly glpK_p.Asp177Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3546 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2851 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Asp214Gly glpK_p.Asp214Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Asp214Val glpK_p.Asp214Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3541 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Asp215Gly glpK_p.Asp215Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3738 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2989 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Asp3Asn glpK_p.Asp3Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3704 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2964 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Asp407Asn glpK_p.Asp407Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3739 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2990 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Asp407Glu glpK_p.Asp407Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3578 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Asp446Tyr glpK_p.Asp446Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.31774131644597 0.016793557463775 103.362071688999 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.59365886487699 0.0203005577541163 124.983813232444 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Asp484Asn glpK_p.Asp484Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3713 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Asp492Gly glpK_p.Asp492Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2862 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Asp493fs glpK_p.Asp493fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3746 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2994 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Asp493Gly glpK_p.Asp493Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Asp494del glpK_p.Asp494del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Asp84Ala glpK_p.Asp84Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Asp84Glu glpK_p.Asp84Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 30 4 26 9 28 20837 27440 0.000431737503597812 0.000197436276106449 0.000819413341228355 0.998980632008154 0.998527063823414 0.999322533833553 0.243243243243243 0.117725174307107 0.411991692423913 0.133333333333333 0.0375534963383633 0.307218350276126 0.125 0.0351306531033114 0.289948420190755 0.202598188872604 0.0514042515943901 0.584122428603883 0.000686298607632539 73 5574 False False 0.423285501751691 0.175679729837628 0.922954616161584 0.000191929369991843 5.22966902810668e-05 0.000491341833708728 0.998980632008154 0.998527063823414 0.999322533833553 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 14 2 12 5 13 13369 21300 0.000373859727830118 0.000121402023062639 0.000872246401868143 0.99939004363534 0.998957181904114 0.999675185224884 0.277777777777777 0.0969492125255593 0.534801965583056 0.142857142857142 0.0177945154831915 0.428129160909698 0.133333333333333 0.0165759134400836 0.404602696603372 0.265539681352382 0.0288617994442876 1.19308698748076 0.0959458039737988 192 4479 False False 0 0 0 0 0 0 0 0.612783880043959 0.171038062026926 1.832174095132 0.000149577443721486 1.81150357058828e-05 0.000540219601407813 0.99939004363534 0.998957181904114 0.999675185224884 7 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Asp84Tyr glpK_p.Asp84Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3563 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Cys271Arg glpK_p.Cys271Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3667 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2937 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Cys271Gly glpK_p.Cys271Gly 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3656 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2929 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Cys271Tyr glpK_p.Cys271Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3681 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2945 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Cys29Tyr glpK_p.Cys29Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 34 0 34 100 77 20746 27391 0.00479708337330902 0.00390475204028651 0.00583150968841852 0.997196738022426 0.9964976308951 0.997787095498383 0.564971751412429 0.488543421995697 0.639187034205071 0 0 0.102817924259012 0 0 0.046778068160404 0 0 0.15135464554468 5.1381333250667e-09 21 5574 True False 1.71467884279992 1.2603946820314 2.34039239357168 0 0 0.000177795792479156 0.997196738022426 0.9964976308951 0.997787095498383 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 30 0 30 84 71 13290 21242 0.00628084342754598 0.0050128492064353 0.00777029190976763 0.996668699854548 0.995799848386827 0.99739733798716 0.541935483870967 0.460122721413507 0.622114253050174 0 0 0.115703308222027 0 0 0.0506294079544037 0 0 0.209201424909864 5.3976033517429e-07 19 4479 True False 0 0 0 0 0 0 0 1.89099926875019 1.36111797827378 2.63350047084974 0 0 0.000277529536789337 0.996668699854548 0.995799848386827 0.99739733798716 1 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Cys307Arg glpK_p.Cys307Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Cys307Phe glpK_p.Cys307Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Cys402Tyr glpK_p.Cys402Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Gln115Arg glpK_p.Gln115Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Gln153Pro glpK_p.Gln153Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3564 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2863 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Gln153* glpK_p.Gln153* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Gln262Arg glpK_p.Gln262Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3714 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2972 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Gln269* glpK_p.Gln269* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3582 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Gln331His glpK_p.Gln331His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Gln336His glpK_p.Gln336His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3547 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2852 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Gln345Lys glpK_p.Gln345Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Gln345Pro glpK_p.Gln345Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3570 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2866 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Gln352His glpK_p.Gln352His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Gln404Glu glpK_p.Gln404Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Gln404His glpK_p.Gln404His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3616 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2901 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Gln421His glpK_p.Gln421His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3628 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2911 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Gln439Lys glpK_p.Gln439Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3629 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2912 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Gln508* glpK_p.Gln508* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 51.349017027227 1 2027.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Gln9Glu glpK_p.Gln9Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 2 3 20844 27465 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999890782000873 0.99968085216583 0.999977476056514 0.4 0.0527449505263169 0.853367200365326 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18895916093986 0.264083883232833 556.5 5574 False False 0.878430243715217 0.0733354884838472 7.66963698207431 0 0 0.000176959943030976 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Glu157Gly glpK_p.Glu157Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 51.3533466119536 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 62.1009148060541 1 1642.5 4479 False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 0 0 0.000275827900298067 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Glu167Gly glpK_p.Glu167Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3571 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Glu209Lys glpK_p.Glu209Lys 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 28 45 20818 27423 0.00134318334452652 0.000892715366584833 0.00194069331308385 0.998361730013106 0.997808473060249 0.998804791378681 0.383561643835616 0.27208638354562 0.504793771269344 NA NA NA 0 0 0.078705100406843 NA NA NA NA 3705 5574 False False 0.819636852723604 0.49219270495865 1.34332561861849 0 0 0.000177180932121844 0.998361730013106 0.997808473060249 0.998804791378681 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 28 44 13346 21269 0.00209361447584866 0.00139162853566266 0.00302444516059537 0.997935532304227 0.997229528416783 0.99849956619829 0.388888888888888 0.276154685847455 0.51106306377231 NA NA NA 0 0 0.0804199397635758 NA NA NA NA 2965 4479 False False 0 0 0 0 0 0 0 1.0141479231094 0.607677305049188 1.66677100318416 0 0 0.000276365179957634 0.997935532304227 0.997229528416783 0.99849956619829 5 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Glu216Gln glpK_p.Glu216Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3668 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Glu216Gly glpK_p.Glu216Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3587 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2877 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Glu230Ala glpK_p.Glu230Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 11 0 11 2 11 20844 27457 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999599534003203 0.9992835689522 0.999800072407065 0.153846153846153 0.0192066719825284 0.454471055676557 0 0 0.284914152918154 0 0 0.284914152918154 0 0 0.524919694855171 0.00349760191700632 102.5 5574 False False 0.239502102196402 0.02578903914769 1.09755702800922 0 0 0.000176959943030976 0.999599534003203 0.9992835689522 0.999800072407065 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 1 9 13373 21304 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999577722516773 0.999198537836033 0.999806890245066 0.1 0.00252857854446178 0.445016117028195 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.807262280665647 0.015362431781481 102 4479 False False 0 0 0 0 0 0 0 0.177006738286929 0.00404223590282617 1.27765801502961 0 0 0.000275807277411719 0.999577722516773 0.999198537836033 0.999806890245066 2 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Glu230Lys glpK_p.Glu230Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3588 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2878 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Glu238Ala glpK_p.Glu238Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Glu238Gly glpK_p.Glu238Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Glu276Gly glpK_p.Glu276Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 5 0 20841 27468 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 1 0.999865711673152 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 3606 5574 False False Inf 1.20760984683633 Inf 0 0 0.000176985413634466 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2894 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Glu276Lys glpK_p.Glu276Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Glu320Lys glpK_p.Glu320Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Glu347Ala glpK_p.Glu347Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3669 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2938 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Glu38Gly glpK_p.Glu38Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3565 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Glu413Lys glpK_p.Glu413Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3534 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Glu495Gly glpK_p.Glu495Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Glu57Asp glpK_p.Glu57Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Glu65Gly glpK_p.Glu65Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Glu8Gly glpK_p.Glu8Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3706 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2966 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Gly105Glu glpK_p.Gly105Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3740 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Gly150Asp glpK_p.Gly150Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3548 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Gly161Arg glpK_p.Gly161Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3607 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2895 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Gly161Glu glpK_p.Gly161Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3741 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Gly169Arg glpK_p.Gly169Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3747 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2995 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Gly187Glu glpK_p.Gly187Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3583 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Gly191dup glpK_p.Gly191dup 2 inframe_insertion (see "Genomic_coordinates" sheet) NA 0 0 0 3 22 20843 27446 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999199068006407 0.998787628960307 0.999497994263003 0.12 0.0254653966477332 0.312190307286235 NA NA NA 0 0 0.154372512815574 NA NA NA NA 3742 5574 False True 0.179563228116699 0.0343787869927527 0.597815592903154 0 0 0.00017696843241753 0.999199068006407 0.998787628960307 0.999497994263003 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 3 15 13371 21298 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999296204194623 0.998839461100611 0.999606039023746 0.166666666666666 0.0357850831215746 0.414177491394774 NA NA NA 0 0 0.218019360910534 NA NA NA NA 2991 4479 False True 0 1 1 0 0 0 0 0.318570039638022 0.0591108516761482 1.12648849438386 0 0 0.000275848526268708 0.999296204194623 0.998839461100611 0.999606039023746 22 5) Not assoc w R New NotAwR yes 5 +Isoniazid glpK p.Gly191fs glpK_p.Gly191fs 2 frameshift (see "Genomic_coordinates" sheet) 1 11 0 11 6 25 20840 27443 0.000287825002398541 0.000105633792978048 0.000626367784710498 0.999089850007281 0.998656730244862 0.999410915028568 0.193548387096774 0.0745198973111289 0.374732166106584 0 0 0.284914152918154 0 0 0.137185171530712 0 0 0.524752859146597 0.00349710332181229 95 5574 False False 0.316042226487524 0.106031618505061 0.789406298622445 0 0 0.000176993905465082 0.999089850007281 0.998656730244862 0.999410915028568 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 4 14 13370 21299 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 0.999343123914981 0.998898118907794 0.999640834680135 0.222222222222222 0.0640920477176664 0.47637276573648 0 0 0.369416647552819 0 0 0.231635761650116 0 0 0.933456326691238 0.0270149119936143 121 4479 False False 0 0 0 0 0 0 0 0.455155465327492 0.109067666869582 1.44971086208314 0 0 0.000275869155324334 0.999343123914981 0.998898118907794 0.999640834680135 4 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Gly23Asp glpK_p.Gly23Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3639 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2917 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Gly23Val glpK_p.Gly23Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Gly247Arg glpK_p.Gly247Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Gly247Trp glpK_p.Gly247Trp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3589 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2879 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Gly250Asp glpK_p.Gly250Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Gly260Ala glpK_p.Gly260Ala 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 42 20845 27426 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.998470948012232 0.997933721766724 0.99889777846355 0.0232558139534883 0.000588612931593182 0.122890482701339 NA NA NA 0 0 0.0840838549403552 NA NA NA NA 3535 5574 False False 0.0313264571839769 0.000779406383781228 0.184368908125602 0 0 0.000176951454458875 0.998470948012232 0.997933721766724 0.99889777846355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 42 13373 21271 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.998029371744944 0.997337206394325 0.998579386728924 0.0232558139534883 0.000588612931593182 0.122890482701339 NA NA NA 0 0 0.0840838549403552 NA NA NA NA 2842 4479 False False 0 0 0 0 0 0 0 0.0378712615682629 0.000941149387356766 0.222910111937328 0 0 0.000275807277411719 0.998029371744944 0.997337206394325 0.998579386728924 3 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Gly292Ala glpK_p.Gly292Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3651 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Gly292Ser glpK_p.Gly292Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3608 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2896 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Gly301Cys glpK_p.Gly301Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3572 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2867 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Gly301Val glpK_p.Gly301Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3754 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3001 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Gly311Glu glpK_p.Gly311Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Gly338Asp glpK_p.Gly338Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3640 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Gly342dup glpK_p.Gly342dup 2 inframe_insertion (see "Genomic_coordinates" sheet) 0 0 0 0 2 2 20844 27466 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999927188000582 0.999737003036386 0.999991182007438 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3695 5574 False False 1.3176933410094 0.0955278435529395 18.1762534351792 0 0 0.000176959943030976 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2957 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Gly357Ser glpK_p.Gly357Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3748 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Gly358del glpK_p.Gly358del 2 inframe_deletion (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3590 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Gly36Ser glpK_p.Gly36Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3749 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2996 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Gly379Ser glpK_p.Gly379Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3670 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Gly417fs glpK_p.Gly417fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Gly417Ser glpK_p.Gly417Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3652 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2925 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Gly427Ser glpK_p.Gly427Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3536 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2843 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Gly465Ala glpK_p.Gly465Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Gly469Arg glpK_p.Gly469Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3657 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2930 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Gly499fs glpK_p.Gly499fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Gly499Val glpK_p.Gly499Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3755 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Gly54Ser glpK_p.Gly54Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3671 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Gly89Ala glpK_p.Gly89Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Gly89Glu glpK_p.Gly89Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3630 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2913 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.His103Arg glpK_p.His103Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.His103Asn glpK_p.His103Asn 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3612 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.His103Tyr glpK_p.His103Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.His193fs glpK_p.His193fs 2 frameshift (see "Genomic_coordinates" sheet) 1 7 0 7 2 8 20844 27460 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.99970875200233 0.999426206431739 0.999874251669172 0.2 0.0252107263268333 0.556095462307641 0 0 0.409616397225003 0 0 0.369416647552819 0 0 0.914175646334046 0.0219777167393779 162 5574 False False 0.329351372097486 0.0340635477373695 1.6506834450398 0 0 0.000176959943030976 0.99970875200233 0.999426206431739 0.999874251669172 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 5 13374 21308 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 2.41409066157565 0.305475026346142 461 4479 False False 0 0 0 0 0 0 0 0 0 1.73894646374006 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 1 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.His35Tyr glpK_p.His35Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.His392Gln glpK_p.His392Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3756 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.His42Asp glpK_p.His42Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3750 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2997 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.His42Tyr glpK_p.His42Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3617 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2902 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.His58Arg glpK_p.His58Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3537 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2844 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.His58Asn glpK_p.His58Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3696 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ile112Thr glpK_p.Ile112Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3609 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ile112Val glpK_p.Ile112Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3707 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ile122Val glpK_p.Ile122Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ile223Thr glpK_p.Ile223Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3566 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ile255Leu glpK_p.Ile255Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3672 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2939 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ile323Val glpK_p.Ile323Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3673 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ile401Met glpK_p.Ile401Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3641 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ile429Thr glpK_p.Ile429Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3731 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2984 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ile49Thr glpK_p.Ile49Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ile5Leu glpK_p.Ile5Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3691 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2953 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ile5Met glpK_p.Ile5Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3708 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2967 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ile5Thr glpK_p.Ile5Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3597 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ile85Thr glpK_p.Ile85Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3682 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2946 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ile90fs glpK_p.Ile90fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3555 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ile90Thr glpK_p.Ile90Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Leu126Met glpK_p.Leu126Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Leu141Met glpK_p.Leu141Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Leu152Arg glpK_p.Leu152Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3567 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2864 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Leu152Val glpK_p.Leu152Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3721 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Leu156Val glpK_p.Leu156Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3683 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2947 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Leu172Phe glpK_p.Leu172Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3602 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2889 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Leu205Val glpK_p.Leu205Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Leu218Val glpK_p.Leu218Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3598 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2886 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Leu228Ala glpK_p.Leu228Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3573 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2868 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Leu228Val glpK_p.Leu228Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 87 423 20759 27045 0.00417346253477885 0.00334408237977382 0.00514544058942265 0.984600262123198 0.983073491132757 0.986023231620728 0.170588235294117 0.13895069750827 0.20609994384305 NA NA NA 0 0 0.00868283972223171 NA NA NA NA 3697 5574 False True 0.267953504914043 0.210086336409213 0.338487184392369 0 0 0.0001776844605294 0.984600262123198 0.983073491132757 0.986023231620728 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 62 291 13312 21022 0.00463586062509346 0.00355607973710565 0.00593907742123671 0.986346361375686 0.984696820424186 0.987861202946972 0.175637393767705 0.137392623516096 0.219424633174765 NA NA NA 0 0 0.0125965525269814 NA NA NA NA 2958 4479 False True 0 1 1 0 0 0 0 0.336456887721385 0.251311564715506 0.444351369696064 0 0 0.000277070942747713 0.986346361375686 0.984696820424186 0.987861202946972 8 5) Not assoc w R New NotAwR yes 5 +Isoniazid glpK p.Leu259Phe glpK_p.Leu259Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Leu272Val glpK_p.Leu272Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Leu287Pro glpK_p.Leu287Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3724 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2980 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Leu319Arg glpK_p.Leu319Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3658 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Leu333Ile glpK_p.Leu333Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 2 9 20844 27459 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999672346002621 0.99937810218515 0.999850165132458 0.181818181818181 0.0228311982999596 0.517755852360172 0 0 0.369416647552819 0 0 0.336267116879942 0 0 0.771854506059491 0.0121125680946169 129.5 5574 False False 0.292746113989637 0.0307804028975754 1.41460768720699 0 0 0.000176959943030976 0.999672346002621 0.99937810218515 0.999850165132458 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 2 7 13372 21306 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.99967156195749 0.999323409938814 0.999867941002665 0.222222222222222 0.0281449734778982 0.600093573716312 0 0 0.4592581264399 0 0 0.409616397225003 0 0 1.35349447126629 0.0884843124151618 180 4479 False False 0 0 0 0 0 0 0 0.455236955685654 0.0461387128464925 2.39147917078199 0 0 0.000275827900298067 0.99967156195749 0.999323409938814 0.999867941002665 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Leu337fs glpK_p.Leu337fs 2 frameshift (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Leu349Pro glpK_p.Leu349Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Leu393Val glpK_p.Leu393Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3715 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2973 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Leu398Met glpK_p.Leu398Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3621 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2904 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Leu398Pro glpK_p.Leu398Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3610 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2897 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Leu420Met glpK_p.Leu420Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Leu423Phe glpK_p.Leu423Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3603 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2890 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Leu44Arg glpK_p.Leu44Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3653 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2926 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Leu466Phe glpK_p.Leu466Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 11 3 20835 27465 0.000527679171063993 0.000263444034397523 0.000943967185544106 0.999890782000873 0.99968085216583 0.999977476056514 0.785714285714285 0.492024322951528 0.953420712110132 0 0 0.975 0 0 0.707598226178713 0 0 51.3717739248466 1 2027.5 5574 False False 4.8334533237341 1.27655660334634 26.9843248104776 0 0 0.000177036376844338 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 8 3 13366 21310 0.000598175564528189 0.000258283997825234 0.00117830226263269 0.999859240838924 0.999588697652472 0.999970971136275 0.727272727272727 0.390257440427578 0.939782265827093 0 0 0.975 0 0 0.707598226178713 0 0 62.12294038734 1 1642.5 4479 False False 0 0 0 0 0 0 0 4.25158362013068 1.02017461695649 24.8845961015246 0 0 0.000275951702410535 0.999859240838924 0.999588697652472 0.999970971136275 1 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Lys505Asn glpK_p.Lys505Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Lys83Glu glpK_p.Lys83Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 3579 5574 False False 0 0 1.43785249906968 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 2872 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Met1? glpK_p.Met1? 2 start_lost (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3642 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2918 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Met206Ile glpK_p.Met206Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3716 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2974 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Met227Ile glpK_p.Met227Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 1.99604811372315 0.139118032244638 322.5 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.41420404242617 0.305473156458586 444 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Met266fs glpK_p.Met266fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3538 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2845 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Met30Val glpK_p.Met30Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3757 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3002 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Met359Ile glpK_p.Met359Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3556 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2857 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Met412Ile glpK_p.Met412Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 1 6 20845 27462 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999781564001747 0.999524617886493 0.999919833755107 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.521823750104981 0 0 0.4592581264399 0 0 1.43786917636023 0.0743390630358733 263 5574 False False 0.219573039098105 0.00477770915407814 1.81014820057657 0 0 0.000176951454458875 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.85633740727807 0.289259828934126 294 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Met412Thr glpK_p.Met412Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3631 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Met412Val glpK_p.Met412Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3613 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Phe147Leu glpK_p.Phe147Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3674 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2940 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Phe16Leu glpK_p.Phe16Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Phe16Ser glpK_p.Phe16Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3751 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2998 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Phe173Tyr glpK_p.Phe173Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Phe32Cys glpK_p.Phe32Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3632 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2914 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Phe365Leu glpK_p.Phe365Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 7.01573328293188 0.509380354735251 864 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Phe369Leu glpK_p.Phe369Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Phe470Leu glpK_p.Phe470Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Pro142Ser glpK_p.Pro142Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3580 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2873 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Pro143Ser glpK_p.Pro143Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3659 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2931 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Pro143Thr glpK_p.Pro143Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Pro176Leu glpK_p.Pro176Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Pro176Ser glpK_p.Pro176Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Pro236Ala glpK_p.Pro236Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3684 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2948 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Pro239Arg glpK_p.Pro239Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Pro239Ser glpK_p.Pro239Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3618 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2903 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Pro248Ser glpK_p.Pro248Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3604 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2891 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Pro254fs glpK_p.Pro254fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3542 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2848 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Pro254Gln glpK_p.Pro254Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3675 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2941 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Pro254Leu glpK_p.Pro254Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Pro254Ser glpK_p.Pro254Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3722 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Pro274Leu glpK_p.Pro274Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3660 5574 False False 0.439194051331254 0.00837049629364692 5.4704842261679 0 0 0.000176951454458875 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2932 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Pro315Leu glpK_p.Pro315Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 3 20843 27465 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999890782000873 0.99968085216583 0.999977476056514 0.5 0.118117248757025 0.881882751242974 0 0 0.975 0 0 0.707598226178713 0 0 51.3520721335729 1 2027.5 5574 False False 1.31770858321738 0.176469385678871 9.83712695959095 0 0 0.00017696843241753 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 2 13371 21311 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999906160559283 0.999661061221376 0.999988635406343 0.6 0.146632799634673 0.947255049473683 0 0 0.975 0 0 0.841886116991581 0 0 62.1026435994552 1 1642.5 4479 False False 0 0 0 0 0 0 0 2.39073367736145 0.273835790357664 28.6284716983702 0 0 0.000275848526268708 0.999906160559283 0.999661061221376 0.999988635406343 1 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Pro354Arg glpK_p.Pro354Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3591 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Pro354Ser glpK_p.Pro354Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Pro354Thr glpK_p.Pro354Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Pro363Arg glpK_p.Pro363Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3727 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Pro363Ser glpK_p.Pro363Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3717 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2975 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Pro371Ser glpK_p.Pro371Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3661 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Pro474Ala glpK_p.Pro474Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Pro474Leu glpK_p.Pro474Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 3 2 20843 27466 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999927188000582 0.999737003036386 0.999991182007438 0.6 0.146632799634673 0.947255049473683 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01699856622015 0.509392482788101 1176.5 5574 False False 1.97663484143357 0.226402568392661 23.6672561646805 0 0 0.00017696843241753 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 3 2 13371 21311 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999906160559283 0.999661061221376 0.999988635406343 0.6 0.146632799634673 0.947255049473683 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.4872555868813 0.526202640597156 962.5 4479 False False 0 0 0 0 0 0 0 2.39073367736145 0.273835790357664 28.6284716983702 0 0 0.000275848526268708 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Pro489Arg glpK_p.Pro489Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3619 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Pro51Ala glpK_p.Pro51Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3633 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Pro51Leu glpK_p.Pro51Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Pro82Leu glpK_p.Pro82Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ser124Leu glpK_p.Ser124Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ser124Pro glpK_p.Ser124Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 2 20843 27466 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999927188000582 0.999737003036386 0.999991182007438 0.6 0.146632799634673 0.947255049473683 0 0 0.975 0 0 0.841886116991581 0 0 51.3539402930048 1 2027.5 5574 False False 1.97663484143357 0.226402568392661 23.6672561646805 0 0 0.00017696843241753 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2949 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ser13Pro glpK_p.Ser13Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ser237Ala glpK_p.Ser237Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3662 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2933 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ser26Arg glpK_p.Ser26Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3718 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2976 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ser2fs glpK_p.Ser2fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ser2Phe glpK_p.Ser2Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3643 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2919 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ser2Thr glpK_p.Ser2Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ser366Cys glpK_p.Ser366Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ser375Phe glpK_p.Ser375Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3614 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2899 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ser416Ala glpK_p.Ser416Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3654 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2927 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ser416Tyr glpK_p.Ser416Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 4 2 20842 27466 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999927188000582 0.999737003036386 0.999991182007438 0.666666666666666 0.222778095503512 0.956728131707258 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01733524879011 0.509395710775307 1192 5574 False False 2.63563957393724 0.377684835565828 29.1411399702847 0 0 0.000176976922618654 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ser517Cys glpK_p.Ser517Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3698 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2959 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Ser73Trp glpK_p.Ser73Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Thr117Ile glpK_p.Thr117Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3685 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Thr145Ser glpK_p.Thr145Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3584 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Thr185Ile glpK_p.Thr185Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3676 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Thr195fs glpK_p.Thr195fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Thr203Ala glpK_p.Thr203Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3758 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3003 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Thr243Lys glpK_p.Thr243Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3622 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2905 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Thr24Ala glpK_p.Thr24Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3752 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2999 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Thr256Ile glpK_p.Thr256Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3592 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2880 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Thr280Ala glpK_p.Thr280Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3677 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2942 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Thr280Asn glpK_p.Thr280Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3709 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2968 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Thr283fs glpK_p.Thr283fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Thr291Asn glpK_p.Thr291Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3759 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3004 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Thr294Met glpK_p.Thr294Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Thr326Ala glpK_p.Thr326Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3678 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Thr326fs glpK_p.Thr326fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3634 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Thr326Ser glpK_p.Thr326Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3732 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Thr397Ala glpK_p.Thr397Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 4 1 20842 27467 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999963594000291 0.999797175631493 0.999999078280314 0.8 0.28358206388191 0.994949236620532 0 0 0.975 0 0 0.975 0 0 51.3582705287504 1 2027.5 5574 False False 5.27147106803569 0.521589398427432 259.279173455301 0 0 0.000176976922618654 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Thr397Met glpK_p.Thr397Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Thr430Ala glpK_p.Thr430Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 26 0 26 6 39 20840 27429 0.000287825002398541 0.000105633792978048 0.000626367784710498 0.998580166011358 0.998059546022616 0.998990170448098 0.133333333333333 0.0505423759133262 0.267924954093447 0 0 0.132274604497754 0 0 0.0902511009603342 0 0 0.200692088969274 6.09936802160792e-07 29 5574 True False 0.202487819282445 0.0700447315380051 0.481816362958706 0 0 0.000176993905465082 0.998580166011358 0.998059546022616 0.998990170448098 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 16 0 16 3 28 13371 21285 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.998686247829963 0.99810181776224 0.999126849229516 0.0967741935483871 0.0204198626877921 0.257539064627735 0 0 0.205907214207822 0 0 0.123436118500263 0 0 0.412841854720472 0.000489899441449332 47 4479 True False 0 0 0 0 0 0 0 0.170558351229206 0.0331657004521639 0.552344201861615 0 0 0.000275848526268708 0.998686247829963 0.99810181776224 0.999126849229516 7 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Thr430Ser glpK_p.Thr430Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3593 5574 False False Inf 0.869878292971449 Inf 0 0 0.000176976922618654 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 13370 21313 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 1 0.999826933785262 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2881 4479 False False 0 0 0 0 0 0 0 Inf 1.05210128917758 Inf 0 0 0.000275869155324334 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Thr455fs glpK_p.Thr455fs 2 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3623 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Thr488Ile glpK_p.Thr488Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3663 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2934 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Thr490Met glpK_p.Thr490Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3549 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Thr490Ser glpK_p.Thr490Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 3.18842099130276 0.264066860104113 431 5574 False False 0 0 1.43785249906968 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 5 13374 21308 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 3.85615642482772 0.289252196403212 283.5 4479 False False 0 0 0 0 0 0 0 0 0 1.73894646374006 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Thr510Ile glpK_p.Thr510Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3605 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2892 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Thr78Ala glpK_p.Thr78Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3725 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Thr91Ala glpK_p.Thr91Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Thr97fs glpK_p.Thr97fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3550 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2853 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Thr97Lys glpK_p.Thr97Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3568 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Trp100fs glpK_p.Trp100fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3644 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2920 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Trp114Arg glpK_p.Trp114Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Trp114* glpK_p.Trp114* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Trp213Arg glpK_p.Trp213Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3743 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Trp213* glpK_p.Trp213* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Trp332Arg glpK_p.Trp332Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Trp471Cys glpK_p.Trp471Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3635 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2915 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Trp487fs glpK_p.Trp487fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3753 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3000 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Trp513Arg glpK_p.Trp513Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 1 20843 27467 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999963594000291 0.999797175631493 0.999999078280314 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 51.3558084523276 1 2027.5 5574 False False 3.95341361608213 0.31739219148065 207.323829234655 0 0 0.00017696843241753 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Trp64Leu glpK_p.Trp64Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3679 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2943 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Tyr109Cys glpK_p.Tyr109Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Tyr281* glpK_p.Tyr281* 2 stop_gained (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01632529799099 0.509386028876591 1135.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2906 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Tyr308His glpK_p.Tyr308His 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.31767810026385 0.0167927522337569 103.35711725526 1 1253.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Tyr372Cys glpK_p.Tyr372Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3744 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2992 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Tyr372fs glpK_p.Tyr372fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Tyr462fs glpK_p.Tyr462fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3557 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Tyr500Cys glpK_p.Tyr500Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3655 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2928 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Val113Ala glpK_p.Val113Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3733 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Val113Ile glpK_p.Val113Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Val159Ile glpK_p.Val159Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Val162Leu glpK_p.Val162Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Val192fs glpK_p.Val192fs 2 frameshift (see "Genomic_coordinates" sheet) 1 77 7 70 384 155 20462 27313 0.0184208001535066 0.0166388300274137 0.0203388025095695 0.994357070045143 0.993398660515462 0.99520849769484 0.712430426716141 0.672197866399074 0.75031543640919 0.0909090909090909 0.0373358946999443 0.178378556642483 0.0432098765432098 0.0175465248107336 0.0870001407782384 0.133481575603557 0.0517748165597362 0.289887356498765 1.441506160293e-10 15 5574 True False 3.3068983891462 2.73459069937154 4.01485854182038 0.000341980555962675 0.000137504620897464 0.000704482897368741 0.994357070045143 0.993398660515462 0.99520849769484 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 45 2 43 173 106 13201 21207 0.012935546582922 0.011089650875081 0.0149976321595733 0.995026509642002 0.993987842753232 0.995926370790782 0.620071684587813 0.560293336930617 0.677270202798141 0.0444444444444444 0.00542848870025094 0.151492900243339 0.0185185185185185 0.00225059950165782 0.0652965469444737 0.074719497994338 0.00875944173975275 0.286915224646472 2.24823422225327e-07 15 4479 True False 0 0 0 0 0 0 0 2.62187898858434 2.04474516150749 3.37451006178613 0.000151480724077861 1.83455449342387e-05 0.000547092201264644 0.995026509642002 0.993987842753232 0.995926370790782 44 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Val192Met glpK_p.Val192Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3574 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Val253Leu glpK_p.Val253Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.43785249906968 0.0743380732312645 251 5574 False False 0 0 1.43785249906968 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.41420404242617 0.305473156458586 444 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Val267Ile glpK_p.Val267Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3558 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Val270Phe glpK_p.Val270Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3636 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2916 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Val296Ala glpK_p.Val296Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Val296Met glpK_p.Val296Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3645 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2921 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Val325Met glpK_p.Val325Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Val330Leu glpK_p.Val330Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3686 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2950 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Val353Ala glpK_p.Val353Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3687 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Val353Phe glpK_p.Val353Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Val362Ala glpK_p.Val362Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Val382Ala glpK_p.Val382Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Val39Ala glpK_p.Val39Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Val39Leu glpK_p.Val39Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 7.01547785354097 0.509377906736075 843 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Val408Leu glpK_p.Val408Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3543 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2849 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Val418Asp glpK_p.Val418Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3734 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2985 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Val422Met glpK_p.Val422Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3723 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2979 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Val425Ala glpK_p.Val425Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3599 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2887 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Val442Met glpK_p.Val442Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Val447Glu glpK_p.Val447Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3646 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Val452Leu glpK_p.Val452Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3647 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Val460Ala glpK_p.Val460Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1033 3576 19813 23892 0.0495538712462822 0.0466468301662347 0.0525873309629787 0.869812145041502 0.86577526774208 0.873770620201756 0.224126708613582 0.212157055477577 0.236446854814984 NA NA NA 0 0 0.00103103396173479 NA NA NA NA 3710 5574 False True 0.348341387950491 0.323894249367144 0.374405521157676 0 0 0.000186167469276864 0.869812145041502 0.86577526774208 0.873770620201756 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 753 2919 12621 18394 0.0563032750112157 0.0524561588601908 0.0603448396907804 0.863041336273635 0.858352668659682 0.867630745231282 0.205065359477124 0.192108989580505 0.218492882162232 NA NA NA 0 0 0.00126294947902891 NA NA NA NA 2969 4479 False True 0 1 1 0 0 0 0 0.375961433305052 0.345498922079255 0.408797580110979 0 0 0.000292238365565751 0.863041336273635 0.858352668659682 0.867630745231282 453 5) Not assoc w R New NotAwR yes 5 +Isoniazid glpK p.Val460Met glpK_p.Val460Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3692 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2954 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Val468Ile glpK_p.Val468Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid glpK p.Val99Ala glpK_p.Val99Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA c.102C>T hadA_c.102C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid hadA c.-10T>C hadA_c.-10T>C 2 upstream_gene_variant 731920 NA 0 0 0 6 0 20840 27468 0.000287825002398541 0.000105633792978048 0.000626367784710498 1 0.999865711673152 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 4155 5574 False False Inf 1.55167078958407 Inf 0 0 0.000176993905465082 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3327 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA c.120C>T hadA_c.120C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.43785249906968 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.41420404242617 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid hadA c.132C>T hadA_c.132C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid hadA c.138C>A hadA_c.138C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid hadA c.144C>T hadA_c.144C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid hadA c.147G>A hadA_c.147G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid hadA c.150T>C hadA_c.150T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid hadA c.157T>C hadA_c.157T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid hadA c.-16_-15insA hadA_c.-16_-15insA 2 upstream_gene_variant 731914 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4171 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3341 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA c.168G>A hadA_c.168G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid hadA c.-17_-16insG hadA_c.-17_-16insG 2 upstream_gene_variant 731913 NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4167 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3337 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA c.-19_-18insT hadA_c.-19_-18insT 2 upstream_gene_variant 731911 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4204 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3370 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA c.192C>T hadA_c.192C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid hadA c.-19C>T hadA_c.-19C>T 2 upstream_gene_variant 731911 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4198 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA c.-1C>A hadA_c.-1C>A 2 upstream_gene_variant 731929 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA c.204G>A hadA_c.204G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid hadA c.207G>A hadA_c.207G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid hadA c.-20A>G hadA_c.-20A>G 2 upstream_gene_variant 731910 1 1 0 1 0 8 20846 27460 0 0 0.00017694296670111 0.99970875200233 0.999426206431739 0.999874251669172 0 0 0.369416647552819 0 0 0.975 0 0 0.369416647552819 0 0 51.3353484006059 1 2027.5 5574 False False 0 0 0.771808536885009 0 0 0.00017694296670111 0.99970875200233 0.999426206431739 0.999874251669172 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 7 13374 21306 0 0 0.000275786657608973 0.99967156195749 0.999323409938814 0.999867941002665 0 0 0.409616397225003 0 0 0.975 0 0 0.409616397225003 0 0 62.0741740239832 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 1.10552510564584 0 0 0.000275786657608973 0.99967156195749 0.999323409938814 0.999867941002665 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA c.213C>T hadA_c.213C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 5 8 20841 27460 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.99970875200233 0.999426206431739 0.999874251669172 0.384615384615384 0.13857933889016 0.684222397085936 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.823496953121251 0.211934904376016 2.85543457523295 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 4 8 13370 21305 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 0.999624642237132 0.999260530264256 0.999837933676441 0.333333333333333 0.0992460911495833 0.651124493581186 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.796746447270007 0.175554888158817 2.97493777258165 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid hadA c.216C>T hadA_c.216C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 11 106 20835 27362 0.000527679171063993 0.000263444034397523 0.000943967185544106 0.996140964030872 0.99533449487918 0.996839488644753 0.094017094017094 0.0478728905436667 0.161997027800012 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.136282833222398 0.0660193638560969 0.253968714214095 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 4 72 13370 21241 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 0.99662178013419 0.995747555724103 0.997355840664275 0.0526315789473684 0.0145245583391564 0.129309158452984 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 0 0.0882614476855314 0.0233985054411271 0.236023459466364 NA NA NA NA NA NA 28 5) Not assoc w R Now listed Silent mutation no 0 +Isoniazid hadA c.219G>A hadA_c.219G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid hadA c.-22_-21insGACTA hadA_c.-22_-21insGACTA 2 upstream_gene_variant 731908 NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4179 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3347 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA c.225G>C hadA_c.225G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 20 20843 27448 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999271880005825 0.998875700613314 0.999555190458412 0.130434782608695 0.0277515074227932 0.335889137537121 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.197533944249868 0.0375859160692748 0.666198231605716 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 19 13372 21294 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999108525313189 0.998608200368116 0.999463191365845 0.0952380952380952 0.0117493178844458 0.303774406913924 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.167624415510808 0.0189392869655141 0.695007241417293 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid hadA c.237C>T hadA_c.237C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.99604811372315 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.41420404242617 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid hadA c.240G>C hadA_c.240G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid hadA c.252C>T hadA_c.252C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 7 20845 27461 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999745158002038 0.999474999027776 0.999897534357495 0.125 0.0031597235312519 0.526509670875206 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.188198608779083 0.00417990056987037 1.46513319151887 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 3 13373 21310 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999859240838924 0.999588697652472 0.999970971136275 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.531169769934445 0.010122018243966 6.61631049307563 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid hadA c.255C>T hadA_c.255C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid hadA c.-25G>A hadA_c.-25G>A 2 upstream_gene_variant 731905 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA c.261A>C hadA_c.261A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid hadA c.273G>A hadA_c.273G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid hadA c.285A>G hadA_c.285A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid hadA c.291C>T hadA_c.291C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid hadA c.297G>A hadA_c.297G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 7 20845 27461 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999745158002038 0.999474999027776 0.999897534357495 0.125 0.0031597235312519 0.526509670875206 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.188198608779083 0.00417990056987037 1.46513319151887 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 7 13373 21306 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.99967156195749 0.999323409938814 0.999867941002665 0.125 0.0031597235312519 0.526509670875206 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.227601457093717 0.00505385949080816 1.77192833352817 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid hadA c.300C>G hadA_c.300C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 3 20844 27465 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999890782000873 0.99968085216583 0.999977476056514 0.4 0.0527449505263169 0.853367200365326 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.878430243715217 0.0733354884838472 7.66963698207431 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 3 13372 21310 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999859240838924 0.999588697652472 0.999970971136275 0.4 0.0527449505263169 0.853367200365326 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.06241898494366 0.0886985485353837 9.27715037564111 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid hadA c.306G>A hadA_c.306G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid hadA c.309G>A hadA_c.309G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.544526627735454 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid hadA c.315C>T hadA_c.315C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.869878292971449 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid hadA c.-32T>G hadA_c.-32T>G 2 upstream_gene_variant 731898 NA 0 0 0 12 0 20834 27468 0.000575650004797083 0.000297481006307132 0.00100532857413147 1 0.999865711673152 1 1 0.735351530602948 1 NA NA NA NA NA NA NA NA NA NA 4196 5574 False False Inf 3.66300284077067 Inf 0 0 0.000177044873566246 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 13370 21313 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 1 0.999826933785262 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3364 4479 False False 0 0 0 0 0 0 0 Inf 1.05210128917758 Inf 0 0 0.000275869155324334 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA c.336G>A hadA_c.336G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 36 20844 27432 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.998689384010484 0.998186012178885 0.999081897081075 0.0526315789473684 0.00643871671509191 0.17749059034764 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.0731145653425446 0.00851913229046451 0.284059995323402 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 34 13372 21279 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.998404729507812 0.997771476125476 0.998894983644582 0.0555555555555555 0.00680030065402281 0.186636706457554 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.0936064823775756 0.01089221956865 0.365241356729643 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid hadA c.339T>C hadA_c.339T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid hadA c.-33G>C hadA_c.-33G>C 2 upstream_gene_variant 731897 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 2 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA c.348C>T hadA_c.348C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 2 20843 27466 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999927188000582 0.999737003036386 0.999991182007438 0.6 0.146632799634673 0.947255049473683 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.97663484143357 0.226402568392661 23.6672561646805 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid hadA c.369C>T hadA_c.369C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid hadA c.378C>A hadA_c.378C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid hadA c.37C>A hadA_c.37C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid hadA c.396T>C hadA_c.396T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 5 19 20841 27449 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.999308286005533 0.998920012739518 0.999583493240977 0.208333333333333 0.0713186171980549 0.421512843637252 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.346596662954348 0.101143506910399 0.959912718392501 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 9 13371 21304 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999577722516773 0.999198537836033 0.999806890245066 0.25 0.0548606445279927 0.571858461878189 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.531099643507092 0.0924673877284194 2.12867851697681 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid hadA c.-39C>T hadA_c.-39C>T 2 upstream_gene_variant 731891 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA c.-3G>T hadA_c.-3G>T 2 upstream_gene_variant 731927 1 0 0 0 4 1 20842 27467 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999963594000291 0.999797175631493 0.999999078280314 0.8 0.28358206388191 0.994949236620532 NA NA NA 0 0 0.975 NA NA NA NA 4173 5574 False False 5.27147106803569 0.521589398427432 259.279173455301 0 0 0.000176976922618654 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3343 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA c.-40G>A hadA_c.-40G>A 2 upstream_gene_variant 731890 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA c.411G>A hadA_c.411G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid hadA c.438C>A hadA_c.438C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.63548263289195 0.137183409715989 155.34952410964 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid hadA c.450A>G hadA_c.450A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.99604811372315 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.41420404242617 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid hadA c.45C>T hadA_c.45C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 4 20843 27464 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999854376001165 0.999627187086024 0.999960320981843 0.428571428571428 0.0989882784425078 0.815948432359917 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.988245454109293 0.144734627190883 5.84310835075667 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.85651838973546 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid hadA c.-45G>A hadA_c.-45G>A 2 upstream_gene_variant 731885 1 2 0 2 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 7.01547785354097 0.509377906736075 843 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.48495357236853 0.526173219289417 690 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA c.468C>T hadA_c.468C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid hadA c.-46C>G hadA_c.-46C>G 2 upstream_gene_variant 731884 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4181 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3349 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA c.-46C>T hadA_c.-46C>T 2 upstream_gene_variant 731884 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4168 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3338 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA c.-4A>G hadA_c.-4A>G 2 upstream_gene_variant 731926 1 0 0 0 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4164 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3335 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA c.-50C>T hadA_c.-50C>T 2 upstream_gene_variant 731880 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4195 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3363 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA c.51C>T hadA_c.51C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 9 20843 27459 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999672346002621 0.99937810218515 0.999850165132458 0.25 0.0548606445279927 0.571858461878189 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.439140238929136 0.0764596530706342 1.75996892947283 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 5 13374 21308 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.73894646374006 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid hadA c.57G>A hadA_c.57G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid hadA c.-5C>T hadA_c.-5C>T 2 upstream_gene_variant 731925 1 0 0 0 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4188 5574 False False 0.439194051331254 0.00837049629364692 5.4704842261679 0 0 0.000176951454458875 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3356 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA c.-6A>C hadA_c.-6A>C 2 upstream_gene_variant 731924 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4156 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3328 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA c.-6A>G hadA_c.-6A>G 2 upstream_gene_variant 731924 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4202 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3369 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA c.81G>A hadA_c.81G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid hadA c.87C>G hadA_c.87C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.18865318395302 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.85651838973546 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid hadA c.87C>T hadA_c.87C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.439194051331254 0.00837049629364692 5.4704842261679 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 3 13373 21310 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999859240838924 0.999588697652472 0.999970971136275 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.531169769934445 0.010122018243966 6.61631049307563 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid hadA LoF hadA_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 7 0 7 0 7 20846 27461 0 0 0.00017694296670111 0.999745158002038 0.999474999027776 0.999897534357495 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.914121240039481 0.0219749245408003 156 5574 False False 0 0 0.914121240039481 0 0 0.00017694296670111 0.999745158002038 0.999474999027776 0.999897534357495 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Ala115Thr hadA_p.Ala115Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4200 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3366 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Ala143Val hadA_p.Ala143Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4199 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3365 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Ala146fs hadA_p.Ala146fs 2 frameshift (see "Genomic_coordinates" sheet) 1 7 0 7 0 7 20846 27461 0 0 0.00017694296670111 0.999745158002038 0.999474999027776 0.999897534357495 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.914121240039481 0.0219749245408003 156 5574 False False 0 0 0.914121240039481 0 0 0.00017694296670111 0.999745158002038 0.999474999027776 0.999897534357495 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Ala146Gly hadA_p.Ala146Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4172 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3342 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Ala157Val hadA_p.Ala157Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4158 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Ala158Ser hadA_p.Ala158Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Ala158Thr hadA_p.Ala158Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Ala29Gly hadA_p.Ala29Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4205 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Ala45Gly hadA_p.Ala45Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4182 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3350 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Ala45Val hadA_p.Ala45Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 2 2 20844 27466 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999927188000582 0.999737003036386 0.999991182007438 0.5 0.067585986488543 0.932414013511457 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.658846670504701 0.0111723913611586 12.657347321213 1 2027.5 5574 False False 1.3176933410094 0.0955278435529395 18.1762534351792 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 2 2 13372 21311 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999906160559283 0.999661061221376 0.999988635406343 0.5 0.067585986488543 0.932414013511457 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.79685163027221 0.0135109794294302 15.3087033834511 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59370326054442 0.115491055908661 21.9865025501046 7.47775368279368e-05 1.89320152683959e-06 0.000416562561410248 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Ala5Val hadA_p.Ala5Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4197 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Ala67Val hadA_p.Ala67Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4174 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3344 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Ala69Thr hadA_p.Ala69Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4177 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Ala70Gly hadA_p.Ala70Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Ala80Val hadA_p.Ala80Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4189 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3357 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Arg13Gly hadA_p.Arg13Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Arg13Trp hadA_p.Arg13Trp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 9 0 20837 27468 0.000431737503597812 0.000197436276106449 0.000819413341228355 1 0.999865711673152 1 1 0.663732883120057 1 NA NA NA NA NA NA NA NA NA NA 4160 5574 False False Inf 2.60134945111117 Inf 0 0 0.000177019385846931 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 13370 21313 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 1 0.999826933785262 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3331 4479 False False 0 0 0 0 0 0 0 Inf 1.05210128917758 Inf 0 0 0.000275869155324334 1 0.999826933785262 1 2 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Arg145His hadA_p.Arg145His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4178 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3346 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Arg22Gln hadA_p.Arg22Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4165 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3336 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Asp106Asn hadA_p.Asp106Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 19 0 19 11 21 20835 27447 0.000527679171063993 0.000263444034397523 0.000943967185544106 0.999235474006116 0.998831576963824 0.999526686034611 0.34375 0.185719091716566 0.531931036280268 0 0 0.176466911806965 0 0 0.161097615219079 0 0 0.282332075701257 2.49092072258395e-05 51 5574 True False 0.690040796736261 0.300396916785924 1.49749320063884 0 0 0.000177036376844338 0.999235474006116 0.998831576963824 0.999526686034611 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 15 0 15 8 15 13366 21298 0.000598175564528189 0.000258283997825234 0.00117830226263269 0.999296204194623 0.998839461100611 0.999606039023746 0.347826086956521 0.163763598374949 0.572656036963505 0 0 0.218019360910534 0 0 0.218019360910534 0 0 0.444364647551061 0.00085178775358701 55 4479 False False 0 0 0 0 0 0 0 0.849837897151977 0.311968965255579 2.13589648280458 0 0 0.000275951702410535 0.999296204194623 0.998839461100611 0.999606039023746 3 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Asp133Glu hadA_p.Asp133Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4190 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3358 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Asp149Gly hadA_p.Asp149Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4183 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3351 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Asp36Gly hadA_p.Asp36Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4175 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Asp43Glu hadA_p.Asp43Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Cys61Gly hadA_p.Cys61Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 261 0 20585 27468 0.0125203876043365 0.0110552641020082 0.014123695573753 1 0.999865711673152 1 1 0.985965773205603 1 NA NA NA NA NA NA NA NA NA NA 4161 5574 False False Inf 93.6325214486174 Inf 0 0 0.000179186249502346 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 166 0 13208 21313 0.0124121429639599 0.0106050223487527 0.0144357956313935 1 0.999826933785262 1 1 0.978022928071504 1 NA NA NA NA NA NA NA NA NA NA 3332 4479 False False 0 0 0 0 0 0 0 Inf 71.8162691319512 Inf 0 0 0.000279252299069062 1 0.999826933785262 1 50 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Cys61Ser hadA_p.Cys61Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 56 0 20790 27468 0.00268636668905305 0.00202987113537781 0.00348707100741373 1 0.999865711673152 1 1 0.936249903337637 1 NA NA NA NA NA NA NA NA NA NA 4201 5574 False False Inf 19.3978123032356 Inf 0 0 0.00017741953847001 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 46 0 13328 21313 0.00343950949603707 0.00251922040524703 0.00458518837381406 1 0.999826933785262 1 1 0.922938172948099 1 NA NA NA NA NA NA NA NA NA NA 3368 4479 False False 0 0 0 0 0 0 0 Inf 19.1447127506139 Inf 0 0 0.0002767383705975 1 0.999826933785262 1 3 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Glu114Ala hadA_p.Glu114Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 51.349017027227 1 2027.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 62.0933648450895 1 1642.5 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Glu19Lys hadA_p.Glu19Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4191 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3359 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Glu23Asp hadA_p.Glu23Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Gly100Ser hadA_p.Gly100Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4166 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Gly117Asp hadA_p.Gly117Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Gly150Arg hadA_p.Gly150Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Gly44Asp hadA_p.Gly44Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Gly49Glu hadA_p.Gly49Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4192 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3360 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Gly64Ala hadA_p.Gly64Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4193 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3361 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Gly64Cys hadA_p.Gly64Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 4176 5574 False False Inf 0.869878292971449 Inf 0 0 0.000176976922618654 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 13370 21313 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 1 0.999826933785262 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3345 4479 False False 0 0 0 0 0 0 0 Inf 1.05210128917758 Inf 0 0 0.000275869155324334 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.His11Arg hadA_p.His11Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4169 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3339 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.His11Tyr hadA_p.His11Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Ile120Val hadA_p.Ile120Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Ile7Val hadA_p.Ile7Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Ile84Val hadA_p.Ile84Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Leu134Val hadA_p.Leu134Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Lys102Arg hadA_p.Lys102Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4184 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3352 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Lys102Glu hadA_p.Lys102Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3367 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Lys66Asn hadA_p.Lys66Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 9 0 20837 27468 0.000431737503597812 0.000197436276106449 0.000819413341228355 1 0.999865711673152 1 1 0.663732883120057 1 NA NA NA NA NA NA NA NA NA NA 4186 5574 False False Inf 2.60134945111117 Inf 0 0 0.000177019385846931 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 6 0 13368 21313 0.000448631673396141 0.000164657143425453 0.000976224581517196 1 0.999826933785262 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 3354 4479 False False 0 0 0 0 0 0 0 Inf 1.87681913692541 Inf 0 0 0.00027591042269331 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Lys66Glu hadA_p.Lys66Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.658815063564403 0.011171855707321 12.6567401482543 1 2027.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Lys66Thr hadA_p.Lys66Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Pro15Ser hadA_p.Pro15Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Pro56Ser hadA_p.Pro56Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Pro96Ser hadA_p.Pro96Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Ser111Ala hadA_p.Ser111Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4162 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3333 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Ser154Tyr hadA_p.Ser154Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4180 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3348 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Thr128Ser hadA_p.Thr128Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Tyr14His hadA_p.Tyr14His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4187 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3355 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Tyr28Cys hadA_p.Tyr28Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4157 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3329 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Tyr39Asn hadA_p.Tyr39Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 4 20844 27464 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999854376001165 0.999627187086024 0.999960320981843 0.333333333333333 0.0432718682927417 0.777221904496487 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4170 5574 False False 0.658798695068125 0.0595601499680727 4.59736120623929 0 0 0.000176959943030976 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3340 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Val112Leu hadA_p.Val112Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4185 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3353 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Val20Ala hadA_p.Val20Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4159 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3330 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Val30Gly hadA_p.Val30Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4194 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3362 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Val32Ile hadA_p.Val32Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Val87Leu hadA_p.Val87Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4203 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid hadA p.Val98Ala hadA_p.Val98Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4163 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3334 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA c.-10_-9insAGG inhA_c.-10_-9insAGG 1 upstream_gene_variant 1674192 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2881 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA c.-100C>A inhA_c.-100C>A 1 upstream_gene_variant 1674102 1 7 5 2 43 3 20803 27465 0.00206274585052288 0.00149320926905043 0.00277751050043065 0.999890782000873 0.99968085216583 0.999977476056514 0.934782608695652 0.821035611127248 0.986343228086554 0.714285714285714 0.290420863737342 0.963307433823914 0.625 0.244863216366551 0.914766585862746 3.3006056818728 0.540278868117295 34.6675683428112 0.14872770665307 364 5574 False False 18.9234725760707 6.05502294820299 95.4183802768528 0.000240292195309496 7.80266777100348e-05 0.000560671977360347 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 16 0 13358 21313 0.00119635112905637 0.00068396778211822 0.00194207416051199 1 0.999826933785262 1 1 0.794092785792177 1 1 0.025 1 1 0.025 1 Inf 0.0409075713728292 Inf 0.385296492847254 473 4479 False False 0 0 0 0 0 0 0 Inf 6.15056952060403 Inf 7.48559023879032e-05 1.89518556728124e-06 0.000416999037045297 1 0.999826933785262 1 3 3) Uncertain significance No change no 1 +Isoniazid inhA c.102C>T inhA_c.102C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.-106G>A inhA_c.-106G>A 1 upstream_gene_variant 1674096 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-11_-10insAAG inhA_c.-11_-10insAAG 1 upstream_gene_variant 1674191 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2895 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA c.-11_-10insAAGG inhA_c.-11_-10insAAGG 1 upstream_gene_variant 1674191 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2896 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-11_-10insAAGGA inhA_c.-11_-10insAAGGA 1 upstream_gene_variant 1674191 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2859 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2334 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-110C>G inhA_c.-110C>G 1 upstream_gene_variant 1674092 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-112C>T inhA_c.-112C>T 1 upstream_gene_variant 1674090 1 9 0 9 2 9 20844 27459 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999672346002621 0.99937810218515 0.999850165132458 0.181818181818181 0.0228311982999596 0.517755852360172 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.667512768116361 0.012861862288912 138 5574 False False 0.292746113989637 0.0307804028975754 1.41460768720699 0 0 0.000176959943030976 0.999672346002621 0.99937810218515 0.999850165132458 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-11C>A inhA_c.-11C>A 1 upstream_gene_variant 1674191 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2871 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2344 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-120G>A inhA_c.-120G>A 1 upstream_gene_variant 1674082 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2862 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2337 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.123C>T inhA_c.123C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.126C>T inhA_c.126C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.43785249906968 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 5 13374 21308 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.73894646374006 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.-127C>A inhA_c.-127C>A 1 upstream_gene_variant 1674075 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2876 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2350 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.138G>A inhA_c.138G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 6 20846 27462 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.11900921779861 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.41420404242617 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.-140C>A inhA_c.-140C>A 1 upstream_gene_variant 1674062 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2878 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-14A>G inhA_c.-14A>G 1 upstream_gene_variant 1674188 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.150C>T inhA_c.150C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.-154G>A inhA_c.-154G>A 1 upstream_gene_variant 1674048 1 194 136 58 745 64 20101 27404 0.0357382711311522 0.0332592068793663 0.0383478644914445 0.99767001601864 0.997025622876796 0.998205180195353 0.92088998763906 0.9000986481111 0.938545299081236 0.701030927835051 0.631298907793497 0.764501149066127 0.68 0.610530114938341 0.744038812360042 3.19673922553175 2.33284665167019 4.42758308447243 7.86238576999484e-15 10 5574 True False 15.8698416745435 12.2715652601671 20.8315939993026 0.00672036369027029 0.00564132500581181 0.00794454666365718 0.99767001601864 0.997025622876796 0.998205180195353 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 161 107 54 520 60 12854 21253 0.0388814116943322 0.035668459407359 0.0422969292912083 0.997184816778492 0.996377766664424 0.9978510520541 0.896551724137931 0.868851087792916 0.920126232555147 0.664596273291925 0.58603415523357 0.736971196432387 0.640718562874251 0.562962560052354 0.713382010212576 3.27621175711264 2.33869636572943 4.63600829924268 2.83713073883097e-13 9 4479 True False 0 0 0 0 0 0 0 14.3295990871842 10.9390555301988 19.0619834545612 0.00825553583828408 0.0067704024051655 0.00996737619439835 0.997184816778492 0.996377766664424 0.9978510520541 92 Assoc w R Marker of R 1) Assoc w R Alias fabG1_p.Leu203Leu. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance) No change yes F, H 1 +Isoniazid inhA c.156C>T inhA_c.156C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.-156C>T inhA_c.-156C>T 1 upstream_gene_variant 1674046 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-158C>T inhA_c.-158C>T 1 upstream_gene_variant 1674044 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.159G>T inhA_c.159G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.-159G>T inhA_c.-159G>T 1 upstream_gene_variant 1674043 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-160G>A inhA_c.-160G>A 1 upstream_gene_variant 1674042 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-160G>C inhA_c.-160G>C 1 upstream_gene_variant 1674042 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.162G>T inhA_c.162G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.-16C>G inhA_c.-16C>G 1 upstream_gene_variant 1674186 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.171G>A inhA_c.171G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.-173G>T inhA_c.-173G>T 1 upstream_gene_variant 1674029 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.174C>A inhA_c.174C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.18865318395302 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.-176A>C inhA_c.-176A>C 1 upstream_gene_variant 1674026 1 7 4 3 16 3 20830 27465 0.000767533339729444 0.000438773245501675 0.00124612759964746 0.999890782000873 0.99968085216583 0.999977476056514 0.842105263157894 0.604215448733325 0.966173750998235 0.571428571428571 0.184051567640083 0.901011721557492 0.571428571428571 0.184051567640083 0.901011721557492 1.75804128660585 0.297363805631624 12.0048364266158 0.473899472010738 830 5574 False False 7.03216514642342 2.0124584049009 37.6639091237025 0.000191993856196601 5.23142622123071e-05 0.000491506894552512 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 4 1 9 1 13365 21312 0.000672947510094212 0.000307759154923187 0.00127707788784856 0.999953080279641 0.999738608085756 0.999998812096234 0.9 0.554983882971804 0.997471421455538 0.8 0.28358206388191 0.994949236620532 0.8 0.28358206388191 0.994949236620532 6.37845117845117 0.631082524096733 313.630454411632 0.0763366604176468 147 4479 False False 0 0 0 0 0 0 0 14.3515151515151 1.98814481377699 627.199072547492 0.00029919964096043 8.15276566733007e-05 0.000765891101882231 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance No change no 1 +Isoniazid inhA c.-180G>A inhA_c.-180G>A 1 upstream_gene_variant 1674022 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-181G>A inhA_c.-181G>A 1 upstream_gene_variant 1674021 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-186G>A inhA_c.-186G>A 1 upstream_gene_variant 1674016 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-187C>T inhA_c.-187C>T 1 upstream_gene_variant 1674015 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-18C>A inhA_c.-18C>A 1 upstream_gene_variant 1674184 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2853 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2328 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA c.-18C>T inhA_c.-18C>T 1 upstream_gene_variant 1674184 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2905 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2369 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-19_-18insCACAACAC inhA_c.-19_-18insCACAACAC 1 upstream_gene_variant 1674183 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2910 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2374 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA c.-1C>T inhA_c.-1C>T 1 upstream_gene_variant 1674201 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2926 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2384 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA c.-202C>T inhA_c.-202C>T 1 upstream_gene_variant 1674000 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-204G>A inhA_c.-204G>A 1 upstream_gene_variant 1673998 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA c.-205C>T inhA_c.-205C>T 1 upstream_gene_variant 1673997 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2889 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2359 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-208C>T inhA_c.-208C>T 1 upstream_gene_variant 1673994 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-20G>A inhA_c.-20G>A 1 upstream_gene_variant 1674182 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.211C>T inhA_c.211C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.213G>A inhA_c.213G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 7 1 20839 27467 0.000335795836131632 0.000135017659185429 0.000691744589626827 0.999963594000291 0.999797175631493 0.999999078280314 0.875 0.473490329124793 0.996840276468748 NA NA NA NA NA NA NA NA NA NA NA NA False False 9.22640241854215 1.18513781610454 415.029346412368 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 6 1 13368 21312 0.000448631673396141 0.000164657143425453 0.000976224581517196 0.999953080279641 0.999738608085756 0.999998812096234 0.857142857142857 0.421276802956804 0.996389703138099 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 9.56552962298025 1.16026312817987 439.068355223953 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.216C>T inhA_c.216C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.-217C>T inhA_c.-217C>T 1 upstream_gene_variant 1673985 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA c.222G>A inhA_c.222G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.228C>T inhA_c.228C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.-229G>C inhA_c.-229G>C 1 upstream_gene_variant 1673973 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2909 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2373 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-232C>T inhA_c.-232C>T 1 upstream_gene_variant 1673970 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.237C>T inhA_c.237C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.240G>A inhA_c.240G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.243G>T inhA_c.243G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.249G>A inhA_c.249G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.-25_-24insCACTGACACAACA inhA_c.-25_-24insCACTGACACAACA 1 upstream_gene_variant 1674177 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2924 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2383 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA c.-25C>T inhA_c.-25C>T 1 upstream_gene_variant 1674177 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.264C>T inhA_c.264C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 8 20844 27460 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.99970875200233 0.999426206431739 0.999874251669172 0.2 0.0252107263268333 0.556095462307641 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.329351372097486 0.0340635477373695 1.6506834450398 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 2 7 13372 21306 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.99967156195749 0.999323409938814 0.999867941002665 0.222222222222222 0.0281449734778982 0.600093573716312 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.455236955685654 0.0461387128464925 2.39147917078199 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.267C>T inhA_c.267C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.247471899512553 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.273G>A inhA_c.273G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.-277C>T inhA_c.-277C>T 1 upstream_gene_variant 1673925 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-282A>G inhA_c.-282A>G 1 upstream_gene_variant 1673920 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2854 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2329 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-285G>T inhA_c.-285G>T 1 upstream_gene_variant 1673917 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-289C>T inhA_c.-289C>T 1 upstream_gene_variant 1673913 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2879 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2352 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA c.291C>T inhA_c.291C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 20 20845 27448 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999271880005825 0.998875700613314 0.999555190458412 0.0476190476190476 0.00120488344836351 0.238159909936821 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.0658383305349004 0.00159270996657629 0.411717550396138 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 15 13373 21298 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999296204194623 0.998839461100611 0.999606039023746 0.0625 0.00158111172276588 0.302320738434531 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.106174131957426 0.00252607251575667 0.690295349767496 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.-292G>A inhA_c.-292G>A 1 upstream_gene_variant 1673910 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2863 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2338 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA c.-295C>T inhA_c.-295C>T 1 upstream_gene_variant 1673907 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA c.303C>T inhA_c.303C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.31C>T inhA_c.31C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.321G>A inhA_c.321G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.324C>T inhA_c.324C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.333G>C inhA_c.333G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.-334C>G inhA_c.-334C>G 1 upstream_gene_variant 1673868 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA c.-337C>T inhA_c.-337C>T 1 upstream_gene_variant 1673865 1 14 0 14 38 16 20808 27452 0.00182289168185743 0.00129029962509865 0.00250121141611544 0.99941750400466 0.999054234895718 0.999667017718464 0.703703703703703 0.563909270702599 0.82021962548874 0 0 0.231635761650116 0 0 0.205907214207822 0 0 0.397765504621177 0.000520580563155562 70 5574 True False 3.13333813917723 1.70539667389857 6.02070007723719 0 0 0.000177266074964553 0.99941750400466 0.999054234895718 0.999667017718464 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 14 8 13360 21305 0.00104680723792433 0.000572413688832994 0.00175574154681136 0.999624642237132 0.999260530264256 0.999837933676441 0.636363636363636 0.406576668825646 0.828020562353667 0 0 0.4592581264399 0 0 0.369416647552819 0 0 1.35464627999118 0.0885083029073872 191 4479 False False 0 0 0 0 0 0 0 2.7906998502994 1.09219710430555 7.67982410236522 0 0 0.000276075615707154 0.999624642237132 0.999260530264256 0.999837933676441 2 3) Uncertain significance No change no 1 +Isoniazid inhA c.-343G>T inhA_c.-343G>T 1 upstream_gene_variant 1673859 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-351A>G inhA_c.-351A>G 1 upstream_gene_variant 1673851 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2880 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2353 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.351C>T inhA_c.351C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.-352C>T inhA_c.-352C>T 1 upstream_gene_variant 1673850 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA c.354G>A inhA_c.354G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.357C>A inhA_c.357C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.-358G>T inhA_c.-358G>T 1 upstream_gene_variant 1673844 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-360A>G inhA_c.-360A>G 1 upstream_gene_variant 1673842 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2864 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2339 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA c.363C>T inhA_c.363C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.369G>A inhA_c.369G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.99604811372315 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.-375A>C inhA_c.-375A>C 1 upstream_gene_variant 1673827 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.384T>G inhA_c.384T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.544526627735454 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.-385C>T inhA_c.-385C>T 1 upstream_gene_variant 1673817 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA c.-386G>A inhA_c.-386G>A 1 upstream_gene_variant 1673816 1 29 1 28 5 30 20841 27438 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.998907820008737 0.998441209231564 0.999262993209016 0.142857142857142 0.0480607784036389 0.302571351690951 0.0344827586206896 0.000872646883579922 0.177644295488722 0.032258064516129 0.000816370071846613 0.167021116230227 0.0470192683378231 0.00115421726255467 0.284455262670615 2.00394248883356e-06 37 5574 True False 0.219423252243174 0.0664559910248107 0.571313285464559 4.79800403032338e-05 1.21474870966795e-06 0.000267298357449221 0.998907820008737 0.998441209231564 0.999262993209016 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 25 1 24 5 25 13369 21288 0.000373859727830118 0.000121402023062639 0.000872246401868143 0.998827006991038 0.998268914575298 0.99924076142744 0.166666666666666 0.0564216964680715 0.347211698834143 0.04 0.00101219969931084 0.203516913922414 0.0384615384615384 0.00097328789333503 0.196369646762539 0.0663475203829755 0.0016175337257616 0.406990451727268 0.000114171928504944 38 4479 True False 0 0 0 0 0 0 0 0.318468097838282 0.0951927654928965 0.847254697510498 7.47943156320119e-05 1.89362632857505e-06 0.000416656014965588 0.998827006991038 0.998268914575298 0.99924076142744 3 3) Uncertain significance No change no 1 +Isoniazid inhA c.-391G>T inhA_c.-391G>T 1 upstream_gene_variant 1673811 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2887 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2357 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA c.-395C>T inhA_c.-395C>T 1 upstream_gene_variant 1673807 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2932 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2388 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-3C>G inhA_c.-3C>G 1 upstream_gene_variant 1674199 1 1 0 1 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 51.3446878573018 1 2027.5 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 62.0858160113928 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-40C>T inhA_c.-40C>T 1 upstream_gene_variant 1674162 1 2 0 2 153 636 20693 26832 0.00733953756116281 0.0062259742733587 0.00859360757996474 0.976845784185233 0.974997782113564 0.978591943886018 0.193916349809885 0.16688099280778 0.223260634519746 0 0 0.841886116991581 0 0 0.00578333667692927 0 0 6.90472494755409 0.508337365907367 NA NA False True 0.311934853550877 0.259491292159151 0.373099505416586 0 0 0.000178251131826064 0.976845784185233 0.974997782113564 0.978591943886018 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 1 0 1 136 604 13238 20709 0.0101689845969792 0.0085384987052836 0.0120175640337082 0.971660488903486 0.969343858211453 0.973847245657524 0.183783783783783 0.156508149515206 0.213606367709306 0 0 0.975 0 0 0.00608880395815097 0 0 60.9558344295608 1 NA NA False True 0 1 1 0 0 1 1 0.352240039460953 0.289879614549857 0.425511309701317 0 0 0.000278619544741647 0.971660488903486 0.969343858211453 0.973847245657524 22 Not assoc w R 5) Not assoc w R No change yes 1 +Isoniazid inhA c.-415G>A inhA_c.-415G>A 1 upstream_gene_variant 1673787 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-415G>T inhA_c.-415G>T 1 upstream_gene_variant 1673787 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2913 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2376 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.420C>A inhA_c.420C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.420C>T inhA_c.420C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.-424C>T inhA_c.-424C>T 1 upstream_gene_variant 1673778 2 1 0 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 51.3533466119536 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 0 1 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 62.1009148060541 1 1642.5 4479 False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 0 0 0.000275827900298067 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance No change no 1 +Isoniazid inhA c.-431C>T inhA_c.-431C>T 1 upstream_gene_variant 1673771 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2872 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2345 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-436C>T inhA_c.-436C>T 1 upstream_gene_variant 1673766 1 5 0 5 0 8 20846 27460 0 0 0.00017694296670111 0.99970875200233 0.999426206431739 0.999874251669172 0 0 0.369416647552819 0 0 0.521823750104981 0 0 0.369416647552819 0 0 1.43769496985327 0.0743287213697913 227.5 5574 False False 0 0 0.771808536885009 0 0 0.00017694296670111 0.99970875200233 0.999426206431739 0.999874251669172 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 7 13374 21306 0 0 0.000275786657608973 0.99967156195749 0.999323409938814 0.999867941002665 0 0 0.409616397225003 0 0 0.521823750104981 0 0 0.409616397225003 0 0 1.73878331464646 0.163959837077221 234.5 4479 False False 0 0 0 0 0 0 0 0 0 1.10552510564584 0 0 0.000275786657608973 0.99967156195749 0.999323409938814 0.999867941002665 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-438A>G inhA_c.-438A>G 1 upstream_gene_variant 1673764 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA c.-460C>T inhA_c.-460C>T 1 upstream_gene_variant 1673742 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-466G>T inhA_c.-466G>T 1 upstream_gene_variant 1673736 1 4 0 4 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 1.99604811372315 0.139118032244638 322.5 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.471C>T inhA_c.471C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.-472C>T inhA_c.-472C>T 1 upstream_gene_variant 1673730 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.474C>T inhA_c.474C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.-475C>T inhA_c.-475C>T 1 upstream_gene_variant 1673727 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA c.477C>T inhA_c.477C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 7 20844 27461 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999745158002038 0.999474999027776 0.999897534357495 0.222222222222222 0.0281449734778982 0.600093573716312 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.376415275379005 0.0381509889597215 1.97729867984898 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 4 13373 21309 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999812321118566 0.999519537882235 0.999948861529775 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.398358633066626 0.00809276091420046 4.02622197901862 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.-478A>C inhA_c.-478A>C 1 upstream_gene_variant 1673724 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.486G>A inhA_c.486G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.99604811372315 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.85651838973546 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.-486G>A inhA_c.-486G>A 1 upstream_gene_variant 1673716 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2928 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2386 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-486G>T inhA_c.-486G>T 1 upstream_gene_variant 1673716 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2885 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA c.-487C>G inhA_c.-487C>G 1 upstream_gene_variant 1673715 1 11 0 11 2 11 20844 27457 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999599534003203 0.9992835689522 0.999800072407065 0.153846153846153 0.0192066719825284 0.454471055676557 0 0 0.284914152918154 0 0 0.284914152918154 0 0 0.524919694855171 0.00349760191700632 102.5 5574 False False 0.239502102196402 0.02578903914769 1.09755702800922 0 0 0.000176959943030976 0.999599534003203 0.9992835689522 0.999800072407065 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 0 11 1 11 13373 21302 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999483883076056 0.999076712346733 0.999742329032819 0.0833333333333333 0.00210759323186022 0.384796165150944 0 0 0.284914152918154 0 0 0.284914152918154 0 0 0.634818992426303 0.0091309212802995 88 4479 False False 0 0 0 0 0 0 0 0.144810099046246 0.00336819644582784 0.996572767671761 0 0 0.000275807277411719 0.999483883076056 0.999076712346733 0.999742329032819 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.489C>A inhA_c.489C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.489C>T inhA_c.489C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.658815063564403 0.011171855707321 12.6567401482543 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.-489T>G inhA_c.-489T>G 1 upstream_gene_variant 1673713 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA c.-490A>C inhA_c.-490A>C 1 upstream_gene_variant 1673712 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA c.-49G>A inhA_c.-49G>A 1 upstream_gene_variant 1674153 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA c.-510C>G inhA_c.-510C>G 1 upstream_gene_variant 1673692 0 0 0 0 5 0 20841 27468 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 1 0.999865711673152 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 2907 5574 False False Inf 1.20760984683633 Inf 0 0 0.000176985413634466 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2371 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-511G>A inhA_c.-511G>A 1 upstream_gene_variant 1673691 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-517C>G inhA_c.-517C>G 1 upstream_gene_variant 1673685 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.51C>G inhA_c.51C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.-520G>C inhA_c.-520G>C 1 upstream_gene_variant 1673682 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-520G>T inhA_c.-520G>T 1 upstream_gene_variant 1673682 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-522C>G inhA_c.-522C>G 1 upstream_gene_variant 1673680 0 0 0 0 0 55 20846 27413 0 0 0.00017694296670111 0.997997670016018 0.997394479593214 0.99849122574834 0 0 0.0648707608254246 NA NA NA 0 0 0.0648707608254246 NA NA NA NA NA NA False True 0 0 0.0912386929334179 0 0 0.00017694296670111 0.997997670016018 0.997394479593214 0.99849122574834 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 0 45 13374 21268 0 0 0.000275786657608973 0.997888612583869 0.997175806123482 0.998459535429248 0 0 0.078705100406843 NA NA NA 0 0 0.078705100406843 NA NA NA NA NA NA False True 1 1 1 0 0 1 0 0 0 0.135875272375293 0 0 0.000275786657608973 0.997888612583869 0.997175806123482 0.998459535429248 7 Not assoc w R 5) Not assoc w R No change yes 1 +Isoniazid inhA c.522C>T inhA_c.522C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.-523T>C inhA_c.-523T>C 1 upstream_gene_variant 1673679 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-529C>A inhA_c.-529C>A 1 upstream_gene_variant 1673673 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.537C>A inhA_c.537C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.537C>T inhA_c.537C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.18865318395302 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.85651838973546 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.540C>T inhA_c.540C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.-541G>A inhA_c.-541G>A 1 upstream_gene_variant 1673661 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-541G>C inhA_c.-541G>C 1 upstream_gene_variant 1673661 1 1 0 1 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 51.349017027227 1 2027.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance No change no 1 +Isoniazid inhA c.-542C>T inhA_c.-542C>T 1 upstream_gene_variant 1673660 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-545C>T inhA_c.-545C>T 1 upstream_gene_variant 1673657 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2873 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2346 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA c.-547C>T inhA_c.-547C>T 1 upstream_gene_variant 1673655 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2855 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2330 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.549T>A inhA_c.549T>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.-552G>A inhA_c.-552G>A 1 upstream_gene_variant 1673650 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.555T>C inhA_c.555T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.567T>G inhA_c.567T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.-574C>T inhA_c.-574C>T 1 upstream_gene_variant 1673628 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2856 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2331 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA c.-580C>G inhA_c.-580C>G 1 upstream_gene_variant 1673622 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.582C>T inhA_c.582C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.-589C>T inhA_c.-589C>T 1 upstream_gene_variant 1673613 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.591G>A inhA_c.591G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.-594G>A inhA_c.-594G>A 1 upstream_gene_variant 1673608 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA c.-598G>A inhA_c.-598G>A 1 upstream_gene_variant 1673604 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-602G>A inhA_c.-602G>A 1 upstream_gene_variant 1673600 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2865 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-611C>T inhA_c.-611C>T 1 upstream_gene_variant 1673591 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance No change no 1 +Isoniazid inhA c.-612G>A inhA_c.-612G>A 1 upstream_gene_variant 1673590 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.615T>C inhA_c.615T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.99604811372315 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.41420404242617 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.-616C>T inhA_c.-616C>T 1 upstream_gene_variant 1673586 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2866 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-618T>C inhA_c.-618T>C 1 upstream_gene_variant 1673584 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2897 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-622T>C inhA_c.-622T>C 1 upstream_gene_variant 1673580 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance No change no 1 +Isoniazid inhA c.-622T>G inhA_c.-622T>G 1 upstream_gene_variant 1673580 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2927 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2385 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA c.624C>T inhA_c.624C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.-628C>T inhA_c.-628C>T 1 upstream_gene_variant 1673574 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA c.-631C>T inhA_c.-631C>T 1 upstream_gene_variant 1673571 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA c.636C>T inhA_c.636C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.639C>T inhA_c.639C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.-641A>G inhA_c.-641A>G 1 upstream_gene_variant 1673561 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-646C>T inhA_c.-646C>T 1 upstream_gene_variant 1673556 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2937 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2390 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA c.648G>A inhA_c.648G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.-648G>T inhA_c.-648G>T 1 upstream_gene_variant 1673554 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2857 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2332 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA c.649C>T inhA_c.649C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.-649C>T inhA_c.-649C>T 1 upstream_gene_variant 1673553 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.654C>G inhA_c.654C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.654C>T inhA_c.654C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.-661G>A inhA_c.-661G>A 1 upstream_gene_variant 1673541 1 1 0 1 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 51.349017027227 1 2027.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 62.0933648450895 1 1642.5 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA c.663C>T inhA_c.663C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.-664G>A inhA_c.-664G>A 1 upstream_gene_variant 1673538 2 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-674C>A inhA_c.-674C>A 1 upstream_gene_variant 1673528 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-676G>A inhA_c.-676G>A 1 upstream_gene_variant 1673526 1 3 0 3 2 3 20844 27465 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999890782000873 0.99968085216583 0.999977476056514 0.4 0.0527449505263169 0.853367200365326 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18895916093986 0.264083883232833 556.5 5574 False False 0.878430243715217 0.0733354884838472 7.66963698207431 0 0 0.000176959943030976 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 2 3 13372 21310 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999859240838924 0.999588697652472 0.999970971136275 0.4 0.0527449505263169 0.853367200365326 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85709530412199 0.289291791934617 400.5 4479 False False 0 0 0 0 0 0 0 1.06241898494366 0.0886985485353837 9.27715037564111 0 0 0.000275827900298067 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-67C>T inhA_c.-67C>T 1 upstream_gene_variant 1674135 1 2 1 1 16 1 20830 27467 0.000767533339729444 0.000438773245501675 0.00124612759964746 0.999963594000291 0.999797175631493 0.999999078280314 0.941176470588235 0.713110603332779 0.998511825608733 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.31862698031685 0.0168048388018241 103.431483666134 1 1253.5 5574 False False 21.0980316850696 3.27696052461101 881.196612561466 4.80053766021794e-05 1.21539016844027e-06 0.000267439491302368 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 8 1 13366 21312 0.000598175564528189 0.000258283997825234 0.00117830226263269 0.999953080279641 0.999738608085756 0.999998812096234 0.888888888888888 0.517503485082663 0.9971908632534 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.59449349094717 0.020311188872658 125.049201658061 1 1642.5 4479 False False 0 0 0 0 0 0 0 12.7559479275774 1.70975577844451 564.516212294525 7.48111019675319e-05 1.89405132098963e-06 0.000416749510461935 0.999953080279641 0.999738608085756 0.999998812096234 6 3) Uncertain significance No change no 1 +Isoniazid inhA c.684C>T inhA_c.684C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.18865318395302 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.-692A>G inhA_c.-692A>G 1 upstream_gene_variant 1673510 1 4 1 3 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.439194051331254 0.00837049629364692 5.4704842261679 0.638942720978879 1228.5 5574 False False 0.439194051331254 0.00837049629364692 5.4704842261679 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-700C>T inhA_c.-700C>T 1 upstream_gene_variant 1673502 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-703T>C inhA_c.-703T>C 1 upstream_gene_variant 1673499 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-705G>A inhA_c.-705G>A 1 upstream_gene_variant 1673497 1 2 0 2 3 2 20843 27466 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999927188000582 0.999737003036386 0.999991182007438 0.6 0.146632799634673 0.947255049473683 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01699856622015 0.509392482788101 1176.5 5574 False False 1.97663484143357 0.226402568392661 23.6672561646805 0 0 0.00017696843241753 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-706G>A inhA_c.-706G>A 1 upstream_gene_variant 1673496 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA c.714C>A inhA_c.714C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.-715T>C inhA_c.-715T>C 1 upstream_gene_variant 1673487 1 2 0 2 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01632529799099 0.509386028876591 1135.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-718C>T inhA_c.-718C>T 1 upstream_gene_variant 1673484 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-723G>A inhA_c.-723G>A 1 upstream_gene_variant 1673479 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.726G>A inhA_c.726G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.-727A>G inhA_c.-727A>G 1 upstream_gene_variant 1673475 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2890 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-728C>G inhA_c.-728C>G 1 upstream_gene_variant 1673474 0 0 0 0 9 0 20837 27468 0.000431737503597812 0.000197436276106449 0.000819413341228355 1 0.999865711673152 1 1 0.663732883120057 1 NA NA NA NA NA NA NA NA NA NA 2938 5574 False False Inf 2.60134945111117 Inf 0 0 0.000177019385846931 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2391 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 7 3) Uncertain significance No change no 1 +Isoniazid inhA c.-728C>T inhA_c.-728C>T 1 upstream_gene_variant 1673474 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA c.-730C>T inhA_c.-730C>T 1 upstream_gene_variant 1673472 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.732G>A inhA_c.732G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.-734A>G inhA_c.-734A>G 1 upstream_gene_variant 1673468 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2935 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA c.738G>A inhA_c.738G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.-741G>T inhA_c.-741G>T 1 upstream_gene_variant 1673461 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA c.-744G>A inhA_c.-744G>A 1 upstream_gene_variant 1673458 1 7 0 7 0 7 20846 27461 0 0 0.00017694296670111 0.999745158002038 0.999474999027776 0.999897534357495 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.914121240039481 0.0219749245408003 156 5574 False False 0 0 0.914121240039481 0 0 0.00017694296670111 0.999745158002038 0.999474999027776 0.999897534357495 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 7 13374 21306 0 0 0.000275786657608973 0.99967156195749 0.999323409938814 0.999867941002665 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 1.10552510564584 0.0484388314759391 130.5 4479 False False 0 0 0 0 0 0 0 0 0 1.10552510564584 0 0 0.000275786657608973 0.99967156195749 0.999323409938814 0.999867941002665 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-752C>A inhA_c.-752C>A 1 upstream_gene_variant 1673450 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2933 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-752C>G inhA_c.-752C>G 1 upstream_gene_variant 1673450 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2882 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2354 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-752C>T inhA_c.-752C>T 1 upstream_gene_variant 1673450 1 9 1 8 2 8 20844 27460 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.99970875200233 0.999426206431739 0.999874251669172 0.2 0.0252107263268333 0.556095462307641 0.111111111111111 0.00280913674659921 0.482496514917337 0.111111111111111 0.00280913674659921 0.482496514917337 0.164675686048743 0.00371531310870844 1.22851949923573 0.0876215428892141 292 5574 False False 0.329351372097486 0.0340635477373695 1.6506834450398 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 0.99970875200233 0.999426206431739 0.999874251669172 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 1 4 2 4 13372 21309 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999812321118566 0.999519537882235 0.999948861529775 0.333333333333333 0.0432718682927417 0.777221904496487 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 0.398388423571642 0.00809336568447121 4.02652314751319 0.655132754654363 996 4479 False False 0 0 0 0 0 0 0 0.796776847143284 0.0720475461928349 5.56077695166295 7.47775368279368e-05 1.89320152683959e-06 0.000416562561410248 0.999812321118566 0.999519537882235 0.999948861529775 2 3) Uncertain significance No change no 1 +Isoniazid inhA c.-756G>A inhA_c.-756G>A 1 upstream_gene_variant 1673446 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA c.75C>A inhA_c.75C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.247471899512553 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.762G>A inhA_c.762G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.-764G>A inhA_c.-764G>A 1 upstream_gene_variant 1673438 1 1 0 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 51.3533466119536 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-766C>A inhA_c.-766C>A 1 upstream_gene_variant 1673436 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2858 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2333 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA c.-767T>C inhA_c.-767T>C 1 upstream_gene_variant 1673435 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2867 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2340 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-76G>A inhA_c.-76G>A 1 upstream_gene_variant 1674126 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance No change no 1 +Isoniazid inhA c.-770T>A inhA_c.-770T>A 1 upstream_gene_variant 1673432 1 17 12 5 166 8 20680 27460 0.00796315839969298 0.00680164362644315 0.00926485695183265 0.99970875200233 0.999426206431739 0.999874251669172 0.954022988505747 0.911419313755657 0.979944235012798 0.705882352941176 0.440417281245662 0.89686448562968 0.6 0.360542587307489 0.808809939274692 3.18684719535783 1.04483202667106 11.5464411595993 0.0266238590281171 173 5574 False False 27.5529497098646 13.6601280577168 64.885713857043 0.0005799342741156 0.000299695262529016 0.00101280910128856 0.99970875200233 0.999426206431739 0.999874251669172 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 14 9 5 91 6 13283 21307 0.00680424704650815 0.00548178976840049 0.00834762639917274 0.999718481677849 0.999387354605726 0.999896680954833 0.938144329896907 0.870216339001163 0.976964002717552 0.642857142857142 0.351380110615991 0.87240157014084 0.6 0.322869766206281 0.836635676140486 2.88734472634194 0.868722668870486 10.9693993248319 0.0559903837134369 141 4479 False False 0 0 0 0 0 0 0 24.32855278677 10.7538920677453 68.1574141999951 0.000677099006921456 0.000309658036947439 0.00128495394354497 0.999718481677849 0.999387354605726 0.999896680954833 67 Assoc w RI Marker of R WHO-endorsed gDST assay 2) Assoc w R - Interim Alias fabG1_c.-8T>A. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance) No change yes WHO-end. gDST F, I 1 +Isoniazid inhA c.-770T>C inhA_c.-770T>C 1 upstream_gene_variant 1673432 1 24 10 14 388 17 20458 27451 0.018612683488439 0.0168213820405976 0.0205399513284281 0.999381098004951 0.999009262277189 0.999639426758727 0.958024691358024 0.933642589004973 0.975360777934188 0.416666666666666 0.221096905346678 0.633569354343637 0.37037037037037 0.194007158715135 0.576320427495704 0.958444478583299 0.380772702272104 2.32058223750872 1 2027.5 5574 False False 30.6251200450851 18.8711816068919 53.1242137027661 0.000488567520031268 0.00023431118505675 0.0008983089112201 0.999381098004951 0.999009262277189 0.999639426758727 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 20 9 11 201 12 13173 21301 0.0150291610587707 0.0130357849364298 0.0172374191276901 0.999436963355698 0.999016695060306 0.999709037985722 0.943661971830986 0.90365734320649 0.970553841572112 0.45 0.230577896775924 0.684721866959451 0.428571428571428 0.21819685688513 0.659793690719725 1.32301608662346 0.48443762440796 3.51287490895968 0.646181197333981 994 4479 False False 0 0 0 0 0 0 0 27.0850793289303 15.1552028671243 53.309687117259 0.000682749203459262 0.00031224242513154 0.00129567322588386 0.999436963355698 0.999016695060306 0.999709037985722 55 Assoc w RI Marker of R WHO-endorsed gDST assay 2) Assoc w R - Interim Alias fabG1_c.-8T>C. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance) No change yes WHO-end. gDST F, J 1 +Isoniazid inhA c.-770T>G inhA_c.-770T>G 1 upstream_gene_variant 1673432 1 3 3 0 19 0 20827 27468 0.000911445840928715 0.000548836318218138 0.00142297127227785 1 0.999865711673152 1 1 0.823533088193034 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.544944835107701 Inf 0.0802130063479926 276 5574 False False Inf 6.15281557358538 Inf 0.000144023043686989 2.97019989197563e-05 0.000420838186784513 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 6 0 13368 21313 0.000448631673396141 0.000164657143425453 0.000976224581517196 1 0.999826933785262 1 1 0.540741873560099 1 1 0.025 1 1 0.025 1 Inf 0.0408769722035076 Inf 0.385473732772043 479.5 4479 False False 0 0 0 0 0 0 0 Inf 1.87681913692541 Inf 7.47999102401077e-05 1.89376797152033e-06 0.000416687175469531 1 0.999826933785262 1 2 Marker of R WHO-endorsed gDST assay 2) Assoc w R - Interim Alias fabG1_c.-8T>G. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance) UP from Uncertain to AwRI yes WHO-end. gDST F, K 4 +Isoniazid inhA c.-771G>A inhA_c.-771G>A 1 upstream_gene_variant 1673431 0 0 0 0 5 0 20841 27468 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 1 0.999865711673152 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 2874 5574 False False Inf 1.20760984683633 Inf 0 0 0.000176985413634466 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2347 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 2 3) Uncertain significance No change no 1 +Isoniazid inhA c.777C>T inhA_c.777C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.-777C>T inhA_c.-777C>T 1 upstream_gene_variant 1673425 1 1112 976 136 4449 161 16397 27307 0.213422239278518 0.207876554970914 0.21904795069176 0.994138634046891 0.99316340913719 0.995006976120627 0.965075921908893 0.959364835822138 0.970187546595791 0.877697841726618 0.856986774563693 0.896385318820128 0.858399296394019 0.836768013513882 0.878156427092355 11.9514473594524 9.96806946890599 14.4222215705404 1.32614968861587e-259 3 5574 True False 46.0199479756371 39.2710122334902 54.3086350095898 0.0561791285327807 0.0528007982595569 0.0597069676360048 0.994138634046891 0.99316340913719 0.995006976120627 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 730 633 97 2976 113 10398 21200 0.222521310004486 0.215495558599208 0.229667991282605 0.994698071599493 0.993629041091926 0.995628522831882 0.963418582065393 0.956182829852728 0.96975856800893 0.867123287671232 0.840327333885659 0.890908414175953 0.8485254691689 0.820756424252325 0.873503490397435 13.3050963408902 10.7112691839411 16.6711315453634 1.57875459644027e-195 3 4479 True False 0 0 0 0 0 0 0 53.6958264608408 44.4123445599485 65.5219011924346 0.0573837367419091 0.0531155638040624 0.0618873460847544 0.994698071599493 0.993629041091926 0.995628522831882 616 Assoc w R Marker of R 1) Assoc w R Alias fabG1_c.-15C>T. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance) No change yes F, L 1 +Isoniazid inhA c.-778A>G inhA_c.-778A>G 1 upstream_gene_variant 1673424 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2914 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Assoc w RI Marker of R WHO-endorsed gDST assay 2) Assoc w R - Interim Alias fabG1_c.-16A>G. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance) no change yes WHO-end. gDST F, M 1 +Isoniazid inhA c.-779G>T inhA_c.-779G>T 1 upstream_gene_variant 1673423 1 56 33 23 339 26 20507 27442 0.0162621126355176 0.0145888637253057 0.0180721490485002 0.999053444007572 0.998613381560132 0.999381587946625 0.928767123287671 0.897367369343834 0.952943638740981 0.589285714285714 0.449764917401547 0.719028475615399 0.559322033898305 0.424036659239704 0.688448997593276 1.91999338507953 1.09346307574473 3.42572286740439 0.020739581124508 149 5574 False False 17.4477720553206 11.6899566544449 27.1175135028899 0.00160662122687439 0.00110617421459099 0.00225556049112711 0.999053444007572 0.998613381560132 0.999381587946625 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 34 18 16 122 19 13252 21294 0.00912217735905488 0.00758100826556867 0.0108822389430857 0.999108525313189 0.998608200368116 0.999463191365845 0.865248226950354 0.797590994342756 0.916880164621471 0.529411764705882 0.351292837051412 0.702213333581803 0.486486486486486 0.31921410648154 0.656003184334233 1.80770827044974 0.869798930694136 3.79068529307506 0.110723274361851 194 4479 False False 0 0 0 0 0 0 0 10.3176799529763 6.32685444779675 17.7311030498189 0.00135644310474755 0.000804106051480674 0.0021429209404041 0.999108525313189 0.998608200368116 0.999463191365845 178 Marker of R WHO-endorsed gDST assay 2) Assoc w R - Interim Alias fabG1_c.-17G>T. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance) UP from Uncertain to AwRI yes WHO-end. gDST F, N 4 +Isoniazid inhA c.780C>T inhA_c.780C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.-781G>T inhA_c.-781G>T 1 upstream_gene_variant 1673421 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA c.-782C>T inhA_c.-782C>T 1 upstream_gene_variant 1673420 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2362 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.783C>T inhA_c.783C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.-783G>A inhA_c.-783G>A 1 upstream_gene_variant 1673419 1 2 0 2 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01632529799099 0.509386028876591 1135.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48598624162872 0.526186417038858 925 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.786C>A inhA_c.786C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 5 20844 27463 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999817970001456 0.999575254267103 0.999940892797913 0.285714285714285 0.0366925661760855 0.709579136262657 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.527019765879869 0.0501829950712842 3.21985261870185 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.789C>T inhA_c.789C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.-789G>C inhA_c.-789G>C 1 upstream_gene_variant 1673413 1 2 0 2 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 7.01547785354097 0.509377906736075 843 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 8.48455543336434 0.526168130935474 674.5 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-792C>T inhA_c.-792C>T 1 upstream_gene_variant 1673410 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2886 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-793C>T inhA_c.-793C>T 1 upstream_gene_variant 1673409 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-794G>T inhA_c.-794G>T 1 upstream_gene_variant 1673408 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2920 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-796C>G inhA_c.-796C>G 1 upstream_gene_variant 1673406 1 1 0 1 10 1 20836 27467 0.000479708337330902 0.000230061997553563 0.000882023176671562 0.999963594000291 0.999797175631493 0.999999078280314 0.909090909090909 0.587220083011617 0.997701027786185 0 0 0.975 0 0 0.975 0 0 51.3730479462142 1 2027.5 5574 False False 13.1824726435016 1.87489573468025 570.603433894195 0 0 0.000177027880937939 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 4 1 13370 21312 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 0.999953080279641 0.999738608085756 0.999998812096234 0.8 0.28358206388191 0.994949236620532 0 0 0.975 0 0 0.975 0 0 62.1101953816142 1 1642.5 4479 False False 0 0 0 0 0 0 0 6.37606581899775 0.630846560224411 313.513380938872 0 0 0.000275869155324334 0.999953080279641 0.999738608085756 0.999998812096234 2 3) Uncertain significance No change no 1 +Isoniazid inhA c.-796C>T inhA_c.-796C>T 1 upstream_gene_variant 1673406 1 1 0 1 33 2 20813 27466 0.00158303751319197 0.00108993298100569 0.00222246155345815 0.999927188000582 0.999737003036386 0.999991182007438 0.942857142857142 0.80842859365476 0.99300323637169 0 0 0.975 0 0 0.841886116991581 0 0 51.4279027312939 1 1253.5 5574 False False 21.7743237399702 5.56776246726548 186.879643262492 0 0 0.000177223493316982 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 20 2 13354 21311 0.00149543891132047 0.000913684725149316 0.00230864386780147 0.999906160559283 0.999661061221376 0.999988635406343 0.909090909090909 0.708387258446066 0.988794413975849 0 0 0.975 0 0 0.841886116991581 0 0 62.1816251175163 1 1642.5 4479 False False 0 0 0 0 0 0 0 15.9585143028306 3.8754856357723 140.762033959198 0 0 0.000276199640337768 0.999906160559283 0.999661061221376 0.999988635406343 2 3) Uncertain significance No change no 1 +Isoniazid inhA c.-796delC inhA_c.-796delC 1 upstream_gene_variant 1673405 1 1 1 0 11 0 20835 27468 0.000527679171063993 0.000263444034397523 0.000943967185544106 1 0.999865711673152 1 1 0.715085847081845 1 1 0.025 1 1 0.025 1 Inf 0.0338021728163356 Inf 0.431351440874461 597.5 5574 False False Inf 3.30816067473776 Inf 4.79938567863313e-05 1.21509851230904e-06 0.000267375321079624 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 9 0 13365 21313 0.000672947510094212 0.000307759154923187 0.00127707788784856 1 0.999826933785262 1 1 0.663732883120057 1 NA NA NA NA NA NA NA NA NA NA 2364 4479 False False 0 0 0 0 0 0 0 Inf 3.14671336895126 Inf 0 0 0.000275972346901473 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA c.-797T>G inhA_c.-797T>G 1 upstream_gene_variant 1673405 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2915 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2377 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA c.-800_-787delATTTCGGCCCGGCC inhA_c.-800_-787delATTTCGGCCCGGCC 1 upstream_gene_variant 1673401 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2936 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-801G>A inhA_c.-801G>A 1 upstream_gene_variant 1673401 1 27 0 27 0 27 20846 27441 0 0 0.00017694296670111 0.999017038007863 0.998570161716172 0.99935212504807 0 0 0.127702867615432 0 0 0.127702867615432 0 0 0.127702867615432 0 0 0.192769550418274 3.26939158002718e-07 28 5574 True False 0 0 0.192769550418274 0 0 0.00017694296670111 0.999017038007863 0.998570161716172 0.99935212504807 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 25 0 25 0 25 13374 21288 0 0 0.000275786657608973 0.998827006991038 0.998268914575298 0.99924076142744 0 0 0.137185171530712 0 0 0.137185171530712 0 0 0.137185171530712 0 0 0.253145616016219 9.21131248854085e-06 26 4479 True False 0 0 0 0 0 0 0 0 0 0.253145616016219 0 0 0.000275786657608973 0.998827006991038 0.998268914575298 0.99924076142744 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-807C>G inhA_c.-807C>G 1 upstream_gene_variant 1673395 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2877 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2351 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-808A>G inhA_c.-808A>G 1 upstream_gene_variant 1673394 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2868 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2341 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-809G>A inhA_c.-809G>A 1 upstream_gene_variant 1673393 1 2 2 0 28 0 20818 27468 0.00134318334452652 0.000892715366584833 0.00194069331308385 1 0.999865711673152 1 1 0.876563881499736 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.247780952409768 Inf 0.185896472182705 375 5574 False False Inf 9.36739739964436 Inf 9.60614793467819e-05 1.16337025251025e-05 0.000346963555365898 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 26 0 13348 21313 0.00194407058471661 0.00127031229682009 0.00284722547593808 1 0.999826933785262 1 1 0.867725395502245 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.299846165954366 Inf 0.148323591761903 196 4479 False False 0 0 0 0 0 0 0 Inf 10.4705082475809 Inf 0.000149812734082397 1.81435320764836e-05 0.000541069218763811 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-809G>C inhA_c.-809G>C 1 upstream_gene_variant 1673393 1 40 2 38 34 38 20812 27430 0.00163100834692506 0.00112977696955073 0.00227843192161994 0.998616572011067 0.998101626446224 0.999020823782757 0.472222222222222 0.353329724056671 0.593470923474326 0.05 0.00611364659935083 0.169196863959417 0.05 0.00611364659935083 0.169196863959417 0.0693678748090676 0.00809533853934851 0.268481733359251 1.30907252280175e-07 26 5574 True False 1.17925387175415 0.719850413121581 1.92477436338018 9.60891707504564e-05 1.16370562046397e-05 0.000347063561133648 0.998616572011067 0.998101626446224 0.999020823782757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 28 2 26 31 26 13343 21287 0.00231793031254673 0.00157544783409477 0.0032885173900642 0.99878008727068 0.998213052481404 0.999202962580054 0.543859649122807 0.406559746004523 0.676445823627575 0.0714285714285714 0.00877049670352713 0.23503477317459 0.0714285714285714 0.00877049670352713 0.23503477317459 0.122720642918499 0.0140842537645883 0.490330031851262 0.00029867194021679 46 4479 True False 0 0 0 0 0 0 0 1.90216996523674 1.09242709982193 3.33685327486596 0.000149868864743349 1.81503301458933e-05 0.000541271902653665 0.99878008727068 0.998213052481404 0.999202962580054 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-813C>T inhA_c.-813C>T 1 upstream_gene_variant 1673389 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-88T>A inhA_c.-88T>A 1 upstream_gene_variant 1674114 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2899 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-93C>T inhA_c.-93C>T 1 upstream_gene_variant 1674109 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2917 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.-94C>T inhA_c.-94C>T 1 upstream_gene_variant 1674108 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA c.99C>A inhA_c.99C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.544526627735454 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid inhA c.9A>C inhA_c.9A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 104 263 20742 27205 0.00498896670824138 0.00407811239997398 0.00604177370329819 0.990425222076598 0.989202012948825 0.991542936197213 0.283378746594005 0.237822718461702 0.332469125998704 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.518651563129566 0.408953951282973 0.653761842680473 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 57 181 13317 21132 0.00426200089726334 0.00322954826143706 0.00551843583144895 0.991507530615117 0.990182714802478 0.992695526212641 0.239495798319327 0.186727371678288 0.298877578954869 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 0 0.499724316984438 0.364066160531709 0.677037172733116 NA NA NA NA NA NA 4 5) Not assoc w R Now listed Silent mutation no 0 +Isoniazid inhA p.Ala114Gly inhA_p.Ala114Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Ala114Thr inhA_p.Ala114Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2903 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2367 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA p.Ala124Val inhA_p.Ala124Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2860 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2335 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Ala133Thr inhA_p.Ala133Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 51.3533466119536 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2348 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Ala190Ser inhA_p.Ala190Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 4 3 20842 27465 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999890782000873 0.99968085216583 0.999977476056514 0.571428571428571 0.184051567640083 0.901011721557492 0 0 0.841886116991581 0 0 0.707598226178713 0 0 7.01707977037795 0.509393260941204 1185 5574 False False 1.75702907590442 0.297192930207644 11.9979296337129 0 0 0.000176976922618654 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 3 3 13371 21310 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999859240838924 0.999588697652472 0.999970971136275 0.5 0.118117248757025 0.881882751242974 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.48685735854804 0.526197549940579 959 4479 False False 0 0 0 0 0 0 0 1.59374766285244 0.213424225946693 11.9045637110481 0 0 0.000275848526268708 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Ala191Thr inhA_p.Ala191Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2939 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Ala201Thr inhA_p.Ala201Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2918 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2379 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Ala213Val inhA_p.Ala213Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Ala22Ser inhA_p.Ala22Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 2908 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 2372 4479 False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 0 0 0.000275827900298067 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Ala235Thr inhA_p.Ala235Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2893 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2363 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Ala235Val inhA_p.Ala235Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Ala239Thr inhA_p.Ala239Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2921 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2380 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Ala239Val inhA_p.Ala239Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 17 0 20829 27468 0.000815504173462534 0.000475130725961031 0.00130538114673077 1 0.999865711673152 1 1 0.804935677030906 1 NA NA NA NA NA NA NA NA NA NA 2940 5574 False False Inf 5.44096997305453 Inf 0 0 0.000177087369412526 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 10 0 13364 21313 0.000747719455660236 0.000358616922835118 0.00137465137870696 1 0.999826933785262 1 1 0.691502892181239 1 NA NA NA NA NA NA NA NA NA NA 2392 4479 False False 0 0 0 0 0 0 0 Inf 3.57391601991246 Inf 0 0 0.000275992994481552 1 0.999826933785262 1 5 3) Uncertain significance No change no 1 +Isoniazid inhA p.Ala252Thr inhA_p.Ala252Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2934 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2389 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA p.Ala252Val inhA_p.Ala252Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 2 2 2 2 20844 27466 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999927188000582 0.999737003036386 0.999991182007438 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 1.3176933410094 0.0955278435529395 18.1762534351792 1 2027.5 5574 False False 1.3176933410094 0.0955278435529395 18.1762534351792 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 2 2 2 2 13372 21311 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999906160559283 0.999661061221376 0.999988635406343 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 1.59370326054442 0.115491055908661 21.9865025501046 0.642231504025548 993 4479 False False 0 0 0 0 0 0 0 1.59370326054442 0.115491055908661 21.9865025501046 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Ala26Thr inhA_p.Ala26Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2898 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2365 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA p.Ala58Val inhA_p.Ala58Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Arg27Trp inhA_p.Arg27Trp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2906 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2370 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA p.Asn139Ser inhA_p.Asn139Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Asn139Tyr inhA_p.Asn139Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA p.Asn231Asp inhA_p.Asn231Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2869 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2342 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA p.Asn231Lys inhA_p.Asn231Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Asp248Asn inhA_p.Asp248Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA p.Asp42Ala inhA_p.Asp42Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA p.Asp52Gly inhA_p.Asp52Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2900 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Asp89Asn inhA_p.Asp89Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Isoniazid inhA p.Gln100His inhA_p.Gln100His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Gln214Arg inhA_p.Gln214Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Gln216Arg inhA_p.Gln216Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA p.Gln35Arg inhA_p.Gln35Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 17 1 16 3 16 20843 27452 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.99941750400466 0.999054234895718 0.999667017718464 0.157894736842105 0.0338262490017646 0.395784551266674 0.0588235294117647 0.00148817439126663 0.28688939666722 0.0588235294117647 0.00148817439126663 0.28688939666722 0.082317804538694 0.0019671718395971 0.529997765117038 0.00110177912570309 77 5574 False False 0.246953413616082 0.0461103487057789 0.862924537884952 4.79754365764728e-05 1.21463215353938e-06 0.000267272712750976 0.99941750400466 0.999054234895718 0.999667017718464 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 1 8 3 8 13371 21305 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999624642237132 0.999260530264256 0.999837933676441 0.272727272727272 0.0602177341729066 0.609742559572421 0.111111111111111 0.00280913674659921 0.482496514917337 0.111111111111111 0.00280913674659921 0.482496514917337 0.199171714905392 0.00449243397601649 1.48593520105351 0.167039176037349 273 4479 False False 0 0 0 0 0 0 0 0.597515144716176 0.102061600869156 2.49011680409225 7.47831289261142e-05 1.89334310623943e-06 0.000416593707936992 0.999624642237132 0.999260530264256 0.999837933676441 NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Glu209Gly inhA_p.Glu209Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2894 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Glu219Ala inhA_p.Glu219Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA p.Glu31Lys inhA_p.Glu31Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Glu80Ala inhA_p.Glu80Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Gly141Arg inhA_p.Gly141Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Gly142Ser inhA_p.Gly142Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Gly183Arg inhA_p.Gly183Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 1.99604811372315 0.139118032244638 322.5 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.41420404242617 0.305473156458586 444 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Gly183Asp inhA_p.Gly183Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 1.99604811372315 0.139118032244638 322.5 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.41420404242617 0.305473156458586 444 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Gly183Ser inhA_p.Gly183Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 51.3533466119536 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 62.1009148060541 1 1642.5 4479 False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 0 0 0.000275827900298067 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA p.Gly212Ser inhA_p.Gly212Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Gly221Ser inhA_p.Gly221Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Isoniazid inhA p.Gly33Asp inhA_p.Gly33Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Gly33Ser inhA_p.Gly33Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2891 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2360 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Gly40Trp inhA_p.Gly40Trp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2941 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2393 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Gly76Asp inhA_p.Gly76Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2922 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2381 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Gly76Ser inhA_p.Gly76Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2911 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA p.Gly83Arg inhA_p.Gly83Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 1 6 20845 27462 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999781564001747 0.999524617886493 0.999919833755107 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.521823750104981 0 0 0.4592581264399 0 0 1.43786917636023 0.0743390630358733 263 5574 False False 0.219573039098105 0.00477770915407814 1.81014820057657 0 0 0.000176951454458875 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 1 5 13373 21308 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999765401398207 0.999452610763328 0.999923822225278 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.73907646387712 0.163960168380046 259.5 4479 False False 0 0 0 0 0 0 0 0.318671950945935 0.00674139558547252 2.84834809554519 0 0 0.000275807277411719 0.999765401398207 0.999452610763328 0.999923822225278 NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.His24Gln inhA_p.His24Gln 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2929 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2387 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.His70Asp inhA_p.His70Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Ile15Leu inhA_p.Ile15Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2875 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2349 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Ile16Thr inhA_p.Ile16Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 51.3533466119536 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Ile16Val inhA_p.Ile16Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2916 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2378 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Ile194Thr inhA_p.Ile194Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 5 0 240 4 20606 27464 0.0115130000959416 0.0101092919284915 0.0130552969225133 0.999854376001165 0.999627187086024 0.999960320981843 0.983606557377049 0.95856052722558 0.995515736090787 1 0.478176249895018 1 0.555555555555555 0.212008506778868 0.863004337734833 Inf 1.22120119693578 Inf 0.0144803302293718 145 5574 False False 79.9689410851208 30.833549305535 294.231342794101 0.000242588908835088 7.87724999318055e-05 0.000566030014869143 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 4 0 169 3 13205 21310 0.0126364588006579 0.0108126184575267 0.0146766836859525 0.999859240838924 0.999588697652472 0.999970971136275 0.982558139534883 0.949875837113382 0.996388523869583 1 0.397635364383525 1 0.571428571428571 0.184051567640083 0.901011721557492 Inf 1.06509399093803 Inf 0.0214350814465395 110 4479 False False 0 0 0 0 0 0 0 90.909756405402 30.5815410267781 444.725048330892 0.000302823832235596 8.25152687864226e-05 0.000775166113046812 0.999859240838924 0.999588697652472 0.999970971136275 124 3) Uncertain significance No change no 1 +Isoniazid inhA p.Ile21Met inhA_p.Ile21Met 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2888 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2358 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Ile21Thr inhA_p.Ile21Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 164 3 20682 27465 0.0078672167322268 0.00671295080775048 0.00916171497565188 0.999890782000873 0.99968085216583 0.999977476056514 0.982035928143712 0.948401077873817 0.996279944059613 1 0.025 1 0.25 0.00630946320970987 0.805879550316756 Inf 0.0340485052540027 Inf 0.429571321757913 588 5574 False False 72.5954936659897 24.4020844378012 353.858771270778 4.83488855581878e-05 1.22408705162144e-06 0.000269352979210767 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 72 1 13302 21312 0.0053835800807537 0.00421463329049101 0.0067749914288816 0.999953080279641 0.999738608085756 0.999998812096234 0.986301369863013 0.926023676821656 0.9996532408474 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0410778493860797 Inf 0.3843131590351 470 4479 False False 0 0 0 0 0 0 0 115.355886332882 20.03967979154 4499.49789458753 7.51710140569796e-05 1.90316348886103e-06 0.000418754124895364 0.999953080279641 0.999738608085756 0.999998812096234 16 3) Uncertain significance No change no 1 +Isoniazid inhA p.Ile21Val inhA_p.Ile21Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 13 3 10 53 13 20793 27455 0.00254245418785378 0.00190503496348425 0.00332429002181123 0.999526722003786 0.99919081619501 0.999747976101462 0.803030303030303 0.686761154151906 0.890739734382282 0.23076923076923 0.0503810734911515 0.53813153923404 0.1875 0.0404737339059459 0.456456546231611 0.396118886163612 0.0700423996024071 1.53870268495287 0.170741702183339 371 5574 False False 5.38315409401832 2.89403339945192 10.7703604291745 0.000144258511252163 2.97505612156375e-05 0.000421526132267116 0.999526722003786 0.99919081619501 0.999747976101462 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 12 3 9 37 12 13337 21301 0.00276656198594287 0.00194864015550479 0.00381134478706768 0.999436963355698 0.999016695060306 0.999709037985722 0.755102040816326 0.611304085311566 0.866571289157706 0.25 0.0548606445279927 0.571858461878189 0.2 0.0433120051058366 0.480891133806853 0.532378595886131 0.0926900438016404 2.1338081829847 0.391627443696329 669 4479 False False 0 0 0 0 0 0 0 4.92450201194671 2.51061741821145 10.3733899980737 0.000224887556221889 4.63796219531726e-05 0.00065707481814275 0.999436963355698 0.999016695060306 0.999709037985722 6 3) Uncertain significance No change no 1 +Isoniazid inhA p.Ile228Val inhA_p.Ile228Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 36 1 35 6 35 20840 27433 0.000287825002398541 0.000105633792978048 0.000626367784710498 0.998725790010193 0.998228323594761 0.999112310547048 0.146341463414634 0.0556573637124366 0.291730488017494 0.0277777777777777 0.00070302520590478 0.145289264746853 0.0277777777777777 0.00070302520590478 0.145289264746853 0.0376103646833013 0.000930509704346818 0.22380267625763 5.56440742938697e-08 24 5574 True False 0.225662188099808 0.0775678649306911 0.542363304437111 4.79823424979607e-05 1.21480699612118e-06 0.000267311181643879 0.998725790010193 0.998228323594761 0.999112310547048 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 31 1 30 5 30 13369 21283 0.000373859727830118 0.000121402023062639 0.000872246401868143 0.998592408389246 0.997991180201286 0.999050108601822 0.142857142857142 0.0480607784036389 0.302571351690951 0.032258064516129 0.000816370071846613 0.167021116230227 0.032258064516129 0.000816370071846613 0.167021116230227 0.0530655496546737 0.00130490846156705 0.319300410216395 7.68950481597176e-06 25 4479 True False 0 0 0 0 0 0 0 0.265327748273368 0.0803308952630827 0.690911117956232 7.47943156320119e-05 1.89362632857505e-06 0.000416656014965588 0.998592408389246 0.997991180201286 0.999050108601822 2 3) Uncertain significance No change no 1 +Isoniazid inhA p.Ile50Val inhA_p.Ile50Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2892 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2361 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Ile95Leu inhA_p.Ile95Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2901 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Isoniazid inhA p.Ile95Val inhA_p.Ile95Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 1 0.025 1 1 0.025 1 Inf 0.0337891992100405 Inf 0.431445603576751 617.5 5574 False False Inf 0.544526627735454 Inf 4.79754365764728e-05 1.21463215353938e-06 0.000267272712750976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.040864745349235 Inf 0.385544600126852 512 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 7.47775368279368e-05 1.89320152683959e-06 0.000416562561410248 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Leu268Phe inhA_p.Leu268Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Leu61Val inhA_p.Leu61Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2925 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Lys118Glu inhA_p.Lys118Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Lys233Thr inhA_p.Lys233Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2883 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2355 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA p.Met103Val inhA_p.Met103Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.31767810026385 0.0167927522337569 103.35711725526 1 1253.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.59365886487699 0.0203005577541163 124.983813232444 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Met130Val inhA_p.Met130Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2884 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2356 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA p.Met155Ile inhA_p.Met155Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Met155Leu inhA_p.Met155Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2912 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2375 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA p.Phe41Ser inhA_p.Phe41Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2919 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Isoniazid inhA p.Pro107Ser inhA_p.Pro107Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2930 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Pro140Leu inhA_p.Pro140Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA p.Pro55Leu inhA_p.Pro55Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA p.Ser143Cys inhA_p.Ser143Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Ser19Ala inhA_p.Ser19Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Ser19Leu inhA_p.Ser19Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Ser94Ala inhA_p.Ser94Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 48 28 20 213 27 20633 27441 0.0102177875851482 0.00889727984918739 0.0116774294202073 0.999017038007863 0.998570161716172 0.99935212504807 0.8875 0.840550857927552 0.924539400703161 0.583333333333333 0.432131711340739 0.723872576135536 0.509090909090909 0.370705345105322 0.646463796842059 1.86193961130228 1.01172413460911 3.48722102290738 0.0401131588473724 179 5574 False False 10.4918819367033 7.00633488271357 16.2987858240311 0.00135521029959827 0.000900710425776011 0.00195806516718642 0.999017038007863 0.998570161716172 0.99935212504807 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 33 19 14 127 18 13247 21295 0.009496037086885 0.00792239232848448 0.0112882825841944 0.999155445033547 0.998665566208554 0.999499388823668 0.875862068965517 0.810919084604511 0.924740843759471 0.575757575757575 0.392153016187885 0.745238177265304 0.513513513513513 0.343996815665766 0.680785893518459 2.18165298881687 1.03667610613295 4.70465570928399 0.030438363508306 125 4479 False False 0 0 0 0 0 0 0 11.3420439009251 6.88925969484679 19.7571815000794 0.00143223277551635 0.000862511032144831 0.00223570929450522 0.999155445033547 0.998665566208554 0.999499388823668 31 INH-ETO cross-resistance 2) Assoc w R - Interim Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance) UP from Uncertain to AwRI yes INH-ETH X-R F 4 +Isoniazid inhA p.Thr162Ser inhA_p.Thr162Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 24 0 20822 27468 0.00115130000959416 0.000737794566721317 0.00171256196858956 1 0.999865711673152 1 1 0.857526402277474 1 NA NA NA NA NA NA NA NA NA NA 2904 5574 False False Inf 7.94033420262242 Inf 0 0 0.000177146897881585 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2368 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 32 3) Uncertain significance No change no 1 +Isoniazid inhA p.Thr236Met inhA_p.Thr236Met 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 10 0 20836 27468 0.000479708337330902 0.000230061997553563 0.000882023176671562 1 0.999865711673152 1 1 0.691502892181239 1 NA NA NA NA NA NA NA NA NA NA 2923 5574 False False Inf 2.95450432812812 Inf 0 0 0.000177027880937939 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 9 0 13365 21313 0.000672947510094212 0.000307759154923187 0.00127707788784856 1 0.999826933785262 1 1 0.663732883120057 1 NA NA NA NA NA NA NA NA NA NA 2382 4479 False False 0 0 0 0 0 0 0 Inf 3.14671336895126 Inf 0 0 0.000275972346901473 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Thr266Ala inhA_p.Thr266Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Thr2Ala inhA_p.Thr2Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Thr2Pro inhA_p.Thr2Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2902 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2366 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Tyr182His inhA_p.Tyr182His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Val12Ile inhA_p.Val12Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid inhA p.Val171Ile inhA_p.Val171Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Isoniazid inhA p.Val189Ile inhA_p.Val189Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Val203Ala inhA_p.Val203Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Val28Leu inhA_p.Val28Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2861 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2336 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Val65Ala inhA_p.Val65Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2870 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2343 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Val78Ala inhA_p.Val78Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 8 62 20838 27406 0.000383766669864722 0.000165697303700768 0.000756032532322191 0.997742828018057 0.997107328463502 0.998269014702526 0.114285714285714 0.0506521987903564 0.21282804216909 NA NA NA 0 0 0.0577626344292909 NA NA NA NA NA NA False True 0.16970237376505 0.0701777444603646 0.355709532830646 0 0 0.000177010891571197 0.997742828018057 0.997107328463502 0.998269014702526 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 6 55 13368 21258 0.000448631673396141 0.000164657143425453 0.000976224581517196 0.997419415380284 0.996642322195326 0.998055376884694 0.0983606557377049 0.0369599948778518 0.20189619185437 NA NA NA 0 0 0.0648707608254246 NA NA NA NA NA NA False True 0 1 1 0 0 1 1 0.173478047984331 0.0610203326452612 0.402444961125462 0 0 0.00027591042269331 0.997419415380284 0.996642322195326 0.998055376884694 3 Not assoc w RI 5) Not assoc w R UP from NotAwRI to NotAwR yes 4 +Isoniazid inhA p.Val91Ala inhA_p.Val91Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid inhA p.Val92Met inhA_p.Val92Met 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2931 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.1008G>T katG_c.1008G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-100G>A katG_c.-100G>A 1 upstream_gene_variant 2156211 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.1014C>G katG_c.1014C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1014C>T katG_c.1014C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 4 20845 27464 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999854376001165 0.999627187086024 0.999960320981843 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.329383545214679 0.00669260119676484 3.32889360843958 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1029G>A katG_c.1029G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-102A>G katG_c.-102A>G 1 upstream_gene_variant 2156213 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3421 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG c.1032G>A katG_c.1032G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 8 20844 27460 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.99970875200233 0.999426206431739 0.999874251669172 0.2 0.0252107263268333 0.556095462307641 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.329351372097486 0.0340635477373695 1.6506834450398 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 5 13373 21308 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999765401398207 0.999452610763328 0.999923822225278 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.318671950945935 0.00674139558547252 2.84834809554519 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1035G>A katG_c.1035G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1047C>A katG_c.1047C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.439194051331254 0.00837049629364692 5.4704842261679 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.85651838973546 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.105C>T katG_c.105C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 3 21 20843 27447 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999235474006116 0.998831576963824 0.999526686034611 0.125 0.0265593149862489 0.323611358188833 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.188120711989636 0.0359255331223503 0.630172266058811 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 3 19 13371 21294 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999108525313189 0.998608200368116 0.999463191365845 0.136363636363636 0.0290558511287467 0.349122097257408 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.251455427889895 0.0476541606489635 0.854489590836258 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1062C>T katG_c.1062C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1080T>C katG_c.1080T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1080T>G katG_c.1080T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-108A>T katG_c.-108A>T 1 upstream_gene_variant 2156219 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.108G>A katG_c.108G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1095G>A katG_c.1095G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 38 0 20808 27468 0.00182289168185743 0.00129029962509865 0.00250121141611544 1 0.999865711673152 1 1 0.907487238584121 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 12.9458416325061 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 18 0 13356 21313 0.00134589502018842 0.000797851614369596 0.00212626349435784 1 0.999826933785262 1 1 0.814698031862147 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 7.01399263973017 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-109G>A katG_c.-109G>A 1 upstream_gene_variant 2156220 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-10A>C katG_c.-10A>C 1 upstream_gene_variant 2156121 1 2 2 0 10 1 20836 27467 0.000479708337330902 0.000230061997553563 0.000882023176671562 0.999963594000291 0.999797175631493 0.999999078280314 0.909090909090909 0.587220083011617 0.997701027786185 1 0.158113883008419 1 0.666666666666666 0.0942993240502461 0.991596241340387 Inf 0.247557897462432 Inf 0.186087003784025 376 5574 False False 13.1824726435016 1.87489573468025 570.603433894195 9.59785008158172e-05 1.16236530744227e-05 0.000346663883561861 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 1 13370 21312 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 0.999953080279641 0.999738608085756 0.999998812096234 0.8 0.28358206388191 0.994949236620532 NA NA NA 0 0 0.975 NA NA NA NA 2696 4479 False False 0 0 0 0 0 0 0 6.37606581899775 0.630846560224411 313.513380938872 0 0 0.000275869155324334 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG c.-10A>G katG_c.-10A>G 1 upstream_gene_variant 2156121 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3003 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2444 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.1101G>A katG_c.1101G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.99604811372315 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.41420404242617 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1107C>A katG_c.1107C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1107C>T katG_c.1107C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1116G>A katG_c.1116G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1119C>T katG_c.1119C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-111A>G katG_c.-111A>G 1 upstream_gene_variant 2156222 1 3 0 3 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18880616510555 0.264079043314886 541.5 5574 False False 0.439194051331254 0.00837049629364692 5.4704842261679 0 0 0.000176951454458875 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48598624162872 0.526186417038858 925 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.1125G>T katG_c.1125G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1128G>A katG_c.1128G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-112G>A katG_c.-112G>A 1 upstream_gene_variant 2156223 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3487 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2811 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.1132C>T katG_c.1132C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 4 9 20842 27459 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999672346002621 0.99937810218515 0.999850165132458 0.307692307692307 0.0909203945720966 0.614261661750705 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.585548411860666 0.13173108052869 2.09838247392389 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 3 7 13371 21306 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.99967156195749 0.999323409938814 0.999867941002665 0.3 0.0667395111777345 0.652452850059997 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.682906503413571 0.113956481543253 2.99204017959139 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1137C>T katG_c.1137C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1140T>G katG_c.1140T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1143C>T katG_c.1143C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1155G>A katG_c.1155G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-116G>C katG_c.-116G>C 1 upstream_gene_variant 2156227 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3358 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2716 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.1170T>C katG_c.1170T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1173G>A katG_c.1173G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-118_-78delCTGTTGGACGAGGCGGAGGTCATCTACTGGGGTCTATGTCC katG_c.-118_-78delCTGTTGGACGAGGCGGAGGTCATCTACTGGGGTCTATGTCC 1 upstream_gene_variant 2156188 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3256 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2635 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.1185T>G katG_c.1185T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1192C>T katG_c.1192C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1197A>G katG_c.1197A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 16 39 20830 27429 0.000767533339729444 0.000438773245501675 0.00124612759964746 0.998580166011358 0.998059546022616 0.998990170448098 0.29090909090909 0.176299657358236 0.428982582556114 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.540226743971343 0.281760811963955 0.989595881614081 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 14 34 13360 21279 0.00104680723792433 0.000572413688832994 0.00175574154681136 0.998404729507812 0.997771476125476 0.998894983644582 0.291666666666666 0.169530798628028 0.44063477991369 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 0 1 0 0 0 1 0.655833920394505 0.325013390340652 1.25523732818116 NA NA NA NA NA NA 8 Literature evidence (PMID 32143680) 4) Not assoc w R - Interim Now listed Silent mutation no Lit. (PMID 32143680) 0 +Isoniazid katG c.-11G>C katG_c.-11G>C 1 upstream_gene_variant 2156122 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3239 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2623 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.1200C>T katG_c.1200C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-120T>C katG_c.-120T>C 1 upstream_gene_variant 2156231 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3451 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2786 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.1210T>C katG_c.1210T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1212G>A katG_c.1212G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.99604811372315 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.41420404242617 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1218C>T katG_c.1218C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-121T>C katG_c.-121T>C 1 upstream_gene_variant 2156232 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3152 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.1224C>T katG_c.1224C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1227C>T katG_c.1227C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1233C>G katG_c.1233C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 3 7 20843 27461 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999745158002038 0.999474999027776 0.999897534357495 0.3 0.0667395111777345 0.652452850059997 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.564650002398887 0.0941990699429094 2.47377675968382 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 3 7 13371 21306 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.99967156195749 0.999323409938814 0.999867941002665 0.3 0.0667395111777345 0.652452850059997 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.682906503413571 0.113956481543253 2.99204017959139 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.123C>T katG_c.123C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.18865318395302 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.85651838973546 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-124G>A katG_c.-124G>A 1 upstream_gene_variant 2156235 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.1257C>T katG_c.1257C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1263T>C katG_c.1263T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1266C>T katG_c.1266C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-126A>C katG_c.-126A>C 1 upstream_gene_variant 2156237 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3488 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2812 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.1272G>C katG_c.1272G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1278C>T katG_c.1278C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1284G>A katG_c.1284G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1284G>C katG_c.1284G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1284G>T katG_c.1284G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 5 20845 27463 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999817970001456 0.999575254267103 0.999940892797913 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.263497241544735 0.00557522895465965 2.35509564487831 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 5 13373 21308 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999765401398207 0.999452610763328 0.999923822225278 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.318671950945935 0.00674139558547252 2.84834809554519 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-128T>C katG_c.-128T>C 1 upstream_gene_variant 2156239 2 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-128T>G katG_c.-128T>G 1 upstream_gene_variant 2156239 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-129_-125delATAAC katG_c.-129_-125delATAAC 1 upstream_gene_variant 2156235 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3504 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2819 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.1296C>A katG_c.1296C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.99604811372315 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1299G>A katG_c.1299G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.129C>T katG_c.129C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.12A>G katG_c.12A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 13 0 20833 27468 0.000623620838530173 0.000332092285535748 0.00106617452923529 1 0.999865711673152 1 1 0.752947361999529 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 4.01743988819503 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 13 0 13361 21313 0.000972035292358307 0.000517666151348512 0.00166163634851859 1 0.999826933785262 1 1 0.752947361999529 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 4.85999660216436 Inf NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1309C>T katG_c.1309C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1317G>A katG_c.1317G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-131C>G katG_c.-131C>G 1 upstream_gene_variant 2156242 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.1326C>T katG_c.1326C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1329T>G katG_c.1329T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-132A>G katG_c.-132A>G 1 upstream_gene_variant 2156243 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.1356A>G katG_c.1356A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1359C>T katG_c.1359C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.135G>A katG_c.135G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1389G>T katG_c.1389G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.138G>A katG_c.138G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1395G>C katG_c.1395G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-13T>C katG_c.-13T>C 1 upstream_gene_variant 2156124 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.1416A>G katG_c.1416A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 20 0 20826 27468 0.000959416674661805 0.000586132014909014 0.00148135424594851 1 0.999865711673152 1 1 0.831566529016914 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 6.51017121398754 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 14 0 13360 21313 0.00104680723792433 0.000572413688832994 0.00175574154681136 1 0.999826933785262 1 1 0.768364238349883 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 5.29062751649696 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1419T>G katG_c.1419T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.141A>C katG_c.141A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.99604811372315 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.85651838973546 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.141A>G katG_c.141A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 6 20844 27462 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999781564001747 0.999524617886493 0.999919833755107 0.25 0.0318540262499442 0.650855794412824 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.439167146421032 0.0433460282809438 2.45619176778693 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 6 13373 21307 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999718481677849 0.999387354605726 0.999896680954833 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.265547496198808 0.00577686092206708 2.18912593855065 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-141C>A katG_c.-141C>A 1 upstream_gene_variant 2156252 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-141C>T katG_c.-141C>T 1 upstream_gene_variant 2156252 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.1434G>A katG_c.1434G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1434G>C katG_c.1434G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 72 3 20774 27465 0.0034539000287825 0.00270341567055964 0.00434766641670911 0.999890782000873 0.99968085216583 0.999977476056514 0.96 0.88752317823999 0.99167383433392 NA NA NA NA NA NA NA NA NA NA NA NA False False 31.7300471743525 10.4272944909728 157.70472414615 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 25 2 13349 21311 0.00186929863915059 0.00121006548869323 0.00275822519578355 0.999906160559283 0.999661061221376 0.999988635406343 0.925925925925926 0.757101653154372 0.990899927057693 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 19.9556146527829 4.97431729497115 173.578167878985 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1446G>A katG_c.1446G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.144G>A katG_c.144G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 6 20846 27462 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.11900921779861 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 5 13374 21308 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.73894646374006 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-145C>G katG_c.-145C>G 1 upstream_gene_variant 2156256 0 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3153 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2556 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.1461C>T katG_c.1461C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-146T>C katG_c.-146T>C 1 upstream_gene_variant 2156257 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG c.1473C>T katG_c.1473C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1482T>C katG_c.1482T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1495C>T katG_c.1495C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1497G>A katG_c.1497G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.544526627735454 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-14C>G katG_c.-14C>G 1 upstream_gene_variant 2156125 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3079 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2501 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-150C>A katG_c.-150C>A 1 upstream_gene_variant 2156261 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2984 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.1518G>A katG_c.1518G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-152A>C katG_c.-152A>C 1 upstream_gene_variant 2156263 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-152A>G katG_c.-152A>G 1 upstream_gene_variant 2156263 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG c.1530C>A katG_c.1530C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1530C>G katG_c.1530C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-153C>A katG_c.-153C>A 1 upstream_gene_variant 2156264 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3376 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2730 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.1542G>C katG_c.1542G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1563G>C katG_c.1563G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 3 9 20843 27459 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999672346002621 0.99937810218515 0.999850165132458 0.25 0.0548606445279927 0.571858461878189 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.439140238929136 0.0764596530706342 1.75996892947283 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 8 13373 21305 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999624642237132 0.999260530264256 0.999837933676441 0.111111111111111 0.00280913674659921 0.482496514917337 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.199141927764899 0.00449176289276445 1.48571302597227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1566A>G katG_c.1566A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-156A>C katG_c.-156A>C 1 upstream_gene_variant 2156267 1 5 0 5 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.43785249906968 0.0743380732312645 251 5574 False False 0 0 1.43785249906968 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 13374 21308 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.73894646374006 0.163960020972012 248.5 4479 False False 0 0 0 0 0 0 0 0 0 1.73894646374006 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.156G>T katG_c.156G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1572C>T katG_c.1572C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1581A>G katG_c.1581A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1587C>T katG_c.1587C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1593G>A katG_c.1593G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.159C>G katG_c.159C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1617C>T katG_c.1617C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.162C>A katG_c.162C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.162C>T katG_c.162C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1632C>T katG_c.1632C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 7 20844 27461 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999745158002038 0.999474999027776 0.999897534357495 0.222222222222222 0.0281449734778982 0.600093573716312 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.376415275379005 0.0381509889597215 1.97729867984898 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 5 13373 21308 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999765401398207 0.999452610763328 0.999923822225278 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.318671950945935 0.00674139558547252 2.84834809554519 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1635G>T katG_c.1635G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-163G>A katG_c.-163G>A 1 upstream_gene_variant 2156274 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3240 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2624 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.1653C>T katG_c.1653C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 82 11 20764 27457 0.0039336083661134 0.0031297013040727 0.00488032678942694 0.999599534003203 0.9992835689522 0.999800072407065 0.881720430107526 0.798213567429886 0.939452160067355 NA NA NA NA NA NA NA NA NA NA NA NA False False 9.85741930964431 5.22818288717311 20.5210611835496 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 21 10 13353 21303 0.00157021085688649 0.000972239812025402 0.00239923787401666 0.999530802796415 0.99913729947772 0.999774979505452 0.677419354838709 0.48627017040725 0.83317636257704 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.35028083576724 1.5094822118316 7.9703475857992 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1665A>G katG_c.1665A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1668A>C katG_c.1668A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1683C>T katG_c.1683C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.247471899512553 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-168G>A katG_c.-168G>A 1 upstream_gene_variant 2156279 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.1692G>A katG_c.1692G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1695G>T katG_c.1695G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-16T>C katG_c.-16T>C 1 upstream_gene_variant 2156127 0 0 0 0 5 1 20841 27467 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.999963594000291 0.999797175631493 0.999999078280314 0.833333333333333 0.358765421002325 0.99578925548551 NA NA NA 0 0 0.975 NA NA NA NA 3286 5574 False False 6.58965500695744 0.737267067818355 311.215258952954 0 0 0.000176985413634466 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 2656 4479 False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 0 0 0.000275827900298067 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.1704C>T katG_c.1704C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.247471899512553 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-171A>G katG_c.-171A>G 1 upstream_gene_variant 2156282 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-172G>A katG_c.-172G>A 1 upstream_gene_variant 2156283 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-173C>A katG_c.-173C>A 1 upstream_gene_variant 2156284 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3359 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.1740C>T katG_c.1740C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1743G>T katG_c.1743G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 2 20844 27466 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999927188000582 0.999737003036386 0.999991182007438 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.3176933410094 0.0955278435529395 18.1762534351792 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1758G>A katG_c.1758G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.18865318395302 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1759C>T katG_c.1759C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1761G>A katG_c.1761G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1767C>A katG_c.1767C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 4 20845 27464 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999854376001165 0.999627187086024 0.999960320981843 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.329383545214679 0.00669260119676484 3.32889360843958 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.85651838973546 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1767C>T katG_c.1767C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 4 20845 27464 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999854376001165 0.999627187086024 0.999960320981843 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.329383545214679 0.00669260119676484 3.32889360843958 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 4 13373 21309 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999812321118566 0.999519537882235 0.999948861529775 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.398358633066626 0.00809276091420046 4.02622197901862 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1770G>A katG_c.1770G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1776T>C katG_c.1776T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.43785249906968 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 5 13374 21308 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.73894646374006 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-17C>T katG_c.-17C>T 1 upstream_gene_variant 2156128 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3046 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2477 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-18_-17insG katG_c.-18_-17insG 1 upstream_gene_variant 2156128 0 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2942 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2394 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.1803C>T katG_c.1803C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1809G>A katG_c.1809G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-180C>G katG_c.-180C>G 1 upstream_gene_variant 2156291 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3452 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-180C>T katG_c.-180C>T 1 upstream_gene_variant 2156291 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3332 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2697 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.1815G>A katG_c.1815G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1833C>T katG_c.1833C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 7 4 20839 27464 0.000335795836131632 0.000135017659185429 0.000691744589626827 0.999854376001165 0.999627187086024 0.999960320981843 0.636363636363636 0.307904715011677 0.890736556180901 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.3063486731609 0.586218839161606 10.7462831837393 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 6 2 13368 21311 0.000448631673396141 0.000164657143425453 0.000976224581517196 0.999906160559283 0.999661061221376 0.999988635406343 0.75 0.349144205587175 0.968145973750055 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.78254039497307 0.854982288254785 48.451322625226 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1836C>T katG_c.1836C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.183G>A katG_c.183G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-183T>G katG_c.-183T>G 1 upstream_gene_variant 2156294 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3004 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2445 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.1848G>A katG_c.1848G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 7 0 20839 27468 0.000335795836131632 0.000135017659185429 0.000691744589626827 1 0.999865711673152 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.89951899263229 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1848G>C katG_c.1848G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-185T>C katG_c.-185T>C 1 upstream_gene_variant 2156296 1 2 2 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.24749564543886 Inf 0.186140231321028 382.5 5574 False False Inf 0.869878292971449 Inf 9.59508731529456e-05 1.16203071146137e-05 0.000346564107961184 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.040864745349235 Inf 0.385544600126852 512 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 7.47775368279368e-05 1.89320152683959e-06 0.000416562561410248 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain AwRI by relaxed thresholds (not endorsed) yes O 0 +Isoniazid katG c.1869G>A katG_c.1869G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-186T>C katG_c.-186T>C 1 upstream_gene_variant 2156297 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.1875G>A katG_c.1875G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1878G>T katG_c.1878G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-187delG katG_c.-187delG 1 upstream_gene_variant 2156297 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-187G>A katG_c.-187G>A 1 upstream_gene_variant 2156298 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3109 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2525 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-187G>T katG_c.-187G>T 1 upstream_gene_variant 2156298 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-18A>G katG_c.-18A>G 1 upstream_gene_variant 2156129 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3505 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2820 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.1921T>C katG_c.1921T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1923A>G katG_c.1923A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.192T>C katG_c.192T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.247471899512553 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1941C>T katG_c.1941C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1944G>A katG_c.1944G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1950C>A katG_c.1950C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1959G>A katG_c.1959G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.195C>A katG_c.195C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1962C>G katG_c.1962C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.247471899512553 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1968C>T katG_c.1968C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.1977G>A katG_c.1977G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.247471899512553 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-197G>A katG_c.-197G>A 1 upstream_gene_variant 2156308 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG c.1980C>T katG_c.1980C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-198G>C katG_c.-198G>C 1 upstream_gene_variant 2156309 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3422 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2769 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.1G>A katG_c.1G>A 1 initiator_codon_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-1T>C katG_c.-1T>C 1 upstream_gene_variant 2156112 1 5 0 5 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.43785249906968 0.0743380732312645 251 5574 False False 0 0 1.43785249906968 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.41420404242617 0.305473156458586 444 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 1 3) Uncertain significance No change no 1 +Isoniazid katG c.-1T>G katG_c.-1T>G 1 upstream_gene_variant 2156112 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2985 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-2_-1insAATGC katG_c.-2_-1insAATGC 1 upstream_gene_variant 2156112 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3425 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG c.2019A>G katG_c.2019A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-201G>A katG_c.-201G>A 1 upstream_gene_variant 2156312 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3154 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2557 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.2025C>T katG_c.2025C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.2028G>T katG_c.2028G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-202T>C katG_c.-202T>C 1 upstream_gene_variant 2156313 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3110 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2526 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.2037G>A katG_c.2037G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.2049C>G katG_c.2049C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-204T>G katG_c.-204T>G 1 upstream_gene_variant 2156315 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3333 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-205G>T katG_c.-205G>T 1 upstream_gene_variant 2156316 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3257 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-206C>A katG_c.-206C>A 1 upstream_gene_variant 2156317 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.207G>T katG_c.207G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-207T>C katG_c.-207T>C 1 upstream_gene_variant 2156318 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG c.2086C>T katG_c.2086C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-208A>G katG_c.-208A>G 1 upstream_gene_variant 2156319 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-209C>T katG_c.-209C>T 1 upstream_gene_variant 2156320 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-20C>T katG_c.-20C>T 1 upstream_gene_variant 2156131 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3080 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2502 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-210A>C katG_c.-210A>C 1 upstream_gene_variant 2156321 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3391 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2742 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.2110T>C katG_c.2110T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.18865318395302 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-212T>C katG_c.-212T>C 1 upstream_gene_variant 2156323 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.2148G>A katG_c.2148G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.2151G>A katG_c.2151G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.2157G>A katG_c.2157G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-215C>G katG_c.-215C>G 1 upstream_gene_variant 2156326 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2943 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2395 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.2166G>A katG_c.2166G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.216C>T katG_c.216C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.2187C>T katG_c.2187C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.18865318395302 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-21C>A katG_c.-21C>A 1 upstream_gene_variant 2156132 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance No change no 1 +Isoniazid katG c.-21C>G katG_c.-21C>G 1 upstream_gene_variant 2156132 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-21C>T katG_c.-21C>T 1 upstream_gene_variant 2156132 1 7 0 7 0 7 20846 27461 0 0 0.00017694296670111 0.999745158002038 0.999474999027776 0.999897534357495 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.914121240039481 0.0219749245408003 156 5574 False False 0 0 0.914121240039481 0 0 0.00017694296670111 0.999745158002038 0.999474999027776 0.999897534357495 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 7 13374 21306 0 0 0.000275786657608973 0.99967156195749 0.999323409938814 0.999867941002665 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 1.10552510564584 0.0484388314759391 130.5 4479 False False 0 0 0 0 0 0 0 0 0 1.10552510564584 0 0 0.000275786657608973 0.99967156195749 0.999323409938814 0.999867941002665 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.2202C>G katG_c.2202C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.2208G>A katG_c.2208G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-221C>A katG_c.-221C>A 1 upstream_gene_variant 2156332 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-221C>G katG_c.-221C>G 1 upstream_gene_variant 2156332 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3423 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-223G>C katG_c.-223G>C 1 upstream_gene_variant 2156334 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3155 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2558 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-225G>A katG_c.-225G>A 1 upstream_gene_variant 2156336 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.228G>C katG_c.228G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.228G>T katG_c.228G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.63548263289195 0.137183409715989 155.34952410964 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-229G>A katG_c.-229G>A 1 upstream_gene_variant 2156340 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.231G>A katG_c.231G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-231G>A katG_c.-231G>A 1 upstream_gene_variant 2156342 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3021 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2456 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-231G>C katG_c.-231G>C 1 upstream_gene_variant 2156342 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3424 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-233C>A katG_c.-233C>A 1 upstream_gene_variant 2156344 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2963 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2411 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-233C>G katG_c.-233C>G 1 upstream_gene_variant 2156344 1 2 1 1 3 1 20843 27467 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999963594000291 0.999797175631493 0.999999078280314 0.75 0.194120449683243 0.99369053679029 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.31780453869404 0.0167943627710572 103.367026597726 1 1253.5 5574 False False 3.95341361608213 0.31739219148065 207.323829234655 4.79754365764728e-05 1.21463215353938e-06 0.000267272712750976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2743 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.237C>T katG_c.237C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-242C>T katG_c.-242C>T 1 upstream_gene_variant 2156353 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-243_-242delGC katG_c.-243_-242delGC 1 upstream_gene_variant 2156352 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3360 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2717 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-243G>A katG_c.-243G>A 1 upstream_gene_variant 2156354 0 0 0 0 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3217 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2605 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-244C>T katG_c.-244C>T 1 upstream_gene_variant 2156355 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-246C>T katG_c.-246C>T 1 upstream_gene_variant 2156357 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-247G>A katG_c.-247G>A 1 upstream_gene_variant 2156358 0 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3347 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2707 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-249T>C katG_c.-249T>C 1 upstream_gene_variant 2156360 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3111 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-249T>G katG_c.-249T>G 1 upstream_gene_variant 2156360 0 0 0 0 2 2 20844 27466 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999927188000582 0.999737003036386 0.999991182007438 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3177 5574 False False 1.3176933410094 0.0955278435529395 18.1762534351792 0 0 0.000176959943030976 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 2 13372 21311 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999906160559283 0.999661061221376 0.999988635406343 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2576 4479 False False 0 0 0 0 0 0 0 1.59370326054442 0.115491055908661 21.9865025501046 0 0 0.000275827900298067 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-250G>T katG_c.-250G>T 1 upstream_gene_variant 2156361 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3081 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2503 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-253T>G katG_c.-253T>G 1 upstream_gene_variant 2156364 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-256G>A katG_c.-256G>A 1 upstream_gene_variant 2156367 1 3 1 2 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.658815063564403 0.011171855707321 12.6567401482543 1 2027.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.796792043670081 0.0135099696349484 15.307558728263 1 1642.5 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-258C>A katG_c.-258C>A 1 upstream_gene_variant 2156369 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3453 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2787 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-259T>G katG_c.-259T>G 1 upstream_gene_variant 2156370 1 9 1 8 1 8 20845 27460 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.99970875200233 0.999426206431739 0.999874251669172 0.111111111111111 0.00280913674659921 0.482496514917337 0.111111111111111 0.00280913674659921 0.482496514917337 0.111111111111111 0.00280913674659921 0.482496514917337 0.164667786039817 0.00371513512243138 1.22846047298172 0.0876207085070134 291 5574 False False 0.164667786039817 0.00371513512243138 1.22846047298172 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.99970875200233 0.999426206431739 0.999874251669172 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 13374 21308 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.73894646374006 0.163960020972012 248.5 4479 False False 0 0 0 0 0 0 0 0 0 1.73894646374006 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-261C>G katG_c.-261C>G 1 upstream_gene_variant 2156372 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3156 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2559 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.261G>A katG_c.261G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.267G>A katG_c.267G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.18865318395302 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-268A>G katG_c.-268A>G 1 upstream_gene_variant 2156379 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-273_-272dupGA katG_c.-273_-272dupGA 1 upstream_gene_variant 2156382 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2964 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2412 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-273G>A katG_c.-273G>A 1 upstream_gene_variant 2156384 1 6 0 6 1 6 20845 27462 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999781564001747 0.999524617886493 0.999919833755107 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.11906289991934 0.040214073694581 205 5574 False False 0.219573039098105 0.00477770915407814 1.81014820057657 0 0 0.000176951454458875 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 1 4 13373 21309 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999812321118566 0.999519537882235 0.999948861529775 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.41438473582549 0.305470176578709 427 4479 False False 0 0 0 0 0 0 0 0.398358633066626 0.00809276091420046 4.02622197901862 0 0 0.000275807277411719 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-274C>T katG_c.-274C>T 1 upstream_gene_variant 2156385 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3470 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.276C>T katG_c.276C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-278G>C katG_c.-278G>C 1 upstream_gene_variant 2156389 1 4 0 4 81 377 20765 27091 0.00388563753238031 0.00308691863464751 0.00482721207343989 0.9862749381098 0.984828188808172 0.98761742950962 0.176855895196506 0.143003152099351 0.214945501711041 0 0 0.602364635616474 0 0 0.00973711048356851 0 0 1.97664583702136 0.138142265723218 NA NA False True 0.280308824083577 0.21754905557951 0.3574629385585 0 0 0.000177633123564814 0.9862749381098 0.984828188808172 0.98761742950962 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 1 0 1 58 258 13316 21055 0.00433677284282937 0.00329469110009793 0.00560272373466386 0.987894712147515 0.986334661701761 0.98931947535394 0.183544303797468 0.142423633963088 0.230712672421896 0 0 0.975 0 0 0.0141962516553948 0 0 61.6105657614188 1 NA NA False True 0 1 1 0 0 1 0 0.355459189970217 0.26238173350702 0.474661963990184 0 0 0.0002769877247944 0.987894712147515 0.986334661701761 0.98931947535394 7 Not assoc w RI 5) Not assoc w R UP from NotAwRI to NotAwR yes 4 +Isoniazid katG c.27A>G katG_c.27A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-27A>G katG_c.-27A>G 1 upstream_gene_variant 2156138 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3241 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2625 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 1 3) Uncertain significance No change no 1 +Isoniazid katG c.27A>T katG_c.27A>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.282C>T katG_c.282C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-282G>A katG_c.-282G>A 1 upstream_gene_variant 2156393 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-284G>A katG_c.-284G>A 1 upstream_gene_variant 2156395 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-287C>T katG_c.-287C>T 1 upstream_gene_variant 2156398 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3392 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2744 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.288C>T katG_c.288C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 4 20844 27464 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999854376001165 0.999627187086024 0.999960320981843 0.333333333333333 0.0432718682927417 0.777221904496487 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.658798695068125 0.0595601499680727 4.59736120623929 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.85651838973546 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-289G>A katG_c.-289G>A 1 upstream_gene_variant 2156400 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-28G>A katG_c.-28G>A 1 upstream_gene_variant 2156139 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3157 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-28G>T katG_c.-28G>T 1 upstream_gene_variant 2156139 1 4 0 4 1 4 20845 27464 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999854376001165 0.999627187086024 0.999960320981843 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 1.99614374716563 0.139122901336525 342.5 5574 False False 0.329383545214679 0.00669260119676484 3.32889360843958 0 0 0.000176951454458875 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-291C>G katG_c.-291C>G 1 upstream_gene_variant 2156402 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-292A>G katG_c.-292A>G 1 upstream_gene_variant 2156403 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3218 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2606 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-293G>A katG_c.-293G>A 1 upstream_gene_variant 2156404 1 9 0 9 1 9 20845 27459 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999672346002621 0.99937810218515 0.999850165132458 0.1 0.00252857854446178 0.445016117028195 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.667480744536141 0.012862046679265 139.5 5574 False False 0.146366035020388 0.00334344690875921 1.0564499909134 0 0 0.000176951454458875 0.999672346002621 0.99937810218515 0.999850165132458 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 1 8 13373 21305 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999624642237132 0.999260530264256 0.999837933676441 0.111111111111111 0.00280913674659921 0.482496514917337 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.933509756057677 0.0270169688512467 122 4479 False False 0 0 0 0 0 0 0 0.199141927764899 0.00449176289276445 1.48571302597227 0 0 0.000275807277411719 0.999624642237132 0.999260530264256 0.999837933676441 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.294C>T katG_c.294C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-296C>G katG_c.-296C>G 1 upstream_gene_variant 2156407 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-296C>T katG_c.-296C>T 1 upstream_gene_variant 2156407 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.297G>T katG_c.297G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-299T>C katG_c.-299T>C 1 upstream_gene_variant 2156410 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-29C>A katG_c.-29C>A 1 upstream_gene_variant 2156140 1 4 0 4 1 4 20845 27464 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999854376001165 0.999627187086024 0.999960320981843 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 1.99614374716563 0.139122901336525 342.5 5574 False False 0.329383545214679 0.00669260119676484 3.32889360843958 0 0 0.000176951454458875 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 3 13373 21310 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999859240838924 0.999588697652472 0.999970971136275 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85680682534852 0.289279625558287 389.5 4479 False False 0 0 0 0 0 0 0 0.531169769934445 0.010122018243966 6.61631049307563 0 0 0.000275807277411719 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-2C>T katG_c.-2C>T 1 upstream_gene_variant 2156113 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance No change no 1 +Isoniazid katG c.-302G>C katG_c.-302G>C 1 upstream_gene_variant 2156413 1 4 0 4 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 1.99604811372315 0.139118032244638 322.5 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.41420404242617 0.305473156458586 444 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-304_-303dupCT katG_c.-304_-303dupCT 1 upstream_gene_variant 2156413 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3258 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-304C>A katG_c.-304C>A 1 upstream_gene_variant 2156415 0 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3393 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2745 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-308C>T katG_c.-308C>T 1 upstream_gene_variant 2156419 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-309A>G katG_c.-309A>G 1 upstream_gene_variant 2156420 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-310G>T katG_c.-310G>T 1 upstream_gene_variant 2156421 1 4 0 4 1 5 20845 27463 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999817970001456 0.999575254267103 0.999940892797913 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.602364635616474 0 0 0.521823750104981 0 0 1.9960711666997 0.139119205469767 335 5574 False False 0.263497241544735 0.00557522895465965 2.35509564487831 0 0 0.000176951454458875 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.85633740727807 0.289259828934126 294 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 1 3) Uncertain significance No change no 1 +Isoniazid katG c.-316G>A katG_c.-316G>A 1 upstream_gene_variant 2156427 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-317C>A katG_c.-317C>A 1 upstream_gene_variant 2156428 1 1 0 1 5 1 20841 27467 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.999963594000291 0.999797175631493 0.999999078280314 0.833333333333333 0.358765421002325 0.99578925548551 0 0 0.975 0 0 0.975 0 0 51.360732841256 1 2027.5 5574 False False 6.58965500695744 0.737267067818355 311.215258952954 0 0 0.000176985413634466 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 1 13371 21312 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999953080279641 0.999738608085756 0.999998812096234 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 62.1055547471297 1 1642.5 4479 False False 0 0 0 0 0 0 0 4.78169172088849 0.383875689805931 250.696170545132 0 0 0.000275848526268708 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-318C>T katG_c.-318C>T 1 upstream_gene_variant 2156429 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-31C>T katG_c.-31C>T 1 upstream_gene_variant 2156142 1 6 0 6 2 7 20844 27461 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999745158002038 0.999474999027776 0.999897534357495 0.222222222222222 0.0281449734778982 0.600093573716312 0 0 0.4592581264399 0 0 0.409616397225003 0 0 1.11907584135889 0.0402148300153378 210 5574 False False 0.376415275379005 0.0381509889597215 1.97729867984898 0 0 0.000176959943030976 0.999745158002038 0.999474999027776 0.999897534357495 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 2 7 13372 21306 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.99967156195749 0.999323409938814 0.999867941002665 0.222222222222222 0.0281449734778982 0.600093573716312 0 0 0.4592581264399 0 0 0.409616397225003 0 0 1.35349447126629 0.0884843124151618 180 4479 False False 0 0 0 0 0 0 0 0.455236955685654 0.0461387128464925 2.39147917078199 0 0 0.000275827900298067 0.99967156195749 0.999323409938814 0.999867941002665 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-323G>A katG_c.-323G>A 1 upstream_gene_variant 2156434 1 1 0 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 51.3533466119536 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 62.1009148060541 1 1642.5 4479 False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 0 0 0.000275827900298067 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-324G>A katG_c.-324G>A 1 upstream_gene_variant 2156435 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3287 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-325C>G katG_c.-325C>G 1 upstream_gene_variant 2156436 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3272 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-325C>T katG_c.-325C>T 1 upstream_gene_variant 2156436 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3334 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2698 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-326C>T katG_c.-326C>T 1 upstream_gene_variant 2156437 1 18 0 18 0 19 20846 27449 0 0 0.00017694296670111 0.999308286005533 0.998920012739518 0.999583493240977 0 0 0.176466911806965 0 0 0.185301968137852 0 0 0.176466911806965 0 0 0.299517545169012 4.50254254438285e-05 56 5574 True False 0 0 0.282203610593972 0 0 0.00017694296670111 0.999308286005533 0.998920012739518 0.999583493240977 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 18 0 18 0 19 13374 21294 0 0 0.000275786657608973 0.999108525313189 0.998608200368116 0.999463191365845 0 0 0.176466911806965 0 0 0.185301968137852 0 0 0.176466911806965 0 0 0.362221310642961 0.000286818625244429 42 4479 True False 0 0 0 0 0 0 0 0 0 0.341256884077743 0 0 0.000275786657608973 0.999108525313189 0.998608200368116 0.999463191365845 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.330C>T katG_c.330C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-331G>A katG_c.-331G>A 1 upstream_gene_variant 2156442 1 3 1 2 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.658815063564403 0.011171855707321 12.6567401482543 1 2027.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.796792043670081 0.0135099696349484 15.307558728263 1 1642.5 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-332delC katG_c.-332delC 1 upstream_gene_variant 2156442 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3426 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-334_-217del katG_c.-334_-217del 1 upstream_gene_variant 2156327 1 47 2 45 5 50 20841 27418 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.998179700014562 0.997600856968635 0.998648645693372 0.0909090909090909 0.0301808678458132 0.1995396157705 0.0425531914893617 0.00519558317674383 0.145405245488214 0.0384615384615384 0.00469228900927086 0.132128407276802 0.0584702162937372 0.0068748104564768 0.223870417833359 2.36312330776677e-09 19 5574 True False 0.131557986660908 0.0409359175133517 0.328056761577745 9.59554766588303e-05 1.16208646408031e-05 0.00034658073323929 0.998179700014562 0.997600856968635 0.998648645693372 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 32 2 30 4 33 13370 21280 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 0.99845164922817 0.997826220679006 0.998933954302094 0.108108108108108 0.0302519650687496 0.254175936077478 0.0625 0.00766073634645639 0.208069429895007 0.0571428571428571 0.00699676362830951 0.191571406345239 0.10610820244328 0.0122859485159929 0.418333943709427 6.724405546378e-05 34 4479 True False 0 0 0 0 0 0 0 0.192924004442329 0.0496683039666435 0.542619657403595 0.000149566257852228 1.81136809684436e-05 0.000540179209988093 0.99845164922817 0.997826220679006 0.998933954302094 1 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-334G>A katG_c.-334G>A 1 upstream_gene_variant 2156445 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3506 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2821 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-336C>T katG_c.-336C>T 1 upstream_gene_variant 2156447 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3112 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-337C>A katG_c.-337C>A 1 upstream_gene_variant 2156448 2 3 0 3 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18880616510555 0.264079043314886 541.5 5574 False False 0.439194051331254 0.00837049629364692 5.4704842261679 0 0 0.000176951454458875 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 3 0 3 1 3 13373 21310 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999859240838924 0.999588697652472 0.999970971136275 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85680682534852 0.289279625558287 389.5 4479 False False 0 0 0 0 0 0 0 0.531169769934445 0.010122018243966 6.61631049307563 0 0 0.000275807277411719 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-338_-241delGCCCGACGTATCCCGGCAAGCCGTGTACGACGTGCTGCATGCCCTGACCGCCGCGGGCTTGGTGCGAAAGATCCAACCCTCGGGCTCCGTCGCGCGCT katG_c.-338_-241delGCCCGACGTATCCCGGCAAGCCGTGTACGACGTGCTGCATGCCCTGACCGCCGCGGGCTTGGTGCGAAAGATCCAACCCTCGGGCTCCGTCGCGCGCT 1 upstream_gene_variant 2156351 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3348 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2708 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.339C>T katG_c.339C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-339T>C katG_c.-339T>C 1 upstream_gene_variant 2156450 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3113 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2527 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-340C>T katG_c.-340C>T 1 upstream_gene_variant 2156451 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-342C>T katG_c.-342C>T 1 upstream_gene_variant 2156453 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-343dupG katG_c.-343dupG 1 upstream_gene_variant 2156453 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3471 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2801 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance No change no 1 +Isoniazid katG c.-344T>C katG_c.-344T>C 1 upstream_gene_variant 2156455 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-345T>C katG_c.-345T>C 1 upstream_gene_variant 2156456 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3022 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2457 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-347T>C katG_c.-347T>C 1 upstream_gene_variant 2156458 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-349C>A katG_c.-349C>A 1 upstream_gene_variant 2156460 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-349C>T katG_c.-349C>T 1 upstream_gene_variant 2156460 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3507 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2822 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-34C>T katG_c.-34C>T 1 upstream_gene_variant 2156145 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3062 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2486 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-350G>A katG_c.-350G>A 1 upstream_gene_variant 2156461 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-352G>A katG_c.-352G>A 1 upstream_gene_variant 2156463 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3377 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2731 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-354C>T katG_c.-354C>T 1 upstream_gene_variant 2156465 1 1 0 1 4 76 20842 27392 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.997233144022134 0.996538073331353 0.997819431632203 0.05 0.0137893939764618 0.123098736443152 0 0 0.975 0 0 0.0473787538669306 0 0 51.21815156483 1 NA NA False True 0.0691720665255885 0.0183586144753074 0.184518555911175 0 0 0.000176976922618654 0.997233144022134 0.996538073331353 0.997819431632203 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 1 0 1 3 67 13371 21246 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.996856378735982 0.996009406983264 0.997562931367929 0.0428571428571428 0.00892690407765889 0.120178605326586 0 0 0.975 0 0 0.0535696541270968 0 0 61.9134184319869 1 NA NA False True 0 0 1 0 0 1 1 0.0711475157307472 0.0143193428841519 0.217144023506714 0 0 0.000275848526268708 0.996856378735982 0.996009406983264 0.997562931367929 24 Not assoc w R Literature evidence (PMID 32143680) 4) Not assoc w R - Interim DOWN from NotAwR to NotAwRI yes Lit. (PMID 32143680) 3 +Isoniazid katG c.-355G>A katG_c.-355G>A 1 upstream_gene_variant 2156466 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-356T>G katG_c.-356T>G 1 upstream_gene_variant 2156467 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3288 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2657 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.357C>T katG_c.357C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.247471899512553 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-357G>A katG_c.-357G>A 1 upstream_gene_variant 2156468 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3454 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2788 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-35A>G katG_c.-35A>G 1 upstream_gene_variant 2156146 1 5 1 4 11 4 20835 27464 0.000527679171063993 0.000263444034397523 0.000943967185544106 0.999854376001165 0.999627187086024 0.999960320981843 0.733333333333333 0.448996758963029 0.922128453708956 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 0.329541636669066 0.00669581067295596 3.33049144334872 0.398317079722337 585 5574 False False 3.62495800335973 1.07391529697927 15.6057775900828 4.79938567863313e-05 1.21509851230904e-06 0.000267375321079624 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 10 4 13364 21309 0.000747719455660236 0.000358616922835118 0.00137465137870696 0.999812321118566 0.999519537882235 0.999948861529775 0.714285714285714 0.418964742816338 0.916110681692872 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.41601219909909 0.305443469083528 418 4479 False False 0 0 0 0 0 0 0 3.98626908111343 1.14940921033945 17.4090409327703 0 0 0.000275992994481552 0.999812321118566 0.999519537882235 0.999948861529775 1 3) Uncertain significance No change no 1 +Isoniazid katG c.360C>A katG_c.360C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.363C>T katG_c.363C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-363T>A katG_c.-363T>A 1 upstream_gene_variant 2156474 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3455 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2789 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-364A>G katG_c.-364A>G 1 upstream_gene_variant 2156475 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3508 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.366C>A katG_c.366C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.369G>A katG_c.369G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-36C>T katG_c.-36C>T 1 upstream_gene_variant 2156147 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-370G>A katG_c.-370G>A 1 upstream_gene_variant 2156481 1 5 0 5 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.43785249906968 0.0743380732312645 251 5574 False False 0 0 1.43785249906968 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 13374 21308 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.73894646374006 0.163960020972012 248.5 4479 False False 0 0 0 0 0 0 0 0 0 1.73894646374006 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-371G>A katG_c.-371G>A 1 upstream_gene_variant 2156482 1 6 0 6 2 6 20844 27462 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999781564001747 0.999524617886493 0.999919833755107 0.25 0.0318540262499442 0.650855794412824 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.1191165871845 0.0402172121873491 212 5574 False False 0.439167146421032 0.0433460282809438 2.45619176778693 0 0 0.000176959943030976 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.41420404242617 0.305473156458586 444 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 3 3) Uncertain significance No change no 1 +Isoniazid katG c.372C>T katG_c.372C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-372C>T katG_c.-372C>T 1 upstream_gene_variant 2156483 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3195 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-373A>C katG_c.-373A>C 1 upstream_gene_variant 2156484 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3196 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2589 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-373A>G katG_c.-373A>G 1 upstream_gene_variant 2156484 0 0 0 0 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3301 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2672 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-375A>G katG_c.-375A>G 1 upstream_gene_variant 2156486 0 0 0 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3197 5574 False False Inf 0.869878292971449 Inf 0 0 0.000176976922618654 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-377C>T katG_c.-377C>T 1 upstream_gene_variant 2156488 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-378C>G katG_c.-378C>G 1 upstream_gene_variant 2156489 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-379G>A katG_c.-379G>A 1 upstream_gene_variant 2156490 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-37T>G katG_c.-37T>G 1 upstream_gene_variant 2156148 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3335 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-382C>T katG_c.-382C>T 1 upstream_gene_variant 2156493 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3259 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2636 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-395G>A katG_c.-395G>A 1 upstream_gene_variant 2156506 1 1 0 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 51.3533466119536 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-395G>C katG_c.-395G>C 1 upstream_gene_variant 2156506 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3158 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2560 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-397G>T katG_c.-397G>T 1 upstream_gene_variant 2156508 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-398A>C katG_c.-398A>C 1 upstream_gene_variant 2156509 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-399C>T katG_c.-399C>T 1 upstream_gene_variant 2156510 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-3G>A katG_c.-3G>A 1 upstream_gene_variant 2156114 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-402A>C katG_c.-402A>C 1 upstream_gene_variant 2156513 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-403G>A katG_c.-403G>A 1 upstream_gene_variant 2156514 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-406C>A katG_c.-406C>A 1 upstream_gene_variant 2156517 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Isoniazid katG c.-407C>T katG_c.-407C>T 1 upstream_gene_variant 2156518 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3427 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-409G>C katG_c.-409G>C 1 upstream_gene_variant 2156520 0 0 0 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3336 5574 False False Inf 0.869878292971449 Inf 0 0 0.000176976922618654 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2699 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-40T>C katG_c.-40T>C 1 upstream_gene_variant 2156151 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2561 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.411C>T katG_c.411C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-411C>T katG_c.-411C>T 1 upstream_gene_variant 2156522 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.414C>T katG_c.414C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.417C>T katG_c.417C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-418C>T katG_c.-418C>T 1 upstream_gene_variant 2156529 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3047 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.421_423delTTGinsCTC katG_c.421_423delTTGinsCTC 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-421C>A katG_c.-421C>A 1 upstream_gene_variant 2156532 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2965 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-423G>A katG_c.-423G>A 1 upstream_gene_variant 2156534 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-425C>G katG_c.-425C>G 1 upstream_gene_variant 2156536 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-428_-414delGACCCGACCGCGCGT katG_c.-428_-414delGACCCGACCGCGCGT 1 upstream_gene_variant 2156524 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3456 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2790 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-428G>A katG_c.-428G>A 1 upstream_gene_variant 2156539 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3489 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-431C>G katG_c.-431C>G 1 upstream_gene_variant 2156542 0 0 0 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3457 5574 False False Inf 0.869878292971449 Inf 0 0 0.000176976922618654 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2791 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-432G>A katG_c.-432G>A 1 upstream_gene_variant 2156543 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-434G>A katG_c.-434G>A 1 upstream_gene_variant 2156545 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-437C>T katG_c.-437C>T 1 upstream_gene_variant 2156548 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.439C>T katG_c.439C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-441C>T katG_c.-441C>T 1 upstream_gene_variant 2156552 1 13 0 13 15 14 20831 27454 0.000719562505996354 0.000402787826414311 0.00118653165660568 0.999490316004077 0.999144984581285 0.999721323894632 0.517241379310344 0.325314996361456 0.705514417048159 0 0 0.24705263800047 0 0 0.231635761650116 0 0 0.432523569493796 0.000973725228330791 75 5574 False False 1.4120781527531 0.635310250357897 3.15848645515695 0 0 0.000177070368626196 0.999490316004077 0.999144984581285 0.999721323894632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 6 7 13368 21306 0.000448631673396141 0.000164657143425453 0.000976224581517196 0.99967156195749 0.999323409938814 0.999867941002665 0.461538461538461 0.192232441801288 0.748654517729696 0 0 0.4592581264399 0 0 0.409616397225003 0 0 1.3538993488862 0.0884927123895277 187 4479 False False 0 0 0 0 0 0 0 1.36611951782508 0.379201975087771 4.74864481757537 0 0 0.00027591042269331 0.99967156195749 0.999323409938814 0.999867941002665 1 3) Uncertain significance No change no 1 +Isoniazid katG c.-443G>A katG_c.-443G>A 1 upstream_gene_variant 2156554 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-445A>T katG_c.-445A>T 1 upstream_gene_variant 2156556 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-447G>A katG_c.-447G>A 1 upstream_gene_variant 2156558 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-449C>T katG_c.-449C>T 1 upstream_gene_variant 2156560 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-451C>T katG_c.-451C>T 1 upstream_gene_variant 2156562 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2966 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2413 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-452G>A katG_c.-452G>A 1 upstream_gene_variant 2156563 1 5 2 3 2 3 20844 27465 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999890782000873 0.99968085216583 0.999977476056514 0.4 0.0527449505263169 0.853367200365326 0.4 0.0527449505263169 0.853367200365326 0.4 0.0527449505263169 0.853367200365326 0.878430243715217 0.0733354884838472 7.66963698207431 1 2027.5 5574 False False 0.878430243715217 0.0733354884838472 7.66963698207431 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 2 3 2 3 13372 21310 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999859240838924 0.999588697652472 0.999970971136275 0.4 0.0527449505263169 0.853367200365326 0.4 0.0527449505263169 0.853367200365326 0.4 0.0527449505263169 0.853367200365326 1.06241898494366 0.0886985485353837 9.27715037564111 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.06241898494366 0.0886985485353837 9.27715037564111 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.453C>A katG_c.453C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-455A>G katG_c.-455A>G 1 upstream_gene_variant 2156566 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-458C>T katG_c.-458C>T 1 upstream_gene_variant 2156569 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3490 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-458dupC katG_c.-458dupC 1 upstream_gene_variant 2156568 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3005 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2446 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-459C>A katG_c.-459C>A 1 upstream_gene_variant 2156570 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-459C>T katG_c.-459C>T 1 upstream_gene_variant 2156570 1 3 0 3 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18880616510555 0.264079043314886 541.5 5574 False False 0.439194051331254 0.00837049629364692 5.4704842261679 0 0 0.000176951454458875 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-45A>G katG_c.-45A>G 1 upstream_gene_variant 2156156 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-460G>T katG_c.-460G>T 1 upstream_gene_variant 2156571 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-461C>T katG_c.-461C>T 1 upstream_gene_variant 2156572 1 2 1 1 1 5 20845 27463 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999817970001456 0.999575254267103 0.999940892797913 0.166666666666666 0.00421074451448947 0.641234578997674 0.5 0.012579117093425 0.987420882906574 0.166666666666666 0.00421074451448947 0.641234578997674 1.31748620772367 0.0167903078444505 103.342078622054 1 2027.5 5574 False False 0.263497241544735 0.00557522895465965 2.35509564487831 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 5 13373 21308 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999765401398207 0.999452610763328 0.999923822225278 0.166666666666666 0.00421074451448947 0.641234578997674 0.5 0.012579117093425 0.987420882906574 0.166666666666666 0.00421074451448947 0.641234578997674 1.59335975472967 0.0202967475317387 124.960380636392 1 1642.5 4479 False False 0 0 0 0 0 0 0 0.318671950945935 0.00674139558547252 2.84834809554519 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999765401398207 0.999452610763328 0.999923822225278 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.462G>A katG_c.462G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-463T>C katG_c.-463T>C 1 upstream_gene_variant 2156574 1 2 0 2 3 2 20843 27466 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999927188000582 0.999737003036386 0.999991182007438 0.6 0.146632799634673 0.947255049473683 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01699856622015 0.509392482788101 1176.5 5574 False False 1.97663484143357 0.226402568392661 23.6672561646805 0 0 0.00017696843241753 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2658 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-466G>C katG_c.-466G>C 1 upstream_gene_variant 2156577 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3023 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2458 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-467G>A katG_c.-467G>A 1 upstream_gene_variant 2156578 1 3 0 3 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.18853708762714 0.264070532102877 442 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.85633740727807 0.289259828934126 294 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.468C>T katG_c.468C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-468C>T katG_c.-468C>T 1 upstream_gene_variant 2156579 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-473T>G katG_c.-473T>G 1 upstream_gene_variant 2156584 1 7 1 6 2 6 20844 27462 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999781564001747 0.999524617886493 0.999919833755107 0.25 0.0318540262499442 0.650855794412824 0.142857142857142 0.00361029686190058 0.578723197043195 0.142857142857142 0.00361029686190058 0.578723197043195 0.219583573210516 0.00477793811024463 1.81023488574266 0.251119904361686 422 5574 False False 0.439167146421032 0.0433460282809438 2.45619176778693 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 1 4 1 4 13373 21309 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999812321118566 0.999519537882235 0.999948861529775 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 0.398358633066626 0.00809276091420046 4.02622197901862 0.655130892896639 995 4479 False False 0 0 0 0 0 0 0 0.398358633066626 0.00809276091420046 4.02622197901862 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-475T>A katG_c.-475T>A 1 upstream_gene_variant 2156586 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-475T>C katG_c.-475T>C 1 upstream_gene_variant 2156586 1 2 0 2 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01632529799099 0.509386028876591 1135.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-475T>G katG_c.-475T>G 1 upstream_gene_variant 2156586 1 4 0 4 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 1.99604811372315 0.139118032244638 322.5 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 1 3) Uncertain significance No change no 1 +Isoniazid katG c.-477C>T katG_c.-477C>T 1 upstream_gene_variant 2156588 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-478T>C katG_c.-478T>C 1 upstream_gene_variant 2156589 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-479_-478delGT katG_c.-479_-478delGT 1 upstream_gene_variant 2156588 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-479G>A katG_c.-479G>A 1 upstream_gene_variant 2156590 0 0 0 0 7 0 20839 27468 0.000335795836131632 0.000135017659185429 0.000691744589626827 1 0.999865711673152 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 3273 5574 False False Inf 1.89951899263229 Inf 0 0 0.00017700239811062 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 6 0 13368 21313 0.000448631673396141 0.000164657143425453 0.000976224581517196 1 0.999826933785262 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 2645 4479 False False 0 0 0 0 0 0 0 Inf 1.87681913692541 Inf 0 0 0.00027591042269331 1 0.999826933785262 1 2 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-479G>T katG_c.-479G>T 1 upstream_gene_variant 2156590 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-47A>C katG_c.-47A>C 1 upstream_gene_variant 2156158 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3319 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2684 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-480T>C katG_c.-480T>C 1 upstream_gene_variant 2156591 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2967 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2414 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-480T>G katG_c.-480T>G 1 upstream_gene_variant 2156591 1 1 1 0 8 0 20838 27468 0.000383766669864722 0.000165697303700768 0.000756032532322191 1 0.999865711673152 1 1 0.63058335244718 1 1 0.025 1 1 0.025 1 Inf 0.0337973065466778 Inf 0.431386755542675 602.5 5574 False False Inf 2.24970730189478 Inf 4.79869475502663e-05 1.21492358580957e-06 0.000267336833725155 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 6 0 13368 21313 0.000448631673396141 0.000164657143425453 0.000976224581517196 1 0.999826933785262 1 1 0.540741873560099 1 1 0.025 1 1 0.025 1 Inf 0.0408769722035076 Inf 0.385473732772043 479.5 4479 False False 0 0 0 0 0 0 0 Inf 1.87681913692541 Inf 7.47999102401077e-05 1.89376797152033e-06 0.000416687175469531 1 0.999826933785262 1 3 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-481G>T katG_c.-481G>T 1 upstream_gene_variant 2156592 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-482T>A katG_c.-482T>A 1 upstream_gene_variant 2156593 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3123 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2536 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-482T>G katG_c.-482T>G 1 upstream_gene_variant 2156593 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3509 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2823 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-483G>A katG_c.-483G>A 1 upstream_gene_variant 2156594 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3219 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2607 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-485_-484insTGTCT katG_c.-485_-484insTGTCT 1 upstream_gene_variant 2156595 1 3 3 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.544526627735454 Inf 0.0803181469117723 287 5574 False False Inf 0.544526627735454 Inf 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG c.-485T>G katG_c.-485T>G 1 upstream_gene_variant 2156596 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-486C>T katG_c.-486C>T 1 upstream_gene_variant 2156597 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-487T>C katG_c.-487T>C 1 upstream_gene_variant 2156598 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3472 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2802 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-489T>C katG_c.-489T>C 1 upstream_gene_variant 2156600 1 2 0 2 2 2 20844 27466 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999927188000582 0.999737003036386 0.999991182007438 0.5 0.067585986488543 0.932414013511457 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01666191595533 0.509389255488555 1161.5 5574 False False 1.3176933410094 0.0955278435529395 18.1762534351792 0 0 0.000176959943030976 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 2 2 13372 21311 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999906160559283 0.999661061221376 0.999988635406343 0.5 0.067585986488543 0.932414013511457 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.4866208667913 0.526194527956412 951.5 4479 False False 0 0 0 0 0 0 0 1.59370326054442 0.115491055908661 21.9865025501046 0 0 0.000275827900298067 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-490T>C katG_c.-490T>C 1 upstream_gene_variant 2156601 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-491A>G katG_c.-491A>G 1 upstream_gene_variant 2156602 0 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3242 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2626 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-493A>G katG_c.-493A>G 1 upstream_gene_variant 2156604 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3243 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-494_-493insGTC katG_c.-494_-493insGTC 1 upstream_gene_variant 2156604 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3048 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2478 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-494C>T katG_c.-494C>T 1 upstream_gene_variant 2156605 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3024 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2459 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.495T>C katG_c.495T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 25 7 20821 27461 0.00119927084332725 0.000776250516059497 0.00176985477840228 0.999745158002038 0.999474999027776 0.999897534357495 0.78125 0.600271736287892 0.90722846771528 NA NA NA NA NA NA NA NA NA NA NA NA False False 4.71038855002161 1.98009029330466 12.9008687337396 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 22 7 13352 21306 0.00164498280245251 0.00103118012105387 0.00248947070088324 0.99967156195749 0.999323409938814 0.999867941002665 0.758620689655172 0.564599654011466 0.897016449227382 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 5.01510742103911 2.06842431123846 13.9045598867908 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-495T>G katG_c.-495T>G 1 upstream_gene_variant 2156606 1 4 0 4 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 1.99604811372315 0.139118032244638 322.5 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-497A>C katG_c.-497A>C 1 upstream_gene_variant 2156608 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-497A>G katG_c.-497A>G 1 upstream_gene_variant 2156608 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3049 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2479 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-497delA katG_c.-497delA 1 upstream_gene_variant 2156607 1 5 0 5 1 5 20845 27463 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999817970001456 0.999575254267103 0.999940892797913 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.43792168895301 0.0743421811498351 266 5574 False False 0.263497241544735 0.00557522895465965 2.35509564487831 0 0 0.000176951454458875 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 1 5 13373 21308 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999765401398207 0.999452610763328 0.999923822225278 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.73907646387712 0.163960168380046 259.5 4479 False False 0 0 0 0 0 0 0 0.318671950945935 0.00674139558547252 2.84834809554519 0 0 0.000275807277411719 0.999765401398207 0.999452610763328 0.999923822225278 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-498delG katG_c.-498delG 1 upstream_gene_variant 2156608 1 2 0 2 7 2 20839 27466 0.000335795836131632 0.000135017659185429 0.000691744589626827 0.999927188000582 0.999737003036386 0.999991182007438 0.777777777777777 0.399906426283687 0.971855026522101 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01834549037735 0.509405398863652 1204.5 5574 False False 4.61303325495465 0.87817476276209 45.5132476135674 0 0 0.00017700239811062 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 4 1 13370 21312 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 0.999953080279641 0.999738608085756 0.999998812096234 0.8 0.28358206388191 0.994949236620532 0 0 0.975 0 0 0.975 0 0 62.1101953816142 1 1642.5 4479 False False 0 0 0 0 0 0 0 6.37606581899775 0.630846560224411 313.513380938872 0 0 0.000275869155324334 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-499G>A katG_c.-499G>A 1 upstream_gene_variant 2156610 1 3 0 3 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18880616510555 0.264079043314886 541.5 5574 False False 0.439194051331254 0.00837049629364692 5.4704842261679 0 0 0.000176951454458875 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-499G>T katG_c.-499G>T 1 upstream_gene_variant 2156610 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3274 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2646 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-49T>C katG_c.-49T>C 1 upstream_gene_variant 2156160 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3491 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2813 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-4T>G katG_c.-4T>G 1 upstream_gene_variant 2156115 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3260 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-500G>T katG_c.-500G>T 1 upstream_gene_variant 2156611 1 4 0 4 1 4 20845 27464 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999854376001165 0.999627187086024 0.999960320981843 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 1.99614374716563 0.139122901336525 342.5 5574 False False 0.329383545214679 0.00669260119676484 3.32889360843958 0 0 0.000176951454458875 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 1 4 13373 21309 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999812321118566 0.999519537882235 0.999948861529775 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.41438473582549 0.305470176578709 427 4479 False False 0 0 0 0 0 0 0 0.398358633066626 0.00809276091420046 4.02622197901862 0 0 0.000275807277411719 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-501delA katG_c.-501delA 1 upstream_gene_variant 2156611 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-503A>C katG_c.-503A>C 1 upstream_gene_variant 2156614 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3142 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2547 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-504A>G katG_c.-504A>G 1 upstream_gene_variant 2156615 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-505G>C katG_c.-505G>C 1 upstream_gene_variant 2156616 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3337 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2700 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-506A>T katG_c.-506A>T 1 upstream_gene_variant 2156617 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3094 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2513 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-507C>G katG_c.-507C>G 1 upstream_gene_variant 2156618 1 1 0 1 334 1 20512 27467 0.0160222584668521 0.01436154658556 0.0178198436433385 0.999963594000291 0.999797175631493 0.999999078280314 0.997014925373134 0.983481270428202 0.999924427309538 0 0 0.975 0 0 0.975 0 0 52.1838560469916 1 1253.5 5574 False False 447.249317472698 79.6655286081196 15642.2530416526 0 0 0.000179823896735254 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 294 1 13080 21312 0.0219829519964109 0.019564961770868 0.0246119127478923 0.999953080279641 0.999738608085756 0.999998812096234 0.996610169491525 0.981258771569458 0.999914180604782 0 0 0.975 0 0 0.975 0 0 63.4858902893673 1 1642.5 4479 False False 0 0 0 0 0 0 0 479.03119266055 85.2905327843301 16383.9999999403 0 0 0.000281984657948119 0.999953080279641 0.999738608085756 0.999998812096234 6 3) Uncertain significance No change no 1 +Isoniazid katG c.-507C>T katG_c.-507C>T 1 upstream_gene_variant 2156618 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3394 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2746 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-508C>G katG_c.-508C>G 1 upstream_gene_variant 2156619 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3025 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-510T>C katG_c.-510T>C 1 upstream_gene_variant 2156621 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3124 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-511A>G katG_c.-511A>G 1 upstream_gene_variant 2156622 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3006 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-512G>A katG_c.-512G>A 1 upstream_gene_variant 2156623 1 11 0 11 0 11 20846 27457 0 0 0.00017694296670111 0.999599534003203 0.9992835689522 0.999800072407065 0 0 0.284914152918154 0 0 0.284914152918154 0 0 0.284914152918154 0 0 0.524869354994364 0.00349745110870105 101 5574 False False 0 0 0.524869354994364 0 0 0.00017694296670111 0.999599534003203 0.9992835689522 0.999800072407065 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 0 10 13374 21303 0 0 0.000275786657608973 0.999530802796415 0.99913729947772 0.999774979505452 0 0 0.30849710781876 0 0 0.30849710781876 0 0 0.30849710781876 0 0 0.710765762832934 0.00889128586048643 77 4479 False False 0 0 0 0 0 0 0 0 0 0.710765762832934 0 0 0.000275786657608973 0.999530802796415 0.99913729947772 0.999774979505452 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-516G>A katG_c.-516G>A 1 upstream_gene_variant 2156627 2 1 1 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0337875782094303 Inf 0.431457371721896 645 5574 False False Inf 0.247471899512553 Inf 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2415 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-519C>T katG_c.-519C>T 1 upstream_gene_variant 2156630 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3159 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2562 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-52_-41delCGATCACATCCG katG_c.-52_-41delCGATCACATCCG 1 upstream_gene_variant 2156151 0 0 0 0 5 0 20841 27468 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 1 0.999865711673152 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 3026 5574 False False Inf 1.20760984683633 Inf 0 0 0.000176985413634466 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 5 0 13369 21313 0.000373859727830118 0.000121402023062639 0.000872246401868143 1 0.999826933785262 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 2460 4479 False False 0 0 0 0 0 0 0 Inf 1.46057233596553 Inf 0 0 0.000275889787465637 1 0.999826933785262 1 1 3) Uncertain significance No change no 1 +Isoniazid katG c.-520T>C katG_c.-520T>C 1 upstream_gene_variant 2156631 1 19 0 19 2 19 20844 27449 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999308286005533 0.998920012739518 0.999583493240977 0.0952380952380952 0.0117493178844458 0.303774406913924 0 0 0.176466911806965 0 0 0.176466911806965 0 0 0.282230697279195 2.48553912433502e-05 50 5574 True False 0.138618711430274 0.0156408052773578 0.574694576740207 0 0 0.000176959943030976 0.999308286005533 0.998920012739518 0.999583493240977 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 18 0 18 2 18 13372 21295 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999155445033547 0.998665566208554 0.999499388823668 0.1 0.0123485271702948 0.316982714019082 0 0 0.185301968137852 0 0 0.185301968137852 0 0 0.362292467784877 0.000286819329288701 43 4479 True False 0 0 0 0 0 0 0 0.176945192275733 0.01991301537096 0.73929455480427 0 0 0.000275827900298067 0.999155445033547 0.998665566208554 0.999499388823668 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-521_-488delGTCTTGACTGATTCCAGAAAAGGGAGTCATATTG katG_c.-521_-488delGTCTTGACTGATTCCAGAAAAGGGAGTCATATTG 1 upstream_gene_variant 2156598 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3198 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-521G>T katG_c.-521G>T 1 upstream_gene_variant 2156632 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-522A>C katG_c.-522A>C 1 upstream_gene_variant 2156633 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-527G>A katG_c.-527G>A 1 upstream_gene_variant 2156638 1 2 0 2 1 4 20845 27464 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999854376001165 0.999627187086024 0.999960320981843 0.2 0.00505076337946806 0.716417936118089 0 0 0.841886116991581 0 0 0.602364635616474 0 0 7.01581441470222 0.509381131851925 880 5574 False False 0.329383545214679 0.00669260119676484 3.32889360843958 0 0 0.000176951454458875 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 4 13373 21309 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999812321118566 0.999519537882235 0.999948861529775 0.2 0.00505076337946806 0.716417936118089 0 0 0.841886116991581 0 0 0.602364635616474 0 0 8.48518990407669 0.526176238728858 704.5 4479 False False 0 0 0 0 0 0 0 0.398358633066626 0.00809276091420046 4.02622197901862 0 0 0.000275807277411719 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-530C>T katG_c.-530C>T 1 upstream_gene_variant 2156641 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3473 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2803 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-531G>C katG_c.-531G>C 1 upstream_gene_variant 2156642 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.534C>T katG_c.534C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-53G>T katG_c.-53G>T 1 upstream_gene_variant 2156164 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.540G>A katG_c.540G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.543C>T katG_c.543C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.546G>C katG_c.546G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.549C>T katG_c.549C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.18865318395302 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.85651838973546 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-54C>A katG_c.-54C>A 1 upstream_gene_variant 2156165 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG c.555C>T katG_c.555C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 7 20845 27461 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999745158002038 0.999474999027776 0.999897534357495 0.125 0.0031597235312519 0.526509670875206 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.188198608779083 0.00417990056987037 1.46513319151887 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 7 13373 21306 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.99967156195749 0.999323409938814 0.999867941002665 0.125 0.0031597235312519 0.526509670875206 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.227601457093717 0.00505385949080816 1.77192833352817 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.558C>T katG_c.558C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.570G>A katG_c.570G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.63548263289195 0.137183409715989 155.34952410964 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.579C>A katG_c.579C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.579C>T katG_c.579C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.57C>T katG_c.57C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.99604811372315 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.41420404242617 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.585G>A katG_c.585G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 3 8 20843 27460 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.99970875200233 0.999426206431739 0.999874251669172 0.272727272727272 0.0602177341729066 0.609742559572421 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.494050760447152 0.0844081742669313 2.05877344876832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 7 13373 21306 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.99967156195749 0.999323409938814 0.999867941002665 0.125 0.0031597235312519 0.526509670875206 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.227601457093717 0.00505385949080816 1.77192833352817 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-59C>T katG_c.-59C>T 1 upstream_gene_variant 2156170 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3125 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2537 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.606C>A katG_c.606C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 11 7 20835 27461 0.000527679171063993 0.000263444034397523 0.000943967185544106 0.999745158002038 0.999474999027776 0.999897534357495 0.611111111111111 0.357451205893062 0.827014145210248 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.07117830573554 0.733061837811266 6.30244350700297 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 8 7 13366 21306 0.000598175564528189 0.000258283997825234 0.00117830226263269 0.99967156195749 0.999323409938814 0.999867941002665 0.533333333333333 0.265861347277396 0.787333270480692 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.82176524657446 0.577110136838304 5.90363815458136 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.609C>T katG_c.609C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 20 318 20826 27150 0.000959416674661805 0.000586132014909014 0.00148135424594851 0.988422892092616 0.987086641689673 0.989654268292073 0.059171597633136 0.0365145214428109 0.0899088227960913 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.0819911250269528 0.0494030245853123 0.128854367080631 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 15 290 13359 21023 0.00112157918349035 0.000627870944551516 0.00184920065907577 0.986393281096044 0.984746371991518 0.987905473421792 0.0491803278688524 0.0277836846703669 0.0798190316710554 NA NA NA NA NA NA NA NA NA NA NA NA False True 1 1 1 0 0 0 1 0.0813980501328047 0.0449559229830862 0.136564284199987 NA NA NA NA NA NA 42 5) Not assoc w R Now listed Silent mutation no 0 +Isoniazid katG c.60T>C katG_c.60T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.615C>A katG_c.615C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-62C>A katG_c.-62C>A 1 upstream_gene_variant 2156173 0 0 0 0 79 0 20767 27468 0.00378969586491413 0.0030014514733276 0.00472088618507468 1 0.999865711673152 1 1 0.954378747241388 1 NA NA NA NA NA NA NA NA NA NA 3050 5574 False False Inf 27.672784736402 Inf 0 0 0.00017761601783482 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 17 0 13357 21313 0.0012711230746224 0.000740644897312986 0.00203441363276193 1 0.999826933785262 1 1 0.804935677030906 1 NA NA NA NA NA NA NA NA NA NA 2480 4479 False False 0 0 0 0 0 0 0 Inf 6.58228232638527 Inf 0 0 0.000276137614096336 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-62C>T katG_c.-62C>T 1 upstream_gene_variant 2156173 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.633C>T katG_c.633C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.636T>C katG_c.636T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.247471899512553 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.63C>T katG_c.63C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.646C>T katG_c.646C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.648G>A katG_c.648G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-64T>C katG_c.-64T>C 1 upstream_gene_variant 2156175 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.654C>T katG_c.654C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.663C>T katG_c.663C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 7 20845 27461 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999745158002038 0.999474999027776 0.999897534357495 0.125 0.0031597235312519 0.526509670875206 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.188198608779083 0.00417990056987037 1.46513319151887 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.41420404242617 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.684C>T katG_c.684C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.687C>T katG_c.687C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.690G>C katG_c.690G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-6A>C katG_c.-6A>C 1 upstream_gene_variant 2156117 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3082 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2504 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-6A>G katG_c.-6A>G 1 upstream_gene_variant 2156117 0 0 0 0 23 1 20823 27467 0.00110332917586107 0.000699540579283756 0.00165507836011506 0.999963594000291 0.999797175631493 0.999999078280314 0.958333333333333 0.788798316543026 0.99894564755453 NA NA NA 0 0 0.975 NA NA NA NA 3178 5574 False False 30.3386159535129 4.92542534790948 1242.54352909132 0 0 0.000177138391364407 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 8 1 13366 21312 0.000598175564528189 0.000258283997825234 0.00117830226263269 0.999953080279641 0.999738608085756 0.999998812096234 0.888888888888888 0.517503485082663 0.9971908632534 NA NA NA 0 0 0.975 NA NA NA NA 2577 4479 False False 0 0 0 0 0 0 0 12.7559479275774 1.70975577844451 564.516212294525 0 0 0.000275951702410535 0.999953080279641 0.999738608085756 0.999998812096234 12 3) Uncertain significance No change no 1 +Isoniazid katG c.6C>T katG_c.6C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.702G>A katG_c.702G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.702G>C katG_c.702G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.705G>C katG_c.705G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.723C>A katG_c.723C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.723C>G katG_c.723C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 113 88 20733 27380 0.0054207042118392 0.00446945311624272 0.00651360510942441 0.996796272025629 0.996054385346792 0.997429747626802 0.562189054726368 0.490628253143737 0.631888081644095 NA NA NA NA NA NA NA NA NA NA NA NA False True 1.69577046693238 1.27118261483609 2.26817886576511 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 88 62 13286 21251 0.00657993120981007 0.00528054396707009 0.00810046422834698 0.997090977337775 0.996272294271022 0.997768963796757 0.586666666666666 0.503468513376331 0.666371580410445 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 0 2.27026265824321 1.62051104166978 3.19710792036221 NA NA NA NA NA NA 9 5) Not assoc w R Now listed Silent mutation no 0 +Isoniazid katG c.729C>A katG_c.729C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.729C>T katG_c.729C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.439194051331254 0.00837049629364692 5.4704842261679 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.72T>G katG_c.72T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.735G>C katG_c.735G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.18865318395302 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.85651838973546 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.741C>T katG_c.741C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 3 16 20843 27452 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.99941750400466 0.999054234895718 0.999667017718464 0.157894736842105 0.0338262490017646 0.395784551266674 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.246953413616082 0.0461103487057789 0.862924537884952 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 3 14 13371 21299 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999343123914981 0.998898118907794 0.999640834680135 0.176470588235294 0.0379850680706259 0.434317872844283 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.341341068623994 0.0628905215833431 1.22336182693063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-76G>A katG_c.-76G>A 1 upstream_gene_variant 2156187 1 21 0 21 12 22 20834 27446 0.000575650004797083 0.000297481006307132 0.00100532857413147 0.999199068006407 0.998787628960307 0.999497994263003 0.352941176470588 0.197458647912342 0.535113629108957 0 0 0.161097615219079 0 0 0.154372512815574 0 0 0.253022332182273 7.69997751206872e-06 41 5574 True False 0.718563187796172 0.324032467749599 1.51679825795306 0 0 0.000177044873566246 0.999199068006407 0.998787628960307 0.999497994263003 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 18 0 18 5 18 13369 21295 0.000373859727830118 0.000121402023062639 0.000872246401868143 0.999155445033547 0.998665566208554 0.999499388823668 0.217391304347826 0.0746034076488037 0.437030726236814 0 0 0.185301968137852 0 0 0.185301968137852 0 0 0.362373734115458 0.000286820796359404 44 4479 True False 0 0 0 0 0 0 0 0.442462246823081 0.128385612384167 1.23693692462116 0 0 0.000275889787465637 0.999155445033547 0.998665566208554 0.999499388823668 6 3) Uncertain significance No change no 1 +Isoniazid katG c.-77T>C katG_c.-77T>C 1 upstream_gene_variant 2156188 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.780C>T katG_c.780C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-79C>T katG_c.-79C>T 1 upstream_gene_variant 2156190 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.-7G>A katG_c.-7G>A 1 upstream_gene_variant 2156118 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-7G>T katG_c.-7G>T 1 upstream_gene_variant 2156118 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3289 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2659 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-80T>G katG_c.-80T>G 1 upstream_gene_variant 2156191 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3199 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2590 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.816C>T katG_c.816C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 28 20845 27440 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.998980632008154 0.998527063823414 0.999322533833553 0.0344827586206896 0.000872646883579922 0.177644295488722 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.0470136723434876 0.00115408049364565 0.284421401182293 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 25 13373 21288 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.998827006991038 0.998268914575298 0.99924076142744 0.0384615384615384 0.00097328789333503 0.196369646762539 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.0636745681597248 0.00155499962861658 0.38908921072594 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.81A>G katG_c.81A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-81G>A katG_c.-81G>A 1 upstream_gene_variant 2156192 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3051 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-82T>C katG_c.-82T>C 1 upstream_gene_variant 2156193 0 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2986 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2431 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.831C>A katG_c.831C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.837C>A katG_c.837C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.840G>C katG_c.840G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.847C>T katG_c.847C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.84C>T katG_c.84C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-85_-81delCTATGinsT katG_c.-85_-81delCTATGinsT 1 upstream_gene_variant 2156192 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3302 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2673 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.858C>T katG_c.858C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-85C>T katG_c.-85C>T 1 upstream_gene_variant 2156196 1 618 23 595 753 628 20093 26840 0.0361220378010169 0.0336299296682003 0.0387445588924354 0.977137032182903 0.975299948921403 0.978872202504463 0.545257060101375 0.518559764477644 0.571761413139803 0.0372168284789644 0.0237358852723616 0.0553220504880388 0.0353302611367127 0.0225256809244013 0.0525428655785575 0.0516355250605692 0.0324613793728281 0.0782717996474223 8.08743282457149e-111 NA NA False True 1.60167006857602 1.43649028001567 1.78636562467385 0.00114336846291509 0.000724931256642816 0.00171512316814427 0.977137032182903 0.975299948921403 0.978872202504463 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 486 12 474 510 494 12864 20819 0.038133692238672 0.0349512974658553 0.0415190087528931 0.976821658142917 0.974711851120059 0.978799986400017 0.507968127490039 0.476561346172306 0.539328062549768 0.0246913580246913 0.0128220032333154 0.0427333379107959 0.0237154150197628 0.0123127665761361 0.0410593580931283 0.0409719598211474 0.0210422439544612 0.0722905736123722 2.69507816738072e-80 NA NA False True 0 1 1 0 0 1 1 1.67080998096561 1.47048976264086 1.89840397388524 0.000931966449207828 0.000481650445846711 0.00162739131917868 0.976821658142917 0.974711851120059 0.978799986400017 97 Not assoc w R 5) Not assoc w R No change yes 1 +Isoniazid katG c.-86T>G katG_c.-86T>G 1 upstream_gene_variant 2156197 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.87C>A katG_c.87C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 13 194 20833 27274 0.000623620838530173 0.000332092285535748 0.00106617452923529 0.992937236056502 0.991874740405958 0.993893348821595 0.0628019323671497 0.0338599692539895 0.10499901427533 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.0877280840617161 0.0458722096678989 0.153631390856156 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 10 183 13364 21130 0.000747719455660236 0.000358616922835118 0.00137465137870696 0.9914136911744 0.990082174996301 0.992608431155271 0.0518134715025906 0.0251230002457056 0.0932206287209583 NA NA NA NA NA NA NA NA NA NA NA NA False True 1 1 1 0 0 0 1 0.0863996414803329 0.0407520396760794 0.162621883876542 NA NA NA NA NA NA 32 5) Not assoc w R Now listed Silent mutation no 0 +Isoniazid katG c.87C>T katG_c.87C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.885G>A katG_c.885G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.894G>A katG_c.894G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-89G>A katG_c.-89G>A 1 upstream_gene_variant 2156200 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3320 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2685 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance No change no 1 +Isoniazid katG c.-89G>C katG_c.-89G>C 1 upstream_gene_variant 2156200 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3361 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2718 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-8G>A katG_c.-8G>A 1 upstream_gene_variant 2156119 1 2 2 0 3 1 20843 27467 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999963594000291 0.999797175631493 0.999999078280314 0.75 0.194120449683243 0.99369053679029 1 0.158113883008419 1 0.666666666666666 0.0942993240502461 0.991596241340387 Inf 0.247474761827698 Inf 0.18615809249565 394.5 5574 False False 3.95341361608213 0.31739219148065 207.323829234655 9.59462700887503e-05 1.16197496419179e-05 0.000346547484278011 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 3 1 13371 21312 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999953080279641 0.999738608085756 0.999998812096234 0.75 0.194120449683243 0.99369053679029 1 0.158113883008419 1 0.666666666666666 0.0942993240502461 0.991596241340387 Inf 0.299316108729698 Inf 0.148646379618986 208 4479 False False 0 0 0 0 0 0 0 4.78169172088849 0.383875689805931 250.696170545132 0.000149555073655873 1.81123264336181e-05 0.000540138824607934 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG c.-8G>C katG_c.-8G>C 1 upstream_gene_variant 2156119 2 1 0 1 4 1 20842 27467 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999963594000291 0.999797175631493 0.999999078280314 0.8 0.28358206388191 0.994949236620532 0 0 0.975 0 0 0.975 0 0 51.3582705287504 1 2027.5 5574 False False 5.27147106803569 0.521589398427432 259.279173455301 0 0 0.000176976922618654 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 0 1 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 62.1009148060541 1 1642.5 4479 False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 0 0 0.000275827900298067 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG c.915C>T katG_c.915C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-91T>C katG_c.-91T>C 1 upstream_gene_variant 2156202 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3338 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2701 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.924C>G katG_c.924C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-92C>A katG_c.-92C>A 1 upstream_gene_variant 2156203 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3063 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2487 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-92C>G katG_c.-92C>G 1 upstream_gene_variant 2156203 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3244 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-93A>C katG_c.-93A>C 1 upstream_gene_variant 2156204 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3395 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2747 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-93A>G katG_c.-93A>G 1 upstream_gene_variant 2156204 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3245 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG c.945C>T katG_c.945C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-95dupC katG_c.-95dupC 1 upstream_gene_variant 2156205 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2968 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2416 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.966G>A katG_c.966G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.869878292971449 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.966G>C katG_c.966G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.966G>T katG_c.966G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.972C>T katG_c.972C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.975G>A katG_c.975G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.981A>G katG_c.981A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 2 20844 27466 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999927188000582 0.999737003036386 0.999991182007438 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.3176933410094 0.0955278435529395 18.1762534351792 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.999C>T katG_c.999C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.99C>T katG_c.99C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG c.-99T>C katG_c.-99T>C 1 upstream_gene_variant 2156210 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3458 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2792 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.-9A>C katG_c.-9A>C 1 upstream_gene_variant 2156120 0 0 0 0 5 0 20841 27468 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 1 0.999865711673152 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 3200 5574 False False Inf 1.20760984683633 Inf 0 0 0.000176985413634466 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2591 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 4 3) Uncertain significance No change no 1 +Isoniazid katG c.-9A>T katG_c.-9A>T 1 upstream_gene_variant 2156120 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3095 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2514 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG c.9G>A katG_c.9G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid katG deletion katG_deletion 1 feature_ablation (see "Genomic_coordinates" sheet) 0 0 0 0 58 0 20788 27468 0.00278230835651923 0.00211338064309473 0.00359531342928037 1 0.999865711673152 1 1 0.93837899109608 1 NA NA NA NA NA NA NA NA NA NA 3027 5574 False False Inf 20.1151800584271 Inf 0 0 0.000177436606374299 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 41 0 13333 21313 0.00306564976820696 0.00220083411622644 0.00415662587679321 1 0.999826933785262 1 1 0.913956163705971 1 NA NA NA NA NA NA NA NA NA NA 2461 4479 False False 0 0 0 0 0 0 0 Inf 16.9759724663875 Inf 0 0 0.00027663460546986 1 0.999826933785262 1 5 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG LoF katG_LoF 1 LoF (see "Genomic_coordinates" sheet) 1 84 79 5 254 11 20592 27457 0.0121845917682049 0.0107396458301132 0.0137678552179872 0.999599534003203 0.9992835689522 0.999800072407065 0.958490566037736 0.926943297246181 0.979099384773437 0.94047619047619 0.866534267086032 0.980392421767844 0.877777777777777 0.791825795365399 0.937379390599158 21.0674339549339 8.65520433764808 66.6941915175929 1.81430435537899e-23 6 5574 True False 30.7890001412728 16.9117987319975 62.4572340298611 0.00382177930433941 0.0030268711808972 0.00476083420879901 0.999599534003203 0.9992835689522 0.999800072407065 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 60 56 4 176 9 13198 21304 0.0131598624196201 0.0112975983174946 0.0152381718197023 0.999577722516773 0.999198537836033 0.999806890245066 0.951351351351351 0.909661011316144 0.977516473755229 0.933333333333333 0.838013244802271 0.981538222424118 0.861538461538461 0.753361714678883 0.93468037599213 22.5985755417487 8.34787812435481 86.0347158729208 3.37626164076191e-19 6 4479 True False 0 0 0 0 0 0 0 31.5662642487919 16.2431589494044 70.1599275845588 0.00422513958050399 0.00319315608808643 0.00548323224183804 0.999577722516773 0.999198537836033 0.999806890245066 NA 1) Assoc w R High-level resistance UP from AwRI to AwR yes G 4 +Isoniazid katG p.Ala106Val katG_p.Ala106Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 7 0 20839 27468 0.000335795836131632 0.000135017659185429 0.000691744589626827 1 0.999865711673152 1 1 0.590383602774996 1 1 0.025 1 1 0.025 1 Inf 0.0337956847681309 Inf 0.431398526124037 604.5 5574 False False Inf 1.89951899263229 Inf 4.79846449136276e-05 1.21486528816812e-06 0.000267324007069132 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 0 13370 21313 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 1 0.999826933785262 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2627 4479 False False 0 0 0 0 0 0 0 Inf 1.05210128917758 Inf 0 0 0.000275869155324334 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala109Pro katG_p.Ala109Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3246 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2628 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala109Thr katG_p.Ala109Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 25 2 20821 27466 0.00119927084332725 0.000776250516059497 0.00176985477840228 0.999927188000582 0.999737003036386 0.999991182007438 0.925925925925926 0.757101653154372 0.990899927057693 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3303 5574 False False 16.4893617021276 4.11062542979143 143.567890655168 0 0 0.0001771554052158 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 12 1 13362 21312 0.000897263346792283 0.000463712283458933 0.00156681338714949 0.999953080279641 0.999738608085756 0.999998812096234 0.923076923076923 0.639702564732122 0.998054371502653 NA NA NA 0 0 0.975 NA NA NA NA 2674 4479 False False 0 0 0 0 0 0 0 19.1396497530309 2.83109378401325 815.077233909472 0 0 0.000276034298911909 0.999953080279641 0.999738608085756 0.999998812096234 2 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala109Val katG_p.Ala109Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 7 0 8 0 20838 27468 0.000383766669864722 0.000165697303700768 0.000756032532322191 1 0.999865711673152 1 1 0.63058335244718 1 1 0.590383602774996 1 1 0.590383602774996 1 Inf 1.89961010411293 Inf 0.0027817395621241 91.5 5574 False False Inf 2.24970730189478 Inf 0.000335811945310626 0.000135024136900867 0.000691777768874454 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 7 0 8 0 13366 21313 0.000598175564528189 0.000258283997825234 0.00117830226263269 1 0.999826933785262 1 1 0.63058335244718 1 1 0.590383602774996 1 1 0.590383602774996 1 Inf 2.29772549841427 Inf 0.00126503700734508 56 4479 False False 0 0 0 0 0 0 0 Inf 2.72130996382454 Inf 0.000523442757795558 0.000210476208336433 0.00107819284954331 1 0.999826933785262 1 NA 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Ala110Pro katG_p.Ala110Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Ala110Thr katG_p.Ala110Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 3 2 20843 27466 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999927188000582 0.999737003036386 0.999991182007438 0.6 0.146632799634673 0.947255049473683 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01699856622015 0.509392482788101 1176.5 5574 False False 1.97663484143357 0.226402568392661 23.6672561646805 0 0 0.00017696843241753 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2824 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala110Val katG_p.Ala110Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 14 0 20832 27468 0.000671591672263264 0.000367212509754494 0.00112656023057506 1 0.999865711673152 1 1 0.768364238349883 1 1 0.025 1 1 0.025 1 Inf 0.0338070404874895 Inf 0.431316121819424 595 5574 False False Inf 4.37287801662981 Inf 4.80007680122881e-05 1.21527348918813e-06 0.000267413819517412 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 11 0 13363 21313 0.000822491401226259 0.000410653977896139 0.00147118664271154 1 0.999826933785262 1 1 0.715085847081845 1 1 0.025 1 1 0.025 1 Inf 0.0408922660640232 Inf 0.385385125587565 475 4479 False False 0 0 0 0 0 0 0 Inf 4.00162721599209 Inf 7.4827895839569e-05 1.89447650421177e-06 0.000416843047927529 1 0.999826933785262 1 2 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala122Asp katG_p.Ala122Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala122Pro katG_p.Ala122Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Ala122Thr katG_p.Ala122Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3428 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2770 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Ala130Glu katG_p.Ala130Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2969 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Ala130Thr katG_p.Ala130Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2970 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2417 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Ala139Pro katG_p.Ala139Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3396 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2748 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala139Thr katG_p.Ala139Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala144Thr katG_p.Ala144Thr 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2462 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 2 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Ala144Val katG_p.Ala144Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.31774131644597 0.016793557463775 103.362071688999 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.59377804367334 0.0203020758039404 124.993150249237 1 1642.5 4479 False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 7.47775368279368e-05 1.89320152683959e-06 0.000416562561410248 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala15Val katG_p.Ala15Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala162Glu katG_p.Ala162Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3096 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2515 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala162Gly katG_p.Ala162Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala162Thr katG_p.Ala162Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2488 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala162Val katG_p.Ala162Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 1 3 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.439194051331254 0.00837049629364692 5.4704842261679 0.638942720978879 1228.5 5574 False False 0.439194051331254 0.00837049629364692 5.4704842261679 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala168Thr katG_p.Ala168Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3510 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2825 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala168Val katG_p.Ala168Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Ala16fs katG_p.Ala16fs 1 frameshift (see "Genomic_coordinates" sheet) 1 4 3 1 5 2 20841 27466 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.999927188000582 0.999737003036386 0.999991182007438 0.714285714285714 0.290420863737342 0.963307433823914 0.75 0.194120449683243 0.99369053679029 0.6 0.146632799634673 0.947255049473683 3.95364905714697 0.317411094784331 207.336160967293 0.321774940087971 580 5574 False False 3.29470754762247 0.539313466840718 34.60579842565 0.000143926309729418 2.9682048729561e-05 0.000420555567348889 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 3 1 3 1 13371 21312 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999953080279641 0.999738608085756 0.999998812096234 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 4.78169172088849 0.383875689805931 250.696170545132 0.162956956196593 228 4479 False False 0 0 0 0 0 0 0 4.78169172088849 0.383875689805931 250.696170545132 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999953080279641 0.999738608085756 0.999998812096234 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change AwRI by relaxed thresholds (not endorsed) no G, O 1 +Isoniazid katG p.Ala172Thr katG_p.Ala172Thr 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala172Val katG_p.Ala172Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.24749564543886 Inf 0.186140231321028 382.5 5574 False False Inf 0.869878292971449 Inf 9.59508731529456e-05 1.16203071146137e-05 0.000346564107961184 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.299330161198724 Inf 0.148637808646281 204 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0.000149555073655873 1.81123264336181e-05 0.000540138824607934 1 0.999826933785262 1 1 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Ala202fs katG_p.Ala202fs 1 frameshift (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Ala202Ser katG_p.Ala202Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala222Thr katG_p.Ala222Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3492 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2814 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala243Thr katG_p.Ala243Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 51.3533466119536 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 62.1009148060541 1 1642.5 4479 False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 0 0 0.000275827900298067 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala244Gly katG_p.Ala244Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 3 2 20843 27466 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999927188000582 0.999737003036386 0.999991182007438 0.6 0.146632799634673 0.947255049473683 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01699856622015 0.509392482788101 1176.5 5574 False False 1.97663484143357 0.226402568392661 23.6672561646805 0 0 0.00017696843241753 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 1 13371 21312 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999953080279641 0.999738608085756 0.999998812096234 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 62.1055547471297 1 1642.5 4479 False False 0 0 0 0 0 0 0 4.78169172088849 0.383875689805931 250.696170545132 0 0 0.000275848526268708 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala256Gly katG_p.Ala256Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 3321 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 2686 4479 False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 0 0 0.000275827900298067 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala256Thr katG_p.Ala256Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3220 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2608 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala256Val katG_p.Ala256Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3160 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2563 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala263Pro katG_p.Ala263Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3028 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala264Thr katG_p.Ala264Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3261 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2637 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Ala264Val katG_p.Ala264Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 6 2 20840 27466 0.000287825002398541 0.000105633792978048 0.000626367784710498 0.999927188000582 0.999737003036386 0.999991182007438 0.75 0.349144205587175 0.968145973750055 0 0 0.975 0 0 0.841886116991581 0 0 51.3613269620582 1 2027.5 5574 False False 3.95383877159309 0.706870204411237 40.0621427029589 0 0 0.000176993905465082 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2815 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala281Thr katG_p.Ala281Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala290Pro katG_p.Ala290Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2987 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2432 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala291Asp katG_p.Ala291Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala312Pro katG_p.Ala312Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.31767810026385 0.0167927522337569 103.35711725526 1 1253.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala348Gly katG_p.Ala348Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala359_Gly362del katG_p.Ala359_Gly362del 1 inframe_deletion (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3459 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Isoniazid katG p.Ala379Thr katG_p.Ala379Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3362 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2719 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala379Val katG_p.Ala379Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 10 2 20836 27466 0.000479708337330902 0.000230061997553563 0.000882023176671562 0.999927188000582 0.999737003036386 0.999991182007438 0.833333333333333 0.515862251314033 0.979137474539907 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3290 5574 False False 6.59099635246688 1.40433109003891 61.9123962243262 0 0 0.000177027880937939 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 9 0 13365 21313 0.000672947510094212 0.000307759154923187 0.00127707788784856 1 0.999826933785262 1 1 0.663732883120057 1 NA NA NA NA NA NA NA NA NA NA 2660 4479 False False 0 0 0 0 0 0 0 Inf 3.14671336895126 Inf 0 0 0.000275972346901473 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala411Asp katG_p.Ala411Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 1 0.025 1 1 0.025 1 Inf 0.0337891992100405 Inf 0.431445603576751 617.5 5574 False False Inf 0.544526627735454 Inf 4.79754365764728e-05 1.21463215353938e-06 0.000267272712750976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2661 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala424Gly katG_p.Ala424Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3304 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2675 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala424Val katG_p.Ala424Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala476Gly katG_p.Ala476Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3143 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2548 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Ala476Val katG_p.Ala476Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 2 2 2 2 20844 27466 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999927188000582 0.999737003036386 0.999991182007438 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 1.3176933410094 0.0955278435529395 18.1762534351792 1 2027.5 5574 False False 1.3176933410094 0.0955278435529395 18.1762534351792 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Ala478fs katG_p.Ala478fs 1 frameshift (see "Genomic_coordinates" sheet) 2 1 1 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0337875782094303 Inf 0.431457371721896 645 5574 False False Inf 0.247471899512553 Inf 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2549 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Ala479Glu katG_p.Ala479Glu 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala479Gly katG_p.Ala479Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3275 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2647 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala479Val katG_p.Ala479Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3511 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala480del katG_p.Ala480del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 2 1 1 5 1 20841 27467 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.999963594000291 0.999797175631493 0.999999078280314 0.833333333333333 0.358765421002325 0.99578925548551 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.31793100139148 0.0167959736174585 103.376937840414 1 2027.5 5574 False False 6.58965500695744 0.737267067818355 311.215258952954 4.79800403032338e-05 1.21474870966795e-06 0.000267298357449221 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 5 1 13369 21312 0.000373859727830118 0.000121402023062639 0.000872246401868143 0.999953080279641 0.999738608085756 0.999998812096234 0.833333333333333 0.358765421002325 0.99578925548551 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.59413568703717 0.0203066313158993 125.021169671472 1 1642.5 4479 False False 0 0 0 0 0 0 0 7.97067843518587 0.891722638077622 376.304140424995 7.47943156320119e-05 1.89362632857505e-06 0.000416656014965588 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Isoniazid katG p.Ala480dup katG_p.Ala480dup 1 inframe_insertion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Isoniazid katG p.Ala480Gln katG_p.Ala480Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3291 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2662 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala480Ser katG_p.Ala480Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 7 3 20839 27465 0.000335795836131632 0.000135017659185429 0.000691744589626827 0.999890782000873 0.99968085216583 0.999977476056514 0.7 0.347547149940002 0.933260488822265 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18972436041205 0.264108098295479 572.5 5574 False False 3.07524353375881 0.70193019624619 18.4306658389899 0 0 0.00017700239811062 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 7 3 13367 21310 0.000523403618962165 0.000210460468745924 0.00107811225334149 0.999859240838924 0.999588697652472 0.999970971136275 0.7 0.347547149940002 0.933260488822265 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85853834573469 0.289352662595783 412 4479 False False 0 0 0 0 0 0 0 3.71985736016558 0.848991347451885 22.2950894269216 0 0 0.000275931061008045 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala492Asp katG_p.Ala492Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0337875782094303 Inf 0.431457371721896 645 5574 False False Inf 0.247471899512553 Inf 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.040864745349235 Inf 0.385544600126852 512 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 7.47775368279368e-05 1.89320152683959e-06 0.000416562561410248 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala492Val katG_p.Ala492Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3247 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2629 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Ala531Ser katG_p.Ala531Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2971 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2418 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Ala532Pro katG_p.Ala532Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3429 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2771 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala53Thr katG_p.Ala53Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala541Thr katG_p.Ala541Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 7.01606985634675 0.509383580255417 1109.5 5574 False False 0.439194051331254 0.00837049629364692 5.4704842261679 0 0 0.000176951454458875 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala541Val katG_p.Ala541Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3474 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2804 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala550Pro katG_p.Ala550Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Ala550Thr katG_p.Ala550Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Ala551fs katG_p.Ala551fs 1 frameshift (see "Genomic_coordinates" sheet) 2 1 1 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0337875782094303 Inf 0.431457371721896 645 5574 False False Inf 0.247471899512553 Inf 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.040864745349235 Inf 0.385544600126852 512 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 7.47775368279368e-05 1.89320152683959e-06 0.000416562561410248 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Ala551Gly katG_p.Ala551Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3097 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2516 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Ala555Pro katG_p.Ala555Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Ala556Glu katG_p.Ala556Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3378 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2732 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Ala558Arg katG_p.Ala558Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3349 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2709 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 4 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala559fs katG_p.Ala559fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3064 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Ala559Val katG_p.Ala559Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala574Val katG_p.Ala574Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Ala585fs katG_p.Ala585fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3512 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2826 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Ala591Thr katG_p.Ala591Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18880616510555 0.264079043314886 541.5 5574 False False 0.439194051331254 0.00837049629364692 5.4704842261679 0 0 0.000176951454458875 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48598624162872 0.526186417038858 925 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala606Pro katG_p.Ala606Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 20846 27462 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.11900921779861 0.0402109359097128 194.5 5574 False False 0 0 1.11900921779861 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 13374 21307 0 0 0.000275786657608973 0.999718481677849 0.999387354605726 0.999896680954833 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.35335561005417 0.0884814409570568 164 4479 False False 0 0 0 0 0 0 0 0 0 1.35335561005417 0 0 0.000275786657608973 0.999718481677849 0.999387354605726 0.999896680954833 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala606Thr katG_p.Ala606Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 1 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala60Gly katG_p.Ala60Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala60Thr katG_p.Ala60Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Ala60Val katG_p.Ala60Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala614Glu katG_p.Ala614Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala614Thr katG_p.Ala614Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 4 2 20842 27466 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999927188000582 0.999737003036386 0.999991182007438 0.666666666666666 0.222778095503512 0.956728131707258 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01733524879011 0.509395710775307 1192 5574 False False 2.63563957393724 0.377684835565828 29.1411399702847 0 0 0.000176976922618654 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48598624162872 0.526186417038858 925 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala61Pro katG_p.Ala61Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3114 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala61Ser katG_p.Ala61Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala621Asp katG_p.Ala621Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0337875782094303 Inf 0.431457371721896 645 5574 False False Inf 0.247471899512553 Inf 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2463 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Ala621Gly katG_p.Ala621Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2972 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2419 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Ala621Thr katG_p.Ala621Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3065 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2489 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala649Thr katG_p.Ala649Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 51.3533466119536 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2481 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala706Thr katG_p.Ala706Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3029 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala713Pro katG_p.Ala713Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3430 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala716Gly katG_p.Ala716Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3221 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2609 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Ala716Thr katG_p.Ala716Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala726Thr katG_p.Ala726Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 5 4 20841 27464 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.999854376001165 0.999627187086024 0.999960320981843 0.555555555555555 0.212008506778868 0.863004337734833 0 0 0.602364635616474 0 0 0.602364635616474 0 0 1.99652637191527 0.139142388186343 355 5574 False False 1.64723381795499 0.354499279020611 8.30243796120459 0 0 0.000176985413634466 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala727Thr katG_p.Ala727Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3339 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2702 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala75Val katG_p.Ala75Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3161 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2564 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ala93Asp katG_p.Ala93Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0337875782094303 Inf 0.431457371721896 645 5574 False False Inf 0.247471899512553 Inf 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.040864745349235 Inf 0.385544600126852 512 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 7.47775368279368e-05 1.89320152683959e-06 0.000416562561410248 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Arg104Gln katG_p.Arg104Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 2 1 3 1 20843 27467 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999963594000291 0.999797175631493 0.999999078280314 0.75 0.194120449683243 0.99369053679029 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 2.63560907738809 0.13718999164004 155.35696976537 0.581595476863033 1223 5574 False False 3.95341361608213 0.31739219148065 207.323829234655 9.59462700887503e-05 1.16197496419179e-05 0.000346547484278011 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 2 1 3 1 13371 21312 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999953080279641 0.999738608085756 0.999998812096234 0.75 0.194120449683243 0.99369053679029 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 3.18779448059232 0.165928500256239 187.866738622227 0.563289337443726 991 4479 False False 0 0 0 0 0 0 0 4.78169172088849 0.383875689805931 250.696170545132 0.000149555073655873 1.81123264336181e-05 0.000540138824607934 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Arg104Leu katG_p.Arg104Leu 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Arg104Pro katG_p.Arg104Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3363 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Arg104Trp katG_p.Arg104Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Arg128Gln katG_p.Arg128Gln 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3513 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2827 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Arg128Gly katG_p.Arg128Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3222 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2610 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Arg128Trp katG_p.Arg128Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.247471899512553 Inf 0.186160540855956 404 5574 False False Inf 0.247471899512553 Inf 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.299307766452077 Inf 0.148651468333857 217.5 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain AwRI by relaxed thresholds (not endorsed) yes O 0 +Isoniazid katG p.Arg145Cys katG_p.Arg145Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 3 1 20843 27467 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999963594000291 0.999797175631493 0.999999078280314 0.75 0.194120449683243 0.99369053679029 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.31780453869404 0.0167943627710572 103.367026597726 1 1253.5 5574 False False 3.95341361608213 0.31739219148065 207.323829234655 4.79754365764728e-05 1.21463215353938e-06 0.000267272712750976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.59377804367334 0.0203020758039404 124.993150249237 1 1642.5 4479 False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 7.47775368279368e-05 1.89320152683959e-06 0.000416562561410248 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Arg145His katG_p.Arg145His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3305 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Arg145Pro katG_p.Arg145Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 1 0.025 1 1 0.025 1 Inf 0.0337891992100405 Inf 0.431445603576751 617.5 5574 False False Inf 0.544526627735454 Inf 4.79754365764728e-05 1.21463215353938e-06 0.000267272712750976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2528 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Arg146Gln katG_p.Arg146Gln 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3162 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2565 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Arg146Gly katG_p.Arg146Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.247471899512553 Inf 0.186160540855956 404 5574 False False Inf 0.247471899512553 Inf 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Arg146Leu katG_p.Arg146Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3306 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2676 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Arg187Trp katG_p.Arg187Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Arg249Cys katG_p.Arg249Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0337847273324512 Inf 0.431478070084656 825 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0408597725378736 Inf 0.385573430202387 666 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Arg249Gly katG_p.Arg249Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 3) Uncertain significance No change no 1 +Isoniazid katG p.Arg249His katG_p.Arg249His 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.31767810026385 0.0167927522337569 103.35711725526 1 1253.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Arg249Leu katG_p.Arg249Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3179 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Arg249Pro katG_p.Arg249Pro 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Arg249Ser katG_p.Arg249Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0.5 0.012579117093425 0.987420882906574 0.333333333333333 0.00840375865961264 0.905700675949754 1.3176301271288 0.0167921411364289 103.353357597319 1 1253.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Arg253Pro katG_p.Arg253Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3126 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Arg254His katG_p.Arg254His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3007 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2447 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Arg254Ser katG_p.Arg254Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3248 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2630 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Arg395Leu katG_p.Arg395Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3030 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2464 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Arg425Gly katG_p.Arg425Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3276 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Arg463Leu katG_p.Arg463Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 7356 327 7029 12002 12830 8844 14638 0.575745946464549 0.569002669222259 0.582468092072869 0.532911023736711 0.526989468132649 0.538825615675733 0.483327963917525 0.47709466229882 0.489565168426747 0.0444535073409461 0.0398570774075854 0.0494151553969857 0.0248536900509234 0.022261084018609 0.0276592512354829 0.0769993782301004 0.0684904119084064 0.0863000643728859 0 NA NA False True 1.54831733065699 1.49283716099112 1.60586106001399 0.0356558717697088 0.0319543951994994 0.0396559310775759 0.532911023736711 0.526989468132649 0.538825615675733 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 5202 216 4986 7507 9704 5867 11609 0.561312995364139 0.552853000226089 0.569746299322557 0.544691033641439 0.537976048423432 0.55139382517128 0.436174539538667 0.428748003444591 0.443622651867944 0.0415224913494809 0.0362638754830248 0.047303021528163 0.021774193548387 0.0189928752077556 0.024840962381481 0.0857196126655914 0.0741698373316114 0.0986131444192759 0 NA NA False True 0 1 1 0 0 1 1 1.53071504570044 1.46513888681669 1.59925155919559 0.0355087950024658 0.0309999520692007 0.0404698041130576 0.544691033641439 0.537976048423432 0.55139382517128 2599 Not assoc w R Not assoc w R 5) Not assoc w R No change yes 1 +Isoniazid katG p.Arg463Trp katG_p.Arg463Trp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3066 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2490 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Arg484His katG_p.Arg484His 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 3 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.544526627735454 Inf 0.0803181469117723 287 5574 False False Inf 0.544526627735454 Inf 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Arg489Cys katG_p.Arg489Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 51.3533466119536 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Arg489Ser katG_p.Arg489Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3127 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Arg496fs katG_p.Arg496fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Arg496His katG_p.Arg496His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Arg496Leu katG_p.Arg496Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Arg498Cys katG_p.Arg498Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Arg498His katG_p.Arg498His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3364 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2720 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Arg498Leu katG_p.Arg498Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0337875782094303 Inf 0.431457371721896 645 5574 False False Inf 0.247471899512553 Inf 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.040864745349235 Inf 0.385544600126852 512 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 7.47775368279368e-05 1.89320152683959e-06 0.000416562561410248 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Arg498Ser katG_p.Arg498Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Arg515His katG_p.Arg515His 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Arg519His katG_p.Arg519His 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3322 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2687 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Arg571Gly katG_p.Arg571Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Arg571His katG_p.Arg571His 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 2 1 3 1 20843 27467 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999963594000291 0.999797175631493 0.999999078280314 0.75 0.194120449683243 0.99369053679029 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 2.63560907738809 0.13718999164004 155.35696976537 0.581595476863033 1223 5574 False False 3.95341361608213 0.31739219148065 207.323829234655 9.59462700887503e-05 1.16197496419179e-05 0.000346547484278011 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.299307766452077 Inf 0.148651468333857 217.5 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 NA 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Arg571Leu katG_p.Arg571Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3493 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Arg595Gln katG_p.Arg595Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Arg595Leu katG_p.Arg595Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3163 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Arg632Cys katG_p.Arg632Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3292 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2663 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Arg693His katG_p.Arg693His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2944 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2396 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Arg705Leu katG_p.Arg705Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Arg705Trp katG_p.Arg705Trp 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Arg736Lys katG_p.Arg736Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance No change no 1 +Isoniazid katG p.Arg736Ser katG_p.Arg736Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Arg78Pro katG_p.Arg78Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3431 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Asn133_Glu233delinsLys katG_p.Asn133_Glu233delinsLys 1 inframe_deletion (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3307 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Isoniazid katG p.Asn133Ser katG_p.Asn133Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3514 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2828 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Asn133Thr katG_p.Asn133Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3432 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2772 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Asn138Asp katG_p.Asn138Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 4 2 6 2 20840 27466 0.000287825002398541 0.000105633792978048 0.000626367784710498 0.999927188000582 0.999737003036386 0.999991182007438 0.75 0.349144205587175 0.968145973750055 0.666666666666666 0.222778095503512 0.956728131707258 0.666666666666666 0.222778095503512 0.956728131707258 2.63589251439539 0.377721076122186 29.1439330670829 0.413001051294261 587 5574 False False 3.95383877159309 0.706870204411237 40.0621427029589 0.000191901746305891 5.22891630665053e-05 0.000491271127280021 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 4 2 5 2 13369 21311 0.000373859727830118 0.000121402023062639 0.000872246401868143 0.999906160559283 0.999661061221376 0.999988635406343 0.714285714285714 0.290420863737342 0.963307433823914 0.666666666666666 0.222778095503512 0.956728131707258 0.666666666666666 0.222778095503512 0.956728131707258 3.18812177425387 0.456809764795222 35.2496246543756 0.213608237291857 274 4479 False False 0 0 0 0 0 0 0 3.98515221781733 0.652287032938702 41.8973624237223 0.000299110147311747 8.15032691820268e-05 0.000765662069545588 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Asn138His katG_p.Asn138His 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 7 0 20839 27468 0.000335795836131632 0.000135017659185429 0.000691744589626827 1 0.999865711673152 1 1 0.590383602774996 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.247531272873912 Inf 0.18610976594322 378 5574 False False Inf 1.89951899263229 Inf 9.59646849959215e-05 1.16219798536933e-05 0.000346613988581222 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 6 0 13368 21313 0.000448631673396141 0.000164657143425453 0.000976224581517196 1 0.999826933785262 1 1 0.540741873560099 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.299397365529957 Inf 0.148596828623885 198.5 4479 False False 0 0 0 0 0 0 0 Inf 1.87681913692541 Inf 0.000149588631264023 1.8116390645981e-05 0.00054025999886845 1 0.999826933785262 1 1 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Asn138Ser katG_p.Asn138Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 7 0 8 0 20838 27468 0.000383766669864722 0.000165697303700768 0.000756032532322191 1 0.999865711673152 1 1 0.63058335244718 1 1 0.590383602774996 1 1 0.590383602774996 1 Inf 1.89961010411293 Inf 0.0027817395621241 91.5 5574 False False Inf 2.24970730189478 Inf 0.000335811945310626 0.000135024136900867 0.000691777768874454 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 7 0 7 0 13367 21313 0.000523403618962165 0.000210460468745924 0.00107811225334149 1 0.999826933785262 1 1 0.590383602774996 1 1 0.590383602774996 1 1 0.590383602774996 1 Inf 2.29755378883993 Inf 0.00126544405491573 57 4479 False False 0 0 0 0 0 0 0 Inf 2.29755378883993 Inf 0.000523403618962165 0.000210460468745924 0.00107811225334149 1 0.999826933785262 1 1 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Asn170Lys katG_p.Asn170Lys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 7 0 20839 27468 0.000335795836131632 0.000135017659185429 0.000691744589626827 1 0.999865711673152 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 3249 5574 False False Inf 1.89951899263229 Inf 0 0 0.00017700239811062 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 7 0 13367 21313 0.000523403618962165 0.000210460468745924 0.00107811225334149 1 0.999826933785262 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 2631 4479 False False 0 0 0 0 0 0 0 Inf 2.29755378883993 Inf 0 0 0.000275931061008045 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Asn18fs katG_p.Asn18fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3293 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2664 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Asn236fs katG_p.Asn236fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3277 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2648 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Asn236Lys katG_p.Asn236Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Asn238Thr katG_p.Asn238Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3144 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Asn323Ser katG_p.Asn323Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Asn35fs katG_p.Asn35fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2973 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2420 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Asn35His katG_p.Asn35His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Asn35Thr katG_p.Asn35Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3201 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Asn493Gly katG_p.Asn493Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3365 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2721 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Asn493His katG_p.Asn493His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3052 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2482 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Asn493Lys katG_p.Asn493Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 2 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 2.63548263289195 0.137183409715989 155.34952410964 0.581601386260749 1225.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Asn493Ser katG_p.Asn493Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 5 0 20841 27468 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 1 0.999865711673152 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 3323 5574 False False Inf 1.20760984683633 Inf 0 0 0.000176985413634466 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 5 0 13369 21313 0.000373859727830118 0.000121402023062639 0.000872246401868143 1 0.999826933785262 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 2688 4479 False False 0 0 0 0 0 0 0 Inf 1.46057233596553 Inf 0 0 0.000275889787465637 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Asn508Asp katG_p.Asn508Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3475 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2805 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Asn51fs katG_p.Asn51fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0337847273324512 Inf 0.431478070084656 825 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2538 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Asn51Thr katG_p.Asn51Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3067 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2491 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Asn529His katG_p.Asn529His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3202 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2592 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Asn529Thr katG_p.Asn529Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 4 2 20842 27466 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999927188000582 0.999737003036386 0.999991182007438 0.666666666666666 0.222778095503512 0.956728131707258 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01733524879011 0.509395710775307 1192 5574 False False 2.63563957393724 0.377684835565828 29.1411399702847 0 0 0.000176976922618654 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 3 2 13371 21311 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999906160559283 0.999661061221376 0.999988635406343 0.6 0.146632799634673 0.947255049473683 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.4872555868813 0.526202640597156 962.5 4479 False False 0 0 0 0 0 0 0 2.39073367736145 0.273835790357664 28.6284716983702 0 0 0.000275848526268708 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Asn535fs katG_p.Asn535fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3164 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2566 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Asn535Thr katG_p.Asn535Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Asn562His katG_p.Asn562His 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 2 9 20844 27459 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999672346002621 0.99937810218515 0.999850165132458 0.181818181818181 0.0228311982999596 0.517755852360172 0 0 0.369416647552819 0 0 0.336267116879942 0 0 0.771854506059491 0.0121125680946169 129.5 5574 False False 0.292746113989637 0.0307804028975754 1.41460768720699 0 0 0.000176959943030976 0.999672346002621 0.99937810218515 0.999850165132458 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 1 6 13373 21307 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999718481677849 0.999387354605726 0.999896680954833 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.35345678111722 0.0884835334370246 175 4479 False False 0 0 0 0 0 0 0 0.265547496198808 0.00577686092206708 2.18912593855065 0 0 0.000275807277411719 0.999718481677849 0.999387354605726 0.999896680954833 3 3) Uncertain significance No change no 1 +Isoniazid katG p.Asn596Lys katG_p.Asn596Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Asn596Ser katG_p.Asn596Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 5 0 20841 27468 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 1 0.999865711673152 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 3031 5574 False False Inf 1.20760984683633 Inf 0 0 0.000176985413634466 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 5 0 13369 21313 0.000373859727830118 0.000121402023062639 0.000872246401868143 1 0.999826933785262 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 2465 4479 False False 0 0 0 0 0 0 0 Inf 1.46057233596553 Inf 0 0 0.000275889787465637 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Asn596Thr katG_p.Asn596Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0337863481185338 Inf 0.431466302367941 667 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2567 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Asn637Lys katG_p.Asn637Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.247471899512553 Inf 0.186160540855956 404 5574 False False Inf 0.247471899512553 Inf 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Asn637Tyr katG_p.Asn637Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Asn655Asp katG_p.Asn655Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3083 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2505 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Asn660Ala katG_p.Asn660Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Asn660Asp katG_p.Asn660Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 1 20843 27467 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999963594000291 0.999797175631493 0.999999078280314 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 51.3558084523276 1 2027.5 5574 False False 3.95341361608213 0.31739219148065 207.323829234655 0 0 0.00017696843241753 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2649 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Asn660His katG_p.Asn660His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0337875782094303 Inf 0.431457371721896 645 5574 False False Inf 0.247471899512553 Inf 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.040864745349235 Inf 0.385544600126852 512 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 7.47775368279368e-05 1.89320152683959e-06 0.000416562561410248 1 0.999826933785262 1 1 3) Uncertain significance No change no 1 +Isoniazid katG p.Asp142Ala katG_p.Asp142Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3165 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2568 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Asp142Asn katG_p.Asp142Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 5 0 20841 27468 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 1 0.999865711673152 1 1 0.478176249895018 1 1 0.025 1 1 0.025 1 Inf 0.033792441677911 Inf 0.43142206582488 609.5 5574 False False Inf 1.20760984683633 Inf 4.79800403032338e-05 1.21474870966795e-06 0.000267298357449221 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 1 0.025 1 1 0.025 1 Inf 0.0408678013770354 Inf 0.385526884820527 489.5 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 7.47831289261142e-05 1.89334310623943e-06 0.000416593707936992 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Asp142Cys katG_p.Asp142Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3433 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2773 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Asp142Gly katG_p.Asp142Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 7 1 10 2 20836 27466 0.000479708337330902 0.000230061997553563 0.000882023176671562 0.999927188000582 0.999737003036386 0.999991182007438 0.833333333333333 0.515862251314033 0.979137474539907 0.875 0.473490329124793 0.996840276468748 0.777777777777777 0.399906426283687 0.971855026522101 9.22739489345364 1.18526527810447 415.07389231171 0.0247655730654005 171 5574 False False 6.59099635246688 1.40433109003891 61.9123962243262 0.000335844168305906 0.0001350370941966 0.000691844136919199 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 4 1 5 2 13369 21311 0.000373859727830118 0.000121402023062639 0.000872246401868143 0.999906160559283 0.999661061221376 0.999988635406343 0.714285714285714 0.290420863737342 0.963307433823914 0.8 0.28358206388191 0.994949236620532 0.666666666666666 0.222778095503512 0.956728131707258 6.37624354850774 0.630864135956984 313.522104578498 0.0763943857510731 149 4479 False False 0 0 0 0 0 0 0 3.98515221781733 0.652287032938702 41.8973624237223 0.000299110147311747 8.15032691820268e-05 0.000765662069545588 0.999906160559283 0.999661061221376 0.999988635406343 1 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Asp163Asn katG_p.Asp163Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0337875782094303 Inf 0.431457371721896 645 5574 False False Inf 0.247471899512553 Inf 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Asp163fs katG_p.Asp163fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2974 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2421 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Asp163Glu katG_p.Asp163Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Asp189Ala katG_p.Asp189Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.247471899512553 Inf 0.186160540855956 404 5574 False False Inf 0.247471899512553 Inf 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Asp189Asn katG_p.Asp189Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.24748377190611 Inf 0.186150386160192 389.5 5574 False False Inf 0.544526627735454 Inf 9.59462700887503e-05 1.16197496419179e-05 0.000346547484278011 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Asp189Gly katG_p.Asp189Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 4 2 8 2 20838 27466 0.000383766669864722 0.000165697303700768 0.000756032532322191 0.999927188000582 0.999737003036386 0.999991182007438 0.8 0.443904537692358 0.974789273673166 0.666666666666666 0.222778095503512 0.956728131707258 0.666666666666666 0.222778095503512 0.956728131707258 2.63614550340723 0.37775732363786 29.1467267034656 0.412996223153126 586 5574 False False 5.27229100681447 1.05199089761157 50.9538747369096 0.000191920161212935 5.22941809687646e-05 0.000491318262637833 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 5 1 13369 21312 0.000373859727830118 0.000121402023062639 0.000872246401868143 0.999953080279641 0.999738608085756 0.999998812096234 0.833333333333333 0.358765421002325 0.99578925548551 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.59413568703717 0.0203066313158993 125.021169671472 1 1642.5 4479 False False 0 0 0 0 0 0 0 7.97067843518587 0.891722638077622 376.304140424995 7.47943156320119e-05 1.89362632857505e-06 0.000416656014965588 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Asp189Tyr katG_p.Asp189Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Asp194Asn katG_p.Asp194Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01632529799099 0.509386028876591 1135.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48598624162872 0.526186417038858 925 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Asp207Asn katG_p.Asp207Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3128 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Asp215Glu katG_p.Asp215Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Asp240Ala katG_p.Asp240Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3129 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2539 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Asp240Asn katG_p.Asp240Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Asp240fs katG_p.Asp240fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3397 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2749 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Asp247His katG_p.Asp247His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3515 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2829 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Asp259Ala katG_p.Asp259Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Asp259Glu katG_p.Asp259Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3398 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2750 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Asp282Gly katG_p.Asp282Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Asp311Gly katG_p.Asp311Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.24748377190611 Inf 0.186150386160192 389.5 5574 False False Inf 0.544526627735454 Inf 9.59462700887503e-05 1.16197496419179e-05 0.000346547484278011 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2397 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Asp329Ala katG_p.Asp329Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3494 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Asp329fs katG_p.Asp329fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3068 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2492 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Asp357His katG_p.Asp357His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3379 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2733 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Asp37Asn katG_p.Asp37Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3399 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Isoniazid katG p.Asp37Glu katG_p.Asp37Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Asp37Gly katG_p.Asp37Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3032 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2466 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Asp381Ala katG_p.Asp381Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.247471899512553 Inf 0.186160540855956 404 5574 False False Inf 0.247471899512553 Inf 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.299307766452077 Inf 0.148651468333857 217.5 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain AwRI by relaxed thresholds (not endorsed) yes O 0 +Isoniazid katG p.Asp381Asn katG_p.Asp381Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Asp381fs katG_p.Asp381fs 1 frameshift (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Asp381Gly katG_p.Asp381Gly 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Asp381His katG_p.Asp381His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3400 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2751 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Asp387Gly katG_p.Asp387Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Asp387His katG_p.Asp387His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2945 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Asp406Ala katG_p.Asp406Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Asp406Gly katG_p.Asp406Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Asp419Ala katG_p.Asp419Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3366 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Asp419Gly katG_p.Asp419Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3098 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Asp419His katG_p.Asp419His 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.24749564543886 Inf 0.186140231321028 382.5 5574 False False Inf 0.869878292971449 Inf 9.59508731529456e-05 1.16203071146137e-05 0.000346564107961184 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.299330161198724 Inf 0.148637808646281 204 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0.000149555073655873 1.81123264336181e-05 0.000540138824607934 1 0.999826933785262 1 1 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Asp419Tyr katG_p.Asp419Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 6 0 20840 27468 0.000287825002398541 0.000105633792978048 0.000626367784710498 1 0.999865711673152 1 1 0.540741873560099 1 1 0.025 1 1 0.025 1 Inf 0.0337940631452161 Inf 0.431410296218095 607.5 5574 False False Inf 1.55167078958407 Inf 4.79823424979607e-05 1.21480699612118e-06 0.000267311181643879 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 1 0.025 1 1 0.025 1 Inf 0.0408678013770354 Inf 0.385526884820527 489.5 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 7.47831289261142e-05 1.89334310623943e-06 0.000416593707936992 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Asp440Glu katG_p.Asp440Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3495 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2816 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Asp440Tyr katG_p.Asp440Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3053 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Asp448Ala katG_p.Asp448Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 14 0 20832 27468 0.000671591672263264 0.000367212509754494 0.00112656023057506 1 0.999865711673152 1 1 0.768364238349883 1 NA NA NA NA NA NA NA NA NA NA 3145 5574 False False Inf 4.37287801662981 Inf 0 0 0.000177061869457058 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 11 0 13363 21313 0.000822491401226259 0.000410653977896139 0.00147118664271154 1 0.999826933785262 1 1 0.715085847081845 1 NA NA NA NA NA NA NA NA NA NA 2550 4479 False False 0 0 0 0 0 0 0 Inf 4.00162721599209 Inf 0 0 0.000276013645151466 1 0.999826933785262 1 12 3) Uncertain significance No change no 1 +Isoniazid katG p.Asp487Asn katG_p.Asp487Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 3 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.544526627735454 Inf 0.0803181469117723 287 5574 False False Inf 0.544526627735454 Inf 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Asp509Asn katG_p.Asp509Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Asp511Asn katG_p.Asp511Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Asp511Tyr katG_p.Asp511Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Asp513_Leu514insHis katG_p.Asp513_Leu514insHis 1 inframe_insertion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Isoniazid katG p.Asp513Asn katG_p.Asp513Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3278 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2650 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Asp513fs katG_p.Asp513fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3203 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2593 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Asp542Glu katG_p.Asp542Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2975 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Isoniazid katG p.Asp56Asn katG_p.Asp56Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3223 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Asp56fs katG_p.Asp56fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3262 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2638 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Asp573Asn katG_p.Asp573Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3166 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2569 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Asp580Glu katG_p.Asp580Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Asp656Ala katG_p.Asp656Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 1 7 1 7 20845 27461 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999745158002038 0.999474999027776 0.999897534357495 0.125 0.0031597235312519 0.526509670875206 0.125 0.0031597235312519 0.526509670875206 0.125 0.0031597235312519 0.526509670875206 0.188198608779083 0.00417990056987037 1.46513319151887 0.149408043631335 367 5574 False False 0.188198608779083 0.00417990056987037 1.46513319151887 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999745158002038 0.999474999027776 0.999897534357495 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Asp656fs katG_p.Asp656fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2946 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Asp656Gly katG_p.Asp656Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3350 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Asp663Gly katG_p.Asp663Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Asp663Tyr katG_p.Asp663Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3204 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2594 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Asp675His katG_p.Asp675His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Asp675Tyr katG_p.Asp675Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 2 20843 27466 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999927188000582 0.999737003036386 0.999991182007438 0.6 0.146632799634673 0.947255049473683 0 0 0.975 0 0 0.841886116991581 0 0 51.3539402930048 1 2027.5 5574 False False 1.97663484143357 0.226402568392661 23.6672561646805 0 0 0.00017696843241753 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 2 13371 21311 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999906160559283 0.999661061221376 0.999988635406343 0.6 0.146632799634673 0.947255049473683 0 0 0.975 0 0 0.841886116991581 0 0 62.1026435994552 1 1642.5 4479 False False 0 0 0 0 0 0 0 2.39073367736145 0.273835790357664 28.6284716983702 0 0 0.000275848526268708 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Asp682Asn katG_p.Asp682Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01632529799099 0.509386028876591 1135.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Asp695fs katG_p.Asp695fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Asp723Ala katG_p.Asp723Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3380 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2734 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Asp723Asn katG_p.Asp723Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2988 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2433 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Asp729Asn katG_p.Asp729Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Asp729fs katG_p.Asp729fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Asp729Glu katG_p.Asp729Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3401 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2752 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Asp729Gly katG_p.Asp729Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3224 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2611 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Asp735Ala katG_p.Asp735Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 3 1 20843 27467 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999963594000291 0.999797175631493 0.999999078280314 0.75 0.194120449683243 0.99369053679029 1 0.158113883008419 1 0.666666666666666 0.0942993240502461 0.991596241340387 Inf 0.247474761827698 Inf 0.18615809249565 394.5 5574 False False 3.95341361608213 0.31739219148065 207.323829234655 9.59462700887503e-05 1.16197496419179e-05 0.000346547484278011 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2830 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain AwRI by relaxed thresholds (not endorsed) yes O 0 +Isoniazid katG p.Asp735Asn katG_p.Asp735Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3402 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2753 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Asp735Glu katG_p.Asp735Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Asp735Tyr katG_p.Asp735Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3476 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Asp74Gly katG_p.Asp74Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 7.01573328293188 0.509380354735251 864 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.48495357236853 0.526173219289417 690 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Asp79Ala katG_p.Asp79Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Asp94Ala katG_p.Asp94Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 3 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.544552746865154 Inf 0.0803115749774769 281 5574 False False Inf 0.869878292971449 Inf 0.000143919405133125 2.96806247414452e-05 0.000420535394770913 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.299330161198724 Inf 0.148637808646281 204 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0.000149555073655873 1.81123264336181e-05 0.000540138824607934 1 0.999826933785262 1 NA 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Asp94Gly katG_p.Asp94Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 3 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.544552746865154 Inf 0.0803115749774769 281 5574 False False Inf 0.869878292971449 Inf 0.000143919405133125 2.96806247414452e-05 0.000420535394770913 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.040864745349235 Inf 0.385544600126852 512 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 7.47775368279368e-05 1.89320152683959e-06 0.000416562561410248 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain AwRI by relaxed thresholds (not endorsed) yes O 0 +Isoniazid katG p.Asp94Tyr katG_p.Asp94Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3324 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2689 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Cys171Gly katG_p.Cys171Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3084 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2506 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Cys171* katG_p.Cys171* 1 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3167 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2570 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Cys20fs katG_p.Cys20fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2947 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2398 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Cys549Ser katG_p.Cys549Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gln127Arg katG_p.Gln127Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Gln127Pro katG_p.Gln127Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 2 2 23 4 20823 27464 0.00110332917586107 0.000699540579283756 0.00165507836011506 0.999854376001165 0.999627187086024 0.999960320981843 0.851851851851851 0.662689135975755 0.958112603526232 0.5 0.067585986488543 0.932414013511457 0.333333333333333 0.0432718682927417 0.777221904496487 1.31892618738894 0.0956171768118081 18.1932690277472 1 2027.5 5574 False False 7.58382557748643 2.59051327219802 30.1767985714208 9.60384153661464e-05 1.16309092683913e-05 0.000346880261240731 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 15 1 13359 21312 0.00112157918349035 0.000627870944551516 0.00184920065907577 0.999953080279641 0.999738608085756 0.999998812096234 0.9375 0.697679261565468 0.998418888277234 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.59532899169099 0.0203218311314986 125.114658535638 1 1005 4479 False False 0 0 0 0 0 0 0 23.9299348753649 3.6805277242921 1002.68796542838 7.48502994011976e-05 1.89504371220852e-06 0.000416967829882676 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Gln295Ala katG_p.Gln295Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gln295Lys katG_p.Gln295Lys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 9 0 20837 27468 0.000431737503597812 0.000197436276106449 0.000819413341228355 1 0.999865711673152 1 1 0.663732883120057 1 NA NA NA NA NA NA NA NA NA NA 2948 5574 False False Inf 2.60134945111117 Inf 0 0 0.000177019385846931 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 6 0 13368 21313 0.000448631673396141 0.000164657143425453 0.000976224581517196 1 0.999826933785262 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 2399 4479 False False 0 0 0 0 0 0 0 Inf 1.87681913692541 Inf 0 0 0.00027591042269331 1 0.999826933785262 1 4 3) Uncertain significance No change no 1 +Isoniazid katG p.Gln295Pro katG_p.Gln295Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0337875782094303 Inf 0.431457371721896 645 5574 False False Inf 0.247471899512553 Inf 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.040864745349235 Inf 0.385544600126852 512 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 7.47775368279368e-05 1.89320152683959e-06 0.000416562561410248 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gln352His katG_p.Gln352His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2949 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2400 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Gln352Pro katG_p.Gln352Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gln352* katG_p.Gln352* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0337875782094303 Inf 0.431457371721896 645 5574 False False Inf 0.247471899512553 Inf 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.040864745349235 Inf 0.385544600126852 512 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 7.47775368279368e-05 1.89320152683959e-06 0.000416562561410248 1 0.999826933785262 1 NA Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Gln352Tyr katG_p.Gln352Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gln36Glu katG_p.Gln36Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3340 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gln36Pro katG_p.Gln36Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3180 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 2578 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gln434His katG_p.Gln434His 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gln439Arg katG_p.Gln439Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.24748377190611 Inf 0.186150386160192 389.5 5574 False False Inf 0.544526627735454 Inf 9.59462700887503e-05 1.16197496419179e-05 0.000346547484278011 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.299330161198724 Inf 0.148637808646281 204 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0.000149555073655873 1.81123264336181e-05 0.000540138824607934 1 0.999826933785262 1 NA 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Gln439His katG_p.Gln439His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 6 0 20840 27468 0.000287825002398541 0.000105633792978048 0.000626367784710498 1 0.999865711673152 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 3434 5574 False False Inf 1.55167078958407 Inf 0 0 0.000176993905465082 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 6 0 13368 21313 0.000448631673396141 0.000164657143425453 0.000976224581517196 1 0.999826933785262 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 2774 4479 False False 0 0 0 0 0 0 0 Inf 1.87681913692541 Inf 0 0 0.00027591042269331 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Gln439Lys katG_p.Gln439Lys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3516 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2831 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Gln439Pro katG_p.Gln439Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 3 1 20843 27467 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999963594000291 0.999797175631493 0.999999078280314 0.75 0.194120449683243 0.99369053679029 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0337879690601309 Inf 0.431454534164062 624 5574 False False 3.95341361608213 0.31739219148065 207.323829234655 4.79754365764728e-05 1.21463215353938e-06 0.000267272712750976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 3 1 13371 21312 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999953080279641 0.999738608085756 0.999998812096234 0.75 0.194120449683243 0.99369053679029 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0408658838497156 Inf 0.385538000230653 494 4479 False False 0 0 0 0 0 0 0 4.78169172088849 0.383875689805931 250.696170545132 7.47831289261142e-05 1.89334310623943e-06 0.000416593707936992 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Gln439Tyr katG_p.Gln439Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gln461Arg katG_p.Gln461Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gln461Glu katG_p.Gln461Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3205 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2595 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gln461Pro katG_p.Gln461Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 2 2 6 3 20840 27465 0.000287825002398541 0.000105633792978048 0.000626367784710498 0.999890782000873 0.99968085216583 0.999977476056514 0.666666666666666 0.29929505620854 0.925145368580308 0.5 0.067585986488543 0.932414013511457 0.4 0.0527449505263169 0.853367200365326 1.31789827255278 0.0955426929116665 18.1790819041473 1 2027.5 5574 False False 2.63579654510556 0.562830574439234 16.2901193363597 9.59600806064677e-05 1.16214222204938e-05 0.00034659736011256 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 2 1 4 2 13370 21311 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 0.999906160559283 0.999661061221376 0.999988635406343 0.666666666666666 0.222778095503512 0.956728131707258 0.666666666666666 0.0942993240502461 0.991596241340387 0.5 0.067585986488543 0.932414013511457 3.18788332086761 0.165933123418327 187.871968007592 0.563287430651071 990 4479 False False 0 0 0 0 0 0 0 3.18788332086761 0.456775580099959 35.246992707007 0.000149566257852228 1.81136809684436e-05 0.000540179209988093 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Gln471Arg katG_p.Gln471Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3308 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2677 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gln4Tyr katG_p.Gln4Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Gln50_Asn51insThr katG_p.Gln50_Asn51insThr 1 inframe_insertion (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3294 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2665 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Isoniazid katG p.Gln50Pro katG_p.Gln50Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gln525Ala katG_p.Gln525Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gln525fs katG_p.Gln525fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2989 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Gln525Pro katG_p.Gln525Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 4 1 6 1 20840 27467 0.000287825002398541 0.000105633792978048 0.000626367784710498 0.999963594000291 0.999797175631493 0.999999078280314 0.857142857142857 0.421276802956804 0.996389703138099 0.8 0.28358206388191 0.994949236620532 0.8 0.28358206388191 0.994949236620532 5.27197696737044 0.521639451481707 259.304019218399 0.172840589227032 372.5 5574 False False 7.90796545105566 0.959277004805377 363.132004070954 0.000191901746305891 5.22891630665053e-05 0.000491271127280021 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 4 1 4 1 13370 21312 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 0.999953080279641 0.999738608085756 0.999998812096234 0.8 0.28358206388191 0.994949236620532 0.8 0.28358206388191 0.994949236620532 0.8 0.28358206388191 0.994949236620532 6.37606581899775 0.630846560224411 313.513380938872 0.0763990339932966 150 4479 False False 0 0 0 0 0 0 0 6.37606581899775 0.630846560224411 313.513380938872 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Gln525Ser katG_p.Gln525Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gln525Thr katG_p.Gln525Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3099 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2517 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gln576Tyr katG_p.Gln576Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3435 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2775 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gln578Arg katG_p.Gln578Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3225 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2612 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Gln578fs katG_p.Gln578fs 1 frameshift (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Gln578Pro katG_p.Gln578Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3517 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Gln679Glu katG_p.Gln679Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3496 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Gln679Pro katG_p.Gln679Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3206 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2596 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gln679Tyr katG_p.Gln679Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3403 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2754 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gln88Glu katG_p.Gln88Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gln88Pro katG_p.Gln88Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3181 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2579 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gln88* katG_p.Gln88* 1 stop_gained (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3325 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2690 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Glu10fs katG_p.Glu10fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2990 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2434 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Glu195_Asn236del katG_p.Glu195_Asn236del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Isoniazid katG p.Glu195Lys katG_p.Glu195Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Glu208Ala katG_p.Glu208Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3404 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2755 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Glu208fs katG_p.Glu208fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3326 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2691 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Glu233_Pro239del katG_p.Glu233_Pro239del 1 inframe_deletion (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Isoniazid katG p.Glu233Gln katG_p.Glu233Gln 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3477 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Glu233Gly katG_p.Glu233Gly 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 0 1 3 1 20843 27467 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999963594000291 0.999797175631493 0.999999078280314 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 51.3558084523276 1 2027.5 5574 False False 3.95341361608213 0.31739219148065 207.323829234655 0 0 0.00017696843241753 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 0 1 3 1 13371 21312 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999953080279641 0.999738608085756 0.999998812096234 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 62.1055547471297 1 1642.5 4479 False False 0 0 0 0 0 0 0 4.78169172088849 0.383875689805931 250.696170545132 0 0 0.000275848526268708 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Glu233Lys katG_p.Glu233Lys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3069 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2493 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Glu287Gly katG_p.Glu287Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3518 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Glu289Ala katG_p.Glu289Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2950 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Glu289Gly katG_p.Glu289Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3130 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Glu294Gly katG_p.Glu294Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3054 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance No change no 1 +Isoniazid katG p.Glu318Ala katG_p.Glu318Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Glu31Ala katG_p.Glu31Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Glu342Ala katG_p.Glu342Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.31767810026385 0.0167927522337569 103.35711725526 1 1253.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Glu342fs katG_p.Glu342fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3131 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2540 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Glu391Asp katG_p.Glu391Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3309 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2678 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Glu399Asp katG_p.Glu399Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Glu3fs katG_p.Glu3fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 3279 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 2651 4479 False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 0 0 0.000275827900298067 0.999953080279641 0.999738608085756 0.999998812096234 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Glu3Gly katG_p.Glu3Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 5 0 20841 27468 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 1 0.999865711673152 1 1 0.478176249895018 1 1 0.025 1 1 0.025 1 Inf 0.033792441677911 Inf 0.43142206582488 609.5 5574 False False Inf 1.20760984683633 Inf 4.79800403032338e-05 1.21474870966795e-06 0.000267298357449221 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 1 0.025 1 1 0.025 1 Inf 0.0408678013770354 Inf 0.385526884820527 489.5 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 7.47831289261142e-05 1.89334310623943e-06 0.000416593707936992 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Glu3Val katG_p.Glu3Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2951 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2401 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Glu402Ala katG_p.Glu402Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Glu402Lys katG_p.Glu402Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 1 3 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.439194051331254 0.00837049629364692 5.4704842261679 0.638942720978879 1228.5 5574 False False 0.439194051331254 0.00837049629364692 5.4704842261679 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Glu407Lys katG_p.Glu407Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Glu454Ala katG_p.Glu454Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2976 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2422 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Glu506Asp katG_p.Glu506Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 51.3533466119536 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Glu522Gln katG_p.Glu522Gln 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3497 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Glu522Lys katG_p.Glu522Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Glu523Asp katG_p.Glu523Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Glu526Asp katG_p.Glu526Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Glu526Lys katG_p.Glu526Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Glu553Lys katG_p.Glu553Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Glu582fs katG_p.Glu582fs 1 frameshift (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Glu588Gly katG_p.Glu588Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.247471899512553 Inf 0.186160540855956 404 5574 False False Inf 0.247471899512553 Inf 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.299307766452077 Inf 0.148651468333857 217.5 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 NA 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Glu588* katG_p.Glu588* 1 stop_gained (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3070 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Glu607Asp katG_p.Glu607Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3115 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2529 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Glu607Gly katG_p.Glu607Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0337875782094303 Inf 0.431457371721896 645 5574 False False Inf 0.247471899512553 Inf 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.040864745349235 Inf 0.385544600126852 512 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 7.47775368279368e-05 1.89320152683959e-06 0.000416562561410248 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Glu607Lys katG_p.Glu607Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0337875782094303 Inf 0.431457371721896 645 5574 False False Inf 0.247471899512553 Inf 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2423 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Glu607* katG_p.Glu607* 1 stop_gained (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2991 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2435 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Glu623Ala katG_p.Glu623Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Glu623fs katG_p.Glu623fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3405 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2756 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Glu623Gly katG_p.Glu623Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3381 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2735 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Glu648fs katG_p.Glu648fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3033 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2467 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Glu651Asp katG_p.Glu651Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 20846 27462 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.11900921779861 0.0402109359097128 194.5 5574 False False 0 0 1.11900921779861 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Glu651fs katG_p.Glu651fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3116 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2530 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Glu669fs katG_p.Glu669fs 1 frameshift (see "Genomic_coordinates" sheet) 1 3 3 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.544526627735454 Inf 0.0803181469117723 287 5574 False False Inf 0.544526627735454 Inf 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 3 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.65857349539183 Inf 0.0573091375107495 145 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change AwRI by relaxed thresholds (not endorsed) no G, O 1 +Isoniazid katG p.Glu67del katG_p.Glu67del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Isoniazid katG p.Glu709Ala katG_p.Glu709Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 1 0.025 1 1 0.025 1 Inf 0.0337891992100405 Inf 0.431445603576751 617.5 5574 False False Inf 0.544526627735454 Inf 4.79754365764728e-05 1.21463215353938e-06 0.000267272712750976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.040864745349235 Inf 0.385544600126852 512 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 7.47775368279368e-05 1.89320152683959e-06 0.000416562561410248 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Glu709Asp katG_p.Glu709Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3460 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2793 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 1 3) Uncertain significance No change no 1 +Isoniazid katG p.Glu709Gly katG_p.Glu709Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0337875782094303 Inf 0.431457371721896 645 5574 False False Inf 0.247471899512553 Inf 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Glu81Ala katG_p.Glu81Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3498 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Glu82Asp katG_p.Glu82Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.43785249906968 0.0743380732312645 251 5574 False False 0 0 1.43785249906968 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 13374 21308 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.73894646374006 0.163960020972012 248.5 4479 False False 0 0 0 0 0 0 0 0 0 1.73894646374006 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Glu82Gly katG_p.Glu82Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 1.99597553667858 0.139114336996004 304.5 5574 False False 0 0 1.43785249906968 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 5 13374 21308 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 2.41409066157565 0.305475026346142 461 4479 False False 0 0 0 0 0 0 0 0 0 1.73894646374006 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Gly111Asp katG_p.Gly111Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Gly111Cys katG_p.Gly111Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3117 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2531 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Gly118Ser katG_p.Gly118Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 3 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.544552746865154 Inf 0.0803115749774769 281 5574 False False Inf 0.869878292971449 Inf 0.000143919405133125 2.96806247414452e-05 0.000420535394770913 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 3 0 4 0 13370 21313 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 1 0.999826933785262 1 1 0.397635364383525 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.658622746210869 Inf 0.0573012380178015 143 4479 False False 0 0 0 0 0 0 0 Inf 1.05210128917758 Inf 0.00022433261048381 4.62651669632347e-05 0.00065545373138314 1 0.999826933785262 1 NA 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Gly120Asp katG_p.Gly120Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly120Ser katG_p.Gly120Ser 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 1 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0337875782094303 Inf 0.431457371721896 645 5574 False False Inf 0.247471899512553 Inf 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly121Ala katG_p.Gly121Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.31767810026385 0.0167927522337569 103.35711725526 1 1253.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly121Asp katG_p.Gly121Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 2 20844 27466 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999927188000582 0.999737003036386 0.999991182007438 0.5 0.067585986488543 0.932414013511457 1 0.158113883008419 1 0.5 0.067585986488543 0.932414013511457 Inf 0.247453880220188 Inf 0.18617595452717 414.5 5574 False False 1.3176933410094 0.0955278435529395 18.1762534351792 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.299307766452077 Inf 0.148651468333857 217.5 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 NA 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Gly121del katG_p.Gly121del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0337875782094303 Inf 0.431457371721896 645 5574 False False Inf 0.247471899512553 Inf 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Isoniazid katG p.Gly121Ser katG_p.Gly121Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 7 3 20839 27465 0.000335795836131632 0.000135017659185429 0.000691744589626827 0.999890782000873 0.99968085216583 0.999977476056514 0.7 0.347547149940002 0.933260488822265 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18972436041205 0.264108098295479 572.5 5574 False False 3.07524353375881 0.70193019624619 18.4306658389899 0 0 0.00017700239811062 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48598624162872 0.526186417038858 925 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly121Val katG_p.Gly121Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly124Ala katG_p.Gly124Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3461 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2794 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly124Asp katG_p.Gly124Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly124del katG_p.Gly124del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0337875782094303 Inf 0.431457371721896 645 5574 False False Inf 0.247471899512553 Inf 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2757 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 1 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Isoniazid katG p.Gly124fs katG_p.Gly124fs 1 frameshift (see "Genomic_coordinates" sheet) 1 4 4 0 8 0 20838 27468 0.000383766669864722 0.000165697303700768 0.000756032532322191 1 0.999865711673152 1 1 0.63058335244718 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 0.870045268878141 Inf 0.0346368448496275 178 5574 False False Inf 2.24970730189478 Inf 0.000191920161212935 5.22941809687646e-05 0.000491318262637833 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 6 0 13368 21313 0.000448631673396141 0.000164657143425453 0.000976224581517196 1 0.999826933785262 1 1 0.540741873560099 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.299397365529957 Inf 0.148596828623885 198.5 4479 False False 0 0 0 0 0 0 0 Inf 1.87681913692541 Inf 0.000149588631264023 1.8116390645981e-05 0.00054025999886845 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change AwRI by relaxed thresholds (not endorsed) no G, O 1 +Isoniazid katG p.Gly125Ala katG_p.Gly125Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3226 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2613 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly125Asp katG_p.Gly125Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.24748377190611 Inf 0.186150386160192 389.5 5574 False False Inf 0.544526627735454 Inf 9.59462700887503e-05 1.16197496419179e-05 0.000346547484278011 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Gly125Cys katG_p.Gly125Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3227 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly125Ser katG_p.Gly125Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 51.3533466119536 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 62.1009148060541 1 1642.5 4479 False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 0 0 0.000275827900298067 0.999953080279641 0.999738608085756 0.999998812096234 3 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly156Asp katG_p.Gly156Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 1 0.158113883008419 1 0.666666666666666 0.0942993240502461 0.991596241340387 Inf 0.247462889866372 Inf 0.186168247452282 413 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.299307766452077 Inf 0.148651468333857 217.5 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 NA 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Gly156Ser katG_p.Gly156Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Gly169Ala katG_p.Gly169Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2952 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2402 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Gly169Arg katG_p.Gly169Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3008 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2448 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Gly169Ser katG_p.Gly169Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 6 0 20840 27468 0.000287825002398541 0.000105633792978048 0.000626367784710498 1 0.999865711673152 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 3382 5574 False False Inf 1.55167078958407 Inf 0 0 0.000176993905465082 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly169Val katG_p.Gly169Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3327 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2692 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly177Ala katG_p.Gly177Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3406 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2758 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly177Val katG_p.Gly177Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly182Arg katG_p.Gly182Arg 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 1 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0337875782094303 Inf 0.431457371721896 645 5574 False False Inf 0.247471899512553 Inf 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.040864745349235 Inf 0.385544600126852 512 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 7.47775368279368e-05 1.89320152683959e-06 0.000416562561410248 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly182Glu katG_p.Gly182Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3310 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2679 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Gly184Asp katG_p.Gly184Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2953 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2403 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly186Ala katG_p.Gly186Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3182 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2580 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly186Asp katG_p.Gly186Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3407 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2759 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly19Val katG_p.Gly19Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 1.99604811372315 0.139118032244638 322.5 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.41420404242617 0.305473156458586 444 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly206Arg katG_p.Gly206Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3367 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2722 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly206Asp katG_p.Gly206Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3168 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly212fs katG_p.Gly212fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0337875782094303 Inf 0.431457371721896 645 5574 False False Inf 0.247471899512553 Inf 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2693 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Gly234Arg katG_p.Gly234Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 2 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 2.63548263289195 0.137183409715989 155.34952410964 0.581601386260749 1225.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.299307766452077 Inf 0.148651468333857 217.5 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 NA 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Gly234Glu katG_p.Gly234Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3478 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2806 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Gly237Ala katG_p.Gly237Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly268fs katG_p.Gly268fs 1 frameshift (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Gly268Ser katG_p.Gly268Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3085 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2507 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly269Asp katG_p.Gly269Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Gly269Ser katG_p.Gly269Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly273Cys katG_p.Gly273Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3408 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly273Ser katG_p.Gly273Ser 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Gly277Asp katG_p.Gly277Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3311 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2680 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Gly277Ser katG_p.Gly277Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2977 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2424 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly279Asp katG_p.Gly279Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 6 0 8 0 20838 27468 0.000383766669864722 0.000165697303700768 0.000756032532322191 1 0.999865711673152 1 1 0.63058335244718 1 1 0.540741873560099 1 1 0.540741873560099 1 Inf 1.55181970047793 Inf 0.00644731031254025 109 5574 False False Inf 2.24970730189478 Inf 0.000287852619458837 0.000105643929313142 0.000626427875068139 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 3 0 4 0 13370 21313 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 1 0.999826933785262 1 1 0.397635364383525 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.658622746210869 Inf 0.0573012380178015 143 4479 False False 0 0 0 0 0 0 0 Inf 1.05210128917758 Inf 0.00022433261048381 4.62651669632347e-05 0.00065545373138314 1 0.999826933785262 1 2 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Gly279fs katG_p.Gly279fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3228 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2614 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Gly285Ala katG_p.Gly285Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly285Arg katG_p.Gly285Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3009 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2449 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly285Asp katG_p.Gly285Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly285Cys katG_p.Gly285Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 11 0 20835 27468 0.000527679171063993 0.000263444034397523 0.000943967185544106 1 0.999865711673152 1 1 0.715085847081845 1 1 0.025 1 1 0.025 1 Inf 0.0338021728163356 Inf 0.431351440874461 597.5 5574 False False Inf 3.30816067473776 Inf 4.79938567863313e-05 1.21509851230904e-06 0.000267375321079624 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 10 0 13364 21313 0.000747719455660236 0.000358616922835118 0.00137465137870696 1 0.999826933785262 1 1 0.691502892181239 1 NA NA NA NA NA NA NA NA NA NA 2666 4479 False False 0 0 0 0 0 0 0 Inf 3.57391601991246 Inf 0 0 0.000275992994481552 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly285Ser katG_p.Gly285Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3229 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2615 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly285Val katG_p.Gly285Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 2 2 3 2 20843 27466 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999927188000582 0.999737003036386 0.999991182007438 0.6 0.146632799634673 0.947255049473683 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 1.31775656095571 0.0955324245640855 18.1771259836516 1 2027.5 5574 False False 1.97663484143357 0.226402568392661 23.6672561646805 9.59462700887503e-05 1.16197496419179e-05 0.000346547484278011 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.59377804367334 0.0203020758039404 124.993150249237 1 1642.5 4479 False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 7.47775368279368e-05 1.89320152683959e-06 0.000416562561410248 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Gly297Val katG_p.Gly297Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 4 1 6 1 20840 27467 0.000287825002398541 0.000105633792978048 0.000626367784710498 0.999963594000291 0.999797175631493 0.999999078280314 0.857142857142857 0.421276802956804 0.996389703138099 0.8 0.28358206388191 0.994949236620532 0.8 0.28358206388191 0.994949236620532 5.27197696737044 0.521639451481707 259.304019218399 0.172840589227032 372.5 5574 False False 7.90796545105566 0.959277004805377 363.132004070954 0.000191901746305891 5.22891630665053e-05 0.000491271127280021 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 4 1 6 1 13368 21312 0.000448631673396141 0.000164657143425453 0.000976224581517196 0.999953080279641 0.999738608085756 0.999998812096234 0.857142857142857 0.421276802956804 0.996389703138099 0.8 0.28358206388191 0.994949236620532 0.8 0.28358206388191 0.994949236620532 6.3770197486535 0.630940924581741 313.560199838906 0.0763740826400526 148 4479 False False 0 0 0 0 0 0 0 9.56552962298025 1.16026312817987 439.068355223953 0.000299132515704457 8.15093646869179e-05 0.000765719314786932 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Gly299Ala katG_p.Gly299Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3351 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2710 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly299Asp katG_p.Gly299Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3207 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2597 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly299Cys katG_p.Gly299Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Gly299Ser katG_p.Gly299Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 6 0 20840 27468 0.000287825002398541 0.000105633792978048 0.000626367784710498 1 0.999865711673152 1 1 0.540741873560099 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.247519395922597 Inf 0.186119921212534 379 5574 False False Inf 1.55167078958407 Inf 9.59600806064677e-05 1.16214222204938e-05 0.00034659736011256 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 1 0.025 1 1 0.025 1 Inf 0.0408678013770354 Inf 0.385526884820527 489.5 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 7.47831289261142e-05 1.89334310623943e-06 0.000416593707936992 1 0.999826933785262 1 NA 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Gly305Cys katG_p.Gly305Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly305Ser katG_p.Gly305Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3383 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly307Arg katG_p.Gly307Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3312 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2681 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Gly307Glu katG_p.Gly307Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3086 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2508 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly307Val katG_p.Gly307Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3295 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2667 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly338Asp katG_p.Gly338Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Gly338Ser katG_p.Gly338Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.31767810026385 0.0167927522337569 103.35711725526 1 1253.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.59365886487699 0.0203005577541163 124.983813232444 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly33Ala katG_p.Gly33Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3368 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly34Ala katG_p.Gly34Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3034 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly34Arg katG_p.Gly34Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3169 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly34fs katG_p.Gly34fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3071 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2494 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Gly34Glu katG_p.Gly34Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3183 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly358fs katG_p.Gly358fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3100 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2518 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Gly369Ala katG_p.Gly369Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3250 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2632 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Gly369fs katG_p.Gly369fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Gly421Ala katG_p.Gly421Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3010 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly428Glu katG_p.Gly428Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3479 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2807 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Gly451Asp katG_p.Gly451Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly466Arg katG_p.Gly466Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly490Ala katG_p.Gly490Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3170 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly490Ser katG_p.Gly490Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3101 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2519 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Gly491Ala katG_p.Gly491Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3384 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2736 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Gly491Ser katG_p.Gly491Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 3 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.544526627735454 Inf 0.0803181469117723 287 5574 False False Inf 0.544526627735454 Inf 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Gly494Ala katG_p.Gly494Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 2 20843 27466 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999927188000582 0.999737003036386 0.999991182007438 0.6 0.146632799634673 0.947255049473683 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3208 5574 False False 1.97663484143357 0.226402568392661 23.6672561646805 0 0 0.00017696843241753 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 1 13371 21312 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999953080279641 0.999738608085756 0.999998812096234 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 2598 4479 False False 0 0 0 0 0 0 0 4.78169172088849 0.383875689805931 250.696170545132 0 0 0.000275848526268708 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly494Ser katG_p.Gly494Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 1 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly495Ala katG_p.Gly495Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3341 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2703 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly495Ser katG_p.Gly495Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 19 8 11 9 11 20837 27457 0.000431737503597812 0.000197436276106449 0.000819413341228355 0.999599534003203 0.9992835689522 0.999800072407065 0.45 0.230577896775924 0.684721866959451 0.421052631578947 0.202521438977162 0.665002155988264 0.421052631578947 0.202521438977162 0.665002155988264 0.958330242968146 0.334577261498232 2.61643069152496 1 2027.5 5574 False False 1.07812152333916 0.394796214036334 2.86252654962574 0.000383785080355001 0.000165705253396195 0.000756068794818417 0.999599534003203 0.9992835689522 0.999800072407065 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 18 7 11 8 11 13366 21302 0.000598175564528189 0.000258283997825234 0.00117830226263269 0.999483883076056 0.999076712346733 0.999742329032819 0.421052631578947 0.202521438977162 0.665002155988264 0.388888888888888 0.172985854789751 0.642548794106937 0.388888888888888 0.172985854789751 0.642548794106937 1.01420156979037 0.333275502264902 2.86574364654155 1 1005 4479 False False 0 0 0 0 0 0 0 1.15908750833185 0.404620520690662 3.16460419465185 0.000523442757795558 0.000210476208336433 0.00107819284954331 0.999483883076056 0.999076712346733 0.999742329032819 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly534Arg katG_p.Gly534Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 7.01573328293188 0.509380354735251 864 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.48495357236853 0.526173219289417 690 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly548Arg katG_p.Gly548Arg 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly560Ala katG_p.Gly560Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 51.3533466119536 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 62.1009148060541 1 1642.5 4479 False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 0 0 0.000275827900298067 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly560Arg katG_p.Gly560Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3436 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2776 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly560Ser katG_p.Gly560Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.658815063564403 0.011171855707321 12.6567401482543 1 2027.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly570Phe katG_p.Gly570Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly570Ser katG_p.Gly570Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3209 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Gly593Asp katG_p.Gly593Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3011 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2450 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly593Cys katG_p.Gly593Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 1.99604811372315 0.139118032244638 322.5 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.41420404242617 0.305473156458586 444 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly593Ser katG_p.Gly593Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2468 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly599Arg katG_p.Gly599Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2992 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2436 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Gly601Asp katG_p.Gly601Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly601fs katG_p.Gly601fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3210 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2599 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Gly629Asp katG_p.Gly629Asp 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly629Cys katG_p.Gly629Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0337875782094303 Inf 0.431457371721896 645 5574 False False Inf 0.247471899512553 Inf 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.040864745349235 Inf 0.385544600126852 512 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 7.47775368279368e-05 1.89320152683959e-06 0.000416562561410248 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly630Ser katG_p.Gly630Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 1 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly635Ala katG_p.Gly635Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3280 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2652 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly644Asp katG_p.Gly644Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3519 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2832 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly683Arg katG_p.Gly683Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3087 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2509 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly685Asp katG_p.Gly685Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2993 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly699Arg katG_p.Gly699Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.247471899512553 Inf 0.186160540855956 404 5574 False False Inf 0.247471899512553 Inf 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain AwRI by relaxed thresholds (not endorsed) yes O 0 +Isoniazid katG p.Gly699Glu katG_p.Gly699Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 7 1 9 1 20837 27467 0.000431737503597812 0.000197436276106449 0.000819413341228355 0.999963594000291 0.999797175631493 0.999999078280314 0.9 0.554983882971804 0.997471421455538 0.875 0.473490329124793 0.996840276468748 0.875 0.473490329124793 0.996840276468748 9.22728799731247 1.1852515558114 415.069093949533 0.0247657202663148 172 5574 False False 11.8636559965446 1.6436266007203 518.765276537541 0.000335828056035309 0.000135030615237893 0.000691810951305092 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 7 1 9 1 13365 21312 0.000672947510094212 0.000307759154923187 0.00127707788784856 0.999953080279641 0.999738608085756 0.999998812096234 0.9 0.554983882971804 0.997471421455538 0.875 0.473490329124793 0.996840276468748 0.875 0.473490329124793 0.996840276468748 11.1622895622895 1.43370074196835 501.880713159065 0.00670529622226596 68 4479 False False 0 0 0 0 0 0 0 14.3515151515151 1.98814481377699 627.199072547492 0.000523481902482799 0.000210491950281334 0.00107827345779626 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Gly699Val katG_p.Gly699Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Gly712Asp katG_p.Gly712Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Gly712Val katG_p.Gly712Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3263 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly99Arg katG_p.Gly99Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2954 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2404 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Gly99Glu katG_p.Gly99Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 4 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.His108Arg katG_p.His108Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.His116Tyr katG_p.His116Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.His25fs katG_p.His25fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3211 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.His270Pro katG_p.His270Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3313 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.His400fs katG_p.His400fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 1 0.025 1 1 0.025 1 Inf 0.0337891992100405 Inf 0.431445603576751 617.5 5574 False False Inf 0.544526627735454 Inf 4.79754365764728e-05 1.21463215353938e-06 0.000267272712750976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.040864745349235 Inf 0.385544600126852 512 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 7.47775368279368e-05 1.89320152683959e-06 0.000416562561410248 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.His447Arg katG_p.His447Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3437 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.His49Tyr katG_p.His49Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 51.3533466119536 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2551 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.His561Arg katG_p.His561Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.His561fs katG_p.His561fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3012 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.His97Leu katG_p.His97Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 1 0.025 1 1 0.025 1 Inf 0.0337891992100405 Inf 0.431445603576751 617.5 5574 False False Inf 0.544526627735454 Inf 4.79754365764728e-05 1.21463215353938e-06 0.000267272712750976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 1 0.025 1 1 0.025 1 Inf 0.0408678013770354 Inf 0.385526884820527 489.5 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 7.47831289261142e-05 1.89334310623943e-06 0.000416593707936992 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.His97Tyr katG_p.His97Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3088 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Ile103Asn katG_p.Ile103Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ile103Val katG_p.Ile103Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3146 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2552 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ile228Leu katG_p.Ile228Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3055 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2483 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ile248Thr katG_p.Ile248Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 5 0 20841 27468 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 1 0.999865711673152 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 3072 5574 False False Inf 1.20760984683633 Inf 0 0 0.000176985413634466 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 5 0 13369 21313 0.000373859727830118 0.000121402023062639 0.000872246401868143 1 0.999826933785262 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 2495 4479 False False 0 0 0 0 0 0 0 Inf 1.46057233596553 Inf 0 0 0.000275889787465637 1 0.999826933785262 1 1 3) Uncertain significance No change no 1 +Isoniazid katG p.Ile248Val katG_p.Ile248Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3056 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ile266Thr katG_p.Ile266Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ile317Val katG_p.Ile317Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 23 1 20823 27467 0.00110332917586107 0.000699540579283756 0.00165507836011506 0.999963594000291 0.999797175631493 0.999999078280314 0.958333333333333 0.788798316543026 0.99894564755453 NA NA NA 0 0 0.975 NA NA NA NA 2978 5574 False False 30.3386159535129 4.92542534790948 1242.54352909132 0 0 0.000177138391364407 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 7 0 13367 21313 0.000523403618962165 0.000210460468745924 0.00107811225334149 1 0.999826933785262 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 2425 4479 False False 0 0 0 0 0 0 0 Inf 2.29755378883993 Inf 0 0 0.000275931061008045 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ile335fs katG_p.Ile335fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0337875782094303 Inf 0.431457371721896 645 5574 False False Inf 0.247471899512553 Inf 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.040864745349235 Inf 0.385544600126852 512 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 7.47775368279368e-05 1.89320152683959e-06 0.000416562561410248 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Ile335Val katG_p.Ile335Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 64 0 20782 27468 0.00307013335891777 0.0023651552036298 0.00391882408737535 1 0.999865711673152 1 1 0.943990910613363 1 NA NA NA NA NA NA NA NA NA NA 3147 5574 False False Inf 22.2726279264818 Inf 0 0 0.000177487829796209 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 47 0 13327 21313 0.00351428144160311 0.00258327005007396 0.00467054000892629 1 0.999826933785262 1 1 0.924514266308941 1 NA NA NA NA NA NA NA NA NA NA 2553 4479 False False 0 0 0 0 0 0 0 Inf 19.5789186635706 Inf 0 0 0.000276759132965034 1 0.999826933785262 1 5 3) Uncertain significance No change no 1 +Isoniazid katG p.Ile364Thr katG_p.Ile364Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 5 0 20841 27468 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 1 0.999865711673152 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 3352 5574 False False Inf 1.20760984683633 Inf 0 0 0.000176985413634466 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Isoniazid katG p.Ile393fs katG_p.Ile393fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 2 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.24748377190611 Inf 0.186150386160192 389.5 5574 False False Inf 0.544526627735454 Inf 9.59462700887503e-05 1.16197496419179e-05 0.000346547484278011 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.299330161198724 Inf 0.148637808646281 204 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0.000149555073655873 1.81123264336181e-05 0.000540138824607934 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change AwRI by relaxed thresholds (not endorsed) no G, O 1 +Isoniazid katG p.Ile393Ser katG_p.Ile393Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3057 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2484 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ile455fs katG_p.Ile455fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2955 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2405 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Ile455Leu katG_p.Ile455Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3353 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2711 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ile455Met katG_p.Ile455Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Ile462Met katG_p.Ile462Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Ile462Ser katG_p.Ile462Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3089 5574 False False Inf 0.869878292971449 Inf 0 0 0.000176976922618654 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Ile497Val katG_p.Ile497Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ile536fs katG_p.Ile536fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3369 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2723 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Ile563fs katG_p.Ile563fs 1 frameshift (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Ile666Met katG_p.Ile666Met 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3438 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2777 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Ile666Thr katG_p.Ile666Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3102 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ile71Ser katG_p.Ile71Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 2 2 20844 27466 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999927188000582 0.999737003036386 0.999991182007438 0.5 0.067585986488543 0.932414013511457 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.658846670504701 0.0111723913611586 12.657347321213 1 2027.5 5574 False False 1.3176933410094 0.0955278435529395 18.1762534351792 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ile80Phe katG_p.Ile80Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ile80Thr katG_p.Ile80Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3251 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ile8fs katG_p.Ile8fs 1 frameshift (see "Genomic_coordinates" sheet) 1 3 3 0 5 0 20841 27468 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 1 0.999865711673152 1 1 0.478176249895018 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.544578868503982 Inf 0.0803050031296393 277.5 5574 False False Inf 1.20760984683633 Inf 0.000143926309729418 2.9682048729561e-05 0.000420555567348889 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 4 0 13370 21313 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 1 0.999826933785262 1 1 0.397635364383525 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.299352559293419 Inf 0.148624148798733 200 4479 False False 0 0 0 0 0 0 0 Inf 1.05210128917758 Inf 0.000149566257852228 1.81136809684436e-05 0.000540179209988093 1 0.999826933785262 1 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change AwRI by relaxed thresholds (not endorsed) no G, O 1 +Isoniazid katG p.Ile8Val katG_p.Ile8Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Leu132Arg katG_p.Leu132Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3385 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2737 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 1 3) Uncertain significance No change no 1 +Isoniazid katG p.Leu132Pro katG_p.Leu132Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 1 0.025 1 1 0.025 1 Inf 0.0337891992100405 Inf 0.431445603576751 617.5 5574 False False Inf 0.544526627735454 Inf 4.79754365764728e-05 1.21463215353938e-06 0.000267272712750976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2437 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 1 3) Uncertain significance No change no 1 +Isoniazid katG p.Leu141Phe katG_p.Leu141Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 4 1 4 1 20842 27467 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999963594000291 0.999797175631493 0.999999078280314 0.8 0.28358206388191 0.994949236620532 0.8 0.28358206388191 0.994949236620532 0.8 0.28358206388191 0.994949236620532 5.27147106803569 0.521589398427432 259.279173455301 0.172849789839877 374 5574 False False 5.27147106803569 0.521589398427432 259.279173455301 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 4 0 4 0 13370 21313 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 1 0.999826933785262 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 1.05210128917758 Inf 0.0220931979488014 114 4479 False False 0 0 0 0 0 0 0 Inf 1.05210128917758 Inf 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 1 0.999826933785262 1 1 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Leu141Ser katG_p.Leu141Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 10 1 20836 27467 0.000479708337330902 0.000230061997553563 0.000882023176671562 0.999963594000291 0.999797175631493 0.999999078280314 0.909090909090909 0.587220083011617 0.997701027786185 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0337993200075976 Inf 0.431372143093739 600 5574 False False 13.1824726435016 1.87489573468025 570.603433894195 4.79915534865863e-05 1.21504019787923e-06 0.000267362490730224 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 0 1 4 1 13370 21312 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 0.999953080279641 0.999738608085756 0.999998812096234 0.8 0.28358206388191 0.994949236620532 0 0 0.975 0 0 0.975 0 0 62.1101953816142 1 1642.5 4479 False False 0 0 0 0 0 0 0 6.37606581899775 0.630846560224411 313.513380938872 0 0 0.000275869155324334 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Leu141Val katG_p.Leu141Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3035 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2469 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Leu147Ala katG_p.Leu147Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Leu147Arg katG_p.Leu147Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3439 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Leu159Phe katG_p.Leu159Phe 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3409 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2760 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Leu159Pro katG_p.Leu159Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Isoniazid katG p.Leu164Arg katG_p.Leu164Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Leu173fs katG_p.Leu173fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3148 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Leu205Arg katG_p.Leu205Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2994 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2438 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Leu220Pro katG_p.Leu220Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3499 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Leu265Arg katG_p.Leu265Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3480 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Leu298Phe katG_p.Leu298Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Leu298Ser katG_p.Leu298Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 1 0.025 1 1 0.025 1 Inf 0.0337908203661933 Inf 0.431433834944422 611 5574 False False Inf 0.869878292971449 Inf 4.79777383294151e-05 1.21469042880762e-06 0.000267285534484979 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 1 0.025 1 1 0.025 1 Inf 0.0408678013770354 Inf 0.385526884820527 489.5 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 7.47831289261142e-05 1.89334310623943e-06 0.000416593707936992 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Leu333Phe katG_p.Leu333Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3410 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2761 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Leu333Pro katG_p.Leu333Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.247471899512553 Inf 0.186160540855956 404 5574 False False Inf 0.247471899512553 Inf 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Leu336Met katG_p.Leu336Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.658815063564403 0.011171855707321 12.6567401482543 1 2027.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.59365886487699 0.0203005577541163 124.983813232444 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Leu343_Ser346delinsArg katG_p.Leu343_Ser346delinsArg 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Isoniazid katG p.Leu378Met katG_p.Leu378Met 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 5 0 20841 27468 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 1 0.999865711673152 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 3013 5574 False False Inf 1.20760984683633 Inf 0 0 0.000176985413634466 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 0 13370 21313 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 1 0.999826933785262 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2451 4479 False False 0 0 0 0 0 0 0 Inf 1.05210128917758 Inf 0 0 0.000275869155324334 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Leu378Pro katG_p.Leu378Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Isoniazid katG p.Leu382Arg katG_p.Leu382Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3036 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2470 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 2 3) Uncertain significance No change no 1 +Isoniazid katG p.Leu382fs katG_p.Leu382fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0337875782094303 Inf 0.431457371721896 645 5574 False False Inf 0.247471899512553 Inf 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Leu384Pro katG_p.Leu384Pro 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Leu398Arg katG_p.Leu398Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Leu427Arg katG_p.Leu427Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2712 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Leu427Phe katG_p.Leu427Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Leu427Pro katG_p.Leu427Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.247471899512553 Inf 0.186160540855956 404 5574 False False Inf 0.247471899512553 Inf 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain AwRI by relaxed thresholds (not endorsed) yes O 0 +Isoniazid katG p.Leu436Arg katG_p.Leu436Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance No change no 1 +Isoniazid katG p.Leu437Arg katG_p.Leu437Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Leu43Arg katG_p.Leu43Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3184 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2581 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Leu449Arg katG_p.Leu449Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Leu458Arg katG_p.Leu458Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.31767810026385 0.0167927522337569 103.35711725526 1 1253.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Leu458Ser katG_p.Leu458Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Leu472Pro katG_p.Leu472Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3342 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2704 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Leu48Gln katG_p.Leu48Gln 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3073 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Leu48Pro katG_p.Leu48Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.24748377190611 Inf 0.186150386160192 389.5 5574 False False Inf 0.544526627735454 Inf 9.59462700887503e-05 1.16197496419179e-05 0.000346547484278011 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.299307766452077 Inf 0.148651468333857 217.5 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Leu514Pro katG_p.Leu514Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Leu521Pro katG_p.Leu521Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Leu587Arg katG_p.Leu587Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3014 5574 False False Inf 0.869878292971449 Inf 0 0 0.000176976922618654 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2452 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Leu587Pro katG_p.Leu587Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 2 20844 27466 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999927188000582 0.999737003036386 0.999991182007438 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 51.3514785421127 1 2027.5 5574 False False 1.3176933410094 0.0955278435529395 18.1762534351792 0 0 0.000176959943030976 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2600 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance No change no 1 +Isoniazid katG p.Leu598Arg katG_p.Leu598Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Leu598Phe katG_p.Leu598Phe 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3328 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Leu604Phe katG_p.Leu604Phe 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2979 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2426 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Leu604Ser katG_p.Leu604Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3058 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Leu611Arg katG_p.Leu611Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3520 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2833 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 1 3) Uncertain significance No change no 1 +Isoniazid katG p.Leu616Ser katG_p.Leu616Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Leu627Pro katG_p.Leu627Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3252 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2633 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Leu631Gln katG_p.Leu631Gln 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3118 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2532 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Leu634Pro katG_p.Leu634Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Leu641_Gly644del katG_p.Leu641_Gly644del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Isoniazid katG p.Leu661Arg katG_p.Leu661Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Leu696fs katG_p.Leu696fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3314 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Leu696Gln katG_p.Leu696Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Leu704Trp katG_p.Leu704Trp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3521 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2834 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Leu704Val katG_p.Leu704Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 5 0 20841 27468 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 1 0.999865711673152 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 3500 5574 False False Inf 1.20760984683633 Inf 0 0 0.000176985413634466 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 5 0 13369 21313 0.000373859727830118 0.000121402023062639 0.000872246401868143 1 0.999826933785262 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 2817 4479 False False 0 0 0 0 0 0 0 Inf 1.46057233596553 Inf 0 0 0.000275889787465637 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Leu707Arg katG_p.Leu707Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 20846 27462 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.11900921779861 0.0402109359097128 194.5 5574 False False 0 0 1.11900921779861 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 13374 21307 0 0 0.000275786657608973 0.999718481677849 0.999387354605726 0.999896680954833 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.35335561005417 0.0884814409570568 164 4479 False False 0 0 0 0 0 0 0 0 0 1.35335561005417 0 0 0.000275786657608973 0.999718481677849 0.999387354605726 0.999896680954833 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Leu707Pro katG_p.Leu707Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Leu734Arg katG_p.Leu734Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3059 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2485 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Leu734Val katG_p.Leu734Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3354 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2713 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Leu76Pro katG_p.Leu76Pro 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Lys143Asn katG_p.Lys143Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Lys143Gln katG_p.Lys143Gln 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3481 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2808 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Lys143Glu katG_p.Lys143Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3440 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2778 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Lys143Thr katG_p.Lys143Thr 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Lys152Gln katG_p.Lys152Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Lys152Thr katG_p.Lys152Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3074 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2496 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Lys153Asn katG_p.Lys153Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3132 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Lys153Gln katG_p.Lys153Gln 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3281 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2653 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Lys153Glu katG_p.Lys153Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2995 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2439 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Lys154dup katG_p.Lys154dup 1 inframe_insertion (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3370 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2724 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Isoniazid katG p.Lys157Asn katG_p.Lys157Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3282 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2654 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Lys157fs katG_p.Lys157fs 1 frameshift (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Lys158Glu katG_p.Lys158Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Lys179fs katG_p.Lys179fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3501 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2818 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Lys200Arg katG_p.Lys200Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Lys200fs katG_p.Lys200fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3037 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Lys200Glu katG_p.Lys200Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3482 5574 False False Inf 0.869878292971449 Inf 0 0 0.000176976922618654 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Lys310Asn katG_p.Lys310Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3038 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2471 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Lys345Asn katG_p.Lys345Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Lys433fs katG_p.Lys433fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0337875782094303 Inf 0.431457371721896 645 5574 False False Inf 0.247471899512553 Inf 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.040864745349235 Inf 0.385544600126852 512 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 7.47775368279368e-05 1.89320152683959e-06 0.000416562561410248 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Lys433Thr katG_p.Lys433Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 3 5 20843 27463 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999817970001456 0.999575254267103 0.999940892797913 0.375 0.0852334141372535 0.755136783633448 0 0 0.602364635616474 0 0 0.521823750104981 0 0 1.99626245403242 0.139128945561676 351 5574 False False 0.790567576644437 0.122780413850952 4.06394022809159 0 0 0.00017696843241753 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2616 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 3 3) Uncertain significance No change no 1 +Isoniazid katG p.Lys459fs katG_p.Lys459fs 1 frameshift (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Lys459Glu katG_p.Lys459Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3039 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Lys459Thr katG_p.Lys459Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Lys46Asn katG_p.Lys46Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3212 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2601 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Lys46fs katG_p.Lys46fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3230 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2617 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Lys46Glu katG_p.Lys46Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3441 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2779 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Lys488Asn katG_p.Lys488Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3329 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2694 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Lys488Glu katG_p.Lys488Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2956 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Lys516Arg katG_p.Lys516Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3264 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2639 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Lys537Glu katG_p.Lys537Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Lys554Asn katG_p.Lys554Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Lys557Arg katG_p.Lys557Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2996 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2440 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 4 3) Uncertain significance No change no 1 +Isoniazid katG p.Lys557Asn katG_p.Lys557Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 11 0 11 6 12 20840 27456 0.000287825002398541 0.000105633792978048 0.000626367784710498 0.999563128003495 0.99923699702714 0.999774242139628 0.333333333333333 0.133427402506123 0.590074761827925 0 0 0.284914152918154 0 0 0.264648469397051 0 0 0.525001292991211 0.00349784775921307 105 5574 False False 0.65873320537428 0.202834119084116 1.89684355523546 0 0 0.000176993905465082 0.999563128003495 0.99923699702714 0.999774242139628 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 6 11 13368 21302 0.000448631673396141 0.000164657143425453 0.000976224581517196 0.999483883076056 0.999076712346733 0.999742329032819 0.352941176470588 0.14209748311022 0.616716336556597 0 0 0.30849710781876 0 0 0.284914152918154 0 0 0.711051360387429 0.0089006014870235 80 4479 False False 0 0 0 0 0 0 0 0.869185572058103 0.263900543195497 2.56479256902207 0 0 0.00027591042269331 0.999483883076056 0.999076712346733 0.999742329032819 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Lys557fs katG_p.Lys557fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3411 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Lys590fs katG_p.Lys590fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3522 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Lys590Gln katG_p.Lys590Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Lys600Gln katG_p.Lys600Gln 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3330 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2695 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Lys681Thr katG_p.Lys681Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Lys686Glu katG_p.Lys686Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3103 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2520 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Lys719Gln katG_p.Lys719Gln 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3133 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2541 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Lys730Asn katG_p.Lys730Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Met1? katG_p.Met1? 1 start_lost (see "Genomic_coordinates" sheet) 1 24 24 0 29 0 20817 27468 0.00139115417825961 0.000931869577538548 0.00199732323166199 1 0.999865711673152 1 1 0.880555130930497 1 1 0.857526402277474 1 1 0.857526402277474 1 Inf 7.94228264800277 Inf 1.71435273946543e-09 18 5574 True False Inf 9.724633441073 Inf 0.00115157621995105 0.000737971604671233 0.00171297271678467 1 0.999865711673152 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 16 16 0 20 0 13354 21313 0.00149543891132047 0.000913684725149316 0.00230864386780147 1 0.999826933785262 1 1 0.831566529016914 1 1 0.794092785792177 1 1 0.794092785792177 1 Inf 6.15243071025102 Inf 2.36504509770735e-07 16 4479 True False 0 0 0 0 0 0 0 Inf 7.87776979048218 Inf 0.00119670905011219 0.000684172454560627 0.00194265496793158 1 0.999826933785262 1 NA 1) Assoc w R High-level resistance UP from AwRI to AwR yes G 4 +Isoniazid katG p.Met105Ile katG_p.Met105Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 6 2 20840 27466 0.000287825002398541 0.000105633792978048 0.000626367784710498 0.999927188000582 0.999737003036386 0.999991182007438 0.75 0.349144205587175 0.968145973750055 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01800871086406 0.509402168813005 1202 5574 False False 3.95383877159309 0.706870204411237 40.0621427029589 0 0 0.000176993905465082 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 6 2 13368 21311 0.000448631673396141 0.000164657143425453 0.000976224581517196 0.999906160559283 0.999661061221376 0.999988635406343 0.75 0.349144205587175 0.968145973750055 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48916031692888 0.526226988861106 976 4479 False False 0 0 0 0 0 0 0 4.78254039497307 0.854982288254785 48.451322625226 0 0 0.00027591042269331 0.999906160559283 0.999661061221376 0.999988635406343 1 3) Uncertain significance No change no 1 +Isoniazid katG p.Met126Ile katG_p.Met126Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 3 2 20843 27466 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999927188000582 0.999737003036386 0.999991182007438 0.6 0.146632799634673 0.947255049473683 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01699856622015 0.509392482788101 1176.5 5574 False False 1.97663484143357 0.226402568392661 23.6672561646805 0 0 0.00017696843241753 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2427 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 1 3) Uncertain significance No change no 1 +Isoniazid katG p.Met126Val katG_p.Met126Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3149 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Met176Ile katG_p.Met176Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3134 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Met176Thr katG_p.Met176Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3523 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2835 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Met225Ile katG_p.Met225Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3119 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2533 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 2 3) Uncertain significance No change no 1 +Isoniazid katG p.Met225Val katG_p.Met225Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3253 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2634 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Met242Ile katG_p.Met242Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Met242Thr katG_p.Met242Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3412 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2762 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Met257Ile katG_p.Met257Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 9 1 20837 27467 0.000431737503597812 0.000197436276106449 0.000819413341228355 0.999963594000291 0.999797175631493 0.999999078280314 0.9 0.554983882971804 0.997471421455538 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.033797697976772 Inf 0.431383914708622 601 5574 False False 11.8636559965446 1.6436266007203 518.765276537541 4.79892504079086e-05 1.21498188904634e-06 0.000267349661612127 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 0 1 7 1 13367 21312 0.000523403618962165 0.000210460468745924 0.00107811225334149 0.999953080279641 0.999738608085756 0.999998812096234 0.875 0.473490329124793 0.996840276468748 0 0 0.975 0 0 0.975 0 0 62.1241214470754 1 1642.5 4479 False False 0 0 0 0 0 0 0 11.1606194359242 1.43348631137374 501.805825213892 0 0 0.000275931061008045 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Met257Thr katG_p.Met257Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Met26fs katG_p.Met26fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3040 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2472 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Met296Ile katG_p.Met296Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3185 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2582 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Met296Val katG_p.Met296Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3371 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2725 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Met377Arg katG_p.Met377Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2957 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2406 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Met377Thr katG_p.Met377Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3413 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Met420Ile katG_p.Met420Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Met58Val katG_p.Met58Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3524 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Met609Ile katG_p.Met609Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3075 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2497 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Met609Thr katG_p.Met609Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Met624fs katG_p.Met624fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3231 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Met624Ile katG_p.Met624Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3386 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2738 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 1 3) Uncertain significance No change no 1 +Isoniazid katG p.Met624Val katG_p.Met624Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3442 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2780 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 3 3) Uncertain significance No change no 1 +Isoniazid katG p.Met84Ile katG_p.Met84Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Met84Leu katG_p.Met84Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Met84Thr katG_p.Met84Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3135 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Met84Val katG_p.Met84Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3462 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2795 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Phe129Ser katG_p.Phe129Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0337875782094303 Inf 0.431457371721896 645 5574 False False Inf 0.247471899512553 Inf 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.040864745349235 Inf 0.385544600126852 512 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 7.47775368279368e-05 1.89320152683959e-06 0.000416562561410248 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Phe167Cys katG_p.Phe167Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 11 0 20835 27468 0.000527679171063993 0.000263444034397523 0.000943967185544106 1 0.999865711673152 1 1 0.715085847081845 1 NA NA NA NA NA NA NA NA NA NA 3265 5574 False False Inf 3.30816067473776 Inf 0 0 0.000177036376844338 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2640 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Phe178Val katG_p.Phe178Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Phe183Leu katG_p.Phe183Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 1 0.025 1 1 0.025 1 Inf 0.0337891992100405 Inf 0.431445603576751 617.5 5574 False False Inf 0.544526627735454 Inf 4.79754365764728e-05 1.21463215353938e-06 0.000267272712750976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.040864745349235 Inf 0.385544600126852 512 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 7.47775368279368e-05 1.89320152683959e-06 0.000416562561410248 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Phe183Ser katG_p.Phe183Ser 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Phe252Leu katG_p.Phe252Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3041 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Phe272fs katG_p.Phe272fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Phe272Leu katG_p.Phe272Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3443 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2781 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Phe332Val katG_p.Phe332Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Phe368Leu katG_p.Phe368Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3232 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2618 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Phe408Leu katG_p.Phe408Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3254 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Phe483Leu katG_p.Phe483Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Phe483Ser katG_p.Phe483Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3120 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Phe540Ser katG_p.Phe540Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 1 0.025 1 1 0.025 1 Inf 0.0337891992100405 Inf 0.431445603576751 617.5 5574 False False Inf 0.544526627735454 Inf 4.79754365764728e-05 1.21463215353938e-06 0.000267272712750976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 1 0.025 1 1 0.025 1 Inf 0.0408678013770354 Inf 0.385526884820527 489.5 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 7.47831289261142e-05 1.89334310623943e-06 0.000416593707936992 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Phe567Ser katG_p.Phe567Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3343 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Phe567Tyr katG_p.Phe567Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2997 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Phe584Val katG_p.Phe584Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 0 9 4 9 20842 27459 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999672346002621 0.99937810218515 0.999850165132458 0.307692307692307 0.0909203945720966 0.614261661750705 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.66757682448829 0.0128614947442288 136 5574 False False 0.585548411860666 0.13173108052869 2.09838247392389 0 0 0.000176976922618654 0.999672346002621 0.99937810218515 0.999850165132458 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 2 7 13372 21306 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.99967156195749 0.999323409938814 0.999867941002665 0.222222222222222 0.0281449734778982 0.600093573716312 0 0 0.409616397225003 0 0 0.409616397225003 0 0 1.10569046179069 0.0484443885645212 136 4479 False False 0 0 0 0 0 0 0 0.455236955685654 0.0461387128464925 2.39147917078199 0 0 0.000275827900298067 0.99967156195749 0.999323409938814 0.999867941002665 1 3) Uncertain significance No change no 1 +Isoniazid katG p.Phe594Ile katG_p.Phe594Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2980 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2428 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Phe594Leu katG_p.Phe594Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3060 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Phe62Leu katG_p.Phe62Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 1 20843 27467 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999963594000291 0.999797175631493 0.999999078280314 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 3266 5574 False False 3.95341361608213 0.31739219148065 207.323829234655 0 0 0.00017696843241753 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Isoniazid katG p.Phe62Ser katG_p.Phe62Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3233 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2619 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Phe658Leu katG_p.Phe658Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Phe658Val katG_p.Phe658Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2981 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Phe698Leu katG_p.Phe698Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2982 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2429 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Phe724Leu katG_p.Phe724Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3042 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2473 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Pro131Gln katG_p.Pro131Gln 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3525 5574 False False Inf 0.869878292971449 Inf 0 0 0.000176976922618654 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Pro131Ser katG_p.Pro131Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01632529799099 0.509386028876591 1135.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Pro136Leu katG_p.Pro136Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 51.3533466119536 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 62.1009148060541 1 1642.5 4479 False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 0 0 0.000275827900298067 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Pro150Ser katG_p.Pro150Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3136 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2542 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Pro232Ala katG_p.Pro232Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 3 0 5 0 20841 27468 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 1 0.999865711673152 1 1 0.478176249895018 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.544578868503982 Inf 0.0803050031296393 277.5 5574 False False Inf 1.20760984683633 Inf 0.000143926309729418 2.9682048729561e-05 0.000420555567348889 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 2 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Pro232Arg katG_p.Pro232Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Pro232Leu katG_p.Pro232Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3137 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2543 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Pro232Ser katG_p.Pro232Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 2 1 13 1 20833 27467 0.000623620838530173 0.000332092285535748 0.00106617452923529 0.999963594000291 0.999797175631493 0.999999078280314 0.928571428571428 0.661315510068178 0.998193219340874 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 2.63687418998703 0.137255845633605 155.431465593512 0.581536401692855 1220 5574 False False 17.1396822349157 2.57388324724397 725.995291467278 9.59923206143508e-05 1.16253267770098e-05 0.000346713792909302 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 4 0 13370 21313 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 1 0.999826933785262 1 1 0.397635364383525 1 1 0.025 1 1 0.025 1 Inf 0.0408708578619459 Inf 0.385509168492676 483 4479 False False 0 0 0 0 0 0 0 Inf 1.05210128917758 Inf 7.47887218607434e-05 1.89348470681633e-06 0.000416624859121756 1 0.999826933785262 1 1 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Pro235Ser katG_p.Pro235Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2958 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2407 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Pro241His katG_p.Pro241His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Pro280Ser katG_p.Pro280Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 7 9 20839 27459 0.000335795836131632 0.000135017659185429 0.000691744589626827 0.999672346002621 0.99937810218515 0.999850165132458 0.4375 0.197534140532667 0.701223100916822 0 0 0.409616397225003 0 0 0.336267116879942 0 0 0.914361633162461 0.0219872656339211 168 5574 False False 1.02485723883103 0.324290493334449 3.09312242943178 0 0 0.00017700239811062 0.999672346002621 0.99937810218515 0.999850165132458 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 7 8 13367 21305 0.000523403618962165 0.000210460468745924 0.00107811225334149 0.999624642237132 0.999260530264256 0.999837933676441 0.466666666666666 0.212666729519307 0.734138652722603 0 0 0.409616397225003 0 0 0.369416647552819 0 0 1.10605216133435 0.0484565668054678 139 4479 False False 0 0 0 0 0 0 0 1.39461921149098 0.430375114744886 4.40232345408191 0 0 0.000275931061008045 0.999624642237132 0.999260530264256 0.999837933676441 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Pro286Ala katG_p.Pro286Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Pro286His katG_p.Pro286His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3502 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Pro286Leu katG_p.Pro286Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Pro288_Glu289del katG_p.Pro288_Glu289del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Isoniazid katG p.Pro288His katG_p.Pro288His 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.247471899512553 Inf 0.186160540855956 404 5574 False False Inf 0.247471899512553 Inf 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.299307766452077 Inf 0.148651468333857 217.5 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain AwRI by relaxed thresholds (not endorsed) yes O 0 +Isoniazid katG p.Pro288Leu katG_p.Pro288Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3463 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2796 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Pro29_Val30delinsLeu katG_p.Pro29_Val30delinsLeu 1 inframe_deletion (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3268 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Isoniazid katG p.Pro292Ala katG_p.Pro292Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3267 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2641 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Pro29Ser katG_p.Pro29Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 6 0 20840 27468 0.000287825002398541 0.000105633792978048 0.000626367784710498 1 0.999865711673152 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 3414 5574 False False Inf 1.55167078958407 Inf 0 0 0.000176993905465082 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2763 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Pro2Ser katG_p.Pro2Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3444 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Pro325fs katG_p.Pro325fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3150 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2554 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Pro325Ser katG_p.Pro325Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3138 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Pro325Thr katG_p.Pro325Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Pro347Ser katG_p.Pro347Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Pro365Thr katG_p.Pro365Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3121 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2534 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Pro367Leu katG_p.Pro367Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3015 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Pro401Leu katG_p.Pro401Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3415 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2764 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Pro40Leu katG_p.Pro40Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Pro422fs katG_p.Pro422fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.247471899512553 Inf 0.186160540855956 404 5574 False False Inf 0.247471899512553 Inf 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.299307766452077 Inf 0.148651468333857 217.5 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change AwRI by relaxed thresholds (not endorsed) no G, O 1 +Isoniazid katG p.Pro422His katG_p.Pro422His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Pro429Arg katG_p.Pro429Arg 1 missense_variant (see "Genomic_coordinates" sheet) 2 2 0 2 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01632529799099 0.509386028876591 1135.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 2 0 2 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48598624162872 0.526186417038858 925 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Pro429del katG_p.Pro429del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.247471899512553 Inf 0.186160540855956 404 5574 False False Inf 0.247471899512553 Inf 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.299307766452077 Inf 0.148651468333857 217.5 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 NA 3) Uncertain significance DOWN from AwRI to Uncertain AwRI by relaxed thresholds (not endorsed) yes O 2 +Isoniazid katG p.Pro429fs katG_p.Pro429fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Pro432Leu katG_p.Pro432Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 5 1 20841 27467 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.999963594000291 0.999797175631493 0.999999078280314 0.833333333333333 0.358765421002325 0.99578925548551 NA NA NA 0 0 0.975 NA NA NA NA 3043 5574 False False 6.58965500695744 0.737267067818355 311.215258952954 0 0 0.000176985413634466 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 1 13371 21312 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999953080279641 0.999738608085756 0.999998812096234 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 2474 4479 False False 0 0 0 0 0 0 0 4.78169172088849 0.383875689805931 250.696170545132 0 0 0.000275848526268708 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Pro432Thr katG_p.Pro432Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Pro510Ala katG_p.Pro510Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Pro52Arg katG_p.Pro52Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3526 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2836 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Pro52Ser katG_p.Pro52Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Pro533Leu katG_p.Pro533Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 1 3) Uncertain significance No change no 1 +Isoniazid katG p.Pro566Leu katG_p.Pro566Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance No change no 1 +Isoniazid katG p.Pro566Ser katG_p.Pro566Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Pro569fs katG_p.Pro569fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Pro569Leu katG_p.Pro569Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Pro57Ser katG_p.Pro57Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2998 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2441 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Pro605Arg katG_p.Pro605Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance No change no 1 +Isoniazid katG p.Pro622fs katG_p.Pro622fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3090 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2510 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Pro642fs katG_p.Pro642fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3213 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Pro672Ser katG_p.Pro672Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Pro6fs katG_p.Pro6fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Pro6Ser katG_p.Pro6Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 14 0 14 4 15 20842 27453 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999453910004368 0.999099467294252 0.999694326386446 0.210526315789473 0.0605245377092897 0.455653081891505 0 0 0.231635761650116 0 0 0.218019360910534 0 0 0.397131042649259 0.000518686198760768 68 5574 True False 0.351252279051914 0.0848199680188957 1.10281717449179 0 0 0.000176976922618654 0.999453910004368 0.999099467294252 0.999694326386446 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 13 0 13 3 14 13371 21299 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999343123914981 0.998898118907794 0.999640834680135 0.176470588235294 0.0379850680706259 0.434317872844283 0 0 0.24705263800047 0 0 0.231635761650116 0 0 0.52277696910171 0.00269009293140298 62 4479 False False 0 0 0 0 0 0 0 0.341341068623994 0.0628905215833431 1.22336182693063 0 0 0.000275848526268708 0.999343123914981 0.998898118907794 0.999640834680135 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Pro718Ser katG_p.Pro718Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 13 0 13 0 13 20846 27455 0 0 0.00017694296670111 0.999526722003786 0.99919081619501 0.999747976101462 0 0 0.24705263800047 0 0 0.24705263800047 0 0 0.24705263800047 0 0 0.432228279580125 0.000972668331678132 74 5574 False False 0 0 0.432228279580125 0 0 0.00017694296670111 0.999526722003786 0.99919081619501 0.999747976101462 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 13 0 13 0 13 13374 21300 0 0 0.000275786657608973 0.99939004363534 0.998957181904114 0.999675185224884 0 0 0.24705263800047 0 0 0.24705263800047 0 0 0.24705263800047 0 0 0.522684266329562 0.00268949884736775 60 4479 False False 0 0 0 0 0 0 0 0 0 0.522684266329562 0 0 0.000275786657608973 0.99939004363534 0.998957181904114 0.999675185224884 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Pro7fs katG_p.Pro7fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3445 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2782 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Pro92Ser katG_p.Pro92Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3091 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2511 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Ser140Arg katG_p.Ser140Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Ser140Asn katG_p.Ser140Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 14 6 20832 27462 0.000671591672263264 0.000367212509754494 0.00112656023057506 0.999781564001747 0.999524617886493 0.999919833755107 0.7 0.45721081772371 0.881068409594272 NA NA NA 0 0 0.4592581264399 NA NA NA NA 3234 5574 False False 3.07594086021505 1.11015950370925 9.76472101172182 0 0 0.000177061869457058 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 5 4 13369 21309 0.000373859727830118 0.000121402023062639 0.000872246401868143 0.999812321118566 0.999519537882235 0.999948861529775 0.555555555555555 0.212008506778868 0.863004337734833 NA NA NA 0 0 0.602364635616474 NA NA NA NA 2620 4479 False False 0 0 0 0 0 0 0 1.99238910913306 0.428746116317097 10.0429456178996 0 0 0.000275889787465637 0.999812321118566 0.999519537882235 0.999948861529775 1 3) Uncertain significance No change no 1 +Isoniazid katG p.Ser140Gly katG_p.Ser140Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3464 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2797 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ser160Pro katG_p.Ser160Pro 1 missense_variant (see "Genomic_coordinates" sheet) 2 2 2 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.247471899512553 Inf 0.186160540855956 404 5574 False False Inf 0.247471899512553 Inf 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 2 2 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.299307766452077 Inf 0.148651468333857 217.5 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain AwRI by relaxed thresholds (not endorsed) yes O 0 +Isoniazid katG p.Ser175* katG_p.Ser175* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Ser17Gly katG_p.Ser17Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ser211Asn katG_p.Ser211Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 2 4 20844 27464 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999854376001165 0.999627187086024 0.999960320981843 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.602364635616474 0 0 0.602364635616474 0 0 1.99623938970482 0.139127771476516 349 5574 False False 0.658798695068125 0.0595601499680727 4.59736120623929 0 0 0.000176959943030976 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 2 3 13372 21310 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999859240838924 0.999588697652472 0.999970971136275 0.4 0.0527449505263169 0.853367200365326 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85709530412199 0.289291791934617 400.5 4479 False False 0 0 0 0 0 0 0 1.06241898494366 0.0886985485353837 9.27715037564111 0 0 0.000275827900298067 0.999859240838924 0.999588697652472 0.999970971136275 1 3) Uncertain significance No change no 1 +Isoniazid katG p.Ser302Arg katG_p.Ser302Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 7 1 20839 27467 0.000335795836131632 0.000135017659185429 0.000691744589626827 0.999963594000291 0.999797175631493 0.999999078280314 0.875 0.473490329124793 0.996840276468748 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0337944543821121 Inf 0.431407456476287 606 5574 False False 9.22640241854215 1.18513781610454 415.029346412368 4.79846449136276e-05 1.21486528816812e-06 0.000267324007069132 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 7 1 13367 21312 0.000523403618962165 0.000210460468745924 0.00107811225334149 0.999953080279641 0.999738608085756 0.999998812096234 0.875 0.473490329124793 0.996840276468748 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0408781119592846 Inf 0.385467128027681 478 4479 False False 0 0 0 0 0 0 0 11.1606194359242 1.43348631137374 501.805825213892 7.48055056852184e-05 1.89390963565694e-06 0.000416718340634631 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ser302fs katG_p.Ser302fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3104 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Ser315Arg katG_p.Ser315Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 12 12 0 14 1 20832 27467 0.000671591672263264 0.000367212509754494 0.00112656023057506 0.999963594000291 0.999797175631493 0.999999078280314 0.933333333333333 0.680515433421696 0.998313569758647 1 0.735351530602948 1 0.923076923076923 0.639702564732122 0.998054371502653 Inf 3.66322043087533 Inf 4.15373142639815e-05 54 5574 True False 18.459005376344 2.80796092158034 777.750664330232 0.000575705238917674 0.00029750955315669 0.00100542501554565 0.999963594000291 0.999797175631493 0.999999078280314 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 10 10 0 10 0 13364 21313 0.000747719455660236 0.000358616922835118 0.00137465137870696 1 0.999826933785262 1 1 0.691502892181239 1 1 0.691502892181239 1 1 0.691502892181239 1 Inf 3.57391601991246 Inf 7.24515399811682e-05 35 4479 True False 0 0 0 0 0 0 0 Inf 3.57391601991246 Inf 0.000747719455660236 0.000358616922835118 0.00137465137870696 1 0.999826933785262 1 NA Marker of R 1) Assoc w R High-level resistance UP from Uncertain to AwR yes G 4 +Isoniazid katG p.Ser315Asn katG_p.Ser315Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 129 128 1 206 5 20640 27463 0.00988199174901659 0.00858393006872336 0.0113193346943433 0.999817970001456 0.999575254267103 0.999940892797913 0.976303317535545 0.945569175365454 0.992261990313721 0.992248062015504 0.9575665749347 0.999803757180744 0.962406015037594 0.914449592621806 0.987682545016036 170.313178294573 30.0252123536006 6502.79235323934 8.55521415641651e-46 4 5574 True False 54.8195542635658 23.1047561497696 169.916065920855 0.0061633281972265 0.0051444240636736 0.0073239443396762 0.999817970001456 0.999575254267103 0.999940892797913 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 81 80 1 120 3 13254 21310 0.00897263346792283 0.0074446456588826 0.0107196326808887 0.999859240838924 0.999588697652472 0.999970971136275 0.975609756097561 0.93037547352015 0.994941622782186 0.987654320987654 0.933124379067789 0.999687483312846 0.963855421686747 0.897985117664238 0.992483179764803 128.625320657914 22.4268719593874 4992.04863725425 2.90991194673967e-32 4 4479 True False 0 0 0 0 0 0 0 64.3126603289572 21.4803403086595 318.477376783335 0.00599970001499925 0.00476017104595577 0.00746166192337993 0.999859240838924 0.999588697652472 0.999970971136275 9 Assoc w R Assoc w R Marker of R 1) Assoc w R High-level resistance No change yes G 1 +Isoniazid katG p.Ser315Gly katG_p.Ser315Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 2 1 29 1 20817 27467 0.00139115417825961 0.000931869577538548 0.00199732323166199 0.999963594000291 0.999797175631493 0.999999078280314 0.966666666666666 0.827830544366587 0.999156429073369 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 2.63890089830427 0.137361343623476 155.55080762611 0.581441952708203 1219 5574 False False 38.2640630254119 6.34278910249726 1551.32518770529 9.60660934723089e-05 1.16342613374501e-05 0.000346980218991374 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 21 0 13353 21313 0.00157021085688649 0.000972239812025402 0.00239923787401666 1 0.999826933785262 1 1 0.83890238478092 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.299733839882761 Inf 0.148391906954032 197 4479 False False 0 0 0 0 0 0 0 Inf 8.30942270480458 Inf 0.000149756645451141 1.81367390974988e-05 0.000540866686610565 1 0.999826933785262 1 7 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Ser315Ile katG_p.Ser315Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 11 11 0 20 0 20826 27468 0.000959416674661805 0.000586132014909014 0.00148135424594851 1 0.999865711673152 1 1 0.831566529016914 1 1 0.715085847081845 1 1 0.715085847081845 1 Inf 3.30958707070725 Inf 9.60776014961372e-05 60 5574 True False Inf 6.51017121398754 Inf 0.00052790708835245 0.000263557834508622 0.000944374822652719 1 0.999865711673152 1 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance 1 6 6 0 11 0 13363 21313 0.000822491401226259 0.000410653977896139 0.00147118664271154 1 0.999826933785262 1 1 0.715085847081845 1 1 0.540741873560099 1 1 0.540741873560099 1 Inf 1.87752085958725 Inf 0.0032784550564454 65 4479 False False 0 0 0 0 0 0 0 Inf 4.00162721599209 Inf 0.000448799461440646 0.000164718731569378 0.000976589592664291 1 0.999826933785262 1 3 Marker of R Evidence from ALL dataset only 2) Assoc w R - Interim High-level resistance UP from Uncertain to AwRI AwRI by relaxed thresholds (not endorsed) yes ALL only G, O 4 +Isoniazid katG p.Ser315Thr katG_p.Ser315Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 11349 11153 196 16302 250 4649 27505 0.77810128394826 0.77241250024962 0.783712803978559 0.990992613943433 0.989810152071645 0.992070497372297 0.984896085065249 0.982920200044254 0.986698781552574 0.982729755925632 0.980161200491146 0.985046182975035 0.978075944926773 0.975219104274974 0.980684921850033 336.657065816216 291.900242994638 390.221594776714 0 1.5 5574 True False 385.791791783179 333.537698265888 436.533536707814 0.705796734590558 0.698622809075138 0.71289483470203 0.990992613943433 0.989810152071645 0.992070497372297 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 7294 7188 106 10417 137 3004 21323 0.776171671261455 0.769023271170489 0.783200135748624 0.993616029822926 0.99245749660585 0.994637611019997 0.987019139662687 0.984672686805029 0.98909083633455 0.985467507540444 0.982450189501791 0.988087060685627 0.981296928327645 0.977927705258332 0.984274920924356 481.338479511594 393.473306338731 600.242546711621 0 1 4479 True False 0 0 0 0 0 0 0 539.722440638759 455.100034808043 632.939212475295 0.705259026687598 0.696300790719099 0.714099846052764 0.993616029822926 0.99245749660585 0.994637611019997 1932 Assoc w R Assoc w R Marker of R 1) Assoc w R High-level resistance No change yes G 1 +Isoniazid katG p.Ser331Gly katG_p.Ser331Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3283 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ser331Ile katG_p.Ser331Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3355 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ser383Pro katG_p.Ser383Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3186 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2583 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Ser383Trp katG_p.Ser383Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ser446Asn katG_p.Ser446Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 20846 27462 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.11900921779861 0.0402109359097128 194.5 5574 False False 0 0 1.11900921779861 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ser457Gly katG_p.Ser457Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 0 8 20846 27460 0 0 0.00017694296670111 0.99970875200233 0.999426206431739 0.999874251669172 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.771808536885009 0.0121106507453556 124 5574 False False 0 0 0.771808536885009 0 0 0.00017694296670111 0.99970875200233 0.999426206431739 0.999874251669172 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 13374 21308 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.73894646374006 0.163960020972012 248.5 4479 False False 0 0 0 0 0 0 0 0 0 1.73894646374006 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ser457Ile katG_p.Ser457Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3187 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2584 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ser460Asn katG_p.Ser460Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3372 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2726 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Ser465Pro katG_p.Ser465Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2999 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2442 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Ser474Gln katG_p.Ser474Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Ser474Pro katG_p.Ser474Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2983 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2430 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ser481Ala katG_p.Ser481Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ser481Leu katG_p.Ser481Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0337847273324512 Inf 0.431478070084656 825 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0408597725378736 Inf 0.385573430202387 666 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ser482Pro katG_p.Ser482Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3527 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ser486Asn katG_p.Ser486Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3214 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2602 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Ser527Leu katG_p.Ser527Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ser539fs katG_p.Ser539fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Ser620Arg katG_p.Ser620Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Ser650fs katG_p.Ser650fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3483 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Ser650Phe katG_p.Ser650Phe 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3235 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2621 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ser652Ala katG_p.Ser652Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Ser652fs katG_p.Ser652fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2959 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2408 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Ser652Pro katG_p.Ser652Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3188 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2585 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ser671* katG_p.Ser671* 1 stop_gained (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3416 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2765 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Ser684Arg katG_p.Ser684Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ser692Arg katG_p.Ser692Arg 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ser700Phe katG_p.Ser700Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ser700Pro katG_p.Ser700Pro 1 missense_variant (see "Genomic_coordinates" sheet) 2 2 2 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.247471899512553 Inf 0.186160540855956 404 5574 False False Inf 0.247471899512553 Inf 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 2 2 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.299307766452077 Inf 0.148651468333857 217.5 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 NA 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Ser87Leu katG_p.Ser87Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Ter741Argext*? katG_p.Ter741Argext*? 1 stop_lost (see "Genomic_coordinates" sheet) 1 1 1 0 6 0 20840 27468 0.000287825002398541 0.000105633792978048 0.000626367784710498 1 0.999865711673152 1 1 0.540741873560099 1 1 0.025 1 1 0.025 1 Inf 0.0337940631452161 Inf 0.431410296218095 607.5 5574 False False Inf 1.55167078958407 Inf 4.79823424979607e-05 1.21480699612118e-06 0.000267311181643879 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2498 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Ter741Trpext*? katG_p.Ter741Trpext*? 1 stop_lost (see "Genomic_coordinates" sheet) 1 1 1 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 1 0.025 1 1 0.025 1 Inf 0.0337891992100405 Inf 0.431445603576751 617.5 5574 False False Inf 0.544526627735454 Inf 4.79754365764728e-05 1.21463215353938e-06 0.000267272712750976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.040864745349235 Inf 0.385544600126852 512 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 7.47775368279368e-05 1.89320152683959e-06 0.000416562561410248 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Thr112Ser katG_p.Thr112Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Thr11Ala katG_p.Thr11Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3122 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Thr11Ser katG_p.Thr11Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Thr12Ala katG_p.Thr12Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Thr180Met katG_p.Thr180Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Thr203fs katG_p.Thr203fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Thr251Pro katG_p.Thr251Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0337875782094303 Inf 0.431457371721896 645 5574 False False Inf 0.247471899512553 Inf 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.040864745349235 Inf 0.385544600126852 512 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 7.47775368279368e-05 1.89320152683959e-06 0.000416562561410248 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Thr271Ala katG_p.Thr271Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3105 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2521 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 1 3) Uncertain significance No change no 1 +Isoniazid katG p.Thr271Ile katG_p.Thr271Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 3 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.544552746865154 Inf 0.0803115749774769 281 5574 False False Inf 0.869878292971449 Inf 0.000143919405133125 2.96806247414452e-05 0.000420535394770913 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 3 0 4 0 13370 21313 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 1 0.999826933785262 1 1 0.397635364383525 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.658622746210869 Inf 0.0573012380178015 143 4479 False False 0 0 0 0 0 0 0 Inf 1.05210128917758 Inf 0.00022433261048381 4.62651669632347e-05 0.00065545373138314 1 0.999826933785262 1 NA 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Thr271Pro katG_p.Thr271Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.24748377190611 Inf 0.186150386160192 389.5 5574 False False Inf 0.544526627735454 Inf 9.59462700887503e-05 1.16197496419179e-05 0.000346547484278011 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.299307766452077 Inf 0.148651468333857 217.5 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 NA 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Thr275Ala katG_p.Thr275Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 33 0 20813 27468 0.00158303751319197 0.00108993298100569 0.00222246155345815 1 0.999865711673152 1 1 0.89423718992542 1 NA NA NA NA NA NA NA NA NA NA 2960 5574 False False Inf 11.1567208042251 Inf 0 0 0.000177223493316982 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 18 0 13356 21313 0.00134589502018842 0.000797851614369596 0.00212626349435784 1 0.999826933785262 1 1 0.814698031862147 1 NA NA NA NA NA NA NA NA NA NA 2409 4479 False False 0 0 0 0 0 0 0 Inf 7.01399263973017 Inf 0 0 0.000276158286414525 1 0.999826933785262 1 5 3) Uncertain significance No change no 1 +Isoniazid katG p.Thr275Pro katG_p.Thr275Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Thr306Ala katG_p.Thr306Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Thr306Pro katG_p.Thr306Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2961 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Thr322Ala katG_p.Thr322Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.247471899512553 Inf 0.186160540855956 404 5574 False False Inf 0.247471899512553 Inf 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Thr322Lys katG_p.Thr322Lys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3269 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2642 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Thr322Pro katG_p.Thr322Pro 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Thr324Asn katG_p.Thr324Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Thr324Pro katG_p.Thr324Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Thr326Met katG_p.Thr326Met 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3465 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2798 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Thr326Pro katG_p.Thr326Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Thr344Leu katG_p.Thr344Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Thr344Met katG_p.Thr344Met 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3189 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2586 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Thr344Pro katG_p.Thr344Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 2 1 5 1 20841 27467 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.999963594000291 0.999797175631493 0.999999078280314 0.833333333333333 0.358765421002325 0.99578925548551 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 2.63586200278297 0.137203157383035 155.371863218055 0.58158365909274 1221 5574 False False 6.58965500695744 0.737267067818355 311.215258952954 9.59554766588303e-05 1.16208646408031e-05 0.00034658073323929 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 2 1 5 1 13369 21312 0.000373859727830118 0.000121402023062639 0.000872246401868143 0.999953080279641 0.999738608085756 0.999998812096234 0.833333333333333 0.358765421002325 0.99578925548551 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 3.18827137407435 0.16595332252126 187.894807730186 0.563279107739169 989 4479 False False 0 0 0 0 0 0 0 7.97067843518587 0.891722638077622 376.304140424995 0.000149577443721486 1.81150357058828e-05 0.000540219601407813 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Thr344Ser katG_p.Thr344Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3044 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2475 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Thr354Ile katG_p.Thr354Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 12 0 12 1 14 20845 27454 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999490316004077 0.999144984581285 0.999721323894632 0.0666666666666666 0.0016864302413527 0.319484566578303 0 0 0.264648469397051 0 0 0.231635761650116 0 0 0.474061053914681 0.00183810497055933 83 5574 False False 0.0940753178220196 0.00222904756778404 0.618441072579812 0 0 0.000176951454458875 0.999490316004077 0.999144984581285 0.999721323894632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 0 11 1 13 13373 21300 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.99939004363534 0.998957181904114 0.999675185224884 0.0714285714285714 0.00180678065912538 0.338684489931821 0 0 0.284914152918154 0 0 0.24705263800047 0 0 0.634759232426793 0.00913107328211662 89 4479 False False 0 0 0 0 0 0 0 0.122520118033465 0.00288692459724197 0.815921595502421 0 0 0.000275807277411719 0.99939004363534 0.998957181904114 0.999675185224884 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Thr363Ala katG_p.Thr363Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Thr376Lys katG_p.Thr376Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Thr376Met katG_p.Thr376Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Thr380_Gly494delinsSer katG_p.Thr380_Gly494delinsSer 1 inframe_deletion (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3190 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Isoniazid katG p.Thr380Ala katG_p.Thr380Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3171 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2571 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Thr380del katG_p.Thr380del 1 inframe_deletion (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3215 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2603 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Isoniazid katG p.Thr380Ile katG_p.Thr380Ile 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 1 0 27 1 20819 27467 0.00129521251079343 0.000853721301750774 0.00188391092655412 0.999963594000291 0.999797175631493 0.999999078280314 0.964285714285714 0.816522402455376 0.999096201244342 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.033826918371076 Inf 0.431171951042723 593 5574 False False 35.6217397569527 5.87007164099139 1448.49922424622 4.80307396733909e-05 1.21603230502644e-06 0.000267580774271935 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 25 0 13349 21313 0.00186929863915059 0.00121006548869323 0.00275822519578355 1 0.999826933785262 1 1 0.862814828469287 1 1 0.025 1 1 0.025 1 Inf 0.0409351498194313 Inf 0.385136889478694 472 4479 False False 0 0 0 0 0 0 0 Inf 10.0378046767938 Inf 7.49063670411985e-05 1.89646321926116e-06 0.000417280111858228 1 0.999826933785262 1 2 3) Uncertain significance No change no 1 +Isoniazid katG p.Thr380Pro katG_p.Thr380Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2962 5574 False False Inf 0.869878292971449 Inf 0 0 0.000176976922618654 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2410 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Thr380Ser katG_p.Thr380Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Thr394Ala katG_p.Thr394Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 3 0 4 1 20842 27467 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999963594000291 0.999797175631493 0.999999078280314 0.8 0.28358206388191 0.994949236620532 1 0.292401773821286 1 0.75 0.194120449683243 0.99369053679029 Inf 0.544532925267135 Inf 0.0803165622414995 284 5574 False False 5.27147106803569 0.521589398427432 259.279173455301 0.000143919405133125 2.96806247414452e-05 0.000420535394770913 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.299307766452077 Inf 0.148651468333857 217.5 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 NA 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Thr394fs katG_p.Thr394fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3344 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Thr435Ile katG_p.Thr435Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3528 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2837 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Thr468Pro katG_p.Thr468Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3417 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2766 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Thr475Ile katG_p.Thr475Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 16 1 15 3 17 20843 27451 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999381098004951 0.999009262277189 0.999639426758727 0.15 0.0320709371854637 0.378926826545313 0.0625 0.00158111172276588 0.302320738434531 0.0555555555555555 0.00140555616736942 0.272943599673368 0.0878024596587183 0.00208986700276067 0.570808581083751 0.00189564768888763 88 5574 False False 0.232418275567195 0.0436362565216145 0.803729427737468 4.79754365764728e-05 1.21463215353938e-06 0.000267272712750976 0.999381098004951 0.999009262277189 0.999639426758727 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 15 1 14 3 15 13371 21298 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999296204194623 0.998839461100611 0.999606039023746 0.166666666666666 0.0357850831215746 0.414177491394774 0.0666666666666666 0.0016864302413527 0.319484566578303 0.0625 0.00158111172276588 0.302320738434531 0.113775014156436 0.0026947352107306 0.748009965964534 0.0137398846241723 97 4479 False False 0 0 0 0 0 0 0 0.318570039638022 0.0591108516761482 1.12648849438386 7.47831289261142e-05 1.89334310623943e-06 0.000416593707936992 0.999296204194623 0.998839461100611 0.999606039023746 1 3) Uncertain significance No change no 1 +Isoniazid katG p.Thr520Ala katG_p.Thr520Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Thr520Asn katG_p.Thr520Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3236 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Thr568His katG_p.Thr568His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3484 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Thr568Pro katG_p.Thr568Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 7 0 20839 27468 0.000335795836131632 0.000135017659185429 0.000691744589626827 1 0.999865711673152 1 1 0.590383602774996 1 1 0.025 1 1 0.025 1 Inf 0.0337956847681309 Inf 0.431398526124037 604.5 5574 False False Inf 1.89951899263229 Inf 4.79846449136276e-05 1.21486528816812e-06 0.000267324007069132 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 4 0 13370 21313 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 1 0.999826933785262 1 1 0.397635364383525 1 1 0.025 1 1 0.025 1 Inf 0.0408708578619459 Inf 0.385509168492676 483 4479 False False 0 0 0 0 0 0 0 Inf 1.05210128917758 Inf 7.47887218607434e-05 1.89348470681633e-06 0.000416624859121756 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Thr579Ala katG_p.Thr579Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3139 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2544 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 1 3) Uncertain significance No change no 1 +Isoniazid katG p.Thr579Ser katG_p.Thr579Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3172 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2572 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Thr625Ala katG_p.Thr625Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 14 5 20832 27463 0.000671591672263264 0.000367212509754494 0.00112656023057506 0.999817970001456 0.999575254267103 0.999940892797913 0.736842105263157 0.487970654654127 0.908534215092333 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.43882149857577 0.0743956661692626 274 5574 False False 3.69126344086021 1.2560476153405 13.100250890993 0 0 0.000177061869457058 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 10 5 13364 21308 0.000747719455660236 0.000358616922835118 0.00137465137870696 0.999765401398207 0.999452610763328 0.999923822225278 0.666666666666666 0.383803732541154 0.881758896633119 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.74024733770179 0.163961622233158 270 4479 False False 0 0 0 0 0 0 0 3.18886560909907 0.992811490857679 11.8897798785733 0 0 0.000275992994481552 0.999765401398207 0.999452610763328 0.999923822225278 3 3) Uncertain significance No change no 1 +Isoniazid katG p.Thr625Lys katG_p.Thr625Lys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3466 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2799 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Thr625Pro katG_p.Thr625Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3503 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Thr647Pro katG_p.Thr647Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Thr654Ala katG_p.Thr654Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Thr654Asn katG_p.Thr654Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Thr654Ser katG_p.Thr654Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Thr667Pro katG_p.Thr667Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 5 1 20841 27467 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.999963594000291 0.999797175631493 0.999999078280314 0.833333333333333 0.358765421002325 0.99578925548551 0 0 0.975 0 0 0.975 0 0 51.360732841256 1 2027.5 5574 False False 6.58965500695744 0.737267067818355 311.215258952954 0 0 0.000176985413634466 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 1 13371 21312 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999953080279641 0.999738608085756 0.999998812096234 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 62.1055547471297 1 1642.5 4479 False False 0 0 0 0 0 0 0 4.78169172088849 0.383875689805931 250.696170545132 0 0 0.000275848526268708 0.999953080279641 0.999738608085756 0.999998812096234 5 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Thr677Pro katG_p.Thr677Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 8 0 20838 27468 0.000383766669864722 0.000165697303700768 0.000756032532322191 1 0.999865711673152 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 3485 5574 False False Inf 2.24970730189478 Inf 0 0 0.000177010891571197 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 5 0 13369 21313 0.000373859727830118 0.000121402023062639 0.000872246401868143 1 0.999826933785262 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 2809 4479 False False 0 0 0 0 0 0 0 Inf 1.46057233596553 Inf 0 0 0.000275889787465637 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Thr690Pro katG_p.Thr690Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 4 1 20842 27467 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999963594000291 0.999797175631493 0.999999078280314 0.8 0.28358206388191 0.994949236620532 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.31786776700892 0.0167951681556147 103.371981981508 1 1253.5 5574 False False 5.27147106803569 0.521589398427432 259.279173455301 4.79777383294151e-05 1.21469042880762e-06 0.000267285534484979 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.040864745349235 Inf 0.385544600126852 512 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 7.47775368279368e-05 1.89320152683959e-06 0.000416562561410248 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Thr77Arg katG_p.Thr77Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Thr85Ala katG_p.Thr85Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 1 20843 27467 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999963594000291 0.999797175631493 0.999999078280314 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 51.3558084523276 1 2027.5 5574 False False 3.95341361608213 0.31739219148065 207.323829234655 0 0 0.00017696843241753 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 1 13371 21312 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999953080279641 0.999738608085756 0.999998812096234 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 62.1055547471297 1 1642.5 4479 False False 0 0 0 0 0 0 0 4.78169172088849 0.383875689805931 250.696170545132 0 0 0.000275848526268708 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Thr85Pro katG_p.Thr85Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 51.349017027227 1 2027.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2535 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Thr9Lys katG_p.Thr9Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3296 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Trp107* katG_p.Trp107* 1 stop_gained (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Trp149Arg katG_p.Trp149Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.24749564543886 Inf 0.186140231321028 382.5 5574 False False Inf 0.869878292971449 Inf 9.59508731529456e-05 1.16203071146137e-05 0.000346564107961184 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.040864745349235 Inf 0.385544600126852 512 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 7.47775368279368e-05 1.89320152683959e-06 0.000416562561410248 1 0.999826933785262 1 2 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Trp149Cys katG_p.Trp149Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3297 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2668 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Trp149Gly katG_p.Trp149Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 8 0 20838 27468 0.000383766669864722 0.000165697303700768 0.000756032532322191 1 0.999865711673152 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 3446 5574 False False Inf 2.24970730189478 Inf 0 0 0.000177010891571197 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 8 0 13366 21313 0.000598175564528189 0.000258283997825234 0.00117830226263269 1 0.999826933785262 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 2783 4479 False False 0 0 0 0 0 0 0 Inf 2.72130996382454 Inf 0 0 0.000275951702410535 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Trp149* katG_p.Trp149* 1 stop_gained (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3140 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2545 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Trp161Arg katG_p.Trp161Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 5 0 5 2 20841 27466 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.999927188000582 0.999737003036386 0.999991182007438 0.714285714285714 0.290420863737342 0.963307433823914 1 0.478176249895018 1 0.714285714285714 0.290420863737342 0.963307433823914 Inf 1.20752192743194 Inf 0.0149527175916041 146 5574 False False 3.29470754762247 0.539313466840718 34.60579842565 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 5 0 5 0 13369 21313 0.000373859727830118 0.000121402023062639 0.000872246401868143 1 0.999826933785262 1 1 0.478176249895018 1 1 0.478176249895018 1 1 0.478176249895018 1 Inf 1.46057233596553 Inf 0.00851673893767771 70 4479 False False 0 0 0 0 0 0 0 Inf 1.46057233596553 Inf 0.000373859727830118 0.000121402023062639 0.000872246401868143 1 0.999826933785262 1 NA 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Trp161Gln katG_p.Trp161Gln 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3448 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2784 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Trp161* katG_p.Trp161* 1 stop_gained (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3447 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Trp191Arg katG_p.Trp191Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 27 3 20819 27465 0.00129521251079343 0.000853721301750774 0.00188391092655412 0.999890782000873 0.99968085216583 0.999977476056514 0.9 0.734711549525791 0.978882862970277 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.19278883456594 0.264205216678763 576 5574 False False 11.8730486574763 3.65239226520502 61.1837847587639 0 0 0.000177172422335812 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 9 3 13365 21310 0.000672947510094212 0.000307759154923187 0.00127707788784856 0.999859240838924 0.999588697652472 0.999970971136275 0.75 0.42814153812181 0.945139355472007 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85911586484202 0.289377028964572 415 4479 False False 0 0 0 0 0 0 0 4.78338945005611 1.19341740935517 27.4726907243458 0 0 0.000275972346901473 0.999859240838924 0.999588697652472 0.999970971136275 4 3) Uncertain significance No change no 1 +Isoniazid katG p.Trp191Gly katG_p.Trp191Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 1 5 18 7 20828 27461 0.000863475007195625 0.000511827761943967 0.00136432078973001 0.999745158002038 0.999474999027776 0.999897534357495 0.72 0.506123178193744 0.879283311495933 0.166666666666666 0.00421074451448947 0.641234578997674 0.125 0.0031597235312519 0.526509670875206 0.263693105434991 0.00557936907317445 2.35684634788997 0.245112675935821 419 5574 False False 3.39033992702131 1.35081418594235 9.60250016337595 4.8009986077104e-05 1.21550687009947e-06 0.00026746516801679 0.999745158002038 0.999474999027776 0.999897534357495 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 1 3 14 5 13360 21308 0.00104680723792433 0.000572413688832994 0.00175574154681136 0.999765401398207 0.999452610763328 0.999923822225278 0.736842105263157 0.487970654654127 0.908534215092333 0.25 0.00630946320970987 0.805879550316756 0.166666666666666 0.00421074451448947 0.641234578997674 0.531636726546906 0.010130911113154 6.6221277316804 1 1642.5 4479 False False 0 0 0 0 0 0 0 4.46574850299401 1.51941633463818 15.8458254111965 7.48446972531996e-05 1.89490187836998e-06 0.000416936627390637 0.999765401398207 0.999452610763328 0.999923822225278 1 3) Uncertain significance No change no 1 +Isoniazid katG p.Trp198fs katG_p.Trp198fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3237 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Trp198* katG_p.Trp198* 1 stop_gained (see "Genomic_coordinates" sheet) 2 1 1 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0337875782094303 Inf 0.431457371721896 645 5574 False False Inf 0.247471899512553 Inf 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2838 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Trp204* katG_p.Trp204* 1 stop_gained (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Trp300Arg katG_p.Trp300Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.24748377190611 Inf 0.186150386160192 389.5 5574 False False Inf 0.544526627735454 Inf 9.59462700887503e-05 1.16197496419179e-05 0.000346547484278011 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.299307766452077 Inf 0.148651468333857 217.5 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 NA 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Trp300Cys katG_p.Trp300Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0337863481185338 Inf 0.431466302367941 667 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0408597725378736 Inf 0.385573430202387 666 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Trp300Gly katG_p.Trp300Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 3 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.544552746865154 Inf 0.0803115749774769 281 5574 False False Inf 0.869878292971449 Inf 0.000143919405133125 2.96806247414452e-05 0.000420535394770913 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.299330161198724 Inf 0.148637808646281 204 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0.000149555073655873 1.81123264336181e-05 0.000540138824607934 1 0.999826933785262 1 1 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Trp300Ser katG_p.Trp300Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Trp300* katG_p.Trp300* 1 stop_gained (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3016 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Trp321Ser katG_p.Trp321Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3076 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2499 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Trp321* katG_p.Trp321* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0337875782094303 Inf 0.431457371721896 645 5574 False False Inf 0.247471899512553 Inf 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Trp328Arg katG_p.Trp328Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0337875782094303 Inf 0.431457371721896 645 5574 False False Inf 0.247471899512553 Inf 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.040864745349235 Inf 0.385544600126852 512 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 7.47775368279368e-05 1.89320152683959e-06 0.000416562561410248 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Trp328Cys katG_p.Trp328Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0337875782094303 Inf 0.431457371721896 645 5574 False False Inf 0.247471899512553 Inf 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.040864745349235 Inf 0.385544600126852 512 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 7.47775368279368e-05 1.89320152683959e-06 0.000416562561410248 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Trp328Leu katG_p.Trp328Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 12 12 0 12 0 20834 27468 0.000575650004797083 0.000297481006307132 0.00100532857413147 1 0.999865711673152 1 1 0.735351530602948 1 1 0.735351530602948 1 1 0.735351530602948 1 Inf 3.66300284077067 Inf 4.15541995199012e-05 55 5574 True False Inf 3.66300284077067 Inf 0.000575650004797083 0.000297481006307132 0.00100532857413147 1 0.999865711673152 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 9 9 0 9 0 13365 21313 0.000672947510094212 0.000307759154923187 0.00127707788784856 1 0.999826933785262 1 1 0.663732883120057 1 1 0.663732883120057 1 1 0.663732883120057 1 Inf 3.14671336895126 Inf 0.000187989113615184 39 4479 True False 0 0 0 0 0 0 0 Inf 3.14671336895126 Inf 0.000672947510094212 0.000307759154923187 0.00127707788784856 1 0.999826933785262 1 NA Assoc w R 1) Assoc w R High-level resistance No change yes G 1 +Isoniazid katG p.Trp328Ser katG_p.Trp328Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3106 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2522 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 1 3) Uncertain significance No change no 1 +Isoniazid katG p.Trp328Tyr katG_p.Trp328Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Trp341Gly katG_p.Trp341Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3418 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Trp351fs katG_p.Trp351fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3298 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2669 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Trp351Leu katG_p.Trp351Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Trp351* katG_p.Trp351* 1 stop_gained (see "Genomic_coordinates" sheet) 2 1 1 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0337875782094303 Inf 0.431457371721896 645 5574 False False Inf 0.247471899512553 Inf 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Trp397Gly katG_p.Trp397Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Trp397* katG_p.Trp397* 1 stop_gained (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3045 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2476 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Trp39Arg katG_p.Trp39Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3092 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Trp39fs katG_p.Trp39fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Trp39* katG_p.Trp39* 1 stop_gained (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Trp412Cys katG_p.Trp412Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Trp412* katG_p.Trp412* 1 stop_gained (see "Genomic_coordinates" sheet) 1 2 2 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.24749564543886 Inf 0.186140231321028 382.5 5574 False False Inf 0.869878292971449 Inf 9.59508731529456e-05 1.16203071146137e-05 0.000346564107961184 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.299330161198724 Inf 0.148637808646281 204 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0.000149555073655873 1.81123264336181e-05 0.000540138824607934 1 0.999826933785262 1 NA Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change AwRI by relaxed thresholds (not endorsed) no G, O 1 +Isoniazid katG p.Trp412Tyr katG_p.Trp412Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3356 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2714 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Trp438Cys katG_p.Trp438Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3467 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2800 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Trp438Gly katG_p.Trp438Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 1 0.025 1 1 0.025 1 Inf 0.0337891992100405 Inf 0.431445603576751 617.5 5574 False False Inf 0.544526627735454 Inf 4.79754365764728e-05 1.21463215353938e-06 0.000267272712750976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.040864745349235 Inf 0.385544600126852 512 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 7.47775368279368e-05 1.89320152683959e-06 0.000416562561410248 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Trp438* katG_p.Trp438* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 1 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 1 0.025 1 1 0.025 1 Inf 0.0337891992100405 Inf 0.431445603576751 617.5 5574 False False Inf 0.544526627735454 Inf 4.79754365764728e-05 1.21463215353938e-06 0.000267272712750976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 1 0.025 1 1 0.025 1 Inf 0.0408678013770354 Inf 0.385526884820527 489.5 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 7.47831289261142e-05 1.89334310623943e-06 0.000416593707936992 1 0.999826933785262 1 NA Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Trp477* katG_p.Trp477* 1 stop_gained (see "Genomic_coordinates" sheet) 1 3 2 1 3 1 20843 27467 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999963594000291 0.999797175631493 0.999999078280314 0.75 0.194120449683243 0.99369053679029 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 2.63560907738809 0.13718999164004 155.35696976537 0.581595476863033 1223 5574 False False 3.95341361608213 0.31739219148065 207.323829234655 9.59462700887503e-05 1.16197496419179e-05 0.000346547484278011 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change AwRI by relaxed thresholds (not endorsed) no G, O 1 +Isoniazid katG p.Trp505Arg katG_p.Trp505Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3077 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2500 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Trp505fs katG_p.Trp505fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3373 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2727 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Trp505Ser katG_p.Trp505Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3387 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2739 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Trp505* katG_p.Trp505* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0337875782094303 Inf 0.431457371721896 645 5574 False False Inf 0.247471899512553 Inf 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.040864745349235 Inf 0.385544600126852 512 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 7.47775368279368e-05 1.89320152683959e-06 0.000416562561410248 1 0.999826933785262 1 NA Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Trp668Cys katG_p.Trp668Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3173 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Trp668fs katG_p.Trp668fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3000 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2443 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Trp668* katG_p.Trp668* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0337875782094303 Inf 0.431457371721896 645 5574 False False Inf 0.247471899512553 Inf 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Trp689Cys katG_p.Trp689Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3174 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2573 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Trp689fs katG_p.Trp689fs 1 frameshift (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Trp689Gly katG_p.Trp689Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.31767810026385 0.0167927522337569 103.35711725526 1 1253.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Trp689* katG_p.Trp689* 1 stop_gained (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Trp728Cys katG_p.Trp728Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Trp728Phe katG_p.Trp728Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3270 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2643 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Trp728* katG_p.Trp728* 1 stop_gained (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3419 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2767 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Trp728Tyr katG_p.Trp728Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Trp90Arg katG_p.Trp90Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3078 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Isoniazid katG p.Trp90Cys katG_p.Trp90Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3191 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2587 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Trp90* katG_p.Trp90* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Trp91Arg katG_p.Trp91Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 3 20844 27465 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999890782000873 0.99968085216583 0.999977476056514 0.4 0.0527449505263169 0.853367200365326 1 0.025 1 0.25 0.00630946320970987 0.805879550316756 Inf 0.0337838879367385 Inf 0.431484164769199 827.5 5574 False False 0.878430243715217 0.0733354884838472 7.66963698207431 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 3 0 3 1 3 13373 21310 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999859240838924 0.999588697652472 0.999970971136275 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85680682534852 0.289279625558287 389.5 4479 False False 0 0 0 0 0 0 0 0.531169769934445 0.010122018243966 6.61631049307563 0 0 0.000275807277411719 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Trp91Gly katG_p.Trp91Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Tyr113* katG_p.Tyr113* 1 stop_gained (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Tyr155Asp katG_p.Tyr155Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0337875782094303 Inf 0.431457371721896 645 5574 False False Inf 0.247471899512553 Inf 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.040864745349235 Inf 0.385544600126852 512 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 7.47775368279368e-05 1.89320152683959e-06 0.000416562561410248 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Tyr155Cys katG_p.Tyr155Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 10 1 20836 27467 0.000479708337330902 0.000230061997553563 0.000882023176671562 0.999963594000291 0.999797175631493 0.999999078280314 0.909090909090909 0.587220083011617 0.997701027786185 0 0 0.975 0 0 0.975 0 0 51.3730479462142 1 2027.5 5574 False False 13.1824726435016 1.87489573468025 570.603433894195 0 0 0.000177027880937939 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 1 13371 21312 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999953080279641 0.999738608085756 0.999998812096234 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 62.1055547471297 1 1642.5 4479 False False 0 0 0 0 0 0 0 4.78169172088849 0.383875689805931 250.696170545132 0 0 0.000275848526268708 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Tyr155Ser katG_p.Tyr155Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 8 0 20838 27468 0.000383766669864722 0.000165697303700768 0.000756032532322191 1 0.999865711673152 1 1 0.63058335244718 1 1 0.025 1 1 0.025 1 Inf 0.0337973065466778 Inf 0.431386755542675 602.5 5574 False False Inf 2.24970730189478 Inf 4.79869475502663e-05 1.21492358580957e-06 0.000267336833725155 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 5 0 13369 21313 0.000373859727830118 0.000121402023062639 0.000872246401868143 1 0.999826933785262 1 1 0.478176249895018 1 1 0.025 1 1 0.025 1 Inf 0.0408739148040691 Inf 0.385491451143211 481 4479 False False 0 0 0 0 0 0 0 Inf 1.46057233596553 Inf 7.47943156320119e-05 1.89362632857505e-06 0.000416656014965588 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Tyr155* katG_p.Tyr155* 1 stop_gained (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Tyr197Asp katG_p.Tyr197Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3345 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2705 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Tyr197fs katG_p.Tyr197fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Tyr229Cys katG_p.Tyr229Cys 1 missense_variant (see "Genomic_coordinates" sheet) 2 2 2 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.247471899512553 Inf 0.186160540855956 404 5574 False False Inf 0.247471899512553 Inf 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 2 2 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.299307766452077 Inf 0.148651468333857 217.5 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain AwRI by relaxed thresholds (not endorsed) yes O 0 +Isoniazid katG p.Tyr28* katG_p.Tyr28* 1 stop_gained (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3299 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2670 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Tyr337Asp katG_p.Tyr337Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Tyr337Cys katG_p.Tyr337Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 9 1 20837 27467 0.000431737503597812 0.000197436276106449 0.000819413341228355 0.999963594000291 0.999797175631493 0.999999078280314 0.9 0.554983882971804 0.997471421455538 1 0.158113883008419 1 0.666666666666666 0.0942993240502461 0.991596241340387 Inf 0.247546017523595 Inf 0.186097159744399 377 5574 False False 11.8636559965446 1.6436266007203 518.765276537541 9.59738951005326e-05 1.162309528065e-05 0.000346647250305642 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 4 1 13370 21312 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 0.999953080279641 0.999738608085756 0.999998812096234 0.8 0.28358206388191 0.994949236620532 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0408689401912183 Inf 0.385520283712481 485 4479 False False 0 0 0 0 0 0 0 6.37606581899775 0.630846560224411 313.513380938872 7.47887218607434e-05 1.89348470681633e-06 0.000416624859121756 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Tyr339fs katG_p.Tyr339fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Tyr353_Thr354insAsn katG_p.Tyr353_Thr354insAsn 1 inframe_insertion (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3449 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Isoniazid katG p.Tyr353Cys katG_p.Tyr353Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Tyr390Cys katG_p.Tyr390Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Tyr390dup katG_p.Tyr390dup 1 inframe_insertion (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3315 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Isoniazid katG p.Tyr390Ser katG_p.Tyr390Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0337875782094303 Inf 0.431457371721896 645 5574 False False Inf 0.247471899512553 Inf 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.040864745349235 Inf 0.385544600126852 512 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 7.47775368279368e-05 1.89320152683959e-06 0.000416562561410248 1 0.999826933785262 1 3 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Tyr413Cys katG_p.Tyr413Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 5 2 20841 27466 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.999927188000582 0.999737003036386 0.999991182007438 0.714285714285714 0.290420863737342 0.963307433823914 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01767196366986 0.509398939450249 1198.5 5574 False False 3.29470754762247 0.539313466840718 34.60579842565 0 0 0.000176985413634466 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48598624162872 0.526186417038858 925 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Tyr413His katG_p.Tyr413His 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 1 3 2 3 20844 27465 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999890782000873 0.99968085216583 0.999977476056514 0.4 0.0527449505263169 0.853367200365326 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.439215121857608 0.00837089758444131 5.47074630621783 0.638947469249971 1231 5574 False False 0.878430243715217 0.0733354884838472 7.66963698207431 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Tyr413* katG_p.Tyr413* 1 stop_gained (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3486 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2810 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Tyr426His katG_p.Tyr426His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3151 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2555 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Tyr597His katG_p.Tyr597His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 5 0 20841 27468 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 1 0.999865711673152 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 3107 5574 False False Inf 1.20760984683633 Inf 0 0 0.000176985413634466 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 5 0 13369 21313 0.000373859727830118 0.000121402023062639 0.000872246401868143 1 0.999826933785262 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 2523 4479 False False 0 0 0 0 0 0 0 Inf 1.46057233596553 Inf 0 0 0.000275889787465637 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Tyr597Ser katG_p.Tyr597Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3175 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2574 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Tyr638Cys katG_p.Tyr638Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Tyr64Asn katG_p.Tyr64Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3017 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2453 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Tyr64Asp katG_p.Tyr64Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3374 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2728 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Tyr64Cys katG_p.Tyr64Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3284 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Tyr64His katG_p.Tyr64His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3001 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Tyr64Ser katG_p.Tyr64Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3192 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2588 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Tyr678Ala katG_p.Tyr678Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Tyr678Cys katG_p.Tyr678Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3388 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Tyr678Leu katG_p.Tyr678Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3216 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2604 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Tyr95fs katG_p.Tyr95fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3018 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Tyr98Cys katG_p.Tyr98Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.24749564543886 Inf 0.186140231321028 382.5 5574 False False Inf 0.869878292971449 Inf 9.59508731529456e-05 1.16203071146137e-05 0.000346564107961184 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.040864745349235 Inf 0.385544600126852 512 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 7.47775368279368e-05 1.89320152683959e-06 0.000416562561410248 1 0.999826933785262 1 NA 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Val151_Tyr155delinsAsp katG_p.Val151_Tyr155delinsAsp 1 inframe_deletion (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Isoniazid katG p.Val166fs katG_p.Val166fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Val166Ile katG_p.Val166Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Val196Ala katG_p.Val196Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3255 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Val196Gly katG_p.Val196Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3357 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2715 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Val196Ile katG_p.Val196Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Val22fs katG_p.Val22fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3331 5574 False False Inf 0.869878292971449 Inf 0 0 0.000176976922618654 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Val23_Val30del katG_p.Val23_Val30del 1 inframe_deletion (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3468 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Isoniazid katG p.Val230Ala katG_p.Val230Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3019 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2454 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Val23Leu katG_p.Val23Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 1.99604811372315 0.139118032244638 322.5 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.41420404242617 0.305473156458586 444 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Val246Gly katG_p.Val246Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3316 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2682 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Val260Ile katG_p.Val260Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Val260Leu katG_p.Val260Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3271 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2644 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Val267Ala katG_p.Val267Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Val267Gly katG_p.Val267Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Val284Ile katG_p.Val284Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3389 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2740 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Val30fs katG_p.Val30fs 1 frameshift (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Val319Asp katG_p.Val319Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Val319fs katG_p.Val319fs 1 frameshift (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Val319Ile katG_p.Val319Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Val320Ala katG_p.Val320Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3346 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2706 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Val320Leu katG_p.Val320Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3238 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2622 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Val386fs katG_p.Val386fs 1 frameshift (see "Genomic_coordinates" sheet) 2 1 1 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0337875782094303 Inf 0.431457371721896 645 5574 False False Inf 0.247471899512553 Inf 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.040864745349235 Inf 0.385544600126852 512 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 7.47775368279368e-05 1.89320152683959e-06 0.000416562561410248 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Val386Glu katG_p.Val386Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 5 0 20841 27468 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 1 0.999865711673152 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 3375 5574 False False Inf 1.20760984683633 Inf 0 0 0.000176985413634466 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2729 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 1 3) Uncertain significance No change no 1 +Isoniazid katG p.Val386Leu katG_p.Val386Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3300 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2671 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Val386Met katG_p.Val386Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Val423Ile katG_p.Val423Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 2 7 8 7 20838 27461 0.000383766669864722 0.000165697303700768 0.000756032532322191 0.999745158002038 0.999474999027776 0.999897534357495 0.533333333333333 0.265861347277396 0.787333270480692 0.222222222222222 0.0281449734778982 0.600093573716312 0.222222222222222 0.0281449734778982 0.600093573716312 0.376523658700451 0.0381619742276785 1.9778685104573 0.315884230542574 579 5574 False False 1.5060946348018 0.477150375804276 4.87970314895109 9.59692898272552e-05 1.16225375404095e-05 0.000346630618645506 0.999745158002038 0.999474999027776 0.999897534357495 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 4 1 13370 21312 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 0.999953080279641 0.999738608085756 0.999998812096234 0.8 0.28358206388191 0.994949236620532 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.59401645474943 0.020305112584781 125.011828468438 1 1642.5 4479 False False 0 0 0 0 0 0 0 6.37606581899775 0.630846560224411 313.513380938872 7.47887218607434e-05 1.89348470681633e-06 0.000416624859121756 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change AwRI by relaxed thresholds (not endorsed) yes O 1 +Isoniazid katG p.Val423Phe katG_p.Val423Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Val431fs katG_p.Val431fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.247471899512553 Inf 0.186160540855956 404 5574 False False Inf 0.247471899512553 Inf 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.299307766452077 Inf 0.148651468333857 217.5 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change AwRI by relaxed thresholds (not endorsed) no G, O 1 +Isoniazid katG p.Val431Gly katG_p.Val431Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Val442Ala katG_p.Val442Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3450 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2785 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Val445fs katG_p.Val445fs 1 frameshift (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Val445Ile katG_p.Val445Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Val450Ala katG_p.Val450Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3061 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Val469Leu katG_p.Val469Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 0 56 20846 27412 0 0 0.00017694296670111 0.99796126401631 0.997353337776529 0.99845960453209 0 0 0.0637500966623622 NA NA NA 0 0 0.0637500966623622 NA NA NA NA NA NA False True 0 0 0.0895529163620331 0 0 0.00017694296670111 0.99796126401631 0.997353337776529 0.99845960453209 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 0 46 13374 21267 0 0 0.000275786657608973 0.99784169286351 0.9971221582447 0.998419427888433 0 0 0.0770618270519006 NA NA NA 0 0 0.0770618270519006 NA NA NA NA NA NA False True 1 1 1 0 0 1 0 0 0 0.132803893902898 0 0 0.000275786657608973 0.99784169286351 0.9971221582447 0.998419427888433 7 Not assoc w R 5) Not assoc w R No change yes 1 +Isoniazid katG p.Val473Ala katG_p.Val473Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Val473Leu katG_p.Val473Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 14 2 20832 27466 0.000671591672263264 0.000367212509754494 0.00112656023057506 0.999927188000582 0.999737003036386 0.999991182007438 0.875 0.616523763150736 0.984486396184586 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.65922619047619 0.0111788232184046 12.6646379427197 1 1253.5 5574 False False 9.22916666666666 2.11925971289138 83.8292336247292 4.80007680122881e-05 1.21527348918813e-06 0.000267413819517412 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 13 2 13361 21311 0.000972035292358307 0.000517666151348512 0.00166163634851859 0.999906160559283 0.999661061221376 0.999988635406343 0.866666666666666 0.595397303396627 0.983424086559916 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.49360801347896 0.526283861836767 982 4479 False False 0 0 0 0 0 0 0 10.367599730559 2.34662296676086 94.6582484799212 0 0 0.000276054955763573 0.999906160559283 0.999661061221376 0.999988635406343 6 3) Uncertain significance No change no 1 +Isoniazid katG p.Val473Phe katG_p.Val473Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Val47Ile katG_p.Val47Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 20846 27462 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.11900921779861 0.0402109359097128 194.5 5574 False False 0 0 1.11900921779861 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 13374 21307 0 0 0.000275786657608973 0.999718481677849 0.999387354605726 0.999896680954833 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.35335561005417 0.0884814409570568 164 4479 False False 0 0 0 0 0 0 0 0 0 1.35335561005417 0 0 0.000275786657608973 0.999718481677849 0.999387354605726 0.999896680954833 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Val503Ala katG_p.Val503Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance No change no 1 +Isoniazid katG p.Val507Ile katG_p.Val507Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Val517fs katG_p.Val517fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3420 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2768 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Val538Ala katG_p.Val538Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Val538fs katG_p.Val538fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3176 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2575 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Val538Leu katG_p.Val538Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Val565Gly katG_p.Val565Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3390 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2741 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Val581Met katG_p.Val581Met 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3141 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2546 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Val586fs katG_p.Val586fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Val586Met katG_p.Val586Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.658815063564403 0.011171855707321 12.6567401482543 1 2027.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.59365886487699 0.0203005577541163 124.983813232444 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Val626Ala katG_p.Val626Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3317 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Val626Glu katG_p.Val626Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3193 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Val628Gly katG_p.Val628Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3020 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2455 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Val628Leu katG_p.Val628Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Val633Ile katG_p.Val633Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Val68Gly katG_p.Val68Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 1 20843 27467 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999963594000291 0.999797175631493 0.999999078280314 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 51.3558084523276 1 2027.5 5574 False False 3.95341361608213 0.31739219148065 207.323829234655 0 0 0.00017696843241753 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 62.1009148060541 1 1642.5 4479 False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 0 0 0.000275827900298067 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Val697Ala katG_p.Val697Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3002 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Val697Leu katG_p.Val697Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 5 0 20841 27468 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 1 0.999865711673152 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 3194 5574 False False Inf 1.20760984683633 Inf 0 0 0.000176985413634466 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Val710Gly katG_p.Val710Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0337875782094303 Inf 0.431457371721896 645 5574 False False Inf 0.247471899512553 Inf 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.040864745349235 Inf 0.385544600126852 512 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 7.47775368279368e-05 1.89320152683959e-06 0.000416562561410248 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Val710Ile katG_p.Val710Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Val721Leu katG_p.Val721Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Val731Gly katG_p.Val731Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3093 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2512 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Val731Met katG_p.Val731Met 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3469 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Val739Met katG_p.Val739Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3108 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2524 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Val73Ala katG_p.Val73Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Val73Gly katG_p.Val73Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3285 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2655 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid katG p.Val83fs katG_p.Val83fs 1 frameshift (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim High-level resistance No change no G 1 +Isoniazid katG p.Val83Gly katG_p.Val83Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3529 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2839 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 3 3) Uncertain significance New Uncertain no 0 +Isoniazid katG p.Val83Leu katG_p.Val83Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3318 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2683 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.1026G>A mshA_c.1026G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.102C>T mshA_c.102C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.1035G>A mshA_c.1035G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.1041G>T mshA_c.1041G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.1044G>A mshA_c.1044G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.1053C>T mshA_c.1053C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 28 0 20818 27468 0.00134318334452652 0.000892715366584833 0.00194069331308385 1 0.999865711673152 1 1 0.876563881499736 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 9.36739739964436 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 25 0 13349 21313 0.00186929863915059 0.00121006548869323 0.00275822519578355 1 0.999826933785262 1 1 0.862814828469287 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 10.0378046767938 Inf NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.1056C>T mshA_c.1056C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.105T>C mshA_c.105T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.1080G>T mshA_c.1080G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.1086C>T mshA_c.1086C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-108G>A mshA_c.-108G>A 2 upstream_gene_variant 575240 1 7 0 7 4 10 20842 27458 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999635940002912 0.999330582956894 0.999825405716755 0.285714285714285 0.0838893183071275 0.581035257183661 0 0 0.409616397225003 0 0 0.30849710781876 0 0 0.914196784333724 0.021978801546974 163 5574 False False 0.526974378658478 0.12062211620331 1.82733051585021 0 0 0.000176976922618654 0.999635940002912 0.999330582956894 0.999825405716755 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 4 8 13370 21305 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 0.999624642237132 0.999260530264256 0.999837933676441 0.333333333333333 0.0992460911495833 0.651124493581186 0 0 0.4592581264399 0 0 0.369416647552819 0 0 1.35363337409752 0.088487189005544 185 4479 False False 0 0 0 0 0 0 0 0.796746447270007 0.175554888158817 2.97493777258165 0 0 0.000275869155324334 0.999624642237132 0.999260530264256 0.999837933676441 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.1092G>A mshA_c.1092G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 1 20843 27467 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999963594000291 0.999797175631493 0.999999078280314 0.75 0.194120449683243 0.99369053679029 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.95341361608213 0.31739219148065 207.323829234655 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.1098C>T mshA_c.1098C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.18865318395302 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.85651838973546 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.1116G>A mshA_c.1116G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.1116G>T mshA_c.1116G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-111C>T mshA_c.-111C>T 2 upstream_gene_variant 575237 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4063 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.1125C>A mshA_c.1125C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.1125C>T mshA_c.1125C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.1131G>A mshA_c.1131G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.1137C>T mshA_c.1137C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.18865318395302 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.85651838973546 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.1146C>T mshA_c.1146C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-114T>C mshA_c.-114T>C 2 upstream_gene_variant 575234 1 3 1 2 2 2 20844 27466 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999927188000582 0.999737003036386 0.999991182007438 0.5 0.067585986488543 0.932414013511457 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.658846670504701 0.0111723913611586 12.657347321213 1 2027.5 5574 False False 1.3176933410094 0.0955278435529395 18.1762534351792 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.59365886487699 0.0203005577541163 124.983813232444 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.1152G>C mshA_c.1152G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.1161C>A mshA_c.1161C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 11 1 20835 27467 0.000527679171063993 0.000263444034397523 0.000943967185544106 0.999963594000291 0.999797175631493 0.999999078280314 0.916666666666666 0.615203834849055 0.997892406768139 NA NA NA NA NA NA NA NA NA NA NA NA False False 14.501415886729 2.10741512283775 622.42135891494 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 4 1 13370 21312 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 0.999953080279641 0.999738608085756 0.999998812096234 0.8 0.28358206388191 0.994949236620532 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 6.37606581899775 0.630846560224411 313.513380938872 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.1164C>T mshA_c.1164C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.1165C>T mshA_c.1165C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.1173C>T mshA_c.1173C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.1179C>T mshA_c.1179C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 1 20843 27467 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999963594000291 0.999797175631493 0.999999078280314 0.75 0.194120449683243 0.99369053679029 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.95341361608213 0.31739219148065 207.323829234655 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 1 13371 21312 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999953080279641 0.999738608085756 0.999998812096234 0.75 0.194120449683243 0.99369053679029 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.78169172088849 0.383875689805931 250.696170545132 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.117G>T mshA_c.117G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 20846 27462 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.11900921779861 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 5 13374 21308 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.73894646374006 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.1182G>A mshA_c.1182G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.1197C>T mshA_c.1197C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.1203C>G mshA_c.1203C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-120A>T mshA_c.-120A>T 2 upstream_gene_variant 575228 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3904 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3134 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.1212C>T mshA_c.1212C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.1215G>A mshA_c.1215G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.1216C>T mshA_c.1216C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.247471899512553 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-121C>T mshA_c.-121C>T 2 upstream_gene_variant 575227 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3968 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3181 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.1227T>C mshA_c.1227T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 21 20844 27447 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999235474006116 0.998831576963824 0.999526686034611 0.0869565217391304 0.0107099660378758 0.280379335909411 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.1254077912109 0.0142262099872465 0.513147432883023 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 15 13372 21298 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999296204194623 0.998839461100611 0.999606039023746 0.117647058823529 0.0145793168403025 0.36440916210125 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.21236414398245 0.0235340015460264 0.913434910477646 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.1236A>C mshA_c.1236A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 11 1 20835 27467 0.000527679171063993 0.000263444034397523 0.000943967185544106 0.999963594000291 0.999797175631493 0.999999078280314 0.916666666666666 0.615203834849055 0.997892406768139 NA NA NA NA NA NA NA NA NA NA NA NA False False 14.501415886729 2.10741512283775 622.42135891494 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 10 1 13364 21312 0.000747719455660236 0.000358616922835118 0.00137465137870696 0.999953080279641 0.999738608085756 0.999998812096234 0.909090909090909 0.587220083011617 0.997701027786185 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 15.9473211613289 2.26794807805506 689.853896155571 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.1239G>A mshA_c.1239G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.1245G>A mshA_c.1245G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 8 0 20838 27468 0.000383766669864722 0.000165697303700768 0.000756032532322191 1 0.999865711673152 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 2.24970730189478 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 8 0 13366 21313 0.000598175564528189 0.000258283997825234 0.00117830226263269 1 0.999826933785262 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 2.72130996382454 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-125G>A mshA_c.-125G>A 2 upstream_gene_variant 575223 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4036 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.1260G>T mshA_c.1260G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.1263G>A mshA_c.1263G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.1278C>T mshA_c.1278C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.129C>T mshA_c.129C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.1302C>T mshA_c.1302C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.1309C>T mshA_c.1309C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.1317C>T mshA_c.1317C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.1329T>C mshA_c.1329T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-132C>A mshA_c.-132C>A 2 upstream_gene_variant 575216 1 0 0 0 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4071 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3262 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 4 3) Uncertain significance No change no 1 +Isoniazid mshA c.132G>A mshA_c.132G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 2 20843 27466 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999927188000582 0.999737003036386 0.999991182007438 0.6 0.146632799634673 0.947255049473683 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.97663484143357 0.226402568392661 23.6672561646805 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 1 13371 21312 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999953080279641 0.999738608085756 0.999998812096234 0.75 0.194120449683243 0.99369053679029 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.78169172088849 0.383875689805931 250.696170545132 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.1332G>T mshA_c.1332G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.1338C>T mshA_c.1338C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.1347C>T mshA_c.1347C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.1365G>A mshA_c.1365G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.1365G>C mshA_c.1365G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 2 20844 27466 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999927188000582 0.999737003036386 0.999991182007438 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.3176933410094 0.0955278435529395 18.1762534351792 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.1365G>T mshA_c.1365G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.1368C>A mshA_c.1368C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.1368C>T mshA_c.1368C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-136G>C mshA_c.-136G>C 2 upstream_gene_variant 575212 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3905 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.1371C>A mshA_c.1371C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.1383G>A mshA_c.1383G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.247471899512553 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.1398G>T mshA_c.1398G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.1410C>G mshA_c.1410C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.99604811372315 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.41420404242617 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.1419G>A mshA_c.1419G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 20846 27462 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.11900921779861 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.1425T>C mshA_c.1425T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-146T>G mshA_c.-146T>G 2 upstream_gene_variant 575202 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3241 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.150G>A mshA_c.150G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-152A>G mshA_c.-152A>G 2 upstream_gene_variant 575196 NA 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3922 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3149 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-153C>T mshA_c.-153C>T 2 upstream_gene_variant 575195 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-155G>C mshA_c.-155G>C 2 upstream_gene_variant 575193 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-156A>G mshA_c.-156A>G 2 upstream_gene_variant 575192 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.156G>A mshA_c.156G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-163C>T mshA_c.-163C>T 2 upstream_gene_variant 575185 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.169C>T mshA_c.169C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-16T>G mshA_c.-16T>G 2 upstream_gene_variant 575332 1 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3964 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3176 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.171G>A mshA_c.171G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-172_-171insG mshA_c.-172_-171insG 2 upstream_gene_variant 575176 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3943 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.-172T>C mshA_c.-172T>C 2 upstream_gene_variant 575176 NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3883 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3117 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.174A>G mshA_c.174A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.63548263289195 0.137183409715989 155.34952410964 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-175G>A mshA_c.-175G>A 2 upstream_gene_variant 575173 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-180C>T mshA_c.-180C>T 2 upstream_gene_variant 575168 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4028 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3227 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.-181G>C mshA_c.-181G>C 2 upstream_gene_variant 575167 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.-183C>T mshA_c.-183C>T 2 upstream_gene_variant 575165 1 2 0 2 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 7.01573328293188 0.509380354735251 864 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-188G>A mshA_c.-188G>A 2 upstream_gene_variant 575160 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3935 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3159 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.192C>T mshA_c.192C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-194G>T mshA_c.-194G>T 2 upstream_gene_variant 575154 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-195C>A mshA_c.-195C>A 2 upstream_gene_variant 575153 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3978 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3190 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.-197C>T mshA_c.-197C>T 2 upstream_gene_variant 575151 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4019 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3223 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-202A>C mshA_c.-202A>C 2 upstream_gene_variant 575146 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-211C>T mshA_c.-211C>T 2 upstream_gene_variant 575137 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-215C>T mshA_c.-215C>T 2 upstream_gene_variant 575133 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.217C>T mshA_c.217C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.219G>A mshA_c.219G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-219G>C mshA_c.-219G>C 2 upstream_gene_variant 575129 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4029 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.21T>C mshA_c.21T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 188 714 20658 26754 0.00901851674182097 0.00778004260611778 0.0103966638869165 0.974006116207951 0.972055319718155 0.975855750338934 0.208425720620842 0.182351266680503 0.236419583870374 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.341004481955431 0.288531250838499 0.401429696445947 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 165 674 13209 20639 0.0123373710183938 0.0105358583947055 0.0143554651624301 0.968376108478393 0.965938441499649 0.970684896786473 0.196662693682955 0.170275086741914 0.225200189924887 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 1 0.382509969261583 0.320187563694366 0.454838155879156 NA NA NA NA NA NA 27 5) Not assoc w R Now listed Silent mutation no 0 +Isoniazid mshA c.-220C>T mshA_c.-220C>T 2 upstream_gene_variant 575128 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4088 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3277 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-222G>T mshA_c.-222G>T 2 upstream_gene_variant 575126 NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3965 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3177 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.229C>T mshA_c.229C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 8 0 20838 27468 0.000383766669864722 0.000165697303700768 0.000756032532322191 1 0.999865711673152 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 2.24970730189478 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 8 0 13366 21313 0.000598175564528189 0.000258283997825234 0.00117830226263269 1 0.999826933785262 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 2.72130996382454 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-230A>G mshA_c.-230A>G 2 upstream_gene_variant 575118 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4083 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3273 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.231G>C mshA_c.231G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 10 47 20836 27421 0.000479708337330902 0.000230061997553563 0.000882023176671562 0.998288918013688 0.997725265828347 0.998742498754123 0.175438596491228 0.0874732288102737 0.299057659456813 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.280008414242125 0.126104951343262 0.561684411591102 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 8 43 13366 21270 0.000598175564528189 0.000258283997825234 0.00117830226263269 0.997982452024586 0.997283327625553 0.998539517561132 0.156862745098039 0.0702408334573088 0.285876286731559 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.296065337597305 0.12018215777128 0.637320556455271 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-233T>G mshA_c.-233T>G 2 upstream_gene_variant 575115 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.-234G>A mshA_c.-234G>A 2 upstream_gene_variant 575114 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-23G>A mshA_c.-23G>A 2 upstream_gene_variant 575325 1 1 0 1 4 1 20842 27467 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999963594000291 0.999797175631493 0.999999078280314 0.8 0.28358206388191 0.994949236620532 0 0 0.975 0 0 0.975 0 0 51.3582705287504 1 2027.5 5574 False False 5.27147106803569 0.521589398427432 259.279173455301 0 0 0.000176976922618654 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-247A>G mshA_c.-247A>G 2 upstream_gene_variant 575101 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4075 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3266 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.249C>A mshA_c.249C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.252C>T mshA_c.252C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-254A>C mshA_c.-254A>C 2 upstream_gene_variant 575094 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3966 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3178 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.-254A>G mshA_c.-254A>G 2 upstream_gene_variant 575094 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3999 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3205 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.-257G>A mshA_c.-257G>A 2 upstream_gene_variant 575091 1 1 0 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 51.3533466119536 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-260G>A mshA_c.-260G>A 2 upstream_gene_variant 575088 1 11 0 11 0 12 20846 27456 0 0 0.00017694296670111 0.999563128003495 0.99923699702714 0.999774242139628 0 0 0.264648469397051 0 0 0.284914152918154 0 0 0.264648469397051 0 0 0.524850250181136 0.00349739395257092 99 5574 False False 0 0 0.474072891853425 0 0 0.00017694296670111 0.999563128003495 0.99923699702714 0.999774242139628 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 0 11 0 12 13374 21301 0 0 0.000275786657608973 0.999436963355698 0.999016695060306 0.999709037985722 0 0 0.264648469397051 0 0 0.284914152918154 0 0 0.264648469397051 0 0 0.634741511823321 0.00913111943532343 90.5 4479 False False 0 0 0 0 0 0 0 0 0 0.5733410294454 0 0 0.000275786657608973 0.999436963355698 0.999016695060306 0.999709037985722 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-261C>T mshA_c.-261C>T 2 upstream_gene_variant 575087 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.261G>A mshA_c.261G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-262C>A mshA_c.-262C>A 2 upstream_gene_variant 575086 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3969 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3182 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.264C>T mshA_c.264C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.18865318395302 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-265A>G mshA_c.-265A>G 2 upstream_gene_variant 575083 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-268A>G mshA_c.-268A>G 2 upstream_gene_variant 575080 1 0 0 0 1 6 20845 27462 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999781564001747 0.999524617886493 0.999919833755107 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA 0 0 0.4592581264399 NA NA NA NA 4141 5574 False False 0.219573039098105 0.00477770915407814 1.81014820057657 0 0 0.000176951454458875 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 6 13373 21307 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999718481677849 0.999387354605726 0.999896680954833 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA 0 0 0.4592581264399 NA NA NA NA 3316 4479 False False 0 0 0 0 0 0 0 0.265547496198808 0.00577686092206708 2.18912593855065 0 0 0.000275807277411719 0.999718481677849 0.999387354605726 0.999896680954833 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-26C>T mshA_c.-26C>T 2 upstream_gene_variant 575322 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.270C>T mshA_c.270C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-273T>C mshA_c.-273T>C 2 upstream_gene_variant 575075 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.276C>T mshA_c.276C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-278G>A mshA_c.-278G>A 2 upstream_gene_variant 575070 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4030 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3228 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.-285T>G mshA_c.-285T>G 2 upstream_gene_variant 575063 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.288A>C mshA_c.288A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-28C>G mshA_c.-28C>G 2 upstream_gene_variant 575320 NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4117 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-28C>T mshA_c.-28C>T 2 upstream_gene_variant 575320 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-297A>G mshA_c.-297A>G 2 upstream_gene_variant 575051 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3979 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.297G>A mshA_c.297G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.297G>T mshA_c.297G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-299G>A mshA_c.-299G>A 2 upstream_gene_variant 575049 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4142 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3317 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.-299G>C mshA_c.-299G>C 2 upstream_gene_variant 575049 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4102 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3287 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.-29C>T mshA_c.-29C>T 2 upstream_gene_variant 575319 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-2G>A mshA_c.-2G>A 2 upstream_gene_variant 575346 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3150 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-301A>G mshA_c.-301A>G 2 upstream_gene_variant 575047 1 4 0 4 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 1.99597553667858 0.139114336996004 304.5 5574 False False 0 0 1.43785249906968 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.41420404242617 0.305473156458586 444 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-303C>T mshA_c.-303C>T 2 upstream_gene_variant 575045 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.306G>T mshA_c.306G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-309C>T mshA_c.-309C>T 2 upstream_gene_variant 575039 NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4007 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.315C>T mshA_c.315C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-315C>T mshA_c.-315C>T 2 upstream_gene_variant 575033 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4037 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3233 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.318G>C mshA_c.318G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.99604811372315 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.41420404242617 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.318G>T mshA_c.318G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.322C>T mshA_c.322C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-330C>T mshA_c.-330C>T 2 upstream_gene_variant 575018 1 4 0 4 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 1.99604811372315 0.139118032244638 322.5 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.41420404242617 0.305473156458586 444 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-338G>A mshA_c.-338G>A 2 upstream_gene_variant 575010 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4031 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3229 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.339G>A mshA_c.339G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-342C>T mshA_c.-342C>T 2 upstream_gene_variant 575006 NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3913 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3141 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.342G>T mshA_c.342G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.18865318395302 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.85651838973546 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-347G>A mshA_c.-347G>A 2 upstream_gene_variant 575001 NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4123 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3304 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.348C>G mshA_c.348C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.348C>T mshA_c.348C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-34C>T mshA_c.-34C>T 2 upstream_gene_variant 575314 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.351C>T mshA_c.351C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 2 20844 27466 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999927188000582 0.999737003036386 0.999991182007438 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.3176933410094 0.0955278435529395 18.1762534351792 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-351C>T mshA_c.-351C>T 2 upstream_gene_variant 574997 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-354G>A mshA_c.-354G>A 2 upstream_gene_variant 574994 1 4 0 4 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 1.99604811372315 0.139118032244638 322.5 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-354G>C mshA_c.-354G>C 2 upstream_gene_variant 574994 1 3 0 3 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18880616510555 0.264079043314886 541.5 5574 False False 0.439194051331254 0.00837049629364692 5.4704842261679 0 0 0.000176951454458875 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 3 13373 21310 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999859240838924 0.999588697652472 0.999970971136275 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85680682534852 0.289279625558287 389.5 4479 False False 0 0 0 0 0 0 0 0.531169769934445 0.010122018243966 6.61631049307563 0 0 0.000275807277411719 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-368C>T mshA_c.-368C>T 2 upstream_gene_variant 574980 1 0 0 0 0 8 20846 27460 0 0 0.00017694296670111 0.99970875200233 0.999426206431739 0.999874251669172 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 4103 5574 False False 0 0 0.771808536885009 0 0 0.00017694296670111 0.99970875200233 0.999426206431739 0.999874251669172 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 8 13374 21305 0 0 0.000275786657608973 0.999624642237132 0.999260530264256 0.999837933676441 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 3288 4479 False False 0 0 0 0 0 0 0 0 0 0.93343997011793 0 0 0.000275786657608973 0.999624642237132 0.999260530264256 0.999837933676441 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-369G>A mshA_c.-369G>A 2 upstream_gene_variant 574979 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.372C>T mshA_c.372C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 6 20845 27462 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999781564001747 0.999524617886493 0.999919833755107 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.219573039098105 0.00477770915407814 1.81014820057657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 5 13373 21308 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999765401398207 0.999452610763328 0.999923822225278 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.318671950945935 0.00674139558547252 2.84834809554519 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-377G>T mshA_c.-377G>T 2 upstream_gene_variant 574971 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-378A>C mshA_c.-378A>C 2 upstream_gene_variant 574970 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3884 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3118 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-381G>A mshA_c.-381G>A 2 upstream_gene_variant 574967 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4089 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3278 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.-387T>C mshA_c.-387T>C 2 upstream_gene_variant 574961 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4053 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3248 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-394G>T mshA_c.-394G>T 2 upstream_gene_variant 574954 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4104 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3289 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.396C>T mshA_c.396C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-399G>A mshA_c.-399G>A 2 upstream_gene_variant 574949 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-39C>A mshA_c.-39C>A 2 upstream_gene_variant 575309 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4000 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3206 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.402C>T mshA_c.402C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.405G>A mshA_c.405G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-406T>G mshA_c.-406T>G 2 upstream_gene_variant 574942 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-407C>T mshA_c.-407C>T 2 upstream_gene_variant 574941 1 1 0 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 51.3533466119536 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.414C>T mshA_c.414C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 5 9 20841 27459 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.999672346002621 0.99937810218515 0.999850165132458 0.357142857142857 0.127598429859159 0.648619889384008 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.731970634806391 0.192681152309073 2.43252804051037 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 4 8 13370 21305 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 0.999624642237132 0.999260530264256 0.999837933676441 0.333333333333333 0.0992460911495833 0.651124493581186 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.796746447270007 0.175554888158817 2.97493777258165 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-415C>T mshA_c.-415C>T 2 upstream_gene_variant 574933 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.-419A>G mshA_c.-419A>G 2 upstream_gene_variant 574929 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3936 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3160 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.-420C>T mshA_c.-420C>T 2 upstream_gene_variant 574928 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-421C>T mshA_c.-421C>T 2 upstream_gene_variant 574927 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-424C>T mshA_c.-424C>T 2 upstream_gene_variant 574924 NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3953 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-426T>C mshA_c.-426T>C 2 upstream_gene_variant 574922 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3980 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3191 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.-426T>G mshA_c.-426T>G 2 upstream_gene_variant 574922 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-427C>T mshA_c.-427C>T 2 upstream_gene_variant 574921 1 0 0 0 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3923 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3151 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-428G>A mshA_c.-428G>A 2 upstream_gene_variant 574920 1 1 0 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 51.3533466119536 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-434G>A mshA_c.-434G>A 2 upstream_gene_variant 574914 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4020 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.435G>T mshA_c.435G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.63548263289195 0.137183409715989 155.34952410964 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-435T>G mshA_c.-435T>G 2 upstream_gene_variant 574913 NA 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4008 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3212 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-436G>A mshA_c.-436G>A 2 upstream_gene_variant 574912 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4143 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3318 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.-438C>A mshA_c.-438C>A 2 upstream_gene_variant 574910 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3885 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-439C>T mshA_c.-439C>T 2 upstream_gene_variant 574909 1 0 0 0 4 1 20842 27467 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999963594000291 0.999797175631493 0.999999078280314 0.8 0.28358206388191 0.994949236620532 NA NA NA 0 0 0.975 NA NA NA NA 4038 5574 False False 5.27147106803569 0.521589398427432 259.279173455301 0 0 0.000176976922618654 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3234 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.-43C>T mshA_c.-43C>T 2 upstream_gene_variant 575305 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4132 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3312 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-442G>A mshA_c.-442G>A 2 upstream_gene_variant 574906 1 6 0 6 7 6 20839 27462 0.000335795836131632 0.000135017659185429 0.000691744589626827 0.999781564001747 0.999524617886493 0.999919833755107 0.538461538461538 0.251345482270303 0.807767558198712 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.11938510070218 0.0402329152731912 215 5574 False False 1.53745381256298 0.442344590021336 5.538005054617 0 0 0.00017700239811062 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 7 4 13367 21309 0.000523403618962165 0.000210460468745924 0.00107811225334149 0.999812321118566 0.999519537882235 0.999948861529775 0.636363636363636 0.307904715011677 0.890736556180901 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.41546946667532 0.305452349285709 420 4479 False False 0 0 0 0 0 0 0 2.78976210069574 0.709037913467221 12.9963385770797 0 0 0.000275931061008045 0.999812321118566 0.999519537882235 0.999948861529775 1 3) Uncertain significance No change no 1 +Isoniazid mshA c.-443C>T mshA_c.-443C>T 2 upstream_gene_variant 574905 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.444C>T mshA_c.444C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-445C>T mshA_c.-445C>T 2 upstream_gene_variant 574903 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-447G>A mshA_c.-447G>A 2 upstream_gene_variant 574901 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4047 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3242 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-448G>A mshA_c.-448G>A 2 upstream_gene_variant 574900 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4090 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3279 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.-448G>C mshA_c.-448G>C 2 upstream_gene_variant 574900 1 11 0 11 1 20 20845 27448 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999271880005825 0.998875700613314 0.999555190458412 0.0476190476190476 0.00120488344836351 0.238159909936821 0 0 0.284914152918154 0 0 0.168433470983085 0 0 0.524722571685263 0.00349701444015072 94 5574 False False 0.0658383305349004 0.00159270996657629 0.411717550396138 0 0 0.000176951454458875 0.999271880005825 0.998875700613314 0.999555190458412 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 1 19 13373 21294 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999108525313189 0.998608200368116 0.999463191365845 0.05 0.0012650894979498 0.248732762772027 0 0 0.30849710781876 0 0 0.176466911806965 0 0 0.710518711899053 0.0088832400007765 71 4479 False False 0 0 0 0 0 0 0 0.083805940484952 0.00202102923518229 0.527304721809187 0 0 0.000275807277411719 0.999108525313189 0.998608200368116 0.999463191365845 3 3) Uncertain significance No change no 1 +Isoniazid mshA c.-44G>A mshA_c.-44G>A 2 upstream_gene_variant 575304 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.-44G>C mshA_c.-44G>C 2 upstream_gene_variant 575304 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.450C>T mshA_c.450C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 6 20845 27462 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999781564001747 0.999524617886493 0.999919833755107 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.219573039098105 0.00477770915407814 1.81014820057657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 5 13373 21308 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999765401398207 0.999452610763328 0.999923822225278 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.318671950945935 0.00674139558547252 2.84834809554519 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.453G>A mshA_c.453G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-453T>G mshA_c.-453T>G 2 upstream_gene_variant 574895 1 2 0 2 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01632529799099 0.509386028876591 1135.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48598624162872 0.526186417038858 925 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-454C>T mshA_c.-454C>T 2 upstream_gene_variant 574894 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.456C>T mshA_c.456C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.45G>A mshA_c.45G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-460G>A mshA_c.-460G>A 2 upstream_gene_variant 574888 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-461G>A mshA_c.-461G>A 2 upstream_gene_variant 574887 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-462C>T mshA_c.-462C>T 2 upstream_gene_variant 574886 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.471G>A mshA_c.471G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 2 20844 27466 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999927188000582 0.999737003036386 0.999991182007438 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.3176933410094 0.0955278435529395 18.1762534351792 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-474G>C mshA_c.-474G>C 2 upstream_gene_variant 574874 1 0 0 0 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3924 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3152 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-476C>T mshA_c.-476C>T 2 upstream_gene_variant 574872 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-477G>A mshA_c.-477G>A 2 upstream_gene_variant 574871 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3981 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3192 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.-479C>T mshA_c.-479C>T 2 upstream_gene_variant 574869 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4124 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3305 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.-480C>T mshA_c.-480C>T 2 upstream_gene_variant 574868 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.-484C>T mshA_c.-484C>T 2 upstream_gene_variant 574864 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4076 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3267 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-485G>T mshA_c.-485G>T 2 upstream_gene_variant 574863 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.486C>T mshA_c.486C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.869878292971449 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 4 0 13370 21313 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 1 0.999826933785262 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.05210128917758 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-486T>C mshA_c.-486T>C 2 upstream_gene_variant 574862 1 1 1 0 77 0 20769 27468 0.00369375419744795 0.00291611938263168 0.0046144276426553 1 0.999865711673152 1 1 0.953221931839596 1 1 0.025 1 1 0.025 1 Inf 0.0339095864028356 Inf 0.430573406857664 589 5574 False False Inf 26.9375808756508 Inf 4.81463649494463e-05 1.21895967999967e-06 0.000268224855462147 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 21 0 13353 21313 0.00157021085688649 0.000972239812025402 0.00239923787401666 1 0.999826933785262 1 1 0.83890238478092 1 NA NA NA NA NA NA NA NA NA NA 3174 4479 False False 0 0 0 0 0 0 0 Inf 8.30942270480458 Inf 0 0 0.000276220321944213 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.-486T>G mshA_c.-486T>G 2 upstream_gene_variant 574862 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4133 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.48C>T mshA_c.48C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.439194051331254 0.00837049629364692 5.4704842261679 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 3 13373 21310 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999859240838924 0.999588697652472 0.999970971136275 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.531169769934445 0.010122018243966 6.61631049307563 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.490C>T mshA_c.490C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 80 0 20766 27468 0.00383766669864722 0.00304416848759615 0.00477406540290361 1 0.999865711673152 1 1 0.954935964932307 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 28.0425773476356 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 17 0 13357 21313 0.0012711230746224 0.000740644897312986 0.00203441363276193 1 0.999826933785262 1 1 0.804935677030906 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 6.58228232638527 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-491G>A mshA_c.-491G>A 2 upstream_gene_variant 574857 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4144 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3319 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.498C>T mshA_c.498C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-500G>A mshA_c.-500G>A 2 upstream_gene_variant 574848 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4001 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3207 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.504C>T mshA_c.504C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 1 20842 27467 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999963594000291 0.999797175631493 0.999999078280314 0.8 0.28358206388191 0.994949236620532 NA NA NA NA NA NA NA NA NA NA NA NA False False 5.27147106803569 0.521589398427432 259.279173455301 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-506G>A mshA_c.-506G>A 2 upstream_gene_variant 574842 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-512G>A mshA_c.-512G>A 2 upstream_gene_variant 574836 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-513T>C mshA_c.-513T>C 2 upstream_gene_variant 574835 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4105 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3290 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-515A>G mshA_c.-515A>G 2 upstream_gene_variant 574833 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-518T>C mshA_c.-518T>C 2 upstream_gene_variant 574830 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-518T>G mshA_c.-518T>G 2 upstream_gene_variant 574830 1 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4134 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3313 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-521G>A mshA_c.-521G>A 2 upstream_gene_variant 574827 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3886 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3119 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-524C>T mshA_c.-524C>T 2 upstream_gene_variant 574824 1 0 0 0 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4021 5574 False False 0.439194051331254 0.00837049629364692 5.4704842261679 0 0 0.000176951454458875 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-527C>T mshA_c.-527C>T 2 upstream_gene_variant 574821 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3970 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3183 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.-528G>T mshA_c.-528G>T 2 upstream_gene_variant 574820 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-529G>A mshA_c.-529G>A 2 upstream_gene_variant 574819 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3906 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3135 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-530G>A mshA_c.-530G>A 2 upstream_gene_variant 574818 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-535G>T mshA_c.-535G>T 2 upstream_gene_variant 574813 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4039 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.-537C>T mshA_c.-537C>T 2 upstream_gene_variant 574811 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.537G>T mshA_c.537G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-539G>C mshA_c.-539G>C 2 upstream_gene_variant 574809 1 2 1 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.31767810026385 0.0167927522337569 103.35711725526 1 1253.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-539G>T mshA_c.-539G>T 2 upstream_gene_variant 574809 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4054 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3249 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.-545A>G mshA_c.-545A>G 2 upstream_gene_variant 574803 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-545A>T mshA_c.-545A>T 2 upstream_gene_variant 574803 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.54G>A mshA_c.54G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 2 20844 27466 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999927188000582 0.999737003036386 0.999991182007438 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.3176933410094 0.0955278435529395 18.1762534351792 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 2 13372 21311 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999906160559283 0.999661061221376 0.999988635406343 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59370326054442 0.115491055908661 21.9865025501046 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-552C>G mshA_c.-552C>G 2 upstream_gene_variant 574796 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-552C>T mshA_c.-552C>T 2 upstream_gene_variant 574796 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-553A>G mshA_c.-553A>G 2 upstream_gene_variant 574795 1 0 0 0 1 11 20845 27457 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999599534003203 0.9992835689522 0.999800072407065 0.0833333333333333 0.00210759323186022 0.384796165150944 NA NA NA 0 0 0.284914152918154 NA NA NA NA 3937 5574 False False 0.119745306264855 0.00278612189885952 0.824021419435307 0 0 0.000176951454458875 0.999599534003203 0.9992835689522 0.999800072407065 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 11 13373 21302 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999483883076056 0.999076712346733 0.999742329032819 0.0833333333333333 0.00210759323186022 0.384796165150944 NA NA NA 0 0 0.284914152918154 NA NA NA NA 3161 4479 False False 0 0 0 0 0 0 0 0.144810099046246 0.00336819644582784 0.996572767671761 0 0 0.000275807277411719 0.999483883076056 0.999076712346733 0.999742329032819 1 3) Uncertain significance No change no 1 +Isoniazid mshA c.555C>T mshA_c.555C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-560C>T mshA_c.-560C>T 2 upstream_gene_variant 574788 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.561A>C mshA_c.561A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-561G>A mshA_c.-561G>A 2 upstream_gene_variant 574787 1 1 0 1 3 2 20843 27466 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999927188000582 0.999737003036386 0.999991182007438 0.6 0.146632799634673 0.947255049473683 0 0 0.975 0 0 0.841886116991581 0 0 51.3539402930048 1 2027.5 5574 False False 1.97663484143357 0.226402568392661 23.6672561646805 0 0 0.00017696843241753 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 3 1 13371 21312 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999953080279641 0.999738608085756 0.999998812096234 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 3213 4479 False False 0 0 0 0 0 0 0 4.78169172088849 0.383875689805931 250.696170545132 0 0 0.000275848526268708 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.564G>A mshA_c.564G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-565C>G mshA_c.-565C>G 2 upstream_gene_variant 574783 1 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3895 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3125 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance No change no 1 +Isoniazid mshA c.-566C>T mshA_c.-566C>T 2 upstream_gene_variant 574782 1 6 0 6 1 6 20845 27462 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999781564001747 0.999524617886493 0.999919833755107 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.11906289991934 0.040214073694581 205 5574 False False 0.219573039098105 0.00477770915407814 1.81014820057657 0 0 0.000176951454458875 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 1 6 13373 21307 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999718481677849 0.999387354605726 0.999896680954833 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.35345678111722 0.0884835334370246 175 4479 False False 0 0 0 0 0 0 0 0.265547496198808 0.00577686092206708 2.18912593855065 0 0 0.000275807277411719 0.999718481677849 0.999387354605726 0.999896680954833 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.567C>A mshA_c.567C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-567G>T mshA_c.-567G>T 2 upstream_gene_variant 574781 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4040 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3235 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-568C>T mshA_c.-568C>T 2 upstream_gene_variant 574780 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.-570C>T mshA_c.-570C>T 2 upstream_gene_variant 574778 1 2 0 2 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01632529799099 0.509386028876591 1135.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48598624162872 0.526186417038858 925 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.573C>T mshA_c.573C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 15 20845 27453 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999453910004368 0.999099467294252 0.999694326386446 0.0625 0.00158111172276588 0.302320738434531 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.0878004317582154 0.00208981885650849 0.570795388928157 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 15 13373 21298 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999296204194623 0.998839461100611 0.999606039023746 0.0625 0.00158111172276588 0.302320738434531 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.106174131957426 0.00252607251575667 0.690295349767496 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-573C>T mshA_c.-573C>T 2 upstream_gene_variant 574775 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-574C>A mshA_c.-574C>A 2 upstream_gene_variant 574774 NA 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3988 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3197 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.-574C>G mshA_c.-574C>G 2 upstream_gene_variant 574774 1 1 0 1 7 1 20839 27467 0.000335795836131632 0.000135017659185429 0.000691744589626827 0.999963594000291 0.999797175631493 0.999999078280314 0.875 0.473490329124793 0.996840276468748 0 0 0.975 0 0 0.975 0 0 51.3656581746512 1 2027.5 5574 False False 9.22640241854215 1.18513781610454 415.029346412368 0 0 0.00017700239811062 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 7 0 13367 21313 0.000523403618962165 0.000210460468745924 0.00107811225334149 1 0.999826933785262 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 3184 4479 False False 0 0 0 0 0 0 0 Inf 2.29755378883993 Inf 0 0 0.000275931061008045 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-574C>T mshA_c.-574C>T 2 upstream_gene_variant 574774 NA 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4118 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-576C>T mshA_c.-576C>T 2 upstream_gene_variant 574772 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3887 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3120 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.-579C>A mshA_c.-579C>A 2 upstream_gene_variant 574769 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-579C>T mshA_c.-579C>T 2 upstream_gene_variant 574769 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3944 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.582C>T mshA_c.582C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.18865318395302 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-582T>C mshA_c.-582T>C 2 upstream_gene_variant 574766 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-582T>G mshA_c.-582T>G 2 upstream_gene_variant 574766 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4072 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3263 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.-585T>C mshA_c.-585T>C 2 upstream_gene_variant 574763 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.-588C>T mshA_c.-588C>T 2 upstream_gene_variant 574760 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4145 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3320 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-589C>G mshA_c.-589C>G 2 upstream_gene_variant 574759 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-58C>T mshA_c.-58C>T 2 upstream_gene_variant 575290 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4064 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3255 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.-590G>A mshA_c.-590G>A 2 upstream_gene_variant 574758 1 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4077 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3268 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-591G>C mshA_c.-591G>C 2 upstream_gene_variant 574757 NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3975 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.-59G>A mshA_c.-59G>A 2 upstream_gene_variant 575289 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.600G>A mshA_c.600G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-600G>A mshA_c.-600G>A 2 upstream_gene_variant 574748 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.603C>A mshA_c.603C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-605C>A mshA_c.-605C>A 2 upstream_gene_variant 574743 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3971 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3185 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.60C>T mshA_c.60C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-60G>C mshA_c.-60G>C 2 upstream_gene_variant 575288 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-614A>C mshA_c.-614A>C 2 upstream_gene_variant 574734 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.618C>G mshA_c.618C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-620C>T mshA_c.-620C>T 2 upstream_gene_variant 574728 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-622C>T mshA_c.-622C>T 2 upstream_gene_variant 574726 NA 0 0 0 2 2 20844 27466 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999927188000582 0.999737003036386 0.999991182007438 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3938 5574 False False 1.3176933410094 0.0955278435529395 18.1762534351792 0 0 0.000176959943030976 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3162 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-623G>A mshA_c.-623G>A 2 upstream_gene_variant 574725 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-629G>T mshA_c.-629G>T 2 upstream_gene_variant 574719 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3989 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.-630A>C mshA_c.-630A>C 2 upstream_gene_variant 574718 NA 0 0 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3907 5574 False False Inf 0.869878292971449 Inf 0 0 0.000176976922618654 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3136 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.630G>T mshA_c.630G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-632G>A mshA_c.-632G>A 2 upstream_gene_variant 574716 1 0 0 0 4 1 20842 27467 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999963594000291 0.999797175631493 0.999999078280314 0.8 0.28358206388191 0.994949236620532 NA NA NA 0 0 0.975 NA NA NA NA 4135 5574 False False 5.27147106803569 0.521589398427432 259.279173455301 0 0 0.000176976922618654 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 1 13371 21312 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999953080279641 0.999738608085756 0.999998812096234 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 62.1055547471297 1 1642.5 4479 False False 0 0 0 0 0 0 0 4.78169172088849 0.383875689805931 250.696170545132 0 0 0.000275848526268708 0.999953080279641 0.999738608085756 0.999998812096234 10 3) Uncertain significance No change no 1 +Isoniazid mshA c.-633C>T mshA_c.-633C>T 2 upstream_gene_variant 574715 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4106 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3291 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.-63G>T mshA_c.-63G>T 2 upstream_gene_variant 575285 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-642C>T mshA_c.-642C>T 2 upstream_gene_variant 574706 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3888 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3121 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-643C>T mshA_c.-643C>T 2 upstream_gene_variant 574705 1 3 0 3 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.18853708762714 0.264070532102877 442 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.85633740727807 0.289259828934126 294 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-644G>T mshA_c.-644G>T 2 upstream_gene_variant 574704 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4091 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3280 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.-646A>T mshA_c.-646A>T 2 upstream_gene_variant 574702 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4107 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3292 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-64C>A mshA_c.-64C>A 2 upstream_gene_variant 575284 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4022 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-64C>T mshA_c.-64C>T 2 upstream_gene_variant 575284 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-650G>A mshA_c.-650G>A 2 upstream_gene_variant 574698 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-651C>T mshA_c.-651C>T 2 upstream_gene_variant 574697 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-65C>G mshA_c.-65C>G 2 upstream_gene_variant 575283 1 68 3 65 19 80 20827 27388 0.000911445840928715 0.000548836318218138 0.00142297127227785 0.997087520023299 0.996376458242384 0.997689929573139 0.191919191919191 0.119684354393664 0.283367629217074 0.0441176470588235 0.00919219520278738 0.123562624331778 0.036144578313253 0.00751682023519663 0.102014882335761 0.0606934046411647 0.012203540171658 0.185414432324663 5.74280239554539e-13 12 5574 True False 0.312318144715993 0.178726997641545 0.520180251033156 0.000144023043686989 2.97019989197563e-05 0.000420838186784513 0.997087520023299 0.996376458242384 0.997689929573139 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 41 2 39 11 47 13363 21266 0.000822491401226259 0.000410653977896139 0.00147118664271154 0.997794773143152 0.997068582412381 0.998379246067552 0.189655172413793 0.0986638168420868 0.314050861593841 0.048780487804878 0.00596311824104283 0.16533335341783 0.0408163265306122 0.0049818418349713 0.139787187022463 0.0816107238317819 0.00954073302358793 0.315315963462652 1.03045965847759e-06 21 4479 True False 0 0 0 0 0 0 0 0.372457452381217 0.174146310161706 0.728941425014472 0.000149644594089038 1.81231683879501e-05 0.000540462076832832 0.997794773143152 0.997068582412381 0.998379246067552 19 3) Uncertain significance No change no 1 +Isoniazid mshA c.-65C>T mshA_c.-65C>T 2 upstream_gene_variant 575283 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-660G>A mshA_c.-660G>A 2 upstream_gene_variant 574688 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4048 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3243 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-660G>C mshA_c.-660G>C 2 upstream_gene_variant 574688 NA 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4119 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3300 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-662A>G mshA_c.-662A>G 2 upstream_gene_variant 574686 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3896 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3126 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-665T>C mshA_c.-665T>C 2 upstream_gene_variant 574683 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4009 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3214 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-667C>T mshA_c.-667C>T 2 upstream_gene_variant 574681 1 4 0 4 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 1.99604811372315 0.139118032244638 322.5 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 1 3) Uncertain significance No change no 1 +Isoniazid mshA c.-669C>G mshA_c.-669C>G 2 upstream_gene_variant 574679 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-669C>T mshA_c.-669C>T 2 upstream_gene_variant 574679 NA 0 0 0 3 1 20843 27467 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999963594000291 0.999797175631493 0.999999078280314 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 4010 5574 False False 3.95341361608213 0.31739219148065 207.323829234655 0 0 0.00017696843241753 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3215 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-66C>G mshA_c.-66C>G 2 upstream_gene_variant 575282 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-66C>T mshA_c.-66C>T 2 upstream_gene_variant 575282 1 22 0 22 6 28 20840 27440 0.000287825002398541 0.000105633792978048 0.000626367784710498 0.998980632008154 0.998527063823414 0.999322533833553 0.176470588235294 0.0676406526827571 0.345315131068133 0 0 0.154372512815574 0 0 0.123436118500263 0 0 0.240409575930085 8.00335997286817e-06 45 5574 True False 0.28214971209213 0.095500435202178 0.694682677472857 0 0 0.000176993905465082 0.998980632008154 0.998527063823414 0.999322533833553 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 12 0 12 5 15 13369 21298 0.000373859727830118 0.000121402023062639 0.000872246401868143 0.999296204194623 0.998839461100611 0.999606039023746 0.25 0.0865714691014345 0.491045871707957 0 0 0.264648469397051 0 0 0.218019360910534 0 0 0.573474744088317 0.00491564727271325 67 4479 False False 0 0 0 0 0 0 0 0.531029496097938 0.150948940794162 1.53751234566307 0 0 0.000275889787465637 0.999296204194623 0.998839461100611 0.999606039023746 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.678G>A mshA_c.678G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-67C>T mshA_c.-67C>T 2 upstream_gene_variant 575281 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.687T>C mshA_c.687T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-68G>A mshA_c.-68G>A 2 upstream_gene_variant 575280 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.696G>A mshA_c.696G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-70C>A mshA_c.-70C>A 2 upstream_gene_variant 575278 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.720C>T mshA_c.720C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.730C>T mshA_c.730C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 400 376 20446 27092 0.0191883334932361 0.0173693389301239 0.0211430980442473 0.986311344109509 0.984866389505464 0.987652030685314 0.515463917525773 0.479655318027012 0.551154606622638 NA NA NA NA NA NA NA NA NA NA NA NA False True 1.40962910083853 1.21994838717834 1.62902909762267 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 246 275 13128 21038 0.0183938986092418 0.0161844573499836 0.0208162668166989 0.987097076901421 0.985490227263625 0.988568945825707 0.472168905950096 0.428605275952612 0.516049941822596 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 1 1.4335349842114 1.20033552930165 1.71129727234042 NA NA NA NA NA NA 57 5) Not assoc w R Now listed Silent mutation no 0 +Isoniazid mshA c.738G>A mshA_c.738G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.738G>C mshA_c.738G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-73A>G mshA_c.-73A>G 2 upstream_gene_variant 575275 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.741C>T mshA_c.741C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.18865318395302 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.85651838973546 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.747G>A mshA_c.747G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-74G>A mshA_c.-74G>A 2 upstream_gene_variant 575274 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3945 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.775C>T mshA_c.775C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.781C>T mshA_c.781C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 3 20842 27465 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999890782000873 0.99968085216583 0.999977476056514 0.571428571428571 0.184051567640083 0.901011721557492 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.75702907590442 0.297192930207644 11.9979296337129 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.78C>G mshA_c.78C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-78G>T mshA_c.-78G>T 2 upstream_gene_variant 575270 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.795G>A mshA_c.795G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-80_-76delCTGCA mshA_c.-80_-76delCTGCA 2 upstream_gene_variant 575267 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3946 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.801G>T mshA_c.801G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.813C>T mshA_c.813C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 12 2 20834 27466 0.000575650004797083 0.000297481006307132 0.00100532857413147 0.999927188000582 0.999737003036386 0.999991182007438 0.857142857142857 0.571870839090301 0.982205484516808 NA NA NA NA NA NA NA NA NA NA NA NA False False 7.90995488144379 1.76059658175354 72.6312693760519 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 12 2 13362 21311 0.000897263346792283 0.000463712283458933 0.00156681338714949 0.999906160559283 0.999661061221376 0.999988635406343 0.857142857142857 0.571870839090301 0.982205484516808 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 9.56937584193982 2.12973146192549 88.124964766194 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.819C>T mshA_c.819C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.829C>T mshA_c.829C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 11 20845 27457 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999599534003203 0.9992835689522 0.999800072407065 0.0833333333333333 0.00210759323186022 0.384796165150944 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.119745306264855 0.00278612189885952 0.824021419435307 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 10 13373 21303 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999530802796415 0.99913729947772 0.999774979505452 0.0909090909090909 0.00229897221381426 0.412779916988382 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.159298586704553 0.00367454063771155 1.12000806973243 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-83C>T mshA_c.-83C>T 2 upstream_gene_variant 575265 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.840C>T mshA_c.840C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.84C>T mshA_c.84C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-84C>T mshA_c.-84C>T 2 upstream_gene_variant 575264 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4041 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3236 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.852G>A mshA_c.852G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.855T>C mshA_c.855T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.858G>C mshA_c.858G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.873C>T mshA_c.873C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.87C>T mshA_c.87C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 8 20845 27460 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.99970875200233 0.999426206431739 0.999874251669172 0.111111111111111 0.00280913674659921 0.482496514917337 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.164667786039817 0.00371513512243138 1.22846047298172 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 8 13374 21305 0 0 0.000275786657608973 0.999624642237132 0.999260530264256 0.999837933676441 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.93343997011793 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.894C>T mshA_c.894C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.897C>T mshA_c.897C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.903G>A mshA_c.903G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.912C>T mshA_c.912C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.916C>T mshA_c.916C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.927G>T mshA_c.927G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.930C>T mshA_c.930C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.933A>C mshA_c.933A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.934C>T mshA_c.934C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-93G>A mshA_c.-93G>A 2 upstream_gene_variant 575255 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-93G>T mshA_c.-93G>T 2 upstream_gene_variant 575255 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.940C>A mshA_c.940C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.948C>T mshA_c.948C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.955C>T mshA_c.955C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 4 20845 27464 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999854376001165 0.999627187086024 0.999960320981843 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.329383545214679 0.00669260119676484 3.32889360843958 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.41420404242617 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.963C>T mshA_c.963C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.18865318395302 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.969A>C mshA_c.969A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 4 20845 27464 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999854376001165 0.999627187086024 0.999960320981843 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.329383545214679 0.00669260119676484 3.32889360843958 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.85651838973546 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.969A>G mshA_c.969A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 7 20842 27461 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999745158002038 0.999474999027776 0.999897534357495 0.363636363636363 0.109263443819098 0.692095284988322 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.752902792438345 0.161601315405925 2.9620720115734 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 5 13371 21308 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999765401398207 0.999452610763328 0.999923822225278 0.375 0.0852334141372535 0.755136783633448 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.956158851245232 0.148446407940978 4.91535926753262 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-96C>A mshA_c.-96C>A 2 upstream_gene_variant 575252 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3908 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3137 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.-96C>T mshA_c.-96C>T 2 upstream_gene_variant 575252 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.-97G>A mshA_c.-97G>A 2 upstream_gene_variant 575251 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4108 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3293 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA c.981T>C mshA_c.981T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.987G>A mshA_c.987G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.990G>A mshA_c.990G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA c.-9C>T mshA_c.-9C>T 2 upstream_gene_variant 575339 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid mshA c.9T>C mshA_c.9T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid mshA deletion mshA_deletion 2 feature_ablation (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4125 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3306 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA LoF mshA_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 3 1 2 66 3 20780 27465 0.00316607502638395 0.00244946268622404 0.00402628691816945 0.999890782000873 0.99968085216583 0.999977476056514 0.956521739130434 0.878152850634376 0.990942392641185 0.333333333333333 0.00840375865961264 0.905700675949754 0.25 0.00630946320970987 0.805879550316756 0.660851780558229 0.0112063726400259 12.695865727797 1 2027.5 5574 False False 29.077478344562 9.52448384860962 144.701921716442 4.81208796496799e-05 1.21831444886007e-06 0.000268082891703147 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 37 1 13337 21312 0.00276656198594287 0.00194864015550479 0.00381134478706768 0.999953080279641 0.999738608085756 0.999998812096234 0.973684210526315 0.861900970207579 0.999333963795797 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.59796056084576 0.0203553509520822 125.320826988663 1 1642.5 4479 False False 0 0 0 0 0 0 0 59.1245407512933 9.9720212610516 2368.94566990575 7.49737591842855e-05 1.89816943736224e-06 0.000417655468224933 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Ala104fs mshA_p.Ala104fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4055 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3250 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Ala114Val mshA_p.Ala114Val 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 4 20845 27464 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999854376001165 0.999627187086024 0.999960320981843 0.2 0.00505076337946806 0.716417936118089 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4109 5574 False False 0.329383545214679 0.00669260119676484 3.32889360843958 0 0 0.000176951454458875 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 4 13373 21309 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999812321118566 0.999519537882235 0.999948861529775 0.2 0.00505076337946806 0.716417936118089 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3294 4479 False False 0 0 0 0 0 0 0 0.398358633066626 0.00809276091420046 4.02622197901862 0 0 0.000275807277411719 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Ala131Val mshA_p.Ala131Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Ala133Thr mshA_p.Ala133Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4126 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3307 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Ala134Thr mshA_p.Ala134Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 0 8 20846 27460 0 0 0.00017694296670111 0.99970875200233 0.999426206431739 0.999874251669172 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.771808536885009 0.0121106507453556 124 5574 False False 0 0 0.771808536885009 0 0 0.00017694296670111 0.99970875200233 0.999426206431739 0.999874251669172 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 0 8 13374 21305 0 0 0.000275786657608973 0.999624642237132 0.999260530264256 0.999837933676441 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.93343997011793 0.0270142859619197 118.5 4479 False False 0 0 0 0 0 0 0 0 0 0.93343997011793 0 0 0.000275786657608973 0.999624642237132 0.999260530264256 0.999837933676441 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Ala134Val mshA_p.Ala134Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 4 20843 27464 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999854376001165 0.999627187086024 0.999960320981843 0.428571428571428 0.0989882784425078 0.815948432359917 0 0 0.975 0 0 0.602364635616474 0 0 51.3502039740317 1 2027.5 5574 False False 0.988245454109293 0.144734627190883 5.84310835075667 0 0 0.00017696843241753 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 4 13371 21309 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999812321118566 0.999519537882235 0.999948861529775 0.428571428571428 0.0989882784425078 0.815948432359917 0 0 0.975 0 0 0.602364635616474 0 0 62.096821303311 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.19525465559793 0.17505505093835 7.0663575727929 0 0 0.000275848526268708 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Ala139Thr mshA_p.Ala139Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3897 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3127 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Ala165Thr mshA_p.Ala165Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Ala177Thr mshA_p.Ala177Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3947 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3167 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Ala182Thr mshA_p.Ala182Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 30 2 28 12 37 20834 27431 0.000575650004797083 0.000297481006307132 0.00100532857413147 0.998652978010776 0.998143780847516 0.999051400373341 0.244897959183673 0.133428710842293 0.388695914688433 0.0666666666666666 0.00817813446065631 0.220735401522961 0.0512820512820512 0.00627197209569041 0.173244781373605 0.0940461333808746 0.0108536584951153 0.373051815728439 1.93163524467271e-05 48 5574 True False 0.427020281296944 0.202701701771473 0.837446212180556 9.59877135726627e-05 1.16247688225948e-05 0.00034669715486346 0.998652978010776 0.998143780847516 0.999051400373341 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 24 1 23 10 32 13364 21281 0.000747719455660236 0.000358616922835118 0.00137465137870696 0.998498568948529 0.997881082537686 0.998972802621471 0.238095238095238 0.120516186492179 0.394502429021575 0.0416666666666666 0.00105435244546974 0.211201683456973 0.0303030303030303 0.000766912075048109 0.157593972272496 0.0692353239722551 0.00168485597831869 0.426466737136328 0.000193831603970738 40 4479 True False 0 0 0 0 0 0 0 0.497628891050583 0.218131568914901 1.03792675799626 7.48222970445192e-05 1.89433475526229e-06 0.000416811864107337 0.998498568948529 0.997881082537686 0.998972802621471 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Ala187Thr mshA_p.Ala187Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 2 9 20844 27459 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999672346002621 0.99937810218515 0.999850165132458 0.181818181818181 0.0228311982999596 0.517755852360172 0 0 0.521823750104981 0 0 0.336267116879942 0 0 1.43778082538293 0.0743338171288217 233 5574 False False 0.292746113989637 0.0307804028975754 1.41460768720699 0 0 0.000176959943030976 0.999672346002621 0.99937810218515 0.999850165132458 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3244 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Ala187Val mshA_p.Ala187Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 8244 4835 12602 22633 0.395471553295596 0.388825056295074 0.402147213163804 0.823976991408184 0.819420816820465 0.828464529164069 0.630323419221653 0.621984102219429 0.638604710099516 NA NA NA 0 0 0.000762662376516211 NA NA NA NA NA NA False True 3.06227474603512 2.936683458951 3.19331618220883 0 0 0.000292678908044125 0.823976991408184 0.819420816820465 0.828464529164069 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 5236 3361 8138 17952 0.391505906983699 0.383220794416858 0.399838254514856 0.842302819875193 0.837339770498727 0.847172316025428 0.609049668489007 0.59864113764468 0.619384237546541 NA NA NA 0 0 0.00109695204465264 NA NA NA NA NA NA False True 0 1 1 0 0 1 1 3.43657858501398 3.2658123400863 3.6163167699999 0 0 0.00045318794705226 0.842302819875193 0.837339770498727 0.847172316025428 1051 Not assoc w R 5) Not assoc w R No change yes 1 +Isoniazid mshA p.Ala189fs mshA_p.Ala189fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 7 0 20839 27468 0.000335795836131632 0.000135017659185429 0.000691744589626827 1 0.999865711673152 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 3909 5574 False False Inf 1.89951899263229 Inf 0 0 0.00017700239811062 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3138 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Ala189Val mshA_p.Ala189Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 51.3533466119536 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 62.1009148060541 1 1642.5 4479 False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 0 0 0.000275827900298067 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Ala210Val mshA_p.Ala210Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4078 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3269 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Ala24Val mshA_p.Ala24Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 1 20843 27467 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999963594000291 0.999797175631493 0.999999078280314 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 51.3558084523276 1 2027.5 5574 False False 3.95341361608213 0.31739219148065 207.323829234655 0 0 0.00017696843241753 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3281 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Ala279fs mshA_p.Ala279fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4092 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Ala288Thr mshA_p.Ala288Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4073 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3264 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Ala298Thr mshA_p.Ala298Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3914 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3142 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Ala2Thr mshA_p.Ala2Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Ala323Thr mshA_p.Ala323Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4065 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3256 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Ala337Thr mshA_p.Ala337Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3990 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Ala342Gly mshA_p.Ala342Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Ala342Val mshA_p.Ala342Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3932 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Ala343Val mshA_p.Ala343Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 4146 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 3321 4479 False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 0 0 0.000275827900298067 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Ala347Thr mshA_p.Ala347Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Ala347Val mshA_p.Ala347Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Ala362Asp mshA_p.Ala362Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4011 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3216 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Ala362Val mshA_p.Ala362Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3898 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3128 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Ala364Val mshA_p.Ala364Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4002 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Ala372fs mshA_p.Ala372fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3915 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3143 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Ala373Glu mshA_p.Ala373Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4079 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3270 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Ala380Thr mshA_p.Ala380Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Ala399Thr mshA_p.Ala399Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3939 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3163 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Ala399Val mshA_p.Ala399Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4012 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3217 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Ala401Gly mshA_p.Ala401Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Ala40Gly mshA_p.Ala40Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Ala40Val mshA_p.Ala40Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4023 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3224 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance No change no 1 +Isoniazid mshA p.Ala41Glu mshA_p.Ala41Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4147 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Ala421Glu mshA_p.Ala421Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4120 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3301 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Ala421Val mshA_p.Ala421Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Ala422fs mshA_p.Ala422fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3889 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Ala480Val mshA_p.Ala480Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Ala48Val mshA_p.Ala48Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 7 20846 27461 0 0 0.00017694296670111 0.999745158002038 0.999474999027776 0.999897534357495 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 3940 5574 False False 0 0 0.914121240039481 0 0 0.00017694296670111 0.999745158002038 0.999474999027776 0.999897534357495 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3164 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Ala51Val mshA_p.Ala51Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Ala65Val mshA_p.Ala65Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4121 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3302 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Ala76Ser mshA_p.Ala76Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Ala96Gly mshA_p.Ala96Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Arg138Gly mshA_p.Arg138Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3890 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3122 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Arg166Cys mshA_p.Arg166Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4093 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3282 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Arg168Cys mshA_p.Arg168Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Arg16Cys mshA_p.Arg16Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4013 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3218 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Arg222fs mshA_p.Arg222fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 6 0 20840 27468 0.000287825002398541 0.000105633792978048 0.000626367784710498 1 0.999865711673152 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 3991 5574 False False Inf 1.55167078958407 Inf 0 0 0.000176993905465082 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 6 0 13368 21313 0.000448631673396141 0.000164657143425453 0.000976224581517196 1 0.999826933785262 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 3198 4479 False False 0 0 0 0 0 0 0 Inf 1.87681913692541 Inf 0 0 0.00027591042269331 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Arg222Met mshA_p.Arg222Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4042 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3237 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Arg252Gln mshA_p.Arg252Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4032 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3230 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Arg253Leu mshA_p.Arg253Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Arg26Cys mshA_p.Arg26Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 12 0 12 3 13 20843 27455 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999526722003786 0.99919081619501 0.999747976101462 0.1875 0.0404737339059459 0.456456546231611 0 0 0.264648469397051 0 0 0.24705263800047 0 0 0.474124080412481 0.00183834176591293 84 5574 False False 0.303975878269406 0.0555603888949282 1.1064028896815 0 0 0.00017696843241753 0.999526722003786 0.99919081619501 0.999747976101462 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 1 11 13373 21302 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999483883076056 0.999076712346733 0.999742329032819 0.0833333333333333 0.00210759323186022 0.384796165150944 0 0 0.30849710781876 0 0 0.284914152918154 0 0 0.710785549152857 0.0088919306207434 78 4479 False False 0 0 0 0 0 0 0 0.144810099046246 0.00336819644582784 0.996572767671761 0 0 0.000275807277411719 0.999483883076056 0.999076712346733 0.999742329032819 2 3) Uncertain significance No change no 1 +Isoniazid mshA p.Arg26His mshA_p.Arg26His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Isoniazid mshA p.Arg273Gly mshA_p.Arg273Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3941 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3165 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Arg294Cys mshA_p.Arg294Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Arg314Trp mshA_p.Arg314Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4043 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3238 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Arg324Gln mshA_p.Arg324Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 4122 5574 False False Inf 0.869878292971449 Inf 0 0 0.000176976922618654 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3303 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Arg324Trp mshA_p.Arg324Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Arg413Gln mshA_p.Arg413Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 4 7 20842 27461 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999745158002038 0.999474999027776 0.999897534357495 0.363636363636363 0.109263443819098 0.692095284988322 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.914296620601176 0.0219839272937846 167 5574 False False 0.752902792438345 0.161601315405925 2.9620720115734 0 0 0.000176976922618654 0.999745158002038 0.999474999027776 0.999897534357495 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 62.1009148060541 1 1642.5 4479 False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 0 0 0.000275827900298067 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Arg413Trp mshA_p.Arg413Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 4127 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 3308 4479 False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 0 0 0.000275827900298067 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Arg442Gln mshA_p.Arg442Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3992 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3199 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Arg443His mshA_p.Arg443His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 8 40 20838 27428 0.000383766669864722 0.000165697303700768 0.000756032532322191 0.99854376001165 0.998017536808662 0.998959443307686 0.166666666666666 0.0748108603995931 0.30222241352988 NA NA NA 0 0 0.0880973028788023 NA NA NA NA NA NA False True 0.263249832037623 0.106425908051792 0.570265766696913 0 0 0.000177010891571197 0.99854376001165 0.998017536808662 0.998959443307686 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 8 35 13366 21278 0.000598175564528189 0.000258283997825234 0.00117830226263269 0.998357809787453 0.997716843861875 0.998855896017746 0.186046511627906 0.0839123997755944 0.334014467242413 NA NA NA 0 0 0.100032435572105 NA NA NA NA NA NA False True 0 0 0 0 0 1 0 0.363874222440734 0.145776763477323 0.798747508767489 0 0 0.000275951702410535 0.998357809787453 0.997716843861875 0.998855896017746 NA Not assoc w R Previous WHO guidance 4) Not assoc w R - Interim DOWN from NotAwR to NotAwRI yes Prev. WHO 3 +Isoniazid mshA p.Arg455Gln mshA_p.Arg455Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4128 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3309 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Arg455Leu mshA_p.Arg455Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Arg45Leu mshA_p.Arg45Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3891 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Arg46Trp mshA_p.Arg46Trp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4148 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3322 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Arg5Pro mshA_p.Arg5Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 51.3446878573018 1 2027.5 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 62.0858160113928 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Arg81Cys mshA_p.Arg81Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.31767810026385 0.0167927522337569 103.35711725526 1 1253.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Arg81fs mshA_p.Arg81fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4129 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Asn111Ser mshA_p.Asn111Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1098 2697 19748 24771 0.0526719754389331 0.0496782119222415 0.055791244650408 0.901813018785495 0.898233190340819 0.905307593831312 0.289328063241106 0.274936158974615 0.304045062905189 NA NA NA 0 0 0.00136683642269662 NA NA NA NA NA NA False True 0.510671727391382 0.474457416468132 0.549375647836666 0 0 0.000186780177162725 0.901813018785495 0.898233190340819 0.905307593831312 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 702 2163 12672 19150 0.0524899057873485 0.0487706200483983 0.0564053929724008 0.898512644864636 0.894380580312241 0.902535652082708 0.245026178010471 0.229369267882108 0.261205519171732 NA NA NA 0 0 0.00170399244078473 NA NA NA NA NA NA False True 0 1 1 0 0 1 1 0.4904606922204 0.448472516199428 0.535925042193667 0 0 0.00029106238802367 0.898512644864636 0.894380580312241 0.902535652082708 176 Not assoc w R Not assoc w R 5) Not assoc w R No change yes 1 +Isoniazid mshA p.Asn185Ser mshA_p.Asn185Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Asn185Tyr mshA_p.Asn185Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3948 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3168 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Asn37Asp mshA_p.Asn37Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 51.3446878573018 1 2027.5 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Asn69Ser mshA_p.Asn69Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 9 0 20837 27468 0.000431737503597812 0.000197436276106449 0.000819413341228355 1 0.999865711673152 1 1 0.663732883120057 1 NA NA NA NA NA NA NA NA NA NA 4033 5574 False False Inf 2.60134945111117 Inf 0 0 0.000177019385846931 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 8 0 13366 21313 0.000598175564528189 0.000258283997825234 0.00117830226263269 1 0.999826933785262 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 3231 4479 False False 0 0 0 0 0 0 0 Inf 2.72130996382454 Inf 0 0 0.000275951702410535 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Asp121fs mshA_p.Asp121fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4014 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3219 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Asp121Gly mshA_p.Asp121Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3925 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3153 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Asp124Asn mshA_p.Asp124Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4136 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Isoniazid mshA p.Asp124His mshA_p.Asp124His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Asp167Ala mshA_p.Asp167Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Asp190Asn mshA_p.Asp190Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 1.99597553667858 0.139114336996004 304.5 5574 False False 0 0 1.43785249906968 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 5 13374 21308 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 2.41409066157565 0.305475026346142 461 4479 False False 0 0 0 0 0 0 0 0 0 1.73894646374006 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Asp190fs mshA_p.Asp190fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3982 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Asp192fs mshA_p.Asp192fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4080 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Asp218Ala mshA_p.Asp218Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 42 213 20804 27255 0.00201477501678979 0.00145244658837854 0.00272242536509554 0.992245522062036 0.991136196259996 0.993248726400642 0.164705882352941 0.121358074901867 0.216042354983714 NA NA NA 0 0 0.0171695765109405 NA NA NA NA NA NA False True 0.258326540670672 0.18087044090026 0.361243508643075 0 0 0.000177300155018271 0.992245522062036 0.991136196259996 0.993248726400642 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 27 157 13347 21156 0.00201884253028263 0.0013308384497987 0.00293596074535617 0.99263360390372 0.991392350067822 0.993737482882953 0.146739130434782 0.0989826165539435 0.20627152950506 NA NA NA 0 0 0.0232221646033251 NA NA NA NA NA NA False True 0 0 1 0 0 1 1 0.272592567140973 0.174040018069967 0.412213146157337 0 0 0.000276344476654236 0.99263360390372 0.991392350067822 0.993737482882953 45 Not assoc w R Literature evidence (PMID 32143680) 4) Not assoc w R - Interim DOWN from NotAwR to NotAwRI yes Lit. (PMID 32143680) 3 +Isoniazid mshA p.Asp218Glu mshA_p.Asp218Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01632529799099 0.509386028876591 1135.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3123 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Asp218Gly mshA_p.Asp218Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4066 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3257 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Asp231fs mshA_p.Asp231fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3899 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3129 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Asp236Gly mshA_p.Asp236Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4130 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3310 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Asp245Asn mshA_p.Asp245Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3900 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3130 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Asp245His mshA_p.Asp245His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4084 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3274 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Asp281Gly mshA_p.Asp281Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Asp310Asn mshA_p.Asp310Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4067 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3258 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Asp317Asn mshA_p.Asp317Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Asp383Ala mshA_p.Asp383Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4074 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3265 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Asp400fs mshA_p.Asp400fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4056 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Asp42Tyr mshA_p.Asp42Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3983 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3193 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Asp64Asn mshA_p.Asp64Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4049 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3245 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 2 3) Uncertain significance No change no 1 +Isoniazid mshA p.Gln128* mshA_p.Gln128* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3960 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Gln205Ser mshA_p.Gln205Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4094 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Gln205* mshA_p.Gln205* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Gln363Arg mshA_p.Gln363Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3926 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3154 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Gln363* mshA_p.Gln363* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3901 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3131 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Gln59His mshA_p.Gln59His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Glu118Lys mshA_p.Glu118Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4068 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3259 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Glu144Gly mshA_p.Glu144Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3993 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3200 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Glu209Asp mshA_p.Glu209Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Glu220Asp mshA_p.Glu220Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Glu220* mshA_p.Glu220* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3972 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3186 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Glu22Ala mshA_p.Glu22Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4057 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3251 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Glu22fs mshA_p.Glu22fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3976 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3188 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Glu318Gly mshA_p.Glu318Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4058 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3252 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Glu353* mshA_p.Glu353* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4085 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3275 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Glu447Gln mshA_p.Glu447Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Glu458Gln mshA_p.Glu458Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 5 4 20841 27464 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.999854376001165 0.999627187086024 0.999960320981843 0.555555555555555 0.212008506778868 0.863004337734833 0 0 0.602364635616474 0 0 0.602364635616474 0 0 1.99652637191527 0.139142388186343 355 5574 False False 1.64723381795499 0.354499279020611 8.30243796120459 0 0 0.000176985413634466 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 5 0 13369 21313 0.000373859727830118 0.000121402023062639 0.000872246401868143 1 0.999826933785262 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 3323 4479 False False 0 0 0 0 0 0 0 Inf 1.46057233596553 Inf 0 0 0.000275889787465637 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Glu85Lys mshA_p.Glu85Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4059 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3253 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Gly106Ala mshA_p.Gly106Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 11 0 11 4 18 20842 27450 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999344692005242 0.998964527817385 0.999611578174657 0.181818181818181 0.0518672993124368 0.402845783077871 0 0 0.284914152918154 0 0 0.185301968137852 0 0 0.524836285196487 0.0034973516769603 97 5574 False False 0.292678245849726 0.0720595250968795 0.888697431745747 0 0 0.000176976922618654 0.999344692005242 0.998964527817385 0.999611578174657 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 3 14 13371 21299 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999343123914981 0.998898118907794 0.999640834680135 0.176470588235294 0.0379850680706259 0.434317872844283 0 0 0.369416647552819 0 0 0.231635761650116 0 0 0.933386529111983 0.0270122295690491 116 4479 False False 0 0 0 0 0 0 0 0.341341068623994 0.0628905215833431 1.22336182693063 0 0 0.000275848526268708 0.999343123914981 0.998898118907794 0.999640834680135 5 3) Uncertain significance No change no 1 +Isoniazid mshA p.Gly106Arg mshA_p.Gly106Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 2 7 20844 27461 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999745158002038 0.999474999027776 0.999897534357495 0.222222222222222 0.0281449734778982 0.600093573716312 0 0 0.707598226178713 0 0 0.409616397225003 0 0 3.18849473106986 0.264069191039105 433 5574 False False 0.376415275379005 0.0381509889597215 1.97729867984898 0 0 0.000176959943030976 0.999745158002038 0.999474999027776 0.999897534357495 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 7 13373 21306 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.99967156195749 0.999323409938814 0.999867941002665 0.125 0.0031597235312519 0.526509670875206 0 0 0.707598226178713 0 0 0.409616397225003 0 0 3.85608284137978 0.289249091833513 280.5 4479 False False 0 0 0 0 0 0 0 0.227601457093717 0.00505385949080816 1.77192833352817 0 0 0.000275807277411719 0.99967156195749 0.999323409938814 0.999867941002665 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Gly106Val mshA_p.Gly106Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3954 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3169 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Gly11Arg mshA_p.Gly11Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 1 6 20845 27462 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999781564001747 0.999524617886493 0.999919833755107 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.602364635616474 0 0 0.4592581264399 0 0 1.99599858618782 0.139115509937566 310.5 5574 False False 0.219573039098105 0.00477770915407814 1.81014820057657 0 0 0.000176951454458875 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 5 13373 21308 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999765401398207 0.999452610763328 0.999923822225278 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.707598226178713 0 0 0.521823750104981 0 0 3.85644483335007 0.289264358093288 303 4479 False False 0 0 0 0 0 0 0 0.318671950945935 0.00674139558547252 2.84834809554519 0 0 0.000275807277411719 0.999765401398207 0.999452610763328 0.999923822225278 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Gly135Trp mshA_p.Gly135Trp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3902 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3132 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Gly193Arg mshA_p.Gly193Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4015 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3220 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Gly21fs mshA_p.Gly21fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4149 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Gly229fs mshA_p.Gly229fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4095 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3283 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Gly260Arg mshA_p.Gly260Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 3892 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3124 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Gly292Ala mshA_p.Gly292Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3927 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3155 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Gly292Arg mshA_p.Gly292Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 21 0 21 22 28 20824 27440 0.00105535834212798 0.000661501919043129 0.00159739179996395 0.998980632008154 0.998527063823414 0.999322533833553 0.44 0.299907220927543 0.587455877058326 0 0 0.161097615219079 0 0 0.123436118500263 0 0 0.253088509185573 7.71503542154981e-06 42 5574 True False 1.03534383403764 0.564323535250718 1.87697911977997 0 0 0.000177129885664148 0.998980632008154 0.998527063823414 0.999322533833553 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 21 0 21 18 28 13356 21285 0.00134589502018842 0.000797851614369596 0.00212626349435784 0.998686247829963 0.99810181776224 0.999126849229516 0.391304347826087 0.250879411560762 0.546258620587539 0 0 0.161097615219079 0 0 0.123436118500263 0 0 0.306128788639782 4.8207681083122e-05 33 4479 True False 0 0 0 0 0 0 0 1.02449942241047 0.53346839799718 1.91944539753179 0 0 0.000276158286414525 0.998686247829963 0.99810181776224 0.999126849229516 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Gly292Trp mshA_p.Gly292Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4086 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3276 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Gly29Ala mshA_p.Gly29Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 1 20843 27467 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999963594000291 0.999797175631493 0.999999078280314 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 51.3558084523276 1 2027.5 5574 False False 3.95341361608213 0.31739219148065 207.323829234655 0 0 0.00017696843241753 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 62.1009148060541 1 1642.5 4479 False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 0 0 0.000275827900298067 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Gly29Asp mshA_p.Gly29Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4003 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3208 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Gly305Asp mshA_p.Gly305Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3903 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Gly311* mshA_p.Gly311* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4016 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Gly320Ser mshA_p.Gly320Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Gly32Glu mshA_p.Gly32Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 7.01547785354097 0.509377906736075 843 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 8.48455543336434 0.526168130935474 674.5 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 2 3) Uncertain significance No change no 1 +Isoniazid mshA p.Gly375Val mshA_p.Gly375Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4004 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3209 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Gly384Arg mshA_p.Gly384Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3916 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3144 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Gly384Val mshA_p.Gly384Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Gly392Glu mshA_p.Gly392Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Gly396Ala mshA_p.Gly396Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Gly396Ser mshA_p.Gly396Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3928 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3156 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Gly3Val mshA_p.Gly3Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4137 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3314 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Gly411Arg mshA_p.Gly411Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Gly446Ser mshA_p.Gly446Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 6 20846 27462 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 1.43779998918648 0.0743349556518805 235.5 5574 False False 0 0 1.11900921779861 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 13374 21308 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.73894646374006 0.163960020972012 248.5 4479 False False 0 0 0 0 0 0 0 0 0 1.73894646374006 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Gly456Ala mshA_p.Gly456Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3994 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3201 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Gly456fs mshA_p.Gly456fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3949 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Gly477Arg mshA_p.Gly477Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 7.01547785354097 0.509377906736075 843 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3179 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Gly477del mshA_p.Gly477del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Gly479Asp mshA_p.Gly479Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Gly479Ser mshA_p.Gly479Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Gly67Ala mshA_p.Gly67Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4096 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Gly67Arg mshA_p.Gly67Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3929 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3157 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Gly83Arg mshA_p.Gly83Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance No change no 1 +Isoniazid mshA p.His143Asp mshA_p.His143Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.His143Gln mshA_p.His143Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.His152Arg mshA_p.His152Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3984 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3194 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.His154fs mshA_p.His154fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4050 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3246 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.His175fs mshA_p.His175fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4005 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3210 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.His175Pro mshA_p.His175Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4024 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3225 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.His228Asn mshA_p.His228Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.His228Pro mshA_p.His228Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3917 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3145 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.His228Tyr mshA_p.His228Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4097 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3284 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.His239fs mshA_p.His239fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4150 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.His404Asn mshA_p.His404Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.His404Gln mshA_p.His404Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4151 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3324 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.His471Arg mshA_p.His471Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 8 20846 27460 0 0 0.00017694296670111 0.99970875200233 0.999426206431739 0.999874251669172 0 0 0.369416647552819 0 0 0.409616397225003 0 0 0.369416647552819 0 0 0.914087967691346 0.0219732170480025 152 5574 False False 0 0 0.771808536885009 0 0 0.00017694296670111 0.99970875200233 0.999426206431739 0.999874251669172 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 6 13374 21307 0 0 0.000275786657608973 0.999718481677849 0.999387354605726 0.999896680954833 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 1.73886488920615 0.163959928472831 238.5 4479 False False 0 0 0 0 0 0 0 0 0 1.35335561005417 0 0 0.000275786657608973 0.999718481677849 0.999387354605726 0.999896680954833 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.His471Pro mshA_p.His471Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4006 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3211 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.His53Arg mshA_p.His53Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3967 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3180 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.His53fs mshA_p.His53fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3918 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3146 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.His53Pro mshA_p.His53Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3910 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3139 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.His6Arg mshA_p.His6Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Ile296Ser mshA_p.Ile296Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Ile402Thr mshA_p.Ile402Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4025 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Ile445Thr mshA_p.Ile445Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3995 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3202 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Ile460Thr mshA_p.Ile460Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Ile84fs mshA_p.Ile84fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3974 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3187 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Ile84Leu mshA_p.Ile84Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3973 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Leu125Met mshA_p.Leu125Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Leu12Ser mshA_p.Leu12Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Leu12Trp mshA_p.Leu12Trp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3930 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Leu12Val mshA_p.Leu12Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Leu137Pro mshA_p.Leu137Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 6 0 20840 27468 0.000287825002398541 0.000105633792978048 0.000626367784710498 1 0.999865711673152 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 4087 5574 False False Inf 1.55167078958407 Inf 0 0 0.000176993905465082 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Leu157fs mshA_p.Leu157fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4138 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Leu188Val mshA_p.Leu188Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 26 0 26 10 28 20836 27440 0.000479708337330902 0.000230061997553563 0.000882023176671562 0.998980632008154 0.998527063823414 0.999322533833553 0.263157894736842 0.134033723024973 0.431008243702239 0 0 0.132274604497754 0 0 0.123436118500263 0 0 0.200811068152819 6.11260714610292e-07 30 5574 True False 0.470339796506047 0.203781965085038 0.997869095573482 0 0 0.000177027880937939 0.998980632008154 0.998527063823414 0.999322533833553 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 23 0 23 6 24 13368 21289 0.000448631673396141 0.000164657143425453 0.000976224581517196 0.998873926711396 0.998324952535764 0.99927837451873 0.2 0.0771355120010656 0.385666510996607 0 0 0.148185128915224 0 0 0.142473597722525 0 0 0.277112437861468 1.59750110100744e-05 30 4479 True False 0 0 0 0 0 0 0 0.398133602633153 0.133093030000132 1.00012457150483 0 0 0.00027591042269331 0.998873926711396 0.998324952535764 0.99927837451873 2 3) Uncertain significance No change no 1 +Isoniazid mshA p.Leu198Arg mshA_p.Leu198Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3961 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Leu284Pro mshA_p.Leu284Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3933 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3158 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Leu306Arg mshA_p.Leu306Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.43785249906968 0.0743380732312645 251 5574 False False 0 0 1.43785249906968 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Isoniazid mshA p.Leu377fs mshA_p.Leu377fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4026 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3226 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Leu377His mshA_p.Leu377His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4034 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Leu389Pro mshA_p.Leu389Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 18 0 20828 27468 0.000863475007195625 0.000511827761943967 0.00136432078973001 1 0.999865711673152 1 1 0.814698031862147 1 NA NA NA NA NA NA NA NA NA NA 3919 5574 False False Inf 5.79721409304801 Inf 0 0 0.000177095871029953 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 17 0 13357 21313 0.0012711230746224 0.000740644897312986 0.00203441363276193 1 0.999826933785262 1 1 0.804935677030906 1 NA NA NA NA NA NA NA NA NA NA 3147 4479 False False 0 0 0 0 0 0 0 Inf 6.58228232638527 Inf 0 0 0.000276137614096336 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Leu405Arg mshA_p.Leu405Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3996 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Leu406Ala mshA_p.Leu406Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4098 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3285 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Leu408Ser mshA_p.Leu408Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Leu463Arg mshA_p.Leu463Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4139 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3315 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Leu73fs mshA_p.Leu73fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3931 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Leu77Arg mshA_p.Leu77Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Leu79Pro mshA_p.Leu79Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3997 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3203 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Lys184Thr mshA_p.Lys184Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4110 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3295 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Lys278Glu mshA_p.Lys278Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3920 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3148 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Met417Val mshA_p.Met417Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4111 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Met72Thr mshA_p.Met72Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Phe117fs mshA_p.Phe117fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4035 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3232 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Phe327Ile mshA_p.Phe327Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Pro105Ser mshA_p.Pro105Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3893 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Pro105Thr mshA_p.Pro105Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4051 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3247 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Pro126Ser mshA_p.Pro126Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3998 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3204 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Pro194Thr mshA_p.Pro194Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Pro197fs mshA_p.Pro197fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 7 0 20839 27468 0.000335795836131632 0.000135017659185429 0.000691744589626827 1 0.999865711673152 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 4060 5574 False False Inf 1.89951899263229 Inf 0 0 0.00017700239811062 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3254 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Pro249Ala mshA_p.Pro249Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3985 5574 False False Inf 0.869878292971449 Inf 0 0 0.000176976922618654 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 13370 21313 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 1 0.999826933785262 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3195 4479 False False 0 0 0 0 0 0 0 Inf 1.05210128917758 Inf 0 0 0.000275869155324334 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Pro249fs mshA_p.Pro249fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3962 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Pro249Leu mshA_p.Pro249Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.43785249906968 0.0743380732312645 251 5574 False False 0 0 1.43785249906968 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Pro249Ser mshA_p.Pro249Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4099 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Pro280His mshA_p.Pro280His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4152 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Pro30Leu mshA_p.Pro30Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 1 6 20845 27462 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999781564001747 0.999524617886493 0.999919833755107 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.11906289991934 0.040214073694581 205 5574 False False 0.219573039098105 0.00477770915407814 1.81014820057657 0 0 0.000176951454458875 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 1 6 13373 21307 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999718481677849 0.999387354605726 0.999896680954833 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.35345678111722 0.0884835334370246 175 4479 False False 0 0 0 0 0 0 0 0.265547496198808 0.00577686092206708 2.18912593855065 0 0 0.000275807277411719 0.999718481677849 0.999387354605726 0.999896680954833 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Pro329Ser mshA_p.Pro329Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4081 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3271 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Pro33Ser mshA_p.Pro33Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Pro349Ser mshA_p.Pro349Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Pro44Leu mshA_p.Pro44Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Pro469Leu mshA_p.Pro469Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3986 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Pro474Leu mshA_p.Pro474Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4112 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3296 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Pro474Ser mshA_p.Pro474Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Pro56Thr mshA_p.Pro56Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3921 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Pro99Leu mshA_p.Pro99Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Ser10Leu mshA_p.Ser10Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18880616510555 0.264079043314886 541.5 5574 False False 0.439194051331254 0.00837049629364692 5.4704842261679 0 0 0.000176951454458875 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 3 13373 21310 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999859240838924 0.999588697652472 0.999970971136275 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85680682534852 0.289279625558287 389.5 4479 False False 0 0 0 0 0 0 0 0.531169769934445 0.010122018243966 6.61631049307563 0 0 0.000275807277411719 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Ser226Ala mshA_p.Ser226Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Ser302fs mshA_p.Ser302fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4061 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Ser308Leu mshA_p.Ser308Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 51.349017027227 1 2027.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3133 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Ser308Thr mshA_p.Ser308Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Ser31fs mshA_p.Ser31fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4113 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3297 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Ser31Phe mshA_p.Ser31Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Ser352His mshA_p.Ser352His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3950 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Ser354Ala mshA_p.Ser354Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3951 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Ser429* mshA_p.Ser429* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4100 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Ser440fs mshA_p.Ser440fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3955 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Ser461* mshA_p.Ser461* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Ser55* mshA_p.Ser55* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4044 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Ser95Pro mshA_p.Ser95Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3956 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3170 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Ter481ext*? mshA_p.Ter481ext*? 2 stop_lost (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4052 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Thr176fs mshA_p.Thr176fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4027 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Thr179Arg mshA_p.Thr179Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4153 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3325 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Thr334Ala mshA_p.Thr334Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 9 0 9 1 16 20845 27452 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.99941750400466 0.999054234895718 0.999667017718464 0.0588235294117647 0.00148817439126663 0.28688939666722 0 0 0.336267116879942 0 0 0.205907214207822 0 0 0.667310607337887 0.0128630313919217 144 5574 False False 0.0823099064523866 0.00196698357180464 0.529947121754166 0 0 0.000176951454458875 0.99941750400466 0.999054234895718 0.999667017718464 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 1 12 13373 21301 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999436963355698 0.999016695060306 0.999709037985722 0.0769230769230769 0.00194562849734675 0.360297435267877 0 0 0.521823750104981 0 0 0.264648469397051 0 0 1.73850539918319 0.163959531705997 232 4479 False False 0 0 0 0 0 0 0 0.13273635933099 0.00310903086841441 0.897376525284345 0 0 0.000275807277411719 0.999436963355698 0.999016695060306 0.999709037985722 3 3) Uncertain significance No change no 1 +Isoniazid mshA p.Thr338Ala mshA_p.Thr338Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4062 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Thr367Ala mshA_p.Thr367Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3957 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3171 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Thr386fs mshA_p.Thr386fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3958 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3172 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Thr388Ala mshA_p.Thr388Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4114 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Thr473Ala mshA_p.Thr473Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4069 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3260 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Thr93fs mshA_p.Thr93fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4101 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3286 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Trp169Cys mshA_p.Trp169Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3952 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Trp430* mshA_p.Trp430* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3959 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3173 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Trp472* mshA_p.Trp472* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Tyr123* mshA_p.Tyr123* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4045 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3239 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Tyr155Ser mshA_p.Tyr155Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4154 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3326 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Tyr441Ser mshA_p.Tyr441Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4115 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3298 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Val100Leu mshA_p.Val100Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Val100Met mshA_p.Val100Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Val101Leu mshA_p.Val101Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Val103_Ala104insGly mshA_p.Val103_Ala104insGly 2 inframe_insertion (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4070 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3261 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Val107Gly mshA_p.Val107Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4017 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3221 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Val112Leu mshA_p.Val112Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Val113Leu mshA_p.Val113Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Val113Met mshA_p.Val113Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Val151Met mshA_p.Val151Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Val161Leu mshA_p.Val161Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3942 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3166 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Val201Leu mshA_p.Val201Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Val224_Ser226del mshA_p.Val224_Ser226del 2 inframe_deletion (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4140 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Val238fs mshA_p.Val238fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3963 5574 False False Inf 0.869878292971449 Inf 0 0 0.000176976922618654 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3175 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Val271Ile mshA_p.Val271Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4018 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3222 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Val271Leu mshA_p.Val271Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3911 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Val283Met mshA_p.Val283Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Val293Trp mshA_p.Val293Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3894 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Val325Met mshA_p.Val325Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 4 1 20842 27467 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999963594000291 0.999797175631493 0.999999078280314 0.8 0.28358206388191 0.994949236620532 0 0 0.975 0 0 0.975 0 0 51.3582705287504 1 2027.5 5574 False False 5.27147106803569 0.521589398427432 259.279173455301 0 0 0.000176976922618654 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 1 13371 21312 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999953080279641 0.999738608085756 0.999998812096234 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 62.1055547471297 1 1642.5 4479 False False 0 0 0 0 0 0 0 4.78169172088849 0.383875689805931 250.696170545132 0 0 0.000275848526268708 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Val346Ala mshA_p.Val346Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Val360Ala mshA_p.Val360Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4131 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3311 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Val369Met mshA_p.Val369Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3934 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Val390Ala mshA_p.Val390Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 12 0 20834 27468 0.000575650004797083 0.000297481006307132 0.00100532857413147 1 0.999865711673152 1 1 0.735351530602948 1 NA NA NA NA NA NA NA NA NA NA 4082 5574 False False Inf 3.66300284077067 Inf 0 0 0.000177044873566246 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 5 0 13369 21313 0.000373859727830118 0.000121402023062639 0.000872246401868143 1 0.999826933785262 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 3272 4479 False False 0 0 0 0 0 0 0 Inf 1.46057233596553 Inf 0 0 0.000275889787465637 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Val416Met mshA_p.Val416Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 51.3446878573018 1 2027.5 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Val459Met mshA_p.Val459Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3987 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3196 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Val464Ala mshA_p.Val464Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4116 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3299 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Val464Leu mshA_p.Val464Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Val466Ala mshA_p.Val466Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid mshA p.Val478Ala mshA_p.Val478Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4046 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3240 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Val4Met mshA_p.Val4Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 3 9 20843 27459 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999672346002621 0.99937810218515 0.999850165132458 0.25 0.0548606445279927 0.571858461878189 0 0 0.521823750104981 0 0 0.336267116879942 0 0 1.43785001820697 0.074337924711882 240 5574 False False 0.439140238929136 0.0764596530706342 1.75996892947283 0 0 0.00017696843241753 0.999672346002621 0.99937810218515 0.999850165132458 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 3 8 13371 21305 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999624642237132 0.999260530264256 0.999837933676441 0.272727272727272 0.0602177341729066 0.609742559572421 0 0 0.521823750104981 0 0 0.369416647552819 0 0 1.73909174407345 0.163960181593021 262 4479 False False 0 0 0 0 0 0 0 0.597515144716176 0.102061600869156 2.49011680409225 0 0 0.000275848526268708 0.999624642237132 0.999260530264256 0.999837933676441 1 3) Uncertain significance No change no 1 +Isoniazid mshA p.Val70Ile mshA_p.Val70Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3977 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3189 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid mshA p.Val86fs mshA_p.Val86fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3912 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3140 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh c.1011C>T ndh_c.1011C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.1017G>A ndh_c.1017G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.1020G>C ndh_c.1020G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.1029C>T ndh_c.1029C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.102G>A ndh_c.102G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.1032C>G ndh_c.1032C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 13 0 20833 27468 0.000623620838530173 0.000332092285535748 0.00106617452923529 1 0.999865711673152 1 1 0.752947361999529 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 4.01743988819503 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 4 0 13370 21313 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 1 0.999826933785262 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.05210128917758 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.1044G>A ndh_c.1044G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.1080G>A ndh_c.1080G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.108C>T ndh_c.108C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.-11_-7delAGCAG ndh_c.-11_-7delAGCAG 2 upstream_gene_variant 2103048 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh c.1101G>A ndh_c.1101G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.1122G>A ndh_c.1122G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 28 45 20818 27423 0.00134318334452652 0.000892715366584833 0.00194069331308385 0.998361730013106 0.997808473060249 0.998804791378681 0.383561643835616 0.27208638354562 0.504793771269344 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.819636852723604 0.49219270495865 1.34332561861849 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 28 44 13346 21269 0.00209361447584866 0.00139162853566266 0.00302444516059537 0.997935532304227 0.997229528416783 0.99849956619829 0.388888888888888 0.276154685847455 0.51106306377231 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 0 1 0 0 0 1 1.0141479231094 0.607677305049188 1.66677100318416 NA NA NA NA NA NA 5 Literature evidence (PMID 32143680) 4) Not assoc w R - Interim Now listed Silent mutation no Lit. (PMID 32143680) 0 +Isoniazid ndh c.1125G>A ndh_c.1125G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.1128T>C ndh_c.1128T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.1140C>G ndh_c.1140C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.1152C>A ndh_c.1152C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.18865318395302 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.85651838973546 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.1152C>G ndh_c.1152C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 3 20844 27465 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999890782000873 0.99968085216583 0.999977476056514 0.4 0.0527449505263169 0.853367200365326 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.878430243715217 0.0733354884838472 7.66963698207431 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.1164C>T ndh_c.1164C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.1194G>A ndh_c.1194G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.1195C>T ndh_c.1195C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 10 0 20836 27468 0.000479708337330902 0.000230061997553563 0.000882023176671562 1 0.999865711673152 1 1 0.691502892181239 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 2.95450432812812 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 7 0 13367 21313 0.000523403618962165 0.000210460468745924 0.00107811225334149 1 0.999826933785262 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 2.29755378883993 Inf NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.1203G>A ndh_c.1203G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.439194051331254 0.00837049629364692 5.4704842261679 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.1206G>A ndh_c.1206G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.1206G>C ndh_c.1206G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.1206G>T ndh_c.1206G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.120C>A ndh_c.120C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.1210C>T ndh_c.1210C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.1212G>A ndh_c.1212G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 80 0 20766 27468 0.00383766669864722 0.00304416848759615 0.00477406540290361 1 0.999865711673152 1 1 0.954935964932307 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 28.0425773476356 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 17 0 13357 21313 0.0012711230746224 0.000740644897312986 0.00203441363276193 1 0.999826933785262 1 1 0.804935677030906 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 6.58228232638527 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.1218G>T ndh_c.1218G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.1236C>T ndh_c.1236C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.1248G>A ndh_c.1248G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.124C>T ndh_c.124C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.247471899512553 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.1257G>A ndh_c.1257G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 5 20845 27463 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999817970001456 0.999575254267103 0.999940892797913 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.263497241544735 0.00557522895465965 2.35509564487831 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.41420404242617 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.1266C>G ndh_c.1266C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.99604811372315 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.41420404242617 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.1272T>G ndh_c.1272T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.-12G>A ndh_c.-12G>A 2 upstream_gene_variant 2103054 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid ndh c.1302G>A ndh_c.1302G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.1314G>A ndh_c.1314G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.1320G>A ndh_c.1320G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.1320G>C ndh_c.1320G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 4 20845 27464 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999854376001165 0.999627187086024 0.999960320981843 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.329383545214679 0.00669260119676484 3.32889360843958 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.1332G>A ndh_c.1332G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.1342C>T ndh_c.1342C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.1344G>T ndh_c.1344G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 7 20845 27461 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999745158002038 0.999474999027776 0.999897534357495 0.125 0.0031597235312519 0.526509670875206 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.188198608779083 0.00417990056987037 1.46513319151887 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 7 13373 21306 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.99967156195749 0.999323409938814 0.999867941002665 0.125 0.0031597235312519 0.526509670875206 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.227601457093717 0.00505385949080816 1.77192833352817 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.135C>T ndh_c.135C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.1374C>T ndh_c.1374C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.1380G>A ndh_c.1380G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.1386C>T ndh_c.1386C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.138C>T ndh_c.138C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.1392G>A ndh_c.1392G>A 2 stop_retained_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.18865318395302 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.85651838973546 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.147C>T ndh_c.147C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.148C>T ndh_c.148C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.156G>A ndh_c.156G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.159G>A ndh_c.159G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 1 20842 27467 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999963594000291 0.999797175631493 0.999999078280314 0.8 0.28358206388191 0.994949236620532 NA NA NA NA NA NA NA NA NA NA NA NA False False 5.27147106803569 0.521589398427432 259.279173455301 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.165G>A ndh_c.165G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.168C>T ndh_c.168C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.-16T>C ndh_c.-16T>C 2 upstream_gene_variant 2103058 0 0 0 0 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4724 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3795 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid ndh c.-17G>A ndh_c.-17G>A 2 upstream_gene_variant 2103059 1 5 0 5 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.43785249906968 0.0743380732312645 251 5574 False False 0 0 1.43785249906968 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 13374 21308 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.73894646374006 0.163960020972012 248.5 4479 False False 0 0 0 0 0 0 0 0 0 1.73894646374006 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 1 3) Uncertain significance No change no 1 +Isoniazid ndh c.180C>T ndh_c.180C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.183G>C ndh_c.183G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.186T>C ndh_c.186T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.-18C>T ndh_c.-18C>T 2 upstream_gene_variant 2103060 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4581 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh c.-1C>G ndh_c.-1C>G 2 upstream_gene_variant 2103043 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4793 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh c.-1C>T ndh_c.-1C>T 2 upstream_gene_variant 2103043 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4631 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3729 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh c.204C>A ndh_c.204C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.213G>A ndh_c.213G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.21C>G ndh_c.21C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 21 20843 27447 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999235474006116 0.998831576963824 0.999526686034611 0.125 0.0265593149862489 0.323611358188833 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.188120711989636 0.0359255331223503 0.630172266058811 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 20 13371 21293 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.99906160559283 0.998551096167295 0.999426713067202 0.130434782608695 0.0277515074227932 0.335889137537121 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.238871438187121 0.0454513717866924 0.805699288313031 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.228G>A ndh_c.228G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.-23_-22insG ndh_c.-23_-22insG 2 upstream_gene_variant 2103064 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4725 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3796 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh c.-23G>A ndh_c.-23G>A 2 upstream_gene_variant 2103065 0 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4626 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3727 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid ndh c.249G>A ndh_c.249G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.-24T>C ndh_c.-24T>C 2 upstream_gene_variant 2103066 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid ndh c.252A>C ndh_c.252A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 11 20844 27457 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999599534003203 0.9992835689522 0.999800072407065 0.153846153846153 0.0192066719825284 0.454471055676557 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.239502102196402 0.02578903914769 1.09755702800922 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.253C>T ndh_c.253C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.439194051331254 0.00837049629364692 5.4704842261679 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.85651838973546 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.255G>A ndh_c.255G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.267C>T ndh_c.267C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.43785249906968 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.41420404242617 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.270C>G ndh_c.270C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.273C>T ndh_c.273C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.27G>A ndh_c.27G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 2 20842 27466 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999927188000582 0.999737003036386 0.999991182007438 0.666666666666666 0.222778095503512 0.956728131707258 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.63563957393724 0.377684835565828 29.1411399702847 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 4 2 13370 21311 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 0.999906160559283 0.999661061221376 0.999988635406343 0.666666666666666 0.222778095503512 0.956728131707258 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.18788332086761 0.456775580099959 35.246992707007 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.282G>A ndh_c.282G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.658815063564403 0.011171855707321 12.6567401482543 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.285C>A ndh_c.285C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.288G>A ndh_c.288G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.288G>T ndh_c.288G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.-28G>A ndh_c.-28G>A 2 upstream_gene_variant 2103070 1 2 0 2 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 7.01573328293188 0.509380354735251 864 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.48495357236853 0.526173219289417 690 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh c.291G>A ndh_c.291G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.303G>A ndh_c.303G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.312C>T ndh_c.312C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.315T>G ndh_c.315T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.-31A>G ndh_c.-31A>G 2 upstream_gene_variant 2103073 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4603 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3708 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh c.321C>G ndh_c.321C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.324C>T ndh_c.324C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.18865318395302 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.33A>C ndh_c.33A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.247471899512553 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.33A>G ndh_c.33A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.-34C>T ndh_c.-34C>T 2 upstream_gene_variant 2103076 1 3 0 3 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18880616510555 0.264079043314886 541.5 5574 False False 0.439194051331254 0.00837049629364692 5.4704842261679 0 0 0.000176951454458875 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48598624162872 0.526186417038858 925 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid ndh c.372T>C ndh_c.372T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.247471899512553 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.387C>T ndh_c.387C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 6 20844 27462 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999781564001747 0.999524617886493 0.999919833755107 0.25 0.0318540262499442 0.650855794412824 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.439167146421032 0.0433460282809438 2.45619176778693 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 5 13373 21308 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999765401398207 0.999452610763328 0.999923822225278 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.318671950945935 0.00674139558547252 2.84834809554519 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.408C>A ndh_c.408C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.-40A>G ndh_c.-40A>G 2 upstream_gene_variant 2103082 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh c.411C>T ndh_c.411C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.420C>T ndh_c.420C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.426C>T ndh_c.426C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.429C>T ndh_c.429C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.658815063564403 0.011171855707321 12.6567401482543 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.-43_-42insCGTAGTAGCTAAC ndh_c.-43_-42insCGTAGTAGCTAAC 2 upstream_gene_variant 2103084 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh c.450C>A ndh_c.450C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.-45A>G ndh_c.-45A>G 2 upstream_gene_variant 2103087 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid ndh c.46C>A ndh_c.46C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.-46T>G ndh_c.-46T>G 2 upstream_gene_variant 2103088 1 52 2 50 7 56 20839 27412 0.000335795836131632 0.000135017659185429 0.000691744589626827 0.99796126401631 0.997353337776529 0.99845960453209 0.111111111111111 0.0458566237168707 0.215624248702528 0.0384615384615384 0.00469228900927086 0.132128407276802 0.0344827586206896 0.00420364723986767 0.119077310880392 0.052616728249916 0.0062080078007014 0.200315572408192 2.45691935350597e-10 16 5574 True False 0.164427275780987 0.063215906322483 0.361704091333861 9.59646849959215e-05 1.16219798536933e-05 0.000346613988581222 0.99796126401631 0.997353337776529 0.99845960453209 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 52 2 50 7 56 13367 21257 0.000523403618962165 0.000210460468745924 0.00107811225334149 0.997372495659926 0.996589305975568 0.998014619674392 0.111111111111111 0.0458566237168707 0.215624248702528 0.0384615384615384 0.00469228900927086 0.132128407276802 0.0344827586206896 0.00420364723986767 0.119077310880392 0.0636103837809531 0.00748020825705506 0.242188924787181 9.00325414079792e-09 12 4479 True False 0 0 0 0 0 0 0 0.198782449315478 0.0764002655143505 0.437357973679555 0.000149599820480215 1.81177457887837e-05 0.000540300402371359 0.997372495659926 0.996589305975568 0.998014619674392 1 3) Uncertain significance No change no 1 +Isoniazid ndh c.474C>T ndh_c.474C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.498G>A ndh_c.498G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 7 20846 27461 0 0 0.00017694296670111 0.999745158002038 0.999474999027776 0.999897534357495 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.914121240039481 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.41420404242617 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.522C>T ndh_c.522C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.525T>C ndh_c.525T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.99604811372315 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.41420404242617 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.528C>A ndh_c.528C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.531G>A ndh_c.531G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.537C>T ndh_c.537C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 19 20846 27449 0 0 0.00017694296670111 0.999308286005533 0.998920012739518 0.999583493240977 0 0 0.176466911806965 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.282203610593972 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 19 13374 21294 0 0 0.000275786657608973 0.999108525313189 0.998608200368116 0.999463191365845 0 0 0.176466911806965 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.341256884077743 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.540C>T ndh_c.540C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.-54G>T ndh_c.-54G>T 2 upstream_gene_variant 2103096 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4711 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh c.-55C>A ndh_c.-55C>A 2 upstream_gene_variant 2103097 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh c.-55C>G ndh_c.-55C>G 2 upstream_gene_variant 2103097 NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4674 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3762 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh c.561A>C ndh_c.561A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.564G>A ndh_c.564G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.570C>T ndh_c.570C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.576G>A ndh_c.576G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.247471899512553 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.-57A>G ndh_c.-57A>G 2 upstream_gene_variant 2103099 NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4751 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3815 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh c.-5G>A ndh_c.-5G>A 2 upstream_gene_variant 2103047 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh c.606G>C ndh_c.606G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.615C>T ndh_c.615C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.633G>A ndh_c.633G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.639G>A ndh_c.639G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.-63T>C ndh_c.-63T>C 2 upstream_gene_variant 2103105 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4622 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3724 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh c.642T>C ndh_c.642T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.654G>A ndh_c.654G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.-65G>A ndh_c.-65G>A 2 upstream_gene_variant 2103107 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4611 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid ndh c.660G>A ndh_c.660G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.661C>T ndh_c.661C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.663G>A ndh_c.663G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.247471899512553 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.669G>A ndh_c.669G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.675C>T ndh_c.675C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.678A>C ndh_c.678A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.687T>G ndh_c.687T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.-70G>T ndh_c.-70G>T 2 upstream_gene_variant 2103112 NA 0 0 0 27 45 20819 27423 0.00129521251079343 0.000853721301750774 0.00188391092655412 0.998361730013106 0.997808473060249 0.998804791378681 0.375 0.263610947601648 0.497014070628716 NA NA NA 0 0 0.078705100406843 NA NA NA NA NA NA False True 0.790326144387338 0.471364482648885 1.30207431204898 0 0 0.000177172422335812 0.998361730013106 0.997808473060249 0.998804791378681 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 27 44 13347 21269 0.00201884253028263 0.0013308384497987 0.00293596074535617 0.997935532304227 0.997229528416783 0.99849956619829 0.380281690140845 0.267603559493753 0.50327929996552 NA NA NA 0 0 0.0804199397635758 NA NA NA NA NA NA False True 0 0 1 0 0 1 1 0.977855084901612 0.581926891290553 1.61547585277929 0 0 0.000276344476654236 0.997935532304227 0.997229528416783 0.99849956619829 5 Not assoc w RI Literature evidence (PMID 32143680) 4) Not assoc w R - Interim No change yes Lit. (PMID 32143680) 1 +Isoniazid ndh c.741G>T ndh_c.741G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.753C>T ndh_c.753C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.-75G>A ndh_c.-75G>A 2 upstream_gene_variant 2103117 NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4652 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3746 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh c.-75G>C ndh_c.-75G>C 2 upstream_gene_variant 2103117 NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4689 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3774 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh c.765C>T ndh_c.765C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.768C>T ndh_c.768C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.-76T>C ndh_c.-76T>C 2 upstream_gene_variant 2103118 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh c.777C>T ndh_c.777C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.786C>T ndh_c.786C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.810G>A ndh_c.810G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.822G>A ndh_c.822G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.99604811372315 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.825C>T ndh_c.825C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.834C>T ndh_c.834C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.247471899512553 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.858C>T ndh_c.858C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.864C>T ndh_c.864C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.87G>A ndh_c.87G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.87G>T ndh_c.87G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.894C>T ndh_c.894C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.897G>A ndh_c.897G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.903C>T ndh_c.903C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.43785249906968 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.906G>A ndh_c.906G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.906G>C ndh_c.906G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.-90T>C ndh_c.-90T>C 2 upstream_gene_variant 2103132 NA 0 0 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 4653 5574 False False Inf 0.869878292971449 Inf 0 0 0.000176976922618654 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3747 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh c.918G>T ndh_c.918G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.-91G>A ndh_c.-91G>A 2 upstream_gene_variant 2103133 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh c.924C>T ndh_c.924C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.936C>T ndh_c.936C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.945G>A ndh_c.945G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.869878292971449 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.948C>T ndh_c.948C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 10 20845 27458 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999635940002912 0.999330582956894 0.999825405716755 0.0909090909090909 0.00229897221381426 0.412779916988382 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.131724634204845 0.00303942055735959 0.926075505001071 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 9 13373 21304 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999577722516773 0.999198537836033 0.999806890245066 0.1 0.00252857854446178 0.445016117028195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.177006738286929 0.00404223590282617 1.27765801502961 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.-94C>G ndh_c.-94C>G 2 upstream_gene_variant 2103136 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4775 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3831 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh c.-94C>T ndh_c.-94C>T 2 upstream_gene_variant 2103136 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh c.951G>A ndh_c.951G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.-95A>G ndh_c.-95A>G 2 upstream_gene_variant 2103137 NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4595 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3702 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh c.960G>A ndh_c.960G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.963C>A ndh_c.963C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.984T>C ndh_c.984T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.984T>G ndh_c.984T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.247471899512553 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.990G>A ndh_c.990G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.996G>C ndh_c.996G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh c.9C>G ndh_c.9C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid ndh deletion ndh_deletion 2 feature_ablation (see "Genomic_coordinates" sheet) NA 0 0 0 3 2 20843 27466 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999927188000582 0.999737003036386 0.999991182007438 0.6 0.146632799634673 0.947255049473683 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4596 5574 False False 1.97663484143357 0.226402568392661 23.6672561646805 0 0 0.00017696843241753 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3703 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 1 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh LoF ndh_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 10 5 5 98 12 20748 27456 0.00470114170584284 0.00381821286436323 0.00572623867050934 0.999563128003495 0.99923699702714 0.999774242139628 0.89090909090909 0.817192718946146 0.942345274419367 0.5 0.187086028447398 0.812913971552601 0.294117647058823 0.103135514370319 0.559582718754337 1.32330827067669 0.304485716680888 5.74986678716853 0.753877195701186 1238 5574 False False 10.8070175438596 5.91343921451771 21.6333133033787 0.000240929022310027 7.82334773547155e-05 0.000562157642287576 0.999563128003495 0.99923699702714 0.999774242139628 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 3 5 61 10 13313 21303 0.00456108867952744 0.00349061404712372 0.00585510478363228 0.999530802796415 0.99913729947772 0.999774979505452 0.859154929577464 0.756195284502838 0.930337413944968 0.375 0.0852334141372535 0.755136783633448 0.23076923076923 0.0503810734911515 0.53813153923404 0.960099151205588 0.14905846809792 4.93561231315423 1 1642.5 4479 False False 0 0 0 0 0 0 0 9.76100803725681 4.96063460795983 21.375998176229 0.000225292880744968 4.64632182785159e-05 0.000658258835905292 0.999530802796415 0.99913729947772 0.999774979505452 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Ala118Val ndh_p.Ala118Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4794 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Ala121Thr ndh_p.Ala121Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4795 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3842 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Ala154Val ndh_p.Ala154Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 8 0 20838 27468 0.000383766669864722 0.000165697303700768 0.000756032532322191 1 0.999865711673152 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 4698 5574 False False Inf 2.24970730189478 Inf 0 0 0.000177010891571197 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3781 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Ala158Thr ndh_p.Ala158Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4712 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Ala178Gly ndh_p.Ala178Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Ala178Ser ndh_p.Ala178Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 9 0 9 0 9 20846 27459 0 0 0.00017694296670111 0.999672346002621 0.99937810218515 0.999850165132458 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.667448724025835 0.0128622314815615 141.5 5574 False False 0 0 0.667448724025835 0 0 0.00017694296670111 0.999672346002621 0.99937810218515 0.999850165132458 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 0 9 13374 21304 0 0 0.000275786657608973 0.999577722516773 0.999198537836033 0.999806890245066 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.80720191833017 0.0153601860925328 100 4479 False False 0 0 0 0 0 0 0 0 0 0.80720191833017 0 0 0.000275786657608973 0.999577722516773 0.999198537836033 0.999806890245066 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Ala186Thr ndh_p.Ala186Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4699 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3782 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Ala193Asp ndh_p.Ala193Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4632 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Ala193Thr ndh_p.Ala193Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4573 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Ala193Val ndh_p.Ala193Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Ala209Val ndh_p.Ala209Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 64 0 20782 27468 0.00307013335891777 0.0023651552036298 0.00391882408737535 1 0.999865711673152 1 1 0.943990910613363 1 NA NA NA NA NA NA NA NA NA NA 4731 5574 False False Inf 22.2726279264818 Inf 0 0 0.000177487829796209 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 53 0 13321 21313 0.00396291311499925 0.00296986066820338 0.00518042246583324 1 0.999826933785262 1 1 0.932765453693698 1 NA NA NA NA NA NA NA NA NA NA 3801 4479 False False 0 0 0 0 0 0 0 Inf 22.190722795952 Inf 0 0 0.000276883772623185 1 0.999826933785262 1 3 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Ala217Asp ndh_p.Ala217Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Ala217Val ndh_p.Ala217Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Ala219fs ndh_p.Ala219fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4707 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3786 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Ala219Glu ndh_p.Ala219Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Ala219Gly ndh_p.Ala219Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4574 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3686 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Ala219Val ndh_p.Ala219Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Ala226Glu ndh_p.Ala226Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Ala233Thr ndh_p.Ala233Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Ala234Thr ndh_p.Ala234Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4589 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3697 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Ala272Thr ndh_p.Ala272Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Ala278Val ndh_p.Ala278Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4662 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Ala282Val ndh_p.Ala282Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Ala29Pro ndh_p.Ala29Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4690 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3775 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Ala29Thr ndh_p.Ala29Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Ala300Asp ndh_p.Ala300Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Ala324fs ndh_p.Ala324fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 12 1 20834 27467 0.000575650004797083 0.000297481006307132 0.00100532857413147 0.999963594000291 0.999797175631493 0.999999078280314 0.923076923076923 0.639702564732122 0.998054371502653 NA NA NA 0 0 0.975 NA NA NA NA 4776 5574 False False 15.8204857444561 2.34041175273207 674.218749554653 0 0 0.000177044873566246 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 9 1 13365 21312 0.000672947510094212 0.000307759154923187 0.00127707788784856 0.999953080279641 0.999738608085756 0.999998812096234 0.9 0.554983882971804 0.997471421455538 NA NA NA 0 0 0.975 NA NA NA NA 3832 4479 False False 0 0 0 0 0 0 0 14.3515151515151 1.98814481377699 627.199072547492 0 0 0.000275972346901473 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Ala324Val ndh_p.Ala324Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 0 0 0.975 0 0 0.521823750104981 0 0 51.3409520749508 1 2027.5 5574 False False 0 0 1.43785249906968 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 5 13374 21308 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 0 0 0.521823750104981 0 0 0.975 0 0 0.521823750104981 0 0 62.0799950182179 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 1.73894646374006 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Ala325fs ndh_p.Ala325fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4590 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Ala325Thr ndh_p.Ala325Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4604 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3709 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Ala325Val ndh_p.Ala325Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4663 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3753 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Ala333Thr ndh_p.Ala333Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Ala336_Gly339del ndh_p.Ala336_Gly339del 2 inframe_deletion (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4597 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3704 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Ala336fs ndh_p.Ala336fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 5 0 20841 27468 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 1 0.999865711673152 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 4777 5574 False False Inf 1.20760984683633 Inf 0 0 0.000176985413634466 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3833 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Ala340fs ndh_p.Ala340fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 4654 5574 False False Inf 0.869878292971449 Inf 0 0 0.000176976922618654 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3748 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Ala340Glu ndh_p.Ala340Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4605 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3710 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Ala340Thr ndh_p.Ala340Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 51.3533466119536 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Ala344Pro ndh_p.Ala344Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Ala349Gly ndh_p.Ala349Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4783 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3836 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Ala349Val ndh_p.Ala349Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4726 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3797 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Ala354Gly ndh_p.Ala354Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Ala354Val ndh_p.Ala354Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 2 2 20844 27466 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999927188000582 0.999737003036386 0.999991182007438 0.5 0.067585986488543 0.932414013511457 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01666191595533 0.509389255488555 1161.5 5574 False False 1.3176933410094 0.0955278435529395 18.1762534351792 0 0 0.000176959943030976 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 2 2 13372 21311 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999906160559283 0.999661061221376 0.999988635406343 0.5 0.067585986488543 0.932414013511457 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.4866208667913 0.526194527956412 951.5 4479 False False 0 0 0 0 0 0 0 1.59370326054442 0.115491055908661 21.9865025501046 0 0 0.000275827900298067 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Ala36Val ndh_p.Ala36Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4708 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3787 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Ala371Thr ndh_p.Ala371Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4713 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Ala371Val ndh_p.Ala371Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4752 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3816 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Ala380Val ndh_p.Ala380Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 4 6 20842 27462 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999781564001747 0.999524617886493 0.999919833755107 0.4 0.121552258119827 0.737621923393055 0 0 0.841886116991581 0 0 0.4592581264399 0 0 7.01631333513977 0.509385912744699 1118 5574 False False 0.878418577871605 0.182308638457443 3.70497296035774 0 0 0.000176976922618654 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 2 4 13372 21309 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999812321118566 0.999519537882235 0.999948861529775 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.841886116991581 0 0 0.602364635616474 0 0 8.48582446968625 0.526184348245175 907.5 4479 False False 0 0 0 0 0 0 0 0.796776847143284 0.0720475461928349 5.56077695166295 0 0 0.000275827900298067 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Ala402Val ndh_p.Ala402Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4784 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Ala436Thr ndh_p.Ala436Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4732 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3802 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Ala449Thr ndh_p.Ala449Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Ala44Asp ndh_p.Ala44Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4598 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3705 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Ala44Gly ndh_p.Ala44Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Ala44Ser ndh_p.Ala44Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Ala44Thr ndh_p.Ala44Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4733 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3803 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Ala44Val ndh_p.Ala44Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4700 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Ala452Glu ndh_p.Ala452Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4778 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Ala452Val ndh_p.Ala452Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4575 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3687 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Ala457Val ndh_p.Ala457Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Ala459Thr ndh_p.Ala459Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4796 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3843 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Ala59fs ndh_p.Ala59fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4753 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Ala59Val ndh_p.Ala59Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4714 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3788 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Ala9Thr ndh_p.Ala9Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4582 5574 False False 0.439194051331254 0.00837049629364692 5.4704842261679 0 0 0.000176951454458875 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3691 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Arg13His ndh_p.Arg13His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Arg13Leu ndh_p.Arg13Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4797 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Arg150His ndh_p.Arg150His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4655 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Arg166Gln ndh_p.Arg166Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Arg16Gln ndh_p.Arg16Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance No change no 1 +Isoniazid ndh p.Arg235Gln ndh_p.Arg235Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 4642 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3737 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Arg254Cys ndh_p.Arg254Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4606 5574 False False 0.439194051331254 0.00837049629364692 5.4704842261679 0 0 0.000176951454458875 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3711 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Arg268His ndh_p.Arg268His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 167 163 20679 27305 0.00801112923342607 0.00684600679311126 0.00931641132786675 0.994065822047473 0.993085062840274 0.994939730789487 0.506060606060606 0.450758912900575 0.561252574387653 NA NA NA 0 0 0.0223769984930192 NA NA NA NA NA NA False True 1.35282466994019 1.08282561322251 1.69043079198188 0 0 0.00017837179981134 0.994065822047473 0.993085062840274 0.994939730789487 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 84 99 13290 21214 0.00628084342754598 0.0050128492064353 0.00777029190976763 0.995354947684511 0.994347673976342 0.996223175137551 0.459016393442622 0.3852767944061 0.534105208222374 NA NA NA 0 0 0.0365757449834789 NA NA NA NA NA NA False True 0 0 1 0 0 1 1 1.35438356476731 0.999561387403119 1.83144564921321 0 0 0.000277529536789337 0.995354947684511 0.994347673976342 0.996223175137551 115 Not assoc w RI Literature evidence (PMID 32143680) 4) Not assoc w R - Interim No change yes Lit. (PMID 32143680) 1 +Isoniazid ndh p.Arg268Leu ndh_p.Arg268Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4785 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3837 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Arg284Trp ndh_p.Arg284Trp 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 42 20845 27426 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.998470948012232 0.997933721766724 0.99889777846355 0.0232558139534883 0.000588612931593182 0.122890482701339 NA NA NA 0 0 0.0840838549403552 NA NA NA NA 4646 5574 False False 0.0313264571839769 0.000779406383781228 0.184368908125602 0 0 0.000176951454458875 0.998470948012232 0.997933721766724 0.99889777846355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 42 13373 21271 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.998029371744944 0.997337206394325 0.998579386728924 0.0232558139534883 0.000588612931593182 0.122890482701339 NA NA NA 0 0 0.0840838549403552 NA NA NA NA 3741 4479 False False 0 0 0 0 0 0 0 0.0378712615682629 0.000941149387356766 0.222910111937328 0 0 0.000275807277411719 0.998029371744944 0.997337206394325 0.998579386728924 3 3) Uncertain significance No change no 1 +Isoniazid ndh p.Arg287Thr ndh_p.Arg287Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Arg294Gln ndh_p.Arg294Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4612 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3715 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Arg294Trp ndh_p.Arg294Trp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4763 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3823 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Arg302fs ndh_p.Arg302fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4734 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3804 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Arg359fs ndh_p.Arg359fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4682 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Arg425His ndh_p.Arg425His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4715 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3789 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Arg425Leu ndh_p.Arg425Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4576 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3688 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Arg439Gln ndh_p.Arg439Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 4583 5574 False False Inf 0.869878292971449 Inf 0 0 0.000176976922618654 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 13370 21313 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 1 0.999826933785262 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3692 4479 False False 0 0 0 0 0 0 0 Inf 1.05210128917758 Inf 0 0 0.000275869155324334 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Arg439* ndh_p.Arg439* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4745 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3813 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Arg441Gln ndh_p.Arg441Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4701 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3783 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Arg45Cys ndh_p.Arg45Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Arg45Ser ndh_p.Arg45Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4664 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3754 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Asn28_Ala29delinsLys ndh_p.Asn28_Ala29delinsLys 2 inframe_deletion (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4623 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Asn355fs ndh_p.Asn355fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4665 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3755 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Asn88Asp ndh_p.Asn88Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Asn88Ser ndh_p.Asn88Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Asp142Tyr ndh_p.Asp142Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Asp163Glu ndh_p.Asp163Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4591 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3698 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Asp251Ala ndh_p.Asp251Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4779 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Asp251Glu ndh_p.Asp251Glu 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 4746 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Asp288Ala ndh_p.Asp288Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4768 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Asp288fs ndh_p.Asp288fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4798 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Asp308Gly ndh_p.Asp308Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 4769 5574 False False Inf 0.869878292971449 Inf 0 0 0.000176976922618654 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Asp322Asn ndh_p.Asp322Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4691 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3776 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Asp322fs ndh_p.Asp322fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4770 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3827 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Asp37fs ndh_p.Asp37fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4799 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3844 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Asp39Asn ndh_p.Asp39Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4800 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Asp93Glu ndh_p.Asp93Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4801 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Gln109* ndh_p.Gln109* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4683 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3769 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Gln10Lys ndh_p.Gln10Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01632529799099 0.509386028876591 1135.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Gln123Lys ndh_p.Gln123Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Gln188* ndh_p.Gln188* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4584 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3693 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Gln230His ndh_p.Gln230His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4716 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3790 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 4 3) Uncertain significance No change no 1 +Isoniazid ndh p.Gln237Arg ndh_p.Gln237Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Gln244fs ndh_p.Gln244fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4613 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3716 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Gln292Pro ndh_p.Gln292Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4666 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3756 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Gln304His ndh_p.Gln304His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Gln334fs ndh_p.Gln334fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4692 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3777 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Gln363His ndh_p.Gln363His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4717 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3791 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Gln363Ser ndh_p.Gln363Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 23 0 23 8 33 20838 27435 0.000383766669864722 0.000165697303700768 0.000756032532322191 0.998798602009611 0.998313200429948 0.999172873081023 0.195121951219512 0.0882061016628512 0.348665467451379 0 0 0.148185128915224 0 0 0.105762810074579 0 0 0.229086463310555 4.15907780800052e-06 39 5574 True False 0.319172141803872 0.12733107313489 0.704985173098811 0 0 0.000177010891571197 0.998798602009611 0.998313200429948 0.999172873081023 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 17 0 17 4 27 13370 21286 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 0.998733167550321 0.998157356503829 0.999164988624762 0.129032258064516 0.036301661979209 0.298335829007797 0 0 0.195064322969093 0 0 0.127702867615432 0 0 0.385883762879432 0.000539575382933448 50 4479 True False 0 0 0 0 0 0 0 0.23586248926563 0.059933051696447 0.677160297242128 0 0 0.000275869155324334 0.998733167550321 0.998157356503829 0.999164988624762 5 3) Uncertain significance No change no 1 +Isoniazid ndh p.Gln444Arg ndh_p.Gln444Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4669 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3758 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Gln4fs ndh_p.Gln4fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4693 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Gln57His ndh_p.Gln57His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4780 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3834 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Gln57* ndh_p.Gln57* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Gln5His ndh_p.Gln5His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4592 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3699 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Gln97Arg ndh_p.Gln97Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Glu146Ala ndh_p.Glu146Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4684 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3770 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Glu159Lys ndh_p.Glu159Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4802 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Glu165Gln ndh_p.Glu165Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Glu194Lys ndh_p.Glu194Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4738 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3808 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Glu270Asp ndh_p.Glu270Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4754 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Glu270Gln ndh_p.Glu270Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Glu291_Pro312delinsAsp ndh_p.Glu291_Pro312delinsAsp 2 inframe_deletion (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4771 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3828 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Glu291Lys ndh_p.Glu291Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4624 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3725 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Glu327Ala ndh_p.Glu327Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4694 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Glu350Asp ndh_p.Glu350Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4709 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Glu360Lys ndh_p.Glu360Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4739 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3809 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Glu443Lys ndh_p.Glu443Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Glu447_Ala449del ndh_p.Glu447_Ala449del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 51.3533466119536 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Glu65Gly ndh_p.Glu65Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4675 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Glu65Lys ndh_p.Glu65Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4614 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3717 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Glu67fs ndh_p.Glu67fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4727 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3798 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Glu67Gln ndh_p.Glu67Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Glu6fs ndh_p.Glu6fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4633 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3730 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Gly105Val ndh_p.Gly105Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Gly122Ser ndh_p.Gly122Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4755 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Gly127Asp ndh_p.Gly127Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 51.3446878573018 1 2027.5 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 62.0858160113928 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Gly137Asp ndh_p.Gly137Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4656 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Gly137fs ndh_p.Gly137fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Gly137Ser ndh_p.Gly137Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4585 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3694 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Gly179Asp ndh_p.Gly179Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Gly179fs ndh_p.Gly179fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4685 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Gly182Ser ndh_p.Gly182Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4676 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3763 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Gly225Asp ndh_p.Gly225Asp 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4756 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3817 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Gly229Asp ndh_p.Gly229Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4586 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3695 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Gly23Arg ndh_p.Gly23Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Gly240Ser ndh_p.Gly240Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance No change no 1 +Isoniazid ndh p.Gly246Ala ndh_p.Gly246Ala 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4757 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Gly246Ser ndh_p.Gly246Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4593 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3700 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Gly286Ser ndh_p.Gly286Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Gly301Asp ndh_p.Gly301Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Gly301del ndh_p.Gly301del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4702 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Gly301fs ndh_p.Gly301fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4634 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3731 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Gly301Ser ndh_p.Gly301Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Gly313Arg ndh_p.Gly313Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 74 20843 27394 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.997305956021552 0.996619038569187 0.997884022005718 0.0389610389610389 0.00810791726669392 0.109665366674522 NA NA NA 0 0 0.0486276162379895 NA NA NA NA NA NA False True 0.0532825201538918 0.0107371899693034 0.161921951714558 0 0 0.00017696843241753 0.997305956021552 0.996619038569187 0.997884022005718 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 2 65 13372 21248 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.996950218176699 0.99611443105232 0.997645478090083 0.0298507462686567 0.00363573072690439 0.103707507647554 NA NA NA 0 0 0.0551716343188133 NA NA NA NA NA NA False True 0 0 1 0 0 1 1 0.0488920591822177 0.0058068800376936 0.183903876476642 0 0 0.000275827900298067 0.996950218176699 0.99611443105232 0.997645478090083 24 Not assoc w R Literature evidence (PMID 32143680) 4) Not assoc w R - Interim DOWN from NotAwR to NotAwRI yes Lit. (PMID 32143680) 3 +Isoniazid ndh p.Gly313Trp ndh_p.Gly313Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4670 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3759 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Gly331Arg ndh_p.Gly331Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4615 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3718 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Gly331fs ndh_p.Gly331fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Gly339Ala ndh_p.Gly339Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 2 5 3 5 20843 27463 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999817970001456 0.999575254267103 0.999940892797913 0.375 0.0852334141372535 0.755136783633448 0.285714285714285 0.0366925661760855 0.709579136262657 0.285714285714285 0.0366925661760855 0.709579136262657 0.527045051096291 0.0501854026685452 3.22000686308128 0.706258531068192 1235.5 5574 False False 0.790567576644437 0.122780413850952 4.06394022809159 9.59462700887503e-05 1.16197496419179e-05 0.000346547484278011 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 2 4 3 4 13371 21309 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999812321118566 0.999519537882235 0.999948861529775 0.428571428571428 0.0989882784425078 0.815948432359917 0.333333333333333 0.0432718682927417 0.777221904496487 0.333333333333333 0.0432718682927417 0.777221904496487 0.79683643706529 0.0720529376703383 5.56119311012066 1 1005 4479 False False 0 0 0 0 0 0 0 1.19525465559793 0.17505505093835 7.0663575727929 0.000149555073655873 1.81123264336181e-05 0.000540138824607934 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Gly353Asp ndh_p.Gly353Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4786 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3838 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Gly389Asp ndh_p.Gly389Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4703 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Gly389Ser ndh_p.Gly389Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4587 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Gly406Glu ndh_p.Gly406Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4667 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Gly427Ser ndh_p.Gly427Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4657 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3749 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 2 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Gly61Arg ndh_p.Gly61Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.His106Arg ndh_p.His106Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 39 0 20807 27468 0.00187086251559052 0.00133069396952595 0.00255665236872258 1 0.999865711673152 1 1 0.909748899039665 1 NA NA NA NA NA NA NA NA NA NA 4803 5574 False False Inf 13.3023876253756 Inf 0 0 0.000177274593749657 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 37 0 13337 21313 0.00276656198594287 0.00194864015550479 0.00381134478706768 1 0.999826933785262 1 1 0.90510941258501 1 NA NA NA NA NA NA NA NA NA NA 3845 4479 False False 0 0 0 0 0 0 0 Inf 15.2386753016974 Inf 0 0 0.000276551649377767 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.His106dup ndh_p.His106dup 2 inframe_insertion (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 4677 5574 False False Inf 0.869878292971449 Inf 0 0 0.000176976922618654 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 13370 21313 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 1 0.999826933785262 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3764 4479 False False 0 0 0 0 0 0 0 Inf 1.05210128917758 Inf 0 0 0.000275869155324334 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.His106fs ndh_p.His106fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 4735 5574 False False Inf 0.869878292971449 Inf 0 0 0.000176976922618654 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3805 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.His203Tyr ndh_p.His203Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.His400Tyr ndh_p.His400Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4678 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3765 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.His91Asp ndh_p.His91Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4616 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3719 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.His91fs ndh_p.His91fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4758 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3818 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.His91Gln ndh_p.His91Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4658 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3750 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Ile116Thr ndh_p.Ile116Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4627 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Ile204Ser ndh_p.Ile204Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4635 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3732 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Ile20Thr ndh_p.Ile20Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Ile212fs ndh_p.Ile212fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 6 0 20840 27468 0.000287825002398541 0.000105633792978048 0.000626367784710498 1 0.999865711673152 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 4617 5574 False False Inf 1.55167078958407 Inf 0 0 0.000176993905465082 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 5 0 13369 21313 0.000373859727830118 0.000121402023062639 0.000872246401868143 1 0.999826933785262 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 3720 4479 False False 0 0 0 0 0 0 0 Inf 1.46057233596553 Inf 0 0 0.000275889787465637 1 0.999826933785262 1 3 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Ile269Val ndh_p.Ile269Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4686 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3771 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Ile311Val ndh_p.Ile311Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4647 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3742 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Ile337fs ndh_p.Ile337fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 6 0 20840 27468 0.000287825002398541 0.000105633792978048 0.000626367784710498 1 0.999865711673152 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 4679 5574 False False Inf 1.55167078958407 Inf 0 0 0.000176993905465082 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 13370 21313 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 1 0.999826933785262 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3766 4479 False False 0 0 0 0 0 0 0 Inf 1.05210128917758 Inf 0 0 0.000275869155324334 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Ile347Val ndh_p.Ile347Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4759 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3819 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Ile382Thr ndh_p.Ile382Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Ile62Leu ndh_p.Ile62Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4636 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3733 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Ile62Ser ndh_p.Ile62Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4695 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3778 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Ile62Thr ndh_p.Ile62Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4668 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3757 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Ile63Met ndh_p.Ile63Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4680 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3767 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Ile63Thr ndh_p.Ile63Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4804 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3846 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Leu103fs ndh_p.Leu103fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4740 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Leu104fs ndh_p.Leu104fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4781 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Leu152fs ndh_p.Leu152fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0337875782094303 Inf 0.431457371721896 645 5574 False False Inf 0.247471899512553 Inf 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.040864745349235 Inf 0.385544600126852 512 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 7.47775368279368e-05 1.89320152683959e-06 0.000416562561410248 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Leu170Pro ndh_p.Leu170Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4599 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Leu171Pro ndh_p.Leu171Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Leu214Arg ndh_p.Leu214Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4696 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3779 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Leu228fs ndh_p.Leu228fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4718 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Leu285Phe ndh_p.Leu285Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4747 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Leu297Pro ndh_p.Leu297Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 4764 5574 False False Inf 0.869878292971449 Inf 0 0 0.000176976922618654 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3824 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Leu306Arg ndh_p.Leu306Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4618 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3721 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Leu309Arg ndh_p.Leu309Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4765 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3825 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Leu33Pro ndh_p.Leu33Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4671 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Leu394Arg ndh_p.Leu394Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4787 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3839 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Leu415fs ndh_p.Leu415fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4728 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3799 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Leu415Met ndh_p.Leu415Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Leu415Pro ndh_p.Leu415Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4659 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Leu42Pro ndh_p.Leu42Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4607 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3712 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Leu54Pro ndh_p.Leu54Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4608 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3713 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Leu54Val ndh_p.Leu54Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4729 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3800 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Leu76Pro ndh_p.Leu76Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 4577 5574 False False Inf 0.869878292971449 Inf 0 0 0.000176976922618654 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 13370 21313 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 1 0.999826933785262 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3689 4479 False False 0 0 0 0 0 0 0 Inf 1.05210128917758 Inf 0 0 0.000275869155324334 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Leu86fs ndh_p.Leu86fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4637 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3734 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Lys169Glu ndh_p.Lys169Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Lys208Glu ndh_p.Lys208Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 4 20843 27464 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999854376001165 0.999627187086024 0.999960320981843 0.428571428571428 0.0989882784425078 0.815948432359917 0 0 0.975 0 0 0.602364635616474 0 0 51.3502039740317 1 2027.5 5574 False False 0.988245454109293 0.144734627190883 5.84310835075667 0 0 0.00017696843241753 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 4 13373 21309 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999812321118566 0.999519537882235 0.999948861529775 0.2 0.00505076337946806 0.716417936118089 0 0 0.975 0 0 0.602364635616474 0 0 62.0875434180097 1 1642.5 4479 False False 0 0 0 0 0 0 0 0.398358633066626 0.00809276091420046 4.02622197901862 0 0 0.000275807277411719 0.999812321118566 0.999519537882235 0.999948861529775 1 3) Uncertain significance No change no 1 +Isoniazid ndh p.Lys227fs ndh_p.Lys227fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4660 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3751 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Lys238Asn ndh_p.Lys238Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4788 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3840 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Lys274Asn ndh_p.Lys274Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4648 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3743 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Lys32Glu ndh_p.Lys32Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 4643 5574 False False Inf 0.869878292971449 Inf 0 0 0.000176976922618654 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3738 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Lys341fs ndh_p.Lys341fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4704 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3784 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Lys341Glu ndh_p.Lys341Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 4672 5574 False False 0 0 1.43785249906968 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 13374 21308 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 3760 4479 False False 0 0 0 0 0 0 0 0 0 1.73894646374006 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Lys460Arg ndh_p.Lys460Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4805 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3847 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Lys460Glu ndh_p.Lys460Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Lys78Asn ndh_p.Lys78Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 1 6 20845 27462 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999781564001747 0.999524617886493 0.999919833755107 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.521823750104981 0 0 0.4592581264399 0 0 1.43786917636023 0.0743390630358733 263 5574 False False 0.219573039098105 0.00477770915407814 1.81014820057657 0 0 0.000176951454458875 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 1 5 13373 21308 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999765401398207 0.999452610763328 0.999923822225278 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.602364635616474 0 0 0.521823750104981 0 0 2.41427134641658 0.305472044773727 432 4479 False False 0 0 0 0 0 0 0 0.318671950945935 0.00674139558547252 2.84834809554519 0 0 0.000275807277411719 0.999765401398207 0.999452610763328 0.999923822225278 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Met1? ndh_p.Met1? 2 start_lost (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Met185Leu ndh_p.Met185Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Met248Ile ndh_p.Met248Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Met370Ile ndh_p.Met370Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Phe134Ser ndh_p.Phe134Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Phe201fs ndh_p.Phe201fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4687 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3772 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Phe365Leu ndh_p.Phe365Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4619 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3722 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Phe365Val ndh_p.Phe365Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Phe387Cys ndh_p.Phe387Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4730 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Pro111fs ndh_p.Pro111fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4620 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3723 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Pro111His ndh_p.Pro111His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 6 20846 27462 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 0 0 0.4592581264399 0 0 0.975 0 0 0.4592581264399 0 0 51.3390841836116 1 2027.5 5574 False False 0 0 1.11900921779861 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 62.0829055149378 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Pro12Leu ndh_p.Pro12Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4766 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3826 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Pro136fs ndh_p.Pro136fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4638 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Pro136Leu ndh_p.Pro136Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4628 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3728 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Pro136Ser ndh_p.Pro136Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4600 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3706 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Pro164Leu ndh_p.Pro164Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Pro222Ser ndh_p.Pro222Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Pro312fs ndh_p.Pro312fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Pro312Ser ndh_p.Pro312Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4741 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Pro330_Val332del ndh_p.Pro330_Val332del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Pro330fs ndh_p.Pro330fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4748 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3814 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Pro330Leu ndh_p.Pro330Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4661 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3752 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Pro330Ser ndh_p.Pro330Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 21 0 21 0 21 20846 27447 0 0 0.00017694296670111 0.999235474006116 0.998831576963824 0.999526686034611 0 0 0.161097615219079 0 0 0.161097615219079 0 0 0.161097615219079 0 0 0.252885886770404 7.66905456944964e-06 40 5574 True False 0 0 0.252885886770404 0 0 0.00017694296670111 0.999235474006116 0.998831576963824 0.999526686034611 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 20 0 20 0 20 13374 21293 0 0 0.000275786657608973 0.99906160559283 0.998551096167295 0.999426713067202 0 0 0.168433470983085 0 0 0.168433470983085 0 0 0.168433470983085 0 0 0.322586788941088 8.55242289018435e-05 36 4479 True False 0 0 0 0 0 0 0 0 0 0.322586788941088 0 0 0.000275786657608973 0.99906160559283 0.998551096167295 0.999426713067202 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Pro356Leu ndh_p.Pro356Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Pro384Arg ndh_p.Pro384Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4579 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Isoniazid ndh p.Pro3Leu ndh_p.Pro3Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 1 3) Uncertain significance No change no 1 +Isoniazid ndh p.Pro70Leu ndh_p.Pro70Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance No change no 1 +Isoniazid ndh p.Pro7Leu ndh_p.Pro7Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 1 11 20845 27457 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999599534003203 0.9992835689522 0.999800072407065 0.0833333333333333 0.00210759323186022 0.384796165150944 0 0 0.602364635616474 0 0 0.284914152918154 0 0 1.99563568293958 0.139097037296626 298 5574 False False 0.119745306264855 0.00278612189885952 0.824021419435307 0 0 0.000176951454458875 0.999599534003203 0.9992835689522 0.999800072407065 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 7 13373 21306 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.99967156195749 0.999323409938814 0.999867941002665 0.125 0.0031597235312519 0.526509670875206 0 0 0.707598226178713 0 0 0.409616397225003 0 0 3.85608284137978 0.289249091833513 280.5 4479 False False 0 0 0 0 0 0 0 0.227601457093717 0.00505385949080816 1.77192833352817 0 0 0.000275807277411719 0.99967156195749 0.999323409938814 0.999867941002665 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Ser101Pro ndh_p.Ser101Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4760 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3820 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Ser114Ile ndh_p.Ser114Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Ser140Phe ndh_p.Ser140Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4742 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3810 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Ser153Asn ndh_p.Ser153Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4782 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3835 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Ser162fs ndh_p.Ser162fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Ser206Pro ndh_p.Ser206Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 3 3 20843 27465 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999890782000873 0.99968085216583 0.999977476056514 0.5 0.118117248757025 0.881882751242974 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4639 5574 False False 1.31770858321738 0.176469385678871 9.83712695959095 0 0 0.00017696843241753 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 3 2 13371 21311 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999906160559283 0.999661061221376 0.999988635406343 0.6 0.146632799634673 0.947255049473683 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3735 4479 False False 0 0 0 0 0 0 0 2.39073367736145 0.273835790357664 28.6284716983702 0 0 0.000275848526268708 0.999906160559283 0.999661061221376 0.999988635406343 1 3) Uncertain significance No change no 1 +Isoniazid ndh p.Ser22Phe ndh_p.Ser22Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4749 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Ser271Leu ndh_p.Ser271Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4629 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Ser277Pro ndh_p.Ser277Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4789 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3841 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Ser345Arg ndh_p.Ser345Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Ser374fs ndh_p.Ser374fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4743 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3811 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Ser388Gly ndh_p.Ser388Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4705 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3785 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Ser423Arg ndh_p.Ser423Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4772 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Ser64Pro ndh_p.Ser64Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4588 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3696 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Thr110Asn ndh_p.Thr110Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Thr110fs ndh_p.Thr110fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4625 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3726 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Thr110Pro ndh_p.Thr110Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4736 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3806 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Thr172Ala ndh_p.Thr172Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4719 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3792 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Thr172Pro ndh_p.Thr172Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4649 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Thr174Ala ndh_p.Thr174Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4790 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Thr250Ala ndh_p.Thr250Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4720 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3793 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Thr258Ser ndh_p.Thr258Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Thr265Ile ndh_p.Thr265Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4650 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3744 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Thr346Met ndh_p.Thr346Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4721 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3794 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Thr418Ala ndh_p.Thr418Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.43785249906968 0.0743380732312645 251 5574 False False 0 0 1.43785249906968 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.41420404242617 0.305473156458586 444 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Thr418Met ndh_p.Thr418Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 20846 27462 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.11900921779861 0.0402109359097128 194.5 5574 False False 0 0 1.11900921779861 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 13374 21307 0 0 0.000275786657608973 0.999718481677849 0.999387354605726 0.999896680954833 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.35335561005417 0.0884814409570568 164 4479 False False 0 0 0 0 0 0 0 0 0 1.35335561005417 0 0 0.000275786657608973 0.999718481677849 0.999387354605726 0.999896680954833 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Thr420Pro ndh_p.Thr420Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4791 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Thr424Pro ndh_p.Thr424Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 7 1 20839 27467 0.000335795836131632 0.000135017659185429 0.000691744589626827 0.999963594000291 0.999797175631493 0.999999078280314 0.875 0.473490329124793 0.996840276468748 0 0 0.975 0 0 0.975 0 0 51.3656581746512 1 2027.5 5574 False False 9.22640241854215 1.18513781610454 415.029346412368 0 0 0.00017700239811062 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 7 1 13367 21312 0.000523403618962165 0.000210460468745924 0.00107811225334149 0.999953080279641 0.999738608085756 0.999998812096234 0.875 0.473490329124793 0.996840276468748 0 0 0.975 0 0 0.975 0 0 62.1241214470754 1 1642.5 4479 False False 0 0 0 0 0 0 0 11.1606194359242 1.43348631137374 501.805825213892 0 0 0.000275931061008045 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Thr430fs ndh_p.Thr430fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4673 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3761 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Thr432Pro ndh_p.Thr432Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 4580 5574 False False Inf 0.869878292971449 Inf 0 0 0.000176976922618654 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3690 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Thr47Ser ndh_p.Thr47Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 15 1 14 2 15 20844 27453 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999453910004368 0.999099467294252 0.999694326386446 0.117647058823529 0.0145793168403025 0.36440916210125 0.0666666666666666 0.0016864302413527 0.319484566578303 0.0625 0.00158111172276588 0.302320738434531 0.0940764043095649 0.00222907325008701 0.618448217479887 0.00327011304716915 93 5574 False False 0.175609288044521 0.0194906025612046 0.755278524937973 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 0.999453910004368 0.999099467294252 0.999694326386446 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 1 10 13373 21303 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999530802796415 0.99913729947772 0.999774979505452 0.0909090909090909 0.00229897221381426 0.412779916988382 0 0 0.336267116879942 0 0 0.30849710781876 0 0 0.807224395021091 0.0153610219751104 101 4479 False False 0 0 0 0 0 0 0 0.159298586704553 0.00367454063771155 1.12000806973243 0 0 0.000275807277411719 0.999530802796415 0.99913729947772 0.999774979505452 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Thr60Ile ndh_p.Thr60Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4761 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3821 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Thr8Arg ndh_p.Thr8Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Thr8fs ndh_p.Thr8fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4609 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Thr8Ile ndh_p.Thr8Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Thr8Lys ndh_p.Thr8Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Trp276Cys ndh_p.Trp276Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4722 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Trp417Cys ndh_p.Trp417Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Tyr108Cys ndh_p.Tyr108Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 3 1 20843 27467 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999963594000291 0.999797175631493 0.999999078280314 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 4621 5574 False False 3.95341361608213 0.31739219148065 207.323829234655 0 0 0.00017696843241753 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Tyr108fs ndh_p.Tyr108fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Tyr112fs ndh_p.Tyr112fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 4792 5574 False False Inf 0.869878292971449 Inf 0 0 0.000176976922618654 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Tyr112His ndh_p.Tyr112His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4710 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Tyr112* ndh_p.Tyr112* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Tyr314fs ndh_p.Tyr314fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4767 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Tyr342Asp ndh_p.Tyr342Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4723 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Tyr342* ndh_p.Tyr342* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Tyr364Asp ndh_p.Tyr364Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4601 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Tyr403His ndh_p.Tyr403His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Tyr56Cys ndh_p.Tyr56Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4578 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Tyr56* ndh_p.Tyr56* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4651 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3745 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Val100Phe ndh_p.Val100Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4737 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3807 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Val117Ile ndh_p.Val117Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 4 16 20842 27452 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.99941750400466 0.999054234895718 0.999667017718464 0.2 0.0573339970500327 0.436614002996668 0 0 0.707598226178713 0 0 0.205907214207822 0 0 3.18775565477428 0.264045819872839 424 5574 False False 0.329287016601093 0.0801115836744329 1.02098825253189 0 0 0.000176976922618654 0.99941750400466 0.999054234895718 0.999667017718464 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 3 13 13371 21300 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.99939004363534 0.998957181904114 0.999675185224884 0.1875 0.0404737339059459 0.456456546231611 0 0 0.841886116991581 0 0 0.24705263800047 0 0 8.48287507519006 0.526146654422089 670 4479 False False 0 0 0 0 0 0 0 0.367615332838577 0.0671805522637574 1.33817896767753 0 0 0.000275848526268708 0.99939004363534 0.998957181904114 0.999675185224884 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Val175Ile ndh_p.Val175Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Val176Ala ndh_p.Val176Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 4688 5574 False False Inf 0.869878292971449 Inf 0 0 0.000176976922618654 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 13370 21313 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 1 0.999826933785262 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3773 4479 False False 0 0 0 0 0 0 0 Inf 1.05210128917758 Inf 0 0 0.000275869155324334 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Val176Ile ndh_p.Val176Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4640 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3736 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Val17Ile ndh_p.Val17Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4594 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3701 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Val18Ala ndh_p.Val18Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 395 873 20451 26595 0.0189484793245706 0.0171409694695637 0.0208918408050395 0.968217562254259 0.966074692403548 0.970260621616977 0.311514195583596 0.2860911263559 0.337814244631747 NA NA NA 0 0 0.00421660561515821 NA NA NA NA NA NA False True 0.588394084527916 0.520409260495598 0.664357294506486 0 0 0.000180360216153992 0.968217562254259 0.966074692403548 0.970260621616977 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 235 695 13139 20618 0.0175714072080155 0.0154127221784594 0.0199434840461553 0.967390794350865 0.964918181271683 0.969734824360427 0.25268817204301 0.225041471227873 0.281910661829353 NA NA NA 0 0 0.00529367905728507 NA NA NA NA NA NA False True 0 1 1 0 0 1 1 0.530600042380282 0.454947642707374 0.617124629977886 0 0 0.000280718598169678 0.967390794350865 0.964918181271683 0.969734824360427 96 Not assoc w R 5) Not assoc w R No change yes 1 +Isoniazid ndh p.Val18Gly ndh_p.Val18Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Val220Leu ndh_p.Val220Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4706 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Val241Ala ndh_p.Val241Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4744 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3812 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Val241Gly ndh_p.Val241Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4602 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3707 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Val249fs ndh_p.Val249fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4644 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3739 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Val252Ile ndh_p.Val252Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Val259Ile ndh_p.Val259Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Val275Gly ndh_p.Val275Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4806 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3848 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Val319Met ndh_p.Val319Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4697 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3780 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Val326fs ndh_p.Val326fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4681 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3768 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Val326Met ndh_p.Val326Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4762 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3822 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Val329fs ndh_p.Val329fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4645 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3740 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Val332fs ndh_p.Val332fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4750 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Val332Gly ndh_p.Val332Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4641 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Val373Phe ndh_p.Val373Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4610 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3714 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Val38Ala ndh_p.Val38Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Val398Ala ndh_p.Val398Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Val75Ala ndh_p.Val75Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4773 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3829 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid ndh p.Val89Phe ndh_p.Val89Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4630 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Val89Ser ndh_p.Val89Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4774 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3830 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid ndh p.Val99Ala ndh_p.Val99Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv0010c c.-100A>G Rv0010c_c.-100A>G 2 upstream_gene_variant 13658 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-101C>G Rv0010c_c.-101C>G 2 upstream_gene_variant 13659 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-102_-78delGCAACCTTTTGGTCACTCAATCACA Rv0010c_c.-102_-78delGCAACCTTTTGGTCACTCAATCACA 2 upstream_gene_variant 13635 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-102G>C Rv0010c_c.-102G>C 2 upstream_gene_variant 13660 1 5 0 5 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.43785249906968 0.0743380732312645 251 5574 False False 0 0 1.43785249906968 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-104_-103insC Rv0010c_c.-104_-103insC 2 upstream_gene_variant 13661 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4463 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3587 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-104C>T Rv0010c_c.-104C>T 2 upstream_gene_variant 13662 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-104delC Rv0010c_c.-104delC 2 upstream_gene_variant 13661 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4449 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3573 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-105C>G Rv0010c_c.-105C>G 2 upstream_gene_variant 13663 NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4525 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3644 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.105C>T Rv0010c_c.105C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.-105C>T Rv0010c_c.-105C>T 2 upstream_gene_variant 13663 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4455 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3579 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-106G>A Rv0010c_c.-106G>A 2 upstream_gene_variant 13664 1 7 0 7 7 8 20839 27460 0.000335795836131632 0.000135017659185429 0.000691744589626827 0.99970875200233 0.999426206431739 0.999874251669172 0.466666666666666 0.212666729519307 0.734138652722603 0 0 0.409616397225003 0 0 0.369416647552819 0 0 0.914394916729518 0.0219889751673365 169 5574 False False 1.15300638226402 0.355868700863001 3.63924979501029 0 0 0.00017700239811062 0.99970875200233 0.999426206431739 0.999874251669172 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 3 7 13371 21306 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.99967156195749 0.999323409938814 0.999867941002665 0.3 0.0667395111777345 0.652452850059997 0 0 0.4592581264399 0 0 0.409616397225003 0 0 1.35359566790166 0.0884864085358222 183 4479 False False 0 0 0 0 0 0 0 0.682906503413571 0.113956481543253 2.99204017959139 0 0 0.000275848526268708 0.99967156195749 0.999323409938814 0.999867941002665 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-107_-106insT Rv0010c_c.-107_-106insT 2 upstream_gene_variant 13664 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4405 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3534 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.108G>A Rv0010c_c.108G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.-108G>A Rv0010c_c.-108G>A 2 upstream_gene_variant 13666 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4482 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3603 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.108G>C Rv0010c_c.108G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.-108G>T Rv0010c_c.-108G>T 2 upstream_gene_variant 13666 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-10T>C Rv0010c_c.-10T>C 2 upstream_gene_variant 13568 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-10T>G Rv0010c_c.-10T>G 2 upstream_gene_variant 13568 1 8 0 8 0 8 20846 27460 0 0 0.00017694296670111 0.99970875200233 0.999426206431739 0.999874251669172 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.771808536885009 0.0121106507453556 124 5574 False False 0 0 0.771808536885009 0 0 0.00017694296670111 0.99970875200233 0.999426206431739 0.999874251669172 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 13374 21307 0 0 0.000275786657608973 0.999718481677849 0.999387354605726 0.999896680954833 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.35335561005417 0.0884814409570568 164 4479 False False 0 0 0 0 0 0 0 0 0 1.35335561005417 0 0 0.000275786657608973 0.999718481677849 0.999387354605726 0.999896680954833 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-110C>T Rv0010c_c.-110C>T 2 upstream_gene_variant 13668 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-111A>G Rv0010c_c.-111A>G 2 upstream_gene_variant 13669 1 9 0 9 5 11 20841 27457 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.999599534003203 0.9992835689522 0.999800072407065 0.3125 0.110169954717117 0.586620636451358 0 0 0.336267116879942 0 0 0.284914152918154 0 0 0.667560237346406 0.0128615891439186 137 5574 False False 0.598841444530231 0.163088823654088 1.86994347550002 0 0 0.000176985413634466 0.999599534003203 0.9992835689522 0.999800072407065 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 3 7 13371 21306 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.99967156195749 0.999323409938814 0.999867941002665 0.3 0.0667395111777345 0.652452850059997 0 0 0.4592581264399 0 0 0.409616397225003 0 0 1.35359566790166 0.0884864085358222 183 4479 False False 0 0 0 0 0 0 0 0.682906503413571 0.113956481543253 2.99204017959139 0 0 0.000275848526268708 0.99967156195749 0.999323409938814 0.999867941002665 2 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-113T>C Rv0010c_c.-113T>C 2 upstream_gene_variant 13671 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4567 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3681 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.114G>A Rv0010c_c.114G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 4 20845 27464 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999854376001165 0.999627187086024 0.999960320981843 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.329383545214679 0.00669260119676484 3.32889360843958 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.85651838973546 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.115T>C Rv0010c_c.115T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 5 2 20841 27466 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.999927188000582 0.999737003036386 0.999991182007438 0.714285714285714 0.290420863737342 0.963307433823914 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.29470754762247 0.539313466840718 34.60579842565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 1 13371 21312 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999953080279641 0.999738608085756 0.999998812096234 0.75 0.194120449683243 0.99369053679029 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.78169172088849 0.383875689805931 250.696170545132 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.-116T>C Rv0010c_c.-116T>C 2 upstream_gene_variant 13674 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.117G>A Rv0010c_c.117G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.-117G>A Rv0010c_c.-117G>A 2 upstream_gene_variant 13675 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4564 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-117G>C Rv0010c_c.-117G>C 2 upstream_gene_variant 13675 NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4458 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3582 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-119G>A Rv0010c_c.-119G>A 2 upstream_gene_variant 13677 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4443 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3568 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-119G>T Rv0010c_c.-119G>T 2 upstream_gene_variant 13677 1 24 0 24 8 32 20838 27436 0.000383766669864722 0.000165697303700768 0.000756032532322191 0.99883500800932 0.998355773360856 0.999203014115056 0.2 0.0905224093999906 0.356478018679234 0 0 0.142473597722525 0 0 0.108881160679352 0 0 0.218796742203919 2.17725392928781e-06 38 5574 True False 0.329158268547845 0.130999257133501 0.729566416094933 0 0 0.000177010891571197 0.99883500800932 0.998355773360856 0.999203014115056 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 23 0 23 7 30 13367 21283 0.000523403618962165 0.000210460468745924 0.00107811225334149 0.998592408389246 0.997991180201286 0.999050108601822 0.189189189189189 0.0796211208528768 0.351552378369254 0 0 0.148185128915224 0 0 0.115703308222027 0 0 0.27705506658527 1.59554644302672e-05 29 4479 True False 0 0 0 0 0 0 0 0.371514426074162 0.137701933438816 0.863550803736087 0 0 0.000275931061008045 0.998592408389246 0.997991180201286 0.999050108601822 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-11C>A Rv0010c_c.-11C>A 2 upstream_gene_variant 13569 1 1 0 1 2 2 20844 27466 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999927188000582 0.999737003036386 0.999991182007438 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 51.3514785421127 1 2027.5 5574 False False 1.3176933410094 0.0955278435529395 18.1762534351792 0 0 0.000176959943030976 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-11C>T Rv0010c_c.-11C>T 2 upstream_gene_variant 13569 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.120C>T Rv0010c_c.120C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.-120C>T Rv0010c_c.-120C>T 2 upstream_gene_variant 13678 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4420 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3546 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-122G>A Rv0010c_c.-122G>A 2 upstream_gene_variant 13680 1 1 0 1 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 51.349017027227 1 2027.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3638 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-122G>T Rv0010c_c.-122G>T 2 upstream_gene_variant 13680 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4508 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3625 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.123A>G Rv0010c_c.123A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 14 20846 27454 0 0 0.00017694296670111 0.999490316004077 0.999144984581285 0.999721323894632 0 0 0.231635761650116 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.397069295701206 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 12 13374 21301 0 0 0.000275786657608973 0.999436963355698 0.999016695060306 0.999709037985722 0 0 0.264648469397051 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.5733410294454 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.123A>T Rv0010c_c.123A>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.-123G>A Rv0010c_c.-123G>A 2 upstream_gene_variant 13681 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-123G>C Rv0010c_c.-123G>C 2 upstream_gene_variant 13681 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-124T>A Rv0010c_c.-124T>A 2 upstream_gene_variant 13682 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4436 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3561 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-125C>A Rv0010c_c.-125C>A 2 upstream_gene_variant 13683 1 1 0 1 3 6 20843 27462 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999781564001747 0.999524617886493 0.999919833755107 0.333333333333333 0.0748546314196918 0.700704943791459 0 0 0.975 0 0 0.4592581264399 0 0 51.3464676546221 1 2027.5 5574 False False 0.658782325001199 0.106624051224918 3.0850110900601 0 0 0.00017696843241753 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 6 13373 21307 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999718481677849 0.999387354605726 0.999896680954833 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.975 0 0 0.4592581264399 0 0 62.0817219898698 1 1642.5 4479 False False 0 0 0 0 0 0 0 0.265547496198808 0.00577686092206708 2.18912593855065 0 0 0.000275807277411719 0.999718481677849 0.999387354605726 0.999896680954833 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-125C>T Rv0010c_c.-125C>T 2 upstream_gene_variant 13683 NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4537 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3656 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-126T>G Rv0010c_c.-126T>G 2 upstream_gene_variant 13684 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-128A>G Rv0010c_c.-128A>G 2 upstream_gene_variant 13686 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3588 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.129C>T Rv0010c_c.129C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.-12T>C Rv0010c_c.-12T>C 2 upstream_gene_variant 13570 1 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4561 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3675 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-131C>T Rv0010c_c.-131C>T 2 upstream_gene_variant 13689 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3583 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.132G>C Rv0010c_c.132G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.132G>T Rv0010c_c.132G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.133C>T Rv0010c_c.133C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.135G>A Rv0010c_c.135G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.135G>C Rv0010c_c.135G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.-136G>A Rv0010c_c.-136G>A 2 upstream_gene_variant 13694 1 7 0 7 1 7 20845 27461 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999745158002038 0.999474999027776 0.999897534357495 0.125 0.0031597235312519 0.526509670875206 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.914165078856148 0.0219771744406454 160.5 5574 False False 0.188198608779083 0.00417990056987037 1.46513319151887 0 0 0.000176951454458875 0.999745158002038 0.999474999027776 0.999897534357495 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 7 13374 21306 0 0 0.000275786657608973 0.99967156195749 0.999323409938814 0.999867941002665 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 1.10552510564584 0.0484388314759391 130.5 4479 False False 0 0 0 0 0 0 0 0 0 1.10552510564584 0 0 0.000275786657608973 0.99967156195749 0.999323409938814 0.999867941002665 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-136G>C Rv0010c_c.-136G>C 2 upstream_gene_variant 13694 NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4565 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3678 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-137T>C Rv0010c_c.-137T>C 2 upstream_gene_variant 13695 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.138T>C Rv0010c_c.138T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.63548263289195 0.137183409715989 155.34952410964 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.-13delG Rv0010c_c.-13delG 2 upstream_gene_variant 13570 0 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4514 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3631 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-13G>A Rv0010c_c.-13G>A 2 upstream_gene_variant 13571 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-13G>C Rv0010c_c.-13G>C 2 upstream_gene_variant 13571 NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4450 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3574 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-140_-139insGCCGATAG Rv0010c_c.-140_-139insGCCGATAG 2 upstream_gene_variant 13697 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4451 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3575 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-140G>T Rv0010c_c.-140G>T 2 upstream_gene_variant 13698 1 3 0 3 2 4 20844 27464 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999854376001165 0.999627187086024 0.999960320981843 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.18884305347011 0.26408020969462 552 5574 False False 0.658798695068125 0.0595601499680727 4.59736120623929 0 0 0.000176959943030976 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 2 3 13372 21310 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999859240838924 0.999588697652472 0.999970971136275 0.4 0.0527449505263169 0.853367200365326 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85709530412199 0.289291791934617 400.5 4479 False False 0 0 0 0 0 0 0 1.06241898494366 0.0886985485353837 9.27715037564111 0 0 0.000275827900298067 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-141A>G Rv0010c_c.-141A>G 2 upstream_gene_variant 13699 NA 0 0 0 288 436 20558 27032 0.01381560011513 0.0122751663076303 0.0154937187991285 0.984126984126984 0.982578434101843 0.985571858692191 0.397790055248618 0.361926846488876 0.434489571269971 NA NA NA 0 0 0.00842504142309918 NA NA NA NA 4555 5574 False True 0.868566981223854 0.74501367531096 1.01143321715665 0 0 0.000179421563963251 0.984126984126984 0.982578434101843 0.985571858692191 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 185 317 13189 20996 0.0138328099297143 0.0119222920018979 0.0159589462877371 0.985126448646366 0.98341006602003 0.986708576567716 0.368525896414342 0.326212782276089 0.412397389521215 NA NA NA 0 0 0.0115693975119062 NA NA NA NA 3672 4479 False True 0 1 1 0 0 0 0 0.929045880648556 0.769713175726018 1.11879748170757 0 0 0.000279654532120739 0.985126448646366 0.98341006602003 0.986708576567716 164 5) Not assoc w R New NotAwR yes 5 +Isoniazid Rv0010c c.141G>A Rv0010c_c.141G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 10 20846 27458 0 0 0.00017694296670111 0.999635940002912 0.999330582956894 0.999825405716755 0 0 0.30849710781876 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.58772570736746 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 5 13374 21308 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.73894646374006 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.141G>C Rv0010c_c.141G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.141G>T Rv0010c_c.141G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.-143A>G Rv0010c_c.-143A>G 2 upstream_gene_variant 13701 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-145C>G Rv0010c_c.-145C>G 2 upstream_gene_variant 13703 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-145C>T Rv0010c_c.-145C>T 2 upstream_gene_variant 13703 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4545 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3663 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-146C>A Rv0010c_c.-146C>A 2 upstream_gene_variant 13704 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-146C>G Rv0010c_c.-146C>G 2 upstream_gene_variant 13704 1 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4459 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3584 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.147G>A Rv0010c_c.147G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.-147G>A Rv0010c_c.-147G>A 2 upstream_gene_variant 13705 1 18 1 17 2 21 20844 27447 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999235474006116 0.998831576963824 0.999526686034611 0.0869565217391304 0.0107099660378758 0.280379335909411 0.0555555555555555 0.00140555616736942 0.272943599673368 0.0454545454545454 0.00115014752657357 0.228444397667633 0.0774577533949676 0.0018576264171306 0.494441715667665 0.00114179072594574 80 5574 False False 0.1254077912109 0.0142262099872465 0.513147432883023 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 0.999235474006116 0.998831576963824 0.999526686034611 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 0 11 1 15 13373 21298 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999296204194623 0.998839461100611 0.999606039023746 0.0625 0.00158111172276588 0.302320738434531 0 0 0.284914152918154 0 0 0.218019360910534 0 0 0.63469947385726 0.00913122676867209 93 4479 False False 0 0 0 0 0 0 0 0.106174131957426 0.00252607251575667 0.690295349767496 0 0 0.000275807277411719 0.999296204194623 0.998839461100611 0.999606039023746 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-148C>T Rv0010c_c.-148C>T 2 upstream_gene_variant 13706 1 1 0 1 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 51.3428199661809 1 2027.5 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 62.0829055149378 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-149C>T Rv0010c_c.-149C>T 2 upstream_gene_variant 13707 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-14G>A Rv0010c_c.-14G>A 2 upstream_gene_variant 13572 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4531 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3650 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-150G>A Rv0010c_c.-150G>A 2 upstream_gene_variant 13708 1 0 0 0 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4452 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3576 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-153C>G Rv0010c_c.-153C>G 2 upstream_gene_variant 13711 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4490 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3609 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-153C>T Rv0010c_c.-153C>T 2 upstream_gene_variant 13711 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.15A>G Rv0010c_c.15A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.-15G>T Rv0010c_c.-15G>T 2 upstream_gene_variant 13573 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.162T>G Rv0010c_c.162T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.168C>T Rv0010c_c.168C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.-16A>G Rv0010c_c.-16A>G 2 upstream_gene_variant 13574 1 1 0 1 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 51.3446878573018 1 2027.5 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 62.0858160113928 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.177A>C Rv0010c_c.177A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.177A>G Rv0010c_c.177A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.-17G>A Rv0010c_c.-17G>A 2 upstream_gene_variant 13575 1 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4469 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3594 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.180G>A Rv0010c_c.180G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.181C>T Rv0010c_c.181C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.192C>A Rv0010c_c.192C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.18865318395302 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.85651838973546 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.192C>T Rv0010c_c.192C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.195C>A Rv0010c_c.195C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.195C>T Rv0010c_c.195C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.-19G>C Rv0010c_c.-19G>C 2 upstream_gene_variant 13577 1 2 0 2 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 7.01573328293188 0.509380354735251 864 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.48495357236853 0.526173219289417 690 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.1A>G Rv0010c_c.1A>G 2 initiator_codon_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.-1C>T Rv0010c_c.-1C>T 2 upstream_gene_variant 13559 1 0 0 0 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4444 5574 False False 0.439194051331254 0.00837049629364692 5.4704842261679 0 0 0.000176951454458875 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3569 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.201C>G Rv0010c_c.201C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.204G>A Rv0010c_c.204G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.207G>A Rv0010c_c.207G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.-20T>A Rv0010c_c.-20T>A 2 upstream_gene_variant 13578 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.213A>G Rv0010c_c.213A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.544526627735454 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.21G>A Rv0010c_c.21G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.-21G>A Rv0010c_c.-21G>A 2 upstream_gene_variant 13579 0 0 0 0 28 45 20818 27423 0.00134318334452652 0.000892715366584833 0.00194069331308385 0.998361730013106 0.997808473060249 0.998804791378681 0.383561643835616 0.27208638354562 0.504793771269344 NA NA NA 0 0 0.078705100406843 NA NA NA NA 4546 5574 False False 0.819636852723604 0.49219270495865 1.34332561861849 0 0 0.000177180932121844 0.998361730013106 0.997808473060249 0.998804791378681 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 28 44 13346 21269 0.00209361447584866 0.00139162853566266 0.00302444516059537 0.997935532304227 0.997229528416783 0.99849956619829 0.388888888888888 0.276154685847455 0.51106306377231 NA NA NA 0 0 0.0804199397635758 NA NA NA NA 3664 4479 False False 0 0 0 0 0 0 0 1.0141479231094 0.607677305049188 1.66677100318416 0 0 0.000276365179957634 0.997935532304227 0.997229528416783 0.99849956619829 5 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-21G>C Rv0010c_c.-21G>C 2 upstream_gene_variant 13579 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-21G>T Rv0010c_c.-21G>T 2 upstream_gene_variant 13579 1 4 0 4 4 4 20842 27464 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999854376001165 0.999627187086024 0.999960320981843 0.5 0.157012770487058 0.842987229512941 0 0 0.602364635616474 0 0 0.602364635616474 0 0 1.99643070207836 0.139137514901302 353 5574 False False 1.31772382688801 0.245404796089043 7.07564826366186 0 0 0.000176976922618654 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 3 2 13371 21311 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999906160559283 0.999661061221376 0.999988635406343 0.6 0.146632799634673 0.947255049473683 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.4872555868813 0.526202640597156 962.5 4479 False False 0 0 0 0 0 0 0 2.39073367736145 0.273835790357664 28.6284716983702 0 0 0.000275848526268708 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.222C>T Rv0010c_c.222C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.228G>C Rv0010c_c.228G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.-22G>A Rv0010c_c.-22G>A 2 upstream_gene_variant 13580 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4456 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3580 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-22G>C Rv0010c_c.-22G>C 2 upstream_gene_variant 13580 NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4429 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3554 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.232C>T Rv0010c_c.232C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.99604811372315 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.85651838973546 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.238C>A Rv0010c_c.238C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.240A>G Rv0010c_c.240A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.246C>G Rv0010c_c.246C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 8 7 20838 27461 0.000383766669864722 0.000165697303700768 0.000756032532322191 0.999745158002038 0.999474999027776 0.999897534357495 0.533333333333333 0.265861347277396 0.787333270480692 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.5060946348018 0.477150375804276 4.87970314895109 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 5 13371 21308 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999765401398207 0.999452610763328 0.999923822225278 0.375 0.0852334141372535 0.755136783633448 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.956158851245232 0.148446407940978 4.91535926753262 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.246C>T Rv0010c_c.246C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.249T>C Rv0010c_c.249T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 8 20846 27460 0 0 0.00017694296670111 0.99970875200233 0.999426206431739 0.999874251669172 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.771808536885009 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 7 13374 21306 0 0 0.000275786657608973 0.99967156195749 0.999323409938814 0.999867941002665 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.10552510564584 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.-24G>A Rv0010c_c.-24G>A 2 upstream_gene_variant 13582 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-24G>T Rv0010c_c.-24G>T 2 upstream_gene_variant 13582 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.24T>C Rv0010c_c.24T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.99604811372315 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.255G>A Rv0010c_c.255G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 8 20843 27460 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.99970875200233 0.999426206431739 0.999874251669172 0.272727272727272 0.0602177341729066 0.609742559572421 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.494050760447152 0.0844081742669313 2.05877344876832 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 5 13372 21308 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999765401398207 0.999452610763328 0.999923822225278 0.285714285714285 0.0366925661760855 0.709579136262657 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.637391564463057 0.0606680462541562 3.89402937569226 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.-25A>G Rv0010c_c.-25A>G 2 upstream_gene_variant 13583 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4445 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-25A>T Rv0010c_c.-25A>T 2 upstream_gene_variant 13583 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.261C>A Rv0010c_c.261C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.264A>G Rv0010c_c.264A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.276T>C Rv0010c_c.276T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.279C>A Rv0010c_c.279C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.18865318395302 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.85651838973546 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.279C>G Rv0010c_c.279C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 2 20844 27466 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999927188000582 0.999737003036386 0.999991182007438 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.3176933410094 0.0955278435529395 18.1762534351792 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 2 13372 21311 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999906160559283 0.999661061221376 0.999988635406343 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59370326054442 0.115491055908661 21.9865025501046 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.27C>A Rv0010c_c.27C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.-27G>A Rv0010c_c.-27G>A 2 upstream_gene_variant 13585 1 1 0 1 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 51.349017027227 1 2027.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3679 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-27G>C Rv0010c_c.-27G>C 2 upstream_gene_variant 13585 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-27G>T Rv0010c_c.-27G>T 2 upstream_gene_variant 13585 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.282T>C Rv0010c_c.282T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 38 220 20808 27248 0.00182289168185743 0.00129029962509865 0.00250121141611544 0.991990680064074 0.990864642034064 0.993010689176049 0.147286821705426 0.106384344265911 0.19651288722534 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.226185732760127 0.155829781656199 0.320427290516489 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 31 199 13343 21114 0.00231793031254673 0.00157544783409477 0.0032885173900642 0.990662975648665 0.989279154116057 0.991910363093251 0.134782608695652 0.0934493522344449 0.185827280234458 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 0 0.246504952251326 0.163023254771168 0.361441997660649 NA NA NA NA NA NA 29 5) Not assoc w R Now listed Silent mutation no 0 +Isoniazid Rv0010c c.285C>T Rv0010c_c.285C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.288C>T Rv0010c_c.288C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 4 20845 27464 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999854376001165 0.999627187086024 0.999960320981843 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.329383545214679 0.00669260119676484 3.32889360843958 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 4 13373 21309 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999812321118566 0.999519537882235 0.999948861529775 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.398358633066626 0.00809276091420046 4.02622197901862 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.291C>A Rv0010c_c.291C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.291C>G Rv0010c_c.291C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.300C>T Rv0010c_c.300C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 10 20842 27458 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999635940002912 0.999330582956894 0.999825405716755 0.285714285714285 0.0838893183071275 0.581035257183661 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.526974378658478 0.12062211620331 1.82733051585021 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 10 13373 21303 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999530802796415 0.99913729947772 0.999774979505452 0.0909090909090909 0.00229897221381426 0.412779916988382 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.159298586704553 0.00367454063771155 1.12000806973243 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.303G>A Rv0010c_c.303G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.99604811372315 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.41420404242617 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.309G>A Rv0010c_c.309G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.99604811372315 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.41420404242617 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.30C>T Rv0010c_c.30C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.43785249906968 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.41420404242617 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.318G>A Rv0010c_c.318G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.-31G>A Rv0010c_c.-31G>A 2 upstream_gene_variant 13589 1 6 0 6 4 6 20842 27462 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999781564001747 0.999524617886493 0.999919833755107 0.4 0.121552258119827 0.737621923393055 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.119223977151 0.0402234912969853 213.5 5574 False False 0.878418577871605 0.182308638457443 3.70497296035774 0 0 0.000176976922618654 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 13374 21307 0 0 0.000275786657608973 0.999718481677849 0.999387354605726 0.999896680954833 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.35335561005417 0.0884814409570568 164 4479 False False 0 0 0 0 0 0 0 0 0 1.35335561005417 0 0 0.000275786657608973 0.999718481677849 0.999387354605726 0.999896680954833 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.321C>A Rv0010c_c.321C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.327G>C Rv0010c_c.327G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 1 20842 27467 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999963594000291 0.999797175631493 0.999999078280314 0.8 0.28358206388191 0.994949236620532 NA NA NA NA NA NA NA NA NA NA NA NA False False 5.27147106803569 0.521589398427432 259.279173455301 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.327G>T Rv0010c_c.327G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 5 20845 27463 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999817970001456 0.999575254267103 0.999940892797913 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.263497241544735 0.00557522895465965 2.35509564487831 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 4 13373 21309 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999812321118566 0.999519537882235 0.999948861529775 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.398358633066626 0.00809276091420046 4.02622197901862 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.330G>A Rv0010c_c.330G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.439194051331254 0.00837049629364692 5.4704842261679 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.85651838973546 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.330G>T Rv0010c_c.330G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.247471899512553 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.333G>A Rv0010c_c.333G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.336G>A Rv0010c_c.336G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.339T>C Rv0010c_c.339T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.33G>C Rv0010c_c.33G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 16 20842 27452 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.99941750400466 0.999054234895718 0.999667017718464 0.2 0.0573339970500327 0.436614002996668 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.329287016601093 0.0801115836744329 1.02098825253189 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 4 15 13370 21298 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 0.999296204194623 0.998839461100611 0.999606039023746 0.210526315789473 0.0605245377092897 0.455653081891505 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.424791822488157 0.102596666143589 1.33378622153205 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.-34T>C Rv0010c_c.-34T>C 2 upstream_gene_variant 13592 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4437 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3562 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.357C>A Rv0010c_c.357C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.-35C>T Rv0010c_c.-35C>T 2 upstream_gene_variant 13593 NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4417 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3543 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.360C>T Rv0010c_c.360C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.363C>T Rv0010c_c.363C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.366C>T Rv0010c_c.366C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.375G>A Rv0010c_c.375G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.381C>T Rv0010c_c.381C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.439194051331254 0.00837049629364692 5.4704842261679 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 3 13373 21310 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999859240838924 0.999588697652472 0.999970971136275 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.531169769934445 0.010122018243966 6.61631049307563 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.384T>C Rv0010c_c.384T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 189 717 20657 26751 0.00906648757555406 0.00782462807836306 0.0104479977631493 0.973896898208824 0.971942272531762 0.975750387420473 0.208609271523178 0.182582214708059 0.236545946676393 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.341362193370377 0.288959065500528 0.401686167971111 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 166 677 13208 20636 0.0124121429639599 0.0106050223487527 0.0144357956313935 0.968235349317318 0.965792653507113 0.970549208762234 0.196915776986951 0.170575618826144 0.225393685726928 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 0 0.383096230117014 0.320840947674145 0.455312926145007 NA NA NA NA NA NA 27 5) Not assoc w R Now listed Silent mutation no 0 +Isoniazid Rv0010c c.387G>A Rv0010c_c.387G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.-38T>C Rv0010c_c.-38T>C 2 upstream_gene_variant 13596 1 0 0 0 5 19 20841 27449 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.999308286005533 0.998920012739518 0.999583493240977 0.208333333333333 0.0713186171980549 0.421512843637252 NA NA NA 0 0 0.176466911806965 NA NA NA NA 4526 5574 False False 0.346596662954348 0.101143506910399 0.959912718392501 0 0 0.000176985413634466 0.999308286005533 0.998920012739518 0.999583493240977 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 18 13373 21295 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999155445033547 0.998665566208554 0.999499388823668 0.0526315789473684 0.00133162880417942 0.260280654195214 NA NA NA 0 0 0.185301968137852 NA NA NA NA 3645 4479 False False 0 0 0 0 0 0 0 0.0884659803750508 0.00212733930226502 0.560429293726884 0 0 0.000275807277411719 0.999155445033547 0.998665566208554 0.999499388823668 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.393C>T Rv0010c_c.393C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.439194051331254 0.00837049629364692 5.4704842261679 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.396T>G Rv0010c_c.396T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.399C>G Rv0010c_c.399C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.3G>A Rv0010c_c.3G>A 2 initiator_codon_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.3G>C Rv0010c_c.3G>C 2 initiator_codon_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.3G>T Rv0010c_c.3G>T 2 initiator_codon_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.402T>G Rv0010c_c.402T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.408C>G Rv0010c_c.408C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.408C>T Rv0010c_c.408C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.414C>A Rv0010c_c.414C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.423G>A Rv0010c_c.423G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.43785249906968 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.41420404242617 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.425G>A Rv0010c_c.425G>A 2 stop_retained_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.-45C>G Rv0010c_c.-45C>G 2 upstream_gene_variant 13603 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-46T>G Rv0010c_c.-46T>G 2 upstream_gene_variant 13604 1 0 0 0 1 20 20845 27448 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999271880005825 0.998875700613314 0.999555190458412 0.0476190476190476 0.00120488344836351 0.238159909936821 NA NA NA 0 0 0.168433470983085 NA NA NA NA 4491 5574 False False 0.0658383305349004 0.00159270996657629 0.411717550396138 0 0 0.000176951454458875 0.999271880005825 0.998875700613314 0.999555190458412 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 14 13374 21299 0 0 0.000275786657608973 0.999343123914981 0.998898118907794 0.999640834680135 0 0 0.231635761650116 NA NA NA 0 0 0.231635761650116 NA NA NA NA 3610 4479 False False 0 0 0 0 0 0 0 0 0 0.480214320813834 0 0 0.000275786657608973 0.999343123914981 0.998898118907794 0.999640834680135 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-47G>A Rv0010c_c.-47G>A 2 upstream_gene_variant 13605 1 9 0 9 0 9 20846 27459 0 0 0.00017694296670111 0.999672346002621 0.99937810218515 0.999850165132458 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.667448724025835 0.0128622314815615 141.5 5574 False False 0 0 0.667448724025835 0 0 0.00017694296670111 0.999672346002621 0.99937810218515 0.999850165132458 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 13374 21307 0 0 0.000275786657608973 0.999718481677849 0.999387354605726 0.999896680954833 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.35335561005417 0.0884814409570568 164 4479 False False 0 0 0 0 0 0 0 0 0 1.35335561005417 0 0 0.000275786657608973 0.999718481677849 0.999387354605726 0.999896680954833 2 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-47G>C Rv0010c_c.-47G>C 2 upstream_gene_variant 13605 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4421 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-47G>T Rv0010c_c.-47G>T 2 upstream_gene_variant 13605 1 19 0 19 30 28 20816 27440 0.0014391250119927 0.000971175699964354 0.00205380828868033 0.998980632008154 0.998527063823414 0.999322533833553 0.517241379310344 0.382173719176468 0.650488796589153 0 0 0.176466911806965 0 0 0.123436118500263 0 0 0.28251778132342 2.50082885821315e-05 52 5574 True False 1.41237509607993 0.81513468871798 2.45419678369153 0 0 0.00017719795414655 0.998980632008154 0.998527063823414 0.999322533833553 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 17 0 17 15 23 13359 21290 0.00112157918349035 0.000627870944551516 0.00184920065907577 0.998920846431755 0.998381177107211 0.999315790080537 0.394736842105263 0.240387893644035 0.56613846139047 0 0 0.195064322969093 0 0 0.148185128915224 0 0 0.38627426815424 0.00053906533689332 48 4479 True False 0 0 0 0 0 0 0 1.03935793163377 0.504149920747812 2.08037360774658 0 0 0.000276096278743345 0.998920846431755 0.998381177107211 0.999315790080537 16 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-48C>T Rv0010c_c.-48C>T 2 upstream_gene_variant 13606 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-4A>C Rv0010c_c.-4A>C 2 upstream_gene_variant 13562 NA 0 0 0 5 0 20841 27468 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 1 0.999865711673152 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 4532 5574 False False Inf 1.20760984683633 Inf 0 0 0.000176985413634466 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3651 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 4 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-4A>G Rv0010c_c.-4A>G 2 upstream_gene_variant 13562 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-4A>T Rv0010c_c.-4A>T 2 upstream_gene_variant 13562 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4479 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3600 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-50_-49insA Rv0010c_c.-50_-49insA 2 upstream_gene_variant 13607 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-52A>G Rv0010c_c.-52A>G 2 upstream_gene_variant 13610 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.54C>T Rv0010c_c.54C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.57G>A Rv0010c_c.57G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 2 20844 27466 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999927188000582 0.999737003036386 0.999991182007438 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.3176933410094 0.0955278435529395 18.1762534351792 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.57G>T Rv0010c_c.57G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 9 20843 27459 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999672346002621 0.99937810218515 0.999850165132458 0.25 0.0548606445279927 0.571858461878189 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.439140238929136 0.0764596530706342 1.75996892947283 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 5 13374 21308 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.73894646374006 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.-58C>G Rv0010c_c.-58C>G 2 upstream_gene_variant 13616 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4422 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3547 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-58C>T Rv0010c_c.-58C>T 2 upstream_gene_variant 13616 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4522 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3640 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-5A>C Rv0010c_c.-5A>C 2 upstream_gene_variant 13563 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-5A>G Rv0010c_c.-5A>G 2 upstream_gene_variant 13563 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4551 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3668 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-60C>G Rv0010c_c.-60C>G 2 upstream_gene_variant 13618 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-61C>A Rv0010c_c.-61C>A 2 upstream_gene_variant 13619 1 5 1 4 1 5 20845 27463 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999817970001456 0.999575254267103 0.999940892797913 0.166666666666666 0.00421074451448947 0.641234578997674 0.2 0.00505076337946806 0.716417936118089 0.166666666666666 0.00421074451448947 0.641234578997674 0.329371551930918 0.00669235770498974 3.32877240593745 0.398231862372498 581 5574 False False 0.263497241544735 0.00557522895465965 2.35509564487831 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-62C>A Rv0010c_c.-62C>A 2 upstream_gene_variant 13620 1 17 0 17 1 25 20845 27443 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999089850007281 0.998656730244862 0.999410915028568 0.0384615384615384 0.00097328789333503 0.196369646762539 0 0 0.195064322969093 0 0 0.137185171530712 0 0 0.319103275765169 8.20250869761371e-05 59 5574 True False 0.0526610698009114 0.00128691236011034 0.321741107473799 0 0 0.000176951454458875 0.999089850007281 0.998656730244862 0.999410915028568 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 17 0 17 1 25 13373 21288 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.998827006991038 0.998268914575298 0.99924076142744 0.0384615384615384 0.00097328789333503 0.196369646762539 0 0 0.195064322969093 0 0 0.137185171530712 0 0 0.385833409906209 0.000286757327464057 41 4479 True False 0 0 0 0 0 0 0 0.0636745681597248 0.00155499962861658 0.38908921072594 0 0 0.000275807277411719 0.998827006991038 0.998268914575298 0.99924076142744 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.63C>A Rv0010c_c.63C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 11 0 20835 27468 0.000527679171063993 0.000263444034397523 0.000943967185544106 1 0.999865711673152 1 1 0.715085847081845 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 3.30816067473776 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 11 0 13363 21313 0.000822491401226259 0.000410653977896139 0.00147118664271154 1 0.999826933785262 1 1 0.715085847081845 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 4.00162721599209 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.-63C>T Rv0010c_c.-63C>T 2 upstream_gene_variant 13621 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-64_-63insTCAT Rv0010c_c.-64_-63insTCAT 2 upstream_gene_variant 13621 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-65_-64insGTGATTCA Rv0010c_c.-65_-64insGTGATTCA 2 upstream_gene_variant 13622 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4470 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3595 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-65A>G Rv0010c_c.-65A>G 2 upstream_gene_variant 13623 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4464 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3589 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-66C>A Rv0010c_c.-66C>A 2 upstream_gene_variant 13624 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-66C>G Rv0010c_c.-66C>G 2 upstream_gene_variant 13624 1 2 0 2 3 5 20843 27463 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999817970001456 0.999575254267103 0.999940892797913 0.375 0.0852334141372535 0.755136783633448 0 0 0.841886116991581 0 0 0.521823750104981 0 0 7.01623216775426 0.509385135151685 1117 5574 False False 0.790567576644437 0.122780413850952 4.06394022809159 0 0 0.00017696843241753 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 2 5 13372 21308 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999765401398207 0.999452610763328 0.999923822225278 0.285714285714285 0.0366925661760855 0.709579136262657 0 0 0.841886116991581 0 0 0.521823750104981 0 0 8.48542627113303 0.526179258690734 900 4479 False False 0 0 0 0 0 0 0 0.637391564463057 0.0606680462541562 3.89402937569226 0 0 0.000275827900298067 0.999765401398207 0.999452610763328 0.999923822225278 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-66C>T Rv0010c_c.-66C>T 2 upstream_gene_variant 13624 1 26 0 26 56 33 20790 27435 0.00268636668905305 0.00202987113537781 0.00348707100741373 0.998798602009611 0.998313200429948 0.999172873081023 0.629213483146067 0.520298113467579 0.729270066365685 0 0 0.132274604497754 0 0 0.105762810074579 0 0 0.20121859075026 6.16001159610134e-07 31 5574 True False 2.23936333027242 1.43069037675075 3.55602151880935 0 0 0.00017741953847001 0.998798602009611 0.998313200429948 0.999172873081023 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 23 0 23 56 30 13318 21283 0.00418722895169732 0.00316449143546909 0.00543406401984753 0.998592408389246 0.997991180201286 0.999050108601822 0.651162790697674 0.540772239780411 0.750813354779753 0 0 0.148185128915224 0 0 0.115703308222027 0 0 0.278074704254205 1.63104359919313e-05 31 4479 True False 0 0 0 0 0 0 0 2.98305050808429 1.88065270638696 4.81785866382814 0 0 0.000276946134560744 0.998592408389246 0.997991180201286 0.999050108601822 2 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.66G>C Rv0010c_c.66G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.-67T>C Rv0010c_c.-67T>C 2 upstream_gene_variant 13625 1 10 0 10 6 12 20840 27456 0.000287825002398541 0.000105633792978048 0.000626367784710498 0.999563128003495 0.99923699702714 0.999774242139628 0.333333333333333 0.133427402506123 0.590074761827925 0 0 0.30849710781876 0 0 0.264648469397051 0 0 0.587852153162306 0.00669309950448756 113 5574 False False 0.65873320537428 0.202834119084116 1.89684355523546 0 0 0.000176993905465082 0.999563128003495 0.99923699702714 0.999774242139628 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 3 8 13371 21305 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999624642237132 0.999260530264256 0.999837933676441 0.272727272727272 0.0602177341729066 0.609742559572421 0 0 0.409616397225003 0 0 0.369416647552819 0 0 1.10572126682866 0.048445423807518 137 4479 False False 0 0 0 0 0 0 0 0.597515144716176 0.102061600869156 2.49011680409225 0 0 0.000275848526268708 0.999624642237132 0.999260530264256 0.999837933676441 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-68T>C Rv0010c_c.-68T>C 2 upstream_gene_variant 13626 1 4 0 4 1 5 20845 27463 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999817970001456 0.999575254267103 0.999940892797913 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.602364635616474 0 0 0.521823750104981 0 0 1.9960711666997 0.139119205469767 335 5574 False False 0.263497241544735 0.00557522895465965 2.35509564487831 0 0 0.000176951454458875 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 1 5 13373 21308 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999765401398207 0.999452610763328 0.999923822225278 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.602364635616474 0 0 0.521823750104981 0 0 2.41427134641658 0.305472044773727 432 4479 False False 0 0 0 0 0 0 0 0.318671950945935 0.00674139558547252 2.84834809554519 0 0 0.000275807277411719 0.999765401398207 0.999452610763328 0.999923822225278 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-68T>G Rv0010c_c.-68T>G 2 upstream_gene_variant 13626 1 2 0 2 4 3 20842 27465 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999890782000873 0.99968085216583 0.999977476056514 0.571428571428571 0.184051567640083 0.901011721557492 0 0 0.841886116991581 0 0 0.707598226178713 0 0 7.01707977037795 0.509393260941204 1185 5574 False False 1.75702907590442 0.297192930207644 11.9979296337129 0 0 0.000176976922618654 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 2 13372 21311 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999906160559283 0.999661061221376 0.999988635406343 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 62.0980038756619 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59370326054442 0.115491055908661 21.9865025501046 0 0 0.000275827900298067 0.999906160559283 0.999661061221376 0.999988635406343 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-69A>C Rv0010c_c.-69A>C 2 upstream_gene_variant 13627 1 2 0 2 5 4 20841 27464 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.999854376001165 0.999627187086024 0.999960320981843 0.555555555555555 0.212008506778868 0.863004337734833 0 0 0.841886116991581 0 0 0.602364635616474 0 0 7.01716098232863 0.509394039190978 1187 5574 False False 1.64723381795499 0.354499279020611 8.30243796120459 0 0 0.000176985413634466 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 5 3 13369 21310 0.000373859727830118 0.000121402023062639 0.000872246401868143 0.999859240838924 0.999588697652472 0.999970971136275 0.625 0.244863216366551 0.914766585862746 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.48812702402024 0.526213778991498 968.5 4479 False False 0 0 0 0 0 0 0 2.65664347869449 0.516758123120163 17.1115025092299 0 0 0.000275889787465637 0.999859240838924 0.999588697652472 0.999970971136275 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-69A>G Rv0010c_c.-69A>G 2 upstream_gene_variant 13627 1 10 0 10 27 14 20819 27454 0.00129521251079343 0.000853721301750774 0.00188391092655412 0.999490316004077 0.999144984581285 0.999721323894632 0.658536585365853 0.494052526394266 0.799165886282918 0 0 0.30849710781876 0 0 0.231635761650116 0 0 0.588402476745708 0.0066933122101709 117 5574 False False 2.54320572553917 1.28729457532288 5.2482455245055 0 0 0.000177172422335812 0.999490316004077 0.999144984581285 0.999721323894632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 15 11 13359 21302 0.00112157918349035 0.000627870944551516 0.00184920065907577 0.999483883076056 0.999076712346733 0.999742329032819 0.576923076923076 0.369180380923966 0.766478016872556 0 0 0.336267116879942 0 0 0.284914152918154 0 0 0.808032447763996 0.015391157225115 106 4479 False False 0 0 0 0 0 0 0 2.17442786272788 0.932867366036034 5.23581963428355 0 0 0.000276096278743345 0.999483883076056 0.999076712346733 0.999742329032819 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.6G>A Rv0010c_c.6G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.-6G>A Rv0010c_c.-6G>A 2 upstream_gene_variant 13564 1 1 0 1 1 5 20845 27463 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999817970001456 0.999575254267103 0.999940892797913 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.975 0 0 0.521823750104981 0 0 51.3434130854697 1 2027.5 5574 False False 0.263497241544735 0.00557522895465965 2.35509564487831 0 0 0.000176951454458875 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 5 13373 21308 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999765401398207 0.999452610763328 0.999923822225278 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.975 0 0 0.521823750104981 0 0 62.0846327040722 1 1642.5 4479 False False 0 0 0 0 0 0 0 0.318671950945935 0.00674139558547252 2.84834809554519 0 0 0.000275807277411719 0.999765401398207 0.999452610763328 0.999923822225278 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-6G>C Rv0010c_c.-6G>C 2 upstream_gene_variant 13564 NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4438 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3563 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-71delT Rv0010c_c.-71delT 2 upstream_gene_variant 13628 NA 0 0 0 14 0 20832 27468 0.000671591672263264 0.000367212509754494 0.00112656023057506 1 0.999865711673152 1 1 0.768364238349883 1 NA NA NA NA NA NA NA NA NA NA 4460 5574 False False Inf 4.37287801662981 Inf 0 0 0.000177061869457058 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 6 0 13368 21313 0.000448631673396141 0.000164657143425453 0.000976224581517196 1 0.999826933785262 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 3585 4479 False False 0 0 0 0 0 0 0 Inf 1.87681913692541 Inf 0 0 0.00027591042269331 1 0.999826933785262 1 2 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-71T>C Rv0010c_c.-71T>C 2 upstream_gene_variant 13629 1 19 1 18 38 22 20808 27446 0.00182289168185743 0.00129029962509865 0.00250121141611544 0.999199068006407 0.998787628960307 0.999497994263003 0.633333333333333 0.498969282356292 0.754059389562713 0.0526315789473684 0.00133162880417942 0.260280654195214 0.0434782608695652 0.0011001686304415 0.21948660745348 0.0732784399162715 0.00176299737834131 0.464190358168827 0.000630749407378409 72 5574 True False 2.27829331376044 1.31310099048116 4.04539721387628 4.80561295593252e-05 1.21667512050138e-06 0.000267722206594373 0.999199068006407 0.998787628960307 0.999497994263003 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 13 0 13 23 17 13351 21296 0.00171975474801853 0.00109047959787275 0.00257936584619975 0.999202364753906 0.998723214865585 0.999535281595187 0.575 0.408900580426963 0.729570968731137 0 0 0.24705263800047 0 0 0.195064322969093 0 0 0.523486118825012 0.00269470793447963 63 4479 False False 0 0 0 0 0 0 0 2.15805821991743 1.10290931740906 4.30489294162487 0 0 0.000276261694450225 0.999202364753906 0.998723214865585 0.999535281595187 2 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-71T>G Rv0010c_c.-71T>G 2 upstream_gene_variant 13629 1 3 1 2 21 2 20825 27466 0.00100738750839489 0.000623693493785757 0.00153948878572471 0.999927188000582 0.999737003036386 0.999991182007438 0.913043478260869 0.719620664090589 0.989290033962124 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.659447779111644 0.0111825785582155 12.6688946847463 1 2027.5 5574 False False 13.8484033613445 3.38431562318143 121.985874324116 4.80169019494862e-05 1.21568196461564e-06 0.000267503692334282 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 11 2 13363 21311 0.000822491401226259 0.000410653977896139 0.00147118664271154 0.999906160559283 0.999661061221376 0.999988635406343 0.846153846153846 0.545528944323442 0.980793328017471 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.797388311008007 0.0135200743804508 15.3190129893923 1 1642.5 4479 False False 0 0 0 0 0 0 0 8.77127142108807 1.91382626509507 81.6341774283486 7.4827895839569e-05 1.89447650421177e-06 0.000416843047927529 0.999906160559283 0.999661061221376 0.999988635406343 9 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-72delG Rv0010c_c.-72delG 2 upstream_gene_variant 13629 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-72G>A Rv0010c_c.-72G>A 2 upstream_gene_variant 13630 1 19 2 17 30 18 20816 27450 0.0014391250119927 0.000971175699964354 0.00205380828868033 0.999344692005242 0.998964527817385 0.999611578174657 0.625 0.473505760646776 0.760477596543414 0.105263157894736 0.0130121643717774 0.331376664456765 0.1 0.0123485271702948 0.316982714019082 0.155140841886331 0.0174069803165649 0.653694913889877 0.00414117356345595 107 5574 False False 2.1978285933897 1.18559461387753 4.18816957668394 9.60707080411182e-05 1.16348202034841e-05 0.000346996884217535 0.999344692005242 0.998964527817385 0.999611578174657 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 12 2 10 22 11 13352 21302 0.00164498280245251 0.00103118012105387 0.00248947070088324 0.999483883076056 0.999076712346733 0.999742329032819 0.666666666666666 0.481732527512417 0.820394865067439 0.166666666666666 0.0208625254600923 0.484137748685967 0.153846153846153 0.0192066719825284 0.454471055676557 0.319083283403235 0.0339834103560327 1.49769514151104 0.146150948861268 195 4479 False False 0 0 0 0 0 0 0 3.19083283403235 1.48239773276121 7.29080443076364 0.000149767859817283 1.81380972863362e-05 0.000540907180910465 0.999483883076056 0.999076712346733 0.999742329032819 3 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-72G>C Rv0010c_c.-72G>C 2 upstream_gene_variant 13630 1 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4492 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3611 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-72G>T Rv0010c_c.-72G>T 2 upstream_gene_variant 13630 1 1 0 1 2 2 20844 27466 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999927188000582 0.999737003036386 0.999991182007438 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 51.3514785421127 1 2027.5 5574 False False 1.3176933410094 0.0955278435529395 18.1762534351792 0 0 0.000176959943030976 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 62.0933648450895 1 1642.5 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-73_-70delTGTG Rv0010c_c.-73_-70delTGTG 2 upstream_gene_variant 13627 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4499 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3618 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-73T>C Rv0010c_c.-73T>C 2 upstream_gene_variant 13631 1 5 2 3 20 7 20826 27461 0.000959416674661805 0.000586132014909014 0.00148135424594851 0.999745158002038 0.999474999027776 0.999897534357495 0.74074074074074 0.537151257723828 0.888855437154557 0.4 0.0527449505263169 0.853367200365326 0.222222222222222 0.0281449734778982 0.600093573716312 0.879061429623227 0.0733882161907956 7.67515015644294 1 2027.5 5574 False False 3.76740612695668 1.52986605589243 10.5438315213217 9.6024582293067e-05 1.16292339581074e-05 0.000346830303959103 0.999745158002038 0.999474999027776 0.999897534357495 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 2 3 13 7 13361 21306 0.000972035292358307 0.000517666151348512 0.00166163634851859 0.99967156195749 0.999323409938814 0.999867941002665 0.65 0.407811465467171 0.846090795215458 0.4 0.0527449505263169 0.853367200365326 0.222222222222222 0.0281449734778982 0.600093573716312 1.06309407978444 0.0887549087559116 9.2830486158613 1 1642.5 4479 False False 0 0 0 0 0 0 0 2.96147636511381 1.09778256922402 8.76804344099539 0.000149666990945147 1.81258809049439e-05 0.000540542950352468 0.99967156195749 0.999323409938814 0.999867941002665 3 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-73T>G Rv0010c_c.-73T>G 2 upstream_gene_variant 13631 1 1 0 1 3 5 20843 27463 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999817970001456 0.999575254267103 0.999940892797913 0.375 0.0852334141372535 0.755136783633448 0 0 0.975 0 0 0.521823750104981 0 0 51.3483358143814 1 2027.5 5574 False False 0.790567576644437 0.122780413850952 4.06394022809159 0 0 0.00017696843241753 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 5 13373 21308 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999765401398207 0.999452610763328 0.999923822225278 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.975 0 0 0.521823750104981 0 0 62.0846327040722 1 1642.5 4479 False False 0 0 0 0 0 0 0 0.318671950945935 0.00674139558547252 2.84834809554519 0 0 0.000275807277411719 0.999765401398207 0.999452610763328 0.999923822225278 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-74A>C Rv0010c_c.-74A>C 2 upstream_gene_variant 13632 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4480 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3601 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-75C>A Rv0010c_c.-75C>A 2 upstream_gene_variant 13633 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-75C>G Rv0010c_c.-75C>G 2 upstream_gene_variant 13633 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4493 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-75C>T Rv0010c_c.-75C>T 2 upstream_gene_variant 13633 1 5 0 5 2 7 20844 27461 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999745158002038 0.999474999027776 0.999897534357495 0.222222222222222 0.0281449734778982 0.600093573716312 0 0 0.521823750104981 0 0 0.409616397225003 0 0 1.43788585526564 0.0743400529649486 265 5574 False False 0.376415275379005 0.0381509889597215 1.97729867984898 0 0 0.000176959943030976 0.999745158002038 0.999474999027776 0.999897534357495 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 4 13373 21309 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999812321118566 0.999519537882235 0.999948861529775 0.2 0.00505076337946806 0.716417936118089 0 0 0.841886116991581 0 0 0.602364635616474 0 0 8.48518990407669 0.526176238728858 704.5 4479 False False 0 0 0 0 0 0 0 0.398358633066626 0.00809276091420046 4.02622197901862 0 0 0.000275807277411719 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.75T>C Rv0010c_c.75T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 7 2 20839 27466 0.000335795836131632 0.000135017659185429 0.000691744589626827 0.999927188000582 0.999737003036386 0.999991182007438 0.777777777777777 0.399906426283687 0.971855026522101 NA NA NA NA NA NA NA NA NA NA NA NA False False 4.61303325495465 0.87817476276209 45.5132476135674 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 5 2 13369 21311 0.000373859727830118 0.000121402023062639 0.000872246401868143 0.999906160559283 0.999661061221376 0.999988635406343 0.714285714285714 0.290420863737342 0.963307433823914 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.98515221781733 0.652287032938702 41.8973624237223 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.-76G>A Rv0010c_c.-76G>A 2 upstream_gene_variant 13634 NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4515 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3632 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-76G>T Rv0010c_c.-76G>T 2 upstream_gene_variant 13634 1 6 0 6 1 10 20845 27458 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999635940002912 0.999330582956894 0.999825405716755 0.0909090909090909 0.00229897221381426 0.412779916988382 0 0 0.4592581264399 0 0 0.30849710781876 0 0 1.11889992439267 0.0402045481045069 181.5 5574 False False 0.131724634204845 0.00303942055735959 0.926075505001071 0 0 0.000176951454458875 0.999635940002912 0.999330582956894 0.999825405716755 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 10 13374 21303 0 0 0.000275786657608973 0.999530802796415 0.99913729947772 0.999774979505452 0 0 0.30849710781876 0 0 0.4592581264399 0 0 0.30849710781876 0 0 1.35310166397741 0.0884761941542541 152.5 4479 False False 0 0 0 0 0 0 0 0 0 0.710765762832934 0 0 0.000275786657608973 0.999530802796415 0.99913729947772 0.999774979505452 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-77C>G Rv0010c_c.-77C>G 2 upstream_gene_variant 13635 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4562 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3676 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-78A>C Rv0010c_c.-78A>C 2 upstream_gene_variant 13636 1 3 0 3 15 4 20831 27464 0.000719562505996354 0.000402787826414311 0.00118653165660568 0.999854376001165 0.999627187086024 0.999960320981843 0.789473684210526 0.544346918108494 0.93947546229071 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.19083326383285 0.264143214639985 575 5574 False False 4.94407373625846 1.57469812694187 20.4593815730792 0 0 0.000177070368626196 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 9 2 13365 21311 0.000672947510094212 0.000307759154923187 0.00127707788784856 0.999906160559283 0.999661061221376 0.999988635406343 0.818181818181818 0.482244147639827 0.97716880170004 0 0 0.975 0 0 0.841886116991581 0 0 62.1304965085621 1 1642.5 4479 False False 0 0 0 0 0 0 0 7.17542087542087 1.48477409322259 68.3572890372157 0 0 0.000275972346901473 0.999906160559283 0.999661061221376 0.999988635406343 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-78A>G Rv0010c_c.-78A>G 2 upstream_gene_variant 13636 1 16 0 16 57 27 20789 27441 0.00273433752278614 0.00207159836008266 0.00354121907298974 0.999017038007863 0.998570161716172 0.99935212504807 0.678571428571428 0.567757520199671 0.776373779604866 0 0 0.205907214207822 0 0 0.127702867615432 0 0 0.342324428181762 0.00015202899748371 64 5574 True False 2.78661792294001 1.73305234729161 4.58391421078548 0 0 0.000177428072011687 0.999017038007863 0.998570161716172 0.99935212504807 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 35 20 13339 21293 0.00261701809481082 0.00182350527060428 0.00363777714536766 0.99906160559283 0.998551096167295 0.999426713067202 0.636363636363636 0.495631454911986 0.761861620786517 0 0 0.30849710781876 0 0 0.168433470983085 0 0 0.712296031973247 0.00894139397579591 83 4479 False False 0 0 0 0 0 0 0 2.79351900442312 1.56782120088349 5.10977054063252 0 0 0.000276510189986331 0.99906160559283 0.998551096167295 0.999426713067202 5 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-78A>T Rv0010c_c.-78A>T 2 upstream_gene_variant 13636 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.78G>A Rv0010c_c.78G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 7 20846 27461 0 0 0.00017694296670111 0.999745158002038 0.999474999027776 0.999897534357495 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.914121240039481 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.85651838973546 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.78G>T Rv0010c_c.78G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.-79C>A Rv0010c_c.-79C>A 2 upstream_gene_variant 13637 1 1 0 1 8 1 20838 27467 0.000383766669864722 0.000165697303700768 0.000756032532322191 0.999963594000291 0.999797175631493 0.999999078280314 0.888888888888888 0.517503485082663 0.9971908632534 0 0 0.975 0 0 0.975 0 0 51.3681211956089 1 2027.5 5574 False False 10.5449659276322 1.4135292589455 466.907166500354 0 0 0.000177010891571197 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 5 0 13369 21313 0.000373859727830118 0.000121402023062639 0.000872246401868143 1 0.999826933785262 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 3612 4479 False False 0 0 0 0 0 0 0 Inf 1.46057233596553 Inf 0 0 0.000275889787465637 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-79C>G Rv0010c_c.-79C>G 2 upstream_gene_variant 13637 NA 0 0 0 6 0 20840 27468 0.000287825002398541 0.000105633792978048 0.000626367784710498 1 0.999865711673152 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 4538 5574 False False Inf 1.55167078958407 Inf 0 0 0.000176993905465082 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3657 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-79C>T Rv0010c_c.-79C>T 2 upstream_gene_variant 13637 1 4 0 4 19 11 20827 27457 0.000911445840928715 0.000548836318218138 0.00142297127227785 0.999599534003203 0.9992835689522 0.999800072407065 0.633333333333333 0.438559849011957 0.800701374987965 0 0 0.602364635616474 0 0 0.284914152918154 0 0 1.99735821021174 0.139184782379464 362 5574 False False 2.27712715574625 1.0295099219544 5.29771690765872 0 0 0.000177104373463711 0.999599534003203 0.9992835689522 0.999800072407065 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 18 5 13356 21308 0.00134589502018842 0.000797851614369596 0.00212626349435784 0.999765401398207 0.999452610763328 0.999923822225278 0.782608695652174 0.562969273763185 0.925396592351196 0 0 0.841886116991581 0 0 0.521823750104981 0 0 8.49559176727199 0.52630923426955 983 4479 False False 0 0 0 0 0 0 0 5.74339622641509 2.05433120212571 19.7923938369317 0 0 0.000276158286414525 0.999765401398207 0.999452610763328 0.999923822225278 2 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-7G>A Rv0010c_c.-7G>A 2 upstream_gene_variant 13565 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4533 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3652 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-7G>T Rv0010c_c.-7G>T 2 upstream_gene_variant 13565 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-80_-79insA Rv0010c_c.-80_-79insA 2 upstream_gene_variant 13637 1 2 0 2 3 2 20843 27466 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999927188000582 0.999737003036386 0.999991182007438 0.6 0.146632799634673 0.947255049473683 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01699856622015 0.509392482788101 1176.5 5574 False False 1.97663484143357 0.226402568392661 23.6672561646805 0 0 0.00017696843241753 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 2 2 13372 21311 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999906160559283 0.999661061221376 0.999988635406343 0.5 0.067585986488543 0.932414013511457 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.4866208667913 0.526194527956412 951.5 4479 False False 0 0 0 0 0 0 0 1.59370326054442 0.115491055908661 21.9865025501046 0 0 0.000275827900298067 0.999906160559283 0.999661061221376 0.999988635406343 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-80A>C Rv0010c_c.-80A>C 2 upstream_gene_variant 13638 1 6 1 5 9 6 20837 27462 0.000431737503597812 0.000197436276106449 0.000819413341228355 0.999781564001747 0.999524617886493 0.999919833755107 0.6 0.322869766206281 0.836635676140486 0.166666666666666 0.00421074451448947 0.641234578997674 0.142857142857142 0.00361029686190058 0.578723197043195 0.263588808369726 0.00557716446908151 2.35591410333829 0.245038673304781 417 5574 False False 1.97691606277295 0.62829607236878 6.75185361955151 4.79892504079086e-05 1.21498188904634e-06 0.000267349661612127 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 4 2 13370 21311 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 0.999906160559283 0.999661061221376 0.999988635406343 0.666666666666666 0.222778095503512 0.956728131707258 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48789040192002 0.526210754961348 965.5 4479 False False 0 0 0 0 0 0 0 3.18788332086761 0.456775580099959 35.246992707007 0 0 0.000275869155324334 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-80A>G Rv0010c_c.-80A>G 2 upstream_gene_variant 13638 1 16 1 15 16 26 20830 27442 0.000767533339729444 0.000438773245501675 0.00124612759964746 0.999053444007572 0.998613381560132 0.999381587946625 0.380952380952381 0.235720546863216 0.543632504502101 0.0625 0.00158111172276588 0.302320738434531 0.037037037037037 0.000937257091944708 0.189705617413044 0.0878284525524083 0.00209048418292485 0.57097760919119 0.0018977121186079 90 5574 False False 0.810724177406846 0.406221452138612 1.56985986434344 4.80053766021794e-05 1.21539016844027e-06 0.000267439491302368 0.999053444007572 0.998613381560132 0.999381587946625 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 10 16 13364 21297 0.000747719455660236 0.000358616922835118 0.00137465137870696 0.999249284474264 0.998781170540482 0.999570842259671 0.384615384615384 0.20226024365502 0.594292464701408 0 0 0.409616397225003 0 0 0.205907214207822 0 0 1.10588511240365 0.0484509319358935 138 4479 False False 0 0 0 0 0 0 0 0.996006061059563 0.403927387745582 2.33516144315228 0 0 0.000275992994481552 0.999249284474264 0.998781170540482 0.999570842259671 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-81C>G Rv0010c_c.-81C>G 2 upstream_gene_variant 13639 1 20 0 20 0 21 20846 27447 0 0 0.00017694296670111 0.999235474006116 0.998831576963824 0.999526686034611 0 0 0.161097615219079 0 0 0.168433470983085 0 0 0.161097615219079 0 0 0.266725714062677 1.37688359223306e-05 46.5 5574 True False 0 0 0.252885886770404 0 0 0.00017694296670111 0.999235474006116 0.998831576963824 0.999526686034611 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 8 13374 21305 0 0 0.000275786657608973 0.999624642237132 0.999260530264256 0.999837933676441 0 0 0.369416647552819 0 0 0.409616397225003 0 0 0.369416647552819 0 0 1.10547322569492 0.0484370885852277 126 4479 False False 0 0 0 0 0 0 0 0 0 0.93343997011793 0 0 0.000275786657608973 0.999624642237132 0.999260530264256 0.999837933676441 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-82T>A Rv0010c_c.-82T>A 2 upstream_gene_variant 13640 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4430 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3555 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-82T>C Rv0010c_c.-82T>C 2 upstream_gene_variant 13640 1 8 2 6 11 9 20835 27459 0.000527679171063993 0.000263444034397523 0.000943967185544106 0.999672346002621 0.99937810218515 0.999850165132458 0.55 0.315278133040548 0.769422103224075 0.25 0.0318540262499442 0.650855794412824 0.181818181818181 0.0228311982999596 0.517755852360172 0.439308855291576 0.0433600148148708 2.45698627699948 0.479323882891923 832 5574 False False 1.61079913606911 0.606726538712421 4.39856275487397 9.59831069731727e-05 1.1624210921735e-05 0.00034668051841439 0.999672346002621 0.99937810218515 0.999850165132458 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 2 4 9 6 13365 21307 0.000672947510094212 0.000307759154923187 0.00127707788784856 0.999718481677849 0.999387354605726 0.999896680954833 0.6 0.322869766206281 0.836635676140486 0.333333333333333 0.0432718682927417 0.777221904496487 0.25 0.0318540262499442 0.650855794412824 0.797119341563786 0.0720785329754175 5.56316891865074 1 1642.5 4479 False False 0 0 0 0 0 0 0 2.39135802469135 0.759931796465188 8.16620012830298 0.000149622203935063 1.81204566826848e-05 0.000540381227509415 0.999718481677849 0.999387354605726 0.999896680954833 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-82T>G Rv0010c_c.-82T>G 2 upstream_gene_variant 13640 1 5 0 5 1 7 20845 27461 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999745158002038 0.999474999027776 0.999897534357495 0.125 0.0031597235312519 0.526509670875206 0 0 0.521823750104981 0 0 0.409616397225003 0 0 1.43781666391196 0.0743359452141025 238.5 5574 False False 0.188198608779083 0.00417990056987037 1.46513319151887 0 0 0.000176951454458875 0.999745158002038 0.999474999027776 0.999897534357495 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.85633740727807 0.289259828934126 294 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-83A>C Rv0010c_c.-83A>C 2 upstream_gene_variant 13641 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-83A>G Rv0010c_c.-83A>G 2 upstream_gene_variant 13641 1 2 0 2 7 2 20839 27466 0.000335795836131632 0.000135017659185429 0.000691744589626827 0.999927188000582 0.999737003036386 0.999991182007438 0.777777777777777 0.399906426283687 0.971855026522101 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01834549037735 0.509405398863652 1204.5 5574 False False 4.61303325495465 0.87817476276209 45.5132476135674 0 0 0.00017700239811062 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 5 2 13369 21311 0.000373859727830118 0.000121402023062639 0.000872246401868143 0.999906160559283 0.999661061221376 0.999988635406343 0.714285714285714 0.290420863737342 0.963307433823914 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48852531192879 0.526218871049245 973 4479 False False 0 0 0 0 0 0 0 3.98515221781733 0.652287032938702 41.8973624237223 0 0 0.000275889787465637 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-83A>T Rv0010c_c.-83A>T 2 upstream_gene_variant 13641 1 1 0 1 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 51.349017027227 1 2027.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 62.0933648450895 1 1642.5 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-84A>C Rv0010c_c.-84A>C 2 upstream_gene_variant 13642 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4483 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-84A>G Rv0010c_c.-84A>G 2 upstream_gene_variant 13642 1 1 0 1 3 2 20843 27466 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999927188000582 0.999737003036386 0.999991182007438 0.6 0.146632799634673 0.947255049473683 0 0 0.975 0 0 0.841886116991581 0 0 51.3539402930048 1 2027.5 5574 False False 1.97663484143357 0.226402568392661 23.6672561646805 0 0 0.00017696843241753 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 3 1 13371 21312 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999953080279641 0.999738608085756 0.999998812096234 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 3613 4479 False False 0 0 0 0 0 0 0 4.78169172088849 0.383875689805931 250.696170545132 0 0 0.000275848526268708 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-84A>T Rv0010c_c.-84A>T 2 upstream_gene_variant 13642 1 0 0 0 19 2 20827 27466 0.000911445840928715 0.000548836318218138 0.00142297127227785 0.999927188000582 0.999737003036386 0.999991182007438 0.904761904761904 0.696225593086075 0.988250682115554 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4423 5574 False False 12.5283046045997 3.02173590603041 111.007605235237 0 0 0.000177104373463711 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 16 2 13358 21311 0.00119635112905637 0.00068396778211822 0.00194207416051199 0.999906160559283 0.999661061221376 0.999988635406343 0.888888888888888 0.652879561391328 0.986248784335635 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3548 4479 False False 0 0 0 0 0 0 0 12.762988471328 2.99970947792407 114.525975765494 0 0 0.00027611694487284 0.999906160559283 0.999661061221376 0.999988635406343 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-85C>G Rv0010c_c.-85C>G 2 upstream_gene_variant 13643 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-86_-75delTCAATCACACGC Rv0010c_c.-86_-75delTCAATCACACGC 2 upstream_gene_variant 13632 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4410 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-86_-81delTCAATC Rv0010c_c.-86_-81delTCAATC 2 upstream_gene_variant 13638 NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4406 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-86_-85insT Rv0010c_c.-86_-85insT 2 upstream_gene_variant 13643 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.87C>A Rv0010c_c.87C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.-87C>T Rv0010c_c.-87C>T 2 upstream_gene_variant 13645 1 1 1 0 2 3 20844 27465 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999890782000873 0.99968085216583 0.999977476056514 0.4 0.0527449505263169 0.853367200365326 1 0.025 1 0.25 0.00630946320970987 0.805879550316756 Inf 0.0337838879367385 Inf 0.431484164769199 827.5 5574 False False 0.878430243715217 0.0733354884838472 7.66963698207431 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 2 13372 21311 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999906160559283 0.999661061221376 0.999988635406343 0.5 0.067585986488543 0.932414013511457 1 0.025 1 0.333333333333333 0.00840375865961264 0.905700675949754 Inf 0.0408609105813669 Inf 0.385566831968631 664 4479 False False 0 0 0 0 0 0 0 1.59370326054442 0.115491055908661 21.9865025501046 7.47775368279368e-05 1.89320152683959e-06 0.000416562561410248 0.999906160559283 0.999661061221376 0.999988635406343 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-88A>G Rv0010c_c.-88A>G 2 upstream_gene_variant 13646 1 4 0 4 5 4 20841 27464 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.999854376001165 0.999627187086024 0.999960320981843 0.555555555555555 0.212008506778868 0.863004337734833 0 0 0.602364635616474 0 0 0.602364635616474 0 0 1.99652637191527 0.139142388186343 355 5574 False False 1.64723381795499 0.354499279020611 8.30243796120459 0 0 0.000176985413634466 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 5 3 13369 21310 0.000373859727830118 0.000121402023062639 0.000872246401868143 0.999859240838924 0.999588697652472 0.999970971136275 0.625 0.244863216366551 0.914766585862746 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85796099950175 0.289328306573868 409.5 4479 False False 0 0 0 0 0 0 0 2.65664347869449 0.516758123120163 17.1115025092299 0 0 0.000275889787465637 0.999859240838924 0.999588697652472 0.999970971136275 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-89C>A Rv0010c_c.-89C>A 2 upstream_gene_variant 13647 1 1 0 1 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 0 0 0.975 0 0 0.707598226178713 0 0 51.3471490467504 1 2027.5 5574 False False 0.439194051331254 0.00837049629364692 5.4704842261679 0 0 0.000176951454458875 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 3 13373 21310 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999859240838924 0.999588697652472 0.999970971136275 0.25 0.00630946320970987 0.805879550316756 0 0 0.975 0 0 0.707598226178713 0 0 62.0904541316821 1 1642.5 4479 False False 0 0 0 0 0 0 0 0.531169769934445 0.010122018243966 6.61631049307563 0 0 0.000275807277411719 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-89C>T Rv0010c_c.-89C>T 2 upstream_gene_variant 13647 1 0 0 0 8 1 20838 27467 0.000383766669864722 0.000165697303700768 0.000756032532322191 0.999963594000291 0.999797175631493 0.999999078280314 0.888888888888888 0.517503485082663 0.9971908632534 NA NA NA 0 0 0.975 NA NA NA NA 4465 5574 False False 10.5449659276322 1.4135292589455 466.907166500354 0 0 0.000177010891571197 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 7 1 13367 21312 0.000523403618962165 0.000210460468745924 0.00107811225334149 0.999953080279641 0.999738608085756 0.999998812096234 0.875 0.473490329124793 0.996840276468748 NA NA NA 0 0 0.975 NA NA NA NA 3590 4479 False False 0 0 0 0 0 0 0 11.1606194359242 1.43348631137374 501.805825213892 0 0 0.000275931061008045 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-8A>C Rv0010c_c.-8A>C 2 upstream_gene_variant 13566 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4431 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3556 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-8A>T Rv0010c_c.-8A>T 2 upstream_gene_variant 13566 1 0 0 0 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4411 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3538 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.90A>G Rv0010c_c.90A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 1 20843 27467 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999963594000291 0.999797175631493 0.999999078280314 0.75 0.194120449683243 0.99369053679029 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.95341361608213 0.31739219148065 207.323829234655 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.-90T>G Rv0010c_c.-90T>G 2 upstream_gene_variant 13648 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4466 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-91G>A Rv0010c_c.-91G>A 2 upstream_gene_variant 13649 1 11 0 11 5 14 20841 27454 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.999490316004077 0.999144984581285 0.999721323894632 0.263157894736842 0.0914657849076665 0.512029345345872 0 0 0.284914152918154 0 0 0.231635761650116 0 0 0.524937894647187 0.0034976562946787 104 5574 False False 0.470466868192505 0.132599379665363 1.38255220459935 0 0 0.000176985413634466 0.999490316004077 0.999144984581285 0.999721323894632 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 0 11 4 13 13370 21300 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 0.99939004363534 0.998957181904114 0.999675185224884 0.235294117647058 0.0681077404373566 0.49899327320458 0 0 0.284914152918154 0 0 0.24705263800047 0 0 0.634902073461687 0.0091307100528263 87 4479 False False 0 0 0 0 0 0 0 0.490190437834416 0.116409027471203 1.58722335447133 0 0 0.000275869155324334 0.99939004363534 0.998957181904114 0.999675185224884 4 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-91G>T Rv0010c_c.-91G>T 2 upstream_gene_variant 13649 1 0 0 0 2 3 20844 27465 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999890782000873 0.99968085216583 0.999977476056514 0.4 0.0527449505263169 0.853367200365326 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4481 5574 False False 0.878430243715217 0.0733354884838472 7.66963698207431 0 0 0.000176959943030976 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3602 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.93C>T Rv0010c_c.93C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.-93delT Rv0010c_c.-93delT 2 upstream_gene_variant 13650 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4539 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3658 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.96A>G Rv0010c_c.96A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv0010c c.-97C>A Rv0010c_c.-97C>A 2 upstream_gene_variant 13655 1 7 1 6 3 7 20843 27461 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999745158002038 0.999474999027776 0.999897534357495 0.3 0.0667395111777345 0.652452850059997 0.142857142857142 0.00361029686190058 0.578723197043195 0.125 0.0031597235312519 0.526509670875206 0.219586112044011 0.00477799328296539 1.81025578702097 0.251119620033225 421 5574 False False 0.564650002398887 0.0941990699429094 2.47377675968382 4.79754365764728e-05 1.21463215353938e-06 0.000267272712750976 0.999745158002038 0.999474999027776 0.999897534357495 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 1 4 3 5 13371 21308 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999765401398207 0.999452610763328 0.999923822225278 0.375 0.0852334141372535 0.755136783633448 0.2 0.00505076337946806 0.716417936118089 0.166666666666666 0.00421074451448947 0.641234578997674 0.39839952135218 0.00809359095010953 4.02663537137879 0.655133447710417 997 4479 False False 0 0 0 0 0 0 0 0.956158851245232 0.148446407940978 4.91535926753262 7.47831289261142e-05 1.89334310623943e-06 0.000416593707936992 0.999765401398207 0.999452610763328 0.999923822225278 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-97C>T Rv0010c_c.-97C>T 2 upstream_gene_variant 13655 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-98C>A Rv0010c_c.-98C>A 2 upstream_gene_variant 13656 NA 0 0 0 13 0 20833 27468 0.000623620838530173 0.000332092285535748 0.00106617452923529 1 0.999865711673152 1 1 0.752947361999529 1 NA NA NA NA NA NA NA NA NA NA 4484 5574 False False Inf 4.01743988819503 Inf 0 0 0.00017705337110378 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 10 0 13364 21313 0.000747719455660236 0.000358616922835118 0.00137465137870696 1 0.999826933785262 1 1 0.691502892181239 1 NA NA NA NA NA NA NA NA NA NA 3604 4479 False False 0 0 0 0 0 0 0 Inf 3.57391601991246 Inf 0 0 0.000275992994481552 1 0.999826933785262 1 2 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.-98C>T Rv0010c_c.-98C>T 2 upstream_gene_variant 13656 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4516 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3633 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c c.99T>C Rv0010c_c.99T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 918 3366 19928 24102 0.0440372253669768 0.0412917300998812 0.0469107657351747 0.87745740498034 0.873521384479478 0.881313389909842 0.214285714285714 0.202079852564034 0.226882348029718 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.329851100324805 0.30558757645738 0.355827413823095 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 664 2798 12710 18515 0.0496485718558396 0.0460281174341896 0.0534665409116015 0.86871862243701 0.864110999467782 0.873225422407741 0.191796649335644 0.178801809818591 0.205314086108038 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 0 0.345699327776556 0.316260540718253 0.377516274520393 NA NA NA NA NA NA 440 5) Not assoc w R Now listed Silent mutation no 0 +Isoniazid Rv0010c c.-9A>C Rv0010c_c.-9A>C 2 upstream_gene_variant 13567 NA 0 0 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 4527 5574 False False Inf 0.869878292971449 Inf 0 0 0.000176976922618654 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3646 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c LoF Rv0010c_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 131 4 127 83 258 20763 27210 0.00398157919984649 0.00317251590403286 0.00493341012577648 0.990607252075142 0.989394900322588 0.991714049347062 0.243401759530791 0.198790340912434 0.292532221528134 0.0305343511450381 0.008381012720474 0.0763343078286475 0.015267175572519 0.00417505130797305 0.0386265146453844 0.0412757247996796 0.0110704983867916 0.108304485854341 4.31935136070939e-26 5 5574 True False 0.421596332474247 0.324966702054485 0.542278633676485 0.000192613280685703 5.24830500383151e-05 0.000493092391398729 0.990607252075142 0.989394900322588 0.991714049347062 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 113 2 111 52 226 13322 21087 0.00388814116943322 0.00290517208380311 0.00509569182719799 0.989396143198986 0.987928736979922 0.990727658998409 0.18705035971223 0.14296778873298 0.237944502715636 0.0176991150442477 0.00215067831598572 0.062474152145144 0.0087719298245614 0.00106409240009665 0.0313262350682049 0.0285201881058359 0.0034121369800783 0.105502569277941 4.31480013677936e-21 5 4479 True False 0 0 0 0 0 0 0 0.364200278201072 0.263840802593228 0.494679661695581 0.000150105073551486 1.81789377541876e-05 0.000542124835809187 0.989396143198986 0.987928736979922 0.990727658998409 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ala129Pro Rv0010c_p.Ala129Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.43785249906968 0.0743380732312645 251 5574 False False 0 0 1.43785249906968 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 13374 21308 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.73894646374006 0.163960020972012 248.5 4479 False False 0 0 0 0 0 0 0 0 0 1.73894646374006 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ala129Thr Rv0010c_p.Ala129Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4494 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3614 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ala129Val Rv0010c_p.Ala129Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4461 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3586 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ala132Thr Rv0010c_p.Ala132Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 51.3533466119536 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3591 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ala132Val Rv0010c_p.Ala132Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4534 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3653 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ala133Gly Rv0010c_p.Ala133Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4552 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3669 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ala133Val Rv0010c_p.Ala133Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ala136Asp Rv0010c_p.Ala136Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ala136Ser Rv0010c_p.Ala136Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ala136Thr Rv0010c_p.Ala136Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ala136Val Rv0010c_p.Ala136Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 14 0 20832 27468 0.000671591672263264 0.000367212509754494 0.00112656023057506 1 0.999865711673152 1 1 0.768364238349883 1 NA NA NA NA NA NA NA NA NA NA 4471 5574 False False Inf 4.37287801662981 Inf 0 0 0.000177061869457058 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 13 0 13361 21313 0.000972035292358307 0.000517666151348512 0.00166163634851859 1 0.999826933785262 1 1 0.752947361999529 1 NA NA NA NA NA NA NA NA NA NA 3596 4479 False False 0 0 0 0 0 0 0 Inf 4.85999660216436 Inf 0 0 0.000276054955763573 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ala14Asp Rv0010c_p.Ala14Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4563 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3677 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ala14Ser Rv0010c_p.Ala14Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 2 3 20844 27465 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999890782000873 0.99968085216583 0.999977476056514 0.4 0.0527449505263169 0.853367200365326 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18895916093986 0.264083883232833 556.5 5574 False False 0.878430243715217 0.0733354884838472 7.66963698207431 0 0 0.000176959943030976 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ala18Ser Rv0010c_p.Ala18Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4509 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3626 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ala18Thr Rv0010c_p.Ala18Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 9 0 9 1 12 20845 27456 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999563128003495 0.99923699702714 0.999774242139628 0.0769230769230769 0.00194562849734675 0.360297435267877 0 0 0.336267116879942 0 0 0.264648469397051 0 0 0.667407828603266 0.012862467213806 143 5574 False False 0.10976253298153 0.00257183264698232 0.742010663012835 0 0 0.000176951454458875 0.999563128003495 0.99923699702714 0.999774242139628 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 1 11 13373 21302 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999483883076056 0.999076712346733 0.999742329032819 0.0833333333333333 0.00210759323186022 0.384796165150944 0 0 0.369416647552819 0 0 0.284914152918154 0 0 0.933378360656667 0.0270119170629039 115 4479 False False 0 0 0 0 0 0 0 0.144810099046246 0.00336819644582784 0.996572767671761 0 0 0.000275807277411719 0.999483883076056 0.999076712346733 0.999742329032819 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ala18Val Rv0010c_p.Ala18Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4568 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3682 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ala24Thr Rv0010c_p.Ala24Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ala24Val Rv0010c_p.Ala24Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ala26Gly Rv0010c_p.Ala26Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ala26Thr Rv0010c_p.Ala26Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 76 0 76 73 92 20773 27376 0.00350187086251559 0.00274588191763216 0.0044010917370229 0.996650648026794 0.995893875494286 0.997299121278756 0.442424242424242 0.365264823274524 0.521689445741141 0 0 0.0473787538669306 0 0 0.039303287739518 0 0 0.065555522752399 4.28255163463788e-19 7 5574 True False 1.04569685984524 0.757954210965826 1.43820713327208 0 0 0.00017756472040612 0.996650648026794 0.995893875494286 0.997299121278756 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 70 0 70 56 81 13318 21232 0.00418722895169732 0.00316449143546909 0.00543406401984753 0.996199502650964 0.995278510523041 0.996980745336428 0.408759124087591 0.325592219567081 0.495958574130964 0 0 0.0513337971510237 0 0 0.0445202624563217 0 0 0.0862887939292522 2.0612862079676e-15 7 4479 True False 0 0 0 0 0 0 0 1.10218603245584 0.769099778660004 1.56984209808269 0 0 0.000276946134560744 0.996199502650964 0.995278510523041 0.996980745336428 9 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ala26Val Rv0010c_p.Ala26Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 400 1123 20446 26345 0.0191883334932361 0.0173693389301239 0.0211430980442473 0.959116062327071 0.956707013304249 0.961427368412523 0.262639527248851 0.240684818620321 0.285513160349723 NA NA NA 0 0 0.00327945448481146 NA NA NA NA 4424 5574 False True 0.458954974591977 0.407827935049951 0.515684126868039 0 0 0.000180404318654798 0.959116062327071 0.956707013304249 0.961427368412523 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 272 844 13102 20469 0.0203379691939584 0.0180131297669807 0.0228746629322438 0.960399756017454 0.957694558412151 0.962978437986382 0.243727598566308 0.218793306441085 0.270020458032557 NA NA NA 0 0 0.00436117260012832 NA NA NA NA 3549 4479 False True 0 1 1 0 0 0 0 0.503483784900246 0.436774530013767 0.578945971541708 0 0 0.000281511234868246 0.960399756017454 0.957694558412151 0.962978437986382 181 5) Not assoc w R New NotAwR yes 5 +Isoniazid Rv0010c p.Ala44Glu Rv0010c_p.Ala44Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4412 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ala44Thr Rv0010c_p.Ala44Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 51.349017027227 1 2027.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ala44Val Rv0010c_p.Ala44Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ala51Gly Rv0010c_p.Ala51Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ala53Thr Rv0010c_p.Ala53Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ala57Thr Rv0010c_p.Ala57Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4425 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3550 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ala5Gly Rv0010c_p.Ala5Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ala5Pro Rv0010c_p.Ala5Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ala62Thr Rv0010c_p.Ala62Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 7.01573328293188 0.509380354735251 864 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ala62Val Rv0010c_p.Ala62Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 7.01606985634675 0.509383580255417 1109.5 5574 False False 0.439194051331254 0.00837049629364692 5.4704842261679 0 0 0.000176951454458875 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48598624162872 0.526186417038858 925 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ala69Val Rv0010c_p.Ala69Val 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4472 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ala7fs Rv0010c_p.Ala7fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 3 1 20843 27467 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999963594000291 0.999797175631493 0.999999078280314 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 4432 5574 False False 3.95341361608213 0.31739219148065 207.323829234655 0 0 0.00017696843241753 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 3 1 13371 21312 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999953080279641 0.999738608085756 0.999998812096234 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 3557 4479 False False 0 0 0 0 0 0 0 4.78169172088849 0.383875689805931 250.696170545132 0 0 0.000275848526268708 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ala7Glu Rv0010c_p.Ala7Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 11 1 20835 27467 0.000527679171063993 0.000263444034397523 0.000943967185544106 0.999963594000291 0.999797175631493 0.999999078280314 0.916666666666666 0.615203834849055 0.997892406768139 0 0 0.975 0 0 0.975 0 0 51.3755116759298 1 2027.5 5574 False False 14.501415886729 2.10741512283775 622.42135891494 0 0 0.000177036376844338 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 8 1 13366 21312 0.000598175564528189 0.000258283997825234 0.00117830226263269 0.999953080279641 0.999738608085756 0.999998812096234 0.888888888888888 0.517503485082663 0.9971908632534 0 0 0.975 0 0 0.975 0 0 62.1287648567502 1 1642.5 4479 False False 0 0 0 0 0 0 0 12.7559479275774 1.70975577844451 564.516212294525 0 0 0.000275951702410535 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ala7Pro Rv0010c_p.Ala7Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Arg100His Rv0010c_p.Arg100His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4426 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3551 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Arg116Gly Rv0010c_p.Arg116Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4510 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3627 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Arg116His Rv0010c_p.Arg116His 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 7.01573328293188 0.509380354735251 864 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.48495357236853 0.526173219289417 690 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Arg116Leu Rv0010c_p.Arg116Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4473 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3597 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Arg138Gly Rv0010c_p.Arg138Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Arg138His Rv0010c_p.Arg138His 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 7.01573328293188 0.509380354735251 864 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Arg37fs Rv0010c_p.Arg37fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4427 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3552 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Arg37Gln Rv0010c_p.Arg37Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4462 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Arg37Leu Rv0010c_p.Arg37Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 51.3428199661809 1 2027.5 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Arg37Trp Rv0010c_p.Arg37Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4500 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3619 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Arg56Cys Rv0010c_p.Arg56Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Arg58Cys Rv0010c_p.Arg58Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4569 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Arg58His Rv0010c_p.Arg58His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4474 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Arg58Pro Rv0010c_p.Arg58Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4558 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Arg58Ser Rv0010c_p.Arg58Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Arg60Ser Rv0010c_p.Arg60Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4540 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3659 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Arg71Pro Rv0010c_p.Arg71Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Arg75Gln Rv0010c_p.Arg75Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Arg75Trp Rv0010c_p.Arg75Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4566 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3680 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Arg80Gln Rv0010c_p.Arg80Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01632529799099 0.509386028876591 1135.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48598624162872 0.526186417038858 925 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Arg80Pro Rv0010c_p.Arg80Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Arg80* Rv0010c_p.Arg80* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Arg93Gly Rv0010c_p.Arg93Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Arg93His Rv0010c_p.Arg93His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4475 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3598 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Arg93Ser Rv0010c_p.Arg93Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Arg94His Rv0010c_p.Arg94His 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 2 2 20844 27466 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999927188000582 0.999737003036386 0.999991182007438 0.5 0.067585986488543 0.932414013511457 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01666191595533 0.509389255488555 1161.5 5574 False False 1.3176933410094 0.0955278435529395 18.1762534351792 0 0 0.000176959943030976 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Arg97His Rv0010c_p.Arg97His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Arg9His Rv0010c_p.Arg9His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4559 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3674 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Asn83Asp Rv0010c_p.Asn83Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4485 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3605 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Asn83Thr Rv0010c_p.Asn83Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Asp118Glu Rv0010c_p.Asp118Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 1.99597553667858 0.139114336996004 304.5 5574 False False 0 0 1.43785249906968 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 5 13374 21308 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 2.41409066157565 0.305475026346142 461 4479 False False 0 0 0 0 0 0 0 0 0 1.73894646374006 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Asp122Asn Rv0010c_p.Asp122Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Asp128Asn Rv0010c_p.Asp128Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4553 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3670 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Asp128Gly Rv0010c_p.Asp128Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4439 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3564 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Asp33Gly Rv0010c_p.Asp33Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Asp33His Rv0010c_p.Asp33His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4517 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Asp33Tyr Rv0010c_p.Asp33Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 3 3 20843 27465 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999890782000873 0.99968085216583 0.999977476056514 0.5 0.118117248757025 0.881882751242974 0 0 0.841886116991581 0 0 0.707598226178713 0 0 7.01674310006514 0.509390033358317 1167.5 5574 False False 1.31770858321738 0.176469385678871 9.83712695959095 0 0 0.00017696843241753 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 2 3 13372 21310 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999859240838924 0.999588697652472 0.999970971136275 0.4 0.0527449505263169 0.853367200365326 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.48622266823901 0.526189438000421 944 4479 False False 0 0 0 0 0 0 0 1.06241898494366 0.0886985485353837 9.27715037564111 0 0 0.000275827900298067 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Asp66Ala Rv0010c_p.Asp66Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4486 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3606 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Asp66Asn Rv0010c_p.Asp66Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4541 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3660 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Asp66fs Rv0010c_p.Asp66fs 2 frameshift (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 1.99597553667858 0.139114336996004 304.5 5574 False False 0 0 1.43785249906968 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.48495357236853 0.526173219289417 690 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Asp90Gly Rv0010c_p.Asp90Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4407 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3535 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Cys16Arg Rv0010c_p.Cys16Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4528 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3647 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Cys16Tyr Rv0010c_p.Cys16Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4570 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3683 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Gln140Arg Rv0010c_p.Gln140Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Gln140Glu Rv0010c_p.Gln140Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Gln2Arg Rv0010c_p.Gln2Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4535 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3654 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Gln2Lys Rv0010c_p.Gln2Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 5 2 20841 27466 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.999927188000582 0.999737003036386 0.999991182007438 0.714285714285714 0.290420863737342 0.963307433823914 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4542 5574 False False 3.29470754762247 0.539313466840718 34.60579842565 0 0 0.000176985413634466 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 5 2 13369 21311 0.000373859727830118 0.000121402023062639 0.000872246401868143 0.999906160559283 0.999661061221376 0.999988635406343 0.714285714285714 0.290420863737342 0.963307433823914 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3661 4479 False False 0 0 0 0 0 0 0 3.98515221781733 0.652287032938702 41.8973624237223 0 0 0.000275889787465637 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Gln2* Rv0010c_p.Gln2* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Gln77Pro Rv0010c_p.Gln77Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Gln77* Rv0010c_p.Gln77* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4487 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Glu105Ala Rv0010c_p.Glu105Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4556 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3673 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Glu105Lys Rv0010c_p.Glu105Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4506 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3623 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Glu125Asp Rv0010c_p.Glu125Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 51.3533466119536 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Glu125Gly Rv0010c_p.Glu125Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 51.3533466119536 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Glu125Lys Rv0010c_p.Glu125Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Glu91Asp Rv0010c_p.Glu91Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 1 7 20845 27461 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999745158002038 0.999474999027776 0.999897534357495 0.125 0.0031597235312519 0.526509670875206 0 0 0.4592581264399 0 0 0.409616397225003 0 0 1.11902215604345 0.040211691945573 201 5574 False False 0.188198608779083 0.00417990056987037 1.46513319151887 0 0 0.000176951454458875 0.999745158002038 0.999474999027776 0.999897534357495 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 1 6 13373 21307 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999718481677849 0.999387354605726 0.999896680954833 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.521823750104981 0 0 0.4592581264399 0 0 1.73899488328392 0.163960074115365 257 4479 False False 0 0 0 0 0 0 0 0.265547496198808 0.00577686092206708 2.18912593855065 0 0 0.000275807277411719 0.999718481677849 0.999387354605726 0.999896680954833 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Gly109fs Rv0010c_p.Gly109fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4408 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3536 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Gly109Glu Rv0010c_p.Gly109Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4457 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3581 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Gly110fs Rv0010c_p.Gly110fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4543 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Gly110Glu Rv0010c_p.Gly110Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 9 3 20837 27465 0.000431737503597812 0.000197436276106449 0.000819413341228355 0.999890782000873 0.99968085216583 0.999977476056514 0.75 0.42814153812181 0.945139355472007 0 0 0.975 0 0 0.707598226178713 0 0 51.3668470598871 1 2027.5 5574 False False 3.95426404952728 0.986636627683945 22.7091373085176 0 0 0.000177019385846931 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 9 3 13365 21310 0.000672947510094212 0.000307759154923187 0.00127707788784856 0.999859240838924 0.999588697652472 0.999970971136275 0.75 0.42814153812181 0.945139355472007 0 0 0.975 0 0 0.707598226178713 0 0 62.1275840562474 1 1642.5 4479 False False 0 0 0 0 0 0 0 4.78338945005611 1.19341740935517 27.4726907243458 0 0 0.000275972346901473 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Gly120Arg Rv0010c_p.Gly120Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Gly120Ser Rv0010c_p.Gly120Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4511 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3628 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Gly12Arg Rv0010c_p.Gly12Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4501 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3620 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Gly12* Rv0010c_p.Gly12* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Gly134Asp Rv0010c_p.Gly134Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 12 0 12 4 36 20842 27432 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.998689384010484 0.998186012178885 0.999081897081075 0.1 0.0279254152942193 0.236637399876099 0 0 0.264648469397051 0 0 0.0973937559144919 0 0 0.47374800584407 0.00183694040532901 81 5574 False False 0.146243162844256 0.0378063258439215 0.408114201121444 0 0 0.000176976922618654 0.998689384010484 0.998186012178885 0.999081897081075 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 0 11 4 25 13370 21288 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 0.998827006991038 0.998268914575298 0.99924076142744 0.137931034482758 0.0388948312954388 0.316640609439137 0 0 0.284914152918154 0 0 0.137185171530712 0 0 0.634543442521641 0.00913163216038525 95 4479 False False 0 0 0 0 0 0 0 0.254755422587883 0.0644534063061161 0.738024189617734 0 0 0.000275869155324334 0.998827006991038 0.998268914575298 0.99924076142744 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Gly134Cys Rv0010c_p.Gly134Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Gly134Ser Rv0010c_p.Gly134Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Gly137Asp Rv0010c_p.Gly137Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Gly137fs Rv0010c_p.Gly137fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Gly15Asp Rv0010c_p.Gly15Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4507 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3624 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Gly15Ser Rv0010c_p.Gly15Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 2 4 20844 27464 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999854376001165 0.999627187086024 0.999960320981843 0.333333333333333 0.0432718682927417 0.777221904496487 0.333333333333333 0.00840375865961264 0.905700675949754 0.2 0.00505076337946806 0.716417936118089 0.658798695068125 0.011171578266319 12.6564257726381 1 1253.5 5574 False False 0.658798695068125 0.0595601499680727 4.59736120623929 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 62.0858160113928 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Gly15Val Rv0010c_p.Gly15Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4446 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3570 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Gly19Ala Rv0010c_p.Gly19Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 10 0 20836 27468 0.000479708337330902 0.000230061997553563 0.000882023176671562 1 0.999865711673152 1 1 0.691502892181239 1 NA NA NA NA NA NA NA NA NA NA 4512 5574 False False Inf 2.95450432812812 Inf 0 0 0.000177027880937939 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 7 0 13367 21313 0.000523403618962165 0.000210460468745924 0.00107811225334149 1 0.999826933785262 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 3629 4479 False False 0 0 0 0 0 0 0 Inf 2.29755378883993 Inf 0 0 0.000275931061008045 1 0.999826933785262 1 4 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Gly19Arg Rv0010c_p.Gly19Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 5 4 20841 27464 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.999854376001165 0.999627187086024 0.999960320981843 0.555555555555555 0.212008506778868 0.863004337734833 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.18930211236502 0.264094733817729 565.5 5574 False False 1.64723381795499 0.354499279020611 8.30243796120459 0 0 0.000176985413634466 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 2 3 13372 21310 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999859240838924 0.999588697652472 0.999970971136275 0.4 0.0527449505263169 0.853367200365326 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.48622266823901 0.526189438000421 944 4479 False False 0 0 0 0 0 0 0 1.06241898494366 0.0886985485353837 9.27715037564111 0 0 0.000275827900298067 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Gly19Glu Rv0010c_p.Gly19Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Gly19Val Rv0010c_p.Gly19Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4488 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Gly20fs Rv0010c_p.Gly20fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4529 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3648 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Gly20Glu Rv0010c_p.Gly20Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Gly36Ala Rv0010c_p.Gly36Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 2 4 20844 27464 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999854376001165 0.999627187086024 0.999960320981843 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.841886116991581 0 0 0.602364635616474 0 0 7.01615100815696 0.509384357655263 1115 5574 False False 0.658798695068125 0.0595601499680727 4.59736120623929 0 0 0.000176959943030976 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 2 4 13372 21309 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999812321118566 0.999519537882235 0.999948861529775 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.841886116991581 0 0 0.602364635616474 0 0 8.48582446968625 0.526184348245175 907.5 4479 False False 0 0 0 0 0 0 0 0.796776847143284 0.0720475461928349 5.56077695166295 0 0 0.000275827900298067 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Gly36Arg Rv0010c_p.Gly36Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 7.01606985634675 0.509383580255417 1109.5 5574 False False 0.439194051331254 0.00837049629364692 5.4704842261679 0 0 0.000176951454458875 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3607 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 2 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Gly36Glu Rv0010c_p.Gly36Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 51.349017027227 1 2027.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Gly36Trp Rv0010c_p.Gly36Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Gly36Val Rv0010c_p.Gly36Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 62 2 20784 27466 0.00297419169145159 0.00228103289080476 0.00381118014718562 0.999927188000582 0.999737003036386 0.999991182007438 0.96875 0.891629477775482 0.996192818618127 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.03691827151118 0.509584113261751 1216 5574 False False 40.9664164742109 10.8710199753665 345.6234100293 0 0 0.00017747075203645 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 17 2 13357 21311 0.0012711230746224 0.000740644897312986 0.00203441363276193 0.999906160559283 0.999661061221376 0.999988635406343 0.894736842105263 0.668623335543234 0.986987835628222 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.49615164746089 0.526316398646916 984 4479 False False 0 0 0 0 0 0 0 13.5616904993636 3.21803032516403 121.17061206255 0 0 0.000276137614096336 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Gly41Arg Rv0010c_p.Gly41Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 4 20845 27464 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999854376001165 0.999627187086024 0.999960320981843 0.2 0.00505076337946806 0.716417936118089 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4433 5574 False False 0.329383545214679 0.00669260119676484 3.32889360843958 0 0 0.000176951454458875 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 3 13373 21310 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999859240838924 0.999588697652472 0.999970971136275 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3558 4479 False False 0 0 0 0 0 0 0 0.531169769934445 0.010122018243966 6.61631049307563 0 0 0.000275807277411719 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Gly41Glu Rv0010c_p.Gly41Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Gly41* Rv0010c_p.Gly41* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Gly46Arg Rv0010c_p.Gly46Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 25 0 25 13 27 20833 27441 0.000623620838530173 0.000332092285535748 0.00106617452923529 0.999017038007863 0.998570161716172 0.99935212504807 0.325 0.185728966763349 0.491294875478448 0 0 0.137185171530712 0 0 0.127702867615432 0 0 0.209483119732721 1.14983113445857e-06 35 5574 True False 0.634202147234355 0.300363253587957 1.27247794544048 0 0 0.00017705337110378 0.999017038007863 0.998570161716172 0.99935212504807 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 25 0 25 11 27 13363 21286 0.000822491401226259 0.000410653977896139 0.00147118664271154 0.998733167550321 0.998157356503829 0.999164988624762 0.289473684210526 0.154246286787909 0.459032066924292 0 0 0.137185171530712 0 0 0.127702867615432 0 0 0.253330214668174 9.2133322229074e-06 27 4479 True False 0 0 0 0 0 0 0 0.648961615960044 0.290406652885067 1.35220373989884 0 0 0.000276013645151466 0.998733167550321 0.998157356503829 0.999164988624762 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Gly46fs Rv0010c_p.Gly46fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 10 0 20836 27468 0.000479708337330902 0.000230061997553563 0.000882023176671562 1 0.999865711673152 1 1 0.691502892181239 1 1 0.025 1 1 0.025 1 Inf 0.0338005505707578 Inf 0.431363212917917 599 5574 False False Inf 2.95450432812812 Inf 4.79915534865863e-05 1.21504019787923e-06 0.000267362490730224 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 4 0 13370 21313 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 1 0.999826933785262 1 1 0.397635364383525 1 1 0.025 1 1 0.025 1 Inf 0.0408708578619459 Inf 0.385509168492676 483 4479 False False 0 0 0 0 0 0 0 Inf 1.05210128917758 Inf 7.47887218607434e-05 1.89348470681633e-06 0.000416624859121756 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Gly46Ser Rv0010c_p.Gly46Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Gly67Ala Rv0010c_p.Gly67Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.His81Asp Rv0010c_p.His81Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.His81fs Rv0010c_p.His81fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.His81Tyr Rv0010c_p.His81Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ile104Thr Rv0010c_p.Ile104Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ile113Leu Rv0010c_p.Ile113Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ile13Thr Rv0010c_p.Ile13Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4447 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3571 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ile13Val Rv0010c_p.Ile13Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4571 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3684 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ile48fs Rv0010c_p.Ile48fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4489 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3608 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ile48Met Rv0010c_p.Ile48Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ile70Thr Rv0010c_p.Ile70Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 51.3533466119536 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3577 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ile86Val Rv0010c_p.Ile86Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4413 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3539 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ile87Met Rv0010c_p.Ile87Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 975 3152 19871 24316 0.046771562889763 0.043944624803989 0.0497257379316302 0.885248288918013 0.881420094292473 0.888994781498923 0.236249091349648 0.22335862066347 0.249513940052537 NA NA NA 0 0 0.00116964520724214 NA NA NA NA 4547 5574 False True 0.378521731666712 0.351083966178579 0.407826112022925 0 0 0.000185624129183366 0.885248288918013 0.881420094292473 0.888994781498923 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 703 2537 12671 18776 0.0525646777329146 0.0488428338990806 0.0564826885418487 0.88096466945057 0.876541641548161 0.885283495507786 0.216975308641975 0.202888613760381 0.231574682846661 NA NA NA 0 0 0.00145297551395502 NA NA NA NA 3665 4479 False True 0 1 1 0 0 0 0 0.410607656669454 0.376035439304047 0.447954812461608 0 0 0.000291085355431287 0.88096466945057 0.876541641548161 0.885283495507786 400 5) Not assoc w R New NotAwR yes 5 +Isoniazid Rv0010c p.Ile87Thr Rv0010c_p.Ile87Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4518 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3634 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ile87Val Rv0010c_p.Ile87Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.658815063564403 0.011171855707321 12.6567401482543 1 2027.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.59365886487699 0.0203005577541163 124.983813232444 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Leu111fs Rv0010c_p.Leu111fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 49 204 20797 27264 0.00235057085292142 0.00173945571836352 0.00310640272658815 0.992573176059414 0.991485755159587 0.993554353648024 0.193675889328063 0.146852583978524 0.247833387821044 NA NA NA 0 0 0.0179202306624395 NA NA NA NA 4453 5574 False True 0.314887045360049 0.225551072307281 0.432219642521095 0 0 0.000177359826654463 0.992573176059414 0.991485755159587 0.993554353648024 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 32 188 13342 21125 0.00239270225811275 0.00163716457667549 0.00337611758106976 0.991179092572608 0.989830987728746 0.992390529985622 0.145454545454545 0.101666319903495 0.199090707176246 NA NA NA 0 0 0.0194304466268233 NA NA NA NA 3578 4479 False True 0 1 1 0 0 0 0 0.269505672376784 0.179088054921675 0.393901472927977 0 0 0.000276448024201715 0.991179092572608 0.989830987728746 0.992390529985622 44 5) Not assoc w R New NotAwR yes 5 +Isoniazid Rv0010c p.Leu111Met Rv0010c_p.Leu111Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Leu111Ser Rv0010c_p.Leu111Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Leu112Arg Rv0010c_p.Leu112Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Leu112Pro Rv0010c_p.Leu112Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 51.3533466119536 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Leu114Ser Rv0010c_p.Leu114Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4495 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3615 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Leu119Arg Rv0010c_p.Leu119Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Leu119Pro Rv0010c_p.Leu119Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Leu119Val Rv0010c_p.Leu119Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4476 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Leu127Arg Rv0010c_p.Leu127Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Leu127Val Rv0010c_p.Leu127Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4434 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3559 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Leu30Ile Rv0010c_p.Leu30Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 1.99604811372315 0.139118032244638 322.5 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.41420404242617 0.305473156458586 444 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Leu30Lys Rv0010c_p.Leu30Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4467 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3592 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Leu30Val Rv0010c_p.Leu30Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 36 2 34 11 59 20835 27409 0.000527679171063993 0.000263444034397523 0.000943967185544106 0.997852046017183 0.997230158853038 0.998364488122291 0.157142857142857 0.0811437635504477 0.263799765216311 0.0555555555555555 0.00680030065402281 0.186636706457554 0.0327868852459016 0.00399560316731648 0.113472167188181 0.0773839269329041 0.00899987420617254 0.301933255129283 6.93839060666267e-07 32 5574 True False 0.245267700617848 0.116146889287907 0.471535642192025 9.59831069731727e-05 1.1624210921735e-05 0.00034668051841439 0.997852046017183 0.997230158853038 0.998364488122291 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 30 2 28 11 45 13363 21268 0.000822491401226259 0.000410653977896139 0.00147118664271154 0.997888612583869 0.997175806123482 0.998459535429248 0.196428571428571 0.102348302601079 0.324332985924114 0.0666666666666666 0.00817813446065631 0.220735401522961 0.0425531914893617 0.00519558317674383 0.145405245488214 0.113682770122192 0.0131367588414667 0.450942423915165 0.000110192862694325 37 4479 True False 0 0 0 0 0 0 0 0.389047702195947 0.181402502807239 0.764327395496159 0.000149644594089038 1.81231683879501e-05 0.000540462076832832 0.997888612583869 0.997175806123482 0.998459535429248 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Leu39Phe Rv0010c_p.Leu39Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 9 1 8 2 23 20844 27445 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999162662006698 0.998743845166008 0.999469127824854 0.08 0.00983959001879751 0.260305842105214 0.111111111111111 0.00280913674659921 0.482496514917337 0.0416666666666666 0.00105435244546974 0.211201683456973 0.164585732105162 0.00371328636196584 1.22784750905053 0.0876121194510428 290 5574 False False 0.114494422334025 0.0130979407951893 0.463468020774903 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 0.999162662006698 0.998743845166008 0.999469127824854 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 1 7 1 22 13373 21291 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.998967766152113 0.998437600176231 0.999352995040555 0.0434782608695652 0.0011001686304415 0.21948660745348 0.125 0.0031597235312519 0.526509670875206 0.0434782608695652 0.0011001686304415 0.21948660745348 0.2274412195148 0.00505030491526771 1.77068250745276 0.163591592073891 229 4479 False False 0 0 0 0 0 0 0 0.0723676607547092 0.00175760069415692 0.447823447134869 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.998967766152113 0.998437600176231 0.999352995040555 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Leu39Ser Rv0010c_p.Leu39Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 51.3446878573018 1 2027.5 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3641 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Leu49Val Rv0010c_p.Leu49Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4502 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3621 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Leu61_Ala62insArgAlaArgProArgLeu Rv0010c_p.Leu61_Ala62insArgAlaArgProArgLeu 2 inframe_insertion (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4557 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Leu61Arg Rv0010c_p.Leu61Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4496 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3616 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Leu68fs Rv0010c_p.Leu68fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4497 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Leu79Phe Rv0010c_p.Leu79Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4448 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3572 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Leu98Val Rv0010c_p.Leu98Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 6 20846 27462 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 0 0 0.4592581264399 0 0 0.975 0 0 0.4592581264399 0 0 51.3390841836116 1 2027.5 5574 False False 0 0 1.11900921779861 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 62.0829055149378 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Met1? Rv0010c_p.Met1? 2 start_lost (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4548 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3666 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Met23Ile Rv0010c_p.Met23Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 19 1 18 7 46 20839 27422 0.000335795836131632 0.000135017659185429 0.000691744589626827 0.998325324013397 0.997766841513316 0.998773673863725 0.132075471698113 0.0547901018531811 0.253368232863736 0.0526315789473684 0.00133162880417942 0.260280654195214 0.0212765957446808 0.000538531705342315 0.1129377171464 0.0731054486513001 0.00175884699358495 0.463090506103041 0.000630441604620981 71 5574 True False 0.200245359349213 0.0762557610508389 0.446685838139333 4.79846449136276e-05 1.21486528816812e-06 0.000267324007069132 0.998325324013397 0.997766841513316 0.998773673863725 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 17 1 16 6 34 13368 21279 0.000448631673396141 0.000164657143425453 0.000976224581517196 0.998404729507812 0.997771476125476 0.998894983644582 0.15 0.0571022581545258 0.298352666839576 0.0588235294117647 0.00148817439126663 0.28688939666722 0.0285714285714285 0.000723104376338095 0.149172079656431 0.0994866472172352 0.00237639326297058 0.640557499090586 0.00464598997668233 66 4479 False False 0 0 0 0 0 0 0 0.280903474495722 0.0963685390980562 0.677114960871488 7.47999102401077e-05 1.89376797152033e-06 0.000416687175469531 0.998404729507812 0.997771476125476 0.998894983644582 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Phe50Tyr Rv0010c_p.Phe50Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Phe74Leu Rv0010c_p.Phe74Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Pro123Leu Rv0010c_p.Pro123Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Pro123Ser Rv0010c_p.Pro123Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4560 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Pro35Leu Rv0010c_p.Pro35Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 11 1 10 1 11 20845 27457 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999599534003203 0.9992835689522 0.999800072407065 0.0833333333333333 0.00210759323186022 0.384796165150944 0.0909090909090909 0.00229897221381426 0.412779916988382 0.0833333333333333 0.00210759323186022 0.384796165150944 0.13171983689134 0.00303931004401975 0.92604176804568 0.0294406890252179 174 5574 False False 0.119745306264855 0.00278612189885952 0.824021419435307 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999599534003203 0.9992835689522 0.999800072407065 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 7 13374 21306 0 0 0.000275786657608973 0.99967156195749 0.999323409938814 0.999867941002665 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 1.10552510564584 0.0484388314759391 130.5 4479 False False 0 0 0 0 0 0 0 0 0 1.10552510564584 0 0 0.000275786657608973 0.99967156195749 0.999323409938814 0.999867941002665 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Pro35Ser Rv0010c_p.Pro35Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 51.3428199661809 1 2027.5 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 62.0858160113928 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Pro59Glu Rv0010c_p.Pro59Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4513 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3630 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Pro59Leu Rv0010c_p.Pro59Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4409 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3537 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Pro59Ser Rv0010c_p.Pro59Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4414 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3540 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Pro65Ala Rv0010c_p.Pro65Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 1 7 3 10 20843 27458 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999635940002912 0.999330582956894 0.999825405716755 0.23076923076923 0.0503810734911515 0.53813153923404 0.125 0.0031597235312519 0.526509670875206 0.0909090909090909 0.00229897221381426 0.412779916988382 0.18819610557844 0.00417984502220455 1.46511372978792 0.149408027438265 366 5574 False False 0.395211821714724 0.0698820144739222 1.53517921560294 4.79754365764728e-05 1.21463215353938e-06 0.000267272712750976 0.999635940002912 0.999330582956894 0.999825405716755 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 1 6 3 7 13371 21306 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.99967156195749 0.999323409938814 0.999867941002665 0.3 0.0667395111777345 0.652452850059997 0.142857142857142 0.00361029686190058 0.578723197043195 0.125 0.0031597235312519 0.526509670875206 0.265574751327499 0.00577745326964772 2.18935114256574 0.261209562342104 276 4479 False False 0 0 0 0 0 0 0 0.682906503413571 0.113956481543253 2.99204017959139 7.47831289261142e-05 1.89334310623943e-06 0.000416593707936992 0.99967156195749 0.999323409938814 0.999867941002665 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Pro65Arg Rv0010c_p.Pro65Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Pro65Leu Rv0010c_p.Pro65Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4498 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3617 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Pro8His Rv0010c_p.Pro8His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Pro8Ser Rv0010c_p.Pro8Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 8 20846 27460 0 0 0.00017694296670111 0.99970875200233 0.999426206431739 0.999874251669172 0 0 0.369416647552819 0 0 0.4592581264399 0 0 0.369416647552819 0 0 1.11892773394207 0.0402061734919759 183 5574 False False 0 0 0.771808536885009 0 0 0.00017694296670111 0.99970875200233 0.999426206431739 0.999874251669172 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 8 13374 21305 0 0 0.000275786657608973 0.999624642237132 0.999260530264256 0.999837933676441 0 0 0.369416647552819 0 0 0.4592581264399 0 0 0.369416647552819 0 0 1.35322863698641 0.0884788157694752 154 4479 False False 0 0 0 0 0 0 0 0 0 0.93343997011793 0 0 0.000275786657608973 0.999624642237132 0.999260530264256 0.999837933676441 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ser108Asn Rv0010c_p.Ser108Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 2 11 20844 27457 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999599534003203 0.9992835689522 0.999800072407065 0.153846153846153 0.0192066719825284 0.454471055676557 0 0 0.369416647552819 0 0 0.284914152918154 0 0 0.771798272639714 0.0121102225573466 120 5574 False False 0.239502102196402 0.02578903914769 1.09755702800922 0 0 0.000176959943030976 0.999599534003203 0.9992835689522 0.999800072407065 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 1 9 13373 21304 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999577722516773 0.999198537836033 0.999806890245066 0.1 0.00252857854446178 0.445016117028195 0 0 0.4592581264399 0 0 0.336267116879942 0 0 1.35326630722375 0.088479592431554 155.5 4479 False False 0 0 0 0 0 0 0 0.177006738286929 0.00404223590282617 1.27765801502961 0 0 0.000275807277411719 0.999577722516773 0.999198537836033 0.999806890245066 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ser108Thr Rv0010c_p.Ser108Thr 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4536 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3655 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ser11Leu Rv0010c_p.Ser11Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 4519 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 3635 4479 False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 0 0 0.000275827900298067 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ser27Pro Rv0010c_p.Ser27Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4418 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3544 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ser27Tyr Rv0010c_p.Ser27Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 17 2 20829 27466 0.000815504173462534 0.000475130725961031 0.00130538114673077 0.999927188000582 0.999737003036386 0.999991182007438 0.894736842105263 0.668623335543234 0.986987835628222 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.02171506408448 0.509437737221087 1213 5574 False False 11.2084593595467 2.65997882249922 100.060556571033 0 0 0.000177087369412526 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 9 0 13365 21313 0.000672947510094212 0.000307759154923187 0.00127707788784856 1 0.999826933785262 1 1 0.663732883120057 1 NA NA NA NA NA NA NA NA NA NA 3639 4479 False False 0 0 0 0 0 0 0 Inf 3.14671336895126 Inf 0 0 0.000275972346901473 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ser52Asn Rv0010c_p.Ser52Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 3 3 20843 27465 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999890782000873 0.99968085216583 0.999977476056514 0.5 0.118117248757025 0.881882751242974 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4440 5574 False False 1.31770858321738 0.176469385678871 9.83712695959095 0 0 0.00017696843241753 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 3 2 13371 21311 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999906160559283 0.999661061221376 0.999988635406343 0.6 0.146632799634673 0.947255049473683 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3565 4479 False False 0 0 0 0 0 0 0 2.39073367736145 0.273835790357664 28.6284716983702 0 0 0.000275848526268708 0.999906160559283 0.999661061221376 0.999988635406343 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ser52Cys Rv0010c_p.Ser52Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4523 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3642 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ser52Thr Rv0010c_p.Ser52Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 1 7 20845 27461 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999745158002038 0.999474999027776 0.999897534357495 0.125 0.0031597235312519 0.526509670875206 0 0 0.521823750104981 0 0 0.409616397225003 0 0 1.43781666391196 0.0743359452141025 238.5 5574 False False 0.188198608779083 0.00417990056987037 1.46513319151887 0 0 0.000176951454458875 0.999745158002038 0.999474999027776 0.999897534357495 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.85633740727807 0.289259828934126 294 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ser82Cys Rv0010c_p.Ser82Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Ser82Pro Rv0010c_p.Ser82Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 57 20846 27411 0 0 0.00017694296670111 0.997924858016601 0.997312237758694 0.99842794044801 0 0 0.0626674809144849 NA NA NA 0 0 0.0626674809144849 NA NA NA NA 4468 5574 False True 0 0 0.0879279210178543 0 0 0.00017694296670111 0.997924858016601 0.997312237758694 0.99842794044801 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 47 13374 21266 0 0 0.000275786657608973 0.997794773143152 0.997068582412381 0.998379246067552 0 0 0.0754857336910586 NA NA NA 0 0 0.0754857336910586 NA NA NA NA 3593 4479 False True 1 1 1 0 0 0 0 0 0 0.129862959833188 0 0 0.000275786657608973 0.997794773143152 0.997068582412381 0.998379246067552 7 5) Not assoc w R New NotAwR yes 5 +Isoniazid Rv0010c p.Ter142Cysext*? Rv0010c_p.Ter142Cysext*? 2 stop_lost (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Thr106Ala Rv0010c_p.Thr106Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Thr106Lys Rv0010c_p.Thr106Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4415 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3541 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Thr10Ile Rv0010c_p.Thr10Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Thr10Ser Rv0010c_p.Thr10Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4477 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Thr121Ala Rv0010c_p.Thr121Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4454 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Thr121Ser Rv0010c_p.Thr121Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 13 193 20833 27275 0.000623620838530173 0.000332092285535748 0.00106617452923529 0.99297364205621 0.991913674588316 0.993927212418165 0.0631067961165048 0.0340264424870026 0.105497037811644 NA NA NA 0 0 0.0189318628972876 NA NA NA NA 4572 5574 False True 0.0881858669324201 0.0461074993872253 0.154445881041166 0 0 0.00017705337110378 0.99297364205621 0.991913674588316 0.993927212418165 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 10 182 13364 21131 0.000747719455660236 0.000358616922835118 0.00137465137870696 0.991460610894759 0.990132440188631 0.992651983432231 0.0520833333333333 0.0252553276984428 0.0936953602695077 NA NA NA 0 0 0.0200645417640249 NA NA NA NA 3685 4479 False True 1 1 1 0 0 0 0 0.0868784762080182 0.04097072358677 0.163542668867481 0 0 0.000275992994481552 0.991460610894759 0.990132440188631 0.992651983432231 31 5) Not assoc w R New NotAwR yes 5 +Isoniazid Rv0010c p.Thr131Ala Rv0010c_p.Thr131Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Thr131Ser Rv0010c_p.Thr131Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4520 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3636 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Thr29Ala Rv0010c_p.Thr29Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Thr29Ile Rv0010c_p.Thr29Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 5 3 20841 27465 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.999890782000873 0.99968085216583 0.999977476056514 0.625 0.244863216366551 0.914766585862746 0 0 0.975 0 0 0.707598226178713 0 0 51.356996164522 1 2027.5 5574 False False 2.19639172784415 0.427240710906458 14.1452254524229 0 0 0.000176985413634466 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 3 13371 21310 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999859240838924 0.999588697652472 0.999970971136275 0.5 0.118117248757025 0.881882751242974 0 0 0.975 0 0 0.707598226178713 0 0 62.0997324515157 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59374766285244 0.213424225946693 11.9045637110481 0 0 0.000275848526268708 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Thr29Ser Rv0010c_p.Thr29Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4544 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3662 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Thr32Ile Rv0010c_p.Thr32Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 4 6 20842 27462 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999781564001747 0.999524617886493 0.999919833755107 0.4 0.121552258119827 0.737621923393055 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.119223977151 0.0402234912969853 213.5 5574 False False 0.878418577871605 0.182308638457443 3.70497296035774 0 0 0.000176976922618654 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 2 5 13372 21308 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999765401398207 0.999452610763328 0.999923822225278 0.285714285714285 0.0366925661760855 0.709579136262657 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.73920648339371 0.16396031861284 265 4479 False False 0 0 0 0 0 0 0 0.637391564463057 0.0606680462541562 3.89402937569226 0 0 0.000275827900298067 0.999765401398207 0.999452610763328 0.999923822225278 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Thr34Ala Rv0010c_p.Thr34Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4503 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Thr34Lys Rv0010c_p.Thr34Lys 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 6 8 20840 27460 0.000287825002398541 0.000105633792978048 0.000626367784710498 0.99970875200233 0.999426206431739 0.999874251669172 0.428571428571428 0.176611089982117 0.711390599961692 NA NA NA 0 0 0.369416647552819 NA NA NA NA 4504 5574 False False 0.988243761996161 0.282578761969438 3.24875521384802 0 0 0.000176993905465082 0.99970875200233 0.999426206431739 0.999874251669172 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 5 5 13369 21308 0.000373859727830118 0.000121402023062639 0.000872246401868143 0.999765401398207 0.999452610763328 0.999923822225278 0.5 0.187086028447398 0.812913971552601 NA NA NA 0 0 0.521823750104981 NA NA NA NA 3622 4479 False False 0 0 0 0 0 0 0 1.59383648739621 0.366730515035009 6.92672846175378 0 0 0.000275889787465637 0.999765401398207 0.999452610763328 0.999923822225278 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Thr34Met Rv0010c_p.Thr34Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 9 1 8 7 11 20839 27457 0.000335795836131632 0.000135017659185429 0.000691744589626827 0.999599534003203 0.9992835689522 0.999800072407065 0.388888888888888 0.172985854789751 0.642548794106937 0.111111111111111 0.00280913674659921 0.482496514917337 0.0833333333333333 0.00210759323186022 0.384796165150944 0.164697202360957 0.0037157978497026 1.22868028401863 0.0876238204816187 293 5574 False False 0.838458484746694 0.275552585752154 2.36892341668732 4.79846449136276e-05 1.21486528816812e-06 0.000267324007069132 0.999599534003203 0.9992835689522 0.999800072407065 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 2 9 13372 21304 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999577722516773 0.999198537836033 0.999806890245066 0.181818181818181 0.0228311982999596 0.517755852360172 0 0 0.4592581264399 0 0 0.336267116879942 0 0 1.35336747914124 0.0884816829284013 171 4479 False False 0 0 0 0 0 0 0 0.354039950809319 0.0372201067241714 1.71091270173505 0 0 0.000275827900298067 0.999577722516773 0.999198537836033 0.999806890245066 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Thr34Ser Rv0010c_p.Thr34Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 1.99604811372315 0.139118032244638 322.5 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.41420404242617 0.305473156458586 444 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Thr40Ala Rv0010c_p.Thr40Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 58 20846 27410 0 0 0.00017694296670111 0.997888452016892 0.997271178461667 0.99839623461966 0 0 0.0616210089039198 NA NA NA 0 0 0.0616210089039198 NA NA NA NA 4478 5574 False True 0 0 0.0863604964756482 0 0 0.00017694296670111 0.997888452016892 0.997271178461667 0.99839623461966 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 48 13374 21265 0 0 0.000275786657608973 0.997747853422793 0.997015076381681 0.998338992326197 0 0 0.0739727853472802 NA NA NA 0 0 0.0739727853472802 NA NA NA NA 3599 4479 False True 1 1 1 0 0 0 0 0 0 0.127046990998762 0 0 0.000275786657608973 0.997747853422793 0.997015076381681 0.998338992326197 7 5) Not assoc w R New NotAwR yes 5 +Isoniazid Rv0010c p.Thr40Pro Rv0010c_p.Thr40Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 1 8 20845 27460 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.99970875200233 0.999426206431739 0.999874251669172 0.111111111111111 0.00280913674659921 0.482496514917337 0 0 0.4592581264399 0 0 0.369416647552819 0 0 1.11898141216371 0.0402093104308738 185 5574 False False 0.164667786039817 0.00371513512243138 1.22846047298172 0 0 0.000176951454458875 0.99970875200233 0.999426206431739 0.999874251669172 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 4 13373 21309 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999812321118566 0.999519537882235 0.999948861529775 0.2 0.00505076337946806 0.716417936118089 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.85662582934577 0.289271991675179 380.5 4479 False False 0 0 0 0 0 0 0 0.398358633066626 0.00809276091420046 4.02622197901862 0 0 0.000275807277411719 0.999812321118566 0.999519537882235 0.999948861529775 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Thr4Ile Rv0010c_p.Thr4Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 30 75 20816 27393 0.0014391250119927 0.000971175699964354 0.00205380828868033 0.997269550021843 0.996578542380403 0.997851740649204 0.285714285714285 0.201780252928611 0.38211954493837 NA NA NA 0 0 0.0479950640551422 NA NA NA NA 4554 5574 False True 0.526383551114527 0.332531075708367 0.814201029271229 0 0 0.00017719795414655 0.997269550021843 0.996578542380403 0.997851740649204 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 19 56 13355 21257 0.00142066696575444 0.000855544226513897 0.00221766232087821 0.997372495659926 0.996589305975568 0.998014619674392 0.253333333333333 0.159929823015779 0.367005649555813 NA NA NA 0 0 0.0637500966623622 NA NA NA NA 3671 4479 False True 0 1 1 0 0 0 0 0.540037171738781 0.302890182800162 0.923332266973373 0 0 0.000276178961828104 0.997372495659926 0.996589305975568 0.998014619674392 15 5) Not assoc w R New NotAwR yes 5 +Isoniazid Rv0010c p.Thr54Ile Rv0010c_p.Thr54Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Thr64Ile Rv0010c_p.Thr64Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4441 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3566 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Thr64Ser Rv0010c_p.Thr64Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Thr76_Glu125del Rv0010c_p.Thr76_Glu125del 2 inframe_deletion (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4521 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3637 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Trp117fs Rv0010c_p.Trp117fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Trp117Ser Rv0010c_p.Trp117Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 51.349017027227 1 2027.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 62.0933648450895 1 1642.5 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Trp55Arg Rv0010c_p.Trp55Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Trp55* Rv0010c_p.Trp55* 2 stop_gained (see "Genomic_coordinates" sheet) 1 16 1 15 9 30 20837 27438 0.000431737503597812 0.000197436276106449 0.000819413341228355 0.998907820008737 0.998441209231564 0.999262993209016 0.23076923076923 0.111336941104146 0.393261540678467 0.0625 0.00158111172276588 0.302320738434531 0.032258064516129 0.000816370071846613 0.167021116230227 0.0877861496376637 0.00208947966841972 0.570702591305758 0.00189435537734461 87 5574 False False 0.395037673369487 0.164943275266729 0.853742656232591 4.79892504079086e-05 1.21498188904634e-06 0.000267349661612127 0.998907820008737 0.998441209231564 0.999262993209016 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 5 18 13369 21295 0.000373859727830118 0.000121402023062639 0.000872246401868143 0.999155445033547 0.998665566208554 0.999499388823668 0.217391304347826 0.0746034076488037 0.437030726236814 0 0 0.30849710781876 0 0 0.185301968137852 0 0 0.710764630216541 0.00889124814830985 76 4479 False False 0 0 0 0 0 0 0 0.442462246823081 0.128385612384167 1.23693692462116 0 0 0.000275889787465637 0.999155445033547 0.998665566208554 0.999499388823668 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Trp6Arg Rv0010c_p.Trp6Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 118 0 20728 27468 0.00566055838050465 0.0046875697589468 0.00677503755506037 1 0.999865711673152 1 1 0.969221903925855 1 NA NA NA NA NA NA NA NA NA NA 4435 5574 False False Inf 41.7115097641795 Inf 0 0 0.000177950174932775 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 98 0 13276 21313 0.00732765066547031 0.00595282855564683 0.00892289537831692 1 0.999826933785262 1 1 0.963058012964807 1 NA NA NA NA NA NA NA NA NA NA 3560 4479 False False 0 0 0 0 0 0 0 Inf 41.827066989539 Inf 0 0 0.000277822160602089 1 0.999826933785262 1 3 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Trp6* Rv0010c_p.Trp6* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4442 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3567 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Trp73fs Rv0010c_p.Trp73fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4549 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3667 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Tyr135Cys Rv0010c_p.Tyr135Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4505 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Tyr95Cys Rv0010c_p.Tyr95Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 137 701 20709 26767 0.00657200422143336 0.00552041303438725 0.00776452760725898 0.974479394204164 0.972545292539417 0.976312221099204 0.163484486873508 0.139068351708298 0.190293499438872 NA NA NA 0 0 0.00524848850655094 NA NA NA NA 4530 5574 False True 0.252605684821163 0.208613499837118 0.304088597155359 0 0 0.000178113425316683 0.974479394204164 0.972545292539417 0.976312221099204 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 107 494 13267 20819 0.00800059817556452 0.00656118311121995 0.00965983305624262 0.976821658142917 0.974711851120059 0.978799986400017 0.178036605657237 0.148264775482651 0.21101186708824 NA NA NA 0 0 0.00743955579803412 NA NA NA NA 3649 4479 False True 0 1 1 0 0 0 0 0.339894365154904 0.272845093854795 0.4201816566101 0 0 0.000278010601986309 0.976821658142917 0.974711851120059 0.978799986400017 12 5) Not assoc w R New NotAwR yes 5 +Isoniazid Rv0010c p.Val124Leu Rv0010c_p.Val124Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 7.01606985634675 0.509383580255417 1109.5 5574 False False 0.439194051331254 0.00837049629364692 5.4704842261679 0 0 0.000176951454458875 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Val124Met Rv0010c_p.Val124Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 11 0 11 4 19 20842 27449 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999308286005533 0.998920012739518 0.999583493240977 0.17391304347826 0.0495076453057934 0.387811889954797 0 0 0.284914152918154 0 0 0.176466911806965 0 0 0.524817176681831 0.00349729468529113 96 5574 False False 0.277264026585992 0.0686130261256144 0.834493579976384 0 0 0.000176976922618654 0.999308286005533 0.998920012739518 0.999583493240977 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 0 11 2 19 13372 21294 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999108525313189 0.998608200368116 0.999463191365845 0.0952380952380952 0.0117493178844458 0.303774406913924 0 0 0.284914152918154 0 0 0.176466911806965 0 0 0.634627549829372 0.00913141268110905 94 4479 False False 0 0 0 0 0 0 0 0.167624415510808 0.0189392869655141 0.695007241417293 0 0 0.000275827900298067 0.999108525313189 0.998608200368116 0.999463191365845 2 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Val126fs Rv0010c_p.Val126fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4524 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3643 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Val126Glu Rv0010c_p.Val126Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4416 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3542 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Val126Met Rv0010c_p.Val126Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Val21fs Rv0010c_p.Val21fs 2 frameshift (see "Genomic_coordinates" sheet) 1 3 0 3 2 3 20844 27465 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999890782000873 0.99968085216583 0.999977476056514 0.4 0.0527449505263169 0.853367200365326 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18895916093986 0.264083883232833 556.5 5574 False False 0.878430243715217 0.0733354884838472 7.66963698207431 0 0 0.000176959943030976 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 2 3 13372 21310 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999859240838924 0.999588697652472 0.999970971136275 0.4 0.0527449505263169 0.853367200365326 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85709530412199 0.289291791934617 400.5 4479 False False 0 0 0 0 0 0 0 1.06241898494366 0.0886985485353837 9.27715037564111 0 0 0.000275827900298067 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Val21Phe Rv0010c_p.Val21Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Val22Ala Rv0010c_p.Val22Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Val22Leu Rv0010c_p.Val22Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Val22Met Rv0010c_p.Val22Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4550 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Val28Met Rv0010c_p.Val28Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01632529799099 0.509386028876591 1135.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Val38Gly Rv0010c_p.Val38Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4419 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3545 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Val38Met Rv0010c_p.Val38Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Val42Phe Rv0010c_p.Val42Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4428 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3553 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv0010c p.Val99Met Rv0010c_p.Val99Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.1014C>T Rv1129c_c.1014C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.1023G>A Rv1129c_c.1023G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.1026C>T Rv1129c_c.1026C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.1042C>A Rv1129c_c.1042C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.1050C>T Rv1129c_c.1050C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 9 20846 27459 0 0 0.00017694296670111 0.999672346002621 0.99937810218515 0.999850165132458 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.667448724025835 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 9 13374 21304 0 0 0.000275786657608973 0.999577722516773 0.999198537836033 0.999806890245066 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.80720191833017 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.1068C>T Rv1129c_c.1068C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.106C>T Rv1129c_c.106C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.108G>C Rv1129c_c.108G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.18865318395302 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.85651838973546 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.1095G>A Rv1129c_c.1095G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.99604811372315 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.41420404242617 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.-10T>C Rv1129c_c.-10T>C 2 upstream_gene_variant 1254544 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4270 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.-10T>G Rv1129c_c.-10T>G 2 upstream_gene_variant 1254544 1 4 0 4 1 5 20845 27463 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999817970001456 0.999575254267103 0.999940892797913 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.602364635616474 0 0 0.521823750104981 0 0 1.9960711666997 0.139119205469767 335 5574 False False 0.263497241544735 0.00557522895465965 2.35509564487831 0 0 0.000176951454458875 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 1 5 13373 21308 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999765401398207 0.999452610763328 0.999923822225278 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.602364635616474 0 0 0.521823750104981 0 0 2.41427134641658 0.305472044773727 432 4479 False False 0 0 0 0 0 0 0 0.318671950945935 0.00674139558547252 2.84834809554519 0 0 0.000275807277411719 0.999765401398207 0.999452610763328 0.999923822225278 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.1119C>A Rv1129c_c.1119C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.1119C>G Rv1129c_c.1119C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.1125A>C Rv1129c_c.1125A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 6 29 20840 27439 0.000287825002398541 0.000105633792978048 0.000626367784710498 0.998944226008446 0.998484081585802 0.999292821137695 0.171428571428571 0.0656218011562506 0.336498300018197 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.272410483817592 0.0924608392726053 0.66790768270552 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 5 16 13369 21297 0.000373859727830118 0.000121402023062639 0.000872246401868143 0.999249284474264 0.998781170540482 0.999570842259671 0.238095238095238 0.0821758755930225 0.471659827654621 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.497816777619866 0.142596804378312 1.42256762729596 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.1131G>A Rv1129c_c.1131G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.1140C>T Rv1129c_c.1140C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.247471899512553 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.1143G>A Rv1129c_c.1143G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.1164C>A Rv1129c_c.1164C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.1167G>A Rv1129c_c.1167G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.63548263289195 0.137183409715989 155.34952410964 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.1176C>T Rv1129c_c.1176C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.117C>T Rv1129c_c.117C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.1182G>A Rv1129c_c.1182G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.1182G>T Rv1129c_c.1182G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.-11A>C Rv1129c_c.-11A>C 2 upstream_gene_variant 1254545 1 2 0 2 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 7.01547785354097 0.509377906736075 843 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3521 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.120G>A Rv1129c_c.120G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.18865318395302 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.85651838973546 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.1212G>T Rv1129c_c.1212G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.18865318395302 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.85651838973546 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.1215T>C Rv1129c_c.1215T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.18865318395302 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.1216C>T Rv1129c_c.1216C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.247471899512553 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.1221C>T Rv1129c_c.1221C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.1224G>A Rv1129c_c.1224G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.1227C>T Rv1129c_c.1227C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.1233C>T Rv1129c_c.1233C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.1239G>T Rv1129c_c.1239G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.1242C>T Rv1129c_c.1242C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.1248G>C Rv1129c_c.1248G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.1257C>T Rv1129c_c.1257C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.1263G>A Rv1129c_c.1263G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.1269C>A Rv1129c_c.1269C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.99604811372315 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.85651838973546 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.1290C>T Rv1129c_c.1290C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.247471899512553 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.1299C>G Rv1129c_c.1299C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.99604811372315 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.85651838973546 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.1299C>T Rv1129c_c.1299C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.-12A>C Rv1129c_c.-12A>C 2 upstream_gene_variant 1254546 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3458 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.-12A>T Rv1129c_c.-12A>T 2 upstream_gene_variant 1254546 NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4232 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.1302G>A Rv1129c_c.1302G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.1302G>C Rv1129c_c.1302G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 20846 27462 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.11900921779861 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 6 13374 21307 0 0 0.000275786657608973 0.999718481677849 0.999387354605726 0.999896680954833 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.35335561005417 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.1317G>C Rv1129c_c.1317G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.1317G>T Rv1129c_c.1317G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 6 20845 27462 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999781564001747 0.999524617886493 0.999919833755107 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.219573039098105 0.00477770915407814 1.81014820057657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.132A>G Rv1129c_c.132A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.1356A>C Rv1129c_c.1356A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.135C>T Rv1129c_c.135C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.1362G>A Rv1129c_c.1362G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.1389C>T Rv1129c_c.1389C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 5 0 20841 27468 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 1 0.999865711673152 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.20760984683633 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.-13A>C Rv1129c_c.-13A>C 2 upstream_gene_variant 1254547 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.-13A>G Rv1129c_c.-13A>G 2 upstream_gene_variant 1254547 1 2 1 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.31767810026385 0.0167927522337569 103.35711725526 1 1253.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.1404G>A Rv1129c_c.1404G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 2 20843 27466 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999927188000582 0.999737003036386 0.999991182007438 0.6 0.146632799634673 0.947255049473683 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.97663484143357 0.226402568392661 23.6672561646805 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 1 13371 21312 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999953080279641 0.999738608085756 0.999998812096234 0.75 0.194120449683243 0.99369053679029 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.78169172088849 0.383875689805931 250.696170545132 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.1410C>T Rv1129c_c.1410C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.1434T>G Rv1129c_c.1434T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.-15G>A Rv1129c_c.-15G>A 2 upstream_gene_variant 1254549 1 18 1 17 18 41 20828 27427 0.000863475007195625 0.000511827761943967 0.00136432078973001 0.998507354011941 0.997975596204967 0.998928645116862 0.305084745762711 0.191855988212015 0.438662550587621 0.0555555555555555 0.00140555616736942 0.272943599673368 0.0238095238095238 0.000602623301603574 0.125658557174992 0.0774607711338808 0.00185769853426205 0.494461183543784 0.00114177252148301 79 5574 False False 0.578121852852866 0.312519955548464 1.02938330871886 4.8009986077104e-05 1.21550687009947e-06 0.00026746516801679 0.998507354011941 0.997975596204967 0.998928645116862 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 14 1 13 12 34 13362 21279 0.000897263346792283 0.000463712283458933 0.00156681338714949 0.998404729507812 0.997771476125476 0.998894983644582 0.260869565217391 0.14266853688823 0.411318847604362 0.0714285714285714 0.00180678065912538 0.338684489931821 0.0285714285714285 0.000723104376338095 0.149172079656431 0.122500086352803 0.00288645320611938 0.815788383534895 0.013446742586654 96 4479 False False 0 0 0 0 0 0 0 0.56205921973639 0.264939017440717 1.11315874847748 7.48334954725735e-05 1.89461827437637e-06 0.000416874236414112 0.998404729507812 0.997771476125476 0.998894983644582 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.-16T>A Rv1129c_c.-16T>A 2 upstream_gene_variant 1254550 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.-16T>G Rv1129c_c.-16T>G 2 upstream_gene_variant 1254550 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4289 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3438 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.177G>T Rv1129c_c.177G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.-17T>G Rv1129c_c.-17T>G 2 upstream_gene_variant 1254551 1 7 1 6 2 8 20844 27460 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.99970875200233 0.999426206431739 0.999874251669172 0.2 0.0252107263268333 0.556095462307641 0.142857142857142 0.00361029686190058 0.578723197043195 0.111111111111111 0.00280913674659921 0.482496514917337 0.219567581398324 0.00477759051609223 1.81010330762385 0.251121686138721 423 5574 False False 0.329351372097486 0.0340635477373695 1.6506834450398 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 0.99970875200233 0.999426206431739 0.999874251669172 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.85633740727807 0.289259828934126 294 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.183G>T Rv1129c_c.183G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.184C>T Rv1129c_c.184C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.186G>A Rv1129c_c.186G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.18C>T Rv1129c_c.18C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.-18T>G Rv1129c_c.-18T>G 2 upstream_gene_variant 1254552 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4283 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.195T>G Rv1129c_c.195T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.-19T>C Rv1129c_c.-19T>C 2 upstream_gene_variant 1254553 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.-1C>T Rv1129c_c.-1C>T 2 upstream_gene_variant 1254535 1 6 0 6 2 9 20844 27459 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999672346002621 0.99937810218515 0.999850165132458 0.181818181818181 0.0228311982999596 0.517755852360172 0 0 0.4592581264399 0 0 0.336267116879942 0 0 1.11899434969608 0.0402100663742306 187.5 5574 False False 0.292746113989637 0.0307804028975754 1.41460768720699 0 0 0.000176959943030976 0.999672346002621 0.99937810218515 0.999850165132458 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 1 8 13373 21305 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999624642237132 0.999260530264256 0.999837933676441 0.111111111111111 0.00280913674659921 0.482496514917337 0 0 0.521823750104981 0 0 0.369416647552819 0 0 1.73883172202009 0.163959888896549 236 4479 False False 0 0 0 0 0 0 0 0.199141927764899 0.00449176289276445 1.48571302597227 0 0 0.000275807277411719 0.999624642237132 0.999260530264256 0.999837933676441 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.204G>A Rv1129c_c.204G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.211C>T Rv1129c_c.211C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 1 20843 27467 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999963594000291 0.999797175631493 0.999999078280314 0.75 0.194120449683243 0.99369053679029 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.95341361608213 0.31739219148065 207.323829234655 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.216G>A Rv1129c_c.216G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.21A>G Rv1129c_c.21A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 4 20845 27464 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999854376001165 0.999627187086024 0.999960320981843 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.329383545214679 0.00669260119676484 3.32889360843958 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 4 13373 21309 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999812321118566 0.999519537882235 0.999948861529775 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.398358633066626 0.00809276091420046 4.02622197901862 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.-21C>G Rv1129c_c.-21C>G 2 upstream_gene_variant 1254555 NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4239 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3399 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.-21C>T Rv1129c_c.-21C>T 2 upstream_gene_variant 1254555 1 2 0 2 3 3 20843 27465 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999890782000873 0.99968085216583 0.999977476056514 0.5 0.118117248757025 0.881882751242974 0 0 0.841886116991581 0 0 0.707598226178713 0 0 7.01674310006514 0.509390033358317 1167.5 5574 False False 1.31770858321738 0.176469385678871 9.83712695959095 0 0 0.00017696843241753 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 3400 4479 False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 0 0 0.000275827900298067 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.-22A>G Rv1129c_c.-22A>G 2 upstream_gene_variant 1254556 1 1 0 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 51.3533466119536 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.231C>T Rv1129c_c.231C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.-23C>A Rv1129c_c.-23C>A 2 upstream_gene_variant 1254557 1 23 2 21 11 29 20835 27439 0.000527679171063993 0.000263444034397523 0.000943967185544106 0.998944226008446 0.998484081585802 0.999292821137695 0.275 0.146008991963865 0.438882907179048 0.0869565217391304 0.0107099660378758 0.280379335909411 0.064516129032258 0.0079109834618547 0.214216157163402 0.125425394539865 0.0142282355627056 0.513219390405396 0.000499798396065014 66 5574 True False 0.49953907135705 0.225115955290973 1.03037499796058 9.59831069731727e-05 1.1624210921735e-05 0.00034668051841439 0.998944226008446 0.998484081585802 0.999292821137695 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 18 1 17 8 23 13366 21290 0.000598175564528189 0.000258283997825234 0.00117830226263269 0.998920846431755 0.998381177107211 0.999315790080537 0.258064516129032 0.118563995829551 0.446133934334896 0.0555555555555555 0.00140555616736942 0.272943599673368 0.0416666666666666 0.00105435244546974 0.211201683456973 0.0936969131510153 0.00224601275695808 0.598147104531812 0.0027424994365326 64 4479 False False 0 0 0 0 0 0 0 0.554033921240786 0.214212832380371 1.28348394134755 7.48111019675319e-05 1.89405132098963e-06 0.000416749510461935 0.998920846431755 0.998381177107211 0.999315790080537 2 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.-23C>G Rv1129c_c.-23C>G 2 upstream_gene_variant 1254557 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4233 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3393 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.-23C>T Rv1129c_c.-23C>T 2 upstream_gene_variant 1254557 1 5 0 5 0 7 20846 27461 0 0 0.00017694296670111 0.999745158002038 0.999474999027776 0.999897534357495 0 0 0.409616397225003 0 0 0.521823750104981 0 0 0.409616397225003 0 0 1.4377474794477 0.0743318383647099 231 5574 False False 0 0 0.914121240039481 0 0 0.00017694296670111 0.999745158002038 0.999474999027776 0.999897534357495 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 7 13374 21306 0 0 0.000275786657608973 0.99967156195749 0.999323409938814 0.999867941002665 0 0 0.409616397225003 0 0 0.521823750104981 0 0 0.409616397225003 0 0 1.73878331464646 0.163959837077221 234.5 4479 False False 0 0 0 0 0 0 0 0 0 1.10552510564584 0 0 0.000275786657608973 0.99967156195749 0.999323409938814 0.999867941002665 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.246A>G Rv1129c_c.246A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.249G>A Rv1129c_c.249G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.24G>T Rv1129c_c.24G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.-25G>A Rv1129c_c.-25G>A 2 upstream_gene_variant 1254559 1 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4395 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3527 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.264G>A Rv1129c_c.264G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.264G>C Rv1129c_c.264G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.43785249906968 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.41420404242617 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.-26C>T Rv1129c_c.-26C>T 2 upstream_gene_variant 1254560 1 4 0 4 8 5 20838 27463 0.000383766669864722 0.000165697303700768 0.000756032532322191 0.999817970001456 0.999575254267103 0.999940892797913 0.615384615384615 0.315777602914063 0.861420661109839 0 0 0.602364635616474 0 0 0.521823750104981 0 0 1.99674083161788 0.13915331413943 358 5574 False False 2.10868605432383 0.608141362834586 8.19335359905159 0 0 0.000177010891571197 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 6 5 13368 21308 0.000448631673396141 0.000164657143425453 0.000976224581517196 0.999765401398207 0.999452610763328 0.999923822225278 0.545454545454545 0.233793597659345 0.832511905936292 0 0 0.602364635616474 0 0 0.521823750104981 0 0 2.41517517803747 0.305457174040313 422 4479 False False 0 0 0 0 0 0 0 1.91274685816876 0.486259240069532 7.92430176367559 0 0 0.00027591042269331 0.999765401398207 0.999452610763328 0.999923822225278 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.-27C>T Rv1129c_c.-27C>T 2 upstream_gene_variant 1254561 1 2 0 2 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 7.01573328293188 0.509380354735251 864 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.282C>T Rv1129c_c.282C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.-28delTinsCC Rv1129c_c.-28delTinsCC 2 upstream_gene_variant 1254562 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4383 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.-28T>C Rv1129c_c.-28T>C 2 upstream_gene_variant 1254562 NA 0 0 0 12013 12820 8833 14648 0.576273625635613 0.569531376396524 0.58299459601215 0.533275083733799 0.527353775167048 0.53918935160243 0.483751459751137 0.477518060946813 0.489988662152501 NA NA NA 0 0 0.000287702712819987 NA NA NA NA 4331 5574 False True 1.55393751943896 1.49824976077341 1.61165785859818 0 0 0.000417537561150784 0.533275083733799 0.527353775167048 0.53918935160243 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 7551 9795 5823 11518 0.564602960969044 0.556149325539455 0.573028472871125 0.540421339088819 0.533702040308471 0.547129609179553 0.435316499481148 0.427920784344072 0.442733910336901 NA NA NA 0 0 0.000376537509931538 NA NA NA NA 3477 4479 False True 0 1 1 0 0 0 0 1.52486120019913 1.45960027658522 1.59307904914225 0 0 0.000633300917982308 0.540421339088819 0.533702040308471 0.547129609179553 2612 5) Not assoc w R New NotAwR yes 5 +Isoniazid Rv1129c c.294G>A Rv1129c_c.294G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.-29A>G Rv1129c_c.-29A>G 2 upstream_gene_variant 1254563 NA 0 0 0 0 68 20846 27400 0 0 0.00017694296670111 0.997524392019804 0.99686261748086 0.998077096387274 0 0 0.0528030427936397 NA NA NA 0 0 0.0528030427936397 NA NA NA NA 4265 5574 False True 0 0 0.0732664765531169 0 0 0.00017694296670111 0.997524392019804 0.99686261748086 0.998077096387274 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 65 13374 21248 0 0 0.000275786657608973 0.996950218176699 0.99611443105232 0.997645478090083 0 0 0.0551716343188133 NA NA NA 0 0 0.0551716343188133 NA NA NA NA 3421 4479 False True 1 1 1 0 0 0 0 0 0 0.0927931052004246 0 0 0.000275786657608973 0.996950218176699 0.99611443105232 0.997645478090083 NA 5) Not assoc w R New NotAwR yes 5 +Isoniazid Rv1129c c.-2A>C Rv1129c_c.-2A>C 2 upstream_gene_variant 1254536 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.-2A>G Rv1129c_c.-2A>G 2 upstream_gene_variant 1254536 1 4 0 4 1 4 20845 27464 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999854376001165 0.999627187086024 0.999960320981843 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 1.99614374716563 0.139122901336525 342.5 5574 False False 0.329383545214679 0.00669260119676484 3.32889360843958 0 0 0.000176951454458875 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 3 13373 21310 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999859240838924 0.999588697652472 0.999970971136275 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85680682534852 0.289279625558287 389.5 4479 False False 0 0 0 0 0 0 0 0.531169769934445 0.010122018243966 6.61631049307563 0 0 0.000275807277411719 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.303C>T Rv1129c_c.303C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.306C>T Rv1129c_c.306C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.309C>T Rv1129c_c.309C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.-31T>C Rv1129c_c.-31T>C 2 upstream_gene_variant 1254565 1 3 1 2 3 4 20843 27464 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999854376001165 0.999627187086024 0.999960320981843 0.428571428571428 0.0989882784425078 0.815948432359917 0.333333333333333 0.00840375865961264 0.905700675949754 0.2 0.00505076337946806 0.716417936118089 0.658830302739528 0.0111721139325435 12.6570329596507 1 2027.5 5574 False False 0.988245454109293 0.144734627190883 5.84310835075667 4.79754365764728e-05 1.21463215353938e-06 0.000267272712750976 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 3 2 13371 21311 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999906160559283 0.999661061221376 0.999988635406343 0.6 0.146632799634673 0.947255049473683 1 0.025 1 0.333333333333333 0.00840375865961264 0.905700675949754 Inf 0.0408639663223947 Inf 0.385549116281751 530 4479 False False 0 0 0 0 0 0 0 2.39073367736145 0.273835790357664 28.6284716983702 7.47831289261142e-05 1.89334310623943e-06 0.000416593707936992 0.999906160559283 0.999661061221376 0.999988635406343 2 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.-31T>G Rv1129c_c.-31T>G 2 upstream_gene_variant 1254565 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.327C>T Rv1129c_c.327C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.-32C>T Rv1129c_c.-32C>T 2 upstream_gene_variant 1254566 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.334C>A Rv1129c_c.334C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.336G>C Rv1129c_c.336G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.345G>A Rv1129c_c.345G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.369G>A Rv1129c_c.369G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.-36T>C Rv1129c_c.-36T>C 2 upstream_gene_variant 1254570 1 2 0 2 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 7.01573328293188 0.509380354735251 864 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.48495357236853 0.526173219289417 690 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.-37G>A Rv1129c_c.-37G>A 2 upstream_gene_variant 1254571 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4240 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.-38T>A Rv1129c_c.-38T>A 2 upstream_gene_variant 1254572 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.-38T>C Rv1129c_c.-38T>C 2 upstream_gene_variant 1254572 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.390C>T Rv1129c_c.390C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.18865318395302 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.85651838973546 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.39T>C Rv1129c_c.39T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.544526627735454 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.-3A>G Rv1129c_c.-3A>G 2 upstream_gene_variant 1254537 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.3G>A Rv1129c_c.3G>A 2 initiator_codon_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 16 20845 27452 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.99941750400466 0.999054234895718 0.999667017718464 0.0588235294117647 0.00148817439126663 0.28688939666722 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.0823099064523866 0.00196698357180464 0.529947121754166 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 13 13373 21300 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.99939004363534 0.998957181904114 0.999675185224884 0.0714285714285714 0.00180678065912538 0.338684489931821 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.122520118033465 0.00288692459724197 0.815921595502421 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.3G>T Rv1129c_c.3G>T 2 initiator_codon_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.-40T>G Rv1129c_c.-40T>G 2 upstream_gene_variant 1254574 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4373 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.411C>T Rv1129c_c.411C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.-41T>C Rv1129c_c.-41T>C 2 upstream_gene_variant 1254575 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.426C>T Rv1129c_c.426C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.43785249906968 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 5 13374 21308 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.73894646374006 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.-42C>A Rv1129c_c.-42C>A 2 upstream_gene_variant 1254576 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.-42C>T Rv1129c_c.-42C>T 2 upstream_gene_variant 1254576 1 3 0 3 3 8 20843 27460 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.99970875200233 0.999426206431739 0.999874251669172 0.272727272727272 0.0602177341729066 0.609742559572421 0 0 0.707598226178713 0 0 0.369416647552819 0 0 3.18853160626062 0.264070356723789 434.5 5574 False False 0.494050760447152 0.0844081742669313 2.05877344876832 0 0 0.00017696843241753 0.99970875200233 0.999426206431739 0.999874251669172 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 2 6 13372 21307 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999718481677849 0.999387354605726 0.999896680954833 0.25 0.0318540262499442 0.650855794412824 0 0 0.841886116991581 0 0 0.4592581264399 0 0 8.48502807257935 0.526174169337158 701 4479 False False 0 0 0 0 0 0 0 0.531134709342905 0.0524216694068566 2.97088164447145 0 0 0.000275827900298067 0.999718481677849 0.999387354605726 0.999896680954833 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.-42delC Rv1129c_c.-42delC 2 upstream_gene_variant 1254575 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4284 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.435C>T Rv1129c_c.435C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.18865318395302 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.85651838973546 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.-43A>G Rv1129c_c.-43A>G 2 upstream_gene_variant 1254577 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.-43A>T Rv1129c_c.-43A>T 2 upstream_gene_variant 1254577 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.-44T>C Rv1129c_c.-44T>C 2 upstream_gene_variant 1254578 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4245 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.456G>A Rv1129c_c.456G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.-45G>T Rv1129c_c.-45G>T 2 upstream_gene_variant 1254579 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.-46C>G Rv1129c_c.-46C>G 2 upstream_gene_variant 1254580 1 36 0 36 38 52 20808 27416 0.00182289168185743 0.00129029962509865 0.00250121141611544 0.998106888015144 0.997518167363423 0.998585820163089 0.422222222222222 0.318775582044042 0.530933774023416 0 0 0.0973937559144919 0 0 0.0684822087033195 0 0 0.142196907965535 2.71527804479479e-09 20 5574 True False 0.962839736196137 0.616286136299239 1.49198809125288 0 0 0.000177266074964553 0.998106888015144 0.997518167363423 0.998585820163089 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 29 0 29 19 43 13355 21270 0.00142066696575444 0.000855544226513897 0.00221766232087821 0.997982452024586 0.997283327625553 0.998539517561132 0.306451612903225 0.195614040372819 0.436502584703898 0 0 0.119444869069502 0 0 0.0822111211541385 0 0 0.216106162953688 8.99311456262853e-07 20 4479 True False 0 0 0 0 0 0 0 0.703734338676395 0.38713618387043 1.23435490226998 0 0 0.000276178961828104 0.997982452024586 0.997283327625553 0.998539517561132 3 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.-46C>T Rv1129c_c.-46C>T 2 upstream_gene_variant 1254580 1 8 1 7 1 10 20845 27458 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999635940002912 0.999330582956894 0.999825405716755 0.0909090909090909 0.00229897221381426 0.412779916988382 0.125 0.0031597235312519 0.526509670875206 0.0909090909090909 0.00229897221381426 0.412779916988382 0.188178048864064 0.00417944448617375 1.46497317072161 0.149407941208467 365 5574 False False 0.131724634204845 0.00303942055735959 0.926075505001071 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999635940002912 0.999330582956894 0.999825405716755 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 1 6 1 8 13373 21305 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999624642237132 0.999260530264256 0.999837933676441 0.111111111111111 0.00280913674659921 0.482496514917337 0.142857142857142 0.00361029686190058 0.578723197043195 0.111111111111111 0.00280913674659921 0.482496514917337 0.265522570353199 0.00577631913992687 2.18892004102371 0.261184325744273 275 4479 False False 0 0 0 0 0 0 0 0.199141927764899 0.00449176289276445 1.48571302597227 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999624642237132 0.999260530264256 0.999837933676441 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.-47G>A Rv1129c_c.-47G>A 2 upstream_gene_variant 1254581 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.-47G>C Rv1129c_c.-47G>C 2 upstream_gene_variant 1254581 1 0 0 0 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4301 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3450 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.480C>T Rv1129c_c.480C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 7 21 20839 27447 0.000335795836131632 0.000135017659185429 0.000691744589626827 0.999235474006116 0.998831576963824 0.999526686034611 0.25 0.106907991829226 0.448715451528608 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.439032583137386 0.157630470926832 1.07231975796666 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 5 13 13369 21300 0.000373859727830118 0.000121402023062639 0.000872246401868143 0.99939004363534 0.998957181904114 0.999675185224884 0.277777777777777 0.0969492125255593 0.534801965583056 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.612783880043959 0.171038062026926 1.832174095132 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.-48A>C Rv1129c_c.-48A>C 2 upstream_gene_variant 1254582 NA 0 0 0 114 319 20732 27149 0.00546867504557229 0.0045130379260202 0.00656592963922967 0.988386486092908 0.98704827807062 0.989619830723381 0.263279445727482 0.222382199791893 0.307445334164223 NA NA NA 0 0 0.0114972806966447 NA NA NA NA 4377 5574 False True 0.467979474735647 0.374183495917424 0.581825187320254 0 0 0.000177915844555789 0.988386486092908 0.98704827807062 0.989619830723381 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 94 280 13280 21033 0.00702856288320622 0.00568342037824346 0.00859440974968783 0.986862478299629 0.98524215198055 0.988347912519279 0.251336898395721 0.20815760433554 0.298501887066815 NA NA NA 0 0 0.0130881647032966 NA NA NA NA 3511 4479 False True 0 1 1 0 0 0 0 0.531707723752151 0.415918504798782 0.674695856057167 0 0 0.000277738490850259 0.986862478299629 0.98524215198055 0.988347912519279 4 5) Not assoc w R New NotAwR yes 5 +Isoniazid Rv1129c c.-48A>G Rv1129c_c.-48A>G 2 upstream_gene_variant 1254582 NA 0 0 0 58 271 20788 27197 0.00278230835651923 0.00211338064309473 0.00359531342928037 0.990133974078928 0.988893611585485 0.991268935519545 0.176291793313069 0.136672396215806 0.221852953800511 NA NA NA 0 0 0.0135198755918736 NA NA NA NA 4222 5574 False True 0.280005779661414 0.206994209770327 0.37325506873119 0 0 0.000177436606374299 0.990133974078928 0.988893611585485 0.991268935519545 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 43 236 13331 21077 0.00321519365933901 0.0023277991690822 0.00432842794483404 0.988926945995402 0.987429899170411 0.990288295066777 0.154121863799283 0.113838962270548 0.20193354130353 NA NA NA 0 0 0.0155093175017574 NA NA NA NA 3385 4479 False True 0 1 1 0 0 0 0 0.288072976330179 0.20295672935975 0.400363488432062 0 0 0.000276676102181712 0.988926945995402 0.987429899170411 0.990288295066777 45 5) Not assoc w R New NotAwR yes 5 +Isoniazid Rv1129c c.-48dupA Rv1129c_c.-48dupA 2 upstream_gene_variant 1254581 1 10 0 10 5 16 20841 27452 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.99941750400466 0.999054234895718 0.999667017718464 0.238095238095238 0.0821758755930225 0.471659827654621 0 0 0.30849710781876 0 0 0.205907214207822 0 0 0.587738276291456 0.00669306788602144 112 5574 False False 0.41162852070438 0.117919353180591 1.17616362264663 0 0 0.000176985413634466 0.99941750400466 0.999054234895718 0.999667017718464 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 4 9 13370 21304 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 0.999577722516773 0.999198537836033 0.999806890245066 0.307692307692307 0.0909203945720966 0.614261661750705 0 0 0.602364635616474 0 0 0.336267116879942 0 0 2.41435990401259 0.305470578869423 429 4479 False False 0 0 0 0 0 0 0 0.708185822321947 0.159332029437241 2.53803747045701 0 0 0.000275869155324334 0.999577722516773 0.999198537836033 0.999806890245066 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.48G>A Rv1129c_c.48G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.-49A>C Rv1129c_c.-49A>C 2 upstream_gene_variant 1254583 NA 0 0 0 72 257 20774 27211 0.0034539000287825 0.00270341567055964 0.00434766641670911 0.99064365807485 0.989433490734791 0.991748258967049 0.218844984802431 0.175356123195513 0.267476560129703 NA NA NA 0 0 0.0142510945057822 NA NA NA NA 4363 5574 False True 0.366964242567501 0.278363661737184 0.478606391160407 0 0 0.000177556173715275 0.99064365807485 0.989433490734791 0.991748258967049 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 51 229 13323 21084 0.0038133692238672 0.00284058219005207 0.00501086513450784 0.989255384037911 0.987779015807487 0.990595920088179 0.182142857142857 0.138727833985209 0.23242926678126 NA NA NA 0 0 0.0159795935713575 NA NA NA NA 3502 4479 False True 0 1 1 0 0 0 0 0.35244039021071 0.254684739740874 0.479634073341939 0 0 0.000276842213598562 0.989255384037911 0.987779015807487 0.990595920088179 7 5) Not assoc w R New NotAwR yes 5 +Isoniazid Rv1129c c.-49A>G Rv1129c_c.-49A>G 2 upstream_gene_variant 1254583 1 1 0 1 3 4 20843 27464 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999854376001165 0.999627187086024 0.999960320981843 0.428571428571428 0.0989882784425078 0.815948432359917 0 0 0.975 0 0 0.602364635616474 0 0 51.3502039740317 1 2027.5 5574 False False 0.988245454109293 0.144734627190883 5.84310835075667 0 0 0.00017696843241753 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 4 13372 21309 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999812321118566 0.999519537882235 0.999948861529775 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.975 0 0 0.602364635616474 0 0 62.0921820140823 1 1642.5 4479 False False 0 0 0 0 0 0 0 0.796776847143284 0.0720475461928349 5.56077695166295 0 0 0.000275827900298067 0.999812321118566 0.999519537882235 0.999948861529775 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.-4G>A Rv1129c_c.-4G>A 2 upstream_gene_variant 1254538 NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4254 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3411 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.-4G>T Rv1129c_c.-4G>T 2 upstream_gene_variant 1254538 1 1 0 1 2 3 20844 27465 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999890782000873 0.99968085216583 0.999977476056514 0.4 0.0527449505263169 0.853367200365326 0 0 0.975 0 0 0.707598226178713 0 0 51.3496104721628 1 2027.5 5574 False False 0.878430243715217 0.0733354884838472 7.66963698207431 0 0 0.000176959943030976 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 3 13372 21310 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999859240838924 0.999588697652472 0.999970971136275 0.4 0.0527449505263169 0.853367200365326 0 0 0.975 0 0 0.707598226178713 0 0 62.0950929450045 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.06241898494366 0.0886985485353837 9.27715037564111 0 0 0.000275827900298067 0.999859240838924 0.999588697652472 0.999970971136275 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.510C>T Rv1129c_c.510C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.519C>T Rv1129c_c.519C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.540T>C Rv1129c_c.540T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.552G>A Rv1129c_c.552G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.567A>G Rv1129c_c.567A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.570G>A Rv1129c_c.570G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.576C>A Rv1129c_c.576C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.57T>C Rv1129c_c.57T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.591G>C Rv1129c_c.591G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 13 20846 27455 0 0 0.00017694296670111 0.999526722003786 0.99919081619501 0.999747976101462 0 0 0.24705263800047 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.432228279580125 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 13 13374 21300 0 0 0.000275786657608973 0.99939004363534 0.998957181904114 0.999675185224884 0 0 0.24705263800047 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.522684266329562 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.597G>A Rv1129c_c.597G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.615G>A Rv1129c_c.615G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.627T>C Rv1129c_c.627T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.636G>A Rv1129c_c.636G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.642C>T Rv1129c_c.642C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.658815063564403 0.011171855707321 12.6567401482543 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.648C>G Rv1129c_c.648C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.63548263289195 0.137183409715989 155.34952410964 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.651G>A Rv1129c_c.651G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.654C>T Rv1129c_c.654C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.660C>T Rv1129c_c.660C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.663C>T Rv1129c_c.663C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.678C>T Rv1129c_c.678C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.658815063564403 0.011171855707321 12.6567401482543 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.682C>A Rv1129c_c.682C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.684G>C Rv1129c_c.684G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.-6G>A Rv1129c_c.-6G>A 2 upstream_gene_variant 1254540 1 7 0 7 5 19 20841 27449 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.999308286005533 0.998920012739518 0.999583493240977 0.208333333333333 0.0713186171980549 0.421512843637252 0 0 0.409616397225003 0 0 0.176466911806965 0 0 0.913941112244464 0.0219656821385285 150 5574 False False 0.346596662954348 0.101143506910399 0.959912718392501 0 0 0.000176985413634466 0.999308286005533 0.998920012739518 0.999583493240977 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 2 18 13372 21295 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999155445033547 0.998665566208554 0.999499388823668 0.1 0.0123485271702948 0.316982714019082 0 0 0.4592581264399 0 0 0.185301968137852 0 0 1.35279601530545 0.0884698944602502 151 4479 False False 0 0 0 0 0 0 0 0.176945192275733 0.01991301537096 0.73929455480427 0 0 0.000275827900298067 0.999155445033547 0.998665566208554 0.999499388823668 2 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.70C>A Rv1129c_c.70C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 7 20845 27461 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999745158002038 0.999474999027776 0.999897534357495 0.125 0.0031597235312519 0.526509670875206 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.188198608779083 0.00417990056987037 1.46513319151887 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 6 13374 21307 0 0 0.000275786657608973 0.999718481677849 0.999387354605726 0.999896680954833 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.35335561005417 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.736C>T Rv1129c_c.736C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 8 20845 27460 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.99970875200233 0.999426206431739 0.999874251669172 0.111111111111111 0.00280913674659921 0.482496514917337 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.164667786039817 0.00371513512243138 1.22846047298172 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 6 13373 21307 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999718481677849 0.999387354605726 0.999896680954833 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.265547496198808 0.00577686092206708 2.18912593855065 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.741G>C Rv1129c_c.741G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.742C>T Rv1129c_c.742C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.753G>A Rv1129c_c.753G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.756A>C Rv1129c_c.756A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.777G>A Rv1129c_c.777G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.7C>A Rv1129c_c.7C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.544526627735454 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.807C>T Rv1129c_c.807C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.816C>T Rv1129c_c.816C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.828A>C Rv1129c_c.828A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.831G>C Rv1129c_c.831G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.852C>T Rv1129c_c.852C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.858G>A Rv1129c_c.858G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.18865318395302 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.85651838973546 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.861C>T Rv1129c_c.861C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.864C>A Rv1129c_c.864C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 5 20843 27463 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999817970001456 0.999575254267103 0.999940892797913 0.375 0.0852334141372535 0.755136783633448 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.790567576644437 0.122780413850952 4.06394022809159 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 5 13372 21308 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999765401398207 0.999452610763328 0.999923822225278 0.285714285714285 0.0366925661760855 0.709579136262657 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.637391564463057 0.0606680462541562 3.89402937569226 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.888A>C Rv1129c_c.888A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.894G>A Rv1129c_c.894G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.-8T>C Rv1129c_c.-8T>C 2 upstream_gene_variant 1254542 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4302 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3451 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.-8T>G Rv1129c_c.-8T>G 2 upstream_gene_variant 1254542 1 5 0 5 6 5 20840 27463 0.000287825002398541 0.000105633792978048 0.000626367784710498 0.999817970001456 0.999575254267103 0.999940892797913 0.545454545454545 0.233793597659345 0.832511905936292 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.43826774174581 0.0743627342674351 273 5574 False False 1.58136276391554 0.402037805145704 6.55169187240669 0 0 0.000176993905465082 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 4 5 13370 21308 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 0.999765401398207 0.999452610763328 0.999923822225278 0.444444444444444 0.136995662265166 0.787991493221131 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.73946658058257 0.163960627554926 267 4479 False False 0 0 0 0 0 0 0 1.27497382198952 0.252954323547563 5.92545609271499 0 0 0.000275869155324334 0.999765401398207 0.999452610763328 0.999923822225278 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.903T>C Rv1129c_c.903T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 2 20844 27466 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999927188000582 0.999737003036386 0.999991182007438 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.3176933410094 0.0955278435529395 18.1762534351792 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 2 13372 21311 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999906160559283 0.999661061221376 0.999988635406343 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59370326054442 0.115491055908661 21.9865025501046 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.90G>A Rv1129c_c.90G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.915G>T Rv1129c_c.915G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.43785249906968 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.918G>A Rv1129c_c.918G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.927G>A Rv1129c_c.927G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.927G>C Rv1129c_c.927G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.936G>A Rv1129c_c.936G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 8 20846 27460 0 0 0.00017694296670111 0.99970875200233 0.999426206431739 0.999874251669172 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.771808536885009 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 7 13374 21306 0 0 0.000275786657608973 0.99967156195749 0.999323409938814 0.999867941002665 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.10552510564584 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.939C>A Rv1129c_c.939C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.948C>G Rv1129c_c.948C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.957C>T Rv1129c_c.957C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.960G>A Rv1129c_c.960G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.969A>G Rv1129c_c.969A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 19 80 20827 27388 0.000911445840928715 0.000548836318218138 0.00142297127227785 0.997087520023299 0.996376458242384 0.997689929573139 0.191919191919191 0.119684354393664 0.283367629217074 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.312318144715993 0.178726997641545 0.520180251033156 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 11 47 13363 21266 0.000822491401226259 0.000410653977896139 0.00147118664271154 0.997794773143152 0.997068582412381 0.998379246067552 0.189655172413793 0.0986638168420868 0.314050861593841 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.372457452381217 0.174146310161706 0.728941425014472 NA NA NA NA NA NA 19 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.975G>A Rv1129c_c.975G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.978C>T Rv1129c_c.978C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.982C>A Rv1129c_c.982C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.247471899512553 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.987G>A Rv1129c_c.987G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.993G>A Rv1129c_c.993G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.996A>C Rv1129c_c.996A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.9G>A Rv1129c_c.9G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.9G>T Rv1129c_c.9G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 14 20843 27454 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999490316004077 0.999144984581285 0.999721323894632 0.176470588235294 0.0379850680706259 0.434317872844283 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.282253034591949 0.0520075201100098 1.01151794801423 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 11 13373 21302 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999483883076056 0.999076712346733 0.999742329032819 0.0833333333333333 0.00210759323186022 0.384796165150944 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.144810099046246 0.00336819644582784 0.996572767671761 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1129c c.-9T>A Rv1129c_c.-9T>A 2 upstream_gene_variant 1254543 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c c.-9T>G Rv1129c_c.-9T>G 2 upstream_gene_variant 1254543 NA 0 0 0 138 702 20708 26766 0.00661997505516645 0.00556440579584491 0.00781644886714438 0.974442988204456 0.972507596395575 0.976277113902724 0.164285714285714 0.139845925321229 0.191106786098468 NA NA NA 0 0 0.00524103165377165 NA NA NA NA 4215 5574 False True 0.254089835217901 0.209956658014928 0.305674246255587 0 0 0.000178122025739776 0.974442988204456 0.972507596395575 0.976277113902724 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 109 511 13265 20802 0.00815014206669657 0.00669675501219846 0.00982322017424863 0.976024022896823 0.973880730051758 0.978036089099618 0.175806451612903 0.14663954359445 0.20809925028264 NA NA NA 0 0 0.00719294820444105 NA NA NA NA 3378 4479 False True 0 1 1 0 0 0 0 0.334505632954016 0.269143874848531 0.412608125771112 0 0 0.000278052512570196 0.976024022896823 0.973880730051758 0.978036089099618 11 5) Not assoc w R New NotAwR yes 5 +Isoniazid Rv1129c LoF Rv1129c_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 3 0 3 10 7 20836 27461 0.000479708337330902 0.000230061997553563 0.000882023176671562 0.999745158002038 0.999474999027776 0.999897534357495 0.588235294117647 0.329247153946757 0.815563038216053 0 0 0.707598226178713 0 0 0.409616397225003 0 0 3.18971904815445 0.264107928111881 571 5574 False False 1.88279900172777 0.646806021341061 5.82812930745027 0 0 0.000177027880937939 0.999745158002038 0.999474999027776 0.999897534357495 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 5 3 13369 21310 0.000373859727830118 0.000121402023062639 0.000872246401868143 0.999859240838924 0.999588697652472 0.999970971136275 0.625 0.244863216366551 0.914766585862746 0 0 0.975 0 0 0.707598226178713 0 0 62.1090135447252 1 1642.5 4479 False False 0 0 0 0 0 0 0 2.65664347869449 0.516758123120163 17.1115025092299 0 0 0.000275889787465637 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ala100Thr Rv1129c_p.Ala100Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 0 8 20846 27460 0 0 0.00017694296670111 0.99970875200233 0.999426206431739 0.999874251669172 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.771808536885009 0.0121106507453556 124 5574 False False 0 0 0.771808536885009 0 0 0.00017694296670111 0.99970875200233 0.999426206431739 0.999874251669172 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 0 8 13374 21305 0 0 0.000275786657608973 0.999624642237132 0.999260530264256 0.999837933676441 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.93343997011793 0.0270142859619197 118.5 4479 False False 0 0 0 0 0 0 0 0 0 0.93343997011793 0 0 0.000275786657608973 0.999624642237132 0.999260530264256 0.999837933676441 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ala104Thr Rv1129c_p.Ala104Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0337875782094303 Inf 0.431457371721896 645 5574 False False Inf 0.247471899512553 Inf 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ala10Val Rv1129c_p.Ala10Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4357 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3498 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ala111Gly Rv1129c_p.Ala111Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4396 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ala111Thr Rv1129c_p.Ala111Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ala129Pro Rv1129c_p.Ala129Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4234 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3394 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 2 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ala130Pro Rv1129c_p.Ala130Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 4384 5574 False False Inf 0.869878292971449 Inf 0 0 0.000176976922618654 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3517 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ala130Val Rv1129c_p.Ala130Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4402 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3532 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ala141Thr Rv1129c_p.Ala141Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4241 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ala150Thr Rv1129c_p.Ala150Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4323 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3471 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ala150Val Rv1129c_p.Ala150Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ala195Pro Rv1129c_p.Ala195Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 7 0 20839 27468 0.000335795836131632 0.000135017659185429 0.000691744589626827 1 0.999865711673152 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 4378 5574 False False Inf 1.89951899263229 Inf 0 0 0.00017700239811062 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3512 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ala195Ser Rv1129c_p.Ala195Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4242 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3401 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ala20Thr Rv1129c_p.Ala20Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4216 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3379 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ala216Pro Rv1129c_p.Ala216Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4271 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ala230Ser Rv1129c_p.Ala230Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4297 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3445 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ala230Thr Rv1129c_p.Ala230Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 5 4 20841 27464 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.999854376001165 0.999627187086024 0.999960320981843 0.555555555555555 0.212008506778868 0.863004337734833 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.18930211236502 0.264094733817729 565.5 5574 False False 1.64723381795499 0.354499279020611 8.30243796120459 0 0 0.000176985413634466 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 2 4 13372 21309 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999812321118566 0.999519537882235 0.999948861529775 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.85691429457185 0.289284157000631 397 4479 False False 0 0 0 0 0 0 0 0.796776847143284 0.0720475461928349 5.56077695166295 0 0 0.000275827900298067 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ala239Thr Rv1129c_p.Ala239Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4298 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3446 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ala239Val Rv1129c_p.Ala239Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 51.3533466119536 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ala269Ser Rv1129c_p.Ala269Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ala296Gly Rv1129c_p.Ala296Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4272 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3427 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ala342Ser Rv1129c_p.Ala342Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ala351Val Rv1129c_p.Ala351Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 1 20843 27467 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999963594000291 0.999797175631493 0.999999078280314 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 51.3558084523276 1 2027.5 5574 False False 3.95341361608213 0.31739219148065 207.323829234655 0 0 0.00017696843241753 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3491 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ala353Gly Rv1129c_p.Ala353Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4337 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3482 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ala373Thr Rv1129c_p.Ala373Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 6 20846 27462 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 1.43779998918648 0.0743349556518805 235.5 5574 False False 0 0 1.11900921779861 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 6 13374 21307 0 0 0.000275786657608973 0.999718481677849 0.999387354605726 0.999896680954833 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 1.73886488920615 0.163959928472831 238.5 4479 False False 0 0 0 0 0 0 0 0 0 1.35335561005417 0 0 0.000275786657608973 0.999718481677849 0.999387354605726 0.999896680954833 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ala383Glu Rv1129c_p.Ala383Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 3 5 20843 27463 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999817970001456 0.999575254267103 0.999940892797913 0.375 0.0852334141372535 0.755136783633448 0 0 0.707598226178713 0 0 0.521823750104981 0 0 3.18887994537459 0.26408137621925 553 5574 False False 0.790567576644437 0.122780413850952 4.06394022809159 0 0 0.00017696843241753 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 3 13371 21310 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999859240838924 0.999588697652472 0.999970971136275 0.5 0.118117248757025 0.881882751242974 0 0 0.975 0 0 0.707598226178713 0 0 62.0997324515157 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59374766285244 0.213424225946693 11.9045637110481 0 0 0.000275848526268708 0.999859240838924 0.999588697652472 0.999970971136275 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ala383Ser Rv1129c_p.Ala383Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4273 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3428 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ala383Thr Rv1129c_p.Ala383Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 51.3446878573018 1 2027.5 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ala383Val Rv1129c_p.Ala383Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ala400Ser Rv1129c_p.Ala400Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ala400Thr Rv1129c_p.Ala400Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 22 0 22 12 26 20834 27442 0.000575650004797083 0.000297481006307132 0.00100532857413147 0.999053444007572 0.998613381560132 0.999381587946625 0.31578947368421 0.175025338901126 0.486527054406021 0 0 0.154372512815574 0 0 0.132274604497754 0 0 0.24049638662078 8.00190479041628e-06 44 5574 True False 0.607926392509285 0.279382829237504 1.24841238145711 0 0 0.000177044873566246 0.999053444007572 0.998613381560132 0.999381587946625 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 22 0 22 3 24 13371 21289 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.998873926711396 0.998324952535764 0.99927837451873 0.111111111111111 0.0235274543808539 0.291586924273551 0 0 0.154372512815574 0 0 0.142473597722525 0 0 0.290734774024241 2.74699865254796e-05 32 4479 True False 0 0 0 0 0 0 0 0.19902213746167 0.0383576358789959 0.655585626970656 0 0 0.000275848526268708 0.998873926711396 0.998324952535764 0.99927837451873 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ala445Pro Rv1129c_p.Ala445Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4364 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3503 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ala445Thr Rv1129c_p.Ala445Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4385 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ala456Val Rv1129c_p.Ala456Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4365 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ala468Thr Rv1129c_p.Ala468Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 51.3533466119536 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 62.1009148060541 1 1642.5 4479 False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 0 0 0.000275827900298067 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ala473Thr Rv1129c_p.Ala473Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ala73Thr Rv1129c_p.Ala73Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 0 0 0.841886116991581 0 0 0.521823750104981 0 0 7.01522242414976 0.509375458954636 835.5 5574 False False 0 0 1.43785249906968 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 62.0829055149378 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ala82Thr Rv1129c_p.Ala82Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4246 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3404 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Arg112Gln Rv1129c_p.Arg112Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4310 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3459 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Arg112Trp Rv1129c_p.Arg112Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Arg126Trp Rv1129c_p.Arg126Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 4 6 20842 27462 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999781564001747 0.999524617886493 0.999919833755107 0.4 0.121552258119827 0.737621923393055 0 0 0.602364635616474 0 0 0.4592581264399 0 0 1.99628552056873 0.139130119793297 352 5574 False False 0.878418577871605 0.182308638457443 3.70497296035774 0 0 0.000176976922618654 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 4 2 13370 21311 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 0.999906160559283 0.999661061221376 0.999988635406343 0.666666666666666 0.222778095503512 0.956728131707258 0 0 0.975 0 0 0.841886116991581 0 0 62.107284016625 1 1642.5 4479 False False 0 0 0 0 0 0 0 3.18788332086761 0.456775580099959 35.246992707007 0 0 0.000275869155324334 0.999906160559283 0.999661061221376 0.999988635406343 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Arg140His Rv1129c_p.Arg140His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Arg140Pro Rv1129c_p.Arg140Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4386 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3518 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Arg151Gln Rv1129c_p.Arg151Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Arg165His Rv1129c_p.Arg165His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Arg165Leu Rv1129c_p.Arg165Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Arg201Gln Rv1129c_p.Arg201Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4349 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Arg201Trp Rv1129c_p.Arg201Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Arg228Trp Rv1129c_p.Arg228Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Arg238Cys Rv1129c_p.Arg238Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 8 0 20838 27468 0.000383766669864722 0.000165697303700768 0.000756032532322191 1 0.999865711673152 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 4306 5574 False False Inf 2.24970730189478 Inf 0 0 0.000177010891571197 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 8 0 13366 21313 0.000598175564528189 0.000258283997825234 0.00117830226263269 1 0.999826933785262 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 3454 4479 False False 0 0 0 0 0 0 0 Inf 2.72130996382454 Inf 0 0 0.000275951702410535 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Arg274Pro Rv1129c_p.Arg274Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4338 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3483 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Arg290His Rv1129c_p.Arg290His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Arg294Cys Rv1129c_p.Arg294Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 6 20845 27462 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999781564001747 0.999524617886493 0.999919833755107 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.975 0 0 0.4592581264399 0 0 51.3415451046657 1 2027.5 5574 False False 0.219573039098105 0.00477770915407814 1.81014820057657 0 0 0.000176951454458875 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 6 13373 21307 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999718481677849 0.999387354605726 0.999896680954833 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.975 0 0 0.4592581264399 0 0 62.0817219898698 1 1642.5 4479 False False 0 0 0 0 0 0 0 0.265547496198808 0.00577686092206708 2.18912593855065 0 0 0.000275807277411719 0.999718481677849 0.999387354605726 0.999896680954833 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Arg294Gly Rv1129c_p.Arg294Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4255 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3412 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Arg294Ser Rv1129c_p.Arg294Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4339 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3484 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Arg300Cys Rv1129c_p.Arg300Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Arg300Ser Rv1129c_p.Arg300Ser 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4299 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3447 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Arg308Cys Rv1129c_p.Arg308Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4387 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3519 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Arg308His Rv1129c_p.Arg308His 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4311 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3460 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Arg309Gln Rv1129c_p.Arg309Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Arg309Trp Rv1129c_p.Arg309Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4388 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3522 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Arg330Gln Rv1129c_p.Arg330Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4274 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3429 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Arg330Leu Rv1129c_p.Arg330Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4217 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3380 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Arg358Trp Rv1129c_p.Arg358Trp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 7 0 20839 27468 0.000335795836131632 0.000135017659185429 0.000691744589626827 1 0.999865711673152 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 4332 5574 False False Inf 1.89951899263229 Inf 0 0 0.00017700239811062 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 5 0 13369 21313 0.000373859727830118 0.000121402023062639 0.000872246401868143 1 0.999826933785262 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 3478 4479 False False 0 0 0 0 0 0 0 Inf 1.46057233596553 Inf 0 0 0.000275889787465637 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Arg3fs Rv1129c_p.Arg3fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4275 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Arg3Gln Rv1129c_p.Arg3Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 7 20846 27461 0 0 0.00017694296670111 0.999745158002038 0.999474999027776 0.999897534357495 0 0 0.409616397225003 0 0 0.707598226178713 0 0 0.409616397225003 0 0 3.18818879865849 0.264059517086452 427.5 5574 False False 0 0 0.914121240039481 0 0 0.00017694296670111 0.999745158002038 0.999474999027776 0.999897534357495 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 5 13374 21308 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 3.85615642482772 0.289252196403212 283.5 4479 False False 0 0 0 0 0 0 0 0 0 1.73894646374006 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Arg452Gln Rv1129c_p.Arg452Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Arg466Cys Rv1129c_p.Arg466Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Asn166Asp Rv1129c_p.Asn166Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 28 12 20818 27456 0.00134318334452652 0.000892715366584833 0.00194069331308385 0.999563128003495 0.99923699702714 0.999774242139628 0.7 0.534683714745876 0.834372795606764 0 0 0.369416647552819 0 0 0.264648469397051 0 0 0.772734423311289 0.0121493372466101 133 5574 False False 3.0773369199731 1.51493855436115 6.64652673409465 0 0 0.000177180932121844 0.999563128003495 0.99923699702714 0.999774242139628 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 18 11 13356 21302 0.00134589502018842 0.000797851614369596 0.00212626349435784 0.999483883076056 0.999076712346733 0.999742329032819 0.620689655172413 0.422604640664401 0.793131300513492 0 0 0.409616397225003 0 0 0.284914152918154 0 0 1.10680729286472 0.0484820945694218 140 4479 False False 0 0 0 0 0 0 0 2.60989953442783 1.1668965897763 6.11681975982427 0 0 0.000276158286414525 0.999483883076056 0.999076712346733 0.999742329032819 4 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Asn166Ser Rv1129c_p.Asn166Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Asn211Asp Rv1129c_p.Asn211Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4256 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3413 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 4 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Asn211Ser Rv1129c_p.Asn211Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4389 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Asn279Asp Rv1129c_p.Asn279Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4340 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3485 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Asn411Asp Rv1129c_p.Asn411Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4247 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3405 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Asn411Tyr Rv1129c_p.Asn411Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 26 23 20820 27445 0.00124724167706034 0.000814896390023582 0.00182696777478964 0.999162662006698 0.998743845166008 0.999469127824854 0.530612244897959 0.382730734933759 0.674661274883446 0 0 0.975 0 0 0.148185128915224 0 0 51.3713511388536 1 2027.5 5574 False False 1.4901432569018 0.817065892625859 2.73442006664708 0 0 0.00017716391336717 0.999162662006698 0.998743845166008 0.999469127824854 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 20 21 13354 21292 0.00149543891132047 0.000913684725149316 0.00230864386780147 0.999014685872472 0.998494234949238 0.9993899748178 0.48780487804878 0.328779035771273 0.648657606182584 0 0 0.975 0 0 0.161097615219079 0 0 62.1262429846227 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.51850346249028 0.780659310264838 2.94491217897062 0 0 0.000276199640337768 0.999014685872472 0.998494234949238 0.9993899748178 3 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Asn451Lys Rv1129c_p.Asn451Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Asn5fs Rv1129c_p.Asn5fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 4 5 20842 27463 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999817970001456 0.999575254267103 0.999940892797913 0.444444444444444 0.136995662265166 0.787991493221131 0 0 0.841886116991581 0 0 0.521823750104981 0 0 7.01656881355278 0.509388361925866 1157 5574 False False 1.05414067747816 0.209146339999741 4.89812409436146 0 0 0.000176976922618654 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 2 13371 21311 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999906160559283 0.999661061221376 0.999988635406343 0.6 0.146632799634673 0.947255049473683 0 0 0.975 0 0 0.841886116991581 0 0 62.1026435994552 1 1642.5 4479 False False 0 0 0 0 0 0 0 2.39073367736145 0.273835790357664 28.6284716983702 0 0 0.000275848526268708 0.999906160559283 0.999661061221376 0.999988635406343 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Asn5Lys Rv1129c_p.Asn5Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4324 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3472 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Asn5Ser Rv1129c_p.Asn5Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 1.99597553667858 0.139114336996004 304.5 5574 False False 0 0 1.43785249906968 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Asp160Ala Rv1129c_p.Asp160Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 13 1 12 97 20 20749 27448 0.00465317087210975 0.00377497977748854 0.00567356718829501 0.999271880005825 0.998875700613314 0.999555190458412 0.829059829059829 0.748416976022331 0.892345613270113 0.0769230769230769 0.00194562849734675 0.360297435267877 0.0476190476190476 0.00120488344836351 0.238159909936821 0.110238244413385 0.00258295719836301 0.745222616702468 0.00987336233400447 119 5574 False False 6.41586582485902 3.93380836737719 10.9685382972731 4.81927710843373e-05 1.22013458017928e-06 0.000268483356964092 0.999271880005825 0.998875700613314 0.999555190458412 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 63 15 13311 21298 0.00471063257065948 0.00362162126806202 0.00602297592918337 0.999296204194623 0.998839461100611 0.999606039023746 0.807692307692307 0.702729430052343 0.888180315320899 0 0 0.336267116879942 0 0 0.218019360910534 0 0 0.810794011176956 0.0154952664529182 108 4479 False False 0 0 0 0 0 0 0 6.7201262114041 3.78064497769029 12.7136237637069 0 0 0.000277091755049731 0.999296204194623 0.998839461100611 0.999606039023746 10 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Asp160Asn Rv1129c_p.Asp160Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 8 3 20838 27465 0.000383766669864722 0.000165697303700768 0.000756032532322191 0.999890782000873 0.99968085216583 0.999977476056514 0.727272727272727 0.390257440427578 0.939782265827093 0 0 0.841886116991581 0 0 0.707598226178713 0 0 7.01842677476188 0.509406178150806 1206 5574 False False 3.51473269987522 0.843433138662064 20.5704549703367 0 0 0.000177010891571197 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 5 1 13369 21312 0.000373859727830118 0.000121402023062639 0.000872246401868143 0.999953080279641 0.999738608085756 0.999998812096234 0.833333333333333 0.358765421002325 0.99578925548551 0 0 0.975 0 0 0.975 0 0 62.114836709663 1 1642.5 4479 False False 0 0 0 0 0 0 0 7.97067843518587 0.891722638077622 376.304140424995 0 0 0.000275889787465637 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Asp160Glu Rv1129c_p.Asp160Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 4303 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3452 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Asp160Gly Rv1129c_p.Asp160Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 8 2 20838 27466 0.000383766669864722 0.000165697303700768 0.000756032532322191 0.999927188000582 0.999737003036386 0.999991182007438 0.8 0.443904537692358 0.974789273673166 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01868230221438 0.509408629602267 1207 5574 False False 5.27229100681447 1.05199089761157 50.9538747369096 0 0 0.000177010891571197 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 5 2 13369 21311 0.000373859727830118 0.000121402023062639 0.000872246401868143 0.999906160559283 0.999661061221376 0.999988635406343 0.714285714285714 0.290420863737342 0.963307433823914 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48852531192879 0.526218871049245 973 4479 False False 0 0 0 0 0 0 0 3.98515221781733 0.652287032938702 41.8973624237223 0 0 0.000275889787465637 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Asp164His Rv1129c_p.Asp164His 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4276 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Asp191Ala Rv1129c_p.Asp191Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4290 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Asp191Asn Rv1129c_p.Asp191Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Asp191Gly Rv1129c_p.Asp191Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 18 7 20828 27461 0.000863475007195625 0.000511827761943967 0.00136432078973001 0.999745158002038 0.999474999027776 0.999897534357495 0.72 0.506123178193744 0.879283311495933 0 0 0.4592581264399 0 0 0.409616397225003 0 0 1.11993550661866 0.0402651354843587 223 5574 False False 3.39033992702131 1.35081418594235 9.60250016337595 0 0 0.000177095871029953 0.999745158002038 0.999474999027776 0.999897534357495 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 16 6 13358 21307 0.00119635112905637 0.00068396778211822 0.00194207416051199 0.999718481677849 0.999387354605726 0.999896680954833 0.727272727272727 0.497778798733651 0.892710751629603 0 0 0.521823750104981 0 0 0.4592581264399 0 0 1.74094712228219 0.163962598025554 272 4479 False False 0 0 0 0 0 0 0 4.25353096770973 1.5804052101304 13.2752725014128 0 0 0.00027611694487284 0.999718481677849 0.999387354605726 0.999896680954833 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Asp200Ala Rv1129c_p.Asp200Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4380 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3514 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Asp200Asn Rv1129c_p.Asp200Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4257 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3414 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Asp200His Rv1129c_p.Asp200His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Asp209Ala Rv1129c_p.Asp209Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Asp209Gly Rv1129c_p.Asp209Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4248 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Asp214Asn Rv1129c_p.Asp214Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 2 20844 27466 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999927188000582 0.999737003036386 0.999991182007438 0.5 0.067585986488543 0.932414013511457 1 0.158113883008419 1 0.5 0.067585986488543 0.932414013511457 Inf 0.247453880220188 Inf 0.18617595452717 414.5 5574 False False 1.3176933410094 0.0955278435529395 18.1762534351792 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 2 13372 21311 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999906160559283 0.999661061221376 0.999988635406343 0.5 0.067585986488543 0.932414013511457 1 0.158113883008419 1 0.5 0.067585986488543 0.932414013511457 Inf 0.299279663612949 Inf 0.148668612101729 227 4479 False False 0 0 0 0 0 0 0 1.59370326054442 0.115491055908661 21.9865025501046 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999906160559283 0.999661061221376 0.999988635406343 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Asp223Glu Rv1129c_p.Asp223Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4258 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3415 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Asp223His Rv1129c_p.Asp223His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4259 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Asp262Gly Rv1129c_p.Asp262Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 4 2 20842 27466 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999927188000582 0.999737003036386 0.999991182007438 0.666666666666666 0.222778095503512 0.956728131707258 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4366 5574 False False 2.63563957393724 0.377684835565828 29.1411399702847 0 0 0.000176976922618654 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 2 13372 21311 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999906160559283 0.999661061221376 0.999988635406343 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3504 4479 False False 0 0 0 0 0 0 0 1.59370326054442 0.115491055908661 21.9865025501046 0 0 0.000275827900298067 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Asp302Asn Rv1129c_p.Asp302Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4379 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3513 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Asp387Glu Rv1129c_p.Asp387Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4325 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3473 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Asp387Gly Rv1129c_p.Asp387Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 3 1 20843 27467 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999963594000291 0.999797175631493 0.999999078280314 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 4374 5574 False False 3.95341361608213 0.31739219148065 207.323829234655 0 0 0.00017696843241753 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3508 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Asp419Asn Rv1129c_p.Asp419Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Asp41Asn Rv1129c_p.Asp41Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4342 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3487 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Asp81Ala Rv1129c_p.Asp81Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4218 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3381 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Asp87Glu Rv1129c_p.Asp87Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Gln105Arg Rv1129c_p.Gln105Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Gln105Glu Rv1129c_p.Gln105Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 11 2 20835 27466 0.000527679171063993 0.000263444034397523 0.000943967185544106 0.999927188000582 0.999737003036386 0.999991182007438 0.846153846153846 0.545528944323442 0.980793328017471 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01969293171451 0.50941832594669 1210 5574 False False 7.25044396448284 1.58206940172597 67.4160671725854 0 0 0.000177036376844338 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 62.1009148060541 1 1642.5 4479 False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 0 0 0.000275827900298067 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Gln105Pro Rv1129c_p.Gln105Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 4 1 20842 27467 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999963594000291 0.999797175631493 0.999999078280314 0.8 0.28358206388191 0.994949236620532 NA NA NA 0 0 0.975 NA NA NA NA 4307 5574 False False 5.27147106803569 0.521589398427432 259.279173455301 0 0 0.000176976922618654 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 3 1 13371 21312 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999953080279641 0.999738608085756 0.999998812096234 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 3455 4479 False False 0 0 0 0 0 0 0 4.78169172088849 0.383875689805931 250.696170545132 0 0 0.000275848526268708 0.999953080279641 0.999738608085756 0.999998812096234 2 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Gln237Pro Rv1129c_p.Gln237Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Gln329Pro Rv1129c_p.Gln329Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 7 5 20839 27463 0.000335795836131632 0.000135017659185429 0.000691744589626827 0.999817970001456 0.999575254267103 0.999940892797913 0.583333333333333 0.276669685682105 0.848347770191569 0 0 0.975 0 0 0.521823750104981 0 0 51.3581841046511 1 2027.5 5574 False False 1.84501175680214 0.503997297925076 7.37316142205045 0 0 0.00017700239811062 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 4 5 13370 21308 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 0.999765401398207 0.999452610763328 0.999923822225278 0.444444444444444 0.136995662265166 0.787991493221131 0 0 0.975 0 0 0.521823750104981 0 0 62.0985499200668 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.27497382198952 0.252954323547563 5.92545609271499 0 0 0.000275869155324334 0.999765401398207 0.999452610763328 0.999923822225278 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Gln384His Rv1129c_p.Gln384His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 51.3533466119536 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Gln74His Rv1129c_p.Gln74His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 4 20845 27464 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999854376001165 0.999627187086024 0.999960320981843 0.2 0.00505076337946806 0.716417936118089 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4308 5574 False False 0.329383545214679 0.00669260119676484 3.32889360843958 0 0 0.000176951454458875 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3456 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Glu107Asp Rv1129c_p.Glu107Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 10 2 20836 27466 0.000479708337330902 0.000230061997553563 0.000882023176671562 0.999927188000582 0.999737003036386 0.999991182007438 0.833333333333333 0.515862251314033 0.979137474539907 0 0 0.975 0 0 0.841886116991581 0 0 51.3711791602778 1 2027.5 5574 False False 6.59099635246688 1.40433109003891 61.9123962243262 0 0 0.000177027880937939 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 10 1 13364 21312 0.000747719455660236 0.000358616922835118 0.00137465137870696 0.999953080279641 0.999738608085756 0.999998812096234 0.909090909090909 0.587220083011617 0.997701027786185 NA NA NA 0 0 0.975 NA NA NA NA 3520 4479 False False 0 0 0 0 0 0 0 15.9473211613289 2.26794807805506 689.853896155571 0 0 0.000275992994481552 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Glu115Ala Rv1129c_p.Glu115Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4266 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3422 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Glu115Lys Rv1129c_p.Glu115Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4249 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3406 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Glu133Asp Rv1129c_p.Glu133Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 18 7 20828 27461 0.000863475007195625 0.000511827761943967 0.00136432078973001 0.999745158002038 0.999474999027776 0.999897534357495 0.72 0.506123178193744 0.879283311495933 0 0 0.602364635616474 0 0 0.409616397225003 0 0 1.99755299235529 0.139194718228595 363 5574 False False 3.39033992702131 1.35081418594235 9.60250016337595 0 0 0.000177095871029953 0.999745158002038 0.999474999027776 0.999897534357495 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 15 5 13359 21308 0.00112157918349035 0.000627870944551516 0.00184920065907577 0.999765401398207 0.999452610763328 0.999923822225278 0.75 0.508954128292042 0.913428530898565 0 0 0.707598226178713 0 0 0.521823750104981 0 0 3.86048708849219 0.289434893292179 416 4479 False False 0 0 0 0 0 0 0 4.78508870424432 1.65264627470632 16.8332157833454 0 0 0.000276096278743345 0.999765401398207 0.999452610763328 0.999923822225278 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Glu133Lys Rv1129c_p.Glu133Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 7 5 20839 27463 0.000335795836131632 0.000135017659185429 0.000691744589626827 0.999817970001456 0.999575254267103 0.999940892797913 0.583333333333333 0.276669685682105 0.848347770191569 0 0 0.707598226178713 0 0 0.521823750104981 0 0 3.18949208973596 0.264100745480466 569 5574 False False 1.84501175680214 0.503997297925076 7.37316142205045 0 0 0.00017700239811062 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 2 5 13372 21308 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999765401398207 0.999452610763328 0.999923822225278 0.285714285714285 0.0366925661760855 0.709579136262657 0 0 0.707598226178713 0 0 0.521823750104981 0 0 3.85673328502876 0.289276522367762 382 4479 False False 0 0 0 0 0 0 0 0.637391564463057 0.0606680462541562 3.89402937569226 0 0 0.000275827900298067 0.999765401398207 0.999452610763328 0.999923822225278 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Glu135Ala Rv1129c_p.Glu135Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 12 0 12 27 25 20819 27443 0.00129521251079343 0.000853721301750774 0.00188391092655412 0.999089850007281 0.998656730244862 0.999410915028568 0.519230769230769 0.376313489436986 0.659880848879433 0 0 0.264648469397051 0 0 0.137185171530712 0 0 0.474464612686541 0.0018396348248829 86 5574 False False 1.42362457370671 0.795076519725472 2.55826524754586 0 0 0.000177172422335812 0.999089850007281 0.998656730244862 0.999410915028568 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 13 20 13361 21293 0.000972035292358307 0.000517666151348512 0.00166163634851859 0.99906160559283 0.998551096167295 0.999426713067202 0.393939393939393 0.2290662383642 0.578606278611749 0 0 0.336267116879942 0 0 0.168433470983085 0 0 0.807570216378597 0.0153738984728353 103 4479 False False 0 0 0 0 0 0 0 1.03588429009804 0.473378239390435 2.1891269316962 0 0 0.000276054955763573 0.99906160559283 0.998551096167295 0.999426713067202 4 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Glu135Gln Rv1129c_p.Glu135Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18880616510555 0.264079043314886 541.5 5574 False False 0.439194051331254 0.00837049629364692 5.4704842261679 0 0 0.000176951454458875 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48598624162872 0.526186417038858 925 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Glu135Gly Rv1129c_p.Glu135Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 15 2 20831 27466 0.000719562505996354 0.000402787826414311 0.00118653165660568 0.999927188000582 0.999737003036386 0.999991182007438 0.88235294117647 0.635590837898749 0.985420683159697 0 0 0.975 0 0 0.841886116991581 0 0 51.3834997245633 1 1253.5 5574 False False 9.88886755316595 2.29908286227051 89.1762711751101 0 0 0.000177070368626196 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 3492 4479 False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 0 0 0.000275827900298067 0.999953080279641 0.999738608085756 0.999998812096234 3 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Glu135Lys Rv1129c_p.Glu135Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 13 3 20833 27465 0.000623620838530173 0.000332092285535748 0.00106617452923529 0.999890782000873 0.99968085216583 0.999977476056514 0.8125 0.543543453768388 0.959526266094054 0.333333333333333 0.00840375865961264 0.905700675949754 0.25 0.00630946320970987 0.805879550316756 0.659170546728747 0.0111778801852103 12.6635690527047 1 2027.5 5574 False False 5.71281140498248 1.56947663544128 31.2617662692511 4.79984640491504e-05 1.21521515796269e-06 0.00026740098547304 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 5 2 13369 21311 0.000373859727830118 0.000121402023062639 0.000872246401868143 0.999906160559283 0.999661061221376 0.999988635406343 0.714285714285714 0.290420863737342 0.963307433823914 0.5 0.012579117093425 0.987420882906574 0.333333333333333 0.00840375865961264 0.905700675949754 1.59406088712693 0.0203056784753281 125.015309774372 1 1642.5 4479 False False 0 0 0 0 0 0 0 3.98515221781733 0.652287032938702 41.8973624237223 7.47943156320119e-05 1.89362632857505e-06 0.000416656014965588 0.999906160559283 0.999661061221376 0.999988635406343 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Glu146Lys Rv1129c_p.Glu146Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Glu146Val Rv1129c_p.Glu146Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4211 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Glu156Gly Rv1129c_p.Glu156Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4326 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3474 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Glu157Gly Rv1129c_p.Glu157Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4375 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3509 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Glu268Lys Rv1129c_p.Glu268Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4277 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3430 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Glu291Gln Rv1129c_p.Glu291Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4312 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3461 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Glu297Gln Rv1129c_p.Glu297Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4327 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3475 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Glu297Val Rv1129c_p.Glu297Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4309 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3457 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Glu440Ala Rv1129c_p.Glu440Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4397 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3528 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 4 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Glu471Asp Rv1129c_p.Glu471Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4367 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Glu483Ala Rv1129c_p.Glu483Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 1.99597553667858 0.139114336996004 304.5 5574 False False 0 0 1.43785249906968 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 5 13374 21308 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 2.41409066157565 0.305475026346142 461 4479 False False 0 0 0 0 0 0 0 0 0 1.73894646374006 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Glu483Lys Rv1129c_p.Glu483Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 6 20846 27462 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 4390 5574 False False 0 0 1.11900921779861 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 13374 21307 0 0 0.000275786657608973 0.999718481677849 0.999387354605726 0.999896680954833 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 3523 4479 False False 0 0 0 0 0 0 0 0 0 1.35335561005417 0 0 0.000275786657608973 0.999718481677849 0.999387354605726 0.999896680954833 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Glu67Ala Rv1129c_p.Glu67Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4223 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3386 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Glu67Lys Rv1129c_p.Glu67Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4224 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3387 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Glu98Ala Rv1129c_p.Glu98Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 7.01547785354097 0.509377906736075 843 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Glu98Gly Rv1129c_p.Glu98Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 5 2 20841 27466 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.999927188000582 0.999737003036386 0.999991182007438 0.714285714285714 0.290420863737342 0.963307433823914 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4318 5574 False False 3.29470754762247 0.539313466840718 34.60579842565 0 0 0.000176985413634466 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3466 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Glu98Lys Rv1129c_p.Glu98Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 18 1 17 3 17 20843 27451 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999381098004951 0.999009262277189 0.999639426758727 0.15 0.0320709371854637 0.378926826545313 0.0555555555555555 0.00140555616736942 0.272943599673368 0.0555555555555555 0.00140555616736942 0.272943599673368 0.0774727585223985 0.00185798533160305 0.494538166414703 0.00114171032126451 78 5574 False False 0.232418275567195 0.0436362565216145 0.803729427737468 4.79754365764728e-05 1.21463215353938e-06 0.000267272712750976 0.999381098004951 0.999009262277189 0.999639426758727 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 16 1 15 3 15 13371 21298 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999296204194623 0.998839461100611 0.999606039023746 0.166666666666666 0.0357850831215746 0.414177491394774 0.0625 0.00158111172276588 0.302320738434531 0.0625 0.00158111172276588 0.302320738434531 0.106190013212674 0.00252644961581861 0.690398598709623 0.00796264646148382 69 4479 False False 0 0 0 0 0 0 0 0.318570039638022 0.0591108516761482 1.12648849438386 7.47831289261142e-05 1.89334310623943e-06 0.000416593707936992 0.999296204194623 0.998839461100611 0.999606039023746 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Gly103Ala Rv1129c_p.Gly103Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4291 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3439 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Gly103Asp Rv1129c_p.Gly103Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Gly117Ala Rv1129c_p.Gly117Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4235 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Gly184Ala Rv1129c_p.Gly184Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0337875782094303 Inf 0.431457371721896 645 5574 False False Inf 0.247471899512553 Inf 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.040864745349235 Inf 0.385544600126852 512 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 7.47775368279368e-05 1.89320152683959e-06 0.000416562561410248 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Gly188Arg Rv1129c_p.Gly188Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 10 20844 27458 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999635940002912 0.999330582956894 0.999825405716755 0.166666666666666 0.0208625254600923 0.484137748685967 NA NA NA 0 0 0.30849710781876 NA NA NA NA 4225 5574 False False 0.263461907503358 0.0280628850635093 1.23651586577642 0 0 0.000176959943030976 0.999635940002912 0.999330582956894 0.999825405716755 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 9 13372 21304 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999577722516773 0.999198537836033 0.999806890245066 0.181818181818181 0.0228311982999596 0.517755852360172 NA NA NA 0 0 0.336267116879942 NA NA NA NA 3388 4479 False False 0 0 0 0 0 0 0 0.354039950809319 0.0372201067241714 1.71091270173505 0 0 0.000275827900298067 0.999577722516773 0.999198537836033 0.999806890245066 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Gly188Ser Rv1129c_p.Gly188Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.18853708762714 0.264070532102877 442 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.85633740727807 0.289259828934126 294 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Gly19Ala Rv1129c_p.Gly19Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4304 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3453 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Gly236Glu Rv1129c_p.Gly236Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4381 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3515 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Gly250Arg Rv1129c_p.Gly250Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Gly271Ser Rv1129c_p.Gly271Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 4 20845 27464 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999854376001165 0.999627187086024 0.999960320981843 0.2 0.00505076337946806 0.716417936118089 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4350 5574 False False 0.329383545214679 0.00669260119676484 3.32889360843958 0 0 0.000176951454458875 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3493 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Gly271Val Rv1129c_p.Gly271Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Gly311Glu Rv1129c_p.Gly311Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 4 8 20842 27460 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.99970875200233 0.999426206431739 0.999874251669172 0.333333333333333 0.0992460911495833 0.651124493581186 0 0 0.602364635616474 0 0 0.369416647552819 0 0 1.99614033887509 0.139122726023332 339 5574 False False 0.6587659533634 0.145144754371229 2.45951022691276 0 0 0.000176976922618654 0.99970875200233 0.999426206431739 0.999874251669172 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 5 13373 21308 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999765401398207 0.999452610763328 0.999923822225278 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.841886116991581 0 0 0.521823750104981 0 0 8.48479173529998 0.526171149875135 678 4479 False False 0 0 0 0 0 0 0 0.318671950945935 0.00674139558547252 2.84834809554519 0 0 0.000275807277411719 0.999765401398207 0.999452610763328 0.999923822225278 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Gly311Val Rv1129c_p.Gly311Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4398 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3529 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Gly360Asp Rv1129c_p.Gly360Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 4 1 20842 27467 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999963594000291 0.999797175631493 0.999999078280314 0.8 0.28358206388191 0.994949236620532 0 0 0.975 0 0 0.975 0 0 51.3582705287504 1 2027.5 5574 False False 5.27147106803569 0.521589398427432 259.279173455301 0 0 0.000176976922618654 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 1 13371 21312 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999953080279641 0.999738608085756 0.999998812096234 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 62.1055547471297 1 1642.5 4479 False False 0 0 0 0 0 0 0 4.78169172088849 0.383875689805931 250.696170545132 0 0 0.000275848526268708 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Gly360Cys Rv1129c_p.Gly360Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4250 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Gly360Ser Rv1129c_p.Gly360Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4368 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3505 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Gly360Val Rv1129c_p.Gly360Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 4 20845 27464 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999854376001165 0.999627187086024 0.999960320981843 0.2 0.00505076337946806 0.716417936118089 0 0 0.975 0 0 0.602364635616474 0 0 51.3452810661646 1 2027.5 5574 False False 0.329383545214679 0.00669260119676484 3.32889360843958 0 0 0.000176951454458875 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Gly361Ala Rv1129c_p.Gly361Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4333 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3479 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Gly361Asp Rv1129c_p.Gly361Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4292 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3440 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Gly361Cys Rv1129c_p.Gly361Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 4 2 20842 27466 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999927188000582 0.999737003036386 0.999991182007438 0.666666666666666 0.222778095503512 0.956728131707258 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4313 5574 False False 2.63563957393724 0.377684835565828 29.1411399702847 0 0 0.000176976922618654 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3462 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Gly361Ser Rv1129c_p.Gly361Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 51.3533466119536 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3448 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Gly361Val Rv1129c_p.Gly361Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4278 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3431 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Gly402Ala Rv1129c_p.Gly402Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Gly402Arg Rv1129c_p.Gly402Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4351 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Gly402Glu Rv1129c_p.Gly402Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 14 1 13 20 19 20826 27449 0.000959416674661805 0.000586132014909014 0.00148135424594851 0.999308286005533 0.998920012739518 0.999583493240977 0.512820512820512 0.34780220935734 0.675819219034392 0.0714285714285714 0.00180678065912538 0.338684489931821 0.05 0.0012650894979498 0.248732762772027 0.101385841662419 0.00238983872043141 0.675126800917959 0.00566341624437512 108 5574 False False 1.38738520169626 0.702662751774736 2.74842318888695 4.80145964373169e-05 1.2156235941722e-06 0.000267490849662101 0.999308286005533 0.998920012739518 0.999583493240977 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 1 10 19 15 13355 21298 0.00142066696575444 0.000855544226513897 0.00221766232087821 0.999296204194623 0.998839461100611 0.999606039023746 0.558823529411764 0.378857643957071 0.728149803585133 0.0909090909090909 0.00229897221381426 0.412779916988382 0.0625 0.00158111172276588 0.302320738434531 0.159475851740921 0.00367862384292926 1.12125285797025 0.0603608885575664 146 4479 False False 0 0 0 0 0 0 0 2.02002745538499 0.972306121900744 4.27305581143644 7.48727163821503e-05 1.89561125995218e-06 0.000417092686567141 0.999296204194623 0.998839461100611 0.999606039023746 2 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Gly402Trp Rv1129c_p.Gly402Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Gly404Ala Rv1129c_p.Gly404Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Gly407Asp Rv1129c_p.Gly407Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 2 2 20844 27466 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999927188000582 0.999737003036386 0.999991182007438 0.5 0.067585986488543 0.932414013511457 0.5 0.012579117093425 0.987420882906574 0.333333333333333 0.00840375865961264 0.905700675949754 1.3176933410094 0.0167929463371296 103.358311851004 1 2027.5 5574 False False 1.3176933410094 0.0955278435529395 18.1762534351792 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.59377804367334 0.0203020758039404 124.993150249237 1 1642.5 4479 False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 7.47775368279368e-05 1.89320152683959e-06 0.000416562561410248 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Gly407Ser Rv1129c_p.Gly407Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01632529799099 0.509386028876591 1135.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Gly415Val Rv1129c_p.Gly415Val 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4391 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3524 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Gly431Arg Rv1129c_p.Gly431Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4236 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3395 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Gly446Ala Rv1129c_p.Gly446Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4314 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3463 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Gly446Cys Rv1129c_p.Gly446Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4267 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3423 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Gly446Ser Rv1129c_p.Gly446Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4315 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Gly446Val Rv1129c_p.Gly446Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 4 1 20842 27467 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999963594000291 0.999797175631493 0.999999078280314 0.8 0.28358206388191 0.994949236620532 0 0 0.975 0 0 0.975 0 0 51.3582705287504 1 2027.5 5574 False False 5.27147106803569 0.521589398427432 259.279173455301 0 0 0.000176976922618654 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 1 13371 21312 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999953080279641 0.999738608085756 0.999998812096234 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 62.1055547471297 1 1642.5 4479 False False 0 0 0 0 0 0 0 4.78169172088849 0.383875689805931 250.696170545132 0 0 0.000275848526268708 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Gly474Asp Rv1129c_p.Gly474Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3424 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Gly474Ser Rv1129c_p.Gly474Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Gly474Val Rv1129c_p.Gly474Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Gly96Arg Rv1129c_p.Gly96Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4237 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3396 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.His118Pro Rv1129c_p.His118Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4243 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3402 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.His118Tyr Rv1129c_p.His118Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.658815063564403 0.011171855707321 12.6567401482543 1 2027.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.His221Gln Rv1129c_p.His221Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.His231Pro Rv1129c_p.His231Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4343 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.His293Asn Rv1129c_p.His293Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4392 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.His355Arg Rv1129c_p.His355Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01632529799099 0.509386028876591 1135.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48598624162872 0.526186417038858 925 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.His355Gln Rv1129c_p.His355Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.His409Arg Rv1129c_p.His409Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ile106Val Rv1129c_p.Ile106Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4226 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ile208Val Rv1129c_p.Ile208Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4219 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3382 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ile242Val Rv1129c_p.Ile242Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 51.3446878573018 1 2027.5 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 62.0858160113928 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ile303Leu Rv1129c_p.Ile303Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4260 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3416 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ile303Thr Rv1129c_p.Ile303Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 4285 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3436 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ile332Leu Rv1129c_p.Ile332Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 0 0 0.975 0 0 0.707598226178713 0 0 51.3471490467504 1 2027.5 5574 False False 0.439194051331254 0.00837049629364692 5.4704842261679 0 0 0.000176951454458875 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 3 13373 21310 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999859240838924 0.999588697652472 0.999970971136275 0.25 0.00630946320970987 0.805879550316756 0 0 0.975 0 0 0.707598226178713 0 0 62.0904541316821 1 1642.5 4479 False False 0 0 0 0 0 0 0 0.531169769934445 0.010122018243966 6.61631049307563 0 0 0.000275807277411719 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ile332Met Rv1129c_p.Ile332Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4358 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3499 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ile332Thr Rv1129c_p.Ile332Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4279 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3432 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ile345Met Rv1129c_p.Ile345Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ile378Met Rv1129c_p.Ile378Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4305 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ile443Ala Rv1129c_p.Ile443Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4344 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ile443Met Rv1129c_p.Ile443Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4393 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3525 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ile443Thr Rv1129c_p.Ile443Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 10 0 20836 27468 0.000479708337330902 0.000230061997553563 0.000882023176671562 1 0.999865711673152 1 1 0.691502892181239 1 NA NA NA NA NA NA NA NA NA NA 4394 5574 False False Inf 2.95450432812812 Inf 0 0 0.000177027880937939 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3526 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ile443Val Rv1129c_p.Ile443Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18880616510555 0.264079043314886 541.5 5574 False False 0.439194051331254 0.00837049629364692 5.4704842261679 0 0 0.000176951454458875 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 3 13373 21310 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999859240838924 0.999588697652472 0.999970971136275 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85680682534852 0.289279625558287 389.5 4479 False False 0 0 0 0 0 0 0 0.531169769934445 0.010122018243966 6.61631049307563 0 0 0.000275807277411719 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ile449Val Rv1129c_p.Ile449Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 2 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ile95Thr Rv1129c_p.Ile95Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 51.3446878573018 1 2027.5 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3494 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ile95Val Rv1129c_p.Ile95Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4359 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3500 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Leu127Val Rv1129c_p.Leu127Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Leu134Pro Rv1129c_p.Leu134Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 4 3 20842 27465 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999890782000873 0.99968085216583 0.999977476056514 0.571428571428571 0.184051567640083 0.901011721557492 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18926519666227 0.264093566162961 563 5574 False False 1.75702907590442 0.297192930207644 11.9979296337129 0 0 0.000176976922618654 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Leu172Met Rv1129c_p.Leu172Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Leu172Val Rv1129c_p.Leu172Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Leu190Ser Rv1129c_p.Leu190Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Leu212Arg Rv1129c_p.Leu212Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 15 4 20831 27464 0.000719562505996354 0.000402787826414311 0.00118653165660568 0.999854376001165 0.999627187086024 0.999960320981843 0.789473684210526 0.544346918108494 0.93947546229071 0 0 0.841886116991581 0 0 0.602364635616474 0 0 7.02052966389243 0.509426355695186 1211 5574 False False 4.94407373625846 1.57469812694187 20.4593815730792 0 0 0.000177070368626196 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 10 4 13364 21309 0.000747719455660236 0.000358616922835118 0.00137465137870696 0.999812321118566 0.999519537882235 0.999948861529775 0.714285714285714 0.418964742816338 0.916110681692872 0 0 0.841886116991581 0 0 0.602364635616474 0 0 8.49090441341921 0.526249286432212 980 4479 False False 0 0 0 0 0 0 0 3.98626908111343 1.14940921033945 17.4090409327703 0 0 0.000275992994481552 0.999812321118566 0.999519537882235 0.999948861529775 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Leu212Gln Rv1129c_p.Leu212Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4403 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Leu212Pro Rv1129c_p.Leu212Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 7 1 20839 27467 0.000335795836131632 0.000135017659185429 0.000691744589626827 0.999963594000291 0.999797175631493 0.999999078280314 0.875 0.473490329124793 0.996840276468748 0 0 0.975 0 0 0.975 0 0 51.3656581746512 1 2027.5 5574 False False 9.22640241854215 1.18513781610454 415.029346412368 0 0 0.00017700239811062 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 6 1 13368 21312 0.000448631673396141 0.000164657143425453 0.000976224581517196 0.999953080279641 0.999738608085756 0.999998812096234 0.857142857142857 0.421276802956804 0.996389703138099 0 0 0.975 0 0 0.975 0 0 62.1194787314315 1 1642.5 4479 False False 0 0 0 0 0 0 0 9.56552962298025 1.16026312817987 439.068355223953 0 0 0.00027591042269331 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Leu227Phe Rv1129c_p.Leu227Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Leu233Gln Rv1129c_p.Leu233Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4352 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3495 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Leu265Phe Rv1129c_p.Leu265Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4212 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3375 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Leu299Ser Rv1129c_p.Leu299Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4328 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Leu305Pro Rv1129c_p.Leu305Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4334 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3480 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Leu306Met Rv1129c_p.Leu306Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4280 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3433 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Leu321Phe Rv1129c_p.Leu321Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 5 0 20841 27468 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 1 0.999865711673152 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 4369 5574 False False Inf 1.20760984683633 Inf 0 0 0.000176985413634466 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 5 0 13369 21313 0.000373859727830118 0.000121402023062639 0.000872246401868143 1 0.999826933785262 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 3506 4479 False False 0 0 0 0 0 0 0 Inf 1.46057233596553 Inf 0 0 0.000275889787465637 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Leu420Arg Rv1129c_p.Leu420Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Leu426Ile Rv1129c_p.Leu426Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4353 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Leu426Val Rv1129c_p.Leu426Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Leu477Met Rv1129c_p.Leu477Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4354 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3496 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Leu477Phe Rv1129c_p.Leu477Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4335 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Leu64Met Rv1129c_p.Leu64Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Lys217Asn Rv1129c_p.Lys217Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4316 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3464 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Lys225Asn Rv1129c_p.Lys225Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4206 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3371 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Lys341Asn Rv1129c_p.Lys341Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4360 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Lys425Arg Rv1129c_p.Lys425Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Lys425Thr Rv1129c_p.Lys425Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4251 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3407 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Lys448Thr Rv1129c_p.Lys448Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4336 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3481 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Met1? Rv1129c_p.Met1? 2 start_lost (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4370 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3507 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Met113Ile Rv1129c_p.Met113Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.18853708762714 0.264070532102877 442 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.85633740727807 0.289259828934126 294 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Met113Thr Rv1129c_p.Met113Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3408 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Met153Ile Rv1129c_p.Met153Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 2 20844 27466 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999927188000582 0.999737003036386 0.999991182007438 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4286 5574 False False 1.3176933410094 0.0955278435529395 18.1762534351792 0 0 0.000176959943030976 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Met153Thr Rv1129c_p.Met153Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4361 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3501 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Met174Ile Rv1129c_p.Met174Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Met174Val Rv1129c_p.Met174Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 51.349017027227 1 2027.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Met179Ile Rv1129c_p.Met179Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 51.3428199661809 1 2027.5 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Met234Ile Rv1129c_p.Met234Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Phe109Leu Rv1129c_p.Phe109Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Phe180Leu Rv1129c_p.Phe180Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4252 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3409 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Phe202Tyr Rv1129c_p.Phe202Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 78 0 20768 27468 0.00374172503118104 0.00295876822164733 0.00466767380859357 1 0.999865711673152 1 1 0.953807579671951 1 NA NA NA NA NA NA NA NA NA NA 4287 5574 False False Inf 27.2896486506239 Inf 0 0 0.000177607466205201 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 16 0 13358 21313 0.00119635112905637 0.00068396778211822 0.00194207416051199 1 0.999826933785262 1 1 0.794092785792177 1 NA NA NA NA NA NA NA NA NA NA 3437 4479 False False 0 0 0 0 0 0 0 Inf 6.15056952060403 Inf 0 0 0.00027611694487284 1 0.999826933785262 1 32 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Phe334Leu Rv1129c_p.Phe334Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 17 1 20829 27467 0.000815504173462534 0.000475130725961031 0.00130538114673077 0.999963594000291 0.999797175631493 0.999999078280314 0.944444444444444 0.727056400326631 0.99859444383263 0 0 0.975 0 0 0.975 0 0 51.3902990181465 1 2027.5 5574 False False 22.4177348888568 3.51196841137808 932.886543685562 0 0 0.000177087369412526 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 13 1 13361 21312 0.000972035292358307 0.000517666151348512 0.00166163634851859 0.999953080279641 0.999738608085756 0.999998812096234 0.928571428571428 0.661315510068178 0.998193219340874 0 0 0.975 0 0 0.975 0 0 62.1519923210371 1 1642.5 4479 False False 0 0 0 0 0 0 0 20.7361724421824 3.11360222105818 877.644616566529 0 0 0.000276054955763573 0.999953080279641 0.999738608085756 0.999998812096234 12 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Phe412Leu Rv1129c_p.Phe412Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4227 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3389 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Phe460Leu Rv1129c_p.Phe460Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4281 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3434 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Phe460Val Rv1129c_p.Phe460Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4399 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3530 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Pro149Leu Rv1129c_p.Pro149Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Pro149Ser Rv1129c_p.Pro149Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4261 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3417 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Pro327Leu Rv1129c_p.Pro327Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4228 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3390 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Pro333Arg Rv1129c_p.Pro333Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4207 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3372 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Pro333Ser Rv1129c_p.Pro333Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Pro386Ser Rv1129c_p.Pro386Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4300 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3449 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Pro408Leu Rv1129c_p.Pro408Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Pro408Ser Rv1129c_p.Pro408Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Pro437Leu Rv1129c_p.Pro437Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Pro442Arg Rv1129c_p.Pro442Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Pro461Arg Rv1129c_p.Pro461Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4371 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Pro461Leu Rv1129c_p.Pro461Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4288 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Pro461Ser Rv1129c_p.Pro461Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4268 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3425 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Pro461Thr Rv1129c_p.Pro461Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4253 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3410 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Pro478Ser Rv1129c_p.Pro478Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Pro8fs Rv1129c_p.Pro8fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Pro8Ser Rv1129c_p.Pro8Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ser119Arg Rv1129c_p.Ser119Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4341 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3486 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ser119Asn Rv1129c_p.Ser119Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4345 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3488 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ser119Gly Rv1129c_p.Ser119Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4208 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3373 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ser14Leu Rv1129c_p.Ser14Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ser183Cys Rv1129c_p.Ser183Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ser252Pro Rv1129c_p.Ser252Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4382 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ser266Asn Rv1129c_p.Ser266Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4238 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3397 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ser266Thr Rv1129c_p.Ser266Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 4 20845 27464 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999854376001165 0.999627187086024 0.999960320981843 0.2 0.00505076337946806 0.716417936118089 0 0 0.841886116991581 0 0 0.602364635616474 0 0 7.01581441470222 0.509381131851925 880 5574 False False 0.329383545214679 0.00669260119676484 3.32889360843958 0 0 0.000176951454458875 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 4 13373 21309 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999812321118566 0.999519537882235 0.999948861529775 0.2 0.00505076337946806 0.716417936118089 0 0 0.841886116991581 0 0 0.602364635616474 0 0 8.48518990407669 0.526176238728858 704.5 4479 False False 0 0 0 0 0 0 0 0.398358633066626 0.00809276091420046 4.02622197901862 0 0 0.000275807277411719 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ser346Leu Rv1129c_p.Ser346Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4319 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3467 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ser357Arg Rv1129c_p.Ser357Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4355 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3497 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ser357Asn Rv1129c_p.Ser357Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4262 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3418 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ser357Gly Rv1129c_p.Ser357Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4263 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3419 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ser362Thr Rv1129c_p.Ser362Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ser429Ala Rv1129c_p.Ser429Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ser438Thr Rv1129c_p.Ser438Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4293 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3441 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ser454Ala Rv1129c_p.Ser454Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4269 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ser475Arg Rv1129c_p.Ser475Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01632529799099 0.509386028876591 1135.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ser475Asn Rv1129c_p.Ser475Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.43785249906968 0.0743380732312645 251 5574 False False 0 0 1.43785249906968 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 13374 21308 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.73894646374006 0.163960020972012 248.5 4479 False False 0 0 0 0 0 0 0 0 0 1.73894646374006 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ser475Gly Rv1129c_p.Ser475Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4317 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3465 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ser476Asn Rv1129c_p.Ser476Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 7.01547785354097 0.509377906736075 843 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3516 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ser476Gly Rv1129c_p.Ser476Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4320 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3468 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ser480Pro Rv1129c_p.Ser480Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 22 1 21 6 27 20840 27441 0.000287825002398541 0.000105633792978048 0.000626367784710498 0.999017038007863 0.998570161716172 0.99935212504807 0.181818181818181 0.06978788366631 0.354600559450268 0.0454545454545454 0.00115014752657357 0.228444397667633 0.0357142857142857 0.000903798755658059 0.183477597544623 0.0627022210035645 0.00152045420572727 0.389943947798785 0.00010767264798905 61 5574 True False 0.292610364683301 0.0987667172510316 0.723622021166059 4.79823424979607e-05 1.21480699612118e-06 0.000267311181643879 0.999017038007863 0.998570161716172 0.99935212504807 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 15 1 14 4 17 13370 21296 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 0.999202364753906 0.998723214865585 0.999535281595187 0.19047619047619 0.0544635681784068 0.419066041183528 0.0666666666666666 0.0016864302413527 0.319484566578303 0.0555555555555555 0.00140555616736942 0.272943599673368 0.113772838978523 0.00269468376911909 0.74799570340129 0.0137399333737986 98 4479 False False 0 0 0 0 0 0 0 0.374781116635135 0.0917096311307887 1.14936729707937 7.47887218607434e-05 1.89348470681633e-06 0.000416624859121756 0.999202364753906 0.998723214865585 0.999535281595187 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ser4Arg Rv1129c_p.Ser4Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4229 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3391 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ser4Gly Rv1129c_p.Ser4Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ser77Tyr Rv1129c_p.Ser77Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 7 20846 27461 0 0 0.00017694296670111 0.999745158002038 0.999474999027776 0.999897534357495 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.914121240039481 0.0219749245408003 156 5574 False False 0 0 0.914121240039481 0 0 0.00017694296670111 0.999745158002038 0.999474999027776 0.999897534357495 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 7 13374 21306 0 0 0.000275786657608973 0.99967156195749 0.999323409938814 0.999867941002665 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 1.10552510564584 0.0484388314759391 130.5 4479 False False 0 0 0 0 0 0 0 0 0 1.10552510564584 0 0 0.000275786657608973 0.99967156195749 0.999323409938814 0.999867941002665 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ser78Leu Rv1129c_p.Ser78Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4213 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3376 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Ser89Ala Rv1129c_p.Ser89Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Thr12Met Rv1129c_p.Thr12Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 1 7 13 13 20833 27455 0.000623620838530173 0.000332092285535748 0.00106617452923529 0.999526722003786 0.99919081619501 0.999747976101462 0.5 0.299272179441596 0.700727820558403 0.125 0.0031597235312519 0.526509670875206 0.0714285714285714 0.00180678065912538 0.338684489931821 0.188265869396767 0.00418139250952556 1.46565681709998 0.14940842590684 370 5574 False False 1.31786108577737 0.562704377686945 3.08615194278479 4.79984640491504e-05 1.21521515796269e-06 0.00026740098547304 0.999526722003786 0.99919081619501 0.999747976101462 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 1 7 13 12 13361 21301 0.000972035292358307 0.000517666151348512 0.00166163634851859 0.999436963355698 0.999016695060306 0.999709037985722 0.52 0.313057044457032 0.722031990330053 0.125 0.0031597235312519 0.526509670875206 0.0769230769230769 0.00194562849734675 0.360297435267877 0.227752413741486 0.00505720785386148 1.77310230342069 0.163792837636007 231 4479 False False 0 0 0 0 0 0 0 1.72712247087293 0.726291762653362 4.14244851618966 7.4839095943721e-05 1.89476006576085e-06 0.000416905429568131 0.999436963355698 0.999016695060306 0.999709037985722 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Thr131Ala Rv1129c_p.Thr131Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 5 1 20841 27467 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.999963594000291 0.999797175631493 0.999999078280314 0.833333333333333 0.358765421002325 0.99578925548551 0 0 0.975 0 0 0.975 0 0 51.360732841256 1 2027.5 5574 False False 6.58965500695744 0.737267067818355 311.215258952954 0 0 0.000176985413634466 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3403 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Thr131Ile Rv1129c_p.Thr131Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Thr131Pro Rv1129c_p.Thr131Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 55 8 20791 27460 0.00263839585531996 0.00198820044990488 0.00343286781161324 0.99970875200233 0.999426206431739 0.999874251669172 0.873015873015873 0.765034424304345 0.943548720454697 0 0 0.707598226178713 0 0 0.369416647552819 0 0 3.19650698757787 0.264323352408212 577 5574 False False 9.08025107017459 4.29938991349925 22.0796506133195 0 0 0.000177411005749147 0.99970875200233 0.999426206431739 0.999874251669172 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 37 5 13337 21308 0.00276656198594287 0.00194864015550479 0.00381134478706768 0.999765401398207 0.999452610763328 0.999923822225278 0.88095238095238 0.743683322393622 0.960194471057311 0 0 0.841886116991581 0 0 0.521823750104981 0 0 8.50769497359174 0.526464154689046 985 4479 False False 0 0 0 0 0 0 0 11.8226887605908 4.63352044185655 38.5450853307001 0 0 0.000276551649377767 0.999765401398207 0.999452610763328 0.999923822225278 4 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Thr142Asn Rv1129c_p.Thr142Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4346 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3489 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Thr145Ile Rv1129c_p.Thr145Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Thr16Lys Rv1129c_p.Thr16Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 8 20846 27460 0 0 0.00017694296670111 0.99970875200233 0.999426206431739 0.999874251669172 0 0 0.369416647552819 0 0 0.521823750104981 0 0 0.369416647552819 0 0 1.43769496985327 0.0743287213697913 227.5 5574 False False 0 0 0.771808536885009 0 0 0.00017694296670111 0.99970875200233 0.999426206431739 0.999874251669172 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 8 13374 21305 0 0 0.000275786657608973 0.999624642237132 0.999260530264256 0.999837933676441 0 0 0.369416647552819 0 0 0.521823750104981 0 0 0.369416647552819 0 0 1.738701740061 0.163959746785355 233 4479 False False 0 0 0 0 0 0 0 0 0 0.93343997011793 0 0 0.000275786657608973 0.999624642237132 0.999260530264256 0.999837933676441 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Thr187Asn Rv1129c_p.Thr187Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Thr187Ile Rv1129c_p.Thr187Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4347 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3490 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Thr215Ala Rv1129c_p.Thr215Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 51.3533466119536 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3442 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Thr224Ser Rv1129c_p.Thr224Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.43785249906968 0.0743380732312645 251 5574 False False 0 0 1.43785249906968 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 13374 21308 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.73894646374006 0.163960020972012 248.5 4479 False False 0 0 0 0 0 0 0 0 0 1.73894646374006 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Thr261Pro Rv1129c_p.Thr261Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 12 12 20834 27456 0.000575650004797083 0.000297481006307132 0.00100532857413147 0.999563128003495 0.99923699702714 0.999774242139628 0.5 0.291241779836211 0.708758220163788 0 0 0.707598226178713 0 0 0.264648469397051 0 0 3.18944445830892 0.264099234471328 568 5574 False False 1.31784582893347 0.541422817893367 3.20786520421282 0 0 0.000177044873566246 0.999563128003495 0.99923699702714 0.999774242139628 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 12 12 13362 21301 0.000897263346792283 0.000463712283458933 0.00156681338714949 0.999436963355698 0.999016695060306 0.999709037985722 0.5 0.291241779836211 0.708758220163788 0 0 0.707598226178713 0 0 0.264648469397051 0 0 3.85835216184498 0.28934479975229 411 4479 False False 0 0 0 0 0 0 0 1.5941475826972 0.654843264228968 3.88071888513777 0 0 0.000276034298911909 0.999436963355698 0.999016695060306 0.999709037985722 2 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Thr267Ala Rv1129c_p.Thr267Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4214 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3377 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Thr2Ala Rv1129c_p.Thr2Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 1 6 20845 27462 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999781564001747 0.999524617886493 0.999919833755107 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.602364635616474 0 0 0.4592581264399 0 0 1.99599858618782 0.139115509937566 310.5 5574 False False 0.219573039098105 0.00477770915407814 1.81014820057657 0 0 0.000176951454458875 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 1 6 13373 21307 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999718481677849 0.999387354605726 0.999896680954833 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.602364635616474 0 0 0.4592581264399 0 0 2.41415795705756 0.305473914118518 456.5 4479 False False 0 0 0 0 0 0 0 0.265547496198808 0.00577686092206708 2.18912593855065 0 0 0.000275807277411719 0.999718481677849 0.999387354605726 0.999896680954833 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Thr2Met Rv1129c_p.Thr2Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 2 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Thr323Ala Rv1129c_p.Thr323Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 20 4 20826 27464 0.000959416674661805 0.000586132014909014 0.00148135424594851 0.999854376001165 0.999627187086024 0.999960320981843 0.833333333333333 0.626158286511317 0.952646373392742 0 0 0.841886116991581 0 0 0.602364635616474 0 0 7.02221521783251 0.509442539763785 1214 5574 False False 6.59368097570344 2.20820713211177 26.5326437556034 0 0 0.000177112876713918 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 7 3 13367 21310 0.000523403618962165 0.000210460468745924 0.00107811225334149 0.999859240838924 0.999588697652472 0.999970971136275 0.7 0.347547149940002 0.933260488822265 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.48939706943999 0.52623001493827 977.5 4479 False False 0 0 0 0 0 0 0 3.71985736016558 0.848991347451885 22.2950894269216 0 0 0.000275931061008045 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Thr430Pro Rv1129c_p.Thr430Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 4 2 20842 27466 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999927188000582 0.999737003036386 0.999991182007438 0.666666666666666 0.222778095503512 0.956728131707258 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01733524879011 0.509395710775307 1192 5574 False False 2.63563957393724 0.377684835565828 29.1411399702847 0 0 0.000176976922618654 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48598624162872 0.526186417038858 925 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Thr439Ala Rv1129c_p.Thr439Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4321 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3469 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Thr44Ala Rv1129c_p.Thr44Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4230 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Thr44Ile Rv1129c_p.Thr44Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4400 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Thr453Met Rv1129c_p.Thr453Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4209 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Trp232Arg Rv1129c_p.Trp232Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4372 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Trp232Gly Rv1129c_p.Trp232Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 19 0 19 5 28 20841 27440 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.998980632008154 0.998527063823414 0.999322533833553 0.151515151515151 0.0510886993560812 0.318989819710436 0 0 0.176466911806965 0 0 0.123436118500263 0 0 0.28217877073994 2.4827903827408e-05 49 5574 True False 0.235113478240007 0.0708744294331207 0.616901049899945 0 0 0.000176985413634466 0.998980632008154 0.998527063823414 0.999322533833553 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 2 17 13372 21296 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999202364753906 0.998723214865585 0.999535281595187 0.105263157894736 0.0130121643717774 0.331376664456765 0 0 0.30849710781876 0 0 0.195064322969093 0 0 0.71063855276041 0.00888714113720991 74 4479 False False 0 0 0 0 0 0 0 0.187362531013003 0.0209952676862771 0.789533094696692 0 0 0.000275827900298067 0.999202364753906 0.998723214865585 0.999535281595187 4 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Trp366Cys Rv1129c_p.Trp366Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4329 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Trp366Gly Rv1129c_p.Trp366Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4294 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Tyr137Asn Rv1129c_p.Tyr137Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4220 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3383 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Tyr137Asp Rv1129c_p.Tyr137Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 7 6 20839 27462 0.000335795836131632 0.000135017659185429 0.000691744589626827 0.999781564001747 0.999524617886493 0.999919833755107 0.538461538461538 0.251345482270303 0.807767558198712 0 0 0.841886116991581 0 0 0.4592581264399 0 0 7.01732342961303 0.509395595980606 1188 5574 False False 1.53745381256298 0.442344590021336 5.538005054617 0 0 0.00017700239811062 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 4 5 13370 21308 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 0.999765401398207 0.999452610763328 0.999923822225278 0.444444444444444 0.136995662265166 0.787991493221131 0 0 0.841886116991581 0 0 0.521823750104981 0 0 8.48669562756263 0.526195481491762 956.5 4479 False False 0 0 0 0 0 0 0 1.27497382198952 0.252954323547563 5.92545609271499 0 0 0.000275869155324334 0.999765401398207 0.999452610763328 0.999923822225278 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Tyr137Cys Rv1129c_p.Tyr137Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 3 20844 27465 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999890782000873 0.99968085216583 0.999977476056514 0.4 0.0527449505263169 0.853367200365326 0 0 0.975 0 0 0.707598226178713 0 0 51.3496104721628 1 2027.5 5574 False False 0.878430243715217 0.0733354884838472 7.66963698207431 0 0 0.000176959943030976 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 62.0858160113928 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Tyr137His Rv1129c_p.Tyr137His 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18880616510555 0.264079043314886 541.5 5574 False False 0.439194051331254 0.00837049629364692 5.4704842261679 0 0 0.000176951454458875 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 3 13373 21310 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999859240838924 0.999588697652472 0.999970971136275 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85680682534852 0.289279625558287 389.5 4479 False False 0 0 0 0 0 0 0 0.531169769934445 0.010122018243966 6.61631049307563 0 0 0.000275807277411719 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Tyr137Ser Rv1129c_p.Tyr137Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4244 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Tyr301His Rv1129c_p.Tyr301His 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01632529799099 0.509386028876591 1135.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48598624162872 0.526186417038858 925 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Tyr462Cys Rv1129c_p.Tyr462Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 3 20844 27465 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999890782000873 0.99968085216583 0.999977476056514 0.4 0.0527449505263169 0.853367200365326 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4264 5574 False False 0.878430243715217 0.0733354884838472 7.66963698207431 0 0 0.000176959943030976 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 3 13372 21310 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999859240838924 0.999588697652472 0.999970971136275 0.4 0.0527449505263169 0.853367200365326 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3420 4479 False False 0 0 0 0 0 0 0 1.06241898494366 0.0886985485353837 9.27715037564111 0 0 0.000275827900298067 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Tyr462His Rv1129c_p.Tyr462His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4362 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Tyr462Leu Rv1129c_p.Tyr462Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Val101Ile Rv1129c_p.Val101Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4330 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3476 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Val110Phe Rv1129c_p.Val110Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4295 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3443 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Val116Phe Rv1129c_p.Val116Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 1 20843 27467 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999963594000291 0.999797175631493 0.999999078280314 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 51.3558084523276 1 2027.5 5574 False False 3.95341361608213 0.31739219148065 207.323829234655 0 0 0.00017696843241753 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3398 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Val121Leu Rv1129c_p.Val121Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Val226Leu Rv1129c_p.Val226Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3426 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Val249Leu Rv1129c_p.Val249Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 7.01573328293188 0.509380354735251 864 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.48495357236853 0.526173219289417 690 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Val259Ala Rv1129c_p.Val259Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 2 6 20844 27462 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999781564001747 0.999524617886493 0.999919833755107 0.25 0.0318540262499442 0.650855794412824 0 0 0.602364635616474 0 0 0.4592581264399 0 0 1.99609422188366 0.139120378841242 337.5 5574 False False 0.439167146421032 0.0433460282809438 2.45619176778693 0 0 0.000176959943030976 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.41420404242617 0.305473156458586 444 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Val259Met Rv1129c_p.Val259Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Val272Ile Rv1129c_p.Val272Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Val272Phe Rv1129c_p.Val272Phe 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4296 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3444 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Val317Ala Rv1129c_p.Val317Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Val337Ala Rv1129c_p.Val337Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 10 1 20836 27467 0.000479708337330902 0.000230061997553563 0.000882023176671562 0.999963594000291 0.999797175631493 0.999999078280314 0.909090909090909 0.587220083011617 0.997701027786185 0 0 0.975 0 0 0.975 0 0 51.3730479462142 1 2027.5 5574 False False 13.1824726435016 1.87489573468025 570.603433894195 0 0 0.000177027880937939 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 4 1 13370 21312 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 0.999953080279641 0.999738608085756 0.999998812096234 0.8 0.28358206388191 0.994949236620532 0 0 0.975 0 0 0.975 0 0 62.1101953816142 1 1642.5 4479 False False 0 0 0 0 0 0 0 6.37606581899775 0.630846560224411 313.513380938872 0 0 0.000275869155324334 0.999953080279641 0.999738608085756 0.999998812096234 3 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Val337Leu Rv1129c_p.Val337Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 20846 27462 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.11900921779861 0.0402109359097128 194.5 5574 False False 0 0 1.11900921779861 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 13374 21307 0 0 0.000275786657608973 0.999718481677849 0.999387354605726 0.999896680954833 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.35335561005417 0.0884814409570568 164 4479 False False 0 0 0 0 0 0 0 0 0 1.35335561005417 0 0 0.000275786657608973 0.999718481677849 0.999387354605726 0.999896680954833 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Val337Phe Rv1129c_p.Val337Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4322 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3470 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Val34Leu Rv1129c_p.Val34Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 1.99597553667858 0.139114336996004 304.5 5574 False False 0 0 1.43785249906968 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Val359Ile Rv1129c_p.Val359Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Val359Leu Rv1129c_p.Val359Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4210 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3374 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Val394Met Rv1129c_p.Val394Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4282 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3435 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Val414Ile Rv1129c_p.Val414Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4348 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Val486Ala Rv1129c_p.Val486Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Val486Phe Rv1129c_p.Val486Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4401 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3531 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Val59Ala Rv1129c_p.Val59Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4221 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3384 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Val59Met Rv1129c_p.Val59Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Val6Ile Rv1129c_p.Val6Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 6 9 20840 27459 0.000287825002398541 0.000105633792978048 0.000626367784710498 0.999672346002621 0.99937810218515 0.999850165132458 0.4 0.163364323859513 0.677130233793718 0 0 0.521823750104981 0 0 0.336267116879942 0 0 1.43805763802963 0.0743502528713648 269 5574 False False 0.878406909788867 0.257238908183629 2.76363355184631 0 0 0.000176993905465082 0.999672346002621 0.99937810218515 0.999850165132458 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 5 2 13369 21311 0.000373859727830118 0.000121402023062639 0.000872246401868143 0.999906160559283 0.999661061221376 0.999988635406343 0.714285714285714 0.290420863737342 0.963307433823914 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48852531192879 0.526218871049245 973 4479 False False 0 0 0 0 0 0 0 3.98515221781733 0.652287032938702 41.8973624237223 0 0 0.000275889787465637 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Val85Leu Rv1129c_p.Val85Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Val85Met Rv1129c_p.Val85Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4404 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3533 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Val97Ala Rv1129c_p.Val97Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Val97Ile Rv1129c_p.Val97Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4356 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Val9fs Rv1129c_p.Val9fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4376 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3510 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1129c p.Val9Met Rv1129c_p.Val9Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4231 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3392 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c c.1002C>T Rv1258c_c.1002C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.1029T>C Rv1258c_c.1029T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 152 632 20694 26836 0.00729156672742972 0.00618177679522264 0.00854188900877672 0.976991408184068 0.975148856234286 0.978732082499652 0.193877551020408 0.166760328208681 0.223318911951723 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.311888849333201 0.259293000253408 0.373261008537149 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 136 602 13238 20711 0.0101689845969792 0.0085384987052836 0.0120175640337082 0.9717543283442029 0.969441266101772 0.973937487959626 0.184281842818428 0.156938986404146 0.214174538760326 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 0 0.353444403230607 0.290852343262954 0.42696986910155 NA NA NA NA NA NA 22 5) Not assoc w R Now listed Silent mutation no 0 +Isoniazid Rv1258c c.1038C>T Rv1258c_c.1038C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.1039C>A Rv1258c_c.1039C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.18865318395302 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.103T>C Rv1258c_c.103T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 13 20846 27455 0 0 0.00017694296670111 0.999526722003786 0.99919081619501 0.999747976101462 0 0 0.24705263800047 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.432228279580125 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 9 13374 21304 0 0 0.000275786657608973 0.999577722516773 0.999198537836033 0.999806890245066 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.80720191833017 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.1047C>T Rv1258c_c.1047C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.99604811372315 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.41420404242617 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.1059G>T Rv1258c_c.1059G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.1062G>A Rv1258c_c.1062G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.1065G>A Rv1258c_c.1065G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 7 2 20839 27466 0.000335795836131632 0.000135017659185429 0.000691744589626827 0.999927188000582 0.999737003036386 0.999991182007438 0.777777777777777 0.399906426283687 0.971855026522101 NA NA NA NA NA NA NA NA NA NA NA NA False False 4.61303325495465 0.87817476276209 45.5132476135674 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.1083G>A Rv1258c_c.1083G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.1086G>A Rv1258c_c.1086G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.1092G>A Rv1258c_c.1092G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.1107A>C Rv1258c_c.1107A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.1108C>T Rv1258c_c.1108C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.1110G>C Rv1258c_c.1110G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.1116C>T Rv1258c_c.1116C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.1125A>C Rv1258c_c.1125A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.1137G>T Rv1258c_c.1137G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.114G>A Rv1258c_c.114G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.1152A>G Rv1258c_c.1152A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.1153C>T Rv1258c_c.1153C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.1161C>T Rv1258c_c.1161C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.1170C>T Rv1258c_c.1170C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.1176G>T Rv1258c_c.1176G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 6 20 20840 27448 0.000287825002398541 0.000105633792978048 0.000626367784710498 0.999271880005825 0.998875700613314 0.999555190458412 0.23076923076923 0.0897401108845751 0.436475096941386 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.395124760076775 0.129826453761761 1.02038758267621 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 13 13371 21300 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.99939004363534 0.998957181904114 0.999675185224884 0.1875 0.0404737339059459 0.456456546231611 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.367615332838577 0.0671805522637574 1.33817896767753 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.1182G>C Rv1258c_c.1182G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.1188G>A Rv1258c_c.1188G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.1200G>T Rv1258c_c.1200G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.1203C>G Rv1258c_c.1203C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.658815063564403 0.011171855707321 12.6567401482543 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.1209G>A Rv1258c_c.1209G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.658815063564403 0.011171855707321 12.6567401482543 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.120C>T Rv1258c_c.120C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.43785249906968 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.41420404242617 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.1230C>T Rv1258c_c.1230C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.1251G>A Rv1258c_c.1251G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.129G>A Rv1258c_c.129G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.162G>T Rv1258c_c.162G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.165G>A Rv1258c_c.165G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.99604811372315 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.85651838973546 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.168G>A Rv1258c_c.168G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.18865318395302 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.85651838973546 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.-16T>A Rv1258c_c.-16T>A 2 upstream_gene_variant 1407356 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3775 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3018 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c c.-16T>C Rv1258c_c.-16T>C 2 upstream_gene_variant 1407356 1 3 0 3 10 8 20836 27460 0.000479708337330902 0.000230061997553563 0.000882023176671562 0.99970875200233 0.999426206431739 0.999874251669172 0.555555555555555 0.307571658998756 0.7846984926127 0 0 0.707598226178713 0 0 0.369416647552819 0 0 3.18960289609381 0.264104251026737 570 5574 False False 1.64738913419082 0.585284664799611 4.80431518739208 0 0 0.000177027880937939 0.99970875200233 0.999426206431739 0.999874251669172 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 5 4 13369 21309 0.000373859727830118 0.000121402023062639 0.000872246401868143 0.999812321118566 0.999519537882235 0.999948861529775 0.555555555555555 0.212008506778868 0.863004337734833 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.85777994929726 0.289320668487247 408 4479 False False 0 0 0 0 0 0 0 1.99238910913306 0.428746116317097 10.0429456178996 0 0 0.000275889787465637 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c c.171C>T Rv1258c_c.171C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.247471899512553 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.177G>A Rv1258c_c.177G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.186C>T Rv1258c_c.186C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.658815063564403 0.011171855707321 12.6567401482543 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.189C>T Rv1258c_c.189C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.195G>A Rv1258c_c.195G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.198C>T Rv1258c_c.198C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.658815063564403 0.011171855707321 12.6567401482543 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.-1C>T Rv1258c_c.-1C>T 2 upstream_gene_variant 1407341 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c c.207C>T Rv1258c_c.207C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.439194051331254 0.00837049629364692 5.4704842261679 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 3 13373 21310 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999859240838924 0.999588697652472 0.999970971136275 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.531169769934445 0.010122018243966 6.61631049307563 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.-22G>C Rv1258c_c.-22G>C 2 upstream_gene_variant 1407362 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance No change no 1 +Isoniazid Rv1258c c.231G>A Rv1258c_c.231G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.234C>T Rv1258c_c.234C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.-23C>T Rv1258c_c.-23C>T 2 upstream_gene_variant 1407363 NA 0 0 0 12 0 20834 27468 0.000575650004797083 0.000297481006307132 0.00100532857413147 1 0.999865711673152 1 1 0.735351530602948 1 NA NA NA NA NA NA NA NA NA NA 3817 5574 False False Inf 3.66300284077067 Inf 0 0 0.000177044873566246 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 5 0 13369 21313 0.000373859727830118 0.000121402023062639 0.000872246401868143 1 0.999826933785262 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 3055 4479 False False 0 0 0 0 0 0 0 Inf 1.46057233596553 Inf 0 0 0.000275889787465637 1 0.999826933785262 1 3 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c c.249T>C Rv1258c_c.249T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.24G>A Rv1258c_c.24G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.255G>A Rv1258c_c.255G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.-25G>A Rv1258c_c.-25G>A 2 upstream_gene_variant 1407365 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3783 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3026 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c c.-25G>T Rv1258c_c.-25G>T 2 upstream_gene_variant 1407365 NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3765 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3009 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c c.270C>T Rv1258c_c.270C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.271C>T Rv1258c_c.271C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.276G>A Rv1258c_c.276G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.18865318395302 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.279G>A Rv1258c_c.279G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 9 38 20837 27430 0.000431737503597812 0.000197436276106449 0.000819413341228355 0.998616572011067 0.998101626446224 0.999020823782757 0.191489361702127 0.0914915680081901 0.332597336833885 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.311780916032462 0.132536842382944 0.656198414876058 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 8 31 13366 21282 0.000598175564528189 0.000258283997825234 0.00117830226263269 0.998545488668887 0.997936067102158 0.999011522809834 0.205128205128205 0.0929639272829956 0.364644240695119 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.410902965154725 0.163146440334651 0.914203175973507 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.297C>T Rv1258c_c.297C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.247471899512553 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.303C>T Rv1258c_c.303C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.309G>A Rv1258c_c.309G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.-30G>A Rv1258c_c.-30G>A 2 upstream_gene_variant 1407370 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance No change no 1 +Isoniazid Rv1258c c.31C>T Rv1258c_c.31C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.334C>T Rv1258c_c.334C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.-33A>G Rv1258c_c.-33A>G 2 upstream_gene_variant 1407373 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3808 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3047 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c c.-33A>T Rv1258c_c.-33A>T 2 upstream_gene_variant 1407373 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3075 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c c.342C>T Rv1258c_c.342C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.351C>T Rv1258c_c.351C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.354G>A Rv1258c_c.354G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.439194051331254 0.00837049629364692 5.4704842261679 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 3 13373 21310 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999859240838924 0.999588697652472 0.999970971136275 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.531169769934445 0.010122018243966 6.61631049307563 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.357A>C Rv1258c_c.357A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.-36C>T Rv1258c_c.-36C>T 2 upstream_gene_variant 1407376 1 0 0 0 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3868 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3103 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c c.-36delC Rv1258c_c.-36delC 2 upstream_gene_variant 1407375 1 3 0 3 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18880616510555 0.264079043314886 541.5 5574 False False 0.439194051331254 0.00837049629364692 5.4704842261679 0 0 0.000176951454458875 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48598624162872 0.526186417038858 925 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c c.378G>A Rv1258c_c.378G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.384G>A Rv1258c_c.384G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.18865318395302 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.85651838973546 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.390G>A Rv1258c_c.390G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.39G>A Rv1258c_c.39G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.3G>A Rv1258c_c.3G>A 2 initiator_codon_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 7 20846 27461 0 0 0.00017694296670111 0.999745158002038 0.999474999027776 0.999897534357495 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.914121240039481 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 7 13374 21306 0 0 0.000275786657608973 0.99967156195749 0.999323409938814 0.999867941002665 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.10552510564584 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.405A>C Rv1258c_c.405A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.-40C>T Rv1258c_c.-40C>T 2 upstream_gene_variant 1407380 1 5 0 5 1 9 20845 27459 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999672346002621 0.99937810218515 0.999850165132458 0.1 0.00252857854446178 0.445016117028195 0 0 0.521823750104981 0 0 0.336267116879942 0 0 1.43771163944871 0.0743297104472869 229 5574 False False 0.146366035020388 0.00334344690875921 1.0564499909134 0 0 0.000176951454458875 0.999672346002621 0.99937810218515 0.999850165132458 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c c.-41G>A Rv1258c_c.-41G>A 2 upstream_gene_variant 1407381 NA 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3784 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3027 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c c.426C>T Rv1258c_c.426C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.-42G>A Rv1258c_c.-42G>A 2 upstream_gene_variant 1407382 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3836 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c c.444G>A Rv1258c_c.444G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 2 20844 27466 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999927188000582 0.999737003036386 0.999991182007438 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.3176933410094 0.0955278435529395 18.1762534351792 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.456G>A Rv1258c_c.456G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.459C>A Rv1258c_c.459C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.498G>A Rv1258c_c.498G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 6 20845 27462 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999781564001747 0.999524617886493 0.999919833755107 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.219573039098105 0.00477770915407814 1.81014820057657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.41420404242617 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.504T>A Rv1258c_c.504T>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 20846 27462 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.11900921779861 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.513C>T Rv1258c_c.513C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.51G>A Rv1258c_c.51G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.528T>C Rv1258c_c.528T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 29 0 20817 27468 0.00139115417825961 0.000931869577538548 0.00199732323166199 1 0.999865711673152 1 1 0.880555130930497 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 9.724633441073 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 24 0 13350 21313 0.00179452669358456 0.00115011499978073 0.00266894436176925 1 0.999826933785262 1 1 0.857526402277474 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 9.60550580369955 Inf NA NA NA NA NA NA 23 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.-52G>A Rv1258c_c.-52G>A 2 upstream_gene_variant 1407392 1 0 0 0 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3872 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3107 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c c.531C>G Rv1258c_c.531C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.534G>A Rv1258c_c.534G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.537G>A Rv1258c_c.537G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.-54C>G Rv1258c_c.-54C>G 2 upstream_gene_variant 1407394 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3818 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3056 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c c.552C>T Rv1258c_c.552C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.555C>T Rv1258c_c.555C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.579C>T Rv1258c_c.579C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.57G>A Rv1258c_c.57G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.594G>A Rv1258c_c.594G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.612G>A Rv1258c_c.612G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.633G>A Rv1258c_c.633G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.247471899512553 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.-64_-56delTGCGGCAGC Rv1258c_c.-64_-56delTGCGGCAGC 2 upstream_gene_variant 1407395 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c c.666G>A Rv1258c_c.666G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.63548263289195 0.137183409715989 155.34952410964 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.697C>T Rv1258c_c.697C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.69T>C Rv1258c_c.69T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 1 20843 27467 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999963594000291 0.999797175631493 0.999999078280314 0.75 0.194120449683243 0.99369053679029 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.95341361608213 0.31739219148065 207.323829234655 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.705C>A Rv1258c_c.705C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 2 20843 27466 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999927188000582 0.999737003036386 0.999991182007438 0.6 0.146632799634673 0.947255049473683 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.97663484143357 0.226402568392661 23.6672561646805 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.738G>A Rv1258c_c.738G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.741C>T Rv1258c_c.741C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.753C>T Rv1258c_c.753C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 20846 27462 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.11900921779861 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 5 13374 21308 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.73894646374006 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.771G>A Rv1258c_c.771G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.792G>A Rv1258c_c.792G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.804C>T Rv1258c_c.804C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.807C>G Rv1258c_c.807C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.813C>T Rv1258c_c.813C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.837C>A Rv1258c_c.837C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.837C>T Rv1258c_c.837C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.846T>G Rv1258c_c.846T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 7 20846 27461 0 0 0.00017694296670111 0.999745158002038 0.999474999027776 0.999897534357495 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.914121240039481 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 5 13374 21308 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.73894646374006 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.849C>A Rv1258c_c.849C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.99604811372315 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.41420404242617 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.852C>T Rv1258c_c.852C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.855T>G Rv1258c_c.855T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.882G>A Rv1258c_c.882G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 6 4 20840 27464 0.000287825002398541 0.000105633792978048 0.000626367784710498 0.999854376001165 0.999627187086024 0.999960320981843 0.6 0.262378076606945 0.878447741880172 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.9767754318618 0.468694569336888 9.5254553139328 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 6 0 13368 21313 0.000448631673396141 0.000164657143425453 0.000976224581517196 1 0.999826933785262 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.87681913692541 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.882G>C Rv1258c_c.882G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.885T>A Rv1258c_c.885T>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.-8C>A Rv1258c_c.-8C>A 2 upstream_gene_variant 1407348 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3853 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3088 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c c.-8C>T Rv1258c_c.-8C>T 2 upstream_gene_variant 1407348 1 2 0 2 9 2 20837 27466 0.000431737503597812 0.000197436276106449 0.000819413341228355 0.999927188000582 0.999737003036386 0.999991182007438 0.818181818181818 0.482244147639827 0.97716880170004 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01901914637982 0.509411861028927 1208 5574 False False 5.93161203628161 1.2275015406436 56.3622476535806 0 0 0.000177019385846931 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 1 13371 21312 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999953080279641 0.999738608085756 0.999998812096234 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 62.1055547471297 1 1642.5 4479 False False 0 0 0 0 0 0 0 4.78169172088849 0.383875689805931 250.696170545132 0 0 0.000275848526268708 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c c.900G>A Rv1258c_c.900G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 3 20842 27465 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999890782000873 0.99968085216583 0.999977476056514 0.571428571428571 0.184051567640083 0.901011721557492 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.75702907590442 0.297192930207644 11.9979296337129 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.915C>A Rv1258c_c.915C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.918G>A Rv1258c_c.918G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.247471899512553 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.918G>C Rv1258c_c.918G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.927G>A Rv1258c_c.927G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.930A>C Rv1258c_c.930A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.930A>G Rv1258c_c.930A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.247471899512553 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.939C>T Rv1258c_c.939C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.942C>T Rv1258c_c.942C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.949T>C Rv1258c_c.949T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.247471899512553 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.951G>A Rv1258c_c.951G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.960G>A Rv1258c_c.960G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.960G>T Rv1258c_c.960G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.967C>T Rv1258c_c.967C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.972G>A Rv1258c_c.972G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.972G>T Rv1258c_c.972G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.975C>T Rv1258c_c.975C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.978A>G Rv1258c_c.978A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 20846 27462 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.11900921779861 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 5 13374 21308 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.73894646374006 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.981C>T Rv1258c_c.981C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 3 20843 27465 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999890782000873 0.99968085216583 0.999977476056514 0.5 0.118117248757025 0.881882751242974 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31770858321738 0.176469385678871 9.83712695959095 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 3 13372 21310 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999859240838924 0.999588697652472 0.999970971136275 0.4 0.0527449505263169 0.853367200365326 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.06241898494366 0.0886985485353837 9.27715037564111 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.987G>A Rv1258c_c.987G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c c.99G>A Rv1258c_c.99G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv1258c deletion Rv1258c_deletion 2 feature_ablation (see "Genomic_coordinates" sheet) NA 0 0 0 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3792 5574 False False 0.439194051331254 0.00837049629364692 5.4704842261679 0 0 0.000176951454458875 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 3 13373 21310 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999859240838924 0.999588697652472 0.999970971136275 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3034 4479 False False 0 0 0 0 0 0 0 0.531169769934445 0.010122018243966 6.61631049307563 0 0 0.000275807277411719 0.999859240838924 0.999588697652472 0.999970971136275 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c LoF Rv1258c_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 4221 178 4043 8886 5293 11960 22175 0.42626882855224 0.419542267656559 0.433015958939574 0.807303043541575 0.802588093860727 0.811952900790064 0.626701459905494 0.618679549788093 0.634671345745534 0.0421701018715944 0.0363075095513759 0.0486764277135178 0.0325351855236702 0.0279933545877155 0.0375841004153684 0.0816297957492077 0.0697528833930084 0.0950345129054921 0 1.5 5574 True False 3.11269711937328 2.98799995233089 3.24253511733403 0.0146646894051738 0.0126020271748497 0.0169646299100511 0.807303043541575 0.802588093860727 0.811952900790064 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2892 115 2777 5495 3600 7879 17713 0.410871840885299 0.402516343704978 0.419266139875624 0.83108900670952 0.825990357549464 0.836097182958924 0.604178119846069 0.594040777042786 0.614248687947569 0.0397648686030428 0.0329395059298761 0.0475402080510841 0.0309555854643337 0.0256231992211393 0.0370416304256786 0.0930985641076595 0.0764367647934224 0.112445444168296 1.04771979265289e-272 2 4479 True False 0 0 0 0 0 0 0 3.43151750081087 3.26399966362097 3.60735141113611 0.0143857893420065 0.0118911642797585 0.017243013323681 0.83108900670952 0.825990357549464 0.836097182958924 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Ala113Glu Rv1258c_p.Ala113Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3857 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3091 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Ala113Val Rv1258c_p.Ala113Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Ala115fs Rv1258c_p.Ala115fs 2 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3827 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3063 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Ala123Val Rv1258c_p.Ala123Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3816 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Ala135Thr Rv1258c_p.Ala135Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Ala148Thr Rv1258c_p.Ala148Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3828 5574 False False 0.439194051331254 0.00837049629364692 5.4704842261679 0 0 0.000176951454458875 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3064 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Ala15Thr Rv1258c_p.Ala15Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Ala166Gly Rv1258c_p.Ala166Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Ala166Thr Rv1258c_p.Ala166Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Ala178Val Rv1258c_p.Ala178Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Ala180Thr Rv1258c_p.Ala180Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Ala187Thr Rv1258c_p.Ala187Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Ala190Thr Rv1258c_p.Ala190Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Ala196Gly Rv1258c_p.Ala196Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Ala19Thr Rv1258c_p.Ala19Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3819 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Ala19Val Rv1258c_p.Ala19Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Ala237Gly Rv1258c_p.Ala237Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Ala237Val Rv1258c_p.Ala237Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 9 0 9 10 11 20836 27457 0.000479708337330902 0.000230061997553563 0.000882023176671562 0.999599534003203 0.9992835689522 0.999800072407065 0.476190476190476 0.257130626406406 0.702193161216357 0 0 0.336267116879942 0 0 0.284914152918154 0 0 0.667720435745551 0.0128606763617543 135 5574 False False 1.19797029616572 0.45602498908634 3.10782564654157 0 0 0.000177027880937939 0.999599534003203 0.9992835689522 0.999800072407065 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 10 11 13364 21302 0.000747719455660236 0.000358616922835118 0.00137465137870696 0.999483883076056 0.999076712346733 0.999742329032819 0.476190476190476 0.257130626406406 0.702193161216357 0 0 0.336267116879942 0 0 0.284914152918154 0 0 0.807730124411823 0.0153798649510921 105 4479 False False 0 0 0 0 0 0 0 1.44907621561318 0.551557577905746 3.75916640067664 0 0 0.000275992994481552 0.999483883076056 0.999076712346733 0.999742329032819 1 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Ala266Val Rv1258c_p.Ala266Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Ala275Val Rv1258c_p.Ala275Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.18853708762714 0.264070532102877 442 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.85633740727807 0.289259828934126 294 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 1 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Ala282Gly Rv1258c_p.Ala282Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Ala294Ser Rv1258c_p.Ala294Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Ala294Val Rv1258c_p.Ala294Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3788 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3030 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Ala29Glu Rv1258c_p.Ala29Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 26 0 20820 27468 0.00124724167706034 0.000814896390023582 0.00182696777478964 1 0.999865711673152 1 1 0.867725395502245 1 NA NA NA NA NA NA NA NA NA NA 3840 5574 False False Inf 8.65294674151677 Inf 0 0 0.00017716391336717 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 24 0 13350 21313 0.00179452669358456 0.00115011499978073 0.00266894436176925 1 0.999826933785262 1 1 0.857526402277474 1 NA NA NA NA NA NA NA NA NA NA 3076 4479 False False 0 0 0 0 0 0 0 Inf 9.60550580369955 Inf 0 0 0.000276282385351184 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Ala29Val Rv1258c_p.Ala29Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Ala301Thr Rv1258c_p.Ala301Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Ala306Val Rv1258c_p.Ala306Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Ala319Glu Rv1258c_p.Ala319Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Ala341dup Rv1258c_p.Ala341dup 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3876 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3111 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Ala341Pro Rv1258c_p.Ala341Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3760 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Ala358Thr Rv1258c_p.Ala358Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Ala367Gly Rv1258c_p.Ala367Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Ala367Thr Rv1258c_p.Ala367Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 24 1 23 13 30 20833 27438 0.000623620838530173 0.000332092285535748 0.00106617452923529 0.998907820008737 0.998441209231564 0.999262993209016 0.302325581395348 0.171824992485213 0.461253305734032 0.0416666666666666 0.00105435244546974 0.211201683456973 0.032258064516129 0.000816370071846613 0.167021116230227 0.0572628292487462 0.0013943760785395 0.352706772276933 3.38142494180904e-05 53 5574 True False 0.570719531512504 0.273185729076787 1.12790814110923 4.79984640491504e-05 1.21521515796269e-06 0.00026740098547304 0.998907820008737 0.998441209231564 0.999262993209016 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 15 0 15 7 20 13367 21293 0.000523403618962165 0.000210460468745924 0.00107811225334149 0.99906160559283 0.998551096167295 0.999426713067202 0.259259259259259 0.111144562845442 0.462848742276171 0 0 0.218019360910534 0 0 0.168433470983085 0 0 0.444227167903897 0.000850990106670113 54 4479 False False 0 0 0 0 0 0 0 0.55753347796813 0.199132386290926 1.37309244138454 0 0 0.000275931061008045 0.99906160559283 0.998551096167295 0.999426713067202 11 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Ala367Val Rv1258c_p.Ala367Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3811 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3051 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Ala373Val Rv1258c_p.Ala373Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Ala374Pro Rv1258c_p.Ala374Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 32 0 32 8 41 20838 27427 0.000383766669864722 0.000165697303700768 0.000756032532322191 0.998507354011941 0.997975596204967 0.998928645116862 0.163265306122448 0.0732227599079882 0.296571357999703 0 0 0.108881160679352 0 0 0.0860438362940284 0 0 0.160855135508094 1.595614030723e-08 23 5574 True False 0.256819740670772 0.104000452900592 0.55509600308982 0 0 0.000177010891571197 0.998507354011941 0.997975596204967 0.998928645116862 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 26 0 26 8 32 13366 21281 0.000598175564528189 0.000258283997825234 0.00117830226263269 0.998498568948529 0.997881082537686 0.998972802621471 0.2 0.0905224093999906 0.356478018679234 0 0 0.132274604497754 0 0 0.108881160679352 0 0 0.242786553525978 5.00108709420025e-06 24 4479 True False 0 0 0 0 0 0 0 0.398043543318868 0.1584294036011 0.882352287401258 0 0 0.000275951702410535 0.998498568948529 0.997881082537686 0.998972802621471 8 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Ala374Thr Rv1258c_p.Ala374Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3767 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3011 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Ala374Val Rv1258c_p.Ala374Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Ala378Val Rv1258c_p.Ala378Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3812 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3052 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Ala394Thr Rv1258c_p.Ala394Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3789 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3031 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Ala399Val Rv1258c_p.Ala399Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 14 0 14 12 15 20834 27453 0.000575650004797083 0.000297481006307132 0.00100532857413147 0.999453910004368 0.999099467294252 0.999694326386446 0.444444444444444 0.254798806631737 0.646735769677994 0 0 0.231635761650116 0 0 0.218019360910534 0 0 0.397283547468953 0.000519137381729484 69 5574 True False 1.05416146683306 0.450443160789066 2.41292353944822 0 0 0.000177044873566246 0.999453910004368 0.999099467294252 0.999694326386446 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 7 11 13367 21302 0.000523403618962165 0.000210460468745924 0.00107811225334149 0.999483883076056 0.999076712346733 0.999742329032819 0.388888888888888 0.172985854789751 0.642548794106937 0 0 0.30849710781876 0 0 0.284914152918154 0 0 0.711104546435576 0.00890233816877152 81 4479 False False 0 0 0 0 0 0 0 1.01412569625332 0.333250573129895 2.86552930260106 0 0 0.000275931061008045 0.999483883076056 0.999076712346733 0.999742329032819 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Ala409Thr Rv1258c_p.Ala409Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3807 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3046 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Ala418Asp Rv1258c_p.Ala418Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3864 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3098 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Ala418Ser Rv1258c_p.Ala418Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Ala41Gly Rv1258c_p.Ala41Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Ala48Thr Rv1258c_p.Ala48Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Ala58Ser Rv1258c_p.Ala58Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3850 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3086 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Ala65Thr Rv1258c_p.Ala65Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 2 3 20844 27465 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999890782000873 0.99968085216583 0.999977476056514 0.4 0.0527449505263169 0.853367200365326 0 0 0.841886116991581 0 0 0.707598226178713 0 0 7.01640646205629 0.50938680646308 1153.5 5574 False False 0.878430243715217 0.0733354884838472 7.66963698207431 0 0 0.000176959943030976 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 2 3 13372 21310 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999859240838924 0.999588697652472 0.999970971136275 0.4 0.0527449505263169 0.853367200365326 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.48622266823901 0.526189438000421 944 4479 False False 0 0 0 0 0 0 0 1.06241898494366 0.0886985485353837 9.27715037564111 0 0 0.000275827900298067 0.999859240838924 0.999588697652472 0.999970971136275 1 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Ala78fs Rv1258c_p.Ala78fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3768 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3012 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Ala78Thr Rv1258c_p.Ala78Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3858 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3092 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Ala78Val Rv1258c_p.Ala78Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3877 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3112 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Ala80Val Rv1258c_p.Ala80Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 1.99604811372315 0.139118032244638 322.5 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.41420404242617 0.305473156458586 444 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Ala84Thr Rv1258c_p.Ala84Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3769 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Arg141Leu Rv1258c_p.Arg141Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3785 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3028 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Arg217_Thr252delinsPro Rv1258c_p.Arg217_Thr252delinsPro 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Arg223Trp Rv1258c_p.Arg223Trp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3776 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3019 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Arg345Cys Rv1258c_p.Arg345Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 4 1 20842 27467 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999963594000291 0.999797175631493 0.999999078280314 0.8 0.28358206388191 0.994949236620532 0 0 0.975 0 0 0.975 0 0 51.3582705287504 1 2027.5 5574 False False 5.27147106803569 0.521589398427432 259.279173455301 0 0 0.000176976922618654 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Arg347Gln Rv1258c_p.Arg347Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3761 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3005 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Arg396Trp Rv1258c_p.Arg396Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Arg401Gly Rv1258c_p.Arg401Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Arg401His Rv1258c_p.Arg401His 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Arg6Cys Rv1258c_p.Arg6Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3865 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3099 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Arg71His Rv1258c_p.Arg71His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3820 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3057 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Arg71Leu Rv1258c_p.Arg71Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3793 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Asn151Asp Rv1258c_p.Asn151Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Asn151Lys Rv1258c_p.Asn151Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Asn221Ser Rv1258c_p.Asn221Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3841 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3077 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Asn333Thr Rv1258c_p.Asn333Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3833 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3069 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Asn3Lys Rv1258c_p.Asn3Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Asn5fs Rv1258c_p.Asn5fs 2 frameshift (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.18853708762714 0.264070532102877 442 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Asp125fs Rv1258c_p.Asp125fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3837 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3072 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Asp125Glu Rv1258c_p.Asp125Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Asp232Glu Rv1258c_p.Asp232Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 1.99604811372315 0.139118032244638 322.5 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 2 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Asp23Gly Rv1258c_p.Asp23Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3873 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3108 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Asp23Val Rv1258c_p.Asp23Val 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 33 20842 27435 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.998798602009611 0.998313200429948 0.999172873081023 0.108108108108108 0.0302519650687496 0.254175936077478 NA NA NA 0 0 0.105762810074579 NA NA NA NA 3790 5574 False False 0.159555443117481 0.0410590562895431 0.448719890270696 0 0 0.000176976922618654 0.998798602009611 0.998313200429948 0.999172873081023 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 32 13370 21281 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 0.998498568948529 0.997881082537686 0.998972802621471 0.111111111111111 0.0311161399450152 0.260610920510829 NA NA NA 0 0 0.108881160679352 NA NA NA NA 3032 4479 False False 0 0 0 0 0 0 0 0.198962228870605 0.051136874291147 0.561223621726516 0 0 0.000275869155324334 0.998498568948529 0.997881082537686 0.998972802621471 2 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Asp253Glu Rv1258c_p.Asp253Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3777 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3020 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Asp410Asn Rv1258c_p.Asp410Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3851 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Asp67Asn Rv1258c_p.Asp67Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.18853708762714 0.264070532102877 442 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.85633740727807 0.289259828934126 294 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Asp79Asn Rv1258c_p.Asp79Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Asp99Glu Rv1258c_p.Asp99Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Gln206His Rv1258c_p.Gln206His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Gln206Leu Rv1258c_p.Gln206Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Gln255His Rv1258c_p.Gln255His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Gln259Leu Rv1258c_p.Gln259Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 5 0 20841 27468 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 1 0.999865711673152 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 3874 5574 False False Inf 1.20760984683633 Inf 0 0 0.000176985413634466 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3109 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Gln329* Rv1258c_p.Gln329* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Gln337Pro Rv1258c_p.Gln337Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 7.01573328293188 0.509380354735251 864 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 1 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Gln419Arg Rv1258c_p.Gln419Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 11 0 11 0 12 20846 27456 0 0 0.00017694296670111 0.999563128003495 0.99923699702714 0.999774242139628 0 0 0.264648469397051 0 0 0.284914152918154 0 0 0.264648469397051 0 0 0.524850250181136 0.00349739395257092 99 5574 False False 0 0 0.474072891853425 0 0 0.00017694296670111 0.999563128003495 0.99923699702714 0.999774242139628 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 0 10 13374 21303 0 0 0.000275786657608973 0.999530802796415 0.99913729947772 0.999774979505452 0 0 0.30849710781876 0 0 0.336267116879942 0 0 0.30849710781876 0 0 0.807164035491041 0.0153587769129713 99 4479 False False 0 0 0 0 0 0 0 0 0 0.710765762832934 0 0 0.000275786657608973 0.999530802796415 0.99913729947772 0.999774979505452 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Gln43His Rv1258c_p.Gln43His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Glu130fs Rv1258c_p.Glu130fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3848 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3084 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Glu194Asp Rv1258c_p.Glu194Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01632529799099 0.509386028876591 1135.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Glu194fs Rv1258c_p.Glu194fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 8848 5193 11998 22275 0.424445936870382 0.417723365845798 0.431189585991358 0.81094364351245 0.806262169372729 0.815559251602481 0.630154547396909 0.622107477516899 0.638147647810911 NA NA NA 0 0 0.000710103900482466 NA NA NA NA 3842 5574 False True 3.16326551247853 3.03626122838381 3.29570235284489 0 0 0.000307410603828048 0.81094364351245 0.806262169372729 0.815559251602481 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 5469 3517 7905 17796 0.408927770300583 0.400578731307932 0.417316457620494 0.834983343499272 0.829930842399776 0.839944302279009 0.608613398620075 0.598432762013114 0.618723569277492 NA NA NA 0 0 0.00104832116886359 NA NA NA NA 3078 4479 False True 0 1 1 0 0 0 0 3.50070953822016 3.32915643947677 3.68156277070711 0 0 0.000466542552507196 0.834983343499272 0.829930842399776 0.839944302279009 1177 5) Not assoc w R New NotAwR yes 5 +Isoniazid Rv1258c p.Glu214Asp Rv1258c_p.Glu214Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Glu214Lys Rv1258c_p.Glu214Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3824 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3061 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Glu243Ala Rv1258c_p.Glu243Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 52 20844 27416 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.998106888015144 0.997518167363423 0.998585820163089 0.037037037037037 0.00451725629446049 0.127471772230947 NA NA NA 0 0 0.0684822087033195 NA NA NA NA NA NA False True 0.0505882526607915 0.00597629271071448 0.192207095360971 0 0 0.000176959943030976 0.998106888015144 0.997518167363423 0.998585820163089 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 48 13374 21265 0 0 0.000275786657608973 0.997747853422793 0.997015076381681 0.998338992326197 0 0 0.0739727853472802 NA NA NA 0 0 0.0739727853472802 NA NA NA NA NA NA False True 1 1 1 0 0 1 0 0 0 0.127046990998762 0 0 0.000275786657608973 0.997747853422793 0.997015076381681 0.998338992326197 4 Not assoc w R 5) Not assoc w R No change yes 1 +Isoniazid Rv1258c p.Glu38fs Rv1258c_p.Glu38fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Glu38Lys Rv1258c_p.Glu38Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Glu402Ala Rv1258c_p.Glu402Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Glu402Gln Rv1258c_p.Glu402Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3825 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Gly136Ser Rv1258c_p.Gly136Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Gly161Ser Rv1258c_p.Gly161Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01632529799099 0.509386028876591 1135.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48598624162872 0.526186417038858 925 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Gly195Asp Rv1258c_p.Gly195Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 2 2 3 2 20843 27466 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999927188000582 0.999737003036386 0.999991182007438 0.6 0.146632799634673 0.947255049473683 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 1.31775656095571 0.0955324245640855 18.1771259836516 1 2027.5 5574 False False 1.97663484143357 0.226402568392661 23.6672561646805 9.59462700887503e-05 1.16197496419179e-05 0.000346547484278011 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.796792043670081 0.0135099696349484 15.307558728263 1 1642.5 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 1 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Gly207Arg Rv1258c_p.Gly207Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Gly211Arg Rv1258c_p.Gly211Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Gly215Ala Rv1258c_p.Gly215Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3826 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3062 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Gly229Arg Rv1258c_p.Gly229Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3821 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3058 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Gly24Asp Rv1258c_p.Gly24Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3843 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3079 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Gly24Cys Rv1258c_p.Gly24Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 18 0 18 6 21 20840 27447 0.000287825002398541 0.000105633792978048 0.000626367784710498 0.999235474006116 0.998831576963824 0.999526686034611 0.222222222222222 0.0862169399475667 0.422583060044378 0 0 0.185301968137852 0 0 0.161097615219079 0 0 0.299581748645031 4.50764298135472e-05 58 5574 True False 0.376295585412667 0.124244375343298 0.96411971463875 0 0 0.000176993905465082 0.999235474006116 0.998831576963824 0.999526686034611 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 17 0 17 5 19 13369 21294 0.000373859727830118 0.000121402023062639 0.000872246401868143 0.999108525313189 0.998608200368116 0.999463191365845 0.208333333333333 0.0713186171980549 0.421512843637252 0 0 0.195064322969093 0 0 0.176466911806965 0 0 0.386057724168429 0.000539345456249749 49 4479 True False 0 0 0 0 0 0 0 0.419155075961277 0.122293676445795 1.16099067745706 0 0 0.000275889787465637 0.999108525313189 0.998608200368116 0.999463191365845 2 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Gly271del Rv1258c_p.Gly271del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3791 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3033 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Gly277Ala Rv1258c_p.Gly277Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Gly277Arg Rv1258c_p.Gly277Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Gly346Asp Rv1258c_p.Gly346Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 3786 5574 False False 0 0 1.43785249906968 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Gly360Arg Rv1258c_p.Gly360Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3771 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3014 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Gly360Asp Rv1258c_p.Gly360Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Gly360Ser Rv1258c_p.Gly360Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Gly363Val Rv1258c_p.Gly363Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 68 2 66 9 71 20837 27397 0.000431737503597812 0.000197436276106449 0.000819413341228355 0.997415174020678 0.996740695513369 0.997980694393485 0.1125 0.0527515131456875 0.20284659191699 0.0294117647058823 0.00358196142027139 0.102241011928118 0.0273972602739726 0.00333532889311666 0.0954891638377891 0.0398431694203638 0.00474437529511313 0.149774277938588 3.86683835052348e-14 11 5574 True False 0.166667905885183 0.0732196791609578 0.334696131466819 9.59738951005326e-05 1.162309528065e-05 0.000346647250305642 0.997415174020678 0.996740695513369 0.997980694393485 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 53 1 52 6 55 13368 21258 0.000448631673396141 0.000164657143425453 0.000976224581517196 0.997419415380284 0.996642322195326 0.998055376884694 0.0983606557377049 0.0369599948778518 0.20189619185437 0.0188679245283018 0.000477580412422113 0.100701526769146 0.0178571428571428 0.000452001530520825 0.0955259026323396 0.0305810661510841 0.00076428287836385 0.178119921316509 2.44399326261588e-10 11 4479 True False 0 0 0 0 0 0 0 0.173478047984331 0.0610203326452612 0.402444961125462 7.47999102401077e-05 1.89376797152033e-06 0.000416687175469531 0.997419415380284 0.996642322195326 0.998055376884694 3 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Gly375Ala Rv1258c_p.Gly375Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Gly375Arg Rv1258c_p.Gly375Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3796 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3037 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Gly391Arg Rv1258c_p.Gly391Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 2 7 20844 27461 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999745158002038 0.999474999027776 0.999897534357495 0.222222222222222 0.0281449734778982 0.600093573716312 0 0 0.4592581264399 0 0 0.409616397225003 0 0 1.11907584135889 0.0402148300153378 210 5574 False False 0.376415275379005 0.0381509889597215 1.97729867984898 0 0 0.000176959943030976 0.999745158002038 0.999474999027776 0.999897534357495 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 3 13373 21310 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999859240838924 0.999588697652472 0.999970971136275 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.48558807285294 0.526181327783453 903.5 4479 False False 0 0 0 0 0 0 0 0.531169769934445 0.010122018243966 6.61631049307563 0 0 0.000275807277411719 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Gly42fs Rv1258c_p.Gly42fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 2 4 20844 27464 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999854376001165 0.999627187086024 0.999960320981843 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.841886116991581 0 0 0.602364635616474 0 0 7.01615100815696 0.509384357655263 1115 5574 False False 0.658798695068125 0.0595601499680727 4.59736120623929 0 0 0.000176959943030976 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 2 3 13372 21310 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999859240838924 0.999588697652472 0.999970971136275 0.4 0.0527449505263169 0.853367200365326 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.48622266823901 0.526189438000421 944 4479 False False 0 0 0 0 0 0 0 1.06241898494366 0.0886985485353837 9.27715037564111 0 0 0.000275827900298067 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Gly70Arg Rv1258c_p.Gly70Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.31767810026385 0.0167927522337569 103.35711725526 1 1253.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Gly7Ser Rv1258c_p.Gly7Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3772 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3015 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Gly83Arg Rv1258c_p.Gly83Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Gly88fs Rv1258c_p.Gly88fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 20 58 20826 27410 0.000959416674661805 0.000586132014909014 0.00148135424594851 0.997888452016892 0.997271178461667 0.99839623461966 0.256410256410256 0.164189719614018 0.367858243460692 NA NA NA 0 0 0.0616210089039198 NA NA NA NA 3778 5574 False True 0.453842511184626 0.258490628936699 0.766195979904258 0 0 0.000177112876713918 0.997888452016892 0.997271178461667 0.99839623461966 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 17 49 13357 21264 0.0012711230746224 0.000740644897312986 0.00203441363276193 0.997700933702435 0.996961638022173 0.998298668901441 0.257575757575757 0.157766379257312 0.38006124067347 NA NA NA 0 0 0.0725192636642774 NA NA NA NA 3021 4479 False True 0 1 1 0 0 0 0 0.552317595451746 0.29807821433936 0.976479619881076 0 0 0.000276137614096336 0.997700933702435 0.996961638022173 0.998298668901441 6 5) Not assoc w R New NotAwR yes 5 +Isoniazid Rv1258c p.Gly95Arg Rv1258c_p.Gly95Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Gly95Glu Rv1258c_p.Gly95Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3854 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3089 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Gly97Asp Rv1258c_p.Gly97Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3813 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3053 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Gly98del Rv1258c_p.Gly98del 2 inframe_deletion (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3814 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3054 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.His254Arg Rv1258c_p.His254Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Ile12Val Rv1258c_p.Ile12Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3859 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3093 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Ile155Thr Rv1258c_p.Ile155Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3878 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3113 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Ile185Thr Rv1258c_p.Ile185Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3849 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3085 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Ile188fs Rv1258c_p.Ile188fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Ile27Val Rv1258c_p.Ile27Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3860 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3094 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Ile283Ser Rv1258c_p.Ile283Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3879 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3114 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Ile283Val Rv1258c_p.Ile283Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 2 2 20844 27466 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999927188000582 0.999737003036386 0.999991182007438 0.5 0.067585986488543 0.932414013511457 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01666191595533 0.509389255488555 1161.5 5574 False False 1.3176933410094 0.0955278435529395 18.1762534351792 0 0 0.000176959943030976 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3048 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Ile314Thr Rv1258c_p.Ile314Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 1.99604811372315 0.139118032244638 322.5 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.41420404242617 0.305473156458586 444 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Ile411Val Rv1258c_p.Ile411Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3809 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3049 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Leu106Pro Rv1258c_p.Leu106Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3787 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3029 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Leu109Phe Rv1258c_p.Leu109Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Leu128Arg Rv1258c_p.Leu128Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3880 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3115 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Leu13Arg Rv1258c_p.Leu13Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Leu150Phe Rv1258c_p.Leu150Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3881 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3116 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Leu183fs Rv1258c_p.Leu183fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Leu193_Glu194insValGlnLeu Rv1258c_p.Leu193_Glu194insValGlnLeu 2 inframe_insertion (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3866 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3100 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Leu193Pro Rv1258c_p.Leu193Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3762 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3006 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Leu222Val Rv1258c_p.Leu222Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Leu238Arg Rv1258c_p.Leu238Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Leu240Arg Rv1258c_p.Leu240Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 29 0 29 0 36 20846 27432 0 0 0.00017694296670111 0.998689384010484 0.998186012178885 0.999081897081075 0 0 0.0973937559144919 0 0 0.119444869069502 0 0 0.0973937559144919 0 0 0.17853211147033 9.56990483758431e-08 25 5574 True False 0 0 0.142020420580488 0 0 0.00017694296670111 0.998689384010484 0.998186012178885 0.999081897081075 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 28 0 28 0 35 13374 21278 0 0 0.000275786657608973 0.998357809787453 0.997716843861875 0.998855896017746 0 0 0.100032435572105 0 0 0.123436118500263 0 0 0.100032435572105 0 0 0.224118776125588 1.55714785070411e-06 22 4479 True False 0 0 0 0 0 0 0 0 0 0.176884140273717 0 0 0.000275786657608973 0.998357809787453 0.997716843861875 0.998855896017746 2 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Leu240Pro Rv1258c_p.Leu240Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Leu296Val Rv1258c_p.Leu296Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Leu300fs Rv1258c_p.Leu300fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3801 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Leu355Pro Rv1258c_p.Leu355Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Leu35fs Rv1258c_p.Leu35fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3763 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3007 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Leu35Ser Rv1258c_p.Leu35Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Leu365Ser Rv1258c_p.Leu365Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Leu370Pro Rv1258c_p.Leu370Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3810 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3050 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Leu376fs Rv1258c_p.Leu376fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 6 0 20840 27468 0.000287825002398541 0.000105633792978048 0.000626367784710498 1 0.999865711673152 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 3870 5574 False False Inf 1.55167078958407 Inf 0 0 0.000176993905465082 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 6 0 13368 21313 0.000448631673396141 0.000164657143425453 0.000976224581517196 1 0.999826933785262 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 3105 4479 False False 0 0 0 0 0 0 0 Inf 1.87681913692541 Inf 0 0 0.00027591042269331 1 0.999826933785262 1 3 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Leu381fs Rv1258c_p.Leu381fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Leu397Val Rv1258c_p.Leu397Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Leu60Val Rv1258c_p.Leu60Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3882 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Lys198_Pro205delinsThr Rv1258c_p.Lys198_Pro205delinsThr 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3797 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3038 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Lys249fs Rv1258c_p.Lys249fs 2 frameshift (see "Genomic_coordinates" sheet) 1 6 0 6 1 10 20845 27458 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999635940002912 0.999330582956894 0.999825405716755 0.0909090909090909 0.00229897221381426 0.412779916988382 0 0 0.4592581264399 0 0 0.30849710781876 0 0 1.11889992439267 0.0402045481045069 181.5 5574 False False 0.131724634204845 0.00303942055735959 0.926075505001071 0 0 0.000176951454458875 0.999635940002912 0.999330582956894 0.999825405716755 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 10 13374 21303 0 0 0.000275786657608973 0.999530802796415 0.99913729947772 0.999774979505452 0 0 0.30849710781876 0 0 0.4592581264399 0 0 0.30849710781876 0 0 1.35310166397741 0.0884761941542541 152.5 4479 False False 0 0 0 0 0 0 0 0 0 0.710765762832934 0 0 0.000275786657608973 0.999530802796415 0.99913729947772 0.999774979505452 1 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Met121Ile Rv1258c_p.Met121Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3773 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3016 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Met121Val Rv1258c_p.Met121Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 1 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Met127Arg Rv1258c_p.Met127Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3871 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3106 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Met18Thr Rv1258c_p.Met18Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3764 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3008 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Met230Thr Rv1258c_p.Met230Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3822 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3059 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Met230Val Rv1258c_p.Met230Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Met242fs Rv1258c_p.Met242fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 2 2 20844 27466 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999927188000582 0.999737003036386 0.999991182007438 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3845 5574 False False 1.3176933410094 0.0955278435529395 18.1762534351792 0 0 0.000176959943030976 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3081 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Met242Ile Rv1258c_p.Met242Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18880616510555 0.264079043314886 541.5 5574 False False 0.439194051331254 0.00837049629364692 5.4704842261679 0 0 0.000176951454458875 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Met242Thr Rv1258c_p.Met242Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Met291Arg Rv1258c_p.Met291Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3838 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3073 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Met303Arg Rv1258c_p.Met303Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3770 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3013 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Met315Ile Rv1258c_p.Met315Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3779 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3022 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Met352Ile Rv1258c_p.Met352Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Met52Ile Rv1258c_p.Met52Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Met76Val Rv1258c_p.Met76Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3802 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3042 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Phe154Val Rv1258c_p.Phe154Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Phe218Val Rv1258c_p.Phe218Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3780 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3023 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Phe251fs Rv1258c_p.Phe251fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3766 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3010 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Pro118Gln Rv1258c_p.Pro118Gln 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 3861 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3095 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Pro129Arg Rv1258c_p.Pro129Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.43785249906968 0.0743380732312645 251 5574 False False 0 0 1.43785249906968 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 13374 21308 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.73894646374006 0.163960020972012 248.5 4479 False False 0 0 0 0 0 0 0 0 0 1.73894646374006 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 1 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Pro129fs Rv1258c_p.Pro129fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 4 2 20842 27466 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999927188000582 0.999737003036386 0.999991182007438 0.666666666666666 0.222778095503512 0.956728131707258 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01733524879011 0.509395710775307 1192 5574 False False 2.63563957393724 0.377684835565828 29.1411399702847 0 0 0.000176976922618654 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Pro129His Rv1258c_p.Pro129His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Pro199fs Rv1258c_p.Pro199fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Pro199Ser Rv1258c_p.Pro199Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3829 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3065 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Pro241Leu Rv1258c_p.Pro241Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Pro241Ser Rv1258c_p.Pro241Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Pro248Thr Rv1258c_p.Pro248Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Pro257Leu Rv1258c_p.Pro257Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3101 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Pro312Ser Rv1258c_p.Pro312Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Pro330Gln Rv1258c_p.Pro330Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3794 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3035 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Pro330Ser Rv1258c_p.Pro330Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Pro361Leu Rv1258c_p.Pro361Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3862 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3096 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Pro361Ser Rv1258c_p.Pro361Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3852 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3087 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Pro369Gln Rv1258c_p.Pro369Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3839 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3074 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Pro369Thr Rv1258c_p.Pro369Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 9 1 8 9 8 20837 27460 0.000431737503597812 0.000197436276106449 0.000819413341228355 0.99970875200233 0.999426206431739 0.999874251669172 0.529411764705882 0.278118300331106 0.770167312734009 0.111111111111111 0.00280913674659921 0.482496514917337 0.111111111111111 0.00280913674659921 0.482496514917337 0.164731007342707 0.00371655949100211 1.22893284664147 0.0876274288278654 294 5574 False False 1.48257906608436 0.5076309304638 4.41701976519092 4.79892504079086e-05 1.21498188904634e-06 0.000267349661612127 0.99970875200233 0.999426206431739 0.999874251669172 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 1 7 8 7 13366 21306 0.000598175564528189 0.000258283997825234 0.00117830226263269 0.99967156195749 0.999323409938814 0.999867941002665 0.533333333333333 0.265861347277396 0.787333270480692 0.125 0.0031597235312519 0.526509670875206 0.125 0.0031597235312519 0.526509670875206 0.227720655821808 0.00505650350143479 1.77285525985572 0.163772252952032 230 4479 False False 0 0 0 0 0 0 0 1.82176524657446 0.577110136838304 5.90363815458136 7.48111019675319e-05 1.89405132098963e-06 0.000416749510461935 0.99967156195749 0.999323409938814 0.999867941002665 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Pro398Ala Rv1258c_p.Pro398Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 6 0 20840 27468 0.000287825002398541 0.000105633792978048 0.000626367784710498 1 0.999865711673152 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 3798 5574 False False Inf 1.55167078958407 Inf 0 0 0.000176993905465082 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 13370 21313 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 1 0.999826933785262 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3039 4479 False False 0 0 0 0 0 0 0 Inf 1.05210128917758 Inf 0 0 0.000275869155324334 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Pro414Ser Rv1258c_p.Pro414Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 42 171 20804 27297 0.00201477501678979 0.00145244658837854 0.00272242536509554 0.993774574049803 0.992772014983154 0.994670409165841 0.197183098591549 0.145963029103402 0.257039780844588 NA NA NA 0 0 0.0213413745665028 NA NA NA NA NA NA False True 0.322271020755117 0.224144877152528 0.454206701028416 0 0 0.000177300155018271 0.993774574049803 0.992772014983154 0.994670409165841 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 25 117 13349 21196 0.00186929863915059 0.00121006548869323 0.00275822519578355 0.994510392718059 0.993424437373028 0.995457892697964 0.176056338028169 0.117294342161303 0.248826841072558 NA NA NA 0 0 0.0310370316931115 NA NA NA NA NA NA False True 0 1 1 0 0 1 0 0.33928083220165 0.21087615558305 0.526320063480021 0 0 0.000276303079351708 0.994510392718059 0.993424437373028 0.995457892697964 23 Not assoc w R 5) Not assoc w R No change yes 1 +Isoniazid Rv1258c p.Pro54Leu Rv1258c_p.Pro54Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3823 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3060 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 1 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Pro54Ser Rv1258c_p.Pro54Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Pro8Arg Rv1258c_p.Pro8Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3803 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Pro8Leu Rv1258c_p.Pro8Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 7.01573328293188 0.509380354735251 864 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Pro90His Rv1258c_p.Pro90His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3834 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3070 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Pro90Leu Rv1258c_p.Pro90Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Pro90Ser Rv1258c_p.Pro90Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Ser126* Rv1258c_p.Ser126* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Ser184Pro Rv1258c_p.Ser184Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 0 0 0.841886116991581 0 0 0.521823750104981 0 0 7.01522242414976 0.509375458954636 835.5 5574 False False 0 0 1.43785249906968 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 8.48455543336434 0.526168130935474 674.5 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Ser244Arg Rv1258c_p.Ser244Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3830 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3066 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Ser292Leu Rv1258c_p.Ser292Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3844 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3080 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 4 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Ser40Asn Rv1258c_p.Ser40Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Ser417* Rv1258c_p.Ser417* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3805 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3044 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Ser4Thr Rv1258c_p.Ser4Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 6 20846 27462 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 0 0 0.4592581264399 0 0 0.841886116991581 0 0 0.4592581264399 0 0 7.01496699475827 0.509373011390968 833.5 5574 False False 0 0 1.11900921779861 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 6 13374 21307 0 0 0.000275786657608973 0.999718481677849 0.999387354605726 0.999896680954833 0 0 0.4592581264399 0 0 0.841886116991581 0 0 0.4592581264399 0 0 8.48375915535457 0.526157954830459 671 4479 False False 0 0 0 0 0 0 0 0 0 1.35335561005417 0 0 0.000275786657608973 0.999718481677849 0.999387354605726 0.999896680954833 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Ter420Glyext*? Rv1258c_p.Ter420Glyext*? 2 stop_lost (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3804 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3043 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Thr167Ala Rv1258c_p.Thr167Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3846 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3082 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Thr167Met Rv1258c_p.Thr167Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Thr167Pro Rv1258c_p.Thr167Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Thr16Met Rv1258c_p.Thr16Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3867 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3102 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Thr173fs Rv1258c_p.Thr173fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3799 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3040 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Thr173Ile Rv1258c_p.Thr173Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Thr173Pro Rv1258c_p.Thr173Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.18853708762714 0.264070532102877 442 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.85633740727807 0.289259828934126 294 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Thr179fs Rv1258c_p.Thr179fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3863 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3097 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Thr179Met Rv1258c_p.Thr179Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3815 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Thr202Ala Rv1258c_p.Thr202Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3774 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3017 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Thr234Ile Rv1258c_p.Thr234Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Thr290Ile Rv1258c_p.Thr290Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01632529799099 0.509386028876591 1135.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Thr297Ile Rv1258c_p.Thr297Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 3 2 20843 27466 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999927188000582 0.999737003036386 0.999991182007438 0.6 0.146632799634673 0.947255049473683 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01699856622015 0.509392482788101 1176.5 5574 False False 1.97663484143357 0.226402568392661 23.6672561646805 0 0 0.00017696843241753 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48598624162872 0.526186417038858 925 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 4 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Thr371Ile Rv1258c_p.Thr371Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3781 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3024 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Thr379Ala Rv1258c_p.Thr379Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3800 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3041 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Thr379Lys Rv1258c_p.Thr379Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Thr390Ser Rv1258c_p.Thr390Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Thr51Ala Rv1258c_p.Thr51Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Thr59Ala Rv1258c_p.Thr59Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Thr59Arg Rv1258c_p.Thr59Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Thr64Ser Rv1258c_p.Thr64Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 7 20846 27461 0 0 0.00017694296670111 0.999745158002038 0.999474999027776 0.999897534357495 0 0 0.409616397225003 0 0 0.521823750104981 0 0 0.409616397225003 0 0 1.4377474794477 0.0743318383647099 231 5574 False False 0 0 0.914121240039481 0 0 0.00017694296670111 0.999745158002038 0.999474999027776 0.999897534357495 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 6 13374 21307 0 0 0.000275786657608973 0.999718481677849 0.999387354605726 0.999896680954833 0 0 0.4592581264399 0 0 0.602364635616474 0 0 0.4592581264399 0 0 2.41397728077497 0.305476897383561 466 4479 False False 0 0 0 0 0 0 0 0 0 1.35335561005417 0 0 0.000275786657608973 0.999718481677849 0.999387354605726 0.999896680954833 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Trp175* Rv1258c_p.Trp175* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Trp220Cys Rv1258c_p.Trp220Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Trp220* Rv1258c_p.Trp220* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Trp262* Rv1258c_p.Trp262* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 3 2 20843 27466 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999927188000582 0.999737003036386 0.999991182007438 0.6 0.146632799634673 0.947255049473683 0 0 0.975 0 0 0.841886116991581 0 0 51.3539402930048 1 2027.5 5574 False False 1.97663484143357 0.226402568392661 23.6672561646805 0 0 0.00017696843241753 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Trp94* Rv1258c_p.Trp94* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3875 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3110 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Tyr146Cys Rv1258c_p.Tyr146Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Tyr250Cys Rv1258c_p.Tyr250Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Tyr250His Rv1258c_p.Tyr250His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Tyr325Cys Rv1258c_p.Tyr325Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Tyr332fs Rv1258c_p.Tyr332fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3869 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3104 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Tyr334Cys Rv1258c_p.Tyr334Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3795 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3036 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Tyr334His Rv1258c_p.Tyr334His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Val156Asp Rv1258c_p.Val156Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3855 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3090 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Val209Ala Rv1258c_p.Val209Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Val219Ala Rv1258c_p.Val219Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 16 0 16 2 39 20844 27429 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.998580166011358 0.998059546022616 0.998990170448098 0.048780487804878 0.00596311824104283 0.16533335341783 0 0 0.205907214207822 0 0 0.0902511009603342 0 0 0.341271934775288 0.000150279933113079 62 5574 True False 0.0674829871721063 0.00788067837328499 0.260696382099763 0 0 0.000176959943030976 0.998580166011358 0.998059546022616 0.998990170448098 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 15 0 15 1 35 13373 21278 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.998357809787453 0.997716843861875 0.998855896017746 0.0277777777777777 0.00070302520590478 0.145289264746853 0 0 0.218019360910534 0 0 0.100032435572105 0 0 0.44371534668778 0.000848042860609654 52 4479 False False 0 0 0 0 0 0 0 0.0454604693892811 0.00112365561826144 0.270550334589308 0 0 0.000275807277411719 0.998357809787453 0.997716843861875 0.998855896017746 3 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Val224Ala Rv1258c_p.Val224Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3831 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3067 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Val245Met Rv1258c_p.Val245Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 17 0 20829 27468 0.000815504173462534 0.000475130725961031 0.00130538114673077 1 0.999865711673152 1 1 0.804935677030906 1 NA NA NA NA NA NA NA NA NA NA 3847 5574 False False Inf 5.44096997305453 Inf 0 0 0.000177087369412526 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3083 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Val25Ile Rv1258c_p.Val25Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Val25Phe Rv1258c_p.Val25Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Val280Leu Rv1258c_p.Val280Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 12 62 20834 27406 0.000575650004797083 0.000297481006307132 0.00100532857413147 0.997742828018057 0.997107328463502 0.998269014702526 0.162162162162162 0.0866989639583081 0.266135808940776 0 0 0.975 0 0 0.0577626344292909 0 0 51.2639685742351 1 2027.5 5574 False False 0.254602433367293 0.124833951559111 0.477183634994998 0 0 0.000177044873566246 0.997742828018057 0.997107328463502 0.998269014702526 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 7 51 13367 21262 0.000523403618962165 0.000210460468745924 0.00107811225334149 0.997607094261718 0.996854956319785 0.998217821389018 0.120689655172413 0.0499266160234807 0.232983637707993 0 0 0.975 0 0 0.0697770307495386 0 0 61.9785202657434 1 1642.5 4479 False False 0 0 0 0 0 0 0 0.218322265690895 0.0835665347426641 0.483362952227894 0 0 0.000275931061008045 0.997607094261718 0.996854956319785 0.998217821389018 14 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Val285Ile Rv1258c_p.Val285Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 1 20843 27467 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999963594000291 0.999797175631493 0.999999078280314 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 51.3558084523276 1 2027.5 5574 False False 3.95341361608213 0.31739219148065 207.323829234655 0 0 0.00017696843241753 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 1 13371 21312 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999953080279641 0.999738608085756 0.999998812096234 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 62.1055547471297 1 1642.5 4479 False False 0 0 0 0 0 0 0 4.78169172088849 0.383875689805931 250.696170545132 0 0 0.000275848526268708 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Val304Ala Rv1258c_p.Val304Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Val320Ala Rv1258c_p.Val320Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3806 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3045 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Val335Leu Rv1258c_p.Val335Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3782 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3025 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Val335Met Rv1258c_p.Val335Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 51.3428199661809 1 2027.5 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 62.0858160113928 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Val348Leu Rv1258c_p.Val348Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.18853708762714 0.264070532102877 442 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.85633740727807 0.289259828934126 294 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Val349Ile Rv1258c_p.Val349Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3835 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3071 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Val388Met Rv1258c_p.Val388Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 18 0 18 0 18 20846 27450 0 0 0.00017694296670111 0.999344692005242 0.998964527817385 0.999611578174657 0 0 0.185301968137852 0 0 0.185301968137852 0 0 0.185301968137852 0 0 0.299528420581916 4.50340570613048e-05 57 5574 True False 0 0 0.299528420581916 0 0 0.00017694296670111 0.999344692005242 0.998964527817385 0.999611578174657 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 13 0 13 0 13 13374 21300 0 0 0.000275786657608973 0.99939004363534 0.998957181904114 0.999675185224884 0 0 0.24705263800047 0 0 0.24705263800047 0 0 0.24705263800047 0 0 0.522684266329562 0.00268949884736775 60 4479 False False 0 0 0 0 0 0 0 0 0 0.522684266329562 0 0 0.000275786657608973 0.99939004363534 0.998957181904114 0.999675185224884 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Val47Ala Rv1258c_p.Val47Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3856 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Val66Ala Rv1258c_p.Val66Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3832 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3068 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv1258c p.Val66Ile Rv1258c_p.Val66Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.18853708762714 0.264070532102877 442 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.48495357236853 0.526173219289417 690 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid Rv1258c p.Val74Ala Rv1258c_p.Val74Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c c.1014G>T Rv2752c_c.1014G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1017G>A Rv2752c_c.1017G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1018C>T Rv2752c_c.1018C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1026C>G Rv2752c_c.1026C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1029C>G Rv2752c_c.1029C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1035G>A Rv2752c_c.1035G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.99604811372315 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.41420404242617 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1050A>C Rv2752c_c.1050A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1050A>T Rv2752c_c.1050A>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.105A>G Rv2752c_c.105A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1063C>T Rv2752c_c.1063C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 26 50 20820 27418 0.00124724167706034 0.000814896390023582 0.00182696777478964 0.998179700014562 0.997600856968635 0.998648645693372 0.342105263157894 0.237056796816215 0.459876026195355 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.684791546589817 0.409032472892 1.12168873545551 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 14 25 13360 21288 0.00104680723792433 0.000572413688832994 0.00175574154681136 0.998827006991038 0.998268914575298 0.99924076142744 0.358974358974359 0.212037185560799 0.528204886374588 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.892311377245509 0.428619387448716 1.78464756035964 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1068C>T Rv2752c_c.1068C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1074C>T Rv2752c_c.1074C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 6 5 20840 27463 0.000287825002398541 0.000105633792978048 0.000626367784710498 0.999817970001456 0.999575254267103 0.999940892797913 0.545454545454545 0.233793597659345 0.832511905936292 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.58136276391554 0.402037805145704 6.55169187240669 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 5 13373 21308 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999765401398207 0.999452610763328 0.999923822225278 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.318671950945935 0.00674139558547252 2.84834809554519 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.-10T>C Rv2752c_c.-10T>C 2 upstream_gene_variant 3066201 1 1 0 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 51.3533466119536 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 62.1009148060541 1 1642.5 4479 False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 0 0 0.000275827900298067 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c c.1104A>G Rv2752c_c.1104A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1105A>C Rv2752c_c.1105A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1107G>A Rv2752c_c.1107G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1119C>G Rv2752c_c.1119C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.111G>A Rv2752c_c.111G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1122C>G Rv2752c_c.1122C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1122C>T Rv2752c_c.1122C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1128G>C Rv2752c_c.1128G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1134C>T Rv2752c_c.1134C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 9 9 20837 27459 0.000431737503597812 0.000197436276106449 0.000819413341228355 0.999672346002621 0.99937810218515 0.999850165132458 0.5 0.260190582895097 0.739809417104903 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31780006718817 0.463377469353788 3.74736264198833 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 8 9 13366 21304 0.000598175564528189 0.000258283997825234 0.00117830226263269 0.999577722516773 0.999198537836033 0.999806890245066 0.470588235294117 0.22983268726599 0.721881699668893 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.41679551764842 0.475515021503607 4.1383714593658 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1137T>C Rv2752c_c.1137T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 8 5 20838 27463 0.000383766669864722 0.000165697303700768 0.000756032532322191 0.999817970001456 0.999575254267103 0.999940892797913 0.615384615384615 0.315777602914063 0.861420661109839 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.10868605432383 0.608141362834586 8.19335359905159 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 3 13371 21310 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999859240838924 0.999588697652472 0.999970971136275 0.5 0.118117248757025 0.881882751242974 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59374766285244 0.213424225946693 11.9045637110481 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1141C>T Rv2752c_c.1141C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1144C>T Rv2752c_c.1144C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1152C>G Rv2752c_c.1152C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1155C>T Rv2752c_c.1155C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1158C>T Rv2752c_c.1158C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1161G>A Rv2752c_c.1161G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1167G>A Rv2752c_c.1167G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 12 20843 27456 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999563128003495 0.99923699702714 0.999774242139628 0.2 0.0433120051058366 0.480891133806853 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.329319195893105 0.0596345841309398 1.2205321614887 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 6 13374 21307 0 0 0.000275786657608973 0.999718481677849 0.999387354605726 0.999896680954833 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.35335561005417 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1167G>T Rv2752c_c.1167G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1173C>T Rv2752c_c.1173C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.99604811372315 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.41420404242617 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.120G>A Rv2752c_c.120G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.18865318395302 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.85651838973546 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1212C>G Rv2752c_c.1212C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1221C>T Rv2752c_c.1221C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.99604811372315 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.41420404242617 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1225C>T Rv2752c_c.1225C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1239C>G Rv2752c_c.1239C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1239C>T Rv2752c_c.1239C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1242C>T Rv2752c_c.1242C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1248G>A Rv2752c_c.1248G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1251A>G Rv2752c_c.1251A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1269C>T Rv2752c_c.1269C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1275C>T Rv2752c_c.1275C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 4 20842 27464 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999854376001165 0.999627187086024 0.999960320981843 0.5 0.157012770487058 0.842987229512941 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31772382688801 0.245404796089043 7.07564826366186 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 4 13373 21309 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999812321118566 0.999519537882235 0.999948861529775 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.398358633066626 0.00809276091420046 4.02622197901862 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1278T>C Rv2752c_c.1278T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1281C>T Rv2752c_c.1281C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1287C>A Rv2752c_c.1287C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1287C>T Rv2752c_c.1287C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1290C>T Rv2752c_c.1290C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1311T>C Rv2752c_c.1311T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1314C>T Rv2752c_c.1314C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1317C>A Rv2752c_c.1317C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1317C>G Rv2752c_c.1317C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 13 12 20833 27456 0.000623620838530173 0.000332092285535748 0.00106617452923529 0.999563128003495 0.99923699702714 0.999774242139628 0.52 0.313057044457032 0.722031990330053 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.4277348437575 0.600460040187219 3.42441617062106 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 13 11 13361 21302 0.000972035292358307 0.000517666151348512 0.00166163634851859 0.999483883076056 0.999076712346733 0.999742329032819 0.541666666666666 0.328208075695178 0.744469798005253 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.88422205741268 0.778667289668932 4.64650711716965 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1320T>C Rv2752c_c.1320T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.135C>T Rv2752c_c.135C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.43785249906968 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.41420404242617 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1368C>T Rv2752c_c.1368C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1380C>T Rv2752c_c.1380C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1383C>A Rv2752c_c.1383C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1404G>A Rv2752c_c.1404G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1419C>A Rv2752c_c.1419C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1428C>T Rv2752c_c.1428C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1431C>T Rv2752c_c.1431C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1438A>C Rv2752c_c.1438A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1452C>T Rv2752c_c.1452C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1467G>A Rv2752c_c.1467G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1467G>T Rv2752c_c.1467G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.247471899512553 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1470A>G Rv2752c_c.1470A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.18865318395302 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1473T>C Rv2752c_c.1473T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 4 20844 27464 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999854376001165 0.999627187086024 0.999960320981843 0.333333333333333 0.0432718682927417 0.777221904496487 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.658798695068125 0.0595601499680727 4.59736120623929 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 3 13373 21310 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999859240838924 0.999588697652472 0.999970971136275 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.531169769934445 0.010122018243966 6.61631049307563 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1479C>T Rv2752c_c.1479C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1485G>A Rv2752c_c.1485G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1491C>T Rv2752c_c.1491C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1503C>T Rv2752c_c.1503C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 7 7 20839 27461 0.000335795836131632 0.000135017659185429 0.000691744589626827 0.999745158002038 0.999474999027776 0.999897534357495 0.5 0.230360541448062 0.769639458551937 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31776956667786 0.394379779927489 4.40379451357517 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 6 3 13368 21310 0.000448631673396141 0.000164657143425453 0.000976224581517196 0.999859240838924 0.999588697652472 0.999970971136275 0.666666666666666 0.29929505620854 0.925145368580308 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.188210652304 0.680764303219066 19.7036233222165 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1509G>A Rv2752c_c.1509G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1509G>T Rv2752c_c.1509G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.43785249906968 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.85651838973546 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1521C>T Rv2752c_c.1521C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1527C>T Rv2752c_c.1527C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1539A>C Rv2752c_c.1539A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1560C>T Rv2752c_c.1560C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 464 1877 20382 25591 0.0222584668521538 0.0202987106398125 0.0243529695724649 0.931665938546672 0.928617919940669 0.934622258524354 0.198205894916702 0.182229067674741 0.214941505623423 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.310380313528912 0.279332973935563 0.344361461954229 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 328 1438 13046 19875 0.0245251981456557 0.02197028475099 0.0272897500995358 0.932529442124524 0.929079045977513 0.935861289276672 0.18573046432616 0.167843544697023 0.204667792681979 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 0 0.347491928102059 0.306658692743083 0.39285223073547 NA NA NA NA NA NA 198 5) Not assoc w R Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1566C>T Rv2752c_c.1566C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.156C>T Rv2752c_c.156C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1572C>A Rv2752c_c.1572C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1596G>A Rv2752c_c.1596G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 8 20846 27460 0 0 0.00017694296670111 0.99970875200233 0.999426206431739 0.999874251669172 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.771808536885009 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 8 13374 21305 0 0 0.000275786657608973 0.999624642237132 0.999260530264256 0.999837933676441 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.93343997011793 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1599G>A Rv2752c_c.1599G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1602C>T Rv2752c_c.1602C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1608G>T Rv2752c_c.1608G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1614C>T Rv2752c_c.1614C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.99604811372315 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.41420404242617 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1623G>A Rv2752c_c.1623G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.162G>A Rv2752c_c.162G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1635T>C Rv2752c_c.1635T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1638C>T Rv2752c_c.1638C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.439194051331254 0.00837049629364692 5.4704842261679 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1656G>A Rv2752c_c.1656G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.658815063564403 0.011171855707321 12.6567401482543 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1662G>T Rv2752c_c.1662G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1671G>A Rv2752c_c.1671G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.1676A>G Rv2752c_c.1676A>G 2 stop_retained_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.-17C>G Rv2752c_c.-17C>G 2 upstream_gene_variant 3066208 1 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 5326 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4288 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c c.183G>A Rv2752c_c.183G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 8 10 20838 27458 0.000383766669864722 0.000165697303700768 0.000756032532322191 0.999635940002912 0.999330582956894 0.999825405716755 0.444444444444444 0.215301507387299 0.692428341001244 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.05415107016028 0.361459566117819 2.96715150072479 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 8 8 13366 21305 0.000598175564528189 0.000258283997825234 0.00117830226263269 0.999624642237132 0.999260530264256 0.999837933676441 0.5 0.246510111490575 0.753489888509424 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59396977405356 0.521336794547919 4.87322276661434 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.201C>T Rv2752c_c.201C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.207C>T Rv2752c_c.207C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.210G>C Rv2752c_c.210G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.222C>T Rv2752c_c.222C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.229C>T Rv2752c_c.229C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.231G>C Rv2752c_c.231G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.234G>A Rv2752c_c.234G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 22 0 20824 27468 0.00105535834212798 0.000661501919043129 0.00159739179996395 1 0.999865711673152 1 1 0.845627487184425 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 7.22504284128202 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 20 0 13354 21313 0.00149543891132047 0.000913684725149316 0.00230864386780147 1 0.999826933785262 1 1 0.831566529016914 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 7.87776979048218 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.240C>T Rv2752c_c.240C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.99604811372315 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.85651838973546 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.243C>T Rv2752c_c.243C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.249C>T Rv2752c_c.249C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.24A>G Rv2752c_c.24A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.264G>C Rv2752c_c.264G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.-26A>G Rv2752c_c.-26A>G 2 upstream_gene_variant 3066217 NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5187 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c c.282C>G Rv2752c_c.282C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.-29C>T Rv2752c_c.-29C>T 2 upstream_gene_variant 3066220 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c c.306C>G Rv2752c_c.306C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.30C>T Rv2752c_c.30C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.-30T>C Rv2752c_c.-30T>C 2 upstream_gene_variant 3066221 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5560 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c c.312C>T Rv2752c_c.312C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.658815063564403 0.011171855707321 12.6567401482543 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.-31A>G Rv2752c_c.-31A>G 2 upstream_gene_variant 3066222 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c c.325T>C Rv2752c_c.325T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.330T>G Rv2752c_c.330T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.333G>C Rv2752c_c.333G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.339A>G Rv2752c_c.339A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.-34G>C Rv2752c_c.-34G>C 2 upstream_gene_variant 3066225 NA 0 0 0 19 0 20827 27468 0.000911445840928715 0.000548836318218138 0.00142297127227785 1 0.999865711673152 1 1 0.823533088193034 1 NA NA NA NA NA NA NA NA NA NA 5548 5574 False False Inf 6.15281557358538 Inf 0 0 0.000177104373463711 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 19 0 13355 21313 0.00142066696575444 0.000855544226513897 0.00221766232087821 1 0.999826933785262 1 1 0.823533088193034 1 NA NA NA NA NA NA NA NA NA NA 4459 4479 False False 0 0 0 0 0 0 0 Inf 7.44595921579462 Inf 0 0 0.000276178961828104 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c c.360C>T Rv2752c_c.360C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 16 20846 27452 0 0 0.00017694296670111 0.99941750400466 0.999054234895718 0.999667017718464 0 0 0.205907214207822 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.341525270527104 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 15 13374 21298 0 0 0.000275786657608973 0.999296204194623 0.998839461100611 0.999606039023746 0 0 0.218019360910534 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.444098942662297 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.366A>C Rv2752c_c.366A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.99604811372315 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.41420404242617 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.-36C>T Rv2752c_c.-36C>T 2 upstream_gene_variant 3066227 1 8 0 8 0 8 20846 27460 0 0 0.00017694296670111 0.99970875200233 0.999426206431739 0.999874251669172 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.771808536885009 0.0121106507453556 124 5574 False False 0 0 0.771808536885009 0 0 0.00017694296670111 0.99970875200233 0.999426206431739 0.999874251669172 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 0 8 13374 21305 0 0 0.000275786657608973 0.999624642237132 0.999260530264256 0.999837933676441 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.93343997011793 0.0270142859619197 118.5 4479 False False 0 0 0 0 0 0 0 0 0 0.93343997011793 0 0 0.000275786657608973 0.999624642237132 0.999260530264256 0.999837933676441 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c c.378C>A Rv2752c_c.378C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.544526627735454 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.387C>G Rv2752c_c.387C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.387C>T Rv2752c_c.387C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.63548263289195 0.137183409715989 155.34952410964 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.-38T>G Rv2752c_c.-38T>G 2 upstream_gene_variant 3066229 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c c.-39_-32delCTTCGGTG Rv2752c_c.-39_-32delCTTCGGTG 2 upstream_gene_variant 3066222 1 2 1 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.31767810026385 0.0167927522337569 103.35711725526 1 1253.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c c.39C>A Rv2752c_c.39C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.-3G>T Rv2752c_c.-3G>T 2 upstream_gene_variant 3066194 NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5376 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4322 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c c.438C>T Rv2752c_c.438C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.450T>G Rv2752c_c.450T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.45G>T Rv2752c_c.45G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.-46C>T Rv2752c_c.-46C>T 2 upstream_gene_variant 3066237 1 0 0 0 11 2 20835 27466 0.000527679171063993 0.000263444034397523 0.000943967185544106 0.999927188000582 0.999737003036386 0.999991182007438 0.846153846153846 0.545528944323442 0.980793328017471 NA NA NA 0 0 0.841886116991581 NA NA NA NA 5171 5574 False False 7.25044396448284 1.58206940172597 67.4160671725854 0 0 0.000177036376844338 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 11 2 13363 21311 0.000822491401226259 0.000410653977896139 0.00147118664271154 0.999906160559283 0.999661061221376 0.999988635406343 0.846153846153846 0.545528944323442 0.980793328017471 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4163 4479 False False 0 0 0 0 0 0 0 8.77127142108807 1.91382626509507 81.6341774283486 0 0 0.000276013645151466 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c c.477T>C Rv2752c_c.477T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 8 27 20838 27441 0.000383766669864722 0.000165697303700768 0.000756032532322191 0.999017038007863 0.998570161716172 0.99935212504807 0.228571428571428 0.104210431947815 0.401363256107314 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.390184598649902 0.153146412482617 0.883165633102372 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 23 13372 21290 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.998920846431755 0.998381177107211 0.999315790080537 0.08 0.00983959001879751 0.260305842105214 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.138446331724954 0.0158064786725931 0.560458722487371 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.-47C>T Rv2752c_c.-47C>T 2 upstream_gene_variant 3066238 1 0 0 0 11 2 20835 27466 0.000527679171063993 0.000263444034397523 0.000943967185544106 0.999927188000582 0.999737003036386 0.999991182007438 0.846153846153846 0.545528944323442 0.980793328017471 NA NA NA 0 0 0.841886116991581 NA NA NA NA 5434 5574 False False 7.25044396448284 1.58206940172597 67.4160671725854 0 0 0.000177036376844338 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 11 2 13363 21311 0.000822491401226259 0.000410653977896139 0.00147118664271154 0.999906160559283 0.999661061221376 0.999988635406343 0.846153846153846 0.545528944323442 0.980793328017471 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4366 4479 False False 0 0 0 0 0 0 0 8.77127142108807 1.91382626509507 81.6341774283486 0 0 0.000276013645151466 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c c.480C>G Rv2752c_c.480C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.658815063564403 0.011171855707321 12.6567401482543 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.480C>T Rv2752c_c.480C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.658815063564403 0.011171855707321 12.6567401482543 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.496C>T Rv2752c_c.496C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.498G>C Rv2752c_c.498G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.-50C>A Rv2752c_c.-50C>A 2 upstream_gene_variant 3066241 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c c.513C>T Rv2752c_c.513C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.528G>A Rv2752c_c.528G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.549C>T Rv2752c_c.549C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.439194051331254 0.00837049629364692 5.4704842261679 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.54C>T Rv2752c_c.54C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.553C>T Rv2752c_c.553C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.558G>T Rv2752c_c.558G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.561C>A Rv2752c_c.561C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.567G>A Rv2752c_c.567G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.576C>G Rv2752c_c.576C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.576C>T Rv2752c_c.576C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 34 30 20812 27438 0.00163100834692506 0.00112977696955073 0.00227843192161994 0.998907820008737 0.998441209231564 0.999262993209016 0.53125 0.402309844598351 0.657203471060379 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.49415721699019 0.887081562604367 2.52859304337921 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 20 28 13354 21285 0.00149543891132047 0.000913684725149316 0.00230864386780147 0.998686247829963 0.99810181776224 0.999126849229516 0.416666666666666 0.276127423864463 0.56786828865926 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.13850317721816 0.607768657555508 2.09554574894087 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.585C>T Rv2752c_c.585C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 4 20843 27464 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999854376001165 0.999627187086024 0.999960320981843 0.428571428571428 0.0989882784425078 0.815948432359917 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.988245454109293 0.144734627190883 5.84310835075667 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 4 13372 21309 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999812321118566 0.999519537882235 0.999948861529775 0.333333333333333 0.0432718682927417 0.777221904496487 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.796776847143284 0.0720475461928349 5.56077695166295 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.588G>A Rv2752c_c.588G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.594G>A Rv2752c_c.594G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.598C>T Rv2752c_c.598C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 1 20842 27467 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999963594000291 0.999797175631493 0.999999078280314 0.8 0.28358206388191 0.994949236620532 NA NA NA NA NA NA NA NA NA NA NA NA False False 5.27147106803569 0.521589398427432 259.279173455301 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.-5C>G Rv2752c_c.-5C>G 2 upstream_gene_variant 3066196 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c c.603C>T Rv2752c_c.603C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 2 20844 27466 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999927188000582 0.999737003036386 0.999991182007438 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.3176933410094 0.0955278435529395 18.1762534351792 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.606C>T Rv2752c_c.606C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.612G>A Rv2752c_c.612G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.633C>A Rv2752c_c.633C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.639A>G Rv2752c_c.639A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.18865318395302 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.85651838973546 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.651A>G Rv2752c_c.651A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.654G>A Rv2752c_c.654G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.66C>T Rv2752c_c.66C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.675C>T Rv2752c_c.675C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 148 46 20698 27422 0.00709968339249736 0.00600511515308256 0.00833488767208034 0.998325324013397 0.997766841513316 0.998773673863725 0.762886597938144 0.696685952597372 0.820869052358244 NA NA NA NA NA NA NA NA NA NA NA NA False False 4.2626004612922 3.04134598860941 6.07361705214467 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 41 34 13333 21279 0.00306564976820696 0.00220083411622644 0.00415662587679321 0.998404729507812 0.997771476125476 0.998894983644582 0.546666666666666 0.427478909222084 0.662055721095341 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.92454590776534 1.19096200064301 3.12828234995641 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.684T>C Rv2752c_c.684T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.684T>G Rv2752c_c.684T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.18865318395302 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.85651838973546 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.690C>T Rv2752c_c.690C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.69C>T Rv2752c_c.69C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.708G>A Rv2752c_c.708G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.99604811372315 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.41420404242617 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.711T>C Rv2752c_c.711T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.717C>G Rv2752c_c.717C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.18865318395302 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.720C>T Rv2752c_c.720C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.732G>A Rv2752c_c.732G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.658815063564403 0.011171855707321 12.6567401482543 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.753C>T Rv2752c_c.753C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.756A>C Rv2752c_c.756A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.765G>A Rv2752c_c.765G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.771G>A Rv2752c_c.771G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.777G>A Rv2752c_c.777G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.786C>T Rv2752c_c.786C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.795G>T Rv2752c_c.795G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.801G>A Rv2752c_c.801G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01598871232251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.48535171137227 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.804C>T Rv2752c_c.804C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.807C>T Rv2752c_c.807C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.819A>G Rv2752c_c.819A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 7 20846 27461 0 0 0.00017694296670111 0.999745158002038 0.999474999027776 0.999897534357495 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.914121240039481 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.41420404242617 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.828G>C Rv2752c_c.828G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.840A>T Rv2752c_c.840A>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.843G>A Rv2752c_c.843G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.846T>G Rv2752c_c.846T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.858C>G Rv2752c_c.858C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.63548263289195 0.137183409715989 155.34952410964 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.858C>T Rv2752c_c.858C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.861C>T Rv2752c_c.861C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.870C>T Rv2752c_c.870C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.876C>A Rv2752c_c.876C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.87C>T Rv2752c_c.87C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.882G>A Rv2752c_c.882G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.891C>G Rv2752c_c.891C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.891C>T Rv2752c_c.891C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.3484236392164 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 62.0916370035077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.-8delG Rv2752c_c.-8delG 2 upstream_gene_variant 3066198 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c c.918C>A Rv2752c_c.918C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31767810026385 0.0167927522337569 103.35711725526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.-937_-936delAG Rv2752c_c.-937_-936delAG 2 upstream_gene_variant 3067126 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c c.-937A>T Rv2752c_c.-937A>T 2 upstream_gene_variant 3067128 NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 5307 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4275 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c c.942G>A Rv2752c_c.942G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.-944C>T Rv2752c_c.-944C>T 2 upstream_gene_variant 3067135 1 1 0 1 29 26 20817 27442 0.00139115417825961 0.000931869577538548 0.00199732323166199 0.999053444007572 0.998613381560132 0.999381587946625 0.527272727272727 0.388041457980487 0.663465669274971 0 0 0.975 0 0 0.132274604497754 0 0 51.3731370001409 1 2027.5 5574 False False 1.47035522003096 0.835626437345212 2.59975958897242 0 0 0.000177189442725384 0.999053444007572 0.998613381560132 0.999381587946625 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 23 24 13351 21289 0.00171975474801853 0.00109047959787275 0.00257936584619975 0.998873926711396 0.998324952535764 0.99927837451873 0.489361702127659 0.340756964834897 0.639355296615258 0 0 0.975 0 0 0.142473597722525 0 0 62.1314428210016 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.52812211320001 0.823832707910731 2.82808837730537 0 0 0.000276261694450225 0.998873926711396 0.998324952535764 0.99927837451873 3 3) Uncertain significance No change no 1 +Isoniazid Rv2752c c.-945A>G Rv2752c_c.-945A>G 2 upstream_gene_variant 3067136 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c c.-945delA Rv2752c_c.-945delA 2 upstream_gene_variant 3067135 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c c.-948G>A Rv2752c_c.-948G>A 2 upstream_gene_variant 3067139 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c c.-950A>G Rv2752c_c.-950A>G 2 upstream_gene_variant 3067141 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5492 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4411 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c c.-951C>T Rv2752c_c.-951C>T 2 upstream_gene_variant 3067142 NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5308 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4276 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c c.-951delC Rv2752c_c.-951delC 2 upstream_gene_variant 3067141 1 7 0 7 5 11 20841 27457 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.999599534003203 0.9992835689522 0.999800072407065 0.3125 0.110169954717117 0.586620636451358 0 0 0.409616397225003 0 0 0.284914152918154 0 0 0.914207354855798 0.0219793440558618 164 5574 False False 0.598841444530231 0.163088823654088 1.86994347550002 0 0 0.000176985413634466 0.999599534003203 0.9992835689522 0.999800072407065 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 3 7 13371 21306 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.99967156195749 0.999323409938814 0.999867941002665 0.3 0.0667395111777345 0.652452850059997 0 0 0.521823750104981 0 0 0.409616397225003 0 0 1.73917333683954 0.163960277182317 263 4479 False False 0 0 0 0 0 0 0 0.682906503413571 0.113956481543253 2.99204017959139 0 0 0.000275848526268708 0.99967156195749 0.999323409938814 0.999867941002665 6 3) Uncertain significance No change no 1 +Isoniazid Rv2752c c.-960A>G Rv2752c_c.-960A>G 2 upstream_gene_variant 3067151 1 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 5450 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c c.-961G>A Rv2752c_c.-961G>A 2 upstream_gene_variant 3067152 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5119 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4117 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c c.966G>A Rv2752c_c.966G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 16 1 20830 27467 0.000767533339729444 0.000438773245501675 0.00124612759964746 0.999963594000291 0.999797175631493 0.999999078280314 0.941176470588235 0.713110603332779 0.998511825608733 NA NA NA NA NA NA NA NA NA NA NA NA False False 21.0980316850696 3.27696052461101 881.196612561466 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 16 1 13358 21312 0.00119635112905637 0.00068396778211822 0.00194207416051199 0.999953080279641 0.999738608085756 0.999998812096234 0.941176470588235 0.713110603332779 0.998511825608733 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 25.5271747267555 3.96458724647361 1065.16280179495 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.-966G>T Rv2752c_c.-966G>T 2 upstream_gene_variant 3067157 1 25 0 25 0 27 20846 27441 0 0 0.00017694296670111 0.999017038007863 0.998570161716172 0.99935212504807 0 0 0.127702867615432 0 0 0.137185171530712 0 0 0.127702867615432 0 0 0.209352581010965 1.14801752420289e-06 34 5574 True False 0 0 0.192769550418274 0 0 0.00017694296670111 0.999017038007863 0.998570161716172 0.99935212504807 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 23 0 23 0 25 13374 21288 0 0 0.000275786657608973 0.998827006991038 0.998268914575298 0.99924076142744 0 0 0.137185171530712 0 0 0.148185128915224 0 0 0.137185171530712 0 0 0.276975071776885 1.59282950581648e-05 28 4479 True False 0 0 0 0 0 0 0 0 0 0.253145616016219 0 0 0.000275786657608973 0.998827006991038 0.998268914575298 0.99924076142744 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c c.-967G>A Rv2752c_c.-967G>A 2 upstream_gene_variant 3067158 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c c.978C>T Rv2752c_c.978C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0337859573643402 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Isoniazid Rv2752c c.-981A>G Rv2752c_c.-981A>G 2 upstream_gene_variant 3067172 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c deletion Rv2752c_deletion 2 feature_ablation (see "Genomic_coordinates" sheet) NA 0 0 0 3 1 20843 27467 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999963594000291 0.999797175631493 0.999999078280314 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 5435 5574 False False 3.95341361608213 0.31739219148065 207.323829234655 0 0 0.00017696843241753 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4367 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c LoF Rv2752c_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 72 0 72 405 128 20441 27340 0.0194281876619015 0.0175977840548098 0.0213942798917061 0.995340032037279 0.994461724903384 0.996110867887529 0.759849906191369 0.721262913542866 0.795527333157018 0 0 0.0499440837058546 0 0 0.0284080534435439 0 0 0.0703150977030861 5.97219014274591e-18 8 5574 True False 4.23195874712587 3.45775048144267 5.20871849388655 0 0 0.000180448442729167 0.995340032037279 0.994461724903384 0.996110867887529 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 64 0 64 251 105 13123 21208 0.0187677583370719 0.0165356418168056 0.0212125928278904 0.995073429362361 0.994039181815252 0.995968837724326 0.70505617977528 0.654711764981125 0.75195155896011 0 0 0.0560090893866365 0 0 0.0345222141265055 0 0 0.0959237026172364 7.59368161831874e-14 8 4479 True False 0 0 0 0 0 0 0 3.86323394403863 3.06084743142181 4.90416375783789 0 0 0.000281060811559881 0.995073429362361 0.994039181815252 0.995968837724326 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ala110fs Rv2752c_p.Ala110fs 2 frameshift (see "Genomic_coordinates" sheet) 1 4 0 4 2 5 20844 27463 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999817970001456 0.999575254267103 0.999940892797913 0.285714285714285 0.0366925661760855 0.709579136262657 0 0 0.602364635616474 0 0 0.521823750104981 0 0 1.99616680581723 0.139124074991616 347 5574 False False 0.527019765879869 0.0501829950712842 3.21985261870185 0 0 0.000176959943030976 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ala110Ser Rv2752c_p.Ala110Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5459 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4384 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ala113Glu Rv2752c_p.Ala113Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5149 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4142 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ala113Gly Rv2752c_p.Ala113Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5131 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4128 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ala153Val Rv2752c_p.Ala153Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 1.99597553667858 0.139114336996004 304.5 5574 False False 0 0 1.43785249906968 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 5 13374 21308 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 2.41409066157565 0.305475026346142 461 4479 False False 0 0 0 0 0 0 0 0 0 1.73894646374006 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ala155Thr Rv2752c_p.Ala155Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ala155Val Rv2752c_p.Ala155Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5297 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4267 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ala157_Thr160del Rv2752c_p.Ala157_Thr160del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ala206Thr Rv2752c_p.Ala206Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5309 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ala206Val Rv2752c_p.Ala206Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ala20Glu Rv2752c_p.Ala20Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01632529799099 0.509386028876591 1135.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ala20Pro Rv2752c_p.Ala20Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 1 4 20845 27464 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999854376001165 0.999627187086024 0.999960320981843 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 1.99614374716563 0.139122901336525 342.5 5574 False False 0.329383545214679 0.00669260119676484 3.32889360843958 0 0 0.000176951454458875 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 3 13373 21310 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999859240838924 0.999588697652472 0.999970971136275 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85680682534852 0.289279625558287 389.5 4479 False False 0 0 0 0 0 0 0 0.531169769934445 0.010122018243966 6.61631049307563 0 0 0.000275807277411719 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ala20Val Rv2752c_p.Ala20Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 5298 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4268 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ala229fs Rv2752c_p.Ala229fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5436 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4368 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ala236Val Rv2752c_p.Ala236Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5359 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ala239Val Rv2752c_p.Ala239Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 1 20843 27467 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999963594000291 0.999797175631493 0.999999078280314 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 51.3558084523276 1 2027.5 5574 False False 3.95341361608213 0.31739219148065 207.323829234655 0 0 0.00017696843241753 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4143 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ala251Val Rv2752c_p.Ala251Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ala252dup Rv2752c_p.Ala252dup 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ala252Glu Rv2752c_p.Ala252Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 5172 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4164 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ala252Thr Rv2752c_p.Ala252Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ala252Val Rv2752c_p.Ala252Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5282 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4253 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ala254dup Rv2752c_p.Ala254dup 2 inframe_insertion (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5507 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4424 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 2 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ala254Val Rv2752c_p.Ala254Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.43785249906968 0.0743380732312645 251 5574 False False 0 0 1.43785249906968 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 13374 21308 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.73894646374006 0.163960020972012 248.5 4479 False False 0 0 0 0 0 0 0 0 0 1.73894646374006 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ala273Thr Rv2752c_p.Ala273Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 2 7 20844 27461 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999745158002038 0.999474999027776 0.999897534357495 0.222222222222222 0.0281449734778982 0.600093573716312 0 0 0.4592581264399 0 0 0.409616397225003 0 0 1.11907584135889 0.0402148300153378 210 5574 False False 0.376415275379005 0.0381509889597215 1.97729867984898 0 0 0.000176959943030976 0.999745158002038 0.999474999027776 0.999897534357495 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 2 7 13372 21306 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.99967156195749 0.999323409938814 0.999867941002665 0.222222222222222 0.0281449734778982 0.600093573716312 0 0 0.4592581264399 0 0 0.409616397225003 0 0 1.35349447126629 0.0884843124151618 180 4479 False False 0 0 0 0 0 0 0 0.455236955685654 0.0461387128464925 2.39147917078199 0 0 0.000275827900298067 0.99967156195749 0.999323409938814 0.999867941002665 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ala273Val Rv2752c_p.Ala273Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 108 20846 27360 0 0 0.00017694296670111 0.996068152031454 0.995254859326886 0.996773546954278 0 0 0.0335795502186544 NA NA NA 0 0 0.0335795502186544 NA NA NA NA NA NA False True 0 0 0.0456111898159121 0 0 0.00017694296670111 0.996068152031454 0.995254859326886 0.996773546954278 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 108 13374 21205 0 0 0.000275786657608973 0.994932670201285 0.993885227291265 0.99584137341058 0 0 0.0335795502186544 NA NA NA 0 0 0.0335795502186544 NA NA NA NA NA NA False True 1 1 1 0 0 1 0 0 0 0.0551237977293556 0 0 0.000275786657608973 0.994932670201285 0.993885227291265 0.99584137341058 NA Not assoc w R 5) Not assoc w R No change yes 1 +Isoniazid Rv2752c p.Ala282Gly Rv2752c_p.Ala282Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ala290fs Rv2752c_p.Ala290fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5549 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4460 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ala290Pro Rv2752c_p.Ala290Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5390 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4334 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ala292Asp Rv2752c_p.Ala292Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ala292del Rv2752c_p.Ala292del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ala292Val Rv2752c_p.Ala292Val 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5132 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4129 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ala296Val Rv2752c_p.Ala296Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 21 135 20825 27333 0.00100738750839489 0.000623693493785757 0.00153948878572471 0.995085190039318 0.994185354882549 0.995877688741245 0.134615384615384 0.0852995621947257 0.19838591354613 NA NA NA 0 0 0.0269550815831828 NA NA NA NA NA NA False True 0.20416806722689 0.122364261316446 0.324969101160504 0 0 0.000177121380780691 0.995085190039318 0.994185354882549 0.995877688741245 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 14 101 13360 21212 0.00104680723792433 0.000572413688832994 0.00175574154681136 0.995261108243794 0.994244753944991 0.996138486579207 0.121739130434782 0.068181117311095 0.19581621835818 NA NA NA 0 0 0.0358646203900037 NA NA NA NA NA NA False True 0 0 0 0 0 1 0 0.220080630817572 0.11612231892712 0.386824616717777 0 0 0.000276075615707154 0.995261108243794 0.994244753944991 0.996138486579207 21 Not assoc w R Previous WHO guidance 4) Not assoc w R - Interim DOWN from NotAwR to NotAwRI yes Prev. WHO 3 +Isoniazid Rv2752c p.Ala330fs Rv2752c_p.Ala330fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 7 0 20839 27468 0.000335795836131632 0.000135017659185429 0.000691744589626827 1 0.999865711673152 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 5360 5574 False False Inf 1.89951899263229 Inf 0 0 0.00017700239811062 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4312 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ala347Thr Rv2752c_p.Ala347Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ala354Ser Rv2752c_p.Ala354Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5188 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4178 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ala368fs Rv2752c_p.Ala368fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5404 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ala376Glu Rv2752c_p.Ala376Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5460 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4385 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ala376Gly Rv2752c_p.Ala376Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 3 8 20843 27460 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.99970875200233 0.999426206431739 0.999874251669172 0.272727272727272 0.0602177341729066 0.609742559572421 0 0 0.409616397225003 0 0 0.369416647552819 0 0 0.914219491978912 0.0219799673734291 166 5574 False False 0.494050760447152 0.0844081742669313 2.05877344876832 0 0 0.00017696843241753 0.99970875200233 0.999426206431739 0.999874251669172 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 1 6 13373 21307 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999718481677849 0.999387354605726 0.999896680954833 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.35345678111722 0.0884835334370246 175 4479 False False 0 0 0 0 0 0 0 0.265547496198808 0.00577686092206708 2.18912593855065 0 0 0.000275807277411719 0.999718481677849 0.999387354605726 0.999896680954833 4 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ala376Val Rv2752c_p.Ala376Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5213 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4198 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ala378Thr Rv2752c_p.Ala378Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ala378Val Rv2752c_p.Ala378Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 10 2 20836 27466 0.000479708337330902 0.000230061997553563 0.000882023176671562 0.999927188000582 0.999737003036386 0.999991182007438 0.833333333333333 0.515862251314033 0.979137474539907 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01935602287831 0.509415093143708 1209 5574 False False 6.59099635246688 1.40433109003891 61.9123962243262 0 0 0.000177027880937939 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 4 2 13370 21311 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 0.999906160559283 0.999661061221376 0.999988635406343 0.666666666666666 0.222778095503512 0.956728131707258 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48789040192002 0.526210754961348 965.5 4479 False False 0 0 0 0 0 0 0 3.18788332086761 0.456775580099959 35.246992707007 0 0 0.000275869155324334 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ala405fs Rv2752c_p.Ala405fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5133 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4130 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ala411Val Rv2752c_p.Ala411Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 51.3533466119536 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ala423fs Rv2752c_p.Ala423fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ala433Ser Rv2752c_p.Ala433Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5249 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4226 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ala436Asp Rv2752c_p.Ala436Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ala436Thr Rv2752c_p.Ala436Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 5283 5574 False False 0.439194051331254 0.00837049629364692 5.4704842261679 0 0 0.000176951454458875 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 3 13373 21310 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999859240838924 0.999588697652472 0.999970971136275 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4254 4479 False False 0 0 0 0 0 0 0 0.531169769934445 0.010122018243966 6.61631049307563 0 0 0.000275807277411719 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ala441Ser Rv2752c_p.Ala441Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 6 20846 27462 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 0 0 0.4592581264399 0 0 0.707598226178713 0 0 0.4592581264399 0 0 3.18830489497988 0.264063188431954 429 5574 False False 0 0 1.11900921779861 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 5 13374 21308 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 0 0 0.521823750104981 0 0 0.841886116991581 0 0 0.521823750104981 0 0 8.48415729435969 0.526163042782468 672 4479 False False 0 0 0 0 0 0 0 0 0 1.73894646374006 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ala454fs Rv2752c_p.Ala454fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5520 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4437 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ala474Thr Rv2752c_p.Ala474Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5521 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ala474Val Rv2752c_p.Ala474Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 6 1 20840 27467 0.000287825002398541 0.000105633792978048 0.000626367784710498 0.999963594000291 0.999797175631493 0.999999078280314 0.857142857142857 0.421276802956804 0.996389703138099 0 0 0.975 0 0 0.975 0 0 51.3631953898783 1 2027.5 5574 False False 7.90796545105566 0.959277004805377 363.132004070954 0 0 0.000176993905465082 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ala489Val Rv2752c_p.Ala489Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5531 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4446 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ala503Gly Rv2752c_p.Ala503Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5269 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4244 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ala520Ser Rv2752c_p.Ala520Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5173 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4165 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ala521Pro Rv2752c_p.Ala521Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ala521Ser Rv2752c_p.Ala521Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.43785249906968 0.0743380732312645 251 5574 False False 0 0 1.43785249906968 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 13374 21308 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.73894646374006 0.163960020972012 248.5 4479 False False 0 0 0 0 0 0 0 0 0 1.73894646374006 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ala521Thr Rv2752c_p.Ala521Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5250 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ala530fs Rv2752c_p.Ala530fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5134 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ala530Thr Rv2752c_p.Ala530Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 7.01573328293188 0.509380354735251 864 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4144 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ala530Val Rv2752c_p.Ala530Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5493 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4412 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ala89Glu Rv2752c_p.Ala89Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 5522 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4438 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Arg120fs Rv2752c_p.Arg120fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5550 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4461 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Arg120His Rv2752c_p.Arg120His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5251 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4227 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Arg17Gly Rv2752c_p.Arg17Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5508 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4425 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Arg17Pro Rv2752c_p.Arg17Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5225 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Arg17Trp Rv2752c_p.Arg17Trp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5150 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Arg224Leu Rv2752c_p.Arg224Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Arg227Gln Rv2752c_p.Arg227Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Arg227Gly Rv2752c_p.Arg227Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 3 2 20843 27466 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999927188000582 0.999737003036386 0.999991182007438 0.6 0.146632799634673 0.947255049473683 NA NA NA 0 0 0.841886116991581 NA NA NA NA 5461 5574 False False 1.97663484143357 0.226402568392661 23.6672561646805 0 0 0.00017696843241753 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 3 1 13371 21312 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999953080279641 0.999738608085756 0.999998812096234 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 4386 4479 False False 0 0 0 0 0 0 0 4.78169172088849 0.383875689805931 250.696170545132 0 0 0.000275848526268708 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Arg227Trp Rv2752c_p.Arg227Trp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5174 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4166 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Arg232Gln Rv2752c_p.Arg232Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5361 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Arg244Gln Rv2752c_p.Arg244Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Arg244His Rv2752c_p.Arg244His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5391 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4335 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Arg244Trp Rv2752c_p.Arg244Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 7.01573328293188 0.509380354735251 864 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.48495357236853 0.526173219289417 690 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Arg257Trp Rv2752c_p.Arg257Trp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5494 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Arg258Gln Rv2752c_p.Arg258Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5226 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4209 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Arg258Leu Rv2752c_p.Arg258Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 12 1 11 6 15 20840 27453 0.000287825002398541 0.000105633792978048 0.000626367784710498 0.999453910004368 0.999099467294252 0.999694326386446 0.285714285714285 0.11280940392194 0.521751118247113 0.0833333333333333 0.00210759323186022 0.384796165150944 0.0625 0.00158111172276588 0.302320738434531 0.119756586983074 0.00278638387341194 0.824099073110378 0.0169854702017132 147 5574 False False 0.526928982725527 0.167454720766552 1.43747246562868 4.79823424979607e-05 1.21480699612118e-06 0.000267311181643879 0.999453910004368 0.999099467294252 0.999694326386446 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 3 7 13371 21306 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.99967156195749 0.999323409938814 0.999867941002665 0.3 0.0667395111777345 0.652452850059997 0 0 0.4592581264399 0 0 0.409616397225003 0 0 1.35359566790166 0.0884864085358222 183 4479 False False 0 0 0 0 0 0 0 0.682906503413571 0.113956481543253 2.99204017959139 0 0 0.000275848526268708 0.99967156195749 0.999323409938814 0.999867941002665 4 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Arg258* Rv2752c_p.Arg258* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5495 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4413 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Arg264Leu Rv2752c_p.Arg264Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5343 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Arg264* Rv2752c_p.Arg264* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5310 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Arg268Cys Rv2752c_p.Arg268Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Arg268His Rv2752c_p.Arg268His 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 7.01573328293188 0.509380354735251 864 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.48495357236853 0.526173219289417 690 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Arg271Cys Rv2752c_p.Arg271Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Arg280* Rv2752c_p.Arg280* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5239 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Arg29Cys Rv2752c_p.Arg29Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 5551 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4462 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Arg29Gly Rv2752c_p.Arg29Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Arg317Pro Rv2752c_p.Arg317Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5195 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4185 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Arg320_Gly321insMetSerArg Rv2752c_p.Arg320_Gly321insMetSerArg 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 0 0 0 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 5344 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4301 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Arg320His Rv2752c_p.Arg320His 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Arg320Leu Rv2752c_p.Arg320Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01632529799099 0.509386028876591 1135.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Arg320Pro Rv2752c_p.Arg320Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Arg361Gly Rv2752c_p.Arg361Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 17 4 20829 27464 0.000815504173462534 0.000475130725961031 0.00130538114673077 0.999854376001165 0.999627187086024 0.999960320981843 0.809523809523809 0.580933958816472 0.945536431821593 NA NA NA 0 0 0.602364635616474 NA NA NA NA 5175 5574 False False 5.60382159489173 1.82741954871531 22.8935670955 0 0 0.000177087369412526 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 17 4 13357 21309 0.0012711230746224 0.000740644897312986 0.00203441363276193 0.999812321118566 0.999519537882235 0.999948861529775 0.809523809523809 0.580933958816472 0.945536431821593 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4167 4479 False False 0 0 0 0 0 0 0 6.78020887923935 2.2107049444884 27.7023273354881 0 0 0.000276137614096336 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Arg361Ser Rv2752c_p.Arg361Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5252 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4228 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Arg369fs Rv2752c_p.Arg369fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5135 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4131 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Arg389Gly Rv2752c_p.Arg389Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Arg389Trp Rv2752c_p.Arg389Trp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5311 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Arg391fs Rv2752c_p.Arg391fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 5 0 20841 27468 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 1 0.999865711673152 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 5196 5574 False False Inf 1.20760984683633 Inf 0 0 0.000176985413634466 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Arg391Ser Rv2752c_p.Arg391Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5227 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Arg39fs Rv2752c_p.Arg39fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5509 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4426 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Arg39* Rv2752c_p.Arg39* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 5 0 20841 27468 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 1 0.999865711673152 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 5259 5574 False False Inf 1.20760984683633 Inf 0 0 0.000176985413634466 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4234 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Arg401Gly Rv2752c_p.Arg401Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Arg404Ser Rv2752c_p.Arg404Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Arg465Leu Rv2752c_p.Arg465Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Arg465Trp Rv2752c_p.Arg465Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 9 4 20837 27464 0.000431737503597812 0.000197436276106449 0.000819413341228355 0.999854376001165 0.999627187086024 0.999960320981843 0.692307692307692 0.385738338249294 0.909079605427903 NA NA NA 0 0 0.602364635616474 NA NA NA NA 5478 5574 False False 2.96559005615011 0.827533510717841 13.1780977796214 0 0 0.000177019385846931 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 7 2 13367 21311 0.000523403618962165 0.000210460468745924 0.00107811225334149 0.999906160559283 0.999661061221376 0.999988635406343 0.777777777777777 0.399906426283687 0.971855026522101 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4399 4479 False False 0 0 0 0 0 0 0 5.58004787910525 1.06221404733015 55.0152654432543 0 0 0.000275931061008045 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Arg481His Rv2752c_p.Arg481His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5496 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4414 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Arg495dup Rv2752c_p.Arg495dup 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5510 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Arg528Gln Rv2752c_p.Arg528Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5451 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Arg534fs Rv2752c_p.Arg534fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5511 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4427 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Arg535Cys Rv2752c_p.Arg535Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 20 0 20826 27468 0.000959416674661805 0.000586132014909014 0.00148135424594851 1 0.999865711673152 1 1 0.831566529016914 1 NA NA NA NA NA NA NA NA NA NA 5327 5574 False False Inf 6.51017121398754 Inf 0 0 0.000177112876713918 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 14 0 13360 21313 0.00104680723792433 0.000572413688832994 0.00175574154681136 1 0.999826933785262 1 1 0.768364238349883 1 NA NA NA NA NA NA NA NA NA NA 4289 4479 False False 0 0 0 0 0 0 0 Inf 5.29062751649696 Inf 0 0 0.000276075615707154 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Arg547Cys Rv2752c_p.Arg547Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5532 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Arg547fs Rv2752c_p.Arg547fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5214 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4199 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Arg547Gly Rv2752c_p.Arg547Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5151 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Arg547His Rv2752c_p.Arg547His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5260 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4235 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Arg65His Rv2752c_p.Arg65His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Arg65Ser Rv2752c_p.Arg65Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Arg97fs Rv2752c_p.Arg97fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 7 1 20839 27467 0.000335795836131632 0.000135017659185429 0.000691744589626827 0.999963594000291 0.999797175631493 0.999999078280314 0.875 0.473490329124793 0.996840276468748 0 0 0.975 0 0 0.975 0 0 51.3656581746512 1 2027.5 5574 False False 9.22640241854215 1.18513781610454 415.029346412368 0 0 0.00017700239811062 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 1 13371 21312 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999953080279641 0.999738608085756 0.999998812096234 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 62.1055547471297 1 1642.5 4479 False False 0 0 0 0 0 0 0 4.78169172088849 0.383875689805931 250.696170545132 0 0 0.000275848526268708 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Arg97Gln Rv2752c_p.Arg97Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Arg97* Rv2752c_p.Arg97* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 5 1 20841 27467 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.999963594000291 0.999797175631493 0.999999078280314 0.833333333333333 0.358765421002325 0.99578925548551 0 0 0.975 0 0 0.975 0 0 51.360732841256 1 2027.5 5574 False False 6.58965500695744 0.737267067818355 311.215258952954 0 0 0.000176985413634466 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Asn269Asp Rv2752c_p.Asn269Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5152 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4145 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Asn30Asp Rv2752c_p.Asn30Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 5153 5574 False False Inf 0.869878292971449 Inf 0 0 0.000176976922618654 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 13370 21313 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 1 0.999826933785262 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 4146 4479 False False 0 0 0 0 0 0 0 Inf 1.05210128917758 Inf 0 0 0.000275869155324334 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Asn30His Rv2752c_p.Asn30His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 5452 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4377 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Asn30Lys Rv2752c_p.Asn30Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 13 1 20833 27467 0.000623620838530173 0.000332092285535748 0.00106617452923529 0.999963594000291 0.999797175631493 0.999999078280314 0.928571428571428 0.661315510068178 0.998193219340874 NA NA NA 0 0 0.975 NA NA NA NA 5345 5574 False False 17.1396822349157 2.57388324724397 725.995291467278 0 0 0.00017705337110378 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 12 0 13362 21313 0.000897263346792283 0.000463712283458933 0.00156681338714949 1 0.999826933785262 1 1 0.735351530602948 1 NA NA NA NA NA NA NA NA NA NA 4302 4479 False False 0 0 0 0 0 0 0 Inf 4.43112457890131 Inf 0 0 0.000276034298911909 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Asn30Ser Rv2752c_p.Asn30Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 12 4 8 9 11 20837 27457 0.000431737503597812 0.000197436276106449 0.000819413341228355 0.999599534003203 0.9992835689522 0.999800072407065 0.45 0.230577896775924 0.684721866959451 0.333333333333333 0.0992460911495833 0.651124493581186 0.266666666666666 0.0778715462910436 0.551003241036971 0.6588520420406 0.145163724980488 2.45983174201123 0.57126489046636 1218 5574 False False 1.07812152333916 0.394796214036334 2.86252654962574 0.000191929369991843 5.22966902810668e-05 0.000491341833708728 0.999599534003203 0.9992835689522 0.999800072407065 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 4 5 9 8 13365 21305 0.000672947510094212 0.000307759154923187 0.00127707788784856 0.999624642237132 0.999260530264256 0.999837933676441 0.529411764705882 0.278118300331106 0.770167312734009 0.444444444444444 0.136995662265166 0.787991493221131 0.333333333333333 0.0992460911495833 0.651124493581186 1.27527123082678 0.253013482663693 5.92683506662676 0.740865431448979 1001 4479 False False 0 0 0 0 0 0 0 1.79335016835016 0.613968381665058 5.34281908532333 0.00029919964096043 8.15276566733007e-05 0.000765891101882231 0.999624642237132 0.999260530264256 0.999837933676441 2 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Asn30Tyr Rv2752c_p.Asn30Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5392 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Asn344fs Rv2752c_p.Asn344fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5393 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Asn386Asp Rv2752c_p.Asn386Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5189 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4179 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Asn392fs Rv2752c_p.Asn392fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5270 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Asn406Lys Rv2752c_p.Asn406Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5328 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Asn406Ser Rv2752c_p.Asn406Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 51.349017027227 1 2027.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Asn425Lys Rv2752c_p.Asn425Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5136 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4132 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Asn522Asp Rv2752c_p.Asn522Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Asn522fs Rv2752c_p.Asn522fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5346 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4303 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Asp152Ala Rv2752c_p.Asp152Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 4 2 20842 27466 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999927188000582 0.999737003036386 0.999991182007438 0.666666666666666 0.222778095503512 0.956728131707258 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01733524879011 0.509395710775307 1192 5574 False False 2.63563957393724 0.377684835565828 29.1411399702847 0 0 0.000176976922618654 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 62.1009148060541 1 1642.5 4479 False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 0 0 0.000275827900298067 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Asp152fs Rv2752c_p.Asp152fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5561 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Asp170_Gly195del Rv2752c_p.Asp170_Gly195del 2 inframe_deletion (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5437 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Asp170Asn Rv2752c_p.Asp170Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 10 0 10 7 13 20839 27455 0.000335795836131632 0.000135017659185429 0.000691744589626827 0.999526722003786 0.99919081619501 0.999747976101462 0.35 0.153909204784541 0.592188534532828 0 0 0.30849710781876 0 0 0.24705263800047 0 0 0.587858956636231 0.00669310130810447 114 5574 False False 0.709413193457533 0.23961343440919 1.91354495396141 0 0 0.00017700239811062 0.999526722003786 0.99919081619501 0.999747976101462 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 7 8 13367 21305 0.000523403618962165 0.000210460468745924 0.00107811225334149 0.999624642237132 0.999260530264256 0.999837933676441 0.466666666666666 0.212666729519307 0.734138652722603 0 0 0.4592581264399 0 0 0.369416647552819 0 0 1.35393708630906 0.0884934960424651 188 4479 False False 0 0 0 0 0 0 0 1.39461921149098 0.430375114744886 4.40232345408191 0 0 0.000275931061008045 0.999624642237132 0.999260530264256 0.999837933676441 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Asp170fs Rv2752c_p.Asp170fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 5552 5574 False False Inf 0.869878292971449 Inf 0 0 0.000176976922618654 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 13370 21313 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 1 0.999826933785262 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 4463 4479 False False 0 0 0 0 0 0 0 Inf 1.05210128917758 Inf 0 0 0.000275869155324334 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Asp170Gly Rv2752c_p.Asp170Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 5 0 20841 27468 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 1 0.999865711673152 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 5197 5574 False False Inf 1.20760984683633 Inf 0 0 0.000176985413634466 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4186 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Asp174_Gln175insHis Rv2752c_p.Asp174_Gln175insHis 2 inframe_insertion (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5462 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4387 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Asp174fs Rv2752c_p.Asp174fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5394 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4336 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Asp174Glu Rv2752c_p.Asp174Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Asp179fs Rv2752c_p.Asp179fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5362 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Asp184fs Rv2752c_p.Asp184fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5215 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4200 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Asp184Glu Rv2752c_p.Asp184Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 7.01573328293188 0.509380354735251 864 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.48495357236853 0.526173219289417 690 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Asp184Gly Rv2752c_p.Asp184Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Asp184His Rv2752c_p.Asp184His 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 1 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Asp193Asn Rv2752c_p.Asp193Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5533 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Asp202Ala Rv2752c_p.Asp202Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 1 4 3 4 20843 27464 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999854376001165 0.999627187086024 0.999960320981843 0.428571428571428 0.0989882784425078 0.815948432359917 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 0.329415151369764 0.00669324284562576 3.32921305274435 0.398253697502972 583 5574 False False 0.988245454109293 0.144734627190883 5.84310835075667 4.79754365764728e-05 1.21463215353938e-06 0.000267272712750976 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 3 13373 21310 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999859240838924 0.999588697652472 0.999970971136275 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85680682534852 0.289279625558287 389.5 4479 False False 0 0 0 0 0 0 0 0.531169769934445 0.010122018243966 6.61631049307563 0 0 0.000275807277411719 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Asp202Tyr Rv2752c_p.Asp202Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5271 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4245 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Asp230Gly Rv2752c_p.Asp230Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5363 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4313 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Asp230Tyr Rv2752c_p.Asp230Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5463 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Asp243fs Rv2752c_p.Asp243fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5240 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Asp250Glu Rv2752c_p.Asp250Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 5438 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4369 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Asp298fs Rv2752c_p.Asp298fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5553 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4464 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Asp332fs Rv2752c_p.Asp332fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5299 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4269 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Asp332Gly Rv2752c_p.Asp332Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 11 0 20835 27468 0.000527679171063993 0.000263444034397523 0.000943967185544106 1 0.999865711673152 1 1 0.715085847081845 1 NA NA NA NA NA NA NA NA NA NA 5329 5574 False False Inf 3.30816067473776 Inf 0 0 0.000177036376844338 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 6 0 13368 21313 0.000448631673396141 0.000164657143425453 0.000976224581517196 1 0.999826933785262 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 4290 4479 False False 0 0 0 0 0 0 0 Inf 1.87681913692541 Inf 0 0 0.00027591042269331 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Asp332Tyr Rv2752c_p.Asp332Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5312 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Asp430Ala Rv2752c_p.Asp430Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5176 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Asp44Ala Rv2752c_p.Asp44Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 5300 5574 False False Inf 0.869878292971449 Inf 0 0 0.000176976922618654 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Asp44Glu Rv2752c_p.Asp44Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5253 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4229 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Asp44Gly Rv2752c_p.Asp44Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5216 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4201 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Asp450Gly Rv2752c_p.Asp450Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 11 1 20835 27467 0.000527679171063993 0.000263444034397523 0.000943967185544106 0.999963594000291 0.999797175631493 0.999999078280314 0.916666666666666 0.615203834849055 0.997892406768139 NA NA NA 0 0 0.975 NA NA NA NA 5301 5574 False False 14.501415886729 2.10741512283775 622.42135891494 0 0 0.000177036376844338 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 3 1 13371 21312 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999953080279641 0.999738608085756 0.999998812096234 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 4270 4479 False False 0 0 0 0 0 0 0 4.78169172088849 0.383875689805931 250.696170545132 0 0 0.000275848526268708 0.999953080279641 0.999738608085756 0.999998812096234 4 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Asp4fs Rv2752c_p.Asp4fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5120 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4118 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Asp500fs Rv2752c_p.Asp500fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 5439 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4370 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Asp58Glu Rv2752c_p.Asp58Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5534 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4447 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Asp63Ala Rv2752c_p.Asp63Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5198 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Asp63Gly Rv2752c_p.Asp63Gly 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 2 20842 27466 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999927188000582 0.999737003036386 0.999991182007438 0.666666666666666 0.222778095503512 0.956728131707258 NA NA NA 0 0 0.841886116991581 NA NA NA NA 5535 5574 False False 2.63563957393724 0.377684835565828 29.1411399702847 0 0 0.000176976922618654 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 1 13371 21312 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999953080279641 0.999738608085756 0.999998812096234 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 4448 4479 False False 0 0 0 0 0 0 0 4.78169172088849 0.383875689805931 250.696170545132 0 0 0.000275848526268708 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Asp69Asn Rv2752c_p.Asp69Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5261 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4236 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Asp72fs Rv2752c_p.Asp72fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 5364 5574 False False Inf 0.869878292971449 Inf 0 0 0.000176976922618654 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 13370 21313 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 1 0.999826933785262 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 4314 4479 False False 0 0 0 0 0 0 0 Inf 1.05210128917758 Inf 0 0 0.000275869155324334 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Asp72Glu Rv2752c_p.Asp72Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5562 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Asp73Glu Rv2752c_p.Asp73Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5154 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4147 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Asp85Ala Rv2752c_p.Asp85Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 5228 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4210 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Asp85Asn Rv2752c_p.Asp85Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5523 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4439 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Asp85fs Rv2752c_p.Asp85fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5313 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Asp85Gly Rv2752c_p.Asp85Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 3 3 20843 27465 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999890782000873 0.99968085216583 0.999977476056514 0.5 0.118117248757025 0.881882751242974 0 0 0.841886116991581 0 0 0.707598226178713 0 0 7.01674310006514 0.509390033358317 1167.5 5574 False False 1.31770858321738 0.176469385678871 9.83712695959095 0 0 0.00017696843241753 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 3 3 13371 21310 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999859240838924 0.999588697652472 0.999970971136275 0.5 0.118117248757025 0.881882751242974 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.48685735854804 0.526197549940579 959 4479 False False 0 0 0 0 0 0 0 1.59374766285244 0.213424225946693 11.9045637110481 0 0 0.000275848526268708 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Asp99Asn Rv2752c_p.Asp99Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5563 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4468 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Cys116Phe Rv2752c_p.Cys116Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 20846 27462 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.11900921779861 0.0402109359097128 194.5 5574 False False 0 0 1.11900921779861 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 13374 21307 0 0 0.000275786657608973 0.999718481677849 0.999387354605726 0.999896680954833 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.35335561005417 0.0884814409570568 164 4479 False False 0 0 0 0 0 0 0 0 0 1.35335561005417 0 0 0.000275786657608973 0.999718481677849 0.999387354605726 0.999896680954833 1 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Cys141fs Rv2752c_p.Cys141fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5524 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4440 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Cys201Arg Rv2752c_p.Cys201Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 51.3533466119536 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 62.1009148060541 1 1642.5 4479 False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 0 0 0.000275827900298067 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Cys201fs Rv2752c_p.Cys201fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5554 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Cys201* Rv2752c_p.Cys201* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5564 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4469 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Cys201Tyr Rv2752c_p.Cys201Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5365 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4315 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Cys237Arg Rv2752c_p.Cys237Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5497 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Cys45* Rv2752c_p.Cys45* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5498 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4415 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Cys45Tyr Rv2752c_p.Cys45Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5512 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4428 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Gln132fs Rv2752c_p.Gln132fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Gln132Pro Rv2752c_p.Gln132Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 2 6 20844 27462 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999781564001747 0.999524617886493 0.999919833755107 0.25 0.0318540262499442 0.650855794412824 0 0 0.602364635616474 0 0 0.4592581264399 0 0 1.99609422188366 0.139120378841242 337.5 5574 False False 0.439167146421032 0.0433460282809438 2.45619176778693 0 0 0.000176959943030976 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Gln132* Rv2752c_p.Gln132* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Gln175His Rv2752c_p.Gln175His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5177 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4168 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Gln175* Rv2752c_p.Gln175* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5377 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4323 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Gln246Arg Rv2752c_p.Gln246Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5525 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4441 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Gln246Pro Rv2752c_p.Gln246Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 5416 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4353 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Gln246* Rv2752c_p.Gln246* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 10 0 20836 27468 0.000479708337330902 0.000230061997553563 0.000882023176671562 1 0.999865711673152 1 1 0.691502892181239 1 NA NA NA NA NA NA NA NA NA NA 5314 5574 False False Inf 2.95450432812812 Inf 0 0 0.000177027880937939 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 7 0 13367 21313 0.000523403618962165 0.000210460468745924 0.00107811225334149 1 0.999826933785262 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 4277 4479 False False 0 0 0 0 0 0 0 Inf 2.29755378883993 Inf 0 0 0.000275931061008045 1 0.999826933785262 1 1 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Gln247* Rv2752c_p.Gln247* 2 stop_gained (see "Genomic_coordinates" sheet) 1 10 0 10 78 16 20768 27452 0.00374172503118104 0.00295876822164733 0.00466767380859357 0.99941750400466 0.999054234895718 0.999667017718464 0.829787234042553 0.738352657586989 0.899461670748762 0 0 0.30849710781876 0 0 0.205907214207822 0 0 0.589805026683969 0.00669433137339398 118 5574 False False 6.44397630970724 3.72866351390776 11.8285726341949 0 0 0.000177607466205201 0.99941750400466 0.999054234895718 0.999667017718464 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 33 14 13341 21299 0.00246747420367878 0.00169908577453598 0.00346352196626117 0.999343123914981 0.998898118907794 0.999640834680135 0.702127659574468 0.551064312793674 0.826611497292222 0 0 0.30849710781876 0 0 0.231635761650116 0 0 0.712389872412647 0.00894448291938541 84 4479 False False 0 0 0 0 0 0 0 3.76319509139387 1.95873425395662 7.61405026862439 0 0 0.000276468743023847 0.999343123914981 0.998898118907794 0.999640834680135 4 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Gln275Arg Rv2752c_p.Gln275Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Gln275* Rv2752c_p.Gln275* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Gln299Arg Rv2752c_p.Gln299Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Gln308Glu Rv2752c_p.Gln308Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Gln308His Rv2752c_p.Gln308His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 5155 5574 False False Inf 0.869878292971449 Inf 0 0 0.000176976922618654 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4148 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Gln308Pro Rv2752c_p.Gln308Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 1 20843 27467 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999963594000291 0.999797175631493 0.999999078280314 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 51.3558084523276 1 2027.5 5574 False False 3.95341361608213 0.31739219148065 207.323829234655 0 0 0.00017696843241753 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4316 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Gln308* Rv2752c_p.Gln308* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 3 1 20843 27467 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999963594000291 0.999797175631493 0.999999078280314 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 51.3558084523276 1 2027.5 5574 False False 3.95341361608213 0.31739219148065 207.323829234655 0 0 0.00017696843241753 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4169 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 1 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Gln367Pro Rv2752c_p.Gln367Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 5 0 20841 27468 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 1 0.999865711673152 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 5315 5574 False False Inf 1.20760984683633 Inf 0 0 0.000176985413634466 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 13370 21313 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 1 0.999826933785262 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 4278 4479 False False 0 0 0 0 0 0 0 Inf 1.05210128917758 Inf 0 0 0.000275869155324334 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Gln367* Rv2752c_p.Gln367* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Gln417* Rv2752c_p.Gln417* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 51.3533466119536 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 62.1009148060541 1 1642.5 4479 False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 0 0 0.000275827900298067 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Gln485Arg Rv2752c_p.Gln485Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5229 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Gln485Pro Rv2752c_p.Gln485Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 5121 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4119 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Gln531Glu Rv2752c_p.Gln531Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5272 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4246 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Gln531Pro Rv2752c_p.Gln531Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5513 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4429 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Gln531* Rv2752c_p.Gln531* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 5440 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4371 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Gln548fs Rv2752c_p.Gln548fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5464 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Glu114Gly Rv2752c_p.Glu114Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 6 20846 27462 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 0 0 0.4592581264399 0 0 0.975 0 0 0.4592581264399 0 0 51.3390841836116 1 2027.5 5574 False False 0 0 1.11900921779861 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 6 13374 21307 0 0 0.000275786657608973 0.999718481677849 0.999387354605726 0.999896680954833 0 0 0.4592581264399 0 0 0.975 0 0 0.4592581264399 0 0 62.077084521233 1 1005 4479 False False 0 0 0 0 0 0 0 0 0 1.35335561005417 0 0 0.000275786657608973 0.999718481677849 0.999387354605726 0.999896680954833 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Glu130Lys Rv2752c_p.Glu130Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 5330 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4291 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Glu140fs Rv2752c_p.Glu140fs 2 frameshift (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18880616510555 0.264079043314886 541.5 5574 False False 0.439194051331254 0.00837049629364692 5.4704842261679 0 0 0.000176951454458875 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48598624162872 0.526186417038858 925 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Glu142Gly Rv2752c_p.Glu142Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5347 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Glu142* Rv2752c_p.Glu142* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5417 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4354 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Glu207Lys Rv2752c_p.Glu207Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Glu207* Rv2752c_p.Glu207* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5348 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Glu217Asp Rv2752c_p.Glu217Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Glu217* Rv2752c_p.Glu217* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5479 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4400 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Glu26Gly Rv2752c_p.Glu26Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5331 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Glu310Ala Rv2752c_p.Glu310Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01632529799099 0.509386028876591 1135.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Glu310fs Rv2752c_p.Glu310fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5565 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4470 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Glu322* Rv2752c_p.Glu322* 2 stop_gained (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5366 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Glu345Lys Rv2752c_p.Glu345Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5349 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4304 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Glu345* Rv2752c_p.Glu345* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5284 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4255 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Glu346fs Rv2752c_p.Glu346fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5254 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4230 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Glu35Asp Rv2752c_p.Glu35Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Glu35fs Rv2752c_p.Glu35fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5566 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4471 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Glu380Ala Rv2752c_p.Glu380Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Glu380Lys Rv2752c_p.Glu380Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5178 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4170 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Glu380* Rv2752c_p.Glu380* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5395 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4337 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Glu424Gly Rv2752c_p.Glu424Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5453 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4378 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Glu464Gly Rv2752c_p.Glu464Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5418 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Glu464Lys Rv2752c_p.Glu464Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5156 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4149 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Glu499fs Rv2752c_p.Glu499fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 6 0 20840 27468 0.000287825002398541 0.000105633792978048 0.000626367784710498 1 0.999865711673152 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 5199 5574 False False Inf 1.55167078958407 Inf 0 0 0.000176993905465082 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 6 0 13368 21313 0.000448631673396141 0.000164657143425453 0.000976224581517196 1 0.999826933785262 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 4187 4479 False False 0 0 0 0 0 0 0 Inf 1.87681913692541 Inf 0 0 0.00027591042269331 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Glu499Gly Rv2752c_p.Glu499Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5367 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4317 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Glu499* Rv2752c_p.Glu499* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Glu505Gln Rv2752c_p.Glu505Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5419 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4355 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Glu516* Rv2752c_p.Glu516* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5465 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Glu543fs Rv2752c_p.Glu543fs 2 frameshift (see "Genomic_coordinates" sheet) 1 4 0 4 11 5 20835 27463 0.000527679171063993 0.000263444034397523 0.000943967185544106 0.999817970001456 0.999575254267103 0.999940892797913 0.6875 0.413379363548641 0.889830045282882 0 0 0.602364635616474 0 0 0.521823750104981 0 0 1.99702796742245 0.139167947872477 361 5574 False False 2.8998608111351 0.928687468478758 10.647805641112 0 0 0.000177036376844338 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 7 3 13367 21310 0.000523403618962165 0.000210460468745924 0.00107811225334149 0.999859240838924 0.999588697652472 0.999970971136275 0.7 0.347547149940002 0.933260488822265 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.48939706943999 0.52623001493827 977.5 4479 False False 0 0 0 0 0 0 0 3.71985736016558 0.848991347451885 22.2950894269216 0 0 0.000275931061008045 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Glu543* Rv2752c_p.Glu543* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5536 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4449 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Glu54Ala Rv2752c_p.Glu54Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 3 4 20843 27464 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999854376001165 0.999627187086024 0.999960320981843 0.428571428571428 0.0989882784425078 0.815948432359917 0 0 0.841886116991581 0 0 0.602364635616474 0 0 7.01648763390984 0.509387584146166 1155.5 5574 False False 0.988245454109293 0.144734627190883 5.84310835075667 0 0 0.00017696843241753 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 3 13373 21310 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999859240838924 0.999588697652472 0.999970971136275 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.48558807285294 0.526181327783453 903.5 4479 False False 0 0 0 0 0 0 0 0.531169769934445 0.010122018243966 6.61631049307563 0 0 0.000275807277411719 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Glu54Gly Rv2752c_p.Glu54Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5368 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Glu557Gly Rv2752c_p.Glu557Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5230 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4211 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Glu68Asp Rv2752c_p.Glu68Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 15 20846 27453 0 0 0.00017694296670111 0.999453910004368 0.999099467294252 0.999694326386446 0 0 0.218019360910534 NA NA NA 0 0 0.218019360910534 NA NA NA NA 5350 5574 False False 0 0 0.367219809598921 0 0 0.00017694296670111 0.999453910004368 0.999099467294252 0.999694326386446 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 15 13374 21298 0 0 0.000275786657608973 0.999296204194623 0.998839461100611 0.999606039023746 0 0 0.218019360910534 NA NA NA 0 0 0.218019360910534 NA NA NA NA 4305 4479 False False 0 0 0 0 0 0 0 0 0 0.444098942662297 0 0 0.000275786657608973 0.999296204194623 0.998839461100611 0.999606039023746 2 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Glu68* Rv2752c_p.Glu68* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5122 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4120 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Glu75* Rv2752c_p.Glu75* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5420 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4356 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Glu84Asp Rv2752c_p.Glu84Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5273 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4247 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Gly104Ala Rv2752c_p.Gly104Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 1 4 20845 27464 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999854376001165 0.999627187086024 0.999960320981843 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 1.99614374716563 0.139122901336525 342.5 5574 False False 0.329383545214679 0.00669260119676484 3.32889360843958 0 0 0.000176951454458875 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48598624162872 0.526186417038858 925 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Gly104Asp Rv2752c_p.Gly104Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5137 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Gly15Arg Rv2752c_p.Gly15Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Gly161Arg Rv2752c_p.Gly161Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5302 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Gly161Cys Rv2752c_p.Gly161Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5396 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4338 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Gly161fs Rv2752c_p.Gly161fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5378 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4324 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Gly161Ser Rv2752c_p.Gly161Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 71 137 20775 27331 0.00340592919504941 0.00266098821822608 0.00429420306078129 0.995012378039901 0.99410649615119 0.995810960864036 0.341346153846153 0.277187073063756 0.410101885110326 NA NA NA 0 0 0.0265668510962833 NA NA NA NA 5421 5574 False True 0.681792581271355 0.504207162115027 0.915173609198468 0 0 0.000177547627847143 0.995012378039901 0.99410649615119 0.995810960864036 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 41 96 13333 21217 0.00306564976820696 0.00220083411622644 0.00415662587679321 0.995495706845587 0.994502229063876 0.996350030374114 0.2992700729927 0.224072179208062 0.383373374609758 NA NA NA 0 0 0.0376969216235875 NA NA NA NA 4357 4479 False True 0 1 1 0 0 0 0 0.679624021850546 0.459240444749425 0.99007896780403 0 0 0.00027663460546986 0.995495706845587 0.994502229063876 0.996350030374114 14 5) Not assoc w R UP from Uncertain to NotAwR yes 4 +Isoniazid Rv2752c p.Gly163Arg Rv2752c_p.Gly163Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 5441 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4372 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Gly169Arg Rv2752c_p.Gly169Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5567 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4472 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Gly169Val Rv2752c_p.Gly169Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 5480 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4401 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Gly180Cys Rv2752c_p.Gly180Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5369 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4318 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Gly180fs Rv2752c_p.Gly180fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5316 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4279 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Gly187Asp Rv2752c_p.Gly187Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 5285 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4256 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Gly210Arg Rv2752c_p.Gly210Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 5200 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4188 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Gly210Asp Rv2752c_p.Gly210Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 5201 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4189 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Gly210fs Rv2752c_p.Gly210fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Gly219Ser Rv2752c_p.Gly219Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5514 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4430 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Gly228Cys Rv2752c_p.Gly228Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5397 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4339 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Gly228fs Rv2752c_p.Gly228fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5157 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4150 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Gly22Cys Rv2752c_p.Gly22Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Gly22Ser Rv2752c_p.Gly22Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5442 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Gly22Val Rv2752c_p.Gly22Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5241 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4218 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Gly231Val Rv2752c_p.Gly231Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 5568 5574 False False 0 0 1.43785249906968 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 13374 21308 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 4473 4479 False False 0 0 0 0 0 0 0 0 0 1.73894646374006 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Gly256fs Rv2752c_p.Gly256fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5537 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4450 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Gly256Ser Rv2752c_p.Gly256Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5158 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Gly256Val Rv2752c_p.Gly256Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Gly263Asp Rv2752c_p.Gly263Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5231 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4212 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Gly263fs Rv2752c_p.Gly263fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5422 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4358 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Gly28Cys Rv2752c_p.Gly28Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5370 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Gly28Ser Rv2752c_p.Gly28Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 15 0 20831 27468 0.000719562505996354 0.000402787826414311 0.00118653165660568 1 0.999865711673152 1 1 0.781980639089466 1 NA NA NA NA NA NA NA NA NA NA 5202 5574 False False Inf 4.72839222701803 Inf 0 0 0.000177070368626196 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 15 0 13359 21313 0.00112157918349035 0.000627870944551516 0.00184920065907577 1 0.999826933785262 1 1 0.781980639089466 1 NA NA NA NA NA NA NA NA NA NA 4190 4479 False False 0 0 0 0 0 0 0 Inf 5.72086110443017 Inf 0 0 0.000276096278743345 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Gly28Val Rv2752c_p.Gly28Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5255 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4231 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Gly306Asp Rv2752c_p.Gly306Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5405 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4346 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Gly321Thr Rv2752c_p.Gly321Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 5203 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Gly331fs Rv2752c_p.Gly331fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 51.3533466119536 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Gly331Ser Rv2752c_p.Gly331Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5274 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Gly331Val Rv2752c_p.Gly331Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5190 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4180 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Gly343Cys Rv2752c_p.Gly343Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Gly350Glu Rv2752c_p.Gly350Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5232 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Gly374Arg Rv2752c_p.Gly374Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5123 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Gly374Asp Rv2752c_p.Gly374Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5423 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4359 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Gly387Arg Rv2752c_p.Gly387Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5515 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4431 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Gly387Glu Rv2752c_p.Gly387Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5443 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4373 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Gly38fs Rv2752c_p.Gly38fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5351 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4306 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Gly38Ser Rv2752c_p.Gly38Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 51.349017027227 1 2027.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Gly398Arg Rv2752c_p.Gly398Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5444 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Gly414Asp Rv2752c_p.Gly414Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5555 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4465 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Gly414Ser Rv2752c_p.Gly414Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18880616510555 0.264079043314886 541.5 5574 False False 0.439194051331254 0.00837049629364692 5.4704842261679 0 0 0.000176951454458875 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 1 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Gly426Ala Rv2752c_p.Gly426Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Gly440Ser Rv2752c_p.Gly440Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 7.01573328293188 0.509380354735251 864 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Gly445fs Rv2752c_p.Gly445fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 5538 5574 False False Inf 0.869878292971449 Inf 0 0 0.000176976922618654 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4451 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Gly451Arg Rv2752c_p.Gly451Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5317 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4280 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Gly451Asp Rv2752c_p.Gly451Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Gly451Ser Rv2752c_p.Gly451Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 5 0 20841 27468 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 1 0.999865711673152 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 5499 5574 False False Inf 1.20760984683633 Inf 0 0 0.000176985413634466 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 5 0 13369 21313 0.000373859727830118 0.000121402023062639 0.000872246401868143 1 0.999826933785262 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 4416 4479 False False 0 0 0 0 0 0 0 Inf 1.46057233596553 Inf 0 0 0.000275889787465637 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Gly458Arg Rv2752c_p.Gly458Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 5398 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4340 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Gly458Asp Rv2752c_p.Gly458Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5159 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4151 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Gly463Arg Rv2752c_p.Gly463Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Gly46Cys Rv2752c_p.Gly46Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5371 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4319 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Gly46fs Rv2752c_p.Gly46fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5191 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4181 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Gly482Val Rv2752c_p.Gly482Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Gly484Ser Rv2752c_p.Gly484Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5424 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Gly496Ala Rv2752c_p.Gly496Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 1 6 20845 27462 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999781564001747 0.999524617886493 0.999919833755107 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.11906289991934 0.040214073694581 205 5574 False False 0.219573039098105 0.00477770915407814 1.81014820057657 0 0 0.000176951454458875 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 1 5 13373 21308 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999765401398207 0.999452610763328 0.999923822225278 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.73907646387712 0.163960168380046 259.5 4479 False False 0 0 0 0 0 0 0 0.318671950945935 0.00674139558547252 2.84834809554519 0 0 0.000275807277411719 0.999765401398207 0.999452610763328 0.999923822225278 2 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Gly496Asp Rv2752c_p.Gly496Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5262 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4237 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Gly496fs Rv2752c_p.Gly496fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5124 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4121 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Gly51Ser Rv2752c_p.Gly51Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5332 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Gly542Glu Rv2752c_p.Gly542Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Gly56fs Rv2752c_p.Gly56fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 11 2 20835 27466 0.000527679171063993 0.000263444034397523 0.000943967185544106 0.999927188000582 0.999737003036386 0.999991182007438 0.846153846153846 0.545528944323442 0.980793328017471 0 0 0.975 0 0 0.841886116991581 0 0 51.3736428004428 1 2027.5 5574 False False 7.25044396448284 1.58206940172597 67.4160671725854 0 0 0.000177036376844338 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 7 2 13367 21311 0.000523403618962165 0.000210460468745924 0.00107811225334149 0.999906160559283 0.999661061221376 0.999988635406343 0.777777777777777 0.399906426283687 0.971855026522101 0 0 0.975 0 0 0.841886116991581 0 0 62.1212094299475 1 1642.5 4479 False False 0 0 0 0 0 0 0 5.58004787910525 1.06221404733015 55.0152654432543 0 0 0.000275931061008045 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Gly56Val Rv2752c_p.Gly56Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5275 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4248 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Gly82Arg Rv2752c_p.Gly82Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5481 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4402 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Gly82Glu Rv2752c_p.Gly82Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 3 1 20843 27467 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999963594000291 0.999797175631493 0.999999078280314 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 5179 5574 False False 3.95341361608213 0.31739219148065 207.323829234655 0 0 0.00017696843241753 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 3 1 13371 21312 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999953080279641 0.999738608085756 0.999998812096234 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 4171 4479 False False 0 0 0 0 0 0 0 4.78169172088849 0.383875689805931 250.696170545132 0 0 0.000275848526268708 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Gly88Arg Rv2752c_p.Gly88Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5556 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Gly88Glu Rv2752c_p.Gly88Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 5372 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4320 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 2 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Gly88Trp Rv2752c_p.Gly88Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 5466 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4388 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Gly88Val Rv2752c_p.Gly88Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5406 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.His136Asp Rv2752c_p.His136Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01632529799099 0.509386028876591 1135.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.His148Arg Rv2752c_p.His148Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5539 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4452 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.His148dup Rv2752c_p.His148dup 2 inframe_insertion (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5204 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4191 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.His148Gln Rv2752c_p.His148Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.His148Pro Rv2752c_p.His148Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 5 0 20841 27468 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 1 0.999865711673152 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 5276 5574 False False Inf 1.20760984683633 Inf 0 0 0.000176985413634466 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4249 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.His148Tyr Rv2752c_p.His148Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 5318 5574 False False Inf 0.869878292971449 Inf 0 0 0.000176976922618654 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 13370 21313 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 1 0.999826933785262 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 4281 4479 False False 0 0 0 0 0 0 0 Inf 1.05210128917758 Inf 0 0 0.000275869155324334 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.His167Arg Rv2752c_p.His167Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 7 3 20839 27465 0.000335795836131632 0.000135017659185429 0.000691744589626827 0.999890782000873 0.99968085216583 0.999977476056514 0.7 0.347547149940002 0.933260488822265 0 0 0.841886116991581 0 0 0.707598226178713 0 0 7.0180899751867 0.509402947816543 1203 5574 False False 3.07524353375881 0.70193019624619 18.4306658389899 0 0 0.00017700239811062 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 5 3 13369 21310 0.000373859727830118 0.000121402023062639 0.000872246401868143 0.999859240838924 0.999588697652472 0.999970971136275 0.625 0.244863216366551 0.914766585862746 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.48812702402024 0.526213778991498 968.5 4479 False False 0 0 0 0 0 0 0 2.65664347869449 0.516758123120163 17.1115025092299 0 0 0.000275889787465637 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.His167Pro Rv2752c_p.His167Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5242 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4219 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.His223Arg Rv2752c_p.His223Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.His223Tyr Rv2752c_p.His223Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 7.01573328293188 0.509380354735251 864 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.His323Arg Rv2752c_p.His323Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5138 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4133 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.His36Gln Rv2752c_p.His36Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.His371Arg Rv2752c_p.His371Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5467 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4389 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.His371Asp Rv2752c_p.His371Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.His371fs Rv2752c_p.His371fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5425 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4360 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.His371Tyr Rv2752c_p.His371Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 6 2 20840 27466 0.000287825002398541 0.000105633792978048 0.000626367784710498 0.999927188000582 0.999737003036386 0.999991182007438 0.75 0.349144205587175 0.968145973750055 0 0 0.975 0 0 0.841886116991581 0 0 51.3613269620582 1 2027.5 5574 False False 3.95383877159309 0.706870204411237 40.0621427029589 0 0 0.000176993905465082 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 2 13371 21311 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999906160559283 0.999661061221376 0.999988635406343 0.6 0.146632799634673 0.947255049473683 0 0 0.975 0 0 0.841886116991581 0 0 62.1026435994552 1 1642.5 4479 False False 0 0 0 0 0 0 0 2.39073367736145 0.273835790357664 28.6284716983702 0 0 0.000275848526268708 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.His375Arg Rv2752c_p.His375Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5125 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.His375fs Rv2752c_p.His375fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5160 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4152 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.His375Tyr Rv2752c_p.His375Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.His397Arg Rv2752c_p.His397Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 16 0 20830 27468 0.000767533339729444 0.000438773245501675 0.00124612759964746 1 0.999865711673152 1 1 0.794092785792177 1 NA NA NA NA NA NA NA NA NA NA 5286 5574 False False Inf 5.0841332374657 Inf 0 0 0.000177078868611313 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 12 0 13362 21313 0.000897263346792283 0.000463712283458933 0.00156681338714949 1 0.999826933785262 1 1 0.735351530602948 1 NA NA NA NA NA NA NA NA NA NA 4257 4479 False False 0 0 0 0 0 0 0 Inf 4.43112457890131 Inf 0 0 0.000276034298911909 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.His397Tyr Rv2752c_p.His397Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 5540 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4453 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.His491_Gln531del Rv2752c_p.His491_Gln531del 2 inframe_deletion (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5352 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.His491fs Rv2752c_p.His491fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 5333 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4292 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.His491Tyr Rv2752c_p.His491Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 1 7 2 7 20844 27461 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999745158002038 0.999474999027776 0.999897534357495 0.222222222222222 0.0281449734778982 0.600093573716312 0.125 0.0031597235312519 0.526509670875206 0.125 0.0031597235312519 0.526509670875206 0.188207637689502 0.00418010085016049 1.46520347536299 0.149408090010834 368 5574 False False 0.376415275379005 0.0381509889597215 1.97729867984898 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 0.999745158002038 0.999474999027776 0.999897534357495 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 1 7 13373 21306 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.99967156195749 0.999323409938814 0.999867941002665 0.125 0.0031597235312519 0.526509670875206 0 0 0.409616397225003 0 0 0.409616397225003 0 0 1.10560777754281 0.0484416089718066 135 4479 False False 0 0 0 0 0 0 0 0.227601457093717 0.00505385949080816 1.77192833352817 0 0 0.000275807277411719 0.99967156195749 0.999323409938814 0.999867941002665 1 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.His493Arg Rv2752c_p.His493Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 5303 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4271 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.His493Pro Rv2752c_p.His493Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 6 3 20840 27465 0.000287825002398541 0.000105633792978048 0.000626367784710498 0.999890782000873 0.99968085216583 0.999977476056514 0.666666666666666 0.29929505620854 0.925145368580308 NA NA NA 0 0 0.707598226178713 NA NA NA NA 5180 5574 False False 2.63579654510556 0.562830574439234 16.2901193363597 0 0 0.000176993905465082 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 4 3 13370 21310 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 0.999859240838924 0.999588697652472 0.999970971136275 0.571428571428571 0.184051567640083 0.901011721557492 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4172 4479 False False 0 0 0 0 0 0 0 2.1251558214909 0.359459073814522 14.5112646280518 0 0 0.000275869155324334 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.His52Asp Rv2752c_p.His52Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.His66fs Rv2752c_p.His66fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 5126 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4122 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.His66Tyr Rv2752c_p.His66Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5319 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4282 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.His81Arg Rv2752c_p.His81Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 4 3 20842 27465 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999890782000873 0.99968085216583 0.999977476056514 0.571428571428571 0.184051567640083 0.901011721557492 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18926519666227 0.264093566162961 563 5574 False False 1.75702907590442 0.297192930207644 11.9979296337129 0 0 0.000176976922618654 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 4 3 13370 21310 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 0.999859240838924 0.999588697652472 0.999970971136275 0.571428571428571 0.184051567640083 0.901011721557492 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85767239118891 0.289316132442022 407 4479 False False 0 0 0 0 0 0 0 2.1251558214909 0.359459073814522 14.5112646280518 0 0 0.000275869155324334 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.His81Asp Rv2752c_p.His81Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5399 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4341 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.His81Pro Rv2752c_p.His81Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5557 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4466 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.His81Tyr Rv2752c_p.His81Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 3 5 20843 27463 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999817970001456 0.999575254267103 0.999940892797913 0.375 0.0852334141372535 0.755136783633448 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.43806008939138 0.0743503996915812 270.5 5574 False False 0.790567576644437 0.122780413850952 4.06394022809159 0 0 0.00017696843241753 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 3 4 13371 21309 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999812321118566 0.999519537882235 0.999948861529775 0.428571428571428 0.0989882784425078 0.815948432359917 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.4147462040928 0.305464224243379 424 4479 False False 0 0 0 0 0 0 0 1.19525465559793 0.17505505093835 7.0663575727929 0 0 0.000275848526268708 0.999812321118566 0.999519537882235 0.999948861529775 1 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.His83Arg Rv2752c_p.His83Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 4 5 20842 27463 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999817970001456 0.999575254267103 0.999940892797913 0.444444444444444 0.136995662265166 0.787991493221131 NA NA NA 0 0 0.521823750104981 NA NA NA NA 5243 5574 False False 1.05414067747816 0.209146339999741 4.89812409436146 0 0 0.000176976922618654 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 3 2 13371 21311 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999906160559283 0.999661061221376 0.999988635406343 0.6 0.146632799634673 0.947255049473683 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4220 4479 False False 0 0 0 0 0 0 0 2.39073367736145 0.273835790357664 28.6284716983702 0 0 0.000275848526268708 0.999906160559283 0.999661061221376 0.999988635406343 1 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.His83Asn Rv2752c_p.His83Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5205 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.His83Pro Rv2752c_p.His83Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 7 0 20839 27468 0.000335795836131632 0.000135017659185429 0.000691744589626827 1 0.999865711673152 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 5482 5574 False False Inf 1.89951899263229 Inf 0 0 0.00017700239811062 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 5 0 13369 21313 0.000373859727830118 0.000121402023062639 0.000872246401868143 1 0.999826933785262 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 4403 4479 False False 0 0 0 0 0 0 0 Inf 1.46057233596553 Inf 0 0 0.000275889787465637 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.His83Tyr Rv2752c_p.His83Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 51.3533466119536 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.His86Arg Rv2752c_p.His86Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 1 20843 27467 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999963594000291 0.999797175631493 0.999999078280314 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 51.3558084523276 1 2027.5 5574 False False 3.95341361608213 0.31739219148065 207.323829234655 0 0 0.00017696843241753 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4404 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.His86fs Rv2752c_p.His86fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 5206 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4192 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.His86Pro Rv2752c_p.His86Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5353 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.His86Tyr Rv2752c_p.His86Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 5244 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4221 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ile121fs Rv2752c_p.Ile121fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5500 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4417 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ile121Met Rv2752c_p.Ile121Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 5192 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4182 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ile165fs Rv2752c_p.Ile165fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ile165Ser Rv2752c_p.Ile165Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5263 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4238 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ile165Val Rv2752c_p.Ile165Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ile171fs Rv2752c_p.Ile171fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ile234Arg Rv2752c_p.Ile234Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ile248Thr Rv2752c_p.Ile248Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ile249Ser Rv2752c_p.Ile249Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ile24Val Rv2752c_p.Ile24Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5379 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4325 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ile287Val Rv2752c_p.Ile287Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 5558 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ile303Ser Rv2752c_p.Ile303Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5468 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4390 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ile358dup Rv2752c_p.Ile358dup 2 inframe_insertion (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 5287 5574 False False Inf 0.869878292971449 Inf 0 0 0.000176976922618654 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 13370 21313 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 1 0.999826933785262 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 4258 4479 False False 0 0 0 0 0 0 0 Inf 1.05210128917758 Inf 0 0 0.000275869155324334 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ile42Asn Rv2752c_p.Ile42Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5501 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4418 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ile438Thr Rv2752c_p.Ile438Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5469 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4391 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ile43fs Rv2752c_p.Ile43fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5426 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ile43Ser Rv2752c_p.Ile43Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5373 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ile43Val Rv2752c_p.Ile43Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 5516 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4432 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ile453Thr Rv2752c_p.Ile453Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ile460Val Rv2752c_p.Ile460Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ile527fs Rv2752c_p.Ile527fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ile527Met Rv2752c_p.Ile527Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5380 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4326 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ile527Thr Rv2752c_p.Ile527Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5502 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4419 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ile527Val Rv2752c_p.Ile527Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5483 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ile529fs Rv2752c_p.Ile529fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5320 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ile529Ser Rv2752c_p.Ile529Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 3 3 20843 27465 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999890782000873 0.99968085216583 0.999977476056514 0.5 0.118117248757025 0.881882751242974 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18911217145806 0.264088724182152 560.5 5574 False False 1.31770858321738 0.176469385678871 9.83712695959095 0 0 0.00017696843241753 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 3 3 13371 21310 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999859240838924 0.999588697652472 0.999970971136275 0.5 0.118117248757025 0.881882751242974 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85738382606555 0.289303960895733 405 4479 False False 0 0 0 0 0 0 0 1.59374766285244 0.213424225946693 11.9045637110481 0 0 0.000275848526268708 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ile551Thr Rv2752c_p.Ile551Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 7.01573328293188 0.509380354735251 864 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.48495357236853 0.526173219289417 690 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ile556Val Rv2752c_p.Ile556Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5334 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4293 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ile60fs Rv2752c_p.Ile60fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5217 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4202 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ile87Thr Rv2752c_p.Ile87Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ile90fs Rv2752c_p.Ile90fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5207 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4193 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Leu109Trp Rv2752c_p.Leu109Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 5264 5574 False False 0.439194051331254 0.00837049629364692 5.4704842261679 0 0 0.000176951454458875 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 3 13373 21310 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999859240838924 0.999588697652472 0.999970971136275 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4239 4479 False False 0 0 0 0 0 0 0 0.531169769934445 0.010122018243966 6.61631049307563 0 0 0.000275807277411719 0.999859240838924 0.999588697652472 0.999970971136275 1 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Leu111Arg Rv2752c_p.Leu111Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 5233 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4213 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Leu111Pro Rv2752c_p.Leu111Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5139 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Leu11fs Rv2752c_p.Leu11fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5407 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Leu154* Rv2752c_p.Leu154* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5140 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4134 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Leu166Arg Rv2752c_p.Leu166Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5408 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4347 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Leu166Pro Rv2752c_p.Leu166Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 5541 5574 False False Inf 0.869878292971449 Inf 0 0 0.000176976922618654 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4454 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Leu16Phe Rv2752c_p.Leu16Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5161 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4153 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Leu16Trp Rv2752c_p.Leu16Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Leu176Ser Rv2752c_p.Leu176Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 4 1 20842 27467 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999963594000291 0.999797175631493 0.999999078280314 0.8 0.28358206388191 0.994949236620532 NA NA NA 0 0 0.975 NA NA NA NA 5218 5574 False False 5.27147106803569 0.521589398427432 259.279173455301 0 0 0.000176976922618654 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 4 1 13370 21312 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 0.999953080279641 0.999738608085756 0.999998812096234 0.8 0.28358206388191 0.994949236620532 NA NA NA 0 0 0.975 NA NA NA NA 4203 4479 False False 0 0 0 0 0 0 0 6.37606581899775 0.630846560224411 313.513380938872 0 0 0.000275869155324334 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Leu185Pro Rv2752c_p.Leu185Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 2 3 20844 27465 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999890782000873 0.99968085216583 0.999977476056514 0.4 0.0527449505263169 0.853367200365326 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18895916093986 0.264083883232833 556.5 5574 False False 0.878430243715217 0.0733354884838472 7.66963698207431 0 0 0.000176959943030976 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Leu185Ser Rv2752c_p.Leu185Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5277 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Leu191Phe Rv2752c_p.Leu191Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5503 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4420 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Leu191Pro Rv2752c_p.Leu191Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 51.349017027227 1 2027.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Leu199fs Rv2752c_p.Leu199fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 5381 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4327 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Leu199Ser Rv2752c_p.Leu199Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5569 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4474 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Leu200Arg Rv2752c_p.Leu200Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Leu21Pro Rv2752c_p.Leu21Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5570 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4475 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Leu222Arg Rv2752c_p.Leu222Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 51.3533466119536 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 62.1009148060541 1 1642.5 4479 False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 0 0 0.000275827900298067 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Leu222Gln Rv2752c_p.Leu222Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Leu222Pro Rv2752c_p.Leu222Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4433 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Leu225His Rv2752c_p.Leu225His 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Leu225Pro Rv2752c_p.Leu225Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 5 1 20841 27467 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.999963594000291 0.999797175631493 0.999999078280314 0.833333333333333 0.358765421002325 0.99578925548551 0 0 0.975 0 0 0.975 0 0 51.360732841256 1 2027.5 5574 False False 6.58965500695744 0.737267067818355 311.215258952954 0 0 0.000176985413634466 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 1 13371 21312 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999953080279641 0.999738608085756 0.999998812096234 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 62.1055547471297 1 1642.5 4479 False False 0 0 0 0 0 0 0 4.78169172088849 0.383875689805931 250.696170545132 0 0 0.000275848526268708 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Leu276Pro Rv2752c_p.Leu276Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5265 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4240 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Leu286Arg Rv2752c_p.Leu286Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5181 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4173 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Leu302_Thr305del Rv2752c_p.Leu302_Thr305del 2 inframe_deletion (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5335 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4294 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Leu315* Rv2752c_p.Leu315* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5400 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4342 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Leu333fs Rv2752c_p.Leu333fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5336 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4295 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Leu333Pro Rv2752c_p.Leu333Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 5470 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4392 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Leu336del Rv2752c_p.Leu336del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5542 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Leu336fs Rv2752c_p.Leu336fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Leu355Arg Rv2752c_p.Leu355Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5304 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4272 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Leu37Pro Rv2752c_p.Leu37Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 51.3533466119536 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 62.1009148060541 1 1642.5 4479 False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 0 0 0.000275827900298067 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Leu37Val Rv2752c_p.Leu37Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 5471 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4393 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Leu381Arg Rv2752c_p.Leu381Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 5 0 20841 27468 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 1 0.999865711673152 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 5162 5574 False False Inf 1.20760984683633 Inf 0 0 0.000176985413634466 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 13370 21313 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 1 0.999826933785262 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 4154 4479 False False 0 0 0 0 0 0 0 Inf 1.05210128917758 Inf 0 0 0.000275869155324334 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Leu382Pro Rv2752c_p.Leu382Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5182 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4174 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Leu384Arg Rv2752c_p.Leu384Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5141 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4135 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Leu384His Rv2752c_p.Leu384His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5127 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4123 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Leu384Val Rv2752c_p.Leu384Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Leu403Arg Rv2752c_p.Leu403Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 5472 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4394 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Leu403Met Rv2752c_p.Leu403Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 5517 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4434 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Leu40fs Rv2752c_p.Leu40fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Leu41Ser Rv2752c_p.Leu41Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 51.3533466119536 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 62.1009148060541 1 1642.5 4479 False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 0 0 0.000275827900298067 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Leu41Trp Rv2752c_p.Leu41Trp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5409 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Leu422Phe Rv2752c_p.Leu422Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5278 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4250 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Leu431Arg Rv2752c_p.Leu431Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5410 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Leu452Ser Rv2752c_p.Leu452Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 5473 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4395 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Leu452Val Rv2752c_p.Leu452Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5445 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4374 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Leu466Pro Rv2752c_p.Leu466Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5382 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4328 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Leu468fs Rv2752c_p.Leu468fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Leu468Phe Rv2752c_p.Leu468Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5543 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Leu487Phe Rv2752c_p.Leu487Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 57 2 55 25 64 20821 27404 0.00119927084332725 0.000776250516059497 0.00176985477840228 0.99767001601864 0.997025622876796 0.998205180195353 0.280898876404494 0.190734263110193 0.386155512974294 0.0350877192982456 0.00427789494053177 0.121070663196201 0.0303030303030303 0.00369113896142986 0.105216648579651 0.0478607699394405 0.00566437562647339 0.181334090845243 1.30926304519128e-11 14 5574 True False 0.514129364583833 0.310109594798068 0.828314031598246 9.60476396292561e-05 1.16320264101014e-05 0.000346913574091278 0.99767001601864 0.997025622876796 0.998205180195353 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 43 2 41 22 50 13352 21263 0.00164498280245251 0.00103118012105387 0.00248947070088324 0.997654013982076 0.996908265309841 0.998258277916569 0.305555555555555 0.202379869430067 0.425316653314475 0.0465116279069767 0.00568325697874796 0.158111458308697 0.0384615384615384 0.00469228900927086 0.132128407276802 0.0776827076239606 0.00909484269113445 0.299178122072847 3.76904144298977e-07 18 4479 True False 0 0 0 0 0 0 0 0.700698022768124 0.403875817797567 1.17924477994118 0.000149767859817283 1.81380972863362e-05 0.000540907180910465 0.997654013982076 0.996908265309841 0.998258277916569 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Leu48Ser Rv2752c_p.Leu48Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5288 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4259 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Leu492Arg Rv2752c_p.Leu492Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 3 3 20843 27465 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999890782000873 0.99968085216583 0.999977476056514 0.5 0.118117248757025 0.881882751242974 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18911217145806 0.264088724182152 560.5 5574 False False 1.31770858321738 0.176469385678871 9.83712695959095 0 0 0.00017696843241753 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 3 2 13371 21311 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999906160559283 0.999661061221376 0.999988635406343 0.6 0.146632799634673 0.947255049473683 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.4872555868813 0.526202640597156 962.5 4479 False False 0 0 0 0 0 0 0 2.39073367736145 0.273835790357664 28.6284716983702 0 0 0.000275848526268708 0.999906160559283 0.999661061221376 0.999988635406343 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Leu504fs Rv2752c_p.Leu504fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4421 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 3 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Leu504Pro Rv2752c_p.Leu504Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5183 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4175 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Leu515Arg Rv2752c_p.Leu515Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5427 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4361 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Leu5Phe Rv2752c_p.Leu5Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 4 20845 27464 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999854376001165 0.999627187086024 0.999960320981843 0.2 0.00505076337946806 0.716417936118089 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.18869006320801 0.264075370383126 529 5574 False False 0.329383545214679 0.00669260119676484 3.32889360843958 0 0 0.000176951454458875 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 3 13373 21310 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999859240838924 0.999588697652472 0.999970971136275 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.48558807285294 0.526181327783453 903.5 4479 False False 0 0 0 0 0 0 0 0.531169769934445 0.010122018243966 6.61631049307563 0 0 0.000275807277411719 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Leu5Val Rv2752c_p.Leu5Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Leu61Pro Rv2752c_p.Leu61Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 51.3533466119536 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Leu77Arg Rv2752c_p.Leu77Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Leu77Pro Rv2752c_p.Leu77Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 5208 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4194 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Leu93Arg Rv2752c_p.Leu93Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 9 4 20837 27464 0.000431737503597812 0.000197436276106449 0.000819413341228355 0.999854376001165 0.999627187086024 0.999960320981843 0.692307692307692 0.385738338249294 0.909079605427903 0 0 0.602364635616474 0 0 0.602364635616474 0 0 1.99690914229336 0.139161891813698 360 5574 False False 2.96559005615011 0.827533510717841 13.1780977796214 0 0 0.000177019385846931 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 6 4 13368 21309 0.000448631673396141 0.000164657143425453 0.000976224581517196 0.999812321118566 0.999519537882235 0.999948861529775 0.6 0.262378076606945 0.878447741880172 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.41528861025824 0.305455314309637 421 4479 False False 0 0 0 0 0 0 0 2.39104578096947 0.566896063868826 11.5233353829039 0 0 0.00027591042269331 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Leu93fs Rv2752c_p.Leu93fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Leu93Met Rv2752c_p.Leu93Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 51.3533466119536 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Leu93Pro Rv2752c_p.Leu93Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5209 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4195 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Leu94Arg Rv2752c_p.Leu94Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Leu94Phe Rv2752c_p.Leu94Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0337859573643402 Inf 0.431469139379889 746 5574 False False Inf 0.0337859573643402 Inf 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0408616897784423 Inf 0.385562314411739 597 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Leu94Pro Rv2752c_p.Leu94Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 5184 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4176 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Leu96fs Rv2752c_p.Leu96fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Lys106Asn Rv2752c_p.Lys106Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5142 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4136 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Lys115Glu Rv2752c_p.Lys115Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Lys172Gln Rv2752c_p.Lys172Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01632529799099 0.509386028876591 1135.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48598624162872 0.526186417038858 925 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 3 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Lys172Glu Rv2752c_p.Lys172Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 6 1 20840 27467 0.000287825002398541 0.000105633792978048 0.000626367784710498 0.999963594000291 0.999797175631493 0.999999078280314 0.857142857142857 0.421276802956804 0.996389703138099 NA NA NA 0 0 0.975 NA NA NA NA 5446 5574 False False 7.90796545105566 0.959277004805377 363.132004070954 0 0 0.000176993905465082 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 4 1 13370 21312 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 0.999953080279641 0.999738608085756 0.999998812096234 0.8 0.28358206388191 0.994949236620532 NA NA NA 0 0 0.975 NA NA NA NA 4375 4479 False False 0 0 0 0 0 0 0 6.37606581899775 0.630846560224411 313.513380938872 0 0 0.000275869155324334 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Lys172Thr Rv2752c_p.Lys172Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Lys357fs Rv2752c_p.Lys357fs 2 frameshift (see "Genomic_coordinates" sheet) 1 32 0 32 0 32 20846 27436 0 0 0.00017694296670111 0.99883500800932 0.998355773360856 0.999203014115056 0 0 0.108881160679352 0 0 0.108881160679352 0 0 0.108881160679352 0 0 0.160846108594094 1.59469583352172e-08 22 5574 True False 0 0 0.160846108594094 0 0 0.00017694296670111 0.99883500800932 0.998355773360856 0.999203014115056 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 32 0 32 0 32 13374 21281 0 0 0.000275786657608973 0.998498568948529 0.997881082537686 0.998972802621471 0 0 0.108881160679352 0 0 0.108881160679352 0 0 0.108881160679352 0 0 0.194494943651136 2.99304256487093e-07 17 4479 True False 0 0 0 0 0 0 0 0 0 0.194494943651136 0 0 0.000275786657608973 0.998498568948529 0.997881082537686 0.998972802621471 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Lys357Thr Rv2752c_p.Lys357Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 13 20845 27455 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999526722003786 0.99919081619501 0.999747976101462 0.0714285714285714 0.00180678065912538 0.338684489931821 NA NA NA 0 0 0.24705263800047 NA NA NA NA 5526 5574 False False 0.101315570972563 0.00238818580532865 0.674658821461901 0 0 0.000176951454458875 0.999526722003786 0.99919081619501 0.999747976101462 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 8 13373 21305 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999624642237132 0.999260530264256 0.999837933676441 0.111111111111111 0.00280913674659921 0.482496514917337 NA NA NA 0 0 0.369416647552819 NA NA NA NA 4442 4479 False False 0 0 0 0 0 0 0 0.199141927764899 0.00449176289276445 1.48571302597227 0 0 0.000275807277411719 0.999624642237132 0.999260530264256 0.999837933676441 1 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Lys408Arg Rv2752c_p.Lys408Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Lys408Asn Rv2752c_p.Lys408Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5337 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4296 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Lys435Glu Rv2752c_p.Lys435Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 13 37 20833 27431 0.000623620838530173 0.000332092285535748 0.00106617452923529 0.998652978010776 0.998143780847516 0.999051400373341 0.26 0.146300584396554 0.403447678728065 NA NA NA 0 0 0.0948905874149899 NA NA NA NA NA NA False True 0.46262751014827 0.225593495659032 0.890804156113237 0 0 0.00017705337110378 0.998652978010776 0.998143780847516 0.999051400373341 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 12 32 13362 21281 0.000897263346792283 0.000463712283458933 0.00156681338714949 0.998498568948529 0.997881082537686 0.998972802621471 0.272727272727272 0.149576843765308 0.4278964124555 NA NA NA 0 0 0.108881160679352 NA NA NA NA NA NA False True 0 0 0 0 0 1 0 0.597244050291872 0.280049855830217 1.19172719133314 0 0 0.000276034298911909 0.998498568948529 0.997881082537686 0.998972802621471 3 Not assoc w R Previous WHO guidance 4) Not assoc w R - Interim DOWN from NotAwR to NotAwRI yes Prev. WHO 3 +Isoniazid Rv2752c p.Lys446fs Rv2752c_p.Lys446fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 51.3533466119536 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 62.1009148060541 1 1642.5 4479 False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 0 0 0.000275827900298067 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Lys502fs Rv2752c_p.Lys502fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5484 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Lys502Thr Rv2752c_p.Lys502Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5571 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4476 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Lys510Gln Rv2752c_p.Lys510Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 8 0 20838 27468 0.000383766669864722 0.000165697303700768 0.000756032532322191 1 0.999865711673152 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 5572 5574 False False Inf 2.24970730189478 Inf 0 0 0.000177010891571197 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 8 0 13366 21313 0.000598175564528189 0.000258283997825234 0.00117830226263269 1 0.999826933785262 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 4477 4479 False False 0 0 0 0 0 0 0 Inf 2.72130996382454 Inf 0 0 0.000275951702410535 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Lys539Thr Rv2752c_p.Lys539Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5428 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4362 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Met1? Rv2752c_p.Met1? 2 start_lost (see "Genomic_coordinates" sheet) 1 2 0 2 2 2 20844 27466 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999927188000582 0.999737003036386 0.999991182007438 0.5 0.067585986488543 0.932414013511457 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01666191595533 0.509389255488555 1161.5 5574 False False 1.3176933410094 0.0955278435529395 18.1762534351792 0 0 0.000176959943030976 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48598624162872 0.526186417038858 925 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 3 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Met188Lys Rv2752c_p.Met188Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 2 6 2 6 20844 27462 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999781564001747 0.999524617886493 0.999919833755107 0.25 0.0318540262499442 0.650855794412824 0.25 0.0318540262499442 0.650855794412824 0.25 0.0318540262499442 0.650855794412824 0.439167146421032 0.0433460282809438 2.45619176778693 0.479317955570006 831 5574 False False 0.439167146421032 0.0433460282809438 2.45619176778693 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.41420404242617 0.305473156458586 444 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Met266Thr Rv2752c_p.Met266Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Met270Arg Rv2752c_p.Met270Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5411 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4348 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Met312Ile Rv2752c_p.Met312Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 1 5 2 8 20844 27460 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.99970875200233 0.999426206431739 0.999874251669172 0.2 0.0252107263268333 0.556095462307641 0.166666666666666 0.00421074451448947 0.641234578997674 0.111111111111111 0.00280913674659921 0.482496514917337 0.263481097677988 0.00557488767977023 2.35495138024288 0.244962320354816 416 5574 False False 0.329351372097486 0.0340635477373695 1.6506834450398 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 0.99970875200233 0.999426206431739 0.999874251669172 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4241 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Met312Val Rv2752c_p.Met312Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 15 0 15 1 15 20845 27453 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999453910004368 0.999099467294252 0.999694326386446 0.0625 0.00158111172276588 0.302320738434531 0 0 0.218019360910534 0 0 0.218019360910534 0 0 0.367237417488399 0.000278535844132661 65 5574 True False 0.0878004317582154 0.00208981885650849 0.570795388928157 0 0 0.000176951454458875 0.999453910004368 0.999099467294252 0.999694326386446 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 15 0 15 0 15 13374 21298 0 0 0.000275786657608973 0.999296204194623 0.998839461100611 0.999606039023746 0 0 0.218019360910534 0 0 0.218019360910534 0 0 0.218019360910534 0 0 0.444098942662297 0.000850248697602681 53 4479 False False 0 0 0 0 0 0 0 0 0 0.444098942662297 0 0 0.000275786657608973 0.999296204194623 0.998839461100611 0.999606039023746 2 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Met318_Arg320del Rv2752c_p.Met318_Arg320del 2 inframe_deletion (see "Genomic_coordinates" sheet) NA 0 0 0 5 0 20841 27468 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 1 0.999865711673152 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 5163 5574 False False Inf 1.20760984683633 Inf 0 0 0.000176985413634466 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4155 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Met31fs Rv2752c_p.Met31fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5383 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4329 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Met31Ile Rv2752c_p.Met31Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 97 263 20749 27205 0.00465317087210975 0.00377497977748854 0.00567356718829501 0.990425222076598 0.989202012948825 0.991542936197213 0.269444444444444 0.224286455910998 0.318440532754478 NA NA NA 0 0 0.0139282493648346 NA NA NA NA NA NA False True 0.483579125257216 0.37882858183358 0.613067047133052 0 0 0.000177770088109574 0.990425222076598 0.989202012948825 0.991542936197213 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 52 140 13322 21173 0.00388814116943322 0.00290517208380311 0.00509569182719799 0.993431239149814 0.992253193662817 0.994471480123505 0.270833333333333 0.209360859160925 0.339529966766327 NA NA NA 0 0 0.0260050293512926 NA NA NA NA NA NA False True 0 0 0 0 0 1 0 0.590321058614107 0.420564028239716 0.81772702090033 0 0 0.0002768629915513 0.993431239149814 0.992253193662817 0.994471480123505 17 Not assoc w R Previous WHO guidance 4) Not assoc w R - Interim DOWN from NotAwR to NotAwRI yes Prev. WHO 3 +Isoniazid Rv2752c p.Met394Arg Rv2752c_p.Met394Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 5219 5574 False False Inf 0.869878292971449 Inf 0 0 0.000176976922618654 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 13370 21313 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 1 0.999826933785262 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 4204 4479 False False 0 0 0 0 0 0 0 Inf 1.05210128917758 Inf 0 0 0.000275869155324334 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Met394fs Rv2752c_p.Met394fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5321 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4283 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Met394Thr Rv2752c_p.Met394Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Met447Thr Rv2752c_p.Met447Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 2 20843 27466 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999927188000582 0.999737003036386 0.999991182007438 0.6 0.146632799634673 0.947255049473683 0 0 0.975 0 0 0.841886116991581 0 0 51.3539402930048 1 2027.5 5574 False False 1.97663484143357 0.226402568392661 23.6672561646805 0 0 0.00017696843241753 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 62.0933648450895 1 1642.5 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 2 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Met550dup Rv2752c_p.Met550dup 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5279 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4251 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Met64Arg Rv2752c_p.Met64Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Met64Ile Rv2752c_p.Met64Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Phe107Pro Rv2752c_p.Phe107Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5429 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4363 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Phe107Ser Rv2752c_p.Phe107Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5504 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4422 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Phe107Val Rv2752c_p.Phe107Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 5305 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4273 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Phe125Leu Rv2752c_p.Phe125Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5374 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4321 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Phe139fs Rv2752c_p.Phe139fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Phe139Leu Rv2752c_p.Phe139Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Phe139Val Rv2752c_p.Phe139Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Phe144dup Rv2752c_p.Phe144dup 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Phe144Ser Rv2752c_p.Phe144Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5322 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4284 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Phe238Ser Rv2752c_p.Phe238Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 4 1 20842 27467 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999963594000291 0.999797175631493 0.999999078280314 0.8 0.28358206388191 0.994949236620532 0 0 0.975 0 0 0.975 0 0 51.3582705287504 1 2027.5 5574 False False 5.27147106803569 0.521589398427432 259.279173455301 0 0 0.000176976922618654 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4343 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Phe349fs Rv2752c_p.Phe349fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5485 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Phe34fs Rv2752c_p.Phe34fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5220 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4205 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Phe383Leu Rv2752c_p.Phe383Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Phe383Val Rv2752c_p.Phe383Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5505 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4423 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Phe448Leu Rv2752c_p.Phe448Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5210 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Phe472fs Rv2752c_p.Phe472fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5289 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Phe497Cys Rv2752c_p.Phe497Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5280 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Phe49Leu Rv2752c_p.Phe49Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5544 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4455 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Pro101Ala Rv2752c_p.Pro101Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 10 0 10 1 23 20845 27445 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999162662006698 0.998743845166008 0.999469127824854 0.0416666666666666 0.00105435244546974 0.211201683456973 0 0 0.30849710781876 0 0 0.148185128915224 0 0 0.587475574946681 0.00669301266525492 110 5574 False False 0.0572444648388206 0.00139393050307766 0.352593694589121 0 0 0.000176951454458875 0.999162662006698 0.998743845166008 0.999469127824854 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 1 18 13373 21295 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999155445033547 0.998665566208554 0.999499388823668 0.0526315789473684 0.00133162880417942 0.260280654195214 0 0 0.30849710781876 0 0 0.185301968137852 0 0 0.710552066585083 0.00888432553356907 72 4479 False False 0 0 0 0 0 0 0 0.0884659803750508 0.00212733930226502 0.560429293726884 0 0 0.000275807277411719 0.999155445033547 0.998665566208554 0.999499388823668 1 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Pro101Leu Rv2752c_p.Pro101Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5486 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4405 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Pro10Arg Rv2752c_p.Pro10Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5323 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4285 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Pro123Ala Rv2752c_p.Pro123Ala 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5211 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4196 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Pro123Leu Rv2752c_p.Pro123Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 177 227 20669 27241 0.00849083757075698 0.00729022993431017 0.00983136861440314 0.991735838066113 0.990593357513033 0.992772380464037 0.438118811881188 0.389108911647519 0.488041733208367 NA NA NA 0 0 0.0161192421133921 NA NA NA NA NA NA False True 1.02766363809002 0.838757122953921 1.25746216491375 0 0 0.000178458091302422 0.991735838066113 0.990593357513033 0.992772380464037 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 100 175 13274 21138 0.00747719455660236 0.00608776467976969 0.00908690953839941 0.991789048937268 0.990484564734563 0.992956579011225 0.363636363636363 0.306708189433439 0.423538663676486 NA NA NA 0 0 0.0208586953490573 NA NA NA NA NA NA False True 0 0 0 0 0 1 0 0.909963623840375 0.703789852507067 1.17116532420318 0 0 0.000277864014385219 0.991789048937268 0.990484564734563 0.992956579011225 85 Not assoc w R Previous WHO guidance 4) Not assoc w R - Interim DOWN from NotAwR to NotAwRI yes Prev. WHO 3 +Isoniazid Rv2752c p.Pro123Ser Rv2752c_p.Pro123Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5545 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4456 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Pro178Leu Rv2752c_p.Pro178Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5487 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4406 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Pro182Leu Rv2752c_p.Pro182Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5234 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Pro186Ser Rv2752c_p.Pro186Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 5256 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4232 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Pro209Ala Rv2752c_p.Pro209Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Pro209Ser Rv2752c_p.Pro209Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Pro213Ala Rv2752c_p.Pro213Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Pro213fs Rv2752c_p.Pro213fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Pro213Leu Rv2752c_p.Pro213Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5518 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4435 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Pro220Ala Rv2752c_p.Pro220Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5164 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4156 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Pro220fs Rv2752c_p.Pro220fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 4 1 20842 27467 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999963594000291 0.999797175631493 0.999999078280314 0.8 0.28358206388191 0.994949236620532 0 0 0.975 0 0 0.975 0 0 51.3582705287504 1 2027.5 5574 False False 5.27147106803569 0.521589398427432 259.279173455301 0 0 0.000176976922618654 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 4 1 13370 21312 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 0.999953080279641 0.999738608085756 0.999998812096234 0.8 0.28358206388191 0.994949236620532 0 0 0.975 0 0 0.975 0 0 62.1101953816142 1 1642.5 4479 False False 0 0 0 0 0 0 0 6.37606581899775 0.630846560224411 313.513380938872 0 0 0.000275869155324334 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Pro220Leu Rv2752c_p.Pro220Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Pro390Arg Rv2752c_p.Pro390Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5401 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Pro390Leu Rv2752c_p.Pro390Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 104 3 20742 27465 0.00498896670824138 0.00407811239997398 0.00604177370329819 0.999890782000873 0.99968085216583 0.999977476056514 0.97196261682243 0.920245344167596 0.994180271208493 NA NA NA 0 0 0.707598226178713 NA NA NA NA 5128 5574 False False 45.9029987465046 15.2800030573502 225.786769598284 0 0 0.000177830076537168 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 75 2 13299 21311 0.00560789591745177 0.00441344529642578 0.00702454490997594 0.999906160559283 0.999661061221376 0.999988635406343 0.974025974025974 0.909302844894659 0.996838799699984 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4124 4479 False False 0 0 0 0 0 0 0 60.0919242048274 16.0556639022484 504.655860978175 0 0 0.000277341746772667 0.999906160559283 0.999661061221376 0.999988635406343 12 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Pro395Ser Rv2752c_p.Pro395Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5527 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4443 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Pro416Leu Rv2752c_p.Pro416Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Pro443Leu Rv2752c_p.Pro443Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 7 20846 27461 0 0 0.00017694296670111 0.999745158002038 0.999474999027776 0.999897534357495 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.914121240039481 0.0219749245408003 156 5574 False False 0 0 0.914121240039481 0 0 0.00017694296670111 0.999745158002038 0.999474999027776 0.999897534357495 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 13374 21308 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.73894646374006 0.163960020972012 248.5 4479 False False 0 0 0 0 0 0 0 0 0 1.73894646374006 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Pro486Leu Rv2752c_p.Pro486Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Pro490Arg Rv2752c_p.Pro490Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 5488 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4407 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Pro490fs Rv2752c_p.Pro490fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5430 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4364 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Pro50Leu Rv2752c_p.Pro50Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Pro526Arg Rv2752c_p.Pro526Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5474 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Pro549Gln Rv2752c_p.Pro549Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Pro549Leu Rv2752c_p.Pro549Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Pro549Ser Rv2752c_p.Pro549Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Pro553Leu Rv2752c_p.Pro553Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Pro553Ser Rv2752c_p.Pro553Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 1 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Pro55Ser Rv2752c_p.Pro55Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5454 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4379 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Pro62Leu Rv2752c_p.Pro62Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5338 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Pro62Ser Rv2752c_p.Pro62Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Pro62Thr Rv2752c_p.Pro62Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5221 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4206 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Pro6Arg Rv2752c_p.Pro6Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Pro6fs Rv2752c_p.Pro6fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 5559 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4467 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Pro7fs Rv2752c_p.Pro7fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 5385 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4331 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Pro7Gln Rv2752c_p.Pro7Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5384 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4330 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Pro8fs Rv2752c_p.Pro8fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01632529799099 0.509386028876591 1135.5 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Pro8Ser Rv2752c_p.Pro8Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Pro91Leu Rv2752c_p.Pro91Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 93 9 20753 27459 0.00446128753717739 0.00360229970804138 0.00546263271662529 0.999672346002621 0.99937810218515 0.999850165132458 0.911764705882352 0.839101807743713 0.958856168622281 0 0 0.975 0 0 0.336267116879942 0 0 51.563334861264 1 2027.5 5574 False False 13.6723847154628 6.89895900414813 30.8402574022066 0 0 0.000177735827175903 0.999672346002621 0.99937810218515 0.999850165132458 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 77 7 13297 21306 0.00575743980858381 0.00454627388994599 0.00719063205927938 0.99967156195749 0.999323409938814 0.999867941002665 0.916666666666666 0.835810919729204 0.965837622146033 NA NA NA 0 0 0.409616397225003 NA NA NA NA 4260 4479 False False 0 0 0 0 0 0 0 17.6254794314507 8.15257751140088 45.2770113526945 0 0 0.000277383455921829 0.99967156195749 0.999323409938814 0.999867941002665 1 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ser133fs Rv2752c_p.Ser133fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5431 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ser13Tyr Rv2752c_p.Ser13Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ser149Phe Rv2752c_p.Ser149Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 5 1 20841 27467 0.000239854168665451 7.78844354195375e-05 0.000559650096554077 0.999963594000291 0.999797175631493 0.999999078280314 0.833333333333333 0.358765421002325 0.99578925548551 0 0 0.975 0 0 0.975 0 0 51.360732841256 1 2027.5 5574 False False 6.58965500695744 0.737267067818355 311.215258952954 0 0 0.000176985413634466 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ser189* Rv2752c_p.Ser189* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5143 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4137 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ser216fs Rv2752c_p.Ser216fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5235 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4214 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ser240Cys Rv2752c_p.Ser240Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ser240fs Rv2752c_p.Ser240fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5432 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ser240Phe Rv2752c_p.Ser240Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 5 20845 27463 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999817970001456 0.999575254267103 0.999940892797913 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.707598226178713 0 0 0.521823750104981 0 0 3.18857396131196 0.264071697777887 449 5574 False False 0.263497241544735 0.00557522895465965 2.35509564487831 0 0 0.000176951454458875 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 4 13373 21309 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999812321118566 0.999519537882235 0.999948861529775 0.2 0.00505076337946806 0.716417936118089 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.85662582934577 0.289271991675179 380.5 4479 False False 0 0 0 0 0 0 0 0.398358633066626 0.00809276091420046 4.02622197901862 0 0 0.000275807277411719 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ser240Pro Rv2752c_p.Ser240Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5144 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4138 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ser260* Rv2752c_p.Ser260* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5290 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4261 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ser284fs Rv2752c_p.Ser284fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ser284Pro Rv2752c_p.Ser284Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 5402 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4344 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ser313Leu Rv2752c_p.Ser313Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 5528 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4444 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ser313Pro Rv2752c_p.Ser313Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5375 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ser313Trp Rv2752c_p.Ser313Trp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5455 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ser316Leu Rv2752c_p.Ser316Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ser319Leu Rv2752c_p.Ser319Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ser319Pro Rv2752c_p.Ser319Pro 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 5291 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4262 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ser325Arg Rv2752c_p.Ser325Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ser337Leu Rv2752c_p.Ser337Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 3 1 20843 27467 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 0.999963594000291 0.999797175631493 0.999999078280314 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 5447 5574 False False 3.95341361608213 0.31739219148065 207.323829234655 0 0 0.00017696843241753 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4376 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ser337Pro Rv2752c_p.Ser337Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4380 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ser337Trp Rv2752c_p.Ser337Trp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5222 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ser338Leu Rv2752c_p.Ser338Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5448 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ser338Pro Rv2752c_p.Ser338Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5519 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4436 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ser339del Rv2752c_p.Ser339del 2 inframe_deletion (see "Genomic_coordinates" sheet) NA 0 0 0 10 0 20836 27468 0.000479708337330902 0.000230061997553563 0.000882023176671562 1 0.999865711673152 1 1 0.691502892181239 1 NA NA NA NA NA NA NA NA NA NA 5166 5574 False False Inf 2.95450432812812 Inf 0 0 0.000177027880937939 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 9 0 13365 21313 0.000672947510094212 0.000307759154923187 0.00127707788784856 1 0.999826933785262 1 1 0.663732883120057 1 NA NA NA NA NA NA NA NA NA NA 4158 4479 False False 0 0 0 0 0 0 0 Inf 3.14671336895126 Inf 0 0 0.000275972346901473 1 0.999826933785262 1 2 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ser339Pro Rv2752c_p.Ser339Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5165 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4157 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ser339* Rv2752c_p.Ser339* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5546 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4457 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ser356Cys Rv2752c_p.Ser356Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 5245 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4222 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ser356Pro Rv2752c_p.Ser356Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 12 0 20834 27468 0.000575650004797083 0.000297481006307132 0.00100532857413147 1 0.999865711673152 1 1 0.735351530602948 1 1 0.025 1 1 0.025 1 Inf 0.0338037952176352 Inf 0.431339668343581 596 5574 False False Inf 3.66300284077067 Inf 4.79961603071754e-05 1.2151568323366e-06 0.000267388152660504 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 9 0 13365 21313 0.000672947510094212 0.000307759154923187 0.00127707788784856 1 0.999826933785262 1 1 0.663732883120057 1 1 0.025 1 1 0.025 1 Inf 0.0408861471467416 Inf 0.385420571527437 477 4479 False False 0 0 0 0 0 0 0 Inf 3.14671336895126 Inf 7.48166990872362e-05 1.89419302752316e-06 0.000416780684952488 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ser373Phe Rv2752c_p.Ser373Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5236 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4215 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ser373Tyr Rv2752c_p.Ser373Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5292 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4263 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ser412Arg Rv2752c_p.Ser412Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ser419* Rv2752c_p.Ser419* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ser428Gly Rv2752c_p.Ser428Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ser437Gly Rv2752c_p.Ser437Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 20845 27465 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999890782000873 0.99968085216583 0.999977476056514 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18880616510555 0.264079043314886 541.5 5574 False False 0.439194051331254 0.00837049629364692 5.4704842261679 0 0 0.000176951454458875 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 3 13373 21310 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999859240838924 0.999588697652472 0.999970971136275 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85680682534852 0.289279625558287 389.5 4479 False False 0 0 0 0 0 0 0 0.531169769934445 0.010122018243966 6.61631049307563 0 0 0.000275807277411719 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ser439Cys Rv2752c_p.Ser439Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5306 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4274 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ser439Phe Rv2752c_p.Ser439Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 4 3 20842 27465 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999890782000873 0.99968085216583 0.999977476056514 0.571428571428571 0.184051567640083 0.901011721557492 0 0 0.841886116991581 0 0 0.707598226178713 0 0 7.01707977037795 0.509393260941204 1185 5574 False False 1.75702907590442 0.297192930207644 11.9979296337129 0 0 0.000176976922618654 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 13370 21313 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 1 0.999826933785262 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 4125 4479 False False 0 0 0 0 0 0 0 Inf 1.05210128917758 Inf 0 0 0.000275869155324334 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ser439Pro Rv2752c_p.Ser439Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5266 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4242 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ser470Leu Rv2752c_p.Ser470Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 2 4 20844 27464 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999854376001165 0.999627187086024 0.999960320981843 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.602364635616474 0 0 0.602364635616474 0 0 1.99623938970482 0.139127771476516 349 5574 False False 0.658798695068125 0.0595601499680727 4.59736120623929 0 0 0.000176959943030976 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 2 3 13372 21310 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999859240838924 0.999588697652472 0.999970971136275 0.4 0.0527449505263169 0.853367200365326 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85709530412199 0.289291791934617 400.5 4479 False False 0 0 0 0 0 0 0 1.06241898494366 0.0886985485353837 9.27715037564111 0 0 0.000275827900298067 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ser470Pro Rv2752c_p.Ser470Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5339 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4297 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ser494Leu Rv2752c_p.Ser494Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5529 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4445 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ser494Pro Rv2752c_p.Ser494Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 5386 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4332 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ser498Ala Rv2752c_p.Ser498Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5456 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4381 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Ser498fs Rv2752c_p.Ser498fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5212 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4197 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ser498Pro Rv2752c_p.Ser498Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 32 0 20814 27468 0.00153506667945888 0.00105021407755197 0.00216637124602793 1 0.999865711673152 1 1 0.891118839320647 1 1 0.025 1 1 0.025 1 Inf 0.0338362759797656 Inf 0.431104115320092 592 5574 False False Inf 10.7991034929091 Inf 4.80422772039394e-05 1.21632440965423e-06 0.000267645043162176 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 11 0 13363 21313 0.000822491401226259 0.000410653977896139 0.00147118664271154 1 0.999826933785262 1 1 0.715085847081845 1 1 0.025 1 1 0.025 1 Inf 0.0408922660640232 Inf 0.385385125587565 475 4479 False False 0 0 0 0 0 0 0 Inf 4.00162721599209 Inf 7.4827895839569e-05 1.89447650421177e-06 0.000416843047927529 1 0.999826933785262 1 6 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ter559Glnext*? Rv2752c_p.Ter559Glnext*? 2 stop_lost (see "Genomic_coordinates" sheet) 0 0 0 0 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 5340 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4298 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Ter559Tyrext*? Rv2752c_p.Ter559Tyrext*? 2 stop_lost (see "Genomic_coordinates" sheet) NA 0 0 0 10 0 20836 27468 0.000479708337330902 0.000230061997553563 0.000882023176671562 1 0.999865711673152 1 1 0.691502892181239 1 NA NA NA NA NA NA NA NA NA NA 5185 5574 False False Inf 2.95450432812812 Inf 0 0 0.000177027880937939 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 9 0 13365 21313 0.000672947510094212 0.000307759154923187 0.00127707788784856 1 0.999826933785262 1 1 0.663732883120057 1 NA NA NA NA NA NA NA NA NA NA 4177 4479 False False 0 0 0 0 0 0 0 Inf 3.14671336895126 Inf 0 0 0.000275972346901473 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Thr122Ile Rv2752c_p.Thr122Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Thr12Ala Rv2752c_p.Thr12Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Thr134Ser Rv2752c_p.Thr134Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5573 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4478 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Thr150Pro Rv2752c_p.Thr150Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5246 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4223 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Thr160Asn Rv2752c_p.Thr160Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5293 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4264 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Thr160Ile Rv2752c_p.Thr160Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Thr160Pro Rv2752c_p.Thr160Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Thr164fs Rv2752c_p.Thr164fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5267 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4243 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Thr183Ile Rv2752c_p.Thr183Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 5341 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4299 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Thr183Pro Rv2752c_p.Thr183Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5354 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4307 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Thr204Ala Rv2752c_p.Thr204Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Thr204Arg Rv2752c_p.Thr204Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5324 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4286 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Thr221Ala Rv2752c_p.Thr221Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Thr305Asn Rv2752c_p.Thr305Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5412 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4349 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Thr307Ala Rv2752c_p.Thr307Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5413 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4350 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Thr307Pro Rv2752c_p.Thr307Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 5129 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4126 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Thr329Ala Rv2752c_p.Thr329Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5167 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4159 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Thr329Pro Rv2752c_p.Thr329Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 1 4 4 6 20842 27462 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999781564001747 0.999524617886493 0.999919833755107 0.4 0.121552258119827 0.737621923393055 0.2 0.00505076337946806 0.716417936118089 0.142857142857142 0.00361029686190058 0.578723197043195 0.329406966701852 0.00669307666258536 3.329130357986 0.398249597496107 582 5574 False False 0.878418577871605 0.182308638457443 3.70497296035774 4.79777383294151e-05 1.21469042880762e-06 0.000267285534484979 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 3 5 13371 21308 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999765401398207 0.999452610763328 0.999923822225278 0.375 0.0852334141372535 0.755136783633448 0 0 0.602364635616474 0 0 0.521823750104981 0 0 2.41463279756315 0.305466089052991 425 4479 False False 0 0 0 0 0 0 0 0.956158851245232 0.148446407940978 4.91535926753262 0 0 0.000275848526268708 0.999765401398207 0.999452610763328 0.999923822225278 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Thr32Arg Rv2752c_p.Thr32Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5145 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Thr364Ile Rv2752c_p.Thr364Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 5530 5574 False False Inf 0.869878292971449 Inf 0 0 0.000176976922618654 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Thr364Pro Rv2752c_p.Thr364Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 51.3446878573018 1 2027.5 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4252 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Thr399Ile Rv2752c_p.Thr399Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5325 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Thr413Ile Rv2752c_p.Thr413Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Thr461Ile Rv2752c_p.Thr461Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 2 4 20844 27464 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999854376001165 0.999627187086024 0.999960320981843 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.841886116991581 0 0 0.602364635616474 0 0 7.01615100815696 0.509384357655263 1115 5574 False False 0.658798695068125 0.0595601499680727 4.59736120623929 0 0 0.000176959943030976 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 3 13372 21310 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999859240838924 0.999588697652472 0.999970971136275 0.4 0.0527449505263169 0.853367200365326 0 0 0.975 0 0 0.707598226178713 0 0 62.0950929450045 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.06241898494366 0.0886985485353837 9.27715037564111 0 0 0.000275827900298067 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Thr461Pro Rv2752c_p.Thr461Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5387 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Thr461Ser Rv2752c_p.Thr461Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Thr476fs Rv2752c_p.Thr476fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5281 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Thr476Pro Rv2752c_p.Thr476Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 5355 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4308 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Thr536Met Rv2752c_p.Thr536Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Thr536Ser Rv2752c_p.Thr536Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 3.18842099130276 0.264066860104113 431 5574 False False 0 0 1.43785249906968 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.48495357236853 0.526173219289417 690 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Thr544fs Rv2752c_p.Thr544fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 51.3533466119536 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 13372 21312 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999953080279641 0.999738608085756 0.999998812096234 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 62.1009148060541 1 1642.5 4479 False False 0 0 0 0 0 0 0 3.18755608734669 0.165916091907768 187.852707212672 0 0 0.000275827900298067 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Thr554Pro Rv2752c_p.Thr554Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5268 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Thr80Ala Rv2752c_p.Thr80Ala 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 5 20845 27463 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999817970001456 0.999575254267103 0.999940892797913 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA 0 0 0.521823750104981 NA NA NA NA 5433 5574 False False 0.263497241544735 0.00557522895465965 2.35509564487831 0 0 0.000176951454458875 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4365 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Thr80Ile Rv2752c_p.Thr80Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 10 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Trp400Arg Rv2752c_p.Trp400Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Trp400* Rv2752c_p.Trp400* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 16 2 20830 27466 0.000767533339729444 0.000438773245501675 0.00124612759964746 0.999927188000582 0.999737003036386 0.999991182007438 0.888888888888888 0.652879561391328 0.986248784335635 0 0 0.975 0 0 0.841886116991581 0 0 51.3859645466286 1 2027.5 5574 False False 10.5486317810849 2.47949889584338 94.5961284728182 0 0 0.000177078868611313 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 10 2 13364 21311 0.000747719455660236 0.000358616922835118 0.00137465137870696 0.999906160559283 0.999661061221376 0.999988635406343 0.833333333333333 0.515862251314033 0.979137474539907 0 0 0.975 0 0 0.841886116991581 0 0 62.1351410892563 1 1642.5 4479 False False 0 0 0 0 0 0 0 7.97328644118527 1.6986053949928 74.7300869626313 0 0 0.000275992994481552 0.999906160559283 0.999661061221376 0.999988635406343 9 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Trp540Arg Rv2752c_p.Trp540Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 5247 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4224 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Trp540fs Rv2752c_p.Trp540fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5237 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4216 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Trp540Gly Rv2752c_p.Trp540Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5356 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4309 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Trp540* Rv2752c_p.Trp540* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 5257 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Tyr143Cys Rv2752c_p.Tyr143Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 20845 27467 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999963594000291 0.999797175631493 0.999999078280314 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 51.3508850075945 1 2027.5 5574 False False 1.31767810026385 0.0167927522337569 103.35711725526 0 0 0.000176951454458875 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Tyr143* Rv2752c_p.Tyr143* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5506 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Tyr159fs Rv2752c_p.Tyr159fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5357 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4310 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Tyr159* Rv2752c_p.Tyr159* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Tyr377Asp Rv2752c_p.Tyr377Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5403 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4345 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Tyr385Asp Rv2752c_p.Tyr385Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 8 1 20838 27467 0.000383766669864722 0.000165697303700768 0.000756032532322191 0.999963594000291 0.999797175631493 0.999999078280314 0.888888888888888 0.517503485082663 0.9971908632534 0 0 0.975 0 0 0.975 0 0 51.3681211956089 1 2027.5 5574 False False 10.5449659276322 1.4135292589455 466.907166500354 0 0 0.000177010891571197 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 5 0 13369 21313 0.000373859727830118 0.000121402023062639 0.000872246401868143 1 0.999826933785262 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 4287 4479 False False 0 0 0 0 0 0 0 Inf 1.46057233596553 Inf 0 0 0.000275889787465637 1 0.999826933785262 1 6 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Tyr545Cys Rv2752c_p.Tyr545Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 5414 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4351 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Val102Ala Rv2752c_p.Val102Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 2 20845 27466 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999927188000582 0.999737003036386 0.999991182007438 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 5475 5574 False False 0.658815063564403 0.011171855707321 12.6567401482543 0 0 0.000176951454458875 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 2 13373 21311 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999906160559283 0.999661061221376 0.999988635406343 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4396 4479 False False 0 0 0 0 0 0 0 0.796792043670081 0.0135099696349484 15.307558728263 0 0 0.000275807277411719 0.999906160559283 0.999661061221376 0.999988635406343 1 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Val102Ile Rv2752c_p.Val102Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5342 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4300 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Val103Asp Rv2752c_p.Val103Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5130 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4127 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Val112_Ala113del Rv2752c_p.Val112_Ala113del 2 inframe_deletion (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5415 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4352 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Val112Ile Rv2752c_p.Val112Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Val124Met Rv2752c_p.Val124Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5547 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4458 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Val128Gly Rv2752c_p.Val128Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 5223 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4207 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Val138Ala Rv2752c_p.Val138Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5449 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Val138Leu Rv2752c_p.Val138Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 20846 27465 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.18865318395302 0.264074204428198 489 5574 False False 0 0 3.18865318395302 0 0 0.00017694296670111 0.999890782000873 0.99968085216583 0.999977476056514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Val146dup Rv2752c_p.Val146dup 2 inframe_insertion (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5186 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Val146fs Rv2752c_p.Val146fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 16 0 20830 27468 0.000767533339729444 0.000438773245501675 0.00124612759964746 1 0.999865711673152 1 1 0.794092785792177 1 NA NA NA NA NA NA NA NA NA NA 5457 5574 False False Inf 5.0841332374657 Inf 0 0 0.000177078868611313 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4382 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Val146Leu Rv2752c_p.Val146Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 20846 27462 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.11900921779861 0.0402109359097128 194.5 5574 False False 0 0 1.11900921779861 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 13374 21307 0 0 0.000275786657608973 0.999718481677849 0.999387354605726 0.999896680954833 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.35335561005417 0.0884814409570568 164 4479 False False 0 0 0 0 0 0 0 0 0 1.35335561005417 0 0 0.000275786657608973 0.999718481677849 0.999387354605726 0.999896680954833 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Val196Ala Rv2752c_p.Val196Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 20846 27464 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 5476 5574 False False 0 0 1.99604811372315 0 0 0.00017694296670111 0.999854376001165 0.999627187086024 0.999960320981843 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 13374 21309 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4397 4479 False False 0 0 0 0 0 0 0 0 0 2.41420404242617 0 0 0.000275786657608973 0.999812321118566 0.999519537882235 0.999948861529775 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Val211Ala Rv2752c_p.Val211Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5193 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4183 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Val211Ile Rv2752c_p.Val211Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5168 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4160 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Val211Leu Rv2752c_p.Val211Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Val218Leu Rv2752c_p.Val218Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 10 1 9 4 11 20842 27457 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999599534003203 0.9992835689522 0.999800072407065 0.266666666666666 0.0778715462910436 0.551003241036971 0.1 0.00252857854446178 0.445016117028195 0.0833333333333333 0.00210759323186022 0.384796165150944 0.146376440733988 0.00334368423068041 1.05652511354453 0.0509232641521047 225 5574 False False 0.479050169674869 0.111232291522201 1.6169999684461 4.79777383294151e-05 1.21469042880762e-06 0.000267285534484979 0.999599534003203 0.9992835689522 0.999800072407065 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 2 6 13372 21307 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 0.999718481677849 0.999387354605726 0.999896680954833 0.25 0.0318540262499442 0.650855794412824 0 0 0.602364635616474 0 0 0.4592581264399 0 0 2.41433866049165 0.305470933327882 430 4479 False False 0 0 0 0 0 0 0 0.531134709342905 0.0524216694068566 2.97088164447145 0 0 0.000275827900298067 0.999718481677849 0.999387354605726 0.999896680954833 1 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Val233Gly Rv2752c_p.Val233Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 5146 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 13371 21313 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 1 0.999826933785262 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4139 4479 False False 0 0 0 0 0 0 0 Inf 0.65857349539183 Inf 0 0 0.000275848526268708 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Val233Met Rv2752c_p.Val233Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Val242Met Rv2752c_p.Val242Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Val245Ile Rv2752c_p.Val245Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 20846 27462 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.11900921779861 0.0402109359097128 194.5 5574 False False 0 0 1.11900921779861 0 0 0.00017694296670111 0.999781564001747 0.999524617886493 0.999919833755107 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 13374 21310 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.85651838973546 0.289267461766355 341 4479 False False 0 0 0 0 0 0 0 0 0 3.85651838973546 0 0 0.000275786657608973 0.999859240838924 0.999588697652472 0.999970971136275 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Val245Leu Rv2752c_p.Val245Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5248 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4225 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Val259Ala Rv2752c_p.Val259Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Val272Ala Rv2752c_p.Val272Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 10 10 20836 27458 0.000479708337330902 0.000230061997553563 0.000882023176671562 0.999635940002912 0.999330582956894 0.999825405716755 0.5 0.271957849560791 0.728042150439208 0 0 0.369416647552819 0 0 0.30849710781876 0 0 0.772122853103474 0.0121237678940928 131 5574 False False 1.31781531963908 0.492144336011851 3.52853931771283 0 0 0.000177027880937939 0.999635940002912 0.999330582956894 0.999825405716755 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 3 10 13371 21303 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999530802796415 0.99913729947772 0.999774979505452 0.23076923076923 0.0503810734911515 0.53813153923404 0 0 0.369416647552819 0 0 0.30849710781876 0 0 0.933561749220533 0.0270189675861353 123 4479 False False 0 0 0 0 0 0 0 0.477967242539825 0.0845118861353376 1.85677244072755 0 0 0.000275848526268708 0.999530802796415 0.99913729947772 0.999774979505452 1 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Val281Glu Rv2752c_p.Val281Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Val300Ala Rv2752c_p.Val300Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 128 83 20718 27385 0.00614026671783555 0.00512516568021584 0.00729655610021751 0.996978302024173 0.996255507672953 0.99759253756384 0.606635071090047 0.537231741704836 0.672997454240161 NA NA NA 0 0 0.0434711521664418 NA NA NA NA NA NA False True 2.03843465376129 1.53349306230124 2.72201587738729 0 0 0.000178036058866175 0.996978302024173 0.996255507672953 0.99759253756384 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 108 68 13266 21245 0.00807537012113055 0.00662895250643954 0.00974154295269258 0.996809459015624 0.995956957474106 0.997521594135048 0.613636363636363 0.537436045089057 0.685940444774179 NA NA NA 0 0 0.0528030427936397 NA NA NA NA NA NA False True 0 0 0 0 0 1 0 2.54349908212946 1.85907148943186 3.50047096309424 0 0 0.000278031555698848 0.996809459015624 0.995956957474106 0.997521594135048 4 Not assoc w R Previous WHO guidance 4) Not assoc w R - Interim DOWN from NotAwR to NotAwRI yes Prev. WHO 3 +Isoniazid Rv2752c p.Val335Met Rv2752c_p.Val335Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.43785249906968 0.0743380732312645 251 5574 False False 0 0 1.43785249906968 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Val348fs Rv2752c_p.Val348fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 70 0 20776 27468 0.00335795836131631 0.00261860038191089 0.00424070087457446 1 0.999865711673152 1 1 0.948666202848976 1 NA NA NA NA NA NA NA NA NA NA 5169 5574 False False Inf 24.4239103652078 Inf 0 0 0.000177539082801605 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 70 0 13304 21313 0.00523403618962165 0.00408239317425268 0.00660832707955059 1 0.999826933785262 1 1 0.948666202848976 1 NA NA NA NA NA NA NA NA NA NA 4161 4479 False False 0 0 0 0 0 0 0 Inf 29.5992071454318 Inf 0 0 0.000277237528756112 1 0.999826933785262 1 2 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Val351Ala Rv2752c_p.Val351Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 15 20846 27453 0 0 0.00017694296670111 0.999453910004368 0.999099467294252 0.999694326386446 0 0 0.218019360910534 0 0 0.602364635616474 0 0 0.218019360910534 0 0 1.99524976370881 0.13907740292012 296 5574 False False 0 0 0.367219809598921 0 0 0.00017694296670111 0.999453910004368 0.999099467294252 0.999694326386446 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 10 13374 21303 0 0 0.000275786657608973 0.999530802796415 0.99913729947772 0.999774979505452 0 0 0.30849710781876 0 0 0.602364635616474 0 0 0.30849710781876 0 0 2.41352375807041 0.305484393035155 468.5 4479 False False 0 0 0 0 0 0 0 0 0 0.710765762832934 0 0 0.000275786657608973 0.999530802796415 0.99913729947772 0.999774979505452 1 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Val370Gly Rv2752c_p.Val370Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0337875782094303 Inf 0.431457371721896 645 5574 False False Inf 0.247471899512553 Inf 4.79731350443751e-05 1.21457388386244e-06 0.000267259892247036 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.040864745349235 Inf 0.385544600126852 512 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 7.47775368279368e-05 1.89320152683959e-06 0.000416562561410248 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Val372fs Rv2752c_p.Val372fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 5477 5574 False False Inf 0.869878292971449 Inf 0 0 0.000176976922618654 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 13370 21313 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 1 0.999826933785262 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 4398 4479 False False 0 0 0 0 0 0 0 Inf 1.05210128917758 Inf 0 0 0.000275869155324334 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Val388fs Rv2752c_p.Val388fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5294 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Val388Glu Rv2752c_p.Val388Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5224 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4208 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Val393Met Rv2752c_p.Val393Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Val396Gly Rv2752c_p.Val396Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 51.3465557483136 1 2027.5 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 62.0887265075828 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 1 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Val415Ala Rv2752c_p.Val415Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Val415Gly Rv2752c_p.Val415Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5458 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4383 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Val415Ile Rv2752c_p.Val415Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5258 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4233 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Val429Phe Rv2752c_p.Val429Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Val432fs Rv2752c_p.Val432fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5388 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Val457Ile Rv2752c_p.Val457Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Val473Ala Rv2752c_p.Val473Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5489 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4408 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Val473Gly Rv2752c_p.Val473Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5170 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4162 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Val475Ala Rv2752c_p.Val475Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5389 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4333 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Val477Ile Rv2752c_p.Val477Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 1 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Val47Ala Rv2752c_p.Val47Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Val47fs Rv2752c_p.Val47fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5194 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4184 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Val47Met Rv2752c_p.Val47Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5574 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4479 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Val511fs Rv2752c_p.Val511fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5148 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4141 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Val511Gly Rv2752c_p.Val511Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 5147 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4140 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Val523Phe Rv2752c_p.Val523Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5295 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4265 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Val533Ala Rv2752c_p.Val533Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.43785249906968 0.0743380732312645 251 5574 False False 0 0 1.43785249906968 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 13374 21308 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.73894646374006 0.163960020972012 248.5 4479 False False 0 0 0 0 0 0 0 0 0 1.73894646374006 0 0 0.000275786657608973 0.999765401398207 0.999452610763328 0.999923822225278 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Val533fs Rv2752c_p.Val533fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Val533Gly Rv2752c_p.Val533Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 4 1 20842 27467 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 0.999963594000291 0.999797175631493 0.999999078280314 0.8 0.28358206388191 0.994949236620532 0 0 0.975 0 0 0.975 0 0 51.3582705287504 1 2027.5 5574 False False 5.27147106803569 0.521589398427432 259.279173455301 0 0 0.000176976922618654 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 1 13371 21312 0.00022431583669807 4.6261707448018e-05 0.000655404732399905 0.999953080279641 0.999738608085756 0.999998812096234 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 62.1055547471297 1 1642.5 4479 False False 0 0 0 0 0 0 0 4.78169172088849 0.383875689805931 250.696170545132 0 0 0.000275848526268708 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Val537Phe Rv2752c_p.Val537Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 20846 27466 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 7.01598871232251 0.509382802952132 994 5574 False False 0 0 7.01598871232251 0 0 0.00017694296670111 0.999927188000582 0.999737003036386 0.999991182007438 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Val541Gly Rv2752c_p.Val541Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 5296 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4266 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Val552Ala Rv2752c_p.Val552Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Val552Gly Rv2752c_p.Val552Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 20844 27467 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 0.999963594000291 0.999797175631493 0.999999078280314 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 51.3533466119536 1 2027.5 5574 False False 2.63548263289195 0.137183409715989 155.34952410964 0 0 0.000176959943030976 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 13373 21312 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 0.999953080279641 0.999738608085756 0.999998812096234 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 62.0962755582318 1 1642.5 4479 False False 0 0 0 0 0 0 0 1.59365886487699 0.0203005577541163 124.983813232444 0 0 0.000275807277411719 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Val555Ala Rv2752c_p.Val555Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 20843 27468 0.00014391250119927 2.96792008899536e-05 0.000420515224128061 1 0.999865711673152 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 5238 5574 False False Inf 0.544526627735454 Inf 0 0 0.00017696843241753 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4217 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Val555Gly Rv2752c_p.Val555Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 20845 27468 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 1 0.999865711673152 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 5490 5574 False False Inf 0.0337859573643402 Inf 0 0 0.000176951454458875 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 13373 21313 7.47719455660236e-05 1.89305996861207e-06 0.000416531419540481 1 0.999826933785262 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4409 4479 False False 0 0 0 0 0 0 0 Inf 0.0408616897784423 Inf 0 0 0.000275807277411719 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Val555Ile Rv2752c_p.Val555Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Val558fs Rv2752c_p.Val558fs 2 frameshift (see "Genomic_coordinates" sheet) 1 9 0 9 1 9 20845 27459 4.79708337330902e-05 1.21451561977598e-06 0.000267247072972983 0.999672346002621 0.99937810218515 0.999850165132458 0.1 0.00252857854446178 0.445016117028195 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.667480744536141 0.012862046679265 139.5 5574 False False 0.146366035020388 0.00334344690875921 1.0564499909134 0 0 0.000176951454458875 0.999672346002621 0.99937810218515 0.999850165132458 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 13374 21307 0 0 0.000275786657608973 0.999718481677849 0.999387354605726 0.999896680954833 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.35335561005417 0.0884814409570568 164 4479 False False 0 0 0 0 0 0 0 0 0 1.35335561005417 0 0 0.000275786657608973 0.999718481677849 0.999387354605726 0.999896680954833 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Val558Gly Rv2752c_p.Val558Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 20846 27463 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.43785249906968 0.0743380732312645 251 5574 False False 0 0 1.43785249906968 0 0 0.00017694296670111 0.999817970001456 0.999575254267103 0.999940892797913 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 13374 21311 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.48535171137227 0.526178307844236 803 4479 False False 0 0 0 0 0 0 0 0 0 8.48535171137227 0 0 0.000275786657608973 0.999906160559283 0.999661061221376 0.999988635406343 NA 3) Uncertain significance No change no 1 +Isoniazid Rv2752c p.Val57Gly Rv2752c_p.Val57Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 20844 27468 9.59416674661805e-05 1.16191922227078e-05 0.000346530862189542 1 0.999865711673152 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 5491 5574 False False Inf 0.247471899512553 Inf 0 0 0.000176959943030976 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 13372 21313 0.000149543891132047 1.81109721013608e-05 0.000540098445265982 1 0.999826933785262 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4410 4479 False False 0 0 0 0 0 0 0 Inf 0.299307766452077 Inf 0 0 0.000275827900298067 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Val67Gly Rv2752c_p.Val67Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 20842 27468 0.000191883334932361 5.22841461271422e-05 0.000491224000965345 1 0.999865711673152 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 5358 5574 False False Inf 0.869878292971449 Inf 0 0 0.000176976922618654 1 0.999865711673152 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 13370 21313 0.000299087782264094 8.14971745887464e-05 0.000765604832862923 1 0.999826933785262 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 4311 4479 False False 0 0 0 0 0 0 0 Inf 1.05210128917758 Inf 0 0 0.000275869155324334 1 0.999826933785262 1 NA 3) Uncertain significance New Uncertain no 0 +Isoniazid Rv2752c p.Val67Ile Rv2752c_p.Val67Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 20846 27467 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 0 0 0.975 0 0 0.975 0 0 0.975 0 0 51.3484236392164 1 2027.5 5574 False False 0 0 51.3484236392164 0 0 0.00017694296670111 0.999963594000291 0.999797175631493 0.999999078280314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 13374 21312 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 0 0 0.975 0 0 0.975 0 0 0.975 0 0 62.0916370035077 1 1642.5 4479 False False 0 0 0 0 0 0 0 0 0 62.0916370035077 0 0 0.000275786657608973 0.999953080279641 0.999738608085756 0.999998812096234 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA c.102G>A bacA_c.102G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.1044G>A bacA_c.1044G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 207 632 3339 20140 0.0583756345177665 0.0508846017751684 0.0666045860747859 0.969574427113422 0.967147926357008 0.971868299579617 0.246722288438617 0.217887436941829 0.277348340534817 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.9755877034358 1.67308173624768 2.3252273840971 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 148 257 1459 6096 0.0920970752955818 0.0784031282733597 0.10730133679256 0.959546670864158 0.95440773070397 0.964258043954319 0.365432098765432 0.318432648031288 0.414413961741167 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.40612540437323 1.93592453283707 2.98147274464159 NA NA NA NA NA NA 1415 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.105C>G bacA_c.105C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.1062G>A bacA_c.1062G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.1065T>G bacA_c.1065T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 3543 20772 0.000846023688663282 0.000174504417422474 0.00247043033885164 1 0.99982242673208 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 2.42140315163361 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 1605 6353 0.00124455507156191 0.000150756945780856 0.00448845844972244 1 0.999419516970794 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.742689158362403 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.1080G>A bacA_c.1080G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.2177754884198 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.1140G>A bacA_c.1140G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.1170G>A bacA_c.1170G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.1194C>T bacA_c.1194C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.1210C>T bacA_c.1210C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.1212G>A bacA_c.1212G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.1212G>C bacA_c.1212G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.1242G>A bacA_c.1242G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.2177754884198 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 23 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.129T>C bacA_c.129T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.1321C>A bacA_c.1321C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.1323G>C bacA_c.1323G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.1348C>T bacA_c.1348C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.135G>A bacA_c.135G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.1374C>T bacA_c.1374C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.138C>G bacA_c.138C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.1405C>T bacA_c.1405C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.1426C>T bacA_c.1426C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.2177754884198 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.1428G>A bacA_c.1428G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.1437C>T bacA_c.1437C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.2177754884198 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.1461G>A bacA_c.1461G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.1476G>A bacA_c.1476G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.1527C>T bacA_c.1527C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.1533G>A bacA_c.1533G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.2177754884198 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.1542C>T bacA_c.1542C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 9 207 3537 20565 0.00253807106598984 0.001161204060764 0.00481255792904073 0.99003466204506 0.988589007566085 0.991340570400528 0.0416666666666666 0.0192269285693841 0.077620226633299 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.252793450602942 0.113869322549421 0.489935450442569 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 2 74 1605 6279 0.00124455507156191 0.000150756945780856 0.00448845844972244 0.988351959704076 0.985398743700734 0.990843020982796 0.0263157894736842 0.00320300534473253 0.0918495233231658 NA NA NA NA NA NA NA NA NA NA NA NA False True 1 1 1 0 0 0 0 0.105733771154331 0.0125616449453236 0.396499298892197 NA NA NA NA NA NA 331 5) Not assoc w R Now listed Silent mutation no 0 +Kanamycin bacA c.1551G>C bacA_c.1551G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.1572C>T bacA_c.1572C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.1575G>T bacA_c.1575G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.1608A>T bacA_c.1608A>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 10 3546 20762 0 0 0.0010397522169524 0.99951858270749 0.999114835261082 0.999769118326375 0 0 0.30849710781876 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.61340113759526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 64 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.1617C>T bacA_c.1617C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.2177754884198 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.1621C>T bacA_c.1621C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.87534793394977 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.1623G>A bacA_c.1623G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 251 3544 20521 0.000564015792442188 6.83122290578968e-05 0.00203591855262226 0.98791642595802 0.98633627000063 0.989357726107046 0.00790513833992094 0.00095878676999277 0.0282627381541785 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.046138246112615 0.00556603393418058 0.16856693411585 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.57085126512166 NA NA NA NA NA NA 648 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.1632A>G bacA_c.1632A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.1659C>A bacA_c.1659C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 14.1782880202046 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.1665G>A bacA_c.1665G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.1779G>A bacA_c.1779G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.1794G>A bacA_c.1794G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.1821T>C bacA_c.1821T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 14.1782880202046 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.57085126512166 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.1839G>A bacA_c.1839G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.1842G>A bacA_c.1842G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.1848A>G bacA_c.1848A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.2177754884198 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.1857C>T bacA_c.1857C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.1869T>C bacA_c.1869T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 14.1782880202046 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.189C>T bacA_c.189C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.-18T>C bacA_c.-18T>C 2 upstream_gene_variant 2064746 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1763 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA c.1917G>A bacA_c.1917G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.1917G>C bacA_c.1917G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.2177754884198 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.1919A>G bacA_c.1919A>G 2 stop_retained_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.201G>A bacA_c.201G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.2177754884198 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.-21G>A bacA_c.-21G>A 2 upstream_gene_variant 2064749 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA c.234A>C bacA_c.234A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.2177754884198 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.240G>A bacA_c.240G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.243A>G bacA_c.243A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 5 3545 20767 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999759291353745 0.999438356476751 0.999921838086342 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.17162200282087 0.0247643691956443 10.4748703386698 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 1606 6351 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.99968518810011 0.99886325869706 0.999961872544366 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.97727272727272 0.0334940093351611 38.0316888278718 NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.250C>T bacA_c.250C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.267C>T bacA_c.267C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.270C>T bacA_c.270C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.282C>T bacA_c.282C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 3546 20767 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 6.39361750002021 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.291G>A bacA_c.291G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.309C>T bacA_c.309C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 9 3546 20763 0 0 0.0010397522169524 0.999566724436741 0.999177668076772 0.99980186029375 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.96786458045639 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA 48 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.312G>A bacA_c.312G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.2177754884198 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.-32G>A bacA_c.-32G>A 2 upstream_gene_variant 2064760 NA 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1795 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA c.-32G>T bacA_c.-32G>T 2 upstream_gene_variant 2064760 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA c.-33C>T bacA_c.-33C>T 2 upstream_gene_variant 2064761 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA c.-34C>A bacA_c.-34C>A 2 upstream_gene_variant 2064762 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA c.351C>T bacA_c.351C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.357A>G bacA_c.357A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 14.1782880202046 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.375C>T bacA_c.375C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.414G>A bacA_c.414G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.438G>A bacA_c.438G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.501C>T bacA_c.501C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.507G>A bacA_c.507G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 20 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.-50C>T bacA_c.-50C>T 2 upstream_gene_variant 2064778 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA c.510C>T bacA_c.510C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.516C>T bacA_c.516C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.87534793394977 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.-52A>C bacA_c.-52A>C 2 upstream_gene_variant 2064780 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA c.588C>A bacA_c.588C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.-58T>C bacA_c.-58T>C 2 upstream_gene_variant 2064786 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA c.624C>T bacA_c.624C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.633C>G bacA_c.633C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.63T>C bacA_c.63T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 16 3546 20756 0 0 0.0010397522169524 0.999229732331985 0.998749434152838 0.999559663409708 0 0 0.205907214207822 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.51862445866705 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 15 1607 6338 0 0 0.0022928741555424 0.997638910750826 0.996108727739866 0.998677932833021 0 0 0.218019360910534 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.10108282293089 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.651G>A bacA_c.651G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.2177754884198 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 13 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.651G>C bacA_c.651G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.678T>A bacA_c.678T>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.678T>C bacA_c.678T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.-67G>C bacA_c.-67G>C 2 upstream_gene_variant 2064795 1 3 0 3 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 14.1782880202046 1 617 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.0580478247511 1 233 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 2 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA c.681T>G bacA_c.681T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 3546 20766 0 0 0.0010397522169524 0.999711149624494 0.999371401166804 0.999893989862555 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.9758630843129 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.0580478247511 NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.705C>T bacA_c.705C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.714C>G bacA_c.714C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.2177754884198 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.759C>A bacA_c.759C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.2177754884198 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.762G>T bacA_c.762G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.2177754884198 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.-76G>A bacA_c.-76G>A 2 upstream_gene_variant 2064804 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1755 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 953 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA c.783C>T bacA_c.783C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.2177754884198 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA c.-81_-76dupTCGGTG bacA_c.-81_-76dupTCGGTG 2 upstream_gene_variant 2064803 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA c.84G>C bacA_c.84G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin bacA deletion bacA_deletion 2 feature_ablation (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1744 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA LoF bacA_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 18 2 16 18 39 3528 20733 0.00507614213197969 0.00301113478216789 0.00801067203396699 0.998122472559214 0.997434242728671 0.998664564276397 0.31578947368421 0.199050077738218 0.452429841788771 0.111111111111111 0.0137512156643644 0.347120438608672 0.048780487804878 0.00596311824104283 0.16533335341783 0.734587585034013 0.0819037660551024 3.1268039369422 1 617 1879 False False 2.71232339089481 1.45859654910359 4.86131301935754 0.000566572237960339 6.86218928023383e-05 0.00204513968300958 0.998122472559214 0.997434242728671 0.998664564276397 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 1 5 10 15 1597 6338 0.00622277535780958 0.00298797623318756 0.0114140395320774 0.997638910750826 0.996108727739866 0.998677932833021 0.4 0.211254806465142 0.61334650374316 0.166666666666666 0.00421074451448947 0.641234578997674 0.0625 0.00158111172276588 0.302320738434531 0.793738259236067 0.0167713772349129 7.10066746954348 1 233 992 False False 0 0 0 0 0 0 0 2.64579419745355 1.06066228372942 6.30807869374574 0.00062578222778473 1.58433087764928e-05 0.00348165212472099 0.997638910750826 0.996108727739866 0.998677932833021 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Ala152Val bacA_p.Ala152Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Ala170Thr bacA_p.Ala170Thr 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1777 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 959 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Ala211Pro bacA_p.Ala211Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Ala249Thr bacA_p.Ala249Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Ala285Thr bacA_p.Ala285Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.0580478247511 1 233 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Ala299Thr bacA_p.Ala299Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 14.1776055911046 1 193 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.57085126512166 1 233 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 2 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Ala359Val bacA_p.Ala359Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 3545 20771 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999951858270749 0.999731800967312 0.999998781157685 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 5.8592383638928 0.0746220616644107 458.169367733398 0.270378083801644 96 1879 False False 5.8592383638928 0.0746220616644107 458.169367733398 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Ala36Gly bacA_p.Ala36Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Ala396Val bacA_p.Ala396Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Ala413Thr bacA_p.Ala413Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1765 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Ala438Val bacA_p.Ala438Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Ala464Thr bacA_p.Ala464Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Ala464Val bacA_p.Ala464Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Ala474Gly bacA_p.Ala474Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 3 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Ala523Thr bacA_p.Ala523Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1740 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Ala535Thr bacA_p.Ala535Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1780 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Ala588Thr bacA_p.Ala588Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1787 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Ala630Val bacA_p.Ala630Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 3546 20767 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 8.87492061244508 1 193 1879 False False 0 0 6.39361750002021 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 16 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Ala634Thr bacA_p.Ala634Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1749 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Arg115Ser bacA_p.Arg115Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Arg119Gln bacA_p.Arg119Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1751 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Arg169Lys bacA_p.Arg169Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Arg278Cys bacA_p.Arg278Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Arg326His bacA_p.Arg326His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1742 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Arg329Leu bacA_p.Arg329Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1788 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 964 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 2 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Arg356Gln bacA_p.Arg356Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1802 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Arg452Leu bacA_p.Arg452Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Arg486Gln bacA_p.Arg486Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1758 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Arg508Cys bacA_p.Arg508Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 227.636869136849 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Arg508Pro bacA_p.Arg508Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1798 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Arg545Cys bacA_p.Arg545Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Arg545Ser bacA_p.Arg545Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1747 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Arg594His bacA_p.Arg594His 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Asn183His bacA_p.Asn183His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Asn279Thr bacA_p.Asn279Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Asn335Ser bacA_p.Asn335Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1801 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 968 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 6 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Asn515Thr bacA_p.Asn515Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1745 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Asn85Ser bacA_p.Asn85Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Asp110Ala bacA_p.Asp110Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1796 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Asp178Glu bacA_p.Asp178Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Asp18Asn bacA_p.Asp18Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Asp379fs bacA_p.Asp379fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Asp379His bacA_p.Asp379His 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 8.87534793394977 1 617 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Asp406Ala bacA_p.Asp406Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1789 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Asp423Gly bacA_p.Asp423Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1775 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Asp451Asn bacA_p.Asp451Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Asp451Glu bacA_p.Asp451Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1781 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Asp509Asn bacA_p.Asp509Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1803 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Asp546Ala bacA_p.Asp546Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 13 0 13 0 15 3546 20757 0 0 0.0010397522169524 0.999277874061236 0.998809242329947 0.999595777053137 0 0 0.218019360910534 0 0 0.24705263800047 0 0 0.218019360910534 0 0 1.92169933515892 0.237586055075226 83 1879 False False 0 0 1.6329175925414 0 0 0.0010397522169524 0.999277874061236 0.998809242329947 0.999595777053137 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 153.787547206498 1 233 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 25 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Asp599Ala bacA_p.Asp599Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1741 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Cys33Tyr bacA_p.Cys33Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1797 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Cys538Arg bacA_p.Cys538Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1748 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Cys538Gly bacA_p.Cys538Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Gln100His bacA_p.Gln100His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1760 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Gln361Lys bacA_p.Gln361Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Gln618Leu bacA_p.Gln618Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Glu298Asp bacA_p.Glu298Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Glu309Asp bacA_p.Glu309Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1783 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Glu433Lys bacA_p.Glu433Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Glu490Lys bacA_p.Glu490Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1799 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Glu492Gln bacA_p.Glu492Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1793 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Glu633Gln bacA_p.Glu633Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 31.2162477992404 1 193 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Glu638Lys bacA_p.Glu638Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Gly105Asp bacA_p.Gly105Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1768 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Gly168Arg bacA_p.Gly168Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1784 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Gly168Ser bacA_p.Gly168Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1759 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Gly310Ser bacA_p.Gly310Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.150201697158088 Inf 0.14581791265729 60 1879 False False Inf 0.150201697158088 Inf 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Gly360Arg bacA_p.Gly360Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Gly403Glu bacA_p.Gly403Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Gly554fs bacA_p.Gly554fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 8 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Gly584Glu bacA_p.Gly584Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1804 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Gly624Asp bacA_p.Gly624Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1805 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Gly625Ser bacA_p.Gly625Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1790 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 965 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Gly72Ala bacA_p.Gly72Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.His615Tyr bacA_p.His615Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1761 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Ile264Thr bacA_p.Ile264Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1750 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Ile273Met bacA_p.Ile273Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Ile273Thr bacA_p.Ile273Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 439 12 427 213 635 3333 20137 0.060067681895093 0.0524712604688518 0.0683989685125147 0.969430001925669 0.966998162812973 0.971729257589363 0.251179245283018 0.22230640064562 0.281792622182567 0.0273348519362186 0.0142023691720355 0.0472613397381183 0.0185471406491499 0.00961938607226156 0.0321738182116236 0.169790281135841 0.0869340754713062 0.300167861301941 9.57312622678091e-16 7 1879 True False 2.02658738314776 1.71942396926422 2.38117162981476 0.00358744394618834 0.00185501635970319 0.00625814879465119 0.969430001925669 0.966998162812973 0.971729257589363 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 167 6 161 154 263 1453 6090 0.0958307405102675 0.0818760642519212 0.111281177535636 0.958602235164489 0.953410019156739 0.963367859830647 0.369304556354916 0.322855855899754 0.417622389878651 0.0359281437125748 0.0132971254332162 0.0765573035016032 0.0223048327137546 0.00822844984199311 0.0479135319995721 0.156198569675932 0.056386023456196 0.348546731324759 5.06818507937709e-09 7 992 True False 0 0 0 0 0 0 0 2.45423785585873 1.98146875123027 3.0310071931663 0.00411240575736806 0.00151063007134899 0.00892933580640698 0.958602235164489 0.953410019156739 0.963367859830647 1423 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Ile321Thr bacA_p.Ile321Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Ile443Val bacA_p.Ile443Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Ile520fs bacA_p.Ile520fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Ile520Phe bacA_p.Ile520Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1785 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 962 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Ile54fs bacA_p.Ile54fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1778 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 960 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Ile603Val bacA_p.Ile603Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 33 1463 3513 19309 0.0093062605752961 0.00641441556315769 0.013044834813662 0.929568650105911 0.926004454086143 0.933012050099858 0.0220588235294117 0.0152317684498373 0.0308403069026249 NA NA NA 0 0 0.00251827252241419 NA NA NA NA 1786 1879 False True 0.123979889946899 0.084863121243973 0.175298593487603 0 0 0.00104951419005625 0.929568650105911 0.926004454086143 0.933012050099858 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 9 319 1598 6034 0.00560049782202862 0.00256400651532502 0.0106047563737941 0.949787501967574 0.944128669284971 0.955028695699816 0.0274390243902439 0.0126220039804608 0.0514470736701302 NA NA NA 0 0 0.0114972806966447 NA NA NA NA 963 992 False True 1 1 1 0 0 0 0 0.106532067906199 0.0481666134673416 0.205465934115259 0 0 0.00230577281532563 0.949787501967574 0.944128669284971 0.955028695699816 3475 5) Not assoc w R New NotAwR yes 5 +Kanamycin bacA p.Leu157Pro bacA_p.Leu157Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Leu175Val bacA_p.Leu175Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1762 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Leu313Ile bacA_p.Leu313Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Leu446Arg bacA_p.Leu446Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Leu44Ser bacA_p.Leu44Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Leu470fs bacA_p.Leu470fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1782 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 961 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Leu551fs bacA_p.Leu551fs 2 frameshift (see "Genomic_coordinates" sheet) 1 9 0 9 10 17 3536 20755 0.00282007896221094 0.00135314014136576 0.00518009078773565 0.999181590602734 0.998689969592855 0.99952317637802 0.37037037037037 0.194007158715135 0.576320427495704 0 0 0.336267116879942 0 0 0.195064322969093 0 0 2.97511140980021 0.374153632135817 107 1879 False False 3.4527215863721 1.41153538772194 7.99077920944065 0 0 0.00104269115914271 0.999181590602734 0.998689969592855 0.99952317637802 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 6 3 1601 6350 0.00373366521468575 0.00137138406067734 0.00810877842801138 0.999527782150165 0.998620605323549 0.999902606737868 0.666666666666666 0.29929505620854 0.925145368580308 0 0 0.841886116991581 0 0 0.707598226178713 0 0 21.1335016659764 1 233 992 False False 0 0 0 0 0 0 0 7.93254216114928 1.69133449815739 49.1111822014985 0 0 0.00230145716737395 0.999527782150165 0.998620605323549 0.999902606737868 11 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Leu585Pro bacA_p.Leu585Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Leu75fs bacA_p.Leu75fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1769 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 955 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Lys4Asn bacA_p.Lys4Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 6 3546 20766 0 0 0.0010397522169524 0.999711149624494 0.999371401166804 0.999893989862555 0 0 0.4592581264399 0 0 0.602364635616474 0 0 0.4592581264399 0 0 8.874493290938 1 617 1879 False False 0 0 4.9758630843129 0 0 0.0010397522169524 0.999711149624494 0.999371401166804 0.999893989862555 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 950 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Lys549Thr bacA_p.Lys549Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 9 3546 20763 0 0 0.0010397522169524 0.999566724436741 0.999177668076772 0.99980186029375 0 0 0.336267116879942 0 0 0.602364635616474 0 0 0.336267116879942 0 0 8.87321132640249 1 193 1879 False False 0 0 2.96786458045639 0 0 0.0010397522169524 0.999566724436741 0.999177668076772 0.99980186029375 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 6 1607 6347 0 0 0.0022928741555424 0.99905556430033 0.997945503023207 0.999653332387469 0 0 0.4592581264399 0 0 0.707598226178713 0 0 0.4592581264399 0 0 9.56633211005539 1 233 992 False False 0 0 0 0 0 0 0 0 0 3.35786664322939 0 0 0.0022928741555424 0.99905556430033 0.997945503023207 0.999653332387469 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Met1? bacA_p.Met1? 2 start_lost (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1771 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 956 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Met131Thr bacA_p.Met131Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1752 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Met131Val bacA_p.Met131Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1770 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Met250Val bacA_p.Met250Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1753 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Met494Leu bacA_p.Met494Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 14.1782880202046 1 617 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Met95Ile bacA_p.Met95Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1791 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 966 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 7 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Phe302fs bacA_p.Phe302fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1779 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Phe384Val bacA_p.Phe384Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Pro17Leu bacA_p.Pro17Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1757 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Pro347Leu bacA_p.Pro347Leu 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 7 15 3539 20757 0.00197405527354765 0.000794029400507555 0.00406305244102797 0.999277874061236 0.998809242329947 0.999595777053137 0.318181818181818 0.138646521553797 0.54872442757377 NA NA NA 0 0 0.218019360910534 NA NA NA NA 1773 1879 False False 2.73710087595365 0.943341912302496 7.13768290967916 0 0 0.00104180773346159 0.999277874061236 0.998809242329947 0.999595777053137 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 957 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Pro3Thr bacA_p.Pro3Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Pro437Leu bacA_p.Pro437Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Pro536Arg bacA_p.Pro536Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.150201697158088 Inf 0.14581791265729 60 1879 False False Inf 0.150201697158088 Inf 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Pro609His bacA_p.Pro609His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Pro609Ser bacA_p.Pro609Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Pro8Leu bacA_p.Pro8Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Ser116Leu bacA_p.Ser116Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1766 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Ser207Ala bacA_p.Ser207Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Ser245Phe bacA_p.Ser245Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Ser481Ala bacA_p.Ser481Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1800 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Ser552fs bacA_p.Ser552fs 2 frameshift (see "Genomic_coordinates" sheet) 1 4 1 3 6 10 3540 20762 0.00169204737732656 0.000621196730345483 0.00367920983862615 0.99951858270749 0.999114835261082 0.999769118326375 0.375 0.151983675081122 0.645653905697921 0.25 0.00630946320970987 0.805879550316756 0.0909090909090909 0.00229897221381426 0.412779916988382 1.95499058380414 0.0372293529476568 24.372073778806 0.46733337788839 120 1879 False False 3.51898305084745 1.0503951497103 10.6921539224714 0.000282406099971759 7.14987785217869e-06 0.00157245073668775 0.99951858270749 0.999114835261082 0.999769118326375 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 4 1605 6349 0.00124455507156191 0.000150756945780856 0.00448845844972244 0.99937037620022 0.998388704765699 0.99982842290899 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.975 0 0 0.602364635616474 0 0 153.930356361652 1 233 992 False False 0 0 0 0 0 0 0 1.97788161993769 0.178739259054919 13.8135366697626 0 0 0.0022957280374523 0.99937037620022 0.998388704765699 0.99982842290899 1 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Ser604Cys bacA_p.Ser604Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Thr112Ala bacA_p.Thr112Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 6 3546 20766 0 0 0.0010397522169524 0.999711149624494 0.999371401166804 0.999893989862555 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1792 1879 False False 0 0 4.9758630843129 0 0 0.0010397522169524 0.999711149624494 0.999371401166804 0.999893989862555 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 967 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 4 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Thr158Ile bacA_p.Thr158Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Thr210Ala bacA_p.Thr210Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Thr210Lys bacA_p.Thr210Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 227.636869136849 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Thr419Ala bacA_p.Thr419Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1754 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 952 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Thr419Ile bacA_p.Thr419Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1794 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Thr419Pro bacA_p.Thr419Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1746 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Thr436Met bacA_p.Thr436Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Thr45Ala bacA_p.Thr45Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 9 2 3537 20770 0.00253807106598984 0.001161204060764 0.00481255792904073 0.999903716541498 0.99965223478104 0.999988339413789 0.818181818181818 0.482244147639827 0.97716880170004 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.298548717307 1 617 1879 False False 26.4249363867684 5.46526640788106 250.051770997435 0 0 0.0010423965174912 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 4 2 1603 6351 0.00248911014312383 0.000678602218007884 0.00636074311848652 0.99968518810011 0.99886325869706 0.999961872544366 0.666666666666666 0.222778095503512 0.956728131707258 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.1104981923963 1 233 992 False False 0 0 0 0 0 0 0 7.92389270118527 1.13411259454955 87.7838935728309 0 0 0.00229858903252049 0.99968518810011 0.99886325869706 0.999961872544366 3 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Thr467Ser bacA_p.Thr467Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Thr483Ile bacA_p.Thr483Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1756 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Thr506Lys bacA_p.Thr506Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1767 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 954 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Trp122Ser bacA_p.Trp122Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1772 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Trp122* bacA_p.Trp122* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1743 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 951 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Trp153Ser bacA_p.Trp153Ser 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 5 73 3541 20699 0.00141003948110547 0.000457989490992675 0.00328746875206548 0.996485653764683 0.995583236527684 0.997244332424264 0.0641025641025641 0.0211397204114613 0.143287596106885 NA NA NA 0 0 0.0492770608958592 NA NA NA NA 1806 1879 False False 0.400378346802427 0.126156818373954 0.97867727172394 0 0 0.00104121961419034 0.996485653764683 0.995583236527684 0.997244332424264 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 1607 6347 0 0 0.0022928741555424 0.99905556430033 0.997945503023207 0.999653332387469 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 969 992 False False 0 0 0 0 0 0 0 0 0 3.35786664322939 0 0 0.0022928741555424 0.99905556430033 0.997945503023207 0.999653332387469 43 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Trp153* bacA_p.Trp153* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1776 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 958 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Trp156Cys bacA_p.Trp156Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1764 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Trp627Arg bacA_p.Trp627Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 1 6 1 6 3545 20766 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999711149624494 0.999371401166804 0.999893989862555 0.142857142857142 0.00361029686190058 0.578723197043195 0.142857142857142 0.00361029686190058 0.578723197043195 0.142857142857142 0.00361029686190058 0.578723197043195 0.976304654442877 0.0212191705766405 8.05133152464184 1 617 1879 False False 0.976304654442877 0.0212191705766405 8.05133152464184 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999711149624494 0.999371401166804 0.999893989862555 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Tyr144Asp bacA_p.Tyr144Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Tyr171Asp bacA_p.Tyr171Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Tyr172Cys bacA_p.Tyr172Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Tyr43Ser bacA_p.Tyr43Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.150201697158088 Inf 0.14581791265729 60 1879 False False Inf 0.150201697158088 Inf 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Tyr513Cys bacA_p.Tyr513Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1774 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Tyr90Cys bacA_p.Tyr90Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Val136Met bacA_p.Val136Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Val139Ile bacA_p.Val139Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Val219Ala bacA_p.Val219Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Val291Phe bacA_p.Val291Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Val308Ala bacA_p.Val308Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Val351fs bacA_p.Val351fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.150201697158088 Inf 0.14581791265729 60 1879 False False Inf 0.150201697158088 Inf 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.101367337197729 Inf 0.201884422110552 36.5 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Val351Ile bacA_p.Val351Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Val502Leu bacA_p.Val502Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin bacA p.Val510Ala bacA_p.Val510Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 227.615028370197 1 617 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 4 1607 6349 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 153.739241752309 1 233 992 False False 0 0 0 0 0 0 0 0 0 5.99028746746614 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA c.-106G>C ccsA_c.-106G>C 2 upstream_gene_variant 619785 1 7 0 7 4 16 3542 20756 0.00112803158488437 0.000307433460438748 0.00288566784728404 0.999229732331985 0.998749434152838 0.999559663409708 0.2 0.0573339970500327 0.436614002996668 0 0 0.409616397225003 0 0 0.205907214207822 0 0 4.06763490062147 0.603466999502616 138 1879 False False 1.46499153020892 0.356197860569158 4.54454640369097 0 0 0.00104092580348739 0.999229732331985 0.998749434152838 0.999559663409708 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 4 16 1603 6337 0.00248911014312383 0.000678602218007884 0.00636074311848652 0.997481504800881 0.995913335169992 0.998559798442438 0.2 0.0573339970500327 0.436614002996668 0 0 0.409616397225003 0 0 0.205907214207822 0 0 2.74584355176298 0.35735931394962 51 992 False False 0 0 0 0 0 0 0 0.988303181534622 0.240109846900781 3.06923711605059 0 0 0.00229858903252049 0.997481504800881 0.995913335169992 0.998559798442438 3 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA c.-107G>A ccsA_c.-107G>A 2 upstream_gene_variant 619784 NA 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1696 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA c.-10G>A ccsA_c.-10G>A 2 upstream_gene_variant 619881 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1708 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 938 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA c.126C>T ccsA_c.126C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 6 0 3540 20772 0.00169204737732656 0.000621196730345483 0.00367920983862615 1 0.99982242673208 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 6.9045922851375 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.-134G>T ccsA_c.-134G>T 2 upstream_gene_variant 619757 NA 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1715 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA c.139C>T ccsA_c.139C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 12 317 3534 20455 0.00338409475465313 0.00174979607500839 0.00590386326830579 0.98473907182746 0.982978372984869 0.986362129081574 0.0364741641337386 0.0189862159338245 0.0628457834528983 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.219106328964774 0.111900389664985 0.3887241980902 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 28 1606 6325 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.995592633401542 0.993636381028915 0.997069399007024 0.0344827586206896 0.000872646883579922 0.177644295488722 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.140655577299412 0.00344145814946179 0.852227255378434 NA NA NA NA NA NA 259 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.-141C>T ccsA_c.-141C>T 2 upstream_gene_variant 619750 1 0 0 0 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1733 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1607 6349 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 947 992 False False 0 0 0 0 0 0 0 0 0 5.99028746746614 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA c.-143G>A ccsA_c.-143G>A 2 upstream_gene_variant 619748 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA c.-144C>A ccsA_c.-144C>A 2 upstream_gene_variant 619747 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1701 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA c.144C>T ccsA_c.144C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.-149G>A ccsA_c.-149G>A 2 upstream_gene_variant 619742 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA c.150G>A ccsA_c.150G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.-162G>A ccsA_c.-162G>A 2 upstream_gene_variant 619729 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1729 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA c.-168G>A ccsA_c.-168G>A 2 upstream_gene_variant 619723 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA c.-16C>T ccsA_c.-16C>T 2 upstream_gene_variant 619875 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1697 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA c.189C>T ccsA_c.189C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.2177754884198 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.18C>G ccsA_c.18C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.2177754884198 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.18C>T ccsA_c.18C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 14.1782880202046 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.-191C>T ccsA_c.-191C>T 2 upstream_gene_variant 619700 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1698 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA c.195G>A ccsA_c.195G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.-22C>A ccsA_c.-22C>A 2 upstream_gene_variant 619869 1 5 0 5 0 5 3546 20767 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 6.39361750002021 1 617 1879 False False 0 0 6.39361750002021 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA c.231G>T ccsA_c.231G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.234G>A ccsA_c.234G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.150201697158088 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.240G>T ccsA_c.240G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.27C>T ccsA_c.27C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.282C>T ccsA_c.282C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.288G>C ccsA_c.288G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.291G>A ccsA_c.291G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.-30_-29insGCG ccsA_c.-30_-29insGCG 2 upstream_gene_variant 619861 1 1 0 1 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 227.636869136849 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA c.-30A>G ccsA_c.-30A>G 2 upstream_gene_variant 619861 NA 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1724 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 945 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA c.339C>T ccsA_c.339C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.2177754884198 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.351C>T ccsA_c.351C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 3546 20766 0 0 0.0010397522169524 0.999711149624494 0.999371401166804 0.999893989862555 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.9758630843129 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.0580478247511 NA NA NA NA NA NA 13 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.372C>T ccsA_c.372C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.2177754884198 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.-38_-37insT ccsA_c.-38_-37insT 2 upstream_gene_variant 619853 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA c.381C>T ccsA_c.381C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.2177754884198 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.390C>T ccsA_c.390C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 6 3542 20766 0.00112803158488437 0.000307433460438748 0.00288566784728404 0.999711149624494 0.999371401166804 0.999893989862555 0.4 0.121552258119827 0.737621923393055 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.90852625635234 0.810756615706101 16.4940686253274 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.393T>G ccsA_c.393T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.2177754884198 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.424C>T ccsA_c.424C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.426G>C ccsA_c.426G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.150201697158088 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.435G>A ccsA_c.435G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 3546 20767 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 6.39361750002021 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.57085126512166 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.468C>T ccsA_c.468C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 10 3542 20762 0.00112803158488437 0.000307433460438748 0.00288566784728404 0.99951858270749 0.999114835261082 0.999769118326375 0.285714285714285 0.0838893183071275 0.581035257183661 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.34466403162055 0.536437828573761 8.13424985512572 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 4 9 1603 6344 0.00248911014312383 0.000678602218007884 0.00636074311848652 0.998583346450495 0.997312461277908 0.999352017626566 0.307692307692307 0.0909203945720966 0.614261661750705 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.75892423927358 0.395270826046445 6.31175642358521 NA NA NA NA NA NA 19 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.474C>T ccsA_c.474C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.150201697158088 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.507C>T ccsA_c.507C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.150201697158088 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.519C>T ccsA_c.519C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.525T>C ccsA_c.525T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.528G>A ccsA_c.528G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.87534793394977 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA 15 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.-52C>T ccsA_c.-52C>T 2 upstream_gene_variant 619839 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1725 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 946 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA c.543C>G ccsA_c.543C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.561G>A ccsA_c.561G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.567C>T ccsA_c.567C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.573C>T ccsA_c.573C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.576C>T ccsA_c.576C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.582C>T ccsA_c.582C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 3546 20767 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 6.39361750002021 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.585G>A ccsA_c.585G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 14.1782880202046 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.600A>C ccsA_c.600A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.607C>T ccsA_c.607C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.621C>T ccsA_c.621C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.630C>T ccsA_c.630C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.2177754884198 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.634C>T ccsA_c.634C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.2177754884198 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.636G>T ccsA_c.636G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.87534793394977 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.63C>T ccsA_c.63C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.648G>A ccsA_c.648G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.663T>C ccsA_c.663T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 30 242 3516 20530 0.00846023688663282 0.00571515760395069 0.0120556527842865 0.988349701521278 0.986795999280553 0.989764372444091 0.110294117647058 0.0756632874472202 0.153697196178485 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.723845654810594 0.477177610746679 1.06252775905052 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 9 44 1598 6309 0.00560049782202862 0.00256400651532502 0.0106047563737941 0.993074138202424 0.99071338938027 0.994963279451983 0.169811320754716 0.0807088764668229 0.298021668105402 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.807557742632836 0.345897030165369 1.68071268768295 NA NA NA NA NA NA 12 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.673C>T ccsA_c.673C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.684C>T ccsA_c.684C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.687C>A ccsA_c.687C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.696C>T ccsA_c.696C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 3546 20766 0 0 0.0010397522169524 0.999711149624494 0.999371401166804 0.999893989862555 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.9758630843129 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 1607 6349 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 5.99028746746614 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.69G>A ccsA_c.69G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.-69G>T ccsA_c.-69G>T 2 upstream_gene_variant 619822 1 0 0 0 0 14 3546 20758 0 0 0.0010397522169524 0.999326015790487 0.998869427329123 0.999631479131688 0 0 0.231635761650116 NA NA NA 0 0 0.231635761650116 NA NA NA NA 1689 1879 False False 0 0 1.76565880831751 0 0 0.0010397522169524 0.999326015790487 0.998869427329123 0.999631479131688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA c.708C>T ccsA_c.708C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.714C>T ccsA_c.714C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.720C>T ccsA_c.720C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.2177754884198 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.0580478247511 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.729G>A ccsA_c.729G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 7 3542 20765 0.00112803158488437 0.000307433460438748 0.00288566784728404 0.999663007895243 0.999305791518941 0.999864501305137 0.363636363636363 0.109263443819098 0.692095284988322 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.35000403323384 0.718701884878255 13.1861310847915 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 4 6 1603 6347 0.00248911014312383 0.000678602218007884 0.00636074311848652 0.99905556430033 0.997945503023207 0.999653332387469 0.4 0.121552258119827 0.737621923393055 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.63963401954668 0.547105126171914 11.1445102867659 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.72G>A ccsA_c.72G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 14.1782880202046 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.732G>A ccsA_c.732G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.762C>T ccsA_c.762C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.-76G>C ccsA_c.-76G>C 2 upstream_gene_variant 619815 0 0 0 0 3 16 3543 20756 0.000846023688663282 0.000174504417422474 0.00247043033885164 0.999229732331985 0.998749434152838 0.999559663409708 0.157894736842105 0.0338262490017646 0.395784551266674 NA NA NA 0 0 0.205907214207822 NA NA NA NA 1702 1879 False False 1.09843353090601 0.204996128215496 3.84028655480137 0 0 0.00104063215855229 0.999229732331985 0.998749434152838 0.999559663409708 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 3 1605 6350 0.00124455507156191 0.000150756945780856 0.00448845844972244 0.999527782150165 0.998620605323549 0.999902606737868 0.4 0.0527449505263169 0.853367200365326 NA NA NA 0 0 0.707598226178713 NA NA NA NA 936 992 False False 0 0 0 0 0 0 0 2.63759086188992 0.220091038914179 23.0414149124911 0 0 0.0022957280374523 0.999527782150165 0.998620605323549 0.999902606737868 10 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA c.771C>T ccsA_c.771C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.2177754884198 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.-77G>A ccsA_c.-77G>A 2 upstream_gene_variant 619814 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA c.-77G>T ccsA_c.-77G>T 2 upstream_gene_variant 619814 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 13 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA c.789C>G ccsA_c.789C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.78G>A ccsA_c.78G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 3546 20767 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 6.39361750002021 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.795G>A ccsA_c.795G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.-79C>T ccsA_c.-79C>T 2 upstream_gene_variant 619812 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1707 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 937 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA c.819G>A ccsA_c.819G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 14.1782880202046 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.0580478247511 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.843G>A ccsA_c.843G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.-85G>A ccsA_c.-85G>A 2 upstream_gene_variant 619806 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA c.870C>A ccsA_c.870C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.879C>G ccsA_c.879C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.894C>T ccsA_c.894C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.2177754884198 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.-89G>A ccsA_c.-89G>A 2 upstream_gene_variant 619802 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1716 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 942 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA c.-89G>C ccsA_c.-89G>C 2 upstream_gene_variant 619802 NA 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1705 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA c.-90_-85delCGAGCG ccsA_c.-90_-85delCGAGCG 2 upstream_gene_variant 619800 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1731 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA c.906C>T ccsA_c.906C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.918T>C ccsA_c.918T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.-93G>C ccsA_c.-93G>C 2 upstream_gene_variant 619798 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA c.963G>C ccsA_c.963G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.-96C>A ccsA_c.-96C>A 2 upstream_gene_variant 619795 NA 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1709 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 939 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 1 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA c.-96C>G ccsA_c.-96C>G 2 upstream_gene_variant 619795 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA c.972C>T ccsA_c.972C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin ccsA c.-99C>T ccsA_c.-99C>T 2 upstream_gene_variant 619792 NA 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1703 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Ala11Val ccsA_p.Ala11Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Ala166Val ccsA_p.Ala166Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1736 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Ala189Thr ccsA_p.Ala189Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 10 1 3536 20771 0.00282007896221094 0.00135314014136576 0.00518009078773565 0.999951858270749 0.999731800967312 0.999998781157685 0.909090909090909 0.587220083011617 0.997701027786185 0 0 0.975 0 0 0.975 0 0 228.289293375563 1 193 1879 False False 58.741515837104 8.34994185313475 2513.05581893245 0 0 0.00104269115914271 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 934 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 3 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Ala211Val ccsA_p.Ala211Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Ala213Val ccsA_p.Ala213Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1711 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Ala229Ser ccsA_p.Ala229Ser 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 5 5 3541 20767 0.00141003948110547 0.000457989490992675 0.00328746875206548 0.999759291353745 0.999438356476751 0.999921838086342 0.5 0.187086028447398 0.812913971552601 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1732 1879 False False 5.86472747811352 1.34887603073477 25.4914975654025 0 0 0.00104121961419034 0.999759291353745 0.999438356476751 0.999921838086342 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Ala285dup ccsA_p.Ala285dup 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Ala293Gly ccsA_p.Ala293Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1734 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 948 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 2 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Ala298Ser ccsA_p.Ala298Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Ala33Val ccsA_p.Ala33Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Ala48Val ccsA_p.Ala48Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1691 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Ala55Val ccsA_p.Ala55Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1719 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Arg131Cys ccsA_p.Arg131Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 3546 20767 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 6.39361750002021 1 617 1879 False False 0 0 6.39361750002021 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 15 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Arg199Cys ccsA_p.Arg199Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Arg202Gly ccsA_p.Arg202Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Arg217Gly ccsA_p.Arg217Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 14.1782880202046 1 617 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Arg217Trp ccsA_p.Arg217Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1737 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 949 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Arg257Cys ccsA_p.Arg257Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 32 0 32 0 34 3546 20738 0 0 0.0010397522169524 0.998363181205468 0.997713453833747 0.998866197296832 0 0 0.102817924259012 0 0 0.108881160679352 0 0 0.102817924259012 0 0 0.714994449205865 0.0105835343615581 28 1879 False False 0 0 0.670625973355984 0 0 0.0010397522169524 0.998363181205468 0.997713453833747 0.998866197296832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 0 9 1607 6344 0 0 0.0022928741555424 0.998583346450495 0.997312461277908 0.999352017626566 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.336267116879942 0 0 2.00246403812054 0.219283706073922 42.5 992 False False 0 0 0 0 0 0 0 0 0 2.00246403812054 0 0 0.0022928741555424 0.998583346450495 0.997312461277908 0.999352017626566 58 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Arg288Gln ccsA_p.Arg288Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Arg68Trp ccsA_p.Arg68Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Asn296Ser ccsA_p.Asn296Ser 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 3545 20771 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999951858270749 0.999731800967312 0.999998781157685 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1699 1879 False False 5.8592383638928 0.0746220616644107 458.169367733398 0 0 0.00104004536542481 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Asp226Asn ccsA_p.Asp226Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 2 8 3544 20764 0.000564015792442188 6.83122290578968e-05 0.00203591855262226 0.999614866165992 0.999241274614236 0.99983371235125 0.2 0.0252107263268333 0.556095462307641 0 0 0.4592581264399 0 0 0.369416647552819 0 0 4.97819268045183 0.602123939818236 137 1879 False False 1.46472911963882 0.151439261401278 7.34364495908934 0 0 0.0010403386792448 0.999614866165992 0.999241274614236 0.99983371235125 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 1606 6351 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.99968518810011 0.99886325869706 0.999961872544366 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 153.883075087497 1 233 992 False False 0 0 0 0 0 0 0 1.97727272727272 0.0334940093351611 38.0316888278718 0 0 0.00229430020901157 0.99968518810011 0.99886325869706 0.999961872544366 3 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Asp57Asn ccsA_p.Asp57Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1710 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 940 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Glu35Gly ccsA_p.Glu35Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Glu74Ala ccsA_p.Glu74Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 227.636869136849 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Gly324Ser ccsA_p.Gly324Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Gly52Arg ccsA_p.Gly52Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1735 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Gly79Ser ccsA_p.Gly79Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Gly99Ala ccsA_p.Gly99Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1712 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Gly9Ser ccsA_p.Gly9Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.His5Asn ccsA_p.His5Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1721 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.His69Arg ccsA_p.His69Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1693 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Ile123Ala ccsA_p.Ile123Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1700 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 935 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 7 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Ile245Met ccsA_p.Ile245Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 4458 93 4365 1721 6842 1825 13930 0.485335589396503 0.468762564468819 0.501932814255765 0.670614288465241 0.664175252007559 0.67700554531891 0.200980964615204 0.192537684217255 0.209628187135976 0.0208613728129205 0.0168700199976123 0.0254963827839157 0.013410237923576 0.0108370666570527 0.0164035992659561 0.1626248646613 0.130259952563333 0.200976749181087 5.32861190929588e-106 2 1879 True False 1.91993288832473 1.78541749207509 2.06444224730159 0.0484880083420229 0.0393116073132023 0.0590742664998154 0.670614288465241 0.664175252007559 0.67700554531891 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1336 30 1306 884 2212 723 4141 0.550093341630367 0.525386178971186 0.574617184709255 0.651818038721863 0.639957184433637 0.663539364797474 0.285529715762273 0.269667101354669 0.301798509830742 0.0224550898203592 0.0152004226937755 0.0319018209653293 0.0133809099018733 0.00904576418798372 0.0190473680150142 0.131566405927319 0.0876731727661308 0.19072031240369 6.41610973328726e-47 5 992 True False 0 0 0 0 0 0 0 2.28893824455566 2.04514637299001 2.56177017781099 0.0398406374501992 0.0270389239398186 0.0563886958557565 0.651818038721863 0.639957184433637 0.663539364797474 6723 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Ile245Val ccsA_p.Ile245Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 5 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Ile63Val ccsA_p.Ile63Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 227.636869136849 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Leu279Val ccsA_p.Leu279Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1704 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Leu317Val ccsA_p.Leu317Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1726 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Leu4Met ccsA_p.Leu4Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Met164Ile ccsA_p.Met164Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1727 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Phe186Ser ccsA_p.Phe186Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1722 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Phe237Leu ccsA_p.Phe237Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Phe237Ser ccsA_p.Phe237Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 31.2162477992404 1 193 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Phe242Leu ccsA_p.Phe242Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1723 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 944 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 6 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Phe305Val ccsA_p.Phe305Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Phe308Leu ccsA_p.Phe308Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1692 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Pro144Ser ccsA_p.Pro144Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 3546 20767 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 8.87492061244508 1 193 1879 False False 0 0 6.39361750002021 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 12 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Pro165Leu ccsA_p.Pro165Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Pro46Ser ccsA_p.Pro46Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1738 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Pro61Leu ccsA_p.Pro61Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 227.636869136849 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 29 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Pro71Leu ccsA_p.Pro71Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Ser193Asn ccsA_p.Ser193Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1713 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 941 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Ser283Ala ccsA_p.Ser283Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1717 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Thr19Ala ccsA_p.Thr19Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Thr19Pro ccsA_p.Thr19Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Thr200Ile ccsA_p.Thr200Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1728 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Thr224Pro ccsA_p.Thr224Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1690 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 932 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Thr232Ala ccsA_p.Thr232Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1718 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Thr266Ala ccsA_p.Thr266Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1730 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Thr314Ala ccsA_p.Thr314Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1739 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Thr3Met ccsA_p.Thr3Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 227.625948755393 1 617 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 4 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Thr56Ala ccsA_p.Thr56Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 31.21472012401 1 617 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 943 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 6 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Thr60Ile ccsA_p.Thr60Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Tyr111His ccsA_p.Tyr111His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1706 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Tyr134His ccsA_p.Tyr134His 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 16 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Tyr170Cys ccsA_p.Tyr170Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1694 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 933 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Tyr85Cys ccsA_p.Tyr85Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Val143Phe ccsA_p.Val143Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 5 3546 20767 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1720 1879 False False 0 0 6.39361750002021 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Val239Ile ccsA_p.Val239Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1714 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Val244Met ccsA_p.Val244Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Val27Ile ccsA_p.Val27Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 164 77 3382 20695 0.0462492949802594 0.03957226109313 0.0536865483231762 0.996293086847679 0.995369141138798 0.997073488160246 0.680497925311203 0.617596471139672 0.73889282085095 0.5 0.012579117093425 0.987420882906574 0.0128205128205128 0.000324534609097223 0.0693727407856049 6.11916026020106 0.0779313243403552 478.40583737484 0.261257661910087 88 1879 False False 13.0330166580905 9.85502361226287 17.3586261264187 0.000295595625184747 7.48380527561313e-06 0.00164584103069659 0.996293086847679 0.995369141138798 0.997073488160246 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 128 48 1479 6305 0.0796515245799626 0.0668799860935758 0.093982376608915 0.992444514402644 0.989994865954838 0.994424078584568 0.727272727272727 0.655156246551317 0.791562653670718 0.5 0.012579117093425 0.987420882906574 0.0204081632653061 0.000516556497593286 0.108541763968406 4.263015551048 0.0542716636654318 333.761164497239 0.34405709175156 46 992 False False 0 0 0 0 0 0 0 11.3680414694613 8.05259893520778 16.2608679358933 0.000675675675675675 1.71064806989024e-05 0.00375881469309733 0.992444514402644 0.989994865954838 0.994424078584568 376 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Val301Leu ccsA_p.Val301Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 227.636869136849 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Val6Phe ccsA_p.Val6Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1695 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin ccsA p.Val76Ile ccsA_p.Val76Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 227.636869136849 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin eis c.1023C>G eis_c.1023C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.105C>G eis_c.105C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.1068G>A eis_c.1068G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 6 3546 20766 0 0 0.0010397522169524 0.999711149624494 0.999371401166804 0.999893989862555 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.9758630843129 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.-10G>A eis_c.-10G>A 1 upstream_gene_variant 2715342 1 286 199 87 234 99 3312 20673 0.065989847715736 0.0580379760510498 0.0746659807577846 0.995233968804159 0.994200537428864 0.996124767327728 0.702702702702702 0.650457871324683 0.751299433953819 0.695804195804195 0.638901872615671 0.748595356902015 0.667785234899328 0.611160533931092 0.721034056886817 14.2773300849575 11.0127147802442 18.6260111561154 1.68082197064617e-100 3 1879 True False 14.7534584980237 11.5779817601135 18.9116273924458 0.0566790088293933 0.049259941805208 0.0648465396373172 0.995233968804159 0.994200537428864 0.996124767327728 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 135 105 30 129 39 1478 6314 0.0802738021157436 0.0674540314257104 0.0946504158366579 0.993861167952148 0.991617475477398 0.99563115533976 0.767857142857142 0.696599773597135 0.829415883975151 0.777777777777777 0.698210361386323 0.844765563888961 0.729166666666666 0.648862098490323 0.799790740748874 14.9519621109607 9.83350541922025 23.3282042021841 3.75886636538694e-48 4 992 True False 0 0 0 0 0 0 0 14.1304257312376 9.75357347973557 20.8566570158872 0.0663297536323436 0.0545683700040526 0.0797288413132122 0.993861167952148 0.991617475477398 0.99563115533976 262 Assoc w R Assoc w R 1) Assoc w R Can only confer resistance if genetically linked to a functional Eis No change yes A 1 +Kanamycin eis c.-10G>C eis_c.-10G>C 1 upstream_gene_variant 2715342 1 67 20 47 25 58 3521 20714 0.00705019740552735 0.0045675607285026 0.0103900021346201 0.997207779703447 0.996391883550761 0.997879088111795 0.301204819277108 0.205312356609584 0.411777327391489 0.298507462686567 0.192794578312429 0.422718795568791 0.256410256410256 0.164189719614018 0.367858243460692 2.50339905853632 1.40325819554785 4.31378503872207 0.0013456556268836 21 1879 False False 2.53577059808635 1.51766769131015 4.12420140976144 0.00564812199943518 0.00345333124556749 0.00870965080920638 0.997207779703447 0.996391883550761 0.997879088111795 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 19 8 11 9 17 1598 6336 0.00560049782202862 0.00256400651532502 0.0106047563737941 0.997324098850936 0.995719069008731 0.998440440224704 0.346153846153846 0.172144138005666 0.55667192604239 0.421052631578947 0.202521438977162 0.665002155988264 0.32 0.149495422613569 0.535000717497372 2.88360450563204 1.00496094860613 7.8843955232971 0.0381340664568805 21 992 False False 0 0 0 0 0 0 0 2.09909445630567 0.822766896557189 4.98949506565046 0.0049813200498132 0.00215295958860744 0.00979147485285802 0.997324098850936 0.995719069008731 0.998440440224704 19 3) Uncertain significance No change no 1 +Kanamycin eis c.1119C>T eis_c.1119C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.1122G>A eis_c.1122G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 7 3546 20765 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.06480602430196 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.1161C>T eis_c.1161C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 3545 20770 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999903716541498 0.99965223478104 0.999988339413789 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.92947813822284 0.0496406430315194 56.2247306595764 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.1173C>G eis_c.1173C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.1188C>T eis_c.1188C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.120G>T eis_c.120G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.-12C>A eis_c.-12C>A 1 upstream_gene_variant 2715344 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin eis c.12C>T eis_c.12C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.-12C>T eis_c.-12C>T 1 upstream_gene_variant 2715344 1 591 256 335 324 371 3222 20401 0.0913705583756345 0.0820856910519304 0.101335260702119 0.98213941844791 0.98024523021826 0.983896891671806 0.466187050359712 0.428591334017396 0.504070962941838 0.4331641285956 0.392789423902703 0.474209995363888 0.408293460925039 0.3695335200146 0.447921068918482 4.83861511807813 4.07742834667535 5.73483666406104 5.29352181354813e-67 5 1879 True False 5.52964206658736 4.72640089722613 6.46581233886717 0.073605520414031 0.0651446600661598 0.0827912028796726 0.98213941844791 0.98024523021826 0.983896891671806 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 283 168 115 207 140 1400 6213 0.128811449906658 0.112811206567344 0.146180867105614 0.977963167007712 0.974047469742316 0.981431026457731 0.596541786743515 0.542839424647933 0.64858192774069 0.593639575971731 0.533915817772291 0.651381141560547 0.545454545454545 0.488013596160171 0.602012853964262 6.4831304347826 5.04422310341428 8.35145159879896 3.2622043641732e-50 2 992 True False 0 0 0 0 0 0 0 6.5616887755102 5.22485509363937 8.25506652109133 0.107142857142857 0.0922614210420048 0.123512840503796 0.977963167007712 0.974047469742316 0.981431026457731 492 Assoc w R 1) Assoc w R No change yes 1 +Kanamycin eis c.-13A>G eis_c.-13A>G 1 upstream_gene_variant 2715345 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1474 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 791 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 6 3) Uncertain significance No change no 1 +Kanamycin eis c.144C>T eis_c.144C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.2177754884198 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.147C>G eis_c.147C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.150201697158088 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.-14C>T eis_c.-14C>T 1 upstream_gene_variant 2715346 1 101 88 13 249 61 3297 20711 0.0702199661590524 0.0620259141351874 0.0791307740404646 0.997063354515694 0.996229332737276 0.997752976902003 0.803225806451612 0.754539986263773 0.84600957143185 0.871287128712871 0.789957988794308 0.929649818526586 0.590604026845637 0.507146644057434 0.670384316336254 42.522759618301 23.5859039676548 83.0121289835804 4.27760769307958e-61 6 1879 True False 25.6419845164754 19.2494263486136 34.5995529055419 0.0259970457902511 0.0209013915771425 0.0319320681373769 0.997063354515694 0.996229332737276 0.997752976902003 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 51 42 9 129 33 1478 6320 0.0802738021157436 0.0674540314257104 0.0946504158366579 0.994805603651818 0.992712801685182 0.996421799060194 0.796296296296296 0.725992512020239 0.855437254026711 0.823529411764705 0.69127401388101 0.915991300196838 0.56 0.440582222033235 0.674532801984126 19.9548940009021 9.54262116201735 46.7084634852151 3.45712373474786e-22 6 992 True False 0 0 0 0 0 0 0 16.7154631565998 11.2709647946851 25.4074575650242 0.0276315789473684 0.0199853808327594 0.0371677594368363 0.994805603651818 0.992712801685182 0.996421799060194 148 Assoc w R Assoc w R Marker of R 1) Assoc w R Can only confer resistance if genetically linked to a functional Eis No change yes A 1 +Kanamycin eis c.159C>A eis_c.159C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.-15C>G eis_c.-15C>G 1 upstream_gene_variant 2715347 1 11 1 10 3 16 3543 20756 0.000846023688663282 0.000174504417422474 0.00247043033885164 0.999229732331985 0.998749434152838 0.999559663409708 0.157894736842105 0.0338262490017646 0.395784551266674 0.0909090909090909 0.00229897221381426 0.412779916988382 0.0588235294117647 0.00148817439126663 0.28688939666722 0.585831216483206 0.0134985751567801 4.1203612535368 1 617 1879 False False 1.09843353090601 0.204996128215496 3.84028655480137 0.00028216704288939 7.1438254941256e-06 0.00157112051380901 0.999229732331985 0.998749434152838 0.999559663409708 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 1 7 2 10 1605 6343 0.00124455507156191 0.000150756945780856 0.00448845844972244 0.99842594050055 0.997107159926049 0.999244927346731 0.166666666666666 0.0208625254600923 0.484137748685967 0.125 0.0031597235312519 0.526509670875206 0.0909090909090909 0.00229897221381426 0.412779916988382 0.564574988874054 0.0125227104434069 4.39984201542845 1 233 992 False False 0 0 0 0 0 0 0 0.790404984423676 0.0841273863348103 3.71398428903257 0.00062266500622665 1.57643888068998e-05 0.00346433358074439 0.99842594050055 0.997107159926049 0.999244927346731 23 3) Uncertain significance No change no 1 +Kanamycin eis c.-15C>T eis_c.-15C>T 1 upstream_gene_variant 2715347 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1451 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Kanamycin eis c.15G>A eis_c.15G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.-16G>A eis_c.-16G>A 1 upstream_gene_variant 2715348 1 1 0 1 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 227.636869136849 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin eis c.-16G>C eis_c.-16G>C 1 upstream_gene_variant 2715348 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1466 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin eis c.177C>T eis_c.177C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.189G>A eis_c.189G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.198T>C eis_c.198T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.1G>T eis_c.1G>T 1 initiator_codon_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.210G>C eis_c.210G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.210G>T eis_c.210G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 16 3546 20756 0 0 0.0010397522169524 0.999229732331985 0.998749434152838 0.999559663409708 0 0 0.205907214207822 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.51862445866705 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 6 1607 6347 0 0 0.0022928741555424 0.99905556430033 0.997945503023207 0.999653332387469 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.35786664322939 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.213G>T eis_c.213G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.216T>C eis_c.216T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.87534793394977 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.57085126512166 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.-21C>T eis_c.-21C>T 1 upstream_gene_variant 2715353 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Kanamycin eis c.225G>A eis_c.225G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.-23G>C eis_c.-23G>C 1 upstream_gene_variant 2715355 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin eis c.-23G>T eis_c.-23G>T 1 upstream_gene_variant 2715355 1 3 0 3 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 14.1782880202046 1 617 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.57085126512166 1 233 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 5 3) Uncertain significance No change no 1 +Kanamycin eis c.246C>G eis_c.246C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.27C>T eis_c.27C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.2177754884198 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.291G>A eis_c.291G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.-2C>A eis_c.-2C>A 1 upstream_gene_variant 2715334 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1462 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 787 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin eis c.-2C>T eis_c.-2C>T 1 upstream_gene_variant 2715334 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin eis c.324A>T eis_c.324A>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.150201697158088 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.336C>T eis_c.336C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.2177754884198 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.339T>C eis_c.339T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.-33A>G eis_c.-33A>G 1 upstream_gene_variant 2715365 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance No change no 1 +Kanamycin eis c.33C>T eis_c.33C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.351A>C eis_c.351A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.369C>A eis_c.369C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.378C>T eis_c.378C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 4 43 3542 20729 0.00112803158488437 0.000307433460438748 0.00288566784728404 0.99792990564221 0.997212598208705 0.998501469796055 0.0851063829787234 0.0236770921038977 0.203792696412533 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.544404028731632 0.141842167927373 1.49933735004001 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 3 24 1604 6329 0.00186683260734287 0.000385151348909821 0.00544589495836224 0.996222257201322 0.994384200008006 0.997578074772697 0.111111111111111 0.0235274543808539 0.291586924273551 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.493220074812967 0.0949584360209561 1.6273258447802 NA NA NA NA NA NA 74 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.-37G>T eis_c.-37G>T 1 upstream_gene_variant 2715369 1 139 116 23 182 39 3364 20733 0.0513254371122391 0.0442941360606271 0.0591075212264124 0.998122472559214 0.997434242728671 0.998664564276397 0.823529411764705 0.766751663230894 0.871400340089959 0.834532374100719 0.762134579349808 0.892121146882341 0.748387096774193 0.672471270853193 0.814555178782225 31.0839580209895 19.7053548612007 51.0414279476994 1.13894544861073e-74 4 1879 True False 28.7615933412604 20.2128513096395 41.8206140067914 0.0333333333333333 0.027620552132956 0.0398464926642883 0.998122472559214 0.997434242728671 0.998664564276397 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 106 91 15 143 24 1464 6329 0.088985687616677 0.0755143863926134 0.103979478472612 0.996222257201322 0.994384200008006 0.997578074772697 0.8562874251497 0.793753676179849 0.905699399822537 0.858490566037735 0.777362781133257 0.91858085093511 0.791304347826086 0.705578771035894 0.861471876408741 26.2267304189435 15.0277038975612 48.9083512555076 2.00598323930712e-49 3 992 True False 0 0 0 0 0 0 0 25.7583959471766 16.558577021871 41.7074304806307 0.0585209003215434 0.0473757497079519 0.071367015237079 0.996222257201322 0.994384200008006 0.997578074772697 279 Assoc w R 1) Assoc w R No change yes 1 +Kanamycin eis c.381C>G eis_c.381C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.-39A>C eis_c.-39A>C 1 upstream_gene_variant 2715371 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin eis c.418C>T eis_c.418C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.-42_-39delTTCA eis_c.-42_-39delTTCA 1 upstream_gene_variant 2715370 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin eis c.420G>A eis_c.420G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.2177754884198 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.42G>C eis_c.42G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 27 5 3519 20767 0.00761421319796954 0.00502363711934746 0.0110590800267931 0.999759291353745 0.999438356476751 0.999921838086342 0.84375 0.672121234317958 0.947249435597866 NA NA NA NA NA NA NA NA NA NA NA NA False False 31.8675191815856 12.083726559152 106.033758629191 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 10 0 1597 6353 0.00622277535780958 0.00298797623318756 0.0114140395320774 1 0.999419516970794 1 1 0.691502892181239 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 8.90231564837059 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.-43A>G eis_c.-43A>G 1 upstream_gene_variant 2715375 1 4 0 4 0 5 3546 20767 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 8.87492061244508 1 193 1879 False False 0 0 6.39361750002021 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.0580478247511 1 233 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 9 3) Uncertain significance New Uncertain no 0 +Kanamycin eis c.-44T>C eis_c.-44T>C 1 upstream_gene_variant 2715376 1 2 1 1 2 2 3544 20770 0.000564015792442188 6.83122290578968e-05 0.00203591855262226 0.999903716541498 0.99965223478104 0.999988339413789 0.5 0.067585986488543 0.932414013511457 0.5 0.012579117093425 0.987420882906574 0.333333333333333 0.00840375865961264 0.905700675949754 5.86060948081264 0.0746395180446294 458.276138188309 0.270328315130512 90 1879 False False 5.86060948081264 0.424646188620106 80.7055921553874 0.000282087447108603 7.14181031782542e-06 0.001570677606179 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Kanamycin eis c.45G>A eis_c.45G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.-50T>C eis_c.-50T>C 1 upstream_gene_variant 2715382 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin eis c.537C>T eis_c.537C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.-54_-37delGTCGTCGTAATATTCACG eis_c.-54_-37delGTCGTCGTAATATTCACG 1 upstream_gene_variant 2715368 1 2 1 1 1 1 3545 20771 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999951858270749 0.999731800967312 0.999998781157685 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 5.8592383638928 0.0746220616644107 458.169367733398 0.270378083801644 96 1879 False False 5.8592383638928 0.0746220616644107 458.169367733398 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 1606 6352 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.999842594050055 0.999123305664052 0.999996014834324 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 3.95516811955168 0.0503551805307198 309.72516523151 0.363031768971759 54 992 False False 0 0 0 0 0 0 0 3.95516811955168 0.0503551805307198 309.72516523151 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.999842594050055 0.999123305664052 0.999996014834324 3 3) Uncertain significance New Uncertain no 0 +Kanamycin eis c.549C>T eis_c.549C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.-54G>A eis_c.-54G>A 1 upstream_gene_variant 2715386 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Kanamycin eis c.57G>A eis_c.57G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.-61A>C eis_c.-61A>C 1 upstream_gene_variant 2715393 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin eis c.-61A>G eis_c.-61A>G 1 upstream_gene_variant 2715393 1 1 1 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.150201697158088 Inf 0.14581791265729 60 1879 False False Inf 0.150201697158088 Inf 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin eis c.630A>C eis_c.630A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.649T>C eis_c.649T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.87534793394977 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.57085126512166 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.660C>T eis_c.660C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 10 3546 20762 0 0 0.0010397522169524 0.99951858270749 0.999114835261082 0.999769118326375 0 0 0.30849710781876 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.61340113759526 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.663C>T eis_c.663C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.-66T>G eis_c.-66T>G 1 upstream_gene_variant 2715398 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin eis c.678C>T eis_c.678C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.2177754884198 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.679C>A eis_c.679C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.2177754884198 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.-67T>A eis_c.-67T>A 1 upstream_gene_variant 2715399 1 7 0 7 0 7 3546 20765 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 4.06480602430196 0.603472689124846 144 1879 False False 0 0 4.06480602430196 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin eis c.-69C>T eis_c.-69C>T 1 upstream_gene_variant 2715401 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Kanamycin eis c.-6G>T eis_c.-6G>T 1 upstream_gene_variant 2715338 1 4 1 3 2 3 3544 20769 0.000564015792442188 6.83122290578968e-05 0.00203591855262226 0.999855574812247 0.999577986903419 0.999970215063798 0.4 0.0527449505263169 0.853367200365326 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 1.95344243792325 0.0371998829165403 24.3529384851302 0.467579232966964 121 1879 False False 3.9068848758465 0.326178241465502 34.1071975590821 0.000282087447108603 7.14181031782542e-06 0.001570677606179 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 4 3) Uncertain significance No change no 1 +Kanamycin eis c.705A>G eis_c.705A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.2177754884198 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.-70T>C eis_c.-70T>C 1 upstream_gene_variant 2715402 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1444 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 772 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin eis c.723C>A eis_c.723C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 0 3544 20772 0.000564015792442188 6.83122290578968e-05 0.00203591855262226 1 0.99982242673208 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.10031452590981 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 2 0 1605 6353 0.00124455507156191 0.000150756945780856 0.00448845844972244 1 0.999419516970794 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.742689158362403 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.762G>A eis_c.762G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.792A>G eis_c.792A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.-79A>C eis_c.-79A>C 1 upstream_gene_variant 2715411 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin eis c.807C>T eis_c.807C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.813A>C eis_c.813A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.823T>C eis_c.823T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.2177754884198 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.831C>T eis_c.831C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 13 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.840C>G eis_c.840C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.850C>T eis_c.850C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.864C>G eis_c.864C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.864C>T eis_c.864C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.870C>T eis_c.870C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.894C>T eis_c.894C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.-8C>A eis_c.-8C>A 1 upstream_gene_variant 2715340 1 26 4 22 11 23 3535 20749 0.00310208685843203 0.0015495363119703 0.00554369603206677 0.998892740227229 0.998339027077604 0.999297966870435 0.323529411764705 0.173883427493921 0.505265300898504 0.153846153846153 0.0435634765389238 0.348678785535361 0.148148148148148 0.0418873964737672 0.337310864024244 1.06719814838626 0.267180679156221 3.14473238948129 0.784784028737345 163 1879 False False 2.80719512945083 1.23422963563512 6.00067499798055 0.00113026278609776 0.000308041715701625 0.0028913705481946 0.998892740227229 0.998339027077604 0.999297966870435 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 1 5 6 5 1601 6348 0.00373366521468575 0.00137138406067734 0.00810877842801138 0.999212970250275 0.99816429885228 0.999744405769873 0.545454545454545 0.233793597659345 0.832511905936292 0.166666666666666 0.00421074451448947 0.641234578997674 0.166666666666666 0.00421074451448947 0.641234578997674 0.793004372267332 0.016755896225058 7.09408608213204 1 233 992 False False 0 0 0 0 0 0 0 4.75802623360399 1.20783849679293 19.7291108499566 0.00062421972534332 1.58037502656714e-05 0.00347297126244177 0.999212970250275 0.99816429885228 0.999744405769873 13 3) Uncertain significance No change no 1 +Kanamycin eis c.-8C>T eis_c.-8C>T 1 upstream_gene_variant 2715340 1 9 2 7 4 7 3542 20765 0.00112803158488437 0.000307433460438748 0.00288566784728404 0.999663007895243 0.999305791518941 0.999864501305137 0.363636363636363 0.109263443819098 0.692095284988322 0.222222222222222 0.0281449734778982 0.600093573716312 0.222222222222222 0.0281449734778982 0.600093573716312 1.67500201661692 0.169691898398443 8.80232179770796 0.627958756980219 160 1879 False False 3.35000403323384 0.718701884878255 13.1861310847915 0.000564334085778781 6.83507841000175e-05 0.00203706664395484 0.999663007895243 0.999305791518941 0.999864501305137 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.0580478247511 1 233 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 2 3) Uncertain significance No change no 1 +Kanamycin eis c.-8delC eis_c.-8delC 1 upstream_gene_variant 2715339 1 7 6 1 6 1 3540 20771 0.00169204737732656 0.000621196730345483 0.00367920983862615 0.999951858270749 0.999731800967312 0.999998781157685 0.857142857142857 0.421276802956804 0.996389703138099 0.857142857142857 0.421276802956804 0.996389703138099 0.857142857142857 0.421276802956804 0.996389703138099 35.2050847457627 4.26881025504461 1604.55879204237 5.86809891481057e-05 16 1879 True False 35.2050847457627 4.26881025504461 1604.55879204237 0.00169204737732656 0.000621196730345483 0.00367920983862615 0.999951858270749 0.999731800967312 0.999998781157685 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance 1 4 4 0 4 0 1603 6353 0.00248911014312383 0.000678602218007884 0.00636074311848652 1 0.999419516970794 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 2.61263370519439 Inf 0.00165621209956365 13 992 False False 0 0 0 0 0 0 0 Inf 2.61263370519439 Inf 0.00248911014312383 0.000678602218007884 0.00636074311848652 1 0.999419516970794 1 5 Assoc w R Evidence from ALL dataset only 2) Assoc w R - Interim DOWN from AwR to AwRI yes ALL only 3 +Kanamycin eis c.906G>C eis_c.906G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.909C>T eis_c.909C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.912A>G eis_c.912A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.921G>A eis_c.921G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.933T>G eis_c.933T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.981C>G eis_c.981C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 14.1782880202046 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.57085126512166 NA NA NA NA NA NA 12 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.996G>A eis_c.996G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin eis c.-9T>C eis_c.-9T>C 1 upstream_gene_variant 2715341 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1472 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Kanamycin eis deletion eis_deletion 1 feature_ablation (see "Genomic_coordinates" sheet) 0 0 0 0 1 4 3545 20768 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999807433082996 0.99950702628237 0.999947529583666 0.2 0.00505076337946806 0.716417936118089 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1432 1879 False False 1.46459802538787 0.0297312351170663 14.8120229375093 0 0 0.00104004536542481 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 765 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 11 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations New Uncertain no B 0 +Kanamycin eis LoF eis_LoF 1 LoF (see "Genomic_coordinates" sheet) 1 163 5 158 16 207 3530 20565 0.0045121263395375 0.00258120283902408 0.00731709492834953 0.99003466204506 0.988589007566085 0.991340570400528 0.0717488789237668 0.0415644049978097 0.113902148872701 0.0306748466257668 0.0100335850544355 0.0701303528161239 0.0235849056603773 0.00770130215482492 0.0541781358068919 0.184360096102126 0.0590011453449784 0.439867735465295 1.85111348121871e-06 11 1879 True False 0.450301761300652 0.252328437311805 0.750056940858443 0.00141442715700141 0.000459415114544224 0.00329768884758526 0.99003466204506 0.988589007566085 0.991340570400528 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 45 5 40 12 56 1595 6297 0.0074673304293715 0.00386425744794583 0.0130075578193471 0.991185266803085 0.988568417912401 0.993334771123347 0.176470588235294 0.0946500142452479 0.287972838440716 0.111111111111111 0.0370766613071913 0.240535808495514 0.081967213114754 0.0271513603955559 0.181011911109798 0.493495297805642 0.151771449805475 1.25332849553922 0.189338541248733 30 992 False False 0 0 0 0 0 0 0 0.845991939095387 0.41173434635793 1.60150213345542 0.003125 0.0010154335335836 0.00727752102925205 0.991185266803085 0.988568417912401 0.993334771123347 NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations New Uncertain yes B 0 +Kanamycin eis p.Ala109Gly eis_p.Ala109Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance No change no 1 +Kanamycin eis p.Ala120Val eis_p.Ala120Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1450 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 778 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin eis p.Ala134fs eis_p.Ala134fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1439 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations No change no B 1 +Kanamycin eis p.Ala151Val eis_p.Ala151Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin eis p.Ala153Ser eis_p.Ala153Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin eis p.Ala206fs eis_p.Ala206fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 3544 20772 0.000564015792442188 6.83122290578968e-05 0.00203591855262226 1 0.99982242673208 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1427 1879 False False Inf 1.10031452590981 Inf 0 0 0.0010403386792448 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations New Uncertain no B 0 +Kanamycin eis p.Ala207Thr eis_p.Ala207Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1452 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 779 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 7 3) Uncertain significance New Uncertain no 0 +Kanamycin eis p.Ala21Glu eis_p.Ala21Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin eis p.Ala22Gly eis_p.Ala22Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 3545 20770 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999903716541498 0.99965223478104 0.999988339413789 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2267281142718 1 617 1879 False False 2.92947813822284 0.0496406430315194 56.2247306595764 0 0 0.00104004536542481 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Kanamycin eis p.Ala243Val eis_p.Ala243Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 7 3546 20765 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 0 0 0.409616397225003 0 0 0.521823750104981 0 0 0.409616397225003 0 0 6.39300177623657 1 193 1879 False False 0 0 4.06480602430196 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 767 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 6 3) Uncertain significance No change no 1 +Kanamycin eis p.Ala251Gly eis_p.Ala251Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 14.1782880202046 1 617 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.0580478247511 1 233 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 2 3) Uncertain significance No change no 1 +Kanamycin eis p.Ala304Val eis_p.Ala304Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 31.2162477992404 1 193 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 784 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance No change no 1 +Kanamycin eis p.Ala330Val eis_p.Ala330Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin eis p.Ala338Thr eis_p.Ala338Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin eis p.Ala370Ser eis_p.Ala370Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin eis p.Ala370Val eis_p.Ala370Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1467 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin eis p.Ala371Ser eis_p.Ala371Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Kanamycin eis p.Ala62Val eis_p.Ala62Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.150201697158088 Inf 0.14581791265729 60 1879 False False Inf 0.150201697158088 Inf 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin eis p.Ala86Val eis_p.Ala86Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 8.87534793394977 1 617 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin eis p.Ala99Val eis_p.Ala99Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin eis p.Arg106His eis_p.Arg106His 1 missense_variant (see "Genomic_coordinates" sheet) 1 31 1 30 1 41 3545 20731 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.998026189100712 0.997323245260261 0.998583198328699 0.0238095238095238 0.000602623301603574 0.125658557174992 0.032258064516129 0.000816370071846613 0.167021116230227 0.0238095238095238 0.000602623301603574 0.125658557174992 0.194931828866948 0.00478018464448464 1.1734319835613 0.0762577439221824 38 1879 False False 0.142633045512401 0.00352893207311831 0.841086139152361 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.998026189100712 0.997323245260261 0.998583198328699 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 6 1607 6347 0 0 0.0022928741555424 0.99905556430033 0.997945503023207 0.999653332387469 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 4.31431799871255 0.590295457027813 77 992 False False 0 0 0 0 0 0 0 0 0 3.35786664322939 0 0 0.0022928741555424 0.99905556430033 0.997945503023207 0.999653332387469 56 3) Uncertain significance No change no 1 +Kanamycin eis p.Arg212His eis_p.Arg212His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance No change no 1 +Kanamycin eis p.Arg227Gln eis_p.Arg227Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1440 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 771 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin eis p.Arg254Gln eis_p.Arg254Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Kanamycin eis p.Arg297Cys eis_p.Arg297Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Kanamycin eis p.Arg339Gln eis_p.Arg339Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance New Uncertain no 0 +Kanamycin eis p.Arg365fs eis_p.Arg365fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 227.636869136849 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations New Uncertain no B 0 +Kanamycin eis p.Arg376Cys eis_p.Arg376Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin eis p.Arg37Gln eis_p.Arg37Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin eis p.Arg37Gly eis_p.Arg37Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.150201697158088 Inf 0.14581791265729 60 1879 False False Inf 0.150201697158088 Inf 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.101367337197729 Inf 0.201884422110552 36.5 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin eis p.Arg49Cys eis_p.Arg49Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance No change no 1 +Kanamycin eis p.Arg92Cys eis_p.Arg92Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 2 3) Uncertain significance No change no 1 +Kanamycin eis p.Arg94Ser eis_p.Arg94Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin eis p.Asn373fs eis_p.Asn373fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1448 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 775 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations New Uncertain no B 0 +Kanamycin eis p.Asp152Asn eis_p.Asp152Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1441 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin eis p.Asp221Glu eis_p.Asp221Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin eis p.Asp260Tyr eis_p.Asp260Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin eis p.Asp26fs eis_p.Asp26fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1484 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations New Uncertain no B 0 +Kanamycin eis p.Asp26Tyr eis_p.Asp26Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin eis p.Asp273Ala eis_p.Asp273Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin eis p.Asp281Gly eis_p.Asp281Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 227.636869136849 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 796 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance No change no 1 +Kanamycin eis p.Asp344fs eis_p.Asp344fs 1 frameshift (see "Genomic_coordinates" sheet) 1 3 0 3 2 6 3544 20766 0.000564015792442188 6.83122290578968e-05 0.00203591855262226 0.999711149624494 0.999371401166804 0.999893989862555 0.25 0.0318540262499442 0.650855794412824 0 0 0.707598226178713 0 0 0.4592581264399 0 0 14.1842403486767 1 617 1879 False False 1.95316027088036 0.192700728066701 10.9300298288233 0 0 0.0010403386792448 0.999711149624494 0.999371401166804 0.999893989862555 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 3 1605 6350 0.00124455507156191 0.000150756945780856 0.00448845844972244 0.999527782150165 0.998620605323549 0.999902606737868 0.4 0.0527449505263169 0.853367200365326 0 0 0.975 0 0 0.707598226178713 0 0 153.954539049965 1 233 992 False False 0 0 0 0 0 0 0 2.63759086188992 0.220091038914179 23.0414149124911 0 0 0.0022957280374523 0.999527782150165 0.998620605323549 0.999902606737868 3 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations No change no B 1 +Kanamycin eis p.Asp354Asn eis_p.Asp354Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Kanamycin eis p.Asp354Glu eis_p.Asp354Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1449 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 776 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin eis p.Gln272* eis_p.Gln272* 1 stop_gained (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 14.1782880202046 1 617 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations No change no B 1 +Kanamycin eis p.Glu103Lys eis_p.Glu103Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1428 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin eis p.Glu10* eis_p.Glu10* 1 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1477 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 794 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 5 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations No change no B 1 +Kanamycin eis p.Glu122Gly eis_p.Glu122Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.0580478247511 1 233 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin eis p.Glu170* eis_p.Glu170* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations New Uncertain no B 0 +Kanamycin eis p.Glu176Ala eis_p.Glu176Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin eis p.Glu199Ala eis_p.Glu199Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.150201697158088 Inf 0.14581791265729 60 1879 False False Inf 0.150201697158088 Inf 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Kanamycin eis p.Glu313Asp eis_p.Glu313Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Kanamycin eis p.Glu316fs eis_p.Glu316fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 5 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations No change no B 1 +Kanamycin eis p.Glu348Asp eis_p.Glu348Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin eis p.Glu348Lys eis_p.Glu348Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 14.1782880202046 1 617 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance No change no 1 +Kanamycin eis p.Glu401Asp eis_p.Glu401Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 7 3546 20765 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 4.06480602430196 0.603472689124846 144 1879 False False 0 0 4.06480602430196 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.0580478247511 1 233 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 23 3) Uncertain significance No change no 1 +Kanamycin eis p.Glu74Asp eis_p.Glu74Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 227.636869136849 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 153.787547206498 1 233 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 3 3) Uncertain significance New Uncertain no 0 +Kanamycin eis p.Gly156Cys eis_p.Gly156Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin eis p.Gly159Asp eis_p.Gly159Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1453 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 780 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin eis p.Gly159fs eis_p.Gly159fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 3545 20771 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999951858270749 0.999731800967312 0.999998781157685 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1475 1879 False False 5.8592383638928 0.0746220616644107 458.169367733398 0 0 0.00104004536542481 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 792 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations New Uncertain no B 0 +Kanamycin eis p.Gly188Ala eis_p.Gly188Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 14.1782880202046 1 617 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin eis p.Gly209fs eis_p.Gly209fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1457 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 785 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations New Uncertain no B 0 +Kanamycin eis p.Gly210fs eis_p.Gly210fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 2 2 3544 20770 0.000564015792442188 6.83122290578968e-05 0.00203591855262226 0.999903716541498 0.99965223478104 0.999988339413789 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1436 1879 False False 5.86060948081264 0.424646188620106 80.7055921553874 0 0 0.0010403386792448 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations No change no B 1 +Kanamycin eis p.Gly222Ala eis_p.Gly222Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 3545 20771 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999951858270749 0.999731800967312 0.999998781157685 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 227.711777615967 1 617 1879 False False 5.8592383638928 0.0746220616644107 458.169367733398 0 0 0.00104004536542481 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 769 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 7 3) Uncertain significance No change no 1 +Kanamycin eis p.Gly222Arg eis_p.Gly222Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1470 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 789 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 21 3) Uncertain significance No change no 1 +Kanamycin eis p.Gly258Ser eis_p.Gly258Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin eis p.Gly309Asp eis_p.Gly309Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin eis p.Gly334fs eis_p.Gly334fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 3544 20772 0.000564015792442188 6.83122290578968e-05 0.00203591855262226 1 0.99982242673208 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.150244067202557 Inf 0.145782785705473 47 1879 False False Inf 1.10031452590981 Inf 0.000282087447108603 7.14181031782542e-06 0.001570677606179 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 1605 6353 0.00124455507156191 0.000150756945780856 0.00448845844972244 1 0.999419516970794 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.101430455199151 Inf 0.20178414373665 31.5 992 False False 0 0 0 0 0 0 0 Inf 0.742689158362403 Inf 0.00062266500622665 1.57643888068998e-05 0.00346433358074439 1 0.999419516970794 1 NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations New Uncertain no B 0 +Kanamycin eis p.Gly357Asp eis_p.Gly357Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin eis p.Gly357Ser eis_p.Gly357Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin eis p.His105Tyr eis_p.His105Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Kanamycin eis p.His150fs eis_p.His150fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 2 8 3544 20764 0.000564015792442188 6.83122290578968e-05 0.00203591855262226 0.999614866165992 0.999241274614236 0.99983371235125 0.2 0.0252107263268333 0.556095462307641 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1454 1879 False False 1.46472911963882 0.151439261401278 7.34364495908934 0 0 0.0010403386792448 0.999614866165992 0.999241274614236 0.99983371235125 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 4 1605 6349 0.00124455507156191 0.000150756945780856 0.00448845844972244 0.99937037620022 0.998388704765699 0.99982842290899 0.333333333333333 0.0432718682927417 0.777221904496487 NA NA NA 0 0 0.602364635616474 NA NA NA NA 781 992 False False 0 0 0 0 0 0 0 1.97788161993769 0.178739259054919 13.8135366697626 0 0 0.0022957280374523 0.99937037620022 0.998388704765699 0.99982842290899 11 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations No change no B 1 +Kanamycin eis p.His270Gln eis_p.His270Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 11 0 11 1 14 3545 20758 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999326015790487 0.998869427329123 0.999631479131688 0.0666666666666666 0.0016864302413527 0.319484566578303 0 0 0.284914152918154 0 0 0.231635761650116 0 0 2.33426552016919 0.385115723879213 116 1879 False False 0.418255087648599 0.00989216454442892 2.7507499999788 0 0 0.00104004536542481 0.999326015790487 0.998869427329123 0.999631479131688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 21.0547398420152 1 233 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 18 3) Uncertain significance No change no 1 +Kanamycin eis p.His277Tyr eis_p.His277Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 2 3) Uncertain significance New Uncertain no 0 +Kanamycin eis p.Ile267Thr eis_p.Ile267Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1430 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin eis p.Ile298fs eis_p.Ile298fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1459 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations No change no B 1 +Kanamycin eis p.Ile333Val eis_p.Ile333Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 3545 20771 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999951858270749 0.999731800967312 0.999998781157685 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1488 1879 False False 5.8592383638928 0.0746220616644107 458.169367733398 0 0 0.00104004536542481 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 2 1 1 1 1 1606 6352 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.999842594050055 0.999123305664052 0.999996014834324 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 3.95516811955168 0.0503551805307198 309.72516523151 0.363031768971759 54 992 False False 0 0 0 0 0 0 0 3.95516811955168 0.0503551805307198 309.72516523151 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.999842594050055 0.999123305664052 0.999996014834324 14 3) Uncertain significance New Uncertain no 0 +Kanamycin eis p.Leu140Val eis_p.Leu140Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin eis p.Leu158fs eis_p.Leu158fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1445 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 773 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations New Uncertain no B 0 +Kanamycin eis p.Leu18Arg eis_p.Leu18Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1485 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 798 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 NA 3) Uncertain significance No change no 1 +Kanamycin eis p.Leu18Pro eis_p.Leu18Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin eis p.Leu191fs eis_p.Leu191fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1458 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations No change no B 1 +Kanamycin eis p.Leu19Met eis_p.Leu19Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin eis p.Leu200Val eis_p.Leu200Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin eis p.Leu201Arg eis_p.Leu201Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin eis p.Leu235Arg eis_p.Leu235Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 3 3 3543 20769 0.000846023688663282 0.000174504417422474 0.00247043033885164 0.999855574812247 0.999577986903419 0.999970215063798 0.5 0.118117248757025 0.881882751242974 0.5 0.012579117093425 0.987420882906574 0.25 0.00630946320970987 0.805879550316756 5.86198137171888 0.0746569842760916 458.382968699616 0.270278536573795 89 1879 False False 5.86198137171888 0.784738114890132 43.7964492457281 0.00028216704288939 7.1438254941256e-06 0.00157112051380901 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 777 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance No change no 1 +Kanamycin eis p.Leu256Met eis_p.Leu256Met 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 2 3545 20770 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999903716541498 0.99965223478104 0.999988339413789 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1446 1879 False False 2.92947813822284 0.0496406430315194 56.2247306595764 0 0 0.00104004536542481 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 2 1606 6351 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.99968518810011 0.99886325869706 0.999961872544366 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 774 992 False False 0 0 0 0 0 0 0 1.97727272727272 0.0334940093351611 38.0316888278718 0 0 0.00229430020901157 0.99968518810011 0.99886325869706 0.999961872544366 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin eis p.Leu256Pro eis_p.Leu256Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1463 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Kanamycin eis p.Leu331Arg eis_p.Leu331Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 3545 20771 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999951858270749 0.999731800967312 0.999998781157685 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1464 1879 False False 5.8592383638928 0.0746220616644107 458.169367733398 0 0 0.00104004536542481 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin eis p.Leu361Phe eis_p.Leu361Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1431 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 764 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin eis p.Leu375fs eis_p.Leu375fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1478 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations New Uncertain no B 0 +Kanamycin eis p.Leu375Ser eis_p.Leu375Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin eis p.Leu386Ile eis_p.Leu386Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1442 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Kanamycin eis p.Leu77Pro eis_p.Leu77Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin eis p.Lys205Asn eis_p.Lys205Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Kanamycin eis p.Lys234Asn eis_p.Lys234Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1433 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 766 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 NA 3) Uncertain significance No change no 1 +Kanamycin eis p.Lys234Glu eis_p.Lys234Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1482 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 797 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 1 3) Uncertain significance New Uncertain no 0 +Kanamycin eis p.Met1? eis_p.Met1? 1 start_lost (see "Genomic_coordinates" sheet) 1 0 0 0 0 6 3546 20766 0 0 0.0010397522169524 0.999711149624494 0.999371401166804 0.999893989862555 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1461 1879 False False 0 0 4.9758630843129 0 0 0.0010397522169524 0.999711149624494 0.999371401166804 0.999893989862555 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1607 6349 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 786 992 False False 0 0 0 0 0 0 0 0 0 5.99028746746614 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 6 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations No change no B 1 +Kanamycin eis p.Met100Val eis_p.Met100Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1460 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Kanamycin eis p.Met16fs eis_p.Met16fs 1 frameshift (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 14.1782880202046 1 617 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.0580478247511 1 233 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 4 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations No change no B 1 +Kanamycin eis p.Met351Val eis_p.Met351Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin eis p.Met65Ile eis_p.Met65Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance No change no 1 +Kanamycin eis p.Phe129Leu eis_p.Phe129Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 3545 20771 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999951858270749 0.999731800967312 0.999998781157685 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 227.711777615967 1 617 1879 False False 5.8592383638928 0.0746220616644107 458.169367733398 0 0 0.00104004536542481 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 770 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 1 3) Uncertain significance No change no 1 +Kanamycin eis p.Phe149Val eis_p.Phe149Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 14.1782880202046 1 617 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.0580478247511 1 233 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 5 3) Uncertain significance New Uncertain no 0 +Kanamycin eis p.Phe84Tyr eis_p.Phe84Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1486 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Kanamycin eis p.Pro114Gln eis_p.Pro114Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1437 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 768 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin eis p.Pro114Leu eis_p.Pro114Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1480 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin eis p.Pro14_Val301delinsLeu eis_p.Pro14_Val301delinsLeu 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1447 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin eis p.Pro187Arg eis_p.Pro187Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin eis p.Pro193Ser eis_p.Pro193Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 7 3546 20765 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 4.06480602430196 0.603472689124846 144 1879 False False 0 0 4.06480602430196 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 12 3) Uncertain significance No change no 1 +Kanamycin eis p.Pro208Leu eis_p.Pro208Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin eis p.Pro274Leu eis_p.Pro274Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin eis p.Pro276Ser eis_p.Pro276Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.0580478247511 1 233 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 NA 3) Uncertain significance No change no 1 +Kanamycin eis p.Pro302Gln eis_p.Pro302Gln 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.150201697158088 Inf 0.14581791265729 60 1879 False False Inf 0.150201697158088 Inf 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin eis p.Pro30His eis_p.Pro30His 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 14.1782880202046 1 617 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin eis p.Pro30Leu eis_p.Pro30Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Kanamycin eis p.Pro342Leu eis_p.Pro342Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 16 0 16 1 16 3545 20756 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999229732331985 0.998749434152838 0.999559663409708 0.0588235294117647 0.00148817439126663 0.28688939666722 0 0 0.205907214207822 0 0 0.205907214207822 0 0 1.51905245995276 0.151711479237415 77 1879 False False 0.365937940761636 0.0087270836763684 2.35702922548854 0 0 0.00104004536542481 0.999229732331985 0.998749434152838 0.999559663409708 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 1607 6348 0 0 0.0022928741555424 0.999212970250275 0.99816429885228 0.999744405769873 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.31499754664604 0.590294849013717 75 992 False False 0 0 0 0 0 0 0 0 0 4.31499754664604 0 0 0.0022928741555424 0.999212970250275 0.99816429885228 0.999744405769873 11 3) Uncertain significance New Uncertain no 0 +Kanamycin eis p.Pro72Leu eis_p.Pro72Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin eis p.Pro78Ser eis_p.Pro78Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Kanamycin eis p.Pro89Leu eis_p.Pro89Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin eis p.Ser162fs eis_p.Ser162fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1434 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations New Uncertain no B 0 +Kanamycin eis p.Ser23Gly eis_p.Ser23Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin eis p.Ser318fs eis_p.Ser318fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations No change no B 1 +Kanamycin eis p.Ser367Pro eis_p.Ser367Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin eis p.Ser56Cys eis_p.Ser56Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin eis p.Ser56Pro eis_p.Ser56Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin eis p.Ser83Thr eis_p.Ser83Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin eis p.Thr136Ser eis_p.Thr136Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance No change no 1 +Kanamycin eis p.Thr231Ile eis_p.Thr231Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 8.87534793394977 1 617 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Kanamycin eis p.Thr269fs eis_p.Thr269fs 1 frameshift (see "Genomic_coordinates" sheet) 1 144 4 140 4 148 3542 20624 0.00112803158488437 0.000307433460438748 0.00288566784728404 0.992875024070864 0.991635437932324 0.993973480384446 0.0263157894736842 0.00721571460066601 0.0660061950600643 0.0277777777777777 0.00761928971562205 0.0695933665762236 0.0263157894736842 0.00721571460066601 0.0660061950600643 0.166362829716866 0.0446795913994501 0.435984389431004 4.27541131508332e-06 13 1879 True False 0.157370244326766 0.0422956582187076 0.411920669123289 0.00112803158488437 0.000307433460438748 0.00288566784728404 0.992875024070864 0.991635437932324 0.993973480384446 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 36 4 32 4 32 1603 6321 0.00248911014312383 0.000678602218007884 0.00636074311848652 0.994963009601763 0.992896649078137 0.996552227096515 0.111111111111111 0.0311161399450152 0.260610920510829 0.111111111111111 0.0311161399450152 0.260610920510829 0.111111111111111 0.0311161399450152 0.260610920510829 0.492903930131004 0.126464142471437 1.39287147660225 0.214139679851889 41 992 False False 0 0 0 0 0 0 0 0.492903930131004 0.126464142471437 1.39287147660225 0.00248911014312383 0.000678602218007884 0.00636074311848652 0.994963009601763 0.992896649078137 0.996552227096515 195 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations New Uncertain no B 0 +Kanamycin eis p.Thr282Ile eis_p.Thr282Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin eis p.Thr287Ala eis_p.Thr287Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1476 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 793 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 21 3) Uncertain significance No change no 1 +Kanamycin eis p.Thr2Ala eis_p.Thr2Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1479 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 795 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 1 3) Uncertain significance New Uncertain no 0 +Kanamycin eis p.Thr341Ala eis_p.Thr341Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1455 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 782 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin eis p.Thr341Ile eis_p.Thr341Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1483 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin eis p.Thr38Ala eis_p.Thr38Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Kanamycin eis p.Thr398Asn eis_p.Thr398Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 14.1782880202046 1 617 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Kanamycin eis p.Thr4Pro eis_p.Thr4Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 3545 20771 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999951858270749 0.999731800967312 0.999998781157685 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1465 1879 False False 5.8592383638928 0.0746220616644107 458.169367733398 0 0 0.00104004536542481 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin eis p.Thr70Ala eis_p.Thr70Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 3546 20767 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 6.39361750002021 1 617 1879 False False 0 0 6.39361750002021 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.57085126512166 1 233 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 72 3) Uncertain significance No change no 1 +Kanamycin eis p.Thr90fs eis_p.Thr90fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1468 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations No change no B 1 +Kanamycin eis p.Trp13Arg eis_p.Trp13Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1481 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin eis p.Trp182fs eis_p.Trp182fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1443 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations New Uncertain no B 0 +Kanamycin eis p.Trp182* eis_p.Trp182* 1 stop_gained (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations No change no B 1 +Kanamycin eis p.Trp253* eis_p.Trp253* 1 stop_gained (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1429 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations New Uncertain no B 0 +Kanamycin eis p.Trp36Arg eis_p.Trp36Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 1 3543 20771 0.000846023688663282 0.000174504417422474 0.00247043033885164 0.999951858270749 0.999731800967312 0.999998781157685 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 227.839861795577 1 617 1879 False False 17.5876375952582 1.41144968084872 918.001314114865 0 0 0.00104063215855229 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 8 3) Uncertain significance No change no 1 +Kanamycin eis p.Trp36* eis_p.Trp36* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations No change no B 1 +Kanamycin eis p.Tyr226fs eis_p.Tyr226fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations New Uncertain no B 0 +Kanamycin eis p.Tyr64Gln eis_p.Tyr64Gln 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1489 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 800 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin eis p.Tyr64* eis_p.Tyr64* 1 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1487 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 799 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations New Uncertain no B 0 +Kanamycin eis p.Val115Ala eis_p.Val115Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Kanamycin eis p.Val163Ile eis_p.Val163Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 647 12 635 60 714 3486 20058 0.0169204737732656 0.012936297816481 0.0217269527588894 0.965626805314846 0.963059113851011 0.968063083889882 0.0775193798449612 0.0596739258937187 0.0986590286381016 0.0185471406491499 0.00961938607226156 0.0321738182116236 0.0165289256198347 0.00856915312993413 0.0286945565942338 0.108734600945966 0.0558188456079409 0.191571441907629 3.88850793897723e-29 NA NA False True 0.483518708688294 0.364252628065692 0.631556431321793 0.00343053173241852 0.00177382350412085 0.00598477293538214 0.965626805314846 0.963059113851011 0.968063083889882 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 82 1 81 7 98 1600 6255 0.0043559427504667 0.00175305387776039 0.00895419084394721 0.984574216905399 0.981232702379426 0.98745933089034 0.0666666666666666 0.0272215964420653 0.132543271582352 0.0121951219512195 0.000308706096370227 0.0660827093893067 0.0101010101010101 0.000255702736665961 0.0549968231994302 0.0482638888888888 0.00121067492305373 0.277113799615336 2.62258309746033e-07 NA NA False True 0 1 1 0 0 1 0 0.279241071428571 0.109200078343546 0.59900880151564 0.000624609618988132 1.58136213620535e-05 0.00347513741720743 0.984574216905399 0.981232702379426 0.98745933089034 453 Not assoc w R 5) Not assoc w R No change yes 1 +Kanamycin eis p.Val301Gly eis_p.Val301Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1438 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Kanamycin eis p.Val301Ile eis_p.Val301Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 3546 20767 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 8.87492061244508 1 193 1879 False False 0 0 6.39361750002021 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Kanamycin eis p.Val314Leu eis_p.Val314Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 16 0 16 0 16 3546 20756 0 0 0.0010397522169524 0.999229732331985 0.998749434152838 0.999559663409708 0 0 0.205907214207822 0 0 0.205907214207822 0 0 0.205907214207822 0 0 1.51862445866705 0.151719879251819 78.5 1879 False False 0 0 1.51862445866705 0 0 0.0010397522169524 0.999229732331985 0.998749434152838 0.999559663409708 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 15 0 15 0 15 1607 6338 0 0 0.0022928741555424 0.997638910750826 0.996108727739866 0.998677932833021 0 0 0.218019360910534 0 0 0.218019360910534 0 0 0.218019360910534 0 0 1.10108282293089 0.052735698423258 24.5 992 False False 0 0 0 0 0 0 0 0 0 1.10108282293089 0 0 0.0022928741555424 0.997638910750826 0.996108727739866 0.998677932833021 7 3) Uncertain significance No change no 1 +Kanamycin eis p.Val396Ile eis_p.Val396Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1473 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin eis p.Val396Phe eis_p.Val396Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance No change no 1 +Kanamycin eis p.Val3Ala eis_p.Val3Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance No change no 1 +Kanamycin eis p.Val47fs eis_p.Val47fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1435 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations New Uncertain no B 0 +Kanamycin eis p.Val58Met eis_p.Val58Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1471 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 790 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin eis p.Val85Ala eis_p.Val85Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1456 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 783 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 NA 3) Uncertain significance No change no 1 +Kanamycin eis p.Val85fs eis_p.Val85fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 3545 20771 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999951858270749 0.999731800967312 0.999998781157685 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1469 1879 False False 5.8592383638928 0.0746220616644107 458.169367733398 0 0 0.00104004536542481 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 1606 6352 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.999842594050055 0.999123305664052 0.999996014834324 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 788 992 False False 0 0 0 0 0 0 0 3.95516811955168 0.0503551805307198 309.72516523151 0 0 0.00229430020901157 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance Abrogates effect of genetically linked AwR and AwRI eis mutations New Uncertain no B 0 +Kanamycin rrs n.1000G>A rrs_n.1000G>A 1 non_coding_transcript_exon_variant 1472845 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1411 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 747 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1001C>A rrs_n.1001C>A 1 non_coding_transcript_exon_variant 1472846 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1402 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 739 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1001C>G rrs_n.1001C>G 1 non_coding_transcript_exon_variant 1472846 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.1001C>T rrs_n.1001C>T 1 non_coding_transcript_exon_variant 1472846 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1149 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 505 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1002G>A rrs_n.1002G>A 1 non_coding_transcript_exon_variant 1472847 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1165 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 520 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1002G>C rrs_n.1002G>C 1 non_coding_transcript_exon_variant 1472847 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1251 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 599 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1002G>T rrs_n.1002G>T 1 non_coding_transcript_exon_variant 1472847 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1271 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 617 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1003T>A rrs_n.1003T>A 1 non_coding_transcript_exon_variant 1472848 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1174 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 528 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1003T>C rrs_n.1003T>C 1 non_coding_transcript_exon_variant 1472848 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1175 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 529 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1004C>G rrs_n.1004C>G 1 non_coding_transcript_exon_variant 1472849 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1286 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 632 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1005T>C rrs_n.1005T>C 1 non_coding_transcript_exon_variant 1472850 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1391 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 729 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1008A>C rrs_n.1008A>C 1 non_coding_transcript_exon_variant 1472853 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.-101_-100insG rrs_n.-101_-100insG 1 upstream_gene_variant 1471745 1 5 0 5 0 5 3546 20767 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 6.39361750002021 1 617 1879 False False 0 0 6.39361750002021 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 5 3) Uncertain significance No change no 1 +Kanamycin rrs n.1010_1011insC rrs_n.1010_1011insC 1 non_coding_transcript_exon_variant 1472855 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1011T>C rrs_n.1011T>C 1 non_coding_transcript_exon_variant 1472856 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.1012A>G rrs_n.1012A>G 1 non_coding_transcript_exon_variant 1472857 1 2 0 2 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 31.2162477992404 1 193 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 153.787547206498 1 233 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 19 3) Uncertain significance No change no 1 +Kanamycin rrs n.1013G>T rrs_n.1013G>T 1 non_coding_transcript_exon_variant 1472858 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1349 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 691 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 2 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1014_1015insA rrs_n.1014_1015insA 1 non_coding_transcript_exon_variant 1472859 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1150 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 506 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1014G>T rrs_n.1014G>T 1 non_coding_transcript_exon_variant 1472859 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1211 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 561 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1015C>G rrs_n.1015C>G 1 non_coding_transcript_exon_variant 1472860 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1048 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 413 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1015C>T rrs_n.1015C>T 1 non_coding_transcript_exon_variant 1472860 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1038 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 403 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1016G>A rrs_n.1016G>A 1 non_coding_transcript_exon_variant 1472861 1 1 0 1 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 227.636869136849 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 404 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.1016G>C rrs_n.1016G>C 1 non_coding_transcript_exon_variant 1472861 1 1 0 1 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 227.625948755393 1 617 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Kanamycin rrs n.1016G>T rrs_n.1016G>T 1 non_coding_transcript_exon_variant 1472861 1 1 0 1 1 1 3545 20771 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999951858270749 0.999731800967312 0.999998781157685 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 227.711777615967 1 617 1879 False False 5.8592383638928 0.0746220616644107 458.169367733398 0 0 0.00104004536542481 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Kanamycin rrs n.1017T>C rrs_n.1017T>C 1 non_coding_transcript_exon_variant 1472862 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1039 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 405 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1018T>C rrs_n.1018T>C 1 non_coding_transcript_exon_variant 1472863 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1252 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 600 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1021C>T rrs_n.1021C>T 1 non_coding_transcript_exon_variant 1472866 1 10 0 10 0 12 3546 20760 0 0 0.0010397522169524 0.999422299248989 0.998991090727643 0.999701459098715 0 0 0.264648469397051 0 0 0.30849710781876 0 0 0.264648469397051 0 0 2.61314943449954 0.375740360896329 110 1879 False False 0 0 2.1081669380099 0 0 0.0010397522169524 0.999422299248989 0.998991090727643 0.999701459098715 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 153.76339448854 1 233 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 4 3) Uncertain significance No change no 1 +Kanamycin rrs n.1022_1032delTTGTGGCCTGTinsCTTCGGGGGACAAA rrs_n.1022_1032delTTGTGGCCTGTinsCTTCGGGGGACAAA 1 non_coding_transcript_exon_variant 1472867 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1350 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1022_1032delTTGTGGCCTGTinsCTTCGGGGGCAGA rrs_n.1022_1032delTTGTGGCCTGTinsCTTCGGGGGCAGA 1 non_coding_transcript_exon_variant 1472867 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1225 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1022T>G rrs_n.1022T>G 1 non_coding_transcript_exon_variant 1472867 1 7 0 7 0 7 3546 20765 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 4.06480602430196 0.603472689124846 144 1879 False False 0 0 4.06480602430196 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 7 1607 6346 0 0 0.0022928741555424 0.998898158350385 0.997731111129242 0.999556891392146 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 2.74289259224573 0.357346851251029 48.5 992 False False 0 0 0 0 0 0 0 0 0 2.74289259224573 0 0 0.0022928741555424 0.998898158350385 0.997731111129242 0.999556891392146 2 3) Uncertain significance No change no 1 +Kanamycin rrs n.1024_1032delGTGGCCTGTinsCGGGGGCAGA rrs_n.1024_1032delGTGGCCTGTinsCGGGGGCAGA 1 non_coding_transcript_exon_variant 1472869 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1392 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 730 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1027G>A rrs_n.1027G>A 1 non_coding_transcript_exon_variant 1472872 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Kanamycin rrs n.1028C>A rrs_n.1028C>A 1 non_coding_transcript_exon_variant 1472873 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.1028C>T rrs_n.1028C>T 1 non_coding_transcript_exon_variant 1472873 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1412 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 748 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 2 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1030T>G rrs_n.1030T>G 1 non_coding_transcript_exon_variant 1472875 1 1 0 1 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 227.615028370197 1 617 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 618 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 3 3) Uncertain significance No change no 1 +Kanamycin rrs n.1035_1036insA rrs_n.1035_1036insA 1 non_coding_transcript_exon_variant 1472880 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1081 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 443 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1035G>A rrs_n.1035G>A 1 non_coding_transcript_exon_variant 1472880 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1112 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 474 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 4 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1040T>C rrs_n.1040T>C 1 non_coding_transcript_exon_variant 1472885 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.1042G>C rrs_n.1042G>C 1 non_coding_transcript_exon_variant 1472887 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1151 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 507 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 25 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1050C>T rrs_n.1050C>T 1 non_coding_transcript_exon_variant 1472895 0 0 0 0 3 35 3543 20737 0.000846023688663282 0.000174504417422474 0.00247043033885164 0.998315039476218 0.997657399390305 0.998826091293338 0.0789473684210526 0.0165864758645295 0.213773291180618 NA NA NA 0 0 0.100032435572105 NA NA NA NA 1310 1879 False False 0.501681383815168 0.0986655757294429 1.5928130457863 0 0 0.00104063215855229 0.998315039476218 0.997657399390305 0.998826091293338 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 28 1606 6325 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.995592633401542 0.993636381028915 0.997069399007024 0.0344827586206896 0.000872646883579922 0.177644295488722 NA NA NA 0 0 0.123436118500263 NA NA NA NA 653 992 False False 0 0 0 0 0 0 0 0.140655577299412 0.00344145814946179 0.852227255378434 0 0 0.00229430020901157 0.995592633401542 0.993636381028915 0.997069399007024 314 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1058A>G rrs_n.1058A>G 1 non_coding_transcript_exon_variant 1472903 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.1062C>T rrs_n.1062C>T 1 non_coding_transcript_exon_variant 1472907 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.1064T>C rrs_n.1064T>C 1 non_coding_transcript_exon_variant 1472909 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1067C>T rrs_n.1067C>T 1 non_coding_transcript_exon_variant 1472912 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1191 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1072G>A rrs_n.1072G>A 1 non_coding_transcript_exon_variant 1472917 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1176 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1077dupT rrs_n.1077dupT 1 non_coding_transcript_exon_variant 1472920 1 2 0 2 3 2 3543 20770 0.000846023688663282 0.000174504417422474 0.00247043033885164 0.999903716541498 0.99965223478104 0.999988339413789 0.6 0.146632799634673 0.947255049473683 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2446499681773 1 617 1879 False False 8.79339542760372 1.00678482242299 105.331235646919 0 0 0.00104063215855229 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 1604 6353 0.00186683260734287 0.000385151348909821 0.00544589495836224 1 0.999419516970794 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 654 992 False False 0 0 0 0 0 0 0 Inf 1.63477030328606 Inf 0 0 0.00229715764418053 1 0.999419516970794 1 NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.1078G>A rrs_n.1078G>A 1 non_coding_transcript_exon_variant 1472923 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1272 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 619 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1089C>A rrs_n.1089C>A 1 non_coding_transcript_exon_variant 1472934 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1226 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 574 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1089C>T rrs_n.1089C>T 1 non_coding_transcript_exon_variant 1472934 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1413 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 749 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1089dupC rrs_n.1089dupC 1 non_coding_transcript_exon_variant 1472931 0 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1259 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 606 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1090G>A rrs_n.1090G>A 1 non_coding_transcript_exon_variant 1472935 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1098C>A rrs_n.1098C>A 1 non_coding_transcript_exon_variant 1472943 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1099G>A rrs_n.1099G>A 1 non_coding_transcript_exon_variant 1472944 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1107_1118dupTGTCTCATGTTG rrs_n.1107_1118dupTGTCTCATGTTG 1 non_coding_transcript_exon_variant 1472951 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1107T>C rrs_n.1107T>C 1 non_coding_transcript_exon_variant 1472952 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1082 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 444 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 56 3) Uncertain significance No change no 1 +Kanamycin rrs n.1108_1109insA rrs_n.1108_1109insA 1 non_coding_transcript_exon_variant 1472953 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1062 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 426 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1108G>A rrs_n.1108G>A 1 non_coding_transcript_exon_variant 1472953 1 1 0 1 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 227.625948755393 1 617 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 731 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 5 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1109T>A rrs_n.1109T>A 1 non_coding_transcript_exon_variant 1472954 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1166 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1109T>C rrs_n.1109T>C 1 non_coding_transcript_exon_variant 1472954 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 38 3) Uncertain significance No change no 1 +Kanamycin rrs n.1110C>T rrs_n.1110C>T 1 non_coding_transcript_exon_variant 1472955 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1192 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 544 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 57 3) Uncertain significance No change no 1 +Kanamycin rrs n.1111T>C rrs_n.1111T>C 1 non_coding_transcript_exon_variant 1472956 1 0 0 0 0 7 3546 20765 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1027 1879 False False 0 0 4.06480602430196 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 1607 6347 0 0 0.0022928741555424 0.99905556430033 0.997945503023207 0.999653332387469 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 394 992 False False 0 0 0 0 0 0 0 0 0 3.35786664322939 0 0 0.0022928741555424 0.99905556430033 0.997945503023207 0.999653332387469 80 3) Uncertain significance No change no 1 +Kanamycin rrs n.1112_1114delCATinsTA rrs_n.1112_1114delCATinsTA 1 non_coding_transcript_exon_variant 1472957 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1049 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 414 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1112C>T rrs_n.1112C>T 1 non_coding_transcript_exon_variant 1472957 1 4 0 4 0 10 3546 20762 0 0 0.0010397522169524 0.99951858270749 0.999114835261082 0.999769118326375 0 0 0.30849710781876 0 0 0.602364635616474 0 0 0.30849710781876 0 0 8.8727840048859 1 617 1879 False False 0 0 2.61340113759526 0 0 0.0010397522169524 0.99951858270749 0.999114835261082 0.999769118326375 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 8 1607 6345 0 0 0.0022928741555424 0.99874075240044 0.997520296036287 0.99945619445686 0 0 0.369416647552819 0 0 0.602364635616474 0 0 0.369416647552819 0 0 5.98651822215824 0.589290182703008 62.5 992 False False 0 0 0 0 0 0 0 0 0 2.31577290672845 0 0 0.0022928741555424 0.99874075240044 0.997520296036287 0.99945619445686 80 3) Uncertain significance No change no 1 +Kanamycin rrs n.1113A>G rrs_n.1113A>G 1 non_coding_transcript_exon_variant 1472958 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1028 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 395 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 8 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1113A>T rrs_n.1113A>T 1 non_coding_transcript_exon_variant 1472958 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1333 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1114T>A rrs_n.1114T>A 1 non_coding_transcript_exon_variant 1472959 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1334 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1124A>G rrs_n.1124A>G 1 non_coding_transcript_exon_variant 1472969 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1298 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 641 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 6 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1125_1132delCGTAATGGinsTTCAGT rrs_n.1125_1132delCGTAATGGinsTTCAGT 1 non_coding_transcript_exon_variant 1472970 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1113 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 475 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1125C>A rrs_n.1125C>A 1 non_coding_transcript_exon_variant 1472970 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1203 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1125C>G rrs_n.1125C>G 1 non_coding_transcript_exon_variant 1472970 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1063 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 427 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 3 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1128A>G rrs_n.1128A>G 1 non_coding_transcript_exon_variant 1472973 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1299 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 642 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 40 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1128A>T rrs_n.1128A>T 1 non_coding_transcript_exon_variant 1472973 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1064 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 428 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 89 3) Uncertain significance No change no 1 +Kanamycin rrs n.1132G>C rrs_n.1132G>C 1 non_coding_transcript_exon_variant 1472977 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1083 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 445 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 3 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1133T>C rrs_n.1133T>C 1 non_coding_transcript_exon_variant 1472978 1 1 0 1 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 227.625948755393 1 617 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 675 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 6 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1137G>C rrs_n.1137G>C 1 non_coding_transcript_exon_variant 1472982 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1040 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 406 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1138A>C rrs_n.1138A>C 1 non_coding_transcript_exon_variant 1472983 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.0580478247511 1 233 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1141C>T rrs_n.1141C>T 1 non_coding_transcript_exon_variant 1472986 1 10 0 10 0 11 3546 20761 0 0 0.0010397522169524 0.99947044097824 0.999052670645628 0.99973561734751 0 0 0.284914152918154 0 0 0.30849710781876 0 0 0.284914152918154 0 0 2.61327528605106 0.375739646823095 109 1879 False False 0 0 2.33394419599086 0 0 0.0010397522169524 0.99947044097824 0.999052670645628 0.99973561734751 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Kanamycin rrs n.1142G>A rrs_n.1142G>A 1 non_coding_transcript_exon_variant 1472987 1 0 0 0 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1351 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1607 6349 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 692 992 False False 0 0 0 0 0 0 0 0 0 5.99028746746614 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 62 3) Uncertain significance No change no 1 +Kanamycin rrs n.1142G>T rrs_n.1142G>T 1 non_coding_transcript_exon_variant 1472987 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1253 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 601 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1143T>A rrs_n.1143T>A 1 non_coding_transcript_exon_variant 1472988 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1273 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 620 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1143T>C rrs_n.1143T>C 1 non_coding_transcript_exon_variant 1472988 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1335 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 676 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 9 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1144G>A rrs_n.1144G>A 1 non_coding_transcript_exon_variant 1472989 1 0 0 0 0 5 3546 20767 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1352 1879 False False 0 0 6.39361750002021 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 1607 6348 0 0 0.0022928741555424 0.999212970250275 0.99816429885228 0.999744405769873 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 693 992 False False 0 0 0 0 0 0 0 0 0 4.31499754664604 0 0 0.0022928741555424 0.999212970250275 0.99816429885228 0.999744405769873 49 3) Uncertain significance No change no 1 +Kanamycin rrs n.1145A>G rrs_n.1145A>G 1 non_coding_transcript_exon_variant 1472990 NA 0 0 0 0 7 3546 20765 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1353 1879 False True 0 0 4.06480602430196 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 7 1607 6346 0 0 0.0022928741555424 0.998898158350385 0.997731111129242 0.999556891392146 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 694 992 False True 0 1 1 0 0 0 0 0 0 2.74289259224573 0 0 0.0022928741555424 0.998898158350385 0.997731111129242 0.999556891392146 79 5) Not assoc w R UP from Uncertain to NotAwR yes 4 +Kanamycin rrs n.1147A>T rrs_n.1147A>T 1 non_coding_transcript_exon_variant 1472992 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1065 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 429 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1148_1149dupGA rrs_n.1148_1149dupGA 1 non_coding_transcript_exon_variant 1472988 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1148G>A rrs_n.1148G>A 1 non_coding_transcript_exon_variant 1472993 1 6 0 6 0 6 3546 20766 0 0 0.0010397522169524 0.999711149624494 0.999371401166804 0.999893989862555 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 4.9758630843129 0.60210064118223 134 1879 False False 0 0 4.9758630843129 0 0 0.0010397522169524 0.999711149624494 0.999371401166804 0.999893989862555 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 16 3) Uncertain significance No change no 1 +Kanamycin rrs n.1151T>C rrs_n.1151T>C 1 non_coding_transcript_exon_variant 1472996 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1414 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 750 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 15 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1153C>T rrs_n.1153C>T 1 non_coding_transcript_exon_variant 1472998 1 7 4 3 4 3 3542 20769 0.00112803158488437 0.000307433460438748 0.00288566784728404 0.999855574812247 0.999577986903419 0.999970215063798 0.571428571428571 0.184051567640083 0.901011721557492 0.571428571428571 0.184051567640083 0.901011721557492 0.571428571428571 0.184051567640083 0.901011721557492 7.81818181818181 1.32190864669878 53.4004081503056 0.0109191388520165 30 1879 False False 7.81818181818181 1.32190864669878 53.4004081503056 0.00112803158488437 0.000307433460438748 0.00288566784728404 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Kanamycin rrs n.1157G>T rrs_n.1157G>T 1 non_coding_transcript_exon_variant 1473002 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1133 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 493 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 5 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1159T>A rrs_n.1159T>A 1 non_coding_transcript_exon_variant 1473004 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1066 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 430 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 3 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.115A>G rrs_n.115A>G 1 non_coding_transcript_exon_variant 1471960 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1403 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.1161A>C rrs_n.1161A>C 1 non_coding_transcript_exon_variant 1473006 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1177 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1162A>C rrs_n.1162A>C 1 non_coding_transcript_exon_variant 1473007 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1260 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1163C>A rrs_n.1163C>A 1 non_coding_transcript_exon_variant 1473008 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1012 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 379 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1164T>A rrs_n.1164T>A 1 non_coding_transcript_exon_variant 1473009 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.1164T>C rrs_n.1164T>C 1 non_coding_transcript_exon_variant 1473009 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1212 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 562 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1166G>A rrs_n.1166G>A 1 non_coding_transcript_exon_variant 1473011 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1167G>A rrs_n.1167G>A 1 non_coding_transcript_exon_variant 1473012 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.1169G>C rrs_n.1169G>C 1 non_coding_transcript_exon_variant 1473014 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1227 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 575 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.116C>T rrs_n.116C>T 1 non_coding_transcript_exon_variant 1471961 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.1171A>C rrs_n.1171A>C 1 non_coding_transcript_exon_variant 1473016 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.1175dupT rrs_n.1175dupT 1 non_coding_transcript_exon_variant 1473019 0 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1366 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 705 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1176G>A rrs_n.1176G>A 1 non_coding_transcript_exon_variant 1473021 1 5 0 5 0 6 3546 20766 0 0 0.0010397522169524 0.999711149624494 0.999371401166804 0.999893989862555 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 6.39330963812699 1 617 1879 False False 0 0 4.9758630843129 0 0 0.0010397522169524 0.999711149624494 0.999371401166804 0.999893989862555 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Kanamycin rrs n.-117delT rrs_n.-117delT 1 upstream_gene_variant 1471728 1 2 0 2 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 31.2162477992404 1 193 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1180A>G rrs_n.1180A>G 1 non_coding_transcript_exon_variant 1473025 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1181T>C rrs_n.1181T>C 1 non_coding_transcript_exon_variant 1473026 1 0 0 0 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1204 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1607 6349 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 554 992 False False 0 0 0 0 0 0 0 0 0 5.99028746746614 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 4 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1184C>T rrs_n.1184C>T 1 non_coding_transcript_exon_variant 1473029 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1190G>A rrs_n.1190G>A 1 non_coding_transcript_exon_variant 1473035 0 0 0 0 3 33 3543 20739 0.000846023688663282 0.000174504417422474 0.00247043033885164 0.998411322934719 0.997769623498813 0.998906183277335 0.0833333333333333 0.0175264959239346 0.224689760556973 NA NA NA 0 0 0.105762810074579 NA NA NA NA 1067 1879 False False 0.532137633746439 0.104363555474284 1.69784451310347 0 0 0.00104063215855229 0.998411322934719 0.997769623498813 0.998906183277335 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 29 1606 6324 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.995435227451597 0.993450754193271 0.996940832844943 0.0333333333333333 0.000843570926630479 0.172169455633412 NA NA NA 0 0 0.119444869069502 NA NA NA NA 431 992 False False 0 0 0 0 0 0 0 0.135783913771632 0.00332630922044001 0.820366366851952 0 0 0.00229430020901157 0.995435227451597 0.993450754193271 0.996940832844943 306 3) Uncertain significance No change no 1 +Kanamycin rrs n.1191T>C rrs_n.1191T>C 1 non_coding_transcript_exon_variant 1473036 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.1198G>A rrs_n.1198G>A 1 non_coding_transcript_exon_variant 1473043 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1050 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 415 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1199C>G rrs_n.1199C>G 1 non_coding_transcript_exon_variant 1473044 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1404 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 740 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 24 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1199C>T rrs_n.1199C>T 1 non_coding_transcript_exon_variant 1473044 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Kanamycin rrs n.-119C>T rrs_n.-119C>T 1 upstream_gene_variant 1471727 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.11A>C rrs_n.11A>C 1 non_coding_transcript_exon_variant 1471856 0 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1393 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 732 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1208T>A rrs_n.1208T>A 1 non_coding_transcript_exon_variant 1473053 0 0 0 0 3 11 3543 20761 0.000846023688663282 0.000174504417422474 0.00247043033885164 0.99947044097824 0.999052670645628 0.99973561734751 0.214285714285714 0.0465792878898673 0.507975677048471 NA NA NA 0 0 0.284914152918154 NA NA NA NA 1205 1879 False False 1.59810638134092 0.286129216218252 6.05369020552991 0 0 0.00104063215855229 0.99947044097824 0.999052670645628 0.99973561734751 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 9 1606 6344 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.998583346450495 0.997312461277908 0.999352017626566 0.1 0.00252857854446178 0.445016117028195 NA NA NA 0 0 0.336267116879942 NA NA NA NA 555 992 False False 0 0 0 0 0 0 0 0.438909644389096 0.0100110022233902 3.17195020844629 0 0 0.00229430020901157 0.998583346450495 0.997312461277908 0.999352017626566 102 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1208T>C rrs_n.1208T>C 1 non_coding_transcript_exon_variant 1473053 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1261 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Kanamycin rrs n.1208T>G rrs_n.1208T>G 1 non_coding_transcript_exon_variant 1473053 1 3 0 3 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 14.1782880202046 1 617 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.0580478247511 1 233 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 24 3) Uncertain significance No change no 1 +Kanamycin rrs n.1210C>T rrs_n.1210C>T 1 non_coding_transcript_exon_variant 1473055 1 0 0 0 0 7 3546 20765 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1274 1879 False False 0 0 4.06480602430196 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 7 1607 6346 0 0 0.0022928741555424 0.998898158350385 0.997731111129242 0.999556891392146 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 621 992 False False 0 0 0 0 0 0 0 0 0 2.74289259224573 0 0 0.0022928741555424 0.998898158350385 0.997731111129242 0.999556891392146 125 3) Uncertain significance No change no 1 +Kanamycin rrs n.1211A>T rrs_n.1211A>T 1 non_coding_transcript_exon_variant 1473056 0 0 0 0 3 18 3543 20754 0.000846023688663282 0.000174504417422474 0.00247043033885164 0.999133448873483 0.998630820056588 0.999486348579758 0.142857142857142 0.0304889676215155 0.363423987016981 NA NA NA 0 0 0.185301968137852 NA NA NA NA 1134 1879 False False 0.976291278577476 0.184114243497144 3.34673339683267 0 0 0.00104063215855229 0.999133448873483 0.998630820056588 0.999486348579758 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 16 1606 6337 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.997481504800881 0.995913335169992 0.998559798442438 0.0588235294117647 0.00148817439126663 0.28688939666722 NA NA NA 0 0 0.205907214207822 NA NA NA NA 494 992 False False 0 0 0 0 0 0 0 0.246614259028642 0.00588077973628894 1.58990388049201 0 0 0.00229430020901157 0.997481504800881 0.995913335169992 0.998559798442438 194 3) Uncertain significance No change no 1 +Kanamycin rrs n.1217T>A rrs_n.1217T>A 1 non_coding_transcript_exon_variant 1473062 0 0 0 0 3 13 3543 20759 0.000846023688663282 0.000174504417422474 0.00247043033885164 0.999374157519738 0.998930028080923 0.99966672449503 0.1875 0.0404737339059459 0.456456546231611 NA NA NA 0 0 0.24705263800047 NA NA NA NA 1336 1879 False False 1.3521135934345 0.247014348103655 4.92433738571517 0 0 0.00104063215855229 0.999374157519738 0.998930028080923 0.99966672449503 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 11 1606 6342 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.998268534550606 0.996904046831145 0.999135351755422 0.0833333333333333 0.00210759323186022 0.384796165150944 NA NA NA 0 0 0.284914152918154 NA NA NA NA 677 992 False False 0 0 0 0 0 0 0 0.358994679044492 0.00833869553663541 2.4734928655095 0 0 0.00229430020901157 0.998268534550606 0.996904046831145 0.999135351755422 99 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1217T>G rrs_n.1217T>G 1 non_coding_transcript_exon_variant 1473062 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1213 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 563 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1220C>G rrs_n.1220C>G 1 non_coding_transcript_exon_variant 1473065 1 0 0 0 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1095 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 457 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.1221A>G rrs_n.1221A>G 1 non_coding_transcript_exon_variant 1473066 1 0 0 0 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1228 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1607 6349 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 576 992 False False 0 0 0 0 0 0 0 0 0 5.99028746746614 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 115 3) Uncertain significance No change no 1 +Kanamycin rrs n.1223A>G rrs_n.1223A>G 1 non_coding_transcript_exon_variant 1473068 0 0 0 0 3 15 3543 20757 0.000846023688663282 0.000174504417422474 0.00247043033885164 0.999277874061236 0.998809242329947 0.999595777053137 0.166666666666666 0.0357850831215746 0.414177491394774 NA NA NA 0 0 0.218019360910534 NA NA NA NA 1311 1879 False False 1.17171888230313 0.21731903178309 4.14510869911865 0 0 0.00104063215855229 0.999277874061236 0.998809242329947 0.999595777053137 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 13 1606 6340 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.997953722650716 0.996503345413809 0.998910007694291 0.0714285714285714 0.00180678065912538 0.338684489931821 NA NA NA 0 0 0.24705263800047 NA NA NA NA 655 992 False False 0 0 0 0 0 0 0 0.30366893380592 0.00714464649823022 2.02468686659141 0 0 0.00229430020901157 0.997953722650716 0.996503345413809 0.998910007694291 88 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1225G>A rrs_n.1225G>A 1 non_coding_transcript_exon_variant 1473070 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1096 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1229C>T rrs_n.1229C>T 1 non_coding_transcript_exon_variant 1473074 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1234G>A rrs_n.1234G>A 1 non_coding_transcript_exon_variant 1473079 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Kanamycin rrs n.1235C>A rrs_n.1235C>A 1 non_coding_transcript_exon_variant 1473080 1 0 0 0 0 6 3546 20766 0 0 0.0010397522169524 0.999711149624494 0.999371401166804 0.999893989862555 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1337 1879 False False 0 0 4.9758630843129 0 0 0.0010397522169524 0.999711149624494 0.999371401166804 0.999893989862555 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 1607 6347 0 0 0.0022928741555424 0.99905556430033 0.997945503023207 0.999653332387469 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 678 992 False False 0 0 0 0 0 0 0 0 0 3.35786664322939 0 0 0.0022928741555424 0.99905556430033 0.997945503023207 0.999653332387469 7 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1235C>G rrs_n.1235C>G 1 non_coding_transcript_exon_variant 1473080 0 0 0 0 1 2 3545 20770 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999903716541498 0.99965223478104 0.999988339413789 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1152 1879 False False 2.92947813822284 0.0496406430315194 56.2247306595764 0 0 0.00104004536542481 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 508 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1235C>T rrs_n.1235C>T 1 non_coding_transcript_exon_variant 1473080 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1135 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 495 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 15 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1236C>T rrs_n.1236C>T 1 non_coding_transcript_exon_variant 1473081 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1097 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 458 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 60 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1237G>A rrs_n.1237G>A 1 non_coding_transcript_exon_variant 1473082 0 0 0 0 1 7 3545 20765 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999663007895243 0.999305791518941 0.999864501305137 0.125 0.0031597235312519 0.526509670875206 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1068 1879 False False 0.836792262744307 0.0185616714978769 6.51673926470685 0 0 0.00104004536542481 0.999663007895243 0.999305791518941 0.999864501305137 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 1607 6347 0 0 0.0022928741555424 0.99905556430033 0.997945503023207 0.999653332387469 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 432 992 False False 0 0 0 0 0 0 0 0 0 3.35786664322939 0 0 0.0022928741555424 0.99905556430033 0.997945503023207 0.999653332387469 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1238G>T rrs_n.1238G>T 1 non_coding_transcript_exon_variant 1473083 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Kanamycin rrs n.1239T>A rrs_n.1239T>A 1 non_coding_transcript_exon_variant 1473084 0 0 0 0 1 6 3545 20766 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999711149624494 0.999371401166804 0.999893989862555 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1405 1879 False False 0.976304654442877 0.0212191705766405 8.05133152464184 0 0 0.00104004536542481 0.999711149624494 0.999371401166804 0.999893989862555 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 1607 6348 0 0 0.0022928741555424 0.999212970250275 0.99816429885228 0.999744405769873 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 741 992 False False 0 0 0 0 0 0 0 0 0 4.31499754664604 0 0 0.0022928741555424 0.999212970250275 0.99816429885228 0.999744405769873 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1239T>C rrs_n.1239T>C 1 non_coding_transcript_exon_variant 1473084 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 19 3) Uncertain significance No change no 1 +Kanamycin rrs n.1243A>G rrs_n.1243A>G 1 non_coding_transcript_exon_variant 1473088 1 1 0 1 0 6 3546 20766 0 0 0.0010397522169524 0.999711149624494 0.999371401166804 0.999893989862555 0 0 0.4592581264399 0 0 0.975 0 0 0.4592581264399 0 0 227.593187588584 1 193 1879 False False 0 0 4.9758630843129 0 0 0.0010397522169524 0.999711149624494 0.999371401166804 0.999893989862555 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 6 1607 6347 0 0 0.0022928741555424 0.99905556430033 0.997945503023207 0.999653332387469 0 0 0.4592581264399 0 0 0.975 0 0 0.4592581264399 0 0 153.690936225025 1 233 992 False False 0 0 0 0 0 0 0 0 0 3.35786664322939 0 0 0.0022928741555424 0.99905556430033 0.997945503023207 0.999653332387469 85 3) Uncertain significance No change no 1 +Kanamycin rrs n.1244A>G rrs_n.1244A>G 1 non_coding_transcript_exon_variant 1473089 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.1244A>T rrs_n.1244A>T 1 non_coding_transcript_exon_variant 1473089 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1069 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 433 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 3 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1246G>A rrs_n.1246G>A 1 non_coding_transcript_exon_variant 1473091 1 0 0 0 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1338 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1607 6349 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 679 992 False False 0 0 0 0 0 0 0 0 0 5.99028746746614 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 6 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1248C>G rrs_n.1248C>G 1 non_coding_transcript_exon_variant 1473093 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.1248C>T rrs_n.1248C>T 1 non_coding_transcript_exon_variant 1473093 1 0 0 0 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1013 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1607 6349 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 380 992 False False 0 0 0 0 0 0 0 0 0 5.99028746746614 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 68 3) Uncertain significance No change no 1 +Kanamycin rrs n.1249T>A rrs_n.1249T>A 1 non_coding_transcript_exon_variant 1473094 0 0 0 0 1 6 3545 20766 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999711149624494 0.999371401166804 0.999893989862555 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1070 1879 False False 0.976304654442877 0.0212191705766405 8.05133152464184 0 0 0.00104004536542481 0.999711149624494 0.999371401166804 0.999893989862555 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 1607 6348 0 0 0.0022928741555424 0.999212970250275 0.99816429885228 0.999744405769873 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 434 992 False False 0 0 0 0 0 0 0 0 0 4.31499754664604 0 0 0.0022928741555424 0.999212970250275 0.99816429885228 0.999744405769873 4 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.124T>C rrs_n.124T>C 1 non_coding_transcript_exon_variant 1471969 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1262 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 607 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1253A>G rrs_n.1253A>G 1 non_coding_transcript_exon_variant 1473098 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.1254T>A rrs_n.1254T>A 1 non_coding_transcript_exon_variant 1473099 0 0 0 0 1 7 3545 20765 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999663007895243 0.999305791518941 0.999864501305137 0.125 0.0031597235312519 0.526509670875206 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1041 1879 False False 0.836792262744307 0.0185616714978769 6.51673926470685 0 0 0.00104004536542481 0.999663007895243 0.999305791518941 0.999864501305137 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 1607 6347 0 0 0.0022928741555424 0.99905556430033 0.997945503023207 0.999653332387469 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 407 992 False False 0 0 0 0 0 0 0 0 0 3.35786664322939 0 0 0.0022928741555424 0.99905556430033 0.997945503023207 0.999653332387469 7 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1254T>G rrs_n.1254T>G 1 non_coding_transcript_exon_variant 1473099 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1178 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 530 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 5 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1255G>A rrs_n.1255G>A 1 non_coding_transcript_exon_variant 1473100 1 0 0 0 0 10 3546 20762 0 0 0.0010397522169524 0.99951858270749 0.999114835261082 0.999769118326375 0 0 0.30849710781876 NA NA NA 0 0 0.30849710781876 NA NA NA NA 1415 1879 False False 0 0 2.61340113759526 0 0 0.0010397522169524 0.99951858270749 0.999114835261082 0.999769118326375 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 10 1607 6343 0 0 0.0022928741555424 0.99842594050055 0.997107159926049 0.999244927346731 0 0 0.30849710781876 NA NA NA 0 0 0.30849710781876 NA NA NA NA 751 992 False False 0 0 0 0 0 0 0 0 0 1.76303467972913 0 0 0.0022928741555424 0.99842594050055 0.997107159926049 0.999244927346731 31 3) Uncertain significance No change no 1 +Kanamycin rrs n.1256C>T rrs_n.1256C>T 1 non_coding_transcript_exon_variant 1473101 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1257C>G rrs_n.1257C>G 1 non_coding_transcript_exon_variant 1473102 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.1257C>T rrs_n.1257C>T 1 non_coding_transcript_exon_variant 1473102 1 1 0 1 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 227.636869136849 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 706 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 41 3) Uncertain significance No change no 1 +Kanamycin rrs n.1259C>G rrs_n.1259C>G 1 non_coding_transcript_exon_variant 1473104 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.1259C>T rrs_n.1259C>T 1 non_coding_transcript_exon_variant 1473104 1 0 0 0 0 6 3546 20766 0 0 0.0010397522169524 0.999711149624494 0.999371401166804 0.999893989862555 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1238 1879 False False 0 0 4.9758630843129 0 0 0.0010397522169524 0.999711149624494 0.999371401166804 0.999893989862555 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 1607 6347 0 0 0.0022928741555424 0.99905556430033 0.997945503023207 0.999653332387469 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 586 992 False False 0 0 0 0 0 0 0 0 0 3.35786664322939 0 0 0.0022928741555424 0.99905556430033 0.997945503023207 0.999653332387469 33 3) Uncertain significance No change no 1 +Kanamycin rrs n.125G>A rrs_n.125G>A 1 non_coding_transcript_exon_variant 1471970 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1312 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 656 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 14 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.-125G>T rrs_n.-125G>T 1 upstream_gene_variant 1471721 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.1260G>A rrs_n.1260G>A 1 non_coding_transcript_exon_variant 1473105 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1416 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 752 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 4 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1264T>C rrs_n.1264T>C 1 non_coding_transcript_exon_variant 1473109 1 1 0 1 1 3 3545 20769 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999855574812247 0.999577986903419 0.999970215063798 0.25 0.00630946320970987 0.805879550316756 0 0 0.975 0 0 0.707598226178713 0 0 227.68993073963 1 193 1879 False False 1.95289139633286 0.0371893922070044 24.3461286113284 0 0 0.00104004536542481 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 153.787547206498 1 233 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 2 3) Uncertain significance No change no 1 +Kanamycin rrs n.1265T>G rrs_n.1265T>G 1 non_coding_transcript_exon_variant 1473110 1 0 0 0 0 7 3546 20765 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1354 1879 False False 0 0 4.06480602430196 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 7 1607 6346 0 0 0.0022928741555424 0.998898158350385 0.997731111129242 0.999556891392146 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 695 992 False False 0 0 0 0 0 0 0 0 0 2.74289259224573 0 0 0.0022928741555424 0.998898158350385 0.997731111129242 0.999556891392146 42 3) Uncertain significance No change no 1 +Kanamycin rrs n.1266A>G rrs_n.1266A>G 1 non_coding_transcript_exon_variant 1473111 1 0 0 0 0 7 3546 20765 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1098 1879 False False 0 0 4.06480602430196 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 7 1607 6346 0 0 0.0022928741555424 0.998898158350385 0.997731111129242 0.999556891392146 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 459 992 False False 0 0 0 0 0 0 0 0 0 2.74289259224573 0 0 0.0022928741555424 0.998898158350385 0.997731111129242 0.999556891392146 46 3) Uncertain significance No change no 1 +Kanamycin rrs n.126A>C rrs_n.126A>C 1 non_coding_transcript_exon_variant 1471971 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.1270G>C rrs_n.1270G>C 1 non_coding_transcript_exon_variant 1473115 0 0 0 0 1 7 3545 20765 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999663007895243 0.999305791518941 0.999864501305137 0.125 0.0031597235312519 0.526509670875206 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1379 1879 False False 0.836792262744307 0.0185616714978769 6.51673926470685 0 0 0.00104004536542481 0.999663007895243 0.999305791518941 0.999864501305137 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 1607 6347 0 0 0.0022928741555424 0.99905556430033 0.997945503023207 0.999653332387469 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 718 992 False False 0 0 0 0 0 0 0 0 0 3.35786664322939 0 0 0.0022928741555424 0.99905556430033 0.997945503023207 0.999653332387469 2 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1270G>T rrs_n.1270G>T 1 non_coding_transcript_exon_variant 1473115 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1042 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 408 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 11 3) Uncertain significance No change no 1 +Kanamycin rrs n.1274C>T rrs_n.1274C>T 1 non_coding_transcript_exon_variant 1473119 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1275C>T rrs_n.1275C>T 1 non_coding_transcript_exon_variant 1473120 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1275 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 622 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 6 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1276T>C rrs_n.1276T>C 1 non_coding_transcript_exon_variant 1473121 1 0 0 0 0 13 3546 20759 0 0 0.0010397522169524 0.999374157519738 0.998930028080923 0.99966672449503 0 0 0.24705263800047 NA NA NA 0 0 0.24705263800047 NA NA NA NA 1029 1879 False False 0 0 1.92188449077932 0 0 0.0010397522169524 0.999374157519738 0.998930028080923 0.99966672449503 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 12 1607 6341 0 0 0.0022928741555424 0.998111128600661 0.99670284884972 0.999023623643625 0 0 0.264648469397051 NA NA NA 0 0 0.264648469397051 NA NA NA NA 396 992 False False 0 0 0 0 0 0 0 0 0 1.42192958878239 0 0 0.0022928741555424 0.998111128600661 0.99670284884972 0.999023623643625 92 3) Uncertain significance No change no 1 +Kanamycin rrs n.1276T>G rrs_n.1276T>G 1 non_coding_transcript_exon_variant 1473121 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1071 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.1277T>A rrs_n.1277T>A 1 non_coding_transcript_exon_variant 1473122 1 0 0 0 0 9 3546 20763 0 0 0.0010397522169524 0.999566724436741 0.999177668076772 0.99980186029375 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1179 1879 False False 0 0 2.96786458045639 0 0 0.0010397522169524 0.999566724436741 0.999177668076772 0.99980186029375 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 7 1607 6346 0 0 0.0022928741555424 0.998898158350385 0.997731111129242 0.999556891392146 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 531 992 False False 0 0 0 0 0 0 0 0 0 2.74289259224573 0 0 0.0022928741555424 0.998898158350385 0.997731111129242 0.999556891392146 10 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1278A>C rrs_n.1278A>C 1 non_coding_transcript_exon_variant 1473123 1 0 0 0 0 5 3546 20767 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1287 1879 False False 0 0 6.39361750002021 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1607 6349 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 633 992 False False 0 0 0 0 0 0 0 0 0 5.99028746746614 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1278A>G rrs_n.1278A>G 1 non_coding_transcript_exon_variant 1473123 1 4 0 4 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 8.87534793394977 1 617 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 3) Uncertain significance No change no 1 +Kanamycin rrs n.1278A>T rrs_n.1278A>T 1 non_coding_transcript_exon_variant 1473123 1 0 0 0 0 5 3546 20767 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1114 1879 False False 0 0 6.39361750002021 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1607 6349 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 476 992 False False 0 0 0 0 0 0 0 0 0 5.99028746746614 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 64 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1278delAinsTC rrs_n.1278delAinsTC 1 non_coding_transcript_exon_variant 1473123 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1380 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 719 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1282G>A rrs_n.1282G>A 1 non_coding_transcript_exon_variant 1473127 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1339 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 680 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 4 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1282G>T rrs_n.1282G>T 1 non_coding_transcript_exon_variant 1473127 1 0 0 0 0 5 3546 20767 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1043 1879 False False 0 0 6.39361750002021 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1607 6349 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 409 992 False False 0 0 0 0 0 0 0 0 0 5.99028746746614 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1283C>T rrs_n.1283C>T 1 non_coding_transcript_exon_variant 1473128 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Kanamycin rrs n.1284C>T rrs_n.1284C>T 1 non_coding_transcript_exon_variant 1473129 1 0 0 0 0 7 3546 20765 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1044 1879 False False 0 0 4.06480602430196 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 1607 6347 0 0 0.0022928741555424 0.99905556430033 0.997945503023207 0.999653332387469 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 410 992 False False 0 0 0 0 0 0 0 0 0 3.35786664322939 0 0 0.0022928741555424 0.99905556430033 0.997945503023207 0.999653332387469 2 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1285G>A rrs_n.1285G>A 1 non_coding_transcript_exon_variant 1473130 1 1 0 1 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 227.625948755393 1 617 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 753 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 45 3) Uncertain significance No change no 1 +Kanamycin rrs n.1286G>T rrs_n.1286G>T 1 non_coding_transcript_exon_variant 1473131 1 0 0 0 0 6 3546 20766 0 0 0.0010397522169524 0.999711149624494 0.999371401166804 0.999893989862555 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1323 1879 False False 0 0 4.9758630843129 0 0 0.0010397522169524 0.999711149624494 0.999371401166804 0.999893989862555 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 1607 6348 0 0 0.0022928741555424 0.999212970250275 0.99816429885228 0.999744405769873 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 666 992 False False 0 0 0 0 0 0 0 0 0 4.31499754664604 0 0 0.0022928741555424 0.999212970250275 0.99816429885228 0.999744405769873 2 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1289T>C rrs_n.1289T>C 1 non_coding_transcript_exon_variant 1473134 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.1290C>T rrs_n.1290C>T 1 non_coding_transcript_exon_variant 1473135 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 2 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1300C>T rrs_n.1300C>T 1 non_coding_transcript_exon_variant 1473145 1 2 0 2 0 13 3546 20759 0 0 0.0010397522169524 0.999374157519738 0.998930028080923 0.99966672449503 0 0 0.24705263800047 0 0 0.841886116991581 0 0 0.24705263800047 0 0 31.2009716746149 1 617 1879 False False 0 0 1.92188449077932 0 0 0.0010397522169524 0.999374157519738 0.998930028080923 0.99966672449503 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 10 1607 6343 0 0 0.0022928741555424 0.99842594050055 0.997107159926049 0.999244927346731 0 0 0.30849710781876 NA NA NA 0 0 0.30849710781876 NA NA NA NA 532 992 False False 0 0 0 0 0 0 0 0 0 1.76303467972913 0 0 0.0022928741555424 0.99842594050055 0.997107159926049 0.999244927346731 145 3) Uncertain significance No change no 1 +Kanamycin rrs n.1302G>A rrs_n.1302G>A 1 non_coding_transcript_exon_variant 1473147 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 12 3) Uncertain significance No change no 1 +Kanamycin rrs n.1302G>C rrs_n.1302G>C 1 non_coding_transcript_exon_variant 1473147 0 0 0 0 2 8 3544 20764 0.000564015792442188 6.83122290578968e-05 0.00203591855262226 0.999614866165992 0.999241274614236 0.99983371235125 0.2 0.0252107263268333 0.556095462307641 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1167 1879 False False 1.46472911963882 0.151439261401278 7.34364495908934 0 0 0.0010403386792448 0.999614866165992 0.999241274614236 0.99983371235125 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 1607 6347 0 0 0.0022928741555424 0.99905556430033 0.997945503023207 0.999653332387469 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 521 992 False False 0 0 0 0 0 0 0 0 0 3.35786664322939 0 0 0.0022928741555424 0.99905556430033 0.997945503023207 0.999653332387469 8 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1302G>T rrs_n.1302G>T 1 non_coding_transcript_exon_variant 1473147 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1051 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 416 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 7 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1303G>A rrs_n.1303G>A 1 non_coding_transcript_exon_variant 1473148 0 0 0 0 2 9 3544 20763 0.000564015792442188 6.83122290578968e-05 0.00203591855262226 0.999566724436741 0.999177668076772 0.99980186029375 0.181818181818181 0.0228311982999596 0.517755852360172 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1136 1879 False False 1.30191873589164 0.136853683255704 6.29262336365321 0 0 0.0010403386792448 0.999566724436741 0.999177668076772 0.99980186029375 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 7 1607 6346 0 0 0.0022928741555424 0.998898158350385 0.997731111129242 0.999556891392146 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 496 992 False False 0 0 0 0 0 0 0 0 0 2.74289259224573 0 0 0.0022928741555424 0.998898158350385 0.997731111129242 0.999556891392146 18 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1305T>G rrs_n.1305T>G 1 non_coding_transcript_exon_variant 1473150 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1084 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 446 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 6 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.-130T>C rrs_n.-130T>C 1 upstream_gene_variant 1471716 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1316A>C rrs_n.1316A>C 1 non_coding_transcript_exon_variant 1473161 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1214 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 564 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 8 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1317C>T rrs_n.1317C>T 1 non_coding_transcript_exon_variant 1473162 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.1318C>T rrs_n.1318C>T 1 non_coding_transcript_exon_variant 1473163 0 0 0 0 1 9 3545 20763 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999566724436741 0.999177668076772 0.99980186029375 0.1 0.00252857854446178 0.445016117028195 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1085 1879 False False 0.650775740479548 0.0148464649376449 4.69895288822098 0 0 0.00104004536542481 0.999566724436741 0.999177668076772 0.99980186029375 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 7 1607 6346 0 0 0.0022928741555424 0.998898158350385 0.997731111129242 0.999556891392146 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 447 992 False False 0 0 0 0 0 0 0 0 0 2.74289259224573 0 0 0.0022928741555424 0.998898158350385 0.997731111129242 0.999556891392146 22 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1319C>A rrs_n.1319C>A 1 non_coding_transcript_exon_variant 1473164 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1313 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 657 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 9 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1319C>G rrs_n.1319C>G 1 non_coding_transcript_exon_variant 1473164 0 0 0 0 1 8 3545 20764 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999614866165992 0.999241274614236 0.99983371235125 0.111111111111111 0.00280913674659921 0.482496514917337 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1086 1879 False False 0.73215796897038 0.0164955563131374 5.46332200200716 0 0 0.00104004536542481 0.999614866165992 0.999241274614236 0.99983371235125 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 1607 6347 0 0 0.0022928741555424 0.99905556430033 0.997945503023207 0.999653332387469 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 448 992 False False 0 0 0 0 0 0 0 0 0 3.35786664322939 0 0 0.0022928741555424 0.99905556430033 0.997945503023207 0.999653332387469 7 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1320C>T rrs_n.1320C>T 1 non_coding_transcript_exon_variant 1473165 0 0 0 0 1 1 3545 20771 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999951858270749 0.999731800967312 0.999998781157685 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1324 1879 False False 5.8592383638928 0.0746220616644107 458.169367733398 0 0 0.00104004536542481 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 667 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance No change no 1 +Kanamycin rrs n.1321G>A rrs_n.1321G>A 1 non_coding_transcript_exon_variant 1473166 1 0 0 0 0 12 3546 20760 0 0 0.0010397522169524 0.999422299248989 0.998991090727643 0.999701459098715 0 0 0.264648469397051 NA NA NA 0 0 0.264648469397051 NA NA NA NA 1314 1879 False False 0 0 2.1081669380099 0 0 0.0010397522169524 0.999422299248989 0.998991090727643 0.999701459098715 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 11 1607 6342 0 0 0.0022928741555424 0.998268534550606 0.996904046831145 0.999135351755422 0 0 0.284914152918154 NA NA NA 0 0 0.284914152918154 NA NA NA NA 658 992 False False 0 0 0 0 0 0 0 0 0 1.57440756412985 0 0 0.0022928741555424 0.998268534550606 0.996904046831145 0.999135351755422 149 3) Uncertain significance No change no 1 +Kanamycin rrs n.1322T>G rrs_n.1322T>G 1 non_coding_transcript_exon_variant 1473167 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1323G>T rrs_n.1323G>T 1 non_coding_transcript_exon_variant 1473168 1 6 0 6 0 6 3546 20766 0 0 0.0010397522169524 0.999711149624494 0.999371401166804 0.999893989862555 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 4.9758630843129 0.60210064118223 134 1879 False False 0 0 4.9758630843129 0 0 0.0010397522169524 0.999711149624494 0.999371401166804 0.999893989862555 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance No change no 1 +Kanamycin rrs n.1327T>C rrs_n.1327T>C 1 non_coding_transcript_exon_variant 1473172 0 0 0 0 1 8 3545 20764 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999614866165992 0.999241274614236 0.99983371235125 0.111111111111111 0.00280913674659921 0.482496514917337 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1014 1879 False False 0.73215796897038 0.0164955563131374 5.46332200200716 0 0 0.00104004536542481 0.999614866165992 0.999241274614236 0.99983371235125 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 7 1607 6346 0 0 0.0022928741555424 0.998898158350385 0.997731111129242 0.999556891392146 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 381 992 False False 0 0 0 0 0 0 0 0 0 2.74289259224573 0 0 0.0022928741555424 0.998898158350385 0.997731111129242 0.999556891392146 19 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1327T>G rrs_n.1327T>G 1 non_coding_transcript_exon_variant 1473172 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 48 3) Uncertain significance No change no 1 +Kanamycin rrs n.1328C>T rrs_n.1328C>T 1 non_coding_transcript_exon_variant 1473173 1 1 0 1 1 11 3545 20761 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.99947044097824 0.999052670645628 0.99973561734751 0.0833333333333333 0.00210759323186022 0.384796165150944 0 0 0.975 0 0 0.284914152918154 0 0 227.602543084599 1 617 1879 False False 0.532401589947429 0.0123687722233094 3.66537636152503 0 0 0.00104004536542481 0.99947044097824 0.999052670645628 0.99973561734751 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 9 1607 6344 0 0 0.0022928741555424 0.998583346450495 0.997312461277908 0.999352017626566 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 707 992 False False 0 0 0 0 0 0 0 0 0 2.00246403812054 0 0 0.0022928741555424 0.998583346450495 0.997312461277908 0.999352017626566 62 3) Uncertain significance No change no 1 +Kanamycin rrs n.1332G>A rrs_n.1332G>A 1 non_coding_transcript_exon_variant 1473177 0 0 0 0 2 12 3544 20760 0.000564015792442188 6.83122290578968e-05 0.00203591855262226 0.999422299248989 0.998991090727643 0.999701459098715 0.142857142857142 0.0177945154831915 0.428129160909698 NA NA NA 0 0 0.264648469397051 NA NA NA NA 1193 1879 False False 0.976297968397291 0.106078818285766 4.38824189667154 0 0 0.0010403386792448 0.999422299248989 0.998991090727643 0.999701459098715 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 9 1607 6344 0 0 0.0022928741555424 0.998583346450495 0.997312461277908 0.999352017626566 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 545 992 False False 0 0 0 0 0 0 0 0 0 2.00246403812054 0 0 0.0022928741555424 0.998583346450495 0.997312461277908 0.999352017626566 158 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1334C>T rrs_n.1334C>T 1 non_coding_transcript_exon_variant 1473179 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1194 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 546 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 7 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1338A>C rrs_n.1338A>C 1 non_coding_transcript_exon_variant 1473183 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 NA NA False True 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 NA NA False True 0 0 0 0 0 1 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA Not assoc w R Not assoc w RI Previous WHO guidance 4) Not assoc w R - Interim No change yes Prev. WHO 1 +Kanamycin rrs n.133C>T rrs_n.133C>T 1 non_coding_transcript_exon_variant 1471978 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1153 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 509 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1341A>G rrs_n.1341A>G 1 non_coding_transcript_exon_variant 1473186 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1367 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.1346C>T rrs_n.1346C>T 1 non_coding_transcript_exon_variant 1473191 1 1 0 1 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 227.615028370197 1 617 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 547 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 29 3) Uncertain significance No change no 1 +Kanamycin rrs n.1347A>G rrs_n.1347A>G 1 non_coding_transcript_exon_variant 1473192 0 0 0 0 2 13 3544 20759 0.000564015792442188 6.83122290578968e-05 0.00203591855262226 0.999374157519738 0.998930028080923 0.99966672449503 0.133333333333333 0.0165759134400836 0.404602696603372 NA NA NA 0 0 0.24705263800047 NA NA NA NA 1087 1879 False False 0.901154714360132 0.0986889742493136 3.98329702983899 0 0 0.0010403386792448 0.999374157519738 0.998930028080923 0.99966672449503 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 9 1607 6344 0 0 0.0022928741555424 0.998583346450495 0.997312461277908 0.999352017626566 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 449 992 False False 0 0 0 0 0 0 0 0 0 2.00246403812054 0 0 0.0022928741555424 0.998583346450495 0.997312461277908 0.999352017626566 165 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1348G>A rrs_n.1348G>A 1 non_coding_transcript_exon_variant 1473193 1 4 0 4 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 8.87534793394977 1 617 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.134T>C rrs_n.134T>C 1 non_coding_transcript_exon_variant 1471979 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1276 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 623 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 3 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1356_1357delACinsT rrs_n.1356_1357delACinsT 1 non_coding_transcript_exon_variant 1473201 1 0 0 0 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1030 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 397 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 33 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1356_1360delACGCTinsTGCC rrs_n.1356_1360delACGCTinsTGCC 1 non_coding_transcript_exon_variant 1473201 0 0 0 0 2 9 3544 20763 0.000564015792442188 6.83122290578968e-05 0.00203591855262226 0.999566724436741 0.999177668076772 0.99980186029375 0.181818181818181 0.0228311982999596 0.517755852360172 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1340 1879 False False 1.30191873589164 0.136853683255704 6.29262336365321 0 0 0.0010403386792448 0.999566724436741 0.999177668076772 0.99980186029375 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 1607 6347 0 0 0.0022928741555424 0.99905556430033 0.997945503023207 0.999653332387469 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 681 992 False False 0 0 0 0 0 0 0 0 0 3.35786664322939 0 0 0.0022928741555424 0.99905556430033 0.997945503023207 0.999653332387469 28 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1356A>T rrs_n.1356A>T 1 non_coding_transcript_exon_variant 1473201 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1099 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 460 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1356delA rrs_n.1356delA 1 non_coding_transcript_exon_variant 1473199 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1100 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 461 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 136 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1357C>T rrs_n.1357C>T 1 non_coding_transcript_exon_variant 1473202 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1394 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 733 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 7 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1359C>T rrs_n.1359C>T 1 non_coding_transcript_exon_variant 1473204 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.-135G>T rrs_n.-135G>T 1 upstream_gene_variant 1471711 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1360T>C rrs_n.1360T>C 1 non_coding_transcript_exon_variant 1473205 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1137 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 497 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 156 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1361G>A rrs_n.1361G>A 1 non_coding_transcript_exon_variant 1473206 1 0 0 0 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1215 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 565 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 30 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1361G>C rrs_n.1361G>C 1 non_coding_transcript_exon_variant 1473206 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1367A>G rrs_n.1367A>G 1 non_coding_transcript_exon_variant 1473212 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.136C>T rrs_n.136C>T 1 non_coding_transcript_exon_variant 1471981 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1379G>A rrs_n.1379G>A 1 non_coding_transcript_exon_variant 1473224 1 11 0 11 0 11 3546 20761 0 0 0.0010397522169524 0.99947044097824 0.999052670645628 0.99973561734751 0 0 0.284914152918154 0 0 0.284914152918154 0 0 0.284914152918154 0 0 2.33394419599086 0.385127888074456 118 1879 False False 0 0 2.33394419599086 0 0 0.0010397522169524 0.99947044097824 0.999052670645628 0.99973561734751 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 1607 6347 0 0 0.0022928741555424 0.99905556430033 0.997945503023207 0.999653332387469 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.35786664322939 0.607610106306186 81 992 False False 0 0 0 0 0 0 0 0 0 3.35786664322939 0 0 0.0022928741555424 0.99905556430033 0.997945503023207 0.999653332387469 2 3) Uncertain significance No change no 1 +Kanamycin rrs n.1381C>T rrs_n.1381C>T 1 non_coding_transcript_exon_variant 1473226 1 0 0 0 0 6 3546 20766 0 0 0.0010397522169524 0.999711149624494 0.999371401166804 0.999893989862555 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1239 1879 False False 0 0 4.9758630843129 0 0 0.0010397522169524 0.999711149624494 0.999371401166804 0.999893989862555 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 587 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 47 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1382C>G rrs_n.1382C>G 1 non_coding_transcript_exon_variant 1473227 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.138C>T rrs_n.138C>T 1 non_coding_transcript_exon_variant 1471983 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1315 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 659 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.13A>G rrs_n.13A>G 1 non_coding_transcript_exon_variant 1471858 1 1 1 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.150201697158088 Inf 0.14581791265729 60 1879 False False Inf 0.150201697158088 Inf 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1401A>G rrs_n.1401A>G 1 non_coding_transcript_exon_variant 1473246 1 1570 1491 79 1666 100 1880 20672 0.469825155104342 0.453287829010829 0.486412277984569 0.995185827074908 0.994147726466681 0.996081331406835 0.943374858437146 0.931554553538262 0.95369324086622 0.94968152866242 0.937679980171214 0.959963045058701 0.937146448774355 0.924078571434591 0.948570591059317 207.527282520872 163.559748478721 265.789157707806 0 1 1879 True False 183.189106382978 148.924694118969 229.153096815428 0.442301987540789 0.425443929878348 0.459260237968791 0.995185827074908 0.994147726466681 0.996081331406835 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 609 575 34 664 43 943 6310 0.413192283758556 0.388983511326776 0.437718788067428 0.993231544152368 0.990893649568512 0.995097430478012 0.939179632248939 0.918946570426869 0.955637990163324 0.944170771756978 0.922854979035122 0.961030453134398 0.93042071197411 0.907418685497333 0.949190851680428 113.163558106169 79.3295178002985 165.836833031728 0 1 992 True False 0 0 0 0 0 0 0 103.327825593726 75.2176100696477 145.432512467472 0.378787878787878 0.354310649153707 0.403735099898746 0.993231544152368 0.990893649568512 0.995097430478012 950 Assoc w R Assoc w R Marker of R 1) Assoc w R No change yes 1 +Kanamycin rrs n.1402C>A rrs_n.1402C>A 1 non_coding_transcript_exon_variant 1473247 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1015 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 382 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 25 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1402C>T rrs_n.1402C>T 1 non_coding_transcript_exon_variant 1473247 1 11 6 5 10 6 3536 20766 0.00282007896221094 0.00135314014136576 0.00518009078773565 0.999711149624494 0.999371401166804 0.999893989862555 0.625 0.354346094302078 0.848016324918877 0.545454545454545 0.233793597659345 0.832511905936292 0.5 0.210944638239296 0.789055361760703 7.0472850678733 1.79060812588928 29.2106666705544 0.00227090214260828 23 1879 False False 9.78789592760181 3.22021396580097 32.8014547138931 0.00169395821569734 0.000621898528587714 0.00368336064808191 0.999711149624494 0.999371401166804 0.999893989862555 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 2 2 4 2 1603 6351 0.00248911014312383 0.000678602218007884 0.00636074311848652 0.99968518810011 0.99886325869706 0.999961872544366 0.666666666666666 0.222778095503512 0.956728131707258 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 3.96194635059263 0.286910943533706 54.6463186145293 0.183353503097679 29 992 False False 0 0 0 0 0 0 0 7.92389270118527 1.13411259454955 87.7838935728309 0.00124610591900311 0.000150944849281046 0.00449404244088155 0.99968518810011 0.99886325869706 0.999961872544366 18 Assoc w RI Marker of R WHO-endorsed gDST assay 2) Assoc w R - Interim No change yes WHO-end. gDST 1 +Kanamycin rrs n.1403G>A rrs_n.1403G>A 1 non_coding_transcript_exon_variant 1473248 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1240 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 588 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 7 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1404T>C rrs_n.1404T>C 1 non_coding_transcript_exon_variant 1473249 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1355 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 696 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 7 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1407T>C rrs_n.1407T>C 1 non_coding_transcript_exon_variant 1473252 NA 0 0 0 0 8 3546 20764 0 0 0.0010397522169524 0.999614866165992 0.999241274614236 0.99983371235125 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1277 1879 False True 0 0 3.43205141622579 0 0 0.0010397522169524 0.999614866165992 0.999241274614236 0.99983371235125 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 7 1607 6346 0 0 0.0022928741555424 0.998898158350385 0.997731111129242 0.999556891392146 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 624 992 False True 0 1 1 0 0 0 0 0 0 2.74289259224573 0 0 0.0022928741555424 0.998898158350385 0.997731111129242 0.999556891392146 78 5) Not assoc w R New NotAwR yes 5 +Kanamycin rrs n.1409A>G rrs_n.1409A>G 1 non_coding_transcript_exon_variant 1473254 1 3 0 3 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 14.1782880202046 1 617 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.140T>C rrs_n.140T>C 1 non_coding_transcript_exon_variant 1471985 1 0 0 0 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1356 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1607 6349 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 697 992 False False 0 0 0 0 0 0 0 0 0 5.99028746746614 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 4 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.140T>G rrs_n.140T>G 1 non_coding_transcript_exon_variant 1471985 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.0580478247511 1 233 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.1410A>G rrs_n.1410A>G 1 non_coding_transcript_exon_variant 1473255 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1254 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 602 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 4 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1413T>C rrs_n.1413T>C 1 non_coding_transcript_exon_variant 1473258 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1154 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 510 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1414C>T rrs_n.1414C>T 1 non_coding_transcript_exon_variant 1473259 1 0 0 0 0 6 3546 20766 0 0 0.0010397522169524 0.999711149624494 0.999371401166804 0.999893989862555 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1325 1879 False False 0 0 4.9758630843129 0 0 0.0010397522169524 0.999711149624494 0.999371401166804 0.999893989862555 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1607 6349 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 668 992 False False 0 0 0 0 0 0 0 0 0 5.99028746746614 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 83 3) Uncertain significance No change no 1 +Kanamycin rrs n.1415G>T rrs_n.1415G>T 1 non_coding_transcript_exon_variant 1473260 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1180 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1416G>A rrs_n.1416G>A 1 non_coding_transcript_exon_variant 1473261 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.-141A>G rrs_n.-141A>G 1 upstream_gene_variant 1471705 1 6 1 5 1 5 3545 20767 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999759291353745 0.999438356476751 0.999921838086342 0.166666666666666 0.00421074451448947 0.641234578997674 0.166666666666666 0.00421074451448947 0.641234578997674 0.166666666666666 0.00421074451448947 0.641234578997674 1.17162200282087 0.0247643691956443 10.4748703386698 1 617 1879 False False 1.17162200282087 0.0247643691956443 10.4748703386698 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999759291353745 0.999438356476751 0.999921838086342 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Kanamycin rrs n.141C>T rrs_n.141C>T 1 non_coding_transcript_exon_variant 1471986 1 2 0 2 0 7 3546 20765 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 0 0 0.409616397225003 0 0 0.841886116991581 0 0 0.409616397225003 0 0 31.2101371820114 1 617 1879 False False 0 0 4.06480602430196 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 6 1607 6347 0 0 0.0022928741555424 0.99905556430033 0.997945503023207 0.999653332387469 0 0 0.4592581264399 0 0 0.975 0 0 0.4592581264399 0 0 153.690936225025 1 233 992 False False 0 0 0 0 0 0 0 0 0 3.35786664322939 0 0 0.0022928741555424 0.99905556430033 0.997945503023207 0.999653332387469 9 3) Uncertain significance No change no 1 +Kanamycin rrs n.1425G>A rrs_n.1425G>A 1 non_coding_transcript_exon_variant 1473270 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Kanamycin rrs n.-142C>T rrs_n.-142C>T 1 upstream_gene_variant 1471704 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.142G>A rrs_n.142G>A 1 non_coding_transcript_exon_variant 1471987 1 8 0 8 0 8 3546 20764 0 0 0.0010397522169524 0.999614866165992 0.999241274614236 0.99983371235125 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 3.43205141622579 0.612907213659498 156 1879 False False 0 0 3.43205141622579 0 0 0.0010397522169524 0.999614866165992 0.999241274614236 0.99983371235125 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 5 3) Uncertain significance No change no 1 +Kanamycin rrs n.1431A>G rrs_n.1431A>G 1 non_coding_transcript_exon_variant 1473276 1 0 0 0 0 6 3546 20766 0 0 0.0010397522169524 0.999711149624494 0.999371401166804 0.999893989862555 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1417 1879 False False 0 0 4.9758630843129 0 0 0.0010397522169524 0.999711149624494 0.999371401166804 0.999893989862555 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 1607 6348 0 0 0.0022928741555424 0.999212970250275 0.99816429885228 0.999744405769873 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 754 992 False False 0 0 0 0 0 0 0 0 0 4.31499754664604 0 0 0.0022928741555424 0.999212970250275 0.99816429885228 0.999744405769873 34 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1432G>A rrs_n.1432G>A 1 non_coding_transcript_exon_variant 1473277 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 36 3) Uncertain significance No change no 1 +Kanamycin rrs n.1435_1436dupGC rrs_n.1435_1436dupGC 1 non_coding_transcript_exon_variant 1473279 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1436C>A rrs_n.1436C>A 1 non_coding_transcript_exon_variant 1473281 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1052 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1436C>T rrs_n.1436C>T 1 non_coding_transcript_exon_variant 1473281 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance No change no 1 +Kanamycin rrs n.1437C>G rrs_n.1437C>G 1 non_coding_transcript_exon_variant 1473282 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1122 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1438T>C rrs_n.1438T>C 1 non_coding_transcript_exon_variant 1473283 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1031 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 398 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 3 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1443_1446delCTCGinsTTTTA rrs_n.1443_1446delCTCGinsTTTTA 1 non_coding_transcript_exon_variant 1473288 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1395 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1443C>G rrs_n.1443C>G 1 non_coding_transcript_exon_variant 1473288 1 33 1 32 1 35 3545 20737 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.998315039476218 0.997657399390305 0.998826091293338 0.0277777777777777 0.00070302520590478 0.145289264746853 0.0303030303030303 0.000766912075048109 0.157593972272496 0.0277777777777777 0.00070302520590478 0.145289264746853 0.182801480959097 0.00449190954910706 1.09507843590239 0.0787027656769039 40 1879 False False 0.167132782591174 0.00411779324159152 0.995079664608985 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.998315039476218 0.997657399390305 0.998826091293338 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 24 1 23 1 26 1606 6327 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.995907445301432 0.994009169707483 0.99732491829892 0.037037037037037 0.000937257091944708 0.189705617413044 0.0416666666666666 0.00105435244546974 0.211201683456973 0.037037037037037 0.000937257091944708 0.189705617413044 0.171287021495478 0.00415925376570635 1.05658799117736 0.0693795259351118 26 992 False False 0 0 0 0 0 0 0 0.151523134399846 0.00369735810583067 0.923923412276214 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.995907445301432 0.994009169707483 0.99732491829892 56 3) Uncertain significance No change no 1 +Kanamycin rrs n.1443C>T rrs_n.1443C>T 1 non_coding_transcript_exon_variant 1473288 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1418 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 755 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1444_1445delTCinsCTCGT rrs_n.1444_1445delTCinsCTCGT 1 non_coding_transcript_exon_variant 1473289 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1168 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 522 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1444_1445delTCinsCTTGT rrs_n.1444_1445delTCinsCTTGT 1 non_coding_transcript_exon_variant 1473289 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1419 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 756 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1445_1446delCGinsTGT rrs_n.1445_1446delCGinsTGT 1 non_coding_transcript_exon_variant 1473290 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1368 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 708 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 2 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1445C>A rrs_n.1445C>A 1 non_coding_transcript_exon_variant 1473290 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1445C>T rrs_n.1445C>T 1 non_coding_transcript_exon_variant 1473290 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1181 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 533 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 8 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1446G>T rrs_n.1446G>T 1 non_coding_transcript_exon_variant 1473291 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1138 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 498 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1449A>G rrs_n.1449A>G 1 non_coding_transcript_exon_variant 1473294 1 5 0 5 0 5 3546 20767 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 6.39361750002021 1 617 1879 False False 0 0 6.39361750002021 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 3) Uncertain significance No change no 1 +Kanamycin rrs n.1451G>C rrs_n.1451G>C 1 non_coding_transcript_exon_variant 1473296 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1241 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1452G>T rrs_n.1452G>T 1 non_coding_transcript_exon_variant 1473297 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1357 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1454G>C rrs_n.1454G>C 1 non_coding_transcript_exon_variant 1473299 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1456T>C rrs_n.1456T>C 1 non_coding_transcript_exon_variant 1473301 1 0 0 0 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1206 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 556 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 26 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1460G>A rrs_n.1460G>A 1 non_coding_transcript_exon_variant 1473305 1 2 1 1 1 1 3545 20771 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999951858270749 0.999731800967312 0.999998781157685 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 5.8592383638928 0.0746220616644107 458.169367733398 0.270378083801644 96 1879 False False 5.8592383638928 0.0746220616644107 458.169367733398 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.101367337197729 Inf 0.201884422110552 36.5 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 3 3) Uncertain significance No change no 1 +Kanamycin rrs n.1465T>G rrs_n.1465T>G 1 non_coding_transcript_exon_variant 1473310 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Kanamycin rrs n.1468G>A rrs_n.1468G>A 1 non_coding_transcript_exon_variant 1473313 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1470T>C rrs_n.1470T>C 1 non_coding_transcript_exon_variant 1473315 1 0 0 0 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1300 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 643 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 16 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1471C>A rrs_n.1471C>A 1 non_coding_transcript_exon_variant 1473316 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1288 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1471C>T rrs_n.1471C>T 1 non_coding_transcript_exon_variant 1473316 1 0 0 0 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1420 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1607 6349 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 757 992 False False 0 0 0 0 0 0 0 0 0 5.99028746746614 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 63 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1472G>A rrs_n.1472G>A 1 non_coding_transcript_exon_variant 1473317 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1406 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1473G>A rrs_n.1473G>A 1 non_coding_transcript_exon_variant 1473318 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1032 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1474C>T rrs_n.1474C>T 1 non_coding_transcript_exon_variant 1473319 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1169 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 13 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1479G>A rrs_n.1479G>A 1 non_coding_transcript_exon_variant 1473324 1 1 1 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.150201697158088 Inf 0.14581791265729 60 1879 False False Inf 0.150201697158088 Inf 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 3) Uncertain significance No change no 1 +Kanamycin rrs n.-147G>T rrs_n.-147G>T 1 upstream_gene_variant 1471699 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1482A>G rrs_n.1482A>G 1 non_coding_transcript_exon_variant 1473327 1 1 0 1 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 227.636869136849 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Kanamycin rrs n.1483C>T rrs_n.1483C>T 1 non_coding_transcript_exon_variant 1473328 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1139 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1484G>A rrs_n.1484G>A 1 non_coding_transcript_exon_variant 1473329 1 2 1 1 1 1 3545 20771 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999951858270749 0.999731800967312 0.999998781157685 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 5.8592383638928 0.0746220616644107 458.169367733398 0.270378083801644 96 1879 False False 5.8592383638928 0.0746220616644107 458.169367733398 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.1484G>T rrs_n.1484G>T 1 non_coding_transcript_exon_variant 1473329 1 16 15 1 23 1 3523 20771 0.00648618161308516 0.00411599488822813 0.00971665290667189 0.999951858270749 0.999731800967312 0.999998781157685 0.958333333333333 0.788798316543026 0.99894564755453 0.9375 0.697679261565468 0.998418888277234 0.9375 0.697679261565468 0.998418888277234 88.4374112971899 13.5938661426335 3643.7795159576 3.75165990991915e-12 9 1879 True False 135.604030655691 22.0003472542808 5398.21175473682 0.00423968343697003 0.00237480120839825 0.00698308682490678 0.999951858270749 0.999731800967312 0.999998781157685 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 8 7 1 10 1 1597 6352 0.00622277535780958 0.00298797623318756 0.0114140395320774 0.999842594050055 0.999123305664052 0.999996014834324 0.909090909090909 0.587220083011617 0.997701027786185 0.875 0.473490329124793 0.996840276468748 0.875 0.473490329124793 0.996840276468748 27.8422041327489 3.57091112363166 1246.58894759312 8.82624774772034e-05 9 992 True False 0 0 0 0 0 0 0 39.7745773324984 5.64794153985064 1710.66467362882 0.00436408977556109 0.00175633592121866 0.00897089928676497 0.999842594050055 0.999123305664052 0.999996014834324 25 Assoc w R Marker of R 1) Assoc w R No change yes 1 +Kanamycin rrs n.1489C>T rrs_n.1489C>T 1 non_coding_transcript_exon_variant 1473334 0 0 0 0 2 0 3544 20772 0.000564015792442188 6.83122290578968e-05 0.00203591855262226 1 0.99982242673208 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1123 1879 False False Inf 1.10031452590981 Inf 0 0 0.0010403386792448 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Kanamycin rrs n.1491T>A rrs_n.1491T>A 1 non_coding_transcript_exon_variant 1473336 1 2 0 2 0 5 3546 20767 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 0 0 0.521823750104981 0 0 0.841886116991581 0 0 0.521823750104981 0 0 31.2131924627285 1 617 1879 False False 0 0 6.39361750002021 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 21.0547398420152 1 233 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 3 3) Uncertain significance No change no 1 +Kanamycin rrs n.1491T>C rrs_n.1491T>C 1 non_coding_transcript_exon_variant 1473336 0 0 0 0 2 1 3544 20771 0.000564015792442188 6.83122290578968e-05 0.00203591855262226 0.999951858270749 0.999731800967312 0.999998781157685 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 1358 1879 False False 11.721783295711 0.609968155150262 688.286392190459 0 0 0.0010403386792448 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1500A>T rrs_n.1500A>T 1 non_coding_transcript_exon_variant 1473345 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.1503C>T rrs_n.1503C>T 1 non_coding_transcript_exon_variant 1473348 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.1507C>T rrs_n.1507C>T 1 non_coding_transcript_exon_variant 1473352 0 0 0 0 3 12 3543 20760 0.000846023688663282 0.000174504417422474 0.00247043033885164 0.999422299248989 0.998991090727643 0.999701459098715 0.2 0.0433120051058366 0.480891133806853 NA NA NA 0 0 0.264648469397051 NA NA NA NA 1016 1879 False False 1.46486028789161 0.265136396552824 5.43152239296991 0 0 0.00104063215855229 0.999422299248989 0.998991090727643 0.999701459098715 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 7 1606 6346 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.998898158350385 0.997731111129242 0.999556891392146 0.125 0.0031597235312519 0.526509670875206 NA NA NA 0 0 0.409616397225003 NA NA NA NA 383 992 False False 0 0 0 0 0 0 0 0.564490304216331 0.0125208374793046 4.39917903285694 0 0 0.00229430020901157 0.998898158350385 0.997731111129242 0.999556891392146 136 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1515T>C rrs_n.1515T>C 1 non_coding_transcript_exon_variant 1473360 0 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1101 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 462 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.1519G>A rrs_n.1519G>A 1 non_coding_transcript_exon_variant 1473364 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.1523G>A rrs_n.1523G>A 1 non_coding_transcript_exon_variant 1473368 1 4 1 3 1 3 3545 20769 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999855574812247 0.999577986903419 0.999970215063798 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 1.95289139633286 0.0371893922070044 24.3461286113284 0.467666809374076 123.5 1879 False False 1.95289139633286 0.0371893922070044 24.3461286113284 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.160dupT rrs_n.160dupT 1 non_coding_transcript_exon_variant 1472004 1 4 2 2 2 2 3544 20770 0.000564015792442188 6.83122290578968e-05 0.00203591855262226 0.999903716541498 0.99965223478104 0.999988339413789 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 5.86060948081264 0.424646188620106 80.7055921553874 0.104114689587947 43 1879 False False 5.86060948081264 0.424646188620106 80.7055921553874 0.000564015792442188 6.83122290578968e-05 0.00203591855262226 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 1605 6353 0.00124455507156191 0.000150756945780856 0.00448845844972244 1 0.999419516970794 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.742689158362403 Inf 0.0407370752493464 22 992 False False 0 0 0 0 0 0 0 Inf 0.742689158362403 Inf 0.00124455507156191 0.000150756945780856 0.00448845844972244 1 0.999419516970794 1 1 3) Uncertain significance No change no 1 +Kanamycin rrs n.165C>A rrs_n.165C>A 1 non_coding_transcript_exon_variant 1472010 0 0 0 0 1 1 3545 20771 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999951858270749 0.999731800967312 0.999998781157685 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1072 1879 False False 5.8592383638928 0.0746220616644107 458.169367733398 0 0 0.00104004536542481 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 1606 6352 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.999842594050055 0.999123305664052 0.999996014834324 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 435 992 False False 0 0 0 0 0 0 0 3.95516811955168 0.0503551805307198 309.72516523151 0 0 0.00229430020901157 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.166T>G rrs_n.166T>G 1 non_coding_transcript_exon_variant 1472011 0 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1053 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.169T>C rrs_n.169T>C 1 non_coding_transcript_exon_variant 1472014 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.16T>A rrs_n.16T>A 1 non_coding_transcript_exon_variant 1471861 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance No change no 1 +Kanamycin rrs n.16T>C rrs_n.16T>C 1 non_coding_transcript_exon_variant 1471861 1 2 0 2 1 3 3545 20769 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999855574812247 0.999577986903419 0.999970215063798 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 31.2251999123303 1 617 1879 False False 1.95289139633286 0.0371893922070044 24.3461286113284 0 0 0.00104004536542481 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 2 3) Uncertain significance No change no 1 +Kanamycin rrs n.16T>G rrs_n.16T>G 1 non_coding_transcript_exon_variant 1471861 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1216 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.170A>G rrs_n.170A>G 1 non_coding_transcript_exon_variant 1472015 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Kanamycin rrs n.178G>A rrs_n.178G>A 1 non_coding_transcript_exon_variant 1472023 1 1 1 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.150201697158088 Inf 0.14581791265729 60 1879 False False Inf 0.150201697158088 Inf 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.101367337197729 Inf 0.201884422110552 36.5 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.179G>T rrs_n.179G>T 1 non_coding_transcript_exon_variant 1472024 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.17T>G rrs_n.17T>G 1 non_coding_transcript_exon_variant 1471862 1 7 0 7 2 8 3544 20764 0.000564015792442188 6.83122290578968e-05 0.00203591855262226 0.999614866165992 0.999241274614236 0.99983371235125 0.2 0.0252107263268333 0.556095462307641 0 0 0.409616397225003 0 0 0.369416647552819 0 0 4.06690522104782 0.603468465815011 139 1879 False False 1.46472911963882 0.151439261401278 7.34364495908934 0 0 0.0010403386792448 0.999614866165992 0.999241274614236 0.99983371235125 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 153.787547206498 1 233 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 11 3) Uncertain significance No change no 1 +Kanamycin rrs n.180A>C rrs_n.180A>C 1 non_coding_transcript_exon_variant 1472025 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.181C>T rrs_n.181C>T 1 non_coding_transcript_exon_variant 1472026 0 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1289 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.182_200dupCACGGGATGCATGTCTTGT rrs_n.182_200dupCACGGGATGCATGTCTTGT 1 non_coding_transcript_exon_variant 1472026 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.182C>G rrs_n.182C>G 1 non_coding_transcript_exon_variant 1472027 1 2 0 2 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 31.2162477992404 1 193 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.184C>T rrs_n.184C>T 1 non_coding_transcript_exon_variant 1472029 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1182 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 534 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.185G>A rrs_n.185G>A 1 non_coding_transcript_exon_variant 1472030 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1054 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 417 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.186G>C rrs_n.186G>C 1 non_coding_transcript_exon_variant 1472031 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1341 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 682 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.187G>A rrs_n.187G>A 1 non_coding_transcript_exon_variant 1472032 1 2 0 2 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 31.2162477992404 1 193 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 21.0547398420152 1 233 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.188A>C rrs_n.188A>C 1 non_coding_transcript_exon_variant 1472033 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1017 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 384 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.190G>T rrs_n.190G>T 1 non_coding_transcript_exon_variant 1472035 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1195 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 548 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.195T>G rrs_n.195T>G 1 non_coding_transcript_exon_variant 1472040 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1381 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 720 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.196C>T rrs_n.196C>T 1 non_coding_transcript_exon_variant 1472041 1 2 0 2 0 5 3546 20767 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 0 0 0.521823750104981 0 0 0.841886116991581 0 0 0.521823750104981 0 0 31.2131924627285 1 617 1879 False False 0 0 6.39361750002021 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 4 1607 6349 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 153.739241752309 1 233 992 False False 0 0 0 0 0 0 0 0 0 5.99028746746614 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 1 3) Uncertain significance No change no 1 +Kanamycin rrs n.197T>C rrs_n.197T>C 1 non_coding_transcript_exon_variant 1472042 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1421 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 758 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.197T>G rrs_n.197T>G 1 non_coding_transcript_exon_variant 1472042 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1301 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 644 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.198T>A rrs_n.198T>A 1 non_coding_transcript_exon_variant 1472043 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1124 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 484 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.-2_-1insGTTTTGTTTGGAGA rrs_n.-2_-1insGTTTTGTTTGGAGA 1 upstream_gene_variant 1471844 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1026 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Kanamycin rrs n.-20_-19insTCCAAAGGGA rrs_n.-20_-19insTCCAAAGGGA 1 upstream_gene_variant 1471826 1 4 0 4 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 8.87534793394977 1 617 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.200T>A rrs_n.200T>A 1 non_coding_transcript_exon_variant 1472045 1 5 0 5 0 7 3546 20765 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 0 0 0.409616397225003 0 0 0.521823750104981 0 0 0.409616397225003 0 0 6.39300177623657 1 193 1879 False False 0 0 4.06480602430196 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 5 1607 6348 0 0 0.0022928741555424 0.999212970250275 0.99816429885228 0.999744405769873 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 9.56783849543449 1 233 992 False False 0 0 0 0 0 0 0 0 0 4.31499754664604 0 0 0.0022928741555424 0.999212970250275 0.99816429885228 0.999744405769873 7 3) Uncertain significance No change no 1 +Kanamycin rrs n.205G>C rrs_n.205G>C 1 non_coding_transcript_exon_variant 1472050 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1073 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 436 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.211_212delGC rrs_n.211_212delGC 1 non_coding_transcript_exon_variant 1472053 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1045 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 411 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.212C>T rrs_n.212C>T 1 non_coding_transcript_exon_variant 1472057 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Kanamycin rrs n.213T>A rrs_n.213T>A 1 non_coding_transcript_exon_variant 1472058 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.213T>C rrs_n.213T>C 1 non_coding_transcript_exon_variant 1472058 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.213T>G rrs_n.213T>G 1 non_coding_transcript_exon_variant 1472058 1 5 0 5 0 5 3546 20767 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 6.39361750002021 1 617 1879 False False 0 0 6.39361750002021 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Kanamycin rrs n.216A>T rrs_n.216A>T 1 non_coding_transcript_exon_variant 1472061 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1217 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 566 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.225G>C rrs_n.225G>C 1 non_coding_transcript_exon_variant 1472070 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.230A>G rrs_n.230A>G 1 non_coding_transcript_exon_variant 1472075 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1018 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 385 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 3 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.236C>G rrs_n.236C>G 1 non_coding_transcript_exon_variant 1472081 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.239C>A rrs_n.239C>A 1 non_coding_transcript_exon_variant 1472084 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.23T>C rrs_n.23T>C 1 non_coding_transcript_exon_variant 1471868 0 0 0 0 2 0 3544 20772 0.000564015792442188 6.83122290578968e-05 0.00203591855262226 1 0.99982242673208 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1242 1879 False False Inf 1.10031452590981 Inf 0 0 0.0010403386792448 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Kanamycin rrs n.23T>G rrs_n.23T>G 1 non_coding_transcript_exon_variant 1471868 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Kanamycin rrs n.246_247dupGC rrs_n.246_247dupGC 1 non_coding_transcript_exon_variant 1472090 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1033 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.247C>T rrs_n.247C>T 1 non_coding_transcript_exon_variant 1472092 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Kanamycin rrs n.24G>A rrs_n.24G>A 1 non_coding_transcript_exon_variant 1471869 1 2 0 2 0 5 3546 20767 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 0 0 0.521823750104981 0 0 0.841886116991581 0 0 0.521823750104981 0 0 31.2131924627285 1 617 1879 False False 0 0 6.39361750002021 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 577 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.257G>A rrs_n.257G>A 1 non_coding_transcript_exon_variant 1472102 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1102 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 463 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 13 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.259dupG rrs_n.259dupG 1 non_coding_transcript_exon_variant 1472100 1 2 0 2 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 31.2162477992404 1 193 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.259G>A rrs_n.259G>A 1 non_coding_transcript_exon_variant 1472104 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.-25C>A rrs_n.-25C>A 1 upstream_gene_variant 1471821 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.261G>A rrs_n.261G>A 1 non_coding_transcript_exon_variant 1472106 1 0 0 0 0 7 3546 20765 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1074 1879 False False 0 0 4.06480602430196 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 1607 6347 0 0 0.0022928741555424 0.99905556430033 0.997945503023207 0.999653332387469 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 437 992 False False 0 0 0 0 0 0 0 0 0 3.35786664322939 0 0 0.0022928741555424 0.99905556430033 0.997945503023207 0.999653332387469 75 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.262A>G rrs_n.262A>G 1 non_coding_transcript_exon_variant 1472107 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1055 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 418 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 8 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.263C>T rrs_n.263C>T 1 non_coding_transcript_exon_variant 1472108 1 1 0 1 0 6 3546 20766 0 0 0.0010397522169524 0.999711149624494 0.999371401166804 0.999893989862555 0 0 0.4592581264399 0 0 0.975 0 0 0.4592581264399 0 0 227.593187588584 1 193 1879 False False 0 0 4.9758630843129 0 0 0.0010397522169524 0.999711149624494 0.999371401166804 0.999893989862555 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 1607 6348 0 0 0.0022928741555424 0.999212970250275 0.99816429885228 0.999744405769873 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 450 992 False False 0 0 0 0 0 0 0 0 0 4.31499754664604 0 0 0.0022928741555424 0.999212970250275 0.99816429885228 0.999744405769873 73 3) Uncertain significance No change no 1 +Kanamycin rrs n.266C>T rrs_n.266C>T 1 non_coding_transcript_exon_variant 1472111 0 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1278 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Kanamycin rrs n.267C>T rrs_n.267C>T 1 non_coding_transcript_exon_variant 1472112 1 0 0 0 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1302 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 645 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 37 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.268T>C rrs_n.268T>C 1 non_coding_transcript_exon_variant 1472113 1 3 0 3 0 8 3546 20764 0 0 0.0010397522169524 0.999614866165992 0.999241274614236 0.99983371235125 0 0 0.369416647552819 0 0 0.707598226178713 0 0 0.369416647552819 0 0 14.1748758749384 1 617 1879 False False 0 0 3.43205141622579 0 0 0.0010397522169524 0.999614866165992 0.999241274614236 0.99983371235125 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 7 1607 6346 0 0 0.0022928741555424 0.998898158350385 0.997731111129242 0.999556891392146 0 0 0.409616397225003 0 0 0.707598226178713 0 0 0.409616397225003 0 0 9.56482572431895 1 233 992 False False 0 0 0 0 0 0 0 0 0 2.74289259224573 0 0 0.0022928741555424 0.998898158350385 0.997731111129242 0.999556891392146 22 3) Uncertain significance No change no 1 +Kanamycin rrs n.273A>T rrs_n.273A>T 1 non_coding_transcript_exon_variant 1472118 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.277G>A rrs_n.277G>A 1 non_coding_transcript_exon_variant 1472122 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1019 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 386 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 15 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.278A>G rrs_n.278A>G 1 non_coding_transcript_exon_variant 1472123 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1155 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 511 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 3 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.279C>A rrs_n.279C>A 1 non_coding_transcript_exon_variant 1472124 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.279C>T rrs_n.279C>T 1 non_coding_transcript_exon_variant 1472124 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1156 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 512 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 38 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.-27C>A rrs_n.-27C>A 1 upstream_gene_variant 1471819 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1148 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Kanamycin rrs n.282C>T rrs_n.282C>T 1 non_coding_transcript_exon_variant 1472127 2 1 0 1 1 8 3545 20764 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999614866165992 0.999241274614236 0.99983371235125 0.111111111111111 0.00280913674659921 0.482496514917337 0 0 0.975 0 0 0.369416647552819 0 0 227.635313483301 1 617 1879 False False 0.73215796897038 0.0164955563131374 5.46332200200716 0 0 0.00104004536542481 0.999614866165992 0.999241274614236 0.99983371235125 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 1607 6348 0 0 0.0022928741555424 0.999212970250275 0.99816429885228 0.999744405769873 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 451 992 False False 0 0 0 0 0 0 0 0 0 4.31499754664604 0 0 0.0022928741555424 0.999212970250275 0.99816429885228 0.999744405769873 56 3) Uncertain significance No change no 1 +Kanamycin rrs n.284G>C rrs_n.284G>C 1 non_coding_transcript_exon_variant 1472129 0 0 0 0 1 7 3545 20765 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999663007895243 0.999305791518941 0.999864501305137 0.125 0.0031597235312519 0.526509670875206 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1218 1879 False False 0.836792262744307 0.0185616714978769 6.51673926470685 0 0 0.00104004536542481 0.999663007895243 0.999305791518941 0.999864501305137 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 1607 6348 0 0 0.0022928741555424 0.999212970250275 0.99816429885228 0.999744405769873 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 567 992 False False 0 0 0 0 0 0 0 0 0 4.31499754664604 0 0 0.0022928741555424 0.999212970250275 0.99816429885228 0.999744405769873 52 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.287A>G rrs_n.287A>G 1 non_coding_transcript_exon_variant 1472132 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.-28G>A rrs_n.-28G>A 1 upstream_gene_variant 1471818 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1400 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 738 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.292G>A rrs_n.292G>A 1 non_coding_transcript_exon_variant 1472137 0 0 0 0 3 9 3543 20763 0.000846023688663282 0.000174504417422474 0.00247043033885164 0.999566724436741 0.999177668076772 0.99980186029375 0.25 0.0548606445279927 0.571858461878189 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1263 1879 False False 1.95342929720575 0.339990897951816 7.83201601856074 0 0 0.00104063215855229 0.999566724436741 0.999177668076772 0.99980186029375 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 7 1606 6346 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.998898158350385 0.997731111129242 0.999556891392146 0.125 0.0031597235312519 0.526509670875206 NA NA NA 0 0 0.409616397225003 NA NA NA NA 608 992 False False 0 0 0 0 0 0 0 0.564490304216331 0.0125208374793046 4.39917903285694 0 0 0.00229430020901157 0.998898158350385 0.997731111129242 0.999556891392146 105 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.297A>C rrs_n.297A>C 1 non_coding_transcript_exon_variant 1472142 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.298_299insT rrs_n.298_299insT 1 non_coding_transcript_exon_variant 1472143 1 3 0 3 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 14.1782880202046 1 617 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.0580478247511 1 233 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.299A>G rrs_n.299A>G 1 non_coding_transcript_exon_variant 1472144 0 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1279 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 625 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.300_301insT rrs_n.300_301insT 1 non_coding_transcript_exon_variant 1472145 1 1 1 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.150201697158088 Inf 0.14581791265729 60 1879 False False Inf 0.150201697158088 Inf 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.101367337197729 Inf 0.201884422110552 36.5 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.303T>C rrs_n.303T>C 1 non_coding_transcript_exon_variant 1472148 1 0 0 0 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1326 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1607 6349 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 669 992 False False 0 0 0 0 0 0 0 0 0 5.99028746746614 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 10 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.304_305dupGT rrs_n.304_305dupGT 1 non_coding_transcript_exon_variant 1472146 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1382 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 721 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.305T>A rrs_n.305T>A 1 non_coding_transcript_exon_variant 1472150 0 0 0 0 3 19 3543 20753 0.000846023688663282 0.000174504417422474 0.00247043033885164 0.999085307144232 0.998571960712224 0.999449208150065 0.136363636363636 0.0290558511287467 0.349122097257408 NA NA NA 0 0 0.176466911806965 NA NA NA NA 1422 1879 False False 0.924862961807567 0.175189543374916 3.14449204349987 0 0 0.00104063215855229 0.999085307144232 0.998571960712224 0.999449208150065 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 17 1606 6336 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.997324098850936 0.995719069008731 0.998440440224704 0.0555555555555555 0.00140555616736942 0.272943599673368 NA NA NA 0 0 0.195064322969093 NA NA NA NA 759 992 False False 0 0 0 0 0 0 0 0.232070910556003 0.00555318201394532 1.48344099579824 0 0 0.00229430020901157 0.997324098850936 0.995719069008731 0.998440440224704 235 3) Uncertain significance No change no 1 +Kanamycin rrs n.306C>A rrs_n.306C>A 1 non_coding_transcript_exon_variant 1472151 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1369 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 15 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.306C>T rrs_n.306C>T 1 non_coding_transcript_exon_variant 1472151 1 1 0 1 3 10 3543 20762 0.000846023688663282 0.000174504417422474 0.00247043033885164 0.99951858270749 0.999114835261082 0.999769118326375 0.23076923076923 0.0503810734911515 0.53813153923404 0 0 0.975 0 0 0.30849710781876 0 0 227.741495633288 1 617 1879 False False 1.7580016934801 0.310751426112262 6.8304991387246 0 0 0.00104063215855229 0.99951858270749 0.999114835261082 0.999769118326375 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 8 1606 6345 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.99874075240044 0.997520296036287 0.99945619445686 0.111111111111111 0.00280913674659921 0.482496514917337 NA NA NA 0 0 0.369416647552819 NA NA NA NA 589 992 False False 0 0 0 0 0 0 0 0.493851183063511 0.0111262820523154 3.6883573216039 0 0 0.00229430020901157 0.99874075240044 0.997520296036287 0.99945619445686 95 3) Uncertain significance No change no 1 +Kanamycin rrs n.315C>T rrs_n.315C>T 1 non_coding_transcript_exon_variant 1472160 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1316 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 660 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 59 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.319G>A rrs_n.319G>A 1 non_coding_transcript_exon_variant 1472164 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1115 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 477 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 31 3) Uncertain significance No change no 1 +Kanamycin rrs n.327T>C rrs_n.327T>C 1 non_coding_transcript_exon_variant 1472172 0 0 0 0 4 33 3542 20739 0.00112803158488437 0.000307433460438748 0.00288566784728404 0.998411322934719 0.997769623498813 0.998906183277335 0.108108108108108 0.0302519650687496 0.254175936077478 NA NA NA 0 0 0.105762810074579 NA NA NA NA 1046 1879 False False 0.709717160310045 0.182555619756157 1.9971185253669 0 0 0.00104092580348739 0.998411322934719 0.997769623498813 0.998906183277335 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 27 1606 6326 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.995750039351487 0.993822510446037 0.997197437356178 0.0357142857142857 0.000903798755658059 0.183477597544623 NA NA NA 0 0 0.127702867615432 NA NA NA NA 412 992 False False 0 0 0 0 0 0 0 0.145888104792214 0.00356483617429647 0.88663005021408 0 0 0.00229430020901157 0.995750039351487 0.993822510446037 0.997197437356178 241 3) Uncertain significance No change no 1 +Kanamycin rrs n.32A>G rrs_n.32A>G 1 non_coding_transcript_exon_variant 1471877 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance No change no 1 +Kanamycin rrs n.-32T>G rrs_n.-32T>G 1 upstream_gene_variant 1471814 0 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1093 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 456 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 4 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.332C>T rrs_n.332C>T 1 non_coding_transcript_exon_variant 1472177 1 0 0 0 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1140 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 499 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 39 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.333C>T rrs_n.333C>T 1 non_coding_transcript_exon_variant 1472178 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Kanamycin rrs n.335A>C rrs_n.335A>C 1 non_coding_transcript_exon_variant 1472180 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.336G>A rrs_n.336G>A 1 non_coding_transcript_exon_variant 1472181 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1264 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 609 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 5 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.33C>T rrs_n.33C>T 1 non_coding_transcript_exon_variant 1471878 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1125 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 485 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 40 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.340C>T rrs_n.340C>T 1 non_coding_transcript_exon_variant 1472185 1 1 1 0 2 2 3544 20770 0.000564015792442188 6.83122290578968e-05 0.00203591855262226 0.999903716541498 0.99965223478104 0.999988339413789 0.5 0.067585986488543 0.932414013511457 1 0.025 1 0.333333333333333 0.00840375865961264 0.905700675949754 Inf 0.15022960117351 Inf 0.145794776886695 48 1879 False False 5.86060948081264 0.424646188620106 80.7055921553874 0.000282087447108603 7.14181031782542e-06 0.001570677606179 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Kanamycin rrs n.344C>T rrs_n.344C>T 1 non_coding_transcript_exon_variant 1472189 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.349G>A rrs_n.349G>A 1 non_coding_transcript_exon_variant 1472194 1 3 0 3 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 14.1782880202046 1 617 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.57085126512166 1 233 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 7 3) Uncertain significance No change no 1 +Kanamycin rrs n.-34C>A rrs_n.-34C>A 1 upstream_gene_variant 1471812 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.358G>A rrs_n.358G>A 1 non_coding_transcript_exon_variant 1472203 2 1 0 1 3 11 3543 20761 0.000846023688663282 0.000174504417422474 0.00247043033885164 0.99947044097824 0.999052670645628 0.99973561734751 0.214285714285714 0.0465792878898673 0.507975677048471 0 0 0.975 0 0 0.284914152918154 0 0 227.730566040969 1 193 1879 False False 1.59810638134092 0.286129216218252 6.05369020552991 0 0 0.00104063215855229 0.99947044097824 0.999052670645628 0.99973561734751 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 8 1606 6345 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.99874075240044 0.997520296036287 0.99945619445686 0.111111111111111 0.00280913674659921 0.482496514917337 NA NA NA 0 0 0.369416647552819 NA NA NA NA 387 992 False False 0 0 0 0 0 0 0 0.493851183063511 0.0111262820523154 3.6883573216039 0 0 0.00229430020901157 0.99874075240044 0.997520296036287 0.99945619445686 129 3) Uncertain significance No change no 1 +Kanamycin rrs n.358G>T rrs_n.358G>T 1 non_coding_transcript_exon_variant 1472203 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1196 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.365A>C rrs_n.365A>C 1 non_coding_transcript_exon_variant 1472210 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1229 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 578 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 38 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.365A>G rrs_n.365A>G 1 non_coding_transcript_exon_variant 1472210 1 1 1 0 4 0 3542 20772 0.00112803158488437 0.000307433460438748 0.00288566784728404 1 0.99982242673208 1 1 0.397635364383525 1 1 0.025 1 1 0.025 1 Inf 0.15032887904429 Inf 0.145712523133868 45.5 1879 False False Inf 3.86904162096631 Inf 0.000282246683601467 7.14584180797538e-06 0.00157156367129611 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 464 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.368G>C rrs_n.368G>C 1 non_coding_transcript_exon_variant 1472213 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1359 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 698 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 58 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.370A>G rrs_n.370A>G 1 non_coding_transcript_exon_variant 1472215 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1020 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 388 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 41 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.378C>G rrs_n.378C>G 1 non_coding_transcript_exon_variant 1472223 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1360 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 699 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 3 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.37C>T rrs_n.37C>T 1 non_coding_transcript_exon_variant 1471882 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.380C>A rrs_n.380C>A 1 non_coding_transcript_exon_variant 1472225 1 0 0 0 0 6 3546 20766 0 0 0.0010397522169524 0.999711149624494 0.999371401166804 0.999893989862555 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1157 1879 False False 0 0 4.9758630843129 0 0 0.0010397522169524 0.999711149624494 0.999371401166804 0.999893989862555 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 1607 6347 0 0 0.0022928741555424 0.99905556430033 0.997945503023207 0.999653332387469 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 513 992 False False 0 0 0 0 0 0 0 0 0 3.35786664322939 0 0 0.0022928741555424 0.99905556430033 0.997945503023207 0.999653332387469 116 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.383G>C rrs_n.383G>C 1 non_coding_transcript_exon_variant 1472228 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1342 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 683 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 3 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.389T>C rrs_n.389T>C 1 non_coding_transcript_exon_variant 1472234 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1158 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 514 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 33 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.38G>A rrs_n.38G>A 1 non_coding_transcript_exon_variant 1471883 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.395G>A rrs_n.395G>A 1 non_coding_transcript_exon_variant 1472240 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1303 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 646 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 61 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.-40_-39insA rrs_n.-40_-39insA 1 upstream_gene_variant 1471806 1 2 0 2 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 31.21472012401 1 617 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 690 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance No change no 1 +Kanamycin rrs n.401G>A rrs_n.401G>A 1 non_coding_transcript_exon_variant 1472246 0 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1056 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 419 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.406G>A rrs_n.406G>A 1 non_coding_transcript_exon_variant 1472251 1 1 0 1 0 16 3546 20756 0 0 0.0010397522169524 0.999229732331985 0.998749434152838 0.999559663409708 0 0 0.205907214207822 0 0 0.975 0 0 0.205907214207822 0 0 227.483983456121 1 617 1879 False False 0 0 1.51862445866705 0 0 0.0010397522169524 0.999229732331985 0.998749434152838 0.999559663409708 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 16 1607 6337 0 0 0.0022928741555424 0.997481504800881 0.995913335169992 0.998559798442438 0 0 0.205907214207822 0 0 0.975 0 0 0.205907214207822 0 0 153.449407492173 1 233 992 False False 0 0 0 0 0 0 0 0 0 1.02392256349426 0 0 0.0022928741555424 0.997481504800881 0.995913335169992 0.998559798442438 140 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.408G>A rrs_n.408G>A 1 non_coding_transcript_exon_variant 1472253 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.414C>A rrs_n.414C>A 1 non_coding_transcript_exon_variant 1472259 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1407 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 742 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 49 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.414C>T rrs_n.414C>T 1 non_coding_transcript_exon_variant 1472259 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.415G>A rrs_n.415G>A 1 non_coding_transcript_exon_variant 1472260 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Kanamycin rrs n.424G>A rrs_n.424G>A 1 non_coding_transcript_exon_variant 1472269 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Kanamycin rrs n.433C>T rrs_n.433C>T 1 non_coding_transcript_exon_variant 1472278 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1304 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 647 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.434T>C rrs_n.434T>C 1 non_coding_transcript_exon_variant 1472279 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1183 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 535 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.43C>G rrs_n.43C>G 1 non_coding_transcript_exon_variant 1471888 0 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1383 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 722 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.440A>G rrs_n.440A>G 1 non_coding_transcript_exon_variant 1472285 1 1 0 1 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 227.636869136849 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 536 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.441C>T rrs_n.441C>T 1 non_coding_transcript_exon_variant 1472286 1 1 0 1 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 227.636869136849 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Kanamycin rrs n.444T>G rrs_n.444T>G 1 non_coding_transcript_exon_variant 1472289 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1280 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 626 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 2 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.445C>G rrs_n.445C>G 1 non_coding_transcript_exon_variant 1472290 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1343 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 684 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 2 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.445C>T rrs_n.445C>T 1 non_coding_transcript_exon_variant 1472290 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1141 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 500 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.447A>G rrs_n.447A>G 1 non_coding_transcript_exon_variant 1472292 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Kanamycin rrs n.453_464delGTCCGGGTTCTCinsCCCT rrs_n.453_464delGTCCGGGTTCTCinsCCCT 1 non_coding_transcript_exon_variant 1472298 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1255 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 603 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.454T>C rrs_n.454T>C 1 non_coding_transcript_exon_variant 1472299 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Kanamycin rrs n.459G>A rrs_n.459G>A 1 non_coding_transcript_exon_variant 1472304 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.45G>A rrs_n.45G>A 1 non_coding_transcript_exon_variant 1471890 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.462C>T rrs_n.462C>T 1 non_coding_transcript_exon_variant 1472307 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.0580478247511 1 233 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 1 3) Uncertain significance No change no 1 +Kanamycin rrs n.469_476dupATTGACGG rrs_n.469_476dupATTGACGG 1 non_coding_transcript_exon_variant 1472310 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1408 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 743 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.469A>G rrs_n.469A>G 1 non_coding_transcript_exon_variant 1472314 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1290 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 634 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.470T>G rrs_n.470T>G 1 non_coding_transcript_exon_variant 1472315 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1116 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 478 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.474C>T rrs_n.474C>T 1 non_coding_transcript_exon_variant 1472319 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.47G>A rrs_n.47G>A 1 non_coding_transcript_exon_variant 1471892 1 3 1 2 1 2 3545 20770 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999903716541498 0.99965223478104 0.999988339413789 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 2.92947813822284 0.0496406430315194 56.2247306595764 0.376778779427543 114.5 1879 False False 2.92947813822284 0.0496406430315194 56.2247306595764 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.101367337197729 Inf 0.201884422110552 36.5 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 11 3) Uncertain significance No change no 1 +Kanamycin rrs n.492C>G rrs_n.492C>G 1 non_coding_transcript_exon_variant 1472337 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1265 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 610 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.492C>T rrs_n.492C>T 1 non_coding_transcript_exon_variant 1472337 1 727 49 678 61 718 3485 20054 0.0172024816694867 0.0131834284319519 0.0220430893895891 0.965434238397843 0.962859895998984 0.967877226703591 0.0783055198973042 0.0604242264158238 0.0994527533457202 0.0674002751031636 0.0502755614647193 0.0881306738264054 0.0638852672750977 0.0476327778332202 0.0835832351226995 0.415876724097798 0.303937765140746 0.557583007906704 5.04148937203572e-11 NA NA False True 0.488881517686223 0.3691549068725 0.637291872460233 0.0138653084323712 0.0102747639995131 0.0182896709160034 0.965434238397843 0.962859895998984 0.967877226703591 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 204 2 202 5 213 1602 6140 0.00311138767890479 0.00101100708660053 0.00724588638281331 0.966472532661734 0.961747813462233 0.970762393053979 0.0229357798165137 0.00748816830913172 0.0527099290528445 0.00980392156862745 0.00118951343500511 0.034964511124087 0.00930232558139534 0.00112854681271541 0.0331973723971734 0.0379476149862177 0.00458079363064159 0.139176759848217 1.57971525455291e-17 NA NA False True 1 1 1 0 0 1 0 0.0899696975025349 0.0288598167601712 0.213840302708751 0.00124688279301745 0.000151038976792917 0.00449683964988635 0.966472532661734 0.961747813462233 0.970762393053979 433 Not assoc w R 5) Not assoc w R No change yes 1 +Kanamycin rrs n.493A>G rrs_n.493A>G 1 non_coding_transcript_exon_variant 1472338 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1197 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 549 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 9 3) Uncertain significance No change no 1 +Kanamycin rrs n.499C>T rrs_n.499C>T 1 non_coding_transcript_exon_variant 1472344 0 0 0 0 2 16 3544 20756 0.000564015792442188 6.83122290578968e-05 0.00203591855262226 0.999229732331985 0.998749434152838 0.999559663409708 0.111111111111111 0.0137512156643644 0.347120438608672 NA NA NA 0 0 0.205907214207822 NA NA NA NA 1075 1879 False False 0.732082392776523 0.081624583787321 3.11610509661289 0 0 0.0010403386792448 0.999229732331985 0.998749434152838 0.999559663409708 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 13 1606 6340 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.997953722650716 0.996503345413809 0.998910007694291 0.0714285714285714 0.00180678065912538 0.338684489931821 NA NA NA 0 0 0.24705263800047 NA NA NA NA 438 992 False False 0 0 0 0 0 0 0 0.30366893380592 0.00714464649823022 2.02468686659141 0 0 0.00229430020901157 0.997953722650716 0.996503345413809 0.998910007694291 106 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.-4T>G rrs_n.-4T>G 1 upstream_gene_variant 1471842 1 34 0 34 0 34 3546 20738 0 0 0.0010397522169524 0.998363181205468 0.997713453833747 0.998866197296832 0 0 0.102817924259012 0 0 0.102817924259012 0 0 0.102817924259012 0 0 0.670625973355984 0.00685937523240598 26 1879 False False 0 0 0.670625973355984 0 0 0.0010397522169524 0.998363181205468 0.997713453833747 0.998866197296832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 0 9 1607 6344 0 0 0.0022928741555424 0.998583346450495 0.997312461277908 0.999352017626566 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.336267116879942 0 0 2.00246403812054 0.219283706073922 42.5 992 False False 0 0 0 0 0 0 0 0 0 2.00246403812054 0 0 0.0022928741555424 0.998583346450495 0.997312461277908 0.999352017626566 53 3) Uncertain significance No change no 1 +Kanamycin rrs n.5_6delGTinsTGG rrs_n.5_6delGTinsTGG 1 non_coding_transcript_exon_variant 1471850 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1088 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 452 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 6 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.5_6insC rrs_n.5_6insC 1 non_coding_transcript_exon_variant 1471850 1 4 0 4 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 8.87534793394977 1 617 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.500A>G rrs_n.500A>G 1 non_coding_transcript_exon_variant 1472345 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1243 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 590 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.504A>G rrs_n.504A>G 1 non_coding_transcript_exon_variant 1472349 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1142 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Kanamycin rrs n.-50A>G rrs_n.-50A>G 1 upstream_gene_variant 1471796 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1094 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.513C>T rrs_n.513C>T 1 non_coding_transcript_exon_variant 1472358 1 13 2 11 6 12 3540 20760 0.00169204737732656 0.000621196730345483 0.00367920983862615 0.999422299248989 0.998991090727643 0.999701459098715 0.333333333333333 0.133427402506123 0.590074761827925 0.153846153846153 0.0192066719825284 0.454471055676557 0.142857142857142 0.0177945154831915 0.428129160909698 1.06625577812018 0.114781329917891 4.88854768743992 1 617 1879 False False 2.9322033898305 0.902272868706296 8.44763536260207 0.000564652738565782 6.83893826872173e-05 0.00203821603087665 0.999422299248989 0.998991090727643 0.999701459098715 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.0580478247511 1 233 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 10 3) Uncertain significance No change no 1 +Kanamycin rrs n.514A>C rrs_n.514A>C 1 non_coding_transcript_exon_variant 1472359 1 320 12 308 391 484 3155 20288 0.110265087422447 0.100139230742611 0.121038356569311 0.976699403042557 0.974555864055897 0.978708052885173 0.446857142857142 0.413570564549398 0.480502712329303 0.0375 0.0195242976900327 0.0645882567500664 0.0241935483870967 0.012562226153601 0.0418796282856026 0.250536151645501 0.127892921465632 0.444701352969795 1.03735877220053e-08 NA NA False True 5.1948291443465 4.51038663682232 5.97979793207449 0.00378907483422797 0.00195935600507549 0.00660938735246887 0.976699403042557 0.974555864055897 0.978708052885173 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 123 7 116 122 156 1485 6197 0.0759178593652769 0.0634408176368726 0.089969090950046 0.975444671808594 0.971334954298694 0.979109538916711 0.438848920863309 0.379644790543352 0.499370608106303 0.056910569105691 0.0231844435138147 0.11374417315423 0.0429447852760736 0.0174377977803271 0.0864787026722626 0.251822825960757 0.0988467799848484 0.537209157463255 2.51069838451247e-05 NA NA False True 0 0 0 0 0 1 0 3.26355003021669 2.53551106496753 4.1908876849304 0.00469168900804289 0.00188831996918794 0.0096426409025816 0.975444671808594 0.971334954298694 0.979109538916711 811 Not assoc w R Previous WHO guidance 4) Not assoc w R - Interim DOWN from NotAwR to NotAwRI yes Prev. WHO 3 +Kanamycin rrs n.514A>T rrs_n.514A>T 1 non_coding_transcript_exon_variant 1472359 1 8 1 7 3 10 3543 20762 0.000846023688663282 0.000174504417422474 0.00247043033885164 0.99951858270749 0.999114835261082 0.999769118326375 0.23076923076923 0.0503810734911515 0.53813153923404 0.125 0.0031597235312519 0.526509670875206 0.0909090909090909 0.00229897221381426 0.412779916988382 0.837143663561953 0.0185694633763124 6.51947783756715 1 193 1879 False False 1.7580016934801 0.310751426112262 6.8304991387246 0.00028216704288939 7.1438254941256e-06 0.00157112051380901 0.99951858270749 0.999114835261082 0.999769118326375 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 1 4 1606 6349 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.99937037620022 0.998388704765699 0.99982842290899 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.99401592025988 0.589389153087337 71.5 992 False False 0 0 0 0 0 0 0 0.98832503113325 0.0200561540991659 9.99322371223062 0 0 0.00229430020901157 0.99937037620022 0.998388704765699 0.99982842290899 17 3) Uncertain significance No change no 1 +Kanamycin rrs n.516C>T rrs_n.516C>T 1 non_coding_transcript_exon_variant 1472361 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.517C>T rrs_n.517C>T 1 non_coding_transcript_exon_variant 1472362 1 200 7 193 185 260 3361 20512 0.0521714608009024 0.0450831153504035 0.0600090321395718 0.987483150394762 0.985877027867413 0.988950589808751 0.415730337078651 0.369509211687257 0.463079164383108 0.035 0.0141855258984192 0.0707809983509772 0.0262172284644194 0.0106042538957508 0.0532691099723601 0.221350356805354 0.0877450327292758 0.465471340397466 1.05083585184087e-06 10 1879 True False 4.34248048886549 3.56331991927637 5.28283646020181 0.00207838479809976 0.0008360140076546 0.00427754945906263 0.987483150394762 0.985877027867413 0.988950589808751 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 82 5 77 119 114 1488 6239 0.074051026757934 0.0617246376524101 0.0879590804336062 0.98205572170628 0.978482498391111 0.985175966260066 0.510729613733905 0.444618213608248 0.576564588329649 0.0609756097560975 0.0200930005107692 0.136586772071582 0.042016806722689 0.0137813951901227 0.0953309297376472 0.272264697667923 0.0858549884662801 0.665078728584654 0.0015994137636801 12 992 False False 0 0 0 0 0 0 0 4.37677442935295 3.33402355872697 5.74512274017899 0.00334896182183523 0.00108826543603353 0.00779791929710371 0.98205572170628 0.978482498391111 0.985175966260066 537 Not assoc w R 3) Uncertain significance DOWN from NotAwR to Uncertain yes 2 +Kanamycin rrs n.51T>C rrs_n.51T>C 1 non_coding_transcript_exon_variant 1471896 0 0 0 0 2 8 3544 20764 0.000564015792442188 6.83122290578968e-05 0.00203591855262226 0.999614866165992 0.999241274614236 0.99983371235125 0.2 0.0252107263268333 0.556095462307641 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1291 1879 False False 1.46472911963882 0.151439261401278 7.34364495908934 0 0 0.0010403386792448 0.999614866165992 0.999241274614236 0.99983371235125 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 1607 6347 0 0 0.0022928741555424 0.99905556430033 0.997945503023207 0.999653332387469 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 635 992 False False 0 0 0 0 0 0 0 0 0 3.35786664322939 0 0 0.0022928741555424 0.99905556430033 0.997945503023207 0.999653332387469 104 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.529T>C rrs_n.529T>C 1 non_coding_transcript_exon_variant 1472374 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.-52T>G rrs_n.-52T>G 1 upstream_gene_variant 1471794 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1378 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 717 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.533G>T rrs_n.533G>T 1 non_coding_transcript_exon_variant 1472378 0 0 0 0 3 7 3543 20765 0.000846023688663282 0.000174504417422474 0.00247043033885164 0.999663007895243 0.999305791518941 0.999864501305137 0.3 0.0667395111777345 0.652452850059997 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1281 1879 False False 2.51179387927906 0.418907612454298 11.0084823914905 0 0 0.00104063215855229 0.999663007895243 0.999305791518941 0.999864501305137 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 6 1606 6347 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.99905556430033 0.997945503023207 0.999653332387469 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA 0 0 0.4592581264399 NA NA NA NA 627 992 False False 0 0 0 0 0 0 0 0.658675799086758 0.0143145764136424 5.43586332883977 0 0 0.00229430020901157 0.99905556430033 0.997945503023207 0.999653332387469 98 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.534T>C rrs_n.534T>C 1 non_coding_transcript_exon_variant 1472379 1 0 0 0 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1126 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1607 6349 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 486 992 False False 0 0 0 0 0 0 0 0 0 5.99028746746614 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 67 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.534T>G rrs_n.534T>G 1 non_coding_transcript_exon_variant 1472379 0 0 0 0 3 7 3543 20765 0.000846023688663282 0.000174504417422474 0.00247043033885164 0.999663007895243 0.999305791518941 0.999864501305137 0.3 0.0667395111777345 0.652452850059997 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1370 1879 False False 2.51179387927906 0.418907612454298 11.0084823914905 0 0 0.00104063215855229 0.999663007895243 0.999305791518941 0.999864501305137 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 5 1606 6348 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.999212970250275 0.99816429885228 0.999744405769873 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA 0 0 0.521823750104981 NA NA NA NA 709 992 False False 0 0 0 0 0 0 0 0.790535491905354 0.0167037613038365 7.07198409929284 0 0 0.00229430020901157 0.999212970250275 0.99816429885228 0.999744405769873 76 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.535G>C rrs_n.535G>C 1 non_coding_transcript_exon_variant 1472380 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1219 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 568 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 41 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.537G>A rrs_n.537G>A 1 non_coding_transcript_exon_variant 1472382 0 0 0 0 3 7 3543 20765 0.000846023688663282 0.000174504417422474 0.00247043033885164 0.999663007895243 0.999305791518941 0.999864501305137 0.3 0.0667395111777345 0.652452850059997 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1159 1879 False False 2.51179387927906 0.418907612454298 11.0084823914905 0 0 0.00104063215855229 0.999663007895243 0.999305791518941 0.999864501305137 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 5 1606 6348 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.999212970250275 0.99816429885228 0.999744405769873 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA 0 0 0.521823750104981 NA NA NA NA 515 992 False False 0 0 0 0 0 0 0 0.790535491905354 0.0167037613038365 7.07198409929284 0 0 0.00229430020901157 0.999212970250275 0.99816429885228 0.999744405769873 93 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.544G>A rrs_n.544G>A 1 non_coding_transcript_exon_variant 1472389 1 0 0 0 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1021 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 389 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 53 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.551A>T rrs_n.551A>T 1 non_coding_transcript_exon_variant 1472396 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1076 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 439 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 63 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.554A>G rrs_n.554A>G 1 non_coding_transcript_exon_variant 1472399 0 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1207 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 557 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.554A>T rrs_n.554A>T 1 non_coding_transcript_exon_variant 1472399 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.555C>T rrs_n.555C>T 1 non_coding_transcript_exon_variant 1472400 0 0 0 0 3 20 3543 20752 0.000846023688663282 0.000174504417422474 0.00247043033885164 0.999037165414981 0.998513369831025 0.9994117795557 0.130434782608695 0.0277515074227932 0.335889137537121 NA NA NA 0 0 0.168433470983085 NA NA NA NA 1103 1879 False False 0.878577476714648 0.167088202767378 2.96454731014534 0 0 0.00104063215855229 0.999037165414981 0.998513369831025 0.9994117795557 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 17 1606 6336 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.997324098850936 0.995719069008731 0.998440440224704 0.0555555555555555 0.00140555616736942 0.272943599673368 NA NA NA 0 0 0.195064322969093 NA NA NA NA 465 992 False False 0 0 0 0 0 0 0 0.232070910556003 0.00555318201394532 1.48344099579824 0 0 0.00229430020901157 0.997324098850936 0.995719069008731 0.998440440224704 176 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.556dupT rrs_n.556dupT 1 non_coding_transcript_exon_variant 1472400 1 1 0 1 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 227.636869136849 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 523 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.55C>T rrs_n.55C>T 1 non_coding_transcript_exon_variant 1471900 0 0 0 0 2 7 3544 20765 0.000564015792442188 6.83122290578968e-05 0.00203591855262226 0.999663007895243 0.999305791518941 0.999864501305137 0.222222222222222 0.0281449734778982 0.600093573716312 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1220 1879 False False 1.67405675588519 0.169596128350343 8.79734879915306 0 0 0.0010403386792448 0.999663007895243 0.999305791518941 0.999864501305137 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 1607 6347 0 0 0.0022928741555424 0.99905556430033 0.997945503023207 0.999653332387469 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 569 992 False False 0 0 0 0 0 0 0 0 0 3.35786664322939 0 0 0.0022928741555424 0.99905556430033 0.997945503023207 0.999653332387469 94 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.-55T>G rrs_n.-55T>G 1 upstream_gene_variant 1471791 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1080 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 442 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.560C>T rrs_n.560C>T 1 non_coding_transcript_exon_variant 1472405 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.0580478247511 1 233 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 2 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.567A>C rrs_n.567A>C 1 non_coding_transcript_exon_variant 1472412 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1104 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 466 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 30 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.567A>G rrs_n.567A>G 1 non_coding_transcript_exon_variant 1472412 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1221 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 570 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 14 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.569C>T rrs_n.569C>T 1 non_coding_transcript_exon_variant 1472414 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 6 3) Uncertain significance No change no 1 +Kanamycin rrs n.570T>G rrs_n.570T>G 1 non_coding_transcript_exon_variant 1472415 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1256 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 604 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 31 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.571C>T rrs_n.571C>T 1 non_coding_transcript_exon_variant 1472416 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1034 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 399 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 17 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.573T>C rrs_n.573T>C 1 non_coding_transcript_exon_variant 1472418 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1230 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 579 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 3 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.577T>C rrs_n.577T>C 1 non_coding_transcript_exon_variant 1472422 1 0 0 0 0 8 3546 20764 0 0 0.0010397522169524 0.999614866165992 0.999241274614236 0.99983371235125 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1292 1879 False False 0 0 3.43205141622579 0 0 0.0010397522169524 0.999614866165992 0.999241274614236 0.99983371235125 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 7 1607 6346 0 0 0.0022928741555424 0.998898158350385 0.997731111129242 0.999556891392146 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 636 992 False False 0 0 0 0 0 0 0 0 0 2.74289259224573 0 0 0.0022928741555424 0.998898158350385 0.997731111129242 0.999556891392146 46 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.-58_-57insT rrs_n.-58_-57insT 1 upstream_gene_variant 1471788 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Kanamycin rrs n.580T>C rrs_n.580T>C 1 non_coding_transcript_exon_variant 1472425 1 2 0 2 0 5 3546 20767 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 0 0 0.521823750104981 0 0 0.841886116991581 0 0 0.521823750104981 0 0 31.2131924627285 1 617 1879 False False 0 0 6.39361750002021 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 550 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 2 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.581T>G rrs_n.581T>G 1 non_coding_transcript_exon_variant 1472426 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1317 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 661 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.590T>C rrs_n.590T>C 1 non_coding_transcript_exon_variant 1472435 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1361 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 700 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.592T>A rrs_n.592T>A 1 non_coding_transcript_exon_variant 1472437 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1282 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 628 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.593T>C rrs_n.593T>C 1 non_coding_transcript_exon_variant 1472438 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1371 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 710 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.594C>T rrs_n.594C>T 1 non_coding_transcript_exon_variant 1472439 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1362 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 701 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.5G>T rrs_n.5G>T 1 non_coding_transcript_exon_variant 1471850 1 6 0 6 1 10 3545 20762 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.99951858270749 0.999114835261082 0.999769118326375 0.0909090909090909 0.00229897221381426 0.412779916988382 0 0 0.4592581264399 0 0 0.30849710781876 0 0 4.97630854990859 0.602105081678401 136 1879 False False 0.585669957686882 0.0134948626376594 4.11922590459154 0 0 0.00104004536542481 0.99951858270749 0.999114835261082 0.999769118326375 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 611 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 11 3) Uncertain significance No change no 1 +Kanamycin rrs n.601T>A rrs_n.601T>A 1 non_coding_transcript_exon_variant 1472446 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1160 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 516 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.602C>T rrs_n.602C>T 1 non_coding_transcript_exon_variant 1472447 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1143 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 501 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.603T>C rrs_n.603T>C 1 non_coding_transcript_exon_variant 1472448 1 2 0 2 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 31.21472012401 1 617 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 153.76339448854 1 233 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 1 3) Uncertain significance No change no 1 +Kanamycin rrs n.605A>G rrs_n.605A>G 1 non_coding_transcript_exon_variant 1472450 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1396 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 734 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.606C>G rrs_n.606C>G 1 non_coding_transcript_exon_variant 1472451 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1327 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 670 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.607G>A rrs_n.607G>A 1 non_coding_transcript_exon_variant 1472452 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1372 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 711 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.613A>C rrs_n.613A>C 1 non_coding_transcript_exon_variant 1472458 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.616G>C rrs_n.616G>C 1 non_coding_transcript_exon_variant 1472461 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1077 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 440 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.617T>C rrs_n.617T>C 1 non_coding_transcript_exon_variant 1472462 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1022 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 390 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.619A>G rrs_n.619A>G 1 non_coding_transcript_exon_variant 1472464 1 0 0 0 0 6 3546 20766 0 0 0.0010397522169524 0.999711149624494 0.999371401166804 0.999893989862555 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1318 1879 False False 0 0 4.9758630843129 0 0 0.0010397522169524 0.999711149624494 0.999371401166804 0.999893989862555 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 1607 6347 0 0 0.0022928741555424 0.99905556430033 0.997945503023207 0.999653332387469 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 662 992 False False 0 0 0 0 0 0 0 0 0 3.35786664322939 0 0 0.0022928741555424 0.99905556430033 0.997945503023207 0.999653332387469 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.619A>T rrs_n.619A>T 1 non_coding_transcript_exon_variant 1472464 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.626G>A rrs_n.626G>A 1 non_coding_transcript_exon_variant 1472471 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1344 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 685 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 2 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.628G>T rrs_n.628G>T 1 non_coding_transcript_exon_variant 1472473 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1198 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 551 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.629C>G rrs_n.629C>G 1 non_coding_transcript_exon_variant 1472474 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1161 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 517 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.633A>C rrs_n.633A>C 1 non_coding_transcript_exon_variant 1472478 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1293 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.637G>A rrs_n.637G>A 1 non_coding_transcript_exon_variant 1472482 1 3 0 3 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 14.1782880202046 1 617 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.57085126512166 1 233 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.639A>C rrs_n.639A>C 1 non_coding_transcript_exon_variant 1472484 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1244 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 591 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.639A>T rrs_n.639A>T 1 non_coding_transcript_exon_variant 1472484 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1373 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 712 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.641A>G rrs_n.641A>G 1 non_coding_transcript_exon_variant 1472486 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1023 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 391 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.643dupT rrs_n.643dupT 1 non_coding_transcript_exon_variant 1472487 1 8 0 8 0 8 3546 20764 0 0 0.0010397522169524 0.999614866165992 0.999241274614236 0.99983371235125 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 3.43205141622579 0.612907213659498 156 1879 False False 0 0 3.43205141622579 0 0 0.0010397522169524 0.999614866165992 0.999241274614236 0.99983371235125 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 13 3) Uncertain significance No change no 1 +Kanamycin rrs n.644A>G rrs_n.644A>G 1 non_coding_transcript_exon_variant 1472489 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.644A>T rrs_n.644A>T 1 non_coding_transcript_exon_variant 1472489 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1345 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 686 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 4 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.649A>G rrs_n.649A>G 1 non_coding_transcript_exon_variant 1472494 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1222 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 571 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 11 3) Uncertain significance No change no 1 +Kanamycin rrs n.649A>T rrs_n.649A>T 1 non_coding_transcript_exon_variant 1472494 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1319 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 663 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.650C>T rrs_n.650C>T 1 non_coding_transcript_exon_variant 1472495 1 1 0 1 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 227.636869136849 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 744 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 4 3) Uncertain significance No change no 1 +Kanamycin rrs n.651T>A rrs_n.651T>A 1 non_coding_transcript_exon_variant 1472496 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1384 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 723 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 3 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.651T>G rrs_n.651T>G 1 non_coding_transcript_exon_variant 1472496 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1057 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 420 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 6 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.652G>T rrs_n.652G>T 1 non_coding_transcript_exon_variant 1472497 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1184 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 537 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.653C>T rrs_n.653C>T 1 non_coding_transcript_exon_variant 1472498 1 0 0 0 0 5 3546 20767 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1374 1879 False False 0 0 6.39361750002021 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 1607 6348 0 0 0.0022928741555424 0.999212970250275 0.99816429885228 0.999744405769873 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 713 992 False False 0 0 0 0 0 0 0 0 0 4.31499754664604 0 0 0.0022928741555424 0.999212970250275 0.99816429885228 0.999744405769873 13 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.655G>C rrs_n.655G>C 1 non_coding_transcript_exon_variant 1472500 1 4 0 4 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 8.87534793394977 1 617 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 2 3) Uncertain significance No change no 1 +Kanamycin rrs n.656G>C rrs_n.656G>C 1 non_coding_transcript_exon_variant 1472501 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.-65G>A rrs_n.-65G>A 1 upstream_gene_variant 1471781 1 6 0 6 0 8 3546 20764 0 0 0.0010397522169524 0.999614866165992 0.999241274614236 0.99983371235125 0 0 0.369416647552819 0 0 0.4592581264399 0 0 0.369416647552819 0 0 4.97538388373 0.602095848123551 131 1879 False False 0 0 3.43205141622579 0 0 0.0010397522169524 0.999614866165992 0.999241274614236 0.99983371235125 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 21.0547398420152 1 233 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 5 3) Uncertain significance No change no 1 +Kanamycin rrs n.660G>T rrs_n.660G>T 1 non_coding_transcript_exon_variant 1472505 1 1 1 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.150201697158088 Inf 0.14581791265729 60 1879 False False Inf 0.150201697158088 Inf 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Kanamycin rrs n.662C>G rrs_n.662C>G 1 non_coding_transcript_exon_variant 1472507 0 0 0 0 1 5 3545 20767 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999759291353745 0.999438356476751 0.999921838086342 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1231 1879 False False 1.17162200282087 0.0247643691956443 10.4748703386698 0 0 0.00104004536542481 0.999759291353745 0.999438356476751 0.999921838086342 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1607 6349 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 580 992 False False 0 0 0 0 0 0 0 0 0 5.99028746746614 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 44 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.662C>T rrs_n.662C>T 1 non_coding_transcript_exon_variant 1472507 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1208 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 558 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 4 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.663T>C rrs_n.663T>C 1 non_coding_transcript_exon_variant 1472508 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1089 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 453 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 1 3) Uncertain significance No change no 1 +Kanamycin rrs n.66C>A rrs_n.66C>A 1 non_coding_transcript_exon_variant 1471911 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1294 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 637 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 27 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.672T>A rrs_n.672T>A 1 non_coding_transcript_exon_variant 1472517 0 0 0 0 1 9 3545 20763 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999566724436741 0.999177668076772 0.99980186029375 0.1 0.00252857854446178 0.445016117028195 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1058 1879 False False 0.650775740479548 0.0148464649376449 4.69895288822098 0 0 0.00104004536542481 0.999566724436741 0.999177668076772 0.99980186029375 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 7 1607 6346 0 0 0.0022928741555424 0.998898158350385 0.997731111129242 0.999556891392146 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 421 992 False False 0 0 0 0 0 0 0 0 0 2.74289259224573 0 0 0.0022928741555424 0.998898158350385 0.997731111129242 0.999556891392146 73 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.673G>A rrs_n.673G>A 1 non_coding_transcript_exon_variant 1472518 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1385 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 724 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 4 3) Uncertain significance No change no 1 +Kanamycin rrs n.673G>C rrs_n.673G>C 1 non_coding_transcript_exon_variant 1472518 0 0 0 0 1 4 3545 20768 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999807433082996 0.99950702628237 0.999947529583666 0.2 0.00505076337946806 0.716417936118089 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1185 1879 False False 1.46459802538787 0.0297312351170663 14.8120229375093 0 0 0.00104004536542481 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 538 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 5 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.673G>T rrs_n.673G>T 1 non_coding_transcript_exon_variant 1472518 1 0 0 0 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1409 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 745 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 66 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.-67T>C rrs_n.-67T>C 1 upstream_gene_variant 1471779 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Kanamycin rrs n.685G>A rrs_n.685G>A 1 non_coding_transcript_exon_variant 1472530 0 0 0 0 3 19 3543 20753 0.000846023688663282 0.000174504417422474 0.00247043033885164 0.999085307144232 0.998571960712224 0.999449208150065 0.136363636363636 0.0290558511287467 0.349122097257408 NA NA NA 0 0 0.176466911806965 NA NA NA NA 1170 1879 False False 0.924862961807567 0.175189543374916 3.14449204349987 0 0 0.00104063215855229 0.999085307144232 0.998571960712224 0.999449208150065 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 16 1606 6337 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.997481504800881 0.995913335169992 0.998559798442438 0.0588235294117647 0.00148817439126663 0.28688939666722 NA NA NA 0 0 0.205907214207822 NA NA NA NA 524 992 False False 0 0 0 0 0 0 0 0.246614259028642 0.00588077973628894 1.58990388049201 0 0 0.00229430020901157 0.997481504800881 0.995913335169992 0.998559798442438 169 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.-68G>T rrs_n.-68G>T 1 upstream_gene_variant 1471778 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.692C>T rrs_n.692C>T 1 non_coding_transcript_exon_variant 1472537 0 0 0 0 3 10 3543 20762 0.000846023688663282 0.000174504417422474 0.00247043033885164 0.99951858270749 0.999114835261082 0.999769118326375 0.23076923076923 0.0503810734911515 0.53813153923404 NA NA NA 0 0 0.30849710781876 NA NA NA NA 1386 1879 False False 1.7580016934801 0.310751426112262 6.8304991387246 0 0 0.00104063215855229 0.99951858270749 0.999114835261082 0.999769118326375 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 8 1606 6345 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.99874075240044 0.997520296036287 0.99945619445686 0.111111111111111 0.00280913674659921 0.482496514917337 NA NA NA 0 0 0.369416647552819 NA NA NA NA 725 992 False False 0 0 0 0 0 0 0 0.493851183063511 0.0111262820523154 3.6883573216039 0 0 0.00229430020901157 0.99874075240044 0.997520296036287 0.99945619445686 146 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.696T>G rrs_n.696T>G 1 non_coding_transcript_exon_variant 1472541 0 0 0 0 3 7 3543 20765 0.000846023688663282 0.000174504417422474 0.00247043033885164 0.999663007895243 0.999305791518941 0.999864501305137 0.3 0.0667395111777345 0.652452850059997 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1127 1879 False False 2.51179387927906 0.418907612454298 11.0084823914905 0 0 0.00104063215855229 0.999663007895243 0.999305791518941 0.999864501305137 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 5 1606 6348 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.999212970250275 0.99816429885228 0.999744405769873 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA 0 0 0.521823750104981 NA NA NA NA 487 992 False False 0 0 0 0 0 0 0 0.790535491905354 0.0167037613038365 7.07198409929284 0 0 0.00229430020901157 0.999212970250275 0.99816429885228 0.999744405769873 42 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.698T>C rrs_n.698T>C 1 non_coding_transcript_exon_variant 1472543 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.699C>A rrs_n.699C>A 1 non_coding_transcript_exon_variant 1472544 1 0 0 0 0 7 3546 20765 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1117 1879 False False 0 0 4.06480602430196 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 1607 6348 0 0 0.0022928741555424 0.999212970250275 0.99816429885228 0.999744405769873 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 479 992 False False 0 0 0 0 0 0 0 0 0 4.31499754664604 0 0 0.0022928741555424 0.999212970250275 0.99816429885228 0.999744405769873 163 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.699C>G rrs_n.699C>G 1 non_coding_transcript_exon_variant 1472544 0 0 0 0 3 4 3543 20768 0.000846023688663282 0.000174504417422474 0.00247043033885164 0.999807433082996 0.99950702628237 0.999947529583666 0.428571428571428 0.0989882784425078 0.815948432359917 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1397 1879 False False 4.39627434377646 0.643655924286285 26.0133486448229 0 0 0.00104063215855229 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 3 1606 6350 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.999527782150165 0.998620605323549 0.999902606737868 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 735 992 False False 0 0 0 0 0 0 0 1.31797426317974 0.0250900413291082 16.4244635399174 0 0 0.00229430020901157 0.999527782150165 0.998620605323549 0.999902606737868 14 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.699C>T rrs_n.699C>T 1 non_coding_transcript_exon_variant 1472544 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Kanamycin rrs n.69A>G rrs_n.69A>G 1 non_coding_transcript_exon_variant 1471914 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1245 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 592 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.-69C>A rrs_n.-69C>A 1 upstream_gene_variant 1471777 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.-69C>T rrs_n.-69C>T 1 upstream_gene_variant 1471777 1 4 0 4 0 7 3546 20765 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 0 0 0.409616397225003 0 0 0.602364635616474 0 0 0.409616397225003 0 0 8.87406596942854 1 617 1879 False False 0 0 4.06480602430196 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 5 1607 6348 0 0 0.0022928741555424 0.999212970250275 0.99816429885228 0.999744405769873 0 0 0.521823750104981 0 0 0.841886116991581 0 0 0.521823750104981 0 0 21.0481238920082 1 233 992 False False 0 0 0 0 0 0 0 0 0 4.31499754664604 0 0 0.0022928741555424 0.999212970250275 0.99816429885228 0.999744405769873 14 3) Uncertain significance No change no 1 +Kanamycin rrs n.700A>T rrs_n.700A>T 1 non_coding_transcript_exon_variant 1472545 0 0 0 0 3 11 3543 20761 0.000846023688663282 0.000174504417422474 0.00247043033885164 0.99947044097824 0.999052670645628 0.99973561734751 0.214285714285714 0.0465792878898673 0.507975677048471 NA NA NA 0 0 0.284914152918154 NA NA NA NA 1398 1879 False False 1.59810638134092 0.286129216218252 6.05369020552991 0 0 0.00104063215855229 0.99947044097824 0.999052670645628 0.99973561734751 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 8 1606 6345 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.99874075240044 0.997520296036287 0.99945619445686 0.111111111111111 0.00280913674659921 0.482496514917337 NA NA NA 0 0 0.369416647552819 NA NA NA NA 736 992 False False 0 0 0 0 0 0 0 0.493851183063511 0.0111262820523154 3.6883573216039 0 0 0.00229430020901157 0.99874075240044 0.997520296036287 0.99945619445686 180 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.703A>C rrs_n.703A>C 1 non_coding_transcript_exon_variant 1472548 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.704G>A rrs_n.704G>A 1 non_coding_transcript_exon_variant 1472549 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1328 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 671 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 16 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.708C>T rrs_n.708C>T 1 non_coding_transcript_exon_variant 1472553 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.-70G>C rrs_n.-70G>C 1 upstream_gene_variant 1471776 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 2 3) Uncertain significance No change no 1 +Kanamycin rrs n.712G>A rrs_n.712G>A 1 non_coding_transcript_exon_variant 1472557 0 0 0 0 3 15 3543 20757 0.000846023688663282 0.000174504417422474 0.00247043033885164 0.999277874061236 0.998809242329947 0.999595777053137 0.166666666666666 0.0357850831215746 0.414177491394774 NA NA NA 0 0 0.218019360910534 NA NA NA NA 1232 1879 False False 1.17171888230313 0.21731903178309 4.14510869911865 0 0 0.00104063215855229 0.999277874061236 0.998809242329947 0.999595777053137 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 10 1606 6343 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.99842594050055 0.997107159926049 0.999244927346731 0.0909090909090909 0.00229897221381426 0.412779916988382 NA NA NA 0 0 0.30849710781876 NA NA NA NA 581 992 False False 0 0 0 0 0 0 0 0.394956413449564 0.00909874325261868 2.78012630925377 0 0 0.00229430020901157 0.99842594050055 0.997107159926049 0.999244927346731 73 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.713G>A rrs_n.713G>A 1 non_coding_transcript_exon_variant 1472558 1 0 0 0 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1090 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1607 6349 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 454 992 False False 0 0 0 0 0 0 0 0 0 5.99028746746614 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 17 3) Uncertain significance No change no 1 +Kanamycin rrs n.717C>T rrs_n.717C>T 1 non_coding_transcript_exon_variant 1472562 1 1 1 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.150201697158088 Inf 0.14581791265729 60 1879 False False Inf 0.150201697158088 Inf 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.101367337197729 Inf 0.201884422110552 36.5 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.721G>A rrs_n.721G>A 1 non_coding_transcript_exon_variant 1472566 1 0 0 0 0 5 3546 20767 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1035 1879 False False 0 0 6.39361750002021 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1607 6349 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 400 992 False False 0 0 0 0 0 0 0 0 0 5.99028746746614 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 159 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.724G>A rrs_n.724G>A 1 non_coding_transcript_exon_variant 1472569 1 0 0 0 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1199 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1607 6349 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 552 992 False False 0 0 0 0 0 0 0 0 0 5.99028746746614 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 17 3) Uncertain significance No change no 1 +Kanamycin rrs n.725G>A rrs_n.725G>A 1 non_coding_transcript_exon_variant 1472570 0 0 0 0 2 13 3544 20759 0.000564015792442188 6.83122290578968e-05 0.00203591855262226 0.999374157519738 0.998930028080923 0.99966672449503 0.133333333333333 0.0165759134400836 0.404602696603372 NA NA NA 0 0 0.24705263800047 NA NA NA NA 1387 1879 False False 0.901154714360132 0.0986889742493136 3.98329702983899 0 0 0.0010403386792448 0.999374157519738 0.998930028080923 0.99966672449503 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 9 1606 6344 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.998583346450495 0.997312461277908 0.999352017626566 0.1 0.00252857854446178 0.445016117028195 NA NA NA 0 0 0.336267116879942 NA NA NA NA 726 992 False False 0 0 0 0 0 0 0 0.438909644389096 0.0100110022233902 3.17195020844629 0 0 0.00229430020901157 0.998583346450495 0.997312461277908 0.999352017626566 39 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.726G>A rrs_n.726G>A 1 non_coding_transcript_exon_variant 1472571 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1295 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 638 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 3 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.726G>C rrs_n.726G>C 1 non_coding_transcript_exon_variant 1472571 0 0 0 0 2 19 3544 20753 0.000564015792442188 6.83122290578968e-05 0.00203591855262226 0.999085307144232 0.998571960712224 0.999449208150065 0.0952380952380952 0.0117493178844458 0.303774406913924 NA NA NA 0 0 0.176466911806965 NA NA NA NA 1296 1879 False False 0.61640133064037 0.0695900288242651 2.55665704960093 0 0 0.0010403386792448 0.999085307144232 0.998571960712224 0.999449208150065 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 14 1606 6339 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.997796316700771 0.996305355363671 0.99879471848905 0.0666666666666666 0.0016864302413527 0.319484566578303 NA NA NA 0 0 0.231635761650116 NA NA NA NA 639 992 False False 0 0 0 0 0 0 0 0.281933819605052 0.00666713453414386 1.85585385542327 0 0 0.00229430020901157 0.997796316700771 0.996305355363671 0.99879471848905 239 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.727T>C rrs_n.727T>C 1 non_coding_transcript_exon_variant 1472572 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.728C>T rrs_n.728C>T 1 non_coding_transcript_exon_variant 1472573 1 0 0 0 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1144 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 502 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 45 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.72G>C rrs_n.72G>C 1 non_coding_transcript_exon_variant 1471917 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.730C>T rrs_n.730C>T 1 non_coding_transcript_exon_variant 1472575 0 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1233 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 582 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 2 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.734G>A rrs_n.734G>A 1 non_coding_transcript_exon_variant 1472579 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1024 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 392 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 5 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.734G>C rrs_n.734G>C 1 non_coding_transcript_exon_variant 1472579 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1047 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 100 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.734G>T rrs_n.734G>T 1 non_coding_transcript_exon_variant 1472579 0 0 0 0 3 13 3543 20759 0.000846023688663282 0.000174504417422474 0.00247043033885164 0.999374157519738 0.998930028080923 0.99966672449503 0.1875 0.0404737339059459 0.456456546231611 NA NA NA 0 0 0.24705263800047 NA NA NA NA 1266 1879 False False 1.3521135934345 0.247014348103655 4.92433738571517 0 0 0.00104063215855229 0.999374157519738 0.998930028080923 0.99966672449503 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 10 1606 6343 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.99842594050055 0.997107159926049 0.999244927346731 0.0909090909090909 0.00229897221381426 0.412779916988382 NA NA NA 0 0 0.30849710781876 NA NA NA NA 612 992 False False 0 0 0 0 0 0 0 0.394956413449564 0.00909874325261868 2.78012630925377 0 0 0.00229430020901157 0.99842594050055 0.997107159926049 0.999244927346731 156 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.735C>A rrs_n.735C>A 1 non_coding_transcript_exon_variant 1472580 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1320 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 664 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.735C>G rrs_n.735C>G 1 non_coding_transcript_exon_variant 1472580 1 3 0 3 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 14.1782880202046 1 617 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 2 3) Uncertain significance No change no 1 +Kanamycin rrs n.735C>T rrs_n.735C>T 1 non_coding_transcript_exon_variant 1472580 1 1 0 1 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 227.636869136849 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 98 3) Uncertain significance No change no 1 +Kanamycin rrs n.736A>C rrs_n.736A>C 1 non_coding_transcript_exon_variant 1472581 1 0 0 0 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1118 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1607 6349 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 480 992 False False 0 0 0 0 0 0 0 0 0 5.99028746746614 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 27 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.736A>T rrs_n.736A>T 1 non_coding_transcript_exon_variant 1472581 0 0 0 0 3 19 3543 20753 0.000846023688663282 0.000174504417422474 0.00247043033885164 0.999085307144232 0.998571960712224 0.999449208150065 0.136363636363636 0.0290558511287467 0.349122097257408 NA NA NA 0 0 0.176466911806965 NA NA NA NA 1209 1879 False False 0.924862961807567 0.175189543374916 3.14449204349987 0 0 0.00104063215855229 0.999085307144232 0.998571960712224 0.999449208150065 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 13 1606 6340 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.997953722650716 0.996503345413809 0.998910007694291 0.0714285714285714 0.00180678065912538 0.338684489931821 NA NA NA 0 0 0.24705263800047 NA NA NA NA 559 992 False False 0 0 0 0 0 0 0 0.30366893380592 0.00714464649823022 2.02468686659141 0 0 0.00229430020901157 0.997953722650716 0.996503345413809 0.998910007694291 227 3) Uncertain significance No change no 1 +Kanamycin rrs n.737G>A rrs_n.737G>A 1 non_coding_transcript_exon_variant 1472582 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1399 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 737 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 6 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.738T>A rrs_n.738T>A 1 non_coding_transcript_exon_variant 1472583 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1036 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 401 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.739A>T rrs_n.739A>T 1 non_coding_transcript_exon_variant 1472584 1 0 0 0 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1091 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1607 6349 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 455 992 False False 0 0 0 0 0 0 0 0 0 5.99028746746614 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 24 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.73A>T rrs_n.73A>T 1 non_coding_transcript_exon_variant 1471918 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1423 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 760 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.746G>A rrs_n.746G>A 1 non_coding_transcript_exon_variant 1472591 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1246 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 593 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 8 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.-74delG rrs_n.-74delG 1 upstream_gene_variant 1471771 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1202 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 3) Uncertain significance No change no 1 +Kanamycin rrs n.-74G>A rrs_n.-74G>A 1 upstream_gene_variant 1471772 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.-74G>T rrs_n.-74G>T 1 upstream_gene_variant 1471772 1 1 0 1 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 227.636869136849 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 153.787547206498 1 233 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 7 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.751G>T rrs_n.751G>T 1 non_coding_transcript_exon_variant 1472596 1 0 0 0 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1247 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 594 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 29 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.752G>A rrs_n.752G>A 1 non_coding_transcript_exon_variant 1472597 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1171 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 525 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 8 3) Uncertain significance No change no 1 +Kanamycin rrs n.753A>C rrs_n.753A>C 1 non_coding_transcript_exon_variant 1472598 0 0 0 0 3 16 3543 20756 0.000846023688663282 0.000174504417422474 0.00247043033885164 0.999229732331985 0.998749434152838 0.999559663409708 0.157894736842105 0.0338262490017646 0.395784551266674 NA NA NA 0 0 0.205907214207822 NA NA NA NA 1105 1879 False False 1.09843353090601 0.204996128215496 3.84028655480137 0 0 0.00104063215855229 0.999229732331985 0.998749434152838 0.999559663409708 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 11 1606 6342 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.998268534550606 0.996904046831145 0.999135351755422 0.0833333333333333 0.00210759323186022 0.384796165150944 NA NA NA 0 0 0.284914152918154 NA NA NA NA 467 992 False False 0 0 0 0 0 0 0 0.358994679044492 0.00833869553663541 2.4734928655095 0 0 0.00229430020901157 0.998268534550606 0.996904046831145 0.999135351755422 224 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.753A>T rrs_n.753A>T 1 non_coding_transcript_exon_variant 1472598 1 0 0 0 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1119 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 481 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 33 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.754G>A rrs_n.754G>A 1 non_coding_transcript_exon_variant 1472599 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1388 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 727 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.754G>T rrs_n.754G>T 1 non_coding_transcript_exon_variant 1472599 1 0 0 0 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1186 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 539 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 175 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.762G>A rrs_n.762G>A 1 non_coding_transcript_exon_variant 1472607 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1172 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 526 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 18 3) Uncertain significance No change no 1 +Kanamycin rrs n.763T>C rrs_n.763T>C 1 non_coding_transcript_exon_variant 1472608 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.767G>T rrs_n.767G>T 1 non_coding_transcript_exon_variant 1472612 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1025 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 393 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 7 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.769G>T rrs_n.769G>T 1 non_coding_transcript_exon_variant 1472614 1 0 0 0 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1283 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 629 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 32 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.771G>A rrs_n.771G>A 1 non_coding_transcript_exon_variant 1472616 0 0 0 0 1 14 3545 20758 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999326015790487 0.998869427329123 0.999631479131688 0.0666666666666666 0.0016864302413527 0.319484566578303 NA NA NA 0 0 0.231635761650116 NA NA NA NA 1305 1879 False False 0.418255087648599 0.00989216454442892 2.7507499999788 0 0 0.00104004536542481 0.999326015790487 0.998869427329123 0.999631479131688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 10 1606 6343 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.99842594050055 0.997107159926049 0.999244927346731 0.0909090909090909 0.00229897221381426 0.412779916988382 NA NA NA 0 0 0.30849710781876 NA NA NA NA 648 992 False False 0 0 0 0 0 0 0 0.394956413449564 0.00909874325261868 2.78012630925377 0 0 0.00229430020901157 0.99842594050055 0.997107159926049 0.999244927346731 221 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.78_80delTCTinsCC rrs_n.78_80delTCTinsCC 1 non_coding_transcript_exon_variant 1471923 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1128 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 488 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.78T>C rrs_n.78T>C 1 non_coding_transcript_exon_variant 1471923 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1267 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 613 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 4 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.-78T>C rrs_n.-78T>C 1 upstream_gene_variant 1471768 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.799C>A rrs_n.799C>A 1 non_coding_transcript_exon_variant 1472644 1 0 0 0 0 9 3546 20763 0 0 0.0010397522169524 0.999566724436741 0.999177668076772 0.99980186029375 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1129 1879 False False 0 0 2.96786458045639 0 0 0.0010397522169524 0.999566724436741 0.999177668076772 0.99980186029375 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 8 1607 6345 0 0 0.0022928741555424 0.99874075240044 0.997520296036287 0.99945619445686 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 489 992 False False 0 0 0 0 0 0 0 0 0 2.31577290672845 0 0 0.0022928741555424 0.99874075240044 0.997520296036287 0.99945619445686 3 3) Uncertain significance No change no 1 +Kanamycin rrs n.799C>T rrs_n.799C>T 1 non_coding_transcript_exon_variant 1472644 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1306 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 649 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 17 3) Uncertain significance No change no 1 +Kanamycin rrs n.-79T>C rrs_n.-79T>C 1 upstream_gene_variant 1471767 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.-7G>A rrs_n.-7G>A 1 upstream_gene_variant 1471839 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1332 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.808C>T rrs_n.808C>T 1 non_coding_transcript_exon_variant 1472653 1 3 1 2 1 2 3545 20770 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999903716541498 0.99965223478104 0.999988339413789 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 2.92947813822284 0.0496406430315194 56.2247306595764 0.376778779427543 114.5 1879 False False 2.92947813822284 0.0496406430315194 56.2247306595764 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Kanamycin rrs n.80T>C rrs_n.80T>C 1 non_coding_transcript_exon_variant 1471925 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1329 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 672 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.-81_-80insG rrs_n.-81_-80insG 1 upstream_gene_variant 1471765 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Kanamycin rrs n.810G>A rrs_n.810G>A 1 non_coding_transcript_exon_variant 1472655 1 0 0 0 0 8 3546 20764 0 0 0.0010397522169524 0.999614866165992 0.999241274614236 0.99983371235125 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1187 1879 False False 0 0 3.43205141622579 0 0 0.0010397522169524 0.999614866165992 0.999241274614236 0.99983371235125 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 1607 6348 0 0 0.0022928741555424 0.999212970250275 0.99816429885228 0.999744405769873 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 540 992 False False 0 0 0 0 0 0 0 0 0 4.31499754664604 0 0 0.0022928741555424 0.999212970250275 0.99816429885228 0.999744405769873 42 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.810G>T rrs_n.810G>T 1 non_coding_transcript_exon_variant 1472655 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1307 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 650 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 46 3) Uncertain significance No change no 1 +Kanamycin rrs n.813G>A rrs_n.813G>A 1 non_coding_transcript_exon_variant 1472658 1 0 0 0 0 7 3546 20765 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1308 1879 False False 0 0 4.06480602430196 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1607 6349 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 651 992 False False 0 0 0 0 0 0 0 0 0 5.99028746746614 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 35 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.814G>A rrs_n.814G>A 1 non_coding_transcript_exon_variant 1472659 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1078 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 441 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 2 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.815T>C rrs_n.815T>C 1 non_coding_transcript_exon_variant 1472660 1 0 0 0 0 5 3546 20767 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1106 1879 False False 0 0 6.39361750002021 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 1607 6348 0 0 0.0022928741555424 0.999212970250275 0.99816429885228 0.999744405769873 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 468 992 False False 0 0 0 0 0 0 0 0 0 4.31499754664604 0 0 0.0022928741555424 0.999212970250275 0.99816429885228 0.999744405769873 43 3) Uncertain significance No change no 1 +Kanamycin rrs n.816A>G rrs_n.816A>G 1 non_coding_transcript_exon_variant 1472661 1 0 0 0 0 8 3546 20764 0 0 0.0010397522169524 0.999614866165992 0.999241274614236 0.99983371235125 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1234 1879 False False 0 0 3.43205141622579 0 0 0.0010397522169524 0.999614866165992 0.999241274614236 0.99983371235125 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 1607 6348 0 0 0.0022928741555424 0.999212970250275 0.99816429885228 0.999744405769873 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 583 992 False False 0 0 0 0 0 0 0 0 0 4.31499754664604 0 0 0.0022928741555424 0.999212970250275 0.99816429885228 0.999744405769873 41 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.81C>T rrs_n.81C>T 1 non_coding_transcript_exon_variant 1471926 0 0 0 0 1 1 3545 20771 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999951858270749 0.999731800967312 0.999998781157685 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1162 1879 False False 5.8592383638928 0.0746220616644107 458.169367733398 0 0 0.00104004536542481 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 518 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 2 3) Uncertain significance No change no 1 +Kanamycin rrs n.820G>A rrs_n.820G>A 1 non_coding_transcript_exon_variant 1472665 1 0 0 0 0 5 3546 20767 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1375 1879 False False 0 0 6.39361750002021 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 714 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 5 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.824_825insTAGA rrs_n.824_825insTAGA 1 non_coding_transcript_exon_variant 1472669 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1346 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 687 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.824_825insTAGG rrs_n.824_825insTAGG 1 non_coding_transcript_exon_variant 1472669 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1120 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 482 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 2 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.828T>A rrs_n.828T>A 1 non_coding_transcript_exon_variant 1472673 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1107 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 469 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 3 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.828T>C rrs_n.828T>C 1 non_coding_transcript_exon_variant 1472673 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1130 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 490 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.829T>A rrs_n.829T>A 1 non_coding_transcript_exon_variant 1472674 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1330 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 673 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.-82C>T rrs_n.-82C>T 1 upstream_gene_variant 1471764 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.830T>A rrs_n.830T>A 1 non_coding_transcript_exon_variant 1472675 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1108 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 470 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.830T>C rrs_n.830T>C 1 non_coding_transcript_exon_variant 1472675 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1200 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 553 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 10 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.830T>G rrs_n.830T>G 1 non_coding_transcript_exon_variant 1472675 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1268 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 614 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.832C>A rrs_n.832C>A 1 non_coding_transcript_exon_variant 1472677 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1248 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 595 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 8 3) Uncertain significance No change no 1 +Kanamycin rrs n.833_834delTTinsGCC rrs_n.833_834delTTinsGCC 1 non_coding_transcript_exon_variant 1472678 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1235 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 584 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 2 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.833T>G rrs_n.833T>G 1 non_coding_transcript_exon_variant 1472678 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1297 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 640 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 2 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.834T>C rrs_n.834T>C 1 non_coding_transcript_exon_variant 1472679 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1376 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 715 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 2 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.836C>G rrs_n.836C>G 1 non_coding_transcript_exon_variant 1472681 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.837T>A rrs_n.837T>A 1 non_coding_transcript_exon_variant 1472682 1 0 0 0 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1059 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1607 6349 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 422 992 False False 0 0 0 0 0 0 0 0 0 5.99028746746614 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 11 3) Uncertain significance No change no 1 +Kanamycin rrs n.837T>G rrs_n.837T>G 1 non_coding_transcript_exon_variant 1472682 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance No change no 1 +Kanamycin rrs n.838T>C rrs_n.838T>C 1 non_coding_transcript_exon_variant 1472683 1 0 0 0 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1109 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1607 6349 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 471 992 False False 0 0 0 0 0 0 0 0 0 5.99028746746614 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 11 3) Uncertain significance No change no 1 +Kanamycin rrs n.839_845delGGGATCCinsA rrs_n.839_845delGGGATCCinsA 1 non_coding_transcript_exon_variant 1472684 1 0 0 0 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1331 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 674 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 3 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.839_845delGGGATCCinsTA rrs_n.839_845delGGGATCCinsTA 1 non_coding_transcript_exon_variant 1472684 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1188 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 541 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 2 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.840G>T rrs_n.840G>T 1 non_coding_transcript_exon_variant 1472685 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1347 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 688 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.841G>T rrs_n.841G>T 1 non_coding_transcript_exon_variant 1472686 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1389 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 728 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 2 3) Uncertain significance No change no 1 +Kanamycin rrs n.842A>G rrs_n.842A>G 1 non_coding_transcript_exon_variant 1472687 1 1 0 1 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 227.625948755393 1 617 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 596 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 2 3) Uncertain significance No change no 1 +Kanamycin rrs n.842A>T rrs_n.842A>T 1 non_coding_transcript_exon_variant 1472687 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1236 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 585 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 12 3) Uncertain significance No change no 1 +Kanamycin rrs n.845C>T rrs_n.845C>T 1 non_coding_transcript_exon_variant 1472690 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1131 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Kanamycin rrs n.847T>C rrs_n.847T>C 1 non_coding_transcript_exon_variant 1472692 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 3 3) Uncertain significance No change no 1 +Kanamycin rrs n.84C>T rrs_n.84C>T 1 non_coding_transcript_exon_variant 1471929 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.850C>T rrs_n.850C>T 1 non_coding_transcript_exon_variant 1472695 1 0 0 0 0 7 3546 20765 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1269 1879 False False 0 0 4.06480602430196 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1607 6349 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 615 992 False False 0 0 0 0 0 0 0 0 0 5.99028746746614 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 5 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.852T>C rrs_n.852T>C 1 non_coding_transcript_exon_variant 1472697 1 0 0 0 0 10 3546 20762 0 0 0.0010397522169524 0.99951858270749 0.999114835261082 0.999769118326375 0 0 0.30849710781876 NA NA NA 0 0 0.30849710781876 NA NA NA NA 1321 1879 False False 0 0 2.61340113759526 0 0 0.0010397522169524 0.99951858270749 0.999114835261082 0.999769118326375 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 7 1607 6346 0 0 0.0022928741555424 0.998898158350385 0.997731111129242 0.999556891392146 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 665 992 False False 0 0 0 0 0 0 0 0 0 2.74289259224573 0 0 0.0022928741555424 0.998898158350385 0.997731111129242 0.999556891392146 91 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.852T>G rrs_n.852T>G 1 non_coding_transcript_exon_variant 1472697 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1060 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 423 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.856T>A rrs_n.856T>A 1 non_coding_transcript_exon_variant 1472701 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1092 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.859C>T rrs_n.859C>T 1 non_coding_transcript_exon_variant 1472704 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.861C>T rrs_n.861C>T 1 non_coding_transcript_exon_variant 1472706 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 2 3) Uncertain significance No change no 1 +Kanamycin rrs n.868T>C rrs_n.868T>C 1 non_coding_transcript_exon_variant 1472713 0 0 0 0 4 19 3542 20753 0.00112803158488437 0.000307433460438748 0.00288566784728404 0.999085307144232 0.998571960712224 0.999449208150065 0.17391304347826 0.0495076453057934 0.387811889954797 NA NA NA 0 0 0.176466911806965 NA NA NA NA 1037 1879 False False 1.23349876667954 0.304969322398172 3.71425088040811 0 0 0.00104092580348739 0.999085307144232 0.998571960712224 0.999449208150065 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 14 1605 6339 0.00124455507156191 0.000150756945780856 0.00448845844972244 0.997796316700771 0.996305355363671 0.99879471848905 0.125 0.0155136038154138 0.383476236849263 NA NA NA 0 0 0.231635761650116 NA NA NA NA 402 992 False False 0 0 0 0 0 0 0 0.564218958611482 0.0621786020818812 2.4604690079564 0 0 0.0022957280374523 0.997796316700771 0.996305355363671 0.99879471848905 351 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.869A>G rrs_n.869A>G 1 non_coding_transcript_exon_variant 1472714 1 0 0 0 0 6 3546 20766 0 0 0.0010397522169524 0.999711149624494 0.999371401166804 0.999893989862555 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1257 1879 False False 0 0 4.9758630843129 0 0 0.0010397522169524 0.999711149624494 0.999371401166804 0.999893989862555 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 1607 6347 0 0 0.0022928741555424 0.99905556430033 0.997945503023207 0.999653332387469 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 605 992 False False 0 0 0 0 0 0 0 0 0 3.35786664322939 0 0 0.0022928741555424 0.99905556430033 0.997945503023207 0.999653332387469 124 3) Uncertain significance No change no 1 +Kanamycin rrs n.86G>A rrs_n.86G>A 1 non_coding_transcript_exon_variant 1471931 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1145 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.87_89delAGAinsGG rrs_n.87_89delAGAinsGG 1 non_coding_transcript_exon_variant 1471932 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1363 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 702 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.871C>T rrs_n.871C>T 1 non_coding_transcript_exon_variant 1472716 0 0 0 0 4 18 3542 20754 0.00112803158488437 0.000307433460438748 0.00288566784728404 0.999133448873483 0.998630820056588 0.999486348579758 0.181818181818181 0.0518672993124368 0.402845783077871 NA NA NA 0 0 0.185301968137852 NA NA NA NA 1223 1879 False False 1.30208921513269 0.320358127755557 3.95632359338967 0 0 0.00104092580348739 0.999133448873483 0.998630820056588 0.999486348579758 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 13 1605 6340 0.00124455507156191 0.000150756945780856 0.00448845844972244 0.997953722650716 0.996503345413809 0.998910007694291 0.133333333333333 0.0165759134400836 0.404602696603372 NA NA NA 0 0 0.24705263800047 NA NA NA NA 572 992 False False 0 0 0 0 0 0 0 0.607716271267673 0.0665186133153311 2.68867159282128 0 0 0.0022957280374523 0.997953722650716 0.996503345413809 0.998910007694291 341 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.876C>A rrs_n.876C>A 1 non_coding_transcript_exon_variant 1472721 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.878G>A rrs_n.878G>A 1 non_coding_transcript_exon_variant 1472723 1 22 0 22 12 23 3534 20749 0.00338409475465313 0.00174979607500839 0.00590386326830579 0.998892740227229 0.998339027077604 0.999297966870435 0.342857142857142 0.191324102188265 0.522109983393521 0 0 0.154372512815574 0 0 0.148185128915224 0 0 1.07244583049958 0.0630717879006154 37 1879 False False 3.06326123865062 1.38767418069965 6.42067533828324 0 0 0.00104328094242513 0.998892740227229 0.998339027077604 0.999297966870435 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 5 8 1602 6345 0.00311138767890479 0.00101100708660053 0.00724588638281331 0.99874075240044 0.997520296036287 0.99945619445686 0.384615384615384 0.13857933889016 0.684222397085936 0 0 0.369416647552819 0 0 0.369416647552819 0 0 2.32300644798599 0.371372116264899 56 992 False False 0 0 0 0 0 0 0 2.4754213483146 0.636182589008145 8.59374070112856 0 0 0.00230002220580469 0.99874075240044 0.997520296036287 0.99945619445686 54 3) Uncertain significance No change no 1 +Kanamycin rrs n.887G>A rrs_n.887G>A 1 non_coding_transcript_exon_variant 1472732 1 3 0 3 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 14.1782880202046 1 617 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.887G>T rrs_n.887G>T 1 non_coding_transcript_exon_variant 1472732 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.888G>A rrs_n.888G>A 1 non_coding_transcript_exon_variant 1472733 0 0 0 0 1 11 3545 20761 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.99947044097824 0.999052670645628 0.99973561734751 0.0833333333333333 0.00210759323186022 0.384796165150944 NA NA NA 0 0 0.284914152918154 NA NA NA NA 1163 1879 False False 0.532401589947429 0.0123687722233094 3.66537636152503 0 0 0.00104004536542481 0.99947044097824 0.999052670645628 0.99973561734751 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 8 1606 6345 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.99874075240044 0.997520296036287 0.99945619445686 0.111111111111111 0.00280913674659921 0.482496514917337 NA NA NA 0 0 0.369416647552819 NA NA NA NA 519 992 False False 0 0 0 0 0 0 0 0.493851183063511 0.0111262820523154 3.6883573216039 0 0 0.00229430020901157 0.99874075240044 0.997520296036287 0.99945619445686 346 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.889C>T rrs_n.889C>T 1 non_coding_transcript_exon_variant 1472734 0 0 0 0 2 13 3544 20759 0.000564015792442188 6.83122290578968e-05 0.00203591855262226 0.999374157519738 0.998930028080923 0.99966672449503 0.133333333333333 0.0165759134400836 0.404602696603372 NA NA NA 0 0 0.24705263800047 NA NA NA NA 1348 1879 False False 0.901154714360132 0.0986889742493136 3.98329702983899 0 0 0.0010403386792448 0.999374157519738 0.998930028080923 0.99966672449503 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 9 1607 6344 0 0 0.0022928741555424 0.998583346450495 0.997312461277908 0.999352017626566 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 689 992 False False 0 0 0 0 0 0 0 0 0 2.00246403812054 0 0 0.0022928741555424 0.998583346450495 0.997312461277908 0.999352017626566 53 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.891G>A rrs_n.891G>A 1 non_coding_transcript_exon_variant 1472736 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 14 3) Uncertain significance No change no 1 +Kanamycin rrs n.896G>A rrs_n.896G>A 1 non_coding_transcript_exon_variant 1472741 0 0 0 0 2 13 3544 20759 0.000564015792442188 6.83122290578968e-05 0.00203591855262226 0.999374157519738 0.998930028080923 0.99966672449503 0.133333333333333 0.0165759134400836 0.404602696603372 NA NA NA 0 0 0.24705263800047 NA NA NA NA 1173 1879 False False 0.901154714360132 0.0986889742493136 3.98329702983899 0 0 0.0010403386792448 0.999374157519738 0.998930028080923 0.99966672449503 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 9 1607 6344 0 0 0.0022928741555424 0.998583346450495 0.997312461277908 0.999352017626566 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 527 992 False False 0 0 0 0 0 0 0 0 0 2.00246403812054 0 0 0.0022928741555424 0.998583346450495 0.997312461277908 0.999352017626566 52 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.897C>T rrs_n.897C>T 1 non_coding_transcript_exon_variant 1472742 0 0 0 0 1 18 3545 20754 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999133448873483 0.998630820056588 0.999486348579758 0.0526315789473684 0.00133162880417942 0.260280654195214 NA NA NA 0 0 0.185301968137852 NA NA NA NA 1061 1879 False False 0.32524682651622 0.00780745855307623 2.06132383955558 0 0 0.00104004536542481 0.999133448873483 0.998630820056588 0.999486348579758 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 11 1606 6342 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.998268534550606 0.996904046831145 0.999135351755422 0.0833333333333333 0.00210759323186022 0.384796165150944 NA NA NA 0 0 0.284914152918154 NA NA NA NA 424 992 False False 0 0 0 0 0 0 0 0.358994679044492 0.00833869553663541 2.4734928655095 0 0 0.00229430020901157 0.998268534550606 0.996904046831145 0.999135351755422 391 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.899A>G rrs_n.899A>G 1 non_coding_transcript_exon_variant 1472744 0 0 0 0 4 26 3542 20746 0.00112803158488437 0.000307433460438748 0.00288566784728404 0.998748315039476 0.998166525570477 0.999182199990846 0.133333333333333 0.0375534963383633 0.307218350276126 NA NA NA 0 0 0.132274604497754 NA NA NA NA 1210 1879 False False 0.901098901098901 0.228402220808179 2.59944326392486 0 0 0.00104092580348739 0.998748315039476 0.998166525570477 0.999182199990846 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 18 1605 6335 0.00124455507156191 0.000150756945780856 0.00448845844972244 0.997166692900991 0.995525835694433 0.998319964918202 0.1 0.0123485271702948 0.316982714019082 NA NA NA 0 0 0.185301968137852 NA NA NA NA 560 992 False False 0 0 0 0 0 0 0 0.438560055382485 0.0493069886300576 1.83495754931445 0 0 0.0022957280374523 0.997166692900991 0.995525835694433 0.998319964918202 423 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.-89T>C rrs_n.-89T>C 1 upstream_gene_variant 1471757 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.905C>A rrs_n.905C>A 1 non_coding_transcript_exon_variant 1472750 1 8 0 8 2 8 3544 20764 0.000564015792442188 6.83122290578968e-05 0.00203591855262226 0.999614866165992 0.999241274614236 0.99983371235125 0.2 0.0252107263268333 0.556095462307641 0 0 0.369416647552819 0 0 0.369416647552819 0 0 3.4339890334302 0.612870865598637 153 1879 False False 1.46472911963882 0.151439261401278 7.34364495908934 0 0 0.0010403386792448 0.999614866165992 0.999241274614236 0.99983371235125 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Kanamycin rrs n.905C>G rrs_n.905C>G 1 non_coding_transcript_exon_variant 1472750 1 7 0 7 0 8 3546 20764 0 0 0.0010397522169524 0.999614866165992 0.999241274614236 0.99983371235125 0 0 0.369416647552819 0 0 0.409616397225003 0 0 0.369416647552819 0 0 4.06461026139319 0.603473084876286 149 1879 False False 0 0 3.43205141622579 0 0 0.0010397522169524 0.999614866165992 0.999241274614236 0.99983371235125 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 1607 6348 0 0 0.0022928741555424 0.999212970250275 0.99816429885228 0.999744405769873 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.31499754664604 0.590294849013717 75 992 False False 0 0 0 0 0 0 0 0 0 4.31499754664604 0 0 0.0022928741555424 0.999212970250275 0.99816429885228 0.999744405769873 7 3) Uncertain significance No change no 1 +Kanamycin rrs n.905C>T rrs_n.905C>T 1 non_coding_transcript_exon_variant 1472750 1 1 0 1 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 227.636869136849 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 425 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 3 3) Uncertain significance No change no 1 +Kanamycin rrs n.906A>G rrs_n.906A>G 1 non_coding_transcript_exon_variant 1472751 1 72 0 72 15 85 3531 20687 0.00423011844331641 0.0023694392623031 0.00696735420989913 0.995907953013672 0.994942570724916 0.996730149437907 0.15 0.0864543856416485 0.235307500148954 0 0 0.0499440837058546 0 0 0.0424703399112491 0 0 0.30820842940718 2.7144388179451e-05 15 1879 True True 1.03388475186166 0.553781974287385 1.80545046895287 0 0 0.00104416686942014 0.995907953013672 0.994942570724916 0.996730149437907 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 33 0 33 1 41 1606 6312 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.993546356052258 0.99125498580068 0.995364889567362 0.0238095238095238 0.000602623301603574 0.125658557174992 0 0 0.105762810074579 0 0 0.0860438362940284 0 0 0.465529540558162 0.000821949118744106 10 992 False True 0 1 1 0 0 0 0 0.0958600370561613 0.00237236571478836 0.565854941910995 0 0 0.00229430020901157 0.993546356052258 0.99125498580068 0.995364889567362 46 5) Not assoc w R UP from Uncertain to NotAwR yes 4 +Kanamycin rrs n.907_908dupAA rrs_n.907_908dupAA 1 non_coding_transcript_exon_variant 1472750 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.907A>C rrs_n.907A>C 1 non_coding_transcript_exon_variant 1472752 0 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1258 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Kanamycin rrs n.907A>T rrs_n.907A>T 1 non_coding_transcript_exon_variant 1472752 1 4 0 4 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 8.87534793394977 1 617 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.0580478247511 1 233 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 4 3) Uncertain significance No change no 1 +Kanamycin rrs n.908_909insT rrs_n.908_909insT 1 non_coding_transcript_exon_variant 1472753 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance No change no 1 +Kanamycin rrs n.908A>C rrs_n.908A>C 1 non_coding_transcript_exon_variant 1472753 1 22 2 20 4 22 3542 20750 0.00112803158488437 0.000307433460438748 0.00288566784728404 0.99894088195648 0.998396919060608 0.999336141078939 0.153846153846153 0.0435634765389238 0.348678785535361 0.0909090909090909 0.0112055860241509 0.291612741553933 0.0833333333333333 0.0102563412812501 0.269972801557603 0.585827216261998 0.0663608594065569 2.41335947802863 0.760868271777446 162 1879 False False 1.06514039320363 0.266665566261658 3.13864690813719 0.000564334085778781 6.83507841000175e-05 0.00203706664395484 0.99894088195648 0.998396919060608 0.999336141078939 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 9 1607 6344 0 0 0.0022928741555424 0.998583346450495 0.997312461277908 0.999352017626566 0 0 0.336267116879942 0 0 0.409616397225003 0 0 0.336267116879942 0 0 2.74202854306019 0.357343159907638 47 992 False False 0 0 0 0 0 0 0 0 0 2.00246403812054 0 0 0.0022928741555424 0.998583346450495 0.997312461277908 0.999352017626566 16 3) Uncertain significance No change no 1 +Kanamycin rrs n.908A>G rrs_n.908A>G 1 non_coding_transcript_exon_variant 1472753 1 3 0 3 1 3 3545 20769 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999855574812247 0.999577986903419 0.999970215063798 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 14.1822872771732 1 617 1879 False False 1.95289139633286 0.0371893922070044 24.3461286113284 0 0 0.00104004536542481 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 4 3) Uncertain significance No change no 1 +Kanamycin rrs n.908A>T rrs_n.908A>T 1 non_coding_transcript_exon_variant 1472753 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.909G>T rrs_n.909G>T 1 non_coding_transcript_exon_variant 1472754 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1237 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.910G>A rrs_n.910G>A 1 non_coding_transcript_exon_variant 1472755 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1270 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 616 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 20 3) Uncertain significance No change no 1 +Kanamycin rrs n.-91C>A rrs_n.-91C>A 1 upstream_gene_variant 1471755 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.-91C>T rrs_n.-91C>T 1 upstream_gene_variant 1471755 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1309 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 652 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 1 3) Uncertain significance No change no 1 +Kanamycin rrs n.922G>A rrs_n.922G>A 1 non_coding_transcript_exon_variant 1472767 1 0 0 0 0 11 3546 20761 0 0 0.0010397522169524 0.99947044097824 0.999052670645628 0.99973561734751 0 0 0.284914152918154 NA NA NA 0 0 0.284914152918154 NA NA NA NA 1249 1879 False False 0 0 2.33394419599086 0 0 0.0010397522169524 0.99947044097824 0.999052670645628 0.99973561734751 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 1607 6348 0 0 0.0022928741555424 0.999212970250275 0.99816429885228 0.999744405769873 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 597 992 False False 0 0 0 0 0 0 0 0 0 4.31499754664604 0 0 0.0022928741555424 0.999212970250275 0.99816429885228 0.999744405769873 76 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.924C>T rrs_n.924C>T 1 non_coding_transcript_exon_variant 1472769 0 0 0 0 2 0 3544 20772 0.000564015792442188 6.83122290578968e-05 0.00203591855262226 1 0.99982242673208 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1189 1879 False False Inf 1.10031452590981 Inf 0 0 0.0010403386792448 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 1605 6353 0.00124455507156191 0.000150756945780856 0.00448845844972244 1 0.999419516970794 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 542 992 False False 0 0 0 0 0 0 0 Inf 0.742689158362403 Inf 0 0 0.0022957280374523 1 0.999419516970794 1 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.929C>T rrs_n.929C>T 1 non_coding_transcript_exon_variant 1472774 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.-92T>G rrs_n.-92T>G 1 upstream_gene_variant 1471754 1 0 0 0 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1164 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Kanamycin rrs n.93_94insG rrs_n.93_94insG 1 non_coding_transcript_exon_variant 1471938 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.933C>G rrs_n.933C>G 1 non_coding_transcript_exon_variant 1472778 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1410 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 746 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.934G>A rrs_n.934G>A 1 non_coding_transcript_exon_variant 1472779 1 0 0 0 0 5 3546 20767 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1364 1879 False False 0 0 6.39361750002021 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 703 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 12 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.935G>A rrs_n.935G>A 1 non_coding_transcript_exon_variant 1472780 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Kanamycin rrs n.936C>T rrs_n.936C>T 1 non_coding_transcript_exon_variant 1472781 0 0 0 0 4 37 3542 20735 0.00112803158488437 0.000307433460438748 0.00288566784728404 0.998218756017716 0.997545617335941 0.998745539331288 0.0975609756097561 0.0272274667983608 0.231314549309461 NA NA NA 0 0 0.0948905874149899 NA NA NA NA 1284 1879 False False 0.632868893738459 0.163731543161644 1.76323040797624 0 0 0.00104092580348739 0.998218756017716 0.997545617335941 0.998745539331288 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 21 1605 6332 0.00124455507156191 0.000150756945780856 0.00448845844972244 0.996694475051156 0.994951569317597 0.997952699182993 0.0869565217391304 0.0107099660378758 0.280379335909411 NA NA NA 0 0 0.161097615219079 NA NA NA NA 630 992 False False 0 0 0 0 0 0 0 0.375730603767986 0.04267270108175 1.53989681633065 0 0 0.0022957280374523 0.996694475051156 0.994951569317597 0.997952699182993 508 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.-93C>T rrs_n.-93C>T 1 upstream_gene_variant 1471753 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1401 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Kanamycin rrs n.93dupT rrs_n.93dupT 1 non_coding_transcript_exon_variant 1471937 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.93T>A rrs_n.93T>A 1 non_coding_transcript_exon_variant 1471938 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1110 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 472 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.93T>G rrs_n.93T>G 1 non_coding_transcript_exon_variant 1471938 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.941C>T rrs_n.941C>T 1 non_coding_transcript_exon_variant 1472786 1 0 0 0 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1424 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 761 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 9 3) Uncertain significance No change no 1 +Kanamycin rrs n.945T>C rrs_n.945T>C 1 non_coding_transcript_exon_variant 1472790 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1377 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 716 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 91 3) Uncertain significance No change no 1 +Kanamycin rrs n.946G>C rrs_n.946G>C 1 non_coding_transcript_exon_variant 1472791 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.948A>C rrs_n.948A>C 1 non_coding_transcript_exon_variant 1472793 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1121 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 483 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.948A>T rrs_n.948A>T 1 non_coding_transcript_exon_variant 1472793 0 0 0 0 4 35 3542 20737 0.00112803158488437 0.000307433460438748 0.00288566784728404 0.998315039476218 0.997657399390305 0.998826091293338 0.102564102564102 0.0286601051260963 0.242209726950617 NA NA NA 0 0 0.100032435572105 NA NA NA NA 1132 1879 False False 0.669097362265064 0.172660528705094 1.87303057678233 0 0 0.00104092580348739 0.998315039476218 0.997657399390305 0.998826091293338 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 20 1605 6333 0.00124455507156191 0.000150756945780856 0.00448845844972244 0.996851881001102 0.995142152726785 0.99807601929298 0.0909090909090909 0.0112055860241509 0.291612741553933 NA NA NA 0 0 0.168433470983085 NA NA NA NA 491 992 False False 0 0 0 0 0 0 0 0.394579439252336 0.0446771247514957 1.62719083367394 0 0 0.0022957280374523 0.996851881001102 0.995142152726785 0.99807601929298 498 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.958T>A rrs_n.958T>A 1 non_coding_transcript_exon_variant 1472803 0 0 0 0 4 28 3542 20744 0.00112803158488437 0.000307433460438748 0.00288566784728404 0.998652031580974 0.998052395066333 0.999104103702576 0.125 0.0351306531033114 0.289948420190755 NA NA NA 0 0 0.123436118500263 NA NA NA NA 1190 1879 False False 0.836654029200613 0.213109820295992 2.39358864574031 0 0 0.00104092580348739 0.998652031580974 0.998052395066333 0.999104103702576 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 18 1605 6335 0.00124455507156191 0.000150756945780856 0.00448845844972244 0.997166692900991 0.995525835694433 0.998319964918202 0.1 0.0123485271702948 0.316982714019082 NA NA NA 0 0 0.185301968137852 NA NA NA NA 543 992 False False 0 0 0 0 0 0 0 0.438560055382485 0.0493069886300576 1.83495754931445 0 0 0.0022957280374523 0.997166692900991 0.995525835694433 0.998319964918202 471 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.958T>C rrs_n.958T>C 1 non_coding_transcript_exon_variant 1472803 1 0 0 0 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1146 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 503 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 3 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.970A>C rrs_n.970A>C 1 non_coding_transcript_exon_variant 1472815 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1111 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 473 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 2 3) Uncertain significance No change no 1 +Kanamycin rrs n.972C>T rrs_n.972C>T 1 non_coding_transcript_exon_variant 1472817 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.979T>A rrs_n.979T>A 1 non_coding_transcript_exon_variant 1472824 1 0 0 0 0 5 3546 20767 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1224 1879 False False 0 0 6.39361750002021 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 573 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 28 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.980G>A rrs_n.980G>A 1 non_coding_transcript_exon_variant 1472825 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1425 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 762 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 26 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.981G>A rrs_n.981G>A 1 non_coding_transcript_exon_variant 1472826 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1390 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.982G>T rrs_n.982G>T 1 non_coding_transcript_exon_variant 1472827 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1147 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 504 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.983T>C rrs_n.983T>C 1 non_coding_transcript_exon_variant 1472828 1 1 0 1 0 6 3546 20766 0 0 0.0010397522169524 0.999711149624494 0.999371401166804 0.999893989862555 0 0 0.4592581264399 0 0 0.975 0 0 0.4592581264399 0 0 227.593187588584 1 193 1879 False False 0 0 4.9758630843129 0 0 0.0010397522169524 0.999711149624494 0.999371401166804 0.999893989862555 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 492 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 40 3) Uncertain significance No change no 1 +Kanamycin rrs n.98T>C rrs_n.98T>C 1 non_coding_transcript_exon_variant 1471943 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1250 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 598 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.991_992delGCinsCCTTTG rrs_n.991_992delGCinsCCTTTG 1 non_coding_transcript_exon_variant 1472836 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1201 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.991_996delGCACAGinsCCTCT rrs_n.991_996delGCACAGinsCCTCT 1 non_coding_transcript_exon_variant 1472836 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1365 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 704 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.995A>C rrs_n.995A>C 1 non_coding_transcript_exon_variant 1472840 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1426 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 763 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.996_1002delGGACGCGinsAC rrs_n.996_1002delGGACGCGinsAC 1 non_coding_transcript_exon_variant 1472841 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1079 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.996_1003delGGACGCGTinsACC rrs_n.996_1003delGGACGCGTinsACC 1 non_coding_transcript_exon_variant 1472841 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1322 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.999C>A rrs_n.999C>A 1 non_coding_transcript_exon_variant 1472844 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1285 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 631 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin rrs n.9G>A rrs_n.9G>A 1 non_coding_transcript_exon_variant 1471854 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin rrs n.-9G>C rrs_n.-9G>C 1 upstream_gene_variant 1471837 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin Rv2477c c.1002C>T Rv2477c_c.1002C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.1030T>C Rv2477c_c.1030T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.1068C>T Rv2477c_c.1068C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 4 3545 20768 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999807433082996 0.99950702628237 0.999947529583666 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.46459802538787 0.0297312351170663 14.8120229375093 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.1071G>T Rv2477c_c.1071G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.1086A>G Rv2477c_c.1086A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 18 3546 20754 0 0 0.0010397522169524 0.999133448873483 0.998630820056588 0.999486348579758 0 0 0.185301968137852 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.33197531668918 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 17 1607 6336 0 0 0.0022928741555424 0.997324098850936 0.995719069008731 0.998440440224704 0 0 0.195064322969093 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.956776300287855 NA NA NA NA NA NA 18 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.1101C>T Rv2477c_c.1101C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.1104C>T Rv2477c_c.1104C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 3544 20772 0.000564015792442188 6.83122290578968e-05 0.00203591855262226 1 0.99982242673208 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.10031452590981 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.1116A>G Rv2477c_c.1116A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 17 3546 20755 0 0 0.0010397522169524 0.999181590602734 0.998689969592855 0.99952317637802 0 0 0.195064322969093 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.41921002298157 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 5 1607 6348 0 0 0.0022928741555424 0.999212970250275 0.99816429885228 0.999744405769873 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.31499754664604 NA NA NA NA NA NA 129 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.1122C>T Rv2477c_c.1122C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.1152C>A Rv2477c_c.1152C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.1152C>G Rv2477c_c.1152C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.1164C>T Rv2477c_c.1164C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 14.1782880202046 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.57085126512166 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.1176C>T Rv2477c_c.1176C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.1212G>A Rv2477c_c.1212G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 14.1782880202046 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.1221G>A Rv2477c_c.1221G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.2177754884198 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.1269G>A Rv2477c_c.1269G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.1275C>T Rv2477c_c.1275C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.-12C>A Rv2477c_c.-12C>A 2 upstream_gene_variant 2784054 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1862 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c c.1335C>T Rv2477c_c.1335C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.1383C>A Rv2477c_c.1383C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.1401C>T Rv2477c_c.1401C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.1413C>T Rv2477c_c.1413C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.1434G>C Rv2477c_c.1434G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.1443G>C Rv2477c_c.1443G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.1497C>T Rv2477c_c.1497C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.1512C>T Rv2477c_c.1512C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.2177754884198 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.1521G>T Rv2477c_c.1521G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.1542T>C Rv2477c_c.1542T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.1545C>T Rv2477c_c.1545C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 112 2198 3434 18574 0.0315848843767625 0.0260764528430844 0.0378821434498543 0.894184479106489 0.889922012193431 0.898336268504108 0.0484848484848484 0.0400870726049429 0.0580498986493764 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.275610326113165 0.225098953720127 0.334579682316418 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 27 428 1580 5925 0.0168014934660858 0.0111007360358014 0.0243517286158376 0.932630253423579 0.926186755156837 0.938673014667264 0.0593406593406593 0.0394663545076637 0.0851659776047495 NA NA NA NA NA NA NA NA NA NA NA NA False True 1 1 1 0 0 0 0 0.236565420560747 0.153477978639682 0.350771215628019 NA NA NA NA NA NA 3764 5) Not assoc w R Now listed Silent mutation no 0 +Kanamycin Rv2477c c.156C>G Rv2477c_c.156C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.1605C>T Rv2477c_c.1605C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 8 3546 20764 0 0 0.0010397522169524 0.999614866165992 0.999241274614236 0.99983371235125 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.43205141622579 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.1620C>T Rv2477c_c.1620C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.2177754884198 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.1638A>G Rv2477c_c.1638A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.1659C>T Rv2477c_c.1659C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.165C>T Rv2477c_c.165C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 3546 20767 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 6.39361750002021 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 5 1607 6348 0 0 0.0022928741555424 0.999212970250275 0.99816429885228 0.999744405769873 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.31499754664604 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.1663C>T Rv2477c_c.1663C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.1674C>T Rv2477c_c.1674C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.-20C>G Rv2477c_c.-20C>G 2 upstream_gene_variant 2784062 1 1 1 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.150201697158088 Inf 0.14581791265729 60 1879 False False Inf 0.150201697158088 Inf 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c c.-25A>C Rv2477c_c.-25A>C 2 upstream_gene_variant 2784067 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c c.270A>G Rv2477c_c.270A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.309C>T Rv2477c_c.309C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 14.1782880202046 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.312C>T Rv2477c_c.312C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.87534793394977 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.57085126512166 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.318C>T Rv2477c_c.318C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 11 3546 20761 0 0 0.0010397522169524 0.99947044097824 0.999052670645628 0.99973561734751 0 0 0.284914152918154 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.33394419599086 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 6 1607 6347 0 0 0.0022928741555424 0.99905556430033 0.997945503023207 0.999653332387469 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.35786664322939 NA NA NA NA NA NA 11 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.-31A>G Rv2477c_c.-31A>G 2 upstream_gene_variant 2784073 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c c.352C>T Rv2477c_c.352C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.387G>A Rv2477c_c.387G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.393C>T Rv2477c_c.393C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 6 3545 20766 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999711149624494 0.999371401166804 0.999893989862555 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.976304654442877 0.0212191705766405 8.05133152464184 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 4 1606 6349 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.99937037620022 0.998388704765699 0.99982842290899 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.98832503113325 0.0200561540991659 9.99322371223062 NA NA NA NA NA NA 20 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.396C>T Rv2477c_c.396C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.417G>A Rv2477c_c.417G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.-41T>C Rv2477c_c.-41T>C 2 upstream_gene_variant 2784083 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1866 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c c.429G>A Rv2477c_c.429G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.-44G>A Rv2477c_c.-44G>A 2 upstream_gene_variant 2784086 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c c.453G>A Rv2477c_c.453G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.45C>T Rv2477c_c.45C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.483C>T Rv2477c_c.483C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.2177754884198 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.0580478247511 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.489C>T Rv2477c_c.489C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.48C>T Rv2477c_c.48C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.492G>A Rv2477c_c.492G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.499C>A Rv2477c_c.499C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.-4C>T Rv2477c_c.-4C>T 2 upstream_gene_variant 2784046 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c c.51T>C Rv2477c_c.51T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 14.1782880202046 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.57085126512166 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.538C>T Rv2477c_c.538C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.541T>C Rv2477c_c.541T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 7 20 3539 20752 0.00197405527354765 0.000794029400507555 0.00406305244102797 0.999037165414981 0.998513369831025 0.9994117795557 0.259259259259259 0.111144562845442 0.462848742276171 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.05233116699632 0.732612162363018 5.05747515418276 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 4 1605 6349 0.00124455507156191 0.000150756945780856 0.00448845844972244 0.99937037620022 0.998388704765699 0.99982842290899 0.333333333333333 0.0432718682927417 0.777221904496487 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.97788161993769 0.178739259054919 13.8135366697626 NA NA NA NA NA NA 18 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.546G>A Rv2477c_c.546G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.558G>A Rv2477c_c.558G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.-55G>A Rv2477c_c.-55G>A 2 upstream_gene_variant 2784097 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c c.585G>A Rv2477c_c.585G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.612C>T Rv2477c_c.612C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.615C>T Rv2477c_c.615C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.618C>T Rv2477c_c.618C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 3546 20767 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 6.39361750002021 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 1607 6349 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 5.99028746746614 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.627C>T Rv2477c_c.627C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.639C>T Rv2477c_c.639C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.655C>T Rv2477c_c.655C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.69C>T Rv2477c_c.69C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.2177754884198 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.702C>A Rv2477c_c.702C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.708C>A Rv2477c_c.708C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.708C>T Rv2477c_c.708C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.2177754884198 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.723C>T Rv2477c_c.723C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 14.1782880202046 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.57085126512166 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.-72T>C Rv2477c_c.-72T>C 2 upstream_gene_variant 2784114 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1852 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 988 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c c.-73C>G Rv2477c_c.-73C>G 2 upstream_gene_variant 2784115 1 3 0 3 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 14.1776055911046 1 193 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 153.787547206498 1 233 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c c.753G>A Rv2477c_c.753G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.2177754884198 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.-75G>A Rv2477c_c.-75G>A 2 upstream_gene_variant 2784117 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c c.762G>A Rv2477c_c.762G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.-76C>G Rv2477c_c.-76C>G 2 upstream_gene_variant 2784118 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c c.-78delG Rv2477c_c.-78delG 2 upstream_gene_variant 2784119 NA 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1853 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c c.801C>T Rv2477c_c.801C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.2177754884198 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.-81G>A Rv2477c_c.-81G>A 2 upstream_gene_variant 2784123 1 9 0 9 0 10 3546 20762 0 0 0.0010397522169524 0.99951858270749 0.999114835261082 0.999769118326375 0 0 0.30849710781876 0 0 0.336267116879942 0 0 0.30849710781876 0 0 2.96772171506905 0.374006764233317 105.5 1879 False False 0 0 2.61340113759526 0 0 0.0010397522169524 0.99951858270749 0.999114835261082 0.999769118326375 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 19 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c c.81T>C Rv2477c_c.81T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.2177754884198 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.831C>T Rv2477c_c.831C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 3546 20767 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 6.39361750002021 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.0580478247511 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.846C>G Rv2477c_c.846C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.2177754884198 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.885A>C Rv2477c_c.885A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.894G>C Rv2477c_c.894G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.897G>A Rv2477c_c.897G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.-8A>G Rv2477c_c.-8A>G 2 upstream_gene_variant 2784050 1 8 0 8 0 11 3546 20761 0 0 0.0010397522169524 0.99947044097824 0.999052670645628 0.99973561734751 0 0 0.284914152918154 0 0 0.369416647552819 0 0 0.284914152918154 0 0 3.43155558322012 0.612916530541612 158.5 1879 False False 0 0 2.33394419599086 0 0 0.0010397522169524 0.99947044097824 0.999052670645628 0.99973561734751 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 21.0547398420152 1 233 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 25 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c c.909G>A Rv2477c_c.909G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.90G>A Rv2477c_c.90G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.918C>T Rv2477c_c.918C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.948C>G Rv2477c_c.948C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 49 3543 20723 0.000846023688663282 0.000174504417422474 0.00247043033885164 0.997641055266705 0.996882534958946 0.998254345736684 0.0576923076923076 0.0120593180267384 0.159473358638591 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.358101919853462 0.0713547327392864 1.11076418213424 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.0580478247511 NA NA NA NA NA NA 56 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.96C>T Rv2477c_c.96C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c c.9G>A Rv2477c_c.9G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 3546 20766 0 0 0.0010397522169524 0.999711149624494 0.999371401166804 0.999893989862555 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.9758630843129 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin Rv2477c LoF Rv2477c_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1879 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Ala134Val Rv2477c_p.Ala134Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Ala139Val Rv2477c_p.Ala139Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1859 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Ala260Arg Rv2477c_p.Ala260Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Ala260Val Rv2477c_p.Ala260Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Ala277Thr Rv2477c_p.Ala277Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1845 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Ala286Ser Rv2477c_p.Ala286Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1829 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 981 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Ala2Val Rv2477c_p.Ala2Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Ala335Thr Rv2477c_p.Ala335Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 14.1782880202046 1 617 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Ala392Thr Rv2477c_p.Ala392Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Ala392Val Rv2477c_p.Ala392Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1848 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Ala424Val Rv2477c_p.Ala424Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 8.87534793394977 1 617 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Ala428Thr Rv2477c_p.Ala428Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Ala454Val Rv2477c_p.Ala454Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1857 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 989 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Ala492Asp Rv2477c_p.Ala492Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1817 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Ala52Thr Rv2477c_p.Ala52Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1875 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Ala531Pro Rv2477c_p.Ala531Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Ala65Val Rv2477c_p.Ala65Val 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 2 3544 20770 0.000564015792442188 6.83122290578968e-05 0.00203591855262226 0.999903716541498 0.99965223478104 0.999988339413789 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1809 1879 False False 5.86060948081264 0.424646188620106 80.7055921553874 0 0 0.0010403386792448 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 2 1605 6351 0.00124455507156191 0.000150756945780856 0.00448845844972244 0.99968518810011 0.99886325869706 0.999961872544366 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 971 992 False False 0 0 0 0 0 0 0 3.95700934579439 0.286553713541028 54.5786958645469 0 0 0.0022957280374523 0.99968518810011 0.99886325869706 0.999961872544366 1 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Ala68Val Rv2477c_p.Ala68Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 8.87534793394977 1 617 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 1607 6349 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.99028746746614 0.589339945669686 68 992 False False 0 0 0 0 0 0 0 0 0 5.99028746746614 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 1 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Arg149Cys Rv2477c_p.Arg149Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1826 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Arg251Pro Rv2477c_p.Arg251Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1843 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 984 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Arg257Ser Rv2477c_p.Arg257Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Arg316His Rv2477c_p.Arg316His 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 31.2162477992404 1 193 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 992 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Arg316Ser Rv2477c_p.Arg316Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Arg346Cys Rv2477c_p.Arg346Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 19 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Arg450Lys Rv2477c_p.Arg450Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 3545 20771 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999951858270749 0.999731800967312 0.999998781157685 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 227.711777615967 1 617 1879 False False 5.8592383638928 0.0746220616644107 458.169367733398 0 0 0.00104004536542481 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Arg450Thr Rv2477c_p.Arg450Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1869 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Arg499Cys Rv2477c_p.Arg499Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1854 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Arg504Cys Rv2477c_p.Arg504Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 227.625948755393 1 617 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Arg553His Rv2477c_p.Arg553His 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Arg86His Rv2477c_p.Arg86His 2 missense_variant (see "Genomic_coordinates" sheet) 1 30 0 30 1 37 3545 20735 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.998218756017716 0.997545617335941 0.998745539331288 0.0263157894736842 0.000666036204202366 0.13809902979242 0 0 0.115703308222027 0 0 0.0948905874149899 0 0 0.765786153500301 0.0167004883608364 31 1879 False False 0.158083330156672 0.00390083638807375 0.937886994027838 0 0 0.00104004536542481 0.998218756017716 0.997545617335941 0.998745539331288 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 7 1607 6346 0 0 0.0022928741555424 0.998898158350385 0.997731111129242 0.999556891392146 0 0 0.409616397225003 0 0 0.707598226178713 0 0 0.409616397225003 0 0 9.56482572431895 1 233 992 False False 0 0 0 0 0 0 0 0 0 2.74289259224573 0 0 0.0022928741555424 0.998898158350385 0.997731111129242 0.999556891392146 57 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Asn80Lys Rv2477c_p.Asn80Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1863 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Asn88Ser Rv2477c_p.Asn88Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Asp133Tyr Rv2477c_p.Asp133Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Asp22Asn Rv2477c_p.Asp22Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Asp230Gly Rv2477c_p.Asp230Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Asp339Glu Rv2477c_p.Asp339Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 19 0 19 1 23 3545 20749 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.998892740227229 0.998339027077604 0.999297966870435 0.0416666666666666 0.00105435244546974 0.211201683456973 0 0 0.176466911806965 0 0 0.148185128915224 0 0 1.254914820145 0.0976051885153917 41 1879 False False 0.2544796713068 0.00617934309783882 1.56818036839517 0 0 0.00104004536542481 0.998892740227229 0.998339027077604 0.999297966870435 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 4 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Asp374Asn Rv2477c_p.Asp374Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.0580478247511 1 233 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 9 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Asp503Asn Rv2477c_p.Asp503Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Asp503Gly Rv2477c_p.Asp503Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1837 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Asp515His Rv2477c_p.Asp515His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Asp516Glu Rv2477c_p.Asp516Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1867 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Asp517Ala Rv2477c_p.Asp517Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 3 1 3543 20771 0.000846023688663282 0.000174504417422474 0.00247043033885164 0.999951858270749 0.999731800967312 0.999998781157685 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 1860 1879 False False 17.5876375952582 1.41144968084872 918.001314114865 0 0 0.00104063215855229 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 990 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Asp517Asn Rv2477c_p.Asp517Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1821 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Asp543Tyr Rv2477c_p.Asp543Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 227.636869136849 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Asp55Ala Rv2477c_p.Asp55Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 5 3546 20767 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1838 1879 False False 0 0 6.39361750002021 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Asp95Asn Rv2477c_p.Asp95Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Asp95Gly Rv2477c_p.Asp95Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Gln140Glu Rv2477c_p.Gln140Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Gln196His Rv2477c_p.Gln196His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 2 3544 20770 0.000564015792442188 6.83122290578968e-05 0.00203591855262226 0.999903716541498 0.99965223478104 0.999988339413789 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1861 1879 False False 5.86060948081264 0.424646188620106 80.7055921553874 0 0 0.0010403386792448 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Gln417His Rv2477c_p.Gln417His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Gln74His Rv2477c_p.Gln74His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Glu105Lys Rv2477c_p.Glu105Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Glu117Ala Rv2477c_p.Glu117Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1873 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Glu120Asp Rv2477c_p.Glu120Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1814 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Glu127Asp Rv2477c_p.Glu127Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Glu128Asp Rv2477c_p.Glu128Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Glu224Lys Rv2477c_p.Glu224Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1822 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 975 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Glu238Val Rv2477c_p.Glu238Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 227.636869136849 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Glu268Lys Rv2477c_p.Glu268Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Glu308Lys Rv2477c_p.Glu308Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Glu476Ala Rv2477c_p.Glu476Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.0580478247511 1 233 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Glu538_Leu540delinsVal Rv2477c_p.Glu538_Leu540delinsVal 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1840 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Glu81Lys Rv2477c_p.Glu81Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Glu90Asp Rv2477c_p.Glu90Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Glu91Asp Rv2477c_p.Glu91Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1811 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 972 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Glu91Gly Rv2477c_p.Glu91Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Gly123Asp Rv2477c_p.Gly123Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 227.636869136849 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Gly162Ser Rv2477c_p.Gly162Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1830 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Gly207Asp Rv2477c_p.Gly207Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Gly207Ser Rv2477c_p.Gly207Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Gly256Ser Rv2477c_p.Gly256Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Gly314Arg Rv2477c_p.Gly314Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1874 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Gly409Ser Rv2477c_p.Gly409Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 3545 20771 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999951858270749 0.999731800967312 0.999998781157685 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1864 1879 False False 5.8592383638928 0.0746220616644107 458.169367733398 0 0 0.00104004536542481 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 1606 6352 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.999842594050055 0.999123305664052 0.999996014834324 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 991 992 False False 0 0 0 0 0 0 0 3.95516811955168 0.0503551805307198 309.72516523151 0 0 0.00229430020901157 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Gly41Glu Rv2477c_p.Gly41Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 302 24 278 33 300 3513 20472 0.0093062605752961 0.00641441556315769 0.013044834813662 0.985557481224725 0.983841246735971 0.987135771643398 0.0990990990990991 0.0692013545986522 0.136353036388702 0.0794701986754966 0.0515801900053947 0.115938577131217 0.074074074074074 0.0480347256892533 0.108213100760581 0.503093340869575 0.316459994025173 0.765675610929671 0.000542240802605815 18 1879 False False 0.641024765157984 0.432451767761066 0.92197568007299 0.00678541136556403 0.00435223757451736 0.0100794330259739 0.985557481224725 0.983841246735971 0.987135771643398 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 14 2 12 4 13 1603 6340 0.00248911014312383 0.000678602218007884 0.00636074311848652 0.997953722650716 0.996503345413809 0.998910007694291 0.235294117647058 0.0681077404373566 0.49899327320458 0.142857142857142 0.0177945154831915 0.428129160909698 0.133333333333333 0.0165759134400836 0.404602696603372 0.659180702848825 0.0715866202748079 2.96556900745427 0.749131698225107 84 992 False False 0 0 0 0 0 0 0 1.21694898987475 0.288662509529051 3.94619645336276 0.00124610591900311 0.000150944849281046 0.00449404244088155 0.997953722650716 0.996503345413809 0.998910007694291 55 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Gly433Val Rv2477c_p.Gly433Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Gly441Ala Rv2477c_p.Gly441Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 10 0 10 0 13 3546 20759 0 0 0.0010397522169524 0.999374157519738 0.998930028080923 0.99966672449503 0 0 0.24705263800047 0 0 0.30849710781876 0 0 0.24705263800047 0 0 2.61302358294071 0.375741076450505 111 1879 False False 0 0 1.92188449077932 0 0 0.0010397522169524 0.999374157519738 0.998930028080923 0.99966672449503 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 0 11 1607 6342 0 0 0.0022928741555424 0.998268534550606 0.996904046831145 0.999135351755422 0 0 0.284914152918154 0 0 0.30849710781876 0 0 0.284914152918154 0 0 1.76275709190229 0.228817619155773 45 992 False False 0 0 0 0 0 0 0 0 0 1.57440756412985 0 0 0.0022928741555424 0.998268534550606 0.996904046831145 0.999135351755422 22 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Gly530Asp Rv2477c_p.Gly530Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Gly558Asp Rv2477c_p.Gly558Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1871 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Gly87Arg Rv2477c_p.Gly87Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Gly87Ser Rv2477c_p.Gly87Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1855 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.His189Tyr Rv2477c_p.His189Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 5 8 3541 20764 0.00141003948110547 0.000457989490992675 0.00328746875206548 0.999614866165992 0.999241274614236 0.99983371235125 0.384615384615384 0.13857933889016 0.684222397085936 0 0 0.521823750104981 0 0 0.369416647552819 0 0 6.40172379115845 1 617 1879 False False 3.6649251623835 0.942710278412932 12.7134411919674 0 0 0.00104121961419034 0.999614866165992 0.999241274614236 0.99983371235125 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 4 1604 6349 0.00186683260734287 0.000385151348909821 0.00544589495836224 0.99937037620022 0.998388704765699 0.99982842290899 0.428571428571428 0.0989882784425078 0.815948432359917 0 0 0.975 0 0 0.602364635616474 0 0 154.026091959337 1 233 992 False False 0 0 0 0 0 0 0 2.96867206982543 0.434359218125022 17.5617612770521 0 0 0.00229715764418053 0.99937037620022 0.998388704765699 0.99982842290899 14 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.His201Asp Rv2477c_p.His201Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1868 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.His326Arg Rv2477c_p.His326Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1876 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.His548Arg Rv2477c_p.His548Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Ile20Val Rv2477c_p.Ile20Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1828 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 980 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Ile396Val Rv2477c_p.Ile396Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Ile464Val Rv2477c_p.Ile464Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Leu109Phe Rv2477c_p.Leu109Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1877 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Leu148Pro Rv2477c_p.Leu148Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1831 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Leu198Val Rv2477c_p.Leu198Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Leu227Gln Rv2477c_p.Leu227Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 3546 20767 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 6.39361750002021 1 617 1879 False False 0 0 6.39361750002021 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 1607 6348 0 0 0.0022928741555424 0.999212970250275 0.99816429885228 0.999744405769873 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.31499754664604 0.590294849013717 75 992 False False 0 0 0 0 0 0 0 0 0 4.31499754664604 0 0 0.0022928741555424 0.999212970250275 0.99816429885228 0.999744405769873 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Leu288Val Rv2477c_p.Leu288Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 18 1 17 3 18 3543 20754 0.000846023688663282 0.000174504417422474 0.00247043033885164 0.999133448873483 0.998630820056588 0.999486348579758 0.142857142857142 0.0304889676215155 0.363423987016981 0.0555555555555555 0.00140555616736942 0.272943599673368 0.0526315789473684 0.00133162880417942 0.260280654195214 0.344573392439109 0.00824595822601722 2.20048738602207 0.500627499030686 127 1879 False False 0.976291278577476 0.184114243497144 3.34673339683267 0.00028216704288939 7.1438254941256e-06 0.00157112051380901 0.999133448873483 0.998630820056588 0.999486348579758 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 0 9 1607 6344 0 0 0.0022928741555424 0.998583346450495 0.997312461277908 0.999352017626566 0 0 0.336267116879942 0 0 0.369416647552819 0 0 0.336267116879942 0 0 2.31540806496295 0.371668939016413 57 992 False False 0 0 0 0 0 0 0 0 0 2.00246403812054 0 0 0.0022928741555424 0.998583346450495 0.997312461277908 0.999352017626566 21 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Leu327His Rv2477c_p.Leu327His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Leu327Phe Rv2477c_p.Leu327Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 1 5 3545 20767 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999759291353745 0.999438356476751 0.999921838086342 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.521823750104981 0 0 0.521823750104981 0 0 6.39542169747642 1 617 1879 False False 1.17162200282087 0.0247643691956443 10.4748703386698 0 0 0.00104004536542481 0.999759291353745 0.999438356476751 0.999921838086342 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Leu370Arg Rv2477c_p.Leu370Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Leu455Ser Rv2477c_p.Leu455Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.150201697158088 Inf 0.14581791265729 60 1879 False False Inf 0.150201697158088 Inf 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.101367337197729 Inf 0.201884422110552 36.5 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Leu473Arg Rv2477c_p.Leu473Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1833 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Leu481Val Rv2477c_p.Leu481Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Leu486Arg Rv2477c_p.Leu486Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1858 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Leu540Phe Rv2477c_p.Leu540Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 8.87534793394977 1 617 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Leu73Pro Rv2477c_p.Leu73Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.150201697158088 Inf 0.14581791265729 60 1879 False False Inf 0.150201697158088 Inf 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Lys278Asn Rv2477c_p.Lys278Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Lys303Glu Rv2477c_p.Lys303Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1856 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Lys33Asn Rv2477c_p.Lys33Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 9 3546 20763 0 0 0.0010397522169524 0.999566724436741 0.999177668076772 0.99980186029375 0 0 0.336267116879942 0 0 0.409616397225003 0 0 0.336267116879942 0 0 4.06441449849838 0.603473481447955 151 1879 False False 0 0 2.96786458045639 0 0 0.0010397522169524 0.999566724436741 0.999177668076772 0.99980186029375 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 5 1607 6348 0 0 0.0022928741555424 0.999212970250275 0.99816429885228 0.999744405769873 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 5.98934515674784 0.589327498586392 65 992 False False 0 0 0 0 0 0 0 0 0 4.31499754664604 0 0 0.0022928741555424 0.999212970250275 0.99816429885228 0.999744405769873 1 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Lys379Asn Rv2477c_p.Lys379Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 3 3545 20769 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999855574812247 0.999577986903419 0.999970215063798 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1849 1879 False False 1.95289139633286 0.0371893922070044 24.3461286113284 0 0 0.00104004536542481 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Lys385Thr Rv2477c_p.Lys385Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1850 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Lys458Asn Rv2477c_p.Lys458Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1812 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 973 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Lys458Glu Rv2477c_p.Lys458Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Met93Ile Rv2477c_p.Met93Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 2 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Phe306Ser Rv2477c_p.Phe306Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Phe429Leu Rv2477c_p.Phe429Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Phe488Leu Rv2477c_p.Phe488Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Phe4Ser Rv2477c_p.Phe4Ser 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 2 3545 20770 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999903716541498 0.99965223478104 0.999988339413789 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1851 1879 False False 2.92947813822284 0.0496406430315194 56.2247306595764 0 0 0.00104004536542481 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Pro186Leu Rv2477c_p.Pro186Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1832 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Pro186Ser Rv2477c_p.Pro186Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1841 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Pro236His Rv2477c_p.Pro236His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 227.636869136849 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Pro312Gln Rv2477c_p.Pro312Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1818 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Pro355Ser Rv2477c_p.Pro355Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1807 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Pro39Ser Rv2477c_p.Pro39Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 16 0 16 0 16 3546 20756 0 0 0.0010397522169524 0.999229732331985 0.998749434152838 0.999559663409708 0 0 0.205907214207822 0 0 0.205907214207822 0 0 0.205907214207822 0 0 1.51862445866705 0.151719879251819 78.5 1879 False False 0 0 1.51862445866705 0 0 0.0010397522169524 0.999229732331985 0.998749434152838 0.999559663409708 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 15 0 15 0 15 1607 6338 0 0 0.0022928741555424 0.997638910750826 0.996108727739866 0.998677932833021 0 0 0.218019360910534 0 0 0.218019360910534 0 0 0.218019360910534 0 0 1.10108282293089 0.052735698423258 24.5 992 False False 0 0 0 0 0 0 0 0 0 1.10108282293089 0 0 0.0022928741555424 0.997638910750826 0.996108727739866 0.998677932833021 7 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Pro421Leu Rv2477c_p.Pro421Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Pro434Gln Rv2477c_p.Pro434Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1842 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 983 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 6 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Pro489Leu Rv2477c_p.Pro489Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1846 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Pro489Ser Rv2477c_p.Pro489Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.0580478247511 1 233 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Pro547Leu Rv2477c_p.Pro547Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1813 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Pro78Ala Rv2477c_p.Pro78Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Pro78Ser Rv2477c_p.Pro78Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Ser176Ala Rv2477c_p.Ser176Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1810 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Ser176Pro Rv2477c_p.Ser176Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1834 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Ser242Pro Rv2477c_p.Ser242Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Ser27Gly Rv2477c_p.Ser27Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 7 3546 20765 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 4.06480602430196 0.603472689124846 144 1879 False False 0 0 4.06480602430196 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Ser341Ala Rv2477c_p.Ser341Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Ser341Trp Rv2477c_p.Ser341Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 2 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Ser375Gly Rv2477c_p.Ser375Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1808 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 970 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Ser377Cys Rv2477c_p.Ser377Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1835 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Ser407Ala Rv2477c_p.Ser407Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1878 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Ser480Leu Rv2477c_p.Ser480Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Ter559Glnext*? Rv2477c_p.Ter559Glnext*? 2 stop_lost (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1819 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Thr187Ala Rv2477c_p.Thr187Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1836 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Thr267Ile Rv2477c_p.Thr267Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1823 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 976 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Thr372Lys Rv2477c_p.Thr372Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 0 11 3546 20761 0 0 0.0010397522169524 0.99947044097824 0.999052670645628 0.99973561734751 0 0 0.284914152918154 0 0 0.369416647552819 0 0 0.284914152918154 0 0 3.43155558322012 0.612916530541612 158.5 1879 False False 0 0 2.33394419599086 0 0 0.0010397522169524 0.99947044097824 0.999052670645628 0.99973561734751 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 21.0547398420152 1 233 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 71 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Thr505Arg Rv2477c_p.Thr505Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1824 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 977 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Thr505Met Rv2477c_p.Thr505Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Thr551Ile Rv2477c_p.Thr551Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Thr7Met Rv2477c_p.Thr7Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 14.1782880202046 1 617 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Trp524Arg Rv2477c_p.Trp524Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1820 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Tyr114Asp Rv2477c_p.Tyr114Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1815 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 974 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Tyr114Cys Rv2477c_p.Tyr114Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Val168Ala Rv2477c_p.Val168Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1844 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 985 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Val313Leu Rv2477c_p.Val313Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Val313Phe Rv2477c_p.Val313Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 1 3544 20771 0.000564015792442188 6.83122290578968e-05 0.00203591855262226 0.999951858270749 0.999731800967312 0.999998781157685 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 1816 1879 False False 11.721783295711 0.609968155150262 688.286392190459 0 0 0.0010403386792448 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Val320Met Rv2477c_p.Val320Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 6 3546 20766 0 0 0.0010397522169524 0.999711149624494 0.999371401166804 0.999893989862555 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1827 1879 False False 0 0 4.9758630843129 0 0 0.0010397522169524 0.999711149624494 0.999371401166804 0.999893989862555 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 979 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 3 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Val322Ile Rv2477c_p.Val322Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1825 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 978 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Val324Ala Rv2477c_p.Val324Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Val368Phe Rv2477c_p.Val368Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 3545 20771 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999951858270749 0.999731800967312 0.999998781157685 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 227.711777615967 1 617 1879 False False 5.8592383638928 0.0746220616644107 458.169367733398 0 0 0.00104004536542481 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 986 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 6 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Val384Leu Rv2477c_p.Val384Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Val389_Asp390insGly Rv2477c_p.Val389_Asp390insGly 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1847 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 987 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Val389Ala Rv2477c_p.Val389Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Val405Gly Rv2477c_p.Val405Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 6 3546 20766 0 0 0.0010397522169524 0.999711149624494 0.999371401166804 0.999893989862555 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1865 1879 False False 0 0 4.9758630843129 0 0 0.0010397522169524 0.999711149624494 0.999371401166804 0.999893989862555 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Val406Phe Rv2477c_p.Val406Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Val420Ala Rv2477c_p.Val420Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Val426Ala Rv2477c_p.Val426Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1839 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 982 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 3 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Val426Met Rv2477c_p.Val426Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 8 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Val475Gly Rv2477c_p.Val475Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Val493Met Rv2477c_p.Val493Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 227.636869136849 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Val550fs Rv2477c_p.Val550fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1872 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Val70Ala Rv2477c_p.Val70Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 227.625948755393 1 617 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Val70Met Rv2477c_p.Val70Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Val85Ile Rv2477c_p.Val85Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 30 1 29 11 35 3535 20737 0.00310208685843203 0.0015495363119703 0.00554369603206677 0.998315039476218 0.997657399390305 0.998826091293338 0.239130434782608 0.125861394822569 0.387668910114071 0.0333333333333333 0.000843570926630479 0.172169455633412 0.0277777777777777 0.00070302520590478 0.145289264746853 0.202282592791298 0.00495484658051417 1.2208967990445 0.114564424086112 44 1879 False False 1.8436613457264 0.843819060260506 3.71786729623036 0.000282805429864253 7.15998793738174e-06 0.00157467278749928 0.998315039476218 0.997657399390305 0.998826091293338 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.57085126512166 1 233 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 91 3) Uncertain significance New Uncertain no 0 +Kanamycin Rv2477c p.Val89Met Rv2477c_p.Val89Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1870 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-100G>A whiB6_c.-100G>A 2 upstream_gene_variant 4338621 1 0 0 0 0 5 3546 20767 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1534 1879 False False 0 0 6.39361750002021 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 834 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 6 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-101T>C whiB6_c.-101T>C 2 upstream_gene_variant 4338622 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-103C>G whiB6_c.-103C>G 2 upstream_gene_variant 4338624 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1621 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 890 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-103C>T whiB6_c.-103C>T 2 upstream_gene_variant 4338624 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 4 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-104C>T whiB6_c.-104C>T 2 upstream_gene_variant 4338625 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-109C>A whiB6_c.-109C>A 2 upstream_gene_variant 4338630 1 11 1 10 1 15 3545 20757 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999277874061236 0.998809242329947 0.999595777053137 0.0625 0.00158111172276588 0.302320738434531 0.0909090909090909 0.00229897221381426 0.412779916988382 0.0625 0.00158111172276588 0.302320738434531 0.585528913963328 0.0134916136598086 4.11823402936045 1 193 1879 False False 0.390352609308885 0.00927318459084571 2.5386679171915 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999277874061236 0.998809242329947 0.999595777053137 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 7 1607 6346 0 0 0.0022928741555424 0.998898158350385 0.997731111129242 0.999556891392146 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 3.35733699717867 0.607623167394402 83 992 False False 0 0 0 0 0 0 0 0 0 2.74289259224573 0 0 0.0022928741555424 0.998898158350385 0.997731111129242 0.999556891392146 23 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-10G>A whiB6_c.-10G>A 2 upstream_gene_variant 4338531 1 3 0 3 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 14.1782880202046 1 617 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-110T>C whiB6_c.-110T>C 2 upstream_gene_variant 4338631 1 1 0 1 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 227.636869136849 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-110T>G whiB6_c.-110T>G 2 upstream_gene_variant 4338631 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1647 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 906 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 2 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-112_-111insTTAACAGG whiB6_c.-112_-111insTTAACAGG 2 upstream_gene_variant 4338632 1 1 0 1 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 227.625948755393 1 617 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-113G>C whiB6_c.-113G>C 2 upstream_gene_variant 4338634 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-113G>T whiB6_c.-113G>T 2 upstream_gene_variant 4338634 NA 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1571 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 858 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-114A>C whiB6_c.-114A>C 2 upstream_gene_variant 4338635 1 33 1 32 4 40 3542 20732 0.00112803158488437 0.000307433460438748 0.00288566784728404 0.998074330829963 0.997378698599023 0.998623928311741 0.0909090909090909 0.0253284217034507 0.216686589465274 0.0303030303030303 0.000766912075048109 0.157593972272496 0.024390243902439 0.000617316893286519 0.128554020384146 0.182912196499153 0.00449462646760775 1.09574086829023 0.0786687268743558 39 1879 False False 0.585319028797289 0.152008074237248 1.620662135857 0.000282246683601467 7.14584180797538e-06 0.00157156367129611 0.998074330829963 0.997378698599023 0.998623928311741 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 12 1 11 4 13 1603 6340 0.00248911014312383 0.000678602218007884 0.00636074311848652 0.997953722650716 0.996503345413809 0.998910007694291 0.235294117647058 0.0681077404373566 0.49899327320458 0.0833333333333333 0.00210759323186022 0.384796165150944 0.0714285714285714 0.00180678065912538 0.338684489931821 0.359553110644813 0.00835165060515552 2.47734359692215 0.479719064606407 59 992 False False 0 0 0 0 0 0 0 1.21694898987475 0.288662509529051 3.94619645336276 0.000623441396508728 1.57840449969164e-05 0.00346864704418197 0.997953722650716 0.996503345413809 0.998910007694291 66 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-114A>G whiB6_c.-114A>G 2 upstream_gene_variant 4338635 1 4 0 4 1 5 3545 20767 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999759291353745 0.999438356476751 0.999921838086342 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.602364635616474 0 0 0.521823750104981 0 0 8.87742477646947 1 617 1879 False False 1.17162200282087 0.0247643691956443 10.4748703386698 0 0 0.00104004536542481 0.999759291353745 0.999438356476751 0.999921838086342 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 3 1606 6350 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.999527782150165 0.998620605323549 0.999902606737868 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.57681161401019 1 233 992 False False 0 0 0 0 0 0 0 1.31797426317974 0.0250900413291082 16.4244635399174 0 0 0.00229430020901157 0.999527782150165 0.998620605323549 0.999902606737868 2 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-114A>T whiB6_c.-114A>T 2 upstream_gene_variant 4338635 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-115_-114insT whiB6_c.-115_-114insT 2 upstream_gene_variant 4338635 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-115_-23delCAGGATCTATGCCCTGGTACTCGGCGGTGCGCGCACTAGAGCTCGGAGCTCGCCGAACCGGAGCCGCAGCACCGCTAGGCAGGCAGAGGAGGA whiB6_c.-115_-23delCAGGATCTATGCCCTGGTACTCGGCGGTGCGCGCACTAGAGCTCGGAGCTCGCCGAACCGGAGCCGCAGCACCGCTAGGCAGGCAGAGGAGGA 2 upstream_gene_variant 4338543 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1559 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 852 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-115C>A whiB6_c.-115C>A 2 upstream_gene_variant 4338636 1 2 0 2 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 31.2162477992404 1 193 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.0580478247511 1 233 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-116A>C whiB6_c.-116A>C 2 upstream_gene_variant 4338637 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1587 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 867 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 12 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-117A>G whiB6_c.-117A>G 2 upstream_gene_variant 4338638 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1607 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 880 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-119T>G whiB6_c.-119T>G 2 upstream_gene_variant 4338640 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-11C>G whiB6_c.-11C>G 2 upstream_gene_variant 4338532 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1583 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-122_-104delTGATTAACAGGATCTATGC whiB6_c.-122_-104delTGATTAACAGGATCTATGC 2 upstream_gene_variant 4338624 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-122T>C whiB6_c.-122T>C 2 upstream_gene_variant 4338643 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-123_-34delCTGATTAACAGGATCTATGCCCTGGTACTCGGCGGTGCGCGCACTAGAGCTCGGAGCTCGCCGAACCGGAGCCGCAGCACCGCTAGGCAG whiB6_c.-123_-34delCTGATTAACAGGATCTATGCCCTGGTACTCGGCGGTGCGCGCACTAGAGCTCGGAGCTCGCCGAACCGGAGCCGCAGCACCGCTAGGCAG 2 upstream_gene_variant 4338554 NA 0 0 0 2 0 3544 20772 0.000564015792442188 6.83122290578968e-05 0.00203591855262226 1 0.99982242673208 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1527 1879 False False Inf 1.10031452590981 Inf 0 0 0.0010403386792448 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-125_-124insA whiB6_c.-125_-124insA 2 upstream_gene_variant 4338645 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-125A>C whiB6_c.-125A>C 2 upstream_gene_variant 4338646 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1539 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-125A>G whiB6_c.-125A>G 2 upstream_gene_variant 4338646 1 7 0 7 1 10 3545 20762 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.99951858270749 0.999114835261082 0.999769118326375 0.0909090909090909 0.00229897221381426 0.412779916988382 0 0 0.409616397225003 0 0 0.30849710781876 0 0 4.06536578075695 0.603471546500309 140 1879 False False 0.585669957686882 0.0134948626376594 4.11922590459154 0 0 0.00104004536542481 0.99951858270749 0.999114835261082 0.999769118326375 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 1606 6351 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.99968518810011 0.99886325869706 0.999961872544366 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 153.883075087497 1 233 992 False False 0 0 0 0 0 0 0 1.97727272727272 0.0334940093351611 38.0316888278718 0 0 0.00229430020901157 0.99968518810011 0.99886325869706 0.999961872544366 4 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-126C>A whiB6_c.-126C>A 2 upstream_gene_variant 4338647 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-126C>G whiB6_c.-126C>G 2 upstream_gene_variant 4338647 1 2 0 2 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 31.2162477992404 1 193 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-126C>T whiB6_c.-126C>T 2 upstream_gene_variant 4338647 1 4 0 4 1 4 3545 20768 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999807433082996 0.99950702628237 0.999947529583666 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 8.87785221853298 1 617 1879 False False 1.46459802538787 0.0297312351170663 14.8120229375093 0 0 0.00104004536542481 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 4 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.12T>C whiB6_c.12T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin whiB6 c.-12T>C whiB6_c.-12T>C 2 upstream_gene_variant 4338533 1 4 0 4 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 8.87534793394977 1 617 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.138C>T whiB6_c.138C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.2177754884198 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.0580478247511 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin whiB6 c.-13A>G whiB6_c.-13A>G 2 upstream_gene_variant 4338534 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-14C>T whiB6_c.-14C>T 2 upstream_gene_variant 4338535 1 6 0 6 0 9 3546 20763 0 0 0.0010397522169524 0.999566724436741 0.999177668076772 0.99980186029375 0 0 0.336267116879942 0 0 0.4592581264399 0 0 0.336267116879942 0 0 4.97514428344383 0.602093452433667 130 1879 False False 0 0 2.96786458045639 0 0 0.0010397522169524 0.999566724436741 0.999177668076772 0.99980186029375 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 910 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 22 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.150G>A whiB6_c.150G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 14.1782880202046 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin whiB6 c.159C>T whiB6_c.159C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin whiB6 c.-15G>T whiB6_c.-15G>T 2 upstream_gene_variant 4338536 NA 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1674 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-16T>C whiB6_c.-16T>C 2 upstream_gene_variant 4338537 1 1 0 1 0 18 3546 20754 0 0 0.0010397522169524 0.999133448873483 0.998630820056588 0.999486348579758 0 0 0.185301968137852 0 0 0.975 0 0 0.185301968137852 0 0 227.462142584748 1 617 1879 False False 0 0 1.33197531668918 0 0 0.0010397522169524 0.999133448873483 0.998630820056588 0.999486348579758 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 861 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 26 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.171G>A whiB6_c.171G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.2177754884198 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin whiB6 c.174C>T whiB6_c.174C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin whiB6 c.-17T>C whiB6_c.-17T>C 2 upstream_gene_variant 4338538 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-182_-115delTTTTCCTGGAAGATCTGCCCGAAGGGGTCGGATACGCGCCGGCGAGGCCAGATACACAGCTGATTAAC whiB6_c.-182_-115delTTTTCCTGGAAGATCTGCCCGAAGGGGTCGGATACGCGCCGGCGAGGCCAGATACACAGCTGATTAAC 2 upstream_gene_variant 4338635 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1599 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-183_-34del whiB6_c.-183_-34del 2 upstream_gene_variant 4338554 NA 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1635 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-184_-44del whiB6_c.-184_-44del 2 upstream_gene_variant 4338564 1 4 0 4 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 8.87534793394977 1 617 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-186_-29del whiB6_c.-186_-29del 2 upstream_gene_variant 4338549 1 2 0 2 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 31.2162477992404 1 193 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-186_-69del whiB6_c.-186_-69del 2 upstream_gene_variant 4338589 1 3 0 3 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 14.1782880202046 1 617 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-187_-31del whiB6_c.-187_-31del 2 upstream_gene_variant 4338551 NA 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1608 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.18G>A whiB6_c.18G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 3545 20771 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999951858270749 0.999731800967312 0.999998781157685 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 5.8592383638928 0.0746220616644107 458.169367733398 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin whiB6 c.-190_-40del whiB6_c.-190_-40del 2 upstream_gene_variant 4338560 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1555 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-192_-110delGTCAGAACACTTTTCCTGGAAGATCTGCCCGAAGGGGTCGGATACGCGCCGGCGAGGCCAGATACACAGCTGATTAACAGGAT whiB6_c.-192_-110delGTCAGAACACTTTTCCTGGAAGATCTGCCCGAAGGGGTCGGATACGCGCCGGCGAGGCCAGATACACAGCTGATTAACAGGAT 2 upstream_gene_variant 4338630 0 0 0 0 3 14 3543 20758 0.000846023688663282 0.000174504417422474 0.00247043033885164 0.999326015790487 0.998869427329123 0.999631479131688 0.176470588235294 0.0379850680706259 0.434317872844283 NA NA NA 0 0 0.231635761650116 NA NA NA NA 1661 1879 False False 1.25547356961412 0.231209142607805 4.50153926394258 0 0 0.00104063215855229 0.999326015790487 0.998869427329123 0.999631479131688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.192C>A whiB6_c.192C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin whiB6 c.-195_-93del whiB6_c.-195_-93del 2 upstream_gene_variant 4338613 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1622 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.195C>T whiB6_c.195C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin whiB6 c.-198_-31del whiB6_c.-198_-31del 2 upstream_gene_variant 4338551 NA 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1615 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 886 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-198_-42del whiB6_c.-198_-42del 2 upstream_gene_variant 4338562 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.198C>T whiB6_c.198C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin whiB6 c.-19T>C whiB6_c.-19T>C 2 upstream_gene_variant 4338540 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.1A>T whiB6_c.1A>T 2 initiator_codon_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.150201697158088 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin whiB6 c.-205_-62del whiB6_c.-205_-62del 2 upstream_gene_variant 4338582 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-206_-65del whiB6_c.-206_-65del 2 upstream_gene_variant 4338585 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.213T>C whiB6_c.213T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.2177754884198 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin whiB6 c.21A>C whiB6_c.21A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin whiB6 c.21A>G whiB6_c.21A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin whiB6 c.-21A>G whiB6_c.-21A>G 2 upstream_gene_variant 4338542 1 3 0 3 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 14.1776055911046 1 193 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.57085126512166 1 233 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-22A>G whiB6_c.-22A>G 2 upstream_gene_variant 4338543 NA 0 0 0 2 0 3544 20772 0.000564015792442188 6.83122290578968e-05 0.00203591855262226 1 0.99982242673208 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1563 1879 False False Inf 1.10031452590981 Inf 0 0 0.0010403386792448 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.231A>C whiB6_c.231A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 7 3546 20765 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.06480602430196 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin whiB6 c.-240_-28del whiB6_c.-240_-28del 2 upstream_gene_variant 4338548 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1564 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-24G>A whiB6_c.-24G>A 2 upstream_gene_variant 4338545 1 1 0 1 1 6 3545 20766 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999711149624494 0.999371401166804 0.999893989862555 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.975 0 0 0.4592581264399 0 0 227.657160397059 1 617 1879 False False 0.976304654442877 0.0212191705766405 8.05133152464184 0 0 0.00104004536542481 0.999711149624494 0.999371401166804 0.999893989862555 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 2 1606 6351 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.99968518810011 0.99886325869706 0.999961872544366 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 897 992 False False 0 0 0 0 0 0 0 1.97727272727272 0.0334940093351611 38.0316888278718 0 0 0.00229430020901157 0.99968518810011 0.99886325869706 0.999961872544366 6 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-24G>C whiB6_c.-24G>C 2 upstream_gene_variant 4338545 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.252A>G whiB6_c.252A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.2177754884198 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin whiB6 c.-25G>A whiB6_c.-25G>A 2 upstream_gene_variant 4338546 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 7 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-26A>C whiB6_c.-26A>C 2 upstream_gene_variant 4338547 1 5 0 5 0 5 3546 20767 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 6.39361750002021 1 617 1879 False False 0 0 6.39361750002021 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-26A>G whiB6_c.-26A>G 2 upstream_gene_variant 4338547 1 1 0 1 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 227.636869136849 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-27_-26insG whiB6_c.-27_-26insG 2 upstream_gene_variant 4338547 1 1 0 1 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 227.636869136849 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 849 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-27G>A whiB6_c.-27G>A 2 upstream_gene_variant 4338548 1 1 0 1 0 5 3546 20767 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 0 0 0.521823750104981 0 0 0.975 0 0 0.521823750104981 0 0 227.60410798126 1 617 1879 False False 0 0 6.39361750002021 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 153.76339448854 1 233 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 2 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.288A>G whiB6_c.288A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 27 53 3519 20719 0.00761421319796954 0.00502363711934746 0.0110590800267931 0.997448488349701 0.996663871893852 0.9980881763603 0.3375 0.23552613798365 0.451905614374168 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.99942093326255 1.81121536947585 4.86205330904317 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 19 50 1588 6303 0.0118232731798382 0.00713297860434726 0.0184021699639553 0.992129702502754 0.989637007250091 0.994153033006725 0.275362318840579 0.17462595264843 0.39615080871708 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.50827455919395 0.837192489323552 2.61256764786825 NA NA NA NA NA NA 18 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin whiB6 c.294G>A whiB6_c.294G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin whiB6 c.-29A>G whiB6_c.-29A>G 2 upstream_gene_variant 4338550 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-29A>T whiB6_c.-29A>T 2 upstream_gene_variant 4338550 1 4 0 4 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 8.87534793394977 1 617 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 1607 6349 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.99028746746614 0.589339945669686 68 992 False False 0 0 0 0 0 0 0 0 0 5.99028746746614 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 11 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-2T>C whiB6_c.-2T>C 2 upstream_gene_variant 4338523 1 4 0 4 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 8.87534793394977 1 617 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.303C>G whiB6_c.303C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin whiB6 c.30A>G whiB6_c.30A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin whiB6 c.-30G>C whiB6_c.-30G>C 2 upstream_gene_variant 4338551 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.312C>T whiB6_c.312C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin whiB6 c.318G>T whiB6_c.318G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.2177754884198 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin whiB6 c.-31A>C whiB6_c.-31A>C 2 upstream_gene_variant 4338552 NA 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1648 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 907 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-31A>G whiB6_c.-31A>G 2 upstream_gene_variant 4338552 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.324C>T whiB6_c.324C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin whiB6 c.330G>A whiB6_c.330G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.2177754884198 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin whiB6 c.-33G>A whiB6_c.-33G>A 2 upstream_gene_variant 4338554 NA 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1576 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 862 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-33G>C whiB6_c.-33G>C 2 upstream_gene_variant 4338554 NA 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1594 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-34G>A whiB6_c.-34G>A 2 upstream_gene_variant 4338555 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-42G>T whiB6_c.-42G>T 2 upstream_gene_variant 4338563 0 0 0 0 200 111 3346 20661 0.0564015792442188 0.049035817800141 0.0645088373777442 0.994656268053148 0.993568283635383 0.995602037847932 0.643086816720257 0.587067635488524 0.696350820629601 NA NA NA 0 0 0.0326869940239477 NA NA NA NA 1548 1879 False False 11.1258299542818 8.74998510505048 14.2088089690945 0 0 0.00110186693172136 0.994656268053148 0.993568283635383 0.995602037847932 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 137 76 1470 6277 0.0852520224019912 0.0720546907172737 0.0999865160495068 0.988037147804186 0.985049287429711 0.99056337281585 0.64319248826291 0.57486489215327 0.707472092694083 NA NA NA 0 0 0.0473787538669306 NA NA NA NA 842 992 False False 0 0 0 0 0 0 0 7.69735947010383 5.73652881712661 10.3861129561936 0 0 0.00250629578856442 0.988037147804186 0.985049287429711 0.99056337281585 427 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.42T>G whiB6_c.42T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 14.1782880202046 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.0580478247511 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin whiB6 c.-44C>T whiB6_c.-44C>T 2 upstream_gene_variant 4338565 1 4 0 4 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 8.87534793394977 1 617 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 11 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.45C>T whiB6_c.45C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin whiB6 c.-46C>A whiB6_c.-46C>A 2 upstream_gene_variant 4338567 NA 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1662 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 919 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.49A>C whiB6_c.49A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 20 27 3526 20745 0.00564015792442188 0.00344845723940479 0.00869738875319159 0.998700173310225 0.998109379648872 0.999143236725131 0.425531914893617 0.282579006783499 0.57821525257538 NA NA NA NA NA NA NA NA NA NA NA NA False False 4.35810172055208 2.31435769308458 8.0766129192082 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 2 1605 6351 0.00124455507156191 0.000150756945780856 0.00448845844972244 0.99968518810011 0.99886325869706 0.999961872544366 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.95700934579439 0.286553713541028 54.5786958645469 NA NA NA NA NA NA 16 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin whiB6 c.-49C>T whiB6_c.-49C>T 2 upstream_gene_variant 4338570 1 1 0 1 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 227.636869136849 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-51C>T whiB6_c.-51C>T 2 upstream_gene_variant 4338572 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1631 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.51G>A whiB6_c.51G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.150201697158088 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin whiB6 c.-54A>G whiB6_c.-54A>G 2 upstream_gene_variant 4338575 1 0 0 0 3 37 3543 20735 0.000846023688663282 0.000174504417422474 0.00247043033885164 0.998218756017716 0.997545617335941 0.998745539331288 0.075 0.0157421798510415 0.203864748732898 NA NA NA 0 0 0.0948905874149899 NA NA NA NA 1600 1879 False False 0.474517701444035 0.0935533504489234 1.49990946876945 0 0 0.00104063215855229 0.998218756017716 0.997545617335941 0.998745539331288 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 1607 6348 0 0 0.0022928741555424 0.999212970250275 0.99816429885228 0.999744405769873 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 874 992 False False 0 0 0 0 0 0 0 0 0 4.31499754664604 0 0 0.0022928741555424 0.999212970250275 0.99816429885228 0.999744405769873 32 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-54A>T whiB6_c.-54A>T 2 upstream_gene_variant 4338575 1 0 0 0 1 2 3545 20770 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999903716541498 0.99965223478104 0.999988339413789 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1560 1879 False False 2.92947813822284 0.0496406430315194 56.2247306595764 0 0 0.00104004536542481 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.54C>T whiB6_c.54C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 3546 20766 0 0 0.0010397522169524 0.999711149624494 0.999371401166804 0.999893989862555 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.9758630843129 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin whiB6 c.-57C>G whiB6_c.-57C>G 2 upstream_gene_variant 4338578 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-59A>C whiB6_c.-59A>C 2 upstream_gene_variant 4338580 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-5G>A whiB6_c.-5G>A 2 upstream_gene_variant 4338526 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1636 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.60C>T whiB6_c.60C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin whiB6 c.-62C>T whiB6_c.-62C>T 2 upstream_gene_variant 4338583 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1551 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-66T>C whiB6_c.-66T>C 2 upstream_gene_variant 4338587 1 1 0 1 1 1 3545 20771 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999951858270749 0.999731800967312 0.999998781157685 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 227.711777615967 1 617 1879 False False 5.8592383638928 0.0746220616644107 458.169367733398 0 0 0.00104004536542481 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 28 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-67C>T whiB6_c.-67C>T 2 upstream_gene_variant 4338588 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-68G>T whiB6_c.-68G>T 2 upstream_gene_variant 4338589 1 0 0 0 1 2 3545 20770 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999903716541498 0.99965223478104 0.999988339413789 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1540 1879 False False 2.92947813822284 0.0496406430315194 56.2247306595764 0 0 0.00104004536542481 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-69A>C whiB6_c.-69A>C 2 upstream_gene_variant 4338590 1 7 0 7 0 7 3546 20765 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 4.06480602430196 0.603472689124846 144 1879 False False 0 0 4.06480602430196 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 1607 6347 0 0 0.0022928741555424 0.99905556430033 0.997945503023207 0.999653332387469 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.35786664322939 0.607610106306186 81 992 False False 0 0 0 0 0 0 0 0 0 3.35786664322939 0 0 0.0022928741555424 0.99905556430033 0.997945503023207 0.999653332387469 73 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-69A>G whiB6_c.-69A>G 2 upstream_gene_variant 4338590 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1663 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 920 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-69A>T whiB6_c.-69A>T 2 upstream_gene_variant 4338590 1 3 0 3 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 14.1782880202046 1 617 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.0580478247511 1 233 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 20 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-70G>A whiB6_c.-70G>A 2 upstream_gene_variant 4338591 1 1 0 1 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 227.636869136849 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-70G>C whiB6_c.-70G>C 2 upstream_gene_variant 4338591 1 2 0 2 11 30 3535 20742 0.00310208685843203 0.0015495363119703 0.00554369603206677 0.998555748122472 0.99793887730437 0.99902536376823 0.268292682926829 0.142213003340871 0.429444705266082 0 0 0.841886116991581 0 0 0.115703308222027 0 0 31.2736310544432 1 617 1879 False False 2.15145685997171 0.971826872086256 4.42110150010368 0 0 0.0010429859674069 0.998555748122472 0.99793887730437 0.99902536376823 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 2 1605 6351 0.00124455507156191 0.000150756945780856 0.00448845844972244 0.99968518810011 0.99886325869706 0.999961872544366 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 887 992 False False 0 0 0 0 0 0 0 3.95700934579439 0.286553713541028 54.5786958645469 0 0 0.0022957280374523 0.99968518810011 0.99886325869706 0.999961872544366 8 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-71G>A whiB6_c.-71G>A 2 upstream_gene_variant 4338592 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-71G>C whiB6_c.-71G>C 2 upstream_gene_variant 4338592 1 3 0 3 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 14.1782880202046 1 617 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.0580478247511 1 233 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 8 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-71G>T whiB6_c.-71G>T 2 upstream_gene_variant 4338592 1 1 0 1 0 16 3546 20756 0 0 0.0010397522169524 0.999229732331985 0.998749434152838 0.999559663409708 0 0 0.205907214207822 0 0 0.975 0 0 0.205907214207822 0 0 227.483983456121 1 617 1879 False False 0 0 1.51862445866705 0 0 0.0010397522169524 0.999229732331985 0.998749434152838 0.999559663409708 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 899 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 7 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.72C>T whiB6_c.72C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin whiB6 c.-75_-72delGCTCinsCAA whiB6_c.-75_-72delGCTCinsCAA 2 upstream_gene_variant 4338593 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-75_-72delGCTCinsCTG whiB6_c.-75_-72delGCTCinsCTG 2 upstream_gene_variant 4338593 1 4 0 4 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 8.87534793394977 1 617 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-75_-72delGCTCinsCTT whiB6_c.-75_-72delGCTCinsCTT 2 upstream_gene_variant 4338593 1 3 0 3 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 14.1776055911046 1 193 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-75_-73delGCTinsCA whiB6_c.-75_-73delGCTinsCA 2 upstream_gene_variant 4338594 1 21 1 20 3 24 3543 20748 0.000846023688663282 0.000174504417422474 0.00247043033885164 0.998844598497978 0.998281338770479 0.999259576566422 0.111111111111111 0.0235274543808539 0.291586924273551 0.0476190476190476 0.00120488344836351 0.238159909936821 0.04 0.00101219969931084 0.203516913922414 0.292802709568162 0.00706573743880089 1.83189583796086 0.348965610809175 103 1879 False False 0.732006773920406 0.141043542078191 2.41236536668788 0.00028216704288939 7.1438254941256e-06 0.00157112051380901 0.998844598497978 0.998281338770479 0.999259576566422 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 2 4 1605 6349 0.00124455507156191 0.000150756945780856 0.00448845844972244 0.99937037620022 0.998388704765699 0.99982842290899 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.841886116991581 0 0 0.602364635616474 0 0 21.0776158705918 1 233 992 False False 0 0 0 0 0 0 0 1.97788161993769 0.178739259054919 13.8135366697626 0 0 0.0022957280374523 0.99937037620022 0.998388704765699 0.99982842290899 23 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-75_-73delGCTinsCC whiB6_c.-75_-73delGCTinsCC 2 upstream_gene_variant 4338594 1 49 0 49 12 76 3534 20696 0.00338409475465313 0.00174979607500839 0.00590386326830579 0.99634122857693 0.99542261142497 0.99711625380988 0.136363636363636 0.0724938996271756 0.226087553660857 0 0 0.0725192636642774 0 0 0.0473787538669306 0 0 0.458169949369706 0.000794164285074375 20 1879 False False 0.924671611116075 0.457236642357211 1.71301065174363 0 0 0.00104328094242513 0.99634122857693 0.99542261142497 0.99711625380988 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 20 0 20 6 35 1601 6318 0.00373366521468575 0.00137138406067734 0.00810877842801138 0.994490791751928 0.992346277097125 0.996159723233545 0.146341463414634 0.0556573637124366 0.291730488017494 0 0 0.168433470983085 0 0 0.100032435572105 0 0 0.800446971369767 0.0214481936497051 19 992 False False 0 0 0 0 0 0 0 0.676505755331489 0.232186761341955 1.62931838461253 0 0 0.00230145716737395 0.994490791751928 0.992346277097125 0.996159723233545 72 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-75_-73delGCTinsCG whiB6_c.-75_-73delGCTinsCG 2 upstream_gene_variant 4338594 1 14 0 14 9 31 3537 20741 0.00253807106598984 0.001161204060764 0.00481255792904073 0.998507606393221 0.997882329473034 0.998985772699289 0.225 0.108396638984072 0.384511677303422 0 0 0.231635761650116 0 0 0.11218874692237 0 0 1.76870042530673 0.245363606332859 86 1879 False False 1.70245423951407 0.712269559520264 3.66717023889901 0 0 0.0010423965174912 0.998507606393221 0.997882329473034 0.998985772699289 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 5 14 1602 6339 0.00311138767890479 0.00101100708660053 0.00724588638281331 0.997796316700771 0.996305355363671 0.99879471848905 0.263157894736842 0.0914657849076665 0.512029345345872 0 0 0.707598226178713 0 0 0.231635761650116 0 0 9.58410548448509 1 233 992 False False 0 0 0 0 0 0 0 1.41318887105403 0.397767180425635 4.1594320964535 0 0 0.00230002220580469 0.997796316700771 0.996305355363671 0.99879471848905 60 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-75_-74delGCinsA whiB6_c.-75_-74delGCinsA 2 upstream_gene_variant 4338595 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 2 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-75_-74delGCinsT whiB6_c.-75_-74delGCinsT 2 upstream_gene_variant 4338595 1 1 0 1 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 227.636869136849 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 153.787547206498 1 233 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 12 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-75_-74insA whiB6_c.-75_-74insA 2 upstream_gene_variant 4338595 0 0 0 0 1 10 3545 20762 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.99951858270749 0.999114835261082 0.999769118326375 0.0909090909090909 0.00229897221381426 0.412779916988382 NA NA NA 0 0 0.30849710781876 NA NA NA NA 1577 1879 False False 0.585669957686882 0.0134948626376594 4.11922590459154 0 0 0.00104004536542481 0.99951858270749 0.999114835261082 0.999769118326375 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 3 1606 6350 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.999527782150165 0.998620605323549 0.999902606737868 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 863 992 False False 0 0 0 0 0 0 0 1.31797426317974 0.0250900413291082 16.4244635399174 0 0 0.00229430020901157 0.999527782150165 0.998620605323549 0.999902606737868 5 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.75C>T whiB6_c.75C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin whiB6 c.-75delG whiB6_c.-75delG 2 upstream_gene_variant 4338595 NA 0 0 0 3450 20061 96 711 0.972927241962774 0.967038965038109 0.97801720896079 0.0342287694974003 0.0317975368965221 0.036791459111123 0.146739823912211 0.142239417007862 0.151327742562471 NA NA NA 0 0 0.000183866223695384 NA NA NA NA 1535 1879 False True 1.27369336025123 1.02456004978209 1.59807798343532 0 0 0.0376969216235875 0.0342287694974003 0.0317975368965221 0.036791459111123 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 1564 6120 43 233 0.973242065961418 0.964125124508503 0.980568981632731 0.0366755863371635 0.0321886512030739 0.0415940329592683 0.203539823008849 0.194586036772554 0.212719034319848 NA NA NA 0 0 0.000602576458578864 NA NA NA NA 835 992 False True 0 1 1 0 0 0 0 1.38475452196382 0.991409556767898 1.97404359915452 0 0 0.0822111211541385 0.0366755863371635 0.0321886512030739 0.0415940329592683 27003 5) Not assoc w R New NotAwR yes 5 +Kanamycin whiB6 c.-75G>A whiB6_c.-75G>A 2 upstream_gene_variant 4338596 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1574 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-75G>T whiB6_c.-75G>T 2 upstream_gene_variant 4338596 NA 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1572 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 859 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-76_-75delAG whiB6_c.-76_-75delAG 2 upstream_gene_variant 4338595 0 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1623 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-76_-75delAGinsC whiB6_c.-76_-75delAGinsC 2 upstream_gene_variant 4338596 1 10 1 9 1 13 3545 20759 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999374157519738 0.998930028080923 0.99966672449503 0.0714285714285714 0.00180678065912538 0.338684489931821 0.1 0.00252857854446178 0.445016117028195 0.0714285714285714 0.00180678065912538 0.338684489931821 0.650650368280833 0.0148436054911704 4.69804791585549 1 617 1879 False False 0.450450254963654 0.0105996549108314 3.00077742545747 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999374157519738 0.998930028080923 0.99966672449503 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 153.76339448854 1 233 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 24 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-76_-75delAGinsT whiB6_c.-76_-75delAGinsT 2 upstream_gene_variant 4338596 1 14 1 13 1 14 3545 20758 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999326015790487 0.998869427329123 0.999631479131688 0.0666666666666666 0.0016864302413527 0.319484566578303 0.0714285714285714 0.00180678065912538 0.338684489931821 0.0666666666666666 0.0016864302413527 0.319484566578303 0.450428555929261 0.0105991444926764 3.00063298847263 0.707994783137614 161 1879 False False 0.418255087648599 0.00989216454442892 2.7507499999788 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999326015790487 0.998869427329123 0.999631479131688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 153.787547206498 1 233 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 9 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-76A>C whiB6_c.-76A>C 2 upstream_gene_variant 4338597 NA 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1657 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 915 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-76delA whiB6_c.-76delA 2 upstream_gene_variant 4338596 1 1 0 1 0 6 3546 20766 0 0 0.0010397522169524 0.999711149624494 0.999371401166804 0.999893989862555 0 0 0.4592581264399 0 0 0.975 0 0 0.4592581264399 0 0 227.593187588584 1 193 1879 False False 0 0 4.9758630843129 0 0 0.0010397522169524 0.999711149624494 0.999371401166804 0.999893989862555 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 864 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 13 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-77_-75delGAGinsAA whiB6_c.-77_-75delGAGinsAA 2 upstream_gene_variant 4338596 1 3 0 3 1 5 3545 20767 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999759291353745 0.999438356476751 0.999921838086342 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.707598226178713 0 0 0.521823750104981 0 0 14.1809220336365 1 617 1879 False False 1.17162200282087 0.0247643691956443 10.4748703386698 0 0 0.00104004536542481 0.999759291353745 0.999438356476751 0.999921838086342 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 2 1606 6351 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.99968518810011 0.99886325869706 0.999961872544366 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 836 992 False False 0 0 0 0 0 0 0 1.97727272727272 0.0334940093351611 38.0316888278718 0 0 0.00229430020901157 0.99968518810011 0.99886325869706 0.999961872544366 17 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-77_-75delGAGinsCA whiB6_c.-77_-75delGAGinsCA 2 upstream_gene_variant 4338596 1 15 0 15 0 20 3546 20752 0 0 0.0010397522169524 0.999037165414981 0.998513369831025 0.9994117795557 0 0 0.168433470983085 0 0 0.218019360910534 0 0 0.168433470983085 0 0 1.63252432447622 0.149535923184347 75 1879 False False 0 0 1.18605048536415 0 0 0.0010397522169524 0.999037165414981 0.998513369831025 0.9994117795557 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 0 12 1607 6341 0 0 0.0022928741555424 0.998111128600661 0.99670284884972 0.999023623643625 0 0 0.264648469397051 0 0 0.369416647552819 0 0 0.264648469397051 0 0 2.31431353961695 0.371712235684044 58 992 False False 0 0 0 0 0 0 0 0 0 1.42192958878239 0 0 0.0022928741555424 0.998111128600661 0.99670284884972 0.999023623643625 26 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-78_-75delAGAGinsCGA whiB6_c.-78_-75delAGAGinsCGA 2 upstream_gene_variant 4338596 1 20 1 19 6 33 3540 20739 0.00169204737732656 0.000621196730345483 0.00367920983862615 0.998411322934719 0.997769623498813 0.998906183277335 0.153846153846153 0.0586242628607893 0.305279924436712 0.05 0.0012650894979498 0.248732762772027 0.0294117647058823 0.00074436423469026 0.153267669560317 0.308340767172167 0.0074221246088392 1.94092107634313 0.344624788230661 102 1879 False False 1.06517719568567 0.364572612110797 2.57689828244817 0.000282406099971759 7.14987785217869e-06 0.00157245073668775 0.998411322934719 0.997769623498813 0.998906183277335 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 1 9 1606 6344 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.998583346450495 0.997312461277908 0.999352017626566 0.1 0.00252857854446178 0.445016117028195 0 0 0.602364635616474 0 0 0.336267116879942 0 0 5.98930143523731 0.589326837637267 64 992 False False 0 0 0 0 0 0 0 0.438909644389096 0.0100110022233902 3.17195020844629 0 0 0.00229430020901157 0.998583346450495 0.997312461277908 0.999352017626566 64 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-78_-75delAGAGinsGGA whiB6_c.-78_-75delAGAGinsGGA 2 upstream_gene_variant 4338596 1 3 0 3 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 14.1776055911046 1 193 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-78delA whiB6_c.-78delA 2 upstream_gene_variant 4338598 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1578 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-79_-78delTAinsC whiB6_c.-79_-78delTAinsC 2 upstream_gene_variant 4338599 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1595 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 871 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-79T>C whiB6_c.-79T>C 2 upstream_gene_variant 4338600 1 72 2 70 10 78 3536 20694 0.00282007896221094 0.00135314014136576 0.00518009078773565 0.996244945118428 0.995315705416587 0.997030687301002 0.113636363636363 0.0558579759508812 0.199067856713038 0.0277777777777777 0.00338190032617324 0.0967672891134151 0.025 0.00304208616480959 0.0874071559305922 0.167210730446024 0.0198560851087101 0.62752659924972 0.0021093377289714 22 1879 False False 0.750304559693699 0.345879346122021 1.45641155803009 0.000565291124929338 6.84667107922764e-05 0.0020405187002701 0.996244945118428 0.995315705416587 0.997030687301002 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 4 8 1603 6345 0.00248911014312383 0.000678602218007884 0.00636074311848652 0.99874075240044 0.997520296036287 0.99945619445686 0.333333333333333 0.0992460911495833 0.651124493581186 0 0 0.4592581264399 0 0 0.369416647552819 0 0 3.36520209984367 0.607430066274287 79 992 False False 0 0 0 0 0 0 0 1.97910168434185 0.435536467373573 7.39769146433191 0 0 0.00229858903252049 0.99874075240044 0.997520296036287 0.99945619445686 31 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-79T>G whiB6_c.-79T>G 2 upstream_gene_variant 4338600 1 10 1 9 2 22 3544 20750 0.000564015792442188 6.83122290578968e-05 0.00203591855262226 0.99894088195648 0.998396919060608 0.999336141078939 0.0833333333333333 0.0102563412812501 0.269972801557603 0.1 0.00252857854446178 0.445016117028195 0.0434782608695652 0.0011001686304415 0.21948660745348 0.650551793328317 0.0148413560628683 4.69733709484372 1 193 1879 False False 0.532269649086804 0.0606518177442616 2.16677991004422 0.000282087447108603 7.14181031782542e-06 0.001570677606179 0.99894088195648 0.998396919060608 0.999336141078939 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 8 1607 6345 0 0 0.0022928741555424 0.99874075240044 0.997520296036287 0.99945619445686 0 0 0.369416647552819 0 0 0.602364635616474 0 0 0.369416647552819 0 0 5.98651822215824 0.589290182703008 62.5 992 False False 0 0 0 0 0 0 0 0 0 2.31577290672845 0 0 0.0022928741555424 0.99874075240044 0.997520296036287 0.99945619445686 21 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-80_-71delCTAGAGCTCG whiB6_c.-80_-71delCTAGAGCTCG 2 upstream_gene_variant 4338591 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1561 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-81_-74delACTAGAGC whiB6_c.-81_-74delACTAGAGC 2 upstream_gene_variant 4338594 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-81_-78delACTAinsTCC whiB6_c.-81_-78delACTAinsTCC 2 upstream_gene_variant 4338599 1 3 0 3 1 11 3545 20761 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.99947044097824 0.999052670645628 0.99973561734751 0.0833333333333333 0.00210759323186022 0.384796165150944 0 0 0.707598226178713 0 0 0.284914152918154 0 0 14.1768263035872 1 617 1879 False False 0.532401589947429 0.0123687722233094 3.66537636152503 0 0 0.00104004536542481 0.99947044097824 0.999052670645628 0.99973561734751 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 4 1606 6349 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.99937037620022 0.998388704765699 0.99982842290899 0.2 0.00505076337946806 0.716417936118089 0 0 0.975 0 0 0.602364635616474 0 0 153.83473969981 1 233 992 False False 0 0 0 0 0 0 0 0.98832503113325 0.0200561540991659 9.99322371223062 0 0 0.00229430020901157 0.99937037620022 0.998388704765699 0.99982842290899 2 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-81_-80delAC whiB6_c.-81_-80delAC 2 upstream_gene_variant 4338600 1 3 0 3 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 14.1782880202046 1 617 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-81A>T whiB6_c.-81A>T 2 upstream_gene_variant 4338602 0 0 0 0 1 4 3545 20768 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999807433082996 0.99950702628237 0.999947529583666 0.2 0.00505076337946806 0.716417936118089 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1632 1879 False False 1.46459802538787 0.0297312351170663 14.8120229375093 0 0 0.00104004536542481 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 893 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 6 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.81T>C whiB6_c.81T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 3546 20766 0 0 0.0010397522169524 0.999711149624494 0.999371401166804 0.999893989862555 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.9758630843129 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 6 1607 6347 0 0 0.0022928741555424 0.99905556430033 0.997945503023207 0.999653332387469 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.35786664322939 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin whiB6 c.-82_-27delCACTAGAGCTCGGAGCTCGCCGAACCGGAGCCGCAGCACCGCTAGGCAGGCAGAGG whiB6_c.-82_-27delCACTAGAGCTCGGAGCTCGCCGAACCGGAGCCGCAGCACCGCTAGGCAGGCAGAGG 2 upstream_gene_variant 4338547 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-82C>T whiB6_c.-82C>T 2 upstream_gene_variant 4338603 NA 0 0 0 30 1308 3516 19464 0.00846023688663282 0.00571515760395069 0.0120556527842865 0.937030618139803 0.933641613099012 0.940296669634552 0.0224215246636771 0.0151776262475089 0.0318543658095574 NA NA NA 0 0 0.00281627107817752 NA NA NA NA 1596 1879 False True 0.126968719666844 0.0851448473147247 0.182512723944987 0 0 0.00104861916981122 0.937030618139803 0.933641613099012 0.940296669634552 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 7 249 1600 6104 0.0043559427504667 0.00175305387776039 0.00895419084394721 0.960805918463718 0.955739127137466 0.965443835633422 0.02734375 0.0110627868084981 0.0555245905471426 NA NA NA 0 0 0.0147055780339792 NA NA NA NA 872 992 False True 1 1 1 0 0 0 0 0.107248995983935 0.0426044749081819 0.224953360632688 0 0 0.00230289392057743 0.960805918463718 0.955739127137466 0.965443835633422 2890 5) Not assoc w R New NotAwR yes 5 +Kanamycin whiB6 c.-83G>A whiB6_c.-83G>A 2 upstream_gene_variant 4338604 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-84C>G whiB6_c.-84C>G 2 upstream_gene_variant 4338605 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-84C>T whiB6_c.-84C>T 2 upstream_gene_variant 4338605 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1645 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-86C>T whiB6_c.-86C>T 2 upstream_gene_variant 4338607 NA 0 0 0 1 3 3545 20769 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999855574812247 0.999577986903419 0.999970215063798 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1601 1879 False False 1.95289139633286 0.0371893922070044 24.3461286113284 0 0 0.00104004536542481 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 875 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 7 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.87C>T whiB6_c.87C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 3545 20771 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999951858270749 0.999731800967312 0.999998781157685 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 5.8592383638928 0.0746220616644107 458.169367733398 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin whiB6 c.-87delG whiB6_c.-87delG 2 upstream_gene_variant 4338607 NA 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1658 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 916 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-87G>A whiB6_c.-87G>A 2 upstream_gene_variant 4338608 NA 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1549 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 843 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-88delT whiB6_c.-88delT 2 upstream_gene_variant 4338608 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-8T>G whiB6_c.-8T>G 2 upstream_gene_variant 4338529 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-91C>T whiB6_c.-91C>T 2 upstream_gene_variant 4338612 1 0 0 0 1 2 3545 20770 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999903716541498 0.99965223478104 0.999988339413789 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1624 1879 False False 2.92947813822284 0.0496406430315194 56.2247306595764 0 0 0.00104004536542481 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-93G>C whiB6_c.-93G>C 2 upstream_gene_variant 4338614 1 4 0 4 0 5 3546 20767 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 8.87492061244508 1 193 1879 False False 0 0 6.39361750002021 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 900 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 18 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-94C>T whiB6_c.-94C>T 2 upstream_gene_variant 4338615 NA 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1664 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-96C>G whiB6_c.-96C>G 2 upstream_gene_variant 4338617 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.96C>T whiB6_c.96C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 3545 20771 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999951858270749 0.999731800967312 0.999998781157685 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 5.8592383638928 0.0746220616644107 458.169367733398 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin whiB6 c.-97_-95delACT whiB6_c.-97_-95delACT 2 upstream_gene_variant 4338615 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1616 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-97A>C whiB6_c.-97A>C 2 upstream_gene_variant 4338618 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1556 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-99_-98insCTGG whiB6_c.-99_-98insCTGG 2 upstream_gene_variant 4338619 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-99G>T whiB6_c.-99G>T 2 upstream_gene_variant 4338620 1 2 0 2 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 31.21472012401 1 617 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.-9C>A whiB6_c.-9C>A 2 upstream_gene_variant 4338530 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 c.9C>T whiB6_c.9C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 10 49 3536 20723 0.00282007896221094 0.00135314014136576 0.00518009078773565 0.997641055266705 0.996882534958946 0.998254345736684 0.169491525423728 0.0843901510753911 0.289688456373857 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.19603610675039 0.539640306343187 2.39293983090999 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 4 29 1603 6324 0.00248911014312383 0.000678602218007884 0.00636074311848652 0.995435227451597 0.993450754193271 0.996940832844943 0.121212121212121 0.0340328814229786 0.28201622853722 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.544152128552068 0.138803461722377 1.55288644212405 NA NA NA NA NA NA 37 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin whiB6 c.-9C>T whiB6_c.-9C>T 2 upstream_gene_variant 4338530 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1584 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 deletion whiB6_deletion 2 feature_ablation (see "Genomic_coordinates" sheet) 1 1 0 1 13 33 3533 20739 0.00366610265087422 0.00195344498124592 0.00626098788620239 0.998411322934719 0.997769623498813 0.998906183277335 0.282608695652173 0.159866701924902 0.43460407778425 0 0 0.975 0 0 0.105762810074579 0 0 228.131719531492 1 617 1879 False False 2.31245657823636 1.11578612224839 4.51712819716506 0 0 0.00104357608433894 0.998411322934719 0.997769623498813 0.998906183277335 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 4 13 1603 6340 0.00248911014312383 0.000678602218007884 0.00636074311848652 0.997953722650716 0.996503345413809 0.998910007694291 0.235294117647058 0.0681077404373566 0.49899327320458 0 0 0.975 0 0 0.24705263800047 0 0 153.904031455547 1 233 992 False False 0 0 0 0 0 0 0 1.21694898987475 0.288662509529051 3.94619645336276 0 0 0.00229858903252049 0.997953722650716 0.996503345413809 0.998910007694291 40 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 LoF whiB6_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 120 2 118 52 374 3494 20398 0.0146644106034968 0.0109709612479589 0.0191864320612633 0.981994993260158 0.980093699394911 0.983759622323224 0.12206572769953 0.0925231770646446 0.156976632787105 0.0166666666666666 0.00202482233769308 0.0589092194670267 0.00531914893617021 0.000644823997222065 0.0190815594164167 0.0989492883684379 0.0118233751878034 0.365737302411186 2.91176075662742e-06 12 1879 True False 0.811701648968897 0.593895260260674 1.08981680437359 0.0005720823798627 6.92893405419311e-05 0.00206501462304979 0.981994993260158 0.980093699394911 0.983759622323224 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 34 0 34 25 115 1582 6238 0.0155569383945239 0.0100922701578006 0.022879941630961 0.981898315756335 0.978311196717353 0.985032662199208 0.178571428571428 0.119022275577726 0.252218202922163 0 0 0.102817924259012 0 0 0.0315681959882471 0 0 0.452585755847006 0.000837210301485291 11 992 False False 0 0 0 0 0 0 0 0.857197823338646 0.530826889428094 1.33546337495056 0 0 0.00232906571636742 0.981898315756335 0.978311196717353 0.985032662199208 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Ala14Gly whiB6_p.Ala14Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Ala25Pro whiB6_p.Ala25Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1562 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Ala25Ser whiB6_p.Ala25Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1552 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Ala49Asp whiB6_p.Ala49Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 12 3546 20760 0 0 0.0010397522169524 0.999422299248989 0.998991090727643 0.999701459098715 0 0 0.264648469397051 NA NA NA 0 0 0.264648469397051 NA NA NA NA 1668 1879 False False 0 0 2.1081669380099 0 0 0.0010397522169524 0.999422299248989 0.998991090727643 0.999701459098715 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 9 1607 6344 0 0 0.0022928741555424 0.998583346450495 0.997312461277908 0.999352017626566 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 922 992 False False 0 0 0 0 0 0 0 0 0 2.00246403812054 0 0 0.0022928741555424 0.998583346450495 0.997312461277908 0.999352017626566 2 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Ala49Val whiB6_p.Ala49Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Ala55Asp whiB6_p.Ala55Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 14.1782880202046 1 617 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Ala55Pro whiB6_p.Ala55Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1588 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Ala63Glu whiB6_p.Ala63Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 7 3546 20765 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 0 0 0.409616397225003 0 0 0.975 0 0 0.409616397225003 0 0 227.582267192168 1 617 1879 False False 0 0 4.06480602430196 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Ala63Thr whiB6_p.Ala63Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 227.625948755393 1 617 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 865 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 4 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Ala63Val whiB6_p.Ala63Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 14.1782880202046 1 617 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Ala66Pro whiB6_p.Ala66Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 7 3546 20765 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 4.06480602430196 0.603472689124846 144 1879 False False 0 0 4.06480602430196 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 7 1607 6346 0 0 0.0022928741555424 0.998898158350385 0.997731111129242 0.999556891392146 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 2.74289259224573 0.357346851251029 48.5 992 False False 0 0 0 0 0 0 0 0 0 2.74289259224573 0 0 0.0022928741555424 0.998898158350385 0.997731111129242 0.999556891392146 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Ala66Thr whiB6_p.Ala66Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 18 1 17 13 24 3533 20748 0.00366610265087422 0.00195344498124592 0.00626098788620239 0.998844598497978 0.998281338770479 0.999259576566422 0.351351351351351 0.202099815284002 0.525388744373974 0.0555555555555555 0.00140555616736942 0.272943599673368 0.04 0.00101219969931084 0.203516913922414 0.345448793726378 0.00826689070633738 2.20608133586101 0.500443824640439 126 1879 False False 3.18100764223039 1.48592564644557 6.50675345593749 0.000282965478211658 7.16403998168853e-06 0.00157556336722323 0.998844598497978 0.998281338770479 0.999259576566422 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 13 1 12 11 14 1596 6339 0.00684505289359054 0.00342183249163077 0.012214612742384 0.997796316700771 0.996305355363671 0.99879471848905 0.44 0.244023665147208 0.650718366008664 0.0769230769230769 0.00194562849734675 0.360297435267877 0.0666666666666666 0.0016864302413527 0.319484566578303 0.330983709273182 0.00774141973656528 2.24022913161271 0.486350452801566 60 992 False False 0 0 0 0 0 0 0 3.12070354457572 1.27916608585747 7.41560258691158 0.000626174076393237 1.58532293670952e-05 0.0034838291252252 0.997796316700771 0.996305355363671 0.99879471848905 37 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Ala66Val whiB6_p.Ala66Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 7 3546 20765 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 0 0 0.409616397225003 0 0 0.602364635616474 0 0 0.409616397225003 0 0 8.87406596942854 1 617 1879 False False 0 0 4.06480602430196 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 153.787547206498 1 233 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 5 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Ala6Glu whiB6_p.Ala6Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1669 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Ala6Ser whiB6_p.Ala6Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Ala72fs whiB6_p.Ala72fs 2 frameshift (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 3546 20766 0 0 0.0010397522169524 0.999711149624494 0.999371401166804 0.999893989862555 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 4.9758630843129 0.60210064118223 134 1879 False False 0 0 4.9758630843129 0 0 0.0010397522169524 0.999711149624494 0.999371401166804 0.999893989862555 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 1607 6349 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.99028746746614 0.589339945669686 68 992 False False 0 0 0 0 0 0 0 0 0 5.99028746746614 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 29 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Ala72Glu whiB6_p.Ala72Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 5 3545 20767 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999759291353745 0.999438356476751 0.999921838086342 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.841886116991581 0 0 0.521823750104981 0 0 31.2221435503209 1 617 1879 False False 1.17162200282087 0.0247643691956443 10.4748703386698 0 0 0.00104004536542481 0.999759291353745 0.999438356476751 0.999921838086342 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 850 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Ala72Gly whiB6_p.Ala72Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 2 4 3544 20768 0.000564015792442188 6.83122290578968e-05 0.00203591855262226 0.999807433082996 0.99950702628237 0.999947529583666 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.707598226178713 0 0 0.602364635616474 0 0 14.1856059777447 1 617 1879 False False 2.93002257336343 0.264933806373958 20.4509238425525 0 0 0.0010403386792448 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 1606 6351 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.99968518810011 0.99886325869706 0.999961872544366 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 153.883075087497 1 233 992 False False 0 0 0 0 0 0 0 1.97727272727272 0.0334940093351611 38.0316888278718 0 0 0.00229430020901157 0.99968518810011 0.99886325869706 0.999961872544366 4 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Ala72Val whiB6_p.Ala72Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Ala77fs whiB6_p.Ala77fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 2 2 3544 20770 0.000564015792442188 6.83122290578968e-05 0.00203591855262226 0.999903716541498 0.99965223478104 0.999988339413789 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 227.764875202926 1 193 1879 False False 5.86060948081264 0.424646188620106 80.7055921553874 0 0 0.0010403386792448 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 1605 6353 0.00124455507156191 0.000150756945780856 0.00448845844972244 1 0.999419516970794 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 844 992 False False 0 0 0 0 0 0 0 Inf 0.742689158362403 Inf 0 0 0.0022957280374523 1 0.999419516970794 1 5 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Ala77Glu whiB6_p.Ala77Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 31.21472012401 1 617 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 3 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Ala77Ser whiB6_p.Ala77Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 2 9 3544 20763 0.000564015792442188 6.83122290578968e-05 0.00203591855262226 0.999566724436741 0.999177668076772 0.99980186029375 0.181818181818181 0.0228311982999596 0.517755852360172 0 0 0.369416647552819 0 0 0.336267116879942 0 0 3.43382366238844 0.612873960020156 154 1879 False False 1.30191873589164 0.136853683255704 6.29262336365321 0 0 0.0010403386792448 0.999566724436741 0.999177668076772 0.99980186029375 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 1 4 1606 6349 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.99937037620022 0.998388704765699 0.99982842290899 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.99401592025988 0.589389153087337 71.5 992 False False 0 0 0 0 0 0 0 0.98832503113325 0.0200561540991659 9.99322371223062 0 0 0.00229430020901157 0.99937037620022 0.998388704765699 0.99982842290899 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Ala77Val whiB6_p.Ala77Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 54 107 3492 20665 0.015228426395939 0.0114602222742216 0.0198235836552226 0.994848834970152 0.993778688385585 0.995776632263256 0.335403726708074 0.263028803567612 0.413965844766429 0 0 0.707598226178713 0 0 0.0338879994740114 0 0 14.325456463122 1 617 1879 False False 2.98655939878601 2.10771242077762 4.1885468207118 0 0 0.00105582236842124 0.994848834970152 0.993778688385585 0.995776632263256 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 13 20 1594 6333 0.00808960796515245 0.00431420272810426 0.0137937485453152 0.996851881001102 0.995142152726785 0.99807601929298 0.393939393939393 0.2290662383642 0.578606278611749 0 0 0.975 0 0 0.168433470983085 0 0 154.600455819941 1 233 992 False False 0 0 0 0 0 0 0 2.58246549560853 1.17759506412435 5.46742180214502 0 0 0.00231155225272827 0.996851881001102 0.995142152726785 0.99807601929298 5 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Ala87Val whiB6_p.Ala87Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 227.636869136849 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 845 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 2 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Ala89fs whiB6_p.Ala89fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1550 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 846 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Ala89Glu whiB6_p.Ala89Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Ala91Glu whiB6_p.Ala91Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 31.2162477992404 1 193 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 891 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Ala91Gly whiB6_p.Ala91Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1565 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 853 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Ala91Thr whiB6_p.Ala91Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1665 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Ala91Val whiB6_p.Ala91Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 227.636869136849 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Ala99Pro whiB6_p.Ala99Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1589 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 868 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Ala99Thr whiB6_p.Ala99Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Ala99Val whiB6_p.Ala99Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 3545 20771 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999951858270749 0.999731800967312 0.999998781157685 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 227.711777615967 1 617 1879 False False 5.8592383638928 0.0746220616644107 458.169367733398 0 0 0.00104004536542481 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 17 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Ala9Ser whiB6_p.Ala9Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 5 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Ala9Val whiB6_p.Ala9Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Arg101Cys whiB6_p.Arg101Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 3546 20767 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 8.87492061244508 1 193 1879 False False 0 0 6.39361750002021 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 153.787547206498 1 233 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 6 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Arg107Cys whiB6_p.Arg107Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 12 404 3534 20368 0.00338409475465313 0.00174979607500839 0.00590386326830579 0.98055074138263 0.978579989042862 0.982385324919144 0.0288461538461538 0.0149922030850145 0.0498459358064057 NA NA NA 0 0 0.00908932975360521 NA NA NA NA 1677 1879 False True 0.171191312679655 0.0876134016120273 0.302792088544246 0 0 0.00104328094242513 0.98055074138263 0.978579989042862 0.982385324919144 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 4 95 1603 6258 0.00248911014312383 0.000678602218007884 0.00636074311848652 0.985046434755233 0.981750522069028 0.98788527513038 0.0404040404040404 0.0111167487985759 0.100227906568749 NA NA NA 0 0 0.0380860775700105 NA NA NA NA 926 992 False True 1 1 1 0 0 0 0 0.164376005515973 0.0438275124091406 0.435933434579515 0 0 0.00229858903252049 0.985046434755233 0.981750522069028 0.98788527513038 417 5) Not assoc w R New NotAwR yes 5 +Kanamycin whiB6 p.Arg107fs whiB6_p.Arg107fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 3545 20771 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999951858270749 0.999731800967312 0.999998781157685 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1579 1879 False False 5.8592383638928 0.0746220616644107 458.169367733398 0 0 0.00104004536542481 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Arg107Pro whiB6_p.Arg107Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1609 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Arg110Trp whiB6_p.Arg110Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 10 0 10 0 10 3546 20762 0 0 0.0010397522169524 0.99951858270749 0.999114835261082 0.999769118326375 0 0 0.30849710781876 0 0 0.30849710781876 0 0 0.30849710781876 0 0 2.61340113759526 0.375738934230534 108 1879 False False 0 0 2.61340113759526 0 0 0.0010397522169524 0.99951858270749 0.999114835261082 0.999769118326375 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.0580478247511 1 233 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 4 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Arg17fs whiB6_p.Arg17fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1530 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Arg17Gly whiB6_p.Arg17Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 3 20 3543 20752 0.000846023688663282 0.000174504417422474 0.00247043033885164 0.999037165414981 0.998513369831025 0.9994117795557 0.130434782608695 0.0277515074227932 0.335889137537121 0 0 0.841886116991581 0 0 0.168433470983085 0 0 31.2171259934903 1 617 1879 False False 0.878577476714648 0.167088202767378 2.96454731014534 0 0 0.00104063215855229 0.999037165414981 0.998513369831025 0.9994117795557 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 5 1606 6348 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.999212970250275 0.99816429885228 0.999744405769873 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA 0 0 0.521823750104981 NA NA NA NA 901 992 False False 0 0 0 0 0 0 0 0.790535491905354 0.0167037613038365 7.07198409929284 0 0 0.00229430020901157 0.999212970250275 0.99816429885228 0.999744405769873 11 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Arg17Lys whiB6_p.Arg17Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 10 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Arg17Ser whiB6_p.Arg17Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 11 1 10 1 10 3545 20762 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.99951858270749 0.999114835261082 0.999769118326375 0.0909090909090909 0.00229897221381426 0.412779916988382 0.0909090909090909 0.00229897221381426 0.412779916988382 0.0909090909090909 0.00229897221381426 0.412779916988382 0.585669957686882 0.0134948626376594 4.11922590459154 1 193 1879 False False 0.585669957686882 0.0134948626376594 4.11922590459154 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.99951858270749 0.999114835261082 0.999769118326375 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Arg2fs whiB6_p.Arg2fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1649 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 908 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Arg40Cys whiB6_p.Arg40Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 6 3545 20766 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999711149624494 0.999371401166804 0.999893989862555 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.841886116991581 0 0 0.4592581264399 0 0 31.2206153902525 1 617 1879 False False 0.976304654442877 0.0212191705766405 8.05133152464184 0 0 0.00104004536542481 0.999711149624494 0.999371401166804 0.999893989862555 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 894 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 2 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Arg40His whiB6_p.Arg40His 2 missense_variant (see "Genomic_coordinates" sheet) 1 13 0 13 0 15 3546 20757 0 0 0.0010397522169524 0.999277874061236 0.998809242329947 0.999595777053137 0 0 0.218019360910534 0 0 0.24705263800047 0 0 0.218019360910534 0 0 1.92169933515892 0.237586055075226 83 1879 False False 0 0 1.6329175925414 0 0 0.0010397522169524 0.999277874061236 0.998809242329947 0.999595777053137 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 153.76339448854 1 233 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 11 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Arg54fs whiB6_p.Arg54fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1585 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Arg54Gln whiB6_p.Arg54Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 102 3545 20670 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.995089543616406 0.994042174625712 0.99599438847363 0.00970873786407766 0.000245773753693975 0.0529082867402035 NA NA NA 0 0 0.035519326657884 NA NA NA NA 1602 1879 False True 0.0571641914875964 0.00143708081316397 0.325956731499688 0 0 0.00104004536542481 0.995089543616406 0.994042174625712 0.99599438847363 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 36 1607 6317 0 0 0.0022928741555424 0.994333385801983 0.99216356736318 0.996028110243192 0 0 0.0973937559144919 NA NA NA 0 0 0.0973937559144919 NA NA NA NA 876 992 False True 1 1 1 0 0 0 0 0 0 0.424759967591413 0 0 0.0022928741555424 0.994333385801983 0.99216356736318 0.996028110243192 885 5) Not assoc w R New NotAwR yes 5 +Kanamycin whiB6 p.Arg54Gly whiB6_p.Arg54Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 2 5 3544 20767 0.000564015792442188 6.83122290578968e-05 0.00203591855262226 0.999759291353745 0.999438356476751 0.999921838086342 0.285714285714285 0.0366925661760855 0.709579136262657 0 0 0.841886116991581 0 0 0.521823750104981 0 0 31.2311001692477 1 617 1879 False False 2.34390519187359 0.223103783292547 14.3213786605059 0 0 0.0010403386792448 0.999759291353745 0.999438356476751 0.999921838086342 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 7 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Arg54Pro whiB6_p.Arg54Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 8 3546 20764 0 0 0.0010397522169524 0.999614866165992 0.999241274614236 0.99983371235125 0 0 0.369416647552819 0 0 0.707598226178713 0 0 0.369416647552819 0 0 14.1748758749384 1 617 1879 False False 0 0 3.43205141622579 0 0 0.0010397522169524 0.999614866165992 0.999241274614236 0.99983371235125 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Arg54Trp whiB6_p.Arg54Trp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1686 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Arg58Cys whiB6_p.Arg58Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1580 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Arg58fs whiB6_p.Arg58fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1650 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 909 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Arg58Gly whiB6_p.Arg58Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1633 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 895 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Arg58Leu whiB6_p.Arg58Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1625 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Arg58Pro whiB6_p.Arg58Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1597 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 873 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Arg59Gln whiB6_p.Arg59Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1646 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Arg59Leu whiB6_p.Arg59Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1670 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Arg59Pro whiB6_p.Arg59Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1671 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Arg59Trp whiB6_p.Arg59Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 9 3546 20763 0 0 0.0010397522169524 0.999566724436741 0.999177668076772 0.99980186029375 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1610 1879 False False 0 0 2.96786458045639 0 0 0.0010397522169524 0.999566724436741 0.999177668076772 0.99980186029375 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 881 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 2 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Arg64Cys whiB6_p.Arg64Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1651 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Arg64fs whiB6_p.Arg64fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 7 3546 20765 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1678 1879 False False 0 0 4.06480602430196 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 927 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 2 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Arg64His whiB6_p.Arg64His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 10 0 3536 20772 0.00282007896221094 0.00135314014136576 0.00518009078773565 1 0.99982242673208 1 1 0.691502892181239 1 NA NA NA NA NA NA NA NA NA NA 1653 1879 False False Inf 13.1575987762091 Inf 0 0 0.00104269115914271 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 10 0 1597 6353 0.00622277535780958 0.00298797623318756 0.0114140395320774 1 0.999419516970794 1 1 0.691502892181239 1 NA NA NA NA NA NA NA NA NA NA 911 992 False False 0 0 0 0 0 0 0 Inf 8.90231564837059 Inf 0 0 0.00230721496361062 1 0.999419516970794 1 2 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Arg64Leu whiB6_p.Arg64Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 3545 20770 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999903716541498 0.99965223478104 0.999988339413789 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 227.70085417967 1 193 1879 False False 2.92947813822284 0.0496406430315194 56.2247306595764 0 0 0.00104004536542481 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Arg86fs whiB6_p.Arg86fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 31.2162477992404 1 193 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 4 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Arg86Gln whiB6_p.Arg86Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Arg86Pro whiB6_p.Arg86Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Arg86Trp whiB6_p.Arg86Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 3 3545 20769 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999855574812247 0.999577986903419 0.999970215063798 0.25 0.00630946320970987 0.805879550316756 0 0 0.975 0 0 0.707598226178713 0 0 227.68993073963 1 193 1879 False False 1.95289139633286 0.0371893922070044 24.3461286113284 0 0 0.00104004536542481 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.0580478247511 1 233 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Arg88Gln whiB6_p.Arg88Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1603 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 877 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Arg88Gly whiB6_p.Arg88Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Arg88Leu whiB6_p.Arg88Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.0580478247511 1 233 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Arg88Trp whiB6_p.Arg88Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 18 3545 20754 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999133448873483 0.998630820056588 0.999486348579758 0.0526315789473684 0.00133162880417942 0.260280654195214 0 0 0.707598226178713 0 0 0.185301968137852 0 0 14.172047952926 1 617 1879 False False 0.32524682651622 0.00780745855307623 2.06132383955558 0 0 0.00104004536542481 0.999133448873483 0.998630820056588 0.999486348579758 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 11 1606 6342 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.998268534550606 0.996904046831145 0.999135351755422 0.0833333333333333 0.00210759323186022 0.384796165150944 0 0 0.841886116991581 0 0 0.284914152918154 0 0 21.0413454095561 1 233 992 False False 0 0 0 0 0 0 0 0.358994679044492 0.00833869553663541 2.4734928655095 0 0 0.00229430020901157 0.998268534550606 0.996904046831145 0.999135351755422 23 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Arg96Pro whiB6_p.Arg96Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1626 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Arg96* whiB6_p.Arg96* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 1 5 3545 20767 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999759291353745 0.999438356476751 0.999921838086342 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1654 1879 False False 1.17162200282087 0.0247643691956443 10.4748703386698 0 0 0.00104004536542481 0.999759291353745 0.999438356476751 0.999921838086342 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 912 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 7 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Asn102Asp whiB6_p.Asn102Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 227.625948755393 1 617 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 10 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Asn102fs whiB6_p.Asn102fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1557 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Asn13Ser whiB6_p.Asn13Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Asn18Thr whiB6_p.Asn18Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Asp108fs whiB6_p.Asp108fs 2 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 7 3 3539 20769 0.00197405527354765 0.000794029400507555 0.00406305244102797 0.999855574812247 0.999577986903419 0.999970215063798 0.7 0.347547149940002 0.933260488822265 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1566 1879 False False 13.6934162192709 3.12348620290615 82.0622698035943 0 0 0.00104180773346159 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 1604 6353 0.00186683260734287 0.000385151348909821 0.00544589495836224 1 0.999419516970794 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 854 992 False False 0 0 0 0 0 0 0 Inf 1.63477030328606 Inf 0 0 0.00229715764418053 1 0.999419516970794 1 2 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Asp20Ala whiB6_p.Asp20Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.150201697158088 Inf 0.14581791265729 60 1879 False False Inf 0.150201697158088 Inf 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Asp37Gly whiB6_p.Asp37Gly 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 8 3545 20764 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999614866165992 0.999241274614236 0.99983371235125 0.111111111111111 0.00280913674659921 0.482496514917337 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1541 1879 False False 0.73215796897038 0.0164955563131374 5.46332200200716 0 0 0.00104004536542481 0.999614866165992 0.999241274614236 0.99983371235125 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Asp37His whiB6_p.Asp37His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1627 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Asp39fs whiB6_p.Asp39fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 2 2 3544 20770 0.000564015792442188 6.83122290578968e-05 0.00203591855262226 0.999903716541498 0.99965223478104 0.999988339413789 0.5 0.067585986488543 0.932414013511457 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2356862724826 1 193 1879 False False 5.86060948081264 0.424646188620106 80.7055921553874 0 0 0.0010403386792448 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 830 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 6 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Asp39Gly whiB6_p.Asp39Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1652 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Asp46Ala whiB6_p.Asp46Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 31.21472012401 1 617 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Asp46Glu whiB6_p.Asp46Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 4 3545 20768 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999807433082996 0.99950702628237 0.999947529583666 0.2 0.00505076337946806 0.716417936118089 0 0 0.707598226178713 0 0 0.602364635616474 0 0 14.1816046553931 1 617 1879 False False 1.46459802538787 0.0297312351170663 14.8120229375093 0 0 0.00104004536542481 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Asp46Gly whiB6_p.Asp46Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 3545 20770 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999903716541498 0.99965223478104 0.999988339413789 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2267281142718 1 617 1879 False False 2.92947813822284 0.0496406430315194 56.2247306595764 0 0 0.00104004536542481 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Asp46His whiB6_p.Asp46His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 2 3544 20770 0.000564015792442188 6.83122290578968e-05 0.00203591855262226 0.999903716541498 0.99965223478104 0.999988339413789 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1687 1879 False False 5.86060948081264 0.424646188620106 80.7055921553874 0 0 0.0010403386792448 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 931 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Asp47fs whiB6_p.Asp47fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1590 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 869 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Asp47Gly whiB6_p.Asp47Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 5 3546 20767 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1679 1879 False False 0 0 6.39361750002021 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Asp65Ala whiB6_p.Asp65Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1531 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 831 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Asp65fs whiB6_p.Asp65fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Asp65Gly whiB6_p.Asp65Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1598 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Asp65Tyr whiB6_p.Asp65Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 3 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Cys12Ser whiB6_p.Cys12Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 4 3545 20768 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999807433082996 0.99950702628237 0.999947529583666 0.2 0.00505076337946806 0.716417936118089 1 0.025 1 0.2 0.00505076337946806 0.716417936118089 Inf 0.150172773259056 Inf 0.145841901784979 72 1879 False False 1.46459802538787 0.0297312351170663 14.8120229375093 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1607 6349 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 917 992 False False 0 0 0 0 0 0 0 0 0 5.99028746746614 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 11 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Cys34Trp whiB6_p.Cys34Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Cys34Tyr whiB6_p.Cys34Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 4 3545 20768 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999807433082996 0.99950702628237 0.999947529583666 0.2 0.00505076337946806 0.716417936118089 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1666 1879 False False 1.46459802538787 0.0297312351170663 14.8120229375093 0 0 0.00104004536542481 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 921 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Cys53Arg whiB6_p.Cys53Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 1 7 12 36 3534 20736 0.00338409475465313 0.00174979607500839 0.00590386326830579 0.998266897746967 0.997601455379579 0.998785870383798 0.25 0.1363722774206 0.395959310027117 0.125 0.0031597235312519 0.526509670875206 0.027027027027027 0.000684031024694665 0.141603095611158 0.83822459374242 0.0185934274491627 6.52790447719798 1 617 1879 False False 1.95585738539898 0.925547872769876 3.85096678810416 0.000282885431400282 7.16201338640503e-06 0.0015751179514767 0.998266897746967 0.997601455379579 0.998785870383798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 4 16 1603 6337 0.00248911014312383 0.000678602218007884 0.00636074311848652 0.997481504800881 0.995913335169992 0.998559798442438 0.2 0.0573339970500327 0.436614002996668 0 0 0.521823750104981 0 0 0.205907214207822 0 0 4.31827857682272 0.590291712475342 73 992 False False 0 0 0 0 0 0 0 0.988303181534622 0.240109846900781 3.06923711605059 0 0 0.00229858903252049 0.997481504800881 0.995913335169992 0.998559798442438 80 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Cys53fs whiB6_p.Cys53fs 2 frameshift (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 14.1776055911046 1 193 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 153.787547206498 1 233 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Cys53Gly whiB6_p.Cys53Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 2 36 3544 20736 0.000564015792442188 6.83122290578968e-05 0.00203591855262226 0.998266897746967 0.997601455379579 0.998785870383798 0.0526315789473684 0.00643871671509191 0.17749059034764 0 0 0.409616397225003 0 0 0.0973937559144919 0 0 4.06142076629907 0.603479617268541 152 1879 False False 0.325056433408577 0.0379028970395206 1.26360869768957 0 0 0.0010403386792448 0.998266897746967 0.997601455379579 0.998785870383798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 8 1607 6345 0 0 0.0022928741555424 0.99874075240044 0.997520296036287 0.99945619445686 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 882 992 False False 0 0 0 0 0 0 0 0 0 2.31577290672845 0 0 0.0022928741555424 0.99874075240044 0.997520296036287 0.99945619445686 25 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Cys53Phe whiB6_p.Cys53Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 227.636869136849 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Cys53Ser whiB6_p.Cys53Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1543 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 839 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Cys53* whiB6_p.Cys53* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1542 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 838 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Cys53Trp whiB6_p.Cys53Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 31.21472012401 1 617 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 12 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Cys53Tyr whiB6_p.Cys53Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1604 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Cys56fs whiB6_p.Cys56fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 31.2162477992404 1 193 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Cys56Gly whiB6_p.Cys56Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1575 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Cys56Tyr whiB6_p.Cys56Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1618 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Cys62Arg whiB6_p.Cys62Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1680 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 928 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Cys62fs whiB6_p.Cys62fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 227.636869136849 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Cys62Ser whiB6_p.Cys62Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1672 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Cys62* whiB6_p.Cys62* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1641 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 902 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Cys62Tyr whiB6_p.Cys62Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1659 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Gln114fs whiB6_p.Gln114fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 3 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Gln36* whiB6_p.Gln36* 2 stop_gained (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 3546 20767 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 8.87492061244508 1 193 1879 False False 0 0 6.39361750002021 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 21.0547398420152 1 233 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 2 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Gln94Glu whiB6_p.Gln94Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 218 2 216 3 256 3543 20516 0.000846023688663282 0.000174504417422474 0.00247043033885164 0.987675717311765 0.986081076972059 0.989131598116509 0.0115830115830115 0.00239509500233598 0.0334754175101934 0.0091743119266055 0.00111298922602856 0.0327460028535766 0.00775193798449612 0.000940178229104417 0.0277205572435483 0.0536164163034047 0.00645559840080931 0.196217751567726 1.27791057377956e-12 8 1879 True False 0.0678582768839966 0.0138956720809298 0.20075229117305 0.000564174894217207 6.83315011404289e-05 0.00203649243647685 0.987675717311765 0.986081076972059 0.989131598116509 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 3 1606 6350 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.999527782150165 0.998620605323549 0.999902606737868 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 21.0678257313609 1 233 992 False False 0 0 0 0 0 0 0 1.31797426317974 0.0250900413291082 16.4244635399174 0 0 0.00229430020901157 0.999527782150165 0.998620605323549 0.999902606737868 641 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Gln94His whiB6_p.Gln94His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1628 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 892 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Gln94* whiB6_p.Gln94* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 1 2 3545 20770 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999903716541498 0.99965223478104 0.999988339413789 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1532 1879 False False 2.92947813822284 0.0496406430315194 56.2247306595764 0 0 0.00104004536542481 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 832 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Glu100fs whiB6_p.Glu100fs 2 frameshift (see "Genomic_coordinates" sheet) 1 13 0 13 0 15 3546 20757 0 0 0.0010397522169524 0.999277874061236 0.998809242329947 0.999595777053137 0 0 0.218019360910534 0 0 0.24705263800047 0 0 0.218019360910534 0 0 1.92169933515892 0.237586055075226 83 1879 False False 0 0 1.6329175925414 0 0 0.0010397522169524 0.999277874061236 0.998809242329947 0.999595777053137 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.0580478247511 1 233 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 17 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Glu100* whiB6_p.Glu100* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Glu28fs whiB6_p.Glu28fs 2 frameshift (see "Genomic_coordinates" sheet) 1 10 0 10 0 20 3546 20752 0 0 0.0010397522169524 0.999037165414981 0.998513369831025 0.9994117795557 0 0 0.168433470983085 0 0 0.30849710781876 0 0 0.168433470983085 0 0 2.61214262182472 0.37574612681846 112 1879 False False 0 0 1.18605048536415 0 0 0.0010397522169524 0.999037165414981 0.998513369831025 0.9994117795557 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 11 1607 6342 0 0 0.0022928741555424 0.998268534550606 0.996904046831145 0.999135351755422 0 0 0.284914152918154 0 0 0.521823750104981 0 0 0.284914152918154 0 0 4.31092025951698 0.590298621397058 78 992 False False 0 0 0 0 0 0 0 0 0 1.57440756412985 0 0 0.0022928741555424 0.998268534550606 0.996904046831145 0.999135351755422 12 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Glu28Gln whiB6_p.Glu28Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 5 3546 20767 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 0 0 0.521823750104981 0 0 0.841886116991581 0 0 0.521823750104981 0 0 31.2131924627285 1 617 1879 False False 0 0 6.39361750002021 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Glu28Lys whiB6_p.Glu28Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 8.87534793394977 1 617 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 1607 6349 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.99028746746614 0.589339945669686 68 992 False False 0 0 0 0 0 0 0 0 0 5.99028746746614 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 3 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Glu48_Thr51delinsAla whiB6_p.Glu48_Thr51delinsAla 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Glu48fs whiB6_p.Glu48fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Glu68* whiB6_p.Glu68* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Glu73fs whiB6_p.Glu73fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1637 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Glu73* whiB6_p.Glu73* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1567 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 855 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Glu83Lys whiB6_p.Glu83Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Glu83* whiB6_p.Glu83* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1629 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Glu8Ala whiB6_p.Glu8Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1642 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 903 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Glu8Asp whiB6_p.Glu8Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 15 0 15 0 18 3546 20754 0 0 0.0010397522169524 0.999133448873483 0.998630820056588 0.999486348579758 0 0 0.185301968137852 0 0 0.218019360910534 0 0 0.185301968137852 0 0 1.63268163174258 0.149538886375563 76 1879 False False 0 0 1.33197531668918 0 0 0.0010397522169524 0.999133448873483 0.998630820056588 0.999486348579758 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 0 11 0 12 1607 6341 0 0 0.0022928741555424 0.998111128600661 0.99670284884972 0.999023623643625 0 0 0.264648469397051 0 0 0.284914152918154 0 0 0.264648469397051 0 0 1.57415941071689 0.135682664401858 27 992 False False 0 0 0 0 0 0 0 0 0 1.42192958878239 0 0 0.0022928741555424 0.998111128600661 0.99670284884972 0.999023623643625 27 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Glu8fs whiB6_p.Glu8fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Glu8Gly whiB6_p.Glu8Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 7 3544 20765 0.000564015792442188 6.83122290578968e-05 0.00203591855262226 0.999663007895243 0.999305791518941 0.999864501305137 0.222222222222222 0.0281449734778982 0.600093573716312 0 0 0.975 0 0 0.409616397225003 0 0 227.710242663801 1 193 1879 False False 1.67405675588519 0.169596128350343 8.79734879915306 0 0 0.0010403386792448 0.999663007895243 0.999305791518941 0.999864501305137 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 6 1605 6347 0.00124455507156191 0.000150756945780856 0.00448845844972244 0.99905556430033 0.997945503023207 0.999653332387469 0.25 0.0318540262499442 0.650855794412824 NA NA NA 0 0 0.4592581264399 NA NA NA NA 904 992 False False 0 0 0 0 0 0 0 1.31817237798546 0.1300202372935 7.38070474973144 0 0 0.0022957280374523 0.99905556430033 0.997945503023207 0.999653332387469 3 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Glu8Lys whiB6_p.Glu8Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 10 3546 20762 0 0 0.0010397522169524 0.99951858270749 0.999114835261082 0.999769118326375 0 0 0.30849710781876 NA NA NA 0 0 0.30849710781876 NA NA NA NA 1655 1879 False False 0 0 2.61340113759526 0 0 0.0010397522169524 0.99951858270749 0.999114835261082 0.999769118326375 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 913 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 25 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Glu8Val whiB6_p.Glu8Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Gly32Ser whiB6_p.Gly32Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1553 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Gly74Arg whiB6_p.Gly74Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1638 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 898 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Gly74Glu whiB6_p.Gly74Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1536 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Gly78fs whiB6_p.Gly78fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1611 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 883 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Gly78Glu whiB6_p.Gly78Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 227.636869136849 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 153.787547206498 1 233 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Gly78Val whiB6_p.Gly78Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 3 3545 20769 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999855574812247 0.999577986903419 0.999970215063798 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1643 1879 False False 1.95289139633286 0.0371893922070044 24.3461286113284 0 0 0.00104004536542481 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Gly85Ala whiB6_p.Gly85Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1612 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Gly85Arg whiB6_p.Gly85Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1613 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 884 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Gly85Asp whiB6_p.Gly85Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 8 3546 20764 0 0 0.0010397522169524 0.999614866165992 0.999241274614236 0.99983371235125 0 0 0.369416647552819 0 0 0.975 0 0 0.369416647552819 0 0 227.571346792012 1 617 1879 False False 0 0 3.43205141622579 0 0 0.0010397522169524 0.999614866165992 0.999241274614236 0.99983371235125 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 856 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 2 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Gly85fs whiB6_p.Gly85fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 3 6 3543 20766 0.000846023688663282 0.000174504417422474 0.00247043033885164 0.999711149624494 0.999371401166804 0.999893989862555 0.333333333333333 0.0748546314196918 0.700704943791459 0 0 0.975 0 0 0.4592581264399 0 0 227.785213965102 1 617 1879 False False 2.93056731583403 0.473985690537044 13.7236245333568 0 0 0.00104063215855229 0.999711149624494 0.999371401166804 0.999893989862555 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 5 1604 6348 0.00186683260734287 0.000385151348909821 0.00544589495836224 0.999212970250275 0.99816429885228 0.999744405769873 0.375 0.0852334141372535 0.755136783633448 0 0 0.975 0 0 0.521823750104981 0 0 154.001894248768 1 86 992 False False 0 0 0 0 0 0 0 2.37456359102244 0.368320189349033 12.2207446954396 0 0 0.00229715764418053 0.999212970250275 0.99816429885228 0.999744405769873 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Gly85Ser whiB6_p.Gly85Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 12 0 12 0 16 3546 20756 0 0 0.0010397522169524 0.999229732331985 0.998749434152838 0.999559663409708 0 0 0.205907214207822 0 0 0.264648469397051 0 0 0.205907214207822 0 0 2.10776053493188 0.235502319304768 81 1879 False False 0 0 1.51862445866705 0 0 0.0010397522169524 0.999229732331985 0.998749434152838 0.999559663409708 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 1607 6349 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.56934488045651 1 86 992 False False 0 0 0 0 0 0 0 0 0 5.99028746746614 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 48 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Gly85Val whiB6_p.Gly85Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Gly93fs whiB6_p.Gly93fs 2 frameshift (see "Genomic_coordinates" sheet) 1 7 0 7 0 8 3546 20764 0 0 0.0010397522169524 0.999614866165992 0.999241274614236 0.99983371235125 0 0 0.369416647552819 0 0 0.409616397225003 0 0 0.369416647552819 0 0 4.06461026139319 0.603473084876286 149 1879 False False 0 0 3.43205141622579 0 0 0.0010397522169524 0.999614866165992 0.999241274614236 0.99983371235125 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 10 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.His109fs whiB6_p.His109fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.His109Gln whiB6_p.His109Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1591 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 870 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Ile81Thr whiB6_p.Ile81Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Leu26fs whiB6_p.Leu26fs 2 frameshift (see "Genomic_coordinates" sheet) 1 4 0 4 0 6 3546 20766 0 0 0.0010397522169524 0.999711149624494 0.999371401166804 0.999893989862555 0 0 0.4592581264399 0 0 0.602364635616474 0 0 0.4592581264399 0 0 8.874493290938 1 617 1879 False False 0 0 4.9758630843129 0 0 0.0010397522169524 0.999711149624494 0.999371401166804 0.999893989862555 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 3 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Leu31fs whiB6_p.Leu31fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 5 3546 20767 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1528 1879 False False 0 0 6.39361750002021 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 827 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 5 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Leu31Phe whiB6_p.Leu31Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1681 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 929 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Leu52fs whiB6_p.Leu52fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 7 3546 20765 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 0 0 0.409616397225003 0 0 0.975 0 0 0.409616397225003 0 0 227.582267192168 1 617 1879 False False 0 0 4.06480602430196 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Leu52Gln whiB6_p.Leu52Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 14 0 14 0 17 3546 20755 0 0 0.0010397522169524 0.999181590602734 0.998689969592855 0.99952317637802 0 0 0.195064322969093 0 0 0.231635761650116 0 0 0.195064322969093 0 0 1.76540395184983 0.245540049394577 87 1879 False False 0 0 1.41921002298157 0 0 0.0010397522169524 0.999181590602734 0.998689969592855 0.99952317637802 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 1607 6347 0 0 0.0022928741555424 0.99905556430033 0.997945503023207 0.999653332387469 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.35786664322939 0.607610106306186 81 992 False False 0 0 0 0 0 0 0 0 0 3.35786664322939 0 0 0.0022928741555424 0.99905556430033 0.997945503023207 0.999653332387469 21 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Leu52Pro whiB6_p.Leu52Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 14.1776055911046 1 193 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Leu52* whiB6_p.Leu52* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Leu61fs whiB6_p.Leu61fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1544 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Leu75fs whiB6_p.Leu75fs 2 frameshift (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 14.1776055911046 1 193 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Leu75Gln whiB6_p.Leu75Gln 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 2 3543 20770 0.000846023688663282 0.000174504417422474 0.00247043033885164 0.999903716541498 0.99965223478104 0.999988339413789 0.6 0.146632799634673 0.947255049473683 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1558 1879 False False 8.79339542760372 1.00678482242299 105.331235646919 0 0 0.00104063215855229 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 2 1605 6351 0.00124455507156191 0.000150756945780856 0.00448845844972244 0.99968518810011 0.99886325869706 0.999961872544366 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 851 992 False False 0 0 0 0 0 0 0 3.95700934579439 0.286553713541028 54.5786958645469 0 0 0.0022957280374523 0.99968518810011 0.99886325869706 0.999961872544366 25 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Leu75Met whiB6_p.Leu75Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1619 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 888 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Leu92fs whiB6_p.Leu92fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Leu92Ser whiB6_p.Leu92Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 20 2 3526 20770 0.00564015792442188 0.00344845723940479 0.00869738875319159 0.999903716541498 0.99965223478104 0.999988339413789 0.909090909090909 0.708387258446066 0.988794413975849 1 0.158113883008419 1 0.5 0.067585986488543 0.932414013511457 Inf 1.10582236205983 Inf 0.0210770999359508 33 1879 False False 58.9052750992626 14.2922317717527 519.249438678935 0.000566893424036281 6.86607982812445e-05 0.00204629820077483 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 847 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 3 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Leu95Ala whiB6_p.Leu95Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1545 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 840 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Leu95Arg whiB6_p.Leu95Arg 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 8 3542 20764 0.00112803158488437 0.000307433460438748 0.00288566784728404 0.999614866165992 0.999241274614236 0.99983371235125 0.333333333333333 0.0992460911495833 0.651124493581186 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1573 1879 False False 2.93111236589497 0.645516623437799 10.9449563451265 0 0 0.00104092580348739 0.999614866165992 0.999241274614236 0.99983371235125 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1607 6349 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 860 992 False False 0 0 0 0 0 0 0 0 0 5.99028746746614 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 2 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Leu95del whiB6_p.Leu95del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1614 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 885 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Leu95Pro whiB6_p.Leu95Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 227.636869136849 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 4 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Leu95Val whiB6_p.Leu95Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Leu98Arg whiB6_p.Leu98Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 31.2162477992404 1 193 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Leu98fs whiB6_p.Leu98fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 9 3546 20763 0 0 0.0010397522169524 0.999566724436741 0.999177668076772 0.99980186029375 0 0 0.336267116879942 0 0 0.975 0 0 0.336267116879942 0 0 227.560426388115 1 617 1879 False False 0 0 2.96786458045639 0 0 0.0010397522169524 0.999566724436741 0.999177668076772 0.99980186029375 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 924 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 17 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Leu98Pro whiB6_p.Leu98Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 3543 20772 0.000846023688663282 0.000174504417422474 0.00247043033885164 1 0.99982242673208 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1682 1879 False False Inf 2.42140315163361 Inf 0 0 0.00104063215855229 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 1605 6353 0.00124455507156191 0.000150756945780856 0.00448845844972244 1 0.999419516970794 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 930 992 False False 0 0 0 0 0 0 0 Inf 0.742689158362403 Inf 0 0 0.0022957280374523 1 0.999419516970794 1 2 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Leu98Val whiB6_p.Leu98Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Lys50Asn whiB6_p.Lys50Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 3545 20771 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999951858270749 0.999731800967312 0.999998781157685 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1537 1879 False False 5.8592383638928 0.0746220616644107 458.169367733398 0 0 0.00104004536542481 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 837 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 4 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Lys50Gln whiB6_p.Lys50Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1683 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Lys50Glu whiB6_p.Lys50Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1538 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Lys50* whiB6_p.Lys50* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Lys50Thr whiB6_p.Lys50Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 2 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Met1? whiB6_p.Met1? 2 start_lost (see "Genomic_coordinates" sheet) 1 3 0 3 3 98 3543 20674 0.000846023688663282 0.000174504417422474 0.00247043033885164 0.99528211053341 0.994253372218647 0.996168179073758 0.0297029702970297 0.00616785954356468 0.0843568982761224 0 0 0.707598226178713 0 0 0.0369419870351929 0 0 14.1254069624685 1 617 1879 False False 0.178627589901328 0.0362222534198973 0.538094231650217 0 0 0.00104063215855229 0.99528211053341 0.994253372218647 0.996168179073758 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 2 42 1605 6311 0.00124455507156191 0.000150756945780856 0.00448845844972244 0.993388950102314 0.991074178570735 0.995231303829434 0.0454545454545454 0.00555295199537049 0.154731577658989 0 0 0.841886116991581 0 0 0.0840838549403552 0 0 20.9517583246179 1 233 992 False False 0 0 0 0 0 0 0 0.187242248924491 0.0219370040116993 0.721194754383993 0 0 0.0022957280374523 0.993388950102314 0.991074178570735 0.995231303829434 195 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Met21_Asp46del whiB6_p.Met21_Asp46del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Met21Ile whiB6_p.Met21Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 227.625948755393 1 617 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 153.787547206498 1 233 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 5 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Met21Thr whiB6_p.Met21Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 20 3546 20752 0 0 0.0010397522169524 0.999037165414981 0.998513369831025 0.9994117795557 0 0 0.168433470983085 0 0 0.521823750104981 0 0 0.168433470983085 0 0 6.38899957191589 1 617 1879 False False 0 0 1.18605048536415 0 0 0.0010397522169524 0.999037165414981 0.998513369831025 0.9994117795557 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Phe5Cys whiB6_p.Phe5Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1656 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Phe5Ser whiB6_p.Phe5Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Phe90Leu whiB6_p.Phe90Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 3545 20770 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999903716541498 0.99965223478104 0.999988339413789 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 227.70085417967 1 193 1879 False False 2.92947813822284 0.0496406430315194 56.2247306595764 0 0 0.00104004536542481 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Phe90Ser whiB6_p.Phe90Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 3545 20770 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999903716541498 0.99965223478104 0.999988339413789 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 227.70085417967 1 193 1879 False False 2.92947813822284 0.0496406430315194 56.2247306595764 0 0 0.00104004536542481 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 905 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 4 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Phe90Val whiB6_p.Phe90Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 3545 20771 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999951858270749 0.999731800967312 0.999998781157685 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1688 1879 False False 5.8592383638928 0.0746220616644107 458.169367733398 0 0 0.00104004536542481 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Pro105fs whiB6_p.Pro105fs 2 frameshift (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 3546 20767 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 8.87492061244508 1 193 1879 False False 0 0 6.39361750002021 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.0580478247511 1 233 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Pro105Gln whiB6_p.Pro105Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 14.1776055911046 1 193 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 10 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Pro30Leu whiB6_p.Pro30Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1620 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 889 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Pro38Ala whiB6_p.Pro38Ala 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 9 30 3537 20742 0.00253807106598984 0.001161204060764 0.00481255792904073 0.998555748122472 0.99793887730437 0.99902536376823 0.23076923076923 0.111336941104146 0.393261540678467 NA NA NA 0 0 0.115703308222027 NA NA NA NA 1533 1879 False False 1.75928753180661 0.734047148402781 3.80494156331538 0 0 0.0010423965174912 0.998555748122472 0.99793887730437 0.99902536376823 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 8 1605 6345 0.00124455507156191 0.000150756945780856 0.00448845844972244 0.99874075240044 0.997520296036287 0.99945619445686 0.2 0.0252107263268333 0.556095462307641 NA NA NA 0 0 0.369416647552819 NA NA NA NA 833 992 False False 0 0 0 0 0 0 0 0.988317757009345 0.102140803317787 4.95892736625354 0 0 0.0022957280374523 0.99874075240044 0.997520296036287 0.99945619445686 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Pro38fs whiB6_p.Pro38fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Pro38Leu whiB6_p.Pro38Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 10 42 3536 20730 0.00282007896221094 0.00135314014136576 0.00518009078773565 0.997978047371461 0.997267879478758 0.998542377750177 0.192307692307692 0.0962675715521738 0.32534131471623 0 0 0.975 0 0 0.0840838549403552 0 0 227.840297617831 1 617 1879 False False 1.39584680025856 0.623891991268004 2.83034126512463 0 0 0.00104269115914271 0.997978047371461 0.997267879478758 0.998542377750177 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 848 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 16 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Pro38Ser whiB6_p.Pro38Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 31.2162477992404 1 193 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Pro45Ser whiB6_p.Pro45Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Pro57fs whiB6_p.Pro57fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1684 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Pro57Leu whiB6_p.Pro57Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 9 0 9 0 10 3546 20762 0 0 0.0010397522169524 0.99951858270749 0.999114835261082 0.999769118326375 0 0 0.30849710781876 0 0 0.336267116879942 0 0 0.30849710781876 0 0 2.96772171506905 0.374006764233317 105.5 1879 False False 0 0 2.61340113759526 0 0 0.0010397522169524 0.99951858270749 0.999114835261082 0.999769118326375 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Pro82Leu whiB6_p.Pro82Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Ser112fs whiB6_p.Ser112fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1592 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Ser112Phe whiB6_p.Ser112Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Ser115Ala whiB6_p.Ser115Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 9 0 9 0 12 3546 20760 0 0 0.0010397522169524 0.999422299248989 0.998991090727643 0.999701459098715 0 0 0.264648469397051 0 0 0.336267116879942 0 0 0.264648469397051 0 0 2.96743598417841 0.374001134918259 104 1879 False False 0 0 2.1081669380099 0 0 0.0010397522169524 0.999422299248989 0.998991090727643 0.999701459098715 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 153.76339448854 1 233 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 5 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Ser115fs whiB6_p.Ser115fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 3545 20771 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999951858270749 0.999731800967312 0.999998781157685 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 5.8592383638928 0.0746220616644107 458.169367733398 0.270378083801644 96 1879 False False 5.8592383638928 0.0746220616644107 458.169367733398 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Ser69Pro whiB6_p.Ser69Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Ser84fs whiB6_p.Ser84fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1685 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Ser84Leu whiB6_p.Ser84Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Ser97fs whiB6_p.Ser97fs 2 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1582 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Ser97Pro whiB6_p.Ser97Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 34 3544 20738 0.000564015792442188 6.83122290578968e-05 0.00203591855262226 0.998363181205468 0.997713453833747 0.998866197296832 0.0555555555555555 0.00680030065402281 0.186636706457554 NA NA NA 0 0 0.102817924259012 NA NA NA NA 1581 1879 False False 0.344210596202363 0.0400502571379294 1.34374167221195 0 0 0.0010403386792448 0.998363181205468 0.997713453833747 0.998866197296832 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 7 1606 6346 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.998898158350385 0.997731111129242 0.999556891392146 0.125 0.0031597235312519 0.526509670875206 NA NA NA 0 0 0.409616397225003 NA NA NA NA 866 992 False False 0 0 0 0 0 0 0 0.564490304216331 0.0125208374793046 4.39917903285694 0 0 0.00229430020901157 0.998898158350385 0.997731111129242 0.999556891392146 3 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Ter117Trpext*? whiB6_p.Ter117Trpext*? 2 stop_lost (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Thr10Ala whiB6_p.Thr10Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Thr11Ala whiB6_p.Thr11Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1568 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Thr11Pro whiB6_p.Thr11Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1644 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Thr22fs whiB6_p.Thr22fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1529 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 828 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Thr22Lys whiB6_p.Thr22Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1605 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 878 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Thr24Ala whiB6_p.Thr24Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 227.636869136849 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Thr24fs whiB6_p.Thr24fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 3545 20770 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999903716541498 0.99965223478104 0.999988339413789 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 227.70085417967 1 193 1879 False False 2.92947813822284 0.0496406430315194 56.2247306595764 0 0 0.00104004536542481 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 1606 6352 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.999842594050055 0.999123305664052 0.999996014834324 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 153.907242753895 1 233 992 False False 0 0 0 0 0 0 0 3.95516811955168 0.0503551805307198 309.72516523151 0 0 0.00229430020901157 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Thr35Met whiB6_p.Thr35Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Thr35Pro whiB6_p.Thr35Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Thr42Ala whiB6_p.Thr42Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Thr42Met whiB6_p.Thr42Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 227.625948755393 1 617 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Thr43Ala whiB6_p.Thr43Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 3542 20772 0.00112803158488437 0.000307433460438748 0.00288566784728404 1 0.99982242673208 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 1639 1879 False False Inf 3.86904162096631 Inf 0 0 0.00104092580348739 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Thr43Pro whiB6_p.Thr43Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 3545 20771 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999951858270749 0.999731800967312 0.999998781157685 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1667 1879 False False 5.8592383638928 0.0746220616644107 458.169367733398 0 0 0.00104004536542481 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Thr44del whiB6_p.Thr44del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Thr44fs whiB6_p.Thr44fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Thr44Ile whiB6_p.Thr44Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 31.21472012401 1 617 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 5 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Thr44Pro whiB6_p.Thr44Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 23 3546 20749 0 0 0.0010397522169524 0.998892740227229 0.998339027077604 0.999297966870435 0 0 0.148185128915224 0 0 0.975 0 0 0.148185128915224 0 0 227.407540340864 1 617 1879 False False 0 0 1.01853608279542 0 0 0.0010397522169524 0.998892740227229 0.998339027077604 0.999297966870435 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 153.787547206498 1 233 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 7 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Thr51Ala whiB6_p.Thr51Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Thr51fs whiB6_p.Thr51fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1640 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Thr51Pro whiB6_p.Thr51Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 561 671 2985 20101 0.158206429780033 0.146339494538808 0.170639726210903 0.967696899672636 0.965202056116725 0.970059695532848 0.455357142857142 0.427277886332941 0.483649935602067 0 0 0.975 0 0 0.00548250081433617 0 0 261.56986894547 1 617 1879 False False 5.63006837466018 4.99010877526675 6.34832333700013 0 0 0.00123504221909358 0.967696899672636 0.965202056116725 0.970059695532848 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 377 380 1230 5973 0.234598630989421 0.214069400526271 0.256101887925588 0.940185739020934 0.93407073974689 0.945892621436288 0.498018494055482 0.461807376400012 0.534245103246485 NA NA NA 0 0 0.00966061107988225 NA NA NA NA 829 992 False False 0 0 0 0 0 0 0 4.81775994865211 4.11139596104739 5.64292012330082 0 0 0.00299459621224107 0.940185739020934 0.93407073974689 0.945892621436288 709 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Trp16Arg whiB6_p.Trp16Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Trp16Cys whiB6_p.Trp16Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 14.1782880202046 1 617 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 3 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Trp16Ser whiB6_p.Trp16Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Trp16* whiB6_p.Trp16* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Trp41Cys whiB6_p.Trp41Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 3545 20770 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999903716541498 0.99965223478104 0.999988339413789 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 227.70085417967 1 193 1879 False False 2.92947813822284 0.0496406430315194 56.2247306595764 0 0 0.00104004536542481 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Trp41fs whiB6_p.Trp41fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 3545 20771 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999951858270749 0.999731800967312 0.999998781157685 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 5.8592383638928 0.0746220616644107 458.169367733398 0.270378083801644 96 1879 False False 5.8592383638928 0.0746220616644107 458.169367733398 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 2 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Trp41Ser whiB6_p.Trp41Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1586 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Trp41* whiB6_p.Trp41* 2 stop_gained (see "Genomic_coordinates" sheet) 1 4 0 4 1 9 3545 20763 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999566724436741 0.999177668076772 0.99980186029375 0.1 0.00252857854446178 0.445016117028195 0 0 0.602364635616474 0 0 0.336267116879942 0 0 8.87571500819164 1 617 1879 False False 0.650775740479548 0.0148464649376449 4.69895288822098 0 0 0.00104004536542481 0.999566724436741 0.999177668076772 0.99980186029375 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Trp60Arg whiB6_p.Trp60Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 227.636869136849 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 914 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Trp60fs whiB6_p.Trp60fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1673 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Trp60Ser whiB6_p.Trp60Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 14.1782880202046 1 617 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Trp60* whiB6_p.Trp60* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 5 3546 20767 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 0 0 0.521823750104981 0 0 0.975 0 0 0.521823750104981 0 0 227.60410798126 1 617 1879 False False 0 0 6.39361750002021 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Trp76Arg whiB6_p.Trp76Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1569 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Trp76Gly whiB6_p.Trp76Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 6 3545 20766 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999711149624494 0.999371401166804 0.999893989862555 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.841886116991581 0 0 0.4592581264399 0 0 31.2206153902525 1 617 1879 False False 0.976304654442877 0.0212191705766405 8.05133152464184 0 0 0.00104004536542481 0.999711149624494 0.999371401166804 0.999893989862555 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 21.0547398420152 1 233 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Trp76Ser whiB6_p.Trp76Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1554 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Trp76* whiB6_p.Trp76* 2 stop_gained (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 3545 20769 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999855574812247 0.999577986903419 0.999970215063798 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 14.1822872771732 1 617 1879 False False 1.95289139633286 0.0371893922070044 24.3461286113284 0 0 0.00104004536542481 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 1606 6352 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.999842594050055 0.999123305664052 0.999996014834324 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 153.907242753895 1 233 992 False False 0 0 0 0 0 0 0 3.95516811955168 0.0503551805307198 309.72516523151 0 0 0.00229430020901157 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Tyr104fs whiB6_p.Tyr104fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 3543 20772 0.000846023688663282 0.000174504417422474 0.00247043033885164 1 0.99982242673208 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1660 1879 False False Inf 2.42140315163361 Inf 0 0 0.00104063215855229 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 1605 6353 0.00124455507156191 0.000150756945780856 0.00448845844972244 1 0.999419516970794 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 918 992 False False 0 0 0 0 0 0 0 Inf 0.742689158362403 Inf 0 0 0.0022957280374523 1 0.999419516970794 1 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Tyr104His whiB6_p.Tyr104His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Tyr27fs whiB6_p.Tyr27fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Tyr27Ser whiB6_p.Tyr27Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1606 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 879 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 2 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Tyr27* whiB6_p.Tyr27* 2 stop_gained (see "Genomic_coordinates" sheet) 1 15 0 15 0 23 3546 20749 0 0 0.0010397522169524 0.998892740227229 0.998339027077604 0.999297966870435 0 0 0.148185128915224 0 0 0.218019360910534 0 0 0.148185128915224 0 0 1.63228836347644 0.149531490746469 74 1879 False False 0 0 1.01853608279542 0 0 0.0010397522169524 0.998892740227229 0.998339027077604 0.999297966870435 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 153.76339448854 1 233 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 37 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Tyr3Cys whiB6_p.Tyr3Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 10 1 9 1 9 3545 20763 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999566724436741 0.999177668076772 0.99980186029375 0.1 0.00252857854446178 0.445016117028195 0.1 0.00252857854446178 0.445016117028195 0.1 0.00252857854446178 0.445016117028195 0.650775740479548 0.0148464649376449 4.69895288822098 1 193 1879 False False 0.650775740479548 0.0148464649376449 4.69895288822098 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999566724436741 0.999177668076772 0.99980186029375 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 1 6 1 6 1606 6347 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.99905556430033 0.997945503023207 0.999653332387469 0.142857142857142 0.00361029686190058 0.578723197043195 0.142857142857142 0.00361029686190058 0.578723197043195 0.142857142857142 0.00361029686190058 0.578723197043195 0.658675799086758 0.0143145764136424 5.43586332883977 1 233 992 False False 0 0 0 0 0 0 0 0.658675799086758 0.0143145764136424 5.43586332883977 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.99905556430033 0.997945503023207 0.999653332387469 5 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Tyr3Ser whiB6_p.Tyr3Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1546 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Val106fs whiB6_p.Val106fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Val106Met whiB6_p.Val106Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Val111Ala whiB6_p.Val111Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1570 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 857 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Val111fs whiB6_p.Val111fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1675 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Val23Ala whiB6_p.Val23Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Val23Gly whiB6_p.Val23Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 20 3546 20752 0 0 0.0010397522169524 0.999037165414981 0.998513369831025 0.9994117795557 0 0 0.168433470983085 NA NA NA 0 0 0.168433470983085 NA NA NA NA 1547 1879 False False 0 0 1.18605048536415 0 0 0.0010397522169524 0.999037165414981 0.998513369831025 0.9994117795557 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 841 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 4 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Val33Asp whiB6_p.Val33Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Val33Gly whiB6_p.Val33Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 3546 20768 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1676 1879 False False 0 0 8.87534793394977 0 0 0.0010397522169524 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 925 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 8 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Val67fs whiB6_p.Val67fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 5 3546 20767 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1593 1879 False False 0 0 6.39361750002021 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Val79Ala whiB6_p.Val79Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 14 3546 20758 0 0 0.0010397522169524 0.999326015790487 0.998869427329123 0.999631479131688 0 0 0.231635761650116 NA NA NA 0 0 0.231635761650116 NA NA NA NA 1634 1879 False False 0 0 1.76565880831751 0 0 0.0010397522169524 0.999326015790487 0.998869427329123 0.999631479131688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 7 1607 6346 0 0 0.0022928741555424 0.998898158350385 0.997731111129242 0.999556891392146 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 896 992 False False 0 0 0 0 0 0 0 0 0 2.74289259224573 0 0 0.0022928741555424 0.998898158350385 0.997731111129242 0.999556891392146 4 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Val79fs whiB6_p.Val79fs 2 frameshift (see "Genomic_coordinates" sheet) 1 4 0 4 8 28 3538 20744 0.00225606316976875 0.000974495421506219 0.00444047881800877 0.998652031580974 0.998052395066333 0.999104103702576 0.222222222222222 0.101150530344912 0.391517649157381 0 0 0.602364635616474 0 0 0.123436118500263 0 0 8.88514294676915 1 617 1879 False False 1.6751998707906 0.659241361388419 3.7763338668675 0 0 0.00104210204231118 0.998652031580974 0.998052395066333 0.999104103702576 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 4 1604 6349 0.00186683260734287 0.000385151348909821 0.00544589495836224 0.99937037620022 0.998388704765699 0.99982842290899 0.428571428571428 0.0989882784425078 0.815948432359917 0 0 0.975 0 0 0.602364635616474 0 0 154.026091959337 1 233 992 False False 0 0 0 0 0 0 0 2.96867206982543 0.434359218125022 17.5617612770521 0 0 0.00229715764418053 0.99937037620022 0.998388704765699 0.99982842290899 18 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Val79Gly whiB6_p.Val79Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 9 3546 20763 0 0 0.0010397522169524 0.999566724436741 0.999177668076772 0.99980186029375 0 0 0.336267116879942 0 0 0.975 0 0 0.336267116879942 0 0 227.560426388115 1 617 1879 False False 0 0 2.96786458045639 0 0 0.0010397522169524 0.999566724436741 0.999177668076772 0.99980186029375 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 923 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 12 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Val80fs whiB6_p.Val80fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB6 p.Val80Gly whiB6_p.Val80Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1630 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB7 c.-100T>C whiB7_c.-100T>C 1 upstream_gene_variant 3568779 1 229 2 227 7 245 3539 20527 0.00197405527354765 0.000794029400507555 0.00406305244102797 0.988205276333526 0.98664270044313 0.98962887973769 0.0277777777777777 0.0112395150998231 0.0563928527210561 0.00873362445414847 0.00105943798413982 0.0311909998607441 0.00809716599190283 0.000982113017694561 0.0289420221140634 0.0511033132383896 0.00615659490867109 0.186935324177047 2.45111867517817e-13 NA NA False True 0.165720744358777 0.0659047690952852 0.347066287321554 0.000564812199943518 6.84086983332825e-05 0.00203879121086904 0.988205276333526 0.98664270044313 0.98962887973769 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 72 0 72 1 80 1606 6273 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.987407524004407 0.984351757689526 0.990002667944162 0.0123456790123456 0.000312516687153829 0.0668756209322107 0 0 0.0499440837058546 0 0 0.0450640350676923 0 0 0.205675772859742 1.37718695662284e-07 NA NA False True 1 1 1 0 0 1 0 0.0488247198007472 0.001224508383419 0.280456550605297 0 0 0.00229430020901157 0.987407524004407 0.984351757689526 0.990002667944162 181 Not assoc w R 5) Not assoc w R No change yes 1 +Kanamycin whiB7 c.-103G>C whiB7_c.-103G>C 1 upstream_gene_variant 3568782 0 0 0 0 4 3 3542 20769 0.00112803158488437 0.000307433460438748 0.00288566784728404 0.999855574812247 0.999577986903419 0.999970215063798 0.571428571428571 0.184051567640083 0.901011721557492 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1494 1879 False False 7.81818181818181 1.32190864669878 53.4004081503056 0 0 0.00104092580348739 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 2 1 1 3 1 1604 6352 0.00186683260734287 0.000385151348909821 0.00544589495836224 0.999842594050055 0.999123305664052 0.999996014834324 0.75 0.194120449683243 0.99369053679029 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 3.96009975062344 0.0504179288019786 310.110293222452 0.362711543634747 52 992 False False 0 0 0 0 0 0 0 11.8802992518703 0.952813669419898 621.430040107933 0.000623052959501557 1.57742107785327e-05 0.00346648897061963 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB7 c.-116A>G whiB7_c.-116A>G 1 upstream_gene_variant 3568795 1 128 21 107 50 118 3496 20654 0.0141003948110547 0.0104832135542523 0.0185478071504463 0.994319275948392 0.993200840033492 0.995295723036923 0.297619047619047 0.229649562845095 0.372885797191279 0.1640625 0.104520098247778 0.23978761895874 0.151079136690647 0.0960192513065513 0.221622905064342 1.15949335956714 0.688596928139395 1.86657845378636 0.528770111808758 128 1879 False False 2.50334522747546 1.75767314059818 3.52021582556252 0.00597099800966733 0.00369982869940167 0.00911289535611192 0.994319275948392 0.993200840033492 0.995295723036923 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 52 17 35 29 37 1578 6316 0.0180460485376477 0.0121181898188003 0.0258149673465609 0.994175979852038 0.991981206147111 0.995896135055164 0.439393939393939 0.31736586376925 0.56703880329704 0.326923076923076 0.203297787819103 0.471053239452452 0.314814814814814 0.195239411003191 0.455523994872843 1.94408835777657 1.01843134600019 3.57494456349843 0.0349547744341597 20 992 False False 0 0 0 0 0 0 0 3.13712191278731 1.8542601544942 5.25929990159976 0.0106583072100313 0.00622077177482857 0.0170102976613416 0.994175979852038 0.991981206147111 0.995896135055164 38 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-121C>T whiB7_c.-121C>T 1 upstream_gene_variant 3568800 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-124G>A whiB7_c.-124G>A 1 upstream_gene_variant 3568803 1 1 0 1 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 227.636869136849 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-128A>G whiB7_c.-128A>G 1 upstream_gene_variant 3568807 0 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1521 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-140C>G whiB7_c.-140C>G 1 upstream_gene_variant 3568819 1 3 0 3 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 14.1782880202046 1 617 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.0580478247511 1 233 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-151T>A whiB7_c.-151T>A 1 upstream_gene_variant 3568830 1 3 0 3 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 14.1782880202046 1 617 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-154C>T whiB7_c.-154C>T 1 upstream_gene_variant 3568833 1 3 3 0 4 1 3542 20771 0.00112803158488437 0.000307433460438748 0.00288566784728404 0.999951858270749 0.999731800967312 0.999998781157685 0.8 0.28358206388191 0.994949236620532 1 0.292401773821286 1 0.75 0.194120449683243 0.99369053679029 Inf 2.42196976538259 Inf 0.00309640873609666 24 1879 False False 23.4568040654997 2.31983502871961 1147.30025849051 0.000846262341325811 0.000174553652523219 0.00247112664931444 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 1 1605 6352 0.00124455507156191 0.000150756945780856 0.00448845844972244 0.999842594050055 0.999123305664052 0.999996014834324 0.666666666666666 0.0942993240502461 0.991596241340387 1 0.158113883008419 1 0.666666666666666 0.0942993240502461 0.991596241340387 Inf 0.742572245303751 Inf 0.0407473132677553 23 992 False False 0 0 0 0 0 0 0 7.91526479750778 0.41169480990745 465.597805007535 0.00124455507156191 0.000150756945780856 0.00448845844972244 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.15A>C whiB7_c.15A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.2177754884198 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin whiB7 c.-161A>G whiB7_c.-161A>G 1 upstream_gene_variant 3568840 1 5 1 4 1 4 3545 20768 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999807433082996 0.99950702628237 0.999947529583666 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 1.46459802538787 0.0297312351170663 14.8120229375093 0.545303294278226 129 1879 False False 1.46459802538787 0.0297312351170663 14.8120229375093 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999807433082996 0.99950702628237 0.999947529583666 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 6 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-163C>G whiB7_c.-163C>G 1 upstream_gene_variant 3568842 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-166delG whiB7_c.-166delG 1 upstream_gene_variant 3568844 1 3 0 3 1 3 3545 20769 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999855574812247 0.999577986903419 0.999970215063798 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 14.1822872771732 1 617 1879 False False 1.95289139633286 0.0371893922070044 24.3461286113284 0 0 0.00104004536542481 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 1606 6352 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.999842594050055 0.999123305664052 0.999996014834324 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 153.907242753895 1 233 992 False False 0 0 0 0 0 0 0 3.95516811955168 0.0503551805307198 309.72516523151 0 0 0.00229430020901157 0.999842594050055 0.999123305664052 0.999996014834324 2 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-166G>A whiB7_c.-166G>A 1 upstream_gene_variant 3568845 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-172A>G whiB7_c.-172A>G 1 upstream_gene_variant 3568851 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-176delG whiB7_c.-176delG 1 upstream_gene_variant 3568854 1 5 2 3 36 123 3510 20649 0.0101522842639593 0.00712038177541555 0.0140275832643025 0.994078567302137 0.992938936551678 0.995076363650856 0.226415094339622 0.163898196624317 0.299414597097939 0.4 0.0527449505263169 0.853367200365326 0.016 0.00194358180236891 0.0566021196197549 3.92193732193732 0.327433701706016 34.2395227165544 0.156253096104017 80 1879 False False 1.72182614133833 1.15113040467862 2.51925636189569 0.000569476082004555 6.89736374979231e-05 0.0020556138094176 0.994078567302137 0.992938936551678 0.995076363650856 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 6 18 1601 6335 0.00373366521468575 0.00137138406067734 0.00810877842801138 0.997166692900991 0.995525835694433 0.998319964918202 0.25 0.097730409474533 0.467112802422669 NA NA NA 0 0 0.185301968137852 NA NA NA NA 802 992 False False 0 0 0 0 0 0 0 1.3189673120966 0.427849349449831 3.47533391639568 0 0 0.00230145716737395 0.997166692900991 0.995525835694433 0.998319964918202 4 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.177G>T whiB7_c.177G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA 208 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin whiB7 c.-178C>T whiB7_c.-178C>T 1 upstream_gene_variant 3568857 1 92 1 91 4 115 3542 20657 0.00112803158488437 0.000307433460438748 0.00288566784728404 0.994463701136144 0.993358200822814 0.995427117303304 0.0336134453781512 0.00923307244664729 0.0838290092495051 0.0108695652173913 0.000275155702770738 0.0590778511498147 0.00862068965517241 0.000218233149063064 0.0470955362266474 0.0640880858272162 0.00160873947864678 0.366436679599477 1.82509328264e-05 NA NA False True 0.20285272383571 0.0542950085943435 0.534171933190126 0.000282246683601467 7.14584180797538e-06 0.00157156367129611 0.994463701136144 0.993358200822814 0.995427117303304 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 7 0 7 1 13 1606 6340 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.997953722650716 0.996503345413809 0.998910007694291 0.0714285714285714 0.00180678065912538 0.338684489931821 0 0 0.409616397225003 0 0 0.24705263800047 0 0 2.74200785203754 0.357342932675165 NA NA False True 0 0 0 0 0 1 0 0.30366893380592 0.00714464649823022 2.02468686659141 0 0 0.00229430020901157 0.997953722650716 0.996503345413809 0.998910007694291 138 Not assoc w R Previous WHO guidance 4) Not assoc w R - Interim DOWN from NotAwR to NotAwRI yes Prev. WHO 3 +Kanamycin whiB7 c.180T>G whiB7_c.180T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 3545 20771 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999951858270749 0.999731800967312 0.999998781157685 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 5.8592383638928 0.0746220616644107 458.169367733398 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin whiB7 c.186C>G whiB7_c.186C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin whiB7 c.18C>A whiB7_c.18C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 8 3546 20764 0 0 0.0010397522169524 0.999614866165992 0.999241274614236 0.99983371235125 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.43205141622579 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin whiB7 c.18C>T whiB7_c.18C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 14.1782880202046 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 153.811699906182 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin whiB7 c.-195C>T whiB7_c.-195C>T 1 upstream_gene_variant 3568874 1 21 0 21 0 23 3546 20749 0 0 0.0010397522169524 0.998892740227229 0.998339027077604 0.999297966870435 0 0 0.148185128915224 0 0 0.161097615219079 0 0 0.148185128915224 0 0 1.12430502232422 0.0613626582530707 36 1879 False False 0 0 1.01853608279542 0 0 0.0010397522169524 0.998892740227229 0.998339027077604 0.999297966870435 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 1607 6349 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.56934488045651 1 86 992 False False 0 0 0 0 0 0 0 0 0 5.99028746746614 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 1 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-200G>T whiB7_c.-200G>T 1 upstream_gene_variant 3568879 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-203_-202insC whiB7_c.-203_-202insC 1 upstream_gene_variant 3568881 1 2 1 1 1 1 3545 20771 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999951858270749 0.999731800967312 0.999998781157685 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 5.8592383638928 0.0746220616644107 458.169367733398 0.270378083801644 96 1879 False False 5.8592383638928 0.0746220616644107 458.169367733398 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-203_-202insCC whiB7_c.-203_-202insCC 1 upstream_gene_variant 3568881 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB7 c.-205_-204insA whiB7_c.-205_-204insA 1 upstream_gene_variant 3568883 1 4 1 3 1 3 3545 20769 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999855574812247 0.999577986903419 0.999970215063798 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 1.95289139633286 0.0371893922070044 24.3461286113284 0.467666809374076 123.5 1879 False False 1.95289139633286 0.0371893922070044 24.3461286113284 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-212A>C whiB7_c.-212A>C 1 upstream_gene_variant 3568891 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-214_-213insA whiB7_c.-214_-213insA 1 upstream_gene_variant 3568892 0 0 0 0 3 1 3543 20771 0.000846023688663282 0.000174504417422474 0.00247043033885164 0.999951858270749 0.999731800967312 0.999998781157685 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 1491 1879 False False 17.5876375952582 1.41144968084872 918.001314114865 0 0 0.00104063215855229 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 1604 6353 0.00186683260734287 0.000385151348909821 0.00544589495836224 1 0.999419516970794 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 801 992 False False 0 0 0 0 0 0 0 Inf 1.63477030328606 Inf 0 0 0.00229715764418053 1 0.999419516970794 1 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB7 c.-214A>C whiB7_c.-214A>C 1 upstream_gene_variant 3568893 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.0580478247511 1 233 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 4 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB7 c.-215_-214delCA whiB7_c.-215_-214delCA 1 upstream_gene_variant 3568892 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB7 c.-215delC whiB7_c.-215delC 1 upstream_gene_variant 3568893 1 7 4 3 8 10 3538 20762 0.00225606316976875 0.000974495421506219 0.00444047881800877 0.99951858270749 0.999114835261082 0.999769118326375 0.444444444444444 0.215301507387299 0.692428341001244 0.571428571428571 0.184051567640083 0.901011721557492 0.285714285714285 0.0838893183071275 0.581035257183661 7.82438289052195 1.32295559408825 53.4429858670776 0.0108925058943127 29 1879 False False 4.69462973431317 1.60876714405521 13.2220938919982 0.00112930547713155 0.000307780740406945 0.00288892377591315 0.99951858270749 0.999114835261082 0.999769118326375 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 2 0 2 1 2 1606 6351 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.99968518810011 0.99886325869706 0.999961872544366 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.0711357948012 1 233 992 False False 0 0 0 0 0 0 0 1.97727272727272 0.0334940093351611 38.0316888278718 0 0 0.00229430020901157 0.99968518810011 0.99886325869706 0.999961872544366 10 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB7 c.-217C>G whiB7_c.-217C>G 1 upstream_gene_variant 3568896 2 1 1 0 4 0 3542 20772 0.00112803158488437 0.000307433460438748 0.00288566784728404 1 0.99982242673208 1 1 0.397635364383525 1 1 0.025 1 1 0.025 1 Inf 0.15032887904429 Inf 0.145712523133868 45.5 1879 False False Inf 3.86904162096631 Inf 0.000282246683601467 7.14584180797538e-06 0.00157156367129611 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 2 0 1605 6353 0.00124455507156191 0.000150756945780856 0.00448845844972244 1 0.999419516970794 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.101430455199151 Inf 0.20178414373665 31.5 992 False False 0 0 0 0 0 0 0 Inf 0.742689158362403 Inf 0.00062266500622665 1.57643888068998e-05 0.00346433358074439 1 0.999419516970794 1 5 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB7 c.-221A>C whiB7_c.-221A>C 1 upstream_gene_variant 3568900 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1499 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 805 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-221delA whiB7_c.-221delA 1 upstream_gene_variant 3568899 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1495 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-227G>C whiB7_c.-227G>C 1 upstream_gene_variant 3568906 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-235T>C whiB7_c.-235T>C 1 upstream_gene_variant 3568914 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1490 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-23C>A whiB7_c.-23C>A 1 upstream_gene_variant 3568702 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1519 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-240C>G whiB7_c.-240C>G 1 upstream_gene_variant 3568919 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 21.0580478247511 1 233 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-242G>C whiB7_c.-242G>C 1 upstream_gene_variant 3568921 1 54 2 52 6 69 3540 20703 0.00169204737732656 0.000621196730345483 0.00367920983862615 0.996678220681686 0.995797930849965 0.997414565949285 0.08 0.0299251447340774 0.166036871298822 0.037037037037037 0.00451725629446049 0.127471772230947 0.028169014084507 0.00342979077123614 0.0980800686570548 0.22493481095176 0.026499990758436 0.855121471570129 0.0191056579649262 32 1879 False False 0.508548268238762 0.180277282466926 1.1656306628588 0.000564652738565782 6.83893826872173e-05 0.00203821603087665 0.996678220681686 0.995797930849965 0.997414565949285 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 19 0 19 2 29 1605 6324 0.00124455507156191 0.000150756945780856 0.00448845844972244 0.995435227451597 0.993450754193271 0.996940832844943 0.064516129032258 0.0079109834618547 0.214216157163402 0 0 0.176466911806965 0 0 0.119444869069502 0 0 0.845486318185708 0.0207340967373747 18 992 False False 0 0 0 0 0 0 0 0.27173702868192 0.0313970867467516 1.07614843667317 0 0 0.0022957280374523 0.995435227451597 0.993450754193271 0.996940832844943 89 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-24A>G whiB7_c.-24A>G 1 upstream_gene_variant 3568703 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-250G>A whiB7_c.-250G>A 1 upstream_gene_variant 3568929 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1506 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-257G>A whiB7_c.-257G>A 1 upstream_gene_variant 3568936 1 2 1 1 1 1 3545 20771 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999951858270749 0.999731800967312 0.999998781157685 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 5.8592383638928 0.0746220616644107 458.169367733398 0.270378083801644 96 1879 False False 5.8592383638928 0.0746220616644107 458.169367733398 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-258T>G whiB7_c.-258T>G 1 upstream_gene_variant 3568937 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-26A>C whiB7_c.-26A>C 1 upstream_gene_variant 3568705 0 0 0 0 1 2 3545 20770 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999903716541498 0.99965223478104 0.999988339413789 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1525 1879 False False 2.92947813822284 0.0496406430315194 56.2247306595764 0 0 0.00104004536542481 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 825 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 2 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB7 c.-278G>C whiB7_c.-278G>C 1 upstream_gene_variant 3568957 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-279G>T whiB7_c.-279G>T 1 upstream_gene_variant 3568958 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB7 c.-282C>T whiB7_c.-282C>T 1 upstream_gene_variant 3568961 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB7 c.-289G>A whiB7_c.-289G>A 1 upstream_gene_variant 3568968 1 2 0 2 0 5 3546 20767 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 0 0 0.521823750104981 0 0 0.841886116991581 0 0 0.521823750104981 0 0 31.2131924627285 1 617 1879 False False 0 0 6.39361750002021 0 0 0.0010397522169524 0.999759291353745 0.999438356476751 0.999921838086342 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 813 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-295A>C whiB7_c.-295A>C 1 upstream_gene_variant 3568974 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-305_-304insG whiB7_c.-305_-304insG 1 upstream_gene_variant 3568983 0 0 0 0 2 0 3544 20772 0.000564015792442188 6.83122290578968e-05 0.00203591855262226 1 0.99982242673208 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1501 1879 False False Inf 1.10031452590981 Inf 0 0 0.0010403386792448 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB7 c.-307_-306insGG whiB7_c.-307_-306insGG 1 upstream_gene_variant 3568985 1 8 0 8 0 8 3546 20764 0 0 0.0010397522169524 0.999614866165992 0.999241274614236 0.99983371235125 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 3.43205141622579 0.612907213659498 156 1879 False False 0 0 3.43205141622579 0 0 0.0010397522169524 0.999614866165992 0.999241274614236 0.99983371235125 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 1607 6349 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.99028746746614 0.589339945669686 68 992 False False 0 0 0 0 0 0 0 0 0 5.99028746746614 0 0 0.0022928741555424 0.99937037620022 0.998388704765699 0.99982842290899 6 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-317_-316insG whiB7_c.-317_-316insG 1 upstream_gene_variant 3568995 1 4 1 3 1 3 3545 20769 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999855574812247 0.999577986903419 0.999970215063798 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 1.95289139633286 0.0371893922070044 24.3461286113284 0.467666809374076 123.5 1879 False False 1.95289139633286 0.0371893922070044 24.3461286113284 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 2 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-318_-317delGG whiB7_c.-318_-317delGG 1 upstream_gene_variant 3568995 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB7 c.-31C>T whiB7_c.-31C>T 1 upstream_gene_variant 3568710 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-321G>C whiB7_c.-321G>C 1 upstream_gene_variant 3569000 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-322G>C whiB7_c.-322G>C 1 upstream_gene_variant 3569001 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-328G>A whiB7_c.-328G>A 1 upstream_gene_variant 3569007 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-32G>A whiB7_c.-32G>A 1 upstream_gene_variant 3568711 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-338G>T whiB7_c.-338G>T 1 upstream_gene_variant 3569017 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB7 c.-340delC whiB7_c.-340delC 1 upstream_gene_variant 3569018 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1522 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-341C>A whiB7_c.-341C>A 1 upstream_gene_variant 3569020 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-34C>T whiB7_c.-34C>T 1 upstream_gene_variant 3568713 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-350A>G whiB7_c.-350A>G 1 upstream_gene_variant 3569029 1 53 0 53 1 86 3545 20686 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.995859811284421 0.994889389598224 0.996687089477825 0.0114942528735632 0.000290966948080257 0.0623843202541672 0 0 0.0672345463063011 0 0 0.0419870153041445 0 0 0.420849157760744 0.000561974536391279 19 1879 False True 0.067851871289402 0.00170189734511692 0.388550350962918 0 0 0.00104004536542481 0.995859811284421 0.994889389598224 0.996687089477825 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 49 0 49 1 71 1606 6282 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.988824177553911 0.985923844338686 0.991261559261911 0.0138888888888888 0.000351574405233597 0.0749713108539191 0 0 0.0725192636642774 0 0 0.0506294079544037 0 0 0.306337929653393 2.09482944093399e-05 8 992 True True 1 1 1 0 0 0 0 0.0550926981565607 0.00137899262101423 0.317614780123302 0 0 0.00229430020901157 0.988824177553911 0.985923844338686 0.991261559261911 96 5) Not assoc w R UP from Uncertain to NotAwR yes 4 +Kanamycin whiB7 c.-351C>T whiB7_c.-351C>T 1 upstream_gene_variant 3569030 1 1 1 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.150201697158088 Inf 0.14581791265729 60 1879 False False Inf 0.150201697158088 Inf 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB7 c.-353C>A whiB7_c.-353C>A 1 upstream_gene_variant 3569032 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 3 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-355G>A whiB7_c.-355G>A 1 upstream_gene_variant 3569034 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-358C>T whiB7_c.-358C>T 1 upstream_gene_variant 3569037 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1496 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-360T>C whiB7_c.-360T>C 1 upstream_gene_variant 3569039 1 2 0 2 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 31.2162477992404 1 193 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-371_-361delACCGGTTAACC whiB7_c.-371_-361delACCGGTTAACC 1 upstream_gene_variant 3569039 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1518 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-375T>C whiB7_c.-375T>C 1 upstream_gene_variant 3569054 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-37G>A whiB7_c.-37G>A 1 upstream_gene_variant 3568716 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB7 c.-386T>C whiB7_c.-386T>C 1 upstream_gene_variant 3569065 1 23 1 22 7 30 3539 20742 0.00197405527354765 0.000794029400507555 0.00406305244102797 0.998555748122472 0.99793887730437 0.99902536376823 0.189189189189189 0.0796211208528768 0.351552378369254 0.0434782608695652 0.0011001686304415 0.21948660745348 0.032258064516129 0.000816370071846613 0.167021116230227 0.266408076241362 0.00645673514609808 1.64927585650061 0.238123832042239 85 1879 False False 1.36756145803899 0.506627125757424 3.18083392804643 0.000282485875706214 7.15189758446245e-06 0.00157289464501599 0.998555748122472 0.99793887730437 0.99902536376823 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 1 8 1606 6345 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.99874075240044 0.997520296036287 0.99945619445686 0.111111111111111 0.00280913674659921 0.482496514917337 0 0 0.409616397225003 0 0 0.369416647552819 0 0 2.74416932025654 0.357352266880582 50 992 False False 0 0 0 0 0 0 0 0.493851183063511 0.0111262820523154 3.6883573216039 0 0 0.00229430020901157 0.99874075240044 0.997520296036287 0.99945619445686 53 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-390G>T whiB7_c.-390G>T 1 upstream_gene_variant 3569069 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-392C>T whiB7_c.-392C>T 1 upstream_gene_variant 3569071 1 2 1 1 1 1 3545 20771 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999951858270749 0.999731800967312 0.999998781157685 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 5.8592383638928 0.0746220616644107 458.169367733398 0.270378083801644 96 1879 False False 5.8592383638928 0.0746220616644107 458.169367733398 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-396A>G whiB7_c.-396A>G 1 upstream_gene_variant 3569075 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-401T>G whiB7_c.-401T>G 1 upstream_gene_variant 3569080 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.48G>A whiB7_c.48G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin whiB7 c.-49A>G whiB7_c.-49A>G 1 upstream_gene_variant 3568728 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-50G>A whiB7_c.-50G>A 1 upstream_gene_variant 3568729 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-51G>C whiB7_c.-51G>C 1 upstream_gene_variant 3568730 1 2 1 1 1 1 3545 20771 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999951858270749 0.999731800967312 0.999998781157685 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 5.8592383638928 0.0746220616644107 458.169367733398 0.270378083801644 96 1879 False False 5.8592383638928 0.0746220616644107 458.169367733398 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 1606 6352 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.999842594050055 0.999123305664052 0.999996014834324 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 3.95516811955168 0.0503551805307198 309.72516523151 0.363031768971759 54 992 False False 0 0 0 0 0 0 0 3.95516811955168 0.0503551805307198 309.72516523151 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB7 c.-53C>T whiB7_c.-53C>T 1 upstream_gene_variant 3568732 1 19 0 19 0 22 3546 20750 0 0 0.0010397522169524 0.99894088195648 0.998396919060608 0.999336141078939 0 0 0.154372512815574 0 0 0.176466911806965 0 0 0.154372512815574 0 0 1.25463661230274 0.0976130618701204 42 1879 False False 0 0 1.06886653935238 0 0 0.0010397522169524 0.99894088195648 0.998396919060608 0.999336141078939 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 1607 6350 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 153.76339448854 1 233 992 False False 0 0 0 0 0 0 0 0 0 9.57085126512166 0 0 0.0022928741555424 0.999527782150165 0.998620605323549 0.999902606737868 16 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-55delG whiB7_c.-55delG 1 upstream_gene_variant 3568733 1 2 2 0 2 0 3544 20772 0.000564015792442188 6.83122290578968e-05 0.00203591855262226 1 0.99982242673208 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 1.10031452590981 Inf 0.0212577415129373 34 1879 False False Inf 1.10031452590981 Inf 0.000564015792442188 6.83122290578968e-05 0.00203591855262226 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-55G>A whiB7_c.-55G>A 1 upstream_gene_variant 3568734 1 10 5 5 5 5 3541 20767 0.00141003948110547 0.000457989490992675 0.00328746875206548 0.999759291353745 0.999438356476751 0.999921838086342 0.5 0.187086028447398 0.812913971552601 0.5 0.187086028447398 0.812913971552601 0.5 0.187086028447398 0.812913971552601 5.86472747811352 1.34887603073477 25.4914975654025 0.00872671800701302 27 1879 False False 5.86472747811352 1.34887603073477 25.4914975654025 0.00141003948110547 0.000457989490992675 0.00328746875206548 0.999759291353745 0.999438356476751 0.999921838086342 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 1 2 1606 6351 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.99968518810011 0.99886325869706 0.999961872544366 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 1.97727272727272 0.0334940093351611 38.0316888278718 0.491658050356828 61 992 False False 0 0 0 0 0 0 0 1.97727272727272 0.0334940093351611 38.0316888278718 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.99968518810011 0.99886325869706 0.999961872544366 3 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-55G>T whiB7_c.-55G>T 1 upstream_gene_variant 3568734 1 4 1 3 1 3 3545 20769 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999855574812247 0.999577986903419 0.999970215063798 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 1.95289139633286 0.0371893922070044 24.3461286113284 0.467666809374076 123.5 1879 False False 1.95289139633286 0.0371893922070044 24.3461286113284 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 1 3 1 3 1606 6350 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.999527782150165 0.998620605323549 0.999902606737868 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 1.31797426317974 0.0250900413291082 16.4244635399174 1 233 992 False False 0 0 0 0 0 0 0 1.31797426317974 0.0250900413291082 16.4244635399174 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.999527782150165 0.998620605323549 0.999902606737868 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB7 c.-56G>A whiB7_c.-56G>A 1 upstream_gene_variant 3568735 1 3 1 2 2 2 3544 20770 0.000564015792442188 6.83122290578968e-05 0.00203591855262226 0.999903716541498 0.99965223478104 0.999988339413789 0.5 0.067585986488543 0.932414013511457 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 2.93030474040632 0.0496546460862066 56.2404616661481 0.376701886001193 113 1879 False False 5.86060948081264 0.424646188620106 80.7055921553874 0.000282087447108603 7.14181031782542e-06 0.001570677606179 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 806 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 3 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-56G>T whiB7_c.-56G>T 1 upstream_gene_variant 3568735 1 1 1 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.150201697158088 Inf 0.14581791265729 60 1879 False False Inf 0.150201697158088 Inf 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-57delT whiB7_c.-57delT 1 upstream_gene_variant 3568735 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-57T>C whiB7_c.-57T>C 1 upstream_gene_variant 3568736 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB7 c.-57T>G whiB7_c.-57T>G 1 upstream_gene_variant 3568736 1 48 3 45 12 50 3534 20722 0.00338409475465313 0.00174979607500839 0.00590386326830579 0.997592913537454 0.996827772968939 0.99821290233095 0.193548387096774 0.104209629262176 0.313685951699462 0.0625 0.0130792444095526 0.17195993079057 0.0566037735849056 0.0118287188591336 0.156629462172374 0.390907375966798 0.0776643124109282 1.21878521744399 0.147390105631894 73 1879 False False 1.40726655348047 0.681411446284686 2.68331190454778 0.000848176420695504 0.000174948535766237 0.0024767112957132 0.997592913537454 0.996827772968939 0.99821290233095 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 22 0 22 5 25 1602 6328 0.00311138767890479 0.00101100708660053 0.00724588638281331 0.996064851251377 0.994196388644299 0.997451809359823 0.166666666666666 0.0564216964680715 0.347211698834143 0 0 0.154372512815574 0 0 0.137185171530712 0 0 0.722116045421895 0.0134451207370828 17 992 False False 0 0 0 0 0 0 0 0.790012484394506 0.235827541995262 2.10560448730647 0 0 0.00230002220580469 0.996064851251377 0.994196388644299 0.997451809359823 15 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.60C>T whiB7_c.60C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 31.2177754884198 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin whiB7 c.-65A>G whiB7_c.-65A>G 1 upstream_gene_variant 3568744 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1516 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 819 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-66C>G whiB7_c.-66C>G 1 upstream_gene_variant 3568745 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1497 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 804 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.66C>T whiB7_c.66C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 227.647789514565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Kanamycin whiB7 c.-68C>G whiB7_c.-68C>G 1 upstream_gene_variant 3568747 1 1 1 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.150201697158088 Inf 0.14581791265729 60 1879 False False Inf 0.150201697158088 Inf 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-71_-70insC whiB7_c.-71_-70insC 1 upstream_gene_variant 3568749 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-71C>G whiB7_c.-71C>G 1 upstream_gene_variant 3568750 1 3 0 3 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 14.1782880202046 1 617 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-78A>G whiB7_c.-78A>G 1 upstream_gene_variant 3568757 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-7A>G whiB7_c.-7A>G 1 upstream_gene_variant 3568686 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1512 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 816 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-80A>C whiB7_c.-80A>C 1 upstream_gene_variant 3568759 1 23 9 14 9 15 3537 20757 0.00253807106598984 0.001161204060764 0.00481255792904073 0.999277874061236 0.998809242329947 0.999595777053137 0.375 0.187992928196002 0.594063615992055 0.391304347826087 0.197076423969014 0.61458104261115 0.375 0.187992928196002 0.594063615992055 3.77262813522355 1.43914409822907 9.36386827650377 0.00346164749520595 25 1879 False False 3.52111959287531 1.35743532682811 8.59530251764987 0.00253807106598984 0.001161204060764 0.00481255792904073 0.999277874061236 0.998809242329947 0.999595777053137 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 13 5 8 5 8 1602 6345 0.00311138767890479 0.00101100708660053 0.00724588638281331 0.99874075240044 0.997520296036287 0.99945619445686 0.384615384615384 0.13857933889016 0.684222397085936 0.384615384615384 0.13857933889016 0.684222397085936 0.384615384615384 0.13857933889016 0.684222397085936 2.4754213483146 0.636182589008145 8.59374070112856 0.15542540984588 28 992 False False 0 0 0 0 0 0 0 2.4754213483146 0.636182589008145 8.59374070112856 0.00311138767890479 0.00101100708660053 0.00724588638281331 0.99874075240044 0.997520296036287 0.99945619445686 47 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-89A>G whiB7_c.-89A>G 1 upstream_gene_variant 3568768 1 11 0 11 0 11 3546 20761 0 0 0.0010397522169524 0.99947044097824 0.999052670645628 0.99973561734751 0 0 0.284914152918154 0 0 0.284914152918154 0 0 0.284914152918154 0 0 2.33394419599086 0.385127888074456 118 1879 False False 0 0 2.33394419599086 0 0 0.0010397522169524 0.99947044097824 0.999052670645628 0.99973561734751 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 c.-8A>T whiB7_c.-8A>T 1 upstream_gene_variant 3568687 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1507 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 810 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 7 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB7 LoF whiB7_LoF 1 LoF (see "Genomic_coordinates" sheet) 1 81 1 80 22 151 3524 20621 0.00620417371686407 0.00389208604824604 0.0093782100505535 0.992730598883112 0.991479615121111 0.993840531195249 0.127167630057803 0.0814403948252627 0.186182823567561 0.0123456790123456 0.000312516687153829 0.0668756209322107 0.00657894736842105 0.000166550655111892 0.0361090337374659 0.0731448637911464 0.00183275405396586 0.419670596570119 9.25295852098968e-05 17 1879 True False 0.8525494057776 0.518059957113444 1.34098715860727 0.00028368794326241 7.18233108191246e-06 0.00157958347388303 0.992730598883112 0.991479615121111 0.993840531195249 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 27 0 27 4 46 1603 6307 0.00248911014312383 0.000678602218007884 0.00636074311848652 0.992759326302534 0.990353640361029 0.994694181363682 0.08 0.0222279636549297 0.192342783595962 0 0 0.127702867615432 0 0 0.0770618270519006 0 0 0.576853192903805 0.00326314844926118 15 992 False False 0 0 0 0 0 0 0 0.342130244921207 0.0893499443053527 0.939136712561068 0 0 0.00229858903252049 0.992759326302534 0.990353640361029 0.994694181363682 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB7 p.Ala34Pro whiB7_p.Ala34Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1511 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 815 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB7 p.Ala55Glu whiB7_p.Ala55Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 p.Ala90Ser whiB7_p.Ala90Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 p.Ala92Thr whiB7_p.Ala92Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1517 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 820 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB7 p.Arg12fs whiB7_p.Arg12fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 3545 20771 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999951858270749 0.999731800967312 0.999998781157685 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 5.8592383638928 0.0746220616644107 458.169367733398 0.270378083801644 96 1879 False False 5.8592383638928 0.0746220616644107 458.169367733398 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB7 p.Arg12Lys whiB7_p.Arg12Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 14.1782880202046 1 617 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 p.Arg50Leu whiB7_p.Arg50Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 3546 20769 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1500 1879 False False 0 0 14.1782880202046 0 0 0.0010397522169524 0.999855574812247 0.999577986903419 0.999970215063798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Kanamycin whiB7 p.Arg50Pro whiB7_p.Arg50Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1505 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1607 6351 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 809 992 False False 0 0 0 0 0 0 0 0 0 21.0580478247511 0 0 0.0022928741555424 0.99968518810011 0.99886325869706 0.999961872544366 NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 p.Arg59Trp whiB7_p.Arg59Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 p.Arg81Cys whiB7_p.Arg81Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 p.Arg81fs whiB7_p.Arg81fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 14 52 3532 20720 0.00394811054709531 0.00216009836545967 0.00661539465241288 0.997496630078952 0.996718443272328 0.998129815721086 0.212121212121212 0.121101932255142 0.33021145964782 0 0 0.975 0 0 0.0684822087033195 0 0 227.987772517665 1 617 1879 False False 1.5794058715916 0.807402822583842 2.89585763505122 0 0 0.00104387139328999 0.997496630078952 0.996718443272328 0.998129815721086 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 12 1605 6341 0.00124455507156191 0.000150756945780856 0.00448845844972244 0.998111128600661 0.99670284884972 0.999023623643625 0.142857142857142 0.0177945154831915 0.428129160909698 NA NA NA 0 0 0.264648469397051 NA NA NA NA 812 992 False False 0 0 0 0 0 0 0 0.658463136033229 0.0715087694828444 2.96233507582142 0 0 0.0022957280374523 0.998111128600661 0.99670284884972 0.999023623643625 2 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB7 p.Arg81His whiB7_p.Arg81His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1509 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 811 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 NA Not assoc w R 3) Uncertain significance DOWN from NotAwR to Uncertain yes 2 +Kanamycin whiB7 p.Arg87Cys whiB7_p.Arg87Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 p.Asp24His whiB7_p.Asp24His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 227.636869136849 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 822 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 16 3) Uncertain significance No change no 1 +Kanamycin whiB7 p.Asp31Asn whiB7_p.Asp31Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB7 p.Gln13Lys whiB7_p.Gln13Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 0 0 0.975 0 0 0.975 0 0 153.811699906182 1 233 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB7 p.Gln58Arg whiB7_p.Gln58Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 7 3546 20765 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 4.97562348401969 0.602098244373112 132 1879 False False 0 0 4.06480602430196 0 0 0.0010397522169524 0.999663007895243 0.999305791518941 0.999864501305137 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance No change no 1 +Kanamycin whiB7 p.Gln73Arg whiB7_p.Gln73Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 3546 20770 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 31.2177754884198 1 617 1879 False False 0 0 31.2177754884198 0 0 0.0010397522169524 0.999903716541498 0.99965223478104 0.999988339413789 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 p.Glu69Gly whiB7_p.Glu69Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB7 p.Glu69Lys whiB7_p.Glu69Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Kanamycin whiB7 p.Gly23Asp whiB7_p.Gly23Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Kanamycin whiB7 p.Gly64fs whiB7_p.Gly64fs 1 frameshift (see "Genomic_coordinates" sheet) 1 77 0 77 0 87 3546 20685 0 0 0.0010397522169524 0.99581166955517 0.994836237820393 0.996643999677307 0 0 0.0415145659926378 0 0 0.046778068160404 0 0 0.0415145659926378 0 0 0.286450643309315 1.1279734975812e-05 14 1879 True False 0 0 0.252818430978434 0 0 0.0010397522169524 0.99581166955517 0.994836237820393 0.996643999677307 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 27 0 27 0 33 1607 6320 0 0 0.0022928741555424 0.994805603651818 0.992712801685182 0.996421799060194 0 0 0.105762810074579 0 0 0.127702867615432 0 0 0.105762810074579 0 0 0.576601267469802 0.00326143359410525 14 992 False False 0 0 0 0 0 0 0 0 0 0.46582869807024 0 0 0.0022928741555424 0.994805603651818 0.992712801685182 0.996421799060194 830 3) Uncertain significance No change no 1 +Kanamycin whiB7 p.Gly67Val whiB7_p.Gly67Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 11 0 11 0 11 3546 20761 0 0 0.0010397522169524 0.99947044097824 0.999052670645628 0.99973561734751 0 0 0.284914152918154 0 0 0.284914152918154 0 0 0.284914152918154 0 0 2.33394419599086 0.385127888074456 118 1879 False False 0 0 2.33394419599086 0 0 0.0010397522169524 0.99947044097824 0.999052670645628 0.99973561734751 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 0 10 1607 6343 0 0 0.0022928741555424 0.99842594050055 0.997107159926049 0.999244927346731 0 0 0.30849710781876 0 0 0.30849710781876 0 0 0.30849710781876 0 0 1.76303467972913 0.228805637438717 44 992 False False 0 0 0 0 0 0 0 0 0 1.76303467972913 0 0 0.0022928741555424 0.99842594050055 0.997107159926049 0.999244927346731 2 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB7 p.Gly74Asp whiB7_p.Gly74Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1513 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 817 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB7 p.Gly84_Arg87del whiB7_p.Gly84_Arg87del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 26 0 26 4 36 3542 20736 0.00112803158488437 0.000307433460438748 0.00288566784728404 0.998266897746967 0.997601455379579 0.998785870383798 0.1 0.0279254152942193 0.236637399876099 0 0 0.132274604497754 0 0 0.0973937559144919 0 0 0.892927826266661 0.0253670091287282 35 1879 False False 0.65047995482778 0.168108010647332 1.81645018097032 0 0 0.00104092580348739 0.998266897746967 0.997601455379579 0.998785870383798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 21 0 21 2 24 1605 6329 0.00124455507156191 0.000150756945780856 0.00448845844972244 0.996222257201322 0.994384200008006 0.997578074772697 0.0769230769230769 0.00945539100371274 0.251302916695373 0 0 0.161097615219079 0 0 0.142473597722525 0 0 0.758347156158693 0.0130496857603707 16 992 False False 0 0 0 0 0 0 0 0.328608515057113 0.0376077431631709 1.32604344568457 0 0 0.0022957280374523 0.996222257201322 0.994384200008006 0.997578074772697 22 3) Uncertain significance No change no 1 +Kanamycin whiB7 p.His21Gln whiB7_p.His21Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.150201697158088 Inf 0.14581791265729 60 1879 False False Inf 0.150201697158088 Inf 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 p.His79Gln whiB7_p.His79Gln 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 15 58 3531 20714 0.00423011844331641 0.0023694392623031 0.00696735420989913 0.997207779703447 0.996391883550761 0.997879088111795 0.205479452054794 0.119813098335436 0.316161599197041 NA NA NA 0 0 0.0616210089039198 NA NA NA NA 1523 1879 False False 1.51715348782702 0.797603236942823 2.71582079573455 0 0 0.00104416686942014 0.997207779703447 0.996391883550761 0.997879088111795 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 12 1605 6341 0.00124455507156191 0.000150756945780856 0.00448845844972244 0.998111128600661 0.99670284884972 0.999023623643625 0.142857142857142 0.0177945154831915 0.428129160909698 NA NA NA 0 0 0.264648469397051 NA NA NA NA 823 992 False False 0 0 0 0 0 0 0 0.658463136033229 0.0715087694828444 2.96233507582142 0 0 0.0022957280374523 0.998111128600661 0.99670284884972 0.999023623643625 1 Not assoc w R 3) Uncertain significance DOWN from NotAwR to Uncertain yes 2 +Kanamycin whiB7 p.Ile76Val whiB7_p.Ile76Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 p.Leu18Phe whiB7_p.Leu18Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB7 p.Leu27Pro whiB7_p.Leu27Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1526 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 826 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB7 p.Leu36Phe whiB7_p.Leu36Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 p.Leu42Pro whiB7_p.Leu42Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 10 48 3536 20724 0.00282007896221094 0.00135314014136576 0.00518009078773565 0.997689196995956 0.996937364311925 0.998295719816628 0.172413793103448 0.085903995331614 0.29429900573891 NA NA NA 0 0 0.0739727853472802 NA NA NA NA 1502 1879 False False 1.22101244343891 0.550282219014178 2.44698037393176 0 0 0.00104269115914271 0.997689196995956 0.996937364311925 0.998295719816628 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 5 1606 6348 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 0.999212970250275 0.99816429885228 0.999744405769873 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA 0 0 0.521823750104981 NA NA NA NA 807 992 False False 0 0 0 0 0 0 0 0.790535491905354 0.0167037613038365 7.07198409929284 0 0 0.00229430020901157 0.999212970250275 0.99816429885228 0.999744405769873 3 Not assoc w R 3) Uncertain significance DOWN from NotAwR to Uncertain yes 2 +Kanamycin whiB7 p.Lys40Asn whiB7_p.Lys40Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Kanamycin whiB7 p.Lys80Gln whiB7_p.Lys80Gln 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 15 58 3531 20714 0.00423011844331641 0.0023694392623031 0.00696735420989913 0.997207779703447 0.996391883550761 0.997879088111795 0.205479452054794 0.119813098335436 0.316161599197041 NA NA NA 0 0 0.0616210089039198 NA NA NA NA 1493 1879 False False 1.51715348782702 0.797603236942823 2.71582079573455 0 0 0.00104416686942014 0.997207779703447 0.996391883550761 0.997879088111795 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 12 1605 6341 0.00124455507156191 0.000150756945780856 0.00448845844972244 0.998111128600661 0.99670284884972 0.999023623643625 0.142857142857142 0.0177945154831915 0.428129160909698 NA NA NA 0 0 0.264648469397051 NA NA NA NA 803 992 False False 0 0 0 0 0 0 0 0.658463136033229 0.0715087694828444 2.96233507582142 0 0 0.0022957280374523 0.998111128600661 0.99670284884972 0.999023623643625 1 Not assoc w R 3) Uncertain significance DOWN from NotAwR to Uncertain yes 2 +Kanamycin whiB7 p.Phe29Ile whiB7_p.Phe29Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1498 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 p.Pro11Ser whiB7_p.Pro11Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 8 3546 20764 0 0 0.0010397522169524 0.999614866165992 0.999241274614236 0.99983371235125 0 0 0.369416647552819 0 0 0.409616397225003 0 0 0.369416647552819 0 0 4.06461026139319 0.603473084876286 149 1879 False False 0 0 3.43205141622579 0 0 0.0010397522169524 0.999614866165992 0.999241274614236 0.99983371235125 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 3) Uncertain significance No change no 1 +Kanamycin whiB7 p.Pro25Leu whiB7_p.Pro25Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1515 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1607 6352 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 818 992 False False 0 0 0 0 0 0 0 0 0 153.811699906182 0 0 0.0022928741555424 0.999842594050055 0.999123305664052 0.999996014834324 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB7 p.Pro33Ser whiB7_p.Pro33Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1492 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB7 p.Pro62Thr whiB7_p.Pro62Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1514 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Kanamycin whiB7 p.Ser2Ala whiB7_p.Ser2Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Kanamycin whiB7 p.Ser45Arg whiB7_p.Ser45Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1524 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 824 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB7 p.Thr10_Gln13del whiB7_p.Thr10_Gln13del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Kanamycin whiB7 p.Thr10Ser whiB7_p.Thr10Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 p.Thr32Asn whiB7_p.Thr32Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1504 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Kanamycin whiB7 p.Trp63* whiB7_p.Trp63* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 p.Val22Ile whiB7_p.Val22Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Kanamycin whiB7 p.Val3Ala whiB7_p.Val3Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 3545 20771 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 0.999951858270749 0.999731800967312 0.999998781157685 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1508 1879 False False 5.8592383638928 0.0746220616644107 458.169367733398 0 0 0.00104004536542481 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Kanamycin whiB7 p.Val65fs whiB7_p.Val65fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 7 10 3539 20762 0.00197405527354765 0.000794029400507555 0.00406305244102797 0.99951858270749 0.999114835261082 0.999769118326375 0.411764705882352 0.184436961783946 0.670752846053242 NA NA NA 0 0 0.30849710781876 NA NA NA NA 1520 1879 False False 4.10664029386832 1.32567441369327 11.9595047200366 0 0 0.00104180773346159 0.99951858270749 0.999114835261082 0.999769118326375 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 1 1605 6352 0.00124455507156191 0.000150756945780856 0.00448845844972244 0.999842594050055 0.999123305664052 0.999996014834324 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 821 992 False False 0 0 0 0 0 0 0 7.91526479750778 0.41169480990745 465.597805007535 0 0 0.0022957280374523 0.999842594050055 0.999123305664052 0.999996014834324 2 3) Uncertain significance No change no 1 +Kanamycin whiB7 p.Val65Phe whiB7_p.Val65Phe 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1510 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 814 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 NA 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB7 p.Val91Gly whiB7_p.Val91Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 3545 20772 0.000282007896221094 7.13979627811244e-06 0.00157023494819483 1 0.99982242673208 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1503 1879 False False Inf 0.150201697158088 Inf 0 0 0.00104004536542481 1 0.99982242673208 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1606 6353 0.000622277535780958 1.57545790591552e-05 0.0034621808695534 1 0.999419516970794 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 808 992 False False 0 0 0 0 0 0 0 Inf 0.101367337197729 Inf 0 0 0.00229430020901157 1 0.999419516970794 1 1 3) Uncertain significance New Uncertain no 0 +Kanamycin whiB7 p.Val91Ile whiB7_p.Val91Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 3546 20771 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 0 0 0.975 0 0 0.975 0 0 0.975 0 0 227.647789514565 1 617 1879 False False 0 0 227.647789514565 0 0 0.0010397522169524 0.999951858270749 0.999731800967312 0.999998781157685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK c.1011G>A glpK_c.1011G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.1035G>A glpK_c.1035G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.1050C>T glpK_c.1050C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 5843 21458 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.0087500478358 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 5 2720 9634 0 0 0.00135528645033659 0.999481273991078 0.998789885214303 0.999831550309162 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.8675231049739 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.1071C>A glpK_c.1071C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.1089G>A glpK_c.1089G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.1102C>T glpK_c.1102C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 39 5843 21424 0 0 0.000631133876986172 0.998182919442762 0.997516819563471 0.998707568843746 0 0 0.0902511009603342 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.363887429259831 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 15 2720 9624 0 0 0.00135528645033659 0.998443821973233 0.997434617850146 0.99912876560277 0 0 0.218019360910534 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.987286325703696 NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.1134C>T glpK_c.1134C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 503 1876 5340 19587 0.08608591476981 0.0790163440738581 0.0935718759175351 0.912593766015934 0.908735911247905 0.916339443494722 0.211433375367801 0.195178306713358 0.228402006189016 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.983471586689346 0.885461570534067 1.09091063382136 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 192 491 2528 9148 0.0705882352941176 0.0612448411027477 0.0808678950566229 0.949061105923851 0.944482260064691 0.953366111835008 0.281112737920937 0.24767396630091 0.316455391736359 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 0 1.41504034648998 1.18433518066704 1.68543928960639 NA NA NA NA NA NA 3417 5) Not assoc w R Now listed Silent mutation no 0 +Levofloxacin glpK c.1137C>T glpK_c.1137C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.1161C>T glpK_c.1161C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.1164C>T glpK_c.1164C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.117G>C glpK_c.117G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 5 5841 21458 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.9997670409542 0.99945643574724 0.999924354643808 0.285714285714285 0.0366925661760855 0.709579136262657 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.46947440506762 0.139870903520674 8.97864690973746 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.1209C>T glpK_c.1209C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.120C>T glpK_c.120C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.67374186922286 0.0467931454016956 287.712465214691 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.123C>A glpK_c.123C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 7 20 5836 21443 0.00119801471846654 0.000481795418920789 0.00246680058103687 0.999068163816801 0.998561219655491 0.999430720271997 0.259259259259259 0.111144562845442 0.462848742276171 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.28599211788896 0.459213271828262 3.16797420996159 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 2 2718 9637 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 0.999792509596431 0.999250676427901 0.999974870961701 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.54562178072111 0.256860512408561 48.9209196354209 NA NA NA NA NA NA 15 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.1245C>T glpK_c.1245C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.1257C>G glpK_c.1257C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.1260G>A glpK_c.1260G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.1269G>A glpK_c.1269G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 5843 21458 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.0087500478358 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 23 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.1278T>C glpK_c.1278T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.129G>A glpK_c.129G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.1302G>A glpK_c.1302G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.1305T>C glpK_c.1305T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.1317G>A glpK_c.1317G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 5840 21463 0.000513434879342803 0.000105895133877182 0.00149973424244328 1 0.999828143201531 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.51820267072123 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.1329G>A glpK_c.1329G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 1 5841 21462 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99995340819084 0.99974043469953 0.999998820398217 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 7.3487416538264 0.382468755528661 432.333734199629 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.1341G>T glpK_c.1341G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 14 5843 21449 0 0 0.000631133876986172 0.99934771467176 0.998905818000026 0.999643345117175 0 0 0.231635761650116 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.10705976842086 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 7 2720 9632 0 0 0.00135528645033659 0.999273783587509 0.99850429270085 0.999707975074577 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.45859411933764 NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.141G>A glpK_c.141G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.1422G>A glpK_c.1422G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.1428T>C glpK_c.1428T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.1437C>G glpK_c.1437C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.1446A>C glpK_c.1446A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 12 5842 21451 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99944089829008 0.999023565718772 0.999711071680148 0.0769230769230769 0.00194562849734675 0.360297435267877 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.305988246034463 0.00716032492979931 2.06893448789797 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 11 2719 9628 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.998858802780371 0.997959002506684 0.999430185159088 0.0833333333333333 0.00210759323186022 0.384796165150944 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.321909793038884 0.00747960585022801 2.21688560239189 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.1497T>G glpK_c.1497T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.1503C>T glpK_c.1503C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.1518G>A glpK_c.1518G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.1527G>A glpK_c.1527G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 1 5840 21462 0.000513434879342803 0.000105895133877182 0.00149973424244328 0.99995340819084 0.99974043469953 0.999998820398217 0.75 0.194120449683243 0.99369053679029 NA NA NA NA NA NA NA NA NA NA NA NA False False 11.025 0.884946155157416 576.804300084131 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.1530C>T glpK_c.1530C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.153C>T glpK_c.153C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.1542T>C glpK_c.1542T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.89146792489366 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.1551C>G glpK_c.1551C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.1551C>T glpK_c.1551C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 12 5843 21451 0 0 0.000631133876986172 0.99944089829008 0.999023565718772 0.999711071680148 0 0 0.264648469397051 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.32173650369041 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 11 2720 9628 0 0 0.00135528645033659 0.998858802780371 0.997959002506684 0.999430185159088 0 0 0.284914152918154 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.41143234851738 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.159C>T glpK_c.159C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 11 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.-18C>T glpK_c.-18C>T 2 upstream_gene_variant 4139773 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK c.-19T>G glpK_c.-19T>G 2 upstream_gene_variant 4139774 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK c.201C>A glpK_c.201C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.234C>G glpK_c.234C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.234C>T glpK_c.234C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.238C>T glpK_c.238C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.246G>A glpK_c.246G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 7 5843 21456 0 0 0.000631133876986172 0.99967385733588 0.999328137654343 0.999868864001311 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.5485399472607 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.57852451631077 NA NA NA NA NA NA 17 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.264G>A glpK_c.264G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.267G>T glpK_c.267G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.27A>G glpK_c.27A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 5 5841 21458 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.9997670409542 0.99945643574724 0.999924354643808 0.285714285714285 0.0366925661760855 0.709579136262657 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.46947440506762 0.139870903520674 8.97864690973746 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 18.8709233025667 NA NA NA NA NA NA 17 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.288G>A glpK_c.288G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 18.8709233025667 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.309C>T glpK_c.309C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.89146792489366 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.318G>A glpK_c.318G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 5841 21463 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 1 0.999828143201531 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.689929368506768 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 2718 9639 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 1 0.999617369678334 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.665658435310444 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.330C>T glpK_c.330C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.336T>C glpK_c.336T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.33C>T glpK_c.33C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.-34C>T glpK_c.-34C>T 2 upstream_gene_variant 4139789 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1850 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1016 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK c.354C>T glpK_c.354C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.369G>T glpK_c.369G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.-38C>T glpK_c.-38C>T 2 upstream_gene_variant 4139793 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK c.39C>G glpK_c.39C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.414G>A glpK_c.414G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.417G>A glpK_c.417G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 22 5843 21441 0 0 0.000631133876986172 0.998974980198481 0.998448516553724 0.999357517570523 0 0 0.154372512815574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.670152019329168 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.420C>T glpK_c.420C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.435T>A glpK_c.435T>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.444T>G glpK_c.444T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 5842 21461 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99990681638168 0.999663429698698 0.999988714832292 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.83678534748373 0.0311281139040964 35.2896458967866 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.-47_-45delGCG glpK_c.-47_-45delGCG 2 upstream_gene_variant 4139799 1 4 0 4 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.56487735727821 0.58431003819195 215.5 2040 False False 0 0 5.56487735727821 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK c.492G>T glpK_c.492G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.495C>G glpK_c.495C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 5842 21461 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99990681638168 0.999663429698698 0.999988714832292 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.83678534748373 0.0311281139040964 35.2896458967866 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 2719 9637 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999792509596431 0.999250676427901 0.999974870961701 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.77215888194189 0.0300270423699391 34.0580978516331 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.510C>T glpK_c.510C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 76 169 5767 21294 0.013007016943351 0.0102613662571599 0.0162535220972596 0.992125984251968 0.990851121991046 0.993264698288109 0.310204081632653 0.252855022925946 0.372214885480214 NA NA NA NA NA NA NA NA NA NA NA NA False True 1.66048205306051 1.24755019315082 2.19286168835391 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 34 74 2686 9565 0.0125 0.00867172415263987 0.0174240546902857 0.992322855067953 0.990371508019517 0.993967120973105 0.314814814814814 0.228835220128551 0.411249811224377 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 0 1.63616147793362 1.05421280618413 2.49367552539117 NA NA NA NA NA NA 301 5) Not assoc w R Now listed Silent mutation no 0 +Levofloxacin glpK c.525A>G glpK_c.525A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 5843 21458 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.0087500478358 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.531C>T glpK_c.531C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.570G>A glpK_c.570G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.582C>A glpK_c.582C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.-5A>G glpK_c.-5A>G 2 upstream_gene_variant 4139760 1 20 0 20 2 20 5841 21443 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.999068163816801 0.998561219655491 0.999430720271997 0.0909090909090909 0.0112055860241509 0.291612741553933 0 0 0.168433470983085 0 0 0.168433470983085 0 0 0.743853714387399 0.0124539946729131 38 2040 False False 0.367111795925355 0.0415943473659495 1.5120327780201 0 0 0.000631349913487419 0.999068163816801 0.998561219655491 0.999430720271997 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 1 7 2719 9632 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999273783587509 0.99850429270085 0.999707975074577 0.125 0.0031597235312519 0.526509670875206 0 0 0.409616397225003 0 0 0.409616397225003 0 0 2.45949873668362 0.359610162200782 97 1102 False False 0 0 0 0 0 0 0 0.506068407502758 0.0112282467919303 3.94205250693349 0 0 0.0013557845626193 0.999273783587509 0.99850429270085 0.999707975074577 7 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK c.60C>T glpK_c.60C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.624A>C glpK_c.624A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 10 5841 21453 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.9995340819084 0.999143327515781 0.999776552276323 0.166666666666666 0.0208625254600923 0.484137748685967 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.734565998972778 0.0782362563354321 3.44840829907378 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 18.8709233025667 NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.63C>T glpK_c.63C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.645C>T glpK_c.645C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.649C>T glpK_c.649C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 5843 21457 0 0 0.000631133876986172 0.99972044914504 0.999391635540124 0.999897403075094 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.1200699364824 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 6 2720 9633 0 0 0.00135528645033659 0.999377528789293 0.998645638320949 0.999771530871485 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.00974784500922 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.708G>A glpK_c.708G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.708G>T glpK_c.708G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.717T>C glpK_c.717T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.726C>T glpK_c.726C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.741G>T glpK_c.741G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 17 5841 21446 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99920793924428 0.99873213590018 0.999538529867378 0.105263157894736 0.0130121643717774 0.331376664456765 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.431956655286665 0.0483961600105398 1.82051804673259 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 15 2718 9624 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 0.998443821973233 0.997434617850146 0.99912876560277 0.117647058823529 0.0145793168403025 0.36440916210125 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.472111846946284 0.052361071946615 2.03224769623507 NA NA NA NA NA NA 23 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.759G>A glpK_c.759G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.759G>T glpK_c.759G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.75C>A glpK_c.75C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.75C>T glpK_c.75C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.765C>T glpK_c.765C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.777C>A glpK_c.777C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.789T>C glpK_c.789T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.795C>T glpK_c.795C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.-7A>G glpK_c.-7A>G 2 upstream_gene_variant 4139762 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK c.810C>T glpK_c.810C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.816G>A glpK_c.816G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.84C>T glpK_c.84C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.852C>T glpK_c.852C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.859C>T glpK_c.859C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.873C>T glpK_c.873C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.891A>G glpK_c.891A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 4 5841 21459 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99981363276336 0.999522895233871 0.999949218940757 0.333333333333333 0.0432718682927417 0.777221904496487 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.83692860811504 0.166109303397098 12.8208569329986 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 1 2718 9638 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 0.999896254798215 0.999422105789591 0.999997373402351 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 7.09197939661515 0.368993183584618 417.296682266591 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.-8T>C glpK_c.-8T>C 2 upstream_gene_variant 4139763 NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1821 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK c.900C>T glpK_c.900C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.56487735727821 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.906G>A glpK_c.906G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.912C>T glpK_c.912C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.67374186922286 0.0467931454016956 287.712465214691 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.945C>T glpK_c.945C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.969C>T glpK_c.969C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.96C>T glpK_c.96C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 4 5842 21459 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99981363276336 0.999522895233871 0.999949218940757 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.918307086614173 0.0186435710006194 9.27999188457764 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.978C>T glpK_c.978C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin glpK c.-9T>G glpK_c.-9T>G 2 upstream_gene_variant 4139764 NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1788 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 977 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK deletion glpK_deletion 2 feature_ablation (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 142.93371627475 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK LoF glpK_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 167 6 161 97 224 5746 21239 0.0166010610987506 0.0134824233222816 0.0202148140644702 0.989563434748171 0.9881121893224 0.990879680479987 0.302180685358255 0.252420278235842 0.35563570286682 0.0359281437125748 0.0132971254332162 0.0765573035016032 0.0260869565217391 0.00963232368508743 0.0559126653412148 0.13775070100075 0.0497969204003003 0.30666589038763 1.07164744627488e-10 11 2040 True False 1.600634447566 1.24572706246001 2.04393394286963 0.00104311543810848 0.000382898130908239 0.00226903014801036 0.989563434748171 0.9881121893224 0.990879680479987 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 71 2 69 64 93 2656 9546 0.0235294117647058 0.0181665476133037 0.0299482789209888 0.990351696234049 0.988193030333727 0.992205710788201 0.40764331210191 0.330007296849177 0.488833823593022 0.028169014084507 0.00342979077123614 0.0980800686570548 0.0210526315789473 0.00255981798606167 0.0739865474288274 0.104177579884756 0.0123629067314068 0.391352711475855 8.78401693098513e-06 11 1102 True False 0 0 0 0 0 0 0 2.4733773804897 1.76478222154377 3.44754790161408 0.000752445447705041 9.11376277778682e-05 0.00271542158146775 0.990351696234049 0.988193030333727 0.992205710788201 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Ala111Glu glpK_p.Ala111Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0941866911272879 Inf 0.213982274957884 105.5 2040 False False Inf 0.0941866911272879 Inf 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Ala11Val glpK_p.Ala11Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 5 5843 21458 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 8.89063948722811 1 883 2040 False False 0 0 4.0087500478358 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Ala164Thr glpK_p.Ala164Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1842 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0 0 0.00063124187675269 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Ala19Asp glpK_p.Ala19Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Ala245Thr glpK_p.Ala245Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Ala265fs glpK_p.Ala265fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Ala277Gly glpK_p.Ala277Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Ala313Thr glpK_p.Ala313Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 5 5843 21458 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1783 2040 False False 0 0 4.0087500478358 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Ala318Thr glpK_p.Ala318Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1827 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1001 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Ala324Thr glpK_p.Ala324Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1854 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Ala364Val glpK_p.Ala364Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 1 5 5842 21458 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.9997670409542 0.99945643574724 0.999924354643808 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.602364635616474 0 0 0.521823750104981 0 0 5.56557073483698 0.584317496465312 233.5 2040 False False 0.73461143444026 0.0155328045999449 6.56618384712436 0 0 0.00063124187675269 0.9997670409542 0.99945643574724 0.999924354643808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1004 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 4 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Ala370fs glpK_p.Ala370fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Ala377Val glpK_p.Ala377Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Ala37Val glpK_p.Ala37Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1803 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 989 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Ala396fs glpK_p.Ala396fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Ala396Ser glpK_p.Ala396Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1784 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 975 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Ala400Val glpK_p.Ala400Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Ala40Ser glpK_p.Ala40Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5841 21463 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 1 0.999828143201531 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1834 2040 False False Inf 0.689929368506768 Inf 0 0 0.000631349913487419 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 2718 9639 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 1 0.999617369678334 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1005 1102 False False 0 0 0 0 0 0 0 Inf 0.665658435310444 Inf 0 0 0.00135628304118183 1 0.999617369678334 1 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Ala440Gly glpK_p.Ala440Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1787 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Ala457Ser glpK_p.Ala457Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1801 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 988 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Ala463Val glpK_p.Ala463Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1828 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1002 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Ala467Val glpK_p.Ala467Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1822 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 998 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Ala472Glu glpK_p.Ala472Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Ala472Pro glpK_p.Ala472Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1804 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 990 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Ala479Thr glpK_p.Ala479Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Ala498Gly glpK_p.Ala498Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Ala498Thr glpK_p.Ala498Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Ala498Val glpK_p.Ala498Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Ala53Val glpK_p.Ala53Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Ala87Val glpK_p.Ala87Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Arg102Trp glpK_p.Arg102Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Arg121Cys glpK_p.Arg121Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 5840 21463 0.000513434879342803 0.000105895133877182 0.00149973424244328 1 0.999828143201531 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1847 2040 False False Inf 1.51820267072123 Inf 0 0 0.000631457987209345 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Arg121Ser glpK_p.Arg121Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1860 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Arg189Gln glpK_p.Arg189Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Arg225Trp glpK_p.Arg225Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0941823027901977 Inf 0.213990111701153 120.5 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0908652957857324 Inf 0.220082530949106 80 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Arg334Gly glpK_p.Arg334Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Arg395Ser glpK_p.Arg395Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0941866911272879 Inf 0.213982274957884 105.5 2040 False False Inf 0.0941866911272879 Inf 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Arg406Cys glpK_p.Arg406Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0941866911272879 Inf 0.213982274957884 105.5 2040 False False Inf 0.0941866911272879 Inf 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Arg41Cys glpK_p.Arg41Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Arg478Gln glpK_p.Arg478Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1807 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Arg509Trp glpK_p.Arg509Trp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1815 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Arg66Ser glpK_p.Arg66Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Arg94Leu glpK_p.Arg94Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Asn110fs glpK_p.Asn110fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Asn183Ser glpK_p.Asn183Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1793 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Asn199fs glpK_p.Asn199fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1844 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1011 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Asn279fs glpK_p.Asn279fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5841 21463 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 1 0.999828143201531 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1779 2040 False False Inf 0.689929368506768 Inf 0 0 0.000631349913487419 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 2718 9639 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 1 0.999617369678334 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 972 1102 False False 0 0 0 0 0 0 0 Inf 0.665658435310444 Inf 0 0 0.00135628304118183 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Asn279Lys glpK_p.Asn279Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Asn285fs glpK_p.Asn285fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Asn299Asp glpK_p.Asn299Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 13 0 13 15 16 5828 21447 0.00256717439671401 0.00143751780890291 0.00423063446053587 0.99925453105344 0.998789686679379 0.999573841954248 0.483870967741935 0.301545650712341 0.669394026948242 0 0 0.24705263800047 0 0 0.205907214207822 0 0 1.20790612053043 0.0844223309352221 72 2040 False False 3.44999356554564 1.5876912516246 7.45562478997046 0 0 0.000632757763801925 0.99925453105344 0.998789686679379 0.999573841954248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 2 6 2718 9633 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 0.999377528789293 0.998645638320949 0.999771530871485 0.25 0.0318540262499442 0.650855794412824 0 0 0.521823750104981 0 0 0.4592581264399 0 0 3.8699684394219 0.592752171548312 131 1102 False False 0 0 0 0 0 0 0 1.18138337012509 0.116521123502191 6.61177469050637 0 0 0.00135628304118183 0.999377528789293 0.998645638320949 0.999771530871485 6 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Asn356Ser glpK_p.Asn356Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1790 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 979 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Asn59Asp glpK_p.Asn59Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Asn59Ser glpK_p.Asn59Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1797 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Asn76Lys glpK_p.Asn76Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Asn79fs glpK_p.Asn79fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Asn92Ser glpK_p.Asn92Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1855 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1018 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Asp120Ala glpK_p.Asp120Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Asp120Asn glpK_p.Asp120Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Asp160Asn glpK_p.Asp160Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 3 5842 21460 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99986022457252 0.999591571764338 0.999971174018896 0.25 0.00630946320970987 0.805879550316756 0 0 0.975 0 0 0.707598226178713 0 0 142.951482085634 1 883 2040 False False 1.22446650690402 0.0233203404016305 15.2512395040111 0 0 0.00063124187675269 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 984 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Asp170Glu glpK_p.Asp170Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0941866911272879 Inf 0.213982274957884 105.5 2040 False False Inf 0.0941866911272879 Inf 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0908652957857324 Inf 0.220082530949106 80 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Asp177Gly glpK_p.Asp177Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Asp214Val glpK_p.Asp214Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Asp376Asn glpK_p.Asp376Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Asp3Asn glpK_p.Asp3Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1823 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 999 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Asp407Asn glpK_p.Asp407Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1832 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Asp446Tyr glpK_p.Asp446Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89146792489366 1 319.5 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Asp484Asn glpK_p.Asp484Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Asp492Gly glpK_p.Asp492Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Asp493fs glpK_p.Asp493fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Asp84Glu glpK_p.Asp84Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 33 0 33 1 33 5842 21430 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.998462470297721 0.997841408000016 0.998941406264571 0.0294117647058823 0.00074436423469026 0.153267669560317 0 0 0.105762810074579 0 0 0.105762810074579 0 0 0.434054005643124 0.000484921245656476 26 2040 True False 0.111159524031828 0.00273597406073755 0.664324151985893 0 0 0.00063124187675269 0.998462470297721 0.997841408000016 0.998941406264571 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 0 10 2720 9629 0 0 0.00135528645033659 0.998962547982155 0.998092919138308 0.999502392880449 0 0 0.30849710781876 0 0 0.30849710781876 0 0 0.30849710781876 0 0 1.58051507062204 0.131074447037169 50.5 1102 False False 0 0 0 0 0 0 0 0 0 1.58051507062204 0 0 0.00135528645033659 0.998962547982155 0.998092919138308 0.999502392880449 10 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Cys29Tyr glpK_p.Cys29Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 78 5839 21385 0.000684579839123737 0.000186555462570677 0.00175186028923716 0.996365838885524 0.995466447915492 0.997126318386567 0.048780487804878 0.0134490336528281 0.120211762214449 NA NA NA 0 0 0.0461924203280487 NA NA NA NA 1851 2040 False True 0.187817548667009 0.0499392156253838 0.500760700747156 0 0 0.000631566097937464 0.996365838885524 0.995466447915492 0.997126318386567 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 3 72 2717 9567 0.00110294117647058 0.000227510766880298 0.0032198465640147 0.992530345471522 0.990602328045735 0.994150998672766 0.04 0.0083261656660794 0.112476821760009 NA NA NA 0 0 0.0499440837058546 NA NA NA NA 1017 1102 False True 0 1 1 0 0 0 0 0.146715126978284 0.0295671940549736 0.446850420922648 0 0 0.00135678188642832 0.992530345471522 0.990602328045735 0.994150998672766 97 5) Not assoc w R New NotAwR yes 5 +Levofloxacin glpK p.Cys307Arg glpK_p.Cys307Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Gln262Arg glpK_p.Gln262Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1808 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Gln336His glpK_p.Gln336His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 142.964774304408 1 883 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0 0 0.00063124187675269 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Gln345Pro glpK_p.Gln345Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Gln404Glu glpK_p.Gln404Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Gln508* glpK_p.Gln508* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Gln9Glu glpK_p.Gln9Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 3 5842 21460 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99986022457252 0.999591571764338 0.999971174018896 0.25 0.00630946320970987 0.805879550316756 0 0 0.975 0 0 0.707598226178713 0 0 142.951482085634 1 883 2040 False False 1.22446650690402 0.0233203404016305 15.2512395040111 0 0 0.00063124187675269 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1014 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Glu157Gly glpK_p.Glu157Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1835 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Glu167Gly glpK_p.Glu167Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1858 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Glu209Lys glpK_p.Glu209Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 11 0 11 0 26 5843 21437 0 0 0.000631133876986172 0.998788612961841 0.998225537528248 0.999208533933273 0 0 0.132274604497754 0 0 0.284914152918154 0 0 0.132274604497754 0 0 1.46234521399194 0.135854587044562 84 2040 False False 0 0 0.559500971295389 0 0 0.000631133876986172 0.998788612961841 0.998225537528248 0.999208533933273 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 0 23 2720 9616 0 0 0.00135528645033659 0.997613860358958 0.996421757225608 0.998486809448329 0 0 0.148185128915224 0 0 0.369416647552819 0 0 0.148185128915224 0 0 2.07259102001202 0.213239618511834 58 1102 False False 0 0 0 0 0 0 0 0 0 0.615521952488556 0 0 0.00135528645033659 0.997613860358958 0.996421757225608 0.998486809448329 52 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Glu216Gln glpK_p.Glu216Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1816 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Glu230Ala glpK_p.Glu230Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 5 5842 21458 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.9997670409542 0.99945643574724 0.999924354643808 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.841886116991581 0 0 0.521823750104981 0 0 19.5681925261453 1 883 2040 False False 0.73461143444026 0.0155328045999449 6.56618384712436 0 0 0.00063124187675269 0.9997670409542 0.99945643574724 0.999924354643808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 137.961202437293 1 457.5 1102 False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 0 0 0.0013557845626193 0.999896254798215 0.999422105789591 0.999997373402351 9 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Glu276Gly glpK_p.Glu276Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 4 5842 21459 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99981363276336 0.999522895233871 0.999949218940757 0.2 0.00505076337946806 0.716417936118089 0 0 0.707598226178713 0 0 0.602364635616474 0 0 8.89257553126729 1 883 2040 False False 0.918307086614173 0.0186435710006194 9.27999188457764 0 0 0.00063124187675269 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 137.961202437293 1 457.5 1102 False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 0 0 0.0013557845626193 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Glu320Lys glpK_p.Glu320Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Glu38Gly glpK_p.Glu38Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5841 21463 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 1 0.999828143201531 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1856 2040 False False Inf 0.689929368506768 Inf 0 0 0.000631349913487419 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Glu413Lys glpK_p.Glu413Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Glu495Gly glpK_p.Glu495Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Glu65Gly glpK_p.Glu65Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Gly140Asp glpK_p.Gly140Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1794 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Gly150Asp glpK_p.Gly150Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1848 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Gly161Arg glpK_p.Gly161Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Gly169Arg glpK_p.Gly169Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1836 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1006 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Gly187Glu glpK_p.Gly187Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0941866911272879 Inf 0.213982274957884 105.5 2040 False False Inf 0.0941866911272879 Inf 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Gly191dup glpK_p.Gly191dup 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 6 0 6 2 12 5841 21451 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99944089829008 0.999023565718772 0.999711071680148 0.142857142857142 0.0177945154831915 0.428129160909698 0 0 0.4592581264399 0 0 0.264648469397051 0 0 3.12026598455711 0.352577032088666 154 2040 False False 0.612081264623637 0.0665160862429459 2.75060668897979 0 0 0.000631349913487419 0.99944089829008 0.999023565718772 0.999711071680148 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 2 2718 9637 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 0.999792509596431 0.999250676427901 0.999974870961701 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 137.997564138244 1 457.5 1102 False False 0 0 0 0 0 0 0 3.54562178072111 0.256860512408561 48.9209196354209 0 0 0.00135628304118183 0.999792509596431 0.999250676427901 0.999974870961701 68 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Gly191fs glpK_p.Gly191fs 2 frameshift (see "Genomic_coordinates" sheet) 1 15 0 15 3 17 5840 21446 0.000513434879342803 0.000105895133877182 0.00149973424244328 0.99920793924428 0.99873213590018 0.999538529867378 0.15 0.0320709371854637 0.378926826545313 0 0 0.218019360910534 0 0 0.195064322969093 0 0 1.0242466910024 0.052755715064971 60 2040 False False 0.648045930701047 0.121635161771663 2.24163362959862 0 0 0.000631457987209345 0.99920793924428 0.99873213590018 0.999538529867378 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 2 4 2718 9635 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 0.999585019192862 0.998937828281888 0.999886920491758 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.707598226178713 0 0 0.602364635616474 0 0 8.5839471073494 1 457.5 1102 False False 0 0 0 0 0 0 0 1.77244297277409 0.160228512115282 12.3744222113045 0 0 0.00135628304118183 0.999585019192862 0.998937828281888 0.999886920491758 21 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Gly247Trp glpK_p.Gly247Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Gly260Ala glpK_p.Gly260Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1843 2040 False False 0 0 5.56487735727821 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 2720 9635 0 0 0.00135528645033659 0.999585019192862 0.998937828281888 0.999886920491758 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1010 1102 False False 0 0 0 0 0 0 0 0 0 5.36894442066688 0 0 0.00135528645033659 0.999585019192862 0.998937828281888 0.999886920491758 42 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Gly301Val glpK_p.Gly301Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1838 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1008 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Gly311Glu glpK_p.Gly311Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1826 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Gly338Asp glpK_p.Gly338Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Gly342dup glpK_p.Gly342dup 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Gly379Ser glpK_p.Gly379Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1817 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Gly417Ser glpK_p.Gly417Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1786 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Gly89Ala glpK_p.Gly89Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.His103Arg glpK_p.His103Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 142.93371627475 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.His103Asn glpK_p.His103Asn 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1802 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0 0 0.00063124187675269 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.His103Tyr glpK_p.His103Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1809 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.His193fs glpK_p.His193fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 14 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.His263Tyr glpK_p.His263Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.His35Tyr glpK_p.His35Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.His392Gln glpK_p.His392Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1839 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.His42Asp glpK_p.His42Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1837 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1007 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.His42Tyr glpK_p.His42Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.His58Arg glpK_p.His58Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Ile112Val glpK_p.Ile112Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1824 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Ile223Thr glpK_p.Ile223Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1857 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Ile323Val glpK_p.Ile323Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 5840 21463 0.000513434879342803 0.000105895133877182 0.00149973424244328 1 0.999828143201531 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1818 2040 False False Inf 1.51820267072123 Inf 0 0 0.000631457987209345 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Ile401Met glpK_p.Ile401Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Ile429Thr glpK_p.Ile429Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1829 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Ile49Thr glpK_p.Ile49Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Ile5Thr glpK_p.Ile5Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Ile90fs glpK_p.Ile90fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Leu141Met glpK_p.Leu141Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Leu152Arg glpK_p.Leu152Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Leu152Val glpK_p.Leu152Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Leu218Val glpK_p.Leu218Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1798 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 985 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Leu228Val glpK_p.Leu228Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 4 163 5839 21300 0.000684579839123737 0.000186555462570677 0.00175186028923716 0.992405535106928 0.99115159746491 0.993523185898267 0.0239520958083832 0.00656383559504987 0.0601889239396139 0 0 0.841886116991581 0 0 0.0223769984930192 0 0 19.4345084521373 1 883 2040 False False 0.0895186481423304 0.0240908359429685 0.233785224074088 0 0 0.000631566097937464 0.992405535106928 0.99115159746491 0.993523185898267 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 7 2720 9632 0 0 0.00135528645033659 0.999273783587509 0.99850429270085 0.999707975074577 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 978 1102 False False 0 0 0 0 0 0 0 0 0 2.45859411933764 0 0 0.00135528645033659 0.999273783587509 0.99850429270085 0.999707975074577 354 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Leu259Phe glpK_p.Leu259Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Leu272Val glpK_p.Leu272Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Leu287Pro glpK_p.Leu287Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1813 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 996 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Leu319Arg glpK_p.Leu319Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Leu333Ile glpK_p.Leu333Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 142.964774304408 1 883 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0 0 0.00063124187675269 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 137.961202437293 1 457.5 1102 False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 0 0 0.0013557845626193 0.999896254798215 0.999422105789591 0.999997373402351 9 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Leu368Arg glpK_p.Leu368Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Leu393Val glpK_p.Leu393Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1810 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0 0 0.00063124187675269 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 993 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Leu398Pro glpK_p.Leu398Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1777 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 970 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Leu466Phe glpK_p.Leu466Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 5 3 5838 21460 0.000855724798904672 0.00027790803803495 0.00199583691247191 0.99986022457252 0.999591571764338 0.999971174018896 0.625 0.244863216366551 0.914766585862746 0 0 0.975 0 0 0.707598226178713 0 0 143.049208680327 1 883 2040 False False 6.12652734954893 1.19146359990854 39.4644754416156 0 0 0.000631674245690789 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 2 2717 9637 0.00110294117647058 0.000227510766880298 0.0032198465640147 0.999792509596431 0.999250676427901 0.999974870961701 0.6 0.146632799634673 0.947255049473683 0 0 0.975 0 0 0.841886116991581 0 0 138.048245000542 1 457.5 1102 False False 0 0 0 0 0 0 0 5.3203901361796 0.609038002991023 63.7727801541732 0 0 0.00135678188642832 0.999792509596431 0.999250676427901 0.999974870961701 7 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Lys505Asn glpK_p.Lys505Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1819 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 997 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Lys83Glu glpK_p.Lys83Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1861 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Met206Ile glpK_p.Met206Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1811 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 994 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Met266fs glpK_p.Met266fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Met359Ile glpK_p.Met359Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Met412Ile glpK_p.Met412Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.56487735727821 0.58431003819195 215.5 2040 False False 0 0 5.56487735727821 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Met412Thr glpK_p.Met412Thr 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1780 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Met412Val glpK_p.Met412Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Phe16Leu glpK_p.Phe16Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Phe16Ser glpK_p.Phe16Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Phe32Cys glpK_p.Phe32Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Phe365Leu glpK_p.Phe365Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1862 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Phe369Leu glpK_p.Phe369Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Pro176Leu glpK_p.Pro176Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Pro176Ser glpK_p.Pro176Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Pro236Ala glpK_p.Pro236Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1805 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 991 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Pro248Ser glpK_p.Pro248Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1799 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 986 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Pro254fs glpK_p.Pro254fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1845 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1012 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Pro254Ser glpK_p.Pro254Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1791 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Pro274Leu glpK_p.Pro274Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 142.93371627475 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Pro315Leu glpK_p.Pro315Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1863 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Pro354Thr glpK_p.Pro354Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Pro363Arg glpK_p.Pro363Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Pro363Ser glpK_p.Pro363Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1812 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 995 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Pro474Leu glpK_p.Pro474Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Pro489Arg glpK_p.Pro489Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Pro51Ala glpK_p.Pro51Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Ser124Leu glpK_p.Ser124Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1795 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 982 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Ser124Pro glpK_p.Ser124Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 4 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Ser124Trp glpK_p.Ser124Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1840 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Ser237Ala glpK_p.Ser237Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Ser366Cys glpK_p.Ser366Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Ser416Ala glpK_p.Ser416Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 142.964774304408 1 883 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0 0 0.00063124187675269 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 137.961202437293 1 457.5 1102 False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 0 0 0.0013557845626193 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Ser416Tyr glpK_p.Ser416Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 2 3 5841 21460 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99986022457252 0.999591571764338 0.999971174018896 0.4 0.0527449505263169 0.853367200365326 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89451223755799 1 883 2040 False False 2.44935227986075 0.204519727205419 21.3860749684357 0 0 0.000631349913487419 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Ser517Cys glpK_p.Ser517Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1789 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Ser73Trp glpK_p.Ser73Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Thr117Ile glpK_p.Thr117Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Thr185Ile glpK_p.Thr185Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1820 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Thr243Lys glpK_p.Thr243Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1778 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 971 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Thr24Ala glpK_p.Thr24Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Thr256Ile glpK_p.Thr256Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1796 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 983 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Thr280Asn glpK_p.Thr280Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Thr283fs glpK_p.Thr283fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Thr291Asn glpK_p.Thr291Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5841 21463 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 1 0.999828143201531 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1841 2040 False False Inf 0.689929368506768 Inf 0 0 0.000631349913487419 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 2718 9639 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 1 0.999617369678334 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1009 1102 False False 0 0 0 0 0 0 0 Inf 0.665658435310444 Inf 0 0 0.00135628304118183 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Thr294Met glpK_p.Thr294Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Thr304Ala glpK_p.Thr304Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Thr326Ser glpK_p.Thr326Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1830 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Thr397Ala glpK_p.Thr397Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 5842 21461 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99990681638168 0.999663429698698 0.999988714832292 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 142.958128195713 1 883 2040 False False 1.83678534748373 0.0311281139040964 35.2896458967866 0 0 0.00063124187675269 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Thr397Met glpK_p.Thr397Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Thr430Ala glpK_p.Thr430Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 17 0 17 1 22 5842 21441 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.998974980198481 0.998448516553724 0.999357517570523 0.0434782608695652 0.0011001686304415 0.21948660745348 0 0 0.195064322969093 0 0 0.154372512815574 0 0 0.88972342556733 0.0330738322911259 53 2040 False False 0.166824873175438 0.00404526541870841 1.03255326261589 0 0 0.00063124187675269 0.998974980198481 0.998448516553724 0.999357517570523 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 2720 9635 0 0 0.00135528645033659 0.999585019192862 0.998937828281888 0.999886920491758 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 8.57763452631882 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 5.36894442066688 0 0 0.00135528645033659 0.999585019192862 0.998937828281888 0.999886920491758 30 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Thr455fs glpK_p.Thr455fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0941866911272879 Inf 0.213982274957884 105.5 2040 False False Inf 0.0941866911272879 Inf 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Thr488Ile glpK_p.Thr488Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Thr490Met glpK_p.Thr490Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Thr510Ile glpK_p.Thr510Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1800 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 987 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Thr78Ala glpK_p.Thr78Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1814 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Thr97fs glpK_p.Thr97fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1849 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1015 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Trp114* glpK_p.Trp114* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Trp213* glpK_p.Trp213* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Trp471Cys glpK_p.Trp471Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1781 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 973 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Trp513Arg glpK_p.Trp513Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 2 5842 21461 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99990681638168 0.999663429698698 0.999988714832292 0.333333333333333 0.00840375865961264 0.905700675949754 0.5 0.012579117093425 0.987420882906574 0.333333333333333 0.00840375865961264 0.905700675949754 3.67357069496747 0.0467909651178817 287.699094155143 0.382194615705334 186 2040 False False 1.83678534748373 0.0311281139040964 35.2896458967866 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 976 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Tyr281* glpK_p.Tyr281* 2 stop_gained (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89146792489366 1 319.5 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Tyr308His glpK_p.Tyr308His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 142.93371627475 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 980 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Tyr372Cys glpK_p.Tyr372Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1833 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0 0 0.00063124187675269 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1003 1102 False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 0 0 0.0013557845626193 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Tyr462fs glpK_p.Tyr462fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1852 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Val113Ala glpK_p.Val113Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1831 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Val113Ile glpK_p.Val113Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Val159Ile glpK_p.Val159Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Val192fs glpK_p.Val192fs 2 frameshift (see "Genomic_coordinates" sheet) 1 130 5 125 89 183 5754 21280 0.0152319014205031 0.0122498507945481 0.0187111647421236 0.991473698923729 0.990151442171947 0.992660118824896 0.327205882352941 0.271764889130386 0.386461488125386 0.0384615384615384 0.0126043623447551 0.0874735730698071 0.026595744680851 0.00869075716914361 0.0609712386648211 0.147931873479318 0.047192303534551 0.354790053657451 3.16363204336372e-08 15 2040 True False 1.79862523765838 1.37772043462073 2.33365955136615 0.000868206285813509 0.000281962404121551 0.00202493106441588 0.991473698923729 0.990151442171947 0.992660118824896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 61 2 59 58 81 2662 9558 0.0213235294117647 0.0162306958696812 0.0274793083622801 0.991596638655462 0.989566063607041 0.993321077373816 0.417266187050359 0.334268439365142 0.503866510247689 0.0327868852459016 0.00399560316731648 0.113472167188181 0.0240963855421686 0.00293162269364637 0.0843473651878966 0.121712997746055 0.0143690335725324 0.460158816591309 0.000117247268392261 15 1102 True False 0 0 0 0 0 0 0 2.57099924868519 1.79754864752745 3.65725434139692 0.00075075075075075 9.09323336443259e-05 0.00270931176433175 0.991596638655462 0.989566063607041 0.993321077373816 437 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Val192Met glpK_p.Val192Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1859 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Val253Leu glpK_p.Val253Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 4 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Val267Ile glpK_p.Val267Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1853 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Val270Phe glpK_p.Val270Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1782 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 974 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Val330Leu glpK_p.Val330Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1806 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 992 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Val353Ala glpK_p.Val353Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Val353Phe glpK_p.Val353Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Val382Ala glpK_p.Val382Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Val39Leu glpK_p.Val39Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Val408Leu glpK_p.Val408Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1846 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1013 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Val418Asp glpK_p.Val418Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Val422Met glpK_p.Val422Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1792 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 981 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Val442Met glpK_p.Val442Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Val452Leu glpK_p.Val452Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1785 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Val460Ala glpK_p.Val460Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 121 1669 5722 19794 0.020708540133493 0.0172124012079361 0.0246939492989098 0.922238270512044 0.918574810555238 0.925786880451852 0.0675977653631284 0.0564045545251536 0.0802320723205962 NA NA NA 0 0 0.00220779257861567 NA NA NA NA 1825 2040 False True 0.25079261630711 0.20633173532018 0.302540416466421 0 0 0.000644475817824221 0.922238270512044 0.918574810555238 0.925786880451852 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 45 589 2675 9050 0.0165441176470588 0.0120923272749133 0.0220752909338182 0.938894076148978 0.933926389169337 0.943594457697841 0.0709779179810725 0.0522396134282001 0.0938238557650347 NA NA NA 0 0 0.0062433818207879 NA NA NA NA 1000 1102 False True 1 1 1 0 0 0 0 0.258477063929041 0.185946244785644 0.351538046064747 0 0 0.00137806994503524 0.938894076148978 0.933926389169337 0.943594457697841 3283 5) Not assoc w R New NotAwR yes 5 +Levofloxacin glpK p.Val468Ile glpK_p.Val468Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin glpK p.Val99Ala glpK_p.Val99Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA c.1005C>T gyrA_c.1005C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1011G>C gyrA_c.1011G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1020C>T gyrA_c.1020C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1026C>T gyrA_c.1026C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1029C>G gyrA_c.1029C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1036C>T gyrA_c.1036C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1041G>A gyrA_c.1041G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1041G>T gyrA_c.1041G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1044C>T gyrA_c.1044C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1047C>A gyrA_c.1047C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1053G>C gyrA_c.1053G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 5842 21461 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99990681638168 0.999663429698698 0.999988714832292 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.83678534748373 0.0311281139040964 35.2896458967866 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1059G>A gyrA_c.1059G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 0 NA NA NA 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.67374186922286 0.0467931454016956 287.712465214691 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1068G>C gyrA_c.1068G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1074G>A gyrA_c.1074G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1074G>C gyrA_c.1074G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1081C>T gyrA_c.1081C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1086C>T gyrA_c.1086C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1092T>C gyrA_c.1092T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.56487735727821 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.57852451631077 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1098T>C gyrA_c.1098T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1113C>T gyrA_c.1113C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 8 23 5835 21440 0.00136915967824747 0.00059128544285425 0.00269599843431209 0.998928388389321 0.998392487655117 0.999320572694302 0.258064516129032 0.118563995829551 0.446133934334896 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.27804478223613 0.494006023851506 2.96162593811123 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 12 2720 9627 0 0 0.00135528645033659 0.998755057578587 0.997826347023296 0.999356559855396 0 0 0.264648469397051 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.2747953585009 NA NA NA NA NA NA 81 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.111C>T gyrA_c.111C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1122G>A gyrA_c.1122G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1134C>G gyrA_c.1134C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1143G>C gyrA_c.1143G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1167C>T gyrA_c.1167C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1185T>C gyrA_c.1185T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1194C>A gyrA_c.1194C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1194C>G gyrA_c.1194C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1200G>C gyrA_c.1200G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1206C>T gyrA_c.1206C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1209G>A gyrA_c.1209G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1212C>G gyrA_c.1212C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 5 5842 21458 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.9997670409542 0.99945643574724 0.999924354643808 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.73461143444026 0.0155328045999449 6.56618384712436 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1218A>G gyrA_c.1218A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1224C>T gyrA_c.1224C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 8 5843 21455 0 0 0.000631133876986172 0.99962726552672 0.99926569731444 0.999839066414514 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.15187999193565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 5 2720 9634 0 0 0.00135528645033659 0.999481273991078 0.998789885214303 0.999831550309162 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.8675231049739 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1230G>A gyrA_c.1230G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1230G>T gyrA_c.1230G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1233G>A gyrA_c.1233G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 5843 21458 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.0087500478358 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.57852451631077 NA NA NA NA NA NA 19 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1239C>G gyrA_c.1239C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.123G>A gyrA_c.123G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1242C>G gyrA_c.1242C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1245T>C gyrA_c.1245T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1254G>T gyrA_c.1254G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1257C>G gyrA_c.1257C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1257C>T gyrA_c.1257C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1260A>C gyrA_c.1260A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1261C>T gyrA_c.1261C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.56487735727821 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.126G>A gyrA_c.126G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1278C>T gyrA_c.1278C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1293G>A gyrA_c.1293G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1296C>T gyrA_c.1296C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1302A>G gyrA_c.1302A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1308G>C gyrA_c.1308G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1318T>C gyrA_c.1318T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 7 5843 21456 0 0 0.000631133876986172 0.99967385733588 0.999328137654343 0.999868864001311 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.5485399472607 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 2720 9635 0 0 0.00135528645033659 0.999585019192862 0.998937828281888 0.999886920491758 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 5.36894442066688 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1323G>T gyrA_c.1323G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 10 5841 21453 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.9995340819084 0.999143327515781 0.999776552276323 0.166666666666666 0.0208625254600923 0.484137748685967 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.734565998972778 0.0782362563354321 3.44840829907378 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 3 2719 9636 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999688764394646 0.999090709558603 0.999935811136198 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.18131666053696 0.0224941657498392 14.7172429763561 NA NA NA NA NA NA 74 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1326C>T gyrA_c.1326C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.89146792489366 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 18.8709233025667 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1329G>A gyrA_c.1329G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 5 5841 21458 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.9997670409542 0.99945643574724 0.999924354643808 0.285714285714285 0.0366925661760855 0.709579136262657 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.46947440506762 0.139870903520674 8.97864690973746 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1335A>C gyrA_c.1335A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1338G>C gyrA_c.1338G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 18.8709233025667 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1344C>T gyrA_c.1344C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 9 5843 21454 0 0 0.000631133876986172 0.99958067371756 0.999204138016772 0.999808239967157 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.86084922251217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1356C>T gyrA_c.1356C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1359C>T gyrA_c.1359C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.135C>T gyrA_c.135C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1365G>A gyrA_c.1365G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1368C>G gyrA_c.1368C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1371A>G gyrA_c.1371A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1389C>T gyrA_c.1389C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1393C>T gyrA_c.1393C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 3 16 5840 21447 0.000513434879342803 0.000105895133877182 0.00149973424244328 0.99925453105344 0.998789686679379 0.999573841954248 0.157894736842105 0.0338262490017646 0.395784551266674 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.688580907534246 0.12853187780768 2.40678977518753 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 6 2719 9633 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999377528789293 0.998645638320949 0.999771530871485 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.590474439132033 0.0128360606385712 4.87020043259644 NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1401C>T gyrA_c.1401C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1404C>T gyrA_c.1404C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 18.8709233025667 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1410A>G gyrA_c.1410A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1416C>G gyrA_c.1416C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1416C>T gyrA_c.1416C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1422G>A gyrA_c.1422G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1434C>T gyrA_c.1434C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1440C>A gyrA_c.1440C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1440C>T gyrA_c.1440C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 21 5841 21442 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.999021572007641 0.998504755674517 0.999394238840018 0.0869565217391304 0.0107099660378758 0.280379335909411 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.34961397673262 0.0397326089520372 1.4309320293152 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 6 2719 9633 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999377528789293 0.998645638320949 0.999771530871485 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.590474439132033 0.0128360606385712 4.87020043259644 NA NA NA NA NA NA 113 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.144C>T gyrA_c.144C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1455A>G gyrA_c.1455A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1461G>C gyrA_c.1461G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1473C>A gyrA_c.1473C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1494C>T gyrA_c.1494C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 8 5842 21455 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99962726552672 0.99926569731444 0.999839066414514 0.111111111111111 0.00280913674659921 0.482496514917337 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.45906795617939 0.0103475211102756 3.425357676166 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.57852451631077 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1497C>T gyrA_c.1497C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1503C>T gyrA_c.1503C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1509A>T gyrA_c.1509A>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.150C>T gyrA_c.150C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1512C>T gyrA_c.1512C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1528T>C gyrA_c.1528T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1542G>A gyrA_c.1542G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1548C>G gyrA_c.1548C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1551T>G gyrA_c.1551T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1554C>G gyrA_c.1554C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1557T>G gyrA_c.1557T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1566A>G gyrA_c.1566A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1569G>C gyrA_c.1569G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.67374186922286 0.0467931454016956 287.712465214691 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1572A>C gyrA_c.1572A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.67374186922286 0.0467931454016956 287.712465214691 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1572A>G gyrA_c.1572A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1578C>T gyrA_c.1578C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1584C>T gyrA_c.1584C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1596T>C gyrA_c.1596T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 1 5841 21462 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99995340819084 0.99974043469953 0.999998820398217 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 7.3487416538264 0.382468755528661 432.333734199629 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 1 2718 9638 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 0.999896254798215 0.999422105789591 0.999997373402351 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 7.09197939661515 0.368993183584618 417.296682266591 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1597C>T gyrA_c.1597C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.159C>G gyrA_c.159C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.159C>T gyrA_c.159C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.15G>T gyrA_c.15G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.67374186922286 0.0467931454016956 287.712465214691 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1602T>C gyrA_c.1602T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.67374186922286 0.0467931454016956 287.712465214691 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1605C>G gyrA_c.1605C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1614A>G gyrA_c.1614A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.67374186922286 0.0467931454016956 287.712465214691 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1623C>G gyrA_c.1623C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1629C>G gyrA_c.1629C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1629C>T gyrA_c.1629C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 17 5843 21446 0 0 0.000631133876986172 0.99920793924428 0.99873213590018 0.999538529867378 0 0 0.195064322969093 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.889778498175186 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 7 2720 9632 0 0 0.00135528645033659 0.999273783587509 0.99850429270085 0.999707975074577 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.45859411933764 NA NA NA NA NA NA 44 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1632G>A gyrA_c.1632G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1641G>T gyrA_c.1641G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1644G>A gyrA_c.1644G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1645_1647delTTGinsCTC gyrA_c.1645_1647delTTGinsCTC 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1647G>A gyrA_c.1647G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 17 51 5826 21412 0.00290946431627588 0.00169575541737898 0.00465426040746216 0.997623817732842 0.996876928081474 0.998230280122265 0.25 0.152880495507176 0.369822350797951 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.22508296143723 0.662749352548229 2.15876653656066 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 6 19 2714 9620 0.00220588235294117 0.000809936709089192 0.00479504888600855 0.998028841166096 0.996923495333169 0.998812829432847 0.24 0.0935644393317428 0.451288017816686 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.11934220222627 0.365486539805213 2.91869032896247 NA NA NA NA NA NA 78 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1656C>T gyrA_c.1656C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 5843 21458 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.0087500478358 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.165G>T gyrA_c.165G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1665C>G gyrA_c.1665C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1671C>T gyrA_c.1671C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1677C>T gyrA_c.1677C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 28 5841 21435 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.998695429343521 0.998115079868827 0.999132952674816 0.0666666666666666 0.00817813446065631 0.220735401522961 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.262124880768948 0.0302546442062752 1.04004345905444 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 14 2720 9625 0 0 0.00135528645033659 0.998547567175018 0.997564264113055 0.999205721130751 0 0 0.231635761650116 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.06763707910471 NA NA NA NA NA NA 27 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1680G>C gyrA_c.1680G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1689C>T gyrA_c.1689C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.89146792489366 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.168C>G gyrA_c.168C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1692C>T gyrA_c.1692C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1704G>A gyrA_c.1704G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.89146792489366 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1713C>T gyrA_c.1713C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 5841 21463 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 1 0.999828143201531 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.689929368506768 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 2718 9639 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 1 0.999617369678334 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.665658435310444 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1716C>G gyrA_c.1716C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.67374186922286 0.0467931454016956 287.712465214691 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.171T>C gyrA_c.171T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1722A>C gyrA_c.1722A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1734G>A gyrA_c.1734G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1734G>C gyrA_c.1734G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1740G>A gyrA_c.1740G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.56487735727821 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1746C>T gyrA_c.1746C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 7 135 5836 21328 0.00119801471846654 0.000481795418920789 0.00246680058103687 0.993710105763406 0.992559453111956 0.994723771885037 0.0492957746478873 0.0200463949001538 0.0989296531356831 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.189495595664204 0.0747085173459365 0.401561323692343 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 2 37 2718 9602 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 0.996161427533976 0.994712877434656 0.997295894108395 0.0512820512820512 0.00627197209569041 0.173244781373605 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.190959171091621 0.0222852738608142 0.741158192070765 NA NA NA NA NA NA 173 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.174A>G gyrA_c.174A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1755C>G gyrA_c.1755C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1755C>T gyrA_c.1755C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1785C>T gyrA_c.1785C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1788G>A gyrA_c.1788G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 6 5842 21457 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99972044914504 0.999391635540124 0.999897403075094 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.612147666324318 0.0133096260827154 5.04744841661085 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1791C>T gyrA_c.1791C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1797G>C gyrA_c.1797G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1800A>G gyrA_c.1800A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1803C>G gyrA_c.1803C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1806C>T gyrA_c.1806C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1809G>A gyrA_c.1809G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1821C>G gyrA_c.1821C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1821C>T gyrA_c.1821C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 5 3 5838 21460 0.000855724798904672 0.00027790803803495 0.00199583691247191 0.99986022457252 0.999591571764338 0.999971174018896 0.625 0.244863216366551 0.914766585862746 NA NA NA NA NA NA NA NA NA NA NA NA False False 6.12652734954893 1.19146359990854 39.4644754416156 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 3 2 2717 9637 0.00110294117647058 0.000227510766880298 0.0032198465640147 0.999792509596431 0.999250676427901 0.999974870961701 0.6 0.146632799634673 0.947255049473683 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 5.3203901361796 0.609038002991023 63.7727801541732 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1824C>T gyrA_c.1824C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 3 9 5840 21454 0.000513434879342803 0.000105895133877182 0.00149973424244328 0.99958067371756 0.999204138016772 0.999808239967157 0.25 0.0548606445279927 0.571858461878189 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.22454337899543 0.213166253079868 4.90876155405007 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 2 2719 9637 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999792509596431 0.999250676427901 0.999974870961701 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.77215888194189 0.0300270423699391 34.0580978516331 NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1827C>A gyrA_c.1827C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 5 0 5838 21463 0.000855724798904672 0.00027790803803495 0.00199583691247191 1 0.999828143201531 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 3.36756214650866 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1836C>T gyrA_c.1836C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1842T>C gyrA_c.1842T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 120 1651 5723 19812 0.0205373951737121 0.0170561498312334 0.0245081437994751 0.923076923076923 0.919431095174438 0.926607667979624 0.0677583286278938 0.0564945439225455 0.0804783018032104 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.251616285165123 0.206784739831993 0.30377670658006 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 45 574 2675 9065 0.0165441176470588 0.0120923272749133 0.0220752909338182 0.940450254175744 0.935539412219652 0.94509279727352 0.0726978998384491 0.0535174321210642 0.096068623476986 NA NA NA NA NA NA NA NA NA NA NA NA False True 1 1 1 0 0 0 0 0.265671301572828 0.191042202616809 0.361444212718448 NA NA NA NA NA NA 3283 5) Not assoc w R Now listed Silent mutation no 0 +Levofloxacin gyrA c.1845C>T gyrA_c.1845C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1848C>T gyrA_c.1848C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1851C>T gyrA_c.1851C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.67374186922286 0.0467931454016956 287.712465214691 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1857C>T gyrA_c.1857C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.56487735727821 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 18.8709233025667 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1863G>A gyrA_c.1863G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.186C>G gyrA_c.186C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1881T>C gyrA_c.1881T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1884C>G gyrA_c.1884C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1899A>G gyrA_c.1899A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1902G>A gyrA_c.1902G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 18.8709233025667 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1905C>G gyrA_c.1905C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1905C>T gyrA_c.1905C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1917C>T gyrA_c.1917C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.56487735727821 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1920C>T gyrA_c.1920C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.89146792489366 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 18.8709233025667 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1926C>G gyrA_c.1926C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.192C>T gyrA_c.192C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1938C>T gyrA_c.1938C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1941A>T gyrA_c.1941A>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1959G>C gyrA_c.1959G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 120 5842 21343 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.994408982900806 0.993318176202961 0.995362380874617 0.00826446280991735 0.000209216193753886 0.0451861145207834 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.0304447677735935 0.000768807406568162 0.172985119210461 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 0 63 2720 9576 0 0 0.00135528645033659 0.993464052287581 0.991645327370637 0.994974050365158 0 0 0.0568723523320162 NA NA NA NA NA NA NA NA NA NA NA NA False True 1 1 1 0 0 0 0 0 0 0.212513306156826 NA NA NA NA NA NA 863 5) Not assoc w R Now listed Silent mutation no 0 +Levofloxacin gyrA c.195C>G gyrA_c.195C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.56487735727821 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 2720 9635 0 0 0.00135528645033659 0.999585019192862 0.998937828281888 0.999886920491758 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 5.36894442066688 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1962C>G gyrA_c.1962C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1962C>T gyrA_c.1962C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.89146792489366 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.57852451631077 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1971C>T gyrA_c.1971C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1975C>T gyrA_c.1975C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 5843 21458 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.0087500478358 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 5 2720 9634 0 0 0.00135528645033659 0.999481273991078 0.998789885214303 0.999831550309162 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.8675231049739 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1977G>C gyrA_c.1977G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1989G>A gyrA_c.1989G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1989G>C gyrA_c.1989G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1992G>A gyrA_c.1992G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1995T>C gyrA_c.1995T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1998G>A gyrA_c.1998G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.1998G>C gyrA_c.1998G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 3 5842 21460 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99986022457252 0.999591571764338 0.999971174018896 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.22446650690402 0.0233203404016305 15.2512395040111 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.-19G>T gyrA_c.-19G>T 1 upstream_gene_variant 7283 1 5 0 5 21 5 5822 21458 0.00359404415539962 0.00222610454413391 0.00548865843522298 0.9997670409542 0.99945643574724 0.999924354643808 0.807692307692307 0.606494472060678 0.934451891263217 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.02321254528707 0.591471949512721 245 2040 False False 15.4798351082102 5.67663114467695 52.5684661322164 0 0 0.000633409660734999 0.9997670409542 0.99945643574724 0.999924354643808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 6 3) Uncertain significance No change no 1 +Levofloxacin gyrA c.2007C>T gyrA_c.2007C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 3 5842 21460 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99986022457252 0.999591571764338 0.999971174018896 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.22446650690402 0.0233203404016305 15.2512395040111 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2014C>T gyrA_c.2014C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 5 5841 21458 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.9997670409542 0.99945643574724 0.999924354643808 0.285714285714285 0.0366925661760855 0.709579136262657 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.46947440506762 0.139870903520674 8.97864690973746 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 2 4 2718 9635 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 0.999585019192862 0.998937828281888 0.999886920491758 0.333333333333333 0.0432718682927417 0.777221904496487 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.77244297277409 0.160228512115282 12.3744222113045 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2016G>A gyrA_c.2016G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2017C>T gyrA_c.2017C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 18.8709233025667 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2022C>G gyrA_c.2022C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 0 5841 21463 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 1 0.999828143201531 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.689929368506768 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2043C>T gyrA_c.2043C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.89146792489366 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.204C>G gyrA_c.204C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.89146792489366 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2055G>T gyrA_c.2055G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.89146792489366 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2061C>T gyrA_c.2061C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.89146792489366 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.57852451631077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2067G>C gyrA_c.2067G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2076A>G gyrA_c.2076A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2082T>G gyrA_c.2082T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2085T>C gyrA_c.2085T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2094G>A gyrA_c.2094G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 10 5843 21453 0 0 0.000631133876986172 0.9995340819084 0.999143327515781 0.999776552276323 0 0 0.30849710781876 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.63855069807244 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 7 2720 9632 0 0 0.00135528645033659 0.999273783587509 0.99850429270085 0.999707975074577 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.45859411933764 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2094G>C gyrA_c.2094G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2106C>A gyrA_c.2106C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.67374186922286 0.0467931454016956 287.712465214691 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2106C>T gyrA_c.2106C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2115C>T gyrA_c.2115C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2128C>A gyrA_c.2128C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2136G>A gyrA_c.2136G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2139G>A gyrA_c.2139G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2140C>T gyrA_c.2140C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2142G>A gyrA_c.2142G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 4 103 5839 21360 0.000684579839123737 0.000186555462570677 0.00175186028923716 0.995201043656525 0.994182843889139 0.99608129785215 0.0373831775700934 0.010278000727758 0.0929547105493944 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.142064491027024 0.0379748515124 0.375151236392928 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 20 2719 9619 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.997925095964311 0.996797289142663 0.998732148393665 0.0476190476190476 0.00120488344836351 0.238159909936821 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.176884884148584 0.00426982181864695 1.1070521335791 NA NA NA NA NA NA 151 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2142G>C gyrA_c.2142G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2160C>T gyrA_c.2160C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2163C>A gyrA_c.2163C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2166T>C gyrA_c.2166T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2170C>T gyrA_c.2170C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2172G>A gyrA_c.2172G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2196G>A gyrA_c.2196G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2199A>G gyrA_c.2199A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2205C>T gyrA_c.2205C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 5843 21458 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.0087500478358 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 5 2720 9634 0 0 0.00135528645033659 0.999481273991078 0.998789885214303 0.999831550309162 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.8675231049739 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2214G>A gyrA_c.2214G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2223G>A gyrA_c.2223G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 16 5841 21447 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99925453105344 0.998789686679379 0.999573841954248 0.111111111111111 0.0137512156643644 0.347120438608672 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.458975346687211 0.0511857272786362 1.95310794665211 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 16 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.222C>G gyrA_c.222C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2235C>G gyrA_c.2235C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.89146792489366 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 18.8709233025667 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2238C>T gyrA_c.2238C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2247T>C gyrA_c.2247T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2251C>T gyrA_c.2251C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2256G>C gyrA_c.2256G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 24 5843 21439 0 0 0.000631133876986172 0.998881796580161 0.998336655864622 0.999283418690392 0 0 0.142473597722525 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.609852602793396 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 13 2720 9626 0 0 0.00135528645033659 0.998651312376802 0.997694807348449 0.999281691381267 0 0 0.24705263800047 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.16209042749756 NA NA NA NA NA NA 24 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2256G>T gyrA_c.2256G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2259C>G gyrA_c.2259C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.225G>C gyrA_c.225G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.225G>T gyrA_c.225G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2265C>T gyrA_c.2265C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 26 5842 21437 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.998788612961841 0.998225537528248 0.999208533933273 0.037037037037037 0.000937257091944708 0.189705617413044 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.141133173570694 0.00344565991027031 0.859512307759478 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 23 2720 9616 0 0 0.00135528645033659 0.997613860358958 0.996421757225608 0.998486809448329 0 0 0.148185128915224 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.615521952488556 NA NA NA NA NA NA 52 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2268C>T gyrA_c.2268C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2280C>T gyrA_c.2280C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2286G>A gyrA_c.2286G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2295G>T gyrA_c.2295G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 39 5841 21424 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.998182919442762 0.997516819563471 0.998707568843746 0.048780487804878 0.00596311824104283 0.16533335341783 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.188095645722764 0.0219980649034067 0.726970054196588 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 18 2720 9621 0 0 0.00135528645033659 0.99813258636788 0.997050280966737 0.998892888551341 0 0 0.185301968137852 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.805197693249005 NA NA NA NA NA NA 246 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2298G>A gyrA_c.2298G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.-22T>G gyrA_c.-22T>G 1 upstream_gene_variant 7280 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA c.2307C>T gyrA_c.2307C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2319G>A gyrA_c.2319G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 28 5842 21435 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.998695429343521 0.998115079868827 0.999132952674816 0.0344827586206896 0.000872646883579922 0.177644295488722 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.131040005868831 0.00320791542160456 0.792981880213172 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.231T>C gyrA_c.231T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 7 5843 21456 0 0 0.000631133876986172 0.99967385733588 0.999328137654343 0.999868864001311 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.5485399472607 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 2720 9635 0 0 0.00135528645033659 0.999585019192862 0.998937828281888 0.999886920491758 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 5.36894442066688 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.231T>G gyrA_c.231T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2322G>A gyrA_c.2322G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 5842 21461 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99990681638168 0.999663429698698 0.999988714832292 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.83678534748373 0.0311281139040964 35.2896458967866 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2322G>T gyrA_c.2322G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2328C>A gyrA_c.2328C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2328C>G gyrA_c.2328C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2328C>T gyrA_c.2328C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 4 5842 21459 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99981363276336 0.999522895233871 0.999949218940757 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.918307086614173 0.0186435710006194 9.27999188457764 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2352C>T gyrA_c.2352C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2355C>G gyrA_c.2355C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.56487735727821 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 21 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2355C>T gyrA_c.2355C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2358C>T gyrA_c.2358C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2382G>A gyrA_c.2382G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2391G>A gyrA_c.2391G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2397G>A gyrA_c.2397G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2400T>C gyrA_c.2400T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2403T>G gyrA_c.2403T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2406G>C gyrA_c.2406G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.240C>G gyrA_c.240C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2415T>C gyrA_c.2415T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2434C>T gyrA_c.2434C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 18.8709233025667 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2439G>A gyrA_c.2439G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2451C>G gyrA_c.2451C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2457C>T gyrA_c.2457C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 11 7 5832 21456 0.00188259455759027 0.000940147291275547 0.00336597924963922 0.99967385733588 0.999328137654343 0.999868864001311 0.611111111111111 0.357451205893062 0.827014145210248 NA NA NA NA NA NA NA NA NA NA NA NA False False 5.78130511463844 2.04553200704648 17.5934153665818 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 2 2719 9637 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999792509596431 0.999250676427901 0.999974870961701 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.77215888194189 0.0300270423699391 34.0580978516331 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.246C>T gyrA_c.246C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.67374186922286 0.0467931454016956 287.712465214691 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2472C>T gyrA_c.2472C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2475T>C gyrA_c.2475T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2481C>T gyrA_c.2481C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.2487C>T gyrA_c.2487C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 7 4 5836 21459 0.00119801471846654 0.000481795418920789 0.00246680058103687 0.99981363276336 0.999522895233871 0.999949218940757 0.636363636363636 0.307904715011677 0.890736556180901 NA NA NA NA NA NA NA NA NA NA NA NA False False 6.43475839616175 1.63501940239439 29.9893729894588 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.249C>T gyrA_c.249C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.-24C>G gyrA_c.-24C>G 1 upstream_gene_variant 7278 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA c.2511C>T gyrA_c.2511C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 18.8709233025667 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.252C>T gyrA_c.252C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 5840 21463 0.000513434879342803 0.000105895133877182 0.00149973424244328 1 0.999828143201531 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.51820267072123 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 2717 9639 0.00110294117647058 0.000227510766880298 0.0032198465640147 1 0.999617369678334 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.46497956541773 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.255C>T gyrA_c.255C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.258G>C gyrA_c.258G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.-25G>A gyrA_c.-25G>A 1 upstream_gene_variant 7277 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Levofloxacin gyrA c.-25G>C gyrA_c.-25G>C 1 upstream_gene_variant 7277 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA c.264C>T gyrA_c.264C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 5842 21461 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99990681638168 0.999663429698698 0.999988714832292 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.83678534748373 0.0311281139040964 35.2896458967866 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.267C>T gyrA_c.267C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.270G>C gyrA_c.270G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.273G>C gyrA_c.273G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.279C>T gyrA_c.279C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.-27C>G gyrA_c.-27C>G 1 upstream_gene_variant 7275 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA c.27C>T gyrA_c.27C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.286C>T gyrA_c.286C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.288G>C gyrA_c.288G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.291G>C gyrA_c.291G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.89146792489366 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.294C>T gyrA_c.294C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.300C>G gyrA_c.300C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.306C>G gyrA_c.306C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.306C>T gyrA_c.306C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.-30A>G gyrA_c.-30A>G 1 upstream_gene_variant 7272 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1416 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 765 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA c.312G>A gyrA_c.312G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.56487735727821 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.312G>T gyrA_c.312G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.315G>A gyrA_c.315G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 18.8709233025667 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.-32C>T gyrA_c.-32C>T 1 upstream_gene_variant 7270 1 14 2 12 3 12 5840 21451 0.000513434879342803 0.000105895133877182 0.00149973424244328 0.99944089829008 0.999023565718772 0.999711071680148 0.2 0.0433120051058366 0.480891133806853 0.142857142857142 0.0177945154831915 0.428129160909698 0.142857142857142 0.0177945154831915 0.428129160909698 0.61218607305936 0.0665274733058789 2.75107768955581 0.747592835625746 283 2040 False False 0.918279109589041 0.166228602662313 3.40423094203552 0.000342348510783978 4.14626822126113e-05 0.00123612765400647 0.99944089829008 0.999023565718772 0.999711071680148 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 2 9 3 9 2717 9630 0.00110294117647058 0.000227510766880298 0.0032198465640147 0.99906629318394 0.998228276906464 0.999572963722204 0.25 0.0548606445279927 0.571858461878189 0.181818181818181 0.0228311982999596 0.517755852360172 0.181818181818181 0.0228311982999596 0.517755852360172 0.787633419212366 0.0827661169136203 3.80838689803842 1 457.5 1102 False False 0 0 0 0 0 0 0 1.18145012881855 0.205587327807159 4.73819954830564 0.000735564545788893 8.90926957043619e-05 0.00265456039303256 0.99906629318394 0.998228276906464 0.999572963722204 8 3) Uncertain significance No change no 1 +Levofloxacin gyrA c.333C>T gyrA_c.333C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 31 5842 21432 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.998555653916041 0.997950487085694 0.999018432490374 0.03125 0.000790868597952557 0.162170994181511 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.118342149727777 0.00290704483216166 0.710434603781097 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 18.8709233025667 NA NA NA NA NA NA 59 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.342C>A gyrA_c.342C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.342C>T gyrA_c.342C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 18.8709233025667 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.-34C>T gyrA_c.-34C>T 1 upstream_gene_variant 7268 0 0 0 0 42 408 5801 21055 0.00718808831079924 0.00518531039519677 0.00970391458252417 0.98099054186274 0.979073797076919 0.982775392052849 0.0933333333333333 0.0680955225979968 0.124063965964759 NA NA NA 0 0 0.00900062091968978 NA NA NA NA NA NA False True 0.373629800135879 0.264894083682385 0.514875894512301 0 0 0.00063570191621744 0.98099054186274 0.979073797076919 0.982775392052849 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 14 118 2706 9521 0.00514705882352941 0.00281671585516267 0.00862082501157768 0.987758066189438 0.98535737379323 0.989856829483511 0.106060606060606 0.0592097622067436 0.171546603062967 NA NA NA 0 0 0.0307780960741445 NA NA NA NA NA NA False True 0 1 1 0 0 1 0 0.417446478008693 0.221089337990946 0.730106088005781 0 0 0.00136229350146798 0.987758066189438 0.98535737379323 0.989856829483511 367 Not assoc w R 5) Not assoc w R No change yes 1 +Levofloxacin gyrA c.351C>A gyrA_c.351C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.357A>C gyrA_c.357A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.372G>C gyrA_c.372G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.372G>T gyrA_c.372G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.375G>A gyrA_c.375G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.384G>A gyrA_c.384G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 10 5841 21453 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.9995340819084 0.999143327515781 0.999776552276323 0.166666666666666 0.0208625254600923 0.484137748685967 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.734565998972778 0.0782362563354321 3.44840829907378 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.57852451631077 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.390C>G gyrA_c.390C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 6 5843 21457 0 0 0.000631133876986172 0.99972044914504 0.999391635540124 0.999897403075094 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.1200699364824 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.390C>T gyrA_c.390C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.396C>T gyrA_c.396C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.399G>A gyrA_c.399G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.402G>A gyrA_c.402G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.420G>A gyrA_c.420G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.424C>T gyrA_c.424C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.444G>A gyrA_c.444G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.462T>C gyrA_c.462T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.471C>T gyrA_c.471C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.474C>T gyrA_c.474C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 16 5843 21447 0 0 0.000631133876986172 0.99925453105344 0.998789686679379 0.999573841954248 0 0 0.205907214207822 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.952125276634789 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 5 2720 9634 0 0 0.00135528645033659 0.999481273991078 0.998789885214303 0.999831550309162 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.8675231049739 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.498A>G gyrA_c.498A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.507G>T gyrA_c.507G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.513C>G gyrA_c.513C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.519G>A gyrA_c.519G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.89146792489366 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.520C>T gyrA_c.520C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.56487735727821 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.528C>T gyrA_c.528C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.531G>A gyrA_c.531G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.534A>G gyrA_c.534A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 12 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.537C>A gyrA_c.537C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.540C>T gyrA_c.540C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.549C>G gyrA_c.549C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.552C>T gyrA_c.552C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.89146792489366 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.561C>T gyrA_c.561C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 3 5842 21460 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99986022457252 0.999591571764338 0.999971174018896 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.22446650690402 0.0233203404016305 15.2512395040111 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 18.8709233025667 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.570G>A gyrA_c.570G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.57C>T gyrA_c.57C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.582G>A gyrA_c.582G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.67374186922286 0.0467931454016956 287.712465214691 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.591G>A gyrA_c.591G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 41 312 5802 21151 0.00701694335101831 0.00504004869113321 0.00950735573492145 0.985463355542095 0.983771407241674 0.987021875517967 0.116147308781869 0.0846514136079455 0.154254835020197 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.479051763759623 0.336718282810214 0.665885245554548 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 16 42 2704 9597 0.00588235294117647 0.00336589967267386 0.00953503998064353 0.995642701525054 0.994114713745524 0.996857891976728 0.275862068965517 0.166624976780153 0.408963552464563 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.35207100591715 0.708439180289823 2.46032005160182 NA NA NA NA NA NA 255 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.597C>T gyrA_c.597C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.612G>A gyrA_c.612G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.613C>T gyrA_c.613C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.615G>A gyrA_c.615G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.624C>T gyrA_c.624C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.627C>T gyrA_c.627C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.636A>G gyrA_c.636A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.651C>G gyrA_c.651C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 5841 21463 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 1 0.999828143201531 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.689929368506768 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.654G>C gyrA_c.654G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.657C>T gyrA_c.657C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 3 5842 21460 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99986022457252 0.999591571764338 0.999971174018896 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.22446650690402 0.0233203404016305 15.2512395040111 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.669T>C gyrA_c.669T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.66G>A gyrA_c.66G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.675C>T gyrA_c.675C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.681C>T gyrA_c.681C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.687G>C gyrA_c.687G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.6A>C gyrA_c.6A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.717C>T gyrA_c.717C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 7 5843 21456 0 0 0.000631133876986172 0.99967385733588 0.999328137654343 0.999868864001311 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.5485399472607 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 18.8709233025667 NA NA NA NA NA NA 13 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.729C>T gyrA_c.729C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.732C>T gyrA_c.732C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.735A>G gyrA_c.735A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.738T>C gyrA_c.738T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.741C>T gyrA_c.741C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 7 5843 21456 0 0 0.000631133876986172 0.99967385733588 0.999328137654343 0.999868864001311 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.5485399472607 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.744C>A gyrA_c.744C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.744C>T gyrA_c.744C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.750C>T gyrA_c.750C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.753T>C gyrA_c.753T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.780A>G gyrA_c.780A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.78C>G gyrA_c.78C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.89146792489366 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.805C>T gyrA_c.805C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.56487735727821 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.822G>A gyrA_c.822G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.825G>C gyrA_c.825G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.56487735727821 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.834C>T gyrA_c.834C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 114 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.840C>T gyrA_c.840C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.861C>T gyrA_c.861C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.879C>T gyrA_c.879C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.89146792489366 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.882C>G gyrA_c.882C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.882C>T gyrA_c.882C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.886C>T gyrA_c.886C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.888G>A gyrA_c.888G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.888G>C gyrA_c.888G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 5843 21458 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.0087500478358 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.891C>T gyrA_c.891C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.894C>T gyrA_c.894C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.897T>C gyrA_c.897T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.-8A>G gyrA_c.-8A>G 1 upstream_gene_variant 7294 1 3 0 3 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89146792489366 1 319.5 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA c.900C>G gyrA_c.900C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.89146792489366 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.90C>T gyrA_c.90C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.918T>C gyrA_c.918T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.930C>T gyrA_c.930C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.933T>G gyrA_c.933T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 11 5843 21452 0 0 0.000631133876986172 0.99948749009924 0.999083163687746 0.999744130025508 0 0 0.284914152918154 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.46336646580729 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.93T>C gyrA_c.93T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.945C>G gyrA_c.945C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.945C>T gyrA_c.945C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.948C>T gyrA_c.948C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.966G>C gyrA_c.966G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.984C>T gyrA_c.984C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 33 5841 21430 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.998462470297721 0.997841408000016 0.998941406264571 0.0571428571428571 0.00699676362830951 0.191571406345239 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.22235710987637 0.0258369514535671 0.869878092047047 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 11 2719 9628 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.998858802780371 0.997959002506684 0.999430185159088 0.0833333333333333 0.00210759323186022 0.384796165150944 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.321909793038884 0.00747960585022801 2.21688560239189 NA NA NA NA NA NA 209 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.987T>C gyrA_c.987T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.990C>T gyrA_c.990C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.993T>C gyrA_c.993T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.996C>T gyrA_c.996C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.89146792489366 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 18.8709233025667 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA c.999G>A gyrA_c.999G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrA p.Ala126Glu gyrA_p.Ala126Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 1 4 5842 21459 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99981363276336 0.999522895233871 0.999949218940757 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.56583008746417 0.58432028936451 238 2040 False False 0.918307086614173 0.0186435710006194 9.27999188457764 0 0 0.00063124187675269 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 2719 9637 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999792509596431 0.999250676427901 0.999974870961701 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8778635755656 1 457.5 1102 False False 0 0 0 0 0 0 0 1.77215888194189 0.0300270423699391 34.0580978516331 0 0 0.0013557845626193 0.999792509596431 0.999250676427901 0.999974870961701 1 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ala126Pro gyrA_p.Ala126Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 5842 21461 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99990681638168 0.999663429698698 0.999988714832292 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5709198500876 1 883 2040 False False 1.83678534748373 0.0311281139040964 35.2896458967866 0 0 0.00063124187675269 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 2719 9637 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999792509596431 0.999250676427901 0.999974870961701 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8778635755656 1 457.5 1102 False False 0 0 0 0 0 0 0 1.77215888194189 0.0300270423699391 34.0580978516331 0 0 0.0013557845626193 0.999792509596431 0.999250676427901 0.999974870961701 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Ala126Ser gyrA_p.Ala126Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 3.67374186922286 0.0467931454016956 287.712465214691 0.382182295738733 180 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ala186Thr gyrA_p.Ala186Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ala198Gly gyrA_p.Ala198Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ala210Val gyrA_p.Ala210Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.56487735727821 0.58431003819195 215.5 2040 False False 0 0 5.56487735727821 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ala288Asp gyrA_p.Ala288Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 21 5 16 13 18 5830 21445 0.00222488447715214 0.00118517251163732 0.00380161509892997 0.99916134743512 0.998674889990656 0.999502887997069 0.419354838709677 0.245475950738651 0.609240777507907 0.238095238095238 0.0821758755930225 0.471659827654621 0.217391304347826 0.0746034076488037 0.437030726236814 1.1494961406518 0.32919869781012 3.28552602442001 0.790424674216596 285 2040 False False 2.65661330283971 1.19591571022198 5.73814742677441 0.000856898029134533 0.000278289137826886 0.00199857171453263 0.99916134743512 0.998674889990656 0.999502887997069 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 13 3 10 8 11 2712 9628 0.00294117647058823 0.00127061997302132 0.00578702225151795 0.998858802780371 0.997959002506684 0.999430185159088 0.421052631578947 0.202521438977162 0.665002155988264 0.23076923076923 0.0503810734911515 0.53813153923404 0.214285714285714 0.0465792878898673 0.507975677048471 1.06504424778761 0.188214938305185 4.14056409530655 1 457.5 1102 False False 0 0 0 0 0 0 0 2.58192544918208 0.900519545536384 7.05371542031688 0.0011049723756906 0.000227929862054239 0.00322577000096904 0.998858802780371 0.997959002506684 0.999430185159088 14 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ala288Val gyrA_p.Ala288Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 5843 21457 0 0 0.000631133876986172 0.99972044914504 0.999391635540124 0.999897403075094 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.1200699364824 0.35257212959262 148.5 2040 False False 0 0 3.1200699364824 0 0 0.000631133876986172 0.99972044914504 0.999391635540124 0.999897403075094 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ala297Asp gyrA_p.Ala297Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Ala297Gly gyrA_p.Ala297Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ala322Glu gyrA_p.Ala322Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 8 5843 21455 0 0 0.000631133876986172 0.99962726552672 0.99926569731444 0.999839066414514 0 0 0.369416647552819 0 0 0.707598226178713 0 0 0.369416647552819 0 0 8.88939683047434 1 1414.5 2040 False False 0 0 2.15187999193565 0 0 0.000631133876986172 0.99962726552672 0.99926569731444 0.999839066414514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 4 2720 9635 0 0 0.00135528645033659 0.999585019192862 0.998937828281888 0.999886920491758 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 137.867760480519 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 5.36894442066688 0 0 0.00135528645033659 0.999585019192862 0.998937828281888 0.999886920491758 13 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ala322Ser gyrA_p.Ala322Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ala324Gly gyrA_p.Ala324Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ala324Val gyrA_p.Ala324Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ala347Ser gyrA_p.Ala347Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1496 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 815 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Ala347Thr gyrA_p.Ala347Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1497 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ala347Val gyrA_p.Ala347Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ala384Val gyrA_p.Ala384Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 117 1575 5726 19888 0.0200239602943693 0.0165877945116848 0.0239503331930194 0.926617900573079 0.923047911485439 0.930071821790863 0.0691489361702127 0.0575204186388108 0.0822972872572813 0.5 0.012579117093425 0.987420882906574 0.000634517766497461 1.6064469939824e-05 0.0035301833914572 3.47327977645826 0.0442396636582168 272.051649726892 0.397165103842111 NA NA False True 0.258015069108327 0.211484704976183 0.312290225911726 0.000174611489436004 4.42077038975741e-06 0.000972484736435151 0.926617900573079 0.923047911485439 0.930071821790863 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 2 1 1 43 534 2677 9105 0.0158088235294117 0.0114639325505792 0.0212358609302616 0.944600062247121 0.939845351380019 0.949083813969262 0.0745233968804159 0.0544550090612995 0.099072139871428 0.5 0.012579117093425 0.987420882906574 0.00186915887850467 4.73218858623463e-05 0.0103698997920744 3.40119536794919 0.0433129679493841 266.433987916366 0.402883620349175 NA NA False True 0 1 1 0 0 1 0 0.273879027756208 0.19530610751664 0.375335824043915 0.000373412994772218 9.45395381157867e-06 0.00207874907022529 0.944600062247121 0.939845351380019 0.949083813969262 2899 Not assoc w R 5) Not assoc w R No change yes 1 +Levofloxacin gyrA p.Ala400Val gyrA_p.Ala400Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Ala406Val gyrA_p.Ala406Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ala40Thr gyrA_p.Ala40Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89146792489366 1 319.5 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.57852451631077 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 8.57852451631077 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ala410Thr gyrA_p.Ala410Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ala410Val gyrA_p.Ala410Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Ala417Ser gyrA_p.Ala417Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Ala432Gly gyrA_p.Ala432Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1424 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ala432Val gyrA_p.Ala432Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ala434Glu gyrA_p.Ala434Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1429 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Ala445Val gyrA_p.Ala445Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 5 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ala456Gly gyrA_p.Ala456Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Ala456Val gyrA_p.Ala456Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 19 0 19 0 23 5843 21440 0 0 0.000631133876986172 0.998928388389321 0.998392487655117 0.999320572694302 0 0 0.148185128915224 0 0 0.176466911806965 0 0 0.148185128915224 0 0 0.786577925772272 0.0207943271758251 45 2040 False False 0 0 0.638595431674509 0 0 0.000631133876986172 0.998928388389321 0.998392487655117 0.999320572694302 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 0 11 0 13 2720 9626 0 0 0.00135528645033659 0.998651312376802 0.997694807348449 0.999281691381267 0 0 0.24705263800047 0 0 0.284914152918154 0 0 0.24705263800047 0 0 1.41113923454573 0.137146736279265 54 1102 False False 0 0 0 0 0 0 0 0 0 1.16209042749756 0 0 0.00135528645033659 0.998651312376802 0.997694807348449 0.999281691381267 35 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ala463Ser gyrA_p.Ala463Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 67 184 5776 21279 0.0114667123053226 0.00889728897188123 0.0145397404591057 0.991427107114569 0.990101537198679 0.992616861834945 0.266932270916334 0.213260693425408 0.32620024112087 NA NA NA 0 0 0.0198486278842017 NA NA NA NA NA NA False True 1.34147013880525 0.997051877978431 1.78641096766774 0 0 0.000638452517586748 0.991427107114569 0.990101537198679 0.992616861834945 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 14 58 2706 9581 0.00514705882352941 0.00281671585516267 0.00862082501157768 0.993982778296503 0.99222820228871 0.995427793866996 0.194444444444444 0.110583786678489 0.304668933298683 NA NA NA 0 0 0.0616210089039198 NA NA NA NA NA NA False True 0 1 1 0 0 1 0 0.854639753294084 0.439484595257099 1.55431014965761 0 0 0.00136229350146798 0.993982778296503 0.99222820228871 0.995427793866996 203 Not assoc w R 5) Not assoc w R No change yes 1 +Levofloxacin gyrA p.Ala500Glu gyrA_p.Ala500Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Ala501Val gyrA_p.Ala501Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ala512Gly gyrA_p.Ala512Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 142.964774304408 1 883 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0 0 0.00063124187675269 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ala512Ser gyrA_p.Ala512Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Ala512Thr gyrA_p.Ala512Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ala512Val gyrA_p.Ala512Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ala579Val gyrA_p.Ala579Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 5842 21461 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99990681638168 0.999663429698698 0.999988714832292 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 142.958128195713 1 883 2040 False False 1.83678534748373 0.0311281139040964 35.2896458967866 0 0 0.00063124187675269 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 2719 9637 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999792509596431 0.999250676427901 0.999974870961701 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 137.946920474639 1 457.5 1102 False False 0 0 0 0 0 0 0 1.77215888194189 0.0300270423699391 34.0580978516331 0 0 0.0013557845626193 0.999792509596431 0.999250676427901 0.999974870961701 7 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ala581Gly gyrA_p.Ala581Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Ala587Asp gyrA_p.Ala587Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ala591Val gyrA_p.Ala591Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 5841 21463 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 1 0.999828143201531 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1431 2040 False False Inf 0.689929368506768 Inf 0 0 0.000631349913487419 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Ala620Thr gyrA_p.Ala620Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1420 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 767 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ala626Val gyrA_p.Ala626Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 19.5666713375759 1 883 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ala662Val gyrA_p.Ala662Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Ala667Val gyrA_p.Ala667Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ala676Asp gyrA_p.Ala676Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ala676Val gyrA_p.Ala676Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 9 5 5834 21458 0.00154030463802841 0.000704559638966774 0.00292195530235611 0.9997670409542 0.99945643574724 0.999924354643808 0.642857142857142 0.351380110615991 0.87240157014084 0 0 0.602364635616474 0 0 0.521823750104981 0 0 5.57320398076882 0.584399837893263 243 2040 False False 6.62056907781967 1.99146706418478 25.1548308293539 0 0 0.000632107207336799 0.9997670409542 0.99945643574724 0.999924354643808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 2717 9639 0.00110294117647058 0.000227510766880298 0.0032198465640147 1 0.999617369678334 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 816 1102 False False 0 0 0 0 0 0 0 Inf 1.46497956541773 Inf 0 0 0.00135678188642832 1 0.999617369678334 1 3 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ala689Val gyrA_p.Ala689Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0941866911272879 Inf 0.213982274957884 105.5 2040 False False Inf 0.0941866911272879 Inf 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Ala696Thr gyrA_p.Ala696Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ala696Val gyrA_p.Ala696Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Ala71Thr gyrA_p.Ala71Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Ala736Thr gyrA_p.Ala736Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 3.67374186922286 0.0467931454016956 287.712465214691 0.382182295738733 180 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ala736Val gyrA_p.Ala736Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 8.89105370607792 1 883 2040 False False 0 0 5.56487735727821 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 18.8689657542533 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 8.57852451631077 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 9 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ala74Ser gyrA_p.Ala74Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 3 1 8 1 5835 21462 0.00136915967824747 0.00059128544285425 0.00269599843431209 0.99995340819084 0.99974043469953 0.999998820398217 0.888888888888888 0.517503485082663 0.9971908632534 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 11.0344473007712 0.88570426276271 577.296663944131 0.0328290306987114 51 2040 False False 29.4251928020565 3.94311058962229 1296.78360484201 0.000513874614594039 0.000105985839311804 0.00150101806688117 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 3 1 2717 9638 0.00110294117647058 0.000227510766880298 0.0032198465640147 0.999896254798215 0.999422105789591 0.999997373402351 0.75 0.194120449683243 0.99369053679029 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 3.5472948104527 0.0451737409712374 277.849162774449 0.391545712212849 99 1102 False False 0 0 0 0 0 0 0 10.6418844313581 0.853871105694195 556.864474256822 0.000367917586460632 9.31482342481655e-06 0.0020481824615316 0.999896254798215 0.999422105789591 0.999997373402351 5 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ala74Thr gyrA_p.Ala74Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1464 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ala74Val gyrA_p.Ala74Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Ala787Gly gyrA_p.Ala787Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 5843 21458 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.0087500478358 0.59157266040946 268 2040 False False 0 0 4.0087500478358 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ala788Val gyrA_p.Ala788Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1432 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 774 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Ala814Thr gyrA_p.Ala814Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 5842 21461 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99990681638168 0.999663429698698 0.999988714832292 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 142.958128195713 1 883 2040 False False 1.83678534748373 0.0311281139040964 35.2896458967866 0 0 0.00063124187675269 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 805 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 5 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ala90Glu gyrA_p.Ala90Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 142.964774304408 1 883 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0 0 0.00063124187675269 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Ala90Gly gyrA_p.Ala90Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 24 5842 21439 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.998881796580161 0.998336655864622 0.999283418690392 0.04 0.00101219969931084 0.203516913922414 NA NA NA 0 0 0.142473597722525 NA NA NA NA NA NA False True 0.152908535889535 0.00372146498074182 0.938118647915434 0 0 0.00063124187675269 0.998881796580161 0.998336655864622 0.999283418690392 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 1 23 2719 9616 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.997613860358958 0.996421757225608 0.998486809448329 0.0416666666666666 0.00105435244546974 0.211201683456973 NA NA NA 0 0 0.148185128915224 NA NA NA NA NA NA False True 0 0 0 0 0 1 0 0.153764971137086 0.00373516523343539 0.947865834043388 0 0 0.0013557845626193 0.997613860358958 0.996421757225608 0.998486809448329 10 Not assoc w RI Literature evidence (PMID 28137812) 4) Not assoc w R - Interim No change yes Lit. (PMID 28137812) 1 +Levofloxacin gyrA p.Ala90Trp gyrA_p.Ala90Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0941866911272879 Inf 0.213982274957884 105.5 2040 False False Inf 0.0941866911272879 Inf 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0908652957857324 Inf 0.220082530949106 80 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Ala90Val gyrA_p.Ala90Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1201 1065 136 1311 157 4532 21306 0.224371042272805 0.213728678187577 0.235289288354999 0.992685085961888 0.991452469604322 0.993781273315078 0.893051771117166 0.876108346572047 0.908403130373875 0.886761032472939 0.86746848740946 0.904135088642887 0.87152209492635 0.851454764682992 0.889781380906082 36.8148233476974 30.6904258486544 44.4183922935219 0 1.5 2040 True False 39.25681494932 33.1618601220682 46.8282902600974 0.190280507414686 0.180071302555741 0.200813627169115 0.992685085961888 0.991452469604322 0.993781273315078 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 557 496 61 612 71 2108 9568 0.225 0.20942572388514 0.241168246144751 0.992634090673306 0.990717861362013 0.994242811779389 0.896046852122986 0.870688774136053 0.917916068543047 0.89048473967684 0.86155219364903 0.91518781307605 0.874779541446208 0.8446896619962 0.900892313908828 36.9064609450337 28.1049243875837 49.1547479209836 2.04286838924395e-274 2 1102 True False 0 0 0 0 0 0 0 39.1240345297592 30.3744135055065 50.9562575868533 0.19047619047619 0.175556542435881 0.206095056091031 0.992634090673306 0.990717861362013 0.994242811779389 460 Assoc w R Assoc w R Marker of R 1) Assoc w R No change yes 1 +Levofloxacin gyrA p.Arg106Cys gyrA_p.Arg106Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 142.93371627475 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 810 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 2 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Arg143Lys gyrA_p.Arg143Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 3 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Arg14Leu gyrA_p.Arg14Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Arg195Gly gyrA_p.Arg195Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Arg222Trp gyrA_p.Arg222Trp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1501 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Arg252Gly gyrA_p.Arg252Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Arg252Leu gyrA_p.Arg252Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 7 77 5836 21386 0.00119801471846654 0.000481795418920789 0.00246680058103687 0.996412430694684 0.99551816444126 0.997167740535228 0.0833333333333333 0.0341623778539663 0.164189080270795 NA NA NA 0 0 0.046778068160404 NA NA NA NA NA NA False True 0.333136020935883 0.129548338889507 0.720418008986313 0 0 0.000631890652349158 0.996412430694684 0.99551816444126 0.997167740535228 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 0 26 2720 9613 0 0 0.00135528645033659 0.997302624753605 0.996050200704984 0.998237251556842 0 0 0.132274604497754 NA NA NA 0 0 0.132274604497754 NA NA NA NA NA NA False True 0 0 0 0 0 1 0 0 0 0.539193736763466 0 0 0.00135528645033659 0.997302624753605 0.996050200704984 0.998237251556842 94 Not assoc w R Previous WHO guidance 4) Not assoc w R - Interim DOWN from NotAwR to NotAwRI yes Prev. WHO 3 +Levofloxacin gyrA p.Arg252Pro gyrA_p.Arg252Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Arg254Cys gyrA_p.Arg254Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 14 0 14 0 14 5843 21449 0 0 0.000631133876986172 0.99934771467176 0.998905818000026 0.999643345117175 0 0 0.231635761650116 0 0 0.231635761650116 0 0 0.231635761650116 0 0 1.10705976842086 0.0511348574598736 59 2040 False False 0 0 1.10705976842086 0 0 0.000631133876986172 0.99934771467176 0.998905818000026 0.999643345117175 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 0 8 2720 9631 0 0 0.00135528645033659 0.999170038385724 0.99836530325407 0.99964161554927 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 2.07582396316403 0.213319169078315 62.5 1102 False False 0 0 0 0 0 0 0 0 0 2.07582396316403 0 0 0.00135528645033659 0.999170038385724 0.99836530325407 0.99964161554927 3 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Arg254Leu gyrA_p.Arg254Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1417 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Arg26Cys gyrA_p.Arg26Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Arg26His gyrA_p.Arg26His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Arg292Gly gyrA_p.Arg292Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 3 3 5840 21460 0.000513434879342803 0.000105895133877182 0.00149973424244328 0.99986022457252 0.999591571764338 0.999971174018896 0.5 0.118117248757025 0.881882751242974 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89603517522477 1 319.5 2040 False False 3.67465753424657 0.492014255735427 27.463249173756 0 0 0.000631457987209345 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.57852451631077 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 8.57852451631077 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 5 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Arg292Leu gyrA_p.Arg292Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1479 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Arg309Gln gyrA_p.Arg309Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 1 2 5842 21461 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99990681638168 0.999663429698698 0.999988714832292 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 1.83678534748373 0.0311281139040964 35.2896458967866 0.514394017317937 195.5 2040 False False 1.83678534748373 0.0311281139040964 35.2896458967866 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Arg309Trp gyrA_p.Arg309Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 5841 21463 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 1 0.999828143201531 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0942028134961591 Inf 0.213953488372093 90 2040 False False Inf 0.689929368506768 Inf 0.000171174255391989 4.33374753915718e-06 0.000953348826018904 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 2718 9639 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 1 0.999617369678334 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0908987145025996 Inf 0.220019420618223 71.5 1102 False False 0 0 0 0 0 0 0 Inf 0.665658435310444 Inf 0.000367782272894446 9.31139761383543e-06 0.00204742980952803 1 0.999617369678334 1 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Arg363Cys gyrA_p.Arg363Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 3.67374186922286 0.0467931454016956 287.712465214691 0.382182295738733 180 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 3.54468554615667 0.045140524816893 277.645286351599 0.391742630950597 101.5 1102 False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Arg375Gln gyrA_p.Arg375Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1480 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Arg376Leu gyrA_p.Arg376Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Arg380Gly gyrA_p.Arg380Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Arg387Gln gyrA_p.Arg387Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1492 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 813 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Arg392Cys gyrA_p.Arg392Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Arg392His gyrA_p.Arg392His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Arg409Gln gyrA_p.Arg409Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89146792489366 1 319.5 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 2 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Arg450Ser gyrA_p.Arg450Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 5840 21463 0.000513434879342803 0.000105895133877182 0.00149973424244328 1 0.999828143201531 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1475 2040 False False Inf 1.51820267072123 Inf 0 0 0.000631457987209345 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Arg480Cys gyrA_p.Arg480Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 142.93371627475 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Arg489Lys gyrA_p.Arg489Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Arg489Ser gyrA_p.Arg489Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Arg495Cys gyrA_p.Arg495Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 3 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Arg513Cys gyrA_p.Arg513Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Arg539Pro gyrA_p.Arg539Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Arg578Gln gyrA_p.Arg578Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 34 1 33 9 39 5834 21424 0.00154030463802841 0.000704559638966774 0.00292195530235611 0.998182919442762 0.997516819563471 0.998707568843746 0.1875 0.0894983818493728 0.326293023956713 0.0294117647058823 0.00074436423469026 0.153267669560317 0.025 0.000632744932049419 0.131585858482765 0.111280788689084 0.00273895323188718 0.665052091066435 0.00532629340182511 34 2040 False False 0.847446006170723 0.36076441439221 1.77989632746102 0.000171379605826906 4.33894653949314e-06 0.000954492069833317 0.998182919442762 0.997516819563471 0.998707568843746 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 27 1 26 7 30 2713 9609 0.0025735294117647 0.0010352988504908 0.00529522151968195 0.996887643946467 0.99555987534078 0.997899151272588 0.189189189189189 0.0796211208528768 0.351552378369254 0.037037037037037 0.000937257091944708 0.189705617413044 0.032258064516129 0.000816370071846613 0.167021116230227 0.136224446397686 0.00332532887981498 0.830071809952245 0.0181718223177648 27 1102 False False 0 0 0 0 0 0 0 0.826428308145963 0.306081119834152 1.92295426118304 0.000368459837877671 9.32855191409846e-06 0.00205119861131408 0.996887643946467 0.99555987534078 0.997899151272588 11 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Arg592Cys gyrA_p.Arg592Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1444 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 781 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Arg607Cys gyrA_p.Arg607Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Arg607His gyrA_p.Arg607His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 3 5842 21460 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99986022457252 0.999591571764338 0.999971174018896 0.25 0.00630946320970987 0.805879550316756 0 0 0.975 0 0 0.707598226178713 0 0 142.951482085634 1 883 2040 False False 1.22446650690402 0.0233203404016305 15.2512395040111 0 0 0.00063124187675269 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 811 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 13 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Arg615Gly gyrA_p.Arg615Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Arg615His gyrA_p.Arg615His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Arg615Leu gyrA_p.Arg615Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Arg65His gyrA_p.Arg65His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Arg68Cys gyrA_p.Arg68Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1498 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Arg68Gly gyrA_p.Arg68Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1446 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 783 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Arg718Cys gyrA_p.Arg718Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1484 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Arg758Trp gyrA_p.Arg758Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Arg789Gly gyrA_p.Arg789Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.56487735727821 0.58431003819195 215.5 2040 False False 0 0 5.56487735727821 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 16 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Arg789His gyrA_p.Arg789His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Asn193Ser gyrA_p.Asn193Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 63 0 63 5 63 5838 21400 0.000855724798904672 0.00027790803803495 0.00199583691247191 0.997064716022923 0.99624603753751 0.997743732465383 0.0735294117647058 0.0243052110506695 0.163312127345603 0 0 0.0568723523320162 0 0 0.0568723523320162 0 0 0.221143921402442 5.04648981537529e-07 18 2040 True False 0.290923723606149 0.0912713686929657 0.715979875528694 0 0 0.000631674245690789 0.997064716022923 0.99624603753751 0.997743732465383 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 16 0 16 0 16 2720 9623 0 0 0.00135528645033659 0.998340076771449 0.997305784636461 0.999050922126668 0 0 0.205907214207822 0 0 0.205907214207822 0 0 0.205907214207822 0 0 0.918144673960002 0.0313300053140298 32 1102 False False 0 0 0 0 0 0 0 0 0 0.918144673960002 0 0 0.00135528645033659 0.998340076771449 0.997305784636461 0.999050922126668 49 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Asn282Lys gyrA_p.Asn282Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 0 9 3 10 5840 21453 0.000513434879342803 0.000105895133877182 0.00149973424244328 0.9995340819084 0.999143327515781 0.999776552276323 0.23076923076923 0.0503810734911515 0.53813153923404 0 0 0.336267116879942 0 0 0.30849710781876 0 0 1.86171860538033 0.219673066191465 135 2040 False False 1.10203767123287 0.194826487732604 4.28214028428906 0 0 0.000631457987209345 0.9995340819084 0.999143327515781 0.999776552276323 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 2 4 2718 9635 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 0.999585019192862 0.998937828281888 0.999886920491758 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.37289646693013 0.582334203081714 125 1102 False False 0 0 0 0 0 0 0 1.77244297277409 0.160228512115282 12.3744222113045 0 0 0.00135628304118183 0.999585019192862 0.998937828281888 0.999886920491758 11 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Asn301Thr gyrA_p.Asn301Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1457 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Asn629Lys gyrA_p.Asn629Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Asn818Asp gyrA_p.Asn818Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.56487735727821 0.58431003819195 215.5 2040 False False 0 0 5.56487735727821 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Asn826Asp gyrA_p.Asn826Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 5843 21458 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.0087500478358 0.59157266040946 268 2040 False False 0 0 4.0087500478358 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 48 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Asn826His gyrA_p.Asn826His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Asn826Ile gyrA_p.Asn826Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1434 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Asn831Asp gyrA_p.Asn831Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Asn831Lys gyrA_p.Asn831Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 1 2 5842 21461 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99990681638168 0.999663429698698 0.999988714832292 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 1.83678534748373 0.0311281139040964 35.2896458967866 0.514394017317937 195.5 2040 False False 1.83678534748373 0.0311281139040964 35.2896458967866 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Asp111Gly gyrA_p.Asp111Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1470 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Asp199Tyr gyrA_p.Asp199Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Asp209Gly gyrA_p.Asp209Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Asp211Glu gyrA_p.Asp211Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 3.67374186922286 0.0467931454016956 287.712465214691 0.382182295738733 180 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Asp211Gly gyrA_p.Asp211Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Asp242Asn gyrA_p.Asp242Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Asp262Asn gyrA_p.Asp262Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Asp262Val gyrA_p.Asp262Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89146792489366 1 319.5 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Asp293Tyr gyrA_p.Asp293Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 8 5843 21455 0 0 0.000631133876986172 0.99962726552672 0.99926569731444 0.999839066414514 0 0 0.369416647552819 0 0 0.4592581264399 0 0 0.369416647552819 0 0 3.11977888146431 0.352564824108921 144 2040 False False 0 0 2.15187999193565 0 0 0.000631133876986172 0.99962726552672 0.99926569731444 0.999839066414514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 6 2720 9633 0 0 0.00135528645033659 0.999377528789293 0.998645638320949 0.999771530871485 0 0 0.4592581264399 0 0 0.602364635616474 0 0 0.4592581264399 0 0 5.36783015291786 0.582287019143315 110 1102 False False 0 0 0 0 0 0 0 0 0 3.00974784500922 0 0 0.00135528645033659 0.999377528789293 0.998645638320949 0.999771530871485 2 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Asp308_Val310delinsLeu gyrA_p.Asp308_Val310delinsLeu 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Asp367Glu gyrA_p.Asp367Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Asp367His gyrA_p.Asp367His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 142.93371627475 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Asp402Glu gyrA_p.Asp402Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Asp415Ala gyrA_p.Asp415Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1486 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 806 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Asp415Asn gyrA_p.Asp415Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Asp415Phe gyrA_p.Asp415Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Asp437Gly gyrA_p.Asp437Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1445 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 782 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Asp464Glu gyrA_p.Asp464Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 5 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Asp467His gyrA_p.Asp467His 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Asp481Ala gyrA_p.Asp481Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Asp481Glu gyrA_p.Asp481Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1471 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Asp481Gly gyrA_p.Asp481Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Asp488Ala gyrA_p.Asp488Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Asp488Glu gyrA_p.Asp488Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 7 5843 21456 0 0 0.000631133876986172 0.99967385733588 0.999328137654343 0.999868864001311 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 2.5485399472607 0.358203244449244 169.5 2040 False False 0 0 2.5485399472607 0 0 0.000631133876986172 0.99967385733588 0.999328137654343 0.999868864001311 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 2720 9634 0 0 0.00135528645033659 0.999481273991078 0.998789885214303 0.999831550309162 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 3.8675231049739 0.592777991359257 136 1102 False False 0 0 0 0 0 0 0 0 0 3.8675231049739 0 0 0.00135528645033659 0.999481273991078 0.998789885214303 0.999831550309162 22 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Asp493dup gyrA_p.Asp493dup 1 inframe_insertion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Asp493His gyrA_p.Asp493His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Asp504Glu gyrA_p.Asp504Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1421 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 768 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 7 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Asp507His gyrA_p.Asp507His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Asp509Asn gyrA_p.Asp509Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Asp515Asn gyrA_p.Asp515Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Asp515Glu gyrA_p.Asp515Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1454 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Asp532Asn gyrA_p.Asp532Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Asp532Glu gyrA_p.Asp532Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Asp552Gly gyrA_p.Asp552Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1476 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0 0 0.00063124187675269 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 803 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Asp583Glu gyrA_p.Asp583Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Asp639Ala gyrA_p.Asp639Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 0 9 5843 21454 0 0 0.000631133876986172 0.99958067371756 0.999204138016772 0.999808239967157 0 0 0.336267116879942 0 0 0.369416647552819 0 0 0.336267116879942 0 0 2.15177966489582 0.215640900670431 125 2040 False False 0 0 1.86084922251217 0 0 0.000631133876986172 0.99958067371756 0.999204138016772 0.999808239967157 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 7 2720 9632 0 0 0.00135528645033659 0.999273783587509 0.99850429270085 0.999707975074577 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 3.00943555955456 0.350000935648685 91.5 1102 False False 0 0 0 0 0 0 0 0 0 2.45859411933764 0 0 0.00135528645033659 0.999273783587509 0.99850429270085 0.999707975074577 110 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Asp639Gly gyrA_p.Asp639Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Asp641Glu gyrA_p.Asp641Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1451 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 787 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 1 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Asp641Tyr gyrA_p.Asp641Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Asp687Asn gyrA_p.Asp687Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Asp770Gly gyrA_p.Asp770Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1447 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Asp810Glu gyrA_p.Asp810Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1468 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Asp824Ala gyrA_p.Asp824Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Asp824Asn gyrA_p.Asp824Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1493 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Asp824Glu gyrA_p.Asp824Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1465 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 796 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Asp825Glu gyrA_p.Asp825Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1502 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Asp829Glu gyrA_p.Asp829Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 1 3 1 3 5842 21460 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99986022457252 0.999591571764338 0.999971174018896 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 1.22446650690402 0.0233203404016305 15.2512395040111 1 883 2040 False False 1.22446650690402 0.0233203404016305 15.2512395040111 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Asp834Asn gyrA_p.Asp834Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89146792489366 1 319.5 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.57852451631077 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 8.57852451631077 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 1 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Asp89Asn gyrA_p.Asp89Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 27 18 9 20 9 5823 21454 0.00342289919561868 0.00209201097268901 0.00528146372285452 0.99958067371756 0.999204138016772 0.999808239967157 0.689655172413793 0.491676646190009 0.847154060391368 0.666666666666666 0.460392713907742 0.834811820312684 0.666666666666666 0.460392713907742 0.834811820312684 7.36871028679374 3.14116523176556 18.6205691089346 5.32844293038029e-07 20 2040 True False 8.18745587421527 3.56143832437885 20.4230694381496 0.00308166409861325 0.00182738057425091 0.00486600152491021 0.99958067371756 0.999204138016772 0.999808239967157 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 16 11 5 13 5 2707 9634 0.00477941176470588 0.00254721544199456 0.00815907242338076 0.999481273991078 0.998789885214303 0.999831550309162 0.722222222222222 0.465198034416943 0.90305078747444 0.6875 0.413379363548641 0.889830045282882 0.6875 0.413379363548641 0.889830045282882 7.82962689323974 2.50468424768366 28.7769066491614 8.19942317700197e-05 14 1102 True False 0 0 0 0 0 0 0 9.25319541928334 3.09138303197164 33.1793539256257 0.00404709345106696 0.00202197288518257 0.00722980414879237 0.999481273991078 0.998789885214303 0.999831550309162 15 1) Assoc w R UP from Uncertain to AwR yes 4 +Levofloxacin gyrA p.Asp89Gly gyrA_p.Asp89Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 7 1 5836 21462 0.00119801471846654 0.000481795418920789 0.00246680058103687 0.99995340819084 0.99974043469953 0.999998820398217 0.875 0.473490329124793 0.996840276468748 1 0.158113883008419 1 0.666666666666666 0.0942993240502461 0.991596241340387 Inf 0.690488169887499 Inf 0.0457240191948423 55 2040 False False 25.7426319396847 3.30576787112106 1153.1231270102 0.000342583076396026 4.14910928831814e-05 0.00123697422784746 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 3 0 2717 9639 0.00110294117647058 0.000227510766880298 0.0032198465640147 1 0.999617369678334 1 1 0.292401773821286 1 1 0.025 1 1 0.025 1 Inf 0.0909321578101052 Inf 0.219956300072833 70 1102 False False 0 0 0 0 0 0 0 Inf 1.46497956541773 Inf 0.000367917586460632 9.31482342481655e-06 0.0020481824615316 1 0.999617369678334 1 6 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Asp94Ala gyrA_p.Asp94Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 386 313 73 441 81 5402 21382 0.0754749272633921 0.0688294404993764 0.082547883577526 0.996226063458044 0.995311492783365 0.997001853937918 0.844827586206896 0.810868699884354 0.874820051329958 0.810880829015544 0.768187736533455 0.848729095390197 0.794416243654822 0.751095996711446 0.833248482440336 16.9713043875175 13.0943398511835 22.2473941489665 9.6463171768925e-143 4 2040 True False 21.5500020568513 16.9371025017522 27.6980370527404 0.0547681539807524 0.0490102915683509 0.0609856681472508 0.996226063458044 0.995311492783365 0.997001853937918 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 198 166 32 227 34 2493 9605 0.0834558823529411 0.0733308867132631 0.0944874660866833 0.996472663139329 0.995074356290392 0.997556017240698 0.869731800766283 0.822745871835053 0.90807107941715 0.838383838383838 0.779574765207233 0.886751547419008 0.83 0.770628399606113 0.879304376763782 19.98633674288 13.5783532841876 30.2386792968202 3.51670879502888e-79 3 1102 True False 0 0 0 0 0 0 0 25.7230244685118 17.8233487768026 38.1395237214793 0.06242948476871 0.0535315794539521 0.0723049855573487 0.996472663139329 0.995074356290392 0.997556017240698 185 Assoc w R Assoc w R Marker of R 1) Assoc w R No change yes 1 +Levofloxacin gyrA p.Asp94Asn gyrA_p.Asp94Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 364 335 29 375 31 5468 21432 0.0641793599178504 0.0580287986176769 0.0707693195061778 0.998555653916041 0.997950487085694 0.999018432490374 0.923645320197044 0.893369668389142 0.947533538506864 0.92032967032967 0.887583513402185 0.945996063893388 0.915300546448087 0.881930071957323 0.941726039157173 45.2773503518906 30.921992457903 68.7164153277073 3.18761508645146e-189 3 2040 True False 47.4136913891969 32.7548980407834 70.8394124142443 0.057728760985697 0.051865426993065 0.0640414959830862 0.998555653916041 0.997950487085694 0.999018432490374 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 140 129 11 143 12 2577 9627 0.0525735294117647 0.0444878522924986 0.0616382210480865 0.998755057578587 0.997826347023296 0.999356559855396 0.92258064516129 0.868669373132651 0.959357238589206 0.921428571428571 0.863763569780707 0.960125244313346 0.914893617021276 0.856055415251108 0.955249557537372 43.8100328077045 23.6306051970647 89.8807872665653 4.22737465465372e-72 4 1102 True False 0 0 0 0 0 0 0 44.5175591773379 24.6518627705079 88.1998091880279 0.0476718403547671 0.0399522845491764 0.0563876248415805 0.998755057578587 0.997826347023296 0.999356559855396 139 Assoc w R Assoc w R Marker of R 1) Assoc w R No change yes 1 +Levofloxacin gyrA p.Asp94Gly gyrA_p.Asp94Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2055 1936 119 2128 131 3715 21332 0.364196474413828 0.351842842531029 0.376685846076613 0.993896473000046 0.992761434891511 0.994894415871431 0.942009738822487 0.931562810428516 0.95129073039495 0.942092457420924 0.931103718625364 0.951797549111426 0.93662312530237 0.92524447653986 0.94674303484263 93.418125473608 77.1952033432199 113.915707274705 0 1.5 2040 True False 93.2766810845242 77.7550022411165 112.656319189712 0.342594231109538 0.330216160866772 0.355135023127031 0.993896473000046 0.992761434891511 0.994894415871431 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 882 842 40 926 44 1794 9595 0.340441176470588 0.322629146378506 0.358597217787894 0.995435211121485 0.99387677647057 0.996681316805093 0.954639175257732 0.939580932133468 0.966850388834948 0.954648526077097 0.938753484972337 0.967405714878636 0.950338600451467 0.933902414558447 0.963687428996346 112.583472686733 81.6586695193959 158.681928168456 0 1 1102 True False 0 0 0 0 0 0 0 112.55916185264 82.8338809122634 157.162004619951 0.319423368740515 0.301643291393056 0.337605345332966 0.995435211121485 0.99387677647057 0.996681316805093 795 Assoc w R Assoc w R Marker of R 1) Assoc w R No change yes 1 +Levofloxacin gyrA p.Asp94His gyrA_p.Asp94His 1 missense_variant (see "Genomic_coordinates" sheet) 1 97 91 6 99 7 5744 21456 0.0169433510183125 0.0137914975424317 0.0205898090836794 0.99967385733588 0.999328137654343 0.999868864001311 0.933962264150943 0.868662490465208 0.973039229212038 0.938144329896907 0.870216339001163 0.976964002717552 0.928571428571428 0.858354753010355 0.970801020359171 56.6532033426183 25.0214620300333 158.647579906136 1.46735470826524e-53 7 2040 True False 52.8288897731794 24.6798022599562 134.984738655109 0.0155955441302485 0.0125746530388529 0.0191137737356668 0.99967385733588 0.999328137654343 0.999868864001311 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 40 36 4 41 4 2679 9635 0.0150735294117647 0.010838168209071 0.0203938837780686 0.999585019192862 0.998937828281888 0.999886920491758 0.911111111111111 0.78778826304566 0.97524704221653 0.9 0.7633626001239 0.97207458470578 0.9 0.7633626001239 0.97207458470578 32.3684210526315 11.5826099758881 124.892999689554 6.01923194841599e-20 7 1102 True False 0 0 0 0 0 0 0 36.8640350877193 13.329409635863 141.718361603932 0.0132596685082872 0.00930372410291778 0.0183101161148329 0.999585019192862 0.998937828281888 0.999886920491758 40 Assoc w R Assoc w R Marker of R 1) Assoc w R No change yes 1 +Levofloxacin gyrA p.Asp94Phe gyrA_p.Asp94Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 5841 21463 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 1 0.999828143201531 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.689929368506768 Inf 0.0457822541770358 56.5 2040 False False Inf 0.689929368506768 Inf 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0908652957857324 Inf 0.220082530949106 80 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Asp94Tyr gyrA_p.Asp94Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 224 205 19 229 19 5614 21444 0.0391921957898339 0.0343623105210338 0.0444888001139744 0.999114755625961 0.998617924918733 0.999466943572351 0.923387096774193 0.882943618354245 0.953245589534337 0.915178571428571 0.870709888749569 0.948159122942386 0.915178571428571 0.870709888749569 0.948159122942386 41.2129450809067 25.7005968422896 69.8555547400782 3.27287232288496e-114 5 2040 True False 46.0378752367202 28.7835068806681 78.0149211692111 0.0352294208626911 0.0306409484805645 0.0402911320370005 0.999114755625961 0.998617924918733 0.999466943572351 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 97 91 6 103 6 2617 9633 0.0378676470588235 0.0310119021077343 0.0457392775034959 0.999377528789293 0.998645638320949 0.999771530871485 0.944954128440367 0.884033468590945 0.979533776223176 0.938144329896907 0.870216339001163 0.976964002717552 0.938144329896907 0.870216339001163 0.976964002717552 55.8274742071073 24.6229583967979 156.734735106222 7.86463368294838e-53 6 1102 True False 0 0 0 0 0 0 0 63.1893389377149 28.0004059638719 176.429952097203 0.0336041358936484 0.0271404520865027 0.0410996330101721 0.999377528789293 0.998645638320949 0.999771530871485 95 Assoc w R Assoc w R Marker of R 1) Assoc w R No change yes 1 +Levofloxacin gyrA p.Asp94Val gyrA_p.Asp94Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 3 1 5840 21462 0.000513434879342803 0.000105895133877182 0.00149973424244328 0.99995340819084 0.99974043469953 0.999998820398217 0.75 0.194120449683243 0.99369053679029 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 3.675 0.0468091677661079 287.810746813822 0.382091781287142 173 2040 False False 11.025 0.884946155157416 576.804300084131 0.000171203561034069 4.33448949056051e-06 0.000953511978863128 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 2718 9638 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 0.999896254798215 0.999422105789591 0.999997373402351 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 138.011851332821 1 457.5 1102 False False 0 0 0 0 0 0 0 7.09197939661515 0.368993183584618 417.296682266591 0 0 0.00135628304118183 0.999896254798215 0.999422105789591 0.999997373402351 2 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Gln113Glu gyrA_p.Gln113Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 5843 21458 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.0087500478358 0.59157266040946 268 2040 False False 0 0 4.0087500478358 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 2720 9634 0 0 0.00135528645033659 0.999481273991078 0.998789885214303 0.999831550309162 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 3.8675231049739 0.592777991359257 136 1102 False False 0 0 0 0 0 0 0 0 0 3.8675231049739 0 0 0.00135528645033659 0.999481273991078 0.998789885214303 0.999831550309162 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Gln22Arg gyrA_p.Gln22Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Gln22His gyrA_p.Gln22His 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Gln238Arg gyrA_p.Gln238Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1439 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 777 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Gln238Glu gyrA_p.Gln238Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1455 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 789 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Gln25Glu gyrA_p.Gln25Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1487 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 807 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 3 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Gln277Arg gyrA_p.Gln277Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 1 8 5842 21455 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99962726552672 0.99926569731444 0.999839066414514 0.111111111111111 0.00280913674659921 0.482496514917337 0 0 0.4592581264399 0 0 0.369416647552819 0 0 3.12031349628375 0.352578235518943 156 2040 False False 0.45906795617939 0.0103475211102756 3.425357676166 0 0 0.00063124187675269 0.99962726552672 0.99926569731444 0.999839066414514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 2720 9635 0 0 0.00135528645033659 0.999585019192862 0.998937828281888 0.999886920491758 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.36894442066688 0.582297391718026 115.5 1102 False False 0 0 0 0 0 0 0 0 0 5.36894442066688 0 0 0.00135528645033659 0.999585019192862 0.998937828281888 0.999886920491758 7 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Gln290Arg gyrA_p.Gln290Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Gln290His gyrA_p.Gln290His 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Gln305Arg gyrA_p.Gln305Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Gln336Lys gyrA_p.Gln336Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Gln475Arg gyrA_p.Gln475Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0941866911272879 Inf 0.213982274957884 105.5 2040 False False Inf 0.0941866911272879 Inf 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0908652957857324 Inf 0.220082530949106 80 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Gln475Pro gyrA_p.Gln475Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Gln573Arg gyrA_p.Gln573Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Gln594Arg gyrA_p.Gln594Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1481 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Gln603His gyrA_p.Gln603His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Gln613Glu gyrA_p.Gln613Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 18 291 5825 21172 0.00308060927605682 0.00182675474076963 0.00486433743244719 0.986441783534454 0.984803682005644 0.987946100884129 0.058252427184466 0.034885855616163 0.0905035441144296 NA NA NA 0 0 0.0125965525269814 NA NA NA NA NA NA False True 0.224825450201318 0.131274990083672 0.362112849514561 0 0 0.000633083544451162 0.986441783534454 0.984803682005644 0.987946100884129 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 5 92 2715 9547 0.00183823529411764 0.000597130943349739 0.00428457163587036 0.990455441435833 0.988307114237388 0.99229899897792 0.0515463917525773 0.0169465018841938 0.116203303419031 NA NA NA 0 0 0.039303287739518 NA NA NA NA NA NA False True 0 1 1 0 0 1 0 0.19110817519417 0.0605570368535954 0.463089300287753 0 0 0.00135778067859282 0.990455441435833 0.988307114237388 0.99229899897792 122 Not assoc w R 5) Not assoc w R No change yes 1 +Levofloxacin gyrA p.Gln679His gyrA_p.Gln679His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Gln679Lys gyrA_p.Gln679Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Gln743His gyrA_p.Gln743His 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Gln790Glu gyrA_p.Gln790Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Gln797Pro gyrA_p.Gln797Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Glu140Gly gyrA_p.Glu140Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Glu144Gln gyrA_p.Glu144Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1472 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 801 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Glu147Asp gyrA_p.Glu147Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1503 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 817 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Glu148Asp gyrA_p.Glu148Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Glu214Asp gyrA_p.Glu214Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 1 6 3 6 5840 21457 0.000513434879342803 0.000105895133877182 0.00149973424244328 0.99972044914504 0.999391635540124 0.999897403075094 0.333333333333333 0.0748546314196918 0.700704943791459 0.142857142857142 0.00361029686190058 0.578723197043195 0.142857142857142 0.00361029686190058 0.578723197043195 0.612357305936073 0.0133141819541504 5.04917850934718 1 883 2040 False False 1.83707191780821 0.297196397505327 8.60517731171929 0.000171203561034069 4.33448949056051e-06 0.000953511978863128 0.99972044914504 0.999391635540124 0.999897403075094 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 3 2 2717 9637 0.00110294117647058 0.000227510766880298 0.0032198465640147 0.999792509596431 0.999250676427901 0.999974870961701 0.6 0.146632799634673 0.947255049473683 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 1.77346337872653 0.0300491374835646 34.0829058578214 0.525400730764486 108 1102 False False 0 0 0 0 0 0 0 5.3203901361796 0.609038002991023 63.7727801541732 0.000367917586460632 9.31482342481655e-06 0.0020481824615316 0.999792509596431 0.999250676427901 0.999974870961701 13 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Glu21Gln gyrA_p.Glu21Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1585 42 1543 5809 21326 34 137 0.994181071367448 0.991878037915125 0.995966955956002 0.0063830778549131 0.00536163908220529 0.00754144975223358 0.214077759351391 0.20920970681418 0.219007108430857 0.0264984227129337 0.0191629740820836 0.0356507152124477 0.00196555597154623 0.00141695577532068 0.00265594209947607 0.109679386984865 0.0658373522212128 0.184497587277202 2.47950677436745e-16 NA NA False True 1.09757352251601 0.748358132632863 1.65044106980373 0.552631578947368 0.434148822115836 0.666886892179078 0.0063830778549131 0.00536163908220529 0.00754144975223358 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 883 27 856 2707 9541 13 98 0.995220588235294 0.991840927576619 0.997452784558005 0.0101670297748729 0.00826157699021595 0.0123765550437168 0.221015676028739 0.213693439485619 0.228470718940255 0.0305775764439411 0.020245511195727 0.0441785008077622 0.00282190635451505 0.00186045243127358 0.00410308945333608 0.237778576563623 0.114339584756011 0.520362343068474 0.000187699366034078 NA NA False True 0 1 1 0 0 1 0 2.13883401997855 1.19201858793006 4.16639423253261 0.675 0.508705124521551 0.81427103323665 0.0101670297748729 0.00826157699021595 0.0123765550437168 24837 Not assoc w R 5) Not assoc w R No change yes 1 +Levofloxacin gyrA p.Glu21His gyrA_p.Glu21His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1459 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Glu289Asp gyrA_p.Glu289Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 1 4 15 8 5828 21455 0.00256717439671401 0.00143751780890291 0.00423063446053587 0.99962726552672 0.99926569731444 0.999839066414514 0.652173913043478 0.427343963036494 0.83623640162505 0.2 0.00505076337946806 0.716417936118089 0.111111111111111 0.00280913674659921 0.482496514917337 0.920341455044612 0.0186848657027272 9.30053532002871 1 883 2040 False False 6.90256091283459 2.74553491082687 18.8015936905506 0.000171556013038256 4.34341276400839e-06 0.000955474177698182 0.99962726552672 0.99926569731444 0.999839066414514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 5 4 2715 9635 0.00183823529411764 0.000597130943349739 0.00428457163587036 0.999585019192862 0.998937828281888 0.999886920491758 0.555555555555555 0.212008506778868 0.863004337734833 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.37883545753761 0.582389756045323 126 1102 False False 0 0 0 0 0 0 0 4.43600368324125 0.953932677572901 22.3656173042633 0 0 0.00135778067859282 0.999585019192862 0.998937828281888 0.999886920491758 5 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Glu289Gln gyrA_p.Glu289Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Glu303Lys gyrA_p.Glu303Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Glu317Asp gyrA_p.Glu317Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Glu317Gly gyrA_p.Glu317Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Glu386Val gyrA_p.Glu386Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Glu412Ala gyrA_p.Glu412Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Glu412Gly gyrA_p.Glu412Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Glu412Val gyrA_p.Glu412Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 5843 21458 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.0087500478358 0.59157266040946 268 2040 False False 0 0 4.0087500478358 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 2720 9634 0 0 0.00135528645033659 0.999481273991078 0.998789885214303 0.999831550309162 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 3.8675231049739 0.592777991359257 136 1102 False False 0 0 0 0 0 0 0 0 0 3.8675231049739 0 0 0.00135528645033659 0.999481273991078 0.998789885214303 0.999831550309162 1 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Glu429Ala gyrA_p.Glu429Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Glu459Ala gyrA_p.Glu459Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1466 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Glu459Lys gyrA_p.Glu459Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Glu466Ala gyrA_p.Glu466Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Glu485Ala gyrA_p.Glu485Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Glu508Ala gyrA_p.Glu508Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1435 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 775 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Glu514Gln gyrA_p.Glu514Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Glu605Gly gyrA_p.Glu605Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1458 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 792 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Glu719Gln gyrA_p.Glu719Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1440 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 778 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Glu738Asp gyrA_p.Glu738Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1490 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 812 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Glu739Gln gyrA_p.Glu739Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 1 4 1 4 5842 21459 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99981363276336 0.999522895233871 0.999949218940757 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 0.918307086614173 0.0186435710006194 9.27999188457764 1 319.5 2040 False False 0.918307086614173 0.0186435710006194 9.27999188457764 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 3 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Glu79Asp gyrA_p.Glu79Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 2 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Glu79Lys gyrA_p.Glu79Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Glu808Ala gyrA_p.Glu808Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Glu808Gln gyrA_p.Glu808Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Glu820_Ter839del gyrA_p.Glu820_Ter839del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Gly112Cys gyrA_p.Gly112Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Gly158Ser gyrA_p.Gly158Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 3.67374186922286 0.0467931454016956 287.712465214691 0.382182295738733 180 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Gly236Glu gyrA_p.Gly236Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1504 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 818 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Gly236Val gyrA_p.Gly236Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 2 2 5841 21461 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99990681638168 0.999663429698698 0.999988714832292 0.5 0.067585986488543 0.932414013511457 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5742605605944 1 883 2040 False False 3.67419962335216 0.266252080252227 50.6812073544246 0 0 0.000631349913487419 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Gly247Ser gyrA_p.Gly247Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 350 1501 5493 19962 0.059900735923327 0.0539515112087487 0.0662939263412355 0.930065694450915 0.926571819331568 0.933442540773049 0.189086980010804 0.171481772761989 0.207683102176541 NA NA NA 0 0 0.00245459709746666 NA NA NA NA NA NA False True 0.847387014155136 0.749303557974421 0.95634686368143 0 0 0.000671334622114525 0.930065694450915 0.926571819331568 0.933442540773049 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 136 680 2584 8959 0.05 0.0421138452949418 0.0588714505329759 0.929453262786596 0.924158496999654 0.934486709898804 0.166666666666666 0.141724635892442 0.194043142217439 NA NA NA 0 0 0.00541013494736573 NA NA NA NA NA NA False True 0 1 1 0 0 1 0 0.693421052631578 0.569536570411854 0.839419825088631 0 0 0.00142656641342895 0.929453262786596 0.924158496999654 0.934486709898804 1390 Not assoc w R 5) Not assoc w R No change yes 1 +Levofloxacin gyrA p.Gly265Asp gyrA_p.Gly265Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Gly294Ala gyrA_p.Gly294Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Gly311Ala gyrA_p.Gly311Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Gly351Ala gyrA_p.Gly351Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89146792489366 1 319.5 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 19 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Gly351Trp gyrA_p.Gly351Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89146792489366 1 319.5 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.57852451631077 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 8.57852451631077 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 4 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Gly477Arg gyrA_p.Gly477Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Gly477Glu gyrA_p.Gly477Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89146792489366 1 319.5 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Gly503Arg gyrA_p.Gly503Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89146792489366 1 319.5 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Gly503Val gyrA_p.Gly503Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1477 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Gly548Arg gyrA_p.Gly548Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Gly63Arg gyrA_p.Gly63Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Gly668Asp gyrA_p.Gly668Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 19 7 12 5472 19327 371 2136 0.936505219921273 0.929946189382645 0.942624123471389 0.0995201043656525 0.0955463043585267 0.103602738464017 0.220654058631396 0.215505642056997 0.225868014031269 0.368421052631578 0.162885872155099 0.616422076685594 0.000362056480811006 0.000145577477263086 0.000745831536349691 3.35849056603773 1.11189604632605 9.3151472609875 0.0157576590513879 NA NA False True 1.6300802321571 1.45309910447651 1.83237210257078 0.0185185185185185 0.00747701939795088 0.0377814707994407 0.0995201043656525 0.0955463043585267 0.103602738464017 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 11 1 10 2489 8388 231 1251 0.915073529411764 0.903960987063796 0.925282844500437 0.129785247432306 0.123136965354185 0.136658096755544 0.22883147926818 0.220964381769972 0.2368439820048 0.0909090909090909 0.00229897221381426 0.412779916988382 0.000119203719156037 3.01797231851816e-06 0.000663979672821812 0.541558441558441 0.0124291918080949 3.84054962305107 1 NA NA False True 0 1 1 0 0 1 0 1.60698493209222 1.38515472675541 1.87025235988823 0.0043103448275862 0.000109122528394633 0.0237804161643541 0.129785247432306 0.123136965354185 0.136658096755544 22090 Not assoc w R 5) Not assoc w R No change yes 1 +Levofloxacin gyrA p.Gly694Ala gyrA_p.Gly694Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Gly694Ser gyrA_p.Gly694Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1448 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 784 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Gly702Ser gyrA_p.Gly702Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Gly729Arg gyrA_p.Gly729Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 10 5842 21453 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.9995340819084 0.999143327515781 0.999776552276323 0.0909090909090909 0.00229897221381426 0.412779916988382 1 0.025 1 0.0909090909090909 0.00229897221381426 0.412779916988382 Inf 0.0941428077563651 Inf 0.214060668229777 123 2040 False False 0.367220130092434 0.00846382756918765 2.58216900423934 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.9995340819084 0.999143327515781 0.999776552276323 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 2720 9635 0 0 0.00135528645033659 0.999585019192862 0.998937828281888 0.999886920491758 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 800 1102 False False 0 0 0 0 0 0 0 0 0 5.36894442066688 0 0 0.00135528645033659 0.999585019192862 0.998937828281888 0.999886920491758 4 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Gly744Ala gyrA_p.Gly744Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Gly764Arg gyrA_p.Gly764Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Gly780Cys gyrA_p.Gly780Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1436 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 776 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Gly795Arg gyrA_p.Gly795Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Gly823Cys gyrA_p.Gly823Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Gly823Ser gyrA_p.Gly823Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Gly832Arg gyrA_p.Gly832Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Gly88Ala gyrA_p.Gly88Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 20 9 11 16 12 5827 21451 0.00273831935649495 0.00156597108493535 0.00444305999610189 0.99944089829008 0.999023565718772 0.999711071680148 0.571428571428571 0.371793628612095 0.755376063697853 0.45 0.230577896775924 0.684721866959451 0.428571428571428 0.21819685688513 0.659793690719725 3.01198184002371 1.10257653326052 7.99912740421234 0.0235585312077952 47 2040 False False 4.90841485040901 2.17713154260021 11.3760241601697 0.00154215215901302 0.00070540500572388 0.00292545761777444 0.99944089829008 0.999023565718772 0.999711071680148 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 4 3 9 3 2711 9636 0.00330882352941176 0.00151408667811563 0.00627184495549277 0.999688764394646 0.999090709558603 0.999935811136198 0.75 0.42814153812181 0.945139355472007 0.571428571428571 0.184051567640083 0.901011721557492 0.571428571428571 0.184051567640083 0.901011721557492 4.7392106233862 0.801103262300942 32.3677352358328 0.0459240456927622 35 1102 False False 0 0 0 0 0 0 0 10.6632239026189 2.65793272960087 61.2925189446036 0.00147329650092081 0.000401565006719416 0.00376789004987212 0.999688764394646 0.999090709558603 0.999935811136198 14 Assoc w R Assoc w RI Previous WHO guidance 2) Assoc w R - Interim No change yes Prev. WHO 1 +Levofloxacin gyrA p.Gly88Asn gyrA_p.Gly88Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1437 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Gly88Asp gyrA_p.Gly88Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0941866911272879 Inf 0.213982274957884 105.5 2040 False False Inf 0.0941866911272879 Inf 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0908652957857324 Inf 0.220082530949106 80 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Gly88Cys gyrA_p.Gly88Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 39 38 1 43 1 5800 21462 0.00735923327058018 0.00533088508192894 0.00990017065531279 0.99995340819084 0.99974043469953 0.999998820398217 0.977272727272727 0.879758417793652 0.999424760786636 0.974358974358974 0.865236078440502 0.999351036104518 0.974358974358974 0.865236078440502 0.999351036104518 140.613103448275 23.73830875048 5505.74840501857 9.82221909250633e-25 8 2040 True False 159.114827586206 27.0543304734618 6179.04675276901 0.00650907845152449 0.00461020838235318 0.00892337728377912 0.99995340819084 0.99974043469953 0.999998820398217 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 14 14 0 17 0 2703 9639 0.00625 0.00364494554148891 0.00998805433561389 1 0.999617369678334 1 1 0.804935677030906 1 1 0.768364238349883 1 1 0.768364238349883 1 Inf 11.8162087462073 Inf 6.01996712875067e-10 8 1102 True False 0 0 0 0 0 0 0 Inf 14.7001149034031 Inf 0.00515274199484725 0.00281982902636497 0.00863032711984745 1 0.999617369678334 1 24 Assoc w R Assoc w R 1) Assoc w R No change yes 1 +Levofloxacin gyrA p.His192Gln gyrA_p.His192Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1488 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.His334Tyr gyrA_p.His334Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.His368Gln gyrA_p.His368Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 5843 21458 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.0087500478358 0.59157266040946 268 2040 False False 0 0 4.0087500478358 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 9 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.His389Pro gyrA_p.His389Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 3 5842 21460 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99986022457252 0.999591571764338 0.999971174018896 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 19.5700107416863 1 883 2040 False False 1.22446650690402 0.0233203404016305 15.2512395040111 0 0 0.00063124187675269 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 137.896313968788 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.His490Arg gyrA_p.His490Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0941866911272879 Inf 0.213982274957884 105.5 2040 False False Inf 0.0941866911272879 Inf 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.His490Asn gyrA_p.His490Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.His490Tyr gyrA_p.His490Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1489 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 808 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.His52Tyr gyrA_p.His52Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 5840 21463 0.000513434879342803 0.000105895133877182 0.00149973424244328 1 0.999828143201531 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1425 2040 False False Inf 1.51820267072123 Inf 0 0 0.000631457987209345 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 2717 9639 0.00110294117647058 0.000227510766880298 0.0032198465640147 1 0.999617369678334 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 770 1102 False False 0 0 0 0 0 0 0 Inf 1.46497956541773 Inf 0 0 0.00135678188642832 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.His557Arg gyrA_p.His557Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1422 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.His70Arg gyrA_p.His70Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 4 2 12 3 5831 21460 0.00205373951737121 0.00106163336321942 0.00358471862336565 0.99986022457252 0.999591571764338 0.999971174018896 0.8 0.519108866193147 0.956687994894163 0.666666666666666 0.222778095503512 0.956728131707258 0.571428571428571 0.184051567640083 0.901011721557492 7.36065854913393 1.05451813521133 81.1939910539414 0.0215480037271053 46 2040 False False 14.7213170982678 3.97052263981514 81.2842024774905 0.000685518423307626 0.000186811278865517 0.00175426086946534 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 3 1 6 1 2714 9638 0.00220588235294117 0.000809936709089192 0.00479504888600855 0.999896254798215 0.999422105789591 0.999997373402351 0.857142857142857 0.421276802956804 0.996389703138099 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 10.6536477523949 0.854814454254633 557.477742261982 0.0354913908551371 34 1102 False False 0 0 0 0 0 0 0 21.3072955047899 2.58272233950832 975.045278123278 0.00110415899889584 0.000227762038838489 0.00322339801279947 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ile153Met gyrA_p.Ile153Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Ile153Val gyrA_p.Ile153Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Ile15Val gyrA_p.Ile15Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 8.89105370607792 1 883 2040 False False 0 0 5.56487735727821 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 137.896313968788 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 7 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ile189Met gyrA_p.Ile189Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89146792489366 1 319.5 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 1 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ile189Val gyrA_p.Ile189Val 1 missense_variant (see "Genomic_coordinates" sheet) 2 3 1 2 1 2 5842 21461 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99990681638168 0.999663429698698 0.999988714832292 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 1.83678534748373 0.0311281139040964 35.2896458967866 0.514394017317937 195.5 2040 False False 1.83678534748373 0.0311281139040964 35.2896458967866 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ile284Val gyrA_p.Ile284Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ile314Val gyrA_p.Ile314Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1460 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 794 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ile328Leu gyrA_p.Ile328Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1505 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 819 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 1 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ile348Val gyrA_p.Ile348Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ile390Thr gyrA_p.Ile390Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1499 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ile408Thr gyrA_p.Ile408Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1452 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 788 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ile408Val gyrA_p.Ile408Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 5843 21458 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.0087500478358 0.59157266040946 268 2040 False False 0 0 4.0087500478358 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 2720 9634 0 0 0.00135528645033659 0.999481273991078 0.998789885214303 0.999831550309162 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 3.8675231049739 0.592777991359257 136 1102 False False 0 0 0 0 0 0 0 0 0 3.8675231049739 0 0 0.00135528645033659 0.999481273991078 0.998789885214303 0.999831550309162 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Ile427Val gyrA_p.Ile427Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ile452Thr gyrA_p.Ile452Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Ile462Val gyrA_p.Ile462Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 3 8 5840 21455 0.000513434879342803 0.000105895133877182 0.00149973424244328 0.99962726552672 0.99926569731444 0.999839066414514 0.272727272727272 0.0602177341729066 0.609742559572421 0 0 0.369416647552819 0 0 0.369416647552819 0 0 2.15298610196793 0.215682022041068 133 2040 False False 1.37767551369863 0.235322166271864 5.74292468396216 0 0 0.000631457987209345 0.99962726552672 0.99926569731444 0.999839066414514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 3 2719 9636 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999688764394646 0.999090709558603 0.999935811136198 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.58167997356275 1 457.5 1102 False False 0 0 0 0 0 0 0 1.18131666053696 0.0224941657498392 14.7172429763561 0 0 0.0013557845626193 0.999688764394646 0.999090709558603 0.999935811136198 3 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ile468Val gyrA_p.Ile468Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ile478Thr gyrA_p.Ile478Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0941866911272879 Inf 0.213982274957884 105.5 2040 False False Inf 0.0941866911272879 Inf 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0908652957857324 Inf 0.220082530949106 80 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Ile478Val gyrA_p.Ile478Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1423 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 769 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Ile520Leu gyrA_p.Ile520Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1461 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ile554Val gyrA_p.Ile554Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Ile681Met gyrA_p.Ile681Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Ile707Val gyrA_p.Ile707Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 5841 21463 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 1 0.999828143201531 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.689929368506768 Inf 0.0457822541770358 56.5 2040 False False Inf 0.689929368506768 Inf 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ile815Met gyrA_p.Ile815Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1449 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 785 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ile92Val gyrA_p.Ile92Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1478 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 804 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Leu105Arg gyrA_p.Leu105Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 3 5842 21460 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99986022457252 0.999591571764338 0.999971174018896 0.25 0.00630946320970987 0.805879550316756 1 0.025 1 0.25 0.00630946320970987 0.805879550316756 Inf 0.0941735261160158 Inf 0.214005786909863 122 2040 False False 1.22446650690402 0.0233203404016305 15.2512395040111 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Leu12Phe gyrA_p.Leu12Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 142.93371627475 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Leu134Met gyrA_p.Leu134Met 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1462 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Leu142Val gyrA_p.Leu142Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 1 3 1 3 5842 21460 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99986022457252 0.999591571764338 0.999971174018896 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 1.22446650690402 0.0233203404016305 15.2512395040111 1 883 2040 False False 1.22446650690402 0.0233203404016305 15.2512395040111 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Leu173Val gyrA_p.Leu173Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Leu205Val gyrA_p.Leu205Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Leu274Phe gyrA_p.Leu274Phe 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1418 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 766 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Leu296Pro gyrA_p.Leu296Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 15 0 15 0 15 5843 21448 0 0 0.000631133876986172 0.9993011228626 0.9988475700008 0.999608792686571 0 0 0.218019360910534 0 0 0.218019360910534 0 0 0.218019360910534 0 0 1.02381522685458 0.0527637745358809 62 2040 False False 0 0 1.02381522685458 0 0 0.000631133876986172 0.9993011228626 0.9988475700008 0.999608792686571 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 2720 9635 0 0 0.00135528645033659 0.999585019192862 0.998937828281888 0.999886920491758 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.36894442066688 0.582297391718026 115.5 1102 False False 0 0 0 0 0 0 0 0 0 5.36894442066688 0 0 0.00135528645033659 0.999585019192862 0.998937828281888 0.999886920491758 48 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Leu346Val gyrA_p.Leu346Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 1 3 5 4 5838 21459 0.000855724798904672 0.00027790803803495 0.00199583691247191 0.99981363276336 0.999522895233871 0.999949218940757 0.555555555555555 0.212008506778868 0.863004337734833 0.25 0.00630946320970987 0.805879550316756 0.2 0.00505076337946806 0.716417936118089 1.22524837273038 0.0233352286504412 15.2609802422925 1 883 2040 False False 4.59468139773895 0.988535920059029 23.159204082702 0.000171262202431923 4.3359741557749e-06 0.000953838452137429 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 1 2718 9638 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 0.999896254798215 0.999422105789591 0.999997373402351 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 790 1102 False False 0 0 0 0 0 0 0 7.09197939661515 0.368993183584618 417.296682266591 0 0 0.00135628304118183 0.999896254798215 0.999422105789591 0.999997373402351 14 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Leu358Met gyrA_p.Leu358Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1485 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Leu398Phe gyrA_p.Leu398Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 2 6 5841 21457 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99972044914504 0.999391635540124 0.999897403075094 0.25 0.0318540262499442 0.650855794412824 0 0 0.521823750104981 0 0 0.4592581264399 0 0 4.00993607824757 0.591564219305067 253 2040 False False 1.22450493636934 0.120807800831081 6.84885887832521 0 0 0.000631349913487419 0.99972044914504 0.999391635540124 0.999897403075094 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 793 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 36 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Leu401Val gyrA_p.Leu401Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Leu425Phe gyrA_p.Leu425Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Leu455Arg gyrA_p.Leu455Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1494 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Leu455Val gyrA_p.Leu455Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 19.5657623867404 1 883 2040 False False 0 0 5.56487735727821 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Leu465Gln gyrA_p.Leu465Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Leu549Val gyrA_p.Leu549Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1438 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Leu566Trp gyrA_p.Leu566Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1441 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 779 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Leu653Val gyrA_p.Leu653Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1442 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Leu659Val gyrA_p.Leu659Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 5843 21458 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.0087500478358 0.59157266040946 268 2040 False False 0 0 4.0087500478358 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 2720 9634 0 0 0.00135528645033659 0.999481273991078 0.998789885214303 0.999831550309162 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 3.8675231049739 0.592777991359257 136 1102 False False 0 0 0 0 0 0 0 0 0 3.8675231049739 0 0 0.00135528645033659 0.999481273991078 0.998789885214303 0.999831550309162 1 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Leu671Val gyrA_p.Leu671Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Leu690Val gyrA_p.Leu690Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Leu711Met gyrA_p.Leu711Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 15 0 15 2 16 5841 21447 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99925453105344 0.998789686679379 0.999573841954248 0.111111111111111 0.0137512156643644 0.347120438608672 0 0 0.218019360910534 0 0 0.205907214207822 0 0 1.0241187655006 0.0527580946738117 61 2040 False False 0.458975346687211 0.0511857272786362 1.95310794665211 0 0 0.000631349913487419 0.99925453105344 0.998789686679379 0.999573841954248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 14 0 14 2 15 2718 9624 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 0.998443821973233 0.997434617850146 0.99912876560277 0.117647058823529 0.0145793168403025 0.36440916210125 0 0 0.231635761650116 0 0 0.218019360910534 0 0 1.06831213030183 0.0502874405434488 39 1102 False False 0 0 0 0 0 0 0 0.472111846946284 0.052361071946615 2.03224769623507 0 0 0.00135628304118183 0.998443821973233 0.997434617850146 0.99912876560277 15 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Leu724Val gyrA_p.Leu724Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Leu766Ser gyrA_p.Leu766Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1506 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Leu812Val gyrA_p.Leu812Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0941866911272879 Inf 0.213982274957884 105.5 2040 False False Inf 0.0941866911272879 Inf 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0908652957857324 Inf 0.220082530949106 80 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Lys224Glu gyrA_p.Lys224Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Lys319Asn gyrA_p.Lys319Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Lys319Glu gyrA_p.Lys319Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 5841 21462 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99995340819084 0.99974043469953 0.999998820398217 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 142.989195698265 1 319.5 2040 False False 7.3487416538264 0.382468755528661 432.333734199629 0 0 0.000631349913487419 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Lys333Arg gyrA_p.Lys333Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1463 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 795 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Lys333Asn gyrA_p.Lys333Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Lys633Arg gyrA_p.Lys633Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Lys636Asn gyrA_p.Lys636Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 19.5666713375759 1 883 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 137.896313968788 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 5 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Lys636Glu gyrA_p.Lys636Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 19.5666713375759 1 883 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Lys636Thr gyrA_p.Lys636Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 24 4 20 23 22 5820 21441 0.00393633407496149 0.00249688481990031 0.00590061412371869 0.998974980198481 0.998448516553724 0.999357517570523 0.511111111111111 0.35774038567003 0.662966251607206 0.166666666666666 0.0473536266072571 0.373841713488682 0.153846153846153 0.0435634765389238 0.348678785535361 0.73680412371134 0.183062450301038 2.20071559398339 0.803257673305118 286 2040 False False 3.85147610121836 2.05024394339329 7.25189965020434 0.000686813186813186 0.000187164173986795 0.00175757242990564 0.998974980198481 0.998448516553724 0.999357517570523 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 23 4 19 23 21 2697 9618 0.00845588235294117 0.00536763818922964 0.0126611112680921 0.997821350762527 0.99667162112269 0.998650891645602 0.522727272727272 0.366897516592834 0.675385783602917 0.17391304347826 0.0495076453057934 0.387811889954797 0.16 0.0453794523717095 0.360828454459272 0.750775715707511 0.185603703493841 2.26178757398756 0.801700364498397 143 1102 False False 0 0 0 0 0 0 0 3.90582128290693 2.06288363497055 7.4310665714091 0.0014809329877823 0.000403647161369911 0.00378739745269576 0.997821350762527 0.99667162112269 0.998650891645602 4 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Lys799Arg gyrA_p.Lys799Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1443 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 780 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Met139Val gyrA_p.Met139Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Met141Ile gyrA_p.Met141Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Met141Thr gyrA_p.Met141Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Met141Val gyrA_p.Met141Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Met220Arg gyrA_p.Met220Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1495 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 814 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 2 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Met24Ile gyrA_p.Met24Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Met24Val gyrA_p.Met24Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Met438Ile gyrA_p.Met438Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Met703Val gyrA_p.Met703Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1473 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Met804Val gyrA_p.Met804Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Met99Ile gyrA_p.Met99Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Met99Val gyrA_p.Met99Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Phe152Leu gyrA_p.Phe152Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 2 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Phe228Leu gyrA_p.Phe228Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Phe569Cys gyrA_p.Phe569Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Phe640Val gyrA_p.Phe640Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Phe64Leu gyrA_p.Phe64Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 142.93371627475 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 786 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Phe683Leu gyrA_p.Phe683Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Phe683Val gyrA_p.Phe683Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Phe705Leu gyrA_p.Phe705Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 1 6 5842 21457 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99972044914504 0.999391635540124 0.999897403075094 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.602364635616474 0 0 0.4592581264399 0 0 5.56531138221033 0.584314704024368 230 2040 False False 0.612147666324318 0.0133096260827154 5.04744841661085 0 0 0.00063124187675269 0.99972044914504 0.999391635540124 0.999897403075094 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 137.882037227845 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 8.57852451631077 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 3 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Pro102Leu gyrA_p.Pro102Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1500 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Pro108Ser gyrA_p.Pro108Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 2 4 2 4 5841 21459 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99981363276336 0.999522895233871 0.999949218940757 0.333333333333333 0.0432718682927417 0.777221904496487 0.333333333333333 0.0432718682927417 0.777221904496487 0.333333333333333 0.0432718682927417 0.777221904496487 1.83692860811504 0.166109303397098 12.8208569329986 0.614763901090506 281 2040 False False 1.83692860811504 0.166109303397098 12.8208569329986 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 2718 9639 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 1 0.999617369678334 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.665658435310444 Inf 0.0484224309476144 37 1102 False False 0 0 0 0 0 0 0 Inf 0.665658435310444 Inf 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 1 0.999617369678334 1 9 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Pro119Leu gyrA_p.Pro119Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Pro154Arg gyrA_p.Pro154Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 11 0 11 0 11 5843 21452 0 0 0.000631133876986172 0.99948749009924 0.999083163687746 0.999744130025508 0 0 0.284914152918154 0 0 0.284914152918154 0 0 0.284914152918154 0 0 1.46336646580729 0.135836573499167 82.5 2040 False False 0 0 1.46336646580729 0 0 0.000631133876986172 0.99948749009924 0.999083163687746 0.999744130025508 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 10 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Pro154Leu gyrA_p.Pro154Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Pro163Ala gyrA_p.Pro163Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1474 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 802 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Pro17Leu gyrA_p.Pro17Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Pro17Ser gyrA_p.Pro17Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 1 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Pro275Ala gyrA_p.Pro275Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 142.964774304408 1 883 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0 0 0.00063124187675269 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Pro472Ser gyrA_p.Pro472Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 32 1 31 5 32 5838 21431 0.000855724798904672 0.00027790803803495 0.00199583691247191 0.998509062106881 0.997895886619693 0.998979982994274 0.135135135135135 0.0453719923419939 0.287747797310572 0.03125 0.000790868597952557 0.162170994181511 0.0303030303030303 0.000766912075048109 0.157593972272496 0.118417708229729 0.00290889771499071 0.710888071051328 0.00812800421318135 36 2040 False False 0.573585774237752 0.174415908387236 1.48398965121674 0.000171262202431923 4.3359741557749e-06 0.000953838452137429 0.998509062106881 0.997895886619693 0.998979982994274 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 0 9 2720 9630 0 0 0.00135528645033659 0.99906629318394 0.998228276906464 0.999572963722204 0 0 0.336267116879942 0 0 0.369416647552819 0 0 0.336267116879942 0 0 2.07560843296841 0.213313822832226 60 1102 False False 0 0 0 0 0 0 0 0 0 1.79492921444566 0 0 0.00135528645033659 0.99906629318394 0.998228276906464 0.999572963722204 34 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Pro50Arg gyrA_p.Pro50Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1419 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Pro604Thr gyrA_p.Pro604Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89146792489366 1 319.5 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.57852451631077 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 8.57852451631077 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Pro621Leu gyrA_p.Pro621Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 4 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Pro66Ala gyrA_p.Pro66Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Pro741Ala gyrA_p.Pro741Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Pro7Leu gyrA_p.Pro7Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Pro7Ser gyrA_p.Pro7Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Pro8Ala gyrA_p.Pro8Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 26 0 26 1 29 5842 21434 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.998648837534361 0.99806007718306 0.999094924371041 0.0333333333333333 0.000843570926630479 0.172169455633412 0 0 0.132274604497754 0 0 0.119444869069502 0 0 0.559518471310331 0.00308168486278747 31 2040 False False 0.126515482416272 0.00310093602436116 0.76342470801201 0 0 0.00063124187675269 0.998648837534361 0.99806007718306 0.999094924371041 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 0 8 2720 9631 0 0 0.00135528645033659 0.999170038385724 0.99836530325407 0.99964161554927 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 2.07582396316403 0.213319169078315 62.5 1102 False False 0 0 0 0 0 0 0 0 0 2.07582396316403 0 0 0.00135528645033659 0.999170038385724 0.99836530325407 0.99964161554927 31 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Pro8Leu gyrA_p.Pro8Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0941866911272879 Inf 0.213982274957884 105.5 2040 False False Inf 0.0941866911272879 Inf 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0908652957857324 Inf 0.220082530949106 80 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Ser104Leu gyrA_p.Ser104Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ser168Asn gyrA_p.Ser168Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ser168Thr gyrA_p.Ser168Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1426 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 771 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ser237Ala gyrA_p.Ser237Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 5842 21461 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99990681638168 0.999663429698698 0.999988714832292 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 142.958128195713 1 883 2040 False False 1.83678534748373 0.0311281139040964 35.2896458967866 0 0 0.00063124187675269 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 2719 9637 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999792509596431 0.999250676427901 0.999974870961701 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 137.946920474639 1 457.5 1102 False False 0 0 0 0 0 0 0 1.77215888194189 0.0300270423699391 34.0580978516331 0 0 0.0013557845626193 0.999792509596431 0.999250676427901 0.999974870961701 9 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ser237Pro gyrA_p.Ser237Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 19.5666713375759 1 883 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 809 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Ser250Ala gyrA_p.Ser250Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 25 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Ser250Tyr gyrA_p.Ser250Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Ser34Arg gyrA_p.Ser34Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Ser411Ala gyrA_p.Ser411Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Ser506Asn gyrA_p.Ser506Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ser536Arg gyrA_p.Ser536Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.56487735727821 0.58431003819195 215.5 2040 False False 0 0 5.56487735727821 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 3 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ser62Phe gyrA_p.Ser62Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ser642Cys gyrA_p.Ser642Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ser698Leu gyrA_p.Ser698Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 5843 21458 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.0087500478358 0.59157266040946 268 2040 False False 0 0 4.0087500478358 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ser69Gly gyrA_p.Ser69Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 1 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ser728Ala gyrA_p.Ser728Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ser772Arg gyrA_p.Ser772Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Ser91Pro gyrA_p.Ser91Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 277 232 45 274 51 5569 21412 0.046893718979976 0.0416148605480187 0.0526306718742822 0.997623817732842 0.996876928081474 0.998230280122265 0.843076923076923 0.798890255734158 0.880873883480645 0.83754512635379 0.788728022323004 0.878968593404465 0.819787985865724 0.76995845748297 0.862777675858142 19.8223658745835 14.3269769932049 27.9538417846493 1.55815944336524e-110 6 2040 True False 20.6566743774184 15.2446265914218 28.4732158124929 0.0399931046371315 0.035097236605041 0.0453581906631266 0.997623817732842 0.996876928081474 0.998230280122265 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 149 125 24 148 26 2572 9613 0.0544117647058823 0.0461870266416856 0.0636110637754507 0.997302624753605 0.996050200704984 0.998237251556842 0.850574712643678 0.788771971891656 0.900009618480803 0.838926174496644 0.769880873028175 0.893986731011134 0.827814569536423 0.757976559912871 0.8843318924378 19.4664495852773 12.4654802807512 31.5970312678092 3.5150733933992e-59 5 1102 True False 0 0 0 0 0 0 0 21.2753319775092 13.9161150439262 33.7070178450735 0.0463477938450129 0.038724288020008 0.0549742145789656 0.997302624753605 0.996050200704984 0.998237251556842 130 Assoc w R Assoc w R Marker of R 1) Assoc w R No change yes 1 +Levofloxacin gyrA p.Ser95Ala gyrA_p.Ser95Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 2 1 6 3 5837 21460 0.0010268697586856 0.000376933373413978 0.00223371319186393 0.99986022457252 0.999591571764338 0.999971174018896 0.666666666666666 0.29929505620854 0.925145368580308 0.666666666666666 0.0942993240502461 0.991596241340387 0.4 0.0527449505263169 0.853367200365326 7.35309234195648 0.38269531991976 432.588883146336 0.117658464418904 76 2040 False False 7.35309234195648 1.5697311319764 45.5002299892126 0.000342524404863846 4.14839865660465e-05 0.00123676247569629 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 2 1 4 2 2716 9637 0.00147058823529411 0.000400826576335422 0.00376097173045195 0.999792509596431 0.999250676427901 0.999974870961701 0.666666666666666 0.222778095503512 0.956728131707258 0.666666666666666 0.0942993240502461 0.991596241340387 0.5 0.067585986488543 0.932414013511457 7.09646539027982 0.369226447146645 417.559842381681 0.123853999771462 45 1102 False False 0 0 0 0 0 0 0 7.09646539027982 1.01621827488765 78.388010425549 0.000735835172921265 8.91254790451644e-05 0.00265553611379101 0.999792509596431 0.999250676427901 0.999974870961701 3 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Ser95Thr gyrA_p.Ser95Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 23 1 22 5265 19462 578 2001 0.90107821324662 0.893135968720515 0.908617354419062 0.0932302101290593 0.0893723686612264 0.0971986199191968 0.212925142556719 0.207836374584699 0.218081463793171 0.0434782608695652 0.0011001686304415 0.21948660745348 5.13795406669064e-05 1.30081649886323e-06 0.000286234859800286 0.15736080528468 0.00381020232267071 0.978169639778573 0.0412386945466046 NA NA False True 0.936548251779085 0.849025208410579 1.03424658900315 0.00172711571675302 4.37258280815134e-05 0.00958496876838432 0.0932302101290593 0.0893723686612264 0.0971986199191968 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 18 0 18 2390 8486 330 1153 0.878676470588235 0.865813526563259 0.890718077496323 0.119618217657433 0.11320360540229 0.126263647021377 0.219749908054431 0.211997690250775 0.227652431259241 0 0 0.185301968137852 0 0 0.000434607328425058 0 0 0.800275450560517 0.0189879148975745 NA NA False True 0 1 1 0 0 1 0 0.984034309629407 0.862525898621618 1.12475996262044 0 0 0.0111161761772372 0.119618217657433 0.11320360540229 0.126263647021377 22132 Not assoc w R Not assoc w R 5) Not assoc w R No change yes 1 +Levofloxacin gyrA p.Ter839delins??? gyrA_p.Ter839delins??? 1 stop_lost (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1427 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 772 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Ter839ext*? gyrA_p.Ter839ext*? 1 stop_lost (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1467 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 797 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 5 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Thr230Ser gyrA_p.Thr230Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Thr246Ala gyrA_p.Thr246Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1469 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 799 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Thr267Ile gyrA_p.Thr267Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 13 0 13 6 13 5837 21450 0.0010268697586856 0.000376933373413978 0.00223371319186393 0.99939430648092 0.998964468353895 0.999677455549724 0.31578947368421 0.125760635872983 0.56550156884615 0 0 0.24705263800047 0 0 0.24705263800047 0 0 1.20621176155705 0.0844521703054379 73 2040 False False 1.69607675175603 0.528382615171572 4.78467712153976 0 0 0.000631782430488341 0.99939430648092 0.998964468353895 0.999677455549724 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 137.961202437293 1 457.5 1102 False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 0 0 0.0013557845626193 0.999896254798215 0.999422105789591 0.999997373402351 20 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Thr272Ile gyrA_p.Thr272Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 1 7 5842 21456 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99967385733588 0.999328137654343 0.999868864001311 0.125 0.0031597235312519 0.526509670875206 0 0 0.4592581264399 0 0 0.409616397225003 0 0 3.12045904890713 0.352581891707473 158 2040 False False 0.524673546241502 0.0116431407170618 4.08534979936462 0 0 0.00063124187675269 0.99967385733588 0.999328137654343 0.999868864001311 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.57852451631077 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 8.57852451631077 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 4 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Thr339Ser gyrA_p.Thr339Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Thr355Ala gyrA_p.Thr355Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1430 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 773 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Thr355Met gyrA_p.Thr355Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Thr355Ser gyrA_p.Thr355Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 9 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Thr377Ile gyrA_p.Thr377Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 1 5 5842 21458 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.9997670409542 0.99945643574724 0.999924354643808 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.00943637980382 0.591567772689754 255 2040 False False 0.73461143444026 0.0155328045999449 6.56618384712436 0 0 0.00063124187675269 0.9997670409542 0.99945643574724 0.999924354643808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 5 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Thr378Asn gyrA_p.Thr378Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Thr378Ile gyrA_p.Thr378Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Thr413Ala gyrA_p.Thr413Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1456 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 791 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Thr563Ser gyrA_p.Thr563Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Thr572Asn gyrA_p.Thr572Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 6 5843 21457 0 0 0.000631133876986172 0.99972044914504 0.999391635540124 0.999897403075094 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1433 2040 False False 0 0 3.1200699364824 0 0 0.000631133876986172 0.99972044914504 0.999391635540124 0.999897403075094 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Thr590Ala gyrA_p.Thr590Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 142.964774304408 1 883 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0 0 0.00063124187675269 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Thr590Met gyrA_p.Thr590Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Thr5Ala gyrA_p.Thr5Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 11 1 10 3 10 5840 21453 0.000513434879342803 0.000105895133877182 0.00149973424244328 0.9995340819084 0.999143327515781 0.999776552276323 0.23076923076923 0.0503810734911515 0.53813153923404 0.0909090909090909 0.00229897221381426 0.412779916988382 0.0909090909090909 0.00229897221381426 0.412779916988382 0.367345890410958 0.00846672419805312 2.58305729799984 0.475967628691884 188 2040 False False 1.10203767123287 0.194826487732604 4.28214028428906 0.000171203561034069 4.33448949056051e-06 0.000953511978863128 0.9995340819084 0.999143327515781 0.999776552276323 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.57852451631077 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 8.57852451631077 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 13 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Thr638Asn gyrA_p.Thr638Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Thr638Ile gyrA_p.Thr638Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89146792489366 1 319.5 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Thr686Ser gyrA_p.Thr686Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1482 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Thr697Ala gyrA_p.Thr697Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Thr735Ser gyrA_p.Thr735Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 2 1 5841 21462 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99995340819084 0.99974043469953 0.999998820398217 0.666666666666666 0.0942993240502461 0.991596241340387 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 3.6743708269132 0.0468011552125941 287.761597623244 0.382137040999189 174 2040 False False 7.3487416538264 0.382468755528661 432.333734199629 0.000171174255391989 4.33374753915718e-06 0.000953348826018904 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 798 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Thr80Ala gyrA_p.Thr80Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 78 5839 21385 0.000684579839123737 0.000186555462570677 0.00175186028923716 0.996365838885524 0.995466447915492 0.997126318386567 0.048780487804878 0.0134490336528281 0.120211762214449 NA NA NA 0 0 0.0461924203280487 NA NA NA NA NA NA False True 0.187817548667009 0.0499392156253838 0.500760700747156 0 0 0.000631566097937464 0.996365838885524 0.995466447915492 0.997126318386567 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 3 72 2717 9567 0.00110294117647058 0.000227510766880298 0.0032198465640147 0.992530345471522 0.990602328045735 0.994150998672766 0.04 0.0083261656660794 0.112476821760009 NA NA NA 0 0 0.0499440837058546 NA NA NA NA NA NA False True 0 1 1 0 0 1 0 0.146715126978284 0.0295671940549736 0.446850420922648 0 0 0.00135678188642832 0.992530345471522 0.990602328045735 0.994150998672766 99 Not assoc w R Not assoc w RI 5) Not assoc w R UP from NotAwRI to NotAwR yes 4 +Levofloxacin gyrA p.Thr836Ala gyrA_p.Thr836Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 142.964774304408 1 883 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0 0 0.00063124187675269 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Thr836Arg gyrA_p.Thr836Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 1 5 5842 21458 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.9997670409542 0.99945643574724 0.999924354643808 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.00943637980382 0.591567772689754 255 2040 False False 0.73461143444026 0.0155328045999449 6.56618384712436 0 0 0.00063124187675269 0.9997670409542 0.99945643574724 0.999924354643808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 1 4 2719 9635 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999585019192862 0.998937828281888 0.999886920491758 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.37091971678909 0.582315775027881 122 1102 False False 0 0 0 0 0 0 0 0.885895549834498 0.0179820541723419 8.95537117058933 0 0 0.0013557845626193 0.999585019192862 0.998937828281888 0.999886920491758 6 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Thr836Lys gyrA_p.Thr836Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Thr836Met gyrA_p.Thr836Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Tyr276His gyrA_p.Tyr276His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Tyr364Asp gyrA_p.Tyr364Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Tyr365His gyrA_p.Tyr365His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Tyr379Cys gyrA_p.Tyr379Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 5 2 5838 21461 0.000855724798904672 0.00027790803803495 0.00199583691247191 0.99990681638168 0.999663429698698 0.999988714832292 0.714285714285714 0.290420863737342 0.963307433823914 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5842895935533 1 883 2040 False False 9.19021925316889 1.50394433945951 96.541220823254 0 0 0.000631674245690789 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 1 2717 9638 0.00110294117647058 0.000227510766880298 0.0032198465640147 0.999896254798215 0.999422105789591 0.999997373402351 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 138.062537430878 1 457.5 1102 False False 0 0 0 0 0 0 0 10.6418844313581 0.853871105694195 556.864474256822 0 0 0.00135678188642832 0.999896254798215 0.999422105789591 0.999997373402351 4 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Tyr722Cys gyrA_p.Tyr722Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Val223Ile gyrA_p.Val223Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Val235Ala gyrA_p.Val235Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Val257Leu gyrA_p.Val257Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Val278Ile gyrA_p.Val278Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 6 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Val310Ile gyrA_p.Val310Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1428 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Val326Gly gyrA_p.Val326Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 1 2 5842 21461 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99990681638168 0.999663429698698 0.999988714832292 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 1.83678534748373 0.0311281139040964 35.2896458967866 0.514394017317937 195.5 2040 False False 1.83678534748373 0.0311281139040964 35.2896458967866 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Val326Leu gyrA_p.Val326Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Val327Leu gyrA_p.Val327Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Val352Ala gyrA_p.Val352Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Val352Leu gyrA_p.Val352Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1453 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Val352Met gyrA_p.Val352Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Val372Ala gyrA_p.Val372Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 4 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Val479Met gyrA_p.Val479Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 142.93371627475 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 137.896313968788 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Val516Ala gyrA_p.Val516Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1450 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Val517Leu gyrA_p.Val517Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1483 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Val51Ala gyrA_p.Val51Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1491 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Val544Leu gyrA_p.Val544Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Val596Met gyrA_p.Val596Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0941866911272879 Inf 0.213982274957884 105.5 2040 False False Inf 0.0941866911272879 Inf 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Val624Leu gyrA_p.Val624Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 3 2 5840 21461 0.000513434879342803 0.000105895133877182 0.00149973424244328 0.99990681638168 0.999663429698698 0.999988714832292 0.6 0.146632799634673 0.947255049473683 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5776024209454 1 883 2040 False False 5.51224315068493 0.63123591332421 66.0805594851213 0 0 0.000631457987209345 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 6 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Val649Met gyrA_p.Val649Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Val651Ala gyrA_p.Val651Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Val651Ile gyrA_p.Val651Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 8 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Val674Ile gyrA_p.Val674Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrA p.Val716Phe gyrA_p.Val716Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Val742Leu gyrA_p.Val742Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.56487735727821 0.58431003819195 215.5 2040 False False 0 0 5.56487735727821 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 2720 9635 0 0 0.00135528645033659 0.999585019192862 0.998937828281888 0.999886920491758 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.36894442066688 0.582297391718026 115.5 1102 False False 0 0 0 0 0 0 0 0 0 5.36894442066688 0 0 0.00135528645033659 0.999585019192862 0.998937828281888 0.999886920491758 42 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Val750Ala gyrA_p.Val750Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Val768Ala gyrA_p.Val768Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Val783Leu gyrA_p.Val783Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 7 5843 21456 0 0 0.000631133876986172 0.99967385733588 0.999328137654343 0.999868864001311 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1507 2040 False False 0 0 2.5485399472607 0 0 0.000631133876986172 0.99967385733588 0.999328137654343 0.999868864001311 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrA p.Val783Met gyrA_p.Val783Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.56487735727821 0.58431003819195 215.5 2040 False False 0 0 5.56487735727821 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance No change no 1 +Levofloxacin gyrB c.1008G>A gyrB_c.1008G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.-100C>T gyrB_c.-100C>T 1 upstream_gene_variant 5140 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1518 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 825 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 2 3) Uncertain significance No change no 1 +Levofloxacin gyrB c.1011A>G gyrB_c.1011A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1012C>T gyrB_c.1012C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1020C>T gyrB_c.1020C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1026C>T gyrB_c.1026C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.-102G>A gyrB_c.-102G>A 1 upstream_gene_variant 5138 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Levofloxacin gyrB c.1035C>G gyrB_c.1035C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.-104A>C gyrB_c.-104A>C 1 upstream_gene_variant 5136 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Levofloxacin gyrB c.1050C>A gyrB_c.1050C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1059C>T gyrB_c.1059C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1068T>G gyrB_c.1068T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.-106C>T gyrB_c.-106C>T 1 upstream_gene_variant 5134 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1531 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 833 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB c.-107A>C gyrB_c.-107A>C 1 upstream_gene_variant 5133 1 0 0 0 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1521 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Levofloxacin gyrB c.1080G>A gyrB_c.1080G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.56487735727821 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1080G>C gyrB_c.1080G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1098G>A gyrB_c.1098G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.-10T>C gyrB_c.-10T>C 1 upstream_gene_variant 5230 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Levofloxacin gyrB c.1107C>T gyrB_c.1107C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 13 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1113C>G gyrB_c.1113C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1119C>T gyrB_c.1119C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 16 5843 21447 0 0 0.000631133876986172 0.99925453105344 0.998789686679379 0.999573841954248 0 0 0.205907214207822 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.952125276634789 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 9 2720 9630 0 0 0.00135528645033659 0.99906629318394 0.998228276906464 0.999572963722204 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.79492921444566 NA NA NA NA NA NA 30 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.111C>T gyrB_c.111C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.89146792489366 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1131C>T gyrB_c.1131C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1140C>A gyrB_c.1140C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.89146792489366 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.57852451631077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1152G>C gyrB_c.1152G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1158G>A gyrB_c.1158G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1167C>T gyrB_c.1167C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 29 5841 21434 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.998648837534361 0.99806007718306 0.999094924371041 0.064516129032258 0.0079109834618547 0.214216157163402 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.253074284634775 0.0292554368471184 1.00091404109983 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 12 2719 9627 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.998755057578587 0.997826347023296 0.999356559855396 0.0769230769230769 0.00194562849734675 0.360297435267877 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.295053328429569 0.00690326052774264 1.99604224370996 NA NA NA NA NA NA 202 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1200C>G gyrB_c.1200C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 3 5842 21460 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99986022457252 0.999591571764338 0.999971174018896 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.22446650690402 0.0233203404016305 15.2512395040111 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1209G>A gyrB_c.1209G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1209G>T gyrB_c.1209G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 1 5841 21462 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99995340819084 0.99974043469953 0.999998820398217 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 7.3487416538264 0.382468755528661 432.333734199629 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.120C>G gyrB_c.120C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.120C>T gyrB_c.120C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.56487735727821 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1215C>A gyrB_c.1215C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1215C>T gyrB_c.1215C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 18.8709233025667 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1218T>A gyrB_c.1218T>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 18.8709233025667 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1224C>T gyrB_c.1224C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 5842 21461 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99990681638168 0.999663429698698 0.999988714832292 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.83678534748373 0.0311281139040964 35.2896458967866 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1242G>A gyrB_c.1242G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1248C>G gyrB_c.1248C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1275G>A gyrB_c.1275G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1296C>T gyrB_c.1296C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1302C>T gyrB_c.1302C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1305C>A gyrB_c.1305C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1311A>G gyrB_c.1311A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.89146792489366 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1312T>C gyrB_c.1312T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1320C>T gyrB_c.1320C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1324C>T gyrB_c.1324C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1335C>T gyrB_c.1335C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1338T>C gyrB_c.1338T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1341C>T gyrB_c.1341C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1356G>A gyrB_c.1356G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.138T>C gyrB_c.138T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.-13G>C gyrB_c.-13G>C 1 upstream_gene_variant 5227 0 0 0 0 2 0 5841 21463 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 1 0.999828143201531 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1567 2040 False False Inf 0.689929368506768 Inf 0 0 0.000631349913487419 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Levofloxacin gyrB c.1425C>T gyrB_c.1425C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1431G>A gyrB_c.1431G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1441C>T gyrB_c.1441C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 6 5843 21457 0 0 0.000631133876986172 0.99972044914504 0.999391635540124 0.999897403075094 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.1200699364824 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.57852451631077 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1446C>T gyrB_c.1446C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.144G>A gyrB_c.144G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 7 0 5836 21463 0.00119801471846654 0.000481795418920789 0.00246680058103687 1 0.999828143201531 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 5.29853607329083 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 7 0 2713 9639 0.0025735294117647 0.0010352988504908 0.00529522151968195 1 0.999617369678334 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 5.11563245903239 Inf NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1458C>T gyrB_c.1458C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1476C>G gyrB_c.1476C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1482C>T gyrB_c.1482C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 12 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1485G>T gyrB_c.1485G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1488G>A gyrB_c.1488G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 18.8709233025667 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1489C>T gyrB_c.1489C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1497C>T gyrB_c.1497C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 13 5843 21450 0 0 0.000631133876986172 0.99939430648092 0.998964468353895 0.999677455549724 0 0 0.24705263800047 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.20497274784395 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.57852451631077 NA NA NA NA NA NA 13 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.-14A>G gyrB_c.-14A>G 1 upstream_gene_variant 5226 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB c.1506T>C gyrB_c.1506T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1506T>G gyrB_c.1506T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.150C>A gyrB_c.150C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1512G>T gyrB_c.1512G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1524G>C gyrB_c.1524G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1527G>A gyrB_c.1527G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1533C>G gyrB_c.1533C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1536G>A gyrB_c.1536G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1536G>C gyrB_c.1536G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.153C>T gyrB_c.153C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1554T>C gyrB_c.1554T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1563G>A gyrB_c.1563G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1566G>C gyrB_c.1566G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1566G>T gyrB_c.1566G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1569C>G gyrB_c.1569C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 5842 21461 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99990681638168 0.999663429698698 0.999988714832292 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.83678534748373 0.0311281139040964 35.2896458967866 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1569C>T gyrB_c.1569C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1575C>T gyrB_c.1575C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1578G>A gyrB_c.1578G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 17 65 5826 21398 0.00290946431627588 0.00169575541737898 0.00465426040746216 0.996971532404603 0.996141575099664 0.997661938617565 0.207317073170731 0.125657951298265 0.31105170394255 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.960590456573978 0.527438419508627 1.6598112335714 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 15 43 2705 9596 0.00551470588235294 0.00308972573905283 0.00907938157352261 0.99553895632327 0.993995656827409 0.996769695588256 0.258620689655172 0.152551868365104 0.390431660868475 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 0 1.23750161200189 0.637550643048934 2.27640035617602 NA NA NA NA NA NA 82 5) Not assoc w R Now listed Silent mutation no 0 +Levofloxacin gyrB c.1584G>A gyrB_c.1584G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1585C>T gyrB_c.1585C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1593C>T gyrB_c.1593C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1602T>C gyrB_c.1602T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1611C>A gyrB_c.1611C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1617T>C gyrB_c.1617T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.67374186922286 0.0467931454016956 287.712465214691 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1620T>C gyrB_c.1620T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 10 5843 21453 0 0 0.000631133876986172 0.9995340819084 0.999143327515781 0.999776552276323 0 0 0.30849710781876 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.63855069807244 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 16 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1623C>G gyrB_c.1623C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1632G>A gyrB_c.1632G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1638G>A gyrB_c.1638G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1639T>C gyrB_c.1639T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 0 NA NA NA 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.67374186922286 0.0467931454016956 287.712465214691 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1642T>C gyrB_c.1642T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1668C>A gyrB_c.1668C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.89146792489366 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 18.8709233025667 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1674C>T gyrB_c.1674C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1680T>C gyrB_c.1680T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 8 5842 21455 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99962726552672 0.99926569731444 0.999839066414514 0.111111111111111 0.00280913674659921 0.482496514917337 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.45906795617939 0.0103475211102756 3.425357676166 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 6 2719 9633 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999377528789293 0.998645638320949 0.999771530871485 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.590474439132033 0.0128360606385712 4.87020043259644 NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1683G>A gyrB_c.1683G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1683G>C gyrB_c.1683G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1687T>C gyrB_c.1687T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1692A>G gyrB_c.1692A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1698G>A gyrB_c.1698G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1707C>T gyrB_c.1707C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.89146792489366 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 18.8709233025667 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1713C>G gyrB_c.1713C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1725C>G gyrB_c.1725C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1725C>T gyrB_c.1725C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1734G>A gyrB_c.1734G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 9 5843 21454 0 0 0.000631133876986172 0.99958067371756 0.999204138016772 0.999808239967157 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.86084922251217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 8 2720 9631 0 0 0.00135528645033659 0.999170038385724 0.99836530325407 0.99964161554927 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.07582396316403 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1740C>T gyrB_c.1740C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1773G>C gyrB_c.1773G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1803C>T gyrB_c.1803C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1812A>G gyrB_c.1812A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1815C>T gyrB_c.1815C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1818C>T gyrB_c.1818C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1821T>C gyrB_c.1821T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1854T>C gyrB_c.1854T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1861T>C gyrB_c.1861T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1887G>C gyrB_c.1887G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1912C>T gyrB_c.1912C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1914G>C gyrB_c.1914G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 5842 21461 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99990681638168 0.999663429698698 0.999988714832292 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.83678534748373 0.0311281139040964 35.2896458967866 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1917C>T gyrB_c.1917C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.89146792489366 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1920C>T gyrB_c.1920C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1923C>T gyrB_c.1923C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.89146792489366 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1947C>G gyrB_c.1947C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1947C>T gyrB_c.1947C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1953G>A gyrB_c.1953G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1959C>A gyrB_c.1959C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1959C>T gyrB_c.1959C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1977G>C gyrB_c.1977G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1980C>T gyrB_c.1980C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1983C>T gyrB_c.1983C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 14 510 5829 20953 0.00239602943693308 0.0013105314105045 0.00401686566193227 0.976238177328425 0.97411160424599 0.9782343805249 0.0267175572519083 0.0146820334083909 0.0444215226785997 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.0986756548562125 0.0535265668612244 0.167255035466204 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 5 199 2715 9440 0.00183823529411764 0.000597130943349739 0.00428457163587036 0.979354704844901 0.976315011267679 0.982099663718043 0.0245098039215686 0.008005098786001 0.0562678598233771 NA NA NA NA NA NA NA NA NA NA NA NA False True 1 1 1 0 0 0 0 0.0873613000546008 0.0280228339678419 0.207643789332947 NA NA NA NA NA NA 203 5) Not assoc w R Now listed Silent mutation no 0 +Levofloxacin gyrB c.198C>T gyrB_c.198C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.1995C>T gyrB_c.1995C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.-19T>C gyrB_c.-19T>C 1 upstream_gene_variant 5221 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB c.-1C>G gyrB_c.-1C>G 1 upstream_gene_variant 5239 1 9 0 9 0 9 5843 21454 0 0 0.000631133876986172 0.99958067371756 0.999204138016772 0.999808239967157 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.336267116879942 0 0 1.86084922251217 0.219686387671972 137 2040 False False 0 0 1.86084922251217 0 0 0.000631133876986172 0.99958067371756 0.999204138016772 0.999808239967157 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 2720 9633 0 0 0.00135528645033659 0.999377528789293 0.998645638320949 0.999771530871485 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.00974784500922 0.35000722127353 94 1102 False False 0 0 0 0 0 0 0 0 0 3.00974784500922 0 0 0.00135528645033659 0.999377528789293 0.998645638320949 0.999771530871485 1 3) Uncertain significance No change no 1 +Levofloxacin gyrB c.-1C>T gyrB_c.-1C>T 1 upstream_gene_variant 5239 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1522 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 829 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB c.2001C>G gyrB_c.2001C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.2007T>C gyrB_c.2007T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.2017C>T gyrB_c.2017C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.2019G>C gyrB_c.2019G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.2027A>G gyrB_c.2027A>G 1 stop_retained_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.205C>T gyrB_c.205C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 5840 21463 0.000513434879342803 0.000105895133877182 0.00149973424244328 1 0.999828143201531 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.51820267072123 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.207G>A gyrB_c.207G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.213G>A gyrB_c.213G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.219C>A gyrB_c.219C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.231C>T gyrB_c.231C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 7 1 5836 21462 0.00119801471846654 0.000481795418920789 0.00246680058103687 0.99995340819084 0.99974043469953 0.999998820398217 0.875 0.473490329124793 0.996840276468748 NA NA NA NA NA NA NA NA NA NA NA NA False False 25.7426319396847 3.30576787112106 1153.1231270102 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.-26C>G gyrB_c.-26C>G 1 upstream_gene_variant 5214 1 3 0 3 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89146792489366 1 319.5 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.57852451631077 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 8.57852451631077 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 1 3) Uncertain significance No change no 1 +Levofloxacin gyrB c.270C>T gyrB_c.270C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.273C>G gyrB_c.273C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.285C>A gyrB_c.285C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 4 5842 21459 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99981363276336 0.999522895233871 0.999949218940757 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.918307086614173 0.0186435710006194 9.27999188457764 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 3 2719 9636 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999688764394646 0.999090709558603 0.999935811136198 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.18131666053696 0.0224941657498392 14.7172429763561 NA NA NA NA NA NA 18 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.285C>G gyrB_c.285C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.288C>T gyrB_c.288C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.-28C>T gyrB_c.-28C>T 1 upstream_gene_variant 5212 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB c.291C>T gyrB_c.291C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 10 5843 21453 0 0 0.000631133876986172 0.9995340819084 0.999143327515781 0.999776552276323 0 0 0.30849710781876 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.63855069807244 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 7 2720 9632 0 0 0.00135528645033659 0.999273783587509 0.99850429270085 0.999707975074577 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.45859411933764 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.294G>T gyrB_c.294G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.307C>T gyrB_c.307C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.89146792489366 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.309A>G gyrB_c.309A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.30C>T gyrB_c.30C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.315C>G gyrB_c.315C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.339G>C gyrB_c.339G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.339G>T gyrB_c.339G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.351T>G gyrB_c.351T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 18.8709233025667 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.358C>T gyrB_c.358C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.-35G>T gyrB_c.-35G>T 1 upstream_gene_variant 5205 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1536 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB c.366C>T gyrB_c.366C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.89146792489366 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.372C>T gyrB_c.372C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.-37C>T gyrB_c.-37C>T 1 upstream_gene_variant 5203 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB c.-39A>G gyrB_c.-39A>G 1 upstream_gene_variant 5201 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB c.39C>T gyrB_c.39C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.402G>A gyrB_c.402G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.435G>A gyrB_c.435G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.441T>G gyrB_c.441T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.-45C>G gyrB_c.-45C>G 1 upstream_gene_variant 5195 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance No change no 1 +Levofloxacin gyrB c.462A>G gyrB_c.462A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.468G>T gyrB_c.468G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.471C>T gyrB_c.471C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.474C>G gyrB_c.474C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.89146792489366 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.480A>G gyrB_c.480A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.67374186922286 0.0467931454016956 287.712465214691 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.492C>T gyrB_c.492C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 4 5842 21459 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99981363276336 0.999522895233871 0.999949218940757 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.918307086614173 0.0186435710006194 9.27999188457764 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 2720 9635 0 0 0.00135528645033659 0.999585019192862 0.998937828281888 0.999886920491758 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 5.36894442066688 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.495G>A gyrB_c.495G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.67374186922286 0.0467931454016956 287.712465214691 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.-4G>A gyrB_c.-4G>A 1 upstream_gene_variant 5236 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Levofloxacin gyrB c.513G>A gyrB_c.513G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 30 5841 21433 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.998602245725201 0.998005215186117 0.999056748531327 0.0625 0.00766073634645639 0.208069429895007 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.244627061576214 0.0283207052333433 0.964579144560761 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 12 2719 9627 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.998755057578587 0.997826347023296 0.999356559855396 0.0769230769230769 0.00194562849734675 0.360297435267877 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.295053328429569 0.00690326052774264 1.99604224370996 NA NA NA NA NA NA 208 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.51C>T gyrB_c.51C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.67374186922286 0.0467931454016956 287.712465214691 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.525C>G gyrB_c.525C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.56487735727821 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.528C>T gyrB_c.528C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.-52C>T gyrB_c.-52C>T 1 upstream_gene_variant 5188 1 3 0 3 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89146792489366 1 319.5 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB c.531C>G gyrB_c.531C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.531C>T gyrB_c.531C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.56487735727821 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 17 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.534T>G gyrB_c.534T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.-53C>G gyrB_c.-53C>G 1 upstream_gene_variant 5187 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB c.546C>G gyrB_c.546C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 5842 21461 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99990681638168 0.999663429698698 0.999988714832292 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.83678534748373 0.0311281139040964 35.2896458967866 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.549G>A gyrB_c.549G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.54C>T gyrB_c.54C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.-54C>T gyrB_c.-54C>T 1 upstream_gene_variant 5186 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 1 3) Uncertain significance No change no 1 +Levofloxacin gyrB c.-55C>T gyrB_c.-55C>T 1 upstream_gene_variant 5185 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB c.-55delC gyrB_c.-55delC 1 upstream_gene_variant 5184 1 7 0 7 0 7 5843 21456 0 0 0.000631133876986172 0.99967385733588 0.999328137654343 0.999868864001311 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 2.5485399472607 0.358203244449244 169.5 2040 False False 0 0 2.5485399472607 0 0 0.000631133876986172 0.99967385733588 0.999328137654343 0.999868864001311 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 2720 9633 0 0 0.00135528645033659 0.999377528789293 0.998645638320949 0.999771530871485 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.00974784500922 0.35000722127353 94 1102 False False 0 0 0 0 0 0 0 0 0 3.00974784500922 0 0 0.00135528645033659 0.999377528789293 0.998645638320949 0.999771530871485 9 3) Uncertain significance No change no 1 +Levofloxacin gyrB c.561C>T gyrB_c.561C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.57T>C gyrB_c.57T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.580C>T gyrB_c.580C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.582G>C gyrB_c.582G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.-58C>G gyrB_c.-58C>G 1 upstream_gene_variant 5182 1 2 0 2 1 3 5842 21460 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99986022457252 0.999591571764338 0.999971174018896 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 19.5700107416863 1 883 2040 False False 1.22446650690402 0.0233203404016305 15.2512395040111 0 0 0.00063124187675269 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB c.-5G>A gyrB_c.-5G>A 1 upstream_gene_variant 5235 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB c.-60_-59insG gyrB_c.-60_-59insG 1 upstream_gene_variant 5180 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1550 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 842 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 4 3) Uncertain significance No change no 1 +Levofloxacin gyrB c.-60_-59insGC gyrB_c.-60_-59insGC 1 upstream_gene_variant 5180 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1576 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 859 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB c.600C>G gyrB_c.600C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.603C>T gyrB_c.603C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.89146792489366 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 18.8709233025667 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.609G>A gyrB_c.609G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.60C>A gyrB_c.60C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.60C>T gyrB_c.60C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.-60T>C gyrB_c.-60T>C 1 upstream_gene_variant 5180 1 1 0 1 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 142.93371627475 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 831 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 2 3) Uncertain significance No change no 1 +Levofloxacin gyrB c.-60T>G gyrB_c.-60T>G 1 upstream_gene_variant 5180 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1581 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB c.624G>T gyrB_c.624G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.56487735727821 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.651G>A gyrB_c.651G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.669C>G gyrB_c.669C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.66G>C gyrB_c.66G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.-66G>T gyrB_c.-66G>T 1 upstream_gene_variant 5174 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB c.678C>T gyrB_c.678C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 4 5842 21459 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99981363276336 0.999522895233871 0.999949218940757 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.918307086614173 0.0186435710006194 9.27999188457764 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.67C>T gyrB_c.67C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.693G>A gyrB_c.693G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.-6C>T gyrB_c.-6C>T 1 upstream_gene_variant 5234 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB c.708C>G gyrB_c.708C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.720C>G gyrB_c.720C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.726A>G gyrB_c.726A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 9 5 5834 21458 0.00154030463802841 0.000704559638966774 0.00292195530235611 0.9997670409542 0.99945643574724 0.999924354643808 0.642857142857142 0.351380110615991 0.87240157014084 NA NA NA NA NA NA NA NA NA NA NA NA False False 6.62056907781967 1.99146706418478 25.1548308293539 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 2717 9639 0.00110294117647058 0.000227510766880298 0.0032198465640147 1 0.999617369678334 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.46497956541773 Inf NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.72G>A gyrB_c.72G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.747C>A gyrB_c.747C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.750C>T gyrB_c.750C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.75C>T gyrB_c.75C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.771G>C gyrB_c.771G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.780C>T gyrB_c.780C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.789C>T gyrB_c.789C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 7 5843 21456 0 0 0.000631133876986172 0.99967385733588 0.999328137654343 0.999868864001311 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.5485399472607 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 18.8709233025667 NA NA NA NA NA NA 14 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.78C>A gyrB_c.78C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.798C>G gyrB_c.798C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 5843 21458 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.0087500478358 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 2720 9635 0 0 0.00135528645033659 0.999585019192862 0.998937828281888 0.999886920491758 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 5.36894442066688 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.801C>A gyrB_c.801C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.807C>T gyrB_c.807C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.-80C>A gyrB_c.-80C>A 1 upstream_gene_variant 5160 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB c.822C>T gyrB_c.822C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 5843 21458 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.0087500478358 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 5 2720 9634 0 0 0.00135528645033659 0.999481273991078 0.998789885214303 0.999831550309162 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.8675231049739 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.-83C>T gyrB_c.-83C>T 1 upstream_gene_variant 5157 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance No change no 1 +Levofloxacin gyrB c.843G>A gyrB_c.843G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.-84G>A gyrB_c.-84G>A 1 upstream_gene_variant 5156 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB c.852G>A gyrB_c.852G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.861G>A gyrB_c.861G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.867C>T gyrB_c.867C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.870G>A gyrB_c.870G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 16 5843 21447 0 0 0.000631133876986172 0.99925453105344 0.998789686679379 0.999573841954248 0 0 0.205907214207822 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.952125276634789 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 6 2720 9633 0 0 0.00135528645033659 0.999377528789293 0.998645638320949 0.999771530871485 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.00974784500922 NA NA NA NA NA NA 47 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.-87C>G gyrB_c.-87C>G 1 upstream_gene_variant 5153 1 2 0 2 1 4 5842 21459 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99981363276336 0.999522895233871 0.999949218940757 0.2 0.00505076337946806 0.716417936118089 0 0 0.841886116991581 0 0 0.602364635616474 0 0 19.5691016337055 1 883 2040 False False 0.918307086614173 0.0186435710006194 9.27999188457764 0 0 0.00063124187675269 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB c.885C>T gyrB_c.885C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 42 427 5801 21036 0.00718808831079924 0.00518531039519677 0.00970391458252417 0.980105297488701 0.97814750664387 0.981931484102725 0.0895522388059701 0.0653035687890198 0.119120360889897 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.356682426150381 0.253019860939017 0.491139644671299 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 7 98 2713 9541 0.0025735294117647 0.0010352988504908 0.00529522151968195 0.989832970225127 0.987623444956283 0.991738423009784 0.0666666666666666 0.0272215964420653 0.132543271582352 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 0 0.251197935864356 0.0982983232022831 0.538269579605942 NA NA NA NA NA NA 650 5) Not assoc w R Now listed Silent mutation no 0 +Levofloxacin gyrB c.897G>A gyrB_c.897G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.-89C>A gyrB_c.-89C>A 1 upstream_gene_variant 5151 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB c.903G>C gyrB_c.903G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.89146792489366 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 18.8709233025667 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.915C>G gyrB_c.915C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.915C>T gyrB_c.915C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.89146792489366 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.921C>T gyrB_c.921C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.927C>T gyrB_c.927C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 6 5843 21457 0 0 0.000631133876986172 0.99972044914504 0.999391635540124 0.999897403075094 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.1200699364824 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 6 2720 9633 0 0 0.00135528645033659 0.999377528789293 0.998645638320949 0.999771530871485 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.00974784500922 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.93C>A gyrB_c.93C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.93C>T gyrB_c.93C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 15 8 5828 21455 0.00256717439671401 0.00143751780890291 0.00423063446053587 0.99962726552672 0.99926569731444 0.999839066414514 0.652173913043478 0.427343963036494 0.83623640162505 NA NA NA NA NA NA NA NA NA NA NA NA False False 6.90256091283459 2.74553491082687 18.8015936905506 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 5 4 2715 9635 0.00183823529411764 0.000597130943349739 0.00428457163587036 0.999585019192862 0.998937828281888 0.999886920491758 0.555555555555555 0.212008506778868 0.863004337734833 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.43600368324125 0.953932677572901 22.3656173042633 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.-93T>C gyrB_c.-93T>C 1 upstream_gene_variant 5147 1 2 0 2 1 5 5842 21458 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.9997670409542 0.99945643574724 0.999924354643808 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.841886116991581 0 0 0.521823750104981 0 0 19.5681925261453 1 883 2040 False False 0.73461143444026 0.0155328045999449 6.56618384712436 0 0 0.00063124187675269 0.9997670409542 0.99945643574724 0.999924354643808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Levofloxacin gyrB c.942C>A gyrB_c.942C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.945C>T gyrB_c.945C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 18.8709233025667 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.-95G>C gyrB_c.-95G>C 1 upstream_gene_variant 5145 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB c.963C>T gyrB_c.963C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.969G>A gyrB_c.969G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 3 5841 21460 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99986022457252 0.999591571764338 0.999971174018896 0.4 0.0527449505263169 0.853367200365326 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.44935227986075 0.204519727205419 21.3860749684357 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.975G>A gyrB_c.975G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.984G>C gyrB_c.984G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.984G>T gyrB_c.984G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.-98G>T gyrB_c.-98G>T 1 upstream_gene_variant 5142 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1537 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB c.999G>A gyrB_c.999G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin gyrB c.-9A>G gyrB_c.-9A>G 1 upstream_gene_variant 5231 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB LoF gyrB_LoF 1 LoF (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Ala115Val gyrB_p.Ala115Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ala130Ser gyrB_p.Ala130Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 16 0 16 0 17 5843 21446 0 0 0.000631133876986172 0.99920793924428 0.99873213590018 0.999538529867378 0 0 0.195064322969093 0 0 0.205907214207822 0 0 0.195064322969093 0 0 0.952080877425358 0.0318612714298972 50 2040 False False 0 0 0.889778498175186 0 0 0.000631133876986172 0.99920793924428 0.99873213590018 0.999538529867378 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 18 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ala162Glu gyrB_p.Ala162Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ala162Ser gyrB_p.Ala162Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 5843 21457 0 0 0.000631133876986172 0.99972044914504 0.999391635540124 0.999897403075094 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.1200699364824 0.35257212959262 148.5 2040 False False 0 0 3.1200699364824 0 0 0.000631133876986172 0.99972044914504 0.999391635540124 0.999897403075094 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 2720 9635 0 0 0.00135528645033659 0.999585019192862 0.998937828281888 0.999886920491758 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.36894442066688 0.582297391718026 115.5 1102 False False 0 0 0 0 0 0 0 0 0 5.36894442066688 0 0 0.00135528645033659 0.999585019192862 0.998937828281888 0.999886920491758 7 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ala175Thr gyrB_p.Ala175Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 4 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ala191Asp gyrB_p.Ala191Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Ala229Thr gyrB_p.Ala229Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Ala233Gly gyrB_p.Ala233Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1554 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ala233Pro gyrB_p.Ala233Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 5 0 5838 21463 0.000855724798904672 0.00027790803803495 0.00199583691247191 1 0.999828143201531 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 1568 2040 False False Inf 3.36756214650866 Inf 0 0 0.000631674245690789 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ala233Val gyrB_p.Ala233Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Ala237Gly gyrB_p.Ala237Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ala238Gly gyrB_p.Ala238Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1527 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ala238Thr gyrB_p.Ala238Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ala242Pro gyrB_p.Ala242Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1513 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 823 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Ala242Thr gyrB_p.Ala242Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ala2Ser gyrB_p.Ala2Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 5841 21463 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 1 0.999828143201531 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1538 2040 False False Inf 0.689929368506768 Inf 0 0 0.000631349913487419 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 835 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Ala332Val gyrB_p.Ala332Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ala355Thr gyrB_p.Ala355Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 2 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ala398Val gyrB_p.Ala398Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 1 7 1 8 5842 21455 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99962726552672 0.99926569731444 0.999839066414514 0.111111111111111 0.00280913674659921 0.482496514917337 0.125 0.0031597235312519 0.526509670875206 0.111111111111111 0.00280913674659921 0.482496514917337 0.524649092776446 0.0116425982614324 4.08515941780776 1 883 2040 False False 0.45906795617939 0.0103475211102756 3.425357676166 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99962726552672 0.99926569731444 0.999839066414514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 1 3 1 4 2719 9635 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999585019192862 0.998937828281888 0.999886920491758 0.2 0.00505076337946806 0.716417936118089 0.25 0.00630946320970987 0.805879550316756 0.2 0.00505076337946806 0.716417936118089 1.18119406644599 0.0224918313494791 14.7157158511236 1 147 1102 False False 0 0 0 0 0 0 0 0.885895549834498 0.0179820541723419 8.95537117058933 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999585019192862 0.998937828281888 0.999886920491758 6 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ala403Ser gyrB_p.Ala403Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 83 5841 21380 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.996132879839724 0.995208345504486 0.99691871870911 0.0235294117647058 0.00286233192164864 0.0824237444495757 NA NA NA 0 0 0.0434711521664418 NA NA NA NA NA NA False True 0.0882007743351423 0.010501843465602 0.328996303052019 0 0 0.000631349913487419 0.996132879839724 0.995208345504486 0.99691871870911 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 1 41 2719 9598 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.995746446726838 0.994233953422894 0.996945899426634 0.0238095238095238 0.000602623301603574 0.125658557174992 NA NA NA 0 0 0.0860438362940284 NA NA NA NA NA NA False True 0 1 1 0 0 1 0 0.086096933054656 0.00213173748413386 0.507869500516272 0 0 0.0013557845626193 0.995746446726838 0.994233953422894 0.996945899426634 375 Not assoc w R 5) Not assoc w R No change yes 1 +Levofloxacin gyrB p.Ala403Val gyrB_p.Ala403Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ala423Val gyrB_p.Ala423Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89146792489366 1 319.5 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 22 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ala432Val gyrB_p.Ala432Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ala467Thr gyrB_p.Ala467Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1520 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0 0 0.00063124187675269 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 827 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 1 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ala467Val gyrB_p.Ala467Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1514 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ala504Thr gyrB_p.Ala504Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 1 4 13 5 5830 21458 0.00222488447715214 0.00118517251163732 0.00380161509892997 0.9997670409542 0.99945643574724 0.999924354643808 0.722222222222222 0.465198034416943 0.90305078747444 0.2 0.00505076337946806 0.716417936118089 0.166666666666666 0.00421074451448947 0.641234578997674 0.920154373927958 0.0186810686193871 9.29864585784967 1 319.5 2040 False False 9.56960548885077 3.19961358883504 34.3031151605841 0.00017149717029669 4.3419230012457e-06 0.000955146583926311 0.9997670409542 0.99945643574724 0.999924354643808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 1 3 8 3 2712 9636 0.00294117647058823 0.00127061997302132 0.00578702225151795 0.999688764394646 0.999090709558603 0.999935811136198 0.727272727272727 0.390257440427578 0.939782265827093 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 1.18436578171091 0.0225522050697131 14.755241898487 1 457.5 1102 False False 0 0 0 0 0 0 0 9.47492625368731 2.27174142452265 55.4765126259458 0.000368595650571323 9.33199036171622e-06 0.00205195403726318 0.999688764394646 0.999090709558603 0.999935811136198 3 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ala504Val gyrB_p.Ala504Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 16 6 10 32 10 5811 21453 0.0054766387129899 0.00374894343107096 0.00772265885726919 0.9995340819084 0.999143327515781 0.999776552276323 0.761904761904761 0.605497570978424 0.87948381350782 0.375 0.151983675081122 0.645653905697921 0.375 0.151983675081122 0.645653905697921 2.21507485802787 0.66133371629449 6.72986351907827 0.126812248209577 78 2040 False False 11.8137325761486 5.66064159122219 26.9447927989127 0.00103145951521402 0.000378618542096117 0.00224369106586376 0.9995340819084 0.999143327515781 0.999776552276323 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 12 6 6 22 6 2698 9633 0.00808823529411764 0.00507559482038076 0.0122202167587801 0.999377528789293 0.998645638320949 0.999771530871485 0.785714285714285 0.590468973494171 0.917039387612361 0.5 0.210944638239296 0.789055361760703 0.5 0.210944638239296 0.789055361760703 3.57042253521126 0.953551116627561 13.3670756324679 0.0297792025394837 31 1102 False False 0 0 0 0 0 0 0 13.0915492957746 5.13940123319019 39.5215339901177 0.0022189349112426 0.000814731716918805 0.00482338489787813 0.999377528789293 0.998645638320949 0.999771530871485 19 Assoc w R Assoc w RI Previous WHO guidance 2) Assoc w R - Interim No change yes Prev. WHO 1 +Levofloxacin gyrB p.Ala508Val gyrB_p.Ala508Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ala564Thr gyrB_p.Ala564Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ala593Val gyrB_p.Ala593Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89146792489366 1 319.5 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.57852451631077 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 8.57852451631077 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 206 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ala597Thr gyrB_p.Ala597Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 142.964774304408 1 883 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0 0 0.00063124187675269 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ala618Asp gyrB_p.Ala618Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Ala618Thr gyrB_p.Ala618Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 1 5840 21462 0.000513434879342803 0.000105895133877182 0.00149973424244328 0.99995340819084 0.99974043469953 0.999998820398217 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 143.013625436925 1 883 2040 False False 11.025 0.884946155157416 576.804300084131 0 0 0.000631457987209345 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 137.961202437293 1 457.5 1102 False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 0 0 0.0013557845626193 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ala618Val gyrB_p.Ala618Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1580 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 862 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Ala641Asp gyrB_p.Ala641Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1566 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0 0 0.00063124187675269 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 854 1102 False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 0 0 0.0013557845626193 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Ala643Asp gyrB_p.Ala643Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1582 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ala644Asp gyrB_p.Ala644Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 1 4 5842 21459 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99981363276336 0.999522895233871 0.999949218940757 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.56583008746417 0.58432028936451 238 2040 False False 0.918307086614173 0.0186435710006194 9.27999188457764 0 0 0.00063124187675269 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 2719 9637 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999792509596431 0.999250676427901 0.999974870961701 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8778635755656 1 457.5 1102 False False 0 0 0 0 0 0 0 1.77215888194189 0.0300270423699391 34.0580978516331 0 0 0.0013557845626193 0.999792509596431 0.999250676427901 0.999974870961701 4 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ala644del gyrB_p.Ala644del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 18 0 18 2 20 5841 21443 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.999068163816801 0.998561219655491 0.999430720271997 0.0909090909090909 0.0112055860241509 0.291612741553933 0 0 0.185301968137852 0 0 0.168433470983085 0 0 0.835316535256511 0.0199016831392792 42 2040 False False 0.367111795925355 0.0415943473659495 1.5120327780201 0 0 0.000631349913487419 0.999068163816801 0.998561219655491 0.999430720271997 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 0 11 0 12 2720 9627 0 0 0.00135528645033659 0.998755057578587 0.997826347023296 0.999356559855396 0 0 0.264648469397051 0 0 0.284914152918154 0 0 0.264648469397051 0 0 1.41128579153047 0.1371413244508 53 1102 False False 0 0 0 0 0 0 0 0 0 1.2747953585009 0 0 0.00135528645033659 0.998755057578587 0.997826347023296 0.999356559855396 44 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Ala78Gly gyrB_p.Ala78Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ala78Thr gyrB_p.Ala78Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ala78Val gyrB_p.Ala78Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ala87Gly gyrB_p.Ala87Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ala90Gly gyrB_p.Ala90Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 7 5843 21456 0 0 0.000631133876986172 0.99967385733588 0.999328137654343 0.999868864001311 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 2.5485399472607 0.358203244449244 169.5 2040 False False 0 0 2.5485399472607 0 0 0.000631133876986172 0.99967385733588 0.999328137654343 0.999868864001311 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 2 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ala90Thr gyrB_p.Ala90Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Arg192Pro gyrB_p.Arg192Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Arg212Thr gyrB_p.Arg212Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1508 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Arg417Cys gyrB_p.Arg417Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0941866911272879 Inf 0.213982274957884 105.5 2040 False False Inf 0.0941866911272879 Inf 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0908652957857324 Inf 0.220082530949106 80 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Arg429Cys gyrB_p.Arg429Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1541 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 837 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Arg446Cys gyrB_p.Arg446Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 32 10 22 17 22 5826 21441 0.00290946431627588 0.00169575541737898 0.00465426040746216 0.998974980198481 0.998448516553724 0.999357517570523 0.435897435897435 0.278107629676409 0.603791982985728 0.3125 0.1611847240882 0.500077581632169 0.3125 0.1611847240882 0.500077581632169 1.67283025933901 0.706751233952697 3.68367926635713 0.193628633315905 87 2040 False False 2.84381144087632 1.41675276601211 5.61136533105236 0.00171350239890335 0.000821987205155259 0.00314892689362939 0.998974980198481 0.998448516553724 0.999357517570523 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 17 7 10 12 10 2708 9629 0.00441176470588235 0.00228163789982352 0.00769377081358202 0.998962547982155 0.998092919138308 0.999502392880449 0.545454545454545 0.322104754553171 0.756138134076983 0.411764705882352 0.184436961783946 0.670752846053242 0.411764705882352 0.184436961783946 0.670752846053242 2.48903249630723 0.803249413819124 7.25126874720185 0.0740535336909528 40 1102 False False 0 0 0 0 0 0 0 4.2669128508124 1.68723397892254 11.0335089055803 0.00257826887661141 0.00103720659849148 0.00530495996883536 0.998962547982155 0.998092919138308 0.999502392880449 4 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Arg446Gly gyrB_p.Arg446Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1515 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Arg446His gyrB_p.Arg446His 1 missense_variant (see "Genomic_coordinates" sheet) 1 13 3 10 3 10 5840 21453 0.000513434879342803 0.000105895133877182 0.00149973424244328 0.9995340819084 0.999143327515781 0.999776552276323 0.23076923076923 0.0503810734911515 0.53813153923404 0.23076923076923 0.0503810734911515 0.53813153923404 0.23076923076923 0.0503810734911515 0.53813153923404 1.10203767123287 0.194826487732604 4.28214028428906 0.747268554242915 282 2040 False False 1.10203767123287 0.194826487732604 4.28214028428906 0.000513434879342803 0.000105895133877182 0.00149973424244328 0.9995340819084 0.999143327515781 0.999776552276323 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 1 3 1 3 2719 9636 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999688764394646 0.999090709558603 0.999935811136198 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 1.18131666053696 0.0224941657498392 14.7172429763561 1 457.5 1102 False False 0 0 0 0 0 0 0 1.18131666053696 0.0224941657498392 14.7172429763561 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999688764394646 0.999090709558603 0.999935811136198 7 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Arg446Leu gyrB_p.Arg446Leu 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 0 1 2 2 5841 21461 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99990681638168 0.999663429698698 0.999988714832292 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 142.982548456817 1 883 2040 False False 3.67419962335216 0.266252080252227 50.6812073544246 0 0 0.000631349913487419 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Arg451His gyrB_p.Arg451His 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1575 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Arg523Cys gyrB_p.Arg523Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Arg523His gyrB_p.Arg523His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1562 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 852 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Arg523Ser gyrB_p.Arg523Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Arg553Gly gyrB_p.Arg553Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0941866911272879 Inf 0.213982274957884 105.5 2040 False False Inf 0.0941866911272879 Inf 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Arg553Trp gyrB_p.Arg553Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Arg575His gyrB_p.Arg575His 1 missense_variant (see "Genomic_coordinates" sheet) 1 28 1 27 4 29 5839 21434 0.000684579839123737 0.000186555462570677 0.00175186028923716 0.998648837534361 0.99806007718306 0.999094924371041 0.121212121212121 0.0340328814229786 0.28201622853722 0.0357142857142857 0.000903798755658059 0.183477597544623 0.0333333333333333 0.000843570926630479 0.172169455633412 0.135956816552809 0.00332393484080114 0.825255288360099 0.0188347020228021 41 2040 False False 0.506321937507012 0.129277397259391 1.44272579187675 0.000171232876712328 4.33523169605623e-06 0.00095367518755974 0.998648837534361 0.99806007718306 0.999094924371041 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 137.961202437293 1 457.5 1102 False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 0 0 0.0013557845626193 0.999896254798215 0.999422105789591 0.999997373402351 21 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Arg587Gly gyrB_p.Arg587Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1577 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Arg634Leu gyrB_p.Arg634Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Arg665Cys gyrB_p.Arg665Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Asn207Asp gyrB_p.Asn207Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Asn399Ser gyrB_p.Asn399Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Asn499Asp gyrB_p.Asn499Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 18 14 4 19 7 5824 21456 0.00325175423583775 0.00195886894634834 0.00507337943019098 0.99967385733588 0.999328137654343 0.999868864001311 0.73076923076923 0.522125210306168 0.884267786708496 0.777777777777777 0.52362723426352 0.935907952282333 0.666666666666666 0.430324517095875 0.854123057656903 12.8942307692307 4.04676331962353 53.8384306173485 5.21203121749785e-07 19 2040 True False 9.99960753532182 4.02234407664723 28.1664238158933 0.00239808153477218 0.0013116543398514 0.00402030313899018 0.99967385733588 0.999328137654343 0.999868864001311 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 9 7 2 10 5 2710 9634 0.00367647058823529 0.0017643752042604999 0.00675073416095428 0.999481273991078 0.998789885214303 0.999831550309162 0.666666666666666 0.383803732541154 0.881758896633119 0.777777777777777 0.399906426283687 0.971855026522101 0.583333333333333 0.276669685682105 0.848347770191569 12.4424354243542 2.36662202142379 122.915867665832 0.000582150986333577 17 1102 True False 0 0 0 0 0 0 0 7.10996309963099 2.21160893375348 26.5326631968869 0.00257637099742362 0.00103644265621341 0.00530106029394105 0.999481273991078 0.998789885214303 0.999831550309162 12 Assoc w RI Marker of R 1) Assoc w R UP from AwRI to AwR yes 4 +Levofloxacin gyrB p.Asn499Ile gyrB_p.Asn499Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 2 1 5 1 5838 21462 0.000855724798904672 0.00027790803803495 0.00199583691247191 0.99995340819084 0.99974043469953 0.999998820398217 0.833333333333333 0.358765421002325 0.99578925548551 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 7.35251798561151 0.382665418086222 432.555198159405 0.117671706664859 77 2040 False False 18.3812949640287 2.0560869984257 865.286471259997 0.000342465753424657 4.14768826827398e-05 0.00123655079603055 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 4 0 2716 9639 0.00147058823529411 0.000400826576335422 0.00376097173045195 1 0.999617369678334 1 1 0.397635364383525 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.666148381584122 Inf 0.048366887932817 36 1102 False False 0 0 0 0 0 0 0 Inf 2.34087544165449 Inf 0.000735835172921265 8.91254790451644e-05 0.00265553611379101 1 0.999617369678334 1 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Asn499Lys gyrB_p.Asn499Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 3 1 6 2 5837 21461 0.0010268697586856 0.000376933373413978 0.00223371319186393 0.99990681638168 0.999663429698698 0.999988714832292 0.75 0.349144205587175 0.968145973750055 0.75 0.194120449683243 0.99369053679029 0.6 0.146632799634673 0.947255049473683 11.0301524755867 0.885359607143637 577.072832635913 0.0328572566047293 52 2040 False False 11.0301524755867 1.97144754924219 111.824924398675 0.000513698630136986 0.000105949538497647 0.00150050427343677 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 2 1 3 2 2717 9637 0.00110294117647058 0.000227510766880298 0.0032198465640147 0.999792509596431 0.999250676427901 0.999974870961701 0.6 0.146632799634673 0.947255049473683 0.666666666666666 0.0942993240502461 0.991596241340387 0.5 0.067585986488543 0.932414013511457 7.09385351490614 0.36909062190608 417.406625549667 0.123918996005032 46 1102 False False 0 0 0 0 0 0 0 5.3203901361796 0.609038002991023 63.7727801541732 0.000735564545788893 8.90926957043619e-05 0.00265456039303256 0.999792509596431 0.999250676427901 0.999974870961701 5 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Asn499Ser gyrB_p.Asn499Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 15 6 5828 21457 0.00256717439671401 0.00143751780890291 0.00423063446053587 0.99972044914504 0.999391635540124 0.999897403075094 0.714285714285714 0.478248881752886 0.887190596078059 0 0 0.521823750104981 0 0 0.4592581264399 0 0 4.01888247932407 0.5915015990606 246 2040 False False 9.20427247769389 3.3725521159076 28.9672605825328 0 0 0.000632757763801925 0.99972044914504 0.999391635540124 0.999897403075094 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 3 4 2717 9635 0.00110294117647058 0.000227510766880298 0.0032198465640147 0.999585019192862 0.998937828281888 0.999886920491758 0.428571428571428 0.0989882784425078 0.815948432359917 0 0 0.707598226178713 0 0 0.602364635616474 0 0 8.58710688065817 1 457.5 1102 False False 0 0 0 0 0 0 0 2.65964298859035 0.389325088875371 15.7282894805178 0 0 0.00135678188642832 0.999585019192862 0.998937828281888 0.999886920491758 15 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Asn499Thr gyrB_p.Asn499Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 22 11 11 31 13 5812 21450 0.00530549375320896 0.00360758765440653 0.00752234173837451 0.99939430648092 0.998964468353895 0.999677455549724 0.704545454545454 0.547978151915944 0.832356018771323 0.5 0.282210520938092 0.717789479061907 0.458333333333333 0.255530201994746 0.671791924304822 3.6906400550585 1.45010903243437 9.38992464098412 0.00274898378434921 30 2040 False False 8.80075705437027 4.47008269308692 18.3358145743175 0.00188906062167267 0.000943377625063785 0.00337753160535534 0.99939430648092 0.998964468353895 0.999677455549724 3) Uncertain significance 1) Assoc w R WHO 1) Assoc w R 1 16 10 6 12 6 2708 9633 0.00441176470588235 0.00228163789982352 0.00769377081358202 0.999377528789293 0.998645638320949 0.999771530871485 0.666666666666666 0.409925238172074 0.866572597493876 0.625 0.354346094302078 0.848016324918877 0.625 0.354346094302078 0.848016324918877 5.92872968980797 1.94988844198452 19.8617097762364 0.000556177577621282 16 1102 True False 0 0 0 0 0 0 0 7.11447562776957 2.46795307899633 23.1197144409894 0.00367917586460632 0.00176567449997898 0.00675569391241004 0.999377528789293 0.998645638320949 0.999771530871485 19 1) Assoc w R UP from Uncertain to AwR yes 4 +Levofloxacin gyrB p.Asn499Tyr gyrB_p.Asn499Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1569 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 855 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 1 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Asn558Asp gyrB_p.Asn558Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Asn666Ser gyrB_p.Asn666Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1547 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Asn66His gyrB_p.Asn66His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Asn66Ser gyrB_p.Asn66Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 0 8 5843 21455 0 0 0.000631133876986172 0.99962726552672 0.99926569731444 0.999839066414514 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 2.15187999193565 0.215644316894169 127.5 2040 False False 0 0 2.15187999193565 0 0 0.000631133876986172 0.99962726552672 0.99926569731444 0.999839066414514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 8 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Asp110Gly gyrB_p.Asp110Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Asp112His gyrB_p.Asp112His 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89146792489366 1 319.5 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 2 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Asp176Glu gyrB_p.Asp176Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Asp216Gly gyrB_p.Asp216Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Asp220Glu gyrB_p.Asp220Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Asp225Glu gyrB_p.Asp225Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Asp225Gly gyrB_p.Asp225Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Asp259Glu gyrB_p.Asp259Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 2 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Asp334Gly gyrB_p.Asp334Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Asp340Gly gyrB_p.Asp340Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1572 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 857 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Asp342Glu gyrB_p.Asp342Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.56487735727821 0.58431003819195 215.5 2040 False False 0 0 5.56487735727821 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.57852451631077 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 8.57852451631077 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 3 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Asp402Glu gyrB_p.Asp402Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Asp434Glu gyrB_p.Asp434Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Asp434Gly gyrB_p.Asp434Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 5843 21458 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.0087500478358 0.59157266040946 268 2040 False False 0 0 4.0087500478358 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Asp434His gyrB_p.Asp434His 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Asp461Ala gyrB_p.Asp461Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 5 1 5838 21462 0.000855724798904672 0.00027790803803495 0.00199583691247191 0.99995340819084 0.99974043469953 0.999998820398217 0.833333333333333 0.358765421002325 0.99578925548551 0 0 0.975 0 0 0.975 0 0 143.062509965765 1 883 2040 False False 18.3812949640287 2.0560869984257 865.286471259997 0 0 0.000631674245690789 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 5 0 2715 9639 0.00183823529411764 0.000597130943349739 0.00428457163587036 1 0.999617369678334 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 828 1102 False False 0 0 0 0 0 0 0 Inf 3.25048589412313 Inf 0 0 0.00135778067859282 1 0.999617369678334 1 3 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Asp461Asn gyrB_p.Asp461Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 45 27 18 44 18 5799 21445 0.00753037823036111 0.00547676194208522 0.0100961341914554 0.99916134743512 0.998674889990656 0.999502887997069 0.709677419354838 0.580509799043354 0.818005964132128 0.6 0.443313512479002 0.743024104807368 0.6 0.443313512479002 0.743024104807368 5.54707708225556 2.94230260442485 10.7001315018013 2.08095255924479e-08 14 2040 True False 9.03968117108313 5.11239369162307 16.6359357320022 0.00463439752832131 0.00305625187312015 0.0067356939947728 0.99916134743512 0.998674889990656 0.999502887997069 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 25 16 9 22 9 2698 9630 0.00808823529411764 0.00507559482038076 0.0122202167587801 0.99906629318394 0.998228276906464 0.999572963722204 0.709677419354838 0.51963934177109 0.857771470902474 0.64 0.425206349553849 0.820283179416344 0.64 0.425206349553849 0.820283179416344 6.34544106745737 2.63640966073825 16.3036506907052 7.36960538917464e-06 10 1102 True False 0 0 0 0 0 0 0 8.72498146775389 3.85474314868789 21.5474164176252 0.00589535740604274 0.00337334891948777 0.00955608080421777 0.99906629318394 0.998228276906464 0.999572963722204 11 Assoc w RI 1) Assoc w R UP from AwRI to AwR yes 4 +Levofloxacin gyrB p.Asp461His gyrB_p.Asp461His 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 7 2 19 4 5824 21459 0.00325175423583775 0.00195886894634834 0.00507337943019098 0.99981363276336 0.999522895233871 0.999949218940757 0.826086956521739 0.612188110045202 0.950492354694206 0.777777777777777 0.399906426283687 0.971855026522101 0.636363636363636 0.307904715011677 0.890736556180901 12.8960336538461 2.45425504225253 127.404442423238 0.00048285155765643 25 2040 True False 17.5017599587912 5.81178937700333 70.6955827668072 0.00120048019207683 0.000482787208573135 0.00247187394062219 0.99981363276336 0.999522895233871 0.999949218940757 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance 1 8 6 2 16 4 2704 9635 0.00588235294117647 0.00336589967267386 0.00953503998064353 0.999585019192862 0.998937828281888 0.999886920491758 0.8 0.563385997003331 0.942666002949967 0.75 0.349144205587175 0.968145973750055 0.6 0.262378076606945 0.878447741880172 10.6897189349112 1.90962225703391 108.379435493444 0.00205837020727918 21 1102 False False 0 0 0 0 0 0 0 14.2529585798816 4.59209576488274 58.6320798484493 0.0022140221402214 0.000812926950392949 0.00481271973422639 0.999585019192862 0.998937828281888 0.999886920491758 4 Evidence from ALL dataset only 2) Assoc w R - Interim UP from Uncertain to AwRI yes ALL only 4 +Levofloxacin gyrB p.Asp461Val gyrB_p.Asp461Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 1 5841 21462 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99995340819084 0.99974043469953 0.999998820398217 0.666666666666666 0.0942993240502461 0.991596241340387 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0941984244079002 Inf 0.21396132434808 91 2040 False False 7.3487416538264 0.382468755528661 432.333734199629 0.000171174255391989 4.33374753915718e-06 0.000953348826018904 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 2718 9639 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 1 0.999617369678334 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0908987145025996 Inf 0.220019420618223 71.5 1102 False False 0 0 0 0 0 0 0 Inf 0.665658435310444 Inf 0.000367782272894446 9.31139761383543e-06 0.00204742980952803 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Asp472Asn gyrB_p.Asp472Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1573 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 858 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Asp494Ala gyrB_p.Asp494Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 2 3 5841 21460 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99986022457252 0.999591571764338 0.999971174018896 0.4 0.0527449505263169 0.853367200365326 0 0 0.841886116991581 0 0 0.707598226178713 0 0 19.5733512949936 1 883 2040 False False 2.44935227986075 0.204519727205419 21.3860749684357 0 0 0.000631349913487419 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 2 3 2718 9636 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 0.999688764394646 0.999090709558603 0.999935811136198 0.4 0.0527449505263169 0.853367200365326 0 0 0.841886116991581 0 0 0.707598226178713 0 0 18.882849968852 1 457.5 1102 False False 0 0 0 0 0 0 0 2.3635025754231 0.197291785205426 20.6413600392426 0 0 0.00135628304118183 0.999688764394646 0.999090709558603 0.999935811136198 2 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Asp518Gly gyrB_p.Asp518Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Asp588Asn gyrB_p.Asp588Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1528 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Asp617Tyr gyrB_p.Asp617Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 4 3 5839 21460 0.000684579839123737 0.000186555462570677 0.00175186028923716 0.99986022457252 0.999591571764338 0.999971174018896 0.571428571428571 0.184051567640083 0.901011721557492 0 0 0.841886116991581 0 0 0.707598226178713 0 0 19.580035851571 1 883 2040 False False 4.90038248558543 0.828712385488626 33.4355470146126 0 0 0.000631566097937464 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 2718 9638 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 0.999896254798215 0.999422105789591 0.999997373402351 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 138.011851332821 1 457.5 1102 False False 0 0 0 0 0 0 0 7.09197939661515 0.368993183584618 417.296682266591 0 0 0.00135628304118183 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Asp627Ala gyrB_p.Asp627Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89146792489366 1 319.5 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.57852451631077 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 8.57852451631077 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Asp640Ala gyrB_p.Asp640Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Asp645Ala gyrB_p.Asp645Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1563 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Asp645Glu gyrB_p.Asp645Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1516 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 824 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Asp669fs gyrB_p.Asp669fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Asp97Glu gyrB_p.Asp97Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.56487735727821 0.58431003819195 215.5 2040 False False 0 0 5.56487735727821 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.57852451631077 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 8.57852451631077 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 2 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Cys388Gly gyrB_p.Cys388Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Gln476Glu gyrB_p.Gln476Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Gln4Arg gyrB_p.Gln4Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Gln503Arg gyrB_p.Gln503Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1519 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 826 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Gln538Arg gyrB_p.Gln538Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1555 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 847 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Gln565His gyrB_p.Gln565His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Gln9His gyrB_p.Gln9His 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 1 2 5842 21461 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99990681638168 0.999663429698698 0.999988714832292 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 1.83678534748373 0.0311281139040964 35.2896458967866 0.514394017317937 195.5 2040 False False 1.83678534748373 0.0311281139040964 35.2896458967866 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0908652957857324 Inf 0.220082530949106 80 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 5 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Glu151Asp gyrB_p.Glu151Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Glu181Gly gyrB_p.Glu181Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Glu21Asp gyrB_p.Glu21Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Glu21Gln gyrB_p.Glu21Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Glu21Lys gyrB_p.Glu21Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Glu228Asp gyrB_p.Glu228Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 2 3 5841 21460 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99986022457252 0.999591571764338 0.999971174018896 0.4 0.0527449505263169 0.853367200365326 0 0 0.841886116991581 0 0 0.707598226178713 0 0 19.5733512949936 1 883 2040 False False 2.44935227986075 0.204519727205419 21.3860749684357 0 0 0.000631349913487419 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 2 3 2718 9636 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 0.999688764394646 0.999090709558603 0.999935811136198 0.4 0.0527449505263169 0.853367200365326 0 0 0.841886116991581 0 0 0.707598226178713 0 0 18.882849968852 1 457.5 1102 False False 0 0 0 0 0 0 0 2.3635025754231 0.197291785205426 20.6413600392426 0 0 0.00135628304118183 0.999688764394646 0.999090709558603 0.999935811136198 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Glu228Gln gyrB_p.Glu228Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 2 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Glu299Gln gyrB_p.Glu299Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Glu364Asp gyrB_p.Glu364Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1529 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Glu379Gly gyrB_p.Glu379Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Glu397Asp gyrB_p.Glu397Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 5841 21463 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 1 0.999828143201531 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1525 2040 False False Inf 0.689929368506768 Inf 0 0 0.000631349913487419 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Glu425Ala gyrB_p.Glu425Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Glu489Gln gyrB_p.Glu489Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Glu501Ala gyrB_p.Glu501Ala 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 0 1 3 1 5840 21462 0.000513434879342803 0.000105895133877182 0.00149973424244328 0.99995340819084 0.99974043469953 0.999998820398217 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 143.013625436925 1 883 2040 False False 11.025 0.884946155157416 576.804300084131 0 0 0.000631457987209345 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 0 1 2 1 2718 9638 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 0.999896254798215 0.999422105789591 0.999997373402351 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 138.011851332821 1 457.5 1102 False False 0 0 0 0 0 0 0 7.09197939661515 0.368993183584618 417.296682266591 0 0 0.00135628304118183 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Glu501Asp gyrB_p.Glu501Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 44 13 31 45 33 5798 21430 0.00770152319014205 0.00562293077790513 0.0102918148614796 0.998462470297721 0.997841408000016 0.998941406264571 0.576923076923076 0.459758424224533 0.688067236956963 0.295454545454545 0.167643981228676 0.452021848084055 0.282608695652173 0.159866701924902 0.43460407778425 1.54997830175032 0.743908182420325 3.05122784164012 0.196284644854778 88 2040 False False 5.04013923296434 3.14197270511835 8.15939493154125 0.00223713646532438 0.00119170187200361 0.00382253318374497 0.998462470297721 0.997841408000016 0.998941406264571 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 18 0 18 18 18 2702 9621 0.00661764705882352 0.00392661369638335 0.0104386434854847 0.99813258636788 0.997050280966737 0.998892888551341 0.5 0.32922179945771 0.670778200542289 0 0 0.185301968137852 0 0 0.185301968137852 0 0 0.810564824319004 0.0196045341452225 30 1102 False False 0 0 0 0 0 0 0 3.56069578090303 1.74470190315524 7.26494642148159 0 0 0.00136430884385783 0.99813258636788 0.997050280966737 0.998892888551341 30 Assoc w RI FQ cross-resistance 2) Assoc w R - Interim No change yes FQ X-R 1 +Levofloxacin gyrB p.Glu501Gly gyrB_p.Glu501Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 142.964774304408 1 883 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0 0 0.00063124187675269 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Glu501Val gyrB_p.Glu501Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Assoc w RI Marker of R WHO-endorsed gDST assay 2) Assoc w R - Interim no change yes WHO-end. gDST 1 +Levofloxacin gyrB p.Glu586Lys gyrB_p.Glu586Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 1 3 1 4 5842 21459 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99981363276336 0.999522895233871 0.999949218940757 0.2 0.00505076337946806 0.716417936118089 0.25 0.00630946320970987 0.805879550316756 0.2 0.00505076337946806 0.716417936118089 1.22440944881889 0.0233192537072192 15.2505288096408 1 883 2040 False False 0.918307086614173 0.0186435710006194 9.27999188457764 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 3.54468554615667 0.045140524816893 277.645286351599 0.391742630950597 101.5 1102 False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 11 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Glu604Gly gyrB_p.Glu604Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1545 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 839 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Glu604Lys gyrB_p.Glu604Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Glu604Val gyrB_p.Glu604Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Glu623Asp gyrB_p.Glu623Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1532 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Glu654Ala gyrB_p.Glu654Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 5 5843 21458 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1523 2040 False False 0 0 4.0087500478358 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 830 1102 False False 0 0 0 0 0 0 0 0 0 8.57852451631077 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 3 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Glu71Asp gyrB_p.Glu71Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Glu76Asp gyrB_p.Glu76Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Gly203Val gyrB_p.Gly203Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Gly282Asp gyrB_p.Gly282Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.56487735727821 0.58431003819195 215.5 2040 False False 0 0 5.56487735727821 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.57852451631077 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 8.57852451631077 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 3 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Gly38Ser gyrB_p.Gly38Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89146792489366 1 319.5 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Gly436Arg gyrB_p.Gly436Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Gly437Ala gyrB_p.Gly437Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Gly470Cys gyrB_p.Gly470Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 5841 21463 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 1 0.999828143201531 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1542 2040 False False Inf 0.689929368506768 Inf 0 0 0.000631349913487419 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Gly510Asp gyrB_p.Gly510Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Gly512Arg gyrB_p.Gly512Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 35 3 32 25 33 5818 21430 0.00427862399452336 0.00277075594853414 0.00630965649421625 0.998462470297721 0.997841408000016 0.998941406264571 0.43103448275862 0.3016245422922 0.567730183319102 0.0857142857142857 0.0180376398142174 0.230575018658877 0.0833333333333333 0.0175264959239346 0.224689760556973 0.345318408387762 0.067633850958471 1.10445794700981 0.06520608142798 63 2040 False False 2.79045178495161 1.58937155639262 4.84106631606384 0.00051537536505755 0.00010629540349504 0.00150539955897188 0.998462470297721 0.997841408000016 0.998941406264571 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 28 3 25 20 25 2700 9614 0.00735294117647058 0.00449698352187646 0.0113332827880076 0.997406369955389 0.996173655269493 0.998320857770214 0.444444444444444 0.296443923865858 0.600026503596321 0.107142857142857 0.0226650906390589 0.282264395715324 0.107142857142857 0.0226650906390589 0.282264395715324 0.427288888888888 0.0825156953794357 1.40201707650576 0.176152918650963 57 1102 False False 0 0 0 0 0 0 0 2.84859259259259 1.49760824516406 5.35053116707615 0.00110987791342952 0.000228942018054309 0.00324007556457336 0.997406369955389 0.996173655269493 0.998320857770214 8 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Gly520Ala gyrB_p.Gly520Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 40 5842 21423 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.998136327633602 0.997463062772638 0.998668241626459 0.024390243902439 0.000617316893286519 0.128554020384146 NA NA NA 0 0 0.0880973028788023 NA NA NA NA 1548 2040 False True 0.0916766518315645 0.0022687064665794 0.541232191108522 0 0 0.00063124187675269 0.998136327633602 0.997463062772638 0.998668241626459 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 1 36 2719 9603 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.996265172735761 0.994833138133342 0.997382843293988 0.027027027027027 0.000684031024694665 0.141603095611158 NA NA NA 0 0 0.0973937559144919 NA NA NA NA 841 1102 False True 0 0 0 1 0 0 0 0.0981059212945936 0.0024205810741147 0.58323269721147 0 0 0.0013557845626193 0.996265172735761 0.994833138133342 0.997382843293988 15 5) Not assoc w R UP from Uncertain to NotAwR yes 4 +Levofloxacin gyrB p.Gly520Val gyrB_p.Gly520Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1570 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Gly589Val gyrB_p.Gly589Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 3.67374186922286 0.0467931454016956 287.712465214691 0.382182295738733 180 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Gly594Arg gyrB_p.Gly594Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Gly598Glu gyrB_p.Gly598Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.56487735727821 0.58431003819195 215.5 2040 False False 0 0 5.56487735727821 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Gly606Ser gyrB_p.Gly606Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89146792489366 1 319.5 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 5 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.His252Tyr gyrB_p.His252Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.His272Pro gyrB_p.His272Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.His285Arg gyrB_p.His285Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.His302Arg gyrB_p.His302Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 18 0 18 9 20 5834 21443 0.00154030463802841 0.000704559638966774 0.00292195530235611 0.999068163816801 0.998561219655491 0.999430720271997 0.310344827586206 0.152845939608631 0.50832335380999 0 0 0.185301968137852 0 0 0.168433470983085 0 0 0.836319067980283 0.019918175346272 43 2040 False False 1.65398525882756 0.662764801875004 3.80233193386571 0 0 0.000632107207336799 0.999068163816801 0.998561219655491 0.999430720271997 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 2 8 2718 9631 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 0.999170038385724 0.99836530325407 0.99964161554927 0.2 0.0252107263268333 0.556095462307641 0 0 0.369416647552819 0 0 0.369416647552819 0 0 2.07735248186824 0.213357151327656 66 1102 False False 0 0 0 0 0 0 0 0.885853568800588 0.0915913755002862 4.44256972601755 0 0 0.00135628304118183 0.999170038385724 0.99836530325407 0.99964161554927 20 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.His311Arg gyrB_p.His311Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1557 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 849 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.His560Arg gyrB_p.His560Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.His560Asn gyrB_p.His560Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ile116Met gyrB_p.Ile116Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ile19Leu gyrB_p.Ile19Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ile206Ser gyrB_p.Ile206Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 8.89105370607792 1 883 2040 False False 0 0 5.56487735727821 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.57852451631077 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 8.57852451631077 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ile271Met gyrB_p.Ile271Met 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 14 100 5829 21363 0.00239602943693308 0.0013105314105045 0.00401686566193227 0.995340819084005 0.994336044933772 0.996207544674002 0.122807017543859 0.0687943256819478 0.1974590145418 NA NA NA 0 0 0.0362166926451764 NA NA NA NA 1583 2040 False False 0.513093154915079 0.270555454710077 0.90259378021133 0 0 0.000632649244748106 0.995340819084005 0.994336044933772 0.996207544674002 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 7 3 2713 9636 0.0025735294117647 0.0010352988504908 0.00529522151968195 0.999688764394646 0.999090709558603 0.999935811136198 0.7 0.347547149940002 0.933260488822265 NA NA NA 0 0 0.707598226178713 NA NA NA NA 863 1102 False False 0 0 0 0 0 0 0 8.28750460744563 1.89007708426738 49.7180602938531 0 0 0.00135878094235795 0.999688764394646 0.999090709558603 0.999935811136198 69 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ile271Val gyrB_p.Ile271Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ile34Val gyrB_p.Ile34Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 1 8 5842 21455 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99962726552672 0.99926569731444 0.999839066414514 0.111111111111111 0.00280913674659921 0.482496514917337 0 0 0.369416647552819 0 0 0.369416647552819 0 0 2.1522485685766 0.215656865655095 131.5 2040 False False 0.45906795617939 0.0103475211102756 3.425357676166 0 0 0.00063124187675269 0.99962726552672 0.99926569731444 0.999839066414514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 137.961202437293 1 457.5 1102 False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 0 0 0.0013557845626193 0.999896254798215 0.999422105789591 0.999997373402351 3 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ile435Val gyrB_p.Ile435Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ile46Ser gyrB_p.Ile46Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ile478Leu gyrB_p.Ile478Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Ile486Leu gyrB_p.Ile486Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 6 2 5837 21461 0.0010268697586856 0.000376933373413978 0.00223371319186393 0.99990681638168 0.999663429698698 0.999988714832292 0.75 0.349144205587175 0.968145973750055 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.587634906998 1 883 2040 False False 11.0301524755867 1.97144754924219 111.824924398675 0 0 0.000631782430488341 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 1 2717 9638 0.00110294117647058 0.000227510766880298 0.0032198465640147 0.999896254798215 0.999422105789591 0.999997373402351 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 138.062537430878 1 457.5 1102 False False 0 0 0 0 0 0 0 10.6418844313581 0.853871105694195 556.864474256822 0 0 0.00135678188642832 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ile486Val gyrB_p.Ile486Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ile493Thr gyrB_p.Ile493Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 16 5843 21447 0 0 0.000631133876986172 0.99925453105344 0.998789686679379 0.999573841954248 0 0 0.205907214207822 NA NA NA 0 0 0.205907214207822 NA NA NA NA 1509 2040 False False 0 0 0.952125276634789 0 0 0.000631133876986172 0.99925453105344 0.998789686679379 0.999573841954248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 2720 9633 0 0 0.00135528645033659 0.999377528789293 0.998645638320949 0.999771530871485 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 820 1102 False False 0 0 0 0 0 0 0 0 0 3.00974784500922 0 0 0.00135528645033659 0.999377528789293 0.998645638320949 0.999771530871485 46 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ile505Val gyrB_p.Ile505Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1551 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 843 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 8 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ile506Met gyrB_p.Ile506Met 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1539 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 836 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Ile527Val gyrB_p.Ile527Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Ile556Val gyrB_p.Ile556Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 5842 21460 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99986022457252 0.999591571764338 0.999971174018896 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89298982087011 1 883 2040 False False 1.22446650690402 0.0233203404016305 15.2512395040111 0 0 0.00063124187675269 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 1 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ile601Thr gyrB_p.Ile601Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ile607Val gyrB_p.Ile607Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.56487735727821 0.58431003819195 215.5 2040 False False 0 0 5.56487735727821 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.57852451631077 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 8.57852451631077 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 25 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ile84Val gyrB_p.Ile84Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 32 0 32 0 32 5843 21431 0 0 0.000631133876986172 0.998509062106881 0.997895886619693 0.998979982994274 0 0 0.108881160679352 0 0 0.108881160679352 0 0 0.108881160679352 0 0 0.448337315806146 0.00077312418824587 27 2040 False False 0 0 0.448337315806146 0 0 0.000631133876986172 0.998509062106881 0.997895886619693 0.998979982994274 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 18 0 18 0 18 2720 9621 0 0 0.00135528645033659 0.99813258636788 0.997050280966737 0.998892888551341 0 0 0.185301968137852 0 0 0.185301968137852 0 0 0.185301968137852 0 0 0.805197693249005 0.019589803682533 29 1102 False False 0 0 0 0 0 0 0 0 0 0.805197693249005 0 0 0.00135528645033659 0.99813258636788 0.997050280966737 0.998892888551341 14 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ile93Val gyrB_p.Ile93Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 16 5843 21447 0 0 0.000631133876986172 0.99925453105344 0.998789686679379 0.999573841954248 0 0 0.205907214207822 NA NA NA 0 0 0.205907214207822 NA NA NA NA 1552 2040 False False 0 0 0.952125276634789 0 0 0.000631133876986172 0.99925453105344 0.998789686679379 0.999573841954248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 2720 9633 0 0 0.00135528645033659 0.999377528789293 0.998645638320949 0.999771530871485 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 844 1102 False False 0 0 0 0 0 0 0 0 0 3.00974784500922 0 0 0.00135528645033659 0.999377528789293 0.998645638320949 0.999771530871485 47 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Leu156Arg gyrB_p.Leu156Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Leu156Met gyrB_p.Leu156Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Leu204Met gyrB_p.Leu204Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1517 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Leu257Pro gyrB_p.Leu257Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 5841 21463 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 1 0.999828143201531 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1543 2040 False False Inf 0.689929368506768 Inf 0 0 0.000631349913487419 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Leu337Arg gyrB_p.Leu337Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Leu354Val gyrB_p.Leu354Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Leu375Phe gyrB_p.Leu375Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1556 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 848 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Leu375Val gyrB_p.Leu375Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1533 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Leu42Ile gyrB_p.Leu42Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1584 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 864 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Leu455Val gyrB_p.Leu455Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Leu509Pro gyrB_p.Leu509Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0941866911272879 Inf 0.213982274957884 105.5 2040 False False Inf 0.0941866911272879 Inf 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Leu522Val gyrB_p.Leu522Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 5841 21463 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 1 0.999828143201531 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1511 2040 False False Inf 0.689929368506768 Inf 0 0 0.000631349913487419 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 2718 9639 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 1 0.999617369678334 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 822 1102 False False 0 0 0 0 0 0 0 Inf 0.665658435310444 Inf 0 0 0.00135628304118183 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Leu555Phe gyrB_p.Leu555Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Leu555Val gyrB_p.Leu555Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Leu563Phe gyrB_p.Leu563Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Leu571Ile gyrB_p.Leu571Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1540 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Leu638Val gyrB_p.Leu638Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Leu673Pro gyrB_p.Leu673Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Leu69Val gyrB_p.Leu69Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Lys159Met gyrB_p.Lys159Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Lys165Asn gyrB_p.Lys165Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1510 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 821 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Lys333Arg gyrB_p.Lys333Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Lys404Arg gyrB_p.Lys404Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 142.964774304408 1 883 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0 0 0.00063124187675269 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 845 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Lys430Asn gyrB_p.Lys430Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1512 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Lys452Asn gyrB_p.Lys452Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Lys498Asn gyrB_p.Lys498Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Lys526Asn gyrB_p.Lys526Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Lys526Gln gyrB_p.Lys526Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 25 1 24 2 25 5841 21438 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.998835204771001 0.998281009378759 0.999246068539694 0.074074074074074 0.00910007294230628 0.242898346845627 0.04 0.00101219969931084 0.203516913922414 0.0384615384615384 0.00097328789333503 0.196369646762539 0.152927580893682 0.00372192783397874 0.938235626753692 0.0283385968036638 48 2040 False False 0.29362095531587 0.0336903230803465 1.17812605073931 0.000171174255391989 4.33374753915718e-06 0.000953348826018904 0.998835204771001 0.998281009378759 0.999246068539694 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 0 10 2720 9629 0 0 0.00135528645033659 0.998962547982155 0.998092919138308 0.999502392880449 0 0 0.30849710781876 0 0 0.30849710781876 0 0 0.30849710781876 0 0 1.58051507062204 0.131074447037169 50.5 1102 False False 0 0 0 0 0 0 0 0 0 1.58051507062204 0 0 0.00135528645033659 0.998962547982155 0.998092919138308 0.999502392880449 44 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Lys596Asn gyrB_p.Lys596Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89146792489366 1 319.5 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.57852451631077 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 8.57852451631077 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 4 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Lys599Arg gyrB_p.Lys599Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1558 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 850 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Lys603Arg gyrB_p.Lys603Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Lys668Arg gyrB_p.Lys668Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Lys668Glu gyrB_p.Lys668Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Lys7Gln gyrB_p.Lys7Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Met100Val gyrB_p.Met100Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 1 5840 21462 0.000513434879342803 0.000105895133877182 0.00149973424244328 0.99995340819084 0.99974043469953 0.999998820398217 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 143.013625436925 1 883 2040 False False 11.025 0.884946155157416 576.804300084131 0 0 0.000631457987209345 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 137.961202437293 1 457.5 1102 False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 0 0 0.0013557845626193 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Met197Ile gyrB_p.Met197Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1534 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 834 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Met291Ile gyrB_p.Met291Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 115 1516 5728 19947 0.0196816703748074 0.0162758983557803 0.0235781228174651 0.929366817313516 0.92585732531601 0.932759475465322 0.0705088902513795 0.0585601348990678 0.0840297443964976 0 0 0.841886116991581 0 0 0.00243033972365082 0 0 18.5450407802936 1 NA NA False True 0.264163747770522 0.216096612654138 0.320259921714665 0 0 0.000643800955761171 0.929366817313516 0.92585732531601 0.932759475465322 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 2 0 2 42 519 2678 9120 0.0154411764705882 0.0111507100933312 0.0208152016333473 0.946156240273887 0.941461886799081 0.95057863235785 0.0748663101604278 0.0544869040841155 0.099852471402978 0 0 0.841886116991581 0 0 0.00708246781181742 0 0 18.1389720084366 1 NA NA False True 0 1 1 0 0 1 0 0.2755917408816 0.195688516884097 0.379089547183147 0 0 0.00137652724036696 0.946156240273887 0.941461886799081 0.95057863235785 2856 Not assoc w R 5) Not assoc w R No change yes 1 +Levofloxacin gyrB p.Met530Thr gyrB_p.Met530Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Met58Ile gyrB_p.Met58Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 5843 21457 0 0 0.000631133876986172 0.99972044914504 0.999391635540124 0.999897403075094 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.1200699364824 0.35257212959262 148.5 2040 False False 0 0 3.1200699364824 0 0 0.000631133876986172 0.99972044914504 0.999391635540124 0.999897403075094 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 2720 9633 0 0 0.00135528645033659 0.999377528789293 0.998645638320949 0.999771530871485 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.00974784500922 0.35000722127353 94 1102 False False 0 0 0 0 0 0 0 0 0 3.00974784500922 0 0 0.00135528645033659 0.999377528789293 0.998645638320949 0.999771530871485 1 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Met616Val gyrB_p.Met616Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Phe187Leu gyrB_p.Phe187Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1544 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 838 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Phe549Leu gyrB_p.Phe549Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Pro163Leu gyrB_p.Pro163Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Pro163Ser gyrB_p.Pro163Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89146792489366 1 319.5 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.57852451631077 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 8.57852451631077 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 4 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Pro177Arg gyrB_p.Pro177Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 142.93371627475 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 137.896313968788 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Pro177His gyrB_p.Pro177His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Pro177Leu gyrB_p.Pro177Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 8.89105370607792 1 883 2040 False False 0 0 5.56487735727821 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 4 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Pro243Ser gyrB_p.Pro243Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0941866911272879 Inf 0.213982274957884 105.5 2040 False False Inf 0.0941866911272879 Inf 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Pro254Leu gyrB_p.Pro254Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 1 7 1 7 5842 21456 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99967385733588 0.999328137654343 0.999868864001311 0.125 0.0031597235312519 0.526509670875206 0.125 0.0031597235312519 0.526509670875206 0.125 0.0031597235312519 0.526509670875206 0.524673546241502 0.0116431407170618 4.08534979936462 1 883 2040 False False 0.524673546241502 0.0116431407170618 4.08534979936462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99967385733588 0.999328137654343 0.999868864001311 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 1 4 1 4 2719 9635 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999585019192862 0.998937828281888 0.999886920491758 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 0.885895549834498 0.0179820541723419 8.95537117058933 1 457.5 1102 False False 0 0 0 0 0 0 0 0.885895549834498 0.0179820541723419 8.95537117058933 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999585019192862 0.998937828281888 0.999886920491758 1 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Pro343Ala gyrB_p.Pro343Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Pro343Leu gyrB_p.Pro343Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89146792489366 1 319.5 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.57852451631077 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 8.57852451631077 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Pro343Ser gyrB_p.Pro343Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Pro400Arg gyrB_p.Pro400Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.56487735727821 0.58431003819195 215.5 2040 False False 0 0 5.56487735727821 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 47 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Pro439Ala gyrB_p.Pro439Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Pro439Arg gyrB_p.Pro439Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Pro450Arg gyrB_p.Pro450Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 5840 21463 0.000513434879342803 0.000105895133877182 0.00149973424244328 1 0.999828143201531 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1571 2040 False False Inf 1.51820267072123 Inf 0 0 0.000631457987209345 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 2718 9639 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 1 0.999617369678334 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 856 1102 False False 0 0 0 0 0 0 0 Inf 0.665658435310444 Inf 0 0 0.00135628304118183 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Pro480Ser gyrB_p.Pro480Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1564 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Pro578Ala gyrB_p.Pro578Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 5843 21458 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.0087500478358 0.59157266040946 268 2040 False False 0 0 4.0087500478358 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 1 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Pro578Arg gyrB_p.Pro578Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Pro578Ser gyrB_p.Pro578Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0941866911272879 Inf 0.213982274957884 105.5 2040 False False Inf 0.0941866911272879 Inf 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Pro628Ala gyrB_p.Pro628Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 1 4 5842 21459 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99981363276336 0.999522895233871 0.999949218940757 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.56583008746417 0.58432028936451 238 2040 False False 0.918307086614173 0.0186435710006194 9.27999188457764 0 0 0.00063124187675269 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 12 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Pro94Leu gyrB_p.Pro94Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 14 517 5829 20946 0.00239602943693308 0.0013105314105045 0.00401686566193227 0.975912034664306 0.973771924955098 0.977921876502366 0.0263653483992467 0.0144874952161763 0.0438412111168694 NA NA NA 0 0 0.00710976851082123 NA NA NA NA NA NA False True 0.0973071015229992 0.0527897169269079 0.164916894645909 0 0 0.000632649244748106 0.975912034664306 0.973771924955098 0.977921876502366 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 5 206 2715 9433 0.00183823529411764 0.000597130943349739 0.00428457163587036 0.97862848843241 0.975540700578364 0.981422102414396 0.0236966824644549 0.00773800968627835 0.0544308246345451 NA NA NA 0 0 0.0177478010074704 NA NA NA NA NA NA False True 1 1 1 0 0 1 0 0.0843301328470024 0.0270887959457118 0.200326838833232 0 0 0.00135778067859282 0.97862848843241 0.975540700578364 0.981422102414396 211 Not assoc w R 5) Not assoc w R No change yes 1 +Levofloxacin gyrB p.Ser16Cys gyrB_p.Ser16Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1546 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 840 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ser248Gly gyrB_p.Ser248Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ser273Gly gyrB_p.Ser273Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Ser274Arg gyrB_p.Ser274Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 15 2 13 9 14 5834 21449 0.00154030463802841 0.000704559638966774 0.00292195530235611 0.99934771467176 0.998905818000026 0.999643345117175 0.391304347826087 0.197076423969014 0.61458104261115 0.133333333333333 0.0165759134400836 0.404602696603372 0.125 0.0155136038154138 0.383476236849263 0.565623269428548 0.0619525963983079 2.49968914825496 0.751944529359121 284 2040 False False 2.36349723296929 0.901882018158228 5.86586637074143 0.000342700479780671 4.15053128239407e-05 0.00123739794975501 0.99934771467176 0.998905818000026 0.999643345117175 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 14 2 12 8 12 2712 9627 0.00294117647058823 0.00127061997302132 0.00578702225151795 0.998755057578587 0.997826347023296 0.999356559855396 0.4 0.191190060725307 0.63945741269251 0.142857142857142 0.0177945154831915 0.428129160909698 0.142857142857142 0.0177945154831915 0.428129160909698 0.591629793510324 0.0642746031850472 2.66009478004313 0.747820497278406 142 1102 False False 0 0 0 0 0 0 0 2.36651917404129 0.838136822352612 6.30257626441913 0.000736919675755342 8.9256854029008e-05 0.00265944618017881 0.998755057578587 0.997826347023296 0.999356559855396 5 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ser274Gly gyrB_p.Ser274Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89146792489366 1 319.5 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.57852451631077 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 8.57852451631077 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 12 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Ser274Thr gyrB_p.Ser274Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ser298Ala gyrB_p.Ser298Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1559 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 851 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Ser359Thr gyrB_p.Ser359Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ser363Arg gyrB_p.Ser363Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 1 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ser413Ala gyrB_p.Ser413Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ser447Phe gyrB_p.Ser447Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 32 16 16 21 19 5822 21444 0.00359404415539962 0.00222610454413391 0.00548865843522298 0.999114755625961 0.998617924918733 0.999466943572351 0.525 0.361280135264062 0.684880293365014 0.5 0.318874964234163 0.681125035765836 0.457142857142857 0.288271443790756 0.633541982878547 3.68327035383029 1.72310292211097 7.87241726892927 0.000322504644884322 24 2040 True False 4.07098302265454 2.08162051648476 8.01120930041991 0.0027406646111682 0.00156731294649428 0.00444686203223802 0.999114755625961 0.998617924918733 0.999466943572351 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance 1 25 13 12 15 12 2705 9627 0.00551470588235294 0.00308972573905283 0.00907938157352261 0.998755057578587 0.997826347023296 0.999356559855396 0.555555555555555 0.353264230322005 0.745201193368262 0.52 0.313057044457032 0.722031990330053 0.52 0.313057044457032 0.722031990330053 3.85554528650646 1.6195388285576 9.25439169767133 0.000957323949590561 19 1102 False False 0 0 0 0 0 0 0 4.44870609981515 1.94106637629505 10.4232966667776 0.00478292862398822 0.00254909152855224 0.00816506594453436 0.998755057578587 0.997826347023296 0.999356559855396 15 Evidence from ALL dataset only 2) Assoc w R - Interim UP from Uncertain to AwRI yes ALL only 4 +Levofloxacin gyrB p.Ser447Tyr gyrB_p.Ser447Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 4 5 4 6 5839 21457 0.000684579839123737 0.000186555462570677 0.00175186028923716 0.99972044914504 0.999391635540124 0.999897403075094 0.4 0.121552258119827 0.737621923393055 0.444444444444444 0.136995662265166 0.787991493221131 0.4 0.121552258119827 0.737621923393055 2.93981846206542 0.58312795790839 13.6588356499395 0.105216540609161 75 2040 False False 2.44984871838785 0.508289026438214 10.3326821293772 0.000684579839123737 0.000186555462570677 0.00175186028923716 0.99972044914504 0.999391635540124 0.999897403075094 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 3 3 3 4 2717 9635 0.00110294117647058 0.000227510766880298 0.0032198465640147 0.999585019192862 0.998937828281888 0.999886920491758 0.428571428571428 0.0989882784425078 0.815948432359917 0.5 0.118117248757025 0.881882751242974 0.428571428571428 0.0989882784425078 0.815948432359917 3.5461906514538 0.474634240988141 26.4878781275022 0.125052193948299 47 1102 False False 0 0 0 0 0 0 0 2.65964298859035 0.389325088875371 15.7282894805178 0.00110294117647058 0.000227510766880298 0.0032198465640147 0.999585019192862 0.998937828281888 0.999886920491758 3 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ser466Pro gyrB_p.Ser466Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ser576Gly gyrB_p.Ser576Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89146792489366 1 319.5 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ser576Ile gyrB_p.Ser576Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 0 8 5843 21455 0 0 0.000631133876986172 0.99962726552672 0.99926569731444 0.999839066414514 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 2.15187999193565 0.215644316894169 127.5 2040 False False 0 0 2.15187999193565 0 0 0.000631133876986172 0.99962726552672 0.99926569731444 0.999839066414514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 0 8 2720 9631 0 0 0.00135528645033659 0.999170038385724 0.99836530325407 0.99964161554927 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 2.07582396316403 0.213319169078315 62.5 1102 False False 0 0 0 0 0 0 0 0 0 2.07582396316403 0 0 0.00135528645033659 0.999170038385724 0.99836530325407 0.99964161554927 3 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ser576Thr gyrB_p.Ser576Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Ser629Ala gyrB_p.Ser629Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Ser661Thr gyrB_p.Ser661Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 14 102 5829 21361 0.00239602943693308 0.0013105314105045 0.00401686566193227 0.995247635465685 0.994233888737989 0.996123402606858 0.120689655172413 0.0675787511491907 0.194200472849834 0.333333333333333 0.00840375865961264 0.905700675949754 0.00970873786407766 0.000245773753693975 0.0529082867402035 1.8323039972551 0.031052156200346 35.1480740732897 0.515155719153249 199 2040 False False 0.502985411011205 0.265424520047563 0.884028391935879 0.000171526586620926 4.34266775486036e-06 0.000955310352727744 0.995247635465685 0.994233888737989 0.996123402606858 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 7 3 2713 9636 0.0025735294117647 0.0010352988504908 0.00529522151968195 0.999688764394646 0.999090709558603 0.999935811136198 0.7 0.347547149940002 0.933260488822265 1 0.025 1 0.25 0.00630946320970987 0.805879550316756 Inf 0.0910378343925876 Inf 0.219757085020242 68 1102 False False 0 0 0 0 0 0 0 8.28750460744563 1.89007708426738 49.7180602938531 0.000368459837877671 9.32855191409846e-06 0.00205119861131408 0.999688764394646 0.999090709558603 0.999935811136198 82 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Thr167Ala gyrB_p.Thr167Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Thr167Met gyrB_p.Thr167Met 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1526 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Thr170Ala gyrB_p.Thr170Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1530 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 832 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Thr182Ile gyrB_p.Thr182Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1549 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Thr183Met gyrB_p.Thr183Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Thr189Pro gyrB_p.Thr189Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Thr209Ala gyrB_p.Thr209Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Thr250Ser gyrB_p.Thr250Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Thr267Ser gyrB_p.Thr267Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.56487735727821 0.58431003819195 215.5 2040 False False 0 0 5.56487735727821 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 5 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Thr371Ile gyrB_p.Thr371Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Thr373Ala gyrB_p.Thr373Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1578 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 860 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Thr378Ser gyrB_p.Thr378Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 1 5 5842 21458 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.9997670409542 0.99945643574724 0.999924354643808 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.00943637980382 0.591567772689754 255 2040 False False 0.73461143444026 0.0155328045999449 6.56618384712436 0 0 0.00063124187675269 0.9997670409542 0.99945643574724 0.999924354643808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 2 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Thr37Ser gyrB_p.Thr37Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Thr393Ser gyrB_p.Thr393Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 10 5843 21453 0 0 0.000631133876986172 0.9995340819084 0.999143327515781 0.999776552276323 0 0 0.30849710781876 NA NA NA 0 0 0.30849710781876 NA NA NA NA 1553 2040 False False 0 0 1.63855069807244 0 0 0.000631133876986172 0.9995340819084 0.999143327515781 0.999776552276323 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 2720 9635 0 0 0.00135528645033659 0.999585019192862 0.998937828281888 0.999886920491758 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 846 1102 False False 0 0 0 0 0 0 0 0 0 5.36894442066688 0 0 0.00135528645033659 0.999585019192862 0.998937828281888 0.999886920491758 4 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Thr500Ala gyrB_p.Thr500Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 2 3 10 6 5833 21457 0.00171144959780934 0.000821002097712802 0.00314515714291787 0.99972044914504 0.999391635540124 0.999897403075094 0.625 0.354346094302078 0.848016324918877 0.4 0.0527449505263169 0.853367200365326 0.25 0.0318540262499442 0.650855794412824 2.45236870678324 0.204771561914932 21.4124168534393 0.291144731489136 140 2040 False False 6.13092176695811 2.01776450876865 20.5308481503492 0.000342759211653813 4.15124264500694e-05 0.00123760991958594 0.99972044914504 0.999391635540124 0.999897403075094 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 6 3 2714 9636 0.00220588235294117 0.000809936709089192 0.00479504888600855 0.999688764394646 0.999090709558603 0.999935811136198 0.666666666666666 0.29929505620854 0.925145368580308 0.333333333333333 0.00840375865961264 0.905700675949754 0.25 0.00630946320970987 0.805879550316756 1.77523949889462 0.030079219633865 34.1166923765947 0.525087362755208 106 1102 False False 0 0 0 0 0 0 0 7.10095799557848 1.5151013065421 43.920065820381 0.000368324125230202 9.32511599939531e-06 0.00205044374137956 0.999688764394646 0.999090709558603 0.999935811136198 15 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Thr500Asn gyrB_p.Thr500Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 18 6 12 19 13 5824 21450 0.00325175423583775 0.00195886894634834 0.00507337943019098 0.99939430648092 0.998964468353895 0.999677455549724 0.59375 0.406449246576476 0.763015899448256 0.333333333333333 0.133427402506123 0.590074761827925 0.31578947368421 0.125760635872983 0.56550156884615 1.84151785714285 0.56681233294899 5.30389945939851 0.246242484791702 139 2040 False False 5.38289835164835 2.52013707522428 11.8622547199888 0.00102915951972555 0.000377774078470807 0.00223869101104451 0.99939430648092 0.998964468353895 0.999677455549724 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 2 5 11 5 2709 9634 0.00404411764705882 0.00202048490520436 0.0072244966118925 0.999481273991078 0.998789885214303 0.999831550309162 0.6875 0.413379363548641 0.889830045282882 0.285714285714285 0.0366925661760855 0.709579136262657 0.285714285714285 0.0366925661760855 0.709579136262657 1.42251753414544 0.135358515191127 8.69469314184121 0.652613150509244 141 1102 False False 0 0 0 0 0 0 0 7.82384643779992 2.50283709887196 28.7560343158813 0.000737735153080044 8.93556397173191e-05 0.00266238629472738 0.999481273991078 0.998789885214303 0.999831550309162 10 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Thr500Ile gyrB_p.Thr500Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 5841 21462 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99995340819084 0.99974043469953 0.999998820398217 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 142.989195698265 1 319.5 2040 False False 7.3487416538264 0.382468755528661 432.333734199629 0 0 0.000631349913487419 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Thr500Pro gyrB_p.Thr500Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 1 5840 21462 0.000513434879342803 0.000105895133877182 0.00149973424244328 0.99995340819084 0.99974043469953 0.999998820398217 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 143.013625436925 1 883 2040 False False 11.025 0.884946155157416 576.804300084131 0 0 0.000631457987209345 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Thr507Ala gyrB_p.Thr507Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1579 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 861 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Thr664Ile gyrB_p.Thr664Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 2 2 2 2 5841 21461 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99990681638168 0.999663429698698 0.999988714832292 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 3.67419962335216 0.266252080252227 50.6812073544246 0.2026265459619 89 2040 False False 3.67419962335216 0.266252080252227 50.6812073544246 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Tyr144Phe gyrB_p.Tyr144Phe 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1574 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Tyr144Ser gyrB_p.Tyr144Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Tyr253Ser gyrB_p.Tyr253Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Tyr456His gyrB_p.Tyr456His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 5841 21463 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 1 0.999828143201531 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1565 2040 False False Inf 0.689929368506768 Inf 0 0 0.000631349913487419 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 2718 9639 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 1 0.999617369678334 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 853 1102 False False 0 0 0 0 0 0 0 Inf 0.665658435310444 Inf 0 0 0.00135628304118183 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Tyr582His gyrB_p.Tyr582His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 1 5839 21462 0.000684579839123737 0.000186555462570677 0.00175186028923716 0.99995340819084 0.99974043469953 0.999998820398217 0.8 0.28358206388191 0.994949236620532 NA NA NA 0 0 0.975 NA NA NA NA 1560 2040 False False 14.7025175543757 1.45439517656642 721.12316039564 0 0 0.000631566097937464 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 4 1 2716 9638 0.00147058823529411 0.000400826576335422 0.00376097173045195 0.999896254798215 0.999422105789591 0.999997373402351 0.8 0.28358206388191 0.994949236620532 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0909561884679534 Inf 0.219910967219749 69 1102 False False 0 0 0 0 0 0 0 14.1944035346097 1.40353051471565 696.347745418072 0.000368052999631947 9.31825175754594e-06 0.0020489356671006 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Val218Ile gyrB_p.Val218Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Val222Met gyrB_p.Val222Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Val226Ala gyrB_p.Val226Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Val276Ala gyrB_p.Val276Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1524 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Val301Leu gyrB_p.Val301Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 15 235 5828 21228 0.00256717439671401 0.00143751780890291 0.00423063446053587 0.989050924847412 0.987567188885213 0.990399871277419 0.06 0.033966961656571 0.0970307808990985 NA NA NA 0 0 0.0155747979683157 NA NA NA NA NA NA False True 0.232494633391258 0.127957696296986 0.39182107089894 0 0 0.000632757763801925 0.989050924847412 0.987567188885213 0.990399871277419 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 11 90 2709 9549 0.00404411764705882 0.00202048490520436 0.0072244966118925 0.990662931839402 0.988535456022329 0.992485398657664 0.108910891089108 0.0556372238353029 0.186520095210926 NA NA NA 0 0 0.0401589196157746 NA NA NA NA NA NA False True 0 1 1 0 0 1 0 0.430823181985972 0.207403912930458 0.809765598085973 0 0 0.00136078589771868 0.990662931839402 0.988535456022329 0.992485398657664 318 Not assoc w R 5) Not assoc w R No change yes 1 +Levofloxacin gyrB p.Val301Met gyrB_p.Val301Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Val327Leu gyrB_p.Val327Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Val405Ala gyrB_p.Val405Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Val407Leu gyrB_p.Val407Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Val427Met gyrB_p.Val427Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 3 2 3 2 5840 21461 0.000513434879342803 0.000105895133877182 0.00149973424244328 0.99990681638168 0.999663429698698 0.999988714832292 0.6 0.146632799634673 0.947255049473683 0.6 0.146632799634673 0.947255049473683 0.6 0.146632799634673 0.947255049473683 5.51224315068493 0.63123591332421 66.0805594851213 0.0692044107584745 65 2040 False False 5.51224315068493 0.63123591332421 66.0805594851213 0.000513434879342803 0.000105895133877182 0.00149973424244328 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 3 2 3 2 2717 9637 0.00110294117647058 0.000227510766880298 0.0032198465640147 0.999792509596431 0.999250676427901 0.999974870961701 0.6 0.146632799634673 0.947255049473683 0.6 0.146632799634673 0.947255049473683 0.6 0.146632799634673 0.947255049473683 5.3203901361796 0.609038002991023 63.7727801541732 0.0744666604906942 41 1102 False False 0 0 0 0 0 0 0 5.3203901361796 0.609038002991023 63.7727801541732 0.00110294117647058 0.000227510766880298 0.0032198465640147 0.999792509596431 0.999250676427901 0.999974870961701 3 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Val457Leu gyrB_p.Val457Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 19 1 18 27 26 5816 21437 0.00462091391408523 0.00304735355609323 0.00671611737086474 0.998788612961841 0.998225537528248 0.999208533933273 0.50943396226415 0.368395393968202 0.64938156028936 0.0526315789473684 0.00133162880417942 0.260280654195214 0.037037037037037 0.000937257091944708 0.189705617413044 0.204770365275867 0.00491755925319803 1.29750583978814 0.0977933881968696 74 2040 False False 3.82763067400275 2.147895535661 6.83200293844731 0.000171909919202337 4.35237285335737e-06 0.000957444469066271 0.998788612961841 0.998225537528248 0.999208533933273 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 13 0 13 12 17 2708 9622 0.00441176470588235 0.00228163789982352 0.00769377081358202 0.998236331569664 0.997177692889563 0.998972273001006 0.413793103448275 0.235240209752898 0.610637208603093 0 0 0.24705263800047 0 0 0.195064322969093 0 0 1.16675330079639 0.0854496663159058 44 1102 False False 0 0 0 0 0 0 0 2.50812407680945 1.09140999702614 5.58004963597677 0 0 0.00136128806140643 0.998236331569664 0.997177692889563 0.998972273001006 32 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Val496Gly gyrB_p.Val496Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Val502Phe gyrB_p.Val502Phe 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0941866911272879 Inf 0.213982274957884 105.5 2040 False False Inf 0.0941866911272879 Inf 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0908652957857324 Inf 0.220082530949106 80 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Val535Ile gyrB_p.Val535Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Val561Gly gyrB_p.Val561Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1561 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Val630Ile gyrB_p.Val630Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 5843 21457 0 0 0.000631133876986172 0.99972044914504 0.999391635540124 0.999897403075094 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.1200699364824 0.35257212959262 148.5 2040 False False 0 0 3.1200699364824 0 0 0.000631133876986172 0.99972044914504 0.999391635540124 0.999897403075094 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 14 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Val670Ile gyrB_p.Val670Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Val670Phe gyrB_p.Val670Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 7 5 5836 21458 0.00119801471846654 0.000481795418920789 0.00246680058103687 0.9997670409542 0.99945643574724 0.999924354643808 0.583333333333333 0.276669685682105 0.848347770191569 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.01355931233799 0.591538639078009 250 2040 False False 5.14756682659355 1.40568884897439 20.5740799097861 0 0 0.000631890652349158 0.9997670409542 0.99945643574724 0.999924354643808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 2719 9637 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999792509596431 0.999250676427901 0.999974870961701 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8778635755656 1 457.5 1102 False False 0 0 0 0 0 0 0 1.77215888194189 0.0300270423699391 34.0580978516331 0 0 0.0013557845626193 0.999792509596431 0.999250676427901 0.999974870961701 2 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Val675Ile gyrB_p.Val675Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1535 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin gyrB p.Val68Ala gyrB_p.Val68Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Val68Leu gyrB_p.Val68Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin gyrB p.Val75Gly gyrB_p.Val75Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Levofloxacin Rv1129c c.1014C>T Rv1129c_c.1014C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.1026C>T Rv1129c_c.1026C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.1050C>T Rv1129c_c.1050C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.89146792489366 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.57852451631077 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.106C>T Rv1129c_c.106C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.1093C>T Rv1129c_c.1093C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.-10T>C Rv1129c_c.-10T>C 2 upstream_gene_variant 1254544 NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1892 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c c.1125A>C Rv1129c_c.1125A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 15 5842 21448 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.9993011228626 0.9988475700008 0.999608792686571 0.0625 0.00158111172276588 0.302320738434531 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.244756361976492 0.00581660393244517 1.59156192805458 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 NA NA NA NA NA NA 19 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.1140C>T Rv1129c_c.1140C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.1167G>A Rv1129c_c.1167G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.89146792489366 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.117C>T Rv1129c_c.117C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.-11A>C Rv1129c_c.-11A>C 2 upstream_gene_variant 1254545 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c c.1212G>T Rv1129c_c.1212G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.1215T>C Rv1129c_c.1215T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.1216C>T Rv1129c_c.1216C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.1221C>T Rv1129c_c.1221C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.1224G>A Rv1129c_c.1224G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.1242C>T Rv1129c_c.1242C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.1263G>A Rv1129c_c.1263G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.1269C>A Rv1129c_c.1269C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.1299C>G Rv1129c_c.1299C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.-12A>C Rv1129c_c.-12A>C 2 upstream_gene_variant 1254546 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c c.-12A>T Rv1129c_c.-12A>T 2 upstream_gene_variant 1254546 0 0 0 0 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1948 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0 0 0.00063124187675269 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c c.1317G>C Rv1129c_c.1317G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.1317G>T Rv1129c_c.1317G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 7 5843 21456 0 0 0.000631133876986172 0.99967385733588 0.999328137654343 0.999868864001311 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.5485399472607 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.132A>G Rv1129c_c.132A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.135C>T Rv1129c_c.135C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.1362G>A Rv1129c_c.1362G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.1389C>T Rv1129c_c.1389C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.67374186922286 0.0467931454016956 287.712465214691 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.-13A>G Rv1129c_c.-13A>G 2 upstream_gene_variant 1254547 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c c.1404G>A Rv1129c_c.1404G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 3 5842 21460 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99986022457252 0.999591571764338 0.999971174018896 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.22446650690402 0.0233203404016305 15.2512395040111 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 2719 9637 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999792509596431 0.999250676427901 0.999974870961701 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.77215888194189 0.0300270423699391 34.0580978516331 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.-15G>A Rv1129c_c.-15G>A 2 upstream_gene_variant 1254549 1 12 0 12 0 25 5843 21438 0 0 0.000631133876986172 0.998835204771001 0.998281009378759 0.999246068539694 0 0 0.137185171530712 0 0 0.264648469397051 0 0 0.137185171530712 0 0 1.32093558373401 0.0822623236383813 66 2040 False False 0 0 0.583611266727936 0 0 0.000631133876986172 0.998835204771001 0.998281009378759 0.999246068539694 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 12 2720 9627 0 0 0.00135528645033659 0.998755057578587 0.997826347023296 0.999356559855396 0 0 0.264648469397051 0 0 0.841886116991581 0 0 0.264648469397051 0 0 18.8513478323466 1 147 1102 False False 0 0 0 0 0 0 0 0 0 1.2747953585009 0 0 0.00135528645033659 0.998755057578587 0.997826347023296 0.999356559855396 35 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c c.15T>C Rv1129c_c.15T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.-17T>G Rv1129c_c.-17T>G 2 upstream_gene_variant 1254551 1 4 0 4 1 6 5842 21457 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99972044914504 0.999391635540124 0.999897403075094 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.602364635616474 0 0 0.4592581264399 0 0 5.56531138221033 0.584314704024368 230 2040 False False 0.612147666324318 0.0133096260827154 5.04744841661085 0 0 0.00063124187675269 0.99972044914504 0.999391635540124 0.999897403075094 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c c.183G>T Rv1129c_c.183G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.186G>A Rv1129c_c.186G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.18C>T Rv1129c_c.18C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.-18T>G Rv1129c_c.-18T>G 2 upstream_gene_variant 1254552 NA 0 0 0 3 0 5840 21463 0.000513434879342803 0.000105895133877182 0.00149973424244328 1 0.999828143201531 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1898 2040 False False Inf 1.51820267072123 Inf 0 0 0.000631457987209345 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c c.195T>G Rv1129c_c.195T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.-19T>C Rv1129c_c.-19T>C 2 upstream_gene_variant 1254553 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c c.-1C>T Rv1129c_c.-1C>T 2 upstream_gene_variant 1254535 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 9 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c c.211C>T Rv1129c_c.211C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.89146792489366 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 18.8709233025667 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.21A>G Rv1129c_c.21A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.-21C>G Rv1129c_c.-21C>G 2 upstream_gene_variant 1254555 1 3 0 3 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89146792489366 1 319.5 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c c.-21C>T Rv1129c_c.-21C>T 2 upstream_gene_variant 1254555 1 3 0 3 1 3 5842 21460 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99986022457252 0.999591571764338 0.999971174018896 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89298982087011 1 883 2040 False False 1.22446650690402 0.0233203404016305 15.2512395040111 0 0 0.00063124187675269 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c c.-22A>G Rv1129c_c.-22A>G 2 upstream_gene_variant 1254556 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1893 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c c.-23C>A Rv1129c_c.-23C>A 2 upstream_gene_variant 1254557 1 19 0 19 2 19 5841 21444 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.999114755625961 0.998617924918733 0.999466943572351 0.0952380952380952 0.0117493178844458 0.303774406913924 0 0 0.176466911806965 0 0 0.176466911806965 0 0 0.786994111345036 0.020787268813959 44 2040 False False 0.386451490822588 0.043638942763826 1.60263214194662 0 0 0.000631349913487419 0.999114755625961 0.998617924918733 0.999466943572351 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 2 9 2718 9630 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 0.99906629318394 0.998228276906464 0.999572963722204 0.181818181818181 0.0228311982999596 0.517755852360172 0 0 0.336267116879942 0 0 0.336267116879942 0 0 1.79624893175337 0.221049733118256 89 1102 False False 0 0 0 0 0 0 0 0.787343635025754 0.0827356806508646 3.80697946362256 0 0 0.00135628304118183 0.99906629318394 0.998228276906464 0.999572963722204 22 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c c.-23C>T Rv1129c_c.-23C>T 2 upstream_gene_variant 1254557 1 3 0 3 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89146792489366 1 319.5 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.57852451631077 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 8.57852451631077 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 4 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c c.246A>G Rv1129c_c.246A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.249G>A Rv1129c_c.249G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.24G>T Rv1129c_c.24G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.-25G>A Rv1129c_c.-25G>A 2 upstream_gene_variant 1254559 NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1934 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c c.264G>C Rv1129c_c.264G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.-26C>T Rv1129c_c.-26C>T 2 upstream_gene_variant 1254560 1 3 0 3 5 3 5838 21460 0.000855724798904672 0.00027790803803495 0.00199583691247191 0.99986022457252 0.999591571764338 0.999971174018896 0.625 0.244863216366551 0.914766585862746 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89908261456576 1 319.5 2040 False False 6.12652734954893 1.19146359990854 39.4644754416156 0 0 0.000631674245690789 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 2 3 2718 9636 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 0.999688764394646 0.999090709558603 0.999935811136198 0.4 0.0527449505263169 0.853367200365326 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.58483775120996 1 147 1102 False False 0 0 0 0 0 0 0 2.3635025754231 0.197291785205426 20.6413600392426 0 0 0.00135628304118183 0.999688764394646 0.999090709558603 0.999935811136198 6 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c c.-27C>T Rv1129c_c.-27C>T 2 upstream_gene_variant 1254561 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1960 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c c.282C>T Rv1129c_c.282C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.-28delTinsCC Rv1129c_c.-28delTinsCC 2 upstream_gene_variant 1254562 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1928 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c c.-28T>C Rv1129c_c.-28T>C 2 upstream_gene_variant 1254562 NA 0 0 0 4176 10904 1667 10559 0.714701352045182 0.702932331815582 0.726255644244631 0.491962912919908 0.485252770230615 0.498675233083114 0.276923076923076 0.269791507715532 0.284140794576369 NA NA NA 0 0 0.000338247940296992 NA NA NA NA 1915 2040 False True 2.42583823660799 2.27721203634203 2.58459445024366 0 0 0.00221043847025932 0.491962912919908 0.485252770230615 0.498675233083114 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 1831 4932 889 4707 0.673161764705882 0.655171248487565 0.690778890546726 0.488328664799253 0.478302663605143 0.49836172227552 0.270737838237468 0.260174593172387 0.281499083411095 NA NA NA 0 0 0.000747668340027961 NA NA NA NA 1043 1102 False True 0 1 1 0 0 0 0 1.9656568932533 1.7956886183831 2.15243286243601 0 0 0.00414087354381631 0.488328664799253 0.478302663605143 0.49836172227552 12447 5) Not assoc w R New NotAwR yes 5 +Levofloxacin Rv1129c c.294G>A Rv1129c_c.294G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.-29A>G Rv1129c_c.-29A>G 2 upstream_gene_variant 1254563 1 2 0 2 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 19.5666713375759 1 883 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 65 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c c.-2A>G Rv1129c_c.-2A>G 2 upstream_gene_variant 1254536 1 3 0 3 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89146792489366 1 319.5 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.57852451631077 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 8.57852451631077 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c c.303C>T Rv1129c_c.303C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.309C>T Rv1129c_c.309C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.-31T>C Rv1129c_c.-31T>C 2 upstream_gene_variant 1254565 1 6 0 6 0 6 5843 21457 0 0 0.000631133876986172 0.99972044914504 0.999391635540124 0.999897403075094 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.1200699364824 0.35257212959262 148.5 2040 False False 0 0 3.1200699364824 0 0 0.000631133876986172 0.99972044914504 0.999391635540124 0.999897403075094 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c c.-31T>G Rv1129c_c.-31T>G 2 upstream_gene_variant 1254565 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c c.334C>A Rv1129c_c.334C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.336G>C Rv1129c_c.336G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.345G>A Rv1129c_c.345G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.-36T>C Rv1129c_c.-36T>C 2 upstream_gene_variant 1254570 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c c.375C>T Rv1129c_c.375C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.-37G>A Rv1129c_c.-37G>A 2 upstream_gene_variant 1254571 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1953 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c c.-38T>C Rv1129c_c.-38T>C 2 upstream_gene_variant 1254572 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1876 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c c.39T>C Rv1129c_c.39T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 5840 21463 0.000513434879342803 0.000105895133877182 0.00149973424244328 1 0.999828143201531 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.51820267072123 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 2718 9639 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 1 0.999617369678334 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.665658435310444 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.3G>A Rv1129c_c.3G>A 2 initiator_codon_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 5843 21458 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.0087500478358 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 13 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.-40T>G Rv1129c_c.-40T>G 2 upstream_gene_variant 1254574 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c c.411C>T Rv1129c_c.411C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 18.8709233025667 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.-41T>C Rv1129c_c.-41T>C 2 upstream_gene_variant 1254575 1 3 0 3 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89146792489366 1 319.5 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c c.-42C>A Rv1129c_c.-42C>A 2 upstream_gene_variant 1254576 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c c.-42C>T Rv1129c_c.-42C>T 2 upstream_gene_variant 1254576 1 5 0 5 0 6 5843 21457 0 0 0.000631133876986172 0.99972044914504 0.999391635540124 0.999897403075094 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 4.00856324322819 0.591573991022433 278.5 2040 False False 0 0 3.1200699364824 0 0 0.000631133876986172 0.99972044914504 0.999391635540124 0.999897403075094 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.57852451631077 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 8.57852451631077 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 5 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c c.-42delC Rv1129c_c.-42delC 2 upstream_gene_variant 1254575 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c c.435C>T Rv1129c_c.435C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.89146792489366 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.57852451631077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.-43A>G Rv1129c_c.-43A>G 2 upstream_gene_variant 1254577 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c c.-43A>T Rv1129c_c.-43A>T 2 upstream_gene_variant 1254577 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c c.-44T>C Rv1129c_c.-44T>C 2 upstream_gene_variant 1254578 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1957 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c c.-46C>G Rv1129c_c.-46C>G 2 upstream_gene_variant 1254580 1 21 0 21 14 31 5829 21432 0.00239602943693308 0.0013105314105045 0.00401686566193227 0.998555653916041 0.997950487085694 0.999018432490374 0.311111111111111 0.181658803933722 0.466491029912115 0 0 0.161097615219079 0 0 0.11218874692237 0 0 0.706343056599688 0.0130845850401358 39 2040 False False 1.66048511613235 0.815603652843705 3.21742324157623 0 0 0.000632649244748106 0.998555653916041 0.997950487085694 0.999018432490374 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 3 12 2717 9627 0.00110294117647058 0.000227510766880298 0.0032198465640147 0.998755057578587 0.997826347023296 0.999356559855396 0.2 0.0433120051058366 0.480891133806853 0 0 0.336267116879942 0 0 0.264648469397051 0 0 1.79635059238863 0.221046609110563 88 1102 False False 0 0 0 0 0 0 0 0.885811556864188 0.160287560381105 3.28561891629784 0 0 0.00135678188642832 0.998755057578587 0.997826347023296 0.999356559855396 51 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c c.-46C>T Rv1129c_c.-46C>T 2 upstream_gene_variant 1254580 1 2 0 2 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 19.5666713375759 1 883 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 8 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c c.474C>T Rv1129c_c.474C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.477C>T Rv1129c_c.477C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.-47G>A Rv1129c_c.-47G>A 2 upstream_gene_variant 1254581 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c c.480C>T Rv1129c_c.480C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 15 5843 21448 0 0 0.000631133876986172 0.9993011228626 0.9988475700008 0.999608792686571 0 0 0.218019360910534 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.02381522685458 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 5 2720 9634 0 0 0.00135528645033659 0.999481273991078 0.998789885214303 0.999831550309162 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.8675231049739 NA NA NA NA NA NA 14 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.-48A>C Rv1129c_c.-48A>C 2 upstream_gene_variant 1254582 NA 0 0 0 13 171 5830 21292 0.00222488447715214 0.00118517251163732 0.00380161509892997 0.992032800633648 0.990751048019315 0.993178450501191 0.0706521739130434 0.0381533235504087 0.117787142357554 NA NA NA 0 0 0.0213413745665028 NA NA NA NA 1911 2040 False True 0.277648380528221 0.144740654894223 0.48811530269547 0 0 0.000632540762910314 0.992032800633648 0.990751048019315 0.993178450501191 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 12 126 2708 9513 0.00441176470588235 0.00228163789982352 0.00769377081358202 0.986928104575163 0.984455680301928 0.989099397065986 0.0869565217391304 0.0457411121497283 0.146969067452897 NA NA NA 0 0 0.0288524068567209 NA NA NA NA 1039 1102 False True 0 1 1 0 0 0 0 0.334564254062038 0.168136896419529 0.606444571757038 0 0 0.00136128806140643 0.986928104575163 0.984455680301928 0.989099397065986 254 5) Not assoc w R New NotAwR yes 5 +Levofloxacin Rv1129c c.-48A>G Rv1129c_c.-48A>G 2 upstream_gene_variant 1254582 1 52 4 48 19 80 5824 21383 0.00325175423583775 0.00195886894634834 0.00507337943019098 0.996272655267204 0.995363112689741 0.9970433744664 0.191919191919191 0.119684354393664 0.283367629217074 0.0769230769230769 0.0213565864913836 0.185396604383411 0.0476190476190476 0.0131250722704972 0.117456971371829 0.305960966117216 0.0801063609499542 0.836148345770075 0.0162811005178747 40 2040 False False 0.871988753434065 0.498764576297643 1.45323931322872 0.000686341798215511 0.000187035694331358 0.00175636678051708 0.996272655267204 0.995363112689741 0.9970433744664 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 25 2 23 6 37 2714 9602 0.00220588235294117 0.000809936709089192 0.00479504888600855 0.996161427533976 0.994712877434656 0.997295894108395 0.13953488372093 0.0529765738668172 0.279324800314149 0.08 0.00983959001879751 0.260305842105214 0.0512820512820512 0.00627197209569041 0.173244781373605 0.307647944634904 0.0351392207876696 1.24641809548315 0.142519070912196 55 1102 False False 0 0 0 0 0 0 0 0.573721842697524 0.197710706323791 1.37327198623042 0.000736377025036818 8.91911181595749e-05 0.00265748970872875 0.996161427533976 0.994712877434656 0.997295894108395 277 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c c.-48dupA Rv1129c_c.-48dupA 2 upstream_gene_variant 1254581 1 11 1 10 1 14 5842 21449 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99934771467176 0.998905818000026 0.999643345117175 0.0666666666666666 0.0016864302413527 0.319484566578303 0.0909090909090909 0.00229897221381426 0.412779916988382 0.0666666666666666 0.0016864302413527 0.319484566578303 0.367151660390277 0.00846225024541751 2.58168558108467 0.475941073724325 187 2040 False False 0.262251185993055 0.00620473568659099 1.72443749532806 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99934771467176 0.998905818000026 0.999643345117175 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 7 2720 9632 0 0 0.00135528645033659 0.999273783587509 0.99850429270085 0.999707975074577 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 3.00943555955456 0.350000935648685 91.5 1102 False False 0 0 0 0 0 0 0 0 0 2.45859411933764 0 0 0.00135528645033659 0.999273783587509 0.99850429270085 0.999707975074577 7 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c c.-49A>C Rv1129c_c.-49A>C 2 upstream_gene_variant 1254583 1 82 1 81 10 102 5833 21361 0.00171144959780934 0.000821002097712802 0.00314515714291787 0.995247635465685 0.994233888737989 0.996123402606858 0.0892857142857142 0.0436498374378033 0.158073804583199 0.0121951219512195 0.000308706096370227 0.0660827093893067 0.00970873786407766 0.000245773753693975 0.0529082867402035 0.0452110490969854 0.00113489717555263 0.25925253668637 9.64397415891372e-08 16 2040 True False 0.35902891929959 0.167040034796538 0.688167438342159 0.000171408981830647 4.3396902722879e-06 0.000954655614247342 0.995247635465685 0.994233888737989 0.996123402606858 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 53 1 52 6 65 2714 9574 0.00220588235294117 0.000809936709089192 0.00479504888600855 0.993256561884012 0.991412900017842 0.994791813676927 0.0845070422535211 0.0316460281334226 0.174916055821039 0.0188679245283018 0.000477580412422113 0.100701526769146 0.0151515151515151 0.000383529584995338 0.0815523210948241 0.0678391247661697 0.00168899151424871 0.395455959093814 4.21635569077692e-05 13 1102 True False 0 0 0 0 0 0 0 0.325627798877614 0.115167872748958 0.74904136362854 0.000368324125230202 9.32511599939531e-06 0.00205044374137956 0.993256561884012 0.991412900017842 0.994791813676927 227 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c c.-49A>G Rv1129c_c.-49A>G 2 upstream_gene_variant 1254583 1 3 1 2 1 2 5842 21461 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99990681638168 0.999663429698698 0.999988714832292 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 1.83678534748373 0.0311281139040964 35.2896458967866 0.514394017317937 195.5 2040 False False 1.83678534748373 0.0311281139040964 35.2896458967866 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 5 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c c.-4G>A Rv1129c_c.-4G>A 2 upstream_gene_variant 1254538 1 1 0 1 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 142.93371627475 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c c.-4G>T Rv1129c_c.-4G>T 2 upstream_gene_variant 1254538 1 1 0 1 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 142.964774304408 1 883 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0 0 0.00063124187675269 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1021 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 4 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c c.57T>C Rv1129c_c.57T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.591G>C Rv1129c_c.591G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 12 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.597G>A Rv1129c_c.597G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.615G>A Rv1129c_c.615G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.627T>C Rv1129c_c.627T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.648C>G Rv1129c_c.648C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.89146792489366 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.57852451631077 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.651G>A Rv1129c_c.651G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.678C>T Rv1129c_c.678C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.67374186922286 0.0467931454016956 287.712465214691 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.682C>A Rv1129c_c.682C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.684G>C Rv1129c_c.684G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.6G>A Rv1129c_c.6G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.-6G>A Rv1129c_c.-6G>A 2 upstream_gene_variant 1254540 1 6 0 6 1 6 5842 21457 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99972044914504 0.999391635540124 0.999897403075094 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.12060460159324 0.352585548784684 159 2040 False False 0.612147666324318 0.0133096260827154 5.04744841661085 0 0 0.00063124187675269 0.99972044914504 0.999391635540124 0.999897403075094 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.57852451631077 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 8.57852451631077 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 19 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c c.70C>A Rv1129c_c.70C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 4 5842 21459 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99981363276336 0.999522895233871 0.999949218940757 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.918307086614173 0.0186435710006194 9.27999188457764 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.736C>T Rv1129c_c.736C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 5842 21461 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99990681638168 0.999663429698698 0.999988714832292 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.83678534748373 0.0311281139040964 35.2896458967866 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.741G>C Rv1129c_c.741G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.742C>T Rv1129c_c.742C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.753G>A Rv1129c_c.753G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.756A>C Rv1129c_c.756A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.7C>A Rv1129c_c.7C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.816C>T Rv1129c_c.816C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.864C>A Rv1129c_c.864C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.89146792489366 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 18.8709233025667 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.-8T>C Rv1129c_c.-8T>C 2 upstream_gene_variant 1254542 NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1903 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1034 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c c.-8T>G Rv1129c_c.-8T>G 2 upstream_gene_variant 1254542 1 2 0 2 1 4 5842 21459 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99981363276336 0.999522895233871 0.999949218940757 0.2 0.00505076337946806 0.716417936118089 0 0 0.841886116991581 0 0 0.602364635616474 0 0 19.5691016337055 1 883 2040 False False 0.918307086614173 0.0186435710006194 9.27999188457764 0 0 0.00063124187675269 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 2719 9637 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999792509596431 0.999250676427901 0.999974870961701 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 137.946920474639 1 457.5 1102 False False 0 0 0 0 0 0 0 1.77215888194189 0.0300270423699391 34.0580978516331 0 0 0.0013557845626193 0.999792509596431 0.999250676427901 0.999974870961701 7 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c c.903T>C Rv1129c_c.903T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.915G>T Rv1129c_c.915G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 5843 21458 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.0087500478358 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 18.8709233025667 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.927G>A Rv1129c_c.927G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.936G>A Rv1129c_c.936G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.969A>G Rv1129c_c.969A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 10 60 5833 21403 0.00171144959780934 0.000821002097712802 0.00314515714291787 0.997204491450403 0.996403071450442 0.997866075190238 0.142857142857142 0.0706904542668698 0.247068247750352 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.61154923138465 0.27894176993137 1.20504233841154 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 7 2718 9632 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 0.999273783587509 0.99850429270085 0.999707975074577 0.222222222222222 0.0281449734778982 0.600093573716312 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.01250919793966 0.102561093914037 5.32146609270942 NA NA NA NA NA NA 49 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.978C>T Rv1129c_c.978C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.987G>A Rv1129c_c.987G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.996A>C Rv1129c_c.996A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.9G>T Rv1129c_c.9G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 7 5843 21456 0 0 0.000631133876986172 0.99967385733588 0.999328137654343 0.999868864001311 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.5485399472607 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 14 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv1129c c.-9T>G Rv1129c_c.-9T>G 2 upstream_gene_variant 1254543 1 47 2 45 11 231 5832 21232 0.00188259455759027 0.000940147291275547 0.00336597924963922 0.989237292084051 0.987765278216737 0.990574440580968 0.0454545454545454 0.0229060404235868 0.079873803082213 0.0425531914893617 0.00519558317674383 0.145405245488214 0.00858369098712446 0.00104122049466815 0.0306615362840202 0.161804602956866 0.0190180164371592 0.619777879532497 0.00202485392515758 28 2040 False False 0.173362074596642 0.0852869899909215 0.31633511665354 0.000342817963661295 4.15195425150354e-05 0.0012378219620514 0.989237292084051 0.987765278216737 0.990574440580968 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 2 7 7 16 2713 9623 0.0025735294117647 0.0010352988504908 0.00529522151968195 0.998340076771449 0.997305784636461 0.999050922126668 0.304347826086956 0.132102879698099 0.529191666008506 0.222222222222222 0.0281449734778982 0.600093573716312 0.111111111111111 0.0137512156643644 0.347120438608672 1.01342741298509 0.102653937643048 5.32629292289402 1 457.5 1102 False False 0 0 0 0 0 0 0 1.55181072613343 0.539296719978509 3.99163532455144 0.000736648250460405 8.92239739865477e-05 0.00265846758449282 0.998340076771449 0.997305784636461 0.999050922126668 612 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c LoF Rv1129c_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 6 0 6 3 8 5840 21455 0.000513434879342803 0.000105895133877182 0.00149973424244328 0.99962726552672 0.99926569731444 0.999839066414514 0.272727272727272 0.0602177341729066 0.609742559572421 0 0 0.4592581264399 0 0 0.369416647552819 0 0 3.12138327783248 0.352605108119594 161.5 2040 False False 1.37767551369863 0.235322166271864 5.74292468396216 0 0 0.000631457987209345 0.99962726552672 0.99926569731444 0.999839066414514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 2719 9637 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999792509596431 0.999250676427901 0.999974870961701 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8778635755656 1 457.5 1102 False False 0 0 0 0 0 0 0 1.77215888194189 0.0300270423699391 34.0580978516331 0 0 0.0013557845626193 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Ala104Thr Rv1129c_p.Ala104Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0941823027901977 Inf 0.213990111701153 120.5 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Ala111Gly Rv1129c_p.Ala111Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1935 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Ala129Pro Rv1129c_p.Ala129Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Ala130Pro Rv1129c_p.Ala130Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 2 2 5841 21461 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99990681638168 0.999663429698698 0.999988714832292 0.5 0.067585986488543 0.932414013511457 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5742605605944 1 883 2040 False False 3.67419962335216 0.266252080252227 50.6812073544246 0 0 0.000631349913487419 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 2718 9638 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 0.999896254798215 0.999422105789591 0.999997373402351 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 138.011851332821 1 457.5 1102 False False 0 0 0 0 0 0 0 7.09197939661515 0.368993183584618 417.296682266591 0 0 0.00135628304118183 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Ala130Val Rv1129c_p.Ala130Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Ala141Thr Rv1129c_p.Ala141Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5841 21463 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 1 0.999828143201531 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1954 2040 False False Inf 0.689929368506768 Inf 0 0 0.000631349913487419 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Ala150Thr Rv1129c_p.Ala150Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Ala150Val Rv1129c_p.Ala150Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Ala195Pro Rv1129c_p.Ala195Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 5 3 5838 21460 0.000855724798904672 0.00027790803803495 0.00199583691247191 0.99986022457252 0.999591571764338 0.999971174018896 0.625 0.244863216366551 0.914766585862746 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1912 2040 False False 6.12652734954893 1.19146359990854 39.4644754416156 0 0 0.000631674245690789 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1040 1102 False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 0 0 0.0013557845626193 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Ala195Ser Rv1129c_p.Ala195Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Ala216Pro Rv1129c_p.Ala216Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1894 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Ala230Ser Rv1129c_p.Ala230Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1901 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1032 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Ala230Thr Rv1129c_p.Ala230Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 1 5 5842 21458 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.9997670409542 0.99945643574724 0.999924354643808 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.602364635616474 0 0 0.521823750104981 0 0 5.56557073483698 0.584317496465312 233.5 2040 False False 0.73461143444026 0.0155328045999449 6.56618384712436 0 0 0.00063124187675269 0.9997670409542 0.99945643574724 0.999924354643808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Ala239Thr Rv1129c_p.Ala239Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1902 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1033 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Ala239Val Rv1129c_p.Ala239Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 142.93371627475 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Ala296Gly Rv1129c_p.Ala296Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Ala342Ser Rv1129c_p.Ala342Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1906 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1036 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Ala351Val Rv1129c_p.Ala351Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 2 2 5841 21461 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99990681638168 0.999663429698698 0.999988714832292 0.5 0.067585986488543 0.932414013511457 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5742605605944 1 883 2040 False False 3.67419962335216 0.266252080252227 50.6812073544246 0 0 0.000631349913487419 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 137.961202437293 1 457.5 1102 False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 0 0 0.0013557845626193 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Ala353Gly Rv1129c_p.Ala353Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1919 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Ala373Thr Rv1129c_p.Ala373Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.56487735727821 0.58431003819195 215.5 2040 False False 0 0 5.56487735727821 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Ala383Glu Rv1129c_p.Ala383Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 2 3 5841 21460 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99986022457252 0.999591571764338 0.999971174018896 0.4 0.0527449505263169 0.853367200365326 0 0 0.841886116991581 0 0 0.707598226178713 0 0 19.5733512949936 1 883 2040 False False 2.44935227986075 0.204519727205419 21.3860749684357 0 0 0.000631349913487419 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 1 2718 9638 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 0.999896254798215 0.999422105789591 0.999997373402351 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 1038 1102 False False 0 0 0 0 0 0 0 7.09197939661515 0.368993183584618 417.296682266591 0 0 0.00135628304118183 0.999896254798215 0.999422105789591 0.999997373402351 4 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Ala383Thr Rv1129c_p.Ala383Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Ala400Thr Rv1129c_p.Ala400Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 9 5841 21454 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99958067371756 0.999204138016772 0.999808239967157 0.181818181818181 0.0228311982999596 0.517755852360172 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1941 2040 False False 0.816222488538872 0.0857956692845824 3.94510286595224 0 0 0.000631349913487419 0.99958067371756 0.999204138016772 0.999808239967157 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 27 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Ala445Pro Rv1129c_p.Ala445Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Ala445Thr Rv1129c_p.Ala445Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Ala456Val Rv1129c_p.Ala456Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Ala468Thr Rv1129c_p.Ala468Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 142.93371627475 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Ala73Thr Rv1129c_p.Ala73Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 8.89105370607792 1 883 2040 False False 0 0 5.56487735727821 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 137.896313968788 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Ala82Thr Rv1129c_p.Ala82Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Arg112Trp Rv1129c_p.Arg112Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Arg126Trp Rv1129c_p.Arg126Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 1 9 5842 21454 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99958067371756 0.999204138016772 0.999808239967157 0.1 0.00252857854446178 0.445016117028195 0 0 0.4592581264399 0 0 0.336267116879942 0 0 3.12016794372308 0.35257458021928 153 2040 False False 0.408041386131081 0.00931136520654082 2.94575545214231 0 0 0.00063124187675269 0.99958067371756 0.999204138016772 0.999808239967157 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 4 2719 9635 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999585019192862 0.998937828281888 0.999886920491758 0.2 0.00505076337946806 0.716417936118089 0 0 0.841886116991581 0 0 0.602364635616474 0 0 18.8739470370686 1 457.5 1102 False False 0 0 0 0 0 0 0 0.885895549834498 0.0179820541723419 8.95537117058933 0 0 0.0013557845626193 0.999585019192862 0.998937828281888 0.999886920491758 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Arg151Gln Rv1129c_p.Arg151Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Arg165His Rv1129c_p.Arg165His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Arg201Gln Rv1129c_p.Arg201Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Arg228Trp Rv1129c_p.Arg228Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Arg238Cys Rv1129c_p.Arg238Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 0 8 5843 21455 0 0 0.000631133876986172 0.99962726552672 0.99926569731444 0.999839066414514 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 2.15187999193565 0.215644316894169 127.5 2040 False False 0 0 2.15187999193565 0 0 0.000631133876986172 0.99962726552672 0.99926569731444 0.999839066414514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 0 8 2720 9631 0 0 0.00135528645033659 0.999170038385724 0.99836530325407 0.99964161554927 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 2.07582396316403 0.213319169078315 62.5 1102 False False 0 0 0 0 0 0 0 0 0 2.07582396316403 0 0 0.00135528645033659 0.999170038385724 0.99836530325407 0.99964161554927 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Arg294Cys Rv1129c_p.Arg294Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 6 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Arg294Ser Rv1129c_p.Arg294Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Arg300Ser Rv1129c_p.Arg300Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Arg308Cys Rv1129c_p.Arg308Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1929 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Arg308His Rv1129c_p.Arg308His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1871 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Arg309Gln Rv1129c_p.Arg309Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Arg309Trp Rv1129c_p.Arg309Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 142.93371627475 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Arg330Leu Rv1129c_p.Arg330Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1943 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1060 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Arg358Trp Rv1129c_p.Arg358Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 1 4 1 4 5842 21459 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99981363276336 0.999522895233871 0.999949218940757 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 0.918307086614173 0.0186435710006194 9.27999188457764 1 319.5 2040 False False 0.918307086614173 0.0186435710006194 9.27999188457764 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.57852451631077 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 8.57852451631077 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Arg3fs Rv1129c_p.Arg3fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1895 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Arg3Gln Rv1129c_p.Arg3Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 5842 21461 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99990681638168 0.999663429698698 0.999988714832292 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5709198500876 1 883 2040 False False 1.83678534748373 0.0311281139040964 35.2896458967866 0 0 0.00063124187675269 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 4 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Arg3Pro Rv1129c_p.Arg3Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Asn166Asp Rv1129c_p.Asn166Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 9 0 9 15 15 5828 21448 0.00256717439671401 0.00143751780890291 0.00423063446053587 0.9993011228626 0.9988475700008 0.999608792686571 0.5 0.312970285868027 0.687029714131972 0 0 0.336267116879942 0 0 0.218019360910534 0 0 1.86511813949961 0.219622523981767 134 2040 False False 3.68016472203157 1.6753015551825 8.08238044695059 0 0 0.000632757763801925 0.9993011228626 0.9988475700008 0.999608792686571 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 10 7 2710 9632 0.00367647058823529 0.0017643752042604999 0.00675073416095428 0.999273783587509 0.99850429270085 0.999707975074577 0.588235294117647 0.329247153946757 0.815563038216053 0 0 0.602364635616474 0 0 0.409616397225003 0 0 5.38708543437498 0.582467365697916 127 1102 False False 0 0 0 0 0 0 0 5.07749077490774 1.74246558739195 15.7318710548197 0 0 0.00136028410437921 0.999273783587509 0.99850429270085 0.999707975074577 15 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Asn166Ser Rv1129c_p.Asn166Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1920 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1046 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Asn211Asp Rv1129c_p.Asn211Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1961 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1068 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 7 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Asn211Ser Rv1129c_p.Asn211Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Asn279Asp Rv1129c_p.Asn279Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Asn411Asp Rv1129c_p.Asn411Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Asn411Tyr Rv1129c_p.Asn411Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 4 18 5839 21445 0.000684579839123737 0.000186555462570677 0.00175186028923716 0.99916134743512 0.998674889990656 0.999502887997069 0.181818181818181 0.0518672993124368 0.402845783077871 0 0 0.975 0 0 0.185301968137852 0 0 142.925021698394 1 883 2040 False False 0.816159540256132 0.200840890793996 2.47904058462114 0 0 0.000631566097937464 0.99916134743512 0.998674889990656 0.999502887997069 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 14 2719 9625 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.998547567175018 0.997564264113055 0.999205721130751 0.0666666666666666 0.0016864302413527 0.319484566578303 0 0 0.975 0 0 0.231635761650116 0 0 137.775536424537 1 457.5 1102 False False 0 0 0 0 0 0 0 0.252850312614931 0.00598131614636588 1.66344483001603 0 0 0.0013557845626193 0.998547567175018 0.997564264113055 0.999205721130751 31 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Asn451Lys Rv1129c_p.Asn451Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Asn5fs Rv1129c_p.Asn5fs 2 frameshift (see "Genomic_coordinates" sheet) 1 4 0 4 0 6 5843 21457 0 0 0.000631133876986172 0.99972044914504 0.999391635540124 0.999897403075094 0 0 0.4592581264399 0 0 0.602364635616474 0 0 0.4592581264399 0 0 5.56435874081596 0.584304457175194 200 2040 False False 0 0 3.1200699364824 0 0 0.000631133876986172 0.99972044914504 0.999391635540124 0.999897403075094 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 4 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Asn5Lys Rv1129c_p.Asn5Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Asn5Ser Rv1129c_p.Asn5Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 19.5657623867404 1 883 2040 False False 0 0 5.56487735727821 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Asp160Ala Rv1129c_p.Asp160Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 37 1 36 22 59 5821 21404 0.00376518911518055 0.0023610823891641 0.00569502395783134 0.997251083259563 0.996455511261334 0.997906758675919 0.271604938271604 0.178683418535085 0.381852755075493 0.027027027027027 0.000684031024694665 0.141603095611158 0.0166666666666666 0.000421874452342009 0.089399050057487 0.102139762163813 0.00252040672738804 0.606843643271458 0.00224356805804758 29 2040 False False 1.37109646836847 0.799236608471057 2.27367849213613 0.000171762281003091 4.34863499403935e-06 0.000956622527653742 0.997251083259563 0.996455511261334 0.997906758675919 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 20 0 20 13 31 2707 9608 0.00477941176470588 0.00254721544199456 0.00815907242338076 0.996783898744683 0.995438080810104 0.997813801049638 0.295454545454545 0.167643981228676 0.452021848084055 0 0 0.168433470983085 0 0 0.11218874692237 0 0 0.719521934317833 0.0122851896516985 24 1102 False False 0 0 0 0 0 0 0 1.48842308471465 0.713772292976438 2.93259753938771 0 0 0.00136179059585261 0.996783898744683 0.995438080810104 0.997813801049638 52 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Asp160Asn Rv1129c_p.Asp160Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 3 3 5840 21460 0.000513434879342803 0.000105895133877182 0.00149973424244328 0.99986022457252 0.999591571764338 0.999971174018896 0.5 0.118117248757025 0.881882751242974 0 0 0.841886116991581 0 0 0.707598226178713 0 0 19.5766929980907 1 319.5 2040 False False 3.67465753424657 0.492014255735427 27.463249173756 0 0 0.000631457987209345 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 2718 9638 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 0.999896254798215 0.999422105789591 0.999997373402351 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 138.011851332821 1 457.5 1102 False False 0 0 0 0 0 0 0 7.09197939661515 0.368993183584618 417.296682266591 0 0 0.00135628304118183 0.999896254798215 0.999422105789591 0.999997373402351 6 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Asp160Glu Rv1129c_p.Asp160Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 142.927071297039 1 883 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 137.896313968788 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Asp160Gly Rv1129c_p.Asp160Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 3 6 5840 21457 0.000513434879342803 0.000105895133877182 0.00149973424244328 0.99972044914504 0.999391635540124 0.999897403075094 0.333333333333333 0.0748546314196918 0.700704943791459 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.12167448377835 0.352612436949125 163 2040 False False 1.83707191780821 0.297196397505327 8.60517731171929 0 0 0.000631457987209345 0.99972044914504 0.999391635540124 0.999897403075094 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 1 4 2719 9635 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999585019192862 0.998937828281888 0.999886920491758 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.37091971678909 0.582315775027881 122 1102 False False 0 0 0 0 0 0 0 0.885895549834498 0.0179820541723419 8.95537117058933 0 0 0.0013557845626193 0.999585019192862 0.998937828281888 0.999886920491758 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Asp164His Rv1129c_p.Asp164His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1896 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Asp191Ala Rv1129c_p.Asp191Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1864 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Asp191Gly Rv1129c_p.Asp191Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 13 1 12 2 12 5841 21451 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99944089829008 0.999023565718772 0.999711071680148 0.142857142857142 0.0177945154831915 0.428129160909698 0.0769230769230769 0.00194562849734675 0.360297435267877 0.0769230769230769 0.00194562849734675 0.360297435267877 0.306040632311818 0.00716154986169146 2.06928880798903 0.323270978388904 141 2040 False False 0.612081264623637 0.0665160862429459 2.75060668897979 0.000171174255391989 4.33374753915718e-06 0.000953348826018904 0.99944089829008 0.999023565718772 0.999711071680148 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 12 1 11 2 11 2718 9628 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 0.998858802780371 0.997959002506684 0.999430185159088 0.153846153846153 0.0192066719825284 0.454471055676557 0.0833333333333333 0.00210759323186022 0.384796165150944 0.0833333333333333 0.00210759323186022 0.384796165150944 0.322028229312997 0.00748235514816047 2.21770171897444 0.483177255976429 105 1102 False False 0 0 0 0 0 0 0 0.644056458625995 0.0693292297749493 2.95377394205033 0.000367782272894446 9.31139761383543e-06 0.00204742980952803 0.998858802780371 0.997959002506684 0.999430185159088 12 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Asp200Ala Rv1129c_p.Asp200Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 1 5841 21462 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99995340819084 0.99974043469953 0.999998820398217 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 1926 2040 False False 7.3487416538264 0.382468755528661 432.333734199629 0 0 0.000631349913487419 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1051 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Asp200Asn Rv1129c_p.Asp200Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1962 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Asp209Gly Rv1129c_p.Asp209Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1958 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Asp214Asn Rv1129c_p.Asp214Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 2 5842 21461 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99990681638168 0.999663429698698 0.999988714832292 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1921 2040 False False 1.83678534748373 0.0311281139040964 35.2896458967866 0 0 0.00063124187675269 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1047 1102 False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 0 0 0.0013557845626193 0.999896254798215 0.999422105789591 0.999997373402351 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Asp223His Rv1129c_p.Asp223His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Asp262Gly Rv1129c_p.Asp262Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 3 1 5840 21462 0.000513434879342803 0.000105895133877182 0.00149973424244328 0.99995340819084 0.99974043469953 0.999998820398217 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 1923 2040 False False 11.025 0.884946155157416 576.804300084131 0 0 0.000631457987209345 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1049 1102 False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 0 0 0.0013557845626193 0.999896254798215 0.999422105789591 0.999997373402351 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Asp302Asn Rv1129c_p.Asp302Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1913 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1041 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Asp387Gly Rv1129c_p.Asp387Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.56487735727821 0.58431003819195 215.5 2040 False False 0 0 5.56487735727821 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Asp419Asn Rv1129c_p.Asp419Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1865 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Asp41Asn Rv1129c_p.Asp41Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1907 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1037 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Asp87Glu Rv1129c_p.Asp87Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Gln105Glu Rv1129c_p.Gln105Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 2 5842 21461 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99990681638168 0.999663429698698 0.999988714832292 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1938 2040 False False 1.83678534748373 0.0311281139040964 35.2896458967866 0 0 0.00063124187675269 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1057 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 10 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Gln105Pro Rv1129c_p.Gln105Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 2 3 5841 21460 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99986022457252 0.999591571764338 0.999971174018896 0.4 0.0527449505263169 0.853367200365326 0 0 0.841886116991581 0 0 0.707598226178713 0 0 19.5733512949936 1 883 2040 False False 2.44935227986075 0.204519727205419 21.3860749684357 0 0 0.000631349913487419 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 1 2718 9638 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 0.999896254798215 0.999422105789591 0.999997373402351 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 1020 1102 False False 0 0 0 0 0 0 0 7.09197939661515 0.368993183584618 417.296682266591 0 0 0.00135628304118183 0.999896254798215 0.999422105789591 0.999997373402351 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Gln237Pro Rv1129c_p.Gln237Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Gln329Pro Rv1129c_p.Gln329Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 2 4 5841 21459 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99981363276336 0.999522895233871 0.999949218940757 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.56678314392968 0.584330550233303 241.5 2040 False False 1.83692860811504 0.166109303397098 12.8208569329986 0 0 0.000631349913487419 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 2719 9637 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999792509596431 0.999250676427901 0.999974870961701 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8778635755656 1 457.5 1102 False False 0 0 0 0 0 0 0 1.77215888194189 0.0300270423699391 34.0580978516331 0 0 0.0013557845626193 0.999792509596431 0.999250676427901 0.999974870961701 6 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Gln384His Rv1129c_p.Gln384His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 5841 21462 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99995340819084 0.99974043469953 0.999998820398217 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 142.989195698265 1 319.5 2040 False False 7.3487416538264 0.382468755528661 432.333734199629 0 0 0.000631349913487419 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Gln74His Rv1129c_p.Gln74His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 142.964774304408 1 883 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0 0 0.00063124187675269 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Glu107Asp Rv1129c_p.Glu107Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 3 6 5840 21457 0.000513434879342803 0.000105895133877182 0.00149973424244328 0.99972044914504 0.999391635540124 0.999897403075094 0.333333333333333 0.0748546314196918 0.700704943791459 0 0 0.521823750104981 0 0 0.4592581264399 0 0 4.01062284846839 0.591559347204345 252 2040 False False 1.83707191780821 0.297196397505327 8.60517731171929 0 0 0.000631457987209345 0.99972044914504 0.999391635540124 0.999897403075094 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 3 5 2717 9634 0.00110294117647058 0.000227510766880298 0.0032198465640147 0.999481273991078 0.998789885214303 0.999831550309162 0.375 0.0852334141372535 0.755136783633448 0 0 0.521823750104981 0 0 0.521823750104981 0 0 3.87179517166676 0.592732997196903 130 1102 False False 0 0 0 0 0 0 0 2.1274935590725 0.33015750003891 10.9437900675457 0 0 0.00135678188642832 0.999481273991078 0.998789885214303 0.999831550309162 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Glu115Ala Rv1129c_p.Glu115Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1891 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0 0 0.00063124187675269 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1028 1102 False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 0 0 0.0013557845626193 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Glu133Asp Rv1129c_p.Glu133Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 11 9 5832 21454 0.00188259455759027 0.000940147291275547 0.00336597924963922 0.99958067371756 0.999204138016772 0.999808239967157 0.55 0.315278133040548 0.769422103224075 0 0 0.521823750104981 0 0 0.336267116879942 0 0 4.0155640200334 0.591524607870956 247 2040 False False 4.49615150129553 1.6928117229645 12.2806561586788 0 0 0.000632323910806262 0.99958067371756 0.999204138016772 0.999808239967157 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 10 6 2710 9633 0.00367647058823529 0.0017643752042604999 0.00675073416095428 0.999377528789293 0.998645638320949 0.999771530871485 0.625 0.354346094302078 0.848016324918877 0 0 0.707598226178713 0 0 0.4592581264399 0 0 8.60750400733887 1 457.5 1102 False False 0 0 0 0 0 0 0 5.92435424354243 1.94845367374785 19.8470431154833 0 0 0.00136028410437921 0.999377528789293 0.998645638320949 0.999771530871485 5 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Glu133Lys Rv1129c_p.Glu133Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 3 4 5840 21459 0.000513434879342803 0.000105895133877182 0.00149973424244328 0.99981363276336 0.999522895233871 0.999949218940757 0.428571428571428 0.0989882784425078 0.815948432359917 0 0 0.707598226178713 0 0 0.602364635616474 0 0 8.89562074397505 1 883 2040 False False 2.75586472602739 0.403561343422743 16.2923812675514 0 0 0.000631457987209345 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 137.961202437293 1 457.5 1102 False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 0 0 0.0013557845626193 0.999896254798215 0.999422105789591 0.999997373402351 5 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Glu135Ala Rv1129c_p.Glu135Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 12 14 5831 21449 0.00205373951737121 0.00106163336321942 0.00358471862336565 0.99934771467176 0.998905818000026 0.999643345117175 0.461538461538461 0.265871217422951 0.666291781524707 0 0 0.409616397225003 0 0 0.231635761650116 0 0 2.55295261071194 0.358150392062745 165 2040 False False 3.15295097630889 1.33131405864208 7.34723986019774 0 0 0.000632432318269409 0.99934771467176 0.998905818000026 0.999643345117175 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 4 4 2716 9635 0.00147058823529411 0.000400826576335422 0.00376097173045195 0.999585019192862 0.998937828281888 0.999886920491758 0.5 0.157012770487058 0.842987229512941 0 0 0.841886116991581 0 0 0.602364635616474 0 0 18.8947942135327 1 457.5 1102 False False 0 0 0 0 0 0 0 3.54749631811487 0.660201236530047 19.0539091964982 0 0 0.00135728109876354 0.999585019192862 0.998937828281888 0.999886920491758 31 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Glu135Gln Rv1129c_p.Glu135Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 19.5666713375759 1 883 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Glu135Gly Rv1129c_p.Glu135Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 1 6 5842 21457 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99972044914504 0.999391635540124 0.999897403075094 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.602364635616474 0 0 0.4592581264399 0 0 5.56531138221033 0.584314704024368 230 2040 False False 0.612147666324318 0.0133096260827154 5.04744841661085 0 0 0.00063124187675269 0.99972044914504 0.999391635540124 0.999897403075094 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1026 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 13 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Glu135Lys Rv1129c_p.Glu135Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 4 8 5839 21455 0.000684579839123737 0.000186555462570677 0.00175186028923716 0.99962726552672 0.99926569731444 0.999839066414514 0.333333333333333 0.0992460911495833 0.651124493581186 0 0 0.4592581264399 0 0 0.369416647552819 0 0 3.12191844475348 0.352618569321227 164 2040 False False 1.83721527658845 0.404699580750889 6.859379994512 0 0 0.000631566097937464 0.99962726552672 0.99926569731444 0.999839066414514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 2 2 2718 9637 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 0.999792509596431 0.999250676427901 0.999974870961701 0.5 0.067585986488543 0.932414013511457 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8848089598515 1 457.5 1102 False False 0 0 0 0 0 0 0 3.54562178072111 0.256860512408561 48.9209196354209 0 0 0.00135628304118183 0.999792509596431 0.999250676427901 0.999974870961701 5 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Glu146Lys Rv1129c_p.Glu146Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Glu146Val Rv1129c_p.Glu146Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Glu156Gly Rv1129c_p.Glu156Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1877 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1025 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Glu157Gly Rv1129c_p.Glu157Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1889 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Glu440Ala Rv1129c_p.Glu440Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1936 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1056 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 7 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Glu471Asp Rv1129c_p.Glu471Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Glu98Ala Rv1129c_p.Glu98Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1890 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Glu98Gly Rv1129c_p.Glu98Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 3 2 5840 21461 0.000513434879342803 0.000105895133877182 0.00149973424244328 0.99990681638168 0.999663429698698 0.999988714832292 0.6 0.146632799634673 0.947255049473683 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5776024209454 1 883 2040 False False 5.51224315068493 0.63123591332421 66.0805594851213 0 0 0.000631457987209345 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Glu98Lys Rv1129c_p.Glu98Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 12 0 12 0 16 5843 21447 0 0 0.000631133876986172 0.99925453105344 0.998789686679379 0.999573841954248 0 0 0.205907214207822 0 0 0.264648469397051 0 0 0.205907214207822 0 0 1.3214900668112 0.0822807705307932 68 2040 False False 0 0 0.952125276634789 0 0 0.000631133876986172 0.99925453105344 0.998789686679379 0.999573841954248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 0 11 2720 9628 0 0 0.00135528645033659 0.998858802780371 0.997959002506684 0.999430185159088 0 0 0.284914152918154 0 0 0.30849710781876 0 0 0.284914152918154 0 0 1.58035097305676 0.131070616777933 48.5 1102 False False 0 0 0 0 0 0 0 0 0 1.41143234851738 0 0 0.00135528645033659 0.998858802780371 0.997959002506684 0.999430185159088 4 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Gly103Ala Rv1129c_p.Gly103Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1866 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Gly103Asp Rv1129c_p.Gly103Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1945 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Gly117Ala Rv1129c_p.Gly117Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1949 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Gly184Ala Rv1129c_p.Gly184Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Gly188Arg Rv1129c_p.Gly188Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1946 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Gly189Glu Rv1129c_p.Gly189Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Gly19Ala Rv1129c_p.Gly19Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5841 21463 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 1 0.999828143201531 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1904 2040 False False Inf 0.689929368506768 Inf 0 0 0.000631349913487419 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 2718 9639 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 1 0.999617369678334 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1035 1102 False False 0 0 0 0 0 0 0 Inf 0.665658435310444 Inf 0 0 0.00135628304118183 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Gly236Glu Rv1129c_p.Gly236Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1927 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1052 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Gly250Arg Rv1129c_p.Gly250Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Gly271Ser Rv1129c_p.Gly271Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 5843 21458 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.0087500478358 0.59157266040946 268 2040 False False 0 0 4.0087500478358 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Gly311Glu Rv1129c_p.Gly311Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 1 4 5842 21459 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99981363276336 0.999522895233871 0.999949218940757 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.56583008746417 0.58432028936451 238 2040 False False 0.918307086614173 0.0186435710006194 9.27999188457764 0 0 0.00063124187675269 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Gly360Asp Rv1129c_p.Gly360Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 3 5842 21460 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99986022457252 0.999591571764338 0.999971174018896 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 19.5700107416863 1 883 2040 False False 1.22446650690402 0.0233203404016305 15.2512395040111 0 0 0.00063124187675269 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 2719 9637 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999792509596431 0.999250676427901 0.999974870961701 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 137.946920474639 1 457.5 1102 False False 0 0 0 0 0 0 0 1.77215888194189 0.0300270423699391 34.0580978516331 0 0 0.0013557845626193 0.999792509596431 0.999250676427901 0.999974870961701 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Gly360Ser Rv1129c_p.Gly360Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1924 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1050 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Gly360Val Rv1129c_p.Gly360Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1909 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Gly361Ala Rv1129c_p.Gly361Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 5841 21462 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99995340819084 0.99974043469953 0.999998820398217 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 142.989195698265 1 319.5 2040 False False 7.3487416538264 0.382468755528661 432.333734199629 0 0 0.000631349913487419 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 137.961202437293 1 457.5 1102 False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 0 0 0.0013557845626193 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Gly361Asp Rv1129c_p.Gly361Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 142.93371627475 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 137.896313968788 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Gly361Cys Rv1129c_p.Gly361Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 3 5842 21460 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99986022457252 0.999591571764338 0.999971174018896 0.25 0.00630946320970987 0.805879550316756 0 0 0.975 0 0 0.707598226178713 0 0 142.951482085634 1 883 2040 False False 1.22446650690402 0.0233203404016305 15.2512395040111 0 0 0.00063124187675269 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1022 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Gly361Ser Rv1129c_p.Gly361Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 19.5666713375759 1 883 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Gly361Val Rv1129c_p.Gly361Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Gly402Arg Rv1129c_p.Gly402Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1881 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Gly402Glu Rv1129c_p.Gly402Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 12 0 12 3 16 5840 21447 0.000513434879342803 0.000105895133877182 0.00149973424244328 0.99925453105344 0.998789686679379 0.999573841954248 0.157894736842105 0.0338262490017646 0.395784551266674 0 0 0.264648469397051 0 0 0.205907214207822 0 0 1.32216908056914 0.0823034579279701 71 2040 False False 0.688580907534246 0.12853187780768 2.40678977518753 0 0 0.000631457987209345 0.99925453105344 0.998789686679379 0.999573841954248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 3 11 2717 9628 0.00110294117647058 0.000227510766880298 0.0032198465640147 0.998858802780371 0.997959002506684 0.999430185159088 0.214285714285714 0.0465792878898673 0.507975677048471 0 0 0.369416647552819 0 0 0.284914152918154 0 0 2.07747027967292 0.213360045523787 67 1102 False False 0 0 0 0 0 0 0 0.966440258306287 0.172995378784575 3.6615872502279 0 0 0.00135678188642832 0.998858802780371 0.997959002506684 0.999430185159088 22 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Gly404Ala Rv1129c_p.Gly404Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1925 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Gly407Ser Rv1129c_p.Gly407Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1867 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Gly415Val Rv1129c_p.Gly415Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5841 21463 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 1 0.999828143201531 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1931 2040 False False Inf 0.689929368506768 Inf 0 0 0.000631349913487419 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 2718 9639 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 1 0.999617369678334 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1054 1102 False False 0 0 0 0 0 0 0 Inf 0.665658435310444 Inf 0 0 0.00135628304118183 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Gly431Arg Rv1129c_p.Gly431Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1950 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1062 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Gly446Cys Rv1129c_p.Gly446Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 142.93371627475 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Gly446Ser Rv1129c_p.Gly446Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5841 21463 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 1 0.999828143201531 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1872 2040 False False Inf 0.689929368506768 Inf 0 0 0.000631349913487419 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Gly446Val Rv1129c_p.Gly446Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89146792489366 1 319.5 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Gly474Asp Rv1129c_p.Gly474Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 142.93371627475 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1029 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Gly474Ser Rv1129c_p.Gly474Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Gly96Arg Rv1129c_p.Gly96Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1951 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1063 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.His118Pro Rv1129c_p.His118Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1955 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1066 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.His231Pro Rv1129c_p.His231Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1908 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.His293Asn Rv1129c_p.His293Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1932 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.His355Arg Rv1129c_p.His355Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Ile106Val Rv1129c_p.Ile106Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1947 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Ile303Leu Rv1129c_p.Ile303Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1963 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1069 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Ile303Thr Rv1129c_p.Ile303Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5841 21463 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 1 0.999828143201531 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1899 2040 False False Inf 0.689929368506768 Inf 0 0 0.000631349913487419 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1031 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Ile332Met Rv1129c_p.Ile332Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5841 21463 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 1 0.999828143201531 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1886 2040 False False Inf 0.689929368506768 Inf 0 0 0.000631349913487419 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 2718 9639 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 1 0.999617369678334 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1027 1102 False False 0 0 0 0 0 0 0 Inf 0.665658435310444 Inf 0 0 0.00135628304118183 1 0.999617369678334 1 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Ile332Thr Rv1129c_p.Ile332Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1897 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1030 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Ile378Met Rv1129c_p.Ile378Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1905 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Ile443Met Rv1129c_p.Ile443Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Ile443Thr Rv1129c_p.Ile443Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 3 6 5840 21457 0.000513434879342803 0.000105895133877182 0.00149973424244328 0.99972044914504 0.999391635540124 0.999897403075094 0.333333333333333 0.0748546314196918 0.700704943791459 0.333333333333333 0.00840375865961264 0.905700675949754 0.142857142857142 0.00361029686190058 0.578723197043195 1.83707191780821 0.0311329686403615 35.2907047979827 0.514345399659875 192 2040 False False 1.83707191780821 0.297196397505327 8.60517731171929 0.000171203561034069 4.33448949056051e-06 0.000953511978863128 0.99972044914504 0.999391635540124 0.999897403075094 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1055 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Ile443Val Rv1129c_p.Ile443Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Ile449Val Rv1129c_p.Ile449Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1942 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1059 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Ile95Thr Rv1129c_p.Ile95Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1882 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Ile95Val Rv1129c_p.Ile95Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Leu127Val Rv1129c_p.Leu127Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Leu134Pro Rv1129c_p.Leu134Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 6 5843 21457 0 0 0.000631133876986172 0.99972044914504 0.999391635540124 0.999897403075094 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 4.00856324322819 0.591573991022433 278.5 2040 False False 0 0 3.1200699364824 0 0 0.000631133876986172 0.99972044914504 0.999391635540124 0.999897403075094 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Leu172Val Rv1129c_p.Leu172Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Leu190Ser Rv1129c_p.Leu190Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89146792489366 1 319.5 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Leu212Arg Rv1129c_p.Leu212Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 8 6 5835 21457 0.00136915967824747 0.00059128544285425 0.00269599843431209 0.99972044914504 0.999391635540124 0.999897403075094 0.571428571428571 0.288609400038307 0.823388910017882 0 0 0.841886116991581 0 0 0.4592581264399 0 0 19.5906881539157 1 883 2040 False False 4.90305626963724 1.4910845918339 17.1509006863593 0 0 0.00063199891129229 0.99972044914504 0.999391635540124 0.999897403075094 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 4 5 2716 9634 0.00147058823529411 0.000400826576335422 0.00376097173045195 0.999481273991078 0.998789885214303 0.999831550309162 0.444444444444444 0.136995662265166 0.787991493221131 0 0 0.841886116991581 0 0 0.521823750104981 0 0 18.8928337782972 1 457.5 1102 False False 0 0 0 0 0 0 0 2.83770250368188 0.562638624808286 13.1895150661285 0 0 0.00135728109876354 0.999481273991078 0.998789885214303 0.999831550309162 7 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Leu212Pro Rv1129c_p.Leu212Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 2 4 5841 21459 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99981363276336 0.999522895233871 0.999949218940757 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.56678314392968 0.584330550233303 241.5 2040 False False 1.83692860811504 0.166109303397098 12.8208569329986 0 0 0.000631349913487419 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 1 4 2719 9635 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999585019192862 0.998937828281888 0.999886920491758 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.37091971678909 0.582315775027881 122 1102 False False 0 0 0 0 0 0 0 0.885895549834498 0.0179820541723419 8.95537117058933 0 0 0.0013557845626193 0.999585019192862 0.998937828281888 0.999886920491758 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Leu227Phe Rv1129c_p.Leu227Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Leu265Phe Rv1129c_p.Leu265Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Leu299Ser Rv1129c_p.Leu299Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1878 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Leu305Pro Rv1129c_p.Leu305Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1916 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1044 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Leu306Met Rv1129c_p.Leu306Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Leu321Phe Rv1129c_p.Leu321Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 2 3 5841 21460 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99986022457252 0.999591571764338 0.999971174018896 0.4 0.0527449505263169 0.853367200365326 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89451223755799 1 883 2040 False False 2.44935227986075 0.204519727205419 21.3860749684357 0 0 0.000631349913487419 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.57852451631077 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 8.57852451631077 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Leu420Arg Rv1129c_p.Leu420Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Leu426Ile Rv1129c_p.Leu426Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Leu477Phe Rv1129c_p.Leu477Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1917 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Lys217Asn Rv1129c_p.Lys217Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Lys225Asn Rv1129c_p.Lys225Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1939 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1058 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Lys341Asn Rv1129c_p.Lys341Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1887 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Lys425Arg Rv1129c_p.Lys425Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Lys425Thr Rv1129c_p.Lys425Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89146792489366 1 319.5 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Lys448Thr Rv1129c_p.Lys448Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1918 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1045 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Met1? Rv1129c_p.Met1? 2 start_lost (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 5841 21462 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99995340819084 0.99974043469953 0.999998820398217 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 142.989195698265 1 319.5 2040 False False 7.3487416538264 0.382468755528661 432.333734199629 0 0 0.000631349913487419 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 137.961202437293 1 457.5 1102 False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 0 0 0.0013557845626193 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Met113Ile Rv1129c_p.Met113Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 8.89105370607792 1 883 2040 False False 0 0 5.56487735727821 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 2720 9635 0 0 0.00135528645033659 0.999585019192862 0.998937828281888 0.999886920491758 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 8.57763452631882 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 5.36894442066688 0 0 0.00135528645033659 0.999585019192862 0.998937828281888 0.999886920491758 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Met113Thr Rv1129c_p.Met113Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 142.93371627475 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Met153Ile Rv1129c_p.Met153Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 142.927071297039 1 883 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Met179Ile Rv1129c_p.Met179Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89146792489366 1 319.5 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Phe109Leu Rv1129c_p.Phe109Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Phe180Leu Rv1129c_p.Phe180Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1959 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1067 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Phe202Tyr Rv1129c_p.Phe202Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 24 1 23 69 28 5774 21435 0.0118090022248844 0.00919940660280315 0.0149215714819186 0.998695429343521 0.998115079868827 0.999132952674816 0.711340206185567 0.610483479581775 0.798867036286455 0.0416666666666666 0.00105435244546974 0.211201683456973 0.0344827586206896 0.000872646883579922 0.177644295488722 0.161405701721359 0.00392129632608352 0.99444862166571 0.0432712192393658 54 2040 False False 9.14824459399277 5.81224070726193 14.7584007645588 0.000173160173160173 4.3840264047238e-06 0.000964404945591843 0.998695429343521 0.998115079868827 0.999132952674816 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 11 4 2709 9635 0.00404411764705882 0.00202048490520436 0.0072244966118925 0.999585019192862 0.998937828281888 0.999886920491758 0.733333333333333 0.448996758963029 0.922128453708956 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.39075291481133 0.582502074632158 128 1102 False False 0 0 0 0 0 0 0 9.78082318198597 2.89461615918713 42.1494090508869 0 0 0.00136078589771868 0.999585019192862 0.998937828281888 0.999886920491758 13 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Phe334Leu Rv1129c_p.Phe334Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 3 11 5840 21452 0.000513434879342803 0.000105895133877182 0.00149973424244328 0.99948749009924 0.999083163687746 0.999744130025508 0.214285714285714 0.0465792878898673 0.507975677048471 NA NA NA 0 0 0.284914152918154 NA NA NA NA 1914 2040 False False 1.00180572851805 0.17939512520377 3.79405161373115 0 0 0.000631457987209345 0.99948749009924 0.999083163687746 0.999744130025508 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 6 2719 9633 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999377528789293 0.998645638320949 0.999771530871485 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1042 1102 False False 0 0 0 0 0 0 0 0.590474439132033 0.0128360606385712 4.87020043259644 0 0 0.0013557845626193 0.999377528789293 0.998645638320949 0.999771530871485 16 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Phe356Val Rv1129c_p.Phe356Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Phe412Leu Rv1129c_p.Phe412Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Phe460Leu Rv1129c_p.Phe460Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 142.93371627475 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Phe460Val Rv1129c_p.Phe460Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Pro149Leu Rv1129c_p.Pro149Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1870 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Pro408Ser Rv1129c_p.Pro408Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Pro437Leu Rv1129c_p.Pro437Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1933 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Pro461Arg Rv1129c_p.Pro461Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1910 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Pro461Leu Rv1129c_p.Pro461Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1900 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Pro8fs Rv1129c_p.Pro8fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Ser119Arg Rv1129c_p.Ser119Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1922 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1048 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Ser119Asn Rv1129c_p.Ser119Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 142.927071297039 1 883 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 137.882037227845 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 8.57852451631077 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Ser119Gly Rv1129c_p.Ser119Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Ser14Leu Rv1129c_p.Ser14Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Ser357Arg Rv1129c_p.Ser357Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1884 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Ser357Asn Rv1129c_p.Ser357Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1964 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1070 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Ser357Gly Rv1129c_p.Ser357Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1965 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1071 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Ser438Thr Rv1129c_p.Ser438Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Ser454Ala Rv1129c_p.Ser454Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0941866911272879 Inf 0.213982274957884 105.5 2040 False False Inf 0.0941866911272879 Inf 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Ser475Arg Rv1129c_p.Ser475Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 19.5666713375759 1 883 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 137.896313968788 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Ser476Asn Rv1129c_p.Ser476Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Ser480Pro Rv1129c_p.Ser480Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 16 0 16 0 20 5843 21443 0 0 0.000631133876986172 0.999068163816801 0.998561219655491 0.999430720271997 0 0 0.168433470983085 0 0 0.205907214207822 0 0 0.168433470983085 0 0 0.95194767979073 0.0318583577027625 49 2040 False False 0 0 0.743599190444509 0 0 0.000631133876986172 0.999068163816801 0.998561219655491 0.999430720271997 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 13 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Thr12Met Rv1129c_p.Thr12Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 14 1 13 6 14 5837 21449 0.0010268697586856 0.000376933373413978 0.00223371319186393 0.99934771467176 0.998905818000026 0.999643345117175 0.3 0.118931590405727 0.542789182276289 0.0714285714285714 0.00180678065912538 0.338684489931821 0.0666666666666666 0.0016864302413527 0.319484566578303 0.282666280096466 0.00665374933740277 1.88271452482681 0.326853603894336 143 2040 False False 1.57485498910888 0.495808664270027 4.36478056124371 0.000171291538198013 4.33671686984716e-06 0.000954001772624896 0.99934771467176 0.998905818000026 0.999643345117175 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 12 1 11 6 12 2714 9627 0.00220588235294117 0.000809936709089192 0.00479504888600855 0.998755057578587 0.997826347023296 0.999356559855396 0.333333333333333 0.133427402506123 0.590074761827925 0.0833333333333333 0.00210759323186022 0.384796165150944 0.0769230769230769 0.00194562849734675 0.360297435267877 0.322469350840758 0.00749259475160213 2.2207415537225 0.483067749882762 104 1102 False False 0 0 0 0 0 0 0 1.77358142962417 0.545608704324614 5.11139424192324 0.000368324125230202 9.32511599939531e-06 0.00205044374137956 0.998755057578587 0.997826347023296 0.999356559855396 6 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Thr131Ala Rv1129c_p.Thr131Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 2 2 5841 21461 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99990681638168 0.999663429698698 0.999988714832292 0.5 0.067585986488543 0.932414013511457 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5742605605944 1 883 2040 False False 3.67419962335216 0.266252080252227 50.6812073544246 0 0 0.000631349913487419 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 137.961202437293 1 457.5 1102 False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 0 0 0.0013557845626193 0.999896254798215 0.999422105789591 0.999997373402351 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Thr131Ile Rv1129c_p.Thr131Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Thr131Pro Rv1129c_p.Thr131Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 32 1 31 9 39 5834 21424 0.00154030463802841 0.000704559638966774 0.00292195530235611 0.998182919442762 0.997516819563471 0.998707568843746 0.1875 0.0894983818493728 0.326293023956713 0.03125 0.000790868597952557 0.162170994181511 0.025 0.000632744932049419 0.131585858482765 0.118460194410961 0.00290993943514675 0.711143154344535 0.00812714073364744 35 2040 False False 0.847446006170723 0.36076441439221 1.77989632746102 0.000171379605826906 4.33894653949314e-06 0.000954492069833317 0.998182919442762 0.997516819563471 0.998707568843746 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 19 0 19 4 22 2716 9617 0.00147058823529411 0.000400826576335422 0.00376097173045195 0.997717605560742 0.996546454687636 0.998569099943935 0.153846153846153 0.0435634765389238 0.348678785535361 0 0 0.176466911806965 0 0 0.154372512815574 0 0 0.759413167950569 0.0122213221964099 23 1102 False False 0 0 0 0 0 0 0 0.643794349979917 0.161131212900895 1.89787993616517 0 0 0.00135728109876354 0.997717605560742 0.996546454687636 0.998569099943935 20 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Thr145Ile Rv1129c_p.Thr145Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Thr187Asn Rv1129c_p.Thr187Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Thr215Ala Rv1129c_p.Thr215Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 5841 21462 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99995340819084 0.99974043469953 0.999998820398217 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 142.989195698265 1 319.5 2040 False False 7.3487416538264 0.382468755528661 432.333734199629 0 0 0.000631349913487419 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Thr261Pro Rv1129c_p.Thr261Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 8 5 5835 21458 0.00136915967824747 0.00059128544285425 0.00269599843431209 0.9997670409542 0.99945643574724 0.999924354643808 0.615384615384615 0.315777602914063 0.861420661109839 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.01424729234419 0.591533815633294 248.5 2040 False False 5.88394173093401 1.69631346127004 22.8659263023028 0 0 0.00063199891129229 0.9997670409542 0.99945643574724 0.999924354643808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 8 5 2712 9634 0.00294117647058823 0.00127061997302132 0.00578702225151795 0.999481273991078 0.998789885214303 0.999831550309162 0.615384615384615 0.315777602914063 0.861420661109839 0 0 0.521823750104981 0 0 0.521823750104981 0 0 3.87893629590262 0.592658833090023 129 1102 False False 0 0 0 0 0 0 0 5.68377581120944 1.63766536096422 22.0958178027468 0 0 0.00135928162710748 0.999481273991078 0.998789885214303 0.999831550309162 13 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Thr2Ala Rv1129c_p.Thr2Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89146792489366 1 319.5 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 5 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Thr2Met Rv1129c_p.Thr2Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5841 21463 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 1 0.999828143201531 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1879 2040 False False Inf 0.689929368506768 Inf 0 0 0.000631349913487419 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Thr323Ala Rv1129c_p.Thr323Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 4 5 5839 21458 0.000684579839123737 0.000186555462570677 0.00175186028923716 0.9997670409542 0.99945643574724 0.999924354643808 0.444444444444444 0.136995662265166 0.787991493221131 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.0114967866183 0.591553164564255 251 2040 False False 2.93995547182736 0.583155126092397 13.6594714584342 0 0 0.000631566097937464 0.9997670409542 0.99945643574724 0.999924354643808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 137.961202437293 1 457.5 1102 False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 0 0 0.0013557845626193 0.999896254798215 0.999422105789591 0.999997373402351 17 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Thr430Pro Rv1129c_p.Thr430Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 3 5842 21460 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99986022457252 0.999591571764338 0.999971174018896 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 19.5700107416863 1 883 2040 False False 1.22446650690402 0.0233203404016305 15.2512395040111 0 0 0.00063124187675269 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 4 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Thr439Ala Rv1129c_p.Thr439Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1874 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1023 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Thr44Ile Rv1129c_p.Thr44Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1937 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Thr453Met Rv1129c_p.Thr453Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1940 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Trp232Gly Rv1129c_p.Trp232Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 17 1 16 3 19 5840 21444 0.000513434879342803 0.000105895133877182 0.00149973424244328 0.999114755625961 0.998617924918733 0.999466943572351 0.136363636363636 0.0290558511287467 0.349122097257408 0.0588235294117647 0.00148817439126663 0.28688939666722 0.05 0.0012650894979498 0.248732762772027 0.229494863013698 0.00547527916268343 1.47792975155118 0.146198091508978 86 2040 False False 0.579776496034607 0.109826852344941 1.97055104839814 0.000171203561034069 4.33448949056051e-06 0.000953511978863128 0.999114755625961 0.998617924918733 0.999466943572351 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 2719 9637 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999792509596431 0.999250676427901 0.999974870961701 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8778635755656 1 457.5 1102 False False 0 0 0 0 0 0 0 1.77215888194189 0.0300270423699391 34.0580978516331 0 0 0.0013557845626193 0.999792509596431 0.999250676427901 0.999974870961701 15 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Trp366Cys Rv1129c_p.Trp366Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5841 21463 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 1 0.999828143201531 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1880 2040 False False Inf 0.689929368506768 Inf 0 0 0.000631349913487419 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Tyr137Asn Rv1129c_p.Tyr137Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5841 21463 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 1 0.999828143201531 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1944 2040 False False Inf 0.689929368506768 Inf 0 0 0.000631349913487419 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 2718 9639 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 1 0.999617369678334 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1061 1102 False False 0 0 0 0 0 0 0 Inf 0.665658435310444 Inf 0 0 0.00135628304118183 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Tyr137Asp Rv1129c_p.Tyr137Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 3 5840 21460 0.000513434879342803 0.000105895133877182 0.00149973424244328 0.99986022457252 0.999591571764338 0.999971174018896 0.5 0.118117248757025 0.881882751242974 0 0 0.975 0 0 0.707598226178713 0 0 143.000328686365 1 883 2040 False False 3.67465753424657 0.492014255735427 27.463249173756 0 0 0.000631457987209345 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1064 1102 False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 0 0 0.0013557845626193 0.999896254798215 0.999422105789591 0.999997373402351 7 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Tyr137Cys Rv1129c_p.Tyr137Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5841 21463 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 1 0.999828143201531 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1873 2040 False False Inf 0.689929368506768 Inf 0 0 0.000631349913487419 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Tyr137His Rv1129c_p.Tyr137His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1930 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1053 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Tyr137Ser Rv1129c_p.Tyr137Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1956 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Tyr301His Rv1129c_p.Tyr301His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1875 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1024 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Tyr462Cys Rv1129c_p.Tyr462Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 3.67374186922286 0.0467931454016956 287.712465214691 0.382182295738733 180 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 3.54468554615667 0.045140524816893 277.645286351599 0.391742630950597 101.5 1102 False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Tyr462His Rv1129c_p.Tyr462His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1888 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Val110Phe Rv1129c_p.Val110Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1868 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1019 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Val116Phe Rv1129c_p.Val116Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 5842 21460 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99986022457252 0.999591571764338 0.999971174018896 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89298982087011 1 883 2040 False False 1.22446650690402 0.0233203404016305 15.2512395040111 0 0 0.00063124187675269 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Val226Leu Rv1129c_p.Val226Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Val259Ala Rv1129c_p.Val259Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 5 5843 21458 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 8.89063948722811 1 883 2040 False False 0 0 4.0087500478358 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 4 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Val272Ile Rv1129c_p.Val272Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Val272Phe Rv1129c_p.Val272Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1869 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Val317Ala Rv1129c_p.Val317Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Val337Ala Rv1129c_p.Val337Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 2 7 5841 21456 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99967385733588 0.999328137654343 0.999868864001311 0.222222222222222 0.0281449734778982 0.600093573716312 0 0 0.707598226178713 0 0 0.409616397225003 0 0 8.89285479569709 1 883 2040 False False 1.04952674444199 0.106339464971858 5.51346215439655 0 0 0.000631349913487419 0.99967385733588 0.999328137654343 0.999868864001311 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 1 4 2719 9635 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999585019192862 0.998937828281888 0.999886920491758 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.37091971678909 0.582315775027881 122 1102 False False 0 0 0 0 0 0 0 0.885895549834498 0.0179820541723419 8.95537117058933 0 0 0.0013557845626193 0.999585019192862 0.998937828281888 0.999886920491758 5 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Val337Phe Rv1129c_p.Val337Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Val34Leu Rv1129c_p.Val34Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.56487735727821 0.58431003819195 215.5 2040 False False 0 0 5.56487735727821 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Val394Met Rv1129c_p.Val394Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Val414Ile Rv1129c_p.Val414Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Val486Phe Rv1129c_p.Val486Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Val59Ala Rv1129c_p.Val59Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0941866911272879 Inf 0.213982274957884 105.5 2040 False False Inf 0.0941866911272879 Inf 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0908652957857324 Inf 0.220082530949106 80 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Val59Met Rv1129c_p.Val59Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1952 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1065 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Val6Ile Rv1129c_p.Val6Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 3 8 5840 21455 0.000513434879342803 0.000105895133877182 0.00149973424244328 0.99962726552672 0.99926569731444 0.999839066414514 0.272727272727272 0.0602177341729066 0.609742559572421 0 0 0.4592581264399 0 0 0.369416647552819 0 0 3.12138327783248 0.352605108119594 161.5 2040 False False 1.37767551369863 0.235322166271864 5.74292468396216 0 0 0.000631457987209345 0.99962726552672 0.99926569731444 0.999839066414514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 2718 9638 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 0.999896254798215 0.999422105789591 0.999997373402351 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 138.011851332821 1 457.5 1102 False False 0 0 0 0 0 0 0 7.09197939661515 0.368993183584618 417.296682266591 0 0 0.00135628304118183 0.999896254798215 0.999422105789591 0.999997373402351 5 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Val85Met Rv1129c_p.Val85Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Val97Ile Rv1129c_p.Val97Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1885 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv1129c p.Val9Met Rv1129c_p.Val9Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 5842 21461 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99990681638168 0.999663429698698 0.999988714832292 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5709198500876 1 883 2040 False False 1.83678534748373 0.0311281139040964 35.2896458967866 0 0 0.00063124187675269 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 137.961202437293 1 457.5 1102 False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 0 0 0.0013557845626193 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c c.1002C>T Rv2477c_c.1002C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.1030T>C Rv2477c_c.1030T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.1068C>T Rv2477c_c.1068C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 4 5842 21459 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99981363276336 0.999522895233871 0.999949218940757 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.918307086614173 0.0186435710006194 9.27999188457764 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.1071G>T Rv2477c_c.1071G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.1086A>G Rv2477c_c.1086A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 9 11 5834 21452 0.00154030463802841 0.000704559638966774 0.00292195530235611 0.99948749009924 0.999083163687746 0.999744130025508 0.45 0.230577896775924 0.684721866959451 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.00850811855268 1.10130559815913 7.98992652319357 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 9 11 2711 9628 0.00330882352941176 0.00151408667811563 0.00627184495549277 0.998858802780371 0.997959002506684 0.999430185159088 0.45 0.230577896775924 0.684721866959451 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.905737567486 1.06298691134079 7.72262575952966 NA NA NA NA NA NA 16 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.1101C>T Rv2477c_c.1101C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 1 5841 21462 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99995340819084 0.99974043469953 0.999998820398217 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 7.3487416538264 0.382468755528661 432.333734199629 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 2718 9639 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 1 0.999617369678334 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.665658435310444 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.1104C>T Rv2477c_c.1104C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.56487735727821 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 18.8709233025667 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.1116A>G Rv2477c_c.1116A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 19 5843 21444 0 0 0.000631133876986172 0.999114755625961 0.998617924918733 0.999466943572351 0 0 0.176466911806965 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.786724657781743 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 9 2720 9630 0 0 0.00135528645033659 0.99906629318394 0.998228276906464 0.999572963722204 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.79492921444566 NA NA NA NA NA NA 127 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.1122C>T Rv2477c_c.1122C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.1152C>A Rv2477c_c.1152C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.1152C>G Rv2477c_c.1152C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.1158G>A Rv2477c_c.1158G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.1164C>T Rv2477c_c.1164C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 1 5841 21462 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99995340819084 0.99974043469953 0.999998820398217 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 7.3487416538264 0.382468755528661 432.333734199629 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 1 2718 9638 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 0.999896254798215 0.999422105789591 0.999997373402351 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 7.09197939661515 0.368993183584618 417.296682266591 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.1170C>T Rv2477c_c.1170C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.1176C>T Rv2477c_c.1176C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.1212G>A Rv2477c_c.1212G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.89146792489366 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.1221G>A Rv2477c_c.1221G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.1269G>A Rv2477c_c.1269G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.1275C>T Rv2477c_c.1275C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.-12C>A Rv2477c_c.-12C>A 2 upstream_gene_variant 2784054 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c c.1335C>T Rv2477c_c.1335C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.1383C>A Rv2477c_c.1383C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.1401C>T Rv2477c_c.1401C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.1413C>T Rv2477c_c.1413C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.1434G>C Rv2477c_c.1434G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.1443G>C Rv2477c_c.1443G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.1497C>T Rv2477c_c.1497C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.1512C>T Rv2477c_c.1512C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.1521G>T Rv2477c_c.1521G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.1542T>C Rv2477c_c.1542T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.1545C>T Rv2477c_c.1545C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 508 1938 5335 19525 0.0869416395687147 0.079839373269931 0.0944594070189412 0.909705073848017 0.905791781837295 0.913506987033535 0.207686017988552 0.191763278536979 0.224311713774047 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.959326758375623 0.864314280107888 1.06336772728866 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 195 516 2525 9123 0.0716911764705882 0.0622774570448485 0.0820385958506175 0.94646747587924 0.941785318369168 0.950877471217797 0.274261603375527 0.241758832180168 0.308650042359973 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 0 1.36540409854938 1.14514834999156 1.62293419376749 NA NA NA NA NA NA 3618 5) Not assoc w R Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.156C>G Rv2477c_c.156C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.1605C>T Rv2477c_c.1605C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 8 5843 21455 0 0 0.000631133876986172 0.99962726552672 0.99926569731444 0.999839066414514 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.15187999193565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.1620C>T Rv2477c_c.1620C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.1638A>G Rv2477c_c.1638A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.1659C>T Rv2477c_c.1659C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.165C>T Rv2477c_c.165C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 7 5843 21456 0 0 0.000631133876986172 0.99967385733588 0.999328137654343 0.999868864001311 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.5485399472607 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 7 2720 9632 0 0 0.00135528645033659 0.999273783587509 0.99850429270085 0.999707975074577 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.45859411933764 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.1663C>T Rv2477c_c.1663C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.1674C>T Rv2477c_c.1674C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.201C>A Rv2477c_c.201C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.-20C>G Rv2477c_c.-20C>G 2 upstream_gene_variant 2784062 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1987 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c c.219G>A Rv2477c_c.219G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.-25A>C Rv2477c_c.-25A>C 2 upstream_gene_variant 2784067 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c c.270A>G Rv2477c_c.270A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.309C>T Rv2477c_c.309C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.89146792489366 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.312C>T Rv2477c_c.312C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 5 5842 21458 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.9997670409542 0.99945643574724 0.999924354643808 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.73461143444026 0.0155328045999449 6.56618384712436 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 5 2719 9634 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999481273991078 0.998789885214303 0.999831550309162 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.708642883413019 0.0149809692288265 6.33587764491975 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.318C>T Rv2477c_c.318C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 12 5843 21451 0 0 0.000631133876986172 0.99944089829008 0.999023565718772 0.999711071680148 0 0 0.264648469397051 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.32173650369041 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 6 2720 9633 0 0 0.00135528645033659 0.999377528789293 0.998645638320949 0.999771530871485 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.00974784500922 NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.-31A>G Rv2477c_c.-31A>G 2 upstream_gene_variant 2784073 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c c.352C>T Rv2477c_c.352C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.-36A>C Rv2477c_c.-36A>C 2 upstream_gene_variant 2784078 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2028 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1097 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c c.387G>A Rv2477c_c.387G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.393C>T Rv2477c_c.393C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 13 5842 21450 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99939430648092 0.998964468353895 0.999677455549724 0.0714285714285714 0.00180678065912538 0.338684489931821 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.282437521396781 0.00664836898198944 1.88119052490052 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 11 2719 9628 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.998858802780371 0.997959002506684 0.999430185159088 0.0833333333333333 0.00210759323186022 0.384796165150944 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.321909793038884 0.00747960585022801 2.21688560239189 NA NA NA NA NA NA 13 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.396C>T Rv2477c_c.396C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.417G>A Rv2477c_c.417G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.-41T>C Rv2477c_c.-41T>C 2 upstream_gene_variant 2784083 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2024 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c c.429G>A Rv2477c_c.429G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.-44G>A Rv2477c_c.-44G>A 2 upstream_gene_variant 2784086 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2008 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c c.453G>A Rv2477c_c.453G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.483C>T Rv2477c_c.483C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.89146792489366 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.57852451631077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.489C>T Rv2477c_c.489C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.48C>T Rv2477c_c.48C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.492G>A Rv2477c_c.492G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.499C>A Rv2477c_c.499C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.-4C>T Rv2477c_c.-4C>T 2 upstream_gene_variant 2784046 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c c.51T>C Rv2477c_c.51T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.89146792489366 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.57852451631077 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.538C>T Rv2477c_c.538C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.541T>C Rv2477c_c.541T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 18 13 5825 21450 0.00308060927605682 0.00182675474076963 0.00486433743244719 0.99939430648092 0.998964468353895 0.999677455549724 0.580645161290322 0.390759222492092 0.754524049261348 NA NA NA NA NA NA NA NA NA NA NA NA False False 5.09871244635193 2.36006106211703 11.325331614842 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 8 6 2712 9633 0.00294117647058823 0.00127061997302132 0.00578702225151795 0.999377528789293 0.998645638320949 0.999771530871485 0.571428571428571 0.288609400038307 0.823388910017882 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.73598820058997 1.43940103873007 16.5731529188139 NA NA NA NA NA NA 13 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.546G>A Rv2477c_c.546G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.558G>A Rv2477c_c.558G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.-55G>A Rv2477c_c.-55G>A 2 upstream_gene_variant 2784097 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c c.585G>A Rv2477c_c.585G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.612C>T Rv2477c_c.612C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.615C>T Rv2477c_c.615C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.618C>T Rv2477c_c.618C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 5843 21458 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.0087500478358 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 2720 9635 0 0 0.00135528645033659 0.999585019192862 0.998937828281888 0.999886920491758 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 5.36894442066688 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.639C>T Rv2477c_c.639C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.655C>T Rv2477c_c.655C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.69C>T Rv2477c_c.69C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.89146792489366 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.702C>A Rv2477c_c.702C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.708C>A Rv2477c_c.708C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.708C>T Rv2477c_c.708C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.723C>T Rv2477c_c.723C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.89146792489366 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.57852451631077 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.-72T>C Rv2477c_c.-72T>C 2 upstream_gene_variant 2784114 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c c.-73C>G Rv2477c_c.-73C>G 2 upstream_gene_variant 2784115 1 3 0 3 1 3 5842 21460 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99986022457252 0.999591571764338 0.999971174018896 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89298982087011 1 883 2040 False False 1.22446650690402 0.0233203404016305 15.2512395040111 0 0 0.00063124187675269 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c c.753G>A Rv2477c_c.753G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.89146792489366 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 18.8709233025667 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.-75G>A Rv2477c_c.-75G>A 2 upstream_gene_variant 2784117 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1966 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c c.762G>A Rv2477c_c.762G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.-76C>G Rv2477c_c.-76C>G 2 upstream_gene_variant 2784118 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c c.-78delG Rv2477c_c.-78delG 2 upstream_gene_variant 2784119 NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1988 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c c.801C>T Rv2477c_c.801C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.89146792489366 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.813T>G Rv2477c_c.813T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.-81G>A Rv2477c_c.-81G>A 2 upstream_gene_variant 2784123 1 10 0 10 1 11 5842 21452 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99948749009924 0.999083163687746 0.999744130025508 0.0833333333333333 0.00210759323186022 0.384796165150944 0 0 0.30849710781876 0 0 0.284914152918154 0 0 1.63875483870587 0.132895303132456 80 2040 False False 0.333820920606268 0.00775770292617448 2.297821376318 0 0 0.00063124187675269 0.99948749009924 0.999083163687746 0.999744130025508 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 137.896313968788 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 17 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c c.831C>T Rv2477c_c.831C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 5843 21458 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.0087500478358 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 18.8709233025667 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.846C>G Rv2477c_c.846C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.-86G>A Rv2477c_c.-86G>A 2 upstream_gene_variant 2784128 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c c.879G>A Rv2477c_c.879G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 18.8709233025667 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.885A>C Rv2477c_c.885A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.894G>C Rv2477c_c.894G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.897G>A Rv2477c_c.897G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.-8A>G Rv2477c_c.-8A>G 2 upstream_gene_variant 2784050 1 8 0 8 0 12 5843 21451 0 0 0.000631133876986172 0.99944089829008 0.999023565718772 0.999711071680148 0 0 0.264648469397051 0 0 0.369416647552819 0 0 0.264648469397051 0 0 2.15147868397564 0.215630658813126 124 2040 False False 0 0 1.32173650369041 0 0 0.000631133876986172 0.99944089829008 0.999023565718772 0.999711071680148 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 2720 9635 0 0 0.00135528645033659 0.999585019192862 0.998937828281888 0.999886920491758 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 8.57763452631882 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 5.36894442066688 0 0 0.00135528645033659 0.999585019192862 0.998937828281888 0.999886920491758 24 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c c.90G>A Rv2477c_c.90G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.918C>T Rv2477c_c.918C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.948C>G Rv2477c_c.948C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 52 5839 21411 0.000684579839123737 0.000186555462570677 0.00175186028923716 0.997577225923682 0.996824052902906 0.998190043277117 0.0714285714285714 0.0198039315088297 0.172904698139369 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.282068847405377 0.0740801275110512 0.767074890929116 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 6 2719 9633 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999377528789293 0.998645638320949 0.999771530871485 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.590474439132033 0.0128360606385712 4.87020043259644 NA NA NA NA NA NA 52 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.96C>T Rv2477c_c.96C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c c.9G>A Rv2477c_c.9G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 7 5843 21456 0 0 0.000631133876986172 0.99967385733588 0.999328137654343 0.999868864001311 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.5485399472607 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2477c LoF Rv2477c_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2040 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Ala134Val Rv2477c_p.Ala134Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 142.93371627475 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Ala139Val Rv2477c_p.Ala139Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Ala260Arg Rv2477c_p.Ala260Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2003 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1089 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Ala260Val Rv2477c_p.Ala260Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Ala277Thr Rv2477c_p.Ala277Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1977 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Ala286Ser Rv2477c_p.Ala286Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Ala2Val Rv2477c_p.Ala2Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2004 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Ala335Thr Rv2477c_p.Ala335Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89146792489366 1 319.5 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Ala392Thr Rv2477c_p.Ala392Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1993 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Ala392Val Rv2477c_p.Ala392Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Ala424Val Rv2477c_p.Ala424Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 5843 21458 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 5.56461804904681 0.584307247454343 202 2040 False False 0 0 4.0087500478358 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Ala492Asp Rv2477c_p.Ala492Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2000 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Ala52Thr Rv2477c_p.Ala52Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2037 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Ala531Pro Rv2477c_p.Ala531Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Ala531Thr Rv2477c_p.Ala531Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1967 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1072 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Ala65Val Rv2477c_p.Ala65Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 5842 21460 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99986022457252 0.999591571764338 0.999971174018896 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89298982087011 1 883 2040 False False 1.22446650690402 0.0233203404016305 15.2512395040111 0 0 0.00063124187675269 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 3 2719 9636 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999688764394646 0.999090709558603 0.999935811136198 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.58167997356275 1 457.5 1102 False False 0 0 0 0 0 0 0 1.18131666053696 0.0224941657498392 14.7172429763561 0 0 0.0013557845626193 0.999688764394646 0.999090709558603 0.999935811136198 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Ala68Val Rv2477c_p.Ala68Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89146792489366 1 319.5 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.57852451631077 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 8.57852451631077 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Arg149Cys Rv2477c_p.Arg149Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Arg231Leu Rv2477c_p.Arg231Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Arg251Pro Rv2477c_p.Arg251Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1975 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1075 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Arg257Ser Rv2477c_p.Arg257Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1968 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Arg316His Rv2477c_p.Arg316His 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89146792489366 1 319.5 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Arg316Ser Rv2477c_p.Arg316Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 142.964774304408 1 883 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0 0 0.00063124187675269 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1093 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Arg346Cys Rv2477c_p.Arg346Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1978 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 19 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Arg450Lys Rv2477c_p.Arg450Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 142.927071297039 1 883 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Arg450Ser Rv2477c_p.Arg450Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2029 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1098 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Arg450Thr Rv2477c_p.Arg450Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 142.93371627475 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Arg499Cys Rv2477c_p.Arg499Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1989 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Arg504Cys Rv2477c_p.Arg504Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 142.927071297039 1 883 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Arg539Pro Rv2477c_p.Arg539Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1984 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1080 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Arg549Thr Rv2477c_p.Arg549Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Arg553His Rv2477c_p.Arg553His 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Arg86His Rv2477c_p.Arg86His 2 missense_variant (see "Genomic_coordinates" sheet) 1 28 2 26 5 33 5838 21430 0.000855724798904672 0.00027790803803495 0.00199583691247191 0.998462470297721 0.997841408000016 0.998941406264571 0.131578947368421 0.0441374400579144 0.280863845883753 0.0714285714285714 0.00877049670352713 0.23503477317459 0.0571428571428571 0.00699676362830951 0.191571406345239 0.282367512583339 0.0324669558885031 1.12844165487134 0.0672738818329476 64 2040 False False 0.556178433876275 0.169456996601135 1.43457538413392 0.000342465753424657 4.14768826827398e-05 0.00123655079603055 0.998462470297721 0.997841408000016 0.998941406264571 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 1 4 3 6 2717 9633 0.00110294117647058 0.000227510766880298 0.0032198465640147 0.999377528789293 0.998645638320949 0.999771530871485 0.333333333333333 0.0748546314196918 0.700704943791459 0.2 0.00505076337946806 0.716417936118089 0.142857142857142 0.00361029686190058 0.578723197043195 0.886363636363636 0.0179915507377361 8.96010160062481 1 457.5 1102 False False 0 0 0 0 0 0 0 1.77272727272727 0.286666495550917 8.30683786965884 0.000367917586460632 9.31482342481655e-06 0.0020481824615316 0.999377528789293 0.998645638320949 0.999771530871485 56 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Asn240Ser Rv2477c_p.Asn240Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2035 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1101 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Asn80Lys Rv2477c_p.Asn80Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2021 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Asn88Ser Rv2477c_p.Asn88Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Asp133Tyr Rv2477c_p.Asp133Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Asp146Tyr Rv2477c_p.Asp146Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Asp22Asn Rv2477c_p.Asp22Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Asp230Gly Rv2477c_p.Asp230Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Asp259Gly Rv2477c_p.Asp259Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Asp339Glu Rv2477c_p.Asp339Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 25 5842 21438 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.998835204771001 0.998281009378759 0.999246068539694 0.0384615384615384 0.00097328789333503 0.196369646762539 NA NA NA 0 0 0.137185171530712 NA NA NA NA 1980 2040 False False 0.146785347483738 0.00357825563226357 0.897123562298132 0 0 0.00063124187675269 0.998835204771001 0.998281009378759 0.999246068539694 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1077 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Asp374Asn Rv2477c_p.Asp374Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 9 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Asp503Asn Rv2477c_p.Asp503Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Asp503Gly Rv2477c_p.Asp503Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.56487735727821 0.58431003819195 215.5 2040 False False 0 0 5.56487735727821 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Asp516Glu Rv2477c_p.Asp516Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Asp517Ala Rv2477c_p.Asp517Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 1 5841 21462 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99995340819084 0.99974043469953 0.999998820398217 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 2018 2040 False False 7.3487416538264 0.382468755528661 432.333734199629 0 0 0.000631349913487419 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Asp517Asn Rv2477c_p.Asp517Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Asp517Gly Rv2477c_p.Asp517Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Asp543Tyr Rv2477c_p.Asp543Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Asp55Ala Rv2477c_p.Asp55Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 5843 21458 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.0087500478358 0.59157266040946 268 2040 False False 0 0 4.0087500478358 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Asp95Asn Rv2477c_p.Asp95Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Asp95Gly Rv2477c_p.Asp95Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Gln140Glu Rv2477c_p.Gln140Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1979 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Gln196His Rv2477c_p.Gln196His 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 2 2 5841 21461 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99990681638168 0.999663429698698 0.999988714832292 0.5 0.067585986488543 0.932414013511457 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 1.83709981167608 0.0311334422638389 35.2908078710242 0.514340659886591 191 2040 False False 3.67419962335216 0.266252080252227 50.6812073544246 0.000171174255391989 4.33374753915718e-06 0.000953348826018904 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Gln289Pro Rv2477c_p.Gln289Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Gln417His Rv2477c_p.Gln417His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2038 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Gln74His Rv2477c_p.Gln74His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2005 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Glu105Lys Rv2477c_p.Glu105Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1971 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Glu117Ala Rv2477c_p.Glu117Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Glu120Asp Rv2477c_p.Glu120Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Glu127Asp Rv2477c_p.Glu127Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Glu128Asp Rv2477c_p.Glu128Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Glu224Lys Rv2477c_p.Glu224Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.56487735727821 0.58431003819195 215.5 2040 False False 0 0 5.56487735727821 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Glu238Val Rv2477c_p.Glu238Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 142.964774304408 1 883 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0 0 0.00063124187675269 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Glu250Ala Rv2477c_p.Glu250Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Glu268Lys Rv2477c_p.Glu268Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Glu308Lys Rv2477c_p.Glu308Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5841 21463 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 1 0.999828143201531 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2025 2040 False False Inf 0.689929368506768 Inf 0 0 0.000631349913487419 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 2718 9639 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 1 0.999617369678334 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1095 1102 False False 0 0 0 0 0 0 0 Inf 0.665658435310444 Inf 0 0 0.00135628304118183 1 0.999617369678334 1 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Glu476Ala Rv2477c_p.Glu476Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Glu538_Leu540delinsVal Rv2477c_p.Glu538_Leu540delinsVal 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 142.93371627475 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Glu81Lys Rv2477c_p.Glu81Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Glu90Asp Rv2477c_p.Glu90Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Glu91Asp Rv2477c_p.Glu91Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1995 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1085 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Glu91Gly Rv2477c_p.Glu91Gly 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2012 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Gly123Asp Rv2477c_p.Gly123Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Gly162Ser Rv2477c_p.Gly162Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2009 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Gly207Asp Rv2477c_p.Gly207Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Gly207Cys Rv2477c_p.Gly207Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Gly207Ser Rv2477c_p.Gly207Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Gly256Ser Rv2477c_p.Gly256Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Gly314Arg Rv2477c_p.Gly314Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2036 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Gly395Asp Rv2477c_p.Gly395Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1972 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Gly409Ser Rv2477c_p.Gly409Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5841 21463 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 1 0.999828143201531 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2022 2040 False False Inf 0.689929368506768 Inf 0 0 0.000631349913487419 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 2718 9639 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 1 0.999617369678334 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1094 1102 False False 0 0 0 0 0 0 0 Inf 0.665658435310444 Inf 0 0 0.00135628304118183 1 0.999617369678334 1 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Gly41Glu Rv2477c_p.Gly41Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 235 4 231 34 238 5809 21225 0.00581892863255177 0.00403304404399734 0.00812196208487503 0.988911149419932 0.987418689330218 0.990268876439312 0.125 0.0881414664304845 0.17027422897443 0.0170212765957446 0.00465670659292903 0.0430053788169791 0.0165289256198347 0.00452147162820293 0.0417775176805453 0.0632694900210823 0.0170787122112266 0.164292313903173 4.0332037310257e-19 9 2040 True False 0.521973292673929 0.352774124487581 0.750864343894836 0.000688112850507483 0.000187518404901793 0.00176089651661444 0.988911149419932 0.987418689330218 0.990268876439312 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 29 0 29 12 32 2708 9607 0.00441176470588235 0.00228163789982352 0.00769377081358202 0.996680153542898 0.995316571232874 0.997728152901178 0.272727272727272 0.149576843765308 0.4278964124555 0 0 0.119444869069502 0 0 0.108881160679352 0 0 0.481657585684995 0.00116211578715526 20 1102 False False 0 0 0 0 0 0 0 1.33036373707533 0.623069424919743 2.6578897780945 0 0 0.00136128806140643 0.996680153542898 0.995316571232874 0.997728152901178 122 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Gly433Val Rv2477c_p.Gly433Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Gly441Ala Rv2477c_p.Gly441Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 14 0 14 0 16 5843 21447 0 0 0.000631133876986172 0.99925453105344 0.998789686679379 0.999573841954248 0 0 0.205907214207822 0 0 0.231635761650116 0 0 0.205907214207822 0 0 1.1069565696621 0.0511319636542069 58 2040 False False 0 0 0.952125276634789 0 0 0.000631133876986172 0.99925453105344 0.998789686679379 0.999573841954248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 12 0 12 0 14 2720 9625 0 0 0.00135528645033659 0.998547567175018 0.997564264113055 0.999205721130751 0 0 0.231635761650116 0 0 0.264648469397051 0 0 0.231635761650116 0 0 1.27453058483992 0.0809942952923791 43 1102 False False 0 0 0 0 0 0 0 0 0 1.06763707910471 0 0 0.00135528645033659 0.998547567175018 0.997564264113055 0.999205721130751 19 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Gly460Ser Rv2477c_p.Gly460Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Gly527Ser Rv2477c_p.Gly527Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2015 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1091 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Gly530Asp Rv2477c_p.Gly530Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Gly558Asp Rv2477c_p.Gly558Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5841 21463 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 1 0.999828143201531 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2032 2040 False False Inf 0.689929368506768 Inf 0 0 0.000631349913487419 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Gly87Arg Rv2477c_p.Gly87Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2019 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Gly87Ser Rv2477c_p.Gly87Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1990 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.His189Tyr Rv2477c_p.His189Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 4 13 5839 21450 0.000684579839123737 0.000186555462570677 0.00175186028923716 0.99939430648092 0.998964468353895 0.999677455549724 0.235294117647058 0.0681077404373566 0.49899327320458 NA NA NA 0 0 0.24705263800047 NA NA NA NA 1994 2040 False False 1.13033053605069 0.268378387504693 3.66040055612054 0 0 0.000631566097937464 0.99939430648092 0.998964468353895 0.999677455549724 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 10 2719 9629 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.998962547982155 0.998092919138308 0.999502392880449 0.0909090909090909 0.00229897221381426 0.412779916988382 NA NA NA 0 0 0.30849710781876 NA NA NA NA 1084 1102 False False 0 0 0 0 0 0 0 0.354137550570062 0.00816086917678301 2.49148327858236 0 0 0.0013557845626193 0.998962547982155 0.998092919138308 0.999502392880449 11 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.His201Asp Rv2477c_p.His201Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2026 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.His326Arg Rv2477c_p.His326Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Ile20Val Rv2477c_p.Ile20Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Ile311Met Rv2477c_p.Ile311Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1998 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1087 1102 False False 0 0 0 0 0 0 0 0 0 8.57852451631077 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Ile396Val Rv2477c_p.Ile396Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1985 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1081 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Ile413Val Rv2477c_p.Ile413Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Ile464Val Rv2477c_p.Ile464Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2016 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Leu109Phe Rv2477c_p.Leu109Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Leu148Pro Rv2477c_p.Leu148Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Leu198Val Rv2477c_p.Leu198Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 19.5666713375759 1 883 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 137.896313968788 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Leu227Gln Rv2477c_p.Leu227Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 5 5843 21458 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 2030 2040 False False 0 0 4.0087500478358 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 2720 9634 0 0 0.00135528645033659 0.999481273991078 0.998789885214303 0.999831550309162 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1099 1102 False False 0 0 0 0 0 0 0 0 0 3.8675231049739 0 0 0.00135528645033659 0.999481273991078 0.998789885214303 0.999831550309162 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Leu288Val Rv2477c_p.Leu288Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 18 5841 21445 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99916134743512 0.998674889990656 0.999502887997069 0.1 0.0123485271702948 0.316982714019082 NA NA NA 0 0 0.185301968137852 NA NA NA NA 2006 2040 False False 0.407940040708402 0.0458947155795477 1.70471612369336 0 0 0.000631349913487419 0.99916134743512 0.998674889990656 0.999502887997069 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 8 2720 9631 0 0 0.00135528645033659 0.999170038385724 0.99836530325407 0.99964161554927 0 0 0.369416647552819 0 0 0.707598226178713 0 0 0.369416647552819 0 0 8.57407456467642 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 2.07582396316403 0 0 0.00135528645033659 0.999170038385724 0.99836530325407 0.99964161554927 22 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Leu327His Rv2477c_p.Leu327His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2020 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Leu327Phe Rv2477c_p.Leu327Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 1 4 2 4 5841 21459 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99981363276336 0.999522895233871 0.999949218940757 0.333333333333333 0.0432718682927417 0.777221904496487 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 0.918464304057524 0.0186467623313763 9.28157946556268 1 883 2040 False False 1.83692860811504 0.166109303397098 12.8208569329986 0.000171174255391989 4.33374753915718e-06 0.000953348826018904 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Leu370Arg Rv2477c_p.Leu370Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Leu455Ser Rv2477c_p.Leu455Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Leu473Arg Rv2477c_p.Leu473Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Leu481Val Rv2477c_p.Leu481Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Leu486Arg Rv2477c_p.Leu486Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Leu540Phe Rv2477c_p.Leu540Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 19.5657623867404 1 883 2040 False False 0 0 5.56487735727821 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Leu54Ser Rv2477c_p.Leu54Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1981 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1078 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Leu73Pro Rv2477c_p.Leu73Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2001 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Lys278Asn Rv2477c_p.Lys278Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Lys303Glu Rv2477c_p.Lys303Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Lys33Asn Rv2477c_p.Lys33Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 0 8 5843 21455 0 0 0.000631133876986172 0.99962726552672 0.99926569731444 0.999839066414514 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 2.15187999193565 0.215644316894169 127.5 2040 False False 0 0 2.15187999193565 0 0 0.000631133876986172 0.99962726552672 0.99926569731444 0.999839066414514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 2720 9634 0 0 0.00135528645033659 0.999481273991078 0.998789885214303 0.999831550309162 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 3.8675231049739 0.592777991359257 136 1102 False False 0 0 0 0 0 0 0 0 0 3.8675231049739 0 0 0.00135528645033659 0.999481273991078 0.998789885214303 0.999831550309162 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Lys379Asn Rv2477c_p.Lys379Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 7 5843 21456 0 0 0.000631133876986172 0.99967385733588 0.999328137654343 0.999868864001311 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 2.5485399472607 0.358203244449244 169.5 2040 False False 0 0 2.5485399472607 0 0 0.000631133876986172 0.99967385733588 0.999328137654343 0.999868864001311 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.57852451631077 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 8.57852451631077 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Lys385Thr Rv2477c_p.Lys385Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Lys458Asn Rv2477c_p.Lys458Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1996 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1086 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Lys458Glu Rv2477c_p.Lys458Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1991 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1083 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Met51Val Rv2477c_p.Met51Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Met93Ile Rv2477c_p.Met93Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1969 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1073 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Phe306Ser Rv2477c_p.Phe306Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Phe429Leu Rv2477c_p.Phe429Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Phe4Ser Rv2477c_p.Phe4Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 19.5666713375759 1 883 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Pro186Leu Rv2477c_p.Pro186Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Pro186Ser Rv2477c_p.Pro186Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1973 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Pro236His Rv2477c_p.Pro236His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2010 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Pro312Gln Rv2477c_p.Pro312Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Pro355Ser Rv2477c_p.Pro355Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1992 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Pro39Ser Rv2477c_p.Pro39Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 12 0 12 0 17 5843 21446 0 0 0.000631133876986172 0.99920793924428 0.99873213590018 0.999538529867378 0 0 0.195064322969093 0 0 0.264648469397051 0 0 0.195064322969093 0 0 1.32142845758717 0.0822787162874409 67 2040 False False 0 0 0.889778498175186 0 0 0.000631133876986172 0.99920793924428 0.99873213590018 0.999538529867378 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 12 0 12 0 16 2720 9623 0 0 0.00135528645033659 0.998340076771449 0.997305784636461 0.999050922126668 0 0 0.205907214207822 0 0 0.264648469397051 0 0 0.205907214207822 0 0 1.27426581115931 0.0809894981315769 42 1102 False False 0 0 0 0 0 0 0 0 0 0.918144673960002 0 0 0.00135528645033659 0.998340076771449 0.997305784636461 0.999050922126668 6 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Pro421Leu Rv2477c_p.Pro421Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2017 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1092 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Pro434Gln Rv2477c_p.Pro434Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 8 0 5835 21463 0.00136915967824747 0.00059128544285425 0.00269599843431209 1 0.999828143201531 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 1974 2040 False False Inf 6.27539831235533 Inf 0 0 0.00063199891129229 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 5 0 2715 9639 0.00183823529411764 0.000597130943349739 0.00428457163587036 1 0.999617369678334 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 1074 1102 False False 0 0 0 0 0 0 0 Inf 3.25048589412313 Inf 0 0 0.00135778067859282 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Pro489Leu Rv2477c_p.Pro489Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1982 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Pro489Ser Rv2477c_p.Pro489Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2011 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1090 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Pro547Leu Rv2477c_p.Pro547Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0941866911272879 Inf 0.213982274957884 105.5 2040 False False Inf 0.0941866911272879 Inf 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Pro78Ala Rv2477c_p.Pro78Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Pro78Ser Rv2477c_p.Pro78Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Ser176Pro Rv2477c_p.Ser176Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2013 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Ser242Pro Rv2477c_p.Ser242Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Ser27Gly Rv2477c_p.Ser27Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 7 5843 21456 0 0 0.000631133876986172 0.99967385733588 0.999328137654343 0.999868864001311 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 2007 2040 False False 0 0 2.5485399472607 0 0 0.000631133876986172 0.99967385733588 0.999328137654343 0.999868864001311 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Ser341Ala Rv2477c_p.Ser341Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Ser341Trp Rv2477c_p.Ser341Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Ser375Gly Rv2477c_p.Ser375Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Ser377Cys Rv2477c_p.Ser377Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2014 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Ser407Ala Rv2477c_p.Ser407Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2039 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1102 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Ser427Leu Rv2477c_p.Ser427Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Ser480Leu Rv2477c_p.Ser480Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2031 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Ter559Glnext*? Rv2477c_p.Ter559Glnext*? 2 stop_lost (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Thr187Ala Rv2477c_p.Thr187Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1970 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Thr267Ile Rv2477c_p.Thr267Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Thr362Ala Rv2477c_p.Thr362Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1986 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1082 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Thr372Lys Rv2477c_p.Thr372Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 9 5841 21454 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99958067371756 0.999204138016772 0.999808239967157 0.181818181818181 0.0228311982999596 0.517755852360172 NA NA NA 0 0 0.336267116879942 NA NA NA NA 2033 2040 False False 0.816222488538872 0.0857956692845824 3.94510286595224 0 0 0.000631349913487419 0.99958067371756 0.999204138016772 0.999808239967157 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 2 2719 9637 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999792509596431 0.999250676427901 0.999974870961701 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1100 1102 False False 0 0 0 0 0 0 0 1.77215888194189 0.0300270423699391 34.0580978516331 0 0 0.0013557845626193 0.999792509596431 0.999250676427901 0.999974870961701 71 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Thr505Arg Rv2477c_p.Thr505Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Thr505Met Rv2477c_p.Thr505Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1997 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Thr551Ile Rv2477c_p.Thr551Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Thr7Met Rv2477c_p.Thr7Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 5842 21461 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99990681638168 0.999663429698698 0.999988714832292 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 142.958128195713 1 883 2040 False False 1.83678534748373 0.0311281139040964 35.2896458967866 0 0 0.00063124187675269 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Trp524Arg Rv2477c_p.Trp524Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Tyr114Asp Rv2477c_p.Tyr114Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Tyr114Cys Rv2477c_p.Tyr114Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Tyr114Ser Rv2477c_p.Tyr114Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Val168Ala Rv2477c_p.Val168Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1976 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1076 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Val195Met Rv2477c_p.Val195Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Val313Leu Rv2477c_p.Val313Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Val313Phe Rv2477c_p.Val313Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 5841 21462 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99995340819084 0.99974043469953 0.999998820398217 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 142.989195698265 1 319.5 2040 False False 7.3487416538264 0.382468755528661 432.333734199629 0 0 0.000631349913487419 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Val320Met Rv2477c_p.Val320Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 5843 21457 0 0 0.000631133876986172 0.99972044914504 0.999391635540124 0.999897403075094 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.1200699364824 0.35257212959262 148.5 2040 False False 0 0 3.1200699364824 0 0 0.000631133876986172 0.99972044914504 0.999391635540124 0.999897403075094 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.57852451631077 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 8.57852451631077 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Val322Ile Rv2477c_p.Val322Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 5842 21461 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99990681638168 0.999663429698698 0.999988714832292 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5709198500876 1 883 2040 False False 1.83678534748373 0.0311281139040964 35.2896458967866 0 0 0.00063124187675269 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 137.961202437293 1 457.5 1102 False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 0 0 0.0013557845626193 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Val324Ala Rv2477c_p.Val324Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Val324Ile Rv2477c_p.Val324Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2002 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1088 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Val352Ala Rv2477c_p.Val352Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Val368Phe Rv2477c_p.Val368Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 5842 21461 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99990681638168 0.999663429698698 0.999988714832292 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5709198500876 1 883 2040 False False 1.83678534748373 0.0311281139040964 35.2896458967866 0 0 0.00063124187675269 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 137.961202437293 1 457.5 1102 False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 0 0 0.0013557845626193 0.999896254798215 0.999422105789591 0.999997373402351 5 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Val384Leu Rv2477c_p.Val384Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Val389_Asp390insGly Rv2477c_p.Val389_Asp390insGly 2 inframe_insertion (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1983 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1079 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Val389Ala Rv2477c_p.Val389Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Val405Gly Rv2477c_p.Val405Gly 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 2 5839 21461 0.000684579839123737 0.000186555462570677 0.00175186028923716 0.99990681638168 0.999663429698698 0.999988714832292 0.666666666666666 0.222778095503512 0.956728131707258 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2023 2040 False False 7.35091625278301 1.05312258017444 81.088172349177 0 0 0.000631566097937464 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Val406Phe Rv2477c_p.Val406Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1999 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Val420Ala Rv2477c_p.Val420Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Val426Ala Rv2477c_p.Val426Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 142.93371627475 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 137.896313968788 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Val426Met Rv2477c_p.Val426Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 1 8 5842 21455 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99962726552672 0.99926569731444 0.999839066414514 0.111111111111111 0.00280913674659921 0.482496514917337 0 0 0.369416647552819 0 0 0.369416647552819 0 0 2.1522485685766 0.215656865655095 131.5 2040 False False 0.45906795617939 0.0103475211102756 3.425357676166 0 0 0.00063124187675269 0.99962726552672 0.99926569731444 0.999839066414514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 1 6 2719 9633 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999377528789293 0.998645638320949 0.999771530871485 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.0108549377958 0.350029495956578 96 1102 False False 0 0 0 0 0 0 0 0.590474439132033 0.0128360606385712 4.87020043259644 0 0 0.0013557845626193 0.999377528789293 0.998645638320949 0.999771530871485 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Val475Gly Rv2477c_p.Val475Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Val493Met Rv2477c_p.Val493Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 142.93371627475 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Val550fs Rv2477c_p.Val550fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2034 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Val70Ala Rv2477c_p.Val70Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 3 5842 21460 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99986022457252 0.999591571764338 0.999971174018896 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2027 2040 False False 1.22446650690402 0.0233203404016305 15.2512395040111 0 0 0.00063124187675269 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1096 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 4 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Val70Met Rv2477c_p.Val70Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Val85Ile Rv2477c_p.Val85Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 14 1 13 20 33 5823 21430 0.00342289919561868 0.00209201097268901 0.00528146372285452 0.998462470297721 0.997841408000016 0.998941406264571 0.377358490566037 0.247872198464912 0.521060715081297 0.0714285714285714 0.00180678065912538 0.338684489931821 0.0294117647058823 0.00074436423469026 0.153267669560317 0.28309488896815 0.00666382922463872 1.88557055229078 0.326795566320081 142 2040 False False 2.23044457974906 1.21184917913332 4.00723402503244 0.000171703296703296 4.34714164735598e-06 0.000956294146097759 0.998462470297721 0.997841408000016 0.998941406264571 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 1 3 15 3 2705 9636 0.00551470588235294 0.00308972573905283 0.00907938157352261 0.999688764394646 0.999090709558603 0.999935811136198 0.833333333333333 0.585822508605226 0.964214916878425 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 1.18743068391866 0.0226105446668098 14.7934376732251 1 147 1102 False False 0 0 0 0 0 0 0 17.81146025878 5.03185736882552 96.0891194743012 0.000369549150036954 9.35613065252976e-06 0.00205725763905087 0.999688764394646 0.999090709558603 0.999935811136198 84 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2477c p.Val89Met Rv2477c_p.Val89Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 142.964774304408 1 883 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0 0 0.00063124187675269 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c c.1018C>T Rv2752c_c.1018C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1026C>G Rv2752c_c.1026C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1029C>G Rv2752c_c.1029C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1050A>C Rv2752c_c.1050A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1050A>T Rv2752c_c.1050A>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.105A>G Rv2752c_c.105A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1063C>T Rv2752c_c.1063C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 7 35 5836 21428 0.00119801471846654 0.000481795418920789 0.00246680058103687 0.998369286679401 0.997732795230871 0.998863893692721 0.166666666666666 0.069740663655675 0.313640866880671 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.734338588074023 0.275124853695807 1.67899345343175 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 5 2719 9634 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999481273991078 0.998789885214303 0.999831550309162 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.708642883413019 0.0149809692288265 6.33587764491975 NA NA NA NA NA NA 35 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1068C>T Rv2752c_c.1068C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1074C>T Rv2752c_c.1074C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 9 5843 21454 0 0 0.000631133876986172 0.99958067371756 0.999204138016772 0.999808239967157 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.86084922251217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.-10T>C Rv2752c_c.-10T>C 2 upstream_gene_variant 3066201 1 1 0 1 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 142.964774304408 1 883 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0 0 0.00063124187675269 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 137.961202437293 1 457.5 1102 False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 0 0 0.0013557845626193 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c c.1104A>G Rv2752c_c.1104A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1107G>A Rv2752c_c.1107G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1122C>G Rv2752c_c.1122C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1134C>T Rv2752c_c.1134C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.89146792489366 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 18.8709233025667 NA NA NA NA NA NA 15 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1137T>C Rv2752c_c.1137T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 8 5843 21455 0 0 0.000631133876986172 0.99962726552672 0.99926569731444 0.999839066414514 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.15187999193565 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1141C>T Rv2752c_c.1141C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1155C>T Rv2752c_c.1155C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1158C>T Rv2752c_c.1158C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1167G>A Rv2752c_c.1167G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 10 5840 21453 0.000513434879342803 0.000105895133877182 0.00149973424244328 0.9995340819084 0.999143327515781 0.999776552276323 0.23076923076923 0.0503810734911515 0.53813153923404 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.10203767123287 0.194826487732604 4.28214028428906 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 18.8709233025667 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1167G>T Rv2752c_c.1167G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1221C>T Rv2752c_c.1221C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1225C>T Rv2752c_c.1225C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1239C>T Rv2752c_c.1239C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1248G>A Rv2752c_c.1248G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1275C>T Rv2752c_c.1275C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1278T>C Rv2752c_c.1278T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1290C>T Rv2752c_c.1290C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1311T>C Rv2752c_c.1311T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1314C>T Rv2752c_c.1314C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1317C>A Rv2752c_c.1317C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1317C>G Rv2752c_c.1317C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 6 14 5837 21449 0.0010268697586856 0.000376933373413978 0.00223371319186393 0.99934771467176 0.998905818000026 0.999643345117175 0.3 0.118931590405727 0.542789182276289 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.57485498910888 0.495808664270027 4.36478056124371 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 6 12 2714 9627 0.00220588235294117 0.000809936709089192 0.00479504888600855 0.998755057578587 0.997826347023296 0.999356559855396 0.333333333333333 0.133427402506123 0.590074761827925 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.77358142962417 0.545608704324614 5.11139424192324 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1320T>C Rv2752c_c.1320T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.135C>T Rv2752c_c.135C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1368C>T Rv2752c_c.1368C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1380C>T Rv2752c_c.1380C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1383C>A Rv2752c_c.1383C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1419C>A Rv2752c_c.1419C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1438A>C Rv2752c_c.1438A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1467G>A Rv2752c_c.1467G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1467G>T Rv2752c_c.1467G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 18.8709233025667 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1470A>G Rv2752c_c.1470A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.89146792489366 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1473T>C Rv2752c_c.1473T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1485G>A Rv2752c_c.1485G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1503C>T Rv2752c_c.1503C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 6 5842 21457 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99972044914504 0.999391635540124 0.999897403075094 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.612147666324318 0.0133096260827154 5.04744841661085 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 18.8709233025667 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1509G>A Rv2752c_c.1509G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1509G>T Rv2752c_c.1509G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.89146792489366 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1521C>T Rv2752c_c.1521C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1527C>T Rv2752c_c.1527C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1539A>C Rv2752c_c.1539A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1560C>T Rv2752c_c.1560C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 67 950 5776 20513 0.0114667123053226 0.00889728897188123 0.0145397404591057 0.955737781298047 0.952900473010784 0.958450810002358 0.0658800393313667 0.0514173522152345 0.0829136412180082 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.250468544977401 0.192180530961513 0.321713969581903 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 26 308 2694 9331 0.00955882352941176 0.00625337383872176 0.0139747242923583 0.968046477850399 0.964339066425702 0.97146738670141 0.0778443113772455 0.0514786726397854 0.111980673262618 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 0 0.292383748397111 0.18754605858624 0.437997017745017 NA NA NA NA NA NA 1532 5) Not assoc w R Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1572C>A Rv2752c_c.1572C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1596G>A Rv2752c_c.1596G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.56487735727821 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.57852451631077 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1599G>A Rv2752c_c.1599G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1602C>T Rv2752c_c.1602C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1608G>T Rv2752c_c.1608G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1614C>T Rv2752c_c.1614C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1623G>A Rv2752c_c.1623G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.162G>A Rv2752c_c.162G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1638C>T Rv2752c_c.1638C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.67374186922286 0.0467931454016956 287.712465214691 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.1662G>T Rv2752c_c.1662G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.-17C>G Rv2752c_c.-17C>G 2 upstream_gene_variant 3066208 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c c.183G>A Rv2752c_c.183G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 7 5841 21456 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99967385733588 0.999328137654343 0.999868864001311 0.222222222222222 0.0281449734778982 0.600093573716312 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.04952674444199 0.106339464971858 5.51346215439655 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 4 2718 9635 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 0.999585019192862 0.998937828281888 0.999886920491758 0.333333333333333 0.0432718682927417 0.777221904496487 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.77244297277409 0.160228512115282 12.3744222113045 NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.189C>T Rv2752c_c.189C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.201C>T Rv2752c_c.201C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.207C>T Rv2752c_c.207C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.229C>T Rv2752c_c.229C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.231G>C Rv2752c_c.231G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.234G>A Rv2752c_c.234G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 17 5841 21446 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99920793924428 0.99873213590018 0.999538529867378 0.105263157894736 0.0130121643717774 0.331376664456765 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.431956655286665 0.0483961600105398 1.82051804673259 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 16 2719 9623 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.998340076771449 0.997305784636461 0.999050922126668 0.0588235294117647 0.00148817439126663 0.28688939666722 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.221198050753953 0.00527647421045524 1.42518759314814 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.240C>T Rv2752c_c.240C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.243C>T Rv2752c_c.243C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.258C>T Rv2752c_c.258C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.-26A>G Rv2752c_c.-26A>G 2 upstream_gene_variant 3066217 NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1753 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c c.282C>G Rv2752c_c.282C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.306C>G Rv2752c_c.306C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.-30T>C Rv2752c_c.-30T>C 2 upstream_gene_variant 3066221 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1723 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c c.312C>T Rv2752c_c.312C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.67374186922286 0.0467931454016956 287.712465214691 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.-31A>G Rv2752c_c.-31A>G 2 upstream_gene_variant 3066222 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c c.330T>G Rv2752c_c.330T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.333G>C Rv2752c_c.333G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.-34G>C Rv2752c_c.-34G>C 2 upstream_gene_variant 3066225 1 0 0 0 2 6 5841 21457 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99972044914504 0.999391635540124 0.999897403075094 0.25 0.0318540262499442 0.650855794412824 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1717 2040 False False 1.22450493636934 0.120807800831081 6.84885887832521 0 0 0.000631349913487419 0.99972044914504 0.999391635540124 0.999897403075094 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 6 2718 9633 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 0.999377528789293 0.998645638320949 0.999771530871485 0.25 0.0318540262499442 0.650855794412824 NA NA NA 0 0 0.4592581264399 NA NA NA NA 937 1102 False False 0 0 0 0 0 0 0 1.18138337012509 0.116521123502191 6.61177469050637 0 0 0.00135628304118183 0.999377528789293 0.998645638320949 0.999771530871485 11 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c c.360C>T Rv2752c_c.360C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 5843 21457 0 0 0.000631133876986172 0.99972044914504 0.999391635540124 0.999897403075094 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.1200699364824 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 2720 9635 0 0 0.00135528645033659 0.999585019192862 0.998937828281888 0.999886920491758 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 5.36894442066688 NA NA NA NA NA NA 11 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.366A>C Rv2752c_c.366A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.378C>A Rv2752c_c.378C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 1 5841 21462 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99995340819084 0.99974043469953 0.999998820398217 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 7.3487416538264 0.382468755528661 432.333734199629 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.387C>T Rv2752c_c.387C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 5841 21463 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 1 0.999828143201531 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.689929368506768 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 2718 9639 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 1 0.999617369678334 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.665658435310444 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.-39_-32delCTTCGGTG Rv2752c_c.-39_-32delCTTCGGTG 2 upstream_gene_variant 3066222 1 2 1 1 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 3.67374186922286 0.0467931454016956 287.712465214691 0.382182295738733 180 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c c.-3G>T Rv2752c_c.-3G>T 2 upstream_gene_variant 3066194 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c c.450T>G Rv2752c_c.450T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.-46C>T Rv2752c_c.-46C>T 2 upstream_gene_variant 3066237 1 0 0 0 11 2 5832 21461 0.00188259455759027 0.000940147291275547 0.00336597924963922 0.99990681638168 0.999663429698698 0.999988714832292 0.846153846153846 0.545528944323442 0.980793328017471 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1745 2040 False False 20.2392832647462 4.41470747463093 187.563440708382 0 0 0.000632323910806262 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 11 2 2709 9637 0.00404411764705882 0.00202048490520436 0.0072244966118925 0.999792509596431 0.999250676427901 0.999974870961701 0.846153846153846 0.545528944323442 0.980793328017471 NA NA NA 0 0 0.841886116991581 NA NA NA NA 953 1102 False False 0 0 0 0 0 0 0 19.5657069029162 4.26506801570532 181.398542642728 0 0 0.00136078589771868 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c c.477T>C Rv2752c_c.477T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 14 5842 21449 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99934771467176 0.998905818000026 0.999643345117175 0.0666666666666666 0.0016864302413527 0.319484566578303 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.262251185993055 0.00620473568659099 1.72443749532806 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 18.8709233025667 NA NA NA NA NA NA 26 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.-47C>T Rv2752c_c.-47C>T 2 upstream_gene_variant 3066238 1 0 0 0 11 2 5832 21461 0.00188259455759027 0.000940147291275547 0.00336597924963922 0.99990681638168 0.999663429698698 0.999988714832292 0.846153846153846 0.545528944323442 0.980793328017471 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1626 2040 False False 20.2392832647462 4.41470747463093 187.563440708382 0 0 0.000632323910806262 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 11 2 2709 9637 0.00404411764705882 0.00202048490520436 0.0072244966118925 0.999792509596431 0.999250676427901 0.999974870961701 0.846153846153846 0.545528944323442 0.980793328017471 NA NA NA 0 0 0.841886116991581 NA NA NA NA 882 1102 False False 0 0 0 0 0 0 0 19.5657069029162 4.26506801570532 181.398542642728 0 0 0.00136078589771868 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c c.480C>T Rv2752c_c.480C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.496C>T Rv2752c_c.496C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.513C>T Rv2752c_c.513C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.537C>T Rv2752c_c.537C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.549C>T Rv2752c_c.549C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.89146792489366 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.561C>A Rv2752c_c.561C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.576C>G Rv2752c_c.576C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.576C>T Rv2752c_c.576C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 9 14 5834 21449 0.00154030463802841 0.000704559638966774 0.00292195530235611 0.99934771467176 0.998905818000026 0.999643345117175 0.391304347826087 0.197076423969014 0.61458104261115 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.36349723296929 0.901882018158228 5.86586637074143 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 7 0 2713 9639 0.0025735294117647 0.0010352988504908 0.00529522151968195 1 0.999617369678334 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 5.11563245903239 Inf NA NA NA NA NA NA 45 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.585C>T Rv2752c_c.585C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 5842 21461 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99990681638168 0.999663429698698 0.999988714832292 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.83678534748373 0.0311281139040964 35.2896458967866 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.598C>T Rv2752c_c.598C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.56487735727821 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.-5C>G Rv2752c_c.-5C>G 2 upstream_gene_variant 3066196 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c c.603C>T Rv2752c_c.603C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 3 5842 21460 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99986022457252 0.999591571764338 0.999971174018896 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.22446650690402 0.0233203404016305 15.2512395040111 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.606C>T Rv2752c_c.606C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.633C>A Rv2752c_c.633C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.66C>T Rv2752c_c.66C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.675C>T Rv2752c_c.675C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 8 77 5835 21386 0.00136915967824747 0.00059128544285425 0.00269599843431209 0.996412430694684 0.99551816444126 0.997167740535228 0.0941176470588235 0.041515136680078 0.177052222448859 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.380792129892387 0.158662029619025 0.789157128372166 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 10 2717 9629 0.00110294117647058 0.000227510766880298 0.0032198465640147 0.998962547982155 0.998092919138308 0.999502392880449 0.23076923076923 0.0503810734911515 0.53813153923404 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.0631947000368 0.187888245378151 4.13337186240759 NA NA NA NA NA NA 120 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.690C>T Rv2752c_c.690C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.699G>A Rv2752c_c.699G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.708G>A Rv2752c_c.708G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.711T>C Rv2752c_c.711T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 18.8709233025667 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.717C>G Rv2752c_c.717C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.720C>T Rv2752c_c.720C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.732G>A Rv2752c_c.732G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.753C>T Rv2752c_c.753C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 18.8709233025667 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.756A>C Rv2752c_c.756A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.771G>A Rv2752c_c.771G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.786C>T Rv2752c_c.786C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.795G>T Rv2752c_c.795G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.89146792489366 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.804C>T Rv2752c_c.804C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.819A>G Rv2752c_c.819A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 7 5843 21456 0 0 0.000631133876986172 0.99967385733588 0.999328137654343 0.999868864001311 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.5485399472607 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.57852451631077 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.835C>T Rv2752c_c.835C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.840A>T Rv2752c_c.840A>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.843G>A Rv2752c_c.843G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.846T>G Rv2752c_c.846T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.858C>T Rv2752c_c.858C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.861C>T Rv2752c_c.861C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.870C>T Rv2752c_c.870C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.891C>G Rv2752c_c.891C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.-8delG Rv2752c_c.-8delG 2 upstream_gene_variant 3066198 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c c.918C>A Rv2752c_c.918C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 19.5675802888319 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.-937A>T Rv2752c_c.-937A>T 2 upstream_gene_variant 3067128 1 3 0 3 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89146792489366 1 319.5 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c c.942G>A Rv2752c_c.942G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0941866911272879 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.-944C>T Rv2752c_c.-944C>T 2 upstream_gene_variant 3067135 1 1 0 1 4 20 5839 21443 0.000684579839123737 0.000186555462570677 0.00175186028923716 0.999068163816801 0.998561219655491 0.999430720271997 0.166666666666666 0.0473536266072571 0.373841713488682 0 0 0.975 0 0 0.168433470983085 0 0 142.911722633697 1 883 2040 False False 0.734475081349546 0.182484421965991 2.19375637401862 0 0 0.000631566097937464 0.999068163816801 0.998561219655491 0.999430720271997 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 16 2719 9623 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.998340076771449 0.997305784636461 0.999050922126668 0.0588235294117647 0.00148817439126663 0.28688939666722 0 0 0.975 0 0 0.205907214207822 0 0 137.746972326754 1 457.5 1102 False False 0 0 0 0 0 0 0 0.221198050753953 0.00527647421045524 1.42518759314814 0 0 0.0013557845626193 0.998340076771449 0.997305784636461 0.999050922126668 35 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c c.-950A>G Rv2752c_c.-950A>G 2 upstream_gene_variant 3067141 NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1683 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 913 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c c.-951delC Rv2752c_c.-951delC 2 upstream_gene_variant 3067141 1 8 0 8 1 10 5842 21453 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.9995340819084 0.999143327515781 0.999776552276323 0.0909090909090909 0.00229897221381426 0.412779916988382 0 0 0.369416647552819 0 0 0.30849710781876 0 0 2.15204787993135 0.215650024831697 130 2040 False False 0.367220130092434 0.00846382756918765 2.58216900423934 0 0 0.00063124187675269 0.9995340819084 0.999143327515781 0.999776552276323 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c c.-960A>G Rv2752c_c.-960A>G 2 upstream_gene_variant 3067151 1 1 0 1 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 142.964774304408 1 883 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0 0 0.00063124187675269 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c c.966G>A Rv2752c_c.966G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 9 5839 21454 0.000684579839123737 0.000186555462570677 0.00175186028923716 0.99958067371756 0.999204138016772 0.999808239967157 0.307692307692307 0.0909203945720966 0.614261661750705 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.63300412932199 0.367337733398809 5.85390803674755 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 4 8 2716 9631 0.00147058823529411 0.000400826576335422 0.00376097173045195 0.999170038385724 0.99836530325407 0.99964161554927 0.333333333333333 0.0992460911495833 0.651124493581186 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.7730117820324 0.390385568704259 6.62475456740723 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.-966G>T Rv2752c_c.-966G>T 2 upstream_gene_variant 3067157 1 6 0 6 0 6 5843 21457 0 0 0.000631133876986172 0.99972044914504 0.999391635540124 0.999897403075094 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.1200699364824 0.35257212959262 148.5 2040 False False 0 0 3.1200699364824 0 0 0.000631133876986172 0.99972044914504 0.999391635540124 0.999897403075094 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 2720 9635 0 0 0.00135528645033659 0.999585019192862 0.998937828281888 0.999886920491758 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.36894442066688 0.582297391718026 115.5 1102 False False 0 0 0 0 0 0 0 0 0 5.36894442066688 0 0 0.00135528645033659 0.999585019192862 0.998937828281888 0.999886920491758 22 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c c.978C>T Rv2752c_c.978C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 142.940361251077 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 137.910590703348 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Levofloxacin Rv2752c c.-981A>G Rv2752c_c.-981A>G 2 upstream_gene_variant 3067172 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c deletion Rv2752c_deletion 2 feature_ablation (see "Genomic_coordinates" sheet) NA 0 0 0 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1627 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 883 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c LoF Rv2752c_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 173 3 170 134 236 5709 21227 0.0229334246106452 0.0192493251424809 0.0271038285240686 0.989004333038252 0.987517682677546 0.990356212726385 0.362162162162162 0.313114203752578 0.41343552965702 0.0173410404624277 0.00359051636947692 0.0498392679898602 0.0125523012552301 0.00259610464110423 0.0362428741631637 0.0656146641525764 0.0133948784017473 0.195173634951756 3.53737041729502e-14 10 2040 True False 2.11116108671707 1.69129471204169 2.62629798570891 0.000525210084033613 0.00010832404501096 0.00153411204301875 0.989004333038252 0.987517682677546 0.990356212726385 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 103 3 100 66 123 2654 9516 0.0242647058823529 0.018814852828097 0.0307683141502179 0.987239340180516 0.984793530879649 0.989383722044331 0.349206349206349 0.281454309636404 0.421772473020445 0.029126213592233 0.00604727853094184 0.082764942610838 0.0238095238095238 0.00493727032011603 0.0680048643419406 0.10756593820648 0.0218213815303493 0.323974768570454 9.27262122297378e-08 9 1102 True False 0 0 0 0 0 0 0 1.92394361019721 1.39986355380267 2.62403739203701 0.0011290929619872 0.000232906666949847 0.00329610932400168 0.987239340180516 0.984793530879649 0.989383722044331 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ala110fs Rv2752c_p.Ala110fs 2 frameshift (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 5843 21457 0 0 0.000631133876986172 0.99972044914504 0.999391635540124 0.999897403075094 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.1200699364824 0.35257212959262 148.5 2040 False False 0 0 3.1200699364824 0 0 0.000631133876986172 0.99972044914504 0.999391635540124 0.999897403075094 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ala110Ser Rv2752c_p.Ala110Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1673 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 908 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ala155Val Rv2752c_p.Ala155Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0941866911272879 Inf 0.213982274957884 105.5 2040 False False Inf 0.0941866911272879 Inf 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0908652957857324 Inf 0.220082530949106 80 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ala157Thr Rv2752c_p.Ala157Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ala206Thr Rv2752c_p.Ala206Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ala206Val Rv2752c_p.Ala206Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ala20Glu Rv2752c_p.Ala20Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ala20Pro Rv2752c_p.Ala20Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ala20Val Rv2752c_p.Ala20Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ala229fs Rv2752c_p.Ala229fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1628 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 884 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ala239Val Rv2752c_p.Ala239Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89146792489366 1 319.5 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.57852451631077 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 8.57852451631077 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ala252Glu Rv2752c_p.Ala252Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 1 5841 21462 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99995340819084 0.99974043469953 0.999998820398217 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 1746 2040 False False 7.3487416538264 0.382468755528661 432.333734199629 0 0 0.000631349913487419 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 1 2718 9638 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 0.999896254798215 0.999422105789591 0.999997373402351 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 954 1102 False False 0 0 0 0 0 0 0 7.09197939661515 0.368993183584618 417.296682266591 0 0 0.00135628304118183 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ala252Val Rv2752c_p.Ala252Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1655 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 899 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ala254dup Rv2752c_p.Ala254dup 2 inframe_insertion (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5841 21463 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 1 0.999828143201531 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1703 2040 False False Inf 0.689929368506768 Inf 0 0 0.000631349913487419 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 925 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ala254Val Rv2752c_p.Ala254Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 5843 21458 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.0087500478358 0.59157266040946 268 2040 False False 0 0 4.0087500478358 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.57852451631077 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 8.57852451631077 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ala273Thr Rv2752c_p.Ala273Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 1 6 5842 21457 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99972044914504 0.999391635540124 0.999897403075094 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.521823750104981 0 0 0.4592581264399 0 0 4.00924954320777 0.591569100579173 257.5 2040 False False 0.612147666324318 0.0133096260827154 5.04744841661085 0 0 0.00063124187675269 0.99972044914504 0.999391635540124 0.999897403075094 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 1 6 2719 9633 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999377528789293 0.998645638320949 0.999771530871485 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.521823750104981 0 0 0.4592581264399 0 0 3.8685445653815 0.592767182800558 132 1102 False False 0 0 0 0 0 0 0 0.590474439132033 0.0128360606385712 4.87020043259644 0 0 0.0013557845626193 0.999377528789293 0.998645638320949 0.999771530871485 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ala290fs Rv2752c_p.Ala290fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ala290Pro Rv2752c_p.Ala290Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ala292Asp Rv2752c_p.Ala292Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1724 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0 0 0.00063124187675269 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ala296Val Rv2752c_p.Ala296Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 52 0 52 1 64 5842 21399 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.997018124213763 0.996193784338511 0.997702858014229 0.0153846153846153 0.000389428891097221 0.0827630877444663 0 0 0.0684822087033195 0 0 0.0560090893866365 0 0 0.26938661277417 4.82993863473533e-06 21 2040 True False 0.0572337170489558 0.0014309043159148 0.330682590964316 0 0 0.00063124187675269 0.997018124213763 0.996193784338511 0.997702858014229 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 0 11 2720 9628 0 0 0.00135528645033659 0.998858802780371 0.997959002506684 0.999430185159088 0 0 0.284914152918154 0 0 0.30849710781876 0 0 0.284914152918154 0 0 1.58035097305676 0.131070616777933 48.5 1102 False False 0 0 0 0 0 0 0 0 0 1.41143234851738 0 0 0.00135528645033659 0.998858802780371 0.997959002506684 0.999430185159088 112 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ala330fs Rv2752c_p.Ala330fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 6 0 5837 21463 0.0010268697586856 0.000376933373413978 0.00223371319186393 1 0.999828143201531 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 1609 2040 False False Inf 4.32753778579302 Inf 0 0 0.000631782430488341 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ala368fs Rv2752c_p.Ala368fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 5840 21463 0.000513434879342803 0.000105895133877182 0.00149973424244328 1 0.999828143201531 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1668 2040 False False Inf 1.51820267072123 Inf 0 0 0.000631457987209345 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ala376Glu Rv2752c_p.Ala376Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ala376Gly Rv2752c_p.Ala376Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 1 8 5842 21455 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99962726552672 0.99926569731444 0.999839066414514 0.111111111111111 0.00280913674659921 0.482496514917337 0 0 0.4592581264399 0 0 0.369416647552819 0 0 3.12031349628375 0.352578235518943 156 2040 False False 0.45906795617939 0.0103475211102756 3.425357676166 0 0 0.00063124187675269 0.99962726552672 0.99926569731444 0.999839066414514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 6 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ala376Val Rv2752c_p.Ala376Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1764 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 964 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ala378Thr Rv2752c_p.Ala378Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ala378Val Rv2752c_p.Ala378Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 1 4 5842 21459 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99981363276336 0.999522895233871 0.999949218940757 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.56583008746417 0.58432028936451 238 2040 False False 0.918307086614173 0.0186435710006194 9.27999188457764 0 0 0.00063124187675269 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 888 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 7 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ala405fs Rv2752c_p.Ala405fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ala405Thr Rv2752c_p.Ala405Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ala423fs Rv2752c_p.Ala423fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ala433Ser Rv2752c_p.Ala433Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1646 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 896 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ala436Asp Rv2752c_p.Ala436Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ala441Ser Rv2752c_p.Ala441Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ala454fs Rv2752c_p.Ala454fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1708 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 929 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ala474Thr Rv2752c_p.Ala474Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ala489Val Rv2752c_p.Ala489Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ala503Gly Rv2752c_p.Ala503Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ala520Ser Rv2752c_p.Ala520Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ala521Pro Rv2752c_p.Ala521Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ala521Thr Rv2752c_p.Ala521Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1647 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ala530fs Rv2752c_p.Ala530fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1734 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 947 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ala530Thr Rv2752c_p.Ala530Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89146792489366 1 319.5 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ala89Glu Rv2752c_p.Ala89Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 142.964774304408 1 883 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0 0 0.00063124187675269 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ala89Val Rv2752c_p.Ala89Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1661 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Arg120fs Rv2752c_p.Arg120fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5841 21463 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 1 0.999828143201531 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1718 2040 False False Inf 0.689929368506768 Inf 0 0 0.000631349913487419 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 938 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Arg120His Rv2752c_p.Arg120His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1648 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 897 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Arg17Gly Rv2752c_p.Arg17Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Arg17Pro Rv2752c_p.Arg17Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Arg17Trp Rv2752c_p.Arg17Trp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1738 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Arg227Gly Rv2752c_p.Arg227Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89146792489366 1 319.5 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Arg227Trp Rv2752c_p.Arg227Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Arg244Trp Rv2752c_p.Arg244Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Arg257Trp Rv2752c_p.Arg257Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 142.964774304408 1 883 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0 0 0.00063124187675269 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Arg258Gln Rv2752c_p.Arg258Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1769 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 967 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Arg258Leu Rv2752c_p.Arg258Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 11 0 11 1 13 5842 21450 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99939430648092 0.998964468353895 0.999677455549724 0.0714285714285714 0.00180678065912538 0.338684489931821 0 0 0.284914152918154 0 0 0.24705263800047 0 0 1.46348037152978 0.135834573253397 81 2040 False False 0.282437521396781 0.00664836898198944 1.88119052490052 0 0 0.00063124187675269 0.99939430648092 0.998964468353895 0.999677455549724 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 11 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Arg258* Rv2752c_p.Arg258* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Arg264Leu Rv2752c_p.Arg264Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1601 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Arg268Cys Rv2752c_p.Arg268Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Arg280* Rv2752c_p.Arg280* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Arg317Pro Rv2752c_p.Arg317Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Arg320_Gly321insMetSerArg Rv2752c_p.Arg320_Gly321insMetSerArg 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1602 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0 0 0.00063124187675269 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Arg320His Rv2752c_p.Arg320His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Arg320Leu Rv2752c_p.Arg320Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 142.964774304408 1 883 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0 0 0.00063124187675269 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 137.961202437293 1 457.5 1102 False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 0 0 0.0013557845626193 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Arg361Gly Rv2752c_p.Arg361Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 17 1 16 2 18 5841 21445 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99916134743512 0.998674889990656 0.999502887997069 0.1 0.0123485271702948 0.316982714019082 0.0588235294117647 0.00148817439126663 0.28688939666722 0.0526315789473684 0.00133162880417942 0.260280654195214 0.229466272898476 0.00547459776336976 1.47774531368705 0.146189794086525 85 2040 False False 0.407940040708402 0.0458947155795477 1.70471612369336 0.000171174255391989 4.33374753915718e-06 0.000953348826018904 0.99916134743512 0.998674889990656 0.999502887997069 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 17 1 16 2 18 2718 9621 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 0.99813258636788 0.997050280966737 0.998892888551341 0.1 0.0123485271702948 0.316982714019082 0.0588235294117647 0.00148817439126663 0.28688939666722 0.0526315789473684 0.00133162880417942 0.260280654195214 0.221233443708609 0.00527731707054512 1.42541606097964 0.144376302361751 56 1102 False False 0 0 0 0 0 0 0 0.393303899926416 0.0442348973895599 1.64457037423697 0.000367782272894446 9.31139761383543e-06 0.00204742980952803 0.99813258636788 0.997050280966737 0.998892888551341 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Arg361Ser Rv2752c_p.Arg361Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Arg389Trp Rv2752c_p.Arg389Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1589 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Arg391fs Rv2752c_p.Arg391fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 3 1 5840 21462 0.000513434879342803 0.000105895133877182 0.00149973424244328 0.99995340819084 0.99974043469953 0.999998820398217 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 1755 2040 False False 11.025 0.884946155157416 576.804300084131 0 0 0.000631457987209345 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Arg391Ser Rv2752c_p.Arg391Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Arg39fs Rv2752c_p.Arg39fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 3.67374186922286 0.0467931454016956 287.712465214691 0.382182295738733 180 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 3.54468554615667 0.045140524816893 277.645286351599 0.391742630950597 101.5 1102 False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Arg39* Rv2752c_p.Arg39* 2 stop_gained (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 5843 21458 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.0087500478358 0.59157266040946 268 2040 False False 0 0 4.0087500478358 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.57852451631077 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 8.57852451631077 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Arg404Ser Rv2752c_p.Arg404Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Arg465Gln Rv2752c_p.Arg465Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Arg465Trp Rv2752c_p.Arg465Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 2 9 5841 21454 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99958067371756 0.999204138016772 0.999808239967157 0.181818181818181 0.0228311982999596 0.517755852360172 0 0 0.4592581264399 0 0 0.336267116879942 0 0 3.12070271732603 0.352588004329468 160 2040 False False 0.816222488538872 0.0857956692845824 3.94510286595224 0 0 0.000631349913487419 0.99958067371756 0.999204138016772 0.999808239967157 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 2720 9635 0 0 0.00135528645033659 0.999585019192862 0.998937828281888 0.999886920491758 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 8.57763452631882 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 5.36894442066688 0 0 0.00135528645033659 0.999585019192862 0.998937828281888 0.999886920491758 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Arg495dup Rv2752c_p.Arg495dup 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1704 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Arg528Gln Rv2752c_p.Arg528Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1698 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Arg534fs Rv2752c_p.Arg534fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1705 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 926 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Arg535Cys Rv2752c_p.Arg535Cys 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 9 5840 21454 0.000513434879342803 0.000105895133877182 0.00149973424244328 0.99958067371756 0.999204138016772 0.999808239967157 0.25 0.0548606445279927 0.571858461878189 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1594 2040 False False 1.22454337899543 0.213166253079868 4.90876155405007 0 0 0.000631457987209345 0.99958067371756 0.999204138016772 0.999808239967157 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 9 2718 9630 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 0.99906629318394 0.998228276906464 0.999572963722204 0.181818181818181 0.0228311982999596 0.517755852360172 NA NA NA 0 0 0.336267116879942 NA NA NA NA 867 1102 False False 0 0 0 0 0 0 0 0.787343635025754 0.0827356806508646 3.80697946362256 0 0 0.00135628304118183 0.99906629318394 0.998228276906464 0.999572963722204 8 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Arg547Cys Rv2752c_p.Arg547Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1712 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Arg547fs Rv2752c_p.Arg547fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Arg547His Rv2752c_p.Arg547His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1652 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 898 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Arg65Ser Rv2752c_p.Arg65Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Arg97fs Rv2752c_p.Arg97fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 3 3 5840 21460 0.000513434879342803 0.000105895133877182 0.00149973424244328 0.99986022457252 0.999591571764338 0.999971174018896 0.5 0.118117248757025 0.881882751242974 0 0 0.841886116991581 0 0 0.707598226178713 0 0 19.5766929980907 1 319.5 2040 False False 3.67465753424657 0.492014255735427 27.463249173756 0 0 0.000631457987209345 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 917 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Arg97* Rv2752c_p.Arg97* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 3 3 5840 21460 0.000513434879342803 0.000105895133877182 0.00149973424244328 0.99986022457252 0.999591571764338 0.999971174018896 0.5 0.118117248757025 0.881882751242974 0 0 0.975 0 0 0.707598226178713 0 0 143.000328686365 1 883 2040 False False 3.67465753424657 0.492014255735427 27.463249173756 0 0 0.000631457987209345 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Asn30Asp Rv2752c_p.Asn30Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Asn30His Rv2752c_p.Asn30His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1699 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Asn30Lys Rv2752c_p.Asn30Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 9 0 9 1 12 5842 21451 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99944089829008 0.999023565718772 0.999711071680148 0.0769230769230769 0.00194562849734675 0.360297435267877 0 0 0.336267116879942 0 0 0.264648469397051 0 0 1.86090760037182 0.219685477364651 136 2040 False False 0.305988246034463 0.00716032492979931 2.06893448789797 0 0 0.00063124187675269 0.99944089829008 0.999023565718772 0.999711071680148 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 1 11 2719 9628 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.998858802780371 0.997959002506684 0.999430185159088 0.0833333333333333 0.00210759323186022 0.384796165150944 0 0 0.369416647552819 0 0 0.284914152918154 0 0 2.0759411114857 0.213322023544199 65 1102 False False 0 0 0 0 0 0 0 0.321909793038884 0.00747960585022801 2.21688560239189 0 0 0.0013557845626193 0.998858802780371 0.997959002506684 0.999430185159088 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Asn30Ser Rv2752c_p.Asn30Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 15 5843 21448 0 0 0.000631133876986172 0.9993011228626 0.9988475700008 0.999608792686571 0 0 0.218019360910534 0 0 0.409616397225003 0 0 0.218019360910534 0 0 2.54758984266255 0.358214841463256 172 2040 False False 0 0 1.02381522685458 0 0 0.000631133876986172 0.9993011228626 0.9988475700008 0.999608792686571 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 12 2720 9627 0 0 0.00135528645033659 0.998755057578587 0.997826347023296 0.999356559855396 0 0 0.264648469397051 0 0 0.521823750104981 0 0 0.264648469397051 0 0 3.8647135418557 0.592807785950617 140 1102 False False 0 0 0 0 0 0 0 0 0 1.2747953585009 0 0 0.00135528645033659 0.998755057578587 0.997826347023296 0.999356559855396 7 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Asn344fs Rv2752c_p.Asn344fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1693 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Asn386Asp Rv2752c_p.Asn386Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Asn392fs Rv2752c_p.Asn392fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1585 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Asn406Lys Rv2752c_p.Asn406Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Asn406Ser Rv2752c_p.Asn406Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 19.5666713375759 1 883 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Asn522fs Rv2752c_p.Asn522fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Asp152Ala Rv2752c_p.Asp152Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.56487735727821 0.58431003819195 215.5 2040 False False 0 0 5.56487735727821 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Asp152fs Rv2752c_p.Asp152fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Asp170_Gly195del Rv2752c_p.Asp170_Gly195del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0941866911272879 Inf 0.213982274957884 105.5 2040 False False Inf 0.0941866911272879 Inf 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Asp170Asn Rv2752c_p.Asp170Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 5843 21458 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 5.56461804904681 0.584307247454343 202 2040 False False 0 0 4.0087500478358 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 15 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Asp170Gly Rv2752c_p.Asp170Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 2 5841 21461 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99990681638168 0.999663429698698 0.999988714832292 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 142.982548456817 1 883 2040 False False 3.67419962335216 0.266252080252227 50.6812073544246 0 0 0.000631349913487419 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 958 1102 False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 0 0 0.0013557845626193 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Asp174fs Rv2752c_p.Asp174fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 142.964774304408 1 883 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0 0 0.00063124187675269 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Asp174Glu Rv2752c_p.Asp174Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Asp179fs Rv2752c_p.Asp179fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Asp184fs Rv2752c_p.Asp184fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Asp184Glu Rv2752c_p.Asp184Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Asp184Gly Rv2752c_p.Asp184Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Asp202Ala Rv2752c_p.Asp202Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1694 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0 0 0.00063124187675269 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 921 1102 False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 0 0 0.0013557845626193 0.999896254798215 0.999422105789591 0.999997373402351 5 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Asp202Tyr Rv2752c_p.Asp202Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Asp230Tyr Rv2752c_p.Asp230Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1674 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Asp243fs Rv2752c_p.Asp243fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Asp250Glu Rv2752c_p.Asp250Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Asp332fs Rv2752c_p.Asp332fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1662 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 903 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Asp332Gly Rv2752c_p.Asp332Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 5 3 5838 21460 0.000855724798904672 0.00027790803803495 0.00199583691247191 0.99986022457252 0.999591571764338 0.999971174018896 0.625 0.244863216366551 0.914766585862746 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89908261456576 1 319.5 2040 False False 6.12652734954893 1.19146359990854 39.4644754416156 0 0 0.000631674245690789 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 2 3 2718 9636 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 0.999688764394646 0.999090709558603 0.999935811136198 0.4 0.0527449505263169 0.853367200365326 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.58483775120996 1 147 1102 False False 0 0 0 0 0 0 0 2.3635025754231 0.197291785205426 20.6413600392426 0 0 0.00135628304118183 0.999688764394646 0.999090709558603 0.999935811136198 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Asp332Tyr Rv2752c_p.Asp332Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1590 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Asp430Ala Rv2752c_p.Asp430Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Asp44Ala Rv2752c_p.Asp44Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 1 5841 21462 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99995340819084 0.99974043469953 0.999998820398217 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 1663 2040 False False 7.3487416538264 0.382468755528661 432.333734199629 0 0 0.000631349913487419 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Asp44Gly Rv2752c_p.Asp44Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 142.964774304408 1 883 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0 0 0.00063124187675269 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Asp450Gly Rv2752c_p.Asp450Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 8 5 5835 21458 0.00136915967824747 0.00059128544285425 0.00269599843431209 0.9997670409542 0.99945643574724 0.999924354643808 0.615384615384615 0.315777602914063 0.861420661109839 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.01424729234419 0.591533815633294 248.5 2040 False False 5.88394173093401 1.69631346127004 22.8659263023028 0 0 0.00063199891129229 0.9997670409542 0.99945643574724 0.999924354643808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 2719 9637 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999792509596431 0.999250676427901 0.999974870961701 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8778635755656 1 457.5 1102 False False 0 0 0 0 0 0 0 1.77215888194189 0.0300270423699391 34.0580978516331 0 0 0.0013557845626193 0.999792509596431 0.999250676427901 0.999974870961701 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Asp500fs Rv2752c_p.Asp500fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5841 21463 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 1 0.999828143201531 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1629 2040 False False Inf 0.689929368506768 Inf 0 0 0.000631349913487419 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 2718 9639 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 1 0.999617369678334 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 885 1102 False False 0 0 0 0 0 0 0 Inf 0.665658435310444 Inf 0 0 0.00135628304118183 1 0.999617369678334 1 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Asp63Ala Rv2752c_p.Asp63Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5841 21463 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 1 0.999828143201531 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1756 2040 False False Inf 0.689929368506768 Inf 0 0 0.000631349913487419 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Asp63Gly Rv2752c_p.Asp63Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 8.89105370607792 1 883 2040 False False 0 0 5.56487735727821 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Asp72fs Rv2752c_p.Asp72fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 1 3 5842 21460 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99986022457252 0.999591571764338 0.999971174018896 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1610 2040 False False 1.22446650690402 0.0233203404016305 15.2512395040111 0 0 0.00063124187675269 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 3 2719 9636 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999688764394646 0.999090709558603 0.999935811136198 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 874 1102 False False 0 0 0 0 0 0 0 1.18131666053696 0.0224941657498392 14.7172429763561 0 0 0.0013557845626193 0.999688764394646 0.999090709558603 0.999935811136198 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Asp72Glu Rv2752c_p.Asp72Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5841 21463 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 1 0.999828143201531 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1725 2040 False False Inf 0.689929368506768 Inf 0 0 0.000631349913487419 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Asp73Glu Rv2752c_p.Asp73Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1739 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 949 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Asp85Ala Rv2752c_p.Asp85Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Asp85fs Rv2752c_p.Asp85fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 5840 21463 0.000513434879342803 0.000105895133877182 0.00149973424244328 1 0.999828143201531 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1591 2040 False False Inf 1.51820267072123 Inf 0 0 0.000631457987209345 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Asp85Gly Rv2752c_p.Asp85Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 4 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Cys116Phe Rv2752c_p.Cys116Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1713 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Cys201Arg Rv2752c_p.Cys201Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Cys201fs Rv2752c_p.Cys201fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Cys201* Rv2752c_p.Cys201* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1726 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 942 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Cys237Arg Rv2752c_p.Cys237Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1684 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Cys45* Rv2752c_p.Cys45* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1685 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 914 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Cys45Tyr Rv2752c_p.Cys45Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1706 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 927 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gln132fs Rv2752c_p.Gln132fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1644 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gln132Pro Rv2752c_p.Gln132Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 4 5842 21459 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99981363276336 0.999522895233871 0.999949218940757 0.2 0.00505076337946806 0.716417936118089 0 0 0.707598226178713 0 0 0.602364635616474 0 0 8.89257553126729 1 883 2040 False False 0.918307086614173 0.0186435710006194 9.27999188457764 0 0 0.00063124187675269 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gln175His Rv2752c_p.Gln175His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1747 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0 0 0.00063124187675269 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 955 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gln246Pro Rv2752c_p.Gln246Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gln246* Rv2752c_p.Gln246* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 9 1 5834 21462 0.00154030463802841 0.000704559638966774 0.00292195530235611 0.99995340819084 0.99974043469953 0.999998820398217 0.9 0.554983882971804 0.997471421455538 0 0 0.975 0 0 0.975 0 0 143.160379349492 1 883 2040 False False 33.1090161124442 4.58571372485259 1440.26357420393 0 0 0.000632107207336799 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 6 1 2714 9638 0.00220588235294117 0.000809936709089192 0.00479504888600855 0.999896254798215 0.999422105789591 0.999997373402351 0.857142857142857 0.421276802956804 0.996389703138099 0 0 0.975 0 0 0.975 0 0 138.214819350558 1 457.5 1102 False False 0 0 0 0 0 0 0 21.3072955047899 2.58272233950832 975.045278123278 0 0 0.00135828062632211 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gln247* Rv2752c_p.Gln247* 2 stop_gained (see "Genomic_coordinates" sheet) 1 23 0 23 34 43 5809 21420 0.00581892863255177 0.00403304404399734 0.00812196208487503 0.997996552206122 0.997302307222645 0.998549727129128 0.441558441558441 0.328419808930008 0.559329779387531 0 0 0.148185128915224 0 0 0.0822111211541385 0 0 0.641744270554704 0.00823982396072077 37 2040 False False 2.91560409468867 1.80133104942647 4.6849144354231 0 0 0.000634826722424094 0.997996552206122 0.997302307222645 0.998549727129128 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 16 0 16 8 23 2712 9616 0.00294117647058823 0.00127061997302132 0.00578702225151795 0.997613860358958 0.996421757225608 0.998486809448329 0.258064516129032 0.118563995829551 0.446133934334896 0 0 0.205907214207822 0 0 0.148185128915224 0 0 0.920154656627235 0.0313431942521524 33 1102 False False 0 0 0 0 0 0 0 1.23329485699628 0.476377116363 2.86014001222016 0 0 0.00135928162710748 0.997613860358958 0.996421757225608 0.998486809448329 21 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gln275Arg Rv2752c_p.Gln275Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gln308His Rv2752c_p.Gln308His 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 19.5666713375759 1 883 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gln308Pro Rv2752c_p.Gln308Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 5842 21461 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99990681638168 0.999663429698698 0.999988714832292 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 142.958128195713 1 883 2040 False False 1.83678534748373 0.0311281139040964 35.2896458967866 0 0 0.00063124187675269 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 875 1102 False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 0 0 0.0013557845626193 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gln308* Rv2752c_p.Gln308* 2 stop_gained (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89146792489366 1 319.5 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gln367Pro Rv2752c_p.Gln367Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 5843 21458 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.0087500478358 0.59157266040946 268 2040 False False 0 0 4.0087500478358 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 2720 9635 0 0 0.00135528645033659 0.999585019192862 0.998937828281888 0.999886920491758 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.36894442066688 0.582297391718026 115.5 1102 False False 0 0 0 0 0 0 0 0 0 5.36894442066688 0 0 0.00135528645033659 0.999585019192862 0.998937828281888 0.999886920491758 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gln367* Rv2752c_p.Gln367* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gln417* Rv2752c_p.Gln417* 2 stop_gained (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 19.5666713375759 1 883 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 137.896313968788 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gln485Arg Rv2752c_p.Gln485Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gln531Glu Rv2752c_p.Gln531Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1586 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 865 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gln531Pro Rv2752c_p.Gln531Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5841 21463 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 1 0.999828143201531 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1707 2040 False False Inf 0.689929368506768 Inf 0 0 0.000631349913487419 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 2718 9639 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 1 0.999617369678334 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 928 1102 False False 0 0 0 0 0 0 0 Inf 0.665658435310444 Inf 0 0 0.00135628304118183 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gln531* Rv2752c_p.Gln531* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1630 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gln548fs Rv2752c_p.Gln548fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1675 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Glu130Lys Rv2752c_p.Glu130Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1595 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Glu140fs Rv2752c_p.Glu140fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1656 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0 0 0.00063124187675269 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 900 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Glu142Gly Rv2752c_p.Glu142Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1603 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Glu142* Rv2752c_p.Glu142* 2 stop_gained (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Glu207* Rv2752c_p.Glu207* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1604 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Glu217* Rv2752c_p.Glu217* 2 stop_gained (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Glu310Ala Rv2752c_p.Glu310Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89146792489366 1 319.5 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Glu322* Rv2752c_p.Glu322* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1611 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Glu345Lys Rv2752c_p.Glu345Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1605 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 870 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Glu345* Rv2752c_p.Glu345* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0941866911272879 Inf 0.213982274957884 105.5 2040 False False Inf 0.0941866911272879 Inf 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0908652957857324 Inf 0.220082530949106 80 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Glu35Asp Rv2752c_p.Glu35Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Glu35fs Rv2752c_p.Glu35fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1727 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Glu380Lys Rv2752c_p.Glu380Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1748 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 956 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Glu380* Rv2752c_p.Glu380* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Glu424Gly Rv2752c_p.Glu424Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Glu464Gly Rv2752c_p.Glu464Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5841 21463 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 1 0.999828143201531 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1618 2040 False False Inf 0.689929368506768 Inf 0 0 0.000631349913487419 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Glu464Lys Rv2752c_p.Glu464Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Glu499fs Rv2752c_p.Glu499fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 6 0 5837 21463 0.0010268697586856 0.000376933373413978 0.00223371319186393 1 0.999828143201531 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 1757 2040 False False Inf 4.32753778579302 Inf 0 0 0.000631782430488341 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 6 0 2714 9639 0.00220588235294117 0.000809936709089192 0.00479504888600855 1 0.999617369678334 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 959 1102 False False 0 0 0 0 0 0 0 Inf 4.17793015473029 Inf 0 0 0.00135828062632211 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Glu499Gly Rv2752c_p.Glu499Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Glu505Gln Rv2752c_p.Glu505Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1619 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 879 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Glu516* Rv2752c_p.Glu516* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1676 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Glu543fs Rv2752c_p.Glu543fs 2 frameshift (see "Genomic_coordinates" sheet) 1 7 0 7 5 9 5838 21454 0.000855724798904672 0.00027790803803495 0.00199583691247191 0.99958067371756 0.999204138016772 0.999808239967157 0.357142857142857 0.127598429859159 0.648619889384008 0 0 0.409616397225003 0 0 0.336267116879942 0 0 2.55048531193581 0.358179716472392 166 2040 False False 2.04160481138898 0.537264592106154 6.78652492698381 0 0 0.000631674245690789 0.99958067371756 0.999204138016772 0.999808239967157 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 3 3 2717 9636 0.00110294117647058 0.000227510766880298 0.0032198465640147 0.999688764394646 0.999090709558603 0.999935811136198 0.5 0.118117248757025 0.881882751242974 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.58799785181391 1 457.5 1102 False False 0 0 0 0 0 0 0 3.54655870445344 0.474683509027965 26.4906268935459 0 0 0.00135678188642832 0.999688764394646 0.999090709558603 0.999935811136198 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Glu543* Rv2752c_p.Glu543* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1714 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 934 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Glu54Ala Rv2752c_p.Glu54Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 2 5841 21461 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99990681638168 0.999663429698698 0.999988714832292 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 142.982548456817 1 883 2040 False False 3.67419962335216 0.266252080252227 50.6812073544246 0 0 0.000631349913487419 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Glu54Gly Rv2752c_p.Glu54Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Glu68Asp Rv2752c_p.Glu68Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1606 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 871 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 16 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Glu68* Rv2752c_p.Glu68* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Glu75* Rv2752c_p.Glu75* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gly104Ala Rv2752c_p.Gly104Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 5842 21461 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99990681638168 0.999663429698698 0.999988714832292 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5709198500876 1 883 2040 False False 1.83678534748373 0.0311281139040964 35.2896458967866 0 0 0.00063124187675269 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 901 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gly15Arg Rv2752c_p.Gly15Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gly161Arg Rv2752c_p.Gly161Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1664 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gly161Cys Rv2752c_p.Gly161Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gly161Ser Rv2752c_p.Gly161Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 97 3 94 22 111 5821 21352 0.00376518911518055 0.0023610823891641 0.00569502395783134 0.994828309183245 0.993775242727735 0.995743691790054 0.165413533834586 0.106663239269302 0.239658790222783 0.0309278350515463 0.00642404745315555 0.0877317821404356 0.0263157894736842 0.00546017831828114 0.0749818451000722 0.117066965901157 0.0237062110780587 0.35298059765654 3.51711260433125e-07 17 2040 True False 0.727010466917699 0.437571581044058 1.15743021151075 0.00051510989010989 0.000106240643186301 0.00150462449674124 0.994828309183245 0.993775242727735 0.995743691790054 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 36 2 34 16 37 2704 9602 0.00588235294117647 0.00336589967267386 0.00953503998064353 0.996161427533976 0.994712877434656 0.997295894108395 0.30188679245283 0.183402016182152 0.443434015839577 0.0555555555555555 0.00680030065402281 0.186636706457554 0.0512820512820512 0.00627197209569041 0.173244781373605 0.208884441350504 0.024293315148793 0.815799097323673 0.0142340734911727 26 1102 False False 0 0 0 0 0 0 0 1.5355829201983 0.796213688686424 2.83424300063087 0.000739098300073909 8.95207693482568e-05 0.00266730095854054 0.996161427533976 0.994712877434656 0.997295894108395 91 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gly169Arg Rv2752c_p.Gly169Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gly169Val Rv2752c_p.Gly169Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 5842 21461 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99990681638168 0.999663429698698 0.999988714832292 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 142.958128195713 1 883 2040 False False 1.83678534748373 0.0311281139040964 35.2896458967866 0 0 0.00063124187675269 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gly180Cys Rv2752c_p.Gly180Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1612 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 876 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gly187Asp Rv2752c_p.Gly187Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 142.93371627475 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gly210Cys Rv2752c_p.Gly210Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1758 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gly22Cys Rv2752c_p.Gly22Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gly22Ser Rv2752c_p.Gly22Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1631 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gly256fs Rv2752c_p.Gly256fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gly256Ser Rv2752c_p.Gly256Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1740 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gly263fs Rv2752c_p.Gly263fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gly28Cys Rv2752c_p.Gly28Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1613 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gly28Ser Rv2752c_p.Gly28Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 5 6 5838 21457 0.000855724798904672 0.00027790803803495 0.00199583691247191 0.99972044914504 0.999391635540124 0.999897403075094 0.454545454545454 0.167488094063707 0.766206402340654 0.333333333333333 0.00840375865961264 0.905700675949754 0.142857142857142 0.00361029686190058 0.578723197043195 1.83770126755738 0.0311436324979904 35.293029098631 0.514238642832829 190 2040 False False 3.06283544592897 0.739141831347787 12.0457452127097 0.000171262202431923 4.3359741557749e-06 0.000953838452137429 0.99972044914504 0.999391635540124 0.999897403075094 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 5 6 2715 9633 0.00183823529411764 0.000597130943349739 0.00428457163587036 0.999377528789293 0.998645638320949 0.999771530871485 0.454545454545454 0.167488094063707 0.766206402340654 0.333333333333333 0.00840375865961264 0.905700675949754 0.142857142857142 0.00361029686190058 0.578723197043195 1.77403314917127 0.0300587835095457 34.093747131261 0.52530019718599 107 1102 False False 0 0 0 0 0 0 0 2.95672191528545 0.713186099662177 11.6338720162162 0.000368188512518409 9.32168261480901e-06 0.00204968942684598 0.999377528789293 0.998645638320949 0.999771530871485 4 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gly306Asp Rv2752c_p.Gly306Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1669 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 905 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gly321Thr Rv2752c_p.Gly321Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gly331Ser Rv2752c_p.Gly331Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1587 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gly343Cys Rv2752c_p.Gly343Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1749 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gly350Glu Rv2752c_p.Gly350Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1770 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gly374Arg Rv2752c_p.Gly374Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1730 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gly387Arg Rv2752c_p.Gly387Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gly387Glu Rv2752c_p.Gly387Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1632 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gly38fs Rv2752c_p.Gly38fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1607 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 872 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gly38Ser Rv2752c_p.Gly38Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gly398Arg Rv2752c_p.Gly398Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gly414Asp Rv2752c_p.Gly414Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1719 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 939 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gly414Ser Rv2752c_p.Gly414Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gly440Ser Rv2752c_p.Gly440Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gly445fs Rv2752c_p.Gly445fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1715 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 935 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gly451Asp Rv2752c_p.Gly451Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 142.93371627475 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gly451Ser Rv2752c_p.Gly451Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 5843 21458 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 5.56461804904681 0.584307247454343 202 2040 False False 0 0 4.0087500478358 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 5 2720 9634 0 0 0.00135528645033659 0.999481273991078 0.998789885214303 0.999831550309162 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 5.36838728679065 0.582292204187908 111 1102 False False 0 0 0 0 0 0 0 0 0 3.8675231049739 0 0 0.00135528645033659 0.999481273991078 0.998789885214303 0.999831550309162 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gly46Cys Rv2752c_p.Gly46Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1614 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 877 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gly484Ser Rv2752c_p.Gly484Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1620 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gly496Ala Rv2752c_p.Gly496Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 19.5666713375759 1 883 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 6 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gly496fs Rv2752c_p.Gly496fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1731 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 944 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gly51Ser Rv2752c_p.Gly51Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gly542Glu Rv2752c_p.Gly542Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gly56fs Rv2752c_p.Gly56fs 2 frameshift (see "Genomic_coordinates" sheet) 1 7 0 7 1 7 5842 21456 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99967385733588 0.999328137654343 0.999868864001311 0.125 0.0031597235312519 0.526509670875206 0 0 0.409616397225003 0 0 0.409616397225003 0 0 2.54897626717034 0.358197937048468 167 2040 False False 0.524673546241502 0.0116431407170618 4.08534979936462 0 0 0.00063124187675269 0.99967385733588 0.999328137654343 0.999868864001311 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 1 4 2719 9635 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999585019192862 0.998937828281888 0.999886920491758 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.37091971678909 0.582315775027881 122 1102 False False 0 0 0 0 0 0 0 0.885895549834498 0.0179820541723419 8.95537117058933 0 0 0.0013557845626193 0.999585019192862 0.998937828281888 0.999886920491758 5 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gly56Val Rv2752c_p.Gly56Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gly82Glu Rv2752c_p.Gly82Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 142.93371627475 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 137.896313968788 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gly88Arg Rv2752c_p.Gly88Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Gly88Glu Rv2752c_p.Gly88Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 4 1 5839 21462 0.000684579839123737 0.000186555462570677 0.00175186028923716 0.99995340819084 0.99974043469953 0.999998820398217 0.8 0.28358206388191 0.994949236620532 NA NA NA 0 0 0.975 NA NA NA NA 1615 2040 False False 14.7025175543757 1.45439517656642 721.12316039564 0 0 0.000631566097937464 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 878 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.His136Asp Rv2752c_p.His136Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.His148Arg Rv2752c_p.His148Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 142.964774304408 1 883 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0 0 0.00063124187675269 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.His148dup Rv2752c_p.His148dup 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.His148Pro Rv2752c_p.His148Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89146792489366 1 319.5 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.His148Tyr Rv2752c_p.His148Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.His167Arg Rv2752c_p.His167Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 8.89105370607792 1 883 2040 False False 0 0 5.56487735727821 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 2720 9635 0 0 0.00135528645033659 0.999585019192862 0.998937828281888 0.999886920491758 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 8.57763452631882 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 5.36894442066688 0 0 0.00135528645033659 0.999585019192862 0.998937828281888 0.999886920491758 6 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.His167Pro Rv2752c_p.His167Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.His223Tyr Rv2752c_p.His223Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.His323Arg Rv2752c_p.His323Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.His371Arg Rv2752c_p.His371Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.His371Asp Rv2752c_p.His371Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1649 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.His371Tyr Rv2752c_p.His371Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 1 3 3 3 5840 21460 0.000513434879342803 0.000105895133877182 0.00149973424244328 0.99986022457252 0.999591571764338 0.999971174018896 0.5 0.118117248757025 0.881882751242974 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 1.22488584474885 0.0233283255103695 15.2564636730184 1 883 2040 False False 3.67465753424657 0.492014255735427 27.463249173756 0.000171203561034069 4.33448949056051e-06 0.000953511978863128 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 1 2 2719 9637 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999792509596431 0.999250676427901 0.999974870961701 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 1.77215888194189 0.0300270423699391 34.0580978516331 0.525631118756244 109 1102 False False 0 0 0 0 0 0 0 1.77215888194189 0.0300270423699391 34.0580978516331 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999792509596431 0.999250676427901 0.999974870961701 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.His375Arg Rv2752c_p.His375Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1732 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.His375fs Rv2752c_p.His375fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1741 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0 0 0.00063124187675269 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 950 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.His375Tyr Rv2752c_p.His375Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 142.93371627475 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.His397Arg Rv2752c_p.His397Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 142.964774304408 1 883 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0 0 0.00063124187675269 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 14 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.His397Tyr Rv2752c_p.His397Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 19.5666713375759 1 883 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 137.896313968788 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.His491_Gln531del Rv2752c_p.His491_Gln531del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.His491fs Rv2752c_p.His491fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 5842 21461 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99990681638168 0.999663429698698 0.999988714832292 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5709198500876 1 883 2040 False False 1.83678534748373 0.0311281139040964 35.2896458967866 0 0 0.00063124187675269 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 137.961202437293 1 457.5 1102 False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 0 0 0.0013557845626193 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.His491Tyr Rv2752c_p.His491Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 8 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.His493Arg Rv2752c_p.His493Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1665 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0 0 0.00063124187675269 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.His493Pro Rv2752c_p.His493Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 2 3 5841 21460 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99986022457252 0.999591571764338 0.999971174018896 0.4 0.0527449505263169 0.853367200365326 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89451223755799 1 883 2040 False False 2.44935227986075 0.204519727205419 21.3860749684357 0 0 0.000631349913487419 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 2719 9637 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999792509596431 0.999250676427901 0.999974870961701 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8778635755656 1 457.5 1102 False False 0 0 0 0 0 0 0 1.77215888194189 0.0300270423699391 34.0580978516331 0 0 0.0013557845626193 0.999792509596431 0.999250676427901 0.999974870961701 4 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.His52Asp Rv2752c_p.His52Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.His66fs Rv2752c_p.His66fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5841 21463 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 1 0.999828143201531 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1733 2040 False False Inf 0.689929368506768 Inf 0 0 0.000631349913487419 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 2718 9639 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 1 0.999617369678334 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 945 1102 False False 0 0 0 0 0 0 0 Inf 0.665658435310444 Inf 0 0 0.00135628304118183 1 0.999617369678334 1 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.His81Arg Rv2752c_p.His81Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 2 5842 21461 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99990681638168 0.999663429698698 0.999988714832292 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1666 2040 False False 1.83678534748373 0.0311281139040964 35.2896458967866 0 0 0.00063124187675269 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 2 2719 9637 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999792509596431 0.999250676427901 0.999974870961701 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 904 1102 False False 0 0 0 0 0 0 0 1.77215888194189 0.0300270423699391 34.0580978516331 0 0 0.0013557845626193 0.999792509596431 0.999250676427901 0.999974870961701 4 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.His81Pro Rv2752c_p.His81Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1720 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 940 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.His81Tyr Rv2752c_p.His81Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 5843 21458 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.0087500478358 0.59157266040946 268 2040 False False 0 0 4.0087500478358 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 2720 9635 0 0 0.00135528645033659 0.999585019192862 0.998937828281888 0.999886920491758 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.36894442066688 0.582297391718026 115.5 1102 False False 0 0 0 0 0 0 0 0 0 5.36894442066688 0 0 0.00135528645033659 0.999585019192862 0.998937828281888 0.999886920491758 4 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.His83Arg Rv2752c_p.His83Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 1 6 5842 21457 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99972044914504 0.999391635540124 0.999897403075094 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.602364635616474 0 0 0.4592581264399 0 0 5.56531138221033 0.584314704024368 230 2040 False False 0.612147666324318 0.0133096260827154 5.04744841661085 0 0 0.00063124187675269 0.99972044914504 0.999391635540124 0.999897403075094 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 137.961202437293 1 457.5 1102 False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 0 0 0.0013557845626193 0.999896254798215 0.999422105789591 0.999997373402351 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.His83Asn Rv2752c_p.His83Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.His83Pro Rv2752c_p.His83Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 1 6 5842 21457 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99972044914504 0.999391635540124 0.999897403075094 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.602364635616474 0 0 0.4592581264399 0 0 5.56531138221033 0.584314704024368 230 2040 False False 0.612147666324318 0.0133096260827154 5.04744841661085 0 0 0.00063124187675269 0.99972044914504 0.999391635540124 0.999897403075094 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 4 2719 9635 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999585019192862 0.998937828281888 0.999886920491758 0.2 0.00505076337946806 0.716417936118089 0 0 0.707598226178713 0 0 0.602364635616474 0 0 8.5807896567567 1 147 1102 False False 0 0 0 0 0 0 0 0.885895549834498 0.0179820541723419 8.95537117058933 0 0 0.0013557845626193 0.999585019192862 0.998937828281888 0.999886920491758 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.His83Tyr Rv2752c_p.His83Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 142.93371627475 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.His86Arg Rv2752c_p.His86Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 5841 21462 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99995340819084 0.99974043469953 0.999998820398217 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 142.989195698265 1 319.5 2040 False False 7.3487416538264 0.382468755528661 432.333734199629 0 0 0.000631349913487419 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 889 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.His86fs Rv2752c_p.His86fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 2 2 5841 21461 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99990681638168 0.999663429698698 0.999988714832292 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 142.982548456817 1 883 2040 False False 3.67419962335216 0.266252080252227 50.6812073544246 0 0 0.000631349913487419 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 137.961202437293 1 457.5 1102 False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 0 0 0.0013557845626193 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.His86Pro Rv2752c_p.His86Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.His86Tyr Rv2752c_p.His86Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1645 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 895 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ile234Arg Rv2752c_p.Ile234Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ile234Val Rv2752c_p.Ile234Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ile248Thr Rv2752c_p.Ile248Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ile249Ser Rv2752c_p.Ile249Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ile24Val Rv2752c_p.Ile24Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1688 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 918 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ile287Val Rv2752c_p.Ile287Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ile303fs Rv2752c_p.Ile303fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1621 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 880 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ile303Ser Rv2752c_p.Ile303Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ile358dup Rv2752c_p.Ile358dup 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.56487735727821 0.58431003819195 215.5 2040 False False 0 0 5.56487735727821 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ile438Thr Rv2752c_p.Ile438Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ile43fs Rv2752c_p.Ile43fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1622 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0 0 0.00063124187675269 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ile43Ser Rv2752c_p.Ile43Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1616 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ile453Thr Rv2752c_p.Ile453Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ile527Thr Rv2752c_p.Ile527Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1686 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 915 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ile527Val Rv2752c_p.Ile527Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1637 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ile529fs Rv2752c_p.Ile529fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ile60fs Rv2752c_p.Ile60fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Leu109Trp Rv2752c_p.Leu109Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 4 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Leu111Arg Rv2752c_p.Leu111Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1771 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Leu111Pro Rv2752c_p.Leu111Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1735 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Leu166Arg Rv2752c_p.Leu166Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1670 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 906 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Leu166Pro Rv2752c_p.Leu166Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 2 5841 21461 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99990681638168 0.999663429698698 0.999988714832292 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 142.982548456817 1 883 2040 False False 3.67419962335216 0.266252080252227 50.6812073544246 0 0 0.000631349913487419 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Leu176Ser Rv2752c_p.Leu176Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 5839 21463 0.000684579839123737 0.000186555462570677 0.00175186028923716 1 0.999828143201531 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 1765 2040 False False Inf 2.42551325047942 Inf 0 0 0.000631566097937464 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 2716 9639 0.00147058823529411 0.000400826576335422 0.00376097173045195 1 0.999617369678334 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 965 1102 False False 0 0 0 0 0 0 0 Inf 2.34087544165449 Inf 0 0 0.00135728109876354 1 0.999617369678334 1 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Leu185Pro Rv2752c_p.Leu185Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Leu191Pro Rv2752c_p.Leu191Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Leu199Ser Rv2752c_p.Leu199Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 142.93371627475 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Leu200Arg Rv2752c_p.Leu200Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Leu222Arg Rv2752c_p.Leu222Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 142.93371627475 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 919 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Leu222Gln Rv2752c_p.Leu222Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0941866911272879 Inf 0.213982274957884 105.5 2040 False False Inf 0.0941866911272879 Inf 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Leu222Pro Rv2752c_p.Leu222Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Leu225Pro Rv2752c_p.Leu225Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 5841 21462 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99995340819084 0.99974043469953 0.999998820398217 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 142.989195698265 1 319.5 2040 False False 7.3487416538264 0.382468755528661 432.333734199629 0 0 0.000631349913487419 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Leu279Arg Rv2752c_p.Leu279Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Leu286Arg Rv2752c_p.Leu286Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1750 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 957 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Leu302_Thr305del Rv2752c_p.Leu302_Thr305del 2 inframe_deletion (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1596 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Leu315* Rv2752c_p.Leu315* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 142.93371627475 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Leu333fs Rv2752c_p.Leu333fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1597 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0 0 0.00063124187675269 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 868 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Leu333Pro Rv2752c_p.Leu333Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1677 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 909 1102 False False 0 0 0 0 0 0 0 0 0 8.57852451631077 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Leu336fs Rv2752c_p.Leu336fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Leu37Pro Rv2752c_p.Leu37Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1709 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 930 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Leu37Val Rv2752c_p.Leu37Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1678 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Leu381Arg Rv2752c_p.Leu381Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 5 5843 21458 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 8.89063948722811 1 883 2040 False False 0 0 4.0087500478358 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 5 2720 9634 0 0 0.00135528645033659 0.999481273991078 0.998789885214303 0.999831550309162 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 8.57674453615942 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 3.8675231049739 0 0 0.00135528645033659 0.999481273991078 0.998789885214303 0.999831550309162 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Leu382Pro Rv2752c_p.Leu382Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Leu384Arg Rv2752c_p.Leu384Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Leu384His Rv2752c_p.Leu384His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Leu384Val Rv2752c_p.Leu384Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1667 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Leu40fs Rv2752c_p.Leu40fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Leu41Ser Rv2752c_p.Leu41Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1759 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 960 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Leu41Trp Rv2752c_p.Leu41Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 142.93371627475 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Leu431Arg Rv2752c_p.Leu431Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5841 21463 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 1 0.999828143201531 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1671 2040 False False Inf 0.689929368506768 Inf 0 0 0.000631349913487419 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Leu452Ser Rv2752c_p.Leu452Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1679 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 910 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Leu452Val Rv2752c_p.Leu452Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1633 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 886 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Leu466Pro Rv2752c_p.Leu466Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1689 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 920 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Leu468Phe Rv2752c_p.Leu468Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Leu487Phe Rv2752c_p.Leu487Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 36 1 35 9 35 5834 21428 0.00154030463802841 0.000704559638966774 0.00292195530235611 0.998369286679401 0.997732795230871 0.998863893692721 0.204545454545454 0.098043176360591 0.353045056778249 0.0277777777777777 0.00070302520590478 0.145289264746853 0.0277777777777777 0.00070302520590478 0.145289264746853 0.104941476076203 0.00258745539892227 0.624672574939586 0.00348591554594976 32 2040 False False 0.944473284685831 0.398996653342076 2.00586157716761 0.000171379605826906 4.33894653949314e-06 0.000954492069833317 0.998369286679401 0.997732795230871 0.998863893692721 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 27 1 26 9 26 2711 9613 0.00330882352941176 0.00151408667811563 0.00627184495549277 0.997302624753605 0.996050200704984 0.998237251556842 0.257142857142857 0.124893971916761 0.432558849694038 0.037037037037037 0.000937257091944708 0.189705617413044 0.037037037037037 0.000937257091944708 0.189705617413044 0.136381692818432 0.003329161313476 0.831030286233627 0.0181762786201903 28 1102 False False 0 0 0 0 0 0 0 1.22743523536588 0.50544006828708 2.70702756048037 0.000368731563421828 9.33543134505048e-06 0.00205271001984139 0.997302624753605 0.996050200704984 0.998237251556842 45 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Leu492Arg Rv2752c_p.Leu492Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 142.93371627475 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 869 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 5 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Leu504fs Rv2752c_p.Leu504fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 142.964774304408 1 883 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0 0 0.00063124187675269 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 916 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Leu5Phe Rv2752c_p.Leu5Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1650 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Leu5Val Rv2752c_p.Leu5Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Leu61Pro Rv2752c_p.Leu61Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1760 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 961 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Leu77Pro Rv2752c_p.Leu77Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1761 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 962 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Leu93Arg Rv2752c_p.Leu93Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 2 8 5841 21455 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99962726552672 0.99926569731444 0.999839066414514 0.2 0.0252107263268333 0.556095462307641 0 0 0.602364635616474 0 0 0.369416647552819 0 0 5.56574555578022 0.584319372738884 235 2040 False False 0.91829310049649 0.0949729794213726 4.60322743360383 0 0 0.000631349913487419 0.99962726552672 0.99926569731444 0.999839066414514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 7 2720 9632 0 0 0.00135528645033659 0.999273783587509 0.99850429270085 0.999707975074577 0 0 0.409616397225003 0 0 0.707598226178713 0 0 0.409616397225003 0 0 8.57496455533825 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 2.45859411933764 0 0 0.00135528645033659 0.999273783587509 0.99850429270085 0.999707975074577 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Leu93Met Rv2752c_p.Leu93Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 2 2 5841 21461 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99990681638168 0.999663429698698 0.999988714832292 0.5 0.067585986488543 0.932414013511457 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5742605605944 1 883 2040 False False 3.67419962335216 0.266252080252227 50.6812073544246 0 0 0.000631349913487419 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 2719 9637 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999792509596431 0.999250676427901 0.999974870961701 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8778635755656 1 457.5 1102 False False 0 0 0 0 0 0 0 1.77215888194189 0.0300270423699391 34.0580978516331 0 0 0.0013557845626193 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Leu93Pro Rv2752c_p.Leu93Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5841 21463 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 1 0.999828143201531 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1762 2040 False False Inf 0.689929368506768 Inf 0 0 0.000631349913487419 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 2718 9639 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 1 0.999617369678334 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 963 1102 False False 0 0 0 0 0 0 0 Inf 0.665658435310444 Inf 0 0 0.00135628304118183 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Leu94Arg Rv2752c_p.Leu94Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1772 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0 0 0.00063124187675269 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 968 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Leu94Phe Rv2752c_p.Leu94Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Leu94Pro Rv2752c_p.Leu94Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1751 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Lys115Glu Rv2752c_p.Lys115Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Lys172Glu Rv2752c_p.Lys172Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 4 5841 21459 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99981363276336 0.999522895233871 0.999949218940757 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.975 0 0 0.602364635616474 0 0 142.969253969769 1 883 2040 False False 1.83692860811504 0.166109303397098 12.8208569329986 0 0 0.000631349913487419 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 2 2718 9637 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 0.999792509596431 0.999250676427901 0.999974870961701 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 137.997564138244 1 457.5 1102 False False 0 0 0 0 0 0 0 3.54562178072111 0.256860512408561 48.9209196354209 0 0 0.00135628304118183 0.999792509596431 0.999250676427901 0.999974870961701 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Lys357Thr Rv2752c_p.Lys357Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 7 5843 21456 0 0 0.000631133876986172 0.99967385733588 0.999328137654343 0.999868864001311 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1710 2040 False False 0 0 2.5485399472607 0 0 0.000631133876986172 0.99967385733588 0.999328137654343 0.999868864001311 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 2720 9633 0 0 0.00135528645033659 0.999377528789293 0.998645638320949 0.999771530871485 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 931 1102 False False 0 0 0 0 0 0 0 0 0 3.00974784500922 0 0 0.00135528645033659 0.999377528789293 0.998645638320949 0.999771530871485 8 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Lys435Glu Rv2752c_p.Lys435Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 12 0 12 2 20 5841 21443 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.999068163816801 0.998561219655491 0.999430720271997 0.0909090909090909 0.0112055860241509 0.291612741553933 0 0 0.264648469397051 0 0 0.168433470983085 0 0 1.32169614389432 0.0822876308107608 69 2040 False False 0.367111795925355 0.0415943473659495 1.5120327780201 0 0 0.000631349913487419 0.999068163816801 0.998561219655491 0.999430720271997 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 0 15 2720 9624 0 0 0.00135528645033659 0.998443821973233 0.997434617850146 0.99912876560277 0 0 0.218019360910534 0 0 0.369416647552819 0 0 0.218019360910534 0 0 2.07431525375905 0.213281873831733 59 1102 False False 0 0 0 0 0 0 0 0 0 0.987286325703696 0 0 0.00135528645033659 0.998443821973233 0.997434617850146 0.99912876560277 31 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Lys446fs Rv2752c_p.Lys446fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 142.93371627475 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Lys502fs Rv2752c_p.Lys502fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1638 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Lys510Gln Rv2752c_p.Lys510Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 8 5843 21455 0 0 0.000631133876986172 0.99962726552672 0.99926569731444 0.999839066414514 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1728 2040 False False 0 0 2.15187999193565 0 0 0.000631133876986172 0.99962726552672 0.99926569731444 0.999839066414514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 8 2720 9631 0 0 0.00135528645033659 0.999170038385724 0.99836530325407 0.99964161554927 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 943 1102 False False 0 0 0 0 0 0 0 0 0 2.07582396316403 0 0 0.00135528645033659 0.999170038385724 0.99836530325407 0.99964161554927 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Met1? Rv2752c_p.Met1? 2 start_lost (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1721 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Met188Lys Rv2752c_p.Met188Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 5843 21458 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.0087500478358 0.59157266040946 268 2040 False False 0 0 4.0087500478358 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Met270Arg Rv2752c_p.Met270Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1672 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 907 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Met312Ile Rv2752c_p.Met312Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 9 5843 21454 0 0 0.000631133876986172 0.99958067371756 0.999204138016772 0.999808239967157 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1653 2040 False False 0 0 1.86084922251217 0 0 0.000631133876986172 0.99958067371756 0.999204138016772 0.999808239967157 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Met312Val Rv2752c_p.Met312Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 16 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Met318_Arg320del Rv2752c_p.Met318_Arg320del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 3 0 3 2 3 5841 21460 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99986022457252 0.999591571764338 0.999971174018896 0.4 0.0527449505263169 0.853367200365326 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89451223755799 1 883 2040 False False 2.44935227986075 0.204519727205419 21.3860749684357 0 0 0.000631349913487419 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Met31Ile Rv2752c_p.Met31Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 125 4 121 23 179 5820 21284 0.00393633407496149 0.00249688481990031 0.00590061412371869 0.991660066160369 0.990351155618519 0.992833052486033 0.113861386138613 0.073563114025432 0.16593764144345 0.032 0.00878643301350049 0.0799063775335207 0.0218579234972677 0.00598691324612589 0.0550167142784731 0.120894038794694 0.032403664041880303 0.317827803098023 8.86579514430974e-09 13 2040 True False 0.469899594924072 0.290119338148044 0.728430903735384 0.000686813186813186 0.000187164173986795 0.00175757242990564 0.991660066160369 0.990351155618519 0.992833052486033 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 20 0 20 5 25 2715 9614 0.00183823529411764 0.000597130943349739 0.00428457163587036 0.997406369955389 0.996173655269493 0.998320857770214 0.166666666666666 0.0564216964680715 0.347211698834143 0 0 0.168433470983085 0 0 0.137185171530712 0 0 0.717849092536934 0.0122869431328933 25 1102 False False 0 0 0 0 0 0 0 0.708213627992633 0.21154383883081 1.88600727289313 0 0 0.00135778067859282 0.997406369955389 0.996173655269493 0.998320857770214 178 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Met394Arg Rv2752c_p.Met394Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 142.93371627475 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 137.896313968788 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Met394fs Rv2752c_p.Met394fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1592 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Met447Thr Rv2752c_p.Met447Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 142.964774304408 1 883 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0 0 0.00063124187675269 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 5 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Phe107Pro Rv2752c_p.Phe107Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1623 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 881 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Phe125Leu Rv2752c_p.Phe125Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1617 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Phe139fs Rv2752c_p.Phe139fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Phe139Val Rv2752c_p.Phe139Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Phe144Ser Rv2752c_p.Phe144Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Phe238Ser Rv2752c_p.Phe238Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 3 5841 21460 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99986022457252 0.999591571764338 0.999971174018896 0.4 0.0527449505263169 0.853367200365326 0 0 0.975 0 0 0.707598226178713 0 0 142.975901213985 1 883 2040 False False 2.44935227986075 0.204519727205419 21.3860749684357 0 0 0.000631349913487419 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 2718 9638 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 0.999896254798215 0.999422105789591 0.999997373402351 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 138.011851332821 1 457.5 1102 False False 0 0 0 0 0 0 0 7.09197939661515 0.368993183584618 417.296682266591 0 0 0.00135628304118183 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Phe349fs Rv2752c_p.Phe349fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Phe34fs Rv2752c_p.Phe34fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1766 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 966 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Phe383Leu Rv2752c_p.Phe383Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Phe383Ser Rv2752c_p.Phe383Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Phe448Leu Rv2752c_p.Phe448Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1763 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Phe49Leu Rv2752c_p.Phe49Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Pro101Ala Rv2752c_p.Pro101Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 9 0 9 0 16 5843 21447 0 0 0.000631133876986172 0.99925453105344 0.998789686679379 0.999573841954248 0 0 0.205907214207822 0 0 0.336267116879942 0 0 0.205907214207822 0 0 1.86024211899175 0.219695758354963 138 2040 False False 0 0 0.952125276634789 0 0 0.000631133876986172 0.99925453105344 0.998789686679379 0.999573841954248 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 0 15 2720 9624 0 0 0.00135528645033659 0.998443821973233 0.997434617850146 0.99912876560277 0 0 0.218019360910534 0 0 0.336267116879942 0 0 0.218019360910534 0 0 1.79381257490638 0.221123931660007 90 1102 False False 0 0 0 0 0 0 0 0 0 0.987286325703696 0 0 0.00135528645033659 0.998443821973233 0.997434617850146 0.99912876560277 9 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Pro101Leu Rv2752c_p.Pro101Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1639 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 890 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Pro10Arg Rv2752c_p.Pro10Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1593 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Pro123Leu Rv2752c_p.Pro123Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 60 179 5783 21284 0.010268697586856 0.00784498888209156 0.0131983294600593 0.991660066160369 0.990351155618519 0.992833052486033 0.251046025104602 0.197378777568547 0.311001922888795 NA NA NA 0 0 0.020397366050582 NA NA NA NA 1742 2040 False True 1.23366793636134 0.903737413950842 1.66392365388517 0 0 0.000637679952763881 0.991660066160369 0.990351155618519 0.992833052486033 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 13 65 2707 9574 0.00477941176470588 0.00254721544199456 0.00815907242338076 0.993256561884012 0.991412900017842 0.994791813676927 0.166666666666666 0.0918384413360962 0.26812767237673 NA NA NA 0 0 0.0551716343188133 NA NA NA NA 951 1102 False True 0 1 1 0 0 0 0 0.70735131141485 0.357091058548465 1.29816675394395 0 0 0.00136179059585261 0.993256561884012 0.991412900017842 0.994791813676927 251 5) Not assoc w R New NotAwR yes 5 +Levofloxacin Rv2752c p.Pro123Ser Rv2752c_p.Pro123Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1716 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 936 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Pro182Leu Rv2752c_p.Pro182Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1773 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Pro186Ser Rv2752c_p.Pro186Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 142.93371627475 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Pro209Ser Rv2752c_p.Pro209Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Pro213Ala Rv2752c_p.Pro213Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Pro213fs Rv2752c_p.Pro213fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Pro220Ala Rv2752c_p.Pro220Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1743 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Pro220fs Rv2752c_p.Pro220fs 2 frameshift (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 5843 21458 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.0087500478358 0.59157266040946 268 2040 False False 0 0 4.0087500478358 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 2720 9634 0 0 0.00135528645033659 0.999481273991078 0.998789885214303 0.999831550309162 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 3.8675231049739 0.592777991359257 136 1102 False False 0 0 0 0 0 0 0 0 0 3.8675231049739 0 0 0.00135528645033659 0.999481273991078 0.998789885214303 0.999831550309162 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Pro220Leu Rv2752c_p.Pro220Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1624 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Pro390Arg Rv2752c_p.Pro390Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1695 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Pro390Leu Rv2752c_p.Pro390Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 81 0 81 1 84 5842 21379 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.996086288030564 0.99515681703187 0.996877105141096 0.0117647058823529 0.000297812209658448 0.0638128785535283 0 0 0.0445202624563217 0 0 0.042964919629565 0 0 0.170588557635397 4.85297374484221e-09 12 2040 True False 0.0435658857860158 0.00109423988791748 0.249565724538219 0 0 0.00063124187675269 0.996086288030564 0.99515681703187 0.996877105141096 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 14 0 14 0 14 2720 9625 0 0 0.00135528645033659 0.998547567175018 0.997564264113055 0.999205721130751 0 0 0.231635761650116 0 0 0.231635761650116 0 0 0.231635761650116 0 0 1.06763707910471 0.0502793469156406 38 1102 False False 0 0 0 0 0 0 0 0 0 1.06763707910471 0 0 0.00135528645033659 0.998547567175018 0.997564264113055 0.999205721130751 35 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Pro395Ser Rv2752c_p.Pro395Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1711 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 932 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Pro416Leu Rv2752c_p.Pro416Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Pro443Leu Rv2752c_p.Pro443Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Pro490Arg Rv2752c_p.Pro490Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5841 21463 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 1 0.999828143201531 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1640 2040 False False Inf 0.689929368506768 Inf 0 0 0.000631349913487419 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 2718 9639 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 1 0.999617369678334 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 891 1102 False False 0 0 0 0 0 0 0 Inf 0.665658435310444 Inf 0 0 0.00135628304118183 1 0.999617369678334 1 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Pro490fs Rv2752c_p.Pro490fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Pro549Gln Rv2752c_p.Pro549Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Pro549Ser Rv2752c_p.Pro549Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Pro553Leu Rv2752c_p.Pro553Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Pro55Ser Rv2752c_p.Pro55Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 142.964774304408 1 883 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0 0 0.00063124187675269 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Pro62Leu Rv2752c_p.Pro62Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1598 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Pro6fs Rv2752c_p.Pro6fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 5840 21463 0.000513434879342803 0.000105895133877182 0.00149973424244328 1 0.999828143201531 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1722 2040 False False Inf 1.51820267072123 Inf 0 0 0.000631457987209345 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 941 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Pro7fs Rv2752c_p.Pro7fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1690 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Pro7Gln Rv2752c_p.Pro7Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Pro8fs Rv2752c_p.Pro8fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Pro8Ser Rv2752c_p.Pro8Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Pro91Leu Rv2752c_p.Pro91Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 63 1 62 4 68 5839 21395 0.000684579839123737 0.000186555462570677 0.00175186028923716 0.996831756977123 0.995985201373089 0.997538920884996 0.0555555555555555 0.0153425371111305 0.136178649312924 0.0158730158730158 0.000401789229084887 0.085295709299263 0.0144927536231884 0.000366857444740834 0.0781235357401634 0.0590992713069515 0.00147667592381259 0.341856007787399 7.98065116989254e-06 22 2040 True False 0.215538518884176 0.0570503276589697 0.578025046706764 0.000171232876712328 4.33523169605623e-06 0.00095367518755974 0.996831756977123 0.995985201373089 0.997538920884996 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 59 1 58 2 63 2718 9576 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 0.993464052287581 0.991645327370637 0.994974050365158 0.0307692307692307 0.00374826221951288 0.106770320574398 0.0169491525423728 0.000429023332723594 0.0908559328866492 0.015625 0.000395512514050664 0.0840103264343536 0.0607444622059831 0.00151573823870341 0.352479443647043 1.11157813561865e-05 12 1102 True False 0 0 0 0 0 0 0 0.111846946284032 0.0132649345767201 0.421673918908088 0.000367782272894446 9.31139761383543e-06 0.00204742980952803 0.993464052287581 0.991645327370637 0.994974050365158 32 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ser133fs Rv2752c_p.Ser133fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1625 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ser149Phe Rv2752c_p.Ser149Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 3 5842 21460 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99986022457252 0.999591571764338 0.999971174018896 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1696 2040 False False 1.22446650690402 0.0233203404016305 15.2512395040111 0 0 0.00063124187675269 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ser189Leu Rv2752c_p.Ser189Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ser216fs Rv2752c_p.Ser216fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ser240Phe Rv2752c_p.Ser240Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ser240Pro Rv2752c_p.Ser240Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1736 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 948 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ser260* Rv2752c_p.Ser260* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ser284fs Rv2752c_p.Ser284fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ser284Pro Rv2752c_p.Ser284Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1697 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 922 1102 False False 0 0 0 0 0 0 0 0 0 8.57852451631077 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ser313Leu Rv2752c_p.Ser313Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 142.964774304408 1 883 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0 0 0.00063124187675269 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 933 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ser313Pro Rv2752c_p.Ser313Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 3.67374186922286 0.0467931454016956 287.712465214691 0.382182295738733 180 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ser313Trp Rv2752c_p.Ser313Trp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5841 21463 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 1 0.999828143201531 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1700 2040 False False Inf 0.689929368506768 Inf 0 0 0.000631349913487419 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ser319Pro Rv2752c_p.Ser319Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1657 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ser325Arg Rv2752c_p.Ser325Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ser337Leu Rv2752c_p.Ser337Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 2 5842 21461 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99990681638168 0.999663429698698 0.999988714832292 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1634 2040 False False 1.83678534748373 0.0311281139040964 35.2896458967866 0 0 0.00063124187675269 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 887 1102 False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 0 0 0.0013557845626193 0.999896254798215 0.999422105789591 0.999997373402351 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ser337Pro Rv2752c_p.Ser337Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ser337Trp Rv2752c_p.Ser337Trp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1767 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ser338Leu Rv2752c_p.Ser338Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1635 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ser338Pro Rv2752c_p.Ser338Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ser339del Rv2752c_p.Ser339del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 3 0 3 5 5 5838 21458 0.000855724798904672 0.00027790803803495 0.00199583691247191 0.9997670409542 0.99945643574724 0.999924354643808 0.5 0.187086028447398 0.812913971552601 0 0 0.707598226178713 0 0 0.521823750104981 0 0 8.8982534685443 1 1414.5 2040 False False 3.67557382665296 0.845546036055931 15.9829201352399 0 0 0.000631674245690789 0.9997670409542 0.99945643574724 0.999924354643808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 5 4 2715 9635 0.00183823529411764 0.000597130943349739 0.00428457163587036 0.999585019192862 0.998937828281888 0.999886920491758 0.555555555555555 0.212008506778868 0.863004337734833 0 0 0.841886116991581 0 0 0.602364635616474 0 0 18.9017535191632 1 457.5 1102 False False 0 0 0 0 0 0 0 4.43600368324125 0.953932677572901 22.3656173042633 0 0 0.00135778067859282 0.999585019192862 0.998937828281888 0.999886920491758 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ser339Pro Rv2752c_p.Ser339Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ser339* Rv2752c_p.Ser339* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ser356Cys Rv2752c_p.Ser356Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89146792489366 1 319.5 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.57852451631077 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 8.57852451631077 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ser356Pro Rv2752c_p.Ser356Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 1 6 1 6 5842 21457 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99972044914504 0.999391635540124 0.999897403075094 0.142857142857142 0.00361029686190058 0.578723197043195 0.142857142857142 0.00361029686190058 0.578723197043195 0.142857142857142 0.00361029686190058 0.578723197043195 0.612147666324318 0.0133096260827154 5.04744841661085 1 883 2040 False False 0.612147666324318 0.0133096260827154 5.04744841661085 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99972044914504 0.999391635540124 0.999897403075094 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 1 6 1 6 2719 9633 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999377528789293 0.998645638320949 0.999771530871485 0.142857142857142 0.00361029686190058 0.578723197043195 0.142857142857142 0.00361029686190058 0.578723197043195 0.142857142857142 0.00361029686190058 0.578723197043195 0.590474439132033 0.0128360606385712 4.87020043259644 1 147 1102 False False 0 0 0 0 0 0 0 0.590474439132033 0.0128360606385712 4.87020043259644 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999377528789293 0.998645638320949 0.999771530871485 5 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ser373Phe Rv2752c_p.Ser373Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1774 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 969 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ser373Tyr Rv2752c_p.Ser373Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 142.93371627475 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ser419* Rv2752c_p.Ser419* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ser428Gly Rv2752c_p.Ser428Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ser437Gly Rv2752c_p.Ser437Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 142.964774304408 1 883 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0 0 0.00063124187675269 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 137.961202437293 1 457.5 1102 False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 0 0 0.0013557845626193 0.999896254798215 0.999422105789591 0.999997373402351 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ser439Phe Rv2752c_p.Ser439Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 4 5842 21459 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99981363276336 0.999522895233871 0.999949218940757 0.2 0.00505076337946806 0.716417936118089 0 0 0.975 0 0 0.602364635616474 0 0 142.944835974172 1 883 2040 False False 0.918307086614173 0.0186435710006194 9.27999188457764 0 0 0.00063124187675269 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 946 1102 False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 0 0 0.0013557845626193 0.999896254798215 0.999422105789591 0.999997373402351 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ser470Leu Rv2752c_p.Ser470Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1658 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ser470Pro Rv2752c_p.Ser470Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ser494Leu Rv2752c_p.Ser494Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ser498Ala Rv2752c_p.Ser498Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1701 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 923 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ser498fs Rv2752c_p.Ser498fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ser498Pro Rv2752c_p.Ser498Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 28 8 5815 21455 0.00479205887386616 0.00318657959282004 0.00691846697366604 0.99962726552672 0.99926569731444 0.999839066414514 0.777777777777777 0.608482350842618 0.898849469655087 0 0 0.521823750104981 0 0 0.369416647552819 0 0 4.02749348399021 0.591443049315068 244 2040 False False 12.9135855546001 5.72964941591209 32.7998597362779 0 0 0.000634171906893363 0.99962726552672 0.99926569731444 0.999839066414514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 7 3 2713 9636 0.0025735294117647 0.0010352988504908 0.00529522151968195 0.999688764394646 0.999090709558603 0.999935811136198 0.7 0.347547149940002 0.933260488822265 0 0 0.841886116991581 0 0 0.707598226178713 0 0 18.9176501413366 1 457.5 1102 False False 0 0 0 0 0 0 0 8.28750460744563 1.89007708426738 49.7180602938531 0 0 0.00135878094235795 0.999688764394646 0.999090709558603 0.999935811136198 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Ter559Tyrext*? Rv2752c_p.Ter559Tyrext*? 2 stop_lost (see "Genomic_coordinates" sheet) 1 1 0 1 9 1 5834 21462 0.00154030463802841 0.000704559638966774 0.00292195530235611 0.99995340819084 0.99974043469953 0.999998820398217 0.9 0.554983882971804 0.997471421455538 0 0 0.975 0 0 0.975 0 0 143.160379349492 1 883 2040 False False 33.1090161124442 4.58571372485259 1440.26357420393 0 0 0.000632107207336799 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 8 1 2712 9638 0.00294117647058823 0.00127061997302132 0.00578702225151795 0.999896254798215 0.999422105789591 0.999997373402351 0.888888888888888 0.517503485082663 0.9971908632534 0 0 0.975 0 0 0.975 0 0 138.316527396334 1 457.5 1102 False False 0 0 0 0 0 0 0 28.4306784660766 3.80777385352131 1253.34666082934 0 0 0.00135928162710748 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Thr160Asn Rv2752c_p.Thr160Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1659 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 902 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Thr164fs Rv2752c_p.Thr164fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1654 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Thr183Ile Rv2752c_p.Thr183Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1599 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Thr204Arg Rv2752c_p.Thr204Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Thr329Ala Rv2752c_p.Thr329Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Thr329Pro Rv2752c_p.Thr329Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 7 5843 21456 0 0 0.000631133876986172 0.99967385733588 0.999328137654343 0.999868864001311 0 0 0.409616397225003 0 0 0.521823750104981 0 0 0.409616397225003 0 0 4.00837643862237 0.591575322438888 280 2040 False False 0 0 2.5485399472607 0 0 0.000631133876986172 0.99967385733588 0.999328137654343 0.999868864001311 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 137.896313968788 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Thr32Arg Rv2752c_p.Thr32Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1737 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Thr364Ile Rv2752c_p.Thr364Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89146792489366 1 319.5 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Thr364Pro Rv2752c_p.Thr364Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Thr461Ile Rv2752c_p.Thr461Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 2 3 5841 21460 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99986022457252 0.999591571764338 0.999971174018896 0.4 0.0527449505263169 0.853367200365326 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89451223755799 1 883 2040 False False 2.44935227986075 0.204519727205419 21.3860749684357 0 0 0.000631349913487419 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 2 2 2718 9637 0.000735294117647058 8.90599364723169e-05 0.00265358538902645 0.999792509596431 0.999250676427901 0.999974870961701 0.5 0.067585986488543 0.932414013511457 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8848089598515 1 457.5 1102 False False 0 0 0 0 0 0 0 3.54562178072111 0.256860512408561 48.9209196354209 0 0 0.00135628304118183 0.999792509596431 0.999250676427901 0.999974870961701 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Thr461Pro Rv2752c_p.Thr461Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 5841 21463 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 1 0.999828143201531 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1691 2040 False False Inf 0.689929368506768 Inf 0 0 0.000631349913487419 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Thr476fs Rv2752c_p.Thr476fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1588 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Thr476Pro Rv2752c_p.Thr476Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1608 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 873 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Thr536Ser Rv2752c_p.Thr536Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 142.93371627475 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Thr544fs Rv2752c_p.Thr544fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Thr554Pro Rv2752c_p.Thr554Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Thr80Ala Rv2752c_p.Thr80Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 5 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Thr80Ile Rv2752c_p.Thr80Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 11 0 11 0 11 5843 21452 0 0 0.000631133876986172 0.99948749009924 0.999083163687746 0.999744130025508 0 0 0.284914152918154 0 0 0.284914152918154 0 0 0.284914152918154 0 0 1.46336646580729 0.135836573499167 82.5 2040 False False 0 0 1.46336646580729 0 0 0.000631133876986172 0.99948749009924 0.999083163687746 0.999744130025508 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 0 11 0 11 2720 9628 0 0 0.00135528645033659 0.998858802780371 0.997959002506684 0.999430185159088 0 0 0.284914152918154 0 0 0.284914152918154 0 0 0.284914152918154 0 0 1.41143234851738 0.137135921280285 52 1102 False False 0 0 0 0 0 0 0 0 0 1.41143234851738 0 0 0.00135528645033659 0.998858802780371 0.997959002506684 0.999430185159088 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Thr80Pro Rv2752c_p.Thr80Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1775 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Trp400Arg Rv2752c_p.Trp400Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 142.964774304408 1 883 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0 0 0.00063124187675269 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 866 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Trp400* Rv2752c_p.Trp400* 2 stop_gained (see "Genomic_coordinates" sheet) 1 12 0 12 0 12 5843 21451 0 0 0.000631133876986172 0.99944089829008 0.999023565718772 0.999711071680148 0 0 0.264648469397051 0 0 0.264648469397051 0 0 0.264648469397051 0 0 1.32173650369041 0.0822889989657442 70 2040 False False 0 0 1.32173650369041 0 0 0.000631133876986172 0.99944089829008 0.999023565718772 0.999711071680148 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.57852451631077 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 8.57852451631077 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 15 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Trp540Arg Rv2752c_p.Trp540Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 5842 21461 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99990681638168 0.999663429698698 0.999988714832292 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5709198500876 1 883 2040 False False 1.83678534748373 0.0311281139040964 35.2896458967866 0 0 0.00063124187675269 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 137.961202437293 1 457.5 1102 False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 0 0 0.0013557845626193 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Trp540fs Rv2752c_p.Trp540fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1776 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Trp540Gly Rv2752c_p.Trp540Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Trp540* Rv2752c_p.Trp540* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1651 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Tyr143Cys Rv2752c_p.Tyr143Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1600 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Tyr143* Rv2752c_p.Tyr143* 2 stop_gained (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1687 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Tyr159* Rv2752c_p.Tyr159* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Tyr385Asp Rv2752c_p.Tyr385Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 7 5 5836 21458 0.00119801471846654 0.000481795418920789 0.00246680058103687 0.9997670409542 0.99945643574724 0.999924354643808 0.583333333333333 0.276669685682105 0.848347770191569 0.333333333333333 0.00840375865961264 0.905700675949754 0.166666666666666 0.00421074451448947 0.641234578997674 1.83841672378341 0.0311557556096116 35.2956693384124 0.514117328733313 189 2040 False False 5.14756682659355 1.40568884897439 20.5740799097861 0.000171320884015761 4.33745983840372e-06 0.000954165149050869 0.9997670409542 0.99945643574724 0.999924354643808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 4 4 2716 9635 0.00147058823529411 0.000400826576335422 0.00376097173045195 0.999585019192862 0.998937828281888 0.999886920491758 0.5 0.157012770487058 0.842987229512941 0.5 0.012579117093425 0.987420882906574 0.2 0.00505076337946806 0.716417936118089 3.54749631811487 0.0451763010461592 277.864916301821 0.391530539035429 98 1102 False False 0 0 0 0 0 0 0 3.54749631811487 0.660201236530047 19.0539091964982 0.000368052999631947 9.31825175754594e-06 0.0020489356671006 0.999585019192862 0.998937828281888 0.999886920491758 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Tyr545Cys Rv2752c_p.Tyr545Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Val102Ala Rv2752c_p.Val102Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1680 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 911 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Val112_Ala113del Rv2752c_p.Val112_Ala113del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Val124Met Rv2752c_p.Val124Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Val128Gly Rv2752c_p.Val128Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1768 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Val138Ala Rv2752c_p.Val138Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1636 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Val138Leu Rv2752c_p.Val138Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Val146dup Rv2752c_p.Val146dup 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1752 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Val146fs Rv2752c_p.Val146fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 19.5666713375759 1 883 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 13 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Val211Ile Rv2752c_p.Val211Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1744 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 952 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Val218Leu Rv2752c_p.Val218Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 1 8 5842 21455 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99962726552672 0.99926569731444 0.999839066414514 0.111111111111111 0.00280913674659921 0.482496514917337 0 0 0.4592581264399 0 0 0.369416647552819 0 0 3.12031349628375 0.352578235518943 156 2040 False False 0.45906795617939 0.0103475211102756 3.425357676166 0 0 0.00063124187675269 0.99962726552672 0.99926569731444 0.999839066414514 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 7 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Val233Gly Rv2752c_p.Val233Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.89146792489366 1 319.5 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.57852451631077 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 8.57852451631077 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Val245Ile Rv2752c_p.Val245Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 5 5843 21458 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 8.89063948722811 1 883 2040 False False 0 0 4.0087500478358 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Val259Ala Rv2752c_p.Val259Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Val272Ala Rv2752c_p.Val272Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 1 6 5842 21457 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99972044914504 0.999391635540124 0.999897403075094 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.521823750104981 0 0 0.4592581264399 0 0 4.00924954320777 0.591569100579173 257.5 2040 False False 0.612147666324318 0.0133096260827154 5.04744841661085 0 0 0.00063124187675269 0.99972044914504 0.999391635540124 0.999897403075094 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 14 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Val281Glu Rv2752c_p.Val281Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Val300Ala Rv2752c_p.Val300Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 57 1 56 20 92 5823 21371 0.00342289919561868 0.00209201097268901 0.00528146372285452 0.995713553557284 0.994745606710356 0.996543162137372 0.178571428571428 0.112622947346299 0.262227192897656 0.0175438596491228 0.000444073440089392 0.0939168418919107 0.010752688172043 0.000272197442007138 0.0584581645143803 0.0655375236132577 0.00163431675527423 0.380610652985792 2.95244372860325e-05 23 2040 True False 0.797848113552703 0.465408437297195 1.30582577996093 0.000171703296703296 4.34714164735598e-06 0.000956294146097759 0.995713553557284 0.994745606710356 0.996543162137372 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 40 1 39 16 71 2704 9568 0.00588235294117647 0.00336589967267386 0.00953503998064353 0.992634090673306 0.990717861362013 0.994242811779389 0.183908045977011 0.108932558989167 0.281404200647585 0.025 0.000632744932049419 0.131585858482765 0.0138888888888888 0.000351574405233597 0.0749713108539191 0.0907297830374753 0.00224350666735478 0.536746921582166 0.000899021196451549 18 1102 False False 0 0 0 0 0 0 0 0.797399783315276 0.431836963460266 1.38851277572492 0.000369685767097966 9.35958946468046e-06 0.0020580175353164 0.992634090673306 0.990717861362013 0.994242811779389 103 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Val335Met Rv2752c_p.Val335Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 5843 21458 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.0087500478358 0.59157266040946 268 2040 False False 0 0 4.0087500478358 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Val348fs Rv2752c_p.Val348fs 2 frameshift (see "Genomic_coordinates" sheet) 1 33 1 32 21 37 5822 21426 0.00359404415539962 0.00222610454413391 0.00548865843522298 0.998276103061081 0.997624610249359 0.998785935986848 0.362068965517241 0.239920819406301 0.498821020491002 0.0303030303030303 0.000766912075048109 0.157593972272496 0.0263157894736842 0.000666036204202366 0.13809902979242 0.115005582274132 0.00282792409071814 0.688808357717875 0.00527397294635308 33 2040 False False 2.08875003481667 1.16061802938027 3.6660032420388 0.000171732783788425 4.34788819246965e-06 0.000956458308689881 0.998276103061081 0.997624610249359 0.998785935986848 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 34 1 33 20 37 2700 9602 0.00735294117647058 0.00449698352187646 0.0113332827880076 0.996161427533976 0.994712877434656 0.997295894108395 0.350877192982456 0.229145597168238 0.48868661750685 0.0294117647058823 0.00074436423469026 0.153267669560317 0.0263157894736842 0.000666036204202366 0.13809902979242 0.107766554433221 0.00265208261374347 0.644416441666699 0.00333035009184989 22 1102 False False 0 0 0 0 0 0 0 1.92232232232232 1.0552270596626 3.40513854240887 0.000370233246945575 9.37345032450825e-06 0.00206106274239273 0.996161427533976 0.994712877434656 0.997295894108395 15 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Val351Ala Rv2752c_p.Val351Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 5 5843 21458 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1729 2040 False False 0 0 4.0087500478358 0 0 0.000631133876986172 0.9997670409542 0.99945643574724 0.999924354643808 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Val370Gly Rv2752c_p.Val370Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1681 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 912 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Val372fs Rv2752c_p.Val372fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1682 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Val388fs Rv2752c_p.Val388fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1660 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Val415Gly Rv2752c_p.Val415Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1702 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 924 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Val415Ile Rv2752c_p.Val415Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Val432fs Rv2752c_p.Val432fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1692 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Val457Ile Rv2752c_p.Val457Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Val473Ala Rv2752c_p.Val473Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1641 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 892 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Val473Gly Rv2752c_p.Val473Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Val475Ala Rv2752c_p.Val475Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Val477Ile Rv2752c_p.Val477Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 19.5675802888319 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Val47fs Rv2752c_p.Val47fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1754 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Val47Met Rv2752c_p.Val47Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Val511Gly Rv2752c_p.Val511Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 5843 21460 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 19.5666713375759 1 883 2040 False False 0 0 8.89146792489366 0 0 0.000631133876986172 0.99986022457252 0.999591571764338 0.999971174018896 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 2720 9637 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 18.8709233025667 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 18.8709233025667 0 0 0.00135528645033659 0.999792509596431 0.999250676427901 0.999974870961701 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Val533Ala Rv2752c_p.Val533Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 4 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Val533Gly Rv2752c_p.Val533Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 2 5841 21461 0.000342289919561868 4.14555856232918e-05 0.00123591619157378 0.99990681638168 0.999663429698698 0.999988714832292 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 142.982548456817 1 883 2040 False False 3.67419962335216 0.266252080252227 50.6812073544246 0 0 0.000631349913487419 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 2719 9637 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999792509596431 0.999250676427901 0.999974870961701 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 137.946920474639 1 457.5 1102 False False 0 0 0 0 0 0 0 1.77215888194189 0.0300270423699391 34.0580978516331 0 0 0.0013557845626193 0.999792509596431 0.999250676427901 0.999974870961701 2 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Val537Phe Rv2752c_p.Val537Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 3.67374186922286 0.0467931454016956 287.712465214691 0.382182295738733 180 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Val552Ala Rv2752c_p.Val552Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 5843 21462 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 0 0 0.975 0 0 0.975 0 0 0.975 0 0 142.940361251077 1 883 2040 False False 0 0 142.940361251077 0 0 0.000631133876986172 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Val555Ala Rv2752c_p.Val555Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 5843 21461 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 142.93371627475 1 883 2040 False False 0 0 19.5675802888319 0 0 0.000631133876986172 0.99990681638168 0.999663429698698 0.999988714832292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Val555Gly Rv2752c_p.Val555Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 5842 21463 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 1 0.999828143201531 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1642 2040 False False Inf 0.0941866911272879 Inf 0 0 0.00063124187675269 1 0.999828143201531 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 2719 9639 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 1 0.999617369678334 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 893 1102 False False 0 0 0 0 0 0 0 Inf 0.0908652957857324 Inf 0 0 0.0013557845626193 1 0.999617369678334 1 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Val558fs Rv2752c_p.Val558fs 2 frameshift (see "Genomic_coordinates" sheet) 1 10 0 10 0 10 5843 21453 0 0 0.000631133876986172 0.9995340819084 0.999143327515781 0.999776552276323 0 0 0.30849710781876 0 0 0.30849710781876 0 0 0.30849710781876 0 0 1.63855069807244 0.13288791583727 79 2040 False False 0 0 1.63855069807244 0 0 0.000631133876986172 0.9995340819084 0.999143327515781 0.999776552276323 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 2720 9636 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 8.57852451631077 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 8.57852451631077 0 0 0.00135528645033659 0.999688764394646 0.999090709558603 0.999935811136198 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Val558Gly Rv2752c_p.Val558Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.56487735727821 0.58431003819195 215.5 2040 False False 0 0 5.56487735727821 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 2720 9638 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 0 0 0.975 0 0 0.975 0 0 0.975 0 0 137.910590703348 1 457.5 1102 False False 0 0 0 0 0 0 0 0 0 137.910590703348 0 0 0.00135528645033659 0.999896254798215 0.999422105789591 0.999997373402351 1 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Val57Gly Rv2752c_p.Val57Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 5842 21462 0.000171144959780934 4.33300584171578e-06 0.000953185728998403 0.99995340819084 0.99974043469953 0.999998820398217 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1643 2040 False False 3.67374186922286 0.0467931454016956 287.712465214691 0 0 0.00063124187675269 0.99995340819084 0.99974043469953 0.999998820398217 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 2719 9638 0.000367647058823529 9.30797432182125e-06 0.00204667771047986 0.999896254798215 0.999422105789591 0.999997373402351 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 894 1102 False False 0 0 0 0 0 0 0 3.54468554615667 0.045140524816893 277.645286351599 0 0 0.0013557845626193 0.999896254798215 0.999422105789591 0.999997373402351 NA 3) Uncertain significance New Uncertain no 0 +Levofloxacin Rv2752c p.Val67Gly Rv2752c_p.Val67Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 5843 21459 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.56487735727821 0.58431003819195 215.5 2040 False False 0 0 5.56487735727821 0 0 0.000631133876986172 0.99981363276336 0.999522895233871 0.999949218940757 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 2720 9635 0 0 0.00135528645033659 0.999585019192862 0.998937828281888 0.999886920491758 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.36894442066688 0.582297391718026 115.5 1102 False False 0 0 0 0 0 0 0 0 0 5.36894442066688 0 0 0.00135528645033659 0.999585019192862 0.998937828281888 0.999886920491758 NA 3) Uncertain significance New Uncertain no 0 +Linezolid rplC c.-13_-12insT rplC_c.-13_-12insT 1 upstream_gene_variant 800796 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 826 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid rplC c.162T>C rplC_c.162T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1772.89796229585 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1831.72385186727 NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid rplC c.165C>T rplC_c.165C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 249.394754138913 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 258.403294607065 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid rplC c.-16G>C rplC_c.-16G>C 1 upstream_gene_variant 800793 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 7 3) Uncertain significance No change no 1 +Linezolid rplC c.186C>T rplC_c.186C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1772.89796229585 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1831.72385186727 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid rplC c.195G>A rplC_c.195G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1772.89796229585 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1831.72385186727 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid rplC c.-1A>C rplC_c.-1A>C 1 upstream_gene_variant 800808 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance New Uncertain no 0 +Linezolid rplC c.201A>G rplC_c.201A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 5 152 368 17287 0.0134048257372654 0.00436645369297377 0.0310035844605445 0.991283903893572 0.989790567262371 0.992609737638175 0.0318471337579617 0.0104199915268965 0.0727531810220668 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.54524814073226 0.491702353981768 3.71897921182892 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 6 137 6618 0 0 0.0265668510962833 0.99909420289855 0.998029511465385 0.999667518193072 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 41.3735817198596 NA NA NA NA NA NA 44 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid rplC c.213C>T rplC_c.213C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 29 373 17410 0 0 0.0098410144176726 0.998337060611273 0.997612607902212 0.998886029315284 0 0 0.119444869069502 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 6.3603968556287 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 11 137 6613 0 0 0.0265668510962833 0.998339371980676 0.997030624903978 0.999170738153707 0 0 0.284914152918154 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 19.4428160901116 NA NA NA NA NA NA 13 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid rplC c.216C>T rplC_c.216C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1772.89796229585 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid rplC c.258G>A rplC_c.258G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 6 373 17433 0 0 0.0098410144176726 0.999655943574746 0.999251285574099 0.999873727224798 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 39.8653094124675 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 16 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid rplC c.273C>G rplC_c.273C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1772.89796229585 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1831.72385186727 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid rplC c.279C>T rplC_c.279C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 249.394754138913 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid rplC c.-29C>T rplC_c.-29C>T 1 upstream_gene_variant 800780 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 1 3) Uncertain significance No change no 1 +Linezolid rplC c.301T>C rplC_c.301T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1772.89796229585 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid rplC c.309G>A rplC_c.309G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1772.89796229585 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1831.72385186727 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid rplC c.315C>T rplC_c.315C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1772.89796229585 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid rplC c.-324G>A rplC_c.-324G>A 1 upstream_gene_variant 800485 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 3 3) Uncertain significance No change no 1 +Linezolid rplC c.-330_-329insGAGAAGCGT rplC_c.-330_-329insGAGAAGCGT 1 upstream_gene_variant 800479 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance No change no 1 +Linezolid rplC c.336C>T rplC_c.336C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1772.89796229585 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1831.72385186727 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid rplC c.-338G>A rplC_c.-338G>A 1 upstream_gene_variant 800471 1 1 0 1 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 1772.79911553209 1 232 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 1831.45523677849 1 16.5 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 3 3) Uncertain significance No change no 1 +Linezolid rplC c.-342G>A rplC_c.-342G>A 1 upstream_gene_variant 800467 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rplC c.-354A>G rplC_c.-354A>G 1 upstream_gene_variant 800455 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 828 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid rplC c.357G>A rplC_c.357G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1772.89796229585 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid rplC c.-359C>T rplC_c.-359C>T 1 upstream_gene_variant 800450 1 4 0 4 0 4 373 17435 0 0 0.0098410144176726 0.99977062904983 0.999412824358174 0.99993750071294 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 70.9839175273221 1 232 852 False False 0 0 70.9839175273221 0 0 0.0098410144176726 0.99977062904983 0.999412824358174 0.99993750071294 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 137 6620 0 0 0.0265668510962833 0.9993961352657 0.998454594750107 0.999835443455214 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 73.7000674034286 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 73.7000674034286 0 0 0.0265668510962833 0.9993961352657 0.998454594750107 0.999835443455214 4 3) Uncertain significance No change no 1 +Linezolid rplC c.-372G>C rplC_c.-372G>C 1 upstream_gene_variant 800437 1 2 0 2 0 3 373 17436 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 249.380449704342 1 232 852 False False 0 0 113.680929631125 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 1831.45523677849 1 16.5 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 16 3) Uncertain significance No change no 1 +Linezolid rplC c.-383C>G rplC_c.-383C>G 1 upstream_gene_variant 800426 1 3 0 3 0 3 373 17436 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 113.680929631125 1 232 852 False False 0 0 113.680929631125 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rplC c.387G>A rplC_c.387G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 0 372 17439 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 1 0.999788491924625 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.19880183801736 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid rplC c.-389G>T rplC_c.-389G>T 1 upstream_gene_variant 800420 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 836 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 509 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance No change no 1 +Linezolid rplC c.-391G>A rplC_c.-391G>A 1 upstream_gene_variant 800418 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance No change no 1 +Linezolid rplC c.-392C>A rplC_c.-392C>A 1 upstream_gene_variant 800417 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 831 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 507 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance No change no 1 +Linezolid rplC c.-396G>A rplC_c.-396G>A 1 upstream_gene_variant 800413 1 2 0 2 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 249.394754138913 1 45.5 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rplC c.-39G>C rplC_c.-39G>C 1 upstream_gene_variant 800770 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid rplC c.402T>G rplC_c.402T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1772.89796229585 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1831.72385186727 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid rplC c.-408A>G rplC_c.-408A>G 1 upstream_gene_variant 800401 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid rplC c.-420G>A rplC_c.-420G>A 1 upstream_gene_variant 800389 1 2 0 2 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 249.394754138913 1 45.5 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Linezolid rplC c.-428A>G rplC_c.-428A>G 1 upstream_gene_variant 800381 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 833 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 508 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 NA 3) Uncertain significance No change no 1 +Linezolid rplC c.42G>C rplC_c.42G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1772.89796229585 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1831.72385186727 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid rplC c.-430G>A rplC_c.-430G>A 1 upstream_gene_variant 800379 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Linezolid rplC c.-434C>G rplC_c.-434C>G 1 upstream_gene_variant 800375 1 2 0 2 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 249.394754138913 1 45.5 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rplC c.-444A>C rplC_c.-444A>C 1 upstream_gene_variant 800365 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance No change no 1 +Linezolid rplC c.-444A>G rplC_c.-444A>G 1 upstream_gene_variant 800365 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 827 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 506 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance No change no 1 +Linezolid rplC c.-452C>A rplC_c.-452C>A 1 upstream_gene_variant 800357 1 643 3 640 12 1174 361 16265 0.032171581769437 0.0167318540413245 0.0555225335979663 0.932679626125351 0.928859263277309 0.936354916254935 0.0101180438448566 0.00523876177557465 0.0176074235351033 0.0046656298600311 0.000963200467066978 0.0135739217577505 0.00254885301614273 0.000525943526756749 0.00743060009173068 0.211197195290858 0.0432389586034566 0.625075078795419 0.00107888958546039 5 852 False True 0.460532214603576 0.235041757339578 0.81771591321247 0.00824175824175824 0.00170288433968452 0.0238957625682724 0.932679626125351 0.928859263277309 0.936354916254935 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 518 1 517 3 731 134 5893 0.0218978102189781 0.00453882266370741 0.0626599862608879 0.889643719806763 0.881850430662713 0.897092084769035 0.00408719346049046 0.000843671965924252 0.0118976681616452 0.00193050193050193 4.88748827737476e-05 0.0107087239692781 0.00136612021857923 3.45865712481983e-05 0.00758780858477359 0.0850630791881982 0.0021376559886012 0.484442824606221 0.000292859865721781 3 516 False True 1 1 1 0 0 0 0 0.18048267554158 0.036691938200102 0.541288111164455 0.0074074074074074 0.000187521734003446 0.0405793591160869 0.889643719806763 0.881850430662713 0.897092084769035 3423 5) Not assoc w R UP from Uncertain to NotAwR yes 4 +Linezolid rplC c.456C>G rplC_c.456C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 9 373 17430 0 0 0.0098410144176726 0.999483915362119 0.999020537685852 0.999763986951471 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 23.7503925717735 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 9 137 6615 0 0 0.0265668510962833 0.998641304347826 0.99742234629094 0.999378535554749 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 24.7143596106325 NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid rplC c.459A>G rplC_c.459A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1772.89796229585 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1831.72385186727 NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid rplC c.-460C>G rplC_c.-460C>G 1 upstream_gene_variant 800349 1 0 0 0 0 25 373 17414 0 0 0.0098410144176726 0.998566431561442 0.997884492601935 0.999072061942677 0 0 0.137185171530712 NA NA NA 0 0 0.137185171530712 NA NA NA NA 825 852 False False 0 0 7.45702838163512 0 0 0.0098410144176726 0.998566431561442 0.997884492601935 0.999072061942677 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 29 3) Uncertain significance No change no 1 +Linezolid rplC c.-464delG rplC_c.-464delG 1 upstream_gene_variant 800344 1 3 0 3 0 3 373 17436 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 113.680929631125 1 232 852 False False 0 0 113.680929631125 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rplC c.-465C>T rplC_c.-465C>T 1 upstream_gene_variant 800344 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 835 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid rplC c.-466G>T rplC_c.-466G>T 1 upstream_gene_variant 800343 2 2 2 0 2 0 371 17439 0.00536193029490616 0.000650015532491959 0.019233955575368 1 0.999788491924625 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 8.79546869821086 Inf 0.000437371803593393 4 852 False False Inf 8.79546869821086 Inf 0.00536193029490616 0.000650015532491959 0.019233955575368 1 0.999788491924625 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid rplC c.-468G>A rplC_c.-468G>A 1 upstream_gene_variant 800341 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rplC c.-472C>T rplC_c.-472C>T 1 upstream_gene_variant 800337 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 1 3) Uncertain significance No change no 1 +Linezolid rplC c.480G>A rplC_c.480G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 249.394754138913 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 258.403294607065 NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid rplC c.-481G>A rplC_c.-481G>A 1 upstream_gene_variant 800328 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 1 3) Uncertain significance No change no 1 +Linezolid rplC c.-482G>A rplC_c.-482G>A 1 upstream_gene_variant 800327 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rplC c.-485G>C rplC_c.-485G>C 1 upstream_gene_variant 800324 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance No change no 1 +Linezolid rplC c.489C>T rplC_c.489C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1772.89796229585 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1831.72385186727 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid rplC c.48A>T rplC_c.48A>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1772.89796229585 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid rplC c.-492G>A rplC_c.-492G>A 1 upstream_gene_variant 800317 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance No change no 1 +Linezolid rplC c.-503A>G rplC_c.-503A>G 1 upstream_gene_variant 800306 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 832 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Linezolid rplC c.513C>T rplC_c.513C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1772.89796229585 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid rplC c.543G>A rplC_c.543G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1772.89796229585 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid rplC c.546G>A rplC_c.546G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 31 373 17408 0 0 0.0098410144176726 0.998222375136189 0.997477744175293 0.998791880469105 0 0 0.11218874692237 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.92425316415694 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 13 137 6611 0 0 0.0265668510962833 0.998037439613526 0.996646300229615 0.9989546183935 0 0 0.24705263800047 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 16.0112469115422 NA NA NA NA NA NA 56 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid rplC c.555C>T rplC_c.555C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 373 17434 0 0 0.0098410144176726 0.999713286312288 0.999331033812208 0.999906898501965 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.1583852845118 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid rplC c.567C>T rplC_c.567C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1772.89796229585 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid rplC c.606C>T rplC_c.606C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 249.394754138913 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 258.403294607065 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid rplC c.627C>T rplC_c.627C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1772.89796229585 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 31 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid rplC c.81C>A rplC_c.81C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 24 373 17415 0 0 0.0098410144176726 0.998623774298985 0.997952972824365 0.999118033412474 0 0 0.142473597722525 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.7909228162367 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 6 137 6618 0 0 0.0265668510962833 0.99909420289855 0.998029511465385 0.999667518193072 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 41.3735817198596 NA NA NA NA NA NA 81 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid rplC c.81C>T rplC_c.81C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 373 17435 0 0 0.0098410144176726 0.99977062904983 0.999412824358174 0.99993750071294 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.9839175273221 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid rplC c.84G>A rplC_c.84G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1772.89796229585 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1831.72385186727 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid rplC c.93C>T rplC_c.93C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1772.89796229585 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1831.72385186727 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid rplC p.Ala137Val rplC_p.Ala137Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Linezolid rplC p.Ala31Thr rplC_p.Ala31Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 22 0 22 0 24 373 17415 0 0 0.0098410144176726 0.998623774298985 0.997952972824365 0.999118033412474 0 0 0.142473597722525 0 0 0.154372512815574 0 0 0.142473597722525 0 0 8.56384662578969 1 232 852 False False 0 0 7.7909228162367 0 0 0.0098410144176726 0.998623774298985 0.997952972824365 0.999118033412474 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 137 6618 0 0 0.0265668510962833 0.99909420289855 0.998029511465385 0.999667518193072 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 41.3735817198596 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 41.3735817198596 0 0 0.0265668510962833 0.99909420289855 0.998029511465385 0.999667518193072 95 3) Uncertain significance No change no 1 +Linezolid rplC p.Ala72Thr rplC_p.Ala72Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 834 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Linezolid rplC p.Arg214Gln rplC_p.Arg214Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 829 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Linezolid rplC p.Arg38Cys rplC_p.Arg38Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 3 372 17436 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999827971787373 0.999497343686186 0.999964522241709 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 250.051722129418 1 232 852 False False 15.6236559139784 0.296818208001951 195.090770439127 0 0 0.00986733780971405 0.999827971787373 0.999497343686186 0.999964522241709 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 136 6623 0.0072992700729927 0.00018478444338478 0.0399968206735547 0.999849033816425 0.999159160462165 0.999996177874456 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 505 516 False False 0 0 0 0 0 0 0 48.6985294117647 0.615887122786072 3683.34497751641 0 0 0.0267595583791432 0.999849033816425 0.999159160462165 0.999996177874456 2 3) Uncertain significance No change no 1 +Linezolid rplC p.Arg44Leu rplC_p.Arg44Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rplC p.Arg79Leu rplC_p.Arg79Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 2 3) Uncertain significance No change no 1 +Linezolid rplC p.Asn179Lys rplC_p.Asn179Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid rplC p.Asp173Gly rplC_p.Asp173Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance No change no 1 +Linezolid rplC p.Asp18Asn rplC_p.Asp18Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 7 373 17432 0 0 0.0098410144176726 0.999598600837204 0.99917314031148 0.999838601975561 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 39.8629714341046 1 232 852 False False 0 0 32.5355852264781 0 0 0.0098410144176726 0.999598600837204 0.99917314031148 0.999838601975561 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Linezolid rplC p.Asp18del rplC_p.Asp18del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rplC p.Cys154Arg rplC_p.Cys154Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 79 64 15 102 24 271 17415 0.273458445040214 0.228838805322504 0.321715441662834 0.998623774298985 0.997952972824365 0.999118033412474 0.809523809523809 0.729974242295245 0.873980018133507 0.810126582278481 0.706241540381273 0.889652475562991 0.727272727272727 0.621895596541525 0.816804246371803 274.184501845018 151.490030910348 525.892152039802 3.28400923956026e-98 1 852 True False 273.113468634686 170.456014194565 456.666345661567 0.191044776119403 0.150349476456065 0.23730017289748 0.998623774298985 0.997952972824365 0.999118033412474 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 55 45 10 78 17 59 6607 0.56934306569343 0.482042243333949 0.653580300566734 0.997433574879227 0.99589407452958 0.998504274086152 0.821052631578947 0.729020475773064 0.892159709335871 0.818181818181818 0.690951494780656 0.90920949333646 0.725806451612903 0.597683842594978 0.831457055070029 503.923728813559 235.007374244678 1130.41444157018 1.34502764122065e-76 1 516 True False 0 0 0 0 0 0 0 513.804586241276 275.913167946794 994.3216241595 0.432692307692307 0.335851872117774 0.53346633834827 0.997433574879227 0.99589407452958 0.998504274086152 74 Assoc w R Marker of R 1) Assoc w R No change yes 1 +Linezolid rplC p.Gly120Ser rplC_p.Gly120Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 1 6 1 7 372 17432 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999598600837204 0.99917314031148 0.999838601975561 0.125 0.0031597235312519 0.526509670875206 0.142857142857142 0.00361029686190058 0.578723197043195 0.125 0.0031597235312519 0.526509670875206 7.8100358422939 0.169342099561725 64.6314078314554 0.137721351770504 15 852 False False 6.69431643625192 0.148140918599462 52.3506471819898 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999598600837204 0.99917314031148 0.999838601975561 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 136 6623 0.0072992700729927 0.00018478444338478 0.0399968206735547 0.999849033816425 0.999159160462165 0.999996177874456 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 48.6985294117647 0.615887122786072 3683.34497751641 0.0401188858130821 7.5 516 False False 0 0 0 0 0 0 0 48.6985294117647 0.615887122786072 3683.34497751641 0.0072992700729927 0.00018478444338478 0.0399968206735547 0.999849033816425 0.999159160462165 0.999996177874456 46 3) Uncertain significance No change no 1 +Linezolid rplC p.Gly12Ser rplC_p.Gly12Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rplC p.Gly131Ser rplC_p.Gly131Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 249.394754138913 1 45.5 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid rplC p.Gly136Ser rplC_p.Gly136Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid rplC p.Gly168Arg rplC_p.Gly168Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 249.394754138913 1 45.5 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Linezolid rplC p.Gly215Ser rplC_p.Gly215Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid rplC p.Gly98Arg rplC_p.Gly98Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 830 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Linezolid rplC p.His183Tyr rplC_p.His183Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 7 373 17432 0 0 0.0098410144176726 0.999598600837204 0.99917314031148 0.999838601975561 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 39.8629714341046 1 232 852 False False 0 0 32.5355852264781 0 0 0.0098410144176726 0.999598600837204 0.99917314031148 0.999838601975561 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 137 6619 0 0 0.0265668510962833 0.999245169082125 0.998239362946804 0.999754864475697 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 53.1553319379921 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 53.1553319379921 0 0 0.0265668510962833 0.999245169082125 0.998239362946804 0.999754864475697 7 3) Uncertain significance No change no 1 +Linezolid rplC p.Ile105Val rplC_p.Ile105Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rplC p.Lys61Thr rplC_p.Lys61Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 373 17436 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 249.380449704342 1 232 852 False False 0 0 113.680929631125 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 137 6621 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 258.364277567031 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 117.538380750032 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 13 3) Uncertain significance No change no 1 +Linezolid rplC p.Pro25Ser rplC_p.Pro25Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Linezolid rplC p.Pro33Leu rplC_p.Pro33Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid rplC p.Ser138Arg rplC_p.Ser138Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Linezolid rplC p.Ser89Ala rplC_p.Ser89Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 824 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid rplC p.Thr102Ser rplC_p.Thr102Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid rplC p.Thr115Ala rplC_p.Thr115Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 27 0 27 0 27 373 17412 0 0 0.0098410144176726 0.998451746086358 0.997748165293018 0.998979450700772 0 0 0.127702867615432 0 0 0.127702867615432 0 0 0.127702867615432 0 0 6.86558900005676 1 232 852 False False 0 0 6.86558900005676 0 0 0.0098410144176726 0.998451746086358 0.997748165293018 0.998979450700772 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Linezolid rplC p.Thr41Met rplC_p.Thr41Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rplC p.Thr93Ala rplC_p.Thr93Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 249.394754138913 1 45.5 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Linezolid rplC p.Tyr80Cys rplC_p.Tyr80Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 372 17438 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999942657262457 0.999680548589877 0.999998548208635 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 46.8763440860215 0.595582156681904 3550.80494241025 0.0414445055824385 12 852 False False 46.8763440860215 0.595582156681904 3550.80494241025 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Linezolid rplC p.Val185Ile rplC_p.Val185Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 18 0 18 0 21 373 17418 0 0 0.0098410144176726 0.998795802511612 0.998159842123383 0.999254433088885 0 0 0.161097615219079 0 0 0.185301968137852 0 0 0.161097615219079 0 0 10.6642963230496 1 232 852 False False 0 0 9.00985151233057 0 0 0.0098410144176726 0.998795802511612 0.998159842123383 0.999254433088885 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Linezolid rplC p.Val97Ile rplC_p.Val97Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 21 0 21 0 21 373 17418 0 0 0.0098410144176726 0.998795802511612 0.998159842123383 0.999254433088885 0 0 0.161097615219079 0 0 0.161097615219079 0 0 0.161097615219079 0 0 9.00985151233057 1 232 852 False False 0 0 9.00985151233057 0 0 0.0098410144176726 0.998795802511612 0.998159842123383 0.999254433088885 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 3 3) Uncertain significance No change no 1 +Linezolid rrl n.1004G>C rrl_n.1004G>C 1 non_coding_transcript_exon_variant 1474661 1 2 0 2 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 249.394754138913 1 45.5 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1006C>T rrl_n.1006C>T 1 non_coding_transcript_exon_variant 1474663 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 784 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 476 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 25 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1007G>T rrl_n.1007G>T 1 non_coding_transcript_exon_variant 1474664 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 484 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 249 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1009T>G rrl_n.1009T>G 1 non_coding_transcript_exon_variant 1474666 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 528 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 287 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.100T>C rrl_n.100T>C 1 non_coding_transcript_exon_variant 1473757 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.100T>G rrl_n.100T>G 1 non_coding_transcript_exon_variant 1473757 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 655 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 383 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1013C>G rrl_n.1013C>G 1 non_coding_transcript_exon_variant 1474670 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 467 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 237 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1014C>G rrl_n.1014C>G 1 non_coding_transcript_exon_variant 1474671 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 1 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1015C>T rrl_n.1015C>T 1 non_coding_transcript_exon_variant 1474672 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 785 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 477 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 19 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1016T>C rrl_n.1016T>C 1 non_coding_transcript_exon_variant 1474673 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 608 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 349 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 9 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1019T>A rrl_n.1019T>A 1 non_coding_transcript_exon_variant 1474676 1 0 0 0 0 3 373 17436 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 609 852 False False 0 0 113.680929631125 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 137 6621 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 350 516 False False 0 0 0 0 0 0 0 0 0 117.538380750032 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 20 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1019T>C rrl_n.1019T>C 1 non_coding_transcript_exon_variant 1474676 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 706 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 418 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 19 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.101G>A rrl_n.101G>A 1 non_coding_transcript_exon_variant 1473758 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 408 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 193 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 1 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1020A>G rrl_n.1020A>G 1 non_coding_transcript_exon_variant 1474677 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 755 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 456 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 18 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1022G>C rrl_n.1022G>C 1 non_coding_transcript_exon_variant 1474679 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 739 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 446 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1027T>C rrl_n.1027T>C 1 non_coding_transcript_exon_variant 1474684 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 775 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 468 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1030C>A rrl_n.1030C>A 1 non_coding_transcript_exon_variant 1474687 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 592 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 337 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1031G>C rrl_n.1031G>C 1 non_coding_transcript_exon_variant 1474688 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 468 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 238 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 3 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1033C>T rrl_n.1033C>T 1 non_coding_transcript_exon_variant 1474690 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 449 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 221 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 4 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1035G>A rrl_n.1035G>A 1 non_coding_transcript_exon_variant 1474692 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 656 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 384 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 9 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1044C>A rrl_n.1044C>A 1 non_coding_transcript_exon_variant 1474701 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance No change no 1 +Linezolid rrl n.1049G>A rrl_n.1049G>A 1 non_coding_transcript_exon_variant 1474706 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 812 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 495 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 2 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1049G>T rrl_n.1049G>T 1 non_coding_transcript_exon_variant 1474706 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1051_1052insT rrl_n.1051_1052insT 1 non_coding_transcript_exon_variant 1474708 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1052G>T rrl_n.1052G>T 1 non_coding_transcript_exon_variant 1474709 1 141 3 138 3 196 370 17243 0.00804289544235925 0.00166171954284036 0.0233236515558583 0.988760823441711 0.987083362850893 0.99027215772629 0.0150753768844221 0.00311976075921918 0.0434222568795666 0.0212765957446808 0.00440942319504993 0.0609188615396766 0.0150753768844221 0.00311976075921918 0.0434222568795666 1.01310223266745 0.205452461948534 3.0465256177399 0.771973964516633 20 852 False False 0.713306674020959 0.145191874343281 2.13205106751514 0.00804289544235925 0.00166171954284036 0.0233236515558583 0.988760823441711 0.987083362850893 0.99027215772629 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 137 6620 0 0 0.0265668510962833 0.9993961352657 0.998454594750107 0.999835443455214 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 73.7000674034286 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 73.7000674034286 0 0 0.0265668510962833 0.9993961352657 0.998454594750107 0.999835443455214 521 3) Uncertain significance No change no 1 +Linezolid rrl n.1053_1056delTGGT rrl_n.1053_1056delTGGT 1 non_coding_transcript_exon_variant 1474709 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 707 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 419 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 18 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1053T>G rrl_n.1053T>G 1 non_coding_transcript_exon_variant 1474710 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 740 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 447 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1054G>T rrl_n.1054G>T 1 non_coding_transcript_exon_variant 1474711 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 626 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 363 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 3 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1059_1060delAAinsGAG rrl_n.1059_1060delAAinsGAG 1 non_coding_transcript_exon_variant 1474716 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 450 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 222 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1060A>T rrl_n.1060A>T 1 non_coding_transcript_exon_variant 1474717 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 563 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 311 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 5 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1074G>A rrl_n.1074G>A 1 non_coding_transcript_exon_variant 1474731 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.1075A>G rrl_n.1075A>G 1 non_coding_transcript_exon_variant 1474732 1 10 0 10 0 14 373 17425 0 0 0.0098410144176726 0.999197201674408 0.998653407304194 0.999561035390213 0 0 0.231635761650116 0 0 0.30849710781876 0 0 0.231635761650116 0 0 20.9107428435628 1 232 852 False False 0 0 14.1403168132603 0 0 0.0098410144176726 0.999197201674408 0.998653407304194 0.999561035390213 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 137 6619 0 0 0.0265668510962833 0.999245169082125 0.998239362946804 0.999754864475697 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 53.1553319379921 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 53.1553319379921 0 0 0.0265668510962833 0.999245169082125 0.998239362946804 0.999754864475697 72 3) Uncertain significance No change no 1 +Linezolid rrl n.1077G>T rrl_n.1077G>T 1 non_coding_transcript_exon_variant 1474734 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 627 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 364 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 32 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1078G>T rrl_n.1078G>T 1 non_coding_transcript_exon_variant 1474735 1 2 0 2 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 249.394754138913 1 45.5 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Linezolid rrl n.1089G>C rrl_n.1089G>C 1 non_coding_transcript_exon_variant 1474746 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance No change no 1 +Linezolid rrl n.1090C>A rrl_n.1090C>A 1 non_coding_transcript_exon_variant 1474747 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 801 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 26 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1092C>T rrl_n.1092C>T 1 non_coding_transcript_exon_variant 1474749 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 423 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 203 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 18 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1093C>G rrl_n.1093C>G 1 non_coding_transcript_exon_variant 1474750 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1093C>T rrl_n.1093C>T 1 non_coding_transcript_exon_variant 1474750 1 4 0 4 0 4 373 17435 0 0 0.0098410144176726 0.99977062904983 0.999412824358174 0.99993750071294 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 70.9839175273221 1 232 852 False False 0 0 70.9839175273221 0 0 0.0098410144176726 0.99977062904983 0.999412824358174 0.99993750071294 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 25 3) Uncertain significance No change no 1 +Linezolid rrl n.1096_1097delACinsT rrl_n.1096_1097delACinsT 1 non_coding_transcript_exon_variant 1474753 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 610 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 351 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 4 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1097delC rrl_n.1097delC 1 non_coding_transcript_exon_variant 1474753 1 0 0 0 0 3 373 17436 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 546 852 False False 0 0 113.680929631125 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 302 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 45 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1103A>G rrl_n.1103A>G 1 non_coding_transcript_exon_variant 1474760 1 0 0 0 0 4 373 17435 0 0 0.0098410144176726 0.99977062904983 0.999412824358174 0.99993750071294 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 593 852 False False 0 0 70.9839175273221 0 0 0.0098410144176726 0.99977062904983 0.999412824358174 0.99993750071294 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 137 6620 0 0 0.0265668510962833 0.9993961352657 0.998454594750107 0.999835443455214 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 338 516 False False 0 0 0 0 0 0 0 0 0 73.7000674034286 0 0 0.0265668510962833 0.9993961352657 0.998454594750107 0.999835443455214 60 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1107dupG rrl_n.1107dupG 1 non_coding_transcript_exon_variant 1474761 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance No change no 1 +Linezolid rrl n.1120T>C rrl_n.1120T>C 1 non_coding_transcript_exon_variant 1474777 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 396 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 63 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1122G>A rrl_n.1122G>A 1 non_coding_transcript_exon_variant 1474779 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 469 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 53 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1123C>T rrl_n.1123C>T 1 non_coding_transcript_exon_variant 1474780 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 564 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 26 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1125G>A rrl_n.1125G>A 1 non_coding_transcript_exon_variant 1474782 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 547 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 77 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1133C>T rrl_n.1133C>T 1 non_coding_transcript_exon_variant 1474790 1 0 0 0 0 3 373 17436 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 611 852 False False 0 0 113.680929631125 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 38 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1137C>A rrl_n.1137C>A 1 non_coding_transcript_exon_variant 1474794 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 409 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 26 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1137C>T rrl_n.1137C>T 1 non_coding_transcript_exon_variant 1474794 1 0 0 0 0 7 373 17432 0 0 0.0098410144176726 0.999598600837204 0.99917314031148 0.999838601975561 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 437 852 False False 0 0 32.5355852264781 0 0 0.0098410144176726 0.999598600837204 0.99917314031148 0.999838601975561 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 7 137 6617 0 0 0.0265668510962833 0.998943236714976 0.997823883513531 0.999575024140687 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 213 516 False False 0 0 0 0 0 0 0 0 0 33.8487376789655 0 0 0.0265668510962833 0.998943236714976 0.997823883513531 0.999575024140687 78 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.113T>G rrl_n.113T>G 1 non_coding_transcript_exon_variant 1473770 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 594 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 339 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 6 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1140_1141insTATA rrl_n.1140_1141insTATA 1 non_coding_transcript_exon_variant 1474797 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 529 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 17 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1141C>T rrl_n.1141C>T 1 non_coding_transcript_exon_variant 1474798 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 786 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 15 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1144_1147delGTGC rrl_n.1144_1147delGTGC 1 non_coding_transcript_exon_variant 1474800 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 424 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 18 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1144G>A rrl_n.1144G>A 1 non_coding_transcript_exon_variant 1474801 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 708 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 420 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 5 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1145T>C rrl_n.1145T>C 1 non_coding_transcript_exon_variant 1474802 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 639 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 371 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 7 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1146G>A rrl_n.1146G>A 1 non_coding_transcript_exon_variant 1474803 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 565 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 312 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 9 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1147C>T rrl_n.1147C>T 1 non_coding_transcript_exon_variant 1474804 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 397 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1155G>A rrl_n.1155G>A 1 non_coding_transcript_exon_variant 1474812 0 0 0 0 1 2 372 17437 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999885314524915 0.999585778685812 0.999986110755134 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 566 852 False False 23.4368279569892 0.396197405925517 449.369433886118 0 0 0.00986733780971405 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 313 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 51 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1166C>G rrl_n.1166C>G 1 non_coding_transcript_exon_variant 1474823 0 0 0 0 1 8 372 17431 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999541258099661 0.999096296761143 0.99980192766755 0.111111111111111 0.00280913674659921 0.482496514917337 NA NA NA 0 0 0.369416647552819 NA NA NA NA 682 852 False False 5.85719086021505 0.131650165680732 43.8477780616287 0 0 0.00986733780971405 0.999541258099661 0.999096296761143 0.99980192766755 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 137 6619 0 0 0.0265668510962833 0.999245169082125 0.998239362946804 0.999754864475697 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 400 516 False False 0 0 0 0 0 0 0 0 0 53.1553319379921 0 0 0.0265668510962833 0.999245169082125 0.998239362946804 0.999754864475697 112 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1167A>G rrl_n.1167A>G 1 non_coding_transcript_exon_variant 1474824 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 595 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 340 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 17 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1170C>T rrl_n.1170C>T 1 non_coding_transcript_exon_variant 1474827 0 0 0 0 1 3 372 17436 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999827971787373 0.999497343686186 0.999964522241709 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 596 852 False False 15.6236559139784 0.296818208001951 195.090770439127 0 0 0.00986733780971405 0.999827971787373 0.999497343686186 0.999964522241709 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 96 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1173A>G rrl_n.1173A>G 1 non_coding_transcript_exon_variant 1474830 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 741 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 448 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 41 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1173A>T rrl_n.1173A>T 1 non_coding_transcript_exon_variant 1474830 0 0 0 0 1 1 372 17438 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999942657262457 0.999680548589877 0.999998548208635 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 548 852 False False 46.8763440860215 0.595582156681904 3550.80494241025 0 0 0.00986733780971405 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 60 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1174A>C rrl_n.1174A>C 1 non_coding_transcript_exon_variant 1474831 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 584 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 329 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 18 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1174A>T rrl_n.1174A>T 1 non_coding_transcript_exon_variant 1474831 0 0 0 0 1 2 372 17437 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999885314524915 0.999585778685812 0.999986110755134 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 530 852 False False 23.4368279569892 0.396197405925517 449.369433886118 0 0 0.00986733780971405 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 288 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 65 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1175A>T rrl_n.1175A>T 1 non_coding_transcript_exon_variant 1474832 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 657 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 385 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 17 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1182C>T rrl_n.1182C>T 1 non_coding_transcript_exon_variant 1474839 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 531 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 289 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 37 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1187G>T rrl_n.1187G>T 1 non_coding_transcript_exon_variant 1474844 0 0 0 0 1 5 372 17434 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999713286312288 0.999331033812208 0.999906898501965 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA 0 0 0.521823750104981 NA NA NA NA 723 852 False False 9.37311827956989 0.197647887799225 83.9243955038524 0 0 0.00986733780971405 0.999713286312288 0.999331033812208 0.999906898501965 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 433 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 105 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1206delA rrl_n.1206delA 1 non_coding_transcript_exon_variant 1474862 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 724 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.1207C>T rrl_n.1207C>T 1 non_coding_transcript_exon_variant 1474864 1 0 0 0 0 3 373 17436 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 410 852 False False 0 0 113.680929631125 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 137 6621 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 194 516 False False 0 0 0 0 0 0 0 0 0 117.538380750032 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 111 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1208_1212delCCTTGinsTCATTT rrl_n.1208_1212delCCTTGinsTCATTT 1 non_coding_transcript_exon_variant 1474865 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 411 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 195 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1209C>A rrl_n.1209C>A 1 non_coding_transcript_exon_variant 1474866 0 0 0 0 1 4 372 17435 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.99977062904983 0.999412824358174 0.99993750071294 0.2 0.00505076337946806 0.716417936118089 NA NA NA 0 0 0.602364635616474 NA NA NA NA 612 852 False False 11.7170698924731 0.237290978858699 118.299112140283 0 0 0.00986733780971405 0.99977062904983 0.999412824358174 0.99993750071294 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 352 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 115 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1212G>T rrl_n.1212G>T 1 non_coding_transcript_exon_variant 1474869 0 0 0 0 1 3 372 17436 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999827971787373 0.999497343686186 0.999964522241709 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 813 852 False False 15.6236559139784 0.296818208001951 195.090770439127 0 0 0.00986733780971405 0.999827971787373 0.999497343686186 0.999964522241709 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 496 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 124 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1228G>A rrl_n.1228G>A 1 non_coding_transcript_exon_variant 1474885 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance No change no 1 +Linezolid rrl n.1235G>A rrl_n.1235G>A 1 non_coding_transcript_exon_variant 1474892 1 0 0 0 0 3 373 17436 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 776 852 False False 0 0 113.680929631125 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 137 6621 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 469 516 False False 0 0 0 0 0 0 0 0 0 117.538380750032 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 63 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1239A>G rrl_n.1239A>G 1 non_coding_transcript_exon_variant 1474896 0 0 0 0 1 5 372 17434 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999713286312288 0.999331033812208 0.999906898501965 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA 0 0 0.521823750104981 NA NA NA NA 425 852 False False 9.37311827956989 0.197647887799225 83.9243955038524 0 0 0.00986733780971405 0.999713286312288 0.999331033812208 0.999906898501965 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 204 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 123 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1239A>T rrl_n.1239A>T 1 non_coding_transcript_exon_variant 1474896 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 683 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 401 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 2 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1245T>C rrl_n.1245T>C 1 non_coding_transcript_exon_variant 1474902 0 0 0 0 1 5 372 17434 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999713286312288 0.999331033812208 0.999906898501965 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA 0 0 0.521823750104981 NA NA NA NA 695 852 False False 9.37311827956989 0.197647887799225 83.9243955038524 0 0 0.00986733780971405 0.999713286312288 0.999331033812208 0.999906898501965 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 410 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 110 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1246T>A rrl_n.1246T>A 1 non_coding_transcript_exon_variant 1474903 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 412 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 196 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 26 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1246T>C rrl_n.1246T>C 1 non_coding_transcript_exon_variant 1474903 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 506 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 269 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 35 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1247G>C rrl_n.1247G>C 1 non_coding_transcript_exon_variant 1474904 0 0 0 0 1 7 372 17432 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999598600837204 0.99917314031148 0.999838601975561 0.125 0.0031597235312519 0.526509670875206 NA NA NA 0 0 0.409616397225003 NA NA NA NA 709 852 False False 6.69431643625192 0.148140918599462 52.3506471819898 0 0 0.00986733780971405 0.999598600837204 0.99917314031148 0.999838601975561 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 137 6620 0 0 0.0265668510962833 0.9993961352657 0.998454594750107 0.999835443455214 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 421 516 False False 0 0 0 0 0 0 0 0 0 73.7000674034286 0 0 0.0265668510962833 0.9993961352657 0.998454594750107 0.999835443455214 160 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1248T>C rrl_n.1248T>C 1 non_coding_transcript_exon_variant 1474905 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 485 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 250 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 35 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1253C>T rrl_n.1253C>T 1 non_coding_transcript_exon_variant 1474910 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.1256T>A rrl_n.1256T>A 1 non_coding_transcript_exon_variant 1474913 0 0 0 0 1 5 372 17434 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999713286312288 0.999331033812208 0.999906898501965 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA 0 0 0.521823750104981 NA NA NA NA 710 852 False False 9.37311827956989 0.197647887799225 83.9243955038524 0 0 0.00986733780971405 0.999713286312288 0.999331033812208 0.999906898501965 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 422 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 103 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1256T>C rrl_n.1256T>C 1 non_coding_transcript_exon_variant 1474913 1 0 0 0 0 5 373 17434 0 0 0.0098410144176726 0.999713286312288 0.999331033812208 0.999906898501965 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 470 852 False False 0 0 51.1583852845118 0 0 0.0098410144176726 0.999713286312288 0.999331033812208 0.999906898501965 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 137 6619 0 0 0.0265668510962833 0.999245169082125 0.998239362946804 0.999754864475697 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 239 516 False False 0 0 0 0 0 0 0 0 0 53.1553319379921 0 0 0.0265668510962833 0.999245169082125 0.998239362946804 0.999754864475697 48 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1262_1263insT rrl_n.1262_1263insT 1 non_coding_transcript_exon_variant 1474919 1 2 0 2 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 249.394754138913 1 45.5 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1263G>A rrl_n.1263G>A 1 non_coding_transcript_exon_variant 1474920 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 742 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 13 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1263G>C rrl_n.1263G>C 1 non_coding_transcript_exon_variant 1474920 0 0 0 0 1 3 372 17436 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999827971787373 0.999497343686186 0.999964522241709 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 532 852 False False 15.6236559139784 0.296818208001951 195.090770439127 0 0 0.00986733780971405 0.999827971787373 0.999497343686186 0.999964522241709 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 290 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 82 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1264C>A rrl_n.1264C>A 1 non_coding_transcript_exon_variant 1474921 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.1264C>T rrl_n.1264C>T 1 non_coding_transcript_exon_variant 1474921 1 19 1 18 1 19 372 17420 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.998910487986696 0.998299112600106 0.99934391915617 0.05 0.0012650894979498 0.248732762772027 0.0526315789473684 0.00133162880417942 0.260280654195214 0.05 0.0012650894979498 0.248732762772027 2.60155316606929 0.0622752380608682 16.5567224227142 0.331240793308182 17 852 False False 2.46462931522354 0.059159509481189 15.5788031780762 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.998910487986696 0.998299112600106 0.99934391915617 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 12 0 12 0 13 137 6611 0 0 0.0265668510962833 0.998037439613526 0.996646300229615 0.9989546183935 0 0 0.24705263800047 0 0 0.264648469397051 0 0 0.24705263800047 0 0 17.5618373192033 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 16.0112469115422 0 0 0.0265668510962833 0.998037439613526 0.996646300229615 0.9989546183935 21 3) Uncertain significance No change no 1 +Linezolid rrl n.1275C>T rrl_n.1275C>T 1 non_coding_transcript_exon_variant 1474932 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 451 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 223 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 32 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1276A>G rrl_n.1276A>G 1 non_coding_transcript_exon_variant 1474933 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 777 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 470 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 8 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1277C>T rrl_n.1277C>T 1 non_coding_transcript_exon_variant 1474934 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 711 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 423 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 7 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1295A>G rrl_n.1295A>G 1 non_coding_transcript_exon_variant 1474952 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 1 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1301A>G rrl_n.1301A>G 1 non_coding_transcript_exon_variant 1474958 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1326dupA rrl_n.1326dupA 1 non_coding_transcript_exon_variant 1474982 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1331C>T rrl_n.1331C>T 1 non_coding_transcript_exon_variant 1474988 1 2 1 1 1 1 372 17438 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999942657262457 0.999680548589877 0.999998548208635 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 46.8763440860215 0.595582156681904 3550.80494241025 0.0414445055824385 12 852 False False 46.8763440860215 0.595582156681904 3550.80494241025 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 1 3) Uncertain significance No change no 1 +Linezolid rrl n.1351C>A rrl_n.1351C>A 1 non_coding_transcript_exon_variant 1475008 1 7 0 7 0 7 373 17432 0 0 0.0098410144176726 0.999598600837204 0.99917314031148 0.999838601975561 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 32.5355852264781 1 232 852 False False 0 0 32.5355852264781 0 0 0.0098410144176726 0.999598600837204 0.99917314031148 0.999838601975561 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 137 6620 0 0 0.0265668510962833 0.9993961352657 0.998454594750107 0.999835443455214 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 73.7000674034286 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 73.7000674034286 0 0 0.0265668510962833 0.9993961352657 0.998454594750107 0.999835443455214 20 3) Uncertain significance No change no 1 +Linezolid rrl n.1392C>T rrl_n.1392C>T 1 non_coding_transcript_exon_variant 1475049 1 2 0 2 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 249.394754138913 1 45.5 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 258.403294607065 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 11 3) Uncertain significance No change no 1 +Linezolid rrl n.1404delC rrl_n.1404delC 1 non_coding_transcript_exon_variant 1475060 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 452 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 224 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 1 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1406A>C rrl_n.1406A>C 1 non_coding_transcript_exon_variant 1475063 1 2 0 2 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 249.394754138913 1 45.5 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.1408G>A rrl_n.1408G>A 1 non_coding_transcript_exon_variant 1475065 1 1 0 1 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 1772.79911553209 1 232 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 197 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 2 3) Uncertain significance No change no 1 +Linezolid rrl n.1410A>G rrl_n.1410A>G 1 non_coding_transcript_exon_variant 1475067 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 725 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 434 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 2 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1419C>A rrl_n.1419C>A 1 non_coding_transcript_exon_variant 1475076 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 765 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 462 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 5 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.141A>G rrl_n.141A>G 1 non_coding_transcript_exon_variant 1473798 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.1422T>C rrl_n.1422T>C 1 non_coding_transcript_exon_variant 1475079 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 453 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 225 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 2 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1424C>T rrl_n.1424C>T 1 non_coding_transcript_exon_variant 1475081 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 684 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 402 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 5 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1433A>C rrl_n.1433A>C 1 non_coding_transcript_exon_variant 1475090 1 7 0 7 0 7 373 17432 0 0 0.0098410144176726 0.999598600837204 0.99917314031148 0.999838601975561 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 32.5355852264781 1 232 852 False False 0 0 32.5355852264781 0 0 0.0098410144176726 0.999598600837204 0.99917314031148 0.999838601975561 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 6 3) Uncertain significance No change no 1 +Linezolid rrl n.1433A>T rrl_n.1433A>T 1 non_coding_transcript_exon_variant 1475090 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 685 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 403 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 6 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1438A>G rrl_n.1438A>G 1 non_coding_transcript_exon_variant 1475095 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.1440G>A rrl_n.1440G>A 1 non_coding_transcript_exon_variant 1475097 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.1442G>A rrl_n.1442G>A 1 non_coding_transcript_exon_variant 1475099 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1447T>A rrl_n.1447T>A 1 non_coding_transcript_exon_variant 1475104 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 814 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 497 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 9 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1452C>T rrl_n.1452C>T 1 non_coding_transcript_exon_variant 1475109 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 574 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 320 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 4 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1456C>T rrl_n.1456C>T 1 non_coding_transcript_exon_variant 1475113 1 1 0 1 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 1772.79911553209 1 232 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 449 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 3 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1457C>T rrl_n.1457C>T 1 non_coding_transcript_exon_variant 1475114 1 1 0 1 0 3 373 17436 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 1772.7002684543 1 232 852 False False 0 0 113.680929631125 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 404 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 29 3) Uncertain significance No change no 1 +Linezolid rrl n.1459G>A rrl_n.1459G>A 1 non_coding_transcript_exon_variant 1475116 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 426 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 205 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 10 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1465C>T rrl_n.1465C>T 1 non_coding_transcript_exon_variant 1475122 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 413 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 21 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1467A>T rrl_n.1467A>T 1 non_coding_transcript_exon_variant 1475124 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 686 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 405 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 20 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1472G>A rrl_n.1472G>A 1 non_coding_transcript_exon_variant 1475129 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 628 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 365 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 21 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1472G>T rrl_n.1472G>T 1 non_coding_transcript_exon_variant 1475129 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 658 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 386 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 46 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1480A>T rrl_n.1480A>T 1 non_coding_transcript_exon_variant 1475137 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 454 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 226 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 20 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1487G>C rrl_n.1487G>C 1 non_coding_transcript_exon_variant 1475144 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 613 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 32 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1488C>T rrl_n.1488C>T 1 non_coding_transcript_exon_variant 1475145 1 2 0 2 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 249.394754138913 1 45.5 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 258.403294607065 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 11 3) Uncertain significance No change no 1 +Linezolid rrl n.1497C>A rrl_n.1497C>A 1 non_coding_transcript_exon_variant 1475154 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 743 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 33 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.149C>T rrl_n.149C>T 1 non_coding_transcript_exon_variant 1473806 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 549 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 303 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 8 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1506T>G rrl_n.1506T>G 1 non_coding_transcript_exon_variant 1475163 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 696 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 33 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1510T>A rrl_n.1510T>A 1 non_coding_transcript_exon_variant 1475167 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 640 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1514C>T rrl_n.1514C>T 1 non_coding_transcript_exon_variant 1475171 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 697 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 411 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 30 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1518G>A rrl_n.1518G>A 1 non_coding_transcript_exon_variant 1475175 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 766 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 44 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1518G>C rrl_n.1518G>C 1 non_coding_transcript_exon_variant 1475175 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 698 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 412 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 17 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1525T>A rrl_n.1525T>A 1 non_coding_transcript_exon_variant 1475182 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 726 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1531C>G rrl_n.1531C>G 1 non_coding_transcript_exon_variant 1475188 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 398 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 186 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 5 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1531C>T rrl_n.1531C>T 1 non_coding_transcript_exon_variant 1475188 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 787 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 26 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1563G>A rrl_n.1563G>A 1 non_coding_transcript_exon_variant 1475220 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 496 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1564C>T rrl_n.1564C>T 1 non_coding_transcript_exon_variant 1475221 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.1565G>A rrl_n.1565G>A 1 non_coding_transcript_exon_variant 1475222 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance No change no 1 +Linezolid rrl n.1572dupA rrl_n.1572dupA 1 non_coding_transcript_exon_variant 1475227 1 9 0 9 0 10 373 17429 0 0 0.0098410144176726 0.999426572624577 0.998945700319482 0.999724986127498 0 0 0.30849710781876 0 0 0.336267116879942 0 0 0.30849710781876 0 0 23.7495174897399 1 232 852 False False 0 0 20.9154638474844 0 0 0.0098410144176726 0.999426572624577 0.998945700319482 0.999724986127498 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.1573C>T rrl_n.1573C>T 1 non_coding_transcript_exon_variant 1475230 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.157A>C rrl_n.157A>C 1 non_coding_transcript_exon_variant 1473814 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.157A>G rrl_n.157A>G 1 non_coding_transcript_exon_variant 1473814 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 788 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 478 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 2 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1584C>G rrl_n.1584C>G 1 non_coding_transcript_exon_variant 1475241 1 3 0 3 0 3 373 17436 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 113.680929631125 1 232 852 False False 0 0 113.680929631125 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 137 6621 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 117.538380750032 1 16.5 516 False False 0 0 0 0 0 0 0 0 0 117.538380750032 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 34 3) Uncertain significance No change no 1 +Linezolid rrl n.158T>C rrl_n.158T>C 1 non_coding_transcript_exon_variant 1473815 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 438 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 214 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1592T>C rrl_n.1592T>C 1 non_coding_transcript_exon_variant 1475249 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 518 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 279 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance No change no 1 +Linezolid rrl n.1598C>T rrl_n.1598C>T 1 non_coding_transcript_exon_variant 1475255 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance No change no 1 +Linezolid rrl n.1599C>T rrl_n.1599C>T 1 non_coding_transcript_exon_variant 1475256 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Linezolid rrl n.1602T>G rrl_n.1602T>G 1 non_coding_transcript_exon_variant 1475259 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 6 3) Uncertain significance No change no 1 +Linezolid rrl n.1608delG rrl_n.1608delG 1 non_coding_transcript_exon_variant 1475260 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 668 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 392 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance No change no 1 +Linezolid rrl n.1609T>C rrl_n.1609T>C 1 non_coding_transcript_exon_variant 1475266 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 699 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 413 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 3 3) Uncertain significance No change no 1 +Linezolid rrl n.160T>C rrl_n.160T>C 1 non_coding_transcript_exon_variant 1473817 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 2 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1613G>C rrl_n.1613G>C 1 non_coding_transcript_exon_variant 1475270 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Linezolid rrl n.1624dupC rrl_n.1624dupC 1 non_coding_transcript_exon_variant 1475280 1 2 0 2 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 249.394754138913 1 45.5 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1627C>G rrl_n.1627C>G 1 non_coding_transcript_exon_variant 1475284 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Linezolid rrl n.1628G>A rrl_n.1628G>A 1 non_coding_transcript_exon_variant 1475285 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 486 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 251 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1634A>C rrl_n.1634A>C 1 non_coding_transcript_exon_variant 1475291 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 802 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 487 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 3 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1648A>C rrl_n.1648A>C 1 non_coding_transcript_exon_variant 1475305 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1650T>G rrl_n.1650T>G 1 non_coding_transcript_exon_variant 1475307 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 487 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 252 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1658A>G rrl_n.1658A>G 1 non_coding_transcript_exon_variant 1475315 1 2 0 2 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 249.394754138913 1 45.5 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 1 3) Uncertain significance No change no 1 +Linezolid rrl n.1658A>T rrl_n.1658A>T 1 non_coding_transcript_exon_variant 1475315 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 789 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 479 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 10 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.165A>G rrl_n.165A>G 1 non_coding_transcript_exon_variant 1473822 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 519 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 280 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 1 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1660G>A rrl_n.1660G>A 1 non_coding_transcript_exon_variant 1475317 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.168_169dupTA rrl_n.168_169dupTA 1 non_coding_transcript_exon_variant 1473819 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance No change no 1 +Linezolid rrl n.1680C>T rrl_n.1680C>T 1 non_coding_transcript_exon_variant 1475337 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 614 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 353 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 1 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1681G>A rrl_n.1681G>A 1 non_coding_transcript_exon_variant 1475338 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 1 3) Uncertain significance No change no 1 +Linezolid rrl n.1682T>G rrl_n.1682T>G 1 non_coding_transcript_exon_variant 1475339 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 615 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 354 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1683A>G rrl_n.1683A>G 1 non_coding_transcript_exon_variant 1475340 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 533 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 291 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1685C>G rrl_n.1685C>G 1 non_coding_transcript_exon_variant 1475342 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance No change no 1 +Linezolid rrl n.1697A>T rrl_n.1697A>T 1 non_coding_transcript_exon_variant 1475354 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1698C>T rrl_n.1698C>T 1 non_coding_transcript_exon_variant 1475355 1 0 0 0 0 4 373 17435 0 0 0.0098410144176726 0.99977062904983 0.999412824358174 0.99993750071294 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 427 852 False False 0 0 70.9839175273221 0 0 0.0098410144176726 0.99977062904983 0.999412824358174 0.99993750071294 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 137 6621 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 206 516 False False 0 0 0 0 0 0 0 0 0 117.538380750032 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 15 3) Uncertain significance No change no 1 +Linezolid rrl n.1719A>C rrl_n.1719A>C 1 non_coding_transcript_exon_variant 1475376 1 3 0 3 0 3 373 17436 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 113.680929631125 1 232 852 False False 0 0 113.680929631125 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.1722G>T rrl_n.1722G>T 1 non_coding_transcript_exon_variant 1475379 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.1723C>T rrl_n.1723C>T 1 non_coding_transcript_exon_variant 1475380 1 2 0 2 0 3 373 17436 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 249.380449704342 1 232 852 False False 0 0 113.680929631125 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 258.403294607065 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 2 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.173_176delTGCGinsCGTGT rrl_n.173_176delTGCGinsCGTGT 1 non_coding_transcript_exon_variant 1473830 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 399 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 187 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1738T>C rrl_n.1738T>C 1 non_coding_transcript_exon_variant 1475395 1 2 0 2 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 249.394754138913 1 45.5 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1743C>T rrl_n.1743C>T 1 non_coding_transcript_exon_variant 1475400 1 2 0 2 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 249.394754138913 1 45.5 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.174G>A rrl_n.174G>A 1 non_coding_transcript_exon_variant 1473831 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance No change no 1 +Linezolid rrl n.176_177insT rrl_n.176_177insT 1 non_coding_transcript_exon_variant 1473833 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 756 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 457 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 10 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1760G>A rrl_n.1760G>A 1 non_coding_transcript_exon_variant 1475417 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance No change no 1 +Linezolid rrl n.1772G>A rrl_n.1772G>A 1 non_coding_transcript_exon_variant 1475429 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 778 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 471 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 4 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1778G>A rrl_n.1778G>A 1 non_coding_transcript_exon_variant 1475435 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1785C>G rrl_n.1785C>G 1 non_coding_transcript_exon_variant 1475442 1 2 0 2 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 249.394754138913 1 45.5 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1786G>A rrl_n.1786G>A 1 non_coding_transcript_exon_variant 1475443 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 597 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 341 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 1 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1788T>A rrl_n.1788T>A 1 non_coding_transcript_exon_variant 1475445 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance No change no 1 +Linezolid rrl n.1794T>C rrl_n.1794T>C 1 non_coding_transcript_exon_variant 1475451 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Linezolid rrl n.1795C>A rrl_n.1795C>A 1 non_coding_transcript_exon_variant 1475452 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 659 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 387 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 5 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1795C>T rrl_n.1795C>T 1 non_coding_transcript_exon_variant 1475452 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance No change no 1 +Linezolid rrl n.179A>G rrl_n.179A>G 1 non_coding_transcript_exon_variant 1473836 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Linezolid rrl n.17dupG rrl_n.17dupG 1 non_coding_transcript_exon_variant 1473671 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1803A>G rrl_n.1803A>G 1 non_coding_transcript_exon_variant 1475460 1 2 0 2 0 3 373 17436 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 249.380449704342 1 232 852 False False 0 0 113.680929631125 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 137 6621 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 258.364277567031 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 117.538380750032 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 3 3) Uncertain significance No change no 1 +Linezolid rrl n.1811C>T rrl_n.1811C>T 1 non_coding_transcript_exon_variant 1475468 1 2 0 2 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 249.394754138913 1 45.5 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 258.403294607065 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 3 3) Uncertain significance No change no 1 +Linezolid rrl n.1819G>A rrl_n.1819G>A 1 non_coding_transcript_exon_variant 1475476 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.1821dupG rrl_n.1821dupG 1 non_coding_transcript_exon_variant 1475477 1 2 0 2 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 249.394754138913 1 45.5 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 258.403294607065 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 NA 3) Uncertain significance No change no 1 +Linezolid rrl n.1822C>T rrl_n.1822C>T 1 non_coding_transcript_exon_variant 1475479 1 24 0 24 3 26 370 17413 0.00804289544235925 0.00166171954284036 0.0233236515558583 0.9985090888239 0.997816227397373 0.999025863367059 0.103448275862068 0.0218637368298536 0.273515197892423 0 0 0.142473597722525 0 0 0.132274604497754 0 0 7.85341593890256 1 45.5 852 False False 5.43024948024948 1.04712781375116 17.8309173682913 0 0 0.00992040933174687 0.9985090888239 0.997816227397373 0.999025863367059 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 21 0 21 3 23 134 6601 0.0218978102189781 0.00453882266370741 0.0626599862608879 0.996527777777777 0.994794489948338 0.997797674590488 0.115384615384615 0.0244580753179622 0.301540400107567 0 0 0.161097615219079 0 0 0.148185128915224 0 0 9.58094254160135 1 104.5 516 False False 0 0 0 0 0 0 0 6.42537313432835 1.21952228723407 21.6414136304783 0 0 0.0271534828798001 0.996527777777777 0.994794489948338 0.997797674590488 9 3) Uncertain significance No change no 1 +Linezolid rrl n.1823A>T rrl_n.1823A>T 1 non_coding_transcript_exon_variant 1475480 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 575 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 321 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 1 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1824C>G rrl_n.1824C>G 1 non_coding_transcript_exon_variant 1475481 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 790 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 480 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1825A>G rrl_n.1825A>G 1 non_coding_transcript_exon_variant 1475482 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 598 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 342 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 1 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1826C>T rrl_n.1826C>T 1 non_coding_transcript_exon_variant 1475483 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 744 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 450 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 4 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1842C>T rrl_n.1842C>T 1 non_coding_transcript_exon_variant 1475499 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 641 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 372 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 12 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1847C>A rrl_n.1847C>A 1 non_coding_transcript_exon_variant 1475504 1 14 0 14 0 14 373 17425 0 0 0.0098410144176726 0.999197201674408 0.998653407304194 0.999561035390213 0 0 0.231635761650116 0 0 0.231635761650116 0 0 0.231635761650116 0 0 14.1403168132603 1 232 852 False False 0 0 14.1403168132603 0 0 0.0098410144176726 0.999197201674408 0.998653407304194 0.999561035390213 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 258.403294607065 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 17 3) Uncertain significance No change no 1 +Linezolid rrl n.1851A>G rrl_n.1851A>G 1 non_coding_transcript_exon_variant 1475508 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 616 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.1851A>T rrl_n.1851A>T 1 non_coding_transcript_exon_variant 1475508 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 550 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 304 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 14 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1859T>C rrl_n.1859T>C 1 non_coding_transcript_exon_variant 1475516 1 1 0 1 2 1 371 17438 0.00536193029490616 0.000650015532491959 0.019233955575368 0.999942657262457 0.999680548589877 0.999998548208635 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 1782.18922155694 1 232 852 False False 94.0053908355795 4.87516991021522 5292.01172125943 0 0 0.00989380240135706 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance No change no 1 +Linezolid rrl n.1861A>G rrl_n.1861A>G 1 non_coding_transcript_exon_variant 1475518 1 11 0 11 0 11 373 17428 0 0 0.0098410144176726 0.999369229887034 0.998871658968789 0.999685081116298 0 0 0.284914152918154 0 0 0.284914152918154 0 0 0.284914152918154 0 0 18.6911206624175 1 232 852 False False 0 0 18.6911206624175 0 0 0.0098410144176726 0.999369229887034 0.998871658968789 0.999685081116298 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 0 9 137 6615 0 0 0.0265668510962833 0.998641304347826 0.99742234629094 0.999378535554749 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.336267116879942 0 0 24.7143596106325 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 24.7143596106325 0 0 0.0265668510962833 0.998641304347826 0.99742234629094 0.999378535554749 13 3) Uncertain significance No change no 1 +Linezolid rrl n.1865A>C rrl_n.1865A>C 1 non_coding_transcript_exon_variant 1475522 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 617 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 355 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1869C>A rrl_n.1869C>A 1 non_coding_transcript_exon_variant 1475526 1 0 0 0 0 3 373 17436 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 727 852 False False 0 0 113.680929631125 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 137 6621 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 435 516 False False 0 0 0 0 0 0 0 0 0 117.538380750032 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 46 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1874C>T rrl_n.1874C>T 1 non_coding_transcript_exon_variant 1475531 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 728 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 436 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 21 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1875A>G rrl_n.1875A>G 1 non_coding_transcript_exon_variant 1475532 1 3 0 3 0 5 373 17434 0 0 0.0098410144176726 0.999713286312288 0.999331033812208 0.999906898501965 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 113.667723477788 1 232 852 False False 0 0 51.1583852845118 0 0 0.0098410144176726 0.999713286312288 0.999331033812208 0.999906898501965 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 253 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 5 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.187C>T rrl_n.187C>T 1 non_coding_transcript_exon_variant 1473844 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 497 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 262 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 15 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1881T>A rrl_n.1881T>A 1 non_coding_transcript_exon_variant 1475538 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 488 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 254 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 25 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1882A>G rrl_n.1882A>G 1 non_coding_transcript_exon_variant 1475539 1 0 0 0 0 8 373 17431 0 0 0.0098410144176726 0.999541258099661 0.999096296761143 0.99980192766755 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 439 852 False False 0 0 27.4795886207099 0 0 0.0098410144176726 0.999541258099661 0.999096296761143 0.99980192766755 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 8 137 6616 0 0 0.0265668510962833 0.998792270531401 0.997621685806941 0.999478448499522 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 215 516 False False 0 0 0 0 0 0 0 0 0 28.574210735743 0 0 0.0265668510962833 0.998792270531401 0.997621685806941 0.999478448499522 35 3) Uncertain significance No change no 1 +Linezolid rrl n.1882A>T rrl_n.1882A>T 1 non_coding_transcript_exon_variant 1475539 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 745 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 451 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 34 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1885A>G rrl_n.1885A>G 1 non_coding_transcript_exon_variant 1475542 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 803 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 488 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 7 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1887A>T rrl_n.1887A>T 1 non_coding_transcript_exon_variant 1475544 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 746 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 452 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 15 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1888T>G rrl_n.1888T>G 1 non_coding_transcript_exon_variant 1475545 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 414 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 198 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 37 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1890A>G rrl_n.1890A>G 1 non_coding_transcript_exon_variant 1475547 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1890dupA rrl_n.1890dupA 1 non_coding_transcript_exon_variant 1475545 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1893A>G rrl_n.1893A>G 1 non_coding_transcript_exon_variant 1475550 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 618 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 356 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 12 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.-18C>T rrl_n.-18C>T 1 upstream_gene_variant 1473640 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance No change no 1 +Linezolid rrl n.1914A>T rrl_n.1914A>T 1 non_coding_transcript_exon_variant 1475571 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 489 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 255 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 2 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1917C>A rrl_n.1917C>A 1 non_coding_transcript_exon_variant 1475574 0 0 0 0 1 5 372 17434 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999713286312288 0.999331033812208 0.999906898501965 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA 0 0 0.521823750104981 NA NA NA NA 551 852 False False 9.37311827956989 0.197647887799225 83.9243955038524 0 0 0.00986733780971405 0.999713286312288 0.999331033812208 0.999906898501965 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 137 6621 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 305 516 False False 0 0 0 0 0 0 0 0 0 117.538380750032 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 156 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1918C>G rrl_n.1918C>G 1 non_coding_transcript_exon_variant 1475575 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1919C>T rrl_n.1919C>T 1 non_coding_transcript_exon_variant 1475576 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 5 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1921C>T rrl_n.1921C>T 1 non_coding_transcript_exon_variant 1475578 1 2 0 2 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 249.394754138913 1 45.5 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 258.403294607065 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 1 3) Uncertain significance No change no 1 +Linezolid rrl n.1924A>G rrl_n.1924A>G 1 non_coding_transcript_exon_variant 1475581 1 2 0 2 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 249.394754138913 1 45.5 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 12 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1932G>A rrl_n.1932G>A 1 non_coding_transcript_exon_variant 1475589 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1940G>A rrl_n.1940G>A 1 non_coding_transcript_exon_variant 1475597 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Linezolid rrl n.1941G>A rrl_n.1941G>A 1 non_coding_transcript_exon_variant 1475598 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance No change no 1 +Linezolid rrl n.1942A>G rrl_n.1942A>G 1 non_coding_transcript_exon_variant 1475599 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1948_1950dupATA rrl_n.1948_1950dupATA 1 non_coding_transcript_exon_variant 1475603 1 1 1 0 1 0 372 17439 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 1 0.999788491924625 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 1.19880183801736 Inf 0.0209409386930159 8.5 852 False False Inf 1.19880183801736 Inf 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 1 0.999788491924625 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1948A>G rrl_n.1948A>G 1 non_coding_transcript_exon_variant 1475605 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 700 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.194G>C rrl_n.194G>C 1 non_coding_transcript_exon_variant 1473851 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 534 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 10 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1960C>T rrl_n.1960C>T 1 non_coding_transcript_exon_variant 1475617 1 5 0 5 0 6 373 17433 0 0 0.0098410144176726 0.999655943574746 0.999251285574099 0.999873727224798 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 51.1554450286559 1 45.5 852 False False 0 0 39.8653094124675 0 0 0.0098410144176726 0.999655943574746 0.999251285574099 0.999873727224798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 137 6620 0 0 0.0265668510962833 0.9993961352657 0.998454594750107 0.999835443455214 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 117.520679860744 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 73.7000674034286 0 0 0.0265668510962833 0.9993961352657 0.998454594750107 0.999835443455214 13 3) Uncertain significance No change no 1 +Linezolid rrl n.1968delG rrl_n.1968delG 1 non_coding_transcript_exon_variant 1475623 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 642 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 373 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 1 3) Uncertain significance No change no 1 +Linezolid rrl n.1979A>G rrl_n.1979A>G 1 non_coding_transcript_exon_variant 1475636 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance No change no 1 +Linezolid rrl n.1992A>G rrl_n.1992A>G 1 non_coding_transcript_exon_variant 1475649 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 440 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 216 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 11 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1998T>A rrl_n.1998T>A 1 non_coding_transcript_exon_variant 1475655 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 455 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 227 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 1 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.1998T>C rrl_n.1998T>C 1 non_coding_transcript_exon_variant 1475655 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 585 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 330 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 3 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.19G>A rrl_n.19G>A 1 non_coding_transcript_exon_variant 1473676 1 2 0 2 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 249.394754138913 1 45.5 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Linezolid rrl n.2002G>A rrl_n.2002G>A 1 non_coding_transcript_exon_variant 1475659 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 669 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 393 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 14 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2010G>A rrl_n.2010G>A 1 non_coding_transcript_exon_variant 1475667 1 0 0 0 0 4 373 17435 0 0 0.0098410144176726 0.99977062904983 0.999412824358174 0.99993750071294 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 471 852 False False 0 0 70.9839175273221 0 0 0.0098410144176726 0.99977062904983 0.999412824358174 0.99993750071294 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.2015C>G rrl_n.2015C>G 1 non_coding_transcript_exon_variant 1475672 0 0 0 0 1 1 372 17438 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999942657262457 0.999680548589877 0.999998548208635 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 767 852 False False 46.8763440860215 0.595582156681904 3550.80494241025 0 0 0.00986733780971405 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 33 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2015C>T rrl_n.2015C>T 1 non_coding_transcript_exon_variant 1475672 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 507 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 270 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 22 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2016T>C rrl_n.2016T>C 1 non_coding_transcript_exon_variant 1475673 0 0 0 0 1 2 372 17437 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999885314524915 0.999585778685812 0.999986110755134 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 490 852 False False 23.4368279569892 0.396197405925517 449.369433886118 0 0 0.00986733780971405 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 256 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 57 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2022C>T rrl_n.2022C>T 1 non_coding_transcript_exon_variant 1475679 1 0 0 0 0 4 373 17435 0 0 0.0098410144176726 0.99977062904983 0.999412824358174 0.99993750071294 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 508 852 False False 0 0 70.9839175273221 0 0 0.0098410144176726 0.99977062904983 0.999412824358174 0.99993750071294 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.2023A>G rrl_n.2023A>G 1 non_coding_transcript_exon_variant 1475680 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 1 3) Uncertain significance No change no 1 +Linezolid rrl n.2024C>T rrl_n.2024C>T 1 non_coding_transcript_exon_variant 1475681 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2029C>T rrl_n.2029C>T 1 non_coding_transcript_exon_variant 1475686 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Linezolid rrl n.2030C>A rrl_n.2030C>A 1 non_coding_transcript_exon_variant 1475687 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 2 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2030C>T rrl_n.2030C>T 1 non_coding_transcript_exon_variant 1475687 1 2 0 2 1 3 372 17436 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999827971787373 0.999497343686186 0.999964522241709 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 250.051722129418 1 232 852 False False 15.6236559139784 0.296818208001951 195.090770439127 0 0 0.00986733780971405 0.999827971787373 0.999497343686186 0.999964522241709 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 47 3) Uncertain significance No change no 1 +Linezolid rrl n.2031G>C rrl_n.2031G>C 1 non_coding_transcript_exon_variant 1475688 0 0 0 0 1 1 372 17438 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999942657262457 0.999680548589877 0.999998548208635 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 768 852 False False 46.8763440860215 0.595582156681904 3550.80494241025 0 0 0.00986733780971405 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 29 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2039T>C rrl_n.2039T>C 1 non_coding_transcript_exon_variant 1475696 0 0 0 0 1 2 372 17437 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999885314524915 0.999585778685812 0.999986110755134 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 509 852 False False 23.4368279569892 0.396197405925517 449.369433886118 0 0 0.00986733780971405 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 271 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 50 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2040C>T rrl_n.2040C>T 1 non_coding_transcript_exon_variant 1475697 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 3 3) Uncertain significance No change no 1 +Linezolid rrl n.2042C>T rrl_n.2042C>T 1 non_coding_transcript_exon_variant 1475699 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 567 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 314 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 60 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2046A>G rrl_n.2046A>G 1 non_coding_transcript_exon_variant 1475703 0 0 0 0 1 2 372 17437 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999885314524915 0.999585778685812 0.999986110755134 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 643 852 False False 23.4368279569892 0.396197405925517 449.369433886118 0 0 0.00986733780971405 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 374 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 51 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2050T>A rrl_n.2050T>A 1 non_coding_transcript_exon_variant 1475707 0 0 0 0 1 1 372 17438 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999942657262457 0.999680548589877 0.999998548208635 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 552 852 False False 46.8763440860215 0.595582156681904 3550.80494241025 0 0 0.00986733780971405 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 41 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2056C>G rrl_n.2056C>G 1 non_coding_transcript_exon_variant 1475713 0 0 0 0 1 3 372 17436 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999827971787373 0.999497343686186 0.999964522241709 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 498 852 False False 15.6236559139784 0.296818208001951 195.090770439127 0 0 0.00986733780971405 0.999827971787373 0.999497343686186 0.999964522241709 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 263 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 77 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2059A>G rrl_n.2059A>G 1 non_coding_transcript_exon_variant 1475716 0 0 0 0 1 3 372 17436 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999827971787373 0.999497343686186 0.999964522241709 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 769 852 False False 15.6236559139784 0.296818208001951 195.090770439127 0 0 0.00986733780971405 0.999827971787373 0.999497343686186 0.999964522241709 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 463 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 88 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.205C>A rrl_n.205C>A 1 non_coding_transcript_exon_variant 1473862 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 441 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 27 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2061T>C rrl_n.2061T>C 1 non_coding_transcript_exon_variant 1475718 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.2064C>T rrl_n.2064C>T 1 non_coding_transcript_exon_variant 1475721 1 1 0 1 0 13 373 17426 0 0 0.0098410144176726 0.99925454441195 0.998725585600835 0.999603018488228 0 0 0.24705263800047 0 0 0.975 0 0 0.24705263800047 0 0 1771.71178040417 1 232 852 False False 0 0 15.3910294344092 0 0 0.0098410144176726 0.99925454441195 0.998725585600835 0.999603018488228 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.2078T>C rrl_n.2078T>C 1 non_coding_transcript_exon_variant 1475735 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 629 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 366 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 1 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2083G>C rrl_n.2083G>C 1 non_coding_transcript_exon_variant 1475740 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 619 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 357 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 8 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2090A>G rrl_n.2090A>G 1 non_coding_transcript_exon_variant 1475747 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 568 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 315 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 11 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2093A>C rrl_n.2093A>C 1 non_coding_transcript_exon_variant 1475750 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 729 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 437 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 7 3) Uncertain significance No change no 1 +Linezolid rrl n.2095C>T rrl_n.2095C>T 1 non_coding_transcript_exon_variant 1475752 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 5 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2096dupC rrl_n.2096dupC 1 non_coding_transcript_exon_variant 1475750 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2107A>G rrl_n.2107A>G 1 non_coding_transcript_exon_variant 1475764 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 644 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.210C>G rrl_n.210C>G 1 non_coding_transcript_exon_variant 1473867 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 815 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 498 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 21 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2110G>T rrl_n.2110G>T 1 non_coding_transcript_exon_variant 1475767 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2112dupT rrl_n.2112dupT 1 non_coding_transcript_exon_variant 1475768 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.2115A>T rrl_n.2115A>T 1 non_coding_transcript_exon_variant 1475772 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance No change no 1 +Linezolid rrl n.2118G>T rrl_n.2118G>T 1 non_coding_transcript_exon_variant 1475775 1 0 0 0 0 3 373 17436 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 472 852 False False 0 0 113.680929631125 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 137 6621 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 240 516 False False 0 0 0 0 0 0 0 0 0 117.538380750032 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 41 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.211C>T rrl_n.211C>T 1 non_coding_transcript_exon_variant 1473868 1 17 0 17 0 17 373 17422 0 0 0.0098410144176726 0.999025173461781 0.998439665579061 0.999432028313824 0 0 0.195064322969093 0 0 0.195064322969093 0 0 0.195064322969093 0 0 11.3647229722871 1 232 852 False False 0 0 11.3647229722871 0 0 0.0098410144176726 0.999025173461781 0.998439665579061 0.999432028313824 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.2120A>G rrl_n.2120A>G 1 non_coding_transcript_exon_variant 1475777 1 2 0 2 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 249.394754138913 1 45.5 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Linezolid rrl n.2123A>G rrl_n.2123A>G 1 non_coding_transcript_exon_variant 1475780 1 5 0 5 0 5 373 17434 0 0 0.0098410144176726 0.999713286312288 0.999331033812208 0.999906898501965 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 51.1583852845118 1 45.5 852 False False 0 0 51.1583852845118 0 0 0.0098410144176726 0.999713286312288 0.999331033812208 0.999906898501965 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 2 3) Uncertain significance No change no 1 +Linezolid rrl n.2126T>G rrl_n.2126T>G 1 non_coding_transcript_exon_variant 1475783 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 400 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 188 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 70 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.212C>T rrl_n.212C>T 1 non_coding_transcript_exon_variant 1473869 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 1 3) Uncertain significance No change no 1 +Linezolid rrl n.2132C>G rrl_n.2132C>G 1 non_coding_transcript_exon_variant 1475789 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.2134A>G rrl_n.2134A>G 1 non_coding_transcript_exon_variant 1475791 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 535 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 292 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 5 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.213G>A rrl_n.213G>A 1 non_coding_transcript_exon_variant 1473870 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 510 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 272 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 12 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2146T>C rrl_n.2146T>C 1 non_coding_transcript_exon_variant 1475803 0 0 0 0 1 4 372 17435 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.99977062904983 0.999412824358174 0.99993750071294 0.2 0.00505076337946806 0.716417936118089 NA NA NA 0 0 0.602364635616474 NA NA NA NA 473 852 False False 11.7170698924731 0.237290978858699 118.299112140283 0 0 0.00986733780971405 0.99977062904983 0.999412824358174 0.99993750071294 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 137 6621 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 241 516 False False 0 0 0 0 0 0 0 0 0 117.538380750032 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 158 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2147G>C rrl_n.2147G>C 1 non_coding_transcript_exon_variant 1475804 0 0 0 0 1 4 372 17435 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.99977062904983 0.999412824358174 0.99993750071294 0.2 0.00505076337946806 0.716417936118089 NA NA NA 0 0 0.602364635616474 NA NA NA NA 660 852 False False 11.7170698924731 0.237290978858699 118.299112140283 0 0 0.00986733780971405 0.99977062904983 0.999412824358174 0.99993750071294 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 137 6621 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 388 516 False False 0 0 0 0 0 0 0 0 0 117.538380750032 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 158 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.214T>C rrl_n.214T>C 1 non_coding_transcript_exon_variant 1473871 1 0 0 0 0 3 373 17436 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 791 852 False False 0 0 113.680929631125 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 137 6621 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 481 516 False False 0 0 0 0 0 0 0 0 0 117.538380750032 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 27 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.214T>G rrl_n.214T>G 1 non_coding_transcript_exon_variant 1473871 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 701 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 414 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 27 3) Uncertain significance No change no 1 +Linezolid rrl n.2152C>T rrl_n.2152C>T 1 non_coding_transcript_exon_variant 1475809 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance No change no 1 +Linezolid rrl n.2152dupC rrl_n.2152dupC 1 non_coding_transcript_exon_variant 1475808 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2159C>G rrl_n.2159C>G 1 non_coding_transcript_exon_variant 1475816 0 0 0 0 1 4 372 17435 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.99977062904983 0.999412824358174 0.99993750071294 0.2 0.00505076337946806 0.716417936118089 NA NA NA 0 0 0.602364635616474 NA NA NA NA 511 852 False False 11.7170698924731 0.237290978858699 118.299112140283 0 0 0.00986733780971405 0.99977062904983 0.999412824358174 0.99993750071294 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 137 6621 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 273 516 False False 0 0 0 0 0 0 0 0 0 117.538380750032 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 192 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2160A>G rrl_n.2160A>G 1 non_coding_transcript_exon_variant 1475817 0 0 0 0 1 4 372 17435 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.99977062904983 0.999412824358174 0.99993750071294 0.2 0.00505076337946806 0.716417936118089 NA NA NA 0 0 0.602364635616474 NA NA NA NA 687 852 False False 11.7170698924731 0.237290978858699 118.299112140283 0 0 0.00986733780971405 0.99977062904983 0.999412824358174 0.99993750071294 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 137 6621 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 406 516 False False 0 0 0 0 0 0 0 0 0 117.538380750032 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 192 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2180C>T rrl_n.2180C>T 1 non_coding_transcript_exon_variant 1475837 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2186G>A rrl_n.2186G>A 1 non_coding_transcript_exon_variant 1475843 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 661 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 13 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2192G>A rrl_n.2192G>A 1 non_coding_transcript_exon_variant 1475849 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 474 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 10 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2196C>T rrl_n.2196C>T 1 non_coding_transcript_exon_variant 1475853 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 520 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 12 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.219G>A rrl_n.219G>A 1 non_coding_transcript_exon_variant 1473876 1 0 0 0 0 6 373 17433 0 0 0.0098410144176726 0.999655943574746 0.999251285574099 0.999873727224798 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 456 852 False False 0 0 39.8653094124675 0 0 0.0098410144176726 0.999655943574746 0.999251285574099 0.999873727224798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 137 6619 0 0 0.0265668510962833 0.999245169082125 0.998239362946804 0.999754864475697 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 228 516 False False 0 0 0 0 0 0 0 0 0 53.1553319379921 0 0 0.0265668510962833 0.999245169082125 0.998239362946804 0.999754864475697 64 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.-21A>G rrl_n.-21A>G 1 upstream_gene_variant 1473637 1 15 0 15 1 16 372 17423 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999082516199323 0.998510490256918 0.999475490673985 0.0588235294117647 0.00148817439126663 0.28688939666722 0 0 0.218019360910534 0 0 0.205907214207822 0 0 13.1111013333376 1 45.5 852 False False 2.92725134408602 0.0696191680488212 18.9341421371148 0 0 0.00986733780971405 0.999082516199323 0.998510490256918 0.999475490673985 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 136 6622 0.0072992700729927 0.00018478444338478 0.0399968206735547 0.99969806763285 0.998909746529476 0.999963432497808 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 260.309363317448 1 104.5 516 False False 0 0 0 0 0 0 0 24.3455882352941 0.40967031550273 467.794521053941 0 0 0.0267595583791432 0.99969806763285 0.998909746529476 0.999963432497808 3 3) Uncertain significance No change no 1 +Linezolid rrl n.2201T>C rrl_n.2201T>C 1 non_coding_transcript_exon_variant 1475858 0 0 0 0 1 4 372 17435 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.99977062904983 0.999412824358174 0.99993750071294 0.2 0.00505076337946806 0.716417936118089 NA NA NA 0 0 0.602364635616474 NA NA NA NA 475 852 False False 11.7170698924731 0.237290978858699 118.299112140283 0 0 0.00986733780971405 0.99977062904983 0.999412824358174 0.99993750071294 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 137 6621 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 242 516 False False 0 0 0 0 0 0 0 0 0 117.538380750032 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 163 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2209T>A rrl_n.2209T>A 1 non_coding_transcript_exon_variant 1475866 0 0 0 0 1 3 372 17436 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999827971787373 0.999497343686186 0.999964522241709 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 512 852 False False 15.6236559139784 0.296818208001951 195.090770439127 0 0 0.00986733780971405 0.999827971787373 0.999497343686186 0.999964522241709 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 274 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 136 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2209T>G rrl_n.2209T>G 1 non_coding_transcript_exon_variant 1475866 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.2214T>C rrl_n.2214T>C 1 non_coding_transcript_exon_variant 1475871 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 770 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 22 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2220C>A rrl_n.2220C>A 1 non_coding_transcript_exon_variant 1475877 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.2225C>T rrl_n.2225C>T 1 non_coding_transcript_exon_variant 1475882 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Linezolid rrl n.2226A>T rrl_n.2226A>T 1 non_coding_transcript_exon_variant 1475883 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 491 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 257 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 27 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2227A>G rrl_n.2227A>G 1 non_coding_transcript_exon_variant 1475884 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 442 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 217 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 32 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.222dupG rrl_n.222dupG 1 non_coding_transcript_exon_variant 1473878 1 2 0 2 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 249.394754138913 1 45.5 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Linezolid rrl n.2240T>C rrl_n.2240T>C 1 non_coding_transcript_exon_variant 1475897 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 499 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 264 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 22 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2249C>T rrl_n.2249C>T 1 non_coding_transcript_exon_variant 1475906 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 18 3) Uncertain significance No change no 1 +Linezolid rrl n.2259C>G rrl_n.2259C>G 1 non_coding_transcript_exon_variant 1475916 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 521 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 281 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 50 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2259C>T rrl_n.2259C>T 1 non_coding_transcript_exon_variant 1475916 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 522 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 282 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 16 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2269_2270insT rrl_n.2269_2270insT 1 non_coding_transcript_exon_variant 1475926 1 2 1 1 1 1 372 17438 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999942657262457 0.999680548589877 0.999998548208635 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 46.8763440860215 0.595582156681904 3550.80494241025 0.0414445055824385 12 852 False False 46.8763440860215 0.595582156681904 3550.80494241025 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 136 6623 0.0072992700729927 0.00018478444338478 0.0399968206735547 0.999849033816425 0.999159160462165 0.999996177874456 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 48.6985294117647 0.615887122786072 3683.34497751641 0.0401188858130821 7.5 516 False False 0 0 0 0 0 0 0 48.6985294117647 0.615887122786072 3683.34497751641 0.0072992700729927 0.00018478444338478 0.0399968206735547 0.999849033816425 0.999159160462165 0.999996177874456 NA Marker of R Selection evidence 2) Assoc w R - Interim New AwRI yes Selection 5 +Linezolid rrl n.2270G>C rrl_n.2270G>C 1 non_coding_transcript_exon_variant 1475927 NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA Marker of R Selection evidence 2) Assoc w R - Interim New AwRI yes Selection 5 +Linezolid rrl n.2270G>T rrl_n.2270G>T 1 non_coding_transcript_exon_variant 1475927 1 6 4 2 13 4 360 17435 0.03485254691689 0.0186855897997786 0.058861561967005 0.99977062904983 0.999412824358174 0.99993750071294 0.764705882352941 0.501006726795419 0.931892259562643 0.666666666666666 0.222778095503512 0.956728131707258 0.5 0.157012770487058 0.842987229512941 96.8611111111111 13.8098331401318 1062.54728927855 2.49756890949028e-06 3 852 True False 157.399305555555 48.2146124106769 675.196478312336 0.0109890109890109 0.0030020274624915 0.027895787588158 0.99977062904983 0.999412824358174 0.99993750071294 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 2 2 8 4 129 6620 0.0583941605839416 0.0255447451037439 0.111817291497686 0.9993961352657 0.998454594750107 0.999835443455214 0.666666666666666 0.348875506418814 0.900753908850416 0.5 0.067585986488543 0.932414013511457 0.333333333333333 0.0432718682927417 0.777221904496487 51.3178294573643 3.67965503480883 719.59641576271 0.00218428461187038 5 516 False False 0 0 0 0 0 0 0 102.635658914728 26.9524854657138 467.409082389588 0.015267175572519 0.00185430317180599 0.0540613808915615 0.9993961352657 0.998454594750107 0.999835443455214 8 Marker of R Selection evidence 2) Assoc w R - Interim UP from Uncertain to AwRI yes Selection 4 +Linezolid rrl n.2280A>T rrl_n.2280A>T 1 non_coding_transcript_exon_variant 1475937 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 630 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 367 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 30 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2281C>T rrl_n.2281C>T 1 non_coding_transcript_exon_variant 1475938 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2286G>A rrl_n.2286G>A 1 non_coding_transcript_exon_variant 1475943 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 730 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 438 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 58 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.228A>G rrl_n.228A>G 1 non_coding_transcript_exon_variant 1473885 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 3 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2294G>T rrl_n.2294G>T 1 non_coding_transcript_exon_variant 1475951 0 0 0 0 1 0 372 17439 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 1 0.999788491924625 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 662 852 False False Inf 1.19880183801736 Inf 0 0 0.00986733780971405 1 0.999788491924625 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 136 6624 0.0072992700729927 0.00018478444338478 0.0399968206735547 1 0.99944325898497 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 389 516 False False 0 0 0 0 0 0 0 Inf 1.23975059493345 Inf 0 0 0.0267595583791432 1 0.99944325898497 1 NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2295A>C rrl_n.2295A>C 1 non_coding_transcript_exon_variant 1475952 0 0 0 0 5 1 368 17438 0.0134048257372654 0.00436645369297377 0.0310035844605445 0.999942657262457 0.999680548589877 0.999998548208635 0.833333333333333 0.358765421002325 0.99578925548551 NA NA NA 0 0 0.975 NA NA NA NA 523 852 False False 236.929347826086 26.3589724645743 10270.1987797687 0 0 0.00997405482694635 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 1 133 6623 0.0291970802919708 0.00801135704752468 0.0730678323967123 0.999849033816425 0.999159160462165 0.999996177874456 0.8 0.28358206388191 0.994949236620532 NA NA NA 0 0 0.975 NA NA NA NA 283 516 False False 0 0 0 0 0 0 0 199.187969924812 19.4258293641238 9075.71504363663 0 0 0.0273548262840436 0.999849033816425 0.999159160462165 0.999996177874456 1 3) Uncertain significance No change no 1 +Linezolid rrl n.2295A>G rrl_n.2295A>G 1 non_coding_transcript_exon_variant 1475952 1 0 0 0 0 3 373 17436 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 688 852 False False 0 0 113.680929631125 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 137 6621 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 407 516 False False 0 0 0 0 0 0 0 0 0 117.538380750032 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 63 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2296A>C rrl_n.2296A>C 1 non_coding_transcript_exon_variant 1475953 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2296A>G rrl_n.2296A>G 1 non_coding_transcript_exon_variant 1475953 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 553 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2296A>T rrl_n.2296A>T 1 non_coding_transcript_exon_variant 1475953 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 757 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.2297A>G rrl_n.2297A>G 1 non_coding_transcript_exon_variant 1475954 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Linezolid rrl n.2299G>T rrl_n.2299G>T 1 non_coding_transcript_exon_variant 1475956 1 1 1 0 1 0 372 17439 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 1 0.999788491924625 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 1.19880183801736 Inf 0.0209409386930159 8.5 852 False False Inf 1.19880183801736 Inf 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 1 0.999788491924625 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Marker of R Selection evidence 2) Assoc w R - Interim New AwRI yes Selection 5 +Linezolid rrl n.22T>C rrl_n.22T>C 1 non_coding_transcript_exon_variant 1473679 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 792 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.230T>C rrl_n.230T>C 1 non_coding_transcript_exon_variant 1473887 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 586 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 331 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 4 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2313C>T rrl_n.2313C>T 1 non_coding_transcript_exon_variant 1475970 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 569 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 316 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 47 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2314A>G rrl_n.2314A>G 1 non_coding_transcript_exon_variant 1475971 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance No change no 1 +Linezolid rrl n.2317A>G rrl_n.2317A>G 1 non_coding_transcript_exon_variant 1475974 1 2 0 2 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 249.394754138913 1 45.5 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Linezolid rrl n.2318C>T rrl_n.2318C>T 1 non_coding_transcript_exon_variant 1475975 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 476 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 243 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 33 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.231T>A rrl_n.231T>A 1 non_coding_transcript_exon_variant 1473888 1 0 0 0 0 3 373 17436 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 513 852 False False 0 0 113.680929631125 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 137 6621 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 275 516 False False 0 0 0 0 0 0 0 0 0 117.538380750032 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 46 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.231T>C rrl_n.231T>C 1 non_coding_transcript_exon_variant 1473888 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 457 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 229 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 3 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2320A>G rrl_n.2320A>G 1 non_coding_transcript_exon_variant 1475977 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 477 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 244 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 42 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2321C>T rrl_n.2321C>T 1 non_coding_transcript_exon_variant 1475978 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 415 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 199 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 24 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2331A>G rrl_n.2331A>G 1 non_coding_transcript_exon_variant 1475988 1 4 0 4 0 7 373 17432 0 0 0.0098410144176726 0.999598600837204 0.99917314031148 0.999838601975561 0 0 0.409616397225003 0 0 0.602364635616474 0 0 0.409616397225003 0 0 70.9717157792826 1 232 852 False False 0 0 32.5355852264781 0 0 0.0098410144176726 0.999598600837204 0.99917314031148 0.999838601975561 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 7 137 6617 0 0 0.0265668510962833 0.998943236714976 0.997823883513531 0.999575024140687 0 0 0.409616397225003 0 0 0.602364635616474 0 0 0.409616397225003 0 0 73.6667223207558 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 33.8487376789655 0 0 0.0265668510962833 0.998943236714976 0.997823883513531 0.999575024140687 55 3) Uncertain significance No change no 1 +Linezolid rrl n.2336C>T rrl_n.2336C>T 1 non_coding_transcript_exon_variant 1475993 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 428 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 16 3) Uncertain significance No change no 1 +Linezolid rrl n.2340A>T rrl_n.2340A>T 1 non_coding_transcript_exon_variant 1475997 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 570 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 317 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 20 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2341C>A rrl_n.2341C>A 1 non_coding_transcript_exon_variant 1475998 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance No change no 1 +Linezolid rrl n.2341C>T rrl_n.2341C>T 1 non_coding_transcript_exon_variant 1475998 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 554 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 12 3) Uncertain significance No change no 1 +Linezolid rrl n.2344T>C rrl_n.2344T>C 1 non_coding_transcript_exon_variant 1476001 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 555 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 306 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 28 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2350T>G rrl_n.2350T>G 1 non_coding_transcript_exon_variant 1476007 1 3 0 3 0 3 373 17436 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 113.680929631125 1 232 852 False False 0 0 113.680929631125 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 5 3) Uncertain significance No change no 1 +Linezolid rrl n.2368G>A rrl_n.2368G>A 1 non_coding_transcript_exon_variant 1476025 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Linezolid rrl n.236T>C rrl_n.236T>C 1 non_coding_transcript_exon_variant 1473893 1 5 0 5 0 5 373 17434 0 0 0.0098410144176726 0.999713286312288 0.999331033812208 0.999906898501965 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 51.1583852845118 1 45.5 852 False False 0 0 51.1583852845118 0 0 0.0098410144176726 0.999713286312288 0.999331033812208 0.999906898501965 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance No change no 1 +Linezolid rrl n.2392C>T rrl_n.2392C>T 1 non_coding_transcript_exon_variant 1476049 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 670 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 394 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 23 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2399G>A rrl_n.2399G>A 1 non_coding_transcript_exon_variant 1476056 1 116 1 115 4 117 369 17322 0.0107238605898123 0.00292940583237432 0.0272283425629702 0.993290899707552 0.991964679161162 0.994448324380884 0.0330578512396694 0.00907923114599569 0.082479381167131 0.00862068965517241 0.000218233149063064 0.0470955362266474 0.00847457627118644 0.000214534678926028 0.0463127279051031 0.40820077765995 0.010222242136113 2.33437714385682 0.73645012019355 19 852 False False 1.60489194635536 0.427820519360543 4.25467852490646 0.0027027027027027 6.8424167025542e-05 0.0149657944350072 0.993290899707552 0.991964679161162 0.994448324380884 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 27 0 27 1 27 136 6597 0.0072992700729927 0.00018478444338478 0.0399968206735547 0.995923913043478 0.994075008156561 0.997312166535201 0.0357142857142857 0.000903798755658059 0.183477597544623 0 0 0.127702867615432 0 0 0.127702867615432 0 0 7.1918015279876 1 104.5 516 False False 0 0 0 0 0 0 0 1.79656862745098 0.04356419543141 11.0628545925175 0 0 0.0267595583791432 0.995923913043478 0.994075008156561 0.997312166535201 170 3) Uncertain significance No change no 1 +Linezolid rrl n.2401T>C rrl_n.2401T>C 1 non_coding_transcript_exon_variant 1476058 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 536 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 293 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 9 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.241C>G rrl_n.241C>G 1 non_coding_transcript_exon_variant 1473898 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 631 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 368 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 3 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.241C>T rrl_n.241C>T 1 non_coding_transcript_exon_variant 1473898 1 1 0 1 0 3 373 17436 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 1772.7002684543 1 232 852 False False 0 0 113.680929631125 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 137 6621 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 1831.18661936844 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 117.538380750032 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 51 3) Uncertain significance No change no 1 +Linezolid rrl n.2421C>A rrl_n.2421C>A 1 non_coding_transcript_exon_variant 1476078 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.2429G>A rrl_n.2429G>A 1 non_coding_transcript_exon_variant 1476086 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 443 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 218 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 6 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.242A>C rrl_n.242A>C 1 non_coding_transcript_exon_variant 1473899 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 444 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 219 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 29 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.242A>G rrl_n.242A>G 1 non_coding_transcript_exon_variant 1473899 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 689 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 408 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 16 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2431A>C rrl_n.2431A>C 1 non_coding_transcript_exon_variant 1476088 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 401 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 189 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 4 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2434T>C rrl_n.2434T>C 1 non_coding_transcript_exon_variant 1476091 1 4 0 4 2 4 371 17435 0.00536193029490616 0.000650015532491959 0.019233955575368 0.99977062904983 0.999412824358174 0.99993750071294 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.602364635616474 0 0 0.602364635616474 0 0 71.3671593667249 1 45.5 852 False False 23.4973045822102 2.11756217816054 164.913102849154 0 0 0.00989380240135706 0.99977062904983 0.999412824358174 0.99993750071294 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 2 3 135 6621 0.0145985401459854 0.00177286642699366 0.0517388975821079 0.999547101449275 0.998677014323056 0.999906591690576 0.4 0.0527449505263169 0.853367200365326 0 0 0.707598226178713 0 0 0.707598226178713 0 0 119.284092896071 1 16.5 516 False False 0 0 0 0 0 0 0 32.6962962962962 2.70284901106193 286.433261613261 0 0 0.0269550815831828 0.999547101449275 0.998677014323056 0.999906591690576 30 3) Uncertain significance No change no 1 +Linezolid rrl n.2442A>G rrl_n.2442A>G 1 non_coding_transcript_exon_variant 1476099 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 671 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 395 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 6 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2444C>T rrl_n.2444C>T 1 non_coding_transcript_exon_variant 1476101 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2446_2449delCTGAinsATG rrl_n.2446_2449delCTGAinsATG 1 non_coding_transcript_exon_variant 1476103 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 620 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 358 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 1 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2453G>A rrl_n.2453G>A 1 non_coding_transcript_exon_variant 1476110 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 2 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2453G>T rrl_n.2453G>T 1 non_coding_transcript_exon_variant 1476110 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 492 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 258 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 3 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2454G>A rrl_n.2454G>A 1 non_coding_transcript_exon_variant 1476111 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance No change no 1 +Linezolid rrl n.2457T>C rrl_n.2457T>C 1 non_coding_transcript_exon_variant 1476114 1 2 0 2 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 249.394754138913 1 45.5 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 2 3) Uncertain significance No change no 1 +Linezolid rrl n.2458T>C rrl_n.2458T>C 1 non_coding_transcript_exon_variant 1476115 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 587 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 332 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 12 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2461G>A rrl_n.2461G>A 1 non_coding_transcript_exon_variant 1476118 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2465A>T rrl_n.2465A>T 1 non_coding_transcript_exon_variant 1476122 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.2467T>C rrl_n.2467T>C 1 non_coding_transcript_exon_variant 1476124 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.2468G>A rrl_n.2468G>A 1 non_coding_transcript_exon_variant 1476125 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2469C>T rrl_n.2469C>T 1 non_coding_transcript_exon_variant 1476126 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 712 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 424 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 37 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2472G>A rrl_n.2472G>A 1 non_coding_transcript_exon_variant 1476129 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.2473G>A rrl_n.2473G>A 1 non_coding_transcript_exon_variant 1476130 1 0 0 0 0 3 373 17436 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 804 852 False False 0 0 113.680929631125 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 137 6621 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 489 516 False False 0 0 0 0 0 0 0 0 0 117.538380750032 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 64 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2474C>T rrl_n.2474C>T 1 non_coding_transcript_exon_variant 1476131 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 702 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 415 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 54 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2478T>C rrl_n.2478T>C 1 non_coding_transcript_exon_variant 1476135 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 416 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 200 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 57 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2479A>G rrl_n.2479A>G 1 non_coding_transcript_exon_variant 1476136 1 2 0 2 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 249.394754138913 1 45.5 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Linezolid rrl n.2484A>G rrl_n.2484A>G 1 non_coding_transcript_exon_variant 1476141 0 0 0 0 1 2 372 17437 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999885314524915 0.999585778685812 0.999986110755134 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 537 852 False False 23.4368279569892 0.396197405925517 449.369433886118 0 0 0.00986733780971405 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 294 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 147 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2496T>C rrl_n.2496T>C 1 non_coding_transcript_exon_variant 1476153 0 0 0 0 1 2 372 17437 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999885314524915 0.999585778685812 0.999986110755134 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 663 852 False False 23.4368279569892 0.396197405925517 449.369433886118 0 0 0.00986733780971405 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 390 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 151 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2503T>C rrl_n.2503T>C 1 non_coding_transcript_exon_variant 1476160 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 429 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 207 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 13 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2503T>G rrl_n.2503T>G 1 non_coding_transcript_exon_variant 1476160 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Linezolid rrl n.2507A>G rrl_n.2507A>G 1 non_coding_transcript_exon_variant 1476164 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 576 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 322 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 47 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2508T>A rrl_n.2508T>A 1 non_coding_transcript_exon_variant 1476165 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 402 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 190 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 33 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2508T>G rrl_n.2508T>G 1 non_coding_transcript_exon_variant 1476165 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 621 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 359 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 125 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2509G>C rrl_n.2509G>C 1 non_coding_transcript_exon_variant 1476166 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.251C>G rrl_n.251C>G 1 non_coding_transcript_exon_variant 1473908 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 1 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2529T>C rrl_n.2529T>C 1 non_coding_transcript_exon_variant 1476186 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance No change no 1 +Linezolid rrl n.2537A>G rrl_n.2537A>G 1 non_coding_transcript_exon_variant 1476194 1 1 0 1 0 5 373 17434 0 0 0.0098410144176726 0.999713286312288 0.999331033812208 0.999906898501965 0 0 0.521823750104981 0 0 0.975 0 0 0.521823750104981 0 0 1772.5025733566 1 232 852 False False 0 0 51.1583852845118 0 0 0.0098410144176726 0.999713286312288 0.999331033812208 0.999906898501965 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 137 6621 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 276 516 False False 0 0 0 0 0 0 0 0 0 117.538380750032 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 99 3) Uncertain significance No change no 1 +Linezolid rrl n.2538C>A rrl_n.2538C>A 1 non_coding_transcript_exon_variant 1476195 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 664 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 37 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2539C>A rrl_n.2539C>A 1 non_coding_transcript_exon_variant 1476196 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 514 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 37 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2543A>T rrl_n.2543A>T 1 non_coding_transcript_exon_variant 1476200 1 0 0 0 0 4 373 17435 0 0 0.0098410144176726 0.99977062904983 0.999412824358174 0.99993750071294 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 515 852 False False 0 0 70.9839175273221 0 0 0.0098410144176726 0.99977062904983 0.999412824358174 0.99993750071294 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 137 6621 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 277 516 False False 0 0 0 0 0 0 0 0 0 117.538380750032 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 94 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2544C>T rrl_n.2544C>T 1 non_coding_transcript_exon_variant 1476201 1 0 0 0 0 3 373 17436 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 524 852 False False 0 0 113.680929631125 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 284 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 90 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2547C>A rrl_n.2547C>A 1 non_coding_transcript_exon_variant 1476204 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 599 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 37 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2553G>T rrl_n.2553G>T 1 non_coding_transcript_exon_variant 1476210 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 430 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 34 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2554G>T rrl_n.2554G>T 1 non_coding_transcript_exon_variant 1476211 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 672 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 34 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2555T>C rrl_n.2555T>C 1 non_coding_transcript_exon_variant 1476212 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 516 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 35 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2557G>C rrl_n.2557G>C 1 non_coding_transcript_exon_variant 1476214 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 690 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 30 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2557G>T rrl_n.2557G>T 1 non_coding_transcript_exon_variant 1476214 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 600 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 343 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 43 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2558C>A rrl_n.2558C>A 1 non_coding_transcript_exon_variant 1476215 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 417 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 35 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2558C>T rrl_n.2558C>T 1 non_coding_transcript_exon_variant 1476215 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 538 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 295 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 34 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2564T>C rrl_n.2564T>C 1 non_coding_transcript_exon_variant 1476221 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 577 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 323 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 7 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2565A>C rrl_n.2565A>C 1 non_coding_transcript_exon_variant 1476222 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Linezolid rrl n.2567A>G rrl_n.2567A>G 1 non_coding_transcript_exon_variant 1476224 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 578 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 324 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 61 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2568T>G rrl_n.2568T>G 1 non_coding_transcript_exon_variant 1476225 0 0 0 0 1 1 372 17438 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999942657262457 0.999680548589877 0.999998548208635 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 601 852 False False 46.8763440860215 0.595582156681904 3550.80494241025 0 0 0.00986733780971405 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 107 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2570C>T rrl_n.2570C>T 1 non_coding_transcript_exon_variant 1476227 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 10 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2586T>C rrl_n.2586T>C 1 non_coding_transcript_exon_variant 1476243 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 418 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2588C>T rrl_n.2588C>T 1 non_coding_transcript_exon_variant 1476245 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 493 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 259 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 49 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2593C>G rrl_n.2593C>G 1 non_coding_transcript_exon_variant 1476250 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 458 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 230 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 71 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2594T>A rrl_n.2594T>A 1 non_coding_transcript_exon_variant 1476251 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 816 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 499 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 13 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2594T>C rrl_n.2594T>C 1 non_coding_transcript_exon_variant 1476251 0 0 0 0 1 3 372 17436 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999827971787373 0.999497343686186 0.999964522241709 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 793 852 False False 15.6236559139784 0.296818208001951 195.090770439127 0 0 0.00986733780971405 0.999827971787373 0.999497343686186 0.999964522241709 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 482 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 174 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2595T>G rrl_n.2595T>G 1 non_coding_transcript_exon_variant 1476252 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 713 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 425 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 46 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2599A>G rrl_n.2599A>G 1 non_coding_transcript_exon_variant 1476256 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 539 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 296 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 28 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2599A>T rrl_n.2599A>T 1 non_coding_transcript_exon_variant 1476256 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 703 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 416 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 12 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.259C>A rrl_n.259C>A 1 non_coding_transcript_exon_variant 1473916 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 588 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 333 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 11 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.-25C>T rrl_n.-25C>T 1 upstream_gene_variant 1473633 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Linezolid rrl n.2600G>C rrl_n.2600G>C 1 non_coding_transcript_exon_variant 1476257 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 771 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 464 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 96 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2602C>G rrl_n.2602C>G 1 non_coding_transcript_exon_variant 1476259 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 540 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 297 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 2 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2603A>G rrl_n.2603A>G 1 non_coding_transcript_exon_variant 1476260 0 0 0 0 1 6 372 17433 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999655943574746 0.999251285574099 0.999873727224798 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA 0 0 0.4592581264399 NA NA NA NA 805 852 False False 7.81048387096774 0.169351813995106 64.6351898930483 0 0 0.00986733780971405 0.999655943574746 0.999251285574099 0.999873727224798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 137 6620 0 0 0.0265668510962833 0.9993961352657 0.998454594750107 0.999835443455214 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 490 516 False False 0 0 0 0 0 0 0 0 0 73.7000674034286 0 0 0.0265668510962833 0.9993961352657 0.998454594750107 0.999835443455214 267 3) Uncertain significance No change no 1 +Linezolid rrl n.2623A>C rrl_n.2623A>C 1 non_coding_transcript_exon_variant 1476280 0 0 0 0 1 5 372 17434 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999713286312288 0.999331033812208 0.999906898501965 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA 0 0 0.521823750104981 NA NA NA NA 579 852 False False 9.37311827956989 0.197647887799225 83.9243955038524 0 0 0.00986733780971405 0.999713286312288 0.999331033812208 0.999906898501965 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 137 6621 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 325 516 False False 0 0 0 0 0 0 0 0 0 117.538380750032 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 209 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2624T>C rrl_n.2624T>C 1 non_coding_transcript_exon_variant 1476281 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 645 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 375 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 43 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2633C>A rrl_n.2633C>A 1 non_coding_transcript_exon_variant 1476290 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2636C>T rrl_n.2636C>T 1 non_coding_transcript_exon_variant 1476293 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 794 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 483 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 85 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2637A>G rrl_n.2637A>G 1 non_coding_transcript_exon_variant 1476294 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 714 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 426 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 94 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2638C>G rrl_n.2638C>G 1 non_coding_transcript_exon_variant 1476295 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 715 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 427 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 96 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2639C>T rrl_n.2639C>T 1 non_coding_transcript_exon_variant 1476296 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 602 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 344 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 96 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2640C>A rrl_n.2640C>A 1 non_coding_transcript_exon_variant 1476297 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 806 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 491 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 11 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2640C>G rrl_n.2640C>G 1 non_coding_transcript_exon_variant 1476297 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 632 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 369 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 7 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2640C>T rrl_n.2640C>T 1 non_coding_transcript_exon_variant 1476297 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 691 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 84 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2641C>G rrl_n.2641C>G 1 non_coding_transcript_exon_variant 1476298 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 500 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 265 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 6 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2642C>T rrl_n.2642C>T 1 non_coding_transcript_exon_variant 1476299 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 6 3) Uncertain significance No change no 1 +Linezolid rrl n.2643G>A rrl_n.2643G>A 1 non_coding_transcript_exon_variant 1476300 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 817 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 500 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2644A>C rrl_n.2644A>C 1 non_coding_transcript_exon_variant 1476301 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 673 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 70 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2644A>T rrl_n.2644A>T 1 non_coding_transcript_exon_variant 1476301 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 758 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 458 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 22 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2645G>A rrl_n.2645G>A 1 non_coding_transcript_exon_variant 1476302 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 772 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 465 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 80 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2652G>C rrl_n.2652G>C 1 non_coding_transcript_exon_variant 1476309 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 501 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 266 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 8 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2654G>C rrl_n.2654G>C 1 non_coding_transcript_exon_variant 1476311 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 603 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 345 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 104 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2655T>C rrl_n.2655T>C 1 non_coding_transcript_exon_variant 1476312 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 589 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 334 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 104 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2656G>A rrl_n.2656G>A 1 non_coding_transcript_exon_variant 1476313 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 502 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 267 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 90 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.266C>A rrl_n.266C>A 1 non_coding_transcript_exon_variant 1473923 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Linezolid rrl n.266C>G rrl_n.266C>G 1 non_coding_transcript_exon_variant 1473923 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 646 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 376 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 27 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.266C>T rrl_n.266C>T 1 non_coding_transcript_exon_variant 1473923 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance No change no 1 +Linezolid rrl n.2675G>C rrl_n.2675G>C 1 non_coding_transcript_exon_variant 1476332 0 0 0 0 1 4 372 17435 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.99977062904983 0.999412824358174 0.99993750071294 0.2 0.00505076337946806 0.716417936118089 NA NA NA 0 0 0.602364635616474 NA NA NA NA 541 852 False False 11.7170698924731 0.237290978858699 118.299112140283 0 0 0.00986733780971405 0.99977062904983 0.999412824358174 0.99993750071294 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 298 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 182 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2680C>T rrl_n.2680C>T 1 non_coding_transcript_exon_variant 1476337 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 807 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 492 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 16 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2681C>T rrl_n.2681C>T 1 non_coding_transcript_exon_variant 1476338 1 1 0 1 0 4 373 17435 0 0 0.0098410144176726 0.99977062904983 0.999412824358174 0.99993750071294 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 1772.60142106247 1 394.5 852 False False 0 0 70.9839175273221 0 0 0.0098410144176726 0.99977062904983 0.999412824358174 0.99993750071294 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 137 6621 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 1831.18661936844 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 117.538380750032 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 99 3) Uncertain significance No change no 1 +Linezolid rrl n.2689A>T rrl_n.2689A>T 1 non_coding_transcript_exon_variant 1476346 NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA Marker of R Selection evidence 2) Assoc w R - Interim New AwRI yes Selection 5 +Linezolid rrl n.2691A>T rrl_n.2691A>T 1 non_coding_transcript_exon_variant 1476348 1 1 0 1 2 1 371 17438 0.00536193029490616 0.000650015532491959 0.019233955575368 0.999942657262457 0.999680548589877 0.999998548208635 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 1782.18922155694 1 232 852 False False 94.0053908355795 4.87516991021522 5292.01172125943 0 0 0.00989380240135706 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 2 2 0 2 0 135 6624 0.0145985401459854 0.00177286642699366 0.0517388975821079 1 0.99944325898497 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 9.11837102321429 Inf 0.000407663513940464 4 516 False False 0 0 0 0 0 0 0 Inf 9.11837102321429 Inf 0.0145985401459854 0.00177286642699366 0.0517388975821079 1 0.99944325898497 1 2 3) Uncertain significance No change no 1 +Linezolid rrl n.2696G>T rrl_n.2696G>T 1 non_coding_transcript_exon_variant 1476353 0 0 0 0 1 3 372 17436 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999827971787373 0.999497343686186 0.999964522241709 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 403 852 False False 15.6236559139784 0.296818208001951 195.090770439127 0 0 0.00986733780971405 0.999827971787373 0.999497343686186 0.999964522241709 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 191 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 190 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.269G>C rrl_n.269G>C 1 non_coding_transcript_exon_variant 1473926 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 647 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 377 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 23 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.26G>A rrl_n.26G>A 1 non_coding_transcript_exon_variant 1473683 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance No change no 1 +Linezolid rrl n.2701T>C rrl_n.2701T>C 1 non_coding_transcript_exon_variant 1476358 0 0 0 0 1 5 372 17434 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999713286312288 0.999331033812208 0.999906898501965 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA 0 0 0.521823750104981 NA NA NA NA 808 852 False False 9.37311827956989 0.197647887799225 83.9243955038524 0 0 0.00986733780971405 0.999713286312288 0.999331033812208 0.999906898501965 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 137 6621 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 493 516 False False 0 0 0 0 0 0 0 0 0 117.538380750032 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 217 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2702C>G rrl_n.2702C>G 1 non_coding_transcript_exon_variant 1476359 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 731 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 439 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 100 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2712C>T rrl_n.2712C>T 1 non_coding_transcript_exon_variant 1476369 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 779 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 472 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 146 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2715T>C rrl_n.2715T>C 1 non_coding_transcript_exon_variant 1476372 0 0 0 0 1 4 372 17435 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.99977062904983 0.999412824358174 0.99993750071294 0.2 0.00505076337946806 0.716417936118089 NA NA NA 0 0 0.602364635616474 NA NA NA NA 648 852 False False 11.7170698924731 0.237290978858699 118.299112140283 0 0 0.00986733780971405 0.99977062904983 0.999412824358174 0.99993750071294 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 378 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 195 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.271T>C rrl_n.271T>C 1 non_coding_transcript_exon_variant 1473928 1 2 0 2 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 249.394754138913 1 45.5 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Linezolid rrl n.2724G>C rrl_n.2724G>C 1 non_coding_transcript_exon_variant 1476381 1 0 0 0 0 4 373 17435 0 0 0.0098410144176726 0.99977062904983 0.999412824358174 0.99993750071294 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 732 852 False False 0 0 70.9839175273221 0 0 0.0098410144176726 0.99977062904983 0.999412824358174 0.99993750071294 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 137 6620 0 0 0.0265668510962833 0.9993961352657 0.998454594750107 0.999835443455214 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 440 516 False False 0 0 0 0 0 0 0 0 0 73.7000674034286 0 0 0.0265668510962833 0.9993961352657 0.998454594750107 0.999835443455214 133 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2725A>G rrl_n.2725A>G 1 non_coding_transcript_exon_variant 1476382 0 0 0 0 1 4 372 17435 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.99977062904983 0.999412824358174 0.99993750071294 0.2 0.00505076337946806 0.716417936118089 NA NA NA 0 0 0.602364635616474 NA NA NA NA 604 852 False False 11.7170698924731 0.237290978858699 118.299112140283 0 0 0.00986733780971405 0.99977062904983 0.999412824358174 0.99993750071294 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 346 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 220 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2726T>A rrl_n.2726T>A 1 non_coding_transcript_exon_variant 1476383 0 0 0 0 1 4 372 17435 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.99977062904983 0.999412824358174 0.99993750071294 0.2 0.00505076337946806 0.716417936118089 NA NA NA 0 0 0.602364635616474 NA NA NA NA 478 852 False False 11.7170698924731 0.237290978858699 118.299112140283 0 0 0.00986733780971405 0.99977062904983 0.999412824358174 0.99993750071294 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 245 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 210 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2746G>A rrl_n.2746G>A 1 non_coding_transcript_exon_variant 1476403 NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA Marker of R Selection evidence 2) Assoc w R - Interim New AwRI yes Selection 5 +Linezolid rrl n.2751G>A rrl_n.2751G>A 1 non_coding_transcript_exon_variant 1476408 0 0 0 0 1 2 372 17437 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999885314524915 0.999585778685812 0.999986110755134 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 622 852 False False 23.4368279569892 0.396197405925517 449.369433886118 0 0 0.00986733780971405 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 153 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2755C>T rrl_n.2755C>T 1 non_coding_transcript_exon_variant 1476412 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance No change no 1 +Linezolid rrl n.2766T>C rrl_n.2766T>C 1 non_coding_transcript_exon_variant 1476423 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 525 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 285 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance No change no 1 +Linezolid rrl n.2768G>A rrl_n.2768G>A 1 non_coding_transcript_exon_variant 1476425 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 773 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 466 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 29 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2768G>T rrl_n.2768G>T 1 non_coding_transcript_exon_variant 1476425 0 0 0 0 1 2 372 17437 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999885314524915 0.999585778685812 0.999986110755134 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 431 852 False False 23.4368279569892 0.396197405925517 449.369433886118 0 0 0.00986733780971405 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 208 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 169 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.276C>T rrl_n.276C>T 1 non_coding_transcript_exon_variant 1473933 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 479 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Linezolid rrl n.2771C>T rrl_n.2771C>T 1 non_coding_transcript_exon_variant 1476428 0 0 0 0 1 7 372 17432 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999598600837204 0.99917314031148 0.999838601975561 0.125 0.0031597235312519 0.526509670875206 NA NA NA 0 0 0.409616397225003 NA NA NA NA 716 852 False False 6.69431643625192 0.148140918599462 52.3506471819898 0 0 0.00986733780971405 0.999598600837204 0.99917314031148 0.999838601975561 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 137 6619 0 0 0.0265668510962833 0.999245169082125 0.998239362946804 0.999754864475697 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 428 516 False False 0 0 0 0 0 0 0 0 0 53.1553319379921 0 0 0.0265668510962833 0.999245169082125 0.998239362946804 0.999754864475697 296 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2772A>C rrl_n.2772A>C 1 non_coding_transcript_exon_variant 1476429 0 0 0 0 1 4 372 17435 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.99977062904983 0.999412824358174 0.99993750071294 0.2 0.00505076337946806 0.716417936118089 NA NA NA 0 0 0.602364635616474 NA NA NA NA 795 852 False False 11.7170698924731 0.237290978858699 118.299112140283 0 0 0.00986733780971405 0.99977062904983 0.999412824358174 0.99993750071294 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 137 6621 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 484 516 False False 0 0 0 0 0 0 0 0 0 117.538380750032 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 227 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2779A>G rrl_n.2779A>G 1 non_coding_transcript_exon_variant 1476436 1 6 0 6 0 6 373 17433 0 0 0.0098410144176726 0.999655943574746 0.999251285574099 0.999873727224798 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 39.8653094124675 1 232 852 False False 0 0 39.8653094124675 0 0 0.0098410144176726 0.999655943574746 0.999251285574099 0.999873727224798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 137 6620 0 0 0.0265668510962833 0.9993961352657 0.998454594750107 0.999835443455214 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 73.7000674034286 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 73.7000674034286 0 0 0.0265668510962833 0.9993961352657 0.998454594750107 0.999835443455214 12 3) Uncertain significance No change no 1 +Linezolid rrl n.2781G>A rrl_n.2781G>A 1 non_coding_transcript_exon_variant 1476438 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 2 3) Uncertain significance No change no 1 +Linezolid rrl n.2790T>C rrl_n.2790T>C 1 non_coding_transcript_exon_variant 1476447 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 633 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.-27T>G rrl_n.-27T>G 1 upstream_gene_variant 1473631 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.2809C>T rrl_n.2809C>T 1 non_coding_transcript_exon_variant 1476466 0 0 0 0 1 5 372 17434 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999713286312288 0.999331033812208 0.999906898501965 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA 0 0 0.521823750104981 NA NA NA NA 556 852 False False 9.37311827956989 0.197647887799225 83.9243955038524 0 0 0.00986733780971405 0.999713286312288 0.999331033812208 0.999906898501965 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 307 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 234 3) Uncertain significance No change no 1 +Linezolid rrl n.280C>G rrl_n.280C>G 1 non_coding_transcript_exon_variant 1473937 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 1 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2810A>C rrl_n.2810A>C 1 non_coding_transcript_exon_variant 1476467 1 1 1 0 3 0 370 17439 0.00804289544235925 0.00166171954284036 0.0233236515558583 1 0.999788491924625 1 1 0.292401773821286 1 1 0.025 1 1 0.025 1 Inf 1.20526432745363 Inf 0.0208309938236945 6 852 False False Inf 19.3772485178075 Inf 0.00269541778975741 6.82397416014217e-05 0.0149257036827482 1 0.999788491924625 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 3 0 134 6624 0.0218978102189781 0.00453882266370741 0.0626599862608879 1 0.99944325898497 1 1 0.292401773821286 1 1 0.025 1 1 0.025 1 Inf 1.25811724416404 Inf 0.0199733688415445 6 516 False False 0 0 0 0 0 0 0 Inf 20.159449953668 Inf 0.0074074074074074 0.000187521734003446 0.0405793591160869 1 0.99944325898497 1 NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2813C>T rrl_n.2813C>T 1 non_coding_transcript_exon_variant 1476470 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 22 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2814G>T rrl_n.2814G>T 1 non_coding_transcript_exon_variant 1476471 1 9 7 2 19 4 354 17435 0.0509383378016085 0.0309432287785106 0.0784057705430451 0.99977062904983 0.999412824358174 0.99993750071294 0.826086956521739 0.612188110045202 0.950492354694206 0.777777777777777 0.399906426283687 0.971855026522101 0.636363636363636 0.307904715011677 0.890736556180901 172.379943502824 32.5901761023121 1803.59435241562 4.63549746048572e-11 2 852 True False 233.944209039548 77.0388818597085 928.811303329578 0.0193905817174515 0.00783069425517453 0.0395422684969207 0.99977062904983 0.999412824358174 0.99993750071294 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance 1 7 5 2 15 4 122 6620 0.10948905109489 0.0625898454527768 0.174150002381647 0.9993961352657 0.998454594750107 0.999835443455214 0.789473684210526 0.544346918108494 0.93947546229071 0.714285714285714 0.290420863737342 0.963307433823914 0.555555555555555 0.212008506778868 0.863004337734833 135.655737704918 21.8263088914335 1334.11773735845 4.44513690013204e-08 2 516 True False 0 0 0 0 0 0 0 203.483606557377 63.1463244758786 835.862415603534 0.0393700787401574 0.0129049551017199 0.0894851478973127 0.9993961352657 0.998454594750107 0.999835443455214 6 Marker of R Evidence from ALL dataset only 2) Assoc w R - Interim UP from Uncertain to AwRI yes ALL only 4 +Linezolid rrl n.2824T>C rrl_n.2824T>C 1 non_coding_transcript_exon_variant 1476481 0 0 0 0 2 8 371 17431 0.00536193029490616 0.000650015532491959 0.019233955575368 0.999541258099661 0.999096296761143 0.99980192766755 0.2 0.0252107263268333 0.556095462307641 NA NA NA 0 0 0.369416647552819 NA NA NA NA 649 852 False False 11.7459568733153 1.21055889526861 59.0648280782765 0 0 0.00989380240135706 0.999541258099661 0.999096296761143 0.99980192766755 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 6 136 6618 0.0072992700729927 0.00018478444338478 0.0399968206735547 0.99909420289855 0.998029511465385 0.999667518193072 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA 0 0 0.4592581264399 NA NA NA NA 379 516 False False 0 0 0 0 0 0 0 8.11029411764705 0.175047096530994 67.6158472277094 0 0 0.0267595583791432 0.99909420289855 0.998029511465385 0.999667518193072 296 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2828A>G rrl_n.2828A>G 1 non_coding_transcript_exon_variant 1476485 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 717 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.2844C>T rrl_n.2844C>T 1 non_coding_transcript_exon_variant 1476501 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 3 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2849T>C rrl_n.2849T>C 1 non_coding_transcript_exon_variant 1476506 0 0 0 0 2 8 371 17431 0.00536193029490616 0.000650015532491959 0.019233955575368 0.999541258099661 0.999096296761143 0.99980192766755 0.2 0.0252107263268333 0.556095462307641 NA NA NA 0 0 0.369416647552819 NA NA NA NA 542 852 False False 11.7459568733153 1.21055889526861 59.0648280782765 0 0 0.00989380240135706 0.999541258099661 0.999096296761143 0.99980192766755 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 6 136 6618 0.0072992700729927 0.00018478444338478 0.0399968206735547 0.99909420289855 0.998029511465385 0.999667518193072 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA 0 0 0.4592581264399 NA NA NA NA 299 516 False False 0 0 0 0 0 0 0 8.11029411764705 0.175047096530994 67.6158472277094 0 0 0.0267595583791432 0.99909420289855 0.998029511465385 0.999667518193072 277 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.284T>C rrl_n.284T>C 1 non_coding_transcript_exon_variant 1473941 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.2857C>T rrl_n.2857C>T 1 non_coding_transcript_exon_variant 1476514 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 747 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 72 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.285G>C rrl_n.285G>C 1 non_coding_transcript_exon_variant 1473942 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance No change no 1 +Linezolid rrl n.2862C>G rrl_n.2862C>G 1 non_coding_transcript_exon_variant 1476519 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 557 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 72 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2862C>T rrl_n.2862C>T 1 non_coding_transcript_exon_variant 1476519 1 2 0 2 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 249.394754138913 1 45.5 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Linezolid rrl n.2866T>C rrl_n.2866T>C 1 non_coding_transcript_exon_variant 1476523 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 419 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 31 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2867C>A rrl_n.2867C>A 1 non_coding_transcript_exon_variant 1476524 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 558 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 80 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2868A>G rrl_n.2868A>G 1 non_coding_transcript_exon_variant 1476525 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 748 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 95 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2873C>T rrl_n.2873C>T 1 non_coding_transcript_exon_variant 1476530 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 526 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 80 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2879G>A rrl_n.2879G>A 1 non_coding_transcript_exon_variant 1476536 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 503 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 93 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.287G>C rrl_n.287G>C 1 non_coding_transcript_exon_variant 1473944 1 6 0 6 0 6 373 17433 0 0 0.0098410144176726 0.999655943574746 0.999251285574099 0.999873727224798 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 39.8653094124675 1 232 852 False False 0 0 39.8653094124675 0 0 0.0098410144176726 0.999655943574746 0.999251285574099 0.999873727224798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 137 6621 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 117.538380750032 1 16.5 516 False False 0 0 0 0 0 0 0 0 0 117.538380750032 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 NA 3) Uncertain significance No change no 1 +Linezolid rrl n.2880A>G rrl_n.2880A>G 1 non_coding_transcript_exon_variant 1476537 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 796 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 67 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2881A>G rrl_n.2881A>G 1 non_coding_transcript_exon_variant 1476538 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 692 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 78 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2882A>G rrl_n.2882A>G 1 non_coding_transcript_exon_variant 1476539 1 2 0 2 0 3 373 17436 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 249.380449704342 1 232 852 False False 0 0 113.680929631125 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 1831.45523677849 1 16.5 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 23 3) Uncertain significance No change no 1 +Linezolid rrl n.2883C>G rrl_n.2883C>G 1 non_coding_transcript_exon_variant 1476540 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 445 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 220 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 91 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2886G>A rrl_n.2886G>A 1 non_coding_transcript_exon_variant 1476543 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Linezolid rrl n.2890C>T rrl_n.2890C>T 1 non_coding_transcript_exon_variant 1476547 0 0 0 0 1 2 372 17437 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999885314524915 0.999585778685812 0.999986110755134 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 749 852 False False 23.4368279569892 0.396197405925517 449.369433886118 0 0 0.00986733780971405 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 453 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 109 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2904C>T rrl_n.2904C>T 1 non_coding_transcript_exon_variant 1476561 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 2 3) Uncertain significance No change no 1 +Linezolid rrl n.2910C>T rrl_n.2910C>T 1 non_coding_transcript_exon_variant 1476567 0 0 0 0 1 3 372 17436 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999827971787373 0.999497343686186 0.999964522241709 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 693 852 False False 15.6236559139784 0.296818208001951 195.090770439127 0 0 0.00986733780971405 0.999827971787373 0.999497343686186 0.999964522241709 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 409 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 135 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2915G>C rrl_n.2915G>C 1 non_coding_transcript_exon_variant 1476572 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 780 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 473 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2916A>C rrl_n.2916A>C 1 non_coding_transcript_exon_variant 1476573 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 634 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 49 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2916A>G rrl_n.2916A>G 1 non_coding_transcript_exon_variant 1476573 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Linezolid rrl n.2919C>T rrl_n.2919C>T 1 non_coding_transcript_exon_variant 1476576 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.2920T>G rrl_n.2920T>G 1 non_coding_transcript_exon_variant 1476577 0 0 0 0 1 3 372 17436 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999827971787373 0.999497343686186 0.999964522241709 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 446 852 False False 15.6236559139784 0.296818208001951 195.090770439127 0 0 0.00986733780971405 0.999827971787373 0.999497343686186 0.999964522241709 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 56 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2921C>A rrl_n.2921C>A 1 non_coding_transcript_exon_variant 1476578 1 2 0 2 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 249.394754138913 1 45.5 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Linezolid rrl n.2927C>T rrl_n.2927C>T 1 non_coding_transcript_exon_variant 1476584 0 0 0 0 1 3 372 17436 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999827971787373 0.999497343686186 0.999964522241709 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 750 852 False False 15.6236559139784 0.296818208001951 195.090770439127 0 0 0.00986733780971405 0.999827971787373 0.999497343686186 0.999964522241709 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 454 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 123 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2928A>G rrl_n.2928A>G 1 non_coding_transcript_exon_variant 1476585 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 733 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 441 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 30 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2937C>T rrl_n.2937C>T 1 non_coding_transcript_exon_variant 1476594 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 751 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 48 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2938C>A rrl_n.2938C>A 1 non_coding_transcript_exon_variant 1476595 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 504 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 268 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 3 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2938C>T rrl_n.2938C>T 1 non_coding_transcript_exon_variant 1476595 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 605 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Linezolid rrl n.2939C>T rrl_n.2939C>T 1 non_coding_transcript_exon_variant 1476596 1 1 0 1 0 3 373 17436 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 1772.7002684543 1 232 852 False False 0 0 113.680929631125 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 1831.45523677849 1 16.5 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 30 3) Uncertain significance No change no 1 +Linezolid rrl n.2943A>T rrl_n.2943A>T 1 non_coding_transcript_exon_variant 1476600 1 2 0 2 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 249.394754138913 1 45.5 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Linezolid rrl n.2944G>A rrl_n.2944G>A 1 non_coding_transcript_exon_variant 1476601 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 559 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 308 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 28 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2945G>T rrl_n.2945G>T 1 non_coding_transcript_exon_variant 1476602 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 590 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 335 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 3 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2946G>A rrl_n.2946G>A 1 non_coding_transcript_exon_variant 1476603 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 674 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 16 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2950C>T rrl_n.2950C>T 1 non_coding_transcript_exon_variant 1476607 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 718 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 31 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2951C>A rrl_n.2951C>A 1 non_coding_transcript_exon_variant 1476608 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 480 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 246 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 6 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2951C>G rrl_n.2951C>G 1 non_coding_transcript_exon_variant 1476608 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 759 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 15 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2951C>T rrl_n.2951C>T 1 non_coding_transcript_exon_variant 1476608 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 459 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 231 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 2 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2957A>G rrl_n.2957A>G 1 non_coding_transcript_exon_variant 1476614 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 543 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 300 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 29 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2962C>T rrl_n.2962C>T 1 non_coding_transcript_exon_variant 1476619 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 560 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 43 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2964C>A rrl_n.2964C>A 1 non_coding_transcript_exon_variant 1476621 1 3 0 3 0 3 373 17436 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 113.680929631125 1 232 852 False False 0 0 113.680929631125 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 258.403294607065 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 6 3) Uncertain significance No change no 1 +Linezolid rrl n.2964C>T rrl_n.2964C>T 1 non_coding_transcript_exon_variant 1476621 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 571 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 16 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2967T>A rrl_n.2967T>A 1 non_coding_transcript_exon_variant 1476624 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 665 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2967T>G rrl_n.2967T>G 1 non_coding_transcript_exon_variant 1476624 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 734 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 18 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2971T>A rrl_n.2971T>A 1 non_coding_transcript_exon_variant 1476628 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 404 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 35 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2973A>G rrl_n.2973A>G 1 non_coding_transcript_exon_variant 1476630 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 675 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 30 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2974G>A rrl_n.2974G>A 1 non_coding_transcript_exon_variant 1476631 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Linezolid rrl n.2980C>A rrl_n.2980C>A 1 non_coding_transcript_exon_variant 1476637 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 460 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 232 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 9 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2980C>G rrl_n.2980C>G 1 non_coding_transcript_exon_variant 1476637 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 405 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 28 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.2981C>T rrl_n.2981C>T 1 non_coding_transcript_exon_variant 1476638 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 752 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 16 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.3004A>G rrl_n.3004A>G 1 non_coding_transcript_exon_variant 1476661 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 580 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 326 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 6 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.3005_3006dupCC rrl_n.3005_3006dupCC 1 non_coding_transcript_exon_variant 1476661 1 3 0 3 0 3 373 17436 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 113.680929631125 1 232 852 False False 0 0 113.680929631125 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.3006C>T rrl_n.3006C>T 1 non_coding_transcript_exon_variant 1476663 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.3007T>G rrl_n.3007T>G 1 non_coding_transcript_exon_variant 1476664 1 1 0 1 0 9 373 17430 0 0 0.0098410144176726 0.999483915362119 0.999020537685852 0.999763986951471 0 0 0.336267116879942 0 0 0.975 0 0 0.336267116879942 0 0 1772.10717939274 1 232 852 False False 0 0 23.7503925717735 0 0 0.0098410144176726 0.999483915362119 0.999020537685852 0.999763986951471 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 9 137 6615 0 0 0.0265668510962833 0.998641304347826 0.99742234629094 0.999378535554749 0 0 0.336267116879942 0 0 0.975 0 0 0.336267116879942 0 0 1829.57486616003 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 24.7143596106325 0 0 0.0265668510962833 0.998641304347826 0.99742234629094 0.999378535554749 47 3) Uncertain significance No change no 1 +Linezolid rrl n.3008T>G rrl_n.3008T>G 1 non_coding_transcript_exon_variant 1476665 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 774 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 467 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 4 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.3009C>T rrl_n.3009C>T 1 non_coding_transcript_exon_variant 1476666 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 676 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 396 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 2 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.3012C>T rrl_n.3012C>T 1 non_coding_transcript_exon_variant 1476669 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance No change no 1 +Linezolid rrl n.3017T>C rrl_n.3017T>C 1 non_coding_transcript_exon_variant 1476674 1 5 0 5 0 5 373 17434 0 0 0.0098410144176726 0.999713286312288 0.999331033812208 0.999906898501965 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 51.1583852845118 1 45.5 852 False False 0 0 51.1583852845118 0 0 0.0098410144176726 0.999713286312288 0.999331033812208 0.999906898501965 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 3) Uncertain significance No change no 1 +Linezolid rrl n.3018C>G rrl_n.3018C>G 1 non_coding_transcript_exon_variant 1476675 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 753 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 455 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 3 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.302T>C rrl_n.302T>C 1 non_coding_transcript_exon_variant 1473959 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance No change no 1 +Linezolid rrl n.3035T>C rrl_n.3035T>C 1 non_coding_transcript_exon_variant 1476692 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 527 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 286 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 1 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.3037G>A rrl_n.3037G>A 1 non_coding_transcript_exon_variant 1476694 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 677 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 397 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.303T>C rrl_n.303T>C 1 non_coding_transcript_exon_variant 1473960 1 1 0 1 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 1772.79911553209 1 232 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.303T>G rrl_n.303T>G 1 non_coding_transcript_exon_variant 1473960 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance No change no 1 +Linezolid rrl n.3042A>T rrl_n.3042A>T 1 non_coding_transcript_exon_variant 1476699 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 432 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 209 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.3053C>T rrl_n.3053C>T 1 non_coding_transcript_exon_variant 1476710 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.3053delC rrl_n.3053delC 1 non_coding_transcript_exon_variant 1476704 1 3 0 3 0 10 373 17429 0 0 0.0098410144176726 0.999426572624577 0.998945700319482 0.999724986127498 0 0 0.30849710781876 0 0 0.707598226178713 0 0 0.30849710781876 0 0 113.634708389316 1 232 852 False False 0 0 20.9154638474844 0 0 0.0098410144176726 0.999426572624577 0.998945700319482 0.999724986127498 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 7 137 6617 0 0 0.0265668510962833 0.998943236714976 0.997823883513531 0.999575024140687 0 0 0.409616397225003 0 0 0.841886116991581 0 0 0.409616397225003 0 0 258.208209216871 1 185 516 False False 0 0 0 0 0 0 0 0 0 33.8487376789655 0 0 0.0265668510962833 0.998943236714976 0.997823883513531 0.999575024140687 11 3) Uncertain significance No change no 1 +Linezolid rrl n.3063G>A rrl_n.3063G>A 1 non_coding_transcript_exon_variant 1476720 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 650 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Linezolid rrl n.3064G>A rrl_n.3064G>A 1 non_coding_transcript_exon_variant 1476721 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance No change no 1 +Linezolid rrl n.3068C>T rrl_n.3068C>T 1 non_coding_transcript_exon_variant 1476725 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 2 3) Uncertain significance No change no 1 +Linezolid rrl n.3072A>G rrl_n.3072A>G 1 non_coding_transcript_exon_variant 1476729 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.3094A>G rrl_n.3094A>G 1 non_coding_transcript_exon_variant 1476751 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance No change no 1 +Linezolid rrl n.3099G>C rrl_n.3099G>C 1 non_coding_transcript_exon_variant 1476756 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 635 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.3104G>T rrl_n.3104G>T 1 non_coding_transcript_exon_variant 1476761 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.3136A>T rrl_n.3136A>T 1 non_coding_transcript_exon_variant 1476793 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance No change no 1 +Linezolid rrl n.3138A>G rrl_n.3138A>G 1 non_coding_transcript_exon_variant 1476795 1 2 0 2 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 249.394754138913 1 45.5 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.326A>G rrl_n.326A>G 1 non_coding_transcript_exon_variant 1473983 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.328A>G rrl_n.328A>G 1 non_coding_transcript_exon_variant 1473985 1 3 0 3 0 3 373 17436 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 113.680929631125 1 232 852 False False 0 0 113.680929631125 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.335A>C rrl_n.335A>C 1 non_coding_transcript_exon_variant 1473992 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance No change no 1 +Linezolid rrl n.344C>T rrl_n.344C>T 1 non_coding_transcript_exon_variant 1474001 1 575 17 558 19 592 354 16847 0.0509383378016085 0.0309432287785106 0.0784057705430451 0.966053099374964 0.963257781555841 0.968691553891967 0.0310965630114566 0.0188238739140407 0.0481364388550404 0.0295652173913043 0.0173151812483386 0.0469157172968439 0.0279146141215106 0.0163435672108456 0.0443186667391967 1.44988660065204 0.829016695391779 2.37622999304117 0.137271131810687 NA NA False True 1.52739444953428 0.902083408972641 2.44254998829827 0.045822102425876 0.0269163142564002 0.0723535847028576 0.966053099374964 0.963257781555841 0.968691553891967 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 216 2 214 3 225 134 6399 0.0218978102189781 0.00453882266370741 0.0626599862608879 0.966032608695652 0.961384621963124 0.970264169053165 0.0131578947368421 0.00272173754954941 0.0379692901072911 0.00925925925925925 0.0011233128484624 0.0330455397185904 0.00881057268722467 0.00106878789299772 0.0314626479841827 0.446296554610126 0.0531571684505178 1.66429374291838 0.328489477893659 NA NA False True 1 1 1 0 0 1 0 0.636716417910447 0.128691453343031 1.92575777777013 0.0147058823529411 0.00178593881328326 0.052112023364688 0.966032608695652 0.961384621963124 0.970264169053165 2054 Not assoc w R 5) Not assoc w R No change yes 1 +Linezolid rrl n.350A>C rrl_n.350A>C 1 non_coding_transcript_exon_variant 1474007 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Linezolid rrl n.354G>A rrl_n.354G>A 1 non_coding_transcript_exon_variant 1474011 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 2 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.-35G>A rrl_n.-35G>A 1 upstream_gene_variant 1473623 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 505 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.367G>T rrl_n.367G>T 1 non_coding_transcript_exon_variant 1474024 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 735 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 442 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance No change no 1 +Linezolid rrl n.-39G>A rrl_n.-39G>A 1 upstream_gene_variant 1473619 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.3G>A rrl_n.3G>A 1 non_coding_transcript_exon_variant 1473660 1 3 0 3 0 3 373 17436 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 113.680929631125 1 232 852 False False 0 0 113.680929631125 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 1 3) Uncertain significance No change no 1 +Linezolid rrl n.408C>T rrl_n.408C>T 1 non_coding_transcript_exon_variant 1474065 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance No change no 1 +Linezolid rrl n.417C>T rrl_n.417C>T 1 non_coding_transcript_exon_variant 1474074 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.-41T>C rrl_n.-41T>C 1 upstream_gene_variant 1473617 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.424C>T rrl_n.424C>T 1 non_coding_transcript_exon_variant 1474081 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 818 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Linezolid rrl n.435G>T rrl_n.435G>T 1 non_coding_transcript_exon_variant 1474092 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.-43G>C rrl_n.-43G>C 1 upstream_gene_variant 1473615 1 3 0 3 0 5 373 17434 0 0 0.0098410144176726 0.999713286312288 0.999331033812208 0.999906898501965 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 113.667723477788 1 232 852 False False 0 0 51.1583852845118 0 0 0.0098410144176726 0.999713286312288 0.999331033812208 0.999906898501965 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 137 6620 0 0 0.0265668510962833 0.9993961352657 0.998454594750107 0.999835443455214 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 117.520679860744 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 73.7000674034286 0 0 0.0265668510962833 0.9993961352657 0.998454594750107 0.999835443455214 3 3) Uncertain significance No change no 1 +Linezolid rrl n.447G>A rrl_n.447G>A 1 non_coding_transcript_exon_variant 1474104 1 2 0 2 0 3 373 17436 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 249.380449704342 1 232 852 False False 0 0 113.680929631125 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 1831.45523677849 1 16.5 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 4 3) Uncertain significance No change no 1 +Linezolid rrl n.448T>C rrl_n.448T>C 1 non_coding_transcript_exon_variant 1474105 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Linezolid rrl n.450T>C rrl_n.450T>C 1 non_coding_transcript_exon_variant 1474107 1 5 0 5 0 5 373 17434 0 0 0.0098410144176726 0.999713286312288 0.999331033812208 0.999906898501965 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 51.1583852845118 1 45.5 852 False False 0 0 51.1583852845118 0 0 0.0098410144176726 0.999713286312288 0.999331033812208 0.999906898501965 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.453delA rrl_n.453delA 1 non_coding_transcript_exon_variant 1474108 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 544 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.46C>G rrl_n.46C>G 1 non_coding_transcript_exon_variant 1473703 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Linezolid rrl n.471G>T rrl_n.471G>T 1 non_coding_transcript_exon_variant 1474128 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.475G>T rrl_n.475G>T 1 non_coding_transcript_exon_variant 1474132 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.478G>A rrl_n.478G>A 1 non_coding_transcript_exon_variant 1474135 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 760 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 459 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 2 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.483C>T rrl_n.483C>T 1 non_coding_transcript_exon_variant 1474140 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 678 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 398 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 18 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.494C>T rrl_n.494C>T 1 non_coding_transcript_exon_variant 1474151 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 420 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 201 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 27 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.496C>G rrl_n.496C>G 1 non_coding_transcript_exon_variant 1474153 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 433 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 210 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 7 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.-49G>C rrl_n.-49G>C 1 upstream_gene_variant 1473609 1 16 0 16 0 16 373 17423 0 0 0.0098410144176726 0.999082516199323 0.998510490256918 0.999475490673985 0 0 0.205907214207822 0 0 0.205907214207822 0 0 0.205907214207822 0 0 12.1609224191709 1 232 852 False False 0 0 12.1609224191709 0 0 0.0098410144176726 0.999082516199323 0.998510490256918 0.999475490673985 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 0 9 137 6615 0 0 0.0265668510962833 0.998641304347826 0.99742234629094 0.999378535554749 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.336267116879942 0 0 24.7143596106325 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 24.7143596106325 0 0 0.0265668510962833 0.998641304347826 0.99742234629094 0.999378535554749 21 3) Uncertain significance No change no 1 +Linezolid rrl n.-4G>C rrl_n.-4G>C 1 upstream_gene_variant 1473654 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance No change no 1 +Linezolid rrl n.509G>C rrl_n.509G>C 1 non_coding_transcript_exon_variant 1474166 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 581 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 327 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 6 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.517A>G rrl_n.517A>G 1 non_coding_transcript_exon_variant 1474174 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 517 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 278 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 6 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.522C>T rrl_n.522C>T 1 non_coding_transcript_exon_variant 1474179 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 819 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 501 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 6 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.526T>C rrl_n.526T>C 1 non_coding_transcript_exon_variant 1474183 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 651 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 380 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 25 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.527C>T rrl_n.527C>T 1 non_coding_transcript_exon_variant 1474184 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 494 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 260 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 43 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.529A>G rrl_n.529A>G 1 non_coding_transcript_exon_variant 1474186 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 572 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 318 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 15 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.533C>T rrl_n.533C>T 1 non_coding_transcript_exon_variant 1474190 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.535G>T rrl_n.535G>T 1 non_coding_transcript_exon_variant 1474192 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Linezolid rrl n.544T>C rrl_n.544T>C 1 non_coding_transcript_exon_variant 1474201 1 6 0 6 0 7 373 17432 0 0 0.0098410144176726 0.999598600837204 0.99917314031148 0.999838601975561 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 39.8629714341046 1 232 852 False False 0 0 32.5355852264781 0 0 0.0098410144176726 0.999598600837204 0.99917314031148 0.999838601975561 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 7 137 6617 0 0 0.0265668510962833 0.998943236714976 0.997823883513531 0.999575024140687 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 41.3671292938094 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 33.8487376789655 0 0 0.0265668510962833 0.998943236714976 0.997823883513531 0.999575024140687 27 3) Uncertain significance No change no 1 +Linezolid rrl n.545delT rrl_n.545delT 1 non_coding_transcript_exon_variant 1474200 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 421 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 202 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 7 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.552G>A rrl_n.552G>A 1 non_coding_transcript_exon_variant 1474209 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.561T>A rrl_n.561T>A 1 non_coding_transcript_exon_variant 1474218 0 0 0 0 1 6 372 17433 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999655943574746 0.999251285574099 0.999873727224798 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA 0 0 0.4592581264399 NA NA NA NA 736 852 False False 7.81048387096774 0.169351813995106 64.6351898930483 0 0 0.00986733780971405 0.999655943574746 0.999251285574099 0.999873727224798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 137 6619 0 0 0.0265668510962833 0.999245169082125 0.998239362946804 0.999754864475697 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 443 516 False False 0 0 0 0 0 0 0 0 0 53.1553319379921 0 0 0.0265668510962833 0.999245169082125 0.998239362946804 0.999754864475697 143 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.571T>A rrl_n.571T>A 1 non_coding_transcript_exon_variant 1474228 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 797 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 485 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 14 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.571T>C rrl_n.571T>C 1 non_coding_transcript_exon_variant 1474228 0 0 0 0 1 2 372 17437 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999885314524915 0.999585778685812 0.999986110755134 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 406 852 False False 23.4368279569892 0.396197405925517 449.369433886118 0 0 0.00986733780971405 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 192 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 94 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.575C>T rrl_n.575C>T 1 non_coding_transcript_exon_variant 1474232 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.579G>A rrl_n.579G>A 1 non_coding_transcript_exon_variant 1474236 0 0 0 0 1 2 372 17437 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999885314524915 0.999585778685812 0.999986110755134 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 561 852 False False 23.4368279569892 0.396197405925517 449.369433886118 0 0 0.00986733780971405 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 309 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 47 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.592G>T rrl_n.592G>T 1 non_coding_transcript_exon_variant 1474249 1 0 0 0 0 5 373 17434 0 0 0.0098410144176726 0.999713286312288 0.999331033812208 0.999906898501965 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 719 852 False False 0 0 51.1583852845118 0 0 0.0098410144176726 0.999713286312288 0.999331033812208 0.999906898501965 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 137 6619 0 0 0.0265668510962833 0.999245169082125 0.998239362946804 0.999754864475697 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 429 516 False False 0 0 0 0 0 0 0 0 0 53.1553319379921 0 0 0.0265668510962833 0.999245169082125 0.998239362946804 0.999754864475697 160 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.595T>A rrl_n.595T>A 1 non_coding_transcript_exon_variant 1474252 0 0 0 0 1 3 372 17436 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999827971787373 0.999497343686186 0.999964522241709 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 704 852 False False 15.6236559139784 0.296818208001951 195.090770439127 0 0 0.00986733780971405 0.999827971787373 0.999497343686186 0.999964522241709 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 417 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 125 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.596A>T rrl_n.596A>T 1 non_coding_transcript_exon_variant 1474253 0 0 0 0 1 1 372 17438 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999942657262457 0.999680548589877 0.999998548208635 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 761 852 False False 46.8763440860215 0.595582156681904 3550.80494241025 0 0 0.00986733780971405 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 42 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.598delC rrl_n.598delC 1 non_coding_transcript_exon_variant 1474253 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 481 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.609T>C rrl_n.609T>C 1 non_coding_transcript_exon_variant 1474266 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 434 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 211 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 4 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.60G>A rrl_n.60G>A 1 non_coding_transcript_exon_variant 1473717 1 1 0 1 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 1772.79911553209 1 232 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 502 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 2 3) Uncertain significance No change no 1 +Linezolid rrl n.612C>T rrl_n.612C>T 1 non_coding_transcript_exon_variant 1474269 1 3 0 3 0 4 373 17435 0 0 0.0098410144176726 0.99977062904983 0.999412824358174 0.99993750071294 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 113.674326546033 1 232 852 False False 0 0 70.9839175273221 0 0 0.0098410144176726 0.99977062904983 0.999412824358174 0.99993750071294 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 494 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 55 3) Uncertain significance No change no 1 +Linezolid rrl n.627G>T rrl_n.627G>T 1 non_coding_transcript_exon_variant 1474284 1 2 0 2 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 249.394754138913 1 45.5 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 258.403294607065 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 5 3) Uncertain significance No change no 1 +Linezolid rrl n.637C>G rrl_n.637C>G 1 non_coding_transcript_exon_variant 1474294 1 71 1 70 1 92 372 17347 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.994724468146109 0.993533895898738 0.995745120524718 0.010752688172043 0.000272197442007138 0.0584581645143803 0.0140845070422535 0.000356525274603389 0.0759934161211035 0.010752688172043 0.000272197442007138 0.0584581645143803 0.666167434715821 0.0165872543275842 3.85844399152106 1 232 852 False False 0.506866526414212 0.0126655722584759 2.91290042638124 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.994724468146109 0.993533895898738 0.995745120524718 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 8 137 6616 0 0 0.0265668510962833 0.998792270531401 0.997621685806941 0.999478448499522 0 0 0.369416647552819 0 0 0.521823750104981 0 0 0.369416647552819 0 0 53.1311370563072 1 16.5 516 False False 0 0 0 0 0 0 0 0 0 28.574210735743 0 0 0.0265668510962833 0.998792270531401 0.997621685806941 0.999478448499522 246 3) Uncertain significance No change no 1 +Linezolid rrl n.637C>T rrl_n.637C>T 1 non_coding_transcript_exon_variant 1474294 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.643C>A rrl_n.643C>A 1 non_coding_transcript_exon_variant 1474300 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.650G>A rrl_n.650G>A 1 non_coding_transcript_exon_variant 1474307 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.651G>T rrl_n.651G>T 1 non_coding_transcript_exon_variant 1474308 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.669T>A rrl_n.669T>A 1 non_coding_transcript_exon_variant 1474326 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 636 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 370 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 3 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.673A>T rrl_n.673A>T 1 non_coding_transcript_exon_variant 1474330 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 809 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 24 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.686C>T rrl_n.686C>T 1 non_coding_transcript_exon_variant 1474343 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.691C>T rrl_n.691C>T 1 non_coding_transcript_exon_variant 1474348 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 461 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 233 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 38 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.694G>T rrl_n.694G>T 1 non_coding_transcript_exon_variant 1474351 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 820 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 503 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 38 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.696A>G rrl_n.696A>G 1 non_coding_transcript_exon_variant 1474353 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 545 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 301 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 20 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.698A>G rrl_n.698A>G 1 non_coding_transcript_exon_variant 1474355 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 720 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 430 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 9 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.700G>A rrl_n.700G>A 1 non_coding_transcript_exon_variant 1474357 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 582 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.702C>G rrl_n.702C>G 1 non_coding_transcript_exon_variant 1474359 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 495 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 261 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 9 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.705A>G rrl_n.705A>G 1 non_coding_transcript_exon_variant 1474362 1 0 0 0 0 3 373 17436 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 652 852 False False 0 0 113.680929631125 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 137 6621 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 381 516 False False 0 0 0 0 0 0 0 0 0 117.538380750032 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 54 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.716G>T rrl_n.716G>T 1 non_coding_transcript_exon_variant 1474373 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.718dupG rrl_n.718dupG 1 non_coding_transcript_exon_variant 1474374 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 679 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 399 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.718G>A rrl_n.718G>A 1 non_coding_transcript_exon_variant 1474375 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.723G>A rrl_n.723G>A 1 non_coding_transcript_exon_variant 1474380 1 4 1 3 1 3 372 17436 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999827971787373 0.999497343686186 0.999964522241709 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 15.6236559139784 0.296818208001951 195.090770439127 0.0811757782199132 14 852 False False 15.6236559139784 0.296818208001951 195.090770439127 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999827971787373 0.999497343686186 0.999964522241709 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.730C>T rrl_n.730C>T 1 non_coding_transcript_exon_variant 1474387 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 821 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 504 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 66 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.733C>T rrl_n.733C>T 1 non_coding_transcript_exon_variant 1474390 1 2 0 2 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 249.394754138913 1 45.5 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance No change no 1 +Linezolid rrl n.745T>C rrl_n.745T>C 1 non_coding_transcript_exon_variant 1474402 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 482 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 247 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 12 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.74T>A rrl_n.74T>A 1 non_coding_transcript_exon_variant 1473731 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 623 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 360 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 9 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.757C>G rrl_n.757C>G 1 non_coding_transcript_exon_variant 1474414 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.758C>T rrl_n.758C>T 1 non_coding_transcript_exon_variant 1474415 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance No change no 1 +Linezolid rrl n.781_782insT rrl_n.781_782insT 1 non_coding_transcript_exon_variant 1474438 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 781 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.781A>G rrl_n.781A>G 1 non_coding_transcript_exon_variant 1474438 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 583 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 328 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 4 3) Uncertain significance No change no 1 +Linezolid rrl n.782dupA rrl_n.782dupA 1 non_coding_transcript_exon_variant 1474437 1 3 0 3 0 3 373 17436 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 113.680929631125 1 232 852 False False 0 0 113.680929631125 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 137 6621 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 117.538380750032 1 16.5 516 False False 0 0 0 0 0 0 0 0 0 117.538380750032 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 NA 3) Uncertain significance No change no 1 +Linezolid rrl n.784A>G rrl_n.784A>G 1 non_coding_transcript_exon_variant 1474441 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 5 3) Uncertain significance No change no 1 +Linezolid rrl n.787G>A rrl_n.787G>A 1 non_coding_transcript_exon_variant 1474444 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 1 3) Uncertain significance No change no 1 +Linezolid rrl n.789C>T rrl_n.789C>T 1 non_coding_transcript_exon_variant 1474446 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 1 3) Uncertain significance No change no 1 +Linezolid rrl n.793T>A rrl_n.793T>A 1 non_coding_transcript_exon_variant 1474450 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 721 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 431 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 11 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.795C>T rrl_n.795C>T 1 non_coding_transcript_exon_variant 1474452 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 3 3) Uncertain significance No change no 1 +Linezolid rrl n.797G>A rrl_n.797G>A 1 non_coding_transcript_exon_variant 1474454 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 653 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 382 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 17 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.798G>A rrl_n.798G>A 1 non_coding_transcript_exon_variant 1474455 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.806G>A rrl_n.806G>A 1 non_coding_transcript_exon_variant 1474463 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.807C>T rrl_n.807C>T 1 non_coding_transcript_exon_variant 1474464 1 17 0 17 0 17 373 17422 0 0 0.0098410144176726 0.999025173461781 0.998439665579061 0.999432028313824 0 0 0.195064322969093 0 0 0.195064322969093 0 0 0.195064322969093 0 0 11.3647229722871 1 232 852 False False 0 0 11.3647229722871 0 0 0.0098410144176726 0.999025173461781 0.998439665579061 0.999432028313824 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.809G>A rrl_n.809G>A 1 non_coding_transcript_exon_variant 1474466 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 16 3) Uncertain significance No change no 1 +Linezolid rrl n.811G>A rrl_n.811G>A 1 non_coding_transcript_exon_variant 1474468 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 705 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.825G>T rrl_n.825G>T 1 non_coding_transcript_exon_variant 1474482 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 810 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.831G>T rrl_n.831G>T 1 non_coding_transcript_exon_variant 1474488 1 0 0 0 0 3 373 17436 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 562 852 False False 0 0 113.680929631125 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 137 6621 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 310 516 False False 0 0 0 0 0 0 0 0 0 117.538380750032 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 44 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.837C>T rrl_n.837C>T 1 non_coding_transcript_exon_variant 1474494 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 666 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.838G>T rrl_n.838G>T 1 non_coding_transcript_exon_variant 1474495 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 694 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.839C>A rrl_n.839C>A 1 non_coding_transcript_exon_variant 1474496 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 462 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 234 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 24 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.840G>A rrl_n.840G>A 1 non_coding_transcript_exon_variant 1474497 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 680 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.840G>C rrl_n.840G>C 1 non_coding_transcript_exon_variant 1474497 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 737 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 444 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 31 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.840G>T rrl_n.840G>T 1 non_coding_transcript_exon_variant 1474497 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Linezolid rrl n.842G>A rrl_n.842G>A 1 non_coding_transcript_exon_variant 1474499 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Linezolid rrl n.846G>C rrl_n.846G>C 1 non_coding_transcript_exon_variant 1474503 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 654 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.848C>G rrl_n.848C>G 1 non_coding_transcript_exon_variant 1474505 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 722 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 432 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 6 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.849C>G rrl_n.849C>G 1 non_coding_transcript_exon_variant 1474506 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 606 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 347 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 32 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.849C>T rrl_n.849C>T 1 non_coding_transcript_exon_variant 1474506 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 435 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.850G>T rrl_n.850G>T 1 non_coding_transcript_exon_variant 1474507 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 436 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 212 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 32 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.851C>A rrl_n.851C>A 1 non_coding_transcript_exon_variant 1474508 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 822 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.851C>T rrl_n.851C>T 1 non_coding_transcript_exon_variant 1474508 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 463 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 235 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 6 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.852G>A rrl_n.852G>A 1 non_coding_transcript_exon_variant 1474509 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 637 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.859C>A rrl_n.859C>A 1 non_coding_transcript_exon_variant 1474516 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 483 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 248 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 44 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.866C>T rrl_n.866C>T 1 non_coding_transcript_exon_variant 1474523 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance No change no 1 +Linezolid rrl n.868A>G rrl_n.868A>G 1 non_coding_transcript_exon_variant 1474525 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.870T>G rrl_n.870T>G 1 non_coding_transcript_exon_variant 1474527 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 681 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.871T>C rrl_n.871T>C 1 non_coding_transcript_exon_variant 1474528 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 464 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.873G>C rrl_n.873G>C 1 non_coding_transcript_exon_variant 1474530 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 811 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.880G>A rrl_n.880G>A 1 non_coding_transcript_exon_variant 1474537 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 762 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 460 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 54 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.882C>G rrl_n.882C>G 1 non_coding_transcript_exon_variant 1474539 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 823 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.885A>C rrl_n.885A>C 1 non_coding_transcript_exon_variant 1474542 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 638 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.894G>C rrl_n.894G>C 1 non_coding_transcript_exon_variant 1474551 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 624 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 361 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 6 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.895C>G rrl_n.895C>G 1 non_coding_transcript_exon_variant 1474552 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 447 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.896T>C rrl_n.896T>C 1 non_coding_transcript_exon_variant 1474553 1 3 0 3 0 3 373 17436 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 113.680929631125 1 232 852 False False 0 0 113.680929631125 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 137 6621 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 117.538380750032 1 16.5 516 False False 0 0 0 0 0 0 0 0 0 117.538380750032 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 2 3) Uncertain significance No change no 1 +Linezolid rrl n.901G>T rrl_n.901G>T 1 non_coding_transcript_exon_variant 1474558 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 738 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 445 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 5 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.903A>G rrl_n.903A>G 1 non_coding_transcript_exon_variant 1474560 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Linezolid rrl n.906G>A rrl_n.906G>A 1 non_coding_transcript_exon_variant 1474563 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 1 3) Uncertain significance No change no 1 +Linezolid rrl n.913G>T rrl_n.913G>T 1 non_coding_transcript_exon_variant 1474570 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 448 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.914G>A rrl_n.914G>A 1 non_coding_transcript_exon_variant 1474571 1 7 0 7 0 7 373 17432 0 0 0.0098410144176726 0.999598600837204 0.99917314031148 0.999838601975561 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 32.5355852264781 1 232 852 False False 0 0 32.5355852264781 0 0 0.0098410144176726 0.999598600837204 0.99917314031148 0.999838601975561 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 137 6621 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 117.538380750032 1 16.5 516 False False 0 0 0 0 0 0 0 0 0 117.538380750032 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 18 3) Uncertain significance No change no 1 +Linezolid rrl n.921A>G rrl_n.921A>G 1 non_coding_transcript_exon_variant 1474578 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 798 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 10 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.924C>G rrl_n.924C>G 1 non_coding_transcript_exon_variant 1474581 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 625 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 362 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance No change no 1 +Linezolid rrl n.925T>C rrl_n.925T>C 1 non_coding_transcript_exon_variant 1474582 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 754 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.926C>T rrl_n.926C>T 1 non_coding_transcript_exon_variant 1474583 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 422 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 21 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.927C>G rrl_n.927C>G 1 non_coding_transcript_exon_variant 1474584 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 465 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 24 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.929T>A rrl_n.929T>A 1 non_coding_transcript_exon_variant 1474586 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 763 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 18 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.929T>C rrl_n.929T>C 1 non_coding_transcript_exon_variant 1474586 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance No change no 1 +Linezolid rrl n.944C>T rrl_n.944C>T 1 non_coding_transcript_exon_variant 1474601 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 407 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.947G>A rrl_n.947G>A 1 non_coding_transcript_exon_variant 1474604 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance No change no 1 +Linezolid rrl n.960G>A rrl_n.960G>A 1 non_coding_transcript_exon_variant 1474617 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 799 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.969T>C rrl_n.969T>C 1 non_coding_transcript_exon_variant 1474626 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 591 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 336 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 15 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.970G>A rrl_n.970G>A 1 non_coding_transcript_exon_variant 1474627 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 607 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 348 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 14 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.975G>T rrl_n.975G>T 1 non_coding_transcript_exon_variant 1474632 1 0 0 0 0 3 373 17436 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 782 852 False False 0 0 113.680929631125 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 137 6621 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 474 516 False False 0 0 0 0 0 0 0 0 0 117.538380750032 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 38 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.979A>C rrl_n.979A>C 1 non_coding_transcript_exon_variant 1474636 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 667 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 391 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 11 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.980C>G rrl_n.980C>G 1 non_coding_transcript_exon_variant 1474637 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 800 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 486 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 3 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.981C>G rrl_n.981C>G 1 non_coding_transcript_exon_variant 1474638 1 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 783 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 475 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 32 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.982G>A rrl_n.982G>A 1 non_coding_transcript_exon_variant 1474639 1 23 0 23 0 24 373 17415 0 0 0.0098410144176726 0.998623774298985 0.997952972824365 0.999118033412474 0 0 0.142473597722525 0 0 0.148185128915224 0 0 0.142473597722525 0 0 8.15710555148088 1 232 852 False False 0 0 7.7909228162367 0 0 0.0098410144176726 0.998623774298985 0.997952972824365 0.999118033412474 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 14 0 14 0 14 137 6610 0 0 0.0265668510962833 0.997886473429951 0.996456401701132 0.998844048691853 0 0 0.231635761650116 0 0 0.231635761650116 0 0 0.231635761650116 0 0 14.7104798452186 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 14.7104798452186 0 0 0.0265668510962833 0.997886473429951 0.996456401701132 0.998844048691853 408 3) Uncertain significance No change no 1 +Linezolid rrl n.982G>C rrl_n.982G>C 1 non_coding_transcript_exon_variant 1474639 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 466 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 236 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 32 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.986A>G rrl_n.986A>G 1 non_coding_transcript_exon_variant 1474643 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 573 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 319 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 3 3) Uncertain significance New Uncertain no 0 +Linezolid rrl n.99G>T rrl_n.99G>T 1 non_coding_transcript_exon_variant 1473756 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 764 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 461 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 5 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR c.108G>A tsnR_c.108G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 249.394754138913 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 258.403294607065 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid tsnR c.108G>T tsnR_c.108G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 10 373 17429 0 0 0.0098410144176726 0.999426572624577 0.998945700319482 0.999724986127498 0 0 0.30849710781876 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.9154638474844 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 10 137 6614 0 0 0.0265668510962833 0.998490338164251 0.997225436330416 0.999275828568208 0 0 0.30849710781876 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 21.7720387329624 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid tsnR c.111G>C tsnR_c.111G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1772.89796229585 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1831.72385186727 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid tsnR c.-13C>T tsnR_c.-13C>T 2 upstream_gene_variant 1853593 1 2 0 2 0 3 373 17436 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 249.380449704342 1 232 852 False False 0 0 113.680929631125 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 1 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR c.144C>T tsnR_c.144C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1772.89796229585 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid tsnR c.147C>G tsnR_c.147C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1772.89796229585 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid tsnR c.186C>T tsnR_c.186C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1772.89796229585 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1831.72385186727 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid tsnR c.189G>T tsnR_c.189G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 373 17435 0 0 0.0098410144176726 0.99977062904983 0.999412824358174 0.99993750071294 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.9839175273221 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1831.72385186727 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid tsnR c.18G>C tsnR_c.18G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1772.89796229585 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1831.72385186727 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid tsnR c.195G>A tsnR_c.195G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1772.89796229585 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1831.72385186727 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid tsnR c.21C>A tsnR_c.21C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1772.89796229585 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1831.72385186727 NA NA NA NA NA NA 15 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid tsnR c.-23C>T tsnR_c.-23C>T 2 upstream_gene_variant 1853583 1 4 0 4 0 4 373 17435 0 0 0.0098410144176726 0.99977062904983 0.999412824358174 0.99993750071294 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 70.9839175273221 1 232 852 False False 0 0 70.9839175273221 0 0 0.0098410144176726 0.99977062904983 0.999412824358174 0.99993750071294 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR c.240T>C tsnR_c.240T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1772.89796229585 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1831.72385186727 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid tsnR c.24G>A tsnR_c.24G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 24 373 17415 0 0 0.0098410144176726 0.998623774298985 0.997952972824365 0.999118033412474 0 0 0.142473597722525 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.7909228162367 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 14 137 6610 0 0 0.0265668510962833 0.997886473429951 0.996456401701132 0.998844048691853 0 0 0.231635761650116 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 14.7104798452186 NA NA NA NA NA NA 118 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid tsnR c.-28G>C tsnR_c.-28G>C 2 upstream_gene_variant 1853578 1 1 0 1 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 1772.79911553209 1 232 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 1 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR c.-29G>A tsnR_c.-29G>A 2 upstream_gene_variant 1853577 1 5 0 5 0 7 373 17432 0 0 0.0098410144176726 0.999598600837204 0.99917314031148 0.999838601975561 0 0 0.409616397225003 0 0 0.521823750104981 0 0 0.409616397225003 0 0 51.1525047816642 1 232 852 False False 0 0 32.5355852264781 0 0 0.0098410144176726 0.999598600837204 0.99917314031148 0.999838601975561 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 137 6621 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 117.538380750032 1 16.5 516 False False 0 0 0 0 0 0 0 0 0 117.538380750032 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 12 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR c.-29G>T tsnR_c.-29G>T 2 upstream_gene_variant 1853577 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR c.-2C>T tsnR_c.-2C>T 2 upstream_gene_variant 1853604 1 2 0 2 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 249.394754138913 1 45.5 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR c.312C>T tsnR_c.312C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1772.89796229585 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid tsnR c.321T>G tsnR_c.321T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 249.394754138913 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 258.403294607065 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid tsnR c.330C>T tsnR_c.330C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 249.394754138913 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 258.403294607065 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid tsnR c.333G>A tsnR_c.333G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1772.89796229585 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid tsnR c.369C>T tsnR_c.369C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 13 1178 360 16261 0.03485254691689 0.0186855897997786 0.058861561967005 0.932450255175182 0.928624061303465 0.936131455528795 0.0109151973131822 0.00582432609990103 0.0185929938546 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.498474344463308 0.262020686802518 0.866886109764302 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 3 729 134 5895 0.0218978102189781 0.00453882266370741 0.0626599862608879 0.889945652173913 0.88216127271702 0.897384834800868 0.0040983606557377 0.000845979260627627 0.0119300473291507 NA NA NA NA NA NA NA NA NA NA NA NA False True 1 1 1 0 0 0 0 0.181039248203427 0.0368042123423779 0.542963112189211 NA NA NA NA NA NA 3393 5) Not assoc w R Now listed Silent mutation no 0 +Linezolid tsnR c.378C>A tsnR_c.378C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1772.89796229585 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1831.72385186727 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid tsnR c.-37C>T tsnR_c.-37C>T 2 upstream_gene_variant 1853569 1 4 0 4 0 4 373 17435 0 0 0.0098410144176726 0.99977062904983 0.999412824358174 0.99993750071294 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 70.9839175273221 1 232 852 False False 0 0 70.9839175273221 0 0 0.0098410144176726 0.99977062904983 0.999412824358174 0.99993750071294 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 18 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR c.-3C>T tsnR_c.-3C>T 2 upstream_gene_variant 1853603 1 7 0 7 0 7 373 17432 0 0 0.0098410144176726 0.999598600837204 0.99917314031148 0.999838601975561 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 32.5355852264781 1 232 852 False False 0 0 32.5355852264781 0 0 0.0098410144176726 0.999598600837204 0.99917314031148 0.999838601975561 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR c.-41G>A tsnR_c.-41G>A 2 upstream_gene_variant 1853565 1 1 0 1 0 4 373 17435 0 0 0.0098410144176726 0.99977062904983 0.999412824358174 0.99993750071294 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 1772.60142106247 1 394.5 852 False False 0 0 70.9839175273221 0 0 0.0098410144176726 0.99977062904983 0.999412824358174 0.99993750071294 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 74 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR c.465C>T tsnR_c.465C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 373 17434 0 0 0.0098410144176726 0.999713286312288 0.999331033812208 0.999906898501965 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 51.1583852845118 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 258.403294607065 NA NA NA NA NA NA 38 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid tsnR c.468C>A tsnR_c.468C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1772.89796229585 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1831.72385186727 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid tsnR c.-46G>A tsnR_c.-46G>A 2 upstream_gene_variant 1853560 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR c.-48C>T tsnR_c.-48C>T 2 upstream_gene_variant 1853558 NA 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 849 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR c.504C>T tsnR_c.504C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1772.89796229585 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1831.72385186727 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid tsnR c.516C>T tsnR_c.516C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1772.89796229585 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1831.72385186727 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid tsnR c.544C>T tsnR_c.544C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1772.89796229585 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid tsnR c.564A>C tsnR_c.564A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 7 161 366 17278 0.0187667560321715 0.00757768035838521 0.0382828593803756 0.990767819255691 0.989234792110244 0.992133642512462 0.0416666666666666 0.0169137685293725 0.0839625048108698 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.05250653361843 0.806434440066903 4.36970608306631 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 19 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid tsnR c.588C>T tsnR_c.588C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1772.89796229585 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid tsnR c.601C>T tsnR_c.601C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1772.89796229585 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid tsnR c.625C>T tsnR_c.625C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 15 372 17424 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999139858936865 0.998581724314111 0.999518508191326 0.0625 0.00158111172276588 0.302320738434531 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.12258064516129 0.0739780467558199 20.3962908659609 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid tsnR c.633G>A tsnR_c.633G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1772.89796229585 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid tsnR c.636C>G tsnR_c.636C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 14 373 17425 0 0 0.0098410144176726 0.999197201674408 0.998653407304194 0.999561035390213 0 0 0.231635761650116 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 14.1403168132603 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 8 137 6616 0 0 0.0265668510962833 0.998792270531401 0.997621685806941 0.999478448499522 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 28.574210735743 NA NA NA NA NA NA 46 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid tsnR c.649T>C tsnR_c.649T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1772.89796229585 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid tsnR c.669C>T tsnR_c.669C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 7 373 17432 0 0 0.0098410144176726 0.999598600837204 0.99917314031148 0.999838601975561 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 32.5355852264781 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 137 6620 0 0 0.0265668510962833 0.9993961352657 0.998454594750107 0.999835443455214 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 73.7000674034286 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid tsnR c.681C>T tsnR_c.681C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 372 17438 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 0.999942657262457 0.999680548589877 0.999998548208635 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 46.8763440860215 0.595582156681904 3550.80494241025 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid tsnR c.687A>G tsnR_c.687A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1772.89796229585 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid tsnR c.69G>A tsnR_c.69G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 40 373 17399 0 0 0.0098410144176726 0.997706290498308 0.996877914714527 0.998360850195232 0 0 0.0880973028788023 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.52801062165868 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 9 137 6615 0 0 0.0265668510962833 0.998641304347826 0.99742234629094 0.999378535554749 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 24.7143596106325 NA NA NA NA NA NA 105 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid tsnR c.-6A>G tsnR_c.-6A>G 2 upstream_gene_variant 1853600 1 2 0 2 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 249.394754138913 1 45.5 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 258.403294607065 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 NA 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR c.705A>C tsnR_c.705A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1772.89796229585 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid tsnR c.748C>T tsnR_c.748C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1772.89796229585 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1831.72385186727 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid tsnR c.762T>C tsnR_c.762T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 372 17439 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 1 0.999788491924625 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.19880183801736 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid tsnR c.9C>T tsnR_c.9C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1772.89796229585 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Linezolid tsnR c.-9G>C tsnR_c.-9G>C 2 upstream_gene_variant 1853597 1 59 0 59 0 72 373 17367 0 0 0.0098410144176726 0.995871322896955 0.994803399776215 0.996768204377748 0 0 0.0499440837058546 0 0 0.0606089009503398 0 0 0.0499440837058546 0 0 3.01854925036307 0.637556991091426 18 852 False False 0 0 2.45972314196779 0 0 0.0098410144176726 0.995871322896955 0.994803399776215 0.996768204377748 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 16 0 16 0 18 137 6606 0 0 0.0265668510962833 0.997282608695652 0.99570873746243 0.998388731142238 0 0 0.185301968137852 0 0 0.205907214207822 0 0 0.185301968137852 0 0 12.6474123831737 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 11.0955587581926 0 0 0.0265668510962833 0.997282608695652 0.99570873746243 0.998388731142238 142 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR LoF tsnR_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 15 1 14 5 15 368 17424 0.0134048257372654 0.00436645369297377 0.0310035844605445 0.999139858936865 0.998581724314111 0.999518508191326 0.25 0.0865714691014345 0.491045871707957 0.0666666666666666 0.0016864302413527 0.319484566578303 0.0625 0.00158111172276588 0.302320738434531 3.38198757763975 0.0797695339236321 22.3246007782038 0.269644169738849 16 852 False False 15.7826086956521 4.46074599103992 45.9678700421516 0.002710027100271 6.86095920111649e-05 0.0150061011329357 0.999139858936865 0.998581724314111 0.999518508191326 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 12 0 12 2 13 135 6611 0.0145985401459854 0.00177286642699366 0.0517388975821079 0.998037439613526 0.996646300229615 0.9989546183935 0.133333333333333 0.0165759134400836 0.404602696603372 0 0 0.264648469397051 0 0 0.24705263800047 0 0 17.8243819348223 1 16.5 516 False False 0 0 0 0 0 0 0 7.53390313390313 0.816992448080179 33.7189423858776 0 0 0.0269550815831828 0.998037439613526 0.996646300229615 0.9989546183935 NA 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Ala122Glu tsnR_p.Ala122Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 837 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Ala140Thr tsnR_p.Ala140Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Ala140Val tsnR_p.Ala140Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 845 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Ala172fs tsnR_p.Ala172fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Ala172Thr tsnR_p.Ala172Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 249.394754138913 1 45.5 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Ala186fs tsnR_p.Ala186fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Ala188Thr tsnR_p.Ala188Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 840 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 513 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Ala219Gly tsnR_p.Ala219Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Ala223Val tsnR_p.Ala223Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Ala237Val tsnR_p.Ala237Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Ala247Thr tsnR_p.Ala247Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Ala24Val tsnR_p.Ala24Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 30 0 30 0 31 373 17408 0 0 0.0098410144176726 0.998222375136189 0.997477744175293 0.998791880469105 0 0 0.11218874692237 0 0 0.115703308222027 0 0 0.11218874692237 0 0 6.1342493572018 1 232 852 False False 0 0 5.92425316415694 0 0 0.0098410144176726 0.998222375136189 0.997477744175293 0.998791880469105 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 35 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Ala254Val tsnR_p.Ala254Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Ala256Val tsnR_p.Ala256Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 249.394754138913 1 45.5 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 3 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Ala29Thr tsnR_p.Ala29Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 841 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Ala40Val tsnR_p.Ala40Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 372 17439 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 1 0.999788491924625 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 1.19880183801736 Inf 0.0209409386930159 8.5 852 False False Inf 1.19880183801736 Inf 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 1 0.999788491924625 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Ala53Thr tsnR_p.Ala53Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 249.394754138913 1 45.5 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 137 6622 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 258.403294607065 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 258.403294607065 0 0 0.0265668510962833 0.99969806763285 0.998909746529476 0.999963432497808 NA 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Ala53Val tsnR_p.Ala53Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Ala54Val tsnR_p.Ala54Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 2 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Ala76Thr tsnR_p.Ala76Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Arg142Leu tsnR_p.Arg142Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 373 17436 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 113.680929631125 1 232 852 False False 0 0 113.680929631125 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Arg22Gly tsnR_p.Arg22Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Arg22His tsnR_p.Arg22His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Arg260Pro tsnR_p.Arg260Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Arg56Trp tsnR_p.Arg56Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Arg5Ser tsnR_p.Arg5Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Asn241Lys tsnR_p.Asn241Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Asp196Glu tsnR_p.Asp196Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 838 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 510 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Asp81His tsnR_p.Asp81His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 1 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Cys92Arg tsnR_p.Cys92Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 372 17439 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 1 0.999788491924625 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 842 852 False False Inf 1.19880183801736 Inf 0 0 0.00986733780971405 1 0.999788491924625 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 136 6624 0.0072992700729927 0.00018478444338478 0.0399968206735547 1 0.99944325898497 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 514 516 False False 0 0 0 0 0 0 0 Inf 1.23975059493345 Inf 0 0 0.0267595583791432 1 0.99944325898497 1 NA 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Glu100fs tsnR_p.Glu100fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Glu73Ala tsnR_p.Glu73Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Glu73Lys tsnR_p.Glu73Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 373 17435 0 0 0.0098410144176726 0.99977062904983 0.999412824358174 0.99993750071294 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 113.674326546033 1 232 852 False False 0 0 70.9839175273221 0 0 0.0098410144176726 0.99977062904983 0.999412824358174 0.99993750071294 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 511 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Gly105fs tsnR_p.Gly105fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Gly123Ser tsnR_p.Gly123Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Gly141Arg tsnR_p.Gly141Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 249.394754138913 1 45.5 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Gly149Asp tsnR_p.Gly149Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Gly181fs tsnR_p.Gly181fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 372 17439 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 1 0.999788491924625 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 1.19880183801736 Inf 0.0209409386930159 8.5 852 False False Inf 1.19880183801736 Inf 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 1 0.999788491924625 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Gly20Cys tsnR_p.Gly20Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 2 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Gly25Arg tsnR_p.Gly25Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Ile110Thr tsnR_p.Ile110Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Ile126Val tsnR_p.Ile126Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 373 17436 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 249.380449704342 1 232 852 False False 0 0 113.680929631125 0 0 0.0098410144176726 0.999827971787373 0.999497343686186 0.999964522241709 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 137 6621 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 258.364277567031 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 117.538380750032 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 NA 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Ile138fs tsnR_p.Ile138fs 2 frameshift (see "Genomic_coordinates" sheet) 1 4 0 4 3 5 370 17434 0.00804289544235925 0.00166171954284036 0.0233236515558583 0.999713286312288 0.999331033812208 0.999906898501965 0.375 0.0852334141372535 0.755136783633448 0 0 0.602364635616474 0 0 0.521823750104981 0 0 71.556228899408 1 232 852 False False 28.2713513513513 4.36999911737579 145.664268675747 0 0 0.00992040933174687 0.999713286312288 0.999331033812208 0.999906898501965 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 2 5 135 6619 0.0145985401459854 0.00177286642699366 0.0517388975821079 0.999245169082125 0.998239362946804 0.999754864475697 0.285714285714285 0.0366925661760855 0.709579136262657 0 0 0.602364635616474 0 0 0.521823750104981 0 0 74.7864383369786 1 16.5 516 False False 0 0 0 0 0 0 0 19.6118518518518 1.84841156997636 120.492389386339 0 0 0.0269550815831828 0.999245169082125 0.998239362946804 0.999754864475697 2 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Ile159Met tsnR_p.Ile159Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Ile221Met tsnR_p.Ile221Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 16 0 16 0 17 373 17422 0 0 0.0098410144176726 0.999025173461781 0.998439665579061 0.999432028313824 0 0 0.195064322969093 0 0 0.205907214207822 0 0 0.195064322969093 0 0 12.1602241576015 1 232 852 False False 0 0 11.3647229722871 0 0 0.0098410144176726 0.999025173461781 0.998439665579061 0.999432028313824 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 0 11 0 12 137 6612 0 0 0.0265668510962833 0.998188405797101 0.996837650049707 0.999063583479635 0 0 0.264648469397051 0 0 0.284914152918154 0 0 0.264648469397051 0 0 19.4398816545596 1 16.5 516 False False 0 0 0 0 0 0 0 0 0 17.5644878047804 0 0 0.0265668510962833 0.998188405797101 0.996837650049707 0.999063583479635 140 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Ile221Ser tsnR_p.Ile221Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 847 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Leu139Phe tsnR_p.Leu139Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Leu152Met tsnR_p.Leu152Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 9 0 9 0 11 373 17428 0 0 0.0098410144176726 0.999369229887034 0.998871658968789 0.999685081116298 0 0 0.284914152918154 0 0 0.336267116879942 0 0 0.284914152918154 0 0 23.7486424676017 1 232 852 False False 0 0 18.6911206624175 0 0 0.0098410144176726 0.999369229887034 0.998871658968789 0.999685081116298 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 0 10 137 6614 0 0 0.0265668510962833 0.998490338164251 0.997225436330416 0.999275828568208 0 0 0.30849710781876 0 0 0.336267116879942 0 0 0.30849710781876 0 0 24.7106202078939 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 21.7720387329624 0 0 0.0265668510962833 0.998490338164251 0.997225436330416 0.999275828568208 7 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Leu202Phe tsnR_p.Leu202Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 852 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Leu232Pro tsnR_p.Leu232Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 329 16292 44 1147 0.882037533512064 0.844890222326356 0.912966473025299 0.0657721199610069 0.0621370514079529 0.0695527962215586 0.0197942362072077 0.0177308905966813 0.0220279361203848 NA NA NA 0 0 0.000226397118985727 NA NA NA NA 848 852 False True 0.526419826797312 0.3810314008188 0.742765239309259 0 0 0.0804199397635758 0.0657721199610069 0.0621370514079529 0.0695527962215586 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 120 6238 17 386 0.875912408759124 0.808770866500967 0.926024653102757 0.0582729468599033 0.0527515694651388 0.064187059893893 0.0188738597043095 0.0156724540988252 0.0225266772407227 NA NA NA 0 0 0.000591181299834831 NA NA NA NA 516 516 False True 1 1 1 0 0 0 0 0.436791581012013 0.258446808730567 0.782904900449712 0 0 0.195064322969093 0.0582729468599033 0.0527515694651388 0.064187059893893 30600 5) Not assoc w R New NotAwR yes 5 +Linezolid tsnR p.Leu28Ile tsnR_p.Leu28Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Leu28Phe tsnR_p.Leu28Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 372 17439 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 1 0.999788491924625 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 844 852 False False Inf 1.19880183801736 Inf 0 0 0.00986733780971405 1 0.999788491924625 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Leu28Pro tsnR_p.Leu28Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Leu39Phe tsnR_p.Leu39Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Leu61Val tsnR_p.Leu61Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Leu99Phe tsnR_p.Leu99Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 249.394754138913 1 45.5 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Met132Ile tsnR_p.Met132Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 249.394754138913 1 45.5 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 1 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Phe210Leu tsnR_p.Phe210Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Pro85Leu tsnR_p.Pro85Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 372 17439 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 1 0.999788491924625 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 839 852 False False Inf 1.19880183801736 Inf 0 0 0.00986733780971405 1 0.999788491924625 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 136 6624 0.0072992700729927 0.00018478444338478 0.0399968206735547 1 0.99944325898497 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 512 516 False False 0 0 0 0 0 0 0 Inf 1.23975059493345 Inf 0 0 0.0267595583791432 1 0.99944325898497 1 NA 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Ser218Thr tsnR_p.Ser218Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 NA 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Ser234Pro tsnR_p.Ser234Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 9 0 9 0 11 373 17428 0 0 0.0098410144176726 0.999369229887034 0.998871658968789 0.999685081116298 0 0 0.284914152918154 0 0 0.336267116879942 0 0 0.284914152918154 0 0 23.7486424676017 1 232 852 False False 0 0 18.6911206624175 0 0 0.0098410144176726 0.999369229887034 0.998871658968789 0.999685081116298 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 0 10 137 6614 0 0 0.0265668510962833 0.998490338164251 0.997225436330416 0.999275828568208 0 0 0.30849710781876 0 0 0.336267116879942 0 0 0.30849710781876 0 0 24.7106202078939 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 21.7720387329624 0 0 0.0265668510962833 0.998490338164251 0.997225436330416 0.999275828568208 6 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Ser239Cys tsnR_p.Ser239Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Ser239Thr tsnR_p.Ser239Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 373 17435 0 0 0.0098410144176726 0.99977062904983 0.999412824358174 0.99993750071294 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 113.674326546033 1 232 852 False False 0 0 70.9839175273221 0 0 0.0098410144176726 0.99977062904983 0.999412824358174 0.99993750071294 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 137 6621 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 258.364277567031 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 117.538380750032 0 0 0.0265668510962833 0.999547101449275 0.998677014323056 0.999906591690576 16 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Ser80Pro tsnR_p.Ser80Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 9 373 17430 0 0 0.0098410144176726 0.999483915362119 0.999020537685852 0.999763986951471 0 0 0.336267116879942 0 0 0.409616397225003 0 0 0.336267116879942 0 0 32.531847103009 1 232 852 False False 0 0 23.7503925717735 0 0 0.0098410144176726 0.999483915362119 0.999020537685852 0.999763986951471 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 9 137 6615 0 0 0.0265668510962833 0.998641304347826 0.99742234629094 0.999378535554749 0 0 0.336267116879942 0 0 0.409616397225003 0 0 0.336267116879942 0 0 33.839009385647 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 24.7143596106325 0 0 0.0265668510962833 0.998641304347826 0.99742234629094 0.999378535554749 2 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Thr11Ala tsnR_p.Thr11Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Thr124Met tsnR_p.Thr124Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Thr156fs tsnR_p.Thr156fs 2 frameshift (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 373 17433 0 0 0.0098410144176726 0.999655943574746 0.999251285574099 0.999873727224798 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 39.8653094124675 1 232 852 False False 0 0 39.8653094124675 0 0 0.0098410144176726 0.999655943574746 0.999251285574099 0.999873727224798 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 137 6618 0 0 0.0265668510962833 0.99909420289855 0.998029511465385 0.999667518193072 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 41.3735817198596 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 41.3735817198596 0 0 0.0265668510962833 0.99909420289855 0.998029511465385 0.999667518193072 5 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Thr3Ile tsnR_p.Thr3Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 137 6623 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1831.72385186727 1 104.5 516 False False 0 0 0 0 0 0 0 0 0 1831.72385186727 0 0 0.0265668510962833 0.999849033816425 0.999159160462165 0.999996177874456 1 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Thr82Lys tsnR_p.Thr82Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 373 17437 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 1772.79911553209 1 232 852 False False 0 0 249.394754138913 0 0 0.0098410144176726 0.999885314524915 0.999585778685812 0.999986110755134 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Trp208* tsnR_p.Trp208* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 372 17439 0.00268096514745308 6.78738572813057e-05 0.0148461631106886 1 0.999788491924625 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 851 852 False False Inf 1.19880183801736 Inf 0 0 0.00986733780971405 1 0.999788491924625 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Tyr147Cys tsnR_p.Tyr147Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 9 721 364 16718 0.0241286863270777 0.01109119215689 0.0453081868054267 0.958655886232008 0.955594968145822 0.961562623228982 0.0123287671232876 0.00565257234228517 0.0232743516460269 NA NA NA 0 0 0.00510327149933527 NA NA NA NA 846 852 False True 0.573310877749157 0.258973899742481 1.10675349900238 0 0 0.0100831053891569 0.958655886232008 0.955594968145822 0.961562623228982 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 2 392 135 6232 0.0145985401459854 0.00177286642699366 0.0517388975821079 0.940821256038647 0.934866658546363 0.946383971724218 0.00507614213197969 0.000615336625234349 0.0182155939609769 NA NA NA 0 0 0.00936626745770974 NA NA NA NA 515 516 False True 1 1 1 0 0 0 0 0.235525321239606 0.0281347936834924 0.873504849309867 0 0 0.0269550815831828 0.940821256038647 0.934866658546363 0.946383971724218 1820 5) Not assoc w R New NotAwR yes 5 +Linezolid tsnR p.Tyr251His tsnR_p.Tyr251His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 850 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Val137Leu tsnR_p.Val137Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 843 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Val144Ile tsnR_p.Val144Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Val170Ile tsnR_p.Val170Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Val242Ala tsnR_p.Val242Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 373 17435 0 0 0.0098410144176726 0.99977062904983 0.999412824358174 0.99993750071294 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 70.9839175273221 1 232 852 False False 0 0 70.9839175273221 0 0 0.0098410144176726 0.99977062904983 0.999412824358174 0.99993750071294 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Linezolid tsnR p.Val89Leu tsnR_p.Val89Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 373 17438 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 0 0 0.975 0 0 0.975 0 0 0.975 0 0 1772.89796229585 1 232 852 False False 0 0 1772.89796229585 0 0 0.0098410144176726 0.999942657262457 0.999680548589877 0.999998548208635 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK c.1011G>A glpK_c.1011G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.1035G>A glpK_c.1035G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.1050C>T glpK_c.1050C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 11.2104345733627 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.22785363871091 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.1071C>A glpK_c.1071C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.1089G>A glpK_c.1089G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.1102C>T glpK_c.1102C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 31 4002 18504 0 0 0.000921334294721226 0.998327488535203 0.997626836277036 0.998863335475117 0 0 0.11218874692237 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.58462099865308 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 12 1742 6628 0 0 0.00211537106925253 0.998192771084337 0.996845265024717 0.999065840721332 0 0 0.264648469397051 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.37098656231317 NA NA NA NA NA NA 17 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.1134C>T glpK_c.1134C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 289 2078 3713 16457 0.0722138930534732 0.0643840922470342 0.0806749080322258 0.88788777987591 0.883257716640743 0.892395760706886 0.122095479509928 0.109168646261308 0.135965385161042 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.616421842772331 0.540422114465315 0.701179113822776 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 147 858 1595 5782 0.0843857634902411 0.0717541296738133 0.0984370719015528 0.87078313253012 0.862476557729002 0.878762554202172 0.146268656716417 0.124984871199263 0.169647600266868 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 0 0.621079860578293 0.513348555922109 0.747559191399111 NA NA NA NA NA NA 3427 5) Not assoc w R Now listed Silent mutation no 0 +Moxifloxacin glpK c.1137C>T glpK_c.1137C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.1164C>T glpK_c.1164C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.117G>C glpK_c.117G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 5 4000 18530 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 0.999730240086323 0.999370583585258 0.99991240407437 0.285714285714285 0.0366925661760855 0.709579136262657 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.853 0.176375644908091 11.3239281818414 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 1 1740 6639 0.00114810562571756 0.000139071172424607 0.00414113746933503 0.999849397590361 0.999161185884076 0.99999618708438 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 7.63103448275862 0.396930405600961 448.930838944076 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.1209C>T glpK_c.1209C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.120C>T glpK_c.120C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.123C>A glpK_c.123C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 6 19 3996 18516 0.00149925037481259 0.000550390926465245 0.00326035944931569 0.998974912328028 0.998399659444322 0.999382720987534 0.24 0.0935644393317428 0.451288017816686 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.46325272641062 0.477974198700035 3.81396236052356 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 6 9 1736 6631 0.00344431687715269 0.00126502019745104 0.00748164597286304 0.998644578313253 0.997428553721748 0.999380033497835 0.4 0.163364323859513 0.677130233793718 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.54646697388632 0.744685370451 8.02209745357392 NA NA NA NA NA NA 17 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.1245C>T glpK_c.1245C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.1257C>G glpK_c.1257C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.1260G>A glpK_c.1260G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 20.3050873563561 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.1267T>C glpK_c.1267T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.1269G>A glpK_c.1269G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 4002 18529 0 0 0.000921334294721226 0.999676288103587 0.999295549654279 0.999881194471086 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.93385874811763 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 1742 6636 0 0 0.00211537106925253 0.999397590361445 0.998458316867766 0.999835840034063 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 5.77543554850383 NA NA NA NA NA NA 22 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.129G>A glpK_c.129G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.1302G>A glpK_c.1302G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.1305T>C glpK_c.1305T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.1317G>A glpK_c.1317G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 3999 18535 0.000749625187406296 0.000154617422592445 0.00218914487959466 1 0.999800997443015 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.91440039171731 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.1329G>A glpK_c.1329G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 4.63234191452137 0.0589984289392935 362.546724531758 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.1341G>T glpK_c.1341G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 8 4002 18527 0 0 0.000921334294721226 0.999568384138117 0.999149722782159 0.999813641077243 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.7132714326819 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 6 1742 6634 0 0 0.00211537106925253 0.999096385542168 0.998034257105878 0.999668319522948 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.23733664541029 NA NA NA NA NA NA 15 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.-13A>G glpK_c.-13A>G 2 upstream_gene_variant 4139768 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK c.1422G>A glpK_c.1422G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.1437C>G glpK_c.1437C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.1446A>C glpK_c.1446A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 5 4001 18530 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999730240086323 0.999370583585258 0.99991240407437 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.926268432891777 0.0195789744788398 8.28271147593069 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 5 1741 6635 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999246987951807 0.99824360331506 0.999755455269461 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.76220562894888 0.016109698917676 6.81778471156948 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.1497T>G glpK_c.1497T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.1503C>T glpK_c.1503C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.1518G>A glpK_c.1518G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.1527G>A glpK_c.1527G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 1 4000 18534 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 0.999946048017264 0.999699435860871 0.999998634054993 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 9.267 0.482236652039982 544.73752523911 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.1530C>T glpK_c.1530C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.153C>T glpK_c.153C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.1542T>C glpK_c.1542T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.1551C>T glpK_c.1551C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 4002 18529 0 0 0.000921334294721226 0.999676288103587 0.999295549654279 0.999881194471086 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.93385874811763 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 5 1742 6635 0 0 0.00211537106925253 0.999246987951807 0.99824360331506 0.999755455269461 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.16029237021718 NA NA NA NA NA NA 11 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.159C>T glpK_c.159C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 11 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.-19T>G glpK_c.-19T>G 2 upstream_gene_variant 4139774 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK c.201C>A glpK_c.201C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.211T>C glpK_c.211T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.234C>G glpK_c.234C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.234C>T glpK_c.234C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.238C>T glpK_c.238C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.246G>A glpK_c.246G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01683899052165 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 20 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.255T>C glpK_c.255T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.264G>A glpK_c.264G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.27A>G glpK_c.27A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 4 4000 18531 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 0.999784192069058 0.999447539013843 0.999941196572055 0.333333333333333 0.0432718682927417 0.777221904496487 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.316375 0.209452463855679 16.1672355802828 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 18 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.309C>T glpK_c.309C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 11.2104345733627 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.315A>G glpK_c.315A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.318G>A glpK_c.318G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 20.3050873563561 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.330C>T glpK_c.330C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.336T>C glpK_c.336T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.33C>T glpK_c.33C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.369G>T glpK_c.369G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.-38C>T glpK_c.-38C>T 2 upstream_gene_variant 4139793 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK c.414G>A glpK_c.414G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.417G>A glpK_c.417G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 24 4001 18511 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.998705152414351 0.99807397809504 0.999170196040018 0.04 0.00101219969931084 0.203516913922414 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.19277472298592 0.00469021311482641 1.18294640354368 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.420C>T glpK_c.420C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.435T>A glpK_c.435T>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.444T>G glpK_c.444T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 4001 18533 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999892096034529 0.999610268708724 0.999986932062044 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.31604598850287 0.0392471382871788 44.494064095996 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 1741 6639 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999849397590361 0.999161185884076 0.99999618708438 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.81332567489948 0.0485516368820753 298.645085154332 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.-47_-45delGCG glpK_c.-47_-45delGCG 2 upstream_gene_variant 4139799 1 4 0 4 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 7.01683899052165 1 732.5 1798 False False 0 0 7.01683899052165 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK c.492G>T glpK_c.492G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.510C>T glpK_c.510C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 42 203 3960 18332 0.0104947526236881 0.00757387125593335 0.0141596424330497 0.98904774750472 0.987443203944765 0.990495959200269 0.171428571428571 0.126431702379833 0.224573247258169 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.95778474399164 0.668787993862148 1.34336902188253 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 21 98 1721 6542 0.0120551090700344 0.00747736474390389 0.0183687588447014 0.985240963855421 0.982042561210634 0.988002092549504 0.176470588235294 0.112683958843826 0.257015012433017 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.814559641404499 0.481275750449676 1.31964362988523 NA NA NA NA NA NA 301 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.525A>G glpK_c.525A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 7 4002 18528 0 0 0.000921334294721226 0.999622336120852 0.999222023868969 0.999848146482689 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.21342445526953 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.531C>T glpK_c.531C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.570G>A glpK_c.570G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.582C>A glpK_c.582C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.-5A>G glpK_c.-5A>G 2 upstream_gene_variant 4139760 1 18 2 16 3 16 3999 18519 0.000749625187406296 0.000154617422592445 0.00218914487959466 0.999136768276234 0.998598543286194 0.999506510531465 0.157894736842105 0.0338262490017646 0.395784551266674 0.111111111111111 0.0137512156643644 0.347120438608672 0.111111111111111 0.0137512156643644 0.347120438608672 0.578863465866466 0.0645436764630834 2.46373627208314 0.756519437735702 187 1798 False False 0.8682951987997 0.162041737172466 3.03548634795269 0.000499875031242189 6.05429192566037e-05 0.00180454187542552 0.999136768276234 0.998598543286194 0.999506510531465 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 2 3 2 3 1740 6637 0.00114810562571756 0.000139071172424607 0.00414113746933503 0.999548192771084 0.998680200855815 0.999906816794257 0.4 0.0527449505263169 0.853367200365326 0.4 0.0527449505263169 0.853367200365326 0.4 0.0527449505263169 0.853367200365326 2.54291187739463 0.212204746732873 22.2132783392172 0.278801283139327 53 886 False False 0 0 0 0 0 0 0 2.54291187739463 0.212204746732873 22.2132783392172 0.00114810562571756 0.000139071172424607 0.00414113746933503 0.999548192771084 0.998680200855815 0.999906816794257 10 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK c.60C>T glpK_c.60C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.624A>C glpK_c.624A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 16 4001 18519 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999136768276234 0.998598543286194 0.999506510531465 0.0588235294117647 0.00148817439126663 0.28688939666722 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.28928705323669 0.00690014745187587 1.86323046421039 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.63C>T glpK_c.63C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.645C>T glpK_c.645C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.708G>A glpK_c.708G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.708G>T glpK_c.708G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.717T>C glpK_c.717T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.717T>G glpK_c.717T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.741G>T glpK_c.741G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 13 4001 18522 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.99929862422444 0.998800924705247 0.999626495767062 0.0714285714285714 0.00180678065912538 0.338684489931821 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.356103281871839 0.00838065664937259 2.37218277523618 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 11 1741 6629 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.998343373493976 0.997037775344334 0.999172737054126 0.0833333333333333 0.00210759323186022 0.384796165150944 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.34614380450107 0.0080407298813373 2.38478511505618 NA NA NA NA NA NA 28 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.759G>A glpK_c.759G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.759G>T glpK_c.759G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.75C>A glpK_c.75C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.75C>T glpK_c.75C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.777C>A glpK_c.777C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.789T>C glpK_c.789T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.795C>T glpK_c.795C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.810C>T glpK_c.810C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.816G>A glpK_c.816G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.84C>T glpK_c.84C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.852C>T glpK_c.852C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.859C>T glpK_c.859C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.873C>T glpK_c.873C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.891A>G glpK_c.891A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 3 4001 18532 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999838144051794 0.999527061819887 0.99996662016845 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.5439473464967 0.0294026895471131 19.2327580431529 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 1741 6639 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999849397590361 0.999161185884076 0.99999618708438 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.81332567489948 0.0485516368820753 298.645085154332 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.900C>T glpK_c.900C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 11.2104345733627 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.906G>A glpK_c.906G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.912C>T glpK_c.912C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 4.63234191452137 0.0589984289392935 362.546724531758 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.921C>T glpK_c.921C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.945C>T glpK_c.945C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.96C>T glpK_c.96C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 5 4001 18530 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999730240086323 0.999370583585258 0.99991240407437 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.926268432891777 0.0195789744788398 8.28271147593069 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 1741 6638 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999698795180722 0.998912372612698 0.9999635206173 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.90637564618035 0.032294587677361 36.6438813236649 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.978C>T glpK_c.978C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin glpK c.-9T>G glpK_c.-9T>G 2 upstream_gene_variant 4139764 NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1637 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK deletion glpK_deletion 2 feature_ablation (see "Genomic_coordinates" sheet) 1 1 0 1 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 180.0913296367 1 732.5 1798 False False 0 0 7.01683899052165 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 806 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 5 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK LoF glpK_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 187 11 176 77 245 3925 18290 0.0192403798100949 0.0152132863194736 0.0239892010036391 0.986781764229835 0.98503202950799 0.988376206876545 0.239130434782608 0.193576827619339 0.289554911586689 0.0588235294117647 0.0297270467333677 0.102812429390155 0.04296875 0.0216420406043031 0.0755809337704292 0.29124203821656 0.142636500541107 0.53469426652749 4.14969299921389e-06 17 1798 True False 1.4645313921747 1.11590709245287 1.9039309653708 0.00279471544715447 0.00139591184813941 0.00499500333305933 0.986781764229835 0.98503202950799 0.988376206876545 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 34 0 34 32 39 1710 6601 0.018369690011481 0.0125979326364575 0.0258342769769089 0.994126506024096 0.991979400901914 0.99582013592543 0.450704225352112 0.332269182323673 0.573381335371861 0 0 0.102817924259012 0 0 0.0902511009603342 0 0 0.443011604383738 0.000857040820086167 12 886 False False 0 0 0 0 0 0 0 3.16737142000299 1.91432961654288 5.20448444528226 0 0 0.00215491427811716 0.994126506024096 0.991979400901914 0.99582013592543 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Ala111Glu glpK_p.Ala111Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Ala11Val glpK_p.Ala11Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 5 4002 18530 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 11.2092253162358 1 732.5 1798 False False 0 0 5.05471226039473 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Ala164Thr glpK_p.Ala164Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1613 1798 False False 4.63234191452137 0.0589984289392935 362.546724531758 0 0 0.000921564464586207 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Ala19Asp glpK_p.Ala19Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Ala245Thr glpK_p.Ala245Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Ala265fs glpK_p.Ala265fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Ala277Gly glpK_p.Ala277Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Ala313Thr glpK_p.Ala313Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 5 4002 18530 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1631 1798 False False 0 0 5.05471226039473 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Ala318Thr glpK_p.Ala318Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1578 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 777 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Ala324Thr glpK_p.Ala324Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1620 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 799 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Ala364Val glpK_p.Ala364Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 1 7 4001 18528 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999622336120852 0.999222023868969 0.999848146482689 0.125 0.0031597235312519 0.526509670875206 0 0 0.602364635616474 0 0 0.409616397225003 0 0 7.01745704247561 1 732.5 1798 False False 0.661548898489663 0.0146783588023133 5.15155114398686 0 0 0.000921564464586207 0.999622336120852 0.999222023868969 0.999848146482689 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 1741 6638 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999698795180722 0.998912372612698 0.9999635206173 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3167233028695 1 345 886 False False 0 0 0 0 0 0 0 1.90637564618035 0.032294587677361 36.6438813236649 0 0 0.00211658481469046 0.999698795180722 0.998912372612698 0.9999635206173 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Ala370fs glpK_p.Ala370fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Ala377Val glpK_p.Ala377Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Ala37Val glpK_p.Ala37Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1603 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 789 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Ala396fs glpK_p.Ala396fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Ala396Ser glpK_p.Ala396Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1632 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 805 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Ala400Val glpK_p.Ala400Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Ala440Gly glpK_p.Ala440Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1636 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Ala453Val glpK_p.Ala453Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 180.110710654533 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Ala457Ser glpK_p.Ala457Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1601 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 788 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Ala467Val glpK_p.Ala467Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1573 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 773 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Ala472Pro glpK_p.Ala472Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1604 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 790 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Ala479Thr glpK_p.Ala479Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Ala498Gly glpK_p.Ala498Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Ala498Thr glpK_p.Ala498Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Ala498Val glpK_p.Ala498Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Ala53Val glpK_p.Ala53Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Arg102Trp glpK_p.Arg102Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Arg121Cys glpK_p.Arg121Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 3999 18535 0.000749625187406296 0.000154617422592445 0.00218914487959466 1 0.999800997443015 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1616 1798 False False Inf 1.91440039171731 Inf 0 0 0.000922025149498025 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Arg121Ser glpK_p.Arg121Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1625 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Arg189Gln glpK_p.Arg189Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Arg225Trp glpK_p.Arg225Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.118748254282209 Inf 0.177582534611288 85 1798 False False 4.63234191452137 0.0589984289392935 362.546724531758 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0977360898734989 Inf 0.207826294440467 35.5 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Arg334Gly glpK_p.Arg334Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Arg395Ser glpK_p.Arg395Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Arg406Cys glpK_p.Arg406Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Arg41Cys glpK_p.Arg41Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Arg478Gln glpK_p.Arg478Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1608 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Arg509Trp glpK_p.Arg509Trp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1568 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Arg66Ser glpK_p.Arg66Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Arg94Leu glpK_p.Arg94Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Asn183Ser glpK_p.Asn183Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1592 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Asn279fs glpK_p.Asn279fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 4000 18535 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 1 0.999800997443015 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1629 1798 False False Inf 0.869940791113183 Inf 0 0 0.000921794749483055 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 1740 6640 0.00114810562571756 0.000139071172424607 0.00414113746933503 1 0.999444600156968 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 804 886 False False 0 0 0 0 0 0 0 Inf 0.716065670156237 Inf 0 0 0.00211779995375925 1 0.999444600156968 1 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Asn279Lys glpK_p.Asn279Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.118754661339467 Inf 0.177574655011758 72.5 1798 False False Inf 0.118754661339467 Inf 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0977360898734989 Inf 0.207826294440467 35.5 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Asn285fs glpK_p.Asn285fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Asn299Asp glpK_p.Asn299Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 14 14 3988 18521 0.00349825087456271 0.00191380546833921 0.00586251148053981 0.999244672241704 0.998733012789936 0.999586995715357 0.5 0.306470961532318 0.693529038467682 0 0 0.369416647552819 0 0 0.231635761650116 0 0 2.72191692342318 0.365189814513371 113 1798 False False 4.64418254764292 2.05027307686266 10.5179209363133 0 0 0.000924567172214373 0.999244672241704 0.998733012789936 0.999586995715357 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 3 4 1739 6636 0.00172215843857634 0.000355291378803123 0.00502455256196275 0.999397590361445 0.998458316867766 0.999835840034063 0.428571428571428 0.0989882784425078 0.815948432359917 0 0 0.841886116991581 0 0 0.602364635616474 0 0 20.3339240254502 1 345 886 False False 0 0 0 0 0 0 0 2.86198964922369 0.41878325287878 16.9296564860373 0 0 0.00211901648886052 0.999397590361445 0.998458316867766 0.999835840034063 9 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Asn312Lys glpK_p.Asn312Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1582 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Asn59Asp glpK_p.Asn59Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Asn59Ser glpK_p.Asn59Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1597 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Asn76Lys glpK_p.Asn76Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Asp120Ala glpK_p.Asp120Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Asp120Asn glpK_p.Asp120Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Asp160Asn glpK_p.Asp160Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 6 4002 18529 0 0 0.000921334294721226 0.999676288103587 0.999295549654279 0.999881194471086 0 0 0.4592581264399 0 0 0.975 0 0 0.4592581264399 0 0 180.071948607096 1 732.5 1798 False False 0 0 3.93385874811763 0 0 0.000921334294721226 0.999676288103587 0.999295549654279 0.999881194471086 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 785 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Asp170Glu glpK_p.Asp170Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Asp177Asn glpK_p.Asp177Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Asp177Gly glpK_p.Asp177Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Asp214Val glpK_p.Asp214Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Asp376Asn glpK_p.Asp376Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Asp3Asn glpK_p.Asp3Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1574 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 774 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Asp407Asn glpK_p.Asp407Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1583 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Asp407Glu glpK_p.Asp407Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Asp446Tyr glpK_p.Asp446Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 11.2104345733627 1 732.5 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Asp484Asn glpK_p.Asp484Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Asp492Gly glpK_p.Asp492Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Asp493fs glpK_p.Asp493fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Asp84Glu glpK_p.Asp84Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 24 0 24 1 24 4001 18511 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.998705152414351 0.99807397809504 0.999170196040018 0.04 0.00101219969931084 0.203516913922414 0 0 0.142473597722525 0 0 0.142473597722525 0 0 0.769109405666779 0.0144854772472567 30 1798 False False 0.19277472298592 0.00469021311482641 1.18294640354368 0 0 0.000921564464586207 0.998705152414351 0.99807397809504 0.999170196040018 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 1742 6634 0 0 0.00211537106925253 0.999096385542168 0.998034257105878 0.999668319522948 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.23733664541029 0.355668965817841 60.5 886 False False 0 0 0 0 0 0 0 0 0 3.23733664541029 0 0 0.00211537106925253 0.999096385542168 0.998034257105878 0.999668319522948 19 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Cys271Arg glpK_p.Cys271Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Cys271Tyr glpK_p.Cys271Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1605 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Cys29Tyr glpK_p.Cys29Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 11 0 11 3 25 3999 18510 0.000749625187406296 0.000154617422592445 0.00218914487959466 0.998651200431615 0.998009545263528 0.999126943780254 0.107142857142857 0.0226650906390589 0.282264395715324 0 0 0.284914152918154 0 0 0.137185171530712 0 0 1.84511504057892 0.231452330605987 96 1798 False False 0.555438859714928 0.107278571608732 1.82169499024317 0 0 0.000922025149498025 0.998651200431615 0.998009545263528 0.999126943780254 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 1 17 1741 6623 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.997439759036144 0.995903960705664 0.998507879902128 0.0555555555555555 0.00140555616736942 0.272943599673368 0 0 0.369416647552819 0 0 0.195064322969093 0 0 2.23101653904785 0.21852571905937 41 886 False False 0 0 0 0 0 0 0 0.223772679663479 0.00535502511025759 1.43021074798802 0 0 0.00211658481469046 0.997439759036144 0.995903960705664 0.998507879902128 151 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Cys307Arg glpK_p.Cys307Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Gln262Arg glpK_p.Gln262Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1609 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 792 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Gln336His glpK_p.Gln336His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1617 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Gln404Glu glpK_p.Gln404Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Gln508* glpK_p.Gln508* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Gln9Glu glpK_p.Gln9Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 180.0913296367 1 732.5 1798 False False 0 0 7.01683899052165 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 798 886 False False 0 0 0 0 0 0 0 0 0 9.22785363871091 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Glu157Gly glpK_p.Glu157Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1586 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Glu167Gly glpK_p.Glu167Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1623 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Glu209Lys glpK_p.Glu209Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 7.01683899052165 1 732.5 1798 False False 0 0 7.01683899052165 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 74 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Glu230Ala glpK_p.Glu230Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 5 4002 18530 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 0 0 0.521823750104981 0 0 0.975 0 0 0.521823750104981 0 0 180.08163912337 1 732.5 1798 False False 0 0 5.05471226039473 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 794 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 10 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Glu230Lys glpK_p.Glu230Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1593 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Glu276Gly glpK_p.Glu276Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 3 4001 18532 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999838144051794 0.999527061819887 0.99996662016845 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 24.6676166728131 1 732.5 1798 False False 1.5439473464967 0.0294026895471131 19.2327580431529 0 0 0.000921564464586207 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 803 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Glu320Lys glpK_p.Glu320Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Glu38Gly glpK_p.Glu38Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 4000 18535 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 1 0.999800997443015 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1621 1798 False False Inf 0.869940791113183 Inf 0 0 0.000921794749483055 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 800 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Glu413Lys glpK_p.Glu413Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Glu495Gly glpK_p.Glu495Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Gly140Asp glpK_p.Gly140Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1594 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Gly161Glu glpK_p.Gly161Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1584 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Gly169Arg glpK_p.Gly169Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1587 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 780 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Gly187Glu glpK_p.Gly187Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.118754661339467 Inf 0.177574655011758 72.5 1798 False False Inf 0.118754661339467 Inf 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Gly191dup glpK_p.Gly191dup 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 6 0 6 0 12 4002 18523 0 0 0.000921334294721226 0.999352576207175 0.998869354319296 0.999665423355947 0 0 0.264648469397051 0 0 0.4592581264399 0 0 0.264648469397051 0 0 3.93258497725267 0.599077725679273 172 1798 False False 0 0 1.66656583988199 0 0 0.000921334294721226 0.999352576207175 0.998869354319296 0.999665423355947 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 778 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 72 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Gly191fs glpK_p.Gly191fs 2 frameshift (see "Genomic_coordinates" sheet) 1 13 0 13 1 13 4001 18522 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.99929862422444 0.998800924705247 0.999626495767062 0.0714285714285714 0.00180678065912538 0.338684489931821 0 0 0.24705263800047 0 0 0.24705263800047 0 0 1.51972010993998 0.143384534327225 53 1798 False False 0.356103281871839 0.00838065664937259 2.37218277523618 0 0 0.000921564464586207 0.99929862422444 0.998800924705247 0.999626495767062 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 24 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Gly247Trp glpK_p.Gly247Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Gly260Ala glpK_p.Gly260Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1614 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 796 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 44 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Gly311Glu glpK_p.Gly311Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1577 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Gly338Asp glpK_p.Gly338Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Gly342dup glpK_p.Gly342dup 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Gly379Ser glpK_p.Gly379Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1569 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Gly417Ser glpK_p.Gly417Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1634 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Gly465Ala glpK_p.Gly465Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Gly89Ala glpK_p.Gly89Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.His103Arg glpK_p.His103Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 180.110710654533 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.His103Asn glpK_p.His103Asn 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1602 1798 False False 4.63234191452137 0.0589984289392935 362.546724531758 0 0 0.000921564464586207 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.His103Tyr glpK_p.His103Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 180.110710654533 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.His193fs glpK_p.His193fs 2 frameshift (see "Genomic_coordinates" sheet) 1 4 2 2 2 2 4000 18533 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 0.999892096034529 0.999610268708724 0.999986932062044 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 4.63325 0.335715582549978 63.989229087488 0.147369199731863 56 1798 False False 4.63325 0.335715582549978 63.989229087488 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 12 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.His263Tyr glpK_p.His263Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.His392Gln glpK_p.His392Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1588 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.His42Tyr glpK_p.His42Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.His58Arg glpK_p.His58Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Ile112Val glpK_p.Ile112Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1575 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 775 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Ile223Thr glpK_p.Ile223Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1622 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Ile401Met glpK_p.Ile401Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Ile429Thr glpK_p.Ile429Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1579 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Ile49Thr glpK_p.Ile49Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Ile5Thr glpK_p.Ile5Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Ile90fs glpK_p.Ile90fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Leu141Met glpK_p.Leu141Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Leu152Arg glpK_p.Leu152Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Leu152Val glpK_p.Leu152Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Leu218Val glpK_p.Leu218Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1598 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 786 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Leu228Val glpK_p.Leu228Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 163 4002 18372 0 0 0.000921334294721226 0.991205826814135 0.989754826030474 0.992499395087564 0 0 0.0223769984930192 0 0 0.841886116991581 0 0 0.0223769984930192 0 0 24.4486725450336 1 732.5 1798 False False 0 0 0.105150892189406 0 0 0.000921334294721226 0.991205826814135 0.989754826030474 0.992499395087564 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 807 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 359 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Leu259Phe glpK_p.Leu259Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Leu272Val glpK_p.Leu272Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Leu287Pro glpK_p.Leu287Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1611 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 795 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Leu319Arg glpK_p.Leu319Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Leu333Ile glpK_p.Leu333Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 9 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Leu368Arg glpK_p.Leu368Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Leu393Val glpK_p.Leu393Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1610 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 793 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Leu398Met glpK_p.Leu398Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Leu466Phe glpK_p.Leu466Phe 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 6 3999 18529 0.000749625187406296 0.000154617422592445 0.00218914487959466 0.999676288103587 0.999295549654279 0.999881194471086 0.333333333333333 0.0748546314196918 0.700704943791459 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1567 1798 False False 2.31670417604401 0.374722402274001 10.8496491446151 0 0 0.000922025149498025 0.999676288103587 0.999295549654279 0.999881194471086 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 5 1739 6635 0.00172215843857634 0.000355291378803123 0.00502455256196275 0.999246987951807 0.99824360331506 0.999755455269461 0.375 0.0852334141372535 0.755136783633448 NA NA NA 0 0 0.521823750104981 NA NA NA NA 771 886 False False 0 0 0 0 0 0 0 2.28924669350201 0.355118546302015 11.7805184875551 0 0 0.00211901648886052 0.999246987951807 0.99824360331506 0.999755455269461 6 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Lys505Asn glpK_p.Lys505Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1570 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Lys83Glu glpK_p.Lys83Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1626 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Met266fs glpK_p.Met266fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Met30Val glpK_p.Met30Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1589 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 781 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Met359Ile glpK_p.Met359Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Met412Ile glpK_p.Met412Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 7.01683899052165 1 732.5 1798 False False 0 0 7.01683899052165 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 4 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Met412Thr glpK_p.Met412Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1630 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Met412Val glpK_p.Met412Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Phe16Leu glpK_p.Phe16Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Phe16Ser glpK_p.Phe16Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Phe32Cys glpK_p.Phe32Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Phe365Leu glpK_p.Phe365Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1627 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 801 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Phe369Leu glpK_p.Phe369Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Pro176Leu glpK_p.Pro176Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Pro176Ser glpK_p.Pro176Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Pro236Ala glpK_p.Pro236Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1606 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 791 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Pro248Ser glpK_p.Pro248Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1599 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 787 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Pro254fs glpK_p.Pro254fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1615 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 797 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Pro254Ser glpK_p.Pro254Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1639 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 809 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Pro274Leu glpK_p.Pro274Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 180.16529327284 1 732.5 1798 False False 4.63234191452137 0.0589984289392935 362.546724531758 0 0 0.000921564464586207 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Pro315Leu glpK_p.Pro315Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1628 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 802 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 6 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Pro354Thr glpK_p.Pro354Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Pro363Arg glpK_p.Pro363Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Pro371Ser glpK_p.Pro371Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Pro489Arg glpK_p.Pro489Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Pro51Ala glpK_p.Pro51Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Pro82Leu glpK_p.Pro82Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Ser124Leu glpK_p.Ser124Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1595 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 783 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Ser124Pro glpK_p.Ser124Pro 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 2 4001 18533 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999892096034529 0.999610268708724 0.999986932062044 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1607 1798 False False 2.31604598850287 0.0392471382871788 44.494064095996 0 0 0.000921564464586207 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Ser124Trp glpK_p.Ser124Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1590 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Ser237Ala glpK_p.Ser237Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Ser416Tyr glpK_p.Ser416Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 2 4 4000 18531 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 0.999784192069058 0.999447539013843 0.999941196572055 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.602364635616474 0 0 0.602364635616474 0 0 7.0203482826284 1 732.5 1798 False False 2.316375 0.209452463855679 16.1672355802828 0 0 0.000921794749483055 0.999784192069058 0.999447539013843 0.999941196572055 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Ser517Cys glpK_p.Ser517Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1638 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 808 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Ser73Trp glpK_p.Ser73Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Thr117Ile glpK_p.Thr117Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Thr185Ile glpK_p.Thr185Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1571 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 772 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Thr203Ala glpK_p.Thr203Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1591 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 782 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Thr256Ile glpK_p.Thr256Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1596 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 784 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Thr280Ala glpK_p.Thr280Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1572 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Thr280Asn glpK_p.Thr280Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Thr283fs glpK_p.Thr283fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Thr294Met glpK_p.Thr294Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Thr326Ala glpK_p.Thr326Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Thr326fs glpK_p.Thr326fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Thr326Ser glpK_p.Thr326Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1580 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Thr397Ala glpK_p.Thr397Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1635 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Thr397Met glpK_p.Thr397Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Thr430Ala glpK_p.Thr430Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 17 0 17 1 26 4001 18509 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.99859724844888 0.997945314710086 0.999083477869708 0.037037037037037 0.000937257091944708 0.189705617413044 0 0 0.195064322969093 0 0 0.132274604497754 0 0 1.12165060478536 0.0564710286441084 42 1798 False False 0.177926672178109 0.00434245972367956 1.08375021900109 0 0 0.000921564464586207 0.99859724844888 0.997945314710086 0.999083477869708 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 0 11 1742 6629 0 0 0.00211537106925253 0.998343373493976 0.997037775344334 0.999172737054126 0 0 0.284914152918154 0 0 0.336267116879942 0 0 0.284914152918154 0 0 1.93010428815532 0.218937200287673 48 886 False False 0 0 0 0 0 0 0 0 0 1.51801526894139 0 0 0.00211537106925253 0.998343373493976 0.997037775344334 0.999172737054126 25 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Thr455fs glpK_p.Thr455fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.118754661339467 Inf 0.177574655011758 72.5 1798 False False Inf 0.118754661339467 Inf 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Thr488Ile glpK_p.Thr488Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Thr490Met glpK_p.Thr490Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Thr78Ala glpK_p.Thr78Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1612 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Trp114Arg glpK_p.Trp114Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Trp114* glpK_p.Trp114* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Trp213* glpK_p.Trp213* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Trp481Gly glpK_p.Trp481Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1600 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Trp487fs glpK_p.Trp487fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Trp513Arg glpK_p.Trp513Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Tyr281* glpK_p.Tyr281* 2 stop_gained (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Tyr308His glpK_p.Tyr308His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 180.110710654533 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 810 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Tyr372Cys glpK_p.Tyr372Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1585 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 779 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Tyr462fs glpK_p.Tyr462fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1618 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Val113Ala glpK_p.Val113Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1581 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Val113Ile glpK_p.Val113Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Val159Ile glpK_p.Val159Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Val192fs glpK_p.Val192fs 2 frameshift (see "Genomic_coordinates" sheet) 1 153 8 145 71 207 3931 18328 0.0177411294352823 0.0138813015086007 0.0223259954829269 0.988831939573779 0.987212935753957 0.990294714769639 0.255395683453237 0.205187795423066 0.310901103446911 0.0522875816993464 0.0228414056226665 0.100426182881888 0.0372093023255813 0.0161988660877392 0.0719980758439036 0.257237344187229 0.108902988225624 0.521115488274089 8.97575841643879e-06 20 1798 True False 1.59918989034271 1.20090973248485 2.10860245513388 0.00203097232800203 0.00087722471638886 0.0039978823937537 0.988831939573779 0.987212935753957 0.990294714769639 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 29 0 29 30 32 1712 6608 0.0172215843857634 0.0116487242457747 0.0244942205072294 0.995180722891566 0.993203371238921 0.996701352347567 0.483870967741935 0.35497275682746 0.614360876025932 0 0 0.119444869069502 0 0 0.108881160679352 0 0 0.524291038779864 0.00202135309004858 14 886 False False 0 0 0 0 0 0 0 3.61857476635514 2.11730743744069 6.1660641305671 0 0 0.00215239956609241 0.995180722891566 0.993203371238921 0.996701352347567 458 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Val192Met glpK_p.Val192Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1624 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Val253Leu glpK_p.Val253Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 4 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Val267Ile glpK_p.Val267Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1619 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Val353Phe glpK_p.Val353Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Val382Ala glpK_p.Val382Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Val39Leu glpK_p.Val39Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Val418Asp glpK_p.Val418Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Val442Met glpK_p.Val442Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Val452Leu glpK_p.Val452Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1633 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Val460Ala glpK_p.Val460Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 71 1625 3931 16910 0.0177411294352823 0.0138813015086007 0.0223259954829269 0.912328028055031 0.908164543099672 0.916361621900696 0.0418632075471698 0.0328377009380096 0.05251395228803 NA NA NA 0 0 0.00226750498184259 NA NA NA NA 1576 1798 False True 0.187951392286167 0.145692196491888 0.239103427666056 0 0 0.000937967224503816 0.912328028055031 0.908164543099672 0.916361621900696 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 34 762 1708 5878 0.0195177956371986 0.0135535738415647 0.0271681688076995 0.885240963855421 0.877329592844544 0.892812209551861 0.0427135678391959 0.0297587534953938 0.0591790041093638 NA NA NA 0 0 0.0048293501600118 NA NA NA NA 776 886 False True 1 1 1 0 0 0 0 0.153555600631888 0.105123906971076 0.217595005784515 0 0 0.00215743487303753 0.885240963855421 0.877329592844544 0.892812209551861 3379 5) Not assoc w R New NotAwR yes 5 +Moxifloxacin glpK p.Val468Ile glpK_p.Val468Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin glpK p.Val99Ala glpK_p.Val99Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA c.1005C>T gyrA_c.1005C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1011G>C gyrA_c.1011G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1026C>T gyrA_c.1026C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1029C>G gyrA_c.1029C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1036C>T gyrA_c.1036C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1041G>T gyrA_c.1041G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1047C>A gyrA_c.1047C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1053G>C gyrA_c.1053G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 4001 18533 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999892096034529 0.999610268708724 0.999986932062044 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.31604598850287 0.0392471382871788 44.494064095996 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 1741 6639 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999849397590361 0.999161185884076 0.99999618708438 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.81332567489948 0.0485516368820753 298.645085154332 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1059G>A gyrA_c.1059G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 0 NA NA NA 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 4.63234191452137 0.0589984289392935 362.546724531758 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1068G>C gyrA_c.1068G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1074G>A gyrA_c.1074G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1081C>T gyrA_c.1081C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 4001 18533 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999892096034529 0.999610268708724 0.999986932062044 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.31604598850287 0.0392471382871788 44.494064095996 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 2 1741 6638 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999698795180722 0.998912372612698 0.9999635206173 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.90637564618035 0.032294587677361 36.6438813236649 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1086C>T gyrA_c.1086C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1092T>C gyrA_c.1092T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1098T>C gyrA_c.1098T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1113C>T gyrA_c.1113C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 3 27 3999 18508 0.000749625187406296 0.000154617422592445 0.00218914487959466 0.998543296466145 0.997881275222198 0.999039810553464 0.1 0.0211171370297225 0.265288450474208 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.514239671028868 0.0997947898714491 1.67243209522461 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 11 1742 6629 0 0 0.00211537106925253 0.998343373493976 0.997037775344334 0.999172737054126 0 0 0.284914152918154 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.51801526894139 NA NA NA NA NA NA 81 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.111C>T gyrA_c.111C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1122G>A gyrA_c.1122G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1134C>G gyrA_c.1134C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1143G>C gyrA_c.1143G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1167C>T gyrA_c.1167C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1182G>C gyrA_c.1182G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1185T>C gyrA_c.1185T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1194C>G gyrA_c.1194C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1200G>C gyrA_c.1200G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1206C>T gyrA_c.1206C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1209G>A gyrA_c.1209G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1212C>A gyrA_c.1212C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1212C>G gyrA_c.1212C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 4 4001 18531 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999784192069058 0.999447539013843 0.999941196572055 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.15789802549362 0.0235059760051305 11.7081385811536 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1218A>G gyrA_c.1218A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1224C>T gyrA_c.1224C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01683899052165 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1230G>A gyrA_c.1230G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1230G>T gyrA_c.1230G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1233G>A gyrA_c.1233G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 22 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1239C>G gyrA_c.1239C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.123G>A gyrA_c.123G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1242C>G gyrA_c.1242C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1245T>C gyrA_c.1245T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1260A>C gyrA_c.1260A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1261C>T gyrA_c.1261C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01683899052165 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.126G>A gyrA_c.126G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1278C>T gyrA_c.1278C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1293G>A gyrA_c.1293G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1302A>G gyrA_c.1302A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1308G>C gyrA_c.1308G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1318T>C gyrA_c.1318T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 4002 18530 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.05471226039473 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.22785363871091 NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1323G>T gyrA_c.1323G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 13 4002 18522 0 0 0.000921334294721226 0.99929862422444 0.998800924705247 0.999626495767062 0 0 0.24705263800047 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.51934003385999 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 1742 6636 0 0 0.00211537106925253 0.999397590361445 0.998458316867766 0.999835840034063 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 5.77543554850383 NA NA NA NA NA NA 73 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1326C>T gyrA_c.1326C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 11.2104345733627 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 20.3050873563561 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1329G>A gyrA_c.1329G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 5 4000 18530 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 0.999730240086323 0.999370583585258 0.99991240407437 0.285714285714285 0.0366925661760855 0.709579136262657 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.853 0.176375644908091 11.3239281818414 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 1742 6636 0 0 0.00211537106925253 0.999397590361445 0.998458316867766 0.999835840034063 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 5.77543554850383 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1335A>C gyrA_c.1335A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1344C>T gyrA_c.1344C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 9 4002 18526 0 0 0.000921334294721226 0.999514432155381 0.999078442003892 0.999777944189974 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.34636960420997 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1356C>T gyrA_c.1356C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1359C>T gyrA_c.1359C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.135C>T gyrA_c.135C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1365G>A gyrA_c.1365G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1368C>G gyrA_c.1368C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1371A>G gyrA_c.1371A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1389C>T gyrA_c.1389C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1393C>T gyrA_c.1393C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 3 14 3999 18521 0.000749625187406296 0.000154617422592445 0.00218914487959466 0.999244672241704 0.998733012789936 0.999586995715357 0.176470588235294 0.0379850680706259 0.434317872844283 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.992444539706355 0.182781663597741 3.55815859863829 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 3 1741 6637 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999548192771084 0.998680200855815 0.999906816794257 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.27072563660731 0.0241917279459833 15.8348342618437 NA NA NA NA NA NA 11 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1404C>T gyrA_c.1404C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 20.3050873563561 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1410A>G gyrA_c.1410A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1416C>G gyrA_c.1416C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1422G>A gyrA_c.1422G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1422G>T gyrA_c.1422G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1434C>T gyrA_c.1434C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1440C>A gyrA_c.1440C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1440C>T gyrA_c.1440C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 23 4002 18512 0 0 0.000921334294721226 0.998759104397086 0.998138625560345 0.999213221110021 0 0 0.148185128915224 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.805145588581956 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 6 1742 6634 0 0 0.00211537106925253 0.999096385542168 0.998034257105878 0.999668319522948 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.23733664541029 NA NA NA NA NA NA 113 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.144C>T gyrA_c.144C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1455A>G gyrA_c.1455A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1461G>C gyrA_c.1461G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1494C>T gyrA_c.1494C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 6 4001 18529 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999676288103587 0.999295549654279 0.999881194471086 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.771848704490544 0.0167759984530013 6.36465776860659 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.22785363871091 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1497C>T gyrA_c.1497C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1503C>T gyrA_c.1503C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1509A>T gyrA_c.1509A>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.150C>T gyrA_c.150C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1528T>C gyrA_c.1528T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1542G>A gyrA_c.1542G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1548C>G gyrA_c.1548C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1551T>G gyrA_c.1551T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1554C>G gyrA_c.1554C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1557T>G gyrA_c.1557T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1566A>G gyrA_c.1566A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1569G>C gyrA_c.1569G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 4.63234191452137 0.0589984289392935 362.546724531758 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 1741 6639 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999849397590361 0.999161185884076 0.99999618708438 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.81332567489948 0.0485516368820753 298.645085154332 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1572A>C gyrA_c.1572A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 4.63234191452137 0.0589984289392935 362.546724531758 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 1741 6639 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999849397590361 0.999161185884076 0.99999618708438 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.81332567489948 0.0485516368820753 298.645085154332 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1572A>G gyrA_c.1572A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1578C>T gyrA_c.1578C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 11.2104345733627 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1584C>T gyrA_c.1584C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1596T>C gyrA_c.1596T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 4001 18533 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999892096034529 0.999610268708724 0.999986932062044 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.31604598850287 0.0392471382871788 44.494064095996 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 2 1741 6638 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999698795180722 0.998912372612698 0.9999635206173 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.90637564618035 0.032294587677361 36.6438813236649 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.159C>G gyrA_c.159C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.159C>T gyrA_c.159C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.15G>T gyrA_c.15G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1602T>C gyrA_c.1602T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 4.63234191452137 0.0589984289392935 362.546724531758 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 1741 6639 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999849397590361 0.999161185884076 0.99999618708438 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.81332567489948 0.0485516368820753 298.645085154332 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1605C>G gyrA_c.1605C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1614A>G gyrA_c.1614A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 4.63234191452137 0.0589984289392935 362.546724531758 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 1741 6639 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999849397590361 0.999161185884076 0.99999618708438 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.81332567489948 0.0485516368820753 298.645085154332 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1623C>G gyrA_c.1623C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1629C>T gyrA_c.1629C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 14 4002 18521 0 0 0.000921334294721226 0.999244672241704 0.998733012789936 0.999586995715357 0 0 0.231635761650116 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.39588267491558 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 8 1742 6632 0 0 0.00211537106925253 0.998795180722891 0.997627413333175 0.999479705585957 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.23276380149116 NA NA NA NA NA NA 47 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.162G>A gyrA_c.162G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1632G>A gyrA_c.1632G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1641G>T gyrA_c.1641G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 20.3050873563561 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1644G>A gyrA_c.1644G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1645_1647delTTGinsCTC gyrA_c.1645_1647delTTGinsCTC 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1647G>A gyrA_c.1647G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 11 56 3991 18479 0.00274862568715642 0.00137287782368726 0.00491271640366202 0.996978688966819 0.996078346752294 0.997716951542235 0.164179104477611 0.0849125461284888 0.274800816041754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.909497261695958 0.429246894670719 1.75647056907396 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 7 27 1735 6613 0.00401836969001148 0.00161707270669399 0.00826174702450177 0.995933734939759 0.994089272018054 0.997318647254181 0.205882352941176 0.087021305458127 0.378977748539683 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.98817376454264 0.362676244971023 2.33098802205728 NA NA NA NA NA NA 79 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1656C>T gyrA_c.1656C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 4002 18530 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.05471226039473 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.22785363871091 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.165G>T gyrA_c.165G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1665C>G gyrA_c.1665C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1677C>T gyrA_c.1677C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 25 4002 18510 0 0 0.000921334294721226 0.998651200431615 0.998009545263528 0.999126943780254 0 0 0.137185171530712 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.73578035031414 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 15 1742 6625 0 0 0.00211537106925253 0.997740963855421 0.996276796314206 0.998735100547745 0 0 0.218019360910534 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.06165344268229 NA NA NA NA NA NA 32 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1680G>C gyrA_c.1680G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1689C>T gyrA_c.1689C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.168C>G gyrA_c.168C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1692C>T gyrA_c.1692C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1704G>A gyrA_c.1704G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 11.2104345733627 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1716C>G gyrA_c.1716C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 4.63234191452137 0.0589984289392935 362.546724531758 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1722A>C gyrA_c.1722A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1734G>A gyrA_c.1734G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1740G>A gyrA_c.1740G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01683899052165 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1746C>T gyrA_c.1746C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 126 3999 18409 0.000749625187406296 0.000154617422592445 0.00218914487959466 0.993202050175344 0.991911425383734 0.994334058659552 0.0232558139534883 0.00482182699708298 0.0664588228261984 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.109604782147917 0.0222705628273984 0.328001258104558 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 0 59 1742 6581 0 0 0.00211537106925253 0.991114457831325 0.98855308051117 0.993229228332718 0 0 0.0606089009503398 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 0 0 0 0.244094440884201 NA NA NA NA NA NA 187 5) Not assoc w R Now listed Silent mutation no 0 +Moxifloxacin gyrA c.174A>G gyrA_c.174A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1755C>G gyrA_c.1755C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1755C>T gyrA_c.1755C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1785C>T gyrA_c.1785C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1788G>A gyrA_c.1788G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 7 4001 18528 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999622336120852 0.999222023868969 0.999848146482689 0.125 0.0031597235312519 0.526509670875206 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.661548898489663 0.0146783588023133 5.15155114398686 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 4 1741 6636 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999397590361445 0.998458316867766 0.999835840034063 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.952900631820792 0.0193382014380594 9.63481227974485 NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1791C>T gyrA_c.1791C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1797G>C gyrA_c.1797G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1800A>G gyrA_c.1800A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1803C>G gyrA_c.1803C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1809G>A gyrA_c.1809G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1821C>G gyrA_c.1821C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1821C>T gyrA_c.1821C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 3 6 3999 18529 0.000749625187406296 0.000154617422592445 0.00218914487959466 0.999676288103587 0.999295549654279 0.999881194471086 0.333333333333333 0.0748546314196918 0.700704943791459 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.31670417604401 0.374722402274001 10.8496491446151 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 3 5 1739 6635 0.00172215843857634 0.000355291378803123 0.00502455256196275 0.999246987951807 0.99824360331506 0.999755455269461 0.375 0.0852334141372535 0.755136783633448 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.28924669350201 0.355118546302015 11.7805184875551 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1824C>T gyrA_c.1824C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 3 11 3999 18524 0.000749625187406296 0.000154617422592445 0.00218914487959466 0.99940652818991 0.998938363693644 0.999703704968061 0.214285714285714 0.0465792878898673 0.507975677048471 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.26331582895723 0.226188608253928 4.78526100700425 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 2 5 1740 6635 0.00114810562571756 0.000139071172424607 0.00414113746933503 0.999246987951807 0.99824360331506 0.999755455269461 0.285714285714285 0.0366925661760855 0.709579136262657 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.52528735632183 0.145099222357561 9.32605000579631 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1827C>A gyrA_c.1827C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 5 1 3997 18534 0.00124937531234382 0.000405789275012681 0.0029131967931525 0.999946048017264 0.999699435860871 0.999998634054993 0.833333333333333 0.358765421002325 0.99578925548551 NA NA NA NA NA NA NA NA NA NA NA NA False False 23.1848886664998 2.59300776862752 1089.88528001552 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 1740 6640 0.00114810562571756 0.000139071172424607 0.00414113746933503 1 0.999444600156968 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.716065670156237 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1836C>T gyrA_c.1836C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1842T>C gyrA_c.1842T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 71 1610 3931 16925 0.0177411294352823 0.0138813015086007 0.0223259954829269 0.913137307796061 0.908990727599209 0.917153737213387 0.0422367638310529 0.0331320185520501 0.0529799122844659 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.189870767636133 0.147176245421316 0.241555492785102 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 34 747 1708 5893 0.0195177956371986 0.0135535738415647 0.0271681688076995 0.8875 0.879653730522031 0.895004111801834 0.0435339308578745 0.0303338511892669 0.0603055943127186 NA NA NA NA NA NA NA NA NA NA NA NA False True 1 1 1 0 0 0 0 0.15703877179287 0.107493961618633 0.222527031403784 NA NA NA NA NA NA 3375 5) Not assoc w R Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1848C>T gyrA_c.1848C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1851C>T gyrA_c.1851C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1857C>T gyrA_c.1857C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 11.2104345733627 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 20.3050873563561 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1863G>A gyrA_c.1863G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.186C>G gyrA_c.186C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1881T>C gyrA_c.1881T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1884C>G gyrA_c.1884C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1899A>G gyrA_c.1899A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1905C>G gyrA_c.1905C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1917C>T gyrA_c.1917C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01683899052165 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1920C>T gyrA_c.1920C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1926C>G gyrA_c.1926C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.192C>T gyrA_c.192C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1932C>A gyrA_c.1932C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1938C>T gyrA_c.1938C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1947G>A gyrA_c.1947G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1959G>C gyrA_c.1959G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 153 4000 18382 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 0.991745346641489 0.990335676960258 0.992997283780775 0.0129032258064516 0.00156647825822792 0.0458318896003843 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.0600718954248366 0.00721104972309413 0.220891486943368 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 1 95 1741 6545 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.985692771084337 0.982538053709151 0.98840958979605 0.0104166666666666 0.000263692393550768 0.0566747069883146 NA NA NA NA NA NA NA NA NA NA NA NA False True 1 1 1 0 0 0 0 0.039571933855316 0.00099530137678182 0.226250194970206 NA NA NA NA NA NA 829 5) Not assoc w R Now listed Silent mutation no 0 +Moxifloxacin gyrA c.195C>G gyrA_c.195C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 11.2104345733627 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.22785363871091 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1962C>G gyrA_c.1962C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1962C>T gyrA_c.1962C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1971C>T gyrA_c.1971C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1977G>C gyrA_c.1977G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1989G>A gyrA_c.1989G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1989G>C gyrA_c.1989G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1992G>A gyrA_c.1992G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1995T>C gyrA_c.1995T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1998G>A gyrA_c.1998G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.1998G>C gyrA_c.1998G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 3 4001 18532 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999838144051794 0.999527061819887 0.99996662016845 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.5439473464967 0.0294026895471131 19.2327580431529 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.-19G>T gyrA_c.-19G>T 1 upstream_gene_variant 7283 1 4 0 4 19 7 3983 18528 0.00474762618690654 0.00286072826565278 0.00740411988297862 0.999622336120852 0.999222023868969 0.999848146482689 0.73076923076923 0.522125210306168 0.884267786708496 0 0 0.602364635616474 0 0 0.409616397225003 0 0 7.04917830130203 1 732.5 1798 False False 12.6262329184749 5.07780778692202 35.5228088709746 0 0 0.000925727276522252 0.999622336120852 0.999222023868969 0.999848146482689 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 7 4 1735 6636 0.00401836969001148 0.00161707270669399 0.00826174702450177 0.999397590361445 0.998458316867766 0.999835840034063 0.636363636363636 0.307904715011677 0.890736556180901 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.79874963960239 0.586915039661516 84 886 False False 0 0 0 0 0 0 0 6.69337175792507 1.6987522731748 31.2075607006942 0 0 0.00212389663781701 0.999397590361445 0.998458316867766 0.999835840034063 6 3) Uncertain significance No change no 1 +Moxifloxacin gyrA c.2007C>T gyrA_c.2007C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 2 4000 18533 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 0.999892096034529 0.999610268708724 0.999986932062044 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 4.63325 0.335715582549978 63.989229087488 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2014C>T gyrA_c.2014C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 5 4000 18530 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 0.999730240086323 0.999370583585258 0.99991240407437 0.285714285714285 0.0366925661760855 0.709579136262657 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.853 0.176375644908091 11.3239281818414 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 2 4 1740 6636 0.00114810562571756 0.000139071172424607 0.00414113746933503 0.999397590361445 0.998458316867766 0.999835840034063 0.333333333333333 0.0432718682927417 0.777221904496487 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.90689655172413 0.172334634649247 13.3169802580519 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2016G>A gyrA_c.2016G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2022C>G gyrA_c.2022C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 0 4000 18535 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 1 0.999800997443015 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.869940791113183 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2043C>T gyrA_c.2043C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.204C>G gyrA_c.204C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 1 4000 18534 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 0.999946048017264 0.999699435860871 0.999998634054993 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 9.267 0.482236652039982 544.73752523911 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2055G>T gyrA_c.2055G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2061C>T gyrA_c.2061C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2067G>C gyrA_c.2067G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2076A>G gyrA_c.2076A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2082T>G gyrA_c.2082T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2085T>C gyrA_c.2085T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2094G>A gyrA_c.2094G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01683899052165 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 20.3050873563561 NA NA NA NA NA NA 13 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2094G>C gyrA_c.2094G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2106C>A gyrA_c.2106C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 20.3050873563561 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2106C>T gyrA_c.2106C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2115C>T gyrA_c.2115C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2128C>A gyrA_c.2128C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2136G>A gyrA_c.2136G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2139G>A gyrA_c.2139G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2140C>T gyrA_c.2140C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2142G>A gyrA_c.2142G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 103 3999 18432 0.000749625187406296 0.000154617422592445 0.00218914487959466 0.994442945778257 0.99326444413097 0.99546195472601 0.0283018867924528 0.00587499548869049 0.0804865192942161 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.134247154021515 0.0272284250101484 0.403802880178104 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 0 51 1742 6589 0 0 0.00211537106925253 0.992319277108433 0.98991348996587 0.994276004558083 0 0 0.0697770307495386 NA NA NA NA NA NA NA NA NA NA NA NA False True 1 1 1 0 0 0 0 0 0 0.284130677417295 NA NA NA NA NA NA 152 5) Not assoc w R Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2142G>C gyrA_c.2142G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2163C>A gyrA_c.2163C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2166T>C gyrA_c.2166T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2170C>T gyrA_c.2170C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2172G>A gyrA_c.2172G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2172G>C gyrA_c.2172G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2181G>A gyrA_c.2181G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2196G>A gyrA_c.2196G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2199A>G gyrA_c.2199A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.21G>C gyrA_c.21G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2214G>A gyrA_c.2214G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2223G>A gyrA_c.2223G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 18 4002 18517 0 0 0.000921334294721226 0.999028864310763 0.998465619515959 0.999424345094191 0 0 0.185301968137852 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.05295108465467 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 16 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.222C>G gyrA_c.222C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2235C>G gyrA_c.2235C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2238C>T gyrA_c.2238C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2247T>C gyrA_c.2247T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2251C>T gyrA_c.2251C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2256G>C gyrA_c.2256G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 11 4001 18524 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.99940652818991 0.998938363693644 0.999703704968061 0.0833333333333333 0.00210759323186022 0.384796165150944 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.420894776305923 0.00977937778460056 2.89742168554269 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 2 1741 6638 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999698795180722 0.998912372612698 0.9999635206173 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.90637564618035 0.032294587677361 36.6438813236649 NA NA NA NA NA NA 36 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2256G>T gyrA_c.2256G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2259C>G gyrA_c.2259C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.225G>C gyrA_c.225G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.225G>T gyrA_c.225G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2265C>T gyrA_c.2265C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 4 4001 18531 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999784192069058 0.999447539013843 0.999941196572055 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.15789802549362 0.0235059760051305 11.7081385811536 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 1741 6639 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999849397590361 0.999161185884076 0.99999618708438 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.81332567489948 0.0485516368820753 298.645085154332 NA NA NA NA NA NA 74 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2280C>T gyrA_c.2280C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2286G>A gyrA_c.2286G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2295G>T gyrA_c.2295G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 25 4002 18510 0 0 0.000921334294721226 0.998651200431615 0.998009545263528 0.999126943780254 0 0 0.137185171530712 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.73578035031414 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 7 1742 6633 0 0 0.00211537106925253 0.99894578313253 0.997829124235982 0.999576048424705 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.64457250939033 NA NA NA NA NA NA 262 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2298G>A gyrA_c.2298G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.-22T>G gyrA_c.-22T>G 1 upstream_gene_variant 7280 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA c.2307C>T gyrA_c.2307C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2319G>A gyrA_c.2319G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 33 4001 18502 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.998219584569732 0.997500535018014 0.9987741368015 0.0294117647058823 0.00074436423469026 0.153267669560317 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.140131633758227 0.00344764129524963 0.837620004031413 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.231T>C gyrA_c.231T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 6 4002 18529 0 0 0.000921334294721226 0.999676288103587 0.999295549654279 0.999881194471086 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.93385874811763 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 1742 6636 0 0 0.00211537106925253 0.999397590361445 0.998458316867766 0.999835840034063 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 5.77543554850383 NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.231T>G gyrA_c.231T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2322G>A gyrA_c.2322G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 4001 18533 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999892096034529 0.999610268708724 0.999986932062044 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.31604598850287 0.0392471382871788 44.494064095996 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2322G>T gyrA_c.2322G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2328C>G gyrA_c.2328C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2328C>T gyrA_c.2328C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 6 4001 18529 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999676288103587 0.999295549654279 0.999881194471086 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.771848704490544 0.0167759984530013 6.36465776860659 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2352C>T gyrA_c.2352C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2355C>G gyrA_c.2355C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01683899052165 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 20 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2355C>T gyrA_c.2355C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2358C>T gyrA_c.2358C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2382G>A gyrA_c.2382G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2391G>A gyrA_c.2391G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 4.63234191452137 0.0589984289392935 362.546724531758 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2397G>A gyrA_c.2397G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 1 4000 18534 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 0.999946048017264 0.999699435860871 0.999998634054993 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 9.267 0.482236652039982 544.73752523911 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2400T>C gyrA_c.2400T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2403T>G gyrA_c.2403T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2406G>C gyrA_c.2406G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.240C>G gyrA_c.240C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2415T>C gyrA_c.2415T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2434C>T gyrA_c.2434C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 20.3050873563561 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2439G>A gyrA_c.2439G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2451C>G gyrA_c.2451C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2457C>T gyrA_c.2457C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 8 11 3994 18524 0.00199900049975012 0.000863409206250761 0.003935008292197 0.99940652818991 0.998938363693644 0.999703704968061 0.421052631578947 0.202521438977162 0.665002155988264 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.37305958938407 1.17692244655843 9.21173618652121 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 2 4 1740 6636 0.00114810562571756 0.000139071172424607 0.00414113746933503 0.999397590361445 0.998458316867766 0.999835840034063 0.333333333333333 0.0432718682927417 0.777221904496487 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.90689655172413 0.172334634649247 13.3169802580519 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2469C>T gyrA_c.2469C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.246C>T gyrA_c.246C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 4.63234191452137 0.0589984289392935 362.546724531758 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 1741 6639 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999849397590361 0.999161185884076 0.99999618708438 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.81332567489948 0.0485516368820753 298.645085154332 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2472C>T gyrA_c.2472C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 20.3050873563561 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2475T>C gyrA_c.2475T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2481C>T gyrA_c.2481C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.2487C>T gyrA_c.2487C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 5 5 3997 18530 0.00124937531234382 0.000405789275012681 0.0029131967931525 0.999730240086323 0.999370583585258 0.99991240407437 0.5 0.187086028447398 0.812913971552601 NA NA NA NA NA NA NA NA NA NA NA NA False False 4.63597698273705 1.06631671873539 20.1518372164177 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 3 4 1739 6636 0.00172215843857634 0.000355291378803123 0.00502455256196275 0.999397590361445 0.998458316867766 0.999835840034063 0.428571428571428 0.0989882784425078 0.815948432359917 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.86198964922369 0.41878325287878 16.9296564860373 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.249C>T gyrA_c.249C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.-24C>G gyrA_c.-24C>G 1 upstream_gene_variant 7278 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA c.2511C>T gyrA_c.2511C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.252C>T gyrA_c.252C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.255C>T gyrA_c.255C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.258G>C gyrA_c.258G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.-25G>A gyrA_c.-25G>A 1 upstream_gene_variant 7277 1 3 0 3 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 11.2104345733627 1 732.5 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA c.-25G>C gyrA_c.-25G>C 1 upstream_gene_variant 7277 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA c.264C>T gyrA_c.264C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 4001 18533 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999892096034529 0.999610268708724 0.999986932062044 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.31604598850287 0.0392471382871788 44.494064095996 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 1741 6639 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999849397590361 0.999161185884076 0.99999618708438 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.81332567489948 0.0485516368820753 298.645085154332 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.270G>C gyrA_c.270G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.273G>C gyrA_c.273G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.279C>T gyrA_c.279C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.-27C>G gyrA_c.-27C>G 1 upstream_gene_variant 7275 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA c.286C>T gyrA_c.286C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.288G>C gyrA_c.288G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.291G>C gyrA_c.291G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 11.2104345733627 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.294C>T gyrA_c.294C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.300C>G gyrA_c.300C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.306C>G gyrA_c.306C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 20.3050873563561 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.306C>T gyrA_c.306C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.-30A>G gyrA_c.-30A>G 1 upstream_gene_variant 7272 0 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1318 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 638 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA c.312G>A gyrA_c.312G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01683899052165 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.312G>T gyrA_c.312G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.315G>A gyrA_c.315G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 20.3050873563561 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.-32C>T gyrA_c.-32C>T 1 upstream_gene_variant 7270 1 3 0 3 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 11.2104345733627 1 732.5 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 21 3) Uncertain significance No change no 1 +Moxifloxacin gyrA c.333C>T gyrA_c.333C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 30 4002 18505 0 0 0.000921334294721226 0.998381440517939 0.997690205325877 0.998907706532097 0 0 0.115703308222027 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.605347923273691 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 62 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.342C>A gyrA_c.342C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.-34C>T gyrA_c.-34C>T 1 upstream_gene_variant 7268 0 0 0 0 26 363 3976 18172 0.0064967516241879 0.004248154141353 0.00950485283781854 0.980415430267062 0.978316534221418 0.982361629195174 0.0668380462724935 0.0441219941582245 0.0964018786841445 NA NA NA 0 0 0.0101107416401798 NA NA NA NA NA NA False True 0.327358087921468 0.210650478868008 0.488483108532253 0 0 0.000927356322128538 0.980415430267062 0.978316534221418 0.982361629195174 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 13 171 1729 6469 0.00746268656716417 0.0039793748824478 0.0127276127095834 0.974246987951807 0.970147155311624 0.977922755684862 0.0706521739130434 0.0381533235504087 0.117787142357554 NA NA NA 0 0 0.0213413745665028 NA NA NA NA NA NA False True 0 1 1 0 0 1 0 0.284439168095677 0.148049226215069 0.501201748944812 0 0 0.00213125915399026 0.974246987951807 0.970147155311624 0.977922755684862 429 Not assoc w R 5) Not assoc w R No change yes 1 +Moxifloxacin gyrA c.357A>C gyrA_c.357A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.372G>C gyrA_c.372G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.372G>T gyrA_c.372G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.384G>A gyrA_c.384G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 10 4001 18525 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999460480172646 0.999008028394192 0.999741249920483 0.0909090909090909 0.00229897221381426 0.412779916988382 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.463009247688078 0.0106697037948228 3.25640205836453 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 6 1742 6634 0 0 0.00211537106925253 0.999096385542168 0.998034257105878 0.999668319522948 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.23733664541029 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.390C>G gyrA_c.390C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 10 4002 18525 0 0 0.000921334294721226 0.999460480172646 0.999008028394192 0.999741249920483 0 0 0.30849710781876 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.06609723386524 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.390C>T gyrA_c.390C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.396C>T gyrA_c.396C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.399G>A gyrA_c.399G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.402G>A gyrA_c.402G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.408G>A gyrA_c.408G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.420G>A gyrA_c.420G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.438C>T gyrA_c.438C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.444G>A gyrA_c.444G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.462T>C gyrA_c.462T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.474C>T gyrA_c.474C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 13 4002 18522 0 0 0.000921334294721226 0.99929862422444 0.998800924705247 0.999626495767062 0 0 0.24705263800047 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.51934003385999 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 6 1742 6634 0 0 0.00211537106925253 0.999096385542168 0.998034257105878 0.999668319522948 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.23733664541029 NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.498A>G gyrA_c.498A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.507G>T gyrA_c.507G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.513C>G gyrA_c.513C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.519G>A gyrA_c.519G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.520C>T gyrA_c.520C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01683899052165 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.528C>T gyrA_c.528C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.531G>A gyrA_c.531G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.534A>G gyrA_c.534A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 12 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.537C>A gyrA_c.537C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.540C>T gyrA_c.540C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.549C>G gyrA_c.549C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.552C>T gyrA_c.552C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 11.2104345733627 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.561C>T gyrA_c.561C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.570G>A gyrA_c.570G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.582G>A gyrA_c.582G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.591G>A gyrA_c.591G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 20 291 3982 18244 0.00499750124937531 0.00305519555741204 0.00770773291663673 0.984299973024008 0.982405408402747 0.986040299902337 0.0643086816720257 0.0397204742018597 0.0975745145941123 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.314887785412362 0.18926697708628 0.496178413042816 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 5 24 1737 6616 0.00287026406429391 0.000932603401686605 0.00668542657812442 0.996385542168674 0.99462671677173 0.99768281759926 0.172413793103448 0.0584560829726344 0.357747554414644 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.79351372097486 0.236132632997032 2.12572172487096 NA NA NA NA NA NA 298 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.594C>T gyrA_c.594C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.597C>T gyrA_c.597C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.612G>A gyrA_c.612G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.613C>T gyrA_c.613C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.615G>A gyrA_c.615G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.624C>T gyrA_c.624C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.636A>G gyrA_c.636A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.651C>G gyrA_c.651C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 20.3050873563561 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.654G>C gyrA_c.654G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.657C>T gyrA_c.657C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 4 4001 18531 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999784192069058 0.999447539013843 0.999941196572055 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.15789802549362 0.0235059760051305 11.7081385811536 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 1741 6639 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999849397590361 0.999161185884076 0.99999618708438 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.81332567489948 0.0485516368820753 298.645085154332 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.669T>C gyrA_c.669T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.66G>A gyrA_c.66G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.681C>T gyrA_c.681C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.687G>C gyrA_c.687G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.6A>C gyrA_c.6A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.717C>T gyrA_c.717C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 6 4002 18529 0 0 0.000921334294721226 0.999676288103587 0.999295549654279 0.999881194471086 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.93385874811763 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 20.3050873563561 NA NA NA NA NA NA 14 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.729C>T gyrA_c.729C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.732C>T gyrA_c.732C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.735A>G gyrA_c.735A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.738T>C gyrA_c.738T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.741C>T gyrA_c.741C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 7 4002 18528 0 0 0.000921334294721226 0.999622336120852 0.999222023868969 0.999848146482689 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.21342445526953 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.744C>A gyrA_c.744C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.744C>T gyrA_c.744C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.750C>T gyrA_c.750C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.753T>C gyrA_c.753T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.780A>G gyrA_c.780A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.78C>G gyrA_c.78C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 11.2104345733627 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.805C>T gyrA_c.805C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01683899052165 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.22785363871091 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.825G>C gyrA_c.825G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01683899052165 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.834C>T gyrA_c.834C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 114 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.840C>T gyrA_c.840C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.861C>T gyrA_c.861C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.879C>T gyrA_c.879C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 11.2104345733627 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.882C>G gyrA_c.882C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.882C>T gyrA_c.882C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.886C>T gyrA_c.886C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.888G>A gyrA_c.888G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.888G>C gyrA_c.888G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 4002 18530 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.05471226039473 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.891C>T gyrA_c.891C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.894C>T gyrA_c.894C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.897T>C gyrA_c.897T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.-8A>G gyrA_c.-8A>G 1 upstream_gene_variant 7294 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrA c.900C>G gyrA_c.900C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.90C>T gyrA_c.90C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.918T>C gyrA_c.918T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.930C>T gyrA_c.930C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.933T>G gyrA_c.933T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 12 4002 18523 0 0 0.000921334294721226 0.999352576207175 0.998869354319296 0.999665423355947 0 0 0.264648469397051 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.66656583988199 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.22785363871091 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.945C>G gyrA_c.945C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.966G>C gyrA_c.966G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.984C>T gyrA_c.984C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 35 4002 18500 0 0 0.000921334294721226 0.998111680604262 0.997374773935693 0.99868437475483 0 0 0.100032435572105 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.514109561798401 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 9 1742 6631 0 0 0.00211537106925253 0.998644578313253 0.997428553721748 0.999380033497835 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.93068643684555 NA NA NA NA NA NA 209 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.987T>C gyrA_c.987T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.990C>T gyrA_c.990C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.993T>C gyrA_c.993T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.996C>T gyrA_c.996C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01683899052165 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 20.3050873563561 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.999G>A gyrA_c.999G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA c.9C>T gyrA_c.9C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrA p.Ala126Glu gyrA_p.Ala126Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 4001 18532 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999838144051794 0.999527061819887 0.99996662016845 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 11.2132358700375 1 732.5 1798 False False 1.5439473464967 0.0294026895471131 19.2327580431529 0 0 0.000921564464586207 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 1741 6638 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999698795180722 0.998912372612698 0.9999635206173 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3167233028695 1 345 886 False False 0 0 0 0 0 0 0 1.90637564618035 0.032294587677361 36.6438813236649 0 0 0.00211658481469046 0.999698795180722 0.998912372612698 0.9999635206173 5 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Ala126Ser gyrA_p.Ala126Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Ala126Val gyrA_p.Ala126Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1281 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Ala186Thr gyrA_p.Ala186Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Ala198Gly gyrA_p.Ala198Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Ala210Val gyrA_p.Ala210Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 4002 18530 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 5.05471226039473 0.593754047365944 137.5 1798 False False 0 0 5.05471226039473 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Ala217Val gyrA_p.Ala217Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Ala288Asp gyrA_p.Ala288Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 13 6 7 12 9 3990 18526 0.00299850074962518 0.00155029923838043 0.00523191326268615 0.999514432155381 0.999078442003892 0.999777944189974 0.571428571428571 0.340206309280274 0.781803143114869 0.461538461538461 0.192232441801288 0.748654517729696 0.4 0.163364323859513 0.677130233793718 3.9798066595059 1.10422157998805 13.8374848940152 0.0170669908092453 32 1798 False False 6.19081035923141 2.39197010755118 16.642908100707 0.0015015015015015 0.000551217628863946 0.00326525055803608 0.999514432155381 0.999078442003892 0.999777944189974 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 3 3 1739 6637 0.00172215843857634 0.000355291378803123 0.00502455256196275 0.999548192771084 0.998680200855815 0.999906816794257 0.5 0.118117248757025 0.881882751242974 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.24377553763589 1 345 886 False False 0 0 0 0 0 0 0 3.81656124209315 0.510625108255601 28.5261585470587 0 0 0.00211901648886052 0.999548192771084 0.998680200855815 0.999906816794257 25 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Ala288Val gyrA_p.Ala288Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 4002 18529 0 0 0.000921334294721226 0.999676288103587 0.999295549654279 0.999881194471086 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.93385874811763 0.599069212767884 166.5 1798 False False 0 0 3.93385874811763 0 0 0.000921334294721226 0.999676288103587 0.999295549654279 0.999881194471086 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Ala297Gly gyrA_p.Ala297Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Ala322Glu gyrA_p.Ala322Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 24.660125576486 1 198.5 1798 False False 0 0 7.01683899052165 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 17 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Ala322Ser gyrA_p.Ala322Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Ala324Gly gyrA_p.Ala324Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Ala324Val gyrA_p.Ala324Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Ala347Ser gyrA_p.Ala347Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1309 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 635 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Ala347Thr gyrA_p.Ala347Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1310 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Ala347Val gyrA_p.Ala347Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Ala384Val gyrA_p.Ala384Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 69 1555 3933 16980 0.0172413793103448 0.0134389489653759 0.0217699828155818 0.916104666846506 0.912020983219587 0.92005724680138 0.042487684729064 0.0332057098620597 0.053465518907005 0 0 0.975 0 0 0.00236945813727548 0 0 167.945957323049 1 NA NA False True 0.191572178033508 0.147948646986275 0.244571882929277 0 0 0.000937490475244044 0.916104666846506 0.912020983219587 0.92005724680138 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 1 0 1 32 734 1710 5906 0.018369690011481 0.0125979326364575 0.0258342769769089 0.889457831325301 0.881668767798743 0.896902974438277 0.04177545691906 0.0287469113619809 0.0584651446037319 0 0 0.975 0 0 0.00501311351965345 0 0 134.440154522536 1 NA NA False True 1 1 1 0 0 1 0 0.150574437911308 0.101848987713692 0.215542419549681 0 0 0.00215491427811716 0.889457831325301 0.881668767798743 0.896902974438277 2968 Not assoc w R 5) Not assoc w R No change yes 1 +Moxifloxacin gyrA p.Ala400Val gyrA_p.Ala400Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Ala406Pro gyrA_p.Ala406Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Ala406Val gyrA_p.Ala406Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Ala410Val gyrA_p.Ala410Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Ala432Gly gyrA_p.Ala432Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1323 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Ala432Val gyrA_p.Ala432Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Ala445Val gyrA_p.Ala445Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 5 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Ala456Val gyrA_p.Ala456Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 15 0 15 0 18 4002 18517 0 0 0.000921334294721226 0.999028864310763 0.998465619515959 0.999424345094191 0 0 0.185301968137852 0 0 0.218019360910534 0 0 0.185301968137852 0 0 1.29068196829985 0.0896005305586502 46 1798 False False 0 0 1.05295108465467 0 0 0.000921334294721226 0.999028864310763 0.998465619515959 0.999424345094191 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 8 1742 6632 0 0 0.00211537106925253 0.998795180722891 0.997627413333175 0.999479705585957 0 0 0.369416647552819 0 0 0.409616397225003 0 0 0.369416647552819 0 0 2.64417397004802 0.357315769312497 67 886 False False 0 0 0 0 0 0 0 0 0 2.23276380149116 0 0 0.00211537106925253 0.998795180722891 0.997627413333175 0.999479705585957 40 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Ala463Ser gyrA_p.Ala463Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 64 155 3938 18380 0.015992003998001 0.0123370028574755 0.0203760962400777 0.991637442676018 0.990219398689893 0.992897815123078 0.292237442922374 0.232907336733431 0.357290774718281 NA NA NA 0 0 0.0235182541485328 NA NA NA NA NA NA False True 1.92716132308851 1.41409563514346 2.60041289895195 0 0 0.000936300719718888 0.991637442676018 0.990219398689893 0.992897815123078 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 25 46 1717 6594 0.0143513203214695 0.00930837733708019 0.0211129075359095 0.993072289156626 0.990770100282336 0.99492371048562 0.352112676056338 0.242412268442463 0.474575040420723 NA NA NA 0 0 0.0770618270519006 NA NA NA NA NA NA False True 0 1 1 0 0 1 0 2.08718442176698 1.22498758776707 3.47971194519623 0 0 0.00214613838893476 0.993072289156626 0.990770100282336 0.99492371048562 234 Not assoc w R 5) Not assoc w R No change yes 1 +Moxifloxacin gyrA p.Ala500Glu gyrA_p.Ala500Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Ala501Val gyrA_p.Ala501Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Ala512Gly gyrA_p.Ala512Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 180.16529327284 1 732.5 1798 False False 4.63234191452137 0.0589984289392935 362.546724531758 0 0 0.000921564464586207 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Ala512Thr gyrA_p.Ala512Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Ala579Val gyrA_p.Ala579Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 180.16529327284 1 732.5 1798 False False 4.63234191452137 0.0589984289392935 362.546724531758 0 0 0.000921564464586207 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 1741 6639 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999849397590361 0.999161185884076 0.99999618708438 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 148.399526333966 1 596 886 False False 0 0 0 0 0 0 0 3.81332567489948 0.0485516368820753 298.645085154332 0 0 0.00211658481469046 0.999849397590361 0.999161185884076 0.99999618708438 8 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Ala591Val gyrA_p.Ala591Val 1 missense_variant (see "Genomic_coordinates" sheet) 2 2 1 1 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 4.63234191452137 0.0589984289392935 362.546724531758 0.323623032303333 101.5 1798 False False 4.63234191452137 0.0589984289392935 362.546724531758 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Ala626Val gyrA_p.Ala626Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 24.6614555089698 1 732.5 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Ala662Val gyrA_p.Ala662Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Ala667Val gyrA_p.Ala667Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Ala676Asp gyrA_p.Ala676Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Ala676Val gyrA_p.Ala676Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 8 6 3994 18529 0.00199900049975012 0.000863409206250761 0.003935008292197 0.999676288103587 0.999295549654279 0.999881194471086 0.571428571428571 0.288609400038307 0.823388910017882 0 0 0.707598226178713 0 0 0.4592581264399 0 0 11.2310667031742 1 732.5 1798 False False 6.18561175095977 1.88070956380815 21.6379253942151 0 0 0.00092317887936968 0.999676288103587 0.999295549654279 0.999881194471086 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 6 2 1736 6638 0.00344431687715269 0.00126502019745104 0.00748164597286304 0.999698795180722 0.998912372612698 0.9999635206173 0.75 0.349144205587175 0.968145973750055 0 0 0.975 0 0 0.841886116991581 0 0 148.803588970429 1 345 886 False False 0 0 0 0 0 0 0 11.471198156682 2.04817072388066 116.349100429339 0 0 0.00212267449445866 0.999698795180722 0.998912372612698 0.9999635206173 3 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Ala689Val gyrA_p.Ala689Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.118754661339467 Inf 0.177574655011758 72.5 1798 False False Inf 0.118754661339467 Inf 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Ala696Thr gyrA_p.Ala696Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Ala696Val gyrA_p.Ala696Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Ala71Thr gyrA_p.Ala71Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Ala736Thr gyrA_p.Ala736Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 4.63234191452137 0.0589984289392935 362.546724531758 0.323623032303333 101.5 1798 False False 4.63234191452137 0.0589984289392935 362.546724531758 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Ala736Val gyrA_p.Ala736Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 4002 18530 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 7.01646036669751 1 198.5 1798 False False 0 0 5.05471226039473 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.302036906212 1 345 886 False False 0 0 0 0 0 0 0 0 0 9.22785363871091 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 8 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Ala74Ser gyrA_p.Ala74Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 5 1 3997 18534 0.00124937531234382 0.000405789275012681 0.0029131967931525 0.999946048017264 0.999699435860871 0.999998634054993 0.833333333333333 0.358765421002325 0.99578925548551 0 0 0.975 0 0 0.975 0 0 180.345085724119 1 198.5 1798 False False 23.1848886664998 2.59300776862752 1089.88528001552 0 0 0.00092248629522778 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 628 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 10 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Ala74Thr gyrA_p.Ala74Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1258 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 604 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Ala74Val gyrA_p.Ala74Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 3 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Ala787Gly gyrA_p.Ala787Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 4002 18530 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 5.05471226039473 0.593754047365944 137.5 1798 False False 0 0 5.05471226039473 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Ala814Thr gyrA_p.Ala814Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 180.101020147088 1 732.5 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 629 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 5 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Ala90Glu gyrA_p.Ala90Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 180.16529327284 1 732.5 1798 False False 4.63234191452137 0.0589984289392935 362.546724531758 0 0 0.000921564464586207 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Ala90Gly gyrA_p.Ala90Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA NA NA False True 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA NA NA False True 0 0 0 0 0 1 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 33 Not assoc w RI Literature evidence (PMID 28137812) 4) Not assoc w R - Interim No change yes Lit. (PMID 28137812) 1 +Moxifloxacin gyrA p.Ala90Val gyrA_p.Ala90Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 946 536 410 720 452 3282 18083 0.179910044977511 0.168121496489991 0.192167825576754 0.975613703803614 0.973290120069062 0.977786383439867 0.614334470989761 0.58578200198107 0.642311565505892 0.566596194503171 0.534323249440658 0.598453303048411 0.542510121457489 0.510851898584218 0.573914316674027 7.20299044306713 6.28681284696125 8.25488231454162 8.95754687126501e-176 2 1798 True False 8.77659316302923 7.74464517954669 9.94963558699646 0.140387637506547 0.129515948496606 0.151812881759601 0.975613703803614 0.973290120069062 0.977786383439867 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 400 239 161 333 170 1409 6470 0.191159586681974 0.172939638766428 0.210425919403337 0.974397590361445 0.97030852440499 0.978062426490465 0.662027833001988 0.618836335989864 0.7033015384621359 0.5975 0.547615775629573 0.6459305609376 0.584352078239608 0.53489991307563 0.632574816290558 6.81656079594796 5.50838982719237 8.44449723101116 1.66207486497079e-72 2 886 True False 0 0 0 0 0 0 0 8.99473969857637 7.38291334376275 10.9784740206365 0.14502427184466 0.128363879789998 0.162959628889543 0.974397590361445 0.97030852440499 0.978062426490465 776 Assoc w R Assoc w R Marker of R 1) Assoc w R Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance) No change yes F 1 +Moxifloxacin gyrA p.Arg106Cys gyrA_p.Arg106Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 180.110710654533 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 631 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 2 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Arg128Lys gyrA_p.Arg128Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.118754661339467 Inf 0.177574655011758 72.5 1798 False False Inf 0.118754661339467 Inf 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Arg14Leu gyrA_p.Arg14Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Arg195Gly gyrA_p.Arg195Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Arg252Gly gyrA_p.Arg252Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Arg252Leu gyrA_p.Arg252Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 69 0 69 2 73 4000 18462 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 0.996061505260318 0.995050445342889 0.996911616416985 0.0266666666666666 0.00324593092896602 0.0930315322207254 0 0 0.0520580578630797 0 0 0.0492770608958592 0 0 0.253619167257996 1.96516626872741e-06 16 1798 True False 0.12645205479452 0.0150048817368166 0.473811339822799 0 0 0.000921794749483055 0.996061505260318 0.995050445342889 0.996911616416985 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 24 0 24 0 26 1742 6614 0 0 0.00211537106925253 0.996084337349397 0.994267874481466 0.997440613016852 0 0 0.132274604497754 0 0 0.142473597722525 0 0 0.132274604497754 0 0 0.631662616815222 0.0050686147284638 15 886 False False 0 0 0 0 0 0 0 0 0 0.579568157474618 0 0 0.00211537106925253 0.996084337349397 0.994267874481466 0.997440613016852 104 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Arg254Cys gyrA_p.Arg254Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 12 0 12 0 12 4002 18523 0 0 0.000921334294721226 0.999352576207175 0.998869354319296 0.999665423355947 0 0 0.264648469397051 0 0 0.264648469397051 0 0 0.264648469397051 0 0 1.66656583988199 0.142106949470919 50.5 1798 False False 0 0 1.66656583988199 0 0 0.000921334294721226 0.999352576207175 0.998869354319296 0.999665423355947 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 7 1742 6633 0 0 0.00211537106925253 0.99894578313253 0.997829124235982 0.999576048424705 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 2.64457250939033 0.357314381934628 65 886 False False 0 0 0 0 0 0 0 0 0 2.64457250939033 0 0 0.00211537106925253 0.99894578313253 0.997829124235982 0.999576048424705 5 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Arg254Leu gyrA_p.Arg254Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1319 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Arg26Cys gyrA_p.Arg26Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Arg26His gyrA_p.Arg26His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Arg292Gly gyrA_p.Arg292Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 3 2 3999 18533 0.000749625187406296 0.000154617422592445 0.00218914487959466 0.999892096034529 0.999610268708724 0.999986932062044 0.6 0.146632799634673 0.947255049473683 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6812792139651 1 732.5 1798 False False 6.9516129032258 0.795983567419885 83.4550561301111 0 0 0.000922025149498025 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 1741 6638 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999698795180722 0.998912372612698 0.9999635206173 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3167233028695 1 345 886 False False 0 0 0 0 0 0 0 1.90637564618035 0.032294587677361 36.6438813236649 0 0 0.00211658481469046 0.999698795180722 0.998912372612698 0.9999635206173 7 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Arg292Leu gyrA_p.Arg292Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1272 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 614 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Arg309Gln gyrA_p.Arg309Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Arg309Trp gyrA_p.Arg309Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 4000 18535 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 1 0.999800997443015 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.118784342620711 Inf 0.177538161164359 60 1798 False False Inf 0.869940791113183 Inf 0.000249937515621094 6.32785000763801e-06 0.00139176737893813 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 1740 6640 0.00114810562571756 0.000139071172424607 0.00414113746933503 1 0.999444600156968 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0977922278804612 Inf 0.207731774251282 32 886 False False 0 0 0 0 0 0 0 Inf 0.716065670156237 Inf 0.000574382538770821 1.45420010902056e-05 0.00319605610685329 1 0.999444600156968 1 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Arg375Gln gyrA_p.Arg375Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1273 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Arg380Gly gyrA_p.Arg380Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Arg387Gln gyrA_p.Arg387Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1305 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 633 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Arg392Cys gyrA_p.Arg392Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 4000 18535 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 1 0.999800997443015 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.118784342620711 Inf 0.177538161164359 60 1798 False False Inf 0.869940791113183 Inf 0.000249937515621094 6.32785000763801e-06 0.00139176737893813 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Arg392His gyrA_p.Arg392His 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 4 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Arg409Gln gyrA_p.Arg409Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 3 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Arg450Ser gyrA_p.Arg450Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 3999 18535 0.000749625187406296 0.000154617422592445 0.00218914487959466 1 0.999800997443015 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1268 1798 False False Inf 1.91440039171731 Inf 0 0 0.000922025149498025 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 611 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Arg480Cys gyrA_p.Arg480Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 180.110710654533 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Arg489Lys gyrA_p.Arg489Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Arg489Ser gyrA_p.Arg489Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Arg495Cys gyrA_p.Arg495Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 4 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Arg497Trp gyrA_p.Arg497Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Arg513Cys gyrA_p.Arg513Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Arg578Gln gyrA_p.Arg578Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 23 2 21 9 24 3993 18511 0.00224887556221889 0.00102882864885218 0.00426475484372027 0.998705152414351 0.99807397809504 0.999170196040018 0.272727272727272 0.132996388710814 0.455238427760781 0.0869565217391304 0.0107099660378758 0.280379335909411 0.0769230769230769 0.00945539100371274 0.251302916695373 0.4415107390314 0.0501722179462302 1.80751883308996 0.410308845755071 117 1798 False False 1.73844853493613 0.710547042067281 3.87769921401654 0.000500625782227784 6.06338559216711e-05 0.00180725030378026 0.998705152414351 0.99807397809504 0.999170196040018 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 14 0 14 3 15 1739 6625 0.00172215843857634 0.000355291378803123 0.00502455256196275 0.997740963855421 0.996276796314206 0.998735100547745 0.166666666666666 0.0357850831215746 0.414177491394774 0 0 0.231635761650116 0 0 0.218019360910534 0 0 1.14989309919038 0.0898391603242816 24 886 False False 0 0 0 0 0 0 0 0.761932144910868 0.14126069746047 2.69784156658111 0 0 0.00211901648886052 0.997740963855421 0.996276796314206 0.998735100547745 28 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Arg592Cys gyrA_p.Arg592Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1282 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 618 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Arg607Cys gyrA_p.Arg607Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Arg607His gyrA_p.Arg607His 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 4 4001 18531 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999784192069058 0.999447539013843 0.999941196572055 0.2 0.00505076337946806 0.716417936118089 0 0 0.841886116991581 0 0 0.602364635616474 0 0 24.6662864056643 1 732.5 1798 False False 1.15789802549362 0.0235059760051305 11.7081385811536 0 0 0.000921564464586207 0.999784192069058 0.999447539013843 0.999941196572055 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 632 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 12 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Arg615Gly gyrA_p.Arg615Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Arg615His gyrA_p.Arg615His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Arg615Leu gyrA_p.Arg615Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Arg65His gyrA_p.Arg65His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Arg68Cys gyrA_p.Arg68Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1311 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Arg68Gly gyrA_p.Arg68Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1284 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 620 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Arg68Ser gyrA_p.Arg68Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Arg718Cys gyrA_p.Arg718Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1299 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Arg789Gly gyrA_p.Arg789Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 7.01683899052165 1 732.5 1798 False False 0 0 7.01683899052165 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 16 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Arg789His gyrA_p.Arg789His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Asn193Ser gyrA_p.Asn193Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 40 0 40 3 40 3999 18495 0.000749625187406296 0.000154617422592445 0.00218914487959466 0.997841920690585 0.997062455780841 0.998457802661391 0.0697674418604651 0.0146254969951322 0.190607231885792 0 0 0.0880973028788023 0 0 0.0880973028788023 0 0 0.447063761931336 0.000630008391366461 23 1798 True False 0.346867966991747 0.0686092032039323 1.09003096945851 0 0 0.000922025149498025 0.997841920690585 0.997062455780841 0.998457802661391 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 12 0 12 0 12 1742 6628 0 0 0.00211537106925253 0.998192771084337 0.996845265024717 0.999065840721332 0 0 0.264648469397051 0 0 0.264648469397051 0 0 0.264648469397051 0 0 1.37098656231317 0.144212204250456 28.5 886 False False 0 0 0 0 0 0 0 0 0 1.37098656231317 0 0 0.00211537106925253 0.998192771084337 0.996845265024717 0.999065840721332 75 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Asn282Lys gyrA_p.Asn282Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 4 5 3998 18530 0.000999500249875062 0.000272395196018755 0.00255712257980299 0.999730240086323 0.999370583585258 0.99991240407437 0.444444444444444 0.136995662265166 0.787991493221131 0 0 0.521823750104981 0 0 0.521823750104981 0 0 5.0597709290087 0.593799712118616 153 1798 False False 3.70785392696348 0.735345863115156 17.2266045739096 0 0 0.000922255664717455 0.999730240086323 0.999370583585258 0.99991240407437 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 15 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Asn301Thr gyrA_p.Asn301Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1295 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Asn629Lys gyrA_p.Asn629Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Asn818Asp gyrA_p.Asn818Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 7 4002 18528 0 0 0.000921334294721226 0.999622336120852 0.999222023868969 0.999848146482689 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 3.21342445526953 0.615309777551834 178.5 1798 False False 0 0 3.21342445526953 0 0 0.000921334294721226 0.999622336120852 0.999222023868969 0.999848146482689 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Asn826Asp gyrA_p.Asn826Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 4002 18530 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 5.05471226039473 0.593754047365944 137.5 1798 False False 0 0 5.05471226039473 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 48 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Asn826His gyrA_p.Asn826His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Asn826Ile gyrA_p.Asn826Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1328 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Asn831Lys gyrA_p.Asn831Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Asp111Gly gyrA_p.Asp111Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1264 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Asp209Gly gyrA_p.Asp209Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Asp211Glu gyrA_p.Asp211Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Asp211Gly gyrA_p.Asp211Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Asp242Asn gyrA_p.Asp242Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Asp262Val gyrA_p.Asp262Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Asp293Tyr gyrA_p.Asp293Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 4002 18529 0 0 0.000921334294721226 0.999676288103587 0.999295549654279 0.999881194471086 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.93385874811763 0.599069212767884 166.5 1798 False False 0 0 3.93385874811763 0 0 0.000921334294721226 0.999676288103587 0.999295549654279 0.999881194471086 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.22785363871091 1 345 886 False False 0 0 0 0 0 0 0 0 0 9.22785363871091 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 4 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Asp308_Val310delinsLeu gyrA_p.Asp308_Val310delinsLeu 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Asp30Asn gyrA_p.Asp30Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Asp367Glu gyrA_p.Asp367Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Asp367His gyrA_p.Asp367His 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1277 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Asp415Asn gyrA_p.Asp415Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Asp415Phe gyrA_p.Asp415Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Asp437Gly gyrA_p.Asp437Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1283 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 619 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Asp464Glu gyrA_p.Asp464Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 6 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Asp467Glu gyrA_p.Asp467Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Asp467His gyrA_p.Asp467His 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Asp481Ala gyrA_p.Asp481Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Asp481Glu gyrA_p.Asp481Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1265 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 610 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Asp481Gly gyrA_p.Asp481Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Asp488Ala gyrA_p.Asp488Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 2 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Asp488Glu gyrA_p.Asp488Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 11.2104345733627 1 732.5 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 26 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Asp493His gyrA_p.Asp493His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Asp504Glu gyrA_p.Asp504Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1321 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 639 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 7 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Asp507His gyrA_p.Asp507His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Asp509Asn gyrA_p.Asp509Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Asp515Asn gyrA_p.Asp515Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Asp515Glu gyrA_p.Asp515Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1293 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Asp532Asn gyrA_p.Asp532Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Asp552Gly gyrA_p.Asp552Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1269 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 612 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Asp583Glu gyrA_p.Asp583Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Asp639Ala gyrA_p.Asp639Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 7 4002 18528 0 0 0.000921334294721226 0.999622336120852 0.999222023868969 0.999848146482689 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1289 1798 False False 0 0 3.21342445526953 0 0 0.000921334294721226 0.999622336120852 0.999222023868969 0.999848146482689 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 623 886 False False 0 0 0 0 0 0 0 0 0 9.22785363871091 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 112 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Asp639Gly gyrA_p.Asp639Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Asp641Glu gyrA_p.Asp641Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1290 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 624 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Asp641Tyr gyrA_p.Asp641Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Asp687Asn gyrA_p.Asp687Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Asp770Gly gyrA_p.Asp770Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1285 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Asp810Glu gyrA_p.Asp810Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1262 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 607 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Asp824Asn gyrA_p.Asp824Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1306 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Asp824Glu gyrA_p.Asp824Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1259 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 605 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Asp825Glu gyrA_p.Asp825Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1314 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Asp829Glu gyrA_p.Asp829Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 11.2104345733627 1 732.5 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 10 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Asp89Asn gyrA_p.Asp89Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 26 20 6 20 6 3982 18529 0.00499750124937531 0.00305519555741204 0.00770773291663673 0.999676288103587 0.999295549654279 0.999881194471086 0.769230769230769 0.563524903058613 0.910259889115424 0.769230769230769 0.563524903058613 0.910259889115424 0.769230769230769 0.563524903058613 0.910259889115424 15.5106311736145 6.00168636698896 47.2305304053259 7.12479139050002e-11 11 1798 True False 15.5106311736145 6.00168636698896 47.2305304053259 0.00499750124937531 0.00305519555741204 0.00770773291663673 0.999676288103587 0.999295549654279 0.999881194471086 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 13 12 1 12 1 1730 6639 0.00688863375430539 0.00356437432223058 0.0120021089527692 0.999849397590361 0.999161185884076 0.99999618708438 0.923076923076923 0.639702564732122 0.998054371502653 0.923076923076923 0.639702564732122 0.998054371502653 0.923076923076923 0.639702564732122 0.998054371502653 46.0508670520231 6.80127537621198 1948.47514556052 6.62735729416893e-08 9 886 True False 0 0 0 0 0 0 0 46.0508670520231 6.80127537621198 1948.47514556052 0.00688863375430539 0.00356437432223058 0.0120021089527692 0.999849397590361 0.999161185884076 0.99999618708438 18 1) Assoc w R Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance) UP from Uncertain to AwR yes F 4 +Moxifloxacin gyrA p.Asp89Gly gyrA_p.Asp89Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 0 3998 18535 0.000999500249875062 0.000272395196018755 0.00255712257980299 1 0.999800997443015 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 1263 1798 False False Inf 3.05877565622988 Inf 0 0 0.000922255664717455 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 1739 6640 0.00172215843857634 0.000355291378803123 0.00502455256196275 1 0.999444600156968 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 608 886 False False 0 0 0 0 0 0 0 Inf 1.57612016206794 Inf 0 0 0.00211901648886052 1 0.999444600156968 1 10 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Asp94Ala gyrA_p.Asp94Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 320 168 152 261 172 3741 18363 0.0652173913043478 0.0577623529508025 0.0733145834765975 0.990720258969517 0.989233157082689 0.99205018860303 0.602771362586605 0.554953430933624 0.649175105134017 0.525 0.468710113009275 0.580822921911304 0.494117647058823 0.439756612093301 0.548582007615776 5.42527328746887 4.31705603192206 6.82067149707201 8.65939428031936e-47 6 1798 True False 7.44848566792861 6.09873497848149 9.11274190948689 0.0429777436684574 0.0368360604293525 0.0498138047675171 0.990720258969517 0.989233157082689 0.99205018860303 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 153 92 61 143 67 1599 6573 0.0820895522388059 0.069624402467822 0.0959827168938087 0.989909638554216 0.987203077831896 0.992171792336762 0.680952380952381 0.613297761235963 0.743411001041417 0.601307189542483 0.519111983203561 0.679499192191924 0.578616352201257 0.497857831767331 0.656388536414055 6.19973549041921 4.41458766813304 8.75568284721022 1.86673901270028e-27 6 886 True False 0 0 0 0 0 0 0 8.7735711685475 6.48070408165387 11.9657174376653 0.0544056771141336 0.0440808616836928 0.0663089441187954 0.989909638554216 0.987203077831896 0.992171792336762 285 Assoc w R Assoc w R Marker of R 1) Assoc w R Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance) No change yes F 1 +Moxifloxacin gyrA p.Asp94Asn gyrA_p.Asp94Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 316 264 52 296 53 3706 18482 0.0739630184907546 0.066043067005985 0.0825114662352618 0.997140544915025 0.996261410160293 0.997857360572997 0.848137535816618 0.80611227159825 0.884129053397068 0.835443037974683 0.789870744170369 0.874592219655593 0.832807570977918 0.787082562215536 0.872182268740295 25.3188592303541 18.7025398932043 34.8603938661387 8.21166419812559e-147 3 1798 True False 27.8521927725564 20.6716239633683 38.1216733952253 0.0664987405541561 0.0589438217567566 0.074699012266389 0.997140544915025 0.996261410160293 0.997857360572997 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 115 98 17 112 17 1630 6623 0.0642939150401837 0.0532306936265486 0.0768509006423826 0.997439759036144 0.995903960705664 0.998507879902128 0.868217054263565 0.797405369801302 0.921319626078998 0.852173913043478 0.773897814586977 0.911463772832564 0.852173913043478 0.773897814586977 0.911463772832564 23.4230963551064 13.8513486899926 41.9213509050096 1.69520731993922e-50 3 886 True False 0 0 0 0 0 0 0 26.7692529772645 15.9316140589265 47.7281099988455 0.0567129629629629 0.0462789439422182 0.0686821107824372 0.997439759036144 0.995903960705664 0.998507879902128 202 Assoc w R Assoc w R Marker of R 1) Assoc w R High-level resistance No change yes G 1 +Moxifloxacin gyrA p.Asp94Gly gyrA_p.Asp94Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1775 1534 241 1692 260 2310 18275 0.422788605697151 0.407419561549347 0.438270494721114 0.985972484488804 0.984174072698311 0.987615955939952 0.866803278688524 0.850921874733836 0.881573465790736 0.864225352112676 0.847405482935314 0.879830819747659 0.855072463768116 0.837924223552658 0.871050191797823 50.3562896301485 43.5825797007702 58.1997225786778 0 1 1798 True False 51.4840159840159 44.7954142128655 59.2165929629757 0.399063475546305 0.383534338087134 0.414746241281194 0.985972484488804 0.984174072698311 0.987615955939952 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 770 709 61 773 68 969 6572 0.443742824339839 0.420236588423138 0.46743887557142 0.989759036144578 0.9870349647123 0.992038961546927 0.919143876337693 0.898619362965279 0.936667511704039 0.92077922077922 0.899398388394 0.93886311519262 0.912483912483912 0.890370466727702 0.931400908129405 78.8297551980239 59.9792917149527 104.927744044013 0 1 886 True False 0 0 0 0 0 0 0 77.0982213318764 59.4587657064966 101.385844281051 0.422526817640047 0.398747474827231 0.44657762786321 0.989759036144578 0.9870349647123 0.992038961546927 1140 Assoc w R Assoc w R Marker of R 1) Assoc w R High-level resistance No change yes G 1 +Moxifloxacin gyrA p.Asp94His gyrA_p.Asp94His 1 missense_variant (see "Genomic_coordinates" sheet) 1 78 67 11 70 14 3932 18521 0.0174912543728135 0.0136600175997183 0.0220480946527416 0.999244672241704 0.998733012789936 0.999586995715357 0.833333333333333 0.736200353091409 0.905776260344176 0.858974358974358 0.761661009337314 0.927442462144396 0.82716049382716 0.727041256277668 0.902158161484 28.6901646166651 15.031329346018 60.2420986896969 3.03557488297046e-39 7 1798 True False 23.5516276703967 13.126962046938 45.338511282674 0.0167541885471367 0.0130072440465206 0.0212289856351483 0.999244672241704 0.998733012789936 0.999586995715357 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 28 27 1 29 1 1713 6639 0.0166475315729047 0.0111767296935418 0.0238216970280875 0.999849397590361 0.999161185884076 0.99999618708438 0.966666666666666 0.827830544366587 0.999156429073369 0.964285714285714 0.816522402455376 0.999096201244342 0.964285714285714 0.816522402455376 0.999096201244342 104.642732049036 17.2131456410851 4180.61239160024 7.06093013562739e-18 7 886 True False 0 0 0 0 0 0 0 112.39404553415 18.5980697532113 4470.08268616241 0.0155172413793103 0.0102502119887774 0.0224969747050007 0.999849397590361 0.999161185884076 0.99999618708438 69 Assoc w R Marker of R 1) Assoc w R High-level resistance No change yes G 1 +Moxifloxacin gyrA p.Asp94Phe gyrA_p.Asp94Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.118754661339467 Inf 0.177574655011758 72.5 1798 False False Inf 0.118754661339467 Inf 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Asp94Tyr gyrA_p.Asp94Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 188 154 34 171 36 3831 18499 0.0427286356821589 0.036673781303974 0.0494619532930926 0.998057728621526 0.997312081775922 0.998639297645705 0.826086956521739 0.767452852049994 0.875121140300237 0.819148936170212 0.756556842057482 0.871384364109698 0.810526315789473 0.747468470187802 0.863625449812859 21.8714665192623 14.9703020942455 32.7608807721864 6.56641917864554e-83 4 1798 True False 22.9366353432524 15.9033821931933 33.9201328164671 0.0386449184441656 0.0328755258008 0.0451026424751319 0.998057728621526 0.997312081775922 0.998639297645705 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 70 65 5 68 5 1674 6635 0.0390355912743972 0.0304377821934853 0.0492267471934049 0.999246987951807 0.99824360331506 0.999755455269461 0.931506849315068 0.84735298622257 0.977387804497004 0.928571428571428 0.841127580536751 0.976401539539704 0.928571428571428 0.841127580536751 0.976401539539704 51.5262843488649 20.9126955808374 163.40089212701 6.26563914344105e-39 4 886 True False 0 0 0 0 0 0 0 53.9044205495818 21.9416076391918 171.798594547986 0.0373778033352501 0.0289635837479698 0.0473952099486747 0.999246987951807 0.99824360331506 0.999755455269461 136 Assoc w R Assoc w R Marker of R 1) Assoc w R High-level resistance No change yes G 1 +Moxifloxacin gyrA p.Asp94Val gyrA_p.Asp94Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 2 4000 18533 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 0.999892096034529 0.999610268708724 0.999986932062044 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 180.20051244703 1 732.5 1798 False False 4.63325 0.335715582549978 63.989229087488 0 0 0.000921794749483055 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 2 1740 6638 0.00114810562571756 0.000139071172424607 0.00414113746933503 0.999698795180722 0.998912372612698 0.9999635206173 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 148.462305278969 1 345 886 False False 0 0 0 0 0 0 0 3.81494252873563 0.27628448752053 52.6296495890773 0 0 0.00211779995375925 0.999698795180722 0.998912372612698 0.9999635206173 3 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Gln113Glu gyrA_p.Gln113Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 3 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Gln22His gyrA_p.Gln22His 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Gln25Glu gyrA_p.Gln25Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1300 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 630 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 3 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Gln277Arg gyrA_p.Gln277Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 24.660125576486 1 198.5 1798 False False 0 0 7.01683899052165 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 12 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Gln290Arg gyrA_p.Gln290Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Gln290His gyrA_p.Gln290His 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Gln305Arg gyrA_p.Gln305Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Gln336Lys gyrA_p.Gln336Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Gln475Pro gyrA_p.Gln475Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Gln573Arg gyrA_p.Gln573Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Gln594Arg gyrA_p.Gln594Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1274 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Gln603His gyrA_p.Gln603His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Gln613Glu gyrA_p.Gln613Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 9 220 3993 18315 0.00224887556221889 0.00102882864885218 0.00426475484372027 0.988130563798219 0.986465535457264 0.989639692345536 0.0393013100436681 0.018125959656867 0.0732926714714369 NA NA NA 0 0 0.0166278395399936 NA NA NA NA 1286 1798 False True 0.187640871525169 0.0846052273481097 0.363211419855157 0 0 0.000923409971909585 0.988130563798219 0.986465535457264 0.989639692345536 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 2 87 1740 6553 0.00114810562571756 0.000139071172424607 0.00414113746933503 0.986897590361445 0.98386300198363 0.989492558482583 0.0224719101123595 0.0027331333840906 0.078828124318326 NA NA NA 0 0 0.0415145659926378 NA NA NA NA 621 886 False True 1 1 1 0 0 0 0 0.0865768265292641 0.0103096507021742 0.322930236231724 0 0 0.00211779995375925 0.986897590361445 0.98386300198363 0.989492558482583 202 5) Not assoc w R UP from Uncertain to NotAwR yes 4 +Moxifloxacin gyrA p.Gln679His gyrA_p.Gln679His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Gln679Lys gyrA_p.Gln679Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Gln743His gyrA_p.Gln743His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Gln790Glu gyrA_p.Gln790Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Gln797Pro gyrA_p.Gln797Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Glu140Gly gyrA_p.Glu140Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Glu148Asp gyrA_p.Glu148Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Glu214Asp gyrA_p.Glu214Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 2 7 4000 18528 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 0.999622336120852 0.999222023868969 0.999848146482689 0.222222222222222 0.0281449734778982 0.600093573716312 0 0 0.409616397225003 0 0 0.409616397225003 0 0 3.21503428178409 0.615263059500422 175 1798 False False 1.32342857142857 0.134121374884385 6.95403216044878 0 0 0.000921794749483055 0.999622336120852 0.999222023868969 0.999848146482689 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 2 2 1740 6638 0.00114810562571756 0.000139071172424607 0.00414113746933503 0.999698795180722 0.998912372612698 0.9999635206173 0.5 0.067585986488543 0.932414013511457 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.328372694356 1 345 886 False False 0 0 0 0 0 0 0 3.81494252873563 0.27628448752053 52.6296495890773 0 0 0.00211779995375925 0.999698795180722 0.998912372612698 0.9999635206173 14 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Glu21Gln gyrA_p.Glu21Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1170 22 1148 3983 18412 19 123 0.995252373813093 0.992595880117021 0.997139271734347 0.00663609387644995 0.00551819098545909 0.00791271964740281 0.177852199151596 0.172863772696487 0.18292437979974 0.0188034188034188 0.0118205801605933 0.0283308565162995 0.00119344689161332 0.000748073199317664 0.00180633867827364 0.124060150375939 0.0623038623799126 0.250438266105696 4.37736456594952e-09 NA NA False True 1.40042821043484 0.858464645737369 2.40802408822717 0.536585365853658 0.374248428313749 0.693440567148598 0.00663609387644995 0.00551819098545909 0.00791271964740281 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 501 9 492 1737 6570 5 70 0.997129735935706 0.993314573421875 0.999067396598313 0.0105421686746987 0.00822709934432378 0.0133008703772098 0.209100758396533 0.200398681119699 0.218007353917976 0.0179640718562874 0.00824639688079155 0.033826592967144 0.00136798905608755 0.000625716484021367 0.00259527388163379 0.256097560975609 0.0747721532194829 1.00509756702184 0.0254379854421708 NA NA False True 0 1 1 0 0 1 0 3.70136986301369 1.50932625752946 11.7669688648326 0.642857142857142 0.351380110615991 0.87240157014084 0.0105421686746987 0.00822709934432378 0.0133008703772098 29601 Not assoc w R 5) Not assoc w R No change yes 1 +Moxifloxacin gyrA p.Glu21His gyrA_p.Glu21His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 180.110710654533 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Glu289Asp gyrA_p.Glu289Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 14 11 3988 18524 0.00349825087456271 0.00191380546833921 0.00586251148053981 0.99940652818991 0.998938363693644 0.999703704968061 0.56 0.349281633991335 0.755976334852791 0 0 0.521823750104981 0 0 0.284914152918154 0 0 5.07081969855086 0.593900283453695 157 1798 False False 5.91173520561685 2.4908551375558 14.3999836733402 0 0 0.000924567172214373 0.99940652818991 0.998938363693644 0.999703704968061 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 8 7 1734 6633 0.00459242250287026 0.00198470392380438 0.00902874874953196 0.99894578313253 0.997829124235982 0.999576048424705 0.533333333333333 0.265861347277396 0.787333270480692 0 0 0.521823750104981 0 0 0.409616397225003 0 0 4.17823897355498 0.590599650787801 85 886 False False 0 0 0 0 0 0 0 4.37172516065249 1.3828708794126 14.1805666101106 0 0 0.00212512018929921 0.99894578313253 0.997829124235982 0.999576048424705 3 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Glu289Gln gyrA_p.Glu289Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Glu303Lys gyrA_p.Glu303Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.118754661339467 Inf 0.177574655011758 72.5 1798 False False Inf 0.118754661339467 Inf 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Glu317Gly gyrA_p.Glu317Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Glu386Val gyrA_p.Glu386Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Glu412Ala gyrA_p.Glu412Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Glu412Gly gyrA_p.Glu412Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Glu429Ala gyrA_p.Glu429Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Glu459Ala gyrA_p.Glu459Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1260 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Glu459Lys gyrA_p.Glu459Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Glu466Ala gyrA_p.Glu466Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Glu508Ala gyrA_p.Glu508Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1329 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 641 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Glu514Gln gyrA_p.Glu514Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Glu719Gln gyrA_p.Glu719Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1278 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 615 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Glu738Asp gyrA_p.Glu738Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1303 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Glu739Gln gyrA_p.Glu739Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 1 2 4001 18533 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999892096034529 0.999610268708724 0.999986932062044 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 2.31604598850287 0.0392471382871788 44.494064095996 0.443741098632247 119.5 1798 False False 2.31604598850287 0.0392471382871788 44.494064095996 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 5 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Glu79Asp gyrA_p.Glu79Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 2 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Glu79Lys gyrA_p.Glu79Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Glu808Ala gyrA_p.Glu808Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1291 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Glu808Gln gyrA_p.Glu808Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Glu820_Ter839del gyrA_p.Glu820_Ter839del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Gly112Cys gyrA_p.Gly112Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Gly158Ser gyrA_p.Gly158Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Gly236Val gyrA_p.Gly236Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 2 2 4000 18533 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 0.999892096034529 0.999610268708724 0.999986932062044 0.5 0.067585986488543 0.932414013511457 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6751115303491 1 732.5 1798 False False 4.63325 0.335715582549978 63.989229087488 0 0 0.000921794749483055 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Gly247Ser gyrA_p.Gly247Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 247 1482 3755 17053 0.0617191404297851 0.054460719664997 0.069625232151701 0.920043161586188 0.916045267373017 0.92390868536397 0.142857142857142 0.126690570774283 0.160245933105408 NA NA NA 0 0 0.00248602714213932 NA NA NA NA NA NA False True 0.756901908566356 0.655790835070163 0.870817953808896 0 0 0.000981908944265929 0.920043161586188 0.916045267373017 0.92390868536397 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 59 404 1683 6236 0.0338691159586682 0.0258806934444996 0.0434731258412393 0.939156626506024 0.933136199004661 0.944787686146156 0.12742980561555 0.0984385332725184 0.161278764475335 NA NA NA 0 0 0.00908932975360521 NA NA NA NA NA NA False True 0 1 1 0 0 1 0 0.541118817764129 0.402450411648379 0.716749735881626 0 0 0.00218944722249098 0.939156626506024 0.933136199004661 0.944787686146156 1509 Not assoc w R 5) Not assoc w R No change yes 1 +Moxifloxacin gyrA p.Gly265Ser gyrA_p.Gly265Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Gly294Ala gyrA_p.Gly294Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Gly311Ala gyrA_p.Gly311Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Gly351Ala gyrA_p.Gly351Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 21 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Gly477Glu gyrA_p.Gly477Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 11.2104345733627 1 732.5 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Gly503Arg gyrA_p.Gly503Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 11.2104345733627 1 732.5 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Gly503Val gyrA_p.Gly503Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1270 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Gly548Arg gyrA_p.Gly548Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Gly63Ala gyrA_p.Gly63Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 2 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Gly63Arg gyrA_p.Gly63Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Gly646Ser gyrA_p.Gly646Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Gly668Asp gyrA_p.Gly668Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 20 5 15 3816 16937 186 1598 0.953523238380809 0.94653715654056 0.959837083434168 0.0862152684111141 0.0822126464526717 0.0903482489482984 0.183877029827012 0.1786270214847 0.189215741516452 0.25 0.0865714691014345 0.491045871707957 0.000295124542556959 9.58328574022386e-05 0.000688586702503539 2.86379928315412 0.804283523892234 8.40299124662842 0.0521954184613676 NA NA False True 1.93568956683877 1.65487175649951 2.27439438228751 0.0261780104712041 0.0085533904580788 0.0600303979971419 0.0862152684111141 0.0822126464526717 0.0903482489482984 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 9 0 9 1654 5921 88 719 0.949483352468427 0.938129947490012 0.959290041799271 0.10828313253012 0.100906960444487 0.116005260599845 0.218349834983498 0.209090221903962 0.227826655170401 0 0 0.336267116879942 0 0 0.000622822255821634 0 0 4.2172795768105 0.608230680602003 NA NA False True 0 1 1 0 0 1 0 2.28237321705485 1.81366684614664 2.90044842914096 0 0 0.041052629058078 0.10828313253012 0.100906960444487 0.116005260599845 26150 Not assoc w R 5) Not assoc w R No change yes 1 +Moxifloxacin gyrA p.Gly694Ala gyrA_p.Gly694Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Gly702Ser gyrA_p.Gly702Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Gly729Arg gyrA_p.Gly729Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 11 4002 18524 0 0 0.000921334294721226 0.99940652818991 0.998938363693644 0.999703704968061 0 0 0.284914152918154 0 0 0.975 0 0 0.284914152918154 0 0 180.023495981585 1 198.5 1798 False False 0 0 1.84512569595635 0 0 0.000921334294721226 0.99940652818991 0.998938363693644 0.999703704968061 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 1742 6634 0 0 0.00211537106925253 0.999096385542168 0.998034257105878 0.999668319522948 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 609 886 False False 0 0 0 0 0 0 0 0 0 3.23733664541029 0 0 0.00211537106925253 0.999096385542168 0.998034257105878 0.999668319522948 5 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Gly744Ala gyrA_p.Gly744Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Gly780Cys gyrA_p.Gly780Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1330 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 642 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Gly795Arg gyrA_p.Gly795Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Gly823Cys gyrA_p.Gly823Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Gly823Ser gyrA_p.Gly823Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Gly832Arg gyrA_p.Gly832Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Gly88Ala gyrA_p.Gly88Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 17 7 10 11 13 3991 18522 0.00274862568715642 0.00137287782368726 0.00491271640366202 0.99929862422444 0.998800924705247 0.999626495767062 0.458333333333333 0.255530201994746 0.671791924304822 0.411764705882352 0.184436961783946 0.670752846053242 0.35 0.153909204784541 0.592188534532828 3.24865948383863 1.04875324741663 9.45788310531852 0.0204210473887045 33 1798 False False 3.92695102442033 1.59154265356206 9.50384849422763 0.00175087543771885 0.000704223389637803 0.00360412450280189 0.99929862422444 0.998800924705247 0.999626495767062 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 3 2 5 3 1737 6637 0.00287026406429391 0.000932603401686605 0.00668542657812442 0.999548192771084 0.998680200855815 0.999906816794257 0.625 0.244863216366551 0.914766585862746 0.6 0.146632799634673 0.947255049473683 0.5 0.118117248757025 0.881882751242974 5.7314335060449 0.65583511408046 68.7558717660041 0.0639169589547557 23 886 False False 0 0 0 0 0 0 0 6.368259451161 1.23725577985432 41.0620446487939 0.00172413793103448 0.000355699921957955 0.0050303183364639 0.999548192771084 0.998680200855815 0.999906816794257 18 Assoc w RI FQ cross-resistance 2) Assoc w R - Interim Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance) No change yes FQ X-R F 1 +Moxifloxacin gyrA p.Gly88Asp gyrA_p.Gly88Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.118754661339467 Inf 0.177574655011758 72.5 1798 False False Inf 0.118754661339467 Inf 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0977360898734989 Inf 0.207826294440467 35.5 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Gly88Cys gyrA_p.Gly88Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 35 30 5 33 5 3969 18530 0.00824587706146926 0.00568268565982541 0.0115609540945056 0.999730240086323 0.999370583585258 0.99991240407437 0.868421052631579 0.719136154116246 0.955862559942085 0.857142857142857 0.697428648309048 0.951939221596361 0.857142857142857 0.697428648309048 0.951939221596361 28.0120937263794 10.7521602471889 92.5403789454307 3.46403578154236e-18 10 1798 True False 30.8133030990173 11.9411427461292 101.183650298686 0.00750187546886721 0.0050670419535023 0.0106922061691174 0.999730240086323 0.999370583585258 0.99991240407437 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 9 9 0 10 0 1732 6640 0.00574052812858783 0.00275613621871035 0.0105316187829875 1 0.999444600156968 1 1 0.691502892181239 1 1 0.663732883120057 1 1 0.663732883120057 1 Inf 7.55542867203689 Inf 7.08594202041411e-07 10 886 True False 0 0 0 0 0 0 0 Inf 8.58115529782205 Inf 0.00516944284893739 0.00236644110000124 0.00979043584981775 1 0.999444600156968 1 31 Assoc w R 1) Assoc w R High-level resistance No change yes G 1 +Moxifloxacin gyrA p.His192Gln gyrA_p.His192Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1301 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.His334Tyr gyrA_p.His334Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.His368Gln gyrA_p.His368Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 7.01683899052165 1 732.5 1798 False False 0 0 7.01683899052165 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 10 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.His389Pro gyrA_p.His389Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 4001 18533 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999892096034529 0.999610268708724 0.999986932062044 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6689469404428 1 732.5 1798 False False 2.31604598850287 0.0392471382871788 44.494064095996 0 0 0.000921564464586207 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.His490Arg gyrA_p.His490Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.118754661339467 Inf 0.177574655011758 72.5 1798 False False Inf 0.118754661339467 Inf 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.His490Asn gyrA_p.His490Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.His490Tyr gyrA_p.His490Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1302 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.His557Arg gyrA_p.His557Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1322 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.His70Arg gyrA_p.His70Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 9 3 3993 18532 0.00224887556221889 0.00102882864885218 0.00426475484372027 0.999838144051794 0.999527061819887 0.99996662016845 0.75 0.42814153812181 0.945139355472007 0.333333333333333 0.00840375865961264 0.905700675949754 0.25 0.00630946320970987 0.805879550316756 2.320560981718 0.0393236288925902 44.5807133130627 0.443164263368525 118 1798 False False 13.923365890308 3.47212981098601 79.9610730634449 0.000250375563345017 6.33894034556031e-06 0.0013942052348289 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 4 1 1738 6639 0.00229621125143513 0.000625983621299944 0.00586868734668228 0.999849397590361 0.999161185884076 0.99999618708438 0.8 0.28358206388191 0.994949236620532 0 0 0.975 0 0 0.975 0 0 148.655087036126 1 345 886 False False 0 0 0 0 0 0 0 15.2796317606444 1.51015569957238 749.366827684443 0 0 0.00212023442240146 0.999849397590361 0.999161185884076 0.99999618708438 5 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Ile153Met gyrA_p.Ile153Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Ile15Val gyrA_p.Ile15Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 6 4002 18529 0 0 0.000921334294721226 0.999676288103587 0.999295549654279 0.999881194471086 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 5.0544394993781 0.593751589252307 129 1798 False False 0 0 3.93385874811763 0 0 0.000921334294721226 0.999676288103587 0.999295549654279 0.999881194471086 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.302036906212 1 345 886 False False 0 0 0 0 0 0 0 0 0 9.22785363871091 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 5 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Ile189Met gyrA_p.Ile189Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Ile189Val gyrA_p.Ile189Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1266 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Ile284Val gyrA_p.Ile284Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Ile314Val gyrA_p.Ile314Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1296 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 626 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Ile328Leu gyrA_p.Ile328Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1315 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 636 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Ile348Val gyrA_p.Ile348Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Ile390Thr gyrA_p.Ile390Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1312 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Ile427Val gyrA_p.Ile427Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Ile452Thr gyrA_p.Ile452Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Ile462Val gyrA_p.Ile462Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 3 5 3999 18530 0.000749625187406296 0.000154617422592445 0.00218914487959466 0.999730240086323 0.999370583585258 0.99991240407437 0.375 0.0852334141372535 0.755136783633448 0 0 0.521823750104981 0 0 0.521823750104981 0 0 5.05850531279454 0.593788264323505 152 1798 False False 2.78019504876219 0.431541359444734 14.2924507397754 0 0 0.000922025149498025 0.999730240086323 0.999370583585258 0.99991240407437 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 2 3 1740 6637 0.00114810562571756 0.000139071172424607 0.00414113746933503 0.999548192771084 0.998680200855815 0.999906816794257 0.4 0.0527449505263169 0.853367200365326 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.23846214020534 1 345 886 False False 0 0 0 0 0 0 0 2.54291187739463 0.212204746732873 22.2132783392172 0 0 0.00211779995375925 0.999548192771084 0.998680200855815 0.999906816794257 6 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Ile520Leu gyrA_p.Ile520Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1297 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Ile554Val gyrA_p.Ile554Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Ile707Val gyrA_p.Ile707Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Ile815Met gyrA_p.Ile815Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1287 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 622 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Ile92Val gyrA_p.Ile92Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1271 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 613 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Leu105Arg gyrA_p.Leu105Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 3 4001 18532 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999838144051794 0.999527061819887 0.99996662016845 0.25 0.00630946320970987 0.805879550316756 1 0.025 1 0.25 0.00630946320970987 0.805879550316756 Inf 0.118735440167692 Inf 0.177598295908405 87 1798 False False 1.5439473464967 0.0294026895471131 19.2327580431529 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Leu12Phe gyrA_p.Leu12Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 180.110710654533 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Leu134Met gyrA_p.Leu134Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1298 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 627 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 2 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Leu142Val gyrA_p.Leu142Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 7.01683899052165 1 732.5 1798 False False 0 0 7.01683899052165 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Leu205Val gyrA_p.Leu205Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Leu296Pro gyrA_p.Leu296Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 14 0 14 0 14 4002 18521 0 0 0.000921334294721226 0.999244672241704 0.998733012789936 0.999586995715357 0 0 0.231635761650116 0 0 0.231635761650116 0 0 0.231635761650116 0 0 1.39588267491558 0.151128437513449 57 1798 False False 0 0 1.39588267491558 0 0 0.000921334294721226 0.999244672241704 0.998733012789936 0.999586995715357 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 1742 6635 0 0 0.00211537106925253 0.999246987951807 0.99824360331506 0.999755455269461 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.16029237021718 0.590665917903267 90.5 886 False False 0 0 0 0 0 0 0 0 0 4.16029237021718 0 0 0.00211537106925253 0.999246987951807 0.99824360331506 0.999755455269461 49 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Leu346Val gyrA_p.Leu346Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 1 8 4001 18527 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999568384138117 0.999149722782159 0.999813641077243 0.111111111111111 0.00280913674659921 0.482496514917337 0 0 0.602364635616474 0 0 0.369416647552819 0 0 7.01707832399665 1 732.5 1798 False False 0.578824043989002 0.0130447733848513 4.31945136015563 0 0 0.000921564464586207 0.999568384138117 0.999149722782159 0.999813641077243 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 4 1742 6636 0 0 0.00211537106925253 0.999397590361445 0.998458316867766 0.999835840034063 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 148.247680227162 1 345 886 False False 0 0 0 0 0 0 0 0 0 5.77543554850383 0 0 0.00211537106925253 0.999397590361445 0.998458316867766 0.999835840034063 14 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Leu398Phe gyrA_p.Leu398Phe 1 missense_variant (see "Genomic_coordinates" sheet) 2 6 0 6 1 7 4001 18528 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999622336120852 0.999222023868969 0.999848146482689 0.125 0.0031597235312519 0.526509670875206 0 0 0.4592581264399 0 0 0.409616397225003 0 0 3.93462995458355 0.599064065645006 160 1798 False False 0.661548898489663 0.0146783588023133 5.15155114398686 0 0 0.000921564464586207 0.999622336120852 0.999222023868969 0.999848146482689 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 625 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 36 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Leu401Val gyrA_p.Leu401Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Leu425Phe gyrA_p.Leu425Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Leu455Arg gyrA_p.Leu455Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1307 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Leu455Val gyrA_p.Leu455Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 24.660125576486 1 198.5 1798 False False 0 0 7.01683899052165 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Leu465Gln gyrA_p.Leu465Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Leu549Val gyrA_p.Leu549Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1331 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Leu566Trp gyrA_p.Leu566Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1279 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 616 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Leu653Val gyrA_p.Leu653Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 180.16529327284 1 732.5 1798 False False 4.63234191452137 0.0589984289392935 362.546724531758 0 0 0.000921564464586207 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Leu659Val gyrA_p.Leu659Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 4002 18530 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 5.05471226039473 0.593754047365944 137.5 1798 False False 0 0 5.05471226039473 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 1742 6635 0 0 0.00211537106925253 0.999246987951807 0.99824360331506 0.999755455269461 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.16029237021718 0.590665917903267 90.5 886 False False 0 0 0 0 0 0 0 0 0 4.16029237021718 0 0 0.00211537106925253 0.999246987951807 0.99824360331506 0.999755455269461 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Leu671Val gyrA_p.Leu671Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Leu711Met gyrA_p.Leu711Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 1 8 4001 18527 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999568384138117 0.999149722782159 0.999813641077243 0.111111111111111 0.00280913674659921 0.482496514917337 0 0 0.409616397225003 0 0 0.369416647552819 0 0 3.21405542408544 0.615291450325908 176 1798 False False 0.578824043989002 0.0130447733848513 4.31945136015563 0 0 0.000921564464586207 0.999568384138117 0.999149722782159 0.999813641077243 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 7 1742 6633 0 0 0.00211537106925253 0.99894578313253 0.997829124235982 0.999576048424705 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 3.2368482985604 0.355654483411955 58 886 False False 0 0 0 0 0 0 0 0 0 2.64457250939033 0 0 0.00211537106925253 0.99894578313253 0.997829124235982 0.999576048424705 25 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Leu724Val gyrA_p.Leu724Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Leu766Ser gyrA_p.Leu766Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1316 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 637 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Leu812Val gyrA_p.Leu812Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.118754661339467 Inf 0.177574655011758 72.5 1798 False False Inf 0.118754661339467 Inf 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0977360898734989 Inf 0.207826294440467 35.5 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Lys224Glu gyrA_p.Lys224Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Lys319Asn gyrA_p.Lys319Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Lys319Glu gyrA_p.Lys319Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 4000 18534 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 0.999946048017264 0.999699435860871 0.999998634054993 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 180.210207769499 1 732.5 1798 False False 9.267 0.482236652039982 544.73752523911 0 0 0.000921794749483055 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Lys319Thr gyrA_p.Lys319Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.118754661339467 Inf 0.177574655011758 72.5 1798 False False Inf 0.118754661339467 Inf 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Lys333Asn gyrA_p.Lys333Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Lys633Arg gyrA_p.Lys633Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Lys636Asn gyrA_p.Lys636Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Lys636Glu gyrA_p.Lys636Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 180.110710654533 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Lys636Thr gyrA_p.Lys636Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 50 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Lys799Arg gyrA_p.Lys799Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1280 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 617 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Met141Ile gyrA_p.Met141Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Met141Thr gyrA_p.Met141Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 3 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Met141Val gyrA_p.Met141Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Met220Arg gyrA_p.Met220Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1308 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 634 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 2 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Met438Ile gyrA_p.Met438Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Met703Val gyrA_p.Met703Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1267 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Met804Val gyrA_p.Met804Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Met99Ile gyrA_p.Met99Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Phe152Leu gyrA_p.Phe152Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 11.2104345733627 1 732.5 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.22785363871091 1 345 886 False False 0 0 0 0 0 0 0 0 0 9.22785363871091 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Phe228Leu gyrA_p.Phe228Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Phe569Cys gyrA_p.Phe569Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Phe640Val gyrA_p.Phe640Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Phe683Leu gyrA_p.Phe683Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Phe683Val gyrA_p.Phe683Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Phe705Leu gyrA_p.Phe705Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 7 4002 18528 0 0 0.000921334294721226 0.999622336120852 0.999222023868969 0.999848146482689 0 0 0.409616397225003 0 0 0.602364635616474 0 0 0.409616397225003 0 0 7.0157031190513 1 732.5 1798 False False 0 0 3.21342445526953 0 0 0.000921334294721226 0.999622336120852 0.999222023868969 0.999848146482689 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 148.269965029351 1 345 886 False False 0 0 0 0 0 0 0 0 0 9.22785363871091 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 3 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Pro102Leu gyrA_p.Pro102Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1313 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Pro108Ser gyrA_p.Pro108Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 7.01683899052165 1 732.5 1798 False False 0 0 7.01683899052165 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Pro119Leu gyrA_p.Pro119Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Pro123Gln gyrA_p.Pro123Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 11.2104345733627 1 732.5 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.22785363871091 1 345 886 False False 0 0 0 0 0 0 0 0 0 9.22785363871091 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Pro154Arg gyrA_p.Pro154Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 10 0 10 0 10 4002 18525 0 0 0.000921334294721226 0.999460480172646 0.999008028394192 0.999741249920483 0 0 0.30849710781876 0 0 0.30849710781876 0 0 0.30849710781876 0 0 2.06609723386524 0.22623165660618 91 1798 False False 0 0 2.06609723386524 0 0 0.000921334294721226 0.999460480172646 0.999008028394192 0.999741249920483 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 11 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Pro154Leu gyrA_p.Pro154Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Pro17Leu gyrA_p.Pro17Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Pro17Ser gyrA_p.Pro17Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Pro275Ala gyrA_p.Pro275Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 180.110710654533 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Pro472Ser gyrA_p.Pro472Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 30 1 29 4 30 3998 18505 0.000999500249875062 0.000272395196018755 0.00255712257980299 0.998381440517939 0.997690205325877 0.998907706532097 0.117647058823529 0.0330016803364695 0.274503487142355 0.0333333333333333 0.000843570926630479 0.172169455633412 0.032258064516129 0.000816370071846613 0.167021116230227 0.159605664901416 0.00391052647166715 0.96325683878219 0.0320222839751073 37 1798 False False 0.617141904285476 0.157875330896474 1.75274087052879 0.000250062515628907 6.33101471380292e-06 0.00139246303880997 0.998381440517939 0.997690205325877 0.998907706532097 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 1742 6634 0 0 0.00211537106925253 0.999096385542168 0.998034257105878 0.999668319522948 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.23733664541029 0.355668965817841 60.5 886 False False 0 0 0 0 0 0 0 0 0 3.23733664541029 0 0 0.00211537106925253 0.999096385542168 0.998034257105878 0.999668319522948 37 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Pro50Arg gyrA_p.Pro50Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1320 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Pro621Leu gyrA_p.Pro621Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 4 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Pro66Ala gyrA_p.Pro66Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Pro741Ala gyrA_p.Pro741Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Pro7Leu gyrA_p.Pro7Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Pro7Ser gyrA_p.Pro7Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Pro8Ala gyrA_p.Pro8Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 26 0 26 1 29 4001 18506 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.998435392500674 0.997753729474072 0.998951915188256 0.0333333333333333 0.000843570926630479 0.172169455633412 0 0 0.132274604497754 0 0 0.119444869069502 0 0 0.705466518203692 0.00923626281212658 29 1798 False False 0.159494609106344 0.00390780923955051 0.962585803986783 0 0 0.000921564464586207 0.998435392500674 0.997753729474072 0.998951915188256 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 12 0 12 0 12 1742 6628 0 0 0.00211537106925253 0.998192771084337 0.996845265024717 0.999065840721332 0 0 0.264648469397051 0 0 0.264648469397051 0 0 0.264648469397051 0 0 1.37098656231317 0.144212204250456 28.5 886 False False 0 0 0 0 0 0 0 0 0 1.37098656231317 0 0 0.00211537106925253 0.998192771084337 0.996845265024717 0.999065840721332 31 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Pro8Leu gyrA_p.Pro8Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Ser104Leu gyrA_p.Ser104Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Ser168Thr gyrA_p.Ser168Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1324 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 640 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Ser237Ala gyrA_p.Ser237Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 180.110710654533 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 148.292249815985 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 10 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Ser237Pro gyrA_p.Ser237Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Ser250Ala gyrA_p.Ser250Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 25 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Ser250Tyr gyrA_p.Ser250Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Ser411Ala gyrA_p.Ser411Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Ser506Asn gyrA_p.Ser506Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Ser536Arg gyrA_p.Ser536Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 7.01683899052165 1 732.5 1798 False False 0 0 7.01683899052165 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 3 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Ser62Phe gyrA_p.Ser62Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Ser642Cys gyrA_p.Ser642Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Ser645Leu gyrA_p.Ser645Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Ser680Ala gyrA_p.Ser680Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Ser698Leu gyrA_p.Ser698Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 1 4 1 4 4001 18531 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999784192069058 0.999447539013843 0.999941196572055 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 1.15789802549362 0.0235059760051305 11.7081385811536 1 732.5 1798 False False 1.15789802549362 0.0235059760051305 11.7081385811536 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999784192069058 0.999447539013843 0.999941196572055 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Ser69Gly gyrA_p.Ser69Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Ser728Ala gyrA_p.Ser728Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Ser91Pro gyrA_p.Ser91Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 208 150 58 175 68 3827 18467 0.0437281359320339 0.0376029947025197 0.0505300704639953 0.996331265173995 0.995351289933912 0.997149991596574 0.720164609053498 0.659202465011439 0.775666828164883 0.721153846153846 0.65493742182868 0.780946405185554 0.688073394495412 0.622021765169908 0.748924364767356 12.4796139949361 9.13586616357852 17.2362060455556 4.3002354121866e-67 5 1798 True False 12.4184394165296 9.30816576666307 16.7222960056018 0.0377168720140809 0.0320121030811002 0.0441129763395053 0.996331265173995 0.995351289933912 0.997149991596574 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 85 67 18 78 21 1664 6619 0.044776119402985 0.0355518531977249 0.055570032444891 0.99683734939759 0.995169594460748 0.998041236179345 0.787878787878787 0.694212956709099 0.863638063617293 0.788235294117647 0.68612692508316 0.869397863063347 0.761363636363636 0.658642867083894 0.845806732489508 14.8061231303418 8.66323128750204 26.5429913111791 1.15808012856382e-30 5 886 True False 0 0 0 0 0 0 0 14.7745535714285 8.99370303910679 25.278942198145 0.0387059503177354 0.0301201205718481 0.0488968394572365 0.99683734939759 0.995169594460748 0.998041236179345 217 Assoc w R Assoc w R Marker of R 1) Assoc w R Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance) No change yes F 1 +Moxifloxacin gyrA p.Ser95Ala gyrA_p.Ser95Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 4 3 3998 18532 0.000999500249875062 0.000272395196018755 0.00255712257980299 0.999838144051794 0.999527061819887 0.99996662016845 0.571428571428571 0.184051567640083 0.901011721557492 0 0 0.841886116991581 0 0 0.707598226178713 0 0 24.6861187209904 1 732.5 1798 False False 6.18042354510588 1.04502289791603 42.2067389811122 0 0 0.000922255664717455 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 1741 6638 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999698795180722 0.998912372612698 0.9999635206173 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3167233028695 1 345 886 False False 0 0 0 0 0 0 0 1.90637564618035 0.032294587677361 36.6438813236649 0 0 0.00211658481469046 0.999698795180722 0.998912372612698 0.9999635206173 6 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Ser95Thr gyrA_p.Ser95Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 17 0 17 3665 17014 337 1521 0.915792103948026 0.906756706094357 0.924214814040467 0.0820609657404909 0.0781485959523372 0.0861050289003663 0.177232941631606 0.17204972458714 0.182507059281919 0 0 0.195064322969093 0 0 0.000216790853532506 0 0 1.10066883287752 0.055252525970487 NA NA False True 0.972225177450303 0.858671105646916 1.10313696812559 0 0 0.0108865378595953 0.0820609657404909 0.0781485959523372 0.0861050289003663 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 12 0 12 1598 5987 144 653 0.917336394948335 0.903403420533653 0.929843442061788 0.0983433734939759 0.0912832281080177 0.105758454716697 0.210678971654581 0.20154842564263 0.220032371992427 0 0 0.264648469397051 0 0 0.000615958449843217 0 0 1.65481130988162 0.139087359299238 NA NA False True 0 1 1 0 0 1 0 1.21037015385186 1.00014383327465 1.47225705308819 0 0 0.0252918814875166 0.0983433734939759 0.0912832281080177 0.105758454716697 26228 Not assoc w R Not assoc w R 5) Not assoc w R No change yes 1 +Moxifloxacin gyrA p.Ter839ext*? gyrA_p.Ter839ext*? 1 stop_lost (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1261 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 606 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 5 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Thr230Ser gyrA_p.Thr230Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Thr267Ile gyrA_p.Thr267Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 23 0 23 4 26 3998 18509 0.000999500249875062 0.000272395196018755 0.00255712257980299 0.99859724844888 0.997945314710086 0.999083477869708 0.133333333333333 0.0375534963383633 0.307218350276126 0 0 0.148185128915224 0 0 0.132274604497754 0 0 0.805820872906605 0.0240648835000495 36 1798 False False 0.712240735752491 0.180552908483182 2.05466470962898 0 0 0.000922255664717455 0.99859724844888 0.997945314710086 0.999083477869708 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Thr272Ile gyrA_p.Thr272Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 1 6 4001 18529 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999676288103587 0.999295549654279 0.999881194471086 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.521823750104981 0 0 0.4592581264399 0 0 5.05570314974372 0.593762969912843 145 1798 False False 0.771848704490544 0.0167759984530013 6.36465776860659 0 0 0.000921564464586207 0.999676288103587 0.999295549654279 0.999881194471086 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 5 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Thr339Ser gyrA_p.Thr339Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Thr355Ala gyrA_p.Thr355Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1326 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Thr355Met gyrA_p.Thr355Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Thr377Ile gyrA_p.Thr377Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 6 4002 18529 0 0 0.000921334294721226 0.999676288103587 0.999295549654279 0.999881194471086 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 5.0544394993781 0.593751589252307 129 1798 False False 0 0 3.93385874811763 0 0 0.000921334294721226 0.999676288103587 0.999295549654279 0.999881194471086 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.22785363871091 1 345 886 False False 0 0 0 0 0 0 0 0 0 9.22785363871091 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 5 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Thr378Ile gyrA_p.Thr378Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Thr413Ala gyrA_p.Thr413Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1294 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Thr563Ser gyrA_p.Thr563Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Thr572Asn gyrA_p.Thr572Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 6 4002 18529 0 0 0.000921334294721226 0.999676288103587 0.999295549654279 0.999881194471086 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1327 1798 False False 0 0 3.93385874811763 0 0 0.000921334294721226 0.999676288103587 0.999295549654279 0.999881194471086 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Thr590Ala gyrA_p.Thr590Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 180.16529327284 1 732.5 1798 False False 4.63234191452137 0.0589984289392935 362.546724531758 0 0 0.000921564464586207 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Thr590Met gyrA_p.Thr590Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Thr5Ala gyrA_p.Thr5Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 12 1 11 3 11 3999 18524 0.000749625187406296 0.000154617422592445 0.00218914487959466 0.99940652818991 0.998938363693644 0.999703704968061 0.214285714285714 0.0465792878898673 0.507975677048471 0.0833333333333333 0.00210759323186022 0.384796165150944 0.0833333333333333 0.00210759323186022 0.384796165150944 0.421105276319079 0.00978426546570381 2.89887095510803 0.705281039502878 185 1798 False False 1.26331582895723 0.226188608253928 4.78526100700425 0.00025 6.32943196513345e-06 0.00139211512196626 0.99940652818991 0.998938363693644 0.999703704968061 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 1 4 2 4 1740 6636 0.00114810562571756 0.000139071172424607 0.00414113746933503 0.999397590361445 0.998458316867766 0.999835840034063 0.333333333333333 0.0432718682927417 0.777221904496487 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 0.953448275862068 0.0193493091104549 9.64034726840089 1 345 886 False False 0 0 0 0 0 0 0 1.90689655172413 0.172334634649247 13.3169802580519 0.000574382538770821 1.45420010902056e-05 0.00319605610685329 0.999397590361445 0.998458316867766 0.999835840034063 12 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Thr638Asn gyrA_p.Thr638Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Thr638Ile gyrA_p.Thr638Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 11.2104345733627 1 732.5 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Thr686Ser gyrA_p.Thr686Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1275 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Thr697Ala gyrA_p.Thr697Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 3 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Thr735Ser gyrA_p.Thr735Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Thr80Ala gyrA_p.Thr80Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 24 3999 18511 0.000749625187406296 0.000154617422592445 0.00218914487959466 0.998705152414351 0.99807397809504 0.999170196040018 0.111111111111111 0.0235274543808539 0.291586924273551 NA NA NA 0 0 0.142473597722525 NA NA NA NA NA NA False True 0.578613403350837 0.111456644840301 1.90671359733105 0 0 0.000922025149498025 0.998705152414351 0.99807397809504 0.999170196040018 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 1 17 1741 6623 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.997439759036144 0.995903960705664 0.998507879902128 0.0555555555555555 0.00140555616736942 0.272943599673368 NA NA NA 0 0 0.195064322969093 NA NA NA NA NA NA False True 0 0 0 0 0 1 0 0.223772679663479 0.00535502511025759 1.43021074798802 0 0 0.00211658481469046 0.997439759036144 0.995903960705664 0.998507879902128 154 Not assoc w RI Literature evidence (PMID 28137812) 4) Not assoc w R - Interim No change yes Lit. (PMID 28137812) 1 +Moxifloxacin gyrA p.Thr836Ala gyrA_p.Thr836Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 180.16529327284 1 732.5 1798 False False 4.63234191452137 0.0589984289392935 362.546724531758 0 0 0.000921564464586207 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Thr836Arg gyrA_p.Thr836Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 4002 18530 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 5.05471226039473 0.593754047365944 137.5 1798 False False 0 0 5.05471226039473 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 1742 6635 0 0 0.00211537106925253 0.999246987951807 0.99824360331506 0.999755455269461 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.16029237021718 0.590665917903267 90.5 886 False False 0 0 0 0 0 0 0 0 0 4.16029237021718 0 0 0.00211537106925253 0.999246987951807 0.99824360331506 0.999755455269461 7 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Thr836Lys gyrA_p.Thr836Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Tyr276His gyrA_p.Tyr276His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Tyr365His gyrA_p.Tyr365His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Tyr379Cys gyrA_p.Tyr379Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 4 3 3998 18532 0.000999500249875062 0.000272395196018755 0.00255712257980299 0.999838144051794 0.999527061819887 0.99996662016845 0.571428571428571 0.184051567640083 0.901011721557492 0 0 0.841886116991581 0 0 0.707598226178713 0 0 24.6861187209904 1 732.5 1798 False False 6.18042354510588 1.04502289791603 42.2067389811122 0 0 0.000922255664717455 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 2 1740 6638 0.00114810562571756 0.000139071172424607 0.00414113746933503 0.999698795180722 0.998912372612698 0.9999635206173 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 148.462305278969 1 345 886 False False 0 0 0 0 0 0 0 3.81494252873563 0.27628448752053 52.6296495890773 0 0 0.00211779995375925 0.999698795180722 0.998912372612698 0.9999635206173 4 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Tyr722Cys gyrA_p.Tyr722Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 11.2104345733627 1 732.5 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Val150Ala gyrA_p.Val150Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Val223Ile gyrA_p.Val223Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Val235Ala gyrA_p.Val235Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Val257Leu gyrA_p.Val257Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Val278Ile gyrA_p.Val278Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 6 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Val310Ile gyrA_p.Val310Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1325 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Val310Phe gyrA_p.Val310Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Val326Gly gyrA_p.Val326Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 11.2104345733627 1 732.5 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Val327Leu gyrA_p.Val327Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Val352Leu gyrA_p.Val352Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1292 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Val352Met gyrA_p.Val352Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Val479Met gyrA_p.Val479Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 180.110710654533 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 148.292249815985 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Val516Ala gyrA_p.Val516Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1288 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Val517Leu gyrA_p.Val517Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1276 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Val51Ala gyrA_p.Val51Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1304 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Val544Leu gyrA_p.Val544Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Val596Met gyrA_p.Val596Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.118754661339467 Inf 0.177574655011758 72.5 1798 False False Inf 0.118754661339467 Inf 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Val624Leu gyrA_p.Val624Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 4 2 3998 18533 0.000999500249875062 0.000272395196018755 0.00255712257980299 0.999892096034529 0.999610268708724 0.999986932062044 0.666666666666666 0.222778095503512 0.956728131707258 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6874304446729 1 732.5 1798 False False 9.27113556778389 1.3280388413788 102.537019047163 0 0 0.000922255664717455 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 1741 6639 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999849397590361 0.999161185884076 0.99999618708438 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 148.399526333966 1 596 886 False False 0 0 0 0 0 0 0 3.81332567489948 0.0485516368820753 298.645085154332 0 0 0.00211658481469046 0.999849397590361 0.999161185884076 0.99999618708438 5 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Val649Met gyrA_p.Val649Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Val651Ala gyrA_p.Val651Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Val651Ile gyrA_p.Val651Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 11.2104345733627 1 732.5 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 7 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Val674Ile gyrA_p.Val674Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Val716Gly gyrA_p.Val716Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrA p.Val716Phe gyrA_p.Val716Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Val750Ala gyrA_p.Val750Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Val768Ala gyrA_p.Val768Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Val783Leu gyrA_p.Val783Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 7 4002 18528 0 0 0.000921334294721226 0.999622336120852 0.999222023868969 0.999848146482689 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1317 1798 False False 0 0 3.21342445526953 0 0 0.000921334294721226 0.999622336120852 0.999222023868969 0.999848146482689 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrA p.Val783Met gyrA_p.Val783Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 11.2104345733627 1 732.5 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Moxifloxacin gyrB c.-100C>T gyrB_c.-100C>T 1 upstream_gene_variant 5140 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1387 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 677 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 2 3) Uncertain significance No change no 1 +Moxifloxacin gyrB c.1011A>G gyrB_c.1011A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 11.2104345733627 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.22785363871091 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1020C>T gyrB_c.1020C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1026C>T gyrB_c.1026C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.-102G>A gyrB_c.-102G>A 1 upstream_gene_variant 5138 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrB c.1035C>G gyrB_c.1035C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.-104A>C gyrB_c.-104A>C 1 upstream_gene_variant 5136 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrB c.1059C>T gyrB_c.1059C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1068T>G gyrB_c.1068T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.-107A>C gyrB_c.-107A>C 1 upstream_gene_variant 5133 1 0 0 0 0 5 4002 18530 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1392 1798 False False 0 0 5.05471226039473 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrB c.1080G>A gyrB_c.1080G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 11.2104345733627 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1098G>A gyrB_c.1098G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.-10T>C gyrB_c.-10T>C 1 upstream_gene_variant 5230 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 2 3) Uncertain significance No change no 1 +Moxifloxacin gyrB c.1107C>T gyrB_c.1107C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 13 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1113C>G gyrB_c.1113C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1119C>G gyrB_c.1119C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1119C>T gyrB_c.1119C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 11 4002 18524 0 0 0.000921334294721226 0.99940652818991 0.998938363693644 0.999703704968061 0 0 0.284914152918154 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.84512569595635 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 1742 6636 0 0 0.00211537106925253 0.999397590361445 0.998458316867766 0.999835840034063 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 5.77543554850383 NA NA NA NA NA NA 36 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.111C>T gyrB_c.111C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 20.3050873563561 NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1131C>T gyrB_c.1131C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1152G>C gyrB_c.1152G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1158G>A gyrB_c.1158G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1167C>T gyrB_c.1167C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 31 4002 18504 0 0 0.000921334294721226 0.998327488535203 0.997626836277036 0.998863335475117 0 0 0.11218874692237 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.58462099865308 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 10 1742 6630 0 0 0.00211537106925253 0.998493975903614 0.99723211779991 0.999277574112589 0 0 0.30849710781876 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.69989001249307 NA NA NA NA NA NA 202 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1200C>G gyrB_c.1200C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 11.2104345733627 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1209G>A gyrB_c.1209G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1209G>T gyrB_c.1209G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 4001 18533 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999892096034529 0.999610268708724 0.999986932062044 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.31604598850287 0.0392471382871788 44.494064095996 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.120C>T gyrB_c.120C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01683899052165 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1215C>T gyrB_c.1215C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 20.3050873563561 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1218T>A gyrB_c.1218T>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 20.3050873563561 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1224C>T gyrB_c.1224C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 11.2104345733627 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1242G>A gyrB_c.1242G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1248C>G gyrB_c.1248C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1275G>A gyrB_c.1275G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1302C>T gyrB_c.1302C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1305C>A gyrB_c.1305C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1311A>G gyrB_c.1311A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1312T>C gyrB_c.1312T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1320C>T gyrB_c.1320C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1324C>T gyrB_c.1324C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1335C>T gyrB_c.1335C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1338T>C gyrB_c.1338T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1341C>T gyrB_c.1341C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1344G>A gyrB_c.1344G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 4.63234191452137 0.0589984289392935 362.546724531758 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1356G>A gyrB_c.1356G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1359C>T gyrB_c.1359C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.138T>C gyrB_c.138T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.-13G>C gyrB_c.-13G>C 1 upstream_gene_variant 5227 1 0 0 0 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1366 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Moxifloxacin gyrB c.1425C>T gyrB_c.1425C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1441C>T gyrB_c.1441C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 6 4002 18529 0 0 0.000921334294721226 0.999676288103587 0.999295549654279 0.999881194471086 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.93385874811763 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.22785363871091 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1446C>T gyrB_c.1446C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.144G>A gyrB_c.144G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 6 1 3996 18534 0.00149925037481259 0.000550390926465245 0.00326035944931569 0.999946048017264 0.999699435860871 0.999998634054993 0.857142857142857 0.421276802956804 0.996389703138099 NA NA NA NA NA NA NA NA NA NA NA NA False False 27.8288288288288 3.3741847349771 1271.09641004595 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 6 1 1736 6639 0.00344431687715269 0.00126502019745104 0.00748164597286304 0.999849397590361 0.999161185884076 0.99999618708438 0.857142857142857 0.421276802956804 0.996389703138099 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 22.9458525345622 2.77982437027815 1049.59655105486 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1458C>T gyrB_c.1458C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1476C>G gyrB_c.1476C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1476C>T gyrB_c.1476C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1482C>T gyrB_c.1482C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 12 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1485G>T gyrB_c.1485G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1488G>A gyrB_c.1488G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 20.3050873563561 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1489C>T gyrB_c.1489C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1497C>T gyrB_c.1497C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 11 4002 18524 0 0 0.000921334294721226 0.99940652818991 0.998938363693644 0.999703704968061 0 0 0.284914152918154 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.84512569595635 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 5 1742 6635 0 0 0.00211537106925253 0.999246987951807 0.99824360331506 0.999755455269461 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.16029237021718 NA NA NA NA NA NA 15 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1506T>C gyrB_c.1506T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1506T>G gyrB_c.1506T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 4.63234191452137 0.0589984289392935 362.546724531758 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.150C>A gyrB_c.150C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1512G>T gyrB_c.1512G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1524G>C gyrB_c.1524G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1527G>A gyrB_c.1527G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1533C>G gyrB_c.1533C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1536G>C gyrB_c.1536G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1554T>C gyrB_c.1554T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1563G>A gyrB_c.1563G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1566G>C gyrB_c.1566G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1566G>T gyrB_c.1566G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1569C>G gyrB_c.1569C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 4.63234191452137 0.0589984289392935 362.546724531758 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1569C>T gyrB_c.1569C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1572C>T gyrB_c.1572C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1575C>T gyrB_c.1575C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1578G>A gyrB_c.1578G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 15 56 3987 18479 0.00374812593703148 0.00209926869551387 0.00617444031818382 0.996978688966819 0.996078346752294 0.997716951542235 0.211267605633802 0.123340590872648 0.324402660905652 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.24146780608405 0.651385253411154 2.22824150693049 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 13 35 1729 6605 0.00746268656716417 0.0039793748824478 0.0127276127095834 0.99472891566265 0.992676751673434 0.996325831722078 0.270833333333333 0.152781868608216 0.418456365326188 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.41890440386681 0.687292831256958 2.75592065044457 NA NA NA NA NA NA 93 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1585C>T gyrB_c.1585C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1593C>T gyrB_c.1593C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1602T>C gyrB_c.1602T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1611C>A gyrB_c.1611C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1617T>C gyrB_c.1617T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 4.63234191452137 0.0589984289392935 362.546724531758 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1620T>C gyrB_c.1620T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 9 4002 18526 0 0 0.000921334294721226 0.999514432155381 0.999078442003892 0.999777944189974 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.34636960420997 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 1742 6636 0 0 0.00211537106925253 0.999397590361445 0.998458316867766 0.999835840034063 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 5.77543554850383 NA NA NA NA NA NA 17 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1623C>G gyrB_c.1623C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1632G>A gyrB_c.1632G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1638G>A gyrB_c.1638G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1639T>C gyrB_c.1639T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 11.2104345733627 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1642T>C gyrB_c.1642T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1668C>A gyrB_c.1668C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1674C>T gyrB_c.1674C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1680T>C gyrB_c.1680T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 4002 18530 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.05471226039473 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.22785363871091 NA NA NA NA NA NA 15 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1683G>A gyrB_c.1683G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1683G>C gyrB_c.1683G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1687T>C gyrB_c.1687T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1692A>G gyrB_c.1692A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 4.63234191452137 0.0589984289392935 362.546724531758 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1698G>A gyrB_c.1698G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1707C>T gyrB_c.1707C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1713C>G gyrB_c.1713C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1725C>G gyrB_c.1725C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1725C>T gyrB_c.1725C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1734G>A gyrB_c.1734G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1740C>T gyrB_c.1740C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1773G>C gyrB_c.1773G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1803C>T gyrB_c.1803C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1815C>T gyrB_c.1815C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1818C>T gyrB_c.1818C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1821T>C gyrB_c.1821T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1854T>C gyrB_c.1854T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1861T>C gyrB_c.1861T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1887G>C gyrB_c.1887G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1914G>C gyrB_c.1914G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 3 4001 18532 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999838144051794 0.999527061819887 0.99996662016845 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.5439473464967 0.0294026895471131 19.2327580431529 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 1741 6639 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999849397590361 0.999161185884076 0.99999618708438 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.81332567489948 0.0485516368820753 298.645085154332 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1917C>T gyrB_c.1917C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 11.2104345733627 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1920C>T gyrB_c.1920C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 11.2104345733627 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1923C>T gyrB_c.1923C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 20.3050873563561 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1947C>G gyrB_c.1947C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1947C>T gyrB_c.1947C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1953G>A gyrB_c.1953G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1959C>A gyrB_c.1959C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1980C>T gyrB_c.1980C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1983C>T gyrB_c.1983C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 8 419 3994 18116 0.00199900049975012 0.000863409206250761 0.003935008292197 0.977394119233882 0.975150816268778 0.979485863942188 0.018735362997658 0.00812244626963419 0.0365811428460809 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.086602457385362 0.0371145410818975 0.172428394614108 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 3 199 1739 6441 0.00172215843857634 0.000355291378803123 0.00502455256196275 0.970030120481927 0.965641692898902 0.973998998945442 0.0148514851485148 0.00307326789839701 0.0427865960229049 NA NA NA NA NA NA NA NA NA NA NA NA False True 1 1 1 0 0 0 0 0.0558369767179774 0.0114174328854331 0.165921943217749 NA NA NA NA NA NA 301 5) Not assoc w R Now listed Silent mutation no 0 +Moxifloxacin gyrB c.198C>T gyrB_c.198C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.1995C>T gyrB_c.1995C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.-19T>C gyrB_c.-19T>C 1 upstream_gene_variant 5221 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB c.-1C>G gyrB_c.-1C>G 1 upstream_gene_variant 5239 1 7 0 7 0 7 4002 18528 0 0 0.000921334294721226 0.999622336120852 0.999222023868969 0.999848146482689 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 3.21342445526953 0.615309777551834 178.5 1798 False False 0 0 3.21342445526953 0 0 0.000921334294721226 0.999622336120852 0.999222023868969 0.999848146482689 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 1742 6634 0 0 0.00211537106925253 0.999096385542168 0.998034257105878 0.999668319522948 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.23733664541029 0.355668965817841 60.5 886 False False 0 0 0 0 0 0 0 0 0 3.23733664541029 0 0 0.00211537106925253 0.999096385542168 0.998034257105878 0.999668319522948 3 3) Uncertain significance No change no 1 +Moxifloxacin gyrB c.-1C>T gyrB_c.-1C>T 1 upstream_gene_variant 5239 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1393 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 681 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 3 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB c.2001C>G gyrB_c.2001C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.2017C>T gyrB_c.2017C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.2019G>C gyrB_c.2019G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.2027A>G gyrB_c.2027A>G 1 stop_retained_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.205C>T gyrB_c.205C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 3999 18535 0.000749625187406296 0.000154617422592445 0.00218914487959466 1 0.999800997443015 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.91440039171731 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 1740 6640 0.00114810562571756 0.000139071172424607 0.00414113746933503 1 0.999444600156968 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.716065670156237 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.213G>A gyrB_c.213G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.219C>A gyrB_c.219C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.231C>T gyrB_c.231C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 8 0 3994 18535 0.00199900049975012 0.000863409206250761 0.003935008292197 1 0.999800997443015 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 7.91458023178468 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 1739 6640 0.00172215843857634 0.000355291378803123 0.00502455256196275 1 0.999444600156968 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.57612016206794 Inf NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.-26C>G gyrB_c.-26C>G 1 upstream_gene_variant 5214 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 2 3) Uncertain significance No change no 1 +Moxifloxacin gyrB c.270C>T gyrB_c.270C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.273C>G gyrB_c.273C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.285C>A gyrB_c.285C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 4002 18530 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.05471226039473 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 1742 6636 0 0 0.00211537106925253 0.999397590361445 0.998458316867766 0.999835840034063 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 5.77543554850383 NA NA NA NA NA NA 18 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.285C>G gyrB_c.285C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.288C>T gyrB_c.288C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.291C>T gyrB_c.291C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 8 4002 18527 0 0 0.000921334294721226 0.999568384138117 0.999149722782159 0.999813641077243 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.7132714326819 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 6 1742 6634 0 0 0.00211537106925253 0.999096385542168 0.998034257105878 0.999668319522948 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.23733664541029 NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.307C>T gyrB_c.307C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 11.2104345733627 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 20.3050873563561 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.309A>G gyrB_c.309A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.30C>T gyrB_c.30C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.315C>G gyrB_c.315C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.339G>C gyrB_c.339G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.339G>T gyrB_c.339G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.351T>G gyrB_c.351T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.366C>T gyrB_c.366C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.372C>T gyrB_c.372C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.-37C>T gyrB_c.-37C>T 1 upstream_gene_variant 5203 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB c.-39A>G gyrB_c.-39A>G 1 upstream_gene_variant 5201 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB c.435G>A gyrB_c.435G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.462A>G gyrB_c.462A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.468G>T gyrB_c.468G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.471C>T gyrB_c.471C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.474C>G gyrB_c.474C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 11.2104345733627 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.480A>G gyrB_c.480A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 4.63234191452137 0.0589984289392935 362.546724531758 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 1741 6639 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999849397590361 0.999161185884076 0.99999618708438 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.81332567489948 0.0485516368820753 298.645085154332 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.492C>T gyrB_c.492C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 11.2104345733627 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.22785363871091 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.495G>A gyrB_c.495G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.-4G>A gyrB_c.-4G>A 1 upstream_gene_variant 5236 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrB c.513G>A gyrB_c.513G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 32 4002 18503 0 0 0.000921334294721226 0.998273536552468 0.99756361507547 0.998818809829878 0 0 0.108881160679352 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.56523868384517 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 10 1742 6630 0 0 0.00211537106925253 0.998493975903614 0.99723211779991 0.999277574112589 0 0 0.30849710781876 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.69989001249307 NA NA NA NA NA NA 208 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.51C>T gyrB_c.51C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.525C>G gyrB_c.525C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01683899052165 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.528C>T gyrB_c.528C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.-52C>T gyrB_c.-52C>T 1 upstream_gene_variant 5188 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Moxifloxacin gyrB c.531C>G gyrB_c.531C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.531C>T gyrB_c.531C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 4002 18530 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.05471226039473 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 16 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.534T>G gyrB_c.534T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.-53C>G gyrB_c.-53C>G 1 upstream_gene_variant 5187 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB c.540C>T gyrB_c.540C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.546C>G gyrB_c.546C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 4.63234191452137 0.0589984289392935 362.546724531758 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.549G>A gyrB_c.549G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.54C>T gyrB_c.54C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.-54C>T gyrB_c.-54C>T 1 upstream_gene_variant 5186 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrB c.-55C>T gyrB_c.-55C>T 1 upstream_gene_variant 5185 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB c.-55delC gyrB_c.-55delC 1 upstream_gene_variant 5184 1 7 0 7 0 7 4002 18528 0 0 0.000921334294721226 0.999622336120852 0.999222023868969 0.999848146482689 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 3.21342445526953 0.615309777551834 178.5 1798 False False 0 0 3.21342445526953 0 0 0.000921334294721226 0.999622336120852 0.999222023868969 0.999848146482689 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 7 1742 6633 0 0 0.00211537106925253 0.99894578313253 0.997829124235982 0.999576048424705 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 2.64457250939033 0.357314381934628 65 886 False False 0 0 0 0 0 0 0 0 0 2.64457250939033 0 0 0.00211537106925253 0.99894578313253 0.997829124235982 0.999576048424705 9 3) Uncertain significance No change no 1 +Moxifloxacin gyrB c.561C>T gyrB_c.561C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.57T>C gyrB_c.57T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.580C>T gyrB_c.580C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.582G>C gyrB_c.582G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.-58C>G gyrB_c.-58C>G 1 upstream_gene_variant 5182 1 2 0 2 1 3 4001 18532 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999838144051794 0.999527061819887 0.99996662016845 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 24.6676166728131 1 732.5 1798 False False 1.5439473464967 0.0294026895471131 19.2327580431529 0 0 0.000921564464586207 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB c.-5G>A gyrB_c.-5G>A 1 upstream_gene_variant 5235 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB c.-60_-59insG gyrB_c.-60_-59insG 1 upstream_gene_variant 5180 0 0 0 0 3 0 3999 18535 0.000749625187406296 0.000154617422592445 0.00218914487959466 1 0.999800997443015 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1334 1798 False False Inf 1.91440039171731 Inf 0 0 0.000922025149498025 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 1739 6640 0.00172215843857634 0.000355291378803123 0.00502455256196275 1 0.999444600156968 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 643 886 False False 0 0 0 0 0 0 0 Inf 1.57612016206794 Inf 0 0 0.00211901648886052 1 0.999444600156968 1 2 3) Uncertain significance No change no 1 +Moxifloxacin gyrB c.-60_-59insGC gyrB_c.-60_-59insGC 1 upstream_gene_variant 5180 0 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1375 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 669 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB c.603C>T gyrB_c.603C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 11.2104345733627 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.22785363871091 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.609G>A gyrB_c.609G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.60C>A gyrB_c.60C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.60C>T gyrB_c.60C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.-60T>C gyrB_c.-60T>C 1 upstream_gene_variant 5180 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 3 3) Uncertain significance No change no 1 +Moxifloxacin gyrB c.-60T>G gyrB_c.-60T>G 1 upstream_gene_variant 5180 0 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1378 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB c.624G>T gyrB_c.624G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 4002 18530 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.05471226039473 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.651G>A gyrB_c.651G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.669C>G gyrB_c.669C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.66G>C gyrB_c.66G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.-66G>T gyrB_c.-66G>T 1 upstream_gene_variant 5174 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB c.678C>T gyrB_c.678C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 4 4001 18531 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999784192069058 0.999447539013843 0.999941196572055 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.15789802549362 0.0235059760051305 11.7081385811536 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 1741 6639 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999849397590361 0.999161185884076 0.99999618708438 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.81332567489948 0.0485516368820753 298.645085154332 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.67C>T gyrB_c.67C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.693G>A gyrB_c.693G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.-6C>T gyrB_c.-6C>T 1 upstream_gene_variant 5234 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB c.708C>G gyrB_c.708C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.720C>G gyrB_c.720C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.726A>G gyrB_c.726A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 8 6 3994 18529 0.00199900049975012 0.000863409206250761 0.003935008292197 0.999676288103587 0.999295549654279 0.999881194471086 0.571428571428571 0.288609400038307 0.823388910017882 NA NA NA NA NA NA NA NA NA NA NA NA False False 6.18561175095977 1.88070956380815 21.6379253942151 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 6 2 1736 6638 0.00344431687715269 0.00126502019745104 0.00748164597286304 0.999698795180722 0.998912372612698 0.9999635206173 0.75 0.349144205587175 0.968145973750055 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 11.471198156682 2.04817072388066 116.349100429339 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.72G>A gyrB_c.72G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.747C>A gyrB_c.747C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.75C>T gyrB_c.75C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.771G>C gyrB_c.771G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.780C>T gyrB_c.780C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.789C>T gyrB_c.789C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 8 4001 18527 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999568384138117 0.999149722782159 0.999813641077243 0.111111111111111 0.00280913674659921 0.482496514917337 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.578824043989002 0.0130447733848513 4.31945136015563 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 20.3050873563561 NA NA NA NA NA NA 12 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.78C>A gyrB_c.78C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 20.3050873563561 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.-78G>A gyrB_c.-78G>A 1 upstream_gene_variant 5162 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB c.798C>G gyrB_c.798C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 4002 18530 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.05471226039473 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 1742 6636 0 0 0.00211537106925253 0.999397590361445 0.998458316867766 0.999835840034063 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 5.77543554850383 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.807C>T gyrB_c.807C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.-80C>A gyrB_c.-80C>A 1 upstream_gene_variant 5160 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB c.843G>A gyrB_c.843G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.-84G>A gyrB_c.-84G>A 1 upstream_gene_variant 5156 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB c.852G>A gyrB_c.852G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.-85delG gyrB_c.-85delG 1 upstream_gene_variant 5154 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB c.861G>A gyrB_c.861G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.867C>T gyrB_c.867C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 11.2104345733627 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 20.3050873563561 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.870G>A gyrB_c.870G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 13 4002 18522 0 0 0.000921334294721226 0.99929862422444 0.998800924705247 0.999626495767062 0 0 0.24705263800047 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.51934003385999 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 7 1742 6633 0 0 0.00211537106925253 0.99894578313253 0.997829124235982 0.999576048424705 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.64457250939033 NA NA NA NA NA NA 50 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.-87C>G gyrB_c.-87C>G 1 upstream_gene_variant 5153 1 2 0 2 0 5 4002 18530 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 0 0 0.521823750104981 0 0 0.841886116991581 0 0 0.521823750104981 0 0 24.6587956444838 1 732.5 1798 False False 0 0 5.05471226039473 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB c.885C>T gyrB_c.885C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 31 444 3971 18091 0.00774612693653173 0.00526901033494707 0.0109771345825656 0.976045319665497 0.973740900039438 0.978198677588174 0.0652631578947368 0.0447703377274895 0.091359553025585 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.318083696892561 0.213178606546705 0.458964715949881 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 11 218 1731 6422 0.00631458094144661 0.00315630578799124 0.0112703796091745 0.967168674698795 0.96259695143815 0.971323821798304 0.0480349344978165 0.0242195536843081 0.0843208354621304 NA NA NA NA NA NA NA NA NA NA NA NA False True 1 1 1 0 0 0 0 0.187201543362006 0.0918717359130024 0.342724509351737 NA NA NA NA NA NA 643 5) Not assoc w R Now listed Silent mutation no 0 +Moxifloxacin gyrB c.-89C>A gyrB_c.-89C>A 1 upstream_gene_variant 5151 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB c.903G>C gyrB_c.903G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.915C>G gyrB_c.915C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.915C>T gyrB_c.915C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 11.2104345733627 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.927C>T gyrB_c.927C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.93C>A gyrB_c.93C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.93C>T gyrB_c.93C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 14 11 3988 18524 0.00349825087456271 0.00191380546833921 0.00586251148053981 0.99940652818991 0.998938363693644 0.999703704968061 0.56 0.349281633991335 0.755976334852791 NA NA NA NA NA NA NA NA NA NA NA NA False False 5.91173520561685 2.4908551375558 14.3999836733402 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 8 7 1734 6633 0.00459242250287026 0.00198470392380438 0.00902874874953196 0.99894578313253 0.997829124235982 0.999576048424705 0.533333333333333 0.265861347277396 0.787333270480692 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.37172516065249 1.3828708794126 14.1805666101106 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.-93T>C gyrB_c.-93T>C 1 upstream_gene_variant 5147 1 2 0 2 1 5 4001 18530 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999730240086323 0.999370583585258 0.99991240407437 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.841886116991581 0 0 0.521823750104981 0 0 24.6649561389967 1 198.5 1798 False False 0.926268432891777 0.0195789744788398 8.28271147593069 0 0 0.000921564464586207 0.999730240086323 0.999370583585258 0.99991240407437 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrB c.945C>A gyrB_c.945C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.945C>T gyrB_c.945C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 20.3050873563561 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.-95G>C gyrB_c.-95G>C 1 upstream_gene_variant 5145 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB c.963C>T gyrB_c.963C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.969G>A gyrB_c.969G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 5 5 3997 18530 0.00124937531234382 0.000405789275012681 0.0029131967931525 0.999730240086323 0.999370583585258 0.99991240407437 0.5 0.187086028447398 0.812913971552601 NA NA NA NA NA NA NA NA NA NA NA NA False False 4.63597698273705 1.06631671873539 20.1518372164177 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.975G>A gyrB_c.975G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.984G>C gyrB_c.984G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.984G>T gyrB_c.984G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.-98G>T gyrB_c.-98G>T 1 upstream_gene_variant 5142 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1360 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB c.999G>A gyrB_c.999G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin gyrB c.-9A>G gyrB_c.-9A>G 1 upstream_gene_variant 5231 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Ala115Val gyrB_p.Ala115Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Ala130Ser gyrB_p.Ala130Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 16 0 16 0 17 4002 18518 0 0 0.000921334294721226 0.999082816293498 0.998531904853251 0.9994656187862 0 0 0.195064322969093 0 0 0.205907214207822 0 0 0.195064322969093 0 0 1.20045193163416 0.0934671654662 48 1798 False False 0 0 1.12191532231395 0 0 0.000921334294721226 0.999082816293498 0.998531904853251 0.9994656187862 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 18 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Ala162Glu gyrB_p.Ala162Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Ala162Ser gyrB_p.Ala162Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 11.2104345733627 1 732.5 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 10 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Ala175Thr gyrB_p.Ala175Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 4 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Ala191Asp gyrB_p.Ala191Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Ala233Gly gyrB_p.Ala233Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1339 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Ala233Pro gyrB_p.Ala233Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 5 0 3997 18535 0.00124937531234382 0.000405789275012681 0.0029131967931525 1 0.999800997443015 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 1367 1798 False False Inf 4.24707467079201 Inf 0 0 0.00092248629522778 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 1740 6640 0.00114810562571756 0.000139071172424607 0.00414113746933503 1 0.999444600156968 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 663 886 False False 0 0 0 0 0 0 0 Inf 0.716065670156237 Inf 0 0 0.00211779995375925 1 0.999444600156968 1 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Ala233Val gyrB_p.Ala233Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Ala237Gly gyrB_p.Ala237Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Ala238Gly gyrB_p.Ala238Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1351 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Ala238Thr gyrB_p.Ala238Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Ala242Thr gyrB_p.Ala242Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Ala2Ser gyrB_p.Ala2Ser 1 missense_variant (see "Genomic_coordinates" sheet) 2 2 1 1 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 4.63234191452137 0.0589984289392935 362.546724531758 0.323623032303333 101.5 1798 False False 4.63234191452137 0.0589984289392935 362.546724531758 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Ala332Val gyrB_p.Ala332Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Ala355Thr gyrB_p.Ala355Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Ala398Val gyrB_p.Ala398Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 8 4002 18527 0 0 0.000921334294721226 0.999568384138117 0.999149722782159 0.999813641077243 0 0 0.369416647552819 0 0 0.409616397225003 0 0 0.369416647552819 0 0 3.2132507580148 0.615314823004161 181.5 1798 False False 0 0 2.7132714326819 0 0 0.000921334294721226 0.999568384138117 0.999149722782159 0.999813641077243 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 1742 6636 0 0 0.00211537106925253 0.999397590361445 0.998458316867766 0.999835840034063 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.22646396172322 1 345 886 False False 0 0 0 0 0 0 0 0 0 5.77543554850383 0 0 0.00211537106925253 0.999397590361445 0.998458316867766 0.999835840034063 7 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Ala403Ser gyrB_p.Ala403Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 31 0 31 0 60 4002 18475 0 0 0.000921334294721226 0.996762881035878 0.99583512406118 0.99752885572536 0 0 0.0596294922861668 0 0 0.11218874692237 0 0 0.0596294922861668 0 0 0.583704171647908 0.00376400590854128 26 1798 False False 0 0 0.29290372992055 0 0 0.000921334294721226 0.996762881035878 0.99583512406118 0.99752885572536 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 18 1742 6622 0 0 0.00211537106925253 0.997289156626506 0.995719069710777 0.998392615571978 0 0 0.185301968137852 0 0 0.409616397225003 0 0 0.185301968137852 0 0 2.64018857323143 0.357330382655726 68 886 False False 0 0 0 0 0 0 0 0 0 0.865728057987466 0 0 0.00211537106925253 0.997289156626506 0.995719069710777 0.998392615571978 400 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Ala403Val gyrB_p.Ala403Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Ala423Val gyrB_p.Ala423Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 11.2104345733627 1 732.5 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 21 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Ala432Val gyrB_p.Ala432Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 2 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Ala467Thr gyrB_p.Ala467Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1390 1798 False False 4.63234191452137 0.0589984289392935 362.546724531758 0 0 0.000921564464586207 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 679 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Ala504Thr gyrB_p.Ala504Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 9 3 3993 18532 0.00224887556221889 0.00102882864885218 0.00426475484372027 0.999838144051794 0.999527061819887 0.99996662016845 0.75 0.42814153812181 0.945139355472007 0 0 0.841886116991581 0 0 0.707598226178713 0 0 24.716333493781 1 732.5 1798 False False 13.923365890308 3.47212981098601 79.9610730634449 0 0 0.000923409971909585 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 1 1739 6639 0.00172215843857634 0.000355291378803123 0.00502455256196275 0.999849397590361 0.999161185884076 0.99999618708438 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 148.569802390555 1 345 886 False False 0 0 0 0 0 0 0 11.4531339850488 0.918610489831449 599.171952973569 0 0 0.00211901648886052 0.999849397590361 0.999161185884076 0.99999618708438 9 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Ala504Val gyrB_p.Ala504Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 2 5 14 10 3988 18525 0.00349825087456271 0.00191380546833921 0.00586251148053981 0.999460480172646 0.999008028394192 0.999741249920483 0.583333333333333 0.366430645656362 0.778903094653321 0.285714285714285 0.0366925661760855 0.709579136262657 0.166666666666666 0.0208625254600923 0.484137748685967 1.858074222668 0.176858603790157 11.3549572375056 0.359748870344567 107 1798 False False 6.50325977933801 2.68403308889579 16.3704331449372 0.00050125313283208 6.07098454145612e-05 0.00180951354570486 0.999460480172646 0.999008028394192 0.999741249920483 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 7 1 1735 6639 0.00401836969001148 0.00161707270669399 0.00826174702450177 0.999849397590361 0.999161185884076 0.99999618708438 0.875 0.473490329124793 0.996840276468748 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 3.82651296829971 0.0487194430818824 299.675123229701 0.371581063165547 69 886 False False 0 0 0 0 0 0 0 26.7855907780979 3.43585342243337 1199.61710461743 0.000576036866359447 1.4583884428484e-05 0.00320524921924429 0.999849397590361 0.999161185884076 0.99999618708438 40 Assoc w RI FQ cross-resistance 2) Assoc w R - Interim Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance) No change yes FQ X-R F 1 +Moxifloxacin gyrB p.Ala508Val gyrB_p.Ala508Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Ala564Thr gyrB_p.Ala564Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Ala593Val gyrB_p.Ala593Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 7.01683899052165 1 732.5 1798 False False 0 0 7.01683899052165 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 1742 6636 0 0 0.00211537106925253 0.999397590361445 0.998458316867766 0.999835840034063 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.77543554850383 0.5866324014095 78.5 886 False False 0 0 0 0 0 0 0 0 0 5.77543554850383 0 0 0.00211537106925253 0.999397590361445 0.998458316867766 0.999835840034063 205 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Ala597Thr gyrB_p.Ala597Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1377 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Ala618Asp gyrB_p.Ala618Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.118754661339467 Inf 0.177574655011758 72.5 1798 False False Inf 0.118754661339467 Inf 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Ala618Thr gyrB_p.Ala618Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 1 3999 18534 0.000749625187406296 0.000154617422592445 0.00218914487959466 0.999946048017264 0.999699435860871 0.999998634054993 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 180.255144665755 1 732.5 1798 False False 13.9039759939985 1.11586102000443 726.694777866907 0 0 0.000922025149498025 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 1741 6639 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999849397590361 0.999161185884076 0.99999618708438 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 148.399526333966 1 596 886 False False 0 0 0 0 0 0 0 3.81332567489948 0.0485516368820753 298.645085154332 0 0 0.00211658481469046 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Ala643Asp gyrB_p.Ala643Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1379 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 672 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Ala644Asp gyrB_p.Ala644Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 4001 18532 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999838144051794 0.999527061819887 0.99996662016845 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 11.2132358700375 1 732.5 1798 False False 1.5439473464967 0.0294026895471131 19.2327580431529 0 0 0.000921564464586207 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 6 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Ala644del gyrB_p.Ala644del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 8 0 8 2 10 4000 18525 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 0.999460480172646 0.999008028394192 0.999741249920483 0.166666666666666 0.0208625254600923 0.484137748685967 0 0 0.369416647552819 0 0 0.30849710781876 0 0 2.71433538336595 0.36516968079635 110 1798 False False 0.92625 0.0986414165293809 4.34938018257845 0 0 0.000921794749483055 0.999460480172646 0.999008028394192 0.999741249920483 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 148.292249815985 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 55 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Ala78Gly gyrB_p.Ala78Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Ala78Val gyrB_p.Ala78Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Ala87Gly gyrB_p.Ala87Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Ala90Gly gyrB_p.Ala90Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 4002 18529 0 0 0.000921334294721226 0.999676288103587 0.999295549654279 0.999881194471086 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.93385874811763 0.599069212767884 166.5 1798 False False 0 0 3.93385874811763 0 0 0.000921334294721226 0.999676288103587 0.999295549654279 0.999881194471086 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 3 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Ala90Thr gyrB_p.Ala90Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Arg192His gyrB_p.Arg192His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Arg212Thr gyrB_p.Arg212Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1381 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 673 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Arg446Cys gyrB_p.Arg446Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 21 7 14 9 15 3993 18520 0.00224887556221889 0.00102882864885218 0.00426475484372027 0.999190720258969 0.998665566860464 0.999546983769752 0.375 0.187992928196002 0.594063615992055 0.333333333333333 0.145876942343096 0.569675482904124 0.318181818181818 0.138646521553797 0.54872442757377 2.3190583521162 0.791583889561091 6.14447800610393 0.0806086284362243 45 1798 False False 2.78287002253944 1.07292937005624 6.79333659298523 0.00175 0.000703871137584505 0.00360232411338222 0.999190720258969 0.998665566860464 0.999546983769752 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 2 4 3 4 1739 6636 0.00172215843857634 0.000355291378803123 0.00502455256196275 0.999397590361445 0.998458316867766 0.999835840034063 0.428571428571428 0.0989882784425078 0.815948432359917 0.333333333333333 0.0432718682927417 0.777221904496487 0.333333333333333 0.0432718682927417 0.777221904496487 1.90799309948246 0.172433685515143 13.3246425244797 0.610830655612367 95 886 False False 0 0 0 0 0 0 0 2.86198964922369 0.41878325287878 16.9296564860373 0.00114876507754164 0.00013915106987271 0.00414351249733724 0.999397590361445 0.998458316867766 0.999835840034063 20 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Arg446Gly gyrB_p.Arg446Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1385 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Arg446His gyrB_p.Arg446His 1 missense_variant (see "Genomic_coordinates" sheet) 1 10 1 9 1 10 4001 18525 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999460480172646 0.999008028394192 0.999741249920483 0.0909090909090909 0.00229897221381426 0.412779916988382 0.1 0.00252857854446178 0.445016117028195 0.0909090909090909 0.00229897221381426 0.412779916988382 0.514454719653419 0.0117376963137265 3.71472446467469 1 732.5 1798 False False 0.463009247688078 0.0106697037948228 3.25640205836453 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999460480172646 0.999008028394192 0.999741249920483 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.22785363871091 1 345 886 False False 0 0 0 0 0 0 0 0 0 9.22785363871091 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 9 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Arg446Leu gyrB_p.Arg446Leu 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 0 1 2 2 4000 18533 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 0.999892096034529 0.999610268708724 0.999986932062044 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 180.20051244703 1 732.5 1798 False False 4.63325 0.335715582549978 63.989229087488 0 0 0.000921794749483055 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Arg451His gyrB_p.Arg451His 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1374 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Arg492Ser gyrB_p.Arg492Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1361 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Arg495Gln gyrB_p.Arg495Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Arg523Cys gyrB_p.Arg523Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Arg523Ser gyrB_p.Arg523Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Arg553Gly gyrB_p.Arg553Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.118754661339467 Inf 0.177574655011758 72.5 1798 False False Inf 0.118754661339467 Inf 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Arg553Trp gyrB_p.Arg553Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Arg575His gyrB_p.Arg575His 1 missense_variant (see "Genomic_coordinates" sheet) 1 25 1 24 1 29 4001 18506 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.998435392500674 0.997753729474072 0.998951915188256 0.0333333333333333 0.000843570926630479 0.172169455633412 0.04 0.00101219969931084 0.203516913922414 0.0333333333333333 0.000843570926630479 0.172169455633412 0.192722652670165 0.00468894741382849 1.18262693289623 0.109846875001396 49 1798 False False 0.159494609106344 0.00390780923955051 0.962585803986783 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.998435392500674 0.997753729474072 0.998951915188256 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 1 10 1 13 1741 6627 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.998042168674698 0.996654375813144 0.998957138349653 0.0714285714285714 0.00180678065912538 0.338684489931821 0.0909090909090909 0.00229897221381426 0.412779916988382 0.0714285714285714 0.00180678065912538 0.338684489931821 0.380643308443423 0.00876957648183799 2.67913063561127 0.478119836448059 71 886 False False 0 0 0 0 0 0 0 0.292802544956479 0.00688946499922697 1.95210013907648 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.998042168674698 0.996654375813144 0.998957138349653 24 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Arg587Gly gyrB_p.Arg587Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 180.110710654533 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 670 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Arg634Leu gyrB_p.Arg634Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Arg665Cys gyrB_p.Arg665Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 4 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Asn207Asp gyrB_p.Asn207Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Asn499Asp gyrB_p.Asn499Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 11 9 2 12 5 3990 18530 0.00299850074962518 0.00155029923838043 0.00523191326268615 0.999730240086323 0.999370583585258 0.99991240407437 0.705882352941176 0.440417281245662 0.89686448562968 0.818181818181818 0.482244147639827 0.97716880170004 0.642857142857142 0.351380110615991 0.87240157014084 20.8984962406015 4.32253388389427 198.323843102555 6.74482189089499e-06 18 1798 True False 11.1458646616541 3.65171809594828 40.4126162903944 0.00225056264066016 0.00102960083866322 0.00426795097335377 0.999730240086323 0.999370583585258 0.99991240407437 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance 1 3 2 1 3 3 1739 6637 0.00172215843857634 0.000355291378803123 0.00502455256196275 0.999548192771084 0.998680200855815 0.999906816794257 0.5 0.118117248757025 0.881882751242974 0.666666666666666 0.0942993240502461 0.991596241340387 0.4 0.0527449505263169 0.853367200365326 7.63312248418631 0.397038896397108 449.053289980291 0.111543696684657 26 886 False False 0 0 0 0 0 0 0 3.81656124209315 0.510625108255601 28.5261585470587 0.00114876507754164 0.00013915106987271 0.00414351249733724 0.999548192771084 0.998680200855815 0.999906816794257 21 Assoc w RI Marker of R Evidence from ALL dataset only 2) Assoc w R - Interim Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance) No change yes ALL only F 1 +Moxifloxacin gyrB p.Asn499Ile gyrB_p.Asn499Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 4001 18533 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999892096034529 0.999610268708724 0.999986932062044 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 180.155600359953 1 732.5 1798 False False 2.31604598850287 0.0392471382871788 44.494064095996 0 0 0.000921564464586207 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Asn499Lys gyrB_p.Asn499Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 3 0 5 2 3997 18533 0.00124937531234382 0.000405789275012681 0.0029131967931525 0.999892096034529 0.999610268708724 0.999986932062044 0.714285714285714 0.290420863737342 0.963307433823914 1 0.292401773821286 1 0.6 0.146632799634673 0.947255049473683 Inf 1.91515117594635 Inf 0.0055905554374167 27 1798 False False 11.5918188641481 1.89664818799014 121.857791568803 0.00075 0.000154694744658044 0.00219023866287519 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 3 1 1739 6639 0.00172215843857634 0.000355291378803123 0.00502455256196275 0.999849397590361 0.999161185884076 0.99999618708438 0.75 0.194120449683243 0.99369053679029 1 0.158113883008419 1 0.666666666666666 0.0942993240502461 0.991596241340387 Inf 0.716369199689959 Inf 0.0431431459658351 21 886 False False 0 0 0 0 0 0 0 11.4531339850488 0.918610489831449 599.171952973569 0.00114876507754164 0.00013915106987271 0.00414351249733724 0.999849397590361 0.999161185884076 0.99999618708438 8 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Asn499Ser gyrB_p.Asn499Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 14 8 3988 18527 0.00349825087456271 0.00191380546833921 0.00586251148053981 0.999568384138117 0.999149722782159 0.999813641077243 0.636363636363636 0.406576668825646 0.828020562353667 0 0 0.409616397225003 0 0 0.369416647552819 0 0 3.22455314091613 0.614989186050902 174 1798 False False 8.12995235707121 3.17996123694657 22.3778067340102 0 0 0.000924567172214373 0.999568384138117 0.999149722782159 0.999813641077243 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 3 2 1739 6638 0.00172215843857634 0.000355291378803123 0.00502455256196275 0.999698795180722 0.998912372612698 0.9999635206173 0.6 0.146632799634673 0.947255049473683 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3400355540914 1 345 886 False False 0 0 0 0 0 0 0 5.72570442783208 0.655180308104634 68.6863687806226 0 0 0.00211901648886052 0.999698795180722 0.998912372612698 0.9999635206173 12 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Asn499Thr gyrB_p.Asn499Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 16 4 12 23 15 3979 18520 0.0057471264367816 0.00364656968723907 0.00861110427651623 0.999190720258969 0.998665566860464 0.999546983769752 0.605263157894736 0.433861538609529 0.759612106355964 0.25 0.0726620382528822 0.523770819896127 0.210526315789473 0.0605245377092897 0.455653081891505 1.55147859596213 0.364503617177786 5.12102346859075 0.507101990844981 123 1798 False False 7.13680154142581 3.56273594536607 14.7147287193954 0.00100426813959327 0.000273694907409062 0.00256931119491002 0.999190720258969 0.998665566860464 0.999546983769752 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 2 7 7 9 1735 6631 0.00401836969001148 0.00161707270669399 0.00826174702450177 0.998644578313253 0.997428553721748 0.999380033497835 0.4375 0.197534140532667 0.701223100916822 0.222222222222222 0.0281449734778982 0.600093573716312 0.181818181818181 0.0228311982999596 0.517755852360172 1.0919720049403 0.110570442450458 5.7425885142105 1 345 886 False False 0 0 0 0 0 0 0 2.97259045789305 0.939221451665825 8.98207868080508 0.00115141047783534 0.000139471579813546 0.00415303991450926 0.998644578313253 0.997428553721748 0.999380033497835 25 FQ cross-resistance 2) Assoc w R - Interim Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance) UP from Uncertain to AwRI yes FQ X-R F 4 +Moxifloxacin gyrB p.Asn558Asp gyrB_p.Asn558Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Asn666Ser gyrB_p.Asn666Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1332 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Asn66His gyrB_p.Asn66His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Asn66Ser gyrB_p.Asn66Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 4002 18529 0 0 0.000921334294721226 0.999676288103587 0.999295549654279 0.999881194471086 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.93385874811763 0.599069212767884 166.5 1798 False False 0 0 3.93385874811763 0 0 0.000921334294721226 0.999676288103587 0.999295549654279 0.999881194471086 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 10 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Asp110Gly gyrB_p.Asp110Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Asp112His gyrB_p.Asp112His 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 11.2104345733627 1 732.5 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 2 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Asp176Glu gyrB_p.Asp176Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Asp216Gly gyrB_p.Asp216Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Asp220Glu gyrB_p.Asp220Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Asp225Glu gyrB_p.Asp225Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Asp225Gly gyrB_p.Asp225Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Asp259Glu gyrB_p.Asp259Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 3 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Asp334Gly gyrB_p.Asp334Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 4.63234191452137 0.0589984289392935 362.546724531758 0.323623032303333 101.5 1798 False False 4.63234191452137 0.0589984289392935 362.546724531758 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Asp340Gly gyrB_p.Asp340Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1371 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 667 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Asp342Glu gyrB_p.Asp342Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 5 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Asp402Glu gyrB_p.Asp402Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Asp434Glu gyrB_p.Asp434Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Asp434Gly gyrB_p.Asp434Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 4002 18529 0 0 0.000921334294721226 0.999676288103587 0.999295549654279 0.999881194471086 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.93385874811763 0.599069212767884 166.5 1798 False False 0 0 3.93385874811763 0 0 0.000921334294721226 0.999676288103587 0.999295549654279 0.999881194471086 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 3 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Asp434His gyrB_p.Asp434His 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Asp461Ala gyrB_p.Asp461Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 4 2 3998 18533 0.000999500249875062 0.000272395196018755 0.00255712257980299 0.999892096034529 0.999610268708724 0.999986932062044 0.666666666666666 0.222778095503512 0.956728131707258 0 0 0.975 0 0 0.841886116991581 0 0 180.29040383314 1 732.5 1798 False False 9.27113556778389 1.3280388413788 102.537019047163 0 0 0.000922255664717455 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 1 1739 6639 0.00172215843857634 0.000355291378803123 0.00502455256196275 0.999849397590361 0.999161185884076 0.99999618708438 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 680 886 False False 0 0 0 0 0 0 0 11.4531339850488 0.918610489831449 599.171952973569 0 0 0.00211901648886052 0.999849397590361 0.999161185884076 0.99999618708438 2 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Asp461Asn gyrB_p.Asp461Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 25 3 22 12 24 3990 18511 0.00299850074962518 0.00155029923838043 0.00523191326268615 0.998705152414351 0.99807397809504 0.999170196040018 0.333333333333333 0.185561809825921 0.509702546651891 0.12 0.0254653966477332 0.312190307286235 0.111111111111111 0.0235274543808539 0.291586924273551 0.632638414217361 0.121173233457434 2.10734470035028 0.604500778832274 173 1798 False False 2.31967418546365 1.05603855486206 4.82754290814195 0.000751314800901577 0.000154965981971935 0.00219407552676603 0.998705152414351 0.99807397809504 0.999170196040018 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 1 8 1741 6632 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.998795180722891 0.997627413333175 0.999479705585957 0.111111111111111 0.00280913674659921 0.482496514917337 0 0 0.369416647552819 0 0 0.369416647552819 0 0 2.23404721079731 0.218654561661941 43 886 False False 0 0 0 0 0 0 0 0.47616312464101 0.010728436160514 3.55589199099794 0 0 0.00211658481469046 0.998795180722891 0.997627413333175 0.999479705585957 38 Assoc w RI FQ cross-resistance 2) Assoc w R - Interim Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance) No change yes FQ X-R F 1 +Moxifloxacin gyrB p.Asp461His gyrB_p.Asp461His 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 1 3 3 4 3999 18531 0.000749625187406296 0.000154617422592445 0.00218914487959466 0.999784192069058 0.999447539013843 0.999941196572055 0.428571428571428 0.0989882784425078 0.815948432359917 0.25 0.00630946320970987 0.805879550316756 0.2 0.00505076337946806 0.716417936118089 1.54463615903976 0.0294158035879631 19.2413426379341 0.542386829641886 124 1798 False False 3.47543135783946 0.50886084840853 20.5487304491316 0.00025 6.32943196513345e-06 0.00139211512196626 0.999784192069058 0.999447539013843 0.999941196572055 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 1741 6638 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999698795180722 0.998912372612698 0.9999635206173 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 148.377228822259 1 345 886 False False 0 0 0 0 0 0 0 1.90637564618035 0.032294587677361 36.6438813236649 0 0 0.00211658481469046 0.999698795180722 0.998912372612698 0.9999635206173 21 FQ cross-resistance 2) Assoc w R - Interim Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance) UP from Uncertain to AwRI yes FQ X-R F 4 +Moxifloxacin gyrB p.Asp461Val gyrB_p.Asp461Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 4001 18533 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999892096034529 0.999610268708724 0.999986932062044 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 180.155600359953 1 732.5 1798 False False 2.31604598850287 0.0392471382871788 44.494064095996 0 0 0.000921564464586207 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 1741 6639 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999849397590361 0.999161185884076 0.99999618708438 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 148.399526333966 1 596 886 False False 0 0 0 0 0 0 0 3.81332567489948 0.0485516368820753 298.645085154332 0 0 0.00211658481469046 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Asp472Asn gyrB_p.Asp472Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1372 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 668 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Asp494Ala gyrB_p.Asp494Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 6 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Asp518Gly gyrB_p.Asp518Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Asp588Asn gyrB_p.Asp588Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1352 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 655 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Asp617Tyr gyrB_p.Asp617Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 3 4000 18532 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 0.999838144051794 0.999527061819887 0.99996662016845 0.4 0.0527449505263169 0.853367200365326 0 0 0.975 0 0 0.707598226178713 0 0 180.190817121615 1 732.5 1798 False False 3.08866666666666 0.257877592435781 26.9864148134858 0 0 0.000921794749483055 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 148.292249815985 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 2 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Asp627Ala gyrB_p.Asp627Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 11.2104345733627 1 732.5 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.22785363871091 1 345 886 False False 0 0 0 0 0 0 0 0 0 9.22785363871091 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Asp640Ala gyrB_p.Asp640Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Asp640Asn gyrB_p.Asp640Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Asp645Ala gyrB_p.Asp645Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1345 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Asp645Glu gyrB_p.Asp645Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1386 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 675 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Asp657Gly gyrB_p.Asp657Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1369 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 664 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Asp97Glu gyrB_p.Asp97Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 4 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Cys388Gly gyrB_p.Cys388Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Gln476Glu gyrB_p.Gln476Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Gln4Arg gyrB_p.Gln4Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Gln503Arg gyrB_p.Gln503Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1388 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 678 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Gln538Arg gyrB_p.Gln538Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1340 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 648 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Gln565His gyrB_p.Gln565His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Gln9His gyrB_p.Gln9His 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Glu151Asp gyrB_p.Glu151Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Glu181Gly gyrB_p.Glu181Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Glu21Asp gyrB_p.Glu21Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Glu21Gln gyrB_p.Glu21Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Glu21Lys gyrB_p.Glu21Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Glu299Gln gyrB_p.Glu299Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Glu364Asp gyrB_p.Glu364Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1353 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Glu379Gly gyrB_p.Glu379Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 2 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Glu397Asp gyrB_p.Glu397Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1347 1798 False False 4.63234191452137 0.0589984289392935 362.546724531758 0 0 0.000921564464586207 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 1741 6639 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999849397590361 0.999161185884076 0.99999618708438 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 652 886 False False 0 0 0 0 0 0 0 3.81332567489948 0.0485516368820753 298.645085154332 0 0 0.00211658481469046 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Glu425Ala gyrB_p.Glu425Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Glu489Gln gyrB_p.Glu489Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Glu501Ala gyrB_p.Glu501Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 4000 18535 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 1 0.999800997443015 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1336 1798 False False Inf 0.869940791113183 Inf 0 0 0.000921794749483055 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 1740 6640 0.00114810562571756 0.000139071172424607 0.00414113746933503 1 0.999444600156968 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 645 886 False False 0 0 0 0 0 0 0 Inf 0.716065670156237 Inf 0 0 0.00211779995375925 1 0.999444600156968 1 2 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Glu501Asp gyrB_p.Glu501Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 43 34 9 61 10 3941 18525 0.0152423788105947 0.011678742647451 0.0195369192137827 0.999460480172646 0.999008028394192 0.999741249920483 0.859154929577464 0.756195284502838 0.930337413944968 0.790697674418604 0.639575247905833 0.89955885332207 0.772727272727272 0.62155705243448 0.885266486061404 17.7577602977247 8.33204692094806 42.0996788567193 2.33586880536756e-18 9 1798 True False 28.6735600101497 14.5545204939216 62.8069920698946 0.00855345911949685 0.00593058457354513 0.0119322691010212 0.999460480172646 0.999008028394192 0.999741249920483 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 17 16 1 33 1 1709 6639 0.0189437428243398 0.0130749855654571 0.0265019595226118 0.999849397590361 0.999161185884076 0.99999618708438 0.970588235294117 0.846732330439682 0.999255635765309 0.941176470588235 0.713110603332779 0.998511825608733 0.941176470588235 0.713110603332779 0.998511825608733 62.1556465769455 9.63549379449829 2570.54708048108 1.38870584652965e-10 8 886 True False 0 0 0 0 0 0 0 128.19602106495 21.4187941753267 5056.24006896455 0.00927536231884058 0.0053106999934664 0.015019011355801 0.999849397590361 0.999161185884076 0.99999618708438 36 Assoc w R 1) Assoc w R Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance) No change yes F 1 +Moxifloxacin gyrB p.Glu501Gly gyrB_p.Glu501Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 180.16529327284 1 732.5 1798 False False 4.63234191452137 0.0589984289392935 362.546724531758 0 0 0.000921564464586207 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 665 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 2 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Glu501Val gyrB_p.Glu501Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 Assoc w RI Marker of R WHO-endorsed gDST assay 2) Assoc w R - Interim Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance) No change yes WHO-end. gDST F 1 +Moxifloxacin gyrB p.Glu586Lys gyrB_p.Glu586Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 11.2098299448075 1 732.5 1798 False False 0 0 7.01683899052165 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 12 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Glu604Gly gyrB_p.Glu604Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1364 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 661 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Glu604Lys gyrB_p.Glu604Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Glu604Val gyrB_p.Glu604Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Glu623Asp gyrB_p.Glu623Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1356 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Glu654Ala gyrB_p.Glu654Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1394 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Glu76Asp gyrB_p.Glu76Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Gly282Asp gyrB_p.Gly282Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 5 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Gly38Ser gyrB_p.Gly38Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Gly436Arg gyrB_p.Gly436Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Gly470Cys gyrB_p.Gly470Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1362 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 660 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 3 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Gly470Ser gyrB_p.Gly470Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1389 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Gly512Arg gyrB_p.Gly512Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 1 6 11 6 3991 18529 0.00274862568715642 0.00137287782368726 0.00491271640366202 0.999676288103587 0.999295549654279 0.999881194471086 0.647058823529411 0.383283663443402 0.857902516889779 0.142857142857142 0.00361029686190058 0.578723197043195 0.142857142857142 0.00361029686190058 0.578723197043195 0.773782677691472 0.016818022976027 6.38061100735286 1 732.5 1798 False False 8.51160945460619 2.88297674381163 28.0631319459274 0.000250501002004008 6.34211615730598e-06 0.00139490333451783 0.999676288103587 0.999295549654279 0.999881194471086 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 5 0 1737 6640 0.00287026406429391 0.000932603401686605 0.00668542657812442 1 0.999444600156968 1 1 0.478176249895018 1 1 0.025 1 1 0.025 1 Inf 0.0979610295051428 Inf 0.20744807830031 31 886 False False 0 0 0 0 0 0 0 Inf 3.49826870712427 Inf 0.000575373993095512 1.4567102175083e-05 0.00320156563526571 1 0.999444600156968 1 49 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Gly520Ala gyrB_p.Gly520Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 1 5 4001 18530 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999730240086323 0.999370583585258 0.99991240407437 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.521823750104981 0 0 0.521823750104981 0 0 5.05597597896217 0.593765431957714 148 1798 False False 0.926268432891777 0.0195789744788398 8.28271147593069 0 0 0.000921564464586207 0.999730240086323 0.999370583585258 0.99991240407437 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 1741 6639 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999849397590361 0.999161185884076 0.99999618708438 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 148.399526333966 1 596 886 False False 0 0 0 0 0 0 0 3.81332567489948 0.0485516368820753 298.645085154332 0 0 0.00211658481469046 0.999849397590361 0.999161185884076 0.99999618708438 52 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Gly520Val gyrB_p.Gly520Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1368 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Gly589Val gyrB_p.Gly589Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Gly594Arg gyrB_p.Gly594Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Gly598Glu gyrB_p.Gly598Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 7.01683899052165 1 732.5 1798 False False 0 0 7.01683899052165 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Gly606Ser gyrB_p.Gly606Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 7.01683899052165 1 732.5 1798 False False 0 0 7.01683899052165 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 4 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.His272Pro gyrB_p.His272Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.His302Arg gyrB_p.His302Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 13 0 13 12 15 3990 18520 0.00299850074962518 0.00155029923838043 0.00523191326268615 0.999190720258969 0.998665566860464 0.999546983769752 0.444444444444444 0.254798806631737 0.646735769677994 0 0 0.24705263800047 0 0 0.218019360910534 0 0 1.52375019524392 0.14335110320447 52 1798 False False 3.71328320802005 1.58558334291387 8.50425971695262 0 0 0.000924103944223174 0.999190720258969 0.998665566860464 0.999546983769752 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 5 6 1737 6634 0.00287026406429391 0.000932603401686605 0.00668542657812442 0.999096385542168 0.998034257105878 0.999668319522948 0.454545454545454 0.167488094063707 0.766206402340654 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.24667152948905 0.35594684257353 63 886 False False 0 0 0 0 0 0 0 3.1826904624832 0.767307891726441 12.5352947163909 0 0 0.00212145375679475 0.999096385542168 0.998034257105878 0.999668319522948 21 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.His311Arg gyrB_p.His311Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1341 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 649 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.His311Tyr gyrB_p.His311Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.His560Arg gyrB_p.His560Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Ile116Met gyrB_p.Ile116Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Ile19Leu gyrB_p.Ile19Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Ile206Ser gyrB_p.Ile206Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1391 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Ile271Met gyrB_p.Ile271Met 1 missense_variant (see "Genomic_coordinates" sheet) 2 135 3 132 10 135 3992 18400 0.00249875062468765 0.00119887813746424 0.004590474851852 0.992716482330725 0.991384847861212 0.993889809051728 0.0689655172413793 0.0335648957602087 0.12317218599507 0.0222222222222222 0.00460641289599499 0.0635684018143328 0.0217391304347826 0.0045057659614902 0.0622154430889073 0.104754964474403 0.0213416040580954 0.313173977271809 2.39465156232638e-08 12 1798 True False 0.341423587916573 0.159939717686535 0.648306256620865 0.000750938673341677 0.000154888388588051 0.00219297790890734 0.992716482330725 0.991384847861212 0.993889809051728 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 35 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Ile271Val gyrB_p.Ile271Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Ile34Val gyrB_p.Ile34Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 0 9 1 9 4001 18526 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999514432155381 0.999078442003892 0.999777944189974 0.1 0.00252857854446178 0.445016117028195 0 0 0.336267116879942 0 0 0.336267116879942 0 0 2.34695624222834 0.376493695096139 114 1798 False False 0.514482490488489 0.0117383297112304 3.71492514851402 0 0 0.000921564464586207 0.999514432155381 0.999078442003892 0.999777944189974 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 3 1741 6637 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999548192771084 0.998680200855815 0.999906816794257 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.23315484406772 1 345 886 False False 0 0 0 0 0 0 0 1.27072563660731 0.0241917279459833 15.8348342618437 0 0 0.00211658481469046 0.999548192771084 0.998680200855815 0.999906816794257 2 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Ile435Val gyrB_p.Ile435Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Ile46Ser gyrB_p.Ile46Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Ile486Leu gyrB_p.Ile486Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 1 3999 18534 0.000749625187406296 0.000154617422592445 0.00218914487959466 0.999946048017264 0.999699435860871 0.999998634054993 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 180.255144665755 1 732.5 1798 False False 13.9039759939985 1.11586102000443 726.694777866907 0 0 0.000922025149498025 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 1740 6640 0.00114810562571756 0.000139071172424607 0.00414113746933503 1 0.999444600156968 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 676 886 False False 0 0 0 0 0 0 0 Inf 0.716065670156237 Inf 0 0 0.00211779995375925 1 0.999444600156968 1 5 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Ile486Val gyrB_p.Ile486Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Ile493Thr gyrB_p.Ile493Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 13 4002 18522 0 0 0.000921334294721226 0.99929862422444 0.998800924705247 0.999626495767062 0 0 0.24705263800047 NA NA NA 0 0 0.24705263800047 NA NA NA NA 1382 1798 False False 0 0 1.51934003385999 0 0 0.000921334294721226 0.99929862422444 0.998800924705247 0.999626495767062 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 7 1742 6633 0 0 0.00211537106925253 0.99894578313253 0.997829124235982 0.999576048424705 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 674 886 False False 0 0 0 0 0 0 0 0 0 2.64457250939033 0 0 0.00211537106925253 0.99894578313253 0.997829124235982 0.999576048424705 49 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Ile505Val gyrB_p.Ile505Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1335 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 644 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 8 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Ile527Val gyrB_p.Ile527Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Ile556Val gyrB_p.Ile556Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 11.2098299448075 1 732.5 1798 False False 0 0 7.01683899052165 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Ile601Thr gyrB_p.Ile601Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Ile607Val gyrB_p.Ile607Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 11.2104345733627 1 732.5 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 27 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Ile84Val gyrB_p.Ile84Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 22 0 22 0 22 4002 18513 0 0 0.000921334294721226 0.998813056379822 0.998203501328592 0.99925600395763 0 0 0.154372512815574 0 0 0.154372512815574 0 0 0.154372512815574 0 0 0.844944309003051 0.0228621426007046 35 1798 False False 0 0 0.844944309003051 0 0 0.000921334294721226 0.998813056379822 0.998203501328592 0.99925600395763 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 0 9 1742 6631 0 0 0.00211537106925253 0.998644578313253 0.997428553721748 0.999380033497835 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.336267116879942 0 0 1.93068643684555 0.218936430493458 46.5 886 False False 0 0 0 0 0 0 0 0 0 1.93068643684555 0 0 0.00211537106925253 0.998644578313253 0.997428553721748 0.999380033497835 24 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Ile93Val gyrB_p.Ile93Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 13 4002 18522 0 0 0.000921334294721226 0.99929862422444 0.998800924705247 0.999626495767062 0 0 0.24705263800047 NA NA NA 0 0 0.24705263800047 NA NA NA NA 1337 1798 False False 0 0 1.51934003385999 0 0 0.000921334294721226 0.99929862422444 0.998800924705247 0.999626495767062 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 7 1742 6633 0 0 0.00211537106925253 0.99894578313253 0.997829124235982 0.999576048424705 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 646 886 False False 0 0 0 0 0 0 0 0 0 2.64457250939033 0 0 0.00211537106925253 0.99894578313253 0.997829124235982 0.999576048424705 50 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Leu156Met gyrB_p.Leu156Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Leu257Pro gyrB_p.Leu257Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 4000 18535 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 1 0.999800997443015 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1363 1798 False False Inf 0.869940791113183 Inf 0 0 0.000921794749483055 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Leu354Val gyrB_p.Leu354Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Leu375Val gyrB_p.Leu375Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1357 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 658 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Leu42Ile gyrB_p.Leu42Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1380 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Leu455Val gyrB_p.Leu455Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Leu509Pro gyrB_p.Leu509Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.118754661339467 Inf 0.177574655011758 72.5 1798 False False Inf 0.118754661339467 Inf 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Leu522Val gyrB_p.Leu522Val 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.118754661339467 Inf 0.177574655011758 72.5 1798 False False Inf 0.118754661339467 Inf 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Leu555Val gyrB_p.Leu555Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Leu563Phe gyrB_p.Leu563Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Leu638Val gyrB_p.Leu638Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Leu673Pro gyrB_p.Leu673Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Leu69Val gyrB_p.Leu69Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Lys159Met gyrB_p.Lys159Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Lys333Arg gyrB_p.Lys333Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Lys339Arg gyrB_p.Lys339Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Lys404Arg gyrB_p.Lys404Arg 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 0 1 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 180.16529327284 1 732.5 1798 False False 4.63234191452137 0.0589984289392935 362.546724531758 0 0 0.000921564464586207 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 0 1 1 1 1741 6639 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999849397590361 0.999161185884076 0.99999618708438 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 148.399526333966 1 596 886 False False 0 0 0 0 0 0 0 3.81332567489948 0.0485516368820753 298.645085154332 0 0 0.00211658481469046 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Lys430Asn gyrB_p.Lys430Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1384 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Lys452Asn gyrB_p.Lys452Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Lys498Asn gyrB_p.Lys498Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Lys521Asn gyrB_p.Lys521Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Lys526Asn gyrB_p.Lys526Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Lys526Gln gyrB_p.Lys526Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 18 0 18 4 19 3998 18516 0.000999500249875062 0.000272395196018755 0.00255712257980299 0.998974912328028 0.998399659444322 0.999382720987534 0.17391304347826 0.0495076453057934 0.387811889954797 0 0 0.185301968137852 0 0 0.176466911806965 0 0 1.05394805686225 0.0580703094965967 43 1798 False False 0.975013822700824 0.241097906402858 2.93607744374046 0 0 0.000922255664717455 0.998974912328028 0.998399659444322 0.999382720987534 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 0 11 1 11 1741 6629 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.998343373493976 0.997037775344334 0.999172737054126 0.0833333333333333 0.00210759323186022 0.384796165150944 0 0 0.284914152918154 0 0 0.284914152918154 0 0 1.51889003485796 0.135207149545168 27 886 False False 0 0 0 0 0 0 0 0.34614380450107 0.0080407298813373 2.38478511505618 0 0 0.00211658481469046 0.998343373493976 0.997037775344334 0.999172737054126 48 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Lys596Asn gyrB_p.Lys596Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 6 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Lys599Arg gyrB_p.Lys599Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1342 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 650 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Lys603Arg gyrB_p.Lys603Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Lys603Asn gyrB_p.Lys603Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Lys668Arg gyrB_p.Lys668Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Lys668Glu gyrB_p.Lys668Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Lys7Gln gyrB_p.Lys7Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Met100Val gyrB_p.Met100Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 3999 18535 0.000749625187406296 0.000154617422592445 0.00218914487959466 1 0.999800997443015 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1348 1798 False False Inf 1.91440039171731 Inf 0 0 0.000922025149498025 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 653 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Met197Ile gyrB_p.Met197Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1358 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 659 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Met291Ile gyrB_p.Met291Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 71 1498 3931 17037 0.0177411294352823 0.0138813015086007 0.0223259954829269 0.919179929862422 0.915162999618393 0.923064767526542 0.0452517527087316 0.0355083222680242 0.0567389762638838 0 0 0.841886116991581 0 0 0.00245950679587733 0 0 23.0829066097021 1 NA NA False True 0.205417110034612 0.159150594177955 0.261430384736685 0 0 0.000937967224503816 0.919179929862422 0.915162999618393 0.923064767526542 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 2 0 2 34 720 1708 5920 0.0195177956371986 0.0135535738415647 0.0271681688076995 0.891566265060241 0.883839643169598 0.89894706672793 0.0450928381962864 0.0314270637845283 0.0624453695525549 0 0 0.841886116991581 0 0 0.00511034123477411 0 0 18.4644279893486 1 NA NA False True 1 1 1 0 0 1 0 0.16367421285454 0.111997964365637 0.23199498450394 0 0 0.00215743487303753 0.891566265060241 0.883839643169598 0.89894706672793 2919 Not assoc w R 5) Not assoc w R No change yes 1 +Moxifloxacin gyrB p.Met530Thr gyrB_p.Met530Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Met58Ile gyrB_p.Met58Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 7.01683899052165 1 732.5 1798 False False 0 0 7.01683899052165 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 1742 6636 0 0 0.00211537106925253 0.999397590361445 0.998458316867766 0.999835840034063 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.77543554850383 0.5866324014095 78.5 886 False False 0 0 0 0 0 0 0 0 0 5.77543554850383 0 0 0.00211537106925253 0.999397590361445 0.998458316867766 0.999835840034063 3 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Met616Val gyrB_p.Met616Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Phe187Leu gyrB_p.Phe187Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 180.110710654533 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Phe475Val gyrB_p.Phe475Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Phe549Leu gyrB_p.Phe549Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Phe672Val gyrB_p.Phe672Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Pro163Leu gyrB_p.Pro163Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Pro163Ser gyrB_p.Pro163Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 5 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Pro177Arg gyrB_p.Pro177Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1354 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 656 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Pro177His gyrB_p.Pro177His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Pro177Leu gyrB_p.Pro177Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 11.2098299448075 1 732.5 1798 False False 0 0 7.01683899052165 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 4 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Pro243Ser gyrB_p.Pro243Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.118754661339467 Inf 0.177574655011758 72.5 1798 False False Inf 0.118754661339467 Inf 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Pro254Leu gyrB_p.Pro254Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 1 6 1 6 4001 18529 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999676288103587 0.999295549654279 0.999881194471086 0.142857142857142 0.00361029686190058 0.578723197043195 0.142857142857142 0.00361029686190058 0.578723197043195 0.142857142857142 0.00361029686190058 0.578723197043195 0.771848704490544 0.0167759984530013 6.36465776860659 1 732.5 1798 False False 0.771848704490544 0.0167759984530013 6.36465776860659 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999676288103587 0.999295549654279 0.999881194471086 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 1 3 1 3 1741 6637 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999548192771084 0.998680200855815 0.999906816794257 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 1.27072563660731 0.0241917279459833 15.8348342618437 1 345 886 False False 0 0 0 0 0 0 0 1.27072563660731 0.0241917279459833 15.8348342618437 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999548192771084 0.998680200855815 0.999906816794257 2 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Pro343Ala gyrB_p.Pro343Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Pro343Leu gyrB_p.Pro343Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Pro343Ser gyrB_p.Pro343Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Pro400Arg gyrB_p.Pro400Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 4002 18530 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 5.05471226039473 0.593754047365944 137.5 1798 False False 0 0 5.05471226039473 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 46 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Pro439Ala gyrB_p.Pro439Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 2 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Pro439Arg gyrB_p.Pro439Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Pro450Arg gyrB_p.Pro450Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 2 4001 18533 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999892096034529 0.999610268708724 0.999986932062044 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1370 1798 False False 2.31604598850287 0.0392471382871788 44.494064095996 0 0 0.000921564464586207 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 666 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Pro480Ser gyrB_p.Pro480Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1346 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Pro578Ala gyrB_p.Pro578Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 4002 18530 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 5.05471226039473 0.593754047365944 137.5 1798 False False 0 0 5.05471226039473 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.22785363871091 1 345 886 False False 0 0 0 0 0 0 0 0 0 9.22785363871091 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Pro578Arg gyrB_p.Pro578Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Pro578Ser gyrB_p.Pro578Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.118754661339467 Inf 0.177574655011758 72.5 1798 False False Inf 0.118754661339467 Inf 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0977360898734989 Inf 0.207826294440467 35.5 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Pro628Ala gyrB_p.Pro628Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 1 5 4001 18530 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999730240086323 0.999370583585258 0.99991240407437 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.521823750104981 0 0 0.521823750104981 0 0 5.05597597896217 0.593765431957714 148 1798 False False 0.926268432891777 0.0195789744788398 8.28271147593069 0 0 0.000921564464586207 0.999730240086323 0.999370583585258 0.99991240407437 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Pro94Leu gyrB_p.Pro94Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 8 426 3994 18109 0.00199900049975012 0.000863409206250761 0.003935008292197 0.977016455354734 0.97475584653127 0.979125645603973 0.0184331797235023 0.00799089788430192 0.0359964312218906 NA NA NA 0 0 0.00862195732956672 NA NA NA NA NA NA False True 0.08514649909136 0.0364690698574988 0.16951469040713 0 0 0.00092317887936968 0.977016455354734 0.97475584653127 0.979125645603973 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 3 206 1739 6434 0.00172215843857634 0.000355291378803123 0.00502455256196275 0.968975903614457 0.964518865533279 0.973014495257153 0.0143540669856459 0.00296999248786838 0.0413733649354524 NA NA NA 0 0 0.0177478010074704 NA NA NA NA NA NA False True 1 1 1 0 0 1 0 0.0538809828212844 0.011026943480657 0.160008598187714 0 0 0.00211901648886052 0.968975903614457 0.964518865533279 0.973014495257153 309 Not assoc w R 5) Not assoc w R No change yes 1 +Moxifloxacin gyrB p.Ser16Cys gyrB_p.Ser16Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1365 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 662 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Ser248Gly gyrB_p.Ser248Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Ser273Gly gyrB_p.Ser273Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Ser274Arg gyrB_p.Ser274Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 1 5 4001 18530 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999730240086323 0.999370583585258 0.99991240407437 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.602364635616474 0 0 0.521823750104981 0 0 7.01821447943561 1 732.5 1798 False False 0.926268432891777 0.0195789744788398 8.28271147593069 0 0 0.000921564464586207 0.999730240086323 0.999370583585258 0.99991240407437 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.22785363871091 1 345 886 False False 0 0 0 0 0 0 0 0 0 9.22785363871091 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 22 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Ser274Gly gyrB_p.Ser274Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 11.2104345733627 1 732.5 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 12 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Ser274Thr gyrB_p.Ser274Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Ser279Phe gyrB_p.Ser279Phe 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1383 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Ser359Thr gyrB_p.Ser359Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Ser363Arg gyrB_p.Ser363Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Ser413Ala gyrB_p.Ser413Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Ser447Ala gyrB_p.Ser447Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 4000 18535 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 1 0.999800997443015 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1349 1798 False False Inf 0.869940791113183 Inf 0 0 0.000921794749483055 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 1740 6640 0.00114810562571756 0.000139071172424607 0.00414113746933503 1 0.999444600156968 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 654 886 False False 0 0 0 0 0 0 0 Inf 0.716065670156237 Inf 0 0 0.00211779995375925 1 0.999444600156968 1 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Ser447Phe gyrB_p.Ser447Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 22 3 19 7 20 3995 18515 0.00174912543728135 0.000703519237747539 0.00360052552178143 0.998920960345292 0.998334000286012 0.999340773887116 0.259259259259259 0.111144562845442 0.462848742276171 0.136363636363636 0.0290558511287467 0.349122097257408 0.130434782608695 0.0277515074227932 0.335889137537121 0.731769975627429 0.138642679669092 2.48771982170438 0.784398578408254 188 1798 False False 1.6220901126408 0.579099075999289 3.99645593520083 0.000750375187593796 0.00015477214409776 0.00219133353969646 0.998920960345292 0.998334000286012 0.999340773887116 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 14 1 13 2 13 1740 6627 0.00114810562571756 0.000139071172424607 0.00414113746933503 0.998042168674698 0.996654375813144 0.998957138349653 0.133333333333333 0.0165759134400836 0.404602696603372 0.0714285714285714 0.00180678065912538 0.338684489931821 0.0714285714285714 0.00180678065912538 0.338684489931821 0.292970822281167 0.0068934197556991 1.95322268884446 0.325911587863821 54 886 False False 0 0 0 0 0 0 0 0.585941644562334 0.0641396918001474 2.59212039495554 0.000574382538770821 1.45420010902056e-05 0.00319605610685329 0.998042168674698 0.996654375813144 0.998957138349653 29 FQ cross-resistance 2) Assoc w R - Interim Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance) UP from Uncertain to AwRI yes FQ X-R F 4 +Moxifloxacin gyrB p.Ser447Tyr gyrB_p.Ser447Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 7.01683899052165 1 732.5 1798 False False 0 0 7.01683899052165 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 9 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Ser576Gly gyrB_p.Ser576Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 11.2104345733627 1 732.5 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Ser576Ile gyrB_p.Ser576Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 4002 18529 0 0 0.000921334294721226 0.999676288103587 0.999295549654279 0.999881194471086 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.93385874811763 0.599069212767884 166.5 1798 False False 0 0 3.93385874811763 0 0 0.000921334294721226 0.999676288103587 0.999295549654279 0.999881194471086 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 1742 6634 0 0 0.00211537106925253 0.999096385542168 0.998034257105878 0.999668319522948 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.23733664541029 0.355668965817841 60.5 886 False False 0 0 0 0 0 0 0 0 0 3.23733664541029 0 0 0.00211537106925253 0.999096385542168 0.998034257105878 0.999668319522948 5 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Ser576Thr gyrB_p.Ser576Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Ser661Thr gyrB_p.Ser661Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 10 137 3992 18398 0.00249875062468765 0.00119887813746424 0.004590474851852 0.992608578365255 0.991268021361785 0.993790894108989 0.0680272108843537 0.0331014220368499 0.121545322049692 0 0 0.707598226178713 0 0 0.0265668510962833 0 0 11.1572874253046 1 732.5 1798 False False 0.336402732472243 0.157639409600598 0.638465819162015 0 0 0.000923641180173822 0.992608578365255 0.991268021361785 0.993790894108989 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 47 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Thr167Ala gyrB_p.Thr167Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Thr167Met gyrB_p.Thr167Met 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1350 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Thr170Ala gyrB_p.Thr170Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1355 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 657 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Thr170Lys gyrB_p.Thr170Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Thr182Ile gyrB_p.Thr182Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1333 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Thr183Met gyrB_p.Thr183Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Thr189Pro gyrB_p.Thr189Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Thr209Ala gyrB_p.Thr209Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Thr214Pro gyrB_p.Thr214Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Thr250Ser gyrB_p.Thr250Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Thr267Ser gyrB_p.Thr267Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 11.2104345733627 1 732.5 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Thr373Ala gyrB_p.Thr373Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1376 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 671 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Thr378Ser gyrB_p.Thr378Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 1 5 4001 18530 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999730240086323 0.999370583585258 0.99991240407437 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.521823750104981 0 0 0.521823750104981 0 0 5.05597597896217 0.593765431957714 148 1798 False False 0.926268432891777 0.0195789744788398 8.28271147593069 0 0 0.000921564464586207 0.999730240086323 0.999370583585258 0.99991240407437 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 1742 6635 0 0 0.00211537106925253 0.999246987951807 0.99824360331506 0.999755455269461 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.16029237021718 0.590665917903267 90.5 886 False False 0 0 0 0 0 0 0 0 0 4.16029237021718 0 0 0.00211537106925253 0.999246987951807 0.99824360331506 0.999755455269461 2 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Thr37Ser gyrB_p.Thr37Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Thr393Ser gyrB_p.Thr393Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 10 4002 18525 0 0 0.000921334294721226 0.999460480172646 0.999008028394192 0.999741249920483 0 0 0.30849710781876 NA NA NA 0 0 0.30849710781876 NA NA NA NA 1338 1798 False False 0 0 2.06609723386524 0 0 0.000921334294721226 0.999460480172646 0.999008028394192 0.999741249920483 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 1742 6634 0 0 0.00211537106925253 0.999096385542168 0.998034257105878 0.999668319522948 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 647 886 False False 0 0 0 0 0 0 0 0 0 3.23733664541029 0 0 0.00211537106925253 0.999096385542168 0.998034257105878 0.999668319522948 5 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Thr500Ala gyrB_p.Thr500Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 2 2 11 5 3991 18530 0.00274862568715642 0.00137287782368726 0.00491271640366202 0.999730240086323 0.999370583585258 0.99991240407437 0.6875 0.413379363548641 0.889830045282882 0.5 0.067585986488543 0.932414013511457 0.285714285714285 0.0366925661760855 0.709579136262657 4.64294662991731 0.336417927437046 64.124123909942 0.146929859730822 55 1798 False False 10.214482585818 3.26907909994366 37.5080041584285 0.000500876533934385 6.06642288798471e-05 0.00180815492083237 0.999730240086323 0.999370583585258 0.99991240407437 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 7 3 1735 6637 0.00401836969001148 0.00161707270669399 0.00826174702450177 0.999548192771084 0.998680200855815 0.999906816794257 0.7 0.347547149940002 0.933260488822265 0 0 0.975 0 0 0.707598226178713 0 0 148.866780924761 1 98.5 886 False False 0 0 0 0 0 0 0 8.92584053794428 2.03437944423322 53.5713864598474 0 0 0.00212389663781701 0.999548192771084 0.998680200855815 0.999906816794257 14 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Thr500Asn gyrB_p.Thr500Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 16 8 8 18 9 3984 18526 0.00449775112443778 0.00266776479404919 0.00709910547036896 0.999514432155381 0.999078442003892 0.999777944189974 0.666666666666666 0.460392713907742 0.834811820312684 0.5 0.246510111490575 0.753489888509424 0.470588235294117 0.22983268726599 0.721881699668893 4.65010040160642 1.52016427750433 14.2234509784877 0.00320745775386743 25 1798 False False 9.30020080321285 3.96347761127435 23.5081441173034 0.00200400801603206 0.000865573016756711 0.00394485593711735 0.999514432155381 0.999078442003892 0.999777944189974 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 3 2 11 2 1731 6638 0.00631458094144661 0.00315630578799124 0.0112703796091745 0.999698795180722 0.998912372612698 0.9999635206173 0.846153846153846 0.545528944323442 0.980793328017471 0.6 0.146632799634673 0.947255049473683 0.6 0.146632799634673 0.947255049473683 5.75216637781629 0.658205268988994 69.0074150415481 0.0634368323653625 22 886 False False 0 0 0 0 0 0 0 21.0912767186597 4.59496637326057 195.445643528853 0.00173010380622837 0.000356931208254131 0.00504769533021062 0.999698795180722 0.998912372612698 0.9999635206173 16 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Thr500Ile gyrB_p.Thr500Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 180.16529327284 1 732.5 1798 False False 4.63234191452137 0.0589984289392935 362.546724531758 0 0 0.000921564464586207 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 1741 6639 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999849397590361 0.999161185884076 0.99999618708438 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 148.399526333966 1 596 886 False False 0 0 0 0 0 0 0 3.81332567489948 0.0485516368820753 298.645085154332 0 0 0.00211658481469046 0.999849397590361 0.999161185884076 0.99999618708438 4 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Thr500Pro gyrB_p.Thr500Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 4000 18534 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 0.999946048017264 0.999699435860871 0.999998634054993 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 180.210207769499 1 732.5 1798 False False 9.267 0.482236652039982 544.73752523911 0 0 0.000921794749483055 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Thr664Ile gyrB_p.Thr664Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 7.01683899052165 1 732.5 1798 False False 0 0 7.01683899052165 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Tyr144Phe gyrB_p.Tyr144Phe 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1373 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Tyr144Ser gyrB_p.Tyr144Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Tyr253Ser gyrB_p.Tyr253Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Tyr582His gyrB_p.Tyr582His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1343 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 651 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 4 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Val127Ala gyrB_p.Val127Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Val222Met gyrB_p.Val222Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Val226Ala gyrB_p.Val226Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Val301Leu gyrB_p.Val301Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 17 227 3985 18308 0.00424787606196901 0.00247643232973908 0.00679257671634936 0.987752899919072 0.986063671479731 0.989286401756597 0.0696721311475409 0.0411076132384687 0.109209859427167 NA NA NA 0 0 0.0161192421133921 NA NA NA NA NA NA False True 0.344061154439279 0.196698815881192 0.564071767414595 0 0 0.00092526288561947 0.987752899919072 0.986063671479731 0.989286401756597 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 8 94 1734 6546 0.00459242250287026 0.00198470392380438 0.00902874874953196 0.985843373493976 0.982703377068919 0.988545260641522 0.0784313725490196 0.0344693411051634 0.148701888888272 NA NA NA 0 0 0.0384833509975287 NA NA NA NA NA NA False True 0 1 1 0 0 1 0 0.321283957888537 0.13451844739433 0.661197320089173 0 0 0.00212512018929921 0.985843373493976 0.982703377068919 0.988545260641522 323 Not assoc w R 5) Not assoc w R No change yes 1 +Moxifloxacin gyrB p.Val327Leu gyrB_p.Val327Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Val407Leu gyrB_p.Val407Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Val427Met gyrB_p.Val427Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 3 2 3 2 3999 18533 0.000749625187406296 0.000154617422592445 0.00218914487959466 0.999892096034529 0.999610268708724 0.999986932062044 0.6 0.146632799634673 0.947255049473683 0.6 0.146632799634673 0.947255049473683 0.6 0.146632799634673 0.947255049473683 6.9516129032258 0.795983567419885 83.4550561301111 0.0421205450919633 41 1798 False False 6.9516129032258 0.795983567419885 83.4550561301111 0.000749625187406296 0.000154617422592445 0.00218914487959466 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 2 2 2 2 1740 6638 0.00114810562571756 0.000139071172424607 0.00414113746933503 0.999698795180722 0.998912372612698 0.9999635206173 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 3.81494252873563 0.27628448752053 52.6296495890773 0.192900950226214 30 886 False False 0 0 0 0 0 0 0 3.81494252873563 0.27628448752053 52.6296495890773 0.00114810562571756 0.000139071172424607 0.00414113746933503 0.999698795180722 0.998912372612698 0.9999635206173 3 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Val457Leu gyrB_p.Val457Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 1 7 12 11 3990 18524 0.00299850074962518 0.00155029923838043 0.00523191326268615 0.99940652818991 0.998938363693644 0.999703704968061 0.521739130434782 0.305878001491373 0.731803813824446 0.125 0.0031597235312519 0.526509670875206 0.0833333333333333 0.00210759323186022 0.384796165150944 0.663229502327246 0.0147156276536351 5.16463575806127 1 732.5 1798 False False 5.06466165413533 2.04400841759896 12.6759296063568 0.000250563768479077 6.34370525679008e-06 0.00139525264658973 0.99940652818991 0.998938363693644 0.999703704968061 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 3 2 1739 6638 0.00172215843857634 0.000355291378803123 0.00502455256196275 0.999698795180722 0.998912372612698 0.9999635206173 0.6 0.146632799634673 0.947255049473683 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3400355540914 1 345 886 False False 0 0 0 0 0 0 0 5.72570442783208 0.655180308104634 68.6863687806226 0 0 0.00211901648886052 0.999698795180722 0.998912372612698 0.9999635206173 62 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Val535Ile gyrB_p.Val535Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Val561Gly gyrB_p.Val561Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1344 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Val630Ile gyrB_p.Val630Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 4002 18530 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 5.05471226039473 0.593754047365944 137.5 1798 False False 0 0 5.05471226039473 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 15 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Val670Ile gyrB_p.Val670Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Val670Phe gyrB_p.Val670Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 7 6 3995 18529 0.00174912543728135 0.000703519237747539 0.00360052552178143 0.999676288103587 0.999295549654279 0.999881194471086 0.538461538461538 0.251345482270303 0.807767558198712 0 0 0.521823750104981 0 0 0.4592581264399 0 0 5.06329834140149 0.593831696447146 154.5 1798 False False 5.41105548602419 1.55602663123592 19.4973834281957 0 0 0.000922947902467247 0.999676288103587 0.999295549654279 0.999881194471086 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 3 2 1739 6638 0.00172215843857634 0.000355291378803123 0.00502455256196275 0.999698795180722 0.998912372612698 0.9999635206173 0.6 0.146632799634673 0.947255049473683 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3400355540914 1 345 886 False False 0 0 0 0 0 0 0 5.72570442783208 0.655180308104634 68.6863687806226 0 0 0.00211901648886052 0.999698795180722 0.998912372612698 0.9999635206173 1 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Val675Ile gyrB_p.Val675Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1359 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin gyrB p.Val68Ala gyrB_p.Val68Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin gyrB p.Val75Gly gyrB_p.Val75Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Moxifloxacin Rv1129c c.1026C>T Rv1129c_c.1026C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.1050C>T Rv1129c_c.1050C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 11.2104345733627 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.22785363871091 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.1068C>T Rv1129c_c.1068C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.106C>T Rv1129c_c.106C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.1093C>T Rv1129c_c.1093C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.-10T>C Rv1129c_c.-10T>C 2 upstream_gene_variant 1254544 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c c.1125A>C Rv1129c_c.1125A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 13 4000 18522 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 0.99929862422444 0.998800924705247 0.999626495767062 0.133333333333333 0.0165759134400836 0.404602696603372 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.712384615384615 0.0780187907102555 3.14836469457445 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 20 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.1140C>T Rv1129c_c.1140C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.1167G>A Rv1129c_c.1167G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.-11A>C Rv1129c_c.-11A>C 2 upstream_gene_variant 1254545 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c c.1212G>T Rv1129c_c.1212G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.1215T>C Rv1129c_c.1215T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.1216C>T Rv1129c_c.1216C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.1221C>T Rv1129c_c.1221C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.1224G>A Rv1129c_c.1224G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.1242C>T Rv1129c_c.1242C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.1263G>A Rv1129c_c.1263G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.1269C>A Rv1129c_c.1269C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.1299C>G Rv1129c_c.1299C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 11.2104345733627 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.-12A>C Rv1129c_c.-12A>C 2 upstream_gene_variant 1254546 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c c.-12A>T Rv1129c_c.-12A>T 2 upstream_gene_variant 1254546 0 0 0 0 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1685 1798 False False 4.63234191452137 0.0589984289392935 362.546724531758 0 0 0.000921564464586207 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c c.1317G>C Rv1129c_c.1317G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.1317G>T Rv1129c_c.1317G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 4002 18529 0 0 0.000921334294721226 0.999676288103587 0.999295549654279 0.999881194471086 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.93385874811763 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 20.3050873563561 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.132A>G Rv1129c_c.132A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.135C>T Rv1129c_c.135C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.1362G>A Rv1129c_c.1362G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.1389C>T Rv1129c_c.1389C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.-13A>G Rv1129c_c.-13A>G 2 upstream_gene_variant 1254547 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c c.1404G>A Rv1129c_c.1404G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.-15G>A Rv1129c_c.-15G>A 2 upstream_gene_variant 1254549 1 11 0 11 1 19 4001 18516 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.998974912328028 0.998399659444322 0.999382720987534 0.05 0.0012650894979498 0.248732762772027 0 0 0.284914152918154 0 0 0.176466911806965 0 0 1.84479092292821 0.231460719790749 97 1798 False False 0.243570686275799 0.00586409590918313 1.53309294453711 0 0 0.000921564464586207 0.998974912328028 0.998399659444322 0.999382720987534 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 4 1742 6636 0 0 0.00211537106925253 0.999397590361445 0.998458316867766 0.999835840034063 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 148.247680227162 1 345 886 False False 0 0 0 0 0 0 0 0 0 5.77543554850383 0 0 0.00211537106925253 0.999397590361445 0.998458316867766 0.999835840034063 40 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c c.15T>C Rv1129c_c.15T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.-17T>G Rv1129c_c.-17T>G 2 upstream_gene_variant 1254551 1 4 0 4 0 7 4002 18528 0 0 0.000921334294721226 0.999622336120852 0.999222023868969 0.999848146482689 0 0 0.409616397225003 0 0 0.602364635616474 0 0 0.409616397225003 0 0 7.0157031190513 1 732.5 1798 False False 0 0 3.21342445526953 0 0 0.000921334294721226 0.999622336120852 0.999222023868969 0.999848146482689 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 148.292249815985 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 3 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c c.186G>A Rv1129c_c.186G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.18C>T Rv1129c_c.18C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.-18T>G Rv1129c_c.-18T>G 2 upstream_gene_variant 1254552 1 0 0 0 3 1 3999 18534 0.000749625187406296 0.000154617422592445 0.00218914487959466 0.999946048017264 0.999699435860871 0.999998634054993 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 1665 1798 False False 13.9039759939985 1.11586102000443 726.694777866907 0 0 0.000922025149498025 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c c.-19T>C Rv1129c_c.-19T>C 2 upstream_gene_variant 1254553 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c c.-1C>T Rv1129c_c.-1C>T 2 upstream_gene_variant 1254535 1 3 0 3 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 11.2098299448075 1 732.5 1798 False False 0 0 7.01683899052165 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 1742 6636 0 0 0.00211537106925253 0.999397590361445 0.998458316867766 0.999835840034063 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.22646396172322 1 345 886 False False 0 0 0 0 0 0 0 0 0 5.77543554850383 0 0 0.00211537106925253 0.999397590361445 0.998458316867766 0.999835840034063 7 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c c.211C>T Rv1129c_c.211C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.-21C>G Rv1129c_c.-21C>G 2 upstream_gene_variant 1254555 1 4 0 4 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 7.01683899052165 1 732.5 1798 False False 0 0 7.01683899052165 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c c.-21C>T Rv1129c_c.-21C>T 2 upstream_gene_variant 1254555 1 1 0 1 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 180.16529327284 1 732.5 1798 False False 4.63234191452137 0.0589984289392935 362.546724531758 0 0 0.000921564464586207 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c c.-22A>G Rv1129c_c.-22A>G 2 upstream_gene_variant 1254556 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1661 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c c.-23C>A Rv1129c_c.-23C>A 2 upstream_gene_variant 1254557 1 12 0 12 0 12 4002 18523 0 0 0.000921334294721226 0.999352576207175 0.998869354319296 0.999665423355947 0 0 0.264648469397051 0 0 0.264648469397051 0 0 0.264648469397051 0 0 1.66656583988199 0.142106949470919 50.5 1798 False False 0 0 1.66656583988199 0 0 0.000921334294721226 0.999352576207175 0.998869354319296 0.999665423355947 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.22785363871091 1 345 886 False False 0 0 0 0 0 0 0 0 0 9.22785363871091 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 31 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c c.-23C>T Rv1129c_c.-23C>T 2 upstream_gene_variant 1254557 1 0 0 0 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1662 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 823 886 False False 0 0 0 0 0 0 0 0 0 9.22785363871091 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 4 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c c.246A>G Rv1129c_c.246A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.24G>T Rv1129c_c.24G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.-25G>A Rv1129c_c.-25G>A 2 upstream_gene_variant 1254559 NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1654 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c c.264G>C Rv1129c_c.264G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.-26C>T Rv1129c_c.-26C>T 2 upstream_gene_variant 1254560 1 0 0 0 1 4 4001 18531 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999784192069058 0.999447539013843 0.999941196572055 0.2 0.00505076337946806 0.716417936118089 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1686 1798 False False 1.15789802549362 0.0235059760051305 11.7081385811536 0 0 0.000921564464586207 0.999784192069058 0.999447539013843 0.999941196572055 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 1741 6639 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999849397590361 0.999161185884076 0.99999618708438 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 837 886 False False 0 0 0 0 0 0 0 3.81332567489948 0.0485516368820753 298.645085154332 0 0 0.00211658481469046 0.999849397590361 0.999161185884076 0.99999618708438 9 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c c.-27C>T Rv1129c_c.-27C>T 2 upstream_gene_variant 1254561 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1697 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c c.282C>T Rv1129c_c.282C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.-28T>C Rv1129c_c.-28T>C 2 upstream_gene_variant 1254562 NA 0 0 0 2973 9628 1029 8907 0.74287856071964 0.729038810019411 0.756362852258688 0.4805503102239 0.473334142740429 0.487772581685899 0.235933656059042 0.228542419809506 0.243447043687126 NA NA NA 0 0 0.000383067393464645 NA NA NA NA 1640 1798 False True 2.67285195875489 2.47464571934099 2.88843543540608 0 0 0.00357849872235683 0.4805503102239 0.473334142740429 0.487772581685899 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 1399 3897 343 2743 0.803099885189437 0.783635154202158 0.821537908439012 0.413102409638554 0.40122411504734 0.425057080252473 0.264161631419939 0.252325689727551 0.276257985816214 NA NA NA 0 0 0.000946146797037489 NA NA NA NA 811 886 False True 0 1 1 0 0 0 0 2.87090615416957 2.52316469388873 3.27193055211173 0 0 0.010697125032766 0.413102409638554 0.40122411504734 0.425057080252473 14944 5) Not assoc w R New NotAwR yes 5 +Moxifloxacin Rv1129c c.294G>A Rv1129c_c.294G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.-29A>G Rv1129c_c.-29A>G 2 upstream_gene_variant 1254563 1 2 0 2 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 24.6614555089698 1 732.5 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 65 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c c.-2A>G Rv1129c_c.-2A>G 2 upstream_gene_variant 1254536 1 3 0 3 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 11.2104345733627 1 732.5 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.22785363871091 1 345 886 False False 0 0 0 0 0 0 0 0 0 9.22785363871091 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 3 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c c.303C>T Rv1129c_c.303C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.309C>T Rv1129c_c.309C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.-31T>C Rv1129c_c.-31T>C 2 upstream_gene_variant 1254565 1 4 0 4 0 5 4002 18530 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 7.01646036669751 1 198.5 1798 False False 0 0 5.05471226039473 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 840 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 4 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c c.-31T>G Rv1129c_c.-31T>G 2 upstream_gene_variant 1254565 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c c.334C>A Rv1129c_c.334C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.336G>C Rv1129c_c.336G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.345G>A Rv1129c_c.345G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.-36T>C Rv1129c_c.-36T>C 2 upstream_gene_variant 1254570 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c c.375C>T Rv1129c_c.375C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.-37G>A Rv1129c_c.-37G>A 2 upstream_gene_variant 1254571 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1690 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c c.-38T>C Rv1129c_c.-38T>C 2 upstream_gene_variant 1254572 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1711 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c c.39T>C Rv1129c_c.39T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 4.63234191452137 0.0589984289392935 362.546724531758 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.3G>A Rv1129c_c.3G>A 2 initiator_codon_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 2 4000 18533 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 0.999892096034529 0.999610268708724 0.999986932062044 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 4.63325 0.335715582549978 63.989229087488 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 14 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.-40T>G Rv1129c_c.-40T>G 2 upstream_gene_variant 1254574 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c c.-41T>C Rv1129c_c.-41T>C 2 upstream_gene_variant 1254575 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c c.-42C>A Rv1129c_c.-42C>A 2 upstream_gene_variant 1254576 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c c.-42C>T Rv1129c_c.-42C>T 2 upstream_gene_variant 1254576 1 4 0 4 0 6 4002 18529 0 0 0.000921334294721226 0.999676288103587 0.999295549654279 0.999881194471086 0 0 0.4592581264399 0 0 0.602364635616474 0 0 0.4592581264399 0 0 7.01608174287405 1 732.5 1798 False False 0 0 3.93385874811763 0 0 0.000921334294721226 0.999676288103587 0.999295549654279 0.999881194471086 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.22785363871091 1 345 886 False False 0 0 0 0 0 0 0 0 0 9.22785363871091 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 5 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c c.-42delC Rv1129c_c.-42delC 2 upstream_gene_variant 1254575 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c c.435C>T Rv1129c_c.435C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 11.2104345733627 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.22785363871091 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.-43A>G Rv1129c_c.-43A>G 2 upstream_gene_variant 1254577 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c c.-43A>T Rv1129c_c.-43A>T 2 upstream_gene_variant 1254577 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c c.-44T>C Rv1129c_c.-44T>C 2 upstream_gene_variant 1254578 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1694 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c c.-46C>G Rv1129c_c.-46C>G 2 upstream_gene_variant 1254580 1 20 0 20 12 26 3990 18509 0.00299850074962518 0.00155029923838043 0.00523191326268615 0.99859724844888 0.997945314710086 0.999083477869708 0.31578947368421 0.175025338901126 0.486527054406021 0 0 0.168433470983085 0 0 0.132274604497754 0 0 0.940095466680663 0.0363079890303244 40 1798 False False 2.14100636205899 0.983246865422338 4.39962808449165 0 0 0.000924103944223174 0.99859724844888 0.997945314710086 0.999083477869708 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 3 10 1739 6630 0.00172215843857634 0.000355291378803123 0.00502455256196275 0.998493975903614 0.99723211779991 0.999277574112589 0.23076923076923 0.0503810734911515 0.53813153923404 0 0 0.30849710781876 0 0 0.30849710781876 0 0 1.70282382368962 0.23193955561991 50 886 False False 0 0 0 0 0 0 0 1.14376078205865 0.202050230784826 4.44840654151636 0 0 0.00211901648886052 0.998493975903614 0.99723211779991 0.999277574112589 59 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c c.-46C>T Rv1129c_c.-46C>T 2 upstream_gene_variant 1254580 1 2 0 2 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 24.6614555089698 1 732.5 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 8 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c c.474C>T Rv1129c_c.474C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.477C>T Rv1129c_c.477C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.-47G>A Rv1129c_c.-47G>A 2 upstream_gene_variant 1254581 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c c.480C>T Rv1129c_c.480C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 11 4002 18524 0 0 0.000921334294721226 0.99940652818991 0.998938363693644 0.999703704968061 0 0 0.284914152918154 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.84512569595635 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 20.3050873563561 NA NA NA NA NA NA 18 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.-48A>C Rv1129c_c.-48A>C 2 upstream_gene_variant 1254582 NA 0 0 0 9 144 3993 18391 0.00224887556221889 0.00102882864885218 0.00426475484372027 0.992230914486107 0.990859640048119 0.993444175039583 0.0588235294117647 0.0272477067942125 0.10872670464178 NA NA NA 0 0 0.0252918814875166 NA NA NA NA 1677 1798 False True 0.287863135487102 0.128891691194316 0.562540149930926 0 0 0.000923409971909585 0.992230914486107 0.990859640048119 0.993444175039583 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 8 99 1734 6541 0.00459242250287026 0.00198470392380438 0.00902874874953196 0.985090361445783 0.981877552258535 0.987866102642522 0.0747663551401869 0.0328306621056333 0.142011614421373 NA NA NA 0 0 0.0365757449834789 NA NA NA NA 831 886 False True 0 1 1 0 0 0 0 0.30482448475528 0.127823666481238 0.626066714974621 0 0 0.00212512018929921 0.985090361445783 0.981877552258535 0.987866102642522 285 5) Not assoc w R New NotAwR yes 5 +Moxifloxacin Rv1129c c.-48A>G Rv1129c_c.-48A>G 2 upstream_gene_variant 1254582 1 47 0 47 7 79 3995 18456 0.00174912543728135 0.000703519237747539 0.00360052552178143 0.995737793363906 0.994690808909588 0.9966241620863729 0.0813953488372093 0.0333524290301759 0.160539671333081 0 0 0.0754857336910586 0 0 0.045621252758611 0 0 0.377399906356567 0.00016613777799788 22 1798 True False 0.409347126946658 0.159281835798829 0.884450582333834 0 0 0.000922947902467247 0.995737793363906 0.994690808909588 0.9966241620863729 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 22 0 22 0 31 1742 6609 0 0 0.00211537106925253 0.995331325301204 0.993379679989432 0.996825723749185 0 0 0.11218874692237 0 0 0.154372512815574 0 0 0.11218874692237 0 0 0.693510390257236 0.0080599957598935 16 886 False False 0 0 0 0 0 0 0 0 0 0.480076482851295 0 0 0.00211537106925253 0.995331325301204 0.993379679989432 0.996825723749185 290 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c c.-48dupA Rv1129c_c.-48dupA 2 upstream_gene_variant 1254581 1 7 0 7 0 11 4002 18524 0 0 0.000921334294721226 0.99940652818991 0.998938363693644 0.999703704968061 0 0 0.284914152918154 0 0 0.409616397225003 0 0 0.284914152918154 0 0 3.21272966723324 0.615329967469725 183 1798 False False 0 0 1.84512569595635 0 0 0.000921334294721226 0.99940652818991 0.998938363693644 0.999703704968061 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.302036906212 1 345 886 False False 0 0 0 0 0 0 0 0 0 9.22785363871091 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 11 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c c.-49A>C Rv1129c_c.-49A>C 2 upstream_gene_variant 1254583 1 63 0 63 6 78 3996 18457 0.00149925037481259 0.000550390926465245 0.00326035944931569 0.995791745346641 0.994750650740022 0.996672170547471 0.0714285714285714 0.0266630040318368 0.149012308640404 0 0 0.0568723523320162 0 0 0.0461924203280487 0 0 0.278692644750212 7.4707388315048e-06 19 1798 True False 0.355297605297605 0.126441299539376 0.809614780349714 0 0 0.00092271704111551 0.995791745346641 0.994750650740022 0.996672170547471 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 30 0 30 2 37 1740 6603 0.00114810562571756 0.000139071172424607 0.00414113746933503 0.994427710843373 0.992327435354648 0.996073649274423 0.0512820512820512 0.00627197209569041 0.173244781373605 0 0 0.115703308222027 0 0 0.0948905874149899 0 0 0.497229202185437 0.0012599622922906 13 886 False False 0 0 0 0 0 0 0 0.205125815470643 0.0239158492067962 0.796654090909091 0 0 0.00211779995375925 0.994427710843373 0.992327435354648 0.996073649274423 255 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c c.-49A>G Rv1129c_c.-49A>G 2 upstream_gene_variant 1254583 1 3 0 3 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 11.2104345733627 1 732.5 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 5 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c c.-4G>A Rv1129c_c.-4G>A 2 upstream_gene_variant 1254538 1 1 0 1 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 180.110710654533 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c c.-4G>T Rv1129c_c.-4G>T 2 upstream_gene_variant 1254538 1 1 0 1 1 2 4001 18533 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999892096034529 0.999610268708724 0.999986932062044 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 180.155600359953 1 732.5 1798 False False 2.31604598850287 0.0392471382871788 44.494064095996 0 0 0.000921564464586207 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 846 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 3 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c c.570G>A Rv1129c_c.570G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.576C>A Rv1129c_c.576C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.57T>C Rv1129c_c.57T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.591G>C Rv1129c_c.591G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 11.2104345733627 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.22785363871091 NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.627T>C Rv1129c_c.627T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.648C>G Rv1129c_c.648C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.651G>A Rv1129c_c.651G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.678C>T Rv1129c_c.678C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 11.2104345733627 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.682C>A Rv1129c_c.682C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.6G>A Rv1129c_c.6G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.-6G>A Rv1129c_c.-6G>A 2 upstream_gene_variant 1254540 1 5 0 5 0 6 4002 18529 0 0 0.000921334294721226 0.999676288103587 0.999295549654279 0.999881194471086 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 5.0544394993781 0.593751589252307 129 1798 False False 0 0 3.93385874811763 0 0 0.000921334294721226 0.999676288103587 0.999295549654279 0.999881194471086 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.22785363871091 1 345 886 False False 0 0 0 0 0 0 0 0 0 9.22785363871091 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 20 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c c.70C>A Rv1129c_c.70C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 4 4001 18531 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999784192069058 0.999447539013843 0.999941196572055 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.15789802549362 0.0235059760051305 11.7081385811536 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 1741 6639 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999849397590361 0.999161185884076 0.99999618708438 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.81332567489948 0.0485516368820753 298.645085154332 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.736C>T Rv1129c_c.736C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 4001 18533 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999892096034529 0.999610268708724 0.999986932062044 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.31604598850287 0.0392471382871788 44.494064095996 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.742C>T Rv1129c_c.742C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.753G>A Rv1129c_c.753G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.756A>C Rv1129c_c.756A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.816C>T Rv1129c_c.816C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.852C>T Rv1129c_c.852C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.864C>A Rv1129c_c.864C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.-8T>C Rv1129c_c.-8T>C 2 upstream_gene_variant 1254542 NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1669 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c c.-8T>G Rv1129c_c.-8T>G 2 upstream_gene_variant 1254542 1 2 0 2 2 3 4000 18532 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 0.999838144051794 0.999527061819887 0.99996662016845 0.4 0.0527449505263169 0.853367200365326 0 0 0.841886116991581 0 0 0.707598226178713 0 0 24.6737809278898 1 732.5 1798 False False 3.08866666666666 0.257877592435781 26.9864148134858 0 0 0.000921794749483055 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 2 1740 6638 0.00114810562571756 0.000139071172424607 0.00414113746933503 0.999698795180722 0.998912372612698 0.9999635206173 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 148.462305278969 1 345 886 False False 0 0 0 0 0 0 0 3.81494252873563 0.27628448752053 52.6296495890773 0 0 0.00211779995375925 0.999698795180722 0.998912372612698 0.9999635206173 7 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c c.903T>C Rv1129c_c.903T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.915G>T Rv1129c_c.915G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01683899052165 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 20.3050873563561 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.927G>A Rv1129c_c.927G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.936G>A Rv1129c_c.936G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.969A>G Rv1129c_c.969A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 7 56 3995 18479 0.00174912543728135 0.000703519237747539 0.00360052552178143 0.996978688966819 0.996078346752294 0.997716951542235 0.111111111111111 0.0458566237168707 0.215624248702528 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.578191489361702 0.222169622027649 1.27284617177454 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 6 27 1736 6613 0.00344431687715269 0.00126502019745104 0.00748164597286304 0.995933734939759 0.994089272018054 0.997318647254181 0.181818181818181 0.06978788366631 0.354600559450268 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.846518177163338 0.285339262722721 2.09747035007759 NA NA NA NA NA NA 56 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.978C>T Rv1129c_c.978C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.987G>A Rv1129c_c.987G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 20.3050873563561 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.996A>C Rv1129c_c.996A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.9G>T Rv1129c_c.9G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 4002 18529 0 0 0.000921334294721226 0.999676288103587 0.999295549654279 0.999881194471086 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.93385874811763 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.22785363871091 NA NA NA NA NA NA 15 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv1129c c.-9T>G Rv1129c_c.-9T>G 2 upstream_gene_variant 1254543 1 47 3 44 3 240 3999 18295 0.000749625187406296 0.000154617422592445 0.00218914487959466 0.987051524143512 0.985318358268281 0.988629278696994 0.0123456790123456 0.00255324808059716 0.0356533749059068 0.0638297872340425 0.0133617694972549 0.17539243001292 0.0123456790123456 0.00255324808059716 0.0356533749059068 0.311924572052103 0.0619336565948527 0.973855317733859 0.0359395157839577 39 1798 False False 0.0571861715428857 0.0117138700570303 0.169277115336888 0.000749625187406296 0.000154617422592445 0.00218914487959466 0.987051524143512 0.985318358268281 0.988629278696994 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 1 6 1 16 1741 6624 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.997590361445783 0.996089839735676 0.9986220756008 0.0588235294117647 0.00148817439126663 0.28688939666722 0.142857142857142 0.00361029686190058 0.578723197043195 0.0588235294117647 0.00148817439126663 0.28688939666722 0.634118322802986 0.0137816969025201 5.23258377799 1 345 886 False False 0 0 0 0 0 0 0 0.23779437105112 0.00567088448598808 1.53285211689986 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.997590361445783 0.996089839735676 0.9986220756008 611 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c LoF Rv1129c_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 6 0 6 2 9 4000 18526 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 0.999514432155381 0.999078442003892 0.999777944189974 0.181818181818181 0.0228311982999596 0.517755852360172 0 0 0.4592581264399 0 0 0.336267116879942 0 0 3.93518914546313 0.599060339226452 159 1798 False False 1.02922222222222 0.108163524664371 4.97516458757911 0 0 0.000921794749483055 0.999514432155381 0.999078442003892 0.999777944189974 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 886 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Ala104Thr Rv1129c_p.Ala104Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.118748254282209 Inf 0.177582534611288 85 1798 False False 4.63234191452137 0.0589984289392935 362.546724531758 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 815 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Ala111Gly Rv1129c_p.Ala111Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1655 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Ala129Pro Rv1129c_p.Ala129Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Ala130Pro Rv1129c_p.Ala130Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Ala141Thr Rv1129c_p.Ala141Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1691 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Ala150Thr Rv1129c_p.Ala150Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Ala150Val Rv1129c_p.Ala150Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Ala195Pro Rv1129c_p.Ala195Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 6 4000 18529 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 0.999676288103587 0.999295549654279 0.999881194471086 0.25 0.0318540262499442 0.650855794412824 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1678 1798 False False 1.54408333333333 0.15233241265383 8.63930225227516 0 0 0.000921794749483055 0.999676288103587 0.999295549654279 0.999881194471086 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 5 1741 6635 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999246987951807 0.99824360331506 0.999755455269461 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA 0 0 0.521823750104981 NA NA NA NA 832 886 False False 0 0 0 0 0 0 0 0.76220562894888 0.016109698917676 6.81778471156948 0 0 0.00211658481469046 0.999246987951807 0.99824360331506 0.999755455269461 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Ala216Pro Rv1129c_p.Ala216Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1663 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Ala230Thr Rv1129c_p.Ala230Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 1 5 4001 18530 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999730240086323 0.999370583585258 0.99991240407437 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.602364635616474 0 0 0.521823750104981 0 0 7.01821447943561 1 732.5 1798 False False 0.926268432891777 0.0195789744788398 8.28271147593069 0 0 0.000921564464586207 0.999730240086323 0.999370583585258 0.99991240407437 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 4 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Ala239Thr Rv1129c_p.Ala239Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1668 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 824 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Ala239Val Rv1129c_p.Ala239Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 180.110710654533 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Ala342Ser Rv1129c_p.Ala342Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1672 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 827 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Ala351Val Rv1129c_p.Ala351Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 3 4001 18532 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999838144051794 0.999527061819887 0.99996662016845 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 24.6676166728131 1 732.5 1798 False False 1.5439473464967 0.0294026895471131 19.2327580431529 0 0 0.000921564464586207 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 1741 6638 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999698795180722 0.998912372612698 0.9999635206173 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 148.377228822259 1 345 886 False False 0 0 0 0 0 0 0 1.90637564618035 0.032294587677361 36.6438813236649 0 0 0.00211658481469046 0.999698795180722 0.998912372612698 0.9999635206173 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Ala353Gly Rv1129c_p.Ala353Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1643 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Ala373Thr Rv1129c_p.Ala373Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 4 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Ala383Glu Rv1129c_p.Ala383Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 4001 18533 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999892096034529 0.999610268708724 0.999986932062044 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6689469404428 1 732.5 1798 False False 2.31604598850287 0.0392471382871788 44.494064095996 0 0 0.000921564464586207 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 829 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 6 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Ala383Thr Rv1129c_p.Ala383Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Ala400Thr Rv1129c_p.Ala400Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 11 4002 18524 0 0 0.000921334294721226 0.99940652818991 0.998938363693644 0.999703704968061 0 0 0.284914152918154 NA NA NA 0 0 0.284914152918154 NA NA NA NA 1681 1798 False False 0 0 1.84512569595635 0 0 0.000921334294721226 0.99940652818991 0.998938363693644 0.999703704968061 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 27 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Ala445Thr Rv1129c_p.Ala445Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Ala456Val Rv1129c_p.Ala456Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Ala468Thr Rv1129c_p.Ala468Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 180.110710654533 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Ala73Thr Rv1129c_p.Ala73Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 11.2098299448075 1 732.5 1798 False False 0 0 7.01683899052165 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 148.292249815985 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Arg112Trp Rv1129c_p.Arg112Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Arg126Trp Rv1129c_p.Arg126Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 6 4002 18529 0 0 0.000921334294721226 0.999676288103587 0.999295549654279 0.999881194471086 0 0 0.4592581264399 0 0 0.602364635616474 0 0 0.4592581264399 0 0 7.01608174287405 1 732.5 1798 False False 0 0 3.93385874811763 0 0 0.000921334294721226 0.999676288103587 0.999295549654279 0.999881194471086 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.302036906212 1 345 886 False False 0 0 0 0 0 0 0 0 0 9.22785363871091 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 5 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Arg151Gln Rv1129c_p.Arg151Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Arg165His Rv1129c_p.Arg165His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Arg201Gln Rv1129c_p.Arg201Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Arg228Trp Rv1129c_p.Arg228Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Arg294Cys Rv1129c_p.Arg294Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 180.110710654533 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 5 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Arg294Ser Rv1129c_p.Arg294Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Arg300Ser Rv1129c_p.Arg300Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Arg308His Rv1129c_p.Arg308His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1707 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Arg309Gln Rv1129c_p.Arg309Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Arg309Trp Rv1129c_p.Arg309Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 180.110710654533 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Arg358Trp Rv1129c_p.Arg358Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 1 2 4001 18533 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999892096034529 0.999610268708724 0.999986932062044 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 2.31604598850287 0.0392471382871788 44.494064095996 0.443741098632247 119.5 1798 False False 2.31604598850287 0.0392471382871788 44.494064095996 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 4 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Arg3fs Rv1129c_p.Arg3fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 180.16529327284 1 732.5 1798 False False 4.63234191452137 0.0589984289392935 362.546724531758 0 0 0.000921564464586207 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Arg3Gln Rv1129c_p.Arg3Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 24.660125576486 1 198.5 1798 False False 0 0 7.01683899052165 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 148.269965029351 1 345 886 False False 0 0 0 0 0 0 0 0 0 9.22785363871091 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 3 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Arg3Pro Rv1129c_p.Arg3Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Asn166Asp Rv1129c_p.Asn166Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 9 14 3993 18521 0.00224887556221889 0.00102882864885218 0.00426475484372027 0.999244672241704 0.998733012789936 0.999586995715357 0.391304347826087 0.197076423969014 0.61458104261115 0 0 0.369416647552819 0 0 0.231635761650116 0 0 2.71850783747982 0.365180196472168 112 1798 False False 2.98180744874959 1.13755825093344 7.40237556542993 0 0 0.000923409971909585 0.999244672241704 0.998733012789936 0.999586995715357 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 6 5 1736 6635 0.00344431687715269 0.00126502019745104 0.00748164597286304 0.999246987951807 0.99824360331506 0.999755455269461 0.545454545454545 0.233793597659345 0.832511905936292 0 0 0.707598226178713 0 0 0.521823750104981 0 0 9.2569634947397 1 98.5 886 False False 0 0 0 0 0 0 0 4.58640552995391 1.1643911437424 19.0057314673459 0 0 0.00212267449445866 0.999246987951807 0.99824360331506 0.999755455269461 23 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Asn211Asp Rv1129c_p.Asn211Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1698 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 843 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 7 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Asn211Ser Rv1129c_p.Asn211Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Asn411Asp Rv1129c_p.Asn411Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Asn411Tyr Rv1129c_p.Asn411Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 3 14 3999 18521 0.000749625187406296 0.000154617422592445 0.00218914487959466 0.999244672241704 0.998733012789936 0.999586995715357 0.176470588235294 0.0379850680706259 0.434317872844283 NA NA NA 0 0 0.231635761650116 NA NA NA NA 1648 1798 False False 0.992444539706355 0.182781663597741 3.55815859863829 0 0 0.000922025149498025 0.999244672241704 0.998733012789936 0.999586995715357 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 11 1742 6629 0 0 0.00211537106925253 0.998343373493976 0.997037775344334 0.999172737054126 0 0 0.284914152918154 NA NA NA 0 0 0.284914152918154 NA NA NA NA 816 886 False False 0 0 0 0 0 0 0 0 0 1.51801526894139 0 0 0.00211537106925253 0.998343373493976 0.997037775344334 0.999172737054126 35 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Asn451Lys Rv1129c_p.Asn451Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Asn5fs Rv1129c_p.Asn5fs 2 frameshift (see "Genomic_coordinates" sheet) 1 3 0 3 0 5 4002 18530 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 11.2092253162358 1 732.5 1798 False False 0 0 5.05471226039473 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Asn5Ser Rv1129c_p.Asn5Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 5 4002 18530 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 11.2092253162358 1 732.5 1798 False False 0 0 5.05471226039473 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 148.269965029351 1 345 886 False False 0 0 0 0 0 0 0 0 0 9.22785363871091 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Asp160Ala Rv1129c_p.Asp160Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 27 1 26 18 47 3984 18488 0.00449775112443778 0.00266776479404919 0.00709910547036896 0.997464256811437 0.996629409512271 0.998136254486262 0.276923076923076 0.173100359402193 0.401901181349343 0.037037037037037 0.000937257091944708 0.189705617413044 0.0208333333333333 0.00052731525342312 0.110696160593152 0.178483163422922 0.00435602321040162 1.08713871646908 0.0727514801471094 44 1798 False False 1.77723660599846 0.97033142861862 3.12184821664947 0.000250941028858218 6.35325660199231e-06 0.00139735219849169 0.997464256811437 0.996629409512271 0.998136254486262 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 7 13 1735 6627 0.00401836969001148 0.00161707270669399 0.00826174702450177 0.998042168674698 0.996654375813144 0.998957138349653 0.35 0.153909204784541 0.592188534532828 0 0 0.336267116879942 0 0 0.24705263800047 0 0 1.93731345465668 0.218931095903173 44 886 False False 0 0 0 0 0 0 0 2.05670583019286 0.693607846739954 5.55595896157386 0 0 0.00212389663781701 0.998042168674698 0.996654375813144 0.998957138349653 73 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Asp160Asn Rv1129c_p.Asp160Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 2 4 4000 18531 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 0.999784192069058 0.999447539013843 0.999941196572055 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.841886116991581 0 0 0.602364635616474 0 0 24.6724503259111 1 732.5 1798 False False 2.316375 0.209452463855679 16.1672355802828 0 0 0.000921794749483055 0.999784192069058 0.999447539013843 0.999941196572055 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 2 1740 6638 0.00114810562571756 0.000139071172424607 0.00414113746933503 0.999698795180722 0.998912372612698 0.9999635206173 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 148.462305278969 1 345 886 False False 0 0 0 0 0 0 0 3.81494252873563 0.27628448752053 52.6296495890773 0 0 0.00211779995375925 0.999698795180722 0.998912372612698 0.9999635206173 6 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Asp160Glu Rv1129c_p.Asp160Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 180.101020147088 1 732.5 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 148.292249815985 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Asp160Gly Rv1129c_p.Asp160Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 1 8 4001 18527 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999568384138117 0.999149722782159 0.999813641077243 0.111111111111111 0.00280913674659921 0.482496514917337 0 0 0.4592581264399 0 0 0.369416647552819 0 0 3.93441760632448 0.599065478106383 161.5 1798 False False 0.578824043989002 0.0130447733848513 4.31945136015563 0 0 0.000921564464586207 0.999568384138117 0.999149722782159 0.999813641077243 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 1 5 1741 6635 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999246987951807 0.99824360331506 0.999755455269461 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.16268347134163 0.590656717325847 87 886 False False 0 0 0 0 0 0 0 0.76220562894888 0.016109698917676 6.81778471156948 0 0 0.00211658481469046 0.999246987951807 0.99824360331506 0.999755455269461 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Asp164His Rv1129c_p.Asp164His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1664 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Asp191Gly Rv1129c_p.Asp191Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 10 0 10 0 10 4002 18525 0 0 0.000921334294721226 0.999460480172646 0.999008028394192 0.999741249920483 0 0 0.30849710781876 0 0 0.30849710781876 0 0 0.30849710781876 0 0 2.06609723386524 0.22623165660618 91 1798 False False 0 0 2.06609723386524 0 0 0.000921334294721226 0.999460480172646 0.999008028394192 0.999741249920483 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 0 10 1742 6630 0 0 0.00211537106925253 0.998493975903614 0.99723211779991 0.999277574112589 0 0 0.30849710781876 0 0 0.30849710781876 0 0 0.30849710781876 0 0 1.69989001249307 0.232118932117224 51.5 886 False False 0 0 0 0 0 0 0 0 0 1.69989001249307 0 0 0.00211537106925253 0.998493975903614 0.99723211779991 0.999277574112589 16 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Asp200Ala Rv1129c_p.Asp200Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Asp200Asn Rv1129c_p.Asp200Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1699 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Asp209Ala Rv1129c_p.Asp209Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Asp209Gly Rv1129c_p.Asp209Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1695 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Asp214Asn Rv1129c_p.Asp214Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1644 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Asp223His Rv1129c_p.Asp223His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Asp262Gly Rv1129c_p.Asp262Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 2 4000 18533 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 0.999892096034529 0.999610268708724 0.999986932062044 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1646 1798 False False 4.63325 0.335715582549978 63.989229087488 0 0 0.000921794749483055 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 1741 6639 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999849397590361 0.999161185884076 0.99999618708438 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 814 886 False False 0 0 0 0 0 0 0 3.81332567489948 0.0485516368820753 298.645085154332 0 0 0.00211658481469046 0.999849397590361 0.999161185884076 0.99999618708438 3 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Asp387Gly Rv1129c_p.Asp387Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 11.2104345733627 1 732.5 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Asp419Asn Rv1129c_p.Asp419Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1702 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Asp41Asn Rv1129c_p.Asp41Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1673 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 828 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Gln105Glu Rv1129c_p.Gln105Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1659 1798 False False 4.63234191452137 0.0589984289392935 362.546724531758 0 0 0.000921564464586207 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Gln105Pro Rv1129c_p.Gln105Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 4001 18533 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999892096034529 0.999610268708724 0.999986932062044 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 180.155600359953 1 732.5 1798 False False 2.31604598850287 0.0392471382871788 44.494064095996 0 0 0.000921564464586207 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 1741 6639 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999849397590361 0.999161185884076 0.99999618708438 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 845 886 False False 0 0 0 0 0 0 0 3.81332567489948 0.0485516368820753 298.645085154332 0 0 0.00211658481469046 0.999849397590361 0.999161185884076 0.99999618708438 4 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Gln237Pro Rv1129c_p.Gln237Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Gln329Pro Rv1129c_p.Gln329Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 2 3 4000 18532 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 0.999838144051794 0.999527061819887 0.99996662016845 0.4 0.0527449505263169 0.853367200365326 0 0 0.841886116991581 0 0 0.707598226178713 0 0 24.6737809278898 1 732.5 1798 False False 3.08866666666666 0.257877592435781 26.9864148134858 0 0 0.000921794749483055 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 1740 6640 0.00114810562571756 0.000139071172424607 0.00414113746933503 1 0.999444600156968 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 853 886 False False 0 0 0 0 0 0 0 Inf 0.716065670156237 Inf 0 0 0.00211779995375925 1 0.999444600156968 1 7 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Gln384His Rv1129c_p.Gln384His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1670 1798 False False 4.63234191452137 0.0589984289392935 362.546724531758 0 0 0.000921564464586207 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 1741 6639 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999849397590361 0.999161185884076 0.99999618708438 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 826 886 False False 0 0 0 0 0 0 0 3.81332567489948 0.0485516368820753 298.645085154332 0 0 0.00211658481469046 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Gln74His Rv1129c_p.Gln74His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1705 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Glu107Asp Rv1129c_p.Glu107Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 4001 18533 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999892096034529 0.999610268708724 0.999986932062044 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 180.155600359953 1 732.5 1798 False False 2.31604598850287 0.0392471382871788 44.494064095996 0 0 0.000921564464586207 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 1741 6639 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999849397590361 0.999161185884076 0.99999618708438 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 148.399526333966 1 596 886 False False 0 0 0 0 0 0 0 3.81332567489948 0.0485516368820753 298.645085154332 0 0 0.00211658481469046 0.999849397590361 0.999161185884076 0.99999618708438 11 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Glu133Asp Rv1129c_p.Glu133Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 10 6 3992 18529 0.00249875062468765 0.00119887813746424 0.004590474851852 0.999676288103587 0.999295549654279 0.999881194471086 0.625 0.354346094302078 0.848016324918877 0 0 0.521823750104981 0 0 0.4592581264399 0 0 5.06710450186723 0.593866344699382 156 1798 False False 7.73588844355377 2.5452518809124 25.9100824219052 0 0 0.000923641180173822 0.999676288103587 0.999295549654279 0.999881194471086 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.22785363871091 1 345 886 False False 0 0 0 0 0 0 0 0 0 9.22785363871091 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 9 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Glu133Lys Rv1129c_p.Glu133Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 5 4001 18530 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999730240086323 0.999370583585258 0.99991240407437 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.707598226178713 0 0 0.521823750104981 0 0 11.2120263107716 1 732.5 1798 False False 0.926268432891777 0.0195789744788398 8.28271147593069 0 0 0.000921564464586207 0.999730240086323 0.999370583585258 0.99991240407437 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 856 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 6 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Glu135Ala Rv1129c_p.Glu135Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 9 18 3993 18517 0.00224887556221889 0.00102882864885218 0.00426475484372027 0.999028864310763 0.998465619515959 0.999424345094191 0.333333333333333 0.165188179687315 0.539607286092257 0 0 0.369416647552819 0 0 0.185301968137852 0 0 2.71792085567015 0.365178612556082 111 1798 False False 2.31868269471575 0.91686874552673 5.43976358395184 0 0 0.000923409971909585 0.999028864310763 0.998465619515959 0.999424345094191 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 5 1741 6635 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999246987951807 0.99824360331506 0.999755455269461 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.841886116991581 0 0 0.521823750104981 0 0 20.30756665591 1 345 886 False False 0 0 0 0 0 0 0 0.76220562894888 0.016109698917676 6.81778471156948 0 0 0.00211658481469046 0.999246987951807 0.99824360331506 0.999755455269461 30 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Glu135Gln Rv1129c_p.Glu135Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 24.6614555089698 1 732.5 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Glu135Gly Rv1129c_p.Glu135Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 4 7 3998 18528 0.000999500249875062 0.000272395196018755 0.00255712257980299 0.999622336120852 0.999222023868969 0.999848146482689 0.363636363636363 0.109263443819098 0.692095284988322 0 0 0.602364635616474 0 0 0.409616397225003 0 0 7.02272407843033 1 732.5 1798 False False 2.64818123347388 0.56818026021858 10.4221554541931 0 0 0.000922255664717455 0.999622336120852 0.999222023868969 0.999848146482689 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 854 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 9 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Glu135Lys Rv1129c_p.Glu135Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 1 6 6 7 3996 18528 0.00149925037481259 0.000550390926465245 0.00326035944931569 0.999622336120852 0.999222023868969 0.999848146482689 0.461538461538461 0.192232441801288 0.748654517729696 0.142857142857142 0.00361029686190058 0.578723197043195 0.125 0.0031597235312519 0.526509670875206 0.772772772772772 0.0167960778981587 6.37228049935053 1 198.5 1798 False False 3.97425997425997 1.10268314247504 13.8181860257783 0.000250187640730547 6.33418258703928e-06 0.00139315939446562 0.999622336120852 0.999222023868969 0.999848146482689 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 4 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Glu146Lys Rv1129c_p.Glu146Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Glu146Val Rv1129c_p.Glu146Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Glu156Gly Rv1129c_p.Glu156Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1712 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 850 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Glu157Gly Rv1129c_p.Glu157Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1723 1798 False False 4.63234191452137 0.0589984289392935 362.546724531758 0 0 0.000921564464586207 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Glu297Gln Rv1129c_p.Glu297Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1713 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 851 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Glu440Ala Rv1129c_p.Glu440Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1656 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 820 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 7 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Glu471Asp Rv1129c_p.Glu471Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Glu98Ala Rv1129c_p.Glu98Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1724 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Glu98Gly Rv1129c_p.Glu98Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 3 2 3999 18533 0.000749625187406296 0.000154617422592445 0.00218914487959466 0.999892096034529 0.999610268708724 0.999986932062044 0.6 0.146632799634673 0.947255049473683 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6812792139651 1 732.5 1798 False False 6.9516129032258 0.795983567419885 83.4550561301111 0 0 0.000922025149498025 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Glu98Lys Rv1129c_p.Glu98Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 11 0 11 0 11 4002 18524 0 0 0.000921334294721226 0.99940652818991 0.998938363693644 0.999703704968061 0 0 0.284914152918154 0 0 0.284914152918154 0 0 0.284914152918154 0 0 1.84512569595635 0.231452145338353 94.5 1798 False False 0 0 1.84512569595635 0 0 0.000921334294721226 0.99940652818991 0.998938363693644 0.999703704968061 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 0 10 1742 6630 0 0 0.00211537106925253 0.998493975903614 0.99723211779991 0.999277574112589 0 0 0.30849710781876 0 0 0.30849710781876 0 0 0.30849710781876 0 0 1.69989001249307 0.232118932117224 51.5 886 False False 0 0 0 0 0 0 0 0 0 1.69989001249307 0 0 0.00211537106925253 0.998493975903614 0.99723211779991 0.999277574112589 9 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Gly103Ala Rv1129c_p.Gly103Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1703 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Gly117Ala Rv1129c_p.Gly117Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1687 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Gly184Ala Rv1129c_p.Gly184Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Gly188Arg Rv1129c_p.Gly188Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1683 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Gly189Glu Rv1129c_p.Gly189Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Gly250Arg Rv1129c_p.Gly250Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Gly271Ser Rv1129c_p.Gly271Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 11.2104345733627 1 732.5 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Gly311Glu Rv1129c_p.Gly311Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 1 5 4001 18530 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999730240086323 0.999370583585258 0.99991240407437 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.521823750104981 0 0 0.521823750104981 0 0 5.05597597896217 0.593765431957714 148 1798 False False 0.926268432891777 0.0195789744788398 8.28271147593069 0 0 0.000921564464586207 0.999730240086323 0.999370583585258 0.99991240407437 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 6 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Gly360Asp Rv1129c_p.Gly360Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 180.110710654533 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 821 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 4 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Gly360Val Rv1129c_p.Gly360Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 180.101020147088 1 732.5 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Gly361Ala Rv1129c_p.Gly361Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1641 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Gly361Asp Rv1129c_p.Gly361Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 180.101020147088 1 732.5 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Gly361Cys Rv1129c_p.Gly361Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 3 4001 18532 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999838144051794 0.999527061819887 0.99996662016845 0.25 0.00630946320970987 0.805879550316756 0 0 0.975 0 0 0.707598226178713 0 0 180.145907444122 1 732.5 1798 False False 1.5439473464967 0.0294026895471131 19.2327580431529 0 0 0.000921564464586207 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 847 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Gly361Ser Rv1129c_p.Gly361Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 4001 18533 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999892096034529 0.999610268708724 0.999986932062044 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 180.155600359953 1 732.5 1798 False False 2.31604598850287 0.0392471382871788 44.494064095996 0 0 0.000921564464586207 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 825 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Gly361Val Rv1129c_p.Gly361Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Gly402Arg Rv1129c_p.Gly402Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1717 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Gly402Glu Rv1129c_p.Gly402Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 10 0 10 1 12 4001 18523 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999352576207175 0.998869354319296 0.999665423355947 0.0769230769230769 0.00194562849734675 0.360297435267877 0 0 0.30849710781876 0 0 0.264648469397051 0 0 2.06639081216068 0.226237159264387 93 1798 False False 0.385799383487461 0.00902616489023748 2.60901007892481 0 0 0.000921564464586207 0.999352576207175 0.998869354319296 0.999665423355947 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 1 5 1741 6635 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999246987951807 0.99824360331506 0.999755455269461 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.16268347134163 0.590656717325847 87 886 False False 0 0 0 0 0 0 0 0.76220562894888 0.016109698917676 6.81778471156948 0 0 0.00211658481469046 0.999246987951807 0.99824360331506 0.999755455269461 28 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Gly404Ala Rv1129c_p.Gly404Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1647 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Gly415Val Rv1129c_p.Gly415Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1650 1798 False False 4.63234191452137 0.0589984289392935 362.546724531758 0 0 0.000921564464586207 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 818 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Gly431Arg Rv1129c_p.Gly431Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1688 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 838 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Gly446Cys Rv1129c_p.Gly446Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1660 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Gly446Ser Rv1129c_p.Gly446Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1708 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Gly446Val Rv1129c_p.Gly446Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Gly474Asp Rv1129c_p.Gly474Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 180.110710654533 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 822 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.His118Pro Rv1129c_p.His118Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1692 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.His231Pro Rv1129c_p.His231Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1674 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.His293Asn Rv1129c_p.His293Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1651 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.His355Arg Rv1129c_p.His355Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Ile106Val Rv1129c_p.Ile106Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1684 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 835 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Ile303Leu Rv1129c_p.Ile303Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1700 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Ile303Thr Rv1129c_p.Ile303Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1666 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Ile378Met Rv1129c_p.Ile378Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1671 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Ile443Met Rv1129c_p.Ile443Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Ile443Thr Rv1129c_p.Ile443Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 2 7 4000 18528 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 0.999622336120852 0.999222023868969 0.999848146482689 0.222222222222222 0.0281449734778982 0.600093573716312 0.333333333333333 0.00840375865961264 0.905700675949754 0.125 0.0031597235312519 0.526509670875206 2.316 0.0392463565493927 44.4931836272225 0.443746997283523 121 1798 False False 1.32342857142857 0.134121374884385 6.95403216044878 0.000249937515621094 6.32785000763801e-06 0.00139176737893813 0.999622336120852 0.999222023868969 0.999848146482689 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Ile443Val Rv1129c_p.Ile443Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Ile95Thr Rv1129c_p.Ile95Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1718 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Ile95Val Rv1129c_p.Ile95Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Leu134Pro Rv1129c_p.Leu134Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 6 4002 18529 0 0 0.000921334294721226 0.999676288103587 0.999295549654279 0.999881194471086 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 5.0544394993781 0.593751589252307 129 1798 False False 0 0 3.93385874811763 0 0 0.000921334294721226 0.999676288103587 0.999295549654279 0.999881194471086 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Leu190Ser Rv1129c_p.Leu190Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 11.2104345733627 1 732.5 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Leu212Arg Rv1129c_p.Leu212Arg 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 5 3 3997 18532 0.00124937531234382 0.000405789275012681 0.0029131967931525 0.999838144051794 0.999527061819887 0.99996662016845 0.625 0.244863216366551 0.914766585862746 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1682 1798 False False 7.72746226336419 1.50254187991877 49.8116162659229 0 0 0.00092248629522778 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 1 1740 6639 0.00114810562571756 0.000139071172424607 0.00414113746933503 0.999849397590361 0.999161185884076 0.99999618708438 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 834 886 False False 0 0 0 0 0 0 0 7.63103448275862 0.396930405600961 448.930838944076 0 0 0.00211779995375925 0.999849397590361 0.999161185884076 0.99999618708438 13 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Leu212Pro Rv1129c_p.Leu212Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1652 1798 False False 4.63234191452137 0.0589984289392935 362.546724531758 0 0 0.000921564464586207 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 819 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 6 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Leu227Phe Rv1129c_p.Leu227Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Leu299Ser Rv1129c_p.Leu299Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1714 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Leu305Pro Rv1129c_p.Leu305Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Leu321Phe Rv1129c_p.Leu321Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1675 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Leu420Arg Rv1129c_p.Leu420Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Leu426Ile Rv1129c_p.Leu426Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1719 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Lys341Asn Rv1129c_p.Lys341Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1721 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Lys425Arg Rv1129c_p.Lys425Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Lys425Thr Rv1129c_p.Lys425Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Lys448Thr Rv1129c_p.Lys448Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1642 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 812 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Met1? Rv1129c_p.Met1? 2 start_lost (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1676 1798 False False 4.63234191452137 0.0589984289392935 362.546724531758 0 0 0.000921564464586207 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 830 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Met113Ile Rv1129c_p.Met113Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 4002 18530 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 7.01646036669751 1 198.5 1798 False False 0 0 5.05471226039473 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 1742 6636 0 0 0.00211537106925253 0.999397590361445 0.998458316867766 0.999835840034063 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.22646396172322 1 345 886 False False 0 0 0 0 0 0 0 0 0 5.77543554850383 0 0 0.00211537106925253 0.999397590361445 0.998458316867766 0.999835840034063 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Met113Thr Rv1129c_p.Met113Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 180.110710654533 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Met153Ile Rv1129c_p.Met153Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 11.2104345733627 1 732.5 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Met174Val Rv1129c_p.Met174Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1725 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Met179Ile Rv1129c_p.Met179Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 11.2104345733627 1 732.5 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Phe109Leu Rv1129c_p.Phe109Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Phe202Tyr Rv1129c_p.Phe202Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 24 2 22 64 41 3938 18494 0.015992003998001 0.0123370028574755 0.0203760962400777 0.99778796870785 0.99700031369348 0.998412154855195 0.609523809523809 0.509444304991104 0.703258703627557 0.0833333333333333 0.0102563412812501 0.269972801557603 0.0465116279069767 0.00568325697874796 0.158111458308697 0.426935684934669 0.0486508612803386 1.73796468233615 0.294333979482341 98 1798 False False 7.33079810229285 4.86839528842243 11.1460151672746 0.000507614213197969 6.14803490342535e-05 0.0018324616901948 0.99778796870785 0.99700031369348 0.998412154855195 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 14 1 13 33 17 1709 6623 0.0189437428243398 0.0130749855654571 0.0265019595226118 0.997439759036144 0.995903960705664 0.998507879902128 0.66 0.512347512278411 0.787945286564618 0.0714285714285714 0.00180678065912538 0.338684489931821 0.0555555555555555 0.00140555616736942 0.272943599673368 0.298105054687851 0.00701407798129542 1.98746939377296 0.326134354176835 55 886 False False 0 0 0 0 0 0 0 7.52276873300519 4.05942829392564 14.4349538557128 0.000584795321637426 1.4805626058964e-05 0.00325391887037917 0.997439759036144 0.995903960705664 0.998507879902128 5 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Phe334Leu Rv1129c_p.Phe334Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 5 7 3997 18528 0.00124937531234382 0.000405789275012681 0.0029131967931525 0.999622336120852 0.999222023868969 0.999848146482689 0.416666666666666 0.15165222980843 0.723330314317894 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1679 1798 False False 3.31105471961113 0.828126003666664 12.1283175870888 0 0 0.00092248629522778 0.999622336120852 0.999222023868969 0.999848146482689 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 3 6 1739 6634 0.00172215843857634 0.000355291378803123 0.00502455256196275 0.999096385542168 0.998034257105878 0.999668319522948 0.333333333333333 0.0748546314196918 0.700704943791459 NA NA NA 0 0 0.4592581264399 NA NA NA NA 833 886 False False 0 0 0 0 0 0 0 1.90741805635422 0.308342874955066 8.94179813553793 0 0 0.00211901648886052 0.999096385542168 0.998034257105878 0.999668319522948 18 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Phe356Val Rv1129c_p.Phe356Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Phe460Leu Rv1129c_p.Phe460Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 180.110710654533 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Pro149Leu Rv1129c_p.Pro149Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1706 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Pro149Ser Rv1129c_p.Pro149Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Pro437Leu Rv1129c_p.Pro437Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1653 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Pro461Leu Rv1129c_p.Pro461Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1667 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Pro461Thr Rv1129c_p.Pro461Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1696 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 842 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Pro8fs Rv1129c_p.Pro8fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Ser119Arg Rv1129c_p.Ser119Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1645 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 813 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Ser266Asn Rv1129c_p.Ser266Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1689 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Ser357Arg Rv1129c_p.Ser357Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 180.110710654533 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Ser357Asn Rv1129c_p.Ser357Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1701 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 844 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Ser454Ala Rv1129c_p.Ser454Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Ser475Arg Rv1129c_p.Ser475Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 24.6614555089698 1 732.5 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 148.292249815985 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Ser476Asn Rv1129c_p.Ser476Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Ser480Pro Rv1129c_p.Ser480Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 19 0 19 0 24 4002 18511 0 0 0.000921334294721226 0.998705152414351 0.99807397809504 0.999170196040018 0 0 0.142473597722525 0 0 0.176466911806965 0 0 0.142473597722525 0 0 0.991671794073686 0.035882670717124 38 1798 False False 0 0 0.768917145198219 0 0 0.000921334294721226 0.998705152414351 0.99807397809504 0.999170196040018 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Thr12Met Rv1129c_p.Thr12Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 1 4 1 6 4001 18529 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999676288103587 0.999295549654279 0.999881194471086 0.142857142857142 0.00361029686190058 0.578723197043195 0.2 0.00505076337946806 0.716417936118089 0.142857142857142 0.00361029686190058 0.578723197043195 1.15777305673581 0.0235034390589406 11.7068750583276 1 732.5 1798 False False 0.771848704490544 0.0167759984530013 6.36465776860659 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999676288103587 0.999295549654279 0.999881194471086 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 1742 6636 0 0 0.00211537106925253 0.999397590361445 0.998458316867766 0.999835840034063 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.22646396172322 1 345 886 False False 0 0 0 0 0 0 0 0 0 5.77543554850383 0 0 0.00211537106925253 0.999397590361445 0.998458316867766 0.999835840034063 20 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Thr131Ala Rv1129c_p.Thr131Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 4000 18534 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 0.999946048017264 0.999699435860871 0.999998634054993 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 180.210207769499 1 732.5 1798 False False 9.267 0.482236652039982 544.73752523911 0 0 0.000921794749483055 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 841 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 3 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Thr131Ile Rv1129c_p.Thr131Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Thr131Pro Rv1129c_p.Thr131Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 18 2 16 9 22 3993 18513 0.00224887556221889 0.00102882864885218 0.00426475484372027 0.998813056379822 0.998203501328592 0.99925600395763 0.290322580645161 0.142228529097525 0.480360658228909 0.111111111111111 0.0137512156643644 0.347120438608672 0.0833333333333333 0.0102563412812501 0.269972801557603 0.579545454545454 0.0646196844787986 2.46664086043254 0.756463635898737 186 1798 False False 1.89669421487603 0.768148714090839 4.28965636098168 0.000500625782227784 6.06338559216711e-05 0.00180725030378026 0.998813056379822 0.998203501328592 0.99925600395763 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 2 7 1740 6633 0.00114810562571756 0.000139071172424607 0.00414113746933503 0.99894578313253 0.997829124235982 0.999576048424705 0.222222222222222 0.0281449734778982 0.600093573716312 0 0 0.602364635616474 0 0 0.409616397225003 0 0 5.77946430253021 0.586680966254035 83 886 False False 0 0 0 0 0 0 0 1.08916256157635 0.110286408985404 5.72783919099986 0 0 0.00211779995375925 0.99894578313253 0.997829124235982 0.999576048424705 37 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Thr187Asn Rv1129c_p.Thr187Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Thr215Ala Rv1129c_p.Thr215Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 4001 18533 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999892096034529 0.999610268708724 0.999986932062044 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 180.155600359953 1 732.5 1798 False False 2.31604598850287 0.0392471382871788 44.494064095996 0 0 0.000921564464586207 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Thr261Pro Rv1129c_p.Thr261Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 180.0913296367 1 732.5 1798 False False 0 0 7.01683899052165 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 148.269965029351 1 345 886 False False 0 0 0 0 0 0 0 0 0 9.22785363871091 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 23 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Thr2Ala Rv1129c_p.Thr2Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 6 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Thr2Met Rv1129c_p.Thr2Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1715 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Thr323Ala Rv1129c_p.Thr323Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 12 1 11 4 11 3998 18524 0.000999500249875062 0.000272395196018755 0.00255712257980299 0.99940652818991 0.998938363693644 0.999703704968061 0.266666666666666 0.0778715462910436 0.551003241036971 0.0833333333333333 0.00210759323186022 0.384796165150944 0.0833333333333333 0.00210759323186022 0.384796165150944 0.421210605302651 0.00978671113968974 2.8995961314217 0.705271454561327 184 1798 False False 1.6848424212106 0.39106128905354 5.68897264047661 0.000250062515628907 6.33101471380292e-06 0.00139246303880997 0.99940652818991 0.998938363693644 0.999703704968061 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 9 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Thr430Pro Rv1129c_p.Thr430Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 3 4001 18532 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999838144051794 0.999527061819887 0.99996662016845 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 24.6676166728131 1 732.5 1798 False False 1.5439473464967 0.0294026895471131 19.2327580431529 0 0 0.000921564464586207 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 1741 6639 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999849397590361 0.999161185884076 0.99999618708438 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 148.399526333966 1 596 886 False False 0 0 0 0 0 0 0 3.81332567489948 0.0485516368820753 298.645085154332 0 0 0.00211658481469046 0.999849397590361 0.999161185884076 0.99999618708438 4 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Thr439Ala Rv1129c_p.Thr439Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1710 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 849 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Thr44Ile Rv1129c_p.Thr44Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1657 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Thr453Met Rv1129c_p.Thr453Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1680 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Trp232Gly Rv1129c_p.Trp232Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 17 1 16 3 22 3999 18513 0.000749625187406296 0.000154617422592445 0.00218914487959466 0.998813056379822 0.998203501328592 0.99925600395763 0.12 0.0254653966477332 0.312190307286235 0.0588235294117647 0.00148817439126663 0.28688939666722 0.0434782608695652 0.0011001686304415 0.21948660745348 0.289337959489872 0.00690136009451029 1.86355882950338 0.338415561134787 106 1798 False False 0.631282820705176 0.120913688938085 2.10282241658799 0.00025 6.32943196513345e-06 0.00139211512196626 0.998813056379822 0.998203501328592 0.99925600395763 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 1 7 2 8 1740 6632 0.00114810562571756 0.000139071172424607 0.00414113746933503 0.998795180722891 0.997627413333175 0.999479705585957 0.2 0.0252107263268333 0.556095462307641 0.125 0.0031597235312519 0.526509670875206 0.111111111111111 0.00280913674659921 0.482496514917337 0.544499178981937 0.0120781368952263 4.24305095323052 1 345 886 False False 0 0 0 0 0 0 0 0.95287356321839 0.0984874355079053 4.78069717437015 0.000574382538770821 1.45420010902056e-05 0.00319605610685329 0.998795180722891 0.997627413333175 0.999479705585957 12 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Trp366Cys Rv1129c_p.Trp366Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 4000 18535 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 1 0.999800997443015 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1716 1798 False False Inf 0.869940791113183 Inf 0 0 0.000921794749483055 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 852 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Trp366Gly Rv1129c_p.Trp366Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1704 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Tyr137Asp Rv1129c_p.Tyr137Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 5 4001 18530 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999730240086323 0.999370583585258 0.99991240407437 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.841886116991581 0 0 0.521823750104981 0 0 24.6649561389967 1 198.5 1798 False False 0.926268432891777 0.0195789744788398 8.28271147593069 0 0 0.000921564464586207 0.999730240086323 0.999370583585258 0.99991240407437 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 839 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 7 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Tyr137Cys Rv1129c_p.Tyr137Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 4000 18535 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 1 0.999800997443015 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1709 1798 False False Inf 0.869940791113183 Inf 0 0 0.000921794749483055 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 1740 6640 0.00114810562571756 0.000139071172424607 0.00414113746933503 1 0.999444600156968 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 848 886 False False 0 0 0 0 0 0 0 Inf 0.716065670156237 Inf 0 0 0.00211779995375925 1 0.999444600156968 1 3 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Tyr137His Rv1129c_p.Tyr137His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1649 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 817 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 3 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Tyr137Ser Rv1129c_p.Tyr137Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1693 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Tyr462Cys Rv1129c_p.Tyr462Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 4 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Tyr462His Rv1129c_p.Tyr462His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1722 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Val116Phe Rv1129c_p.Val116Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 4001 18532 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999838144051794 0.999527061819887 0.99996662016845 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 11.2132358700375 1 732.5 1798 False False 1.5439473464967 0.0294026895471131 19.2327580431529 0 0 0.000921564464586207 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Val226Leu Rv1129c_p.Val226Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Val259Ala Rv1129c_p.Val259Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 5 4002 18530 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 11.2092253162358 1 732.5 1798 False False 0 0 5.05471226039473 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 148.292249815985 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 4 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Val272Ile Rv1129c_p.Val272Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Val317Ala Rv1129c_p.Val317Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Val337Ala Rv1129c_p.Val337Ala 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 3 4000 18532 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 0.999838144051794 0.999527061819887 0.99996662016845 0.4 0.0527449505263169 0.853367200365326 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1658 1798 False False 3.08866666666666 0.257877592435781 26.9864148134858 0 0 0.000921794749483055 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 10 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Val337Phe Rv1129c_p.Val337Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Val34Leu Rv1129c_p.Val34Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 7.01683899052165 1 732.5 1798 False False 0 0 7.01683899052165 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.22785363871091 1 345 886 False False 0 0 0 0 0 0 0 0 0 9.22785363871091 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Val414Ile Rv1129c_p.Val414Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Val59Ala Rv1129c_p.Val59Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.118748254282209 Inf 0.177582534611288 85 1798 False False 4.63234191452137 0.0589984289392935 362.546724531758 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 1 1741 6639 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999849397590361 0.999161185884076 0.99999618708438 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0977213705556986 Inf 0.20785109175516 39 886 False False 0 0 0 0 0 0 0 3.81332567489948 0.0485516368820753 298.645085154332 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999849397590361 0.999161185884076 0.99999618708438 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Val6Ile Rv1129c_p.Val6Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 2 8 4000 18527 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 0.999568384138117 0.999149722782159 0.999813641077243 0.2 0.0252107263268333 0.556095462307641 0 0 0.4592581264399 0 0 0.369416647552819 0 0 3.93540154684776 0.599058930386777 158 1798 False False 1.1579375 0.119723432399326 5.8056993414884 0 0 0.000921794749483055 0.999568384138117 0.999149722782159 0.999813641077243 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 6 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Val85Met Rv1129c_p.Val85Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Val97Ile Rv1129c_p.Val97Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1720 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 855 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Val9fs Rv1129c_p.Val9fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv1129c p.Val9Met Rv1129c_p.Val9Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 180.110710654533 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 836 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c c.1002C>T Rv2477c_c.1002C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.1030T>C Rv2477c_c.1030T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.1068C>T Rv2477c_c.1068C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 4 4001 18531 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999784192069058 0.999447539013843 0.999941196572055 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.15789802549362 0.0235059760051305 11.7081385811536 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.1086A>G Rv2477c_c.1086A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 4 4000 18531 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 0.999784192069058 0.999447539013843 0.999941196572055 0.333333333333333 0.0432718682927417 0.777221904496487 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.316375 0.209452463855679 16.1672355802828 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 4 1740 6636 0.00114810562571756 0.000139071172424607 0.00414113746933503 0.999397590361445 0.998458316867766 0.999835840034063 0.333333333333333 0.0432718682927417 0.777221904496487 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.90689655172413 0.172334634649247 13.3169802580519 NA NA NA NA NA NA 31 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.1101C>T Rv2477c_c.1101C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 1 4000 18534 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 0.999946048017264 0.999699435860871 0.999998634054993 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 9.267 0.482236652039982 544.73752523911 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 1740 6640 0.00114810562571756 0.000139071172424607 0.00414113746933503 1 0.999444600156968 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.716065670156237 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.1104C>T Rv2477c_c.1104C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 11.2104345733627 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.1116A>G Rv2477c_c.1116A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 18 4002 18517 0 0 0.000921334294721226 0.999028864310763 0.998465619515959 0.999424345094191 0 0 0.185301968137852 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.05295108465467 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 6 1742 6634 0 0 0.00211537106925253 0.999096385542168 0.998034257105878 0.999668319522948 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.23733664541029 NA NA NA NA NA NA 128 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.1122C>T Rv2477c_c.1122C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.1152C>A Rv2477c_c.1152C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.1152C>G Rv2477c_c.1152C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.1167G>T Rv2477c_c.1167G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.1170C>T Rv2477c_c.1170C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.1176C>T Rv2477c_c.1176C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.1212G>A Rv2477c_c.1212G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 20.3050873563561 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.1215T>C Rv2477c_c.1215T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.1221G>A Rv2477c_c.1221G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.1269G>A Rv2477c_c.1269G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.1275C>T Rv2477c_c.1275C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.-12C>A Rv2477c_c.-12C>A 2 upstream_gene_variant 2784054 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c c.1323T>C Rv2477c_c.1323T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.1383C>A Rv2477c_c.1383C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.1401C>T Rv2477c_c.1401C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.1413C>T Rv2477c_c.1413C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.1434G>C Rv2477c_c.1434G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.1443G>C Rv2477c_c.1443G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.1497C>T Rv2477c_c.1497C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.1512C>T Rv2477c_c.1512C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.1518C>T Rv2477c_c.1518C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.1521G>T Rv2477c_c.1521G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 4001 18533 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999892096034529 0.999610268708724 0.999986932062044 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.31604598850287 0.0392471382871788 44.494064095996 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 1741 6639 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999849397590361 0.999161185884076 0.99999618708438 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.81332567489948 0.0485516368820753 298.645085154332 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.1542T>C Rv2477c_c.1542T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.1545C>T Rv2477c_c.1545C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 291 2145 3711 16390 0.0727136431784108 0.0648579475225142 0.0811997758252524 0.884272997032641 0.879580280711873 0.888844781555269 0.119458128078817 0.106836833963883 0.133002100010523 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.599175009845988 0.525625464247996 0.681193761476031 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 147 892 1595 5748 0.0843857634902411 0.0717541296738133 0.0984370719015528 0.865662650602409 0.857224348770874 0.873778381101061 0.141482194417709 0.120848273907274 0.164170066973464 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 0 0.593893473157428 0.491111819664655 0.714493118162069 NA NA NA NA NA NA 3626 5) Not assoc w R Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.156C>G Rv2477c_c.156C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.1587C>T Rv2477c_c.1587C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.1605C>T Rv2477c_c.1605C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 8 4002 18527 0 0 0.000921334294721226 0.999568384138117 0.999149722782159 0.999813641077243 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.7132714326819 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.1620C>T Rv2477c_c.1620C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.1638A>G Rv2477c_c.1638A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.1659C>T Rv2477c_c.1659C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.1663C>T Rv2477c_c.1663C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.1674C>T Rv2477c_c.1674C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.201C>A Rv2477c_c.201C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.-20C>G Rv2477c_c.-20C>G 2 upstream_gene_variant 2784062 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1793 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c c.219G>A Rv2477c_c.219G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.-25A>C Rv2477c_c.-25A>C 2 upstream_gene_variant 2784067 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c c.309C>T Rv2477c_c.309C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01683899052165 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.312C>T Rv2477c_c.312C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01683899052165 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 1742 6636 0 0 0.00211537106925253 0.999397590361445 0.998458316867766 0.999835840034063 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 5.77543554850383 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.318C>T Rv2477c_c.318C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 9 4002 18526 0 0 0.000921334294721226 0.999514432155381 0.999078442003892 0.999777944189974 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.34636960420997 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 6 1742 6634 0 0 0.00211537106925253 0.999096385542168 0.998034257105878 0.999668319522948 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.23733664541029 NA NA NA NA NA NA 13 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.-31A>G Rv2477c_c.-31A>G 2 upstream_gene_variant 2784073 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c c.352C>T Rv2477c_c.352C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.387G>A Rv2477c_c.387G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.393C>T Rv2477c_c.393C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 11 4001 18524 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.99940652818991 0.998938363693644 0.999703704968061 0.0833333333333333 0.00210759323186022 0.384796165150944 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.420894776305923 0.00977937778460056 2.89742168554269 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 8 1741 6632 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.998795180722891 0.997627413333175 0.999479705585957 0.111111111111111 0.00280913674659921 0.482496514917337 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.47616312464101 0.010728436160514 3.55589199099794 NA NA NA NA NA NA 15 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.396C>T Rv2477c_c.396C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.417G>A Rv2477c_c.417G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.429G>A Rv2477c_c.429G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.-44G>A Rv2477c_c.-44G>A 2 upstream_gene_variant 2784086 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1733 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c c.453G>A Rv2477c_c.453G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 20.3050873563561 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.45C>T Rv2477c_c.45C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.489C>T Rv2477c_c.489C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.48C>T Rv2477c_c.48C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.492G>A Rv2477c_c.492G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.-4C>A Rv2477c_c.-4C>A 2 upstream_gene_variant 2784046 NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1728 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c c.-4C>T Rv2477c_c.-4C>T 2 upstream_gene_variant 2784046 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c c.538C>T Rv2477c_c.538C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.540G>A Rv2477c_c.540G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.541T>C Rv2477c_c.541T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 15 14 3987 18521 0.00374812593703148 0.00209926869551387 0.00617444031818382 0.999244672241704 0.998733012789936 0.999586995715357 0.517241379310344 0.325314996361456 0.705514417048159 NA NA NA NA NA NA NA NA NA NA NA NA False False 4.97715790605181 2.23761616707842 11.1427847824984 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 8 4 1734 6636 0.00459242250287026 0.00198470392380438 0.00902874874953196 0.999397590361445 0.998458316867766 0.999835840034063 0.666666666666666 0.348875506418814 0.900753908850416 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 7.65397923875432 2.0469587107827 34.7644159688777 NA NA NA NA NA NA 15 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.546G>A Rv2477c_c.546G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.558G>A Rv2477c_c.558G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.-55G>A Rv2477c_c.-55G>A 2 upstream_gene_variant 2784097 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c c.585G>A Rv2477c_c.585G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.612C>T Rv2477c_c.612C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.615C>T Rv2477c_c.615C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.618C>T Rv2477c_c.618C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01683899052165 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.22785363871091 NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.627C>T Rv2477c_c.627C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.639C>T Rv2477c_c.639C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.655C>T Rv2477c_c.655C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.69C>T Rv2477c_c.69C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.702C>A Rv2477c_c.702C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.708C>A Rv2477c_c.708C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.708C>T Rv2477c_c.708C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.723C>T Rv2477c_c.723C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 11.2104345733627 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.22785363871091 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.-72T>C Rv2477c_c.-72T>C 2 upstream_gene_variant 2784114 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c c.-73C>G Rv2477c_c.-73C>G 2 upstream_gene_variant 2784115 1 3 0 3 1 3 4001 18532 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999838144051794 0.999527061819887 0.99996662016845 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 11.2132358700375 1 732.5 1798 False False 1.5439473464967 0.0294026895471131 19.2327580431529 0 0 0.000921564464586207 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.22785363871091 1 345 886 False False 0 0 0 0 0 0 0 0 0 9.22785363871091 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c c.753G>A Rv2477c_c.753G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.-75G>A Rv2477c_c.-75G>A 2 upstream_gene_variant 2784117 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1772 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c c.762G>A Rv2477c_c.762G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.-76C>G Rv2477c_c.-76C>G 2 upstream_gene_variant 2784118 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c c.-78delG Rv2477c_c.-78delG 2 upstream_gene_variant 2784119 NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1794 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c c.801C>T Rv2477c_c.801C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 11.2104345733627 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.813T>G Rv2477c_c.813T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.-81G>A Rv2477c_c.-81G>A 2 upstream_gene_variant 2784123 1 10 0 10 0 14 4002 18521 0 0 0.000921334294721226 0.999244672241704 0.998733012789936 0.999586995715357 0 0 0.231635761650116 0 0 0.30849710781876 0 0 0.231635761650116 0 0 2.06565103217764 0.226223278367346 89 1798 False False 0 0 1.39588267491558 0 0 0.000921334294721226 0.999244672241704 0.998733012789936 0.999586995715357 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 5 1742 6635 0 0 0.00211537106925253 0.999246987951807 0.99824360331506 0.999755455269461 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 9.22507428438899 1 345 886 False False 0 0 0 0 0 0 0 0 0 4.16029237021718 0 0 0.00211537106925253 0.999246987951807 0.99824360331506 0.999755455269461 15 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c c.81T>C Rv2477c_c.81T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 4.63234191452137 0.0589984289392935 362.546724531758 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.831C>T Rv2477c_c.831C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 11.2104345733627 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 20.3050873563561 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.846C>G Rv2477c_c.846C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.-86G>A Rv2477c_c.-86G>A 2 upstream_gene_variant 2784128 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c c.879G>A Rv2477c_c.879G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.894G>C Rv2477c_c.894G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.897G>A Rv2477c_c.897G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.-8A>G Rv2477c_c.-8A>G 2 upstream_gene_variant 2784050 1 5 0 5 0 8 4002 18527 0 0 0.000921334294721226 0.999568384138117 0.999149722782159 0.999813641077243 0 0 0.369416647552819 0 0 0.521823750104981 0 0 0.369416647552819 0 0 5.05389397735184 0.593746675173903 125 1798 False False 0 0 2.7132714326819 0 0 0.000921334294721226 0.999568384138117 0.999149722782159 0.999813641077243 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 28 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c c.900G>A Rv2477c_c.900G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.909G>A Rv2477c_c.909G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.90G>A Rv2477c_c.90G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.918C>T Rv2477c_c.918C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.948C>G Rv2477c_c.948C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 50 3999 18485 0.000749625187406296 0.000154617422592445 0.00218914487959466 0.997302400863231 0.996445079615487 0.997997147192941 0.0566037735849056 0.0118287188591336 0.156629462172374 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.277344336084021 0.0553125336277268 0.859186854277388 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 3 1741 6637 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999548192771084 0.998680200855815 0.999906816794257 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.27072563660731 0.0241917279459833 15.8348342618437 NA NA NA NA NA NA 55 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.96C>T Rv2477c_c.96C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c c.9G>A Rv2477c_c.9G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 7 4002 18528 0 0 0.000921334294721226 0.999622336120852 0.999222023868969 0.999848146482689 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.21342445526953 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2477c LoF Rv2477c_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1798 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Ala134Val Rv2477c_p.Ala134Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 180.110710654533 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Ala139Val Rv2477c_p.Ala139Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Ala260Val Rv2477c_p.Ala260Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Ala277Thr Rv2477c_p.Ala277Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1782 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Ala2Val Rv2477c_p.Ala2Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1729 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Ala335Thr Rv2477c_p.Ala335Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 11.2104345733627 1 732.5 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Ala392Thr Rv2477c_p.Ala392Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1743 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Ala392Val Rv2477c_p.Ala392Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Ala424Val Rv2477c_p.Ala424Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 4002 18530 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 7.01646036669751 1 198.5 1798 False False 0 0 5.05471226039473 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Ala454Val Rv2477c_p.Ala454Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1753 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 865 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Ala492Asp Rv2477c_p.Ala492Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1752 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 864 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Ala52Thr Rv2477c_p.Ala52Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1769 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Ala531Pro Rv2477c_p.Ala531Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Ala68Val Rv2477c_p.Ala68Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 7.01683899052165 1 732.5 1798 False False 0 0 7.01683899052165 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 1742 6636 0 0 0.00211537106925253 0.999397590361445 0.998458316867766 0.999835840034063 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.77543554850383 0.5866324014095 78.5 886 False False 0 0 0 0 0 0 0 0 0 5.77543554850383 0 0 0.00211537106925253 0.999397590361445 0.998458316867766 0.999835840034063 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Arg149Cys Rv2477c_p.Arg149Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Arg231Leu Rv2477c_p.Arg231Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Arg251Pro Rv2477c_p.Arg251Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1779 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 878 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Arg257Ser Rv2477c_p.Arg257Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1773 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 875 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Arg316His Rv2477c_p.Arg316His 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 11.2104345733627 1 732.5 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Arg316Ser Rv2477c_p.Arg316Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 180.110710654533 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 870 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Arg346Cys Rv2477c_p.Arg346Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1783 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 19 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Arg450Lys Rv2477c_p.Arg450Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1757 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Arg450Thr Rv2477c_p.Arg450Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1764 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 12 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Arg499Cys Rv2477c_p.Arg499Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1795 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Arg504Cys Rv2477c_p.Arg504Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 180.101020147088 1 732.5 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Arg553His Rv2477c_p.Arg553His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Arg86His Rv2477c_p.Arg86His 2 missense_variant (see "Genomic_coordinates" sheet) 1 31 2 29 4 40 3998 18495 0.000999500249875062 0.000272395196018755 0.00255712257980299 0.997841920690585 0.997062455780841 0.998457802661391 0.0909090909090909 0.0253284217034507 0.216686589465274 0.064516129032258 0.0079109834618547 0.214216157163402 0.0476190476190476 0.00581982483550999 0.161641959691653 0.319038829759707 0.036875962064189 1.26204545918804 0.153266612557854 58 1798 False False 0.462606303151575 0.120148544814606 1.2807881931522 0.0005 6.05580564205145e-05 0.00180499271626403 0.997841920690585 0.997062455780841 0.998457802661391 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 13 1 12 2 15 1740 6625 0.00114810562571756 0.000139071172424607 0.00414113746933503 0.997740963855421 0.996276796314206 0.998735100547745 0.117647058823529 0.0145793168403025 0.36440916210125 0.0769230769230769 0.00194562849734675 0.360297435267877 0.0625 0.00158111172276588 0.302320738434531 0.317289272030651 0.0074216732093744 2.1473873195179 0.490093902684328 72 886 False False 0 0 0 0 0 0 0 0.507662835249042 0.0562868651172779 2.18641735448743 0.000574382538770821 1.45420010902056e-05 0.00319605610685329 0.997740963855421 0.996276796314206 0.998735100547745 50 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Asn80Lys Rv2477c_p.Asn80Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1759 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Asn88Ser Rv2477c_p.Asn88Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Asp22Asn Rv2477c_p.Asp22Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Asp230Gly Rv2477c_p.Asp230Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Asp339Glu Rv2477c_p.Asp339Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 24 4002 18511 0 0 0.000921334294721226 0.998705152414351 0.99807397809504 0.999170196040018 0 0 0.142473597722525 NA NA NA 0 0 0.142473597722525 NA NA NA NA 1786 1798 False False 0 0 0.768917145198219 0 0 0.000921334294721226 0.998705152414351 0.99807397809504 0.999170196040018 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 880 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 4 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Asp503Asn Rv2477c_p.Asp503Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Asp503Gly Rv2477c_p.Asp503Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 7.01683899052165 1 732.5 1798 False False 0 0 7.01683899052165 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Asp515His Rv2477c_p.Asp515His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1746 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Asp516Glu Rv2477c_p.Asp516Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Asp516His Rv2477c_p.Asp516His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1780 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Asp517Ala Rv2477c_p.Asp517Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 2 4000 18533 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 0.999892096034529 0.999610268708724 0.999986932062044 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 180.20051244703 1 732.5 1798 False False 4.63325 0.335715582549978 63.989229087488 0 0 0.000921794749483055 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Asp517Asn Rv2477c_p.Asp517Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Asp543Tyr Rv2477c_p.Asp543Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 180.110710654533 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Asp55Ala Rv2477c_p.Asp55Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 4002 18529 0 0 0.000921334294721226 0.999676288103587 0.999295549654279 0.999881194471086 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.93385874811763 0.599069212767884 166.5 1798 False False 0 0 3.93385874811763 0 0 0.000921334294721226 0.999676288103587 0.999295549654279 0.999881194471086 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.22785363871091 1 345 886 False False 0 0 0 0 0 0 0 0 0 9.22785363871091 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Asp95Asn Rv2477c_p.Asp95Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Asp95Gly Rv2477c_p.Asp95Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Gln140Glu Rv2477c_p.Gln140Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1784 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Gln196His Rv2477c_p.Gln196His 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 4001 18532 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999838144051794 0.999527061819887 0.99996662016845 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 11.2132358700375 1 732.5 1798 False False 1.5439473464967 0.0294026895471131 19.2327580431529 0 0 0.000921564464586207 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Gln417His Rv2477c_p.Gln417His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1770 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Gln74His Rv2477c_p.Gln74His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1730 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Glu105Lys Rv2477c_p.Glu105Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1775 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Glu117Ala Rv2477c_p.Glu117Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Glu120Asp Rv2477c_p.Glu120Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Glu127Asp Rv2477c_p.Glu127Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Glu128Asp Rv2477c_p.Glu128Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Glu224Lys Rv2477c_p.Glu224Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Glu238Val Rv2477c_p.Glu238Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 180.16529327284 1 732.5 1798 False False 4.63234191452137 0.0589984289392935 362.546724531758 0 0 0.000921564464586207 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Glu250Ala Rv2477c_p.Glu250Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Glu269Lys Rv2477c_p.Glu269Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1776 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 876 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Glu308Lys Rv2477c_p.Glu308Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1761 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 871 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Glu476Ala Rv2477c_p.Glu476Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Glu538_Leu540delinsVal Rv2477c_p.Glu538_Leu540delinsVal 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Glu81Lys Rv2477c_p.Glu81Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Glu90Asp Rv2477c_p.Glu90Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Glu91Asp Rv2477c_p.Glu91Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1747 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 861 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Glu91Gly Rv2477c_p.Glu91Gly 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1738 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Gly123Asp Rv2477c_p.Gly123Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Gly162Ser Rv2477c_p.Gly162Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1734 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Gly207Asp Rv2477c_p.Gly207Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Gly207Cys Rv2477c_p.Gly207Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Gly207Ser Rv2477c_p.Gly207Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Gly256Ser Rv2477c_p.Gly256Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Gly314Arg Rv2477c_p.Gly314Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1768 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Gly31Ser Rv2477c_p.Gly31Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1787 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 881 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Gly395Asp Rv2477c_p.Gly395Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1777 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Gly41Glu Rv2477c_p.Gly41Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 291 2 289 12 307 3990 18228 0.00299850074962518 0.00155029923838043 0.00523191326268615 0.983436741300242 0.981494648557955 0.98522494828325 0.0376175548589341 0.0195859732728268 0.0647878465775143 0.00687285223367697 0.000833420726231873 0.0246052256733874 0.00647249190938511 0.000784812205436928 0.0231840323648268 0.0316153706064469 0.00383961496203009 0.115338068130808 5.89194751262471e-22 8 1798 True False 0.178570204011657 0.0911449207575417 0.316921588260839 0.000501002004008016 6.06794267727033e-05 0.00180860756904713 0.983436741300242 0.981494648557955 0.98522494828325 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 4 1741 6636 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999397590361445 0.998458316867766 0.999835840034063 0.2 0.00505076337946806 0.716417936118089 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.2317643698701 1 98.5 886 False False 0 0 0 0 0 0 0 0.952900631820792 0.0193382014380594 9.63481227974485 0 0 0.00211658481469046 0.999397590361445 0.998458316867766 0.999835840034063 70 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Gly433Val Rv2477c_p.Gly433Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Gly441Ala Rv2477c_p.Gly441Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 11 0 11 0 11 4002 18524 0 0 0.000921334294721226 0.99940652818991 0.998938363693644 0.999703704968061 0 0 0.284914152918154 0 0 0.284914152918154 0 0 0.284914152918154 0 0 1.84512569595635 0.231452145338353 94.5 1798 False False 0 0 1.84512569595635 0 0 0.000921334294721226 0.99940652818991 0.998938363693644 0.999703704968061 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 0 9 1742 6631 0 0 0.00211537106925253 0.998644578313253 0.997428553721748 0.999380033497835 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.336267116879942 0 0 1.93068643684555 0.218936430493458 46.5 886 False False 0 0 0 0 0 0 0 0 0 1.93068643684555 0 0 0.00211537106925253 0.998644578313253 0.997428553721748 0.999380033497835 24 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Gly460Ser Rv2477c_p.Gly460Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Gly527Ser Rv2477c_p.Gly527Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1754 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 866 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Gly530Asp Rv2477c_p.Gly530Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Gly558Asp Rv2477c_p.Gly558Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Gly87Arg Rv2477c_p.Gly87Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1758 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 869 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Gly87Ser Rv2477c_p.Gly87Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1796 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.His189Tyr Rv2477c_p.His189Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 3 8 3999 18527 0.000749625187406296 0.000154617422592445 0.00218914487959466 0.999568384138117 0.999149722782159 0.999813641077243 0.272727272727272 0.0602177341729066 0.609742559572421 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1744 1798 False False 1.73734058514628 0.296727957807784 7.2422944952005 0 0 0.000922025149498025 0.999568384138117 0.999149722782159 0.999813641077243 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 1742 6634 0 0 0.00211537106925253 0.999096385542168 0.998034257105878 0.999668319522948 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 860 886 False False 0 0 0 0 0 0 0 0 0 3.23733664541029 0 0 0.00211537106925253 0.999096385542168 0.998034257105878 0.999668319522948 16 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.His201Asp Rv2477c_p.His201Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1762 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.His548Arg Rv2477c_p.His548Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1739 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Ile20Val Rv2477c_p.Ile20Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Ile311Met Rv2477c_p.Ile311Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1750 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 863 886 False False 0 0 0 0 0 0 0 0 0 9.22785363871091 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Ile396Val Rv2477c_p.Ile396Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1791 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 884 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Ile413Val Rv2477c_p.Ile413Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Ile464Val Rv2477c_p.Ile464Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1755 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 867 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Leu109Phe Rv2477c_p.Leu109Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Leu148Pro Rv2477c_p.Leu148Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Leu198Val Rv2477c_p.Leu198Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Leu288Val Rv2477c_p.Leu288Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 4 12 3998 18523 0.000999500249875062 0.000272395196018755 0.00255712257980299 0.999352576207175 0.998869354319296 0.999665423355947 0.25 0.0726620382528822 0.523770819896127 0 0 0.521823750104981 0 0 0.264648469397051 0 0 5.05785969085661 0.593782410259735 151 1798 False False 1.54435551108887 0.362831077889114 5.09887764651292 0 0 0.000922255664717455 0.999352576207175 0.998869354319296 0.999665423355947 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 9 1741 6631 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.998644578313253 0.997428553721748 0.999380033497835 0.1 0.00252857854446178 0.445016117028195 0 0 0.707598226178713 0 0 0.336267116879942 0 0 9.224811993684 1 345 886 False False 0 0 0 0 0 0 0 0.423192290509924 0.00965311683757768 3.05769055642519 0 0 0.00211658481469046 0.998644578313253 0.997428553721748 0.999380033497835 26 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Leu327His Rv2477c_p.Leu327His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 180.110710654533 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Leu327Phe Rv2477c_p.Leu327Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 6 4002 18529 0 0 0.000921334294721226 0.999676288103587 0.999295549654279 0.999881194471086 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1785 1798 False False 0 0 3.93385874811763 0 0 0.000921334294721226 0.999676288103587 0.999295549654279 0.999881194471086 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Leu370Arg Rv2477c_p.Leu370Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Leu473Arg Rv2477c_p.Leu473Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Leu481Val Rv2477c_p.Leu481Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Leu486Arg Rv2477c_p.Leu486Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Leu540Phe Rv2477c_p.Leu540Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 24.660125576486 1 198.5 1798 False False 0 0 7.01683899052165 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Leu54Ser Rv2477c_p.Leu54Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1788 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 882 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Leu73Pro Rv2477c_p.Leu73Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1726 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Lys278Asn Rv2477c_p.Lys278Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Lys303Glu Rv2477c_p.Lys303Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 180.110710654533 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Lys33Asn Rv2477c_p.Lys33Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 4002 18530 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 5.05471226039473 0.593754047365944 137.5 1798 False False 0 0 5.05471226039473 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 1742 6636 0 0 0.00211537106925253 0.999397590361445 0.998458316867766 0.999835840034063 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.77543554850383 0.5866324014095 78.5 886 False False 0 0 0 0 0 0 0 0 0 5.77543554850383 0 0 0.00211537106925253 0.999397590361445 0.998458316867766 0.999835840034063 5 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Lys379Asn Rv2477c_p.Lys379Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 7.01683899052165 1 732.5 1798 False False 0 0 7.01683899052165 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Lys385Thr Rv2477c_p.Lys385Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Lys458Asn Rv2477c_p.Lys458Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1748 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 862 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Lys458Glu Rv2477c_p.Lys458Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1797 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 885 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Met51Val Rv2477c_p.Met51Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Phe306Ser Rv2477c_p.Phe306Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Phe429Leu Rv2477c_p.Phe429Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Pro186Leu Rv2477c_p.Pro186Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Pro236His Rv2477c_p.Pro236His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1735 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Pro312Gln Rv2477c_p.Pro312Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Pro355Ser Rv2477c_p.Pro355Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1742 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Pro39Ser Rv2477c_p.Pro39Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1736 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 22 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Pro421Leu Rv2477c_p.Pro421Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1756 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 868 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Pro434Gln Rv2477c_p.Pro434Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 5 1 3997 18534 0.00124937531234382 0.000405789275012681 0.0029131967931525 0.999946048017264 0.999699435860871 0.999998634054993 0.833333333333333 0.358765421002325 0.99578925548551 NA NA NA 0 0 0.975 NA NA NA NA 1778 1798 False False 23.1848886664998 2.59300776862752 1089.88528001552 0 0 0.00092248629522778 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 1738 6640 0.00229621125143513 0.000625983621299944 0.00586868734668228 1 0.999444600156968 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 877 886 False False 0 0 0 0 0 0 0 Inf 2.51879846731155 Inf 0 0 0.00212023442240146 1 0.999444600156968 1 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Pro489Leu Rv2477c_p.Pro489Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1789 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Pro489Ser Rv2477c_p.Pro489Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1737 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 858 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Pro547Leu Rv2477c_p.Pro547Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Pro77Thr Rv2477c_p.Pro77Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1731 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Pro78Ala Rv2477c_p.Pro78Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Pro78Ser Rv2477c_p.Pro78Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Ser176Ala Rv2477c_p.Ser176Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1745 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Ser176Pro Rv2477c_p.Ser176Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1740 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 859 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Ser242Pro Rv2477c_p.Ser242Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Ser27Gly Rv2477c_p.Ser27Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 7 4002 18528 0 0 0.000921334294721226 0.999622336120852 0.999222023868969 0.999848146482689 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1732 1798 False False 0 0 3.21342445526953 0 0 0.000921334294721226 0.999622336120852 0.999222023868969 0.999848146482689 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Ser377Cys Rv2477c_p.Ser377Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1741 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Ser407Ala Rv2477c_p.Ser407Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1771 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 874 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Ser427Leu Rv2477c_p.Ser427Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Ser480Leu Rv2477c_p.Ser480Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1765 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Ter559Glnext*? Rv2477c_p.Ter559Glnext*? 2 stop_lost (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Thr187Ala Rv2477c_p.Thr187Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1774 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Thr362Ala Rv2477c_p.Thr362Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1792 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Thr372Lys Rv2477c_p.Thr372Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 12 4002 18523 0 0 0.000921334294721226 0.999352576207175 0.998869354319296 0.999665423355947 0 0 0.264648469397051 NA NA NA 0 0 0.264648469397051 NA NA NA NA 1766 1798 False False 0 0 1.66656583988199 0 0 0.000921334294721226 0.999352576207175 0.998869354319296 0.999665423355947 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 873 886 False False 0 0 0 0 0 0 0 0 0 9.22785363871091 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 70 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Thr505Met Rv2477c_p.Thr505Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1749 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Thr551Ile Rv2477c_p.Thr551Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Thr7Met Rv2477c_p.Thr7Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 180.101020147088 1 732.5 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Trp524Arg Rv2477c_p.Trp524Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Tyr114Ser Rv2477c_p.Tyr114Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Val168Ala Rv2477c_p.Val168Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1781 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 879 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Val195Met Rv2477c_p.Val195Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Val313Phe Rv2477c_p.Val313Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 4001 18533 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999892096034529 0.999610268708724 0.999986932062044 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 180.155600359953 1 732.5 1798 False False 2.31604598850287 0.0392471382871788 44.494064095996 0 0 0.000921564464586207 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Val320Met Rv2477c_p.Val320Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 7.01683899052165 1 732.5 1798 False False 0 0 7.01683899052165 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 1742 6636 0 0 0.00211537106925253 0.999397590361445 0.998458316867766 0.999835840034063 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.77543554850383 0.5866324014095 78.5 886 False False 0 0 0 0 0 0 0 0 0 5.77543554850383 0 0 0.00211537106925253 0.999397590361445 0.998458316867766 0.999835840034063 5 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Val322Ile Rv2477c_p.Val322Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Val324Ala Rv2477c_p.Val324Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Val324Ile Rv2477c_p.Val324Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1727 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 857 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Val368Phe Rv2477c_p.Val368Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 6 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Val384Leu Rv2477c_p.Val384Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Val389_Asp390insGly Rv2477c_p.Val389_Asp390insGly 2 inframe_insertion (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1790 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 883 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Val389Ala Rv2477c_p.Val389Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Val405Gly Rv2477c_p.Val405Gly 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 2 3998 18533 0.000999500249875062 0.000272395196018755 0.00255712257980299 0.999892096034529 0.999610268708724 0.999986932062044 0.666666666666666 0.222778095503512 0.956728131707258 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1760 1798 False False 9.27113556778389 1.3280388413788 102.537019047163 0 0 0.000922255664717455 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Val406Phe Rv2477c_p.Val406Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1751 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Val420Ala Rv2477c_p.Val420Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Val426Met Rv2477c_p.Val426Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 7.01683899052165 1 732.5 1798 False False 0 0 7.01683899052165 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 6 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Val493Met Rv2477c_p.Val493Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 180.110710654533 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Val550fs Rv2477c_p.Val550fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1767 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Val70Ala Rv2477c_p.Val70Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1763 1798 False False 0 0 7.01683899052165 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 872 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 4 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Val70Met Rv2477c_p.Val70Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Val85Ile Rv2477c_p.Val85Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 15 1 14 13 40 3989 18495 0.00324837581209395 0.00173072204819086 0.00554841571637511 0.997841920690585 0.997062455780841 0.998457802661391 0.245283018867924 0.137551175552316 0.382824658226873 0.0666666666666666 0.0016864302413527 0.319484566578303 0.024390243902439 0.000617316893286519 0.128554020384146 0.331178598288149 0.00783379701686616 2.17800947768916 0.495022698361805 122 1798 False False 1.50686262221108 0.738738549114813 2.87916662331473 0.00025062656641604 6.34529515281273e-06 0.00139560213365507 0.997841920690585 0.997062455780841 0.998457802661391 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 1 3 11 5 1731 6635 0.00631458094144661 0.00315630578799124 0.0112703796091745 0.999246987951807 0.99824360331506 0.999755455269461 0.6875 0.413379363548641 0.889830045282882 0.25 0.00630946320970987 0.805879550316756 0.166666666666666 0.00421074451448947 0.641234578997674 1.27768149431927 0.0243240724613922 15.9215643925907 1 345 886 False False 0 0 0 0 0 0 0 8.43269786250722 2.69561894641379 30.9867788570277 0.000577367205542725 1.46175652087093e-05 0.00321264187487411 0.999246987951807 0.99824360331506 0.999755455269461 84 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2477c p.Val89Met Rv2477c_p.Val89Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 180.16529327284 1 732.5 1798 False False 4.63234191452137 0.0589984289392935 362.546724531758 0 0 0.000921564464586207 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c c.1018C>T Rv2752c_c.1018C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1026C>G Rv2752c_c.1026C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1029C>G Rv2752c_c.1029C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 4.63234191452137 0.0589984289392935 362.546724531758 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1050A>C Rv2752c_c.1050A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1050A>T Rv2752c_c.1050A>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.105A>G Rv2752c_c.105A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1063C>T Rv2752c_c.1063C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 5 33 3997 18502 0.00124937531234382 0.000405789275012681 0.0029131967931525 0.998219584569732 0.997500535018014 0.9987741368015 0.131578947368421 0.0441374400579144 0.280863845883753 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.701359352847969 0.213632422431239 1.80937351702697 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.22785363871091 NA NA NA NA NA NA 39 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1068C>T Rv2752c_c.1068C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1074C>T Rv2752c_c.1074C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 9 4000 18526 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 0.999514432155381 0.999078442003892 0.999777944189974 0.181818181818181 0.0228311982999596 0.517755852360172 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.02922222222222 0.108163524664371 4.97516458757911 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1107G>A Rv2752c_c.1107G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1122C>G Rv2752c_c.1122C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1134C>T Rv2752c_c.1134C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 16 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1137T>C Rv2752c_c.1137T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 9 4000 18526 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 0.999514432155381 0.999078442003892 0.999777944189974 0.181818181818181 0.0228311982999596 0.517755852360172 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.02922222222222 0.108163524664371 4.97516458757911 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1141C>T Rv2752c_c.1141C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1155C>T Rv2752c_c.1155C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1158C>T Rv2752c_c.1158C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1167G>A Rv2752c_c.1167G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 11 4002 18524 0 0 0.000921334294721226 0.99940652818991 0.998938363693644 0.999703704968061 0 0 0.284914152918154 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.84512569595635 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 20.3050873563561 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1167G>T Rv2752c_c.1167G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1221C>T Rv2752c_c.1221C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1225C>T Rv2752c_c.1225C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1239C>T Rv2752c_c.1239C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1248G>A Rv2752c_c.1248G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1275C>T Rv2752c_c.1275C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1278T>C Rv2752c_c.1278T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1290C>T Rv2752c_c.1290C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1311T>C Rv2752c_c.1311T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1314C>T Rv2752c_c.1314C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1317C>A Rv2752c_c.1317C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1317C>G Rv2752c_c.1317C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 5 4001 18530 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999730240086323 0.999370583585258 0.99991240407437 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.926268432891777 0.0195789744788398 8.28271147593069 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.22785363871091 NA NA NA NA NA NA 20 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1320T>C Rv2752c_c.1320T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.135C>T Rv2752c_c.135C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1368C>T Rv2752c_c.1368C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1380C>T Rv2752c_c.1380C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1383C>A Rv2752c_c.1383C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1419C>A Rv2752c_c.1419C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1438A>C Rv2752c_c.1438A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1452C>T Rv2752c_c.1452C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1467G>A Rv2752c_c.1467G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1467G>T Rv2752c_c.1467G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 20.3050873563561 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1470A>G Rv2752c_c.1470A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 11.2104345733627 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1473T>C Rv2752c_c.1473T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1485G>A Rv2752c_c.1485G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1503C>T Rv2752c_c.1503C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 4002 18530 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.05471226039473 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1509G>A Rv2752c_c.1509G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1509G>T Rv2752c_c.1509G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 11.2104345733627 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1521C>T Rv2752c_c.1521C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1527C>T Rv2752c_c.1527C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1539A>C Rv2752c_c.1539A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1560C>T Rv2752c_c.1560C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 41 950 3961 17585 0.0102448775612193 0.00736165147725983 0.0138729134108269 0.948745616401402 0.945472914181344 0.951876610152618 0.0413723511604439 0.0298502757430964 0.055710119688824 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.191601004531019 0.13634481518171 0.262522881685782 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 18 421 1724 6219 0.010332950631458 0.0061351352530145 0.0162815242907784 0.936596385542168 0.930465515481512 0.942340281846848 0.041002277904328 0.0244785795447496 0.0640288141745222 NA NA NA NA NA NA NA NA NA NA NA NA False True 1 1 1 0 0 0 0 0.154231720960479 0.0902798719005323 0.247726041411623 NA NA NA NA NA NA 1559 5) Not assoc w R Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1596G>A Rv2752c_c.1596G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 11.2104345733627 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.22785363871091 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1599G>A Rv2752c_c.1599G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1602C>T Rv2752c_c.1602C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1608G>T Rv2752c_c.1608G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1614C>T Rv2752c_c.1614C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.162G>A Rv2752c_c.162G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1638C>T Rv2752c_c.1638C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 4.63234191452137 0.0589984289392935 362.546724531758 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1662G>T Rv2752c_c.1662G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.1676A>G Rv2752c_c.1676A>G 2 stop_retained_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.-17C>G Rv2752c_c.-17C>G 2 upstream_gene_variant 3066208 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c c.183G>A Rv2752c_c.183G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 8 4002 18527 0 0 0.000921334294721226 0.999568384138117 0.999149722782159 0.999813641077243 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.7132714326819 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 5 1742 6635 0 0 0.00211537106925253 0.999246987951807 0.99824360331506 0.999755455269461 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.16029237021718 NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.189C>T Rv2752c_c.189C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.201C>T Rv2752c_c.201C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.207C>T Rv2752c_c.207C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.229C>T Rv2752c_c.229C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.234G>A Rv2752c_c.234G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 13 4000 18522 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 0.99929862422444 0.998800924705247 0.999626495767062 0.133333333333333 0.0165759134400836 0.404602696603372 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.712384615384615 0.0780187907102555 3.14836469457445 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 11 1741 6629 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.998343373493976 0.997037775344334 0.999172737054126 0.0833333333333333 0.00210759323186022 0.384796165150944 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.34614380450107 0.0080407298813373 2.38478511505618 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.240C>T Rv2752c_c.240C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.258C>T Rv2752c_c.258C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.-26A>G Rv2752c_c.-26A>G 2 upstream_gene_variant 3066217 NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1488 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c c.306C>G Rv2752c_c.306C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.-30T>C Rv2752c_c.-30T>C 2 upstream_gene_variant 3066221 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1427 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c c.312C>T Rv2752c_c.312C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 4.63234191452137 0.0589984289392935 362.546724531758 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.-31A>G Rv2752c_c.-31A>G 2 upstream_gene_variant 3066222 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c c.330T>G Rv2752c_c.330T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.-34G>C Rv2752c_c.-34G>C 2 upstream_gene_variant 3066225 1 0 0 0 2 1 4000 18534 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 0.999946048017264 0.999699435860871 0.999998634054993 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 1425 1798 False False 9.267 0.482236652039982 544.73752523911 0 0 0.000921794749483055 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 1 1740 6639 0.00114810562571756 0.000139071172424607 0.00414113746933503 0.999849397590361 0.999161185884076 0.99999618708438 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 701 886 False False 0 0 0 0 0 0 0 7.63103448275862 0.396930405600961 448.930838944076 0 0 0.00211779995375925 0.999849397590361 0.999161185884076 0.99999618708438 16 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c c.360C>T Rv2752c_c.360C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 4002 18529 0 0 0.000921334294721226 0.999676288103587 0.999295549654279 0.999881194471086 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.93385874811763 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 1742 6636 0 0 0.00211537106925253 0.999397590361445 0.998458316867766 0.999835840034063 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 5.77543554850383 NA NA NA NA NA NA 11 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.366A>C Rv2752c_c.366A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.378C>A Rv2752c_c.378C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 4000 18535 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 1 0.999800997443015 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.869940791113183 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.-38T>G Rv2752c_c.-38T>G 2 upstream_gene_variant 3066229 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c c.-39_-32delCTTCGGTG Rv2752c_c.-39_-32delCTTCGGTG 2 upstream_gene_variant 3066222 1 2 1 1 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 4.63234191452137 0.0589984289392935 362.546724531758 0.323623032303333 101.5 1798 False False 4.63234191452137 0.0589984289392935 362.546724531758 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 1741 6639 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999849397590361 0.999161185884076 0.99999618708438 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 3.81332567489948 0.0485516368820753 298.645085154332 0.372480464000747 70 886 False False 0 0 0 0 0 0 0 3.81332567489948 0.0485516368820753 298.645085154332 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c c.-3G>T Rv2752c_c.-3G>T 2 upstream_gene_variant 3066194 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c c.450T>G Rv2752c_c.450T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.-46C>T Rv2752c_c.-46C>T 2 upstream_gene_variant 3066237 1 0 0 0 4 2 3998 18533 0.000999500249875062 0.000272395196018755 0.00255712257980299 0.999892096034529 0.999610268708724 0.999986932062044 0.666666666666666 0.222778095503512 0.956728131707258 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1484 1798 False False 9.27113556778389 1.3280388413788 102.537019047163 0 0 0.000922255664717455 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 4 2 1738 6638 0.00229621125143513 0.000625983621299944 0.00586868734668228 0.999698795180722 0.998912372612698 0.9999635206173 0.666666666666666 0.222778095503512 0.956728131707258 NA NA NA 0 0 0.841886116991581 NA NA NA NA 732 886 False False 0 0 0 0 0 0 0 7.63866513233601 1.09334902605852 84.6681831076215 0 0 0.00212023442240146 0.999698795180722 0.998912372612698 0.9999635206173 7 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c c.477T>C Rv2752c_c.477T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 16 4001 18519 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999136768276234 0.998598543286194 0.999506510531465 0.0588235294117647 0.00148817439126663 0.28688939666722 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.28928705323669 0.00690014745187587 1.86323046421039 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 10 1741 6630 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.998493975903614 0.99723211779991 0.999277574112589 0.0909090909090909 0.00229897221381426 0.412779916988382 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.380815623205054 0.00877354449888318 2.68034297189656 NA NA NA NA NA NA 24 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.-47C>T Rv2752c_c.-47C>T 2 upstream_gene_variant 3066238 1 0 0 0 4 2 3998 18533 0.000999500249875062 0.000272395196018755 0.00255712257980299 0.999892096034529 0.999610268708724 0.999986932062044 0.666666666666666 0.222778095503512 0.956728131707258 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1551 1798 False False 9.27113556778389 1.3280388413788 102.537019047163 0 0 0.000922255664717455 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 4 2 1738 6638 0.00229621125143513 0.000625983621299944 0.00586868734668228 0.999698795180722 0.998912372612698 0.9999635206173 0.666666666666666 0.222778095503512 0.956728131707258 NA NA NA 0 0 0.841886116991581 NA NA NA NA 764 886 False False 0 0 0 0 0 0 0 7.63866513233601 1.09334902605852 84.6681831076215 0 0 0.00212023442240146 0.999698795180722 0.998912372612698 0.9999635206173 7 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c c.480C>T Rv2752c_c.480C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.496C>T Rv2752c_c.496C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.537C>T Rv2752c_c.537C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.549C>T Rv2752c_c.549C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.576C>G Rv2752c_c.576C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.576C>T Rv2752c_c.576C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 6 17 3996 18518 0.00149925037481259 0.000550390926465245 0.00326035944931569 0.999082816293498 0.998531904853251 0.9994656187862 0.260869565217391 0.102286133915358 0.484051970402438 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.63557675322381 0.52766413609113 4.35101081538833 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 6 1 1736 6639 0.00344431687715269 0.00126502019745104 0.00748164597286304 0.999849397590361 0.999161185884076 0.99999618708438 0.857142857142857 0.421276802956804 0.996389703138099 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 22.9458525345622 2.77982437027815 1049.59655105486 NA NA NA NA NA NA 45 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.585C>T Rv2752c_c.585C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.598C>T Rv2752c_c.598C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01683899052165 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.-5C>G Rv2752c_c.-5C>G 2 upstream_gene_variant 3066196 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c c.603C>T Rv2752c_c.603C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 7.01683899052165 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.606C>T Rv2752c_c.606C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.633C>A Rv2752c_c.633C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.639A>G Rv2752c_c.639A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.66C>T Rv2752c_c.66C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.675C>T Rv2752c_c.675C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 25 129 3977 18406 0.00624687656171914 0.00404660854809457 0.00920789946868461 0.993040194227138 0.991735738767744 0.994186138020498 0.162337662337662 0.107896973756947 0.230246007338007 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.89692086084131 0.558973814356565 1.38658242975402 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf NA NA NA NA NA NA 46 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.690C>T Rv2752c_c.690C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.699G>A Rv2752c_c.699G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.708G>A Rv2752c_c.708G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.711T>C Rv2752c_c.711T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.717C>G Rv2752c_c.717C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.720C>T Rv2752c_c.720C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.732G>A Rv2752c_c.732G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.756A>C Rv2752c_c.756A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.771G>A Rv2752c_c.771G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.786C>T Rv2752c_c.786C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.795G>T Rv2752c_c.795G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 11.2104345733627 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.804C>T Rv2752c_c.804C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.819A>G Rv2752c_c.819A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 4002 18529 0 0 0.000921334294721226 0.999676288103587 0.999295549654279 0.999881194471086 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.93385874811763 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 9.22785363871091 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.835C>T Rv2752c_c.835C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.843G>A Rv2752c_c.843G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.846T>G Rv2752c_c.846T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.858C>T Rv2752c_c.858C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.118754661339467 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.861C>T Rv2752c_c.861C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.891C>G Rv2752c_c.891C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.-8delG Rv2752c_c.-8delG 2 upstream_gene_variant 3066198 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c c.918C>A Rv2752c_c.918C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.-937A>T Rv2752c_c.-937A>T 2 upstream_gene_variant 3067128 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c c.942G>A Rv2752c_c.942G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.-944C>T Rv2752c_c.-944C>T 2 upstream_gene_variant 3067135 1 1 0 1 3 15 3999 18520 0.000749625187406296 0.000154617422592445 0.00218914487959466 0.999190720258969 0.998665566860464 0.999546983769752 0.166666666666666 0.0357850831215746 0.414177491394774 0 0 0.975 0 0 0.218019360910534 0 0 180.119376132067 1 732.5 1798 False False 0.926231557889472 0.171789322594681 3.27612057704897 0 0 0.000922025149498025 0.999190720258969 0.998665566860464 0.999546983769752 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 12 1742 6628 0 0 0.00211537106925253 0.998192771084337 0.996845265024717 0.999065840721332 0 0 0.264648469397051 0 0 0.975 0 0 0.264648469397051 0 0 148.069401249663 1 345 886 False False 0 0 0 0 0 0 0 0 0 1.37098656231317 0 0 0.00211537106925253 0.998192771084337 0.996845265024717 0.999065840721332 40 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c c.-945A>G Rv2752c_c.-945A>G 2 upstream_gene_variant 3067136 1 1 0 1 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 180.110710654533 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c c.-951delC Rv2752c_c.-951delC 2 upstream_gene_variant 3067141 1 9 0 9 1 11 4001 18524 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.99940652818991 0.998938363693644 0.999703704968061 0.0833333333333333 0.00210759323186022 0.384796165150944 0 0 0.336267116879942 0 0 0.284914152918154 0 0 2.34670290752394 0.376502746586677 115.5 1798 False False 0.420894776305923 0.00977937778460056 2.89742168554269 0 0 0.000921564464586207 0.99940652818991 0.998938363693644 0.999703704968061 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 6 1742 6634 0 0 0.00211537106925253 0.999096385542168 0.998034257105878 0.999668319522948 0 0 0.4592581264399 0 0 0.602364635616474 0 0 0.4592581264399 0 0 5.7736953742088 0.586611391802338 74 886 False False 0 0 0 0 0 0 0 0 0 3.23733664541029 0 0 0.00211537106925253 0.999096385542168 0.998034257105878 0.999668319522948 10 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c c.-960A>G Rv2752c_c.-960A>G 2 upstream_gene_variant 3067151 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c c.966G>A Rv2752c_c.966G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 24.6627854419351 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA 17 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.-966G>T Rv2752c_c.-966G>T 2 upstream_gene_variant 3067157 1 10 0 10 0 10 4002 18525 0 0 0.000921334294721226 0.999460480172646 0.999008028394192 0.999741249920483 0 0 0.30849710781876 0 0 0.30849710781876 0 0 0.30849710781876 0 0 2.06609723386524 0.22623165660618 91 1798 False False 0 0 2.06609723386524 0 0 0.000921334294721226 0.999460480172646 0.999008028394192 0.999741249920483 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 0 8 1742 6632 0 0 0.00211537106925253 0.998795180722891 0.997627413333175 0.999479705585957 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 2.23276380149116 0.218600017308822 42 886 False False 0 0 0 0 0 0 0 0 0 2.23276380149116 0 0 0.00211537106925253 0.998795180722891 0.997627413333175 0.999479705585957 17 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c c.978C>T Rv2752c_c.978C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 180.120401159035 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 148.314534587063 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Moxifloxacin Rv2752c c.-981A>G Rv2752c_c.-981A>G 2 upstream_gene_variant 3067172 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c deletion Rv2752c_deletion 2 feature_ablation (see "Genomic_coordinates" sheet) NA 0 0 0 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1552 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 765 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c LoF Rv2752c_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 138 5 133 93 203 3909 18332 0.0232383808095952 0.0187963588165245 0.02839384558412 0.98904774750472 0.987443203944765 0.990495959200269 0.314189189189189 0.261715779275698 0.370428902386151 0.036231884057971 0.0118672422579183 0.0825263318810427 0.0240384615384615 0.00785026234702143 0.0552032318069257 0.176304152553294 0.0562903168656414 0.422275029511827 8.57700854076589e-07 14 1798 True False 2.14847887973566 1.65823713750315 2.76653218648831 0.00127746550843127 0.000414915566639985 0.0029786395304794 0.98904774750472 0.987443203944765 0.990495959200269 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 63 3 60 34 77 1708 6563 0.0195177956371986 0.0135535738415647 0.0271681688076995 0.988403614457831 0.98552754107997 0.990837776834967 0.306306306306306 0.222326718620402 0.400926027779206 0.0476190476190476 0.00992995115073328 0.13291840074815 0.0375 0.00780118726571669 0.105701985016508 0.192125292740046 0.0384979887835941 0.590258753652841 0.000794321614370379 11 886 False False 0 0 0 0 0 0 0 1.69669089692508 1.09441078128275 2.58149679530864 0.00175336060783167 0.00036173117021743 0.00511543424834153 0.988403614457831 0.98552754107997 0.990837776834967 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ala110fs Rv2752c_p.Ala110fs 2 frameshift (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 4002 18529 0 0 0.000921334294721226 0.999676288103587 0.999295549654279 0.999881194471086 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.93385874811763 0.599069212767884 166.5 1798 False False 0 0 3.93385874811763 0 0 0.000921334294721226 0.999676288103587 0.999295549654279 0.999881194471086 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ala110Ser Rv2752c_p.Ala110Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1464 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 720 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ala155Val Rv2752c_p.Ala155Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ala157_Thr160del Rv2752c_p.Ala157_Thr160del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ala157Thr Rv2752c_p.Ala157Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ala206Thr Rv2752c_p.Ala206Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ala206Val Rv2752c_p.Ala206Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ala20Glu Rv2752c_p.Ala20Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ala20Pro Rv2752c_p.Ala20Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ala20Val Rv2752c_p.Ala20Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ala229fs Rv2752c_p.Ala229fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1553 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 766 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ala236Val Rv2752c_p.Ala236Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ala254dup Rv2752c_p.Ala254dup 2 inframe_insertion (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 3999 18535 0.000749625187406296 0.000154617422592445 0.00218914487959466 1 0.999800997443015 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1414 1798 False False Inf 1.91440039171731 Inf 0 0 0.000922025149498025 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 1740 6640 0.00114810562571756 0.000139071172424607 0.00414113746933503 1 0.999444600156968 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 693 886 False False 0 0 0 0 0 0 0 Inf 0.716065670156237 Inf 0 0 0.00211779995375925 1 0.999444600156968 1 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ala254Val Rv2752c_p.Ala254Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1456 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 715 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 3 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ala273Thr Rv2752c_p.Ala273Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 1 5 4001 18530 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999730240086323 0.999370583585258 0.99991240407437 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.521823750104981 0 0 0.521823750104981 0 0 5.05597597896217 0.593765431957714 148 1798 False False 0.926268432891777 0.0195789744788398 8.28271147593069 0 0 0.000921564464586207 0.999730240086323 0.999370583585258 0.99991240407437 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 1 5 1741 6635 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999246987951807 0.99824360331506 0.999755455269461 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.16268347134163 0.590656717325847 87 886 False False 0 0 0 0 0 0 0 0.76220562894888 0.016109698917676 6.81778471156948 0 0 0.00211658481469046 0.999246987951807 0.99824360331506 0.999755455269461 3 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ala290fs Rv2752c_p.Ala290fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ala290Pro Rv2752c_p.Ala290Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ala292Asp Rv2752c_p.Ala292Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1428 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ala292Val Rv2752c_p.Ala292Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ala296Val Rv2752c_p.Ala296Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 50 0 50 1 62 4001 18473 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.996654977070407 0.995713854744703 0.997434457524223 0.0158730158730158 0.000401789229084887 0.085295709299263 0 0 0.0711217364641976 0 0 0.0577626344292909 0 0 0.353721181113309 0.000110517946934254 21 1798 True False 0.0744692859043303 0.00185938155269042 0.430816493314416 0 0 0.000921564464586207 0.996654977070407 0.995713854744703 0.997434457524223 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 22 0 22 0 26 1742 6614 0 0 0.00211537106925253 0.996084337349397 0.994267874481466 0.997440613016852 0 0 0.132274604497754 0 0 0.154372512815574 0 0 0.132274604497754 0 0 0.694034760347418 0.0080692190520072 17 886 False False 0 0 0 0 0 0 0 0 0 0.579568157474618 0 0 0.00211537106925253 0.996084337349397 0.994267874481466 0.997440613016852 114 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ala330fs Rv2752c_p.Ala330fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 2 4 4000 18531 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 0.999784192069058 0.999447539013843 0.999941196572055 0.333333333333333 0.0432718682927417 0.777221904496487 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1532 1798 False False 2.316375 0.209452463855679 16.1672355802828 0 0 0.000921794749483055 0.999784192069058 0.999447539013843 0.999941196572055 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ala368fs Rv2752c_p.Ala368fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 3999 18535 0.000749625187406296 0.000154617422592445 0.00218914487959466 1 0.999800997443015 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1457 1798 False False Inf 1.91440039171731 Inf 0 0 0.000922025149498025 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 716 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ala376Gly Rv2752c_p.Ala376Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 1 8 4001 18527 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999568384138117 0.999149722782159 0.999813641077243 0.111111111111111 0.00280913674659921 0.482496514917337 0 0 0.4592581264399 0 0 0.369416647552819 0 0 3.93441760632448 0.599065478106383 161.5 1798 False False 0.578824043989002 0.0130447733848513 4.31945136015563 0 0 0.000921564464586207 0.999568384138117 0.999149722782159 0.999813641077243 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.302036906212 1 345 886 False False 0 0 0 0 0 0 0 0 0 9.22785363871091 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 6 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ala378Thr Rv2752c_p.Ala378Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ala378Val Rv2752c_p.Ala378Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 0 8 4002 18527 0 0 0.000921334294721226 0.999568384138117 0.999149722782159 0.999813641077243 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 2.7132714326819 0.365167222786382 108.5 1798 False False 0 0 2.7132714326819 0 0 0.000921334294721226 0.999568384138117 0.999149722782159 0.999813641077243 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ala405fs Rv2752c_p.Ala405fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ala405Thr Rv2752c_p.Ala405Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ala423fs Rv2752c_p.Ala423fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ala433Ser Rv2752c_p.Ala433Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1435 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 705 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ala436Asp Rv2752c_p.Ala436Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ala441Ser Rv2752c_p.Ala441Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ala454fs Rv2752c_p.Ala454fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1419 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 697 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ala474Thr Rv2752c_p.Ala474Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ala474Val Rv2752c_p.Ala474Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 5 4001 18530 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999730240086323 0.999370583585258 0.99991240407437 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.975 0 0 0.521823750104981 0 0 180.126521603627 1 198.5 1798 False False 0.926268432891777 0.0195789744788398 8.28271147593069 0 0 0.000921564464586207 0.999730240086323 0.999370583585258 0.99991240407437 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ala489Val Rv2752c_p.Ala489Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ala503Gly Rv2752c_p.Ala503Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ala521Pro Rv2752c_p.Ala521Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ala521Thr Rv2752c_p.Ala521Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1436 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ala530fs Rv2752c_p.Ala530fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ala530Thr Rv2752c_p.Ala530Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ala89Glu Rv2752c_p.Ala89Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 180.110710654533 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ala89Val Rv2752c_p.Ala89Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1449 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Arg120His Rv2752c_p.Arg120His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1437 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 706 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Arg17Gly Rv2752c_p.Arg17Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Arg17Pro Rv2752c_p.Arg17Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Arg227Gly Rv2752c_p.Arg227Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 7.01683899052165 1 732.5 1798 False False 0 0 7.01683899052165 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.22785363871091 1 345 886 False False 0 0 0 0 0 0 0 0 0 9.22785363871091 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Arg232Gln Rv2752c_p.Arg232Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1533 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Arg244His Rv2752c_p.Arg244His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Arg244Trp Rv2752c_p.Arg244Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Arg257Trp Rv2752c_p.Arg257Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 180.16529327284 1 732.5 1798 False False 4.63234191452137 0.0589984289392935 362.546724531758 0 0 0.000921564464586207 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Arg258Gln Rv2752c_p.Arg258Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1500 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 738 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Arg258Leu Rv2752c_p.Arg258Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 9 0 9 1 11 4001 18524 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.99940652818991 0.998938363693644 0.999703704968061 0.0833333333333333 0.00210759323186022 0.384796165150944 0 0 0.336267116879942 0 0 0.284914152918154 0 0 2.34670290752394 0.376502746586677 115.5 1798 False False 0.420894776305923 0.00977937778460056 2.89742168554269 0 0 0.000921564464586207 0.99940652818991 0.998938363693644 0.999703704968061 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 8 1742 6632 0 0 0.00211537106925253 0.998795180722891 0.997627413333175 0.999479705585957 0 0 0.369416647552819 0 0 0.4592581264399 0 0 0.369416647552819 0 0 3.23635995254571 0.355640009447065 57 886 False False 0 0 0 0 0 0 0 0 0 2.23276380149116 0 0 0.00211537106925253 0.998795180722891 0.997627413333175 0.999479705585957 13 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Arg258* Rv2752c_p.Arg258* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Arg264Leu Rv2752c_p.Arg264Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1525 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Arg268Cys Rv2752c_p.Arg268Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Arg280* Rv2752c_p.Arg280* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Arg317Pro Rv2752c_p.Arg317Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Arg320_Gly321insMetSerArg Rv2752c_p.Arg320_Gly321insMetSerArg 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1526 1798 False False 4.63234191452137 0.0589984289392935 362.546724531758 0 0 0.000921564464586207 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 750 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Arg320His Rv2752c_p.Arg320His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Arg320Leu Rv2752c_p.Arg320Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 180.110710654533 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 148.292249815985 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Arg361Gly Rv2752c_p.Arg361Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 16 0 16 1 18 4001 18517 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999028864310763 0.998465619515959 0.999424345094191 0.0526315789473684 0.00133162880417942 0.260280654195214 0 0 0.205907214207822 0 0 0.185301968137852 0 0 1.20068725725972 0.0934571807576908 47 1798 False False 0.257116276486433 0.00617306717925458 1.62945795675324 0 0 0.000921564464586207 0.999028864310763 0.998465619515959 0.999424345094191 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 17 0 17 1 18 1741 6622 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.997289156626506 0.995719069710777 0.998392615571978 0.0526315789473684 0.00133162880417942 0.260280654195214 0 0 0.195064322969093 0 0 0.185301968137852 0 0 0.922907023086195 0.0326865392367595 20 886 False False 0 0 0 0 0 0 0 0.211308953985576 0.00507243831516013 1.34033100506227 0 0 0.00211658481469046 0.997289156626506 0.995719069710777 0.998392615571978 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Arg361Ser Rv2752c_p.Arg361Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Arg389Trp Rv2752c_p.Arg389Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1511 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Arg391fs Rv2752c_p.Arg391fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 3999 18535 0.000749625187406296 0.000154617422592445 0.00218914487959466 1 0.999800997443015 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1489 1798 False False Inf 1.91440039171731 Inf 0 0 0.000922025149498025 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Arg391Ser Rv2752c_p.Arg391Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Arg39* Rv2752c_p.Arg39* 2 stop_gained (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 4002 18530 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 5.05471226039473 0.593754047365944 137.5 1798 False False 0 0 5.05471226039473 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 1742 6636 0 0 0.00211537106925253 0.999397590361445 0.998458316867766 0.999835840034063 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.77543554850383 0.5866324014095 78.5 886 False False 0 0 0 0 0 0 0 0 0 5.77543554850383 0 0 0.00211537106925253 0.999397590361445 0.998458316867766 0.999835840034063 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Arg404Ser Rv2752c_p.Arg404Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Arg465Gln Rv2752c_p.Arg465Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Arg465Trp Rv2752c_p.Arg465Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 2 6 4000 18529 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 0.999676288103587 0.999295549654279 0.999881194471086 0.25 0.0318540262499442 0.650855794412824 0 0 0.602364635616474 0 0 0.4592581264399 0 0 7.01959065625856 1 732.5 1798 False False 1.54408333333333 0.15233241265383 8.63930225227516 0 0 0.000921794749483055 0.999676288103587 0.999295549654279 0.999881194471086 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 1740 6639 0.00114810562571756 0.000139071172424607 0.00414113746933503 0.999849397590361 0.999161185884076 0.99999618708438 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 148.48461554588 1 345 886 False False 0 0 0 0 0 0 0 7.63103448275862 0.396930405600961 448.930838944076 0 0 0.00211779995375925 0.999849397590361 0.999161185884076 0.99999618708438 6 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Arg495dup Rv2752c_p.Arg495dup 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1415 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Arg528Gln Rv2752c_p.Arg528Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1409 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Arg535Cys Rv2752c_p.Arg535Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 8 4001 18527 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999568384138117 0.999149722782159 0.999813641077243 0.111111111111111 0.00280913674659921 0.482496514917337 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1518 1798 False False 0.578824043989002 0.0130447733848513 4.31945136015563 0 0 0.000921564464586207 0.999568384138117 0.999149722782159 0.999813641077243 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 7 1741 6633 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.99894578313253 0.997829124235982 0.999576048424705 0.125 0.0031597235312519 0.526509670875206 NA NA NA 0 0 0.409616397225003 NA NA NA NA 745 886 False False 0 0 0 0 0 0 0 0.544268482809551 0.0120730252704479 4.24125119298071 0 0 0.00211658481469046 0.99894578313253 0.997829124235982 0.999576048424705 11 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Arg547Cys Rv2752c_p.Arg547Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1421 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Arg547His Rv2752c_p.Arg547His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1441 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 708 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Arg65Ser Rv2752c_p.Arg65Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Arg97fs Rv2752c_p.Arg97fs 2 frameshift (see "Genomic_coordinates" sheet) 1 3 0 3 0 7 4002 18528 0 0 0.000921334294721226 0.999622336120852 0.999222023868969 0.999848146482689 0 0 0.409616397225003 0 0 0.707598226178713 0 0 0.409616397225003 0 0 11.2080160590427 1 732.5 1798 False False 0 0 3.21342445526953 0 0 0.000921334294721226 0.999622336120852 0.999222023868969 0.999848146482689 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 5 1742 6635 0 0 0.00211537106925253 0.999246987951807 0.99824360331506 0.999755455269461 0 0 0.521823750104981 0 0 0.975 0 0 0.521823750104981 0 0 148.225395409418 1 98.5 886 False False 0 0 0 0 0 0 0 0 0 4.16029237021718 0 0 0.00211537106925253 0.999246987951807 0.99824360331506 0.999755455269461 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Arg97* Rv2752c_p.Arg97* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 3 2 3999 18533 0.000749625187406296 0.000154617422592445 0.00218914487959466 0.999892096034529 0.999610268708724 0.999986932062044 0.6 0.146632799634673 0.947255049473683 0 0 0.975 0 0 0.841886116991581 0 0 180.245446932505 1 732.5 1798 False False 6.9516129032258 0.795983567419885 83.4550561301111 0 0 0.000922025149498025 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 1 1740 6639 0.00114810562571756 0.000139071172424607 0.00414113746933503 0.999849397590361 0.999161185884076 0.99999618708438 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 729 886 False False 0 0 0 0 0 0 0 7.63103448275862 0.396930405600961 448.930838944076 0 0 0.00211779995375925 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Asn30Asp Rv2752c_p.Asn30Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1478 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 730 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 3 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Asn30His Rv2752c_p.Asn30His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1410 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Asn30Lys Rv2752c_p.Asn30Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 9 4002 18526 0 0 0.000921334294721226 0.999514432155381 0.999078442003892 0.999777944189974 0 0 0.336267116879942 0 0 0.4592581264399 0 0 0.336267116879942 0 0 3.93322186265644 0.599073464296973 171 1798 False False 0 0 2.34636960420997 0 0 0.000921334294721226 0.999514432155381 0.999078442003892 0.999777944189974 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 6 1742 6634 0 0 0.00211537106925253 0.999096385542168 0.998034257105878 0.999668319522948 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 4.15966552310285 0.59066833166921 93.5 886 False False 0 0 0 0 0 0 0 0 0 3.23733664541029 0 0 0.00211537106925253 0.999096385542168 0.998034257105878 0.999668319522948 5 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Asn30Ser Rv2752c_p.Asn30Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 6 4002 18529 0 0 0.000921334294721226 0.999676288103587 0.999295549654279 0.999881194471086 0 0 0.4592581264399 0 0 0.841886116991581 0 0 0.4592581264399 0 0 24.6574657129635 1 732.5 1798 False False 0 0 3.93385874811763 0 0 0.000921334294721226 0.999676288103587 0.999295549654279 0.999881194471086 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1742 6636 0 0 0.00211537106925253 0.999397590361445 0.998458316867766 0.999835840034063 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 724 886 False False 0 0 0 0 0 0 0 0 0 5.77543554850383 0 0 0.00211537106925253 0.999397590361445 0.998458316867766 0.999835840034063 16 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Asn30Tyr Rv2752c_p.Asn30Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.118754661339467 Inf 0.177574655011758 72.5 1798 False False Inf 0.118754661339467 Inf 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Asn344fs Rv2752c_p.Asn344fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1402 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Asn392fs Rv2752c_p.Asn392fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1507 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Asn406Lys Rv2752c_p.Asn406Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Asn406Ser Rv2752c_p.Asn406Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 24.6614555089698 1 732.5 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 148.292249815985 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Asn522fs Rv2752c_p.Asn522fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Asp152Ala Rv2752c_p.Asp152Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 4002 18530 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 5.05471226039473 0.593754047365944 137.5 1798 False False 0 0 5.05471226039473 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Asp152fs Rv2752c_p.Asp152fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Asp170_Gly195del Rv2752c_p.Asp170_Gly195del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.118754661339467 Inf 0.177574655011758 72.5 1798 False False Inf 0.118754661339467 Inf 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Asp170Asn Rv2752c_p.Asp170Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 4002 18530 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 7.01646036669751 1 198.5 1798 False False 0 0 5.05471226039473 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 15 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Asp170Gly Rv2752c_p.Asp170Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1490 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Asp174fs Rv2752c_p.Asp174fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1403 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 687 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Asp174Glu Rv2752c_p.Asp174Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Asp179fs Rv2752c_p.Asp179fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Asp184Glu Rv2752c_p.Asp184Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Asp184Gly Rv2752c_p.Asp184Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Asp193Asn Rv2752c_p.Asp193Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Asp202Ala Rv2752c_p.Asp202Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1404 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 688 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 6 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Asp230Tyr Rv2752c_p.Asp230Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1465 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Asp243fs Rv2752c_p.Asp243fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Asp250Glu Rv2752c_p.Asp250Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Asp332fs Rv2752c_p.Asp332fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1450 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 713 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Asp332Gly Rv2752c_p.Asp332Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 3 1 3999 18534 0.000749625187406296 0.000154617422592445 0.00218914487959466 0.999946048017264 0.999699435860871 0.999998634054993 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 1519 1798 False False 13.9039759939985 1.11586102000443 726.694777866907 0 0 0.000922025149498025 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 1741 6639 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999849397590361 0.999161185884076 0.99999618708438 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 746 886 False False 0 0 0 0 0 0 0 3.81332567489948 0.0485516368820753 298.645085154332 0 0 0.00211658481469046 0.999849397590361 0.999161185884076 0.99999618708438 7 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Asp332Tyr Rv2752c_p.Asp332Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1512 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Asp430Ala Rv2752c_p.Asp430Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Asp44Ala Rv2752c_p.Asp44Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 1 4000 18534 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 0.999946048017264 0.999699435860871 0.999998634054993 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 1451 1798 False False 9.267 0.482236652039982 544.73752523911 0 0 0.000921794749483055 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Asp44Glu Rv2752c_p.Asp44Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1438 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 707 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Asp44Gly Rv2752c_p.Asp44Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1496 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 736 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Asp450Gly Rv2752c_p.Asp450Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 7 6 3995 18529 0.00174912543728135 0.000703519237747539 0.00360052552178143 0.999676288103587 0.999295549654279 0.999881194471086 0.538461538461538 0.251345482270303 0.807767558198712 0 0 0.521823750104981 0 0 0.4592581264399 0 0 5.06329834140149 0.593831696447146 154.5 1798 False False 5.41105548602419 1.55602663123592 19.4973834281957 0 0 0.000922947902467247 0.999676288103587 0.999295549654279 0.999881194471086 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 3 2 1739 6638 0.00172215843857634 0.000355291378803123 0.00502455256196275 0.999698795180722 0.998912372612698 0.9999635206173 0.6 0.146632799634673 0.947255049473683 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3400355540914 1 345 886 False False 0 0 0 0 0 0 0 5.72570442783208 0.655180308104634 68.6863687806226 0 0 0.00211901648886052 0.999698795180722 0.998912372612698 0.9999635206173 3 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Asp500fs Rv2752c_p.Asp500fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1554 1798 False False 4.63234191452137 0.0589984289392935 362.546724531758 0 0 0.000921564464586207 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 1741 6639 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999849397590361 0.999161185884076 0.99999618708438 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 767 886 False False 0 0 0 0 0 0 0 3.81332567489948 0.0485516368820753 298.645085154332 0 0 0.00211658481469046 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Asp63Ala Rv2752c_p.Asp63Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 1 4000 18534 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 0.999946048017264 0.999699435860871 0.999998634054993 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 1491 1798 False False 9.267 0.482236652039982 544.73752523911 0 0 0.000921794749483055 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 1740 6640 0.00114810562571756 0.000139071172424607 0.00414113746933503 1 0.999444600156968 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 734 886 False False 0 0 0 0 0 0 0 Inf 0.716065670156237 Inf 0 0 0.00211779995375925 1 0.999444600156968 1 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Asp63Gly Rv2752c_p.Asp63Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 24.6614555089698 1 732.5 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Asp72fs Rv2752c_p.Asp72fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1534 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Asp72Glu Rv2752c_p.Asp72Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 4000 18535 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 1 0.999800997443015 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1429 1798 False False Inf 0.869940791113183 Inf 0 0 0.000921794749483055 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 702 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Asp85Ala Rv2752c_p.Asp85Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Asp85fs Rv2752c_p.Asp85fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 3999 18535 0.000749625187406296 0.000154617422592445 0.00218914487959466 1 0.999800997443015 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1513 1798 False False Inf 1.91440039171731 Inf 0 0 0.000922025149498025 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 744 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Cys116Phe Rv2752c_p.Cys116Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1422 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Cys201fs Rv2752c_p.Cys201fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Cys201* Rv2752c_p.Cys201* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1430 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Cys237Arg Rv2752c_p.Cys237Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1470 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Cys45* Rv2752c_p.Cys45* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1471 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 722 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Cys45Tyr Rv2752c_p.Cys45Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1416 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 694 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gln132fs Rv2752c_p.Gln132fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1434 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gln132Pro Rv2752c_p.Gln132Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 1 5 4001 18530 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999730240086323 0.999370583585258 0.99991240407437 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.602364635616474 0 0 0.521823750104981 0 0 7.01821447943561 1 732.5 1798 False False 0.926268432891777 0.0195789744788398 8.28271147593069 0 0 0.000921564464586207 0.999730240086323 0.999370583585258 0.99991240407437 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 1741 6639 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999849397590361 0.999161185884076 0.99999618708438 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 148.399526333966 1 596 886 False False 0 0 0 0 0 0 0 3.81332567489948 0.0485516368820753 298.645085154332 0 0 0.00211658481469046 0.999849397590361 0.999161185884076 0.99999618708438 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gln132* Rv2752c_p.Gln132* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1395 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gln175fs Rv2752c_p.Gln175fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1514 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gln175His Rv2752c_p.Gln175His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1485 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gln175* Rv2752c_p.Gln175* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1396 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gln246Pro Rv2752c_p.Gln246Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gln246* Rv2752c_p.Gln246* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 3 2 3999 18533 0.000749625187406296 0.000154617422592445 0.00218914487959466 0.999892096034529 0.999610268708724 0.999986932062044 0.6 0.146632799634673 0.947255049473683 0 0 0.975 0 0 0.841886116991581 0 0 180.245446932505 1 732.5 1798 False False 6.9516129032258 0.795983567419885 83.4550561301111 0 0 0.000922025149498025 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 1741 6639 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999849397590361 0.999161185884076 0.99999618708438 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 148.399526333966 1 596 886 False False 0 0 0 0 0 0 0 3.81332567489948 0.0485516368820753 298.645085154332 0 0 0.00211658481469046 0.999849397590361 0.999161185884076 0.99999618708438 6 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gln247* Rv2752c_p.Gln247* 2 stop_gained (see "Genomic_coordinates" sheet) 1 24 0 24 25 45 3977 18490 0.00624687656171914 0.00404660854809457 0.00920789946868461 0.997572160776908 0.996752693755171 0.998228583042076 0.357142857142857 0.246122728103144 0.480666726347427 0 0 0.142473597722525 0 0 0.078705100406843 0 0 0.77287500478684 0.0145214008211066 31 1798 False False 2.58290727237169 1.51584263054564 4.30824759113734 0 0 0.000927123250390445 0.997572160776908 0.996752693755171 0.998228583042076 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 4 11 1738 6629 0.00229621125143513 0.000625983621299944 0.00586868734668228 0.998343373493976 0.997037775344334 0.999172737054126 0.266666666666666 0.0778715462910436 0.551003241036971 0 0 0.336267116879942 0 0 0.284914152918154 0 0 1.93455011418192 0.2189323427169 45 886 False False 0 0 0 0 0 0 0 1.38696516372005 0.321701406266706 4.68774708667186 0 0 0.00212023442240146 0.998343373493976 0.997037775344334 0.999172737054126 29 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gln275Arg Rv2752c_p.Gln275Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gln308His Rv2752c_p.Gln308His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1479 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gln308Pro Rv2752c_p.Gln308Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 4001 18533 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999892096034529 0.999610268708724 0.999986932062044 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6689469404428 1 732.5 1798 False False 2.31604598850287 0.0392471382871788 44.494064095996 0 0 0.000921564464586207 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gln308* Rv2752c_p.Gln308* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gln367Pro Rv2752c_p.Gln367Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 11.2104345733627 1 732.5 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 3 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gln367* Rv2752c_p.Gln367* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gln417* Rv2752c_p.Gln417* 2 stop_gained (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gln485Arg Rv2752c_p.Gln485Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gln531Glu Rv2752c_p.Gln531Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1508 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 741 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gln531Pro Rv2752c_p.Gln531Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1417 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 695 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gln548fs Rv2752c_p.Gln548fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1466 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 721 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Glu130Lys Rv2752c_p.Glu130Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1520 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Glu140fs Rv2752c_p.Glu140fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1444 1798 False False 4.63234191452137 0.0589984289392935 362.546724531758 0 0 0.000921564464586207 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 710 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Glu142Gly Rv2752c_p.Glu142Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1527 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 751 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Glu142* Rv2752c_p.Glu142* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Glu207* Rv2752c_p.Glu207* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1528 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Glu310Ala Rv2752c_p.Glu310Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Glu35Asp Rv2752c_p.Glu35Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Glu35fs Rv2752c_p.Glu35fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1431 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Glu464Gly Rv2752c_p.Glu464Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 4000 18535 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 1 0.999800997443015 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1541 1798 False False Inf 0.869940791113183 Inf 0 0 0.000921794749483055 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 758 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Glu464Lys Rv2752c_p.Glu464Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Glu499Gly Rv2752c_p.Glu499Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Glu505Gln Rv2752c_p.Glu505Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1542 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 759 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Glu516* Rv2752c_p.Glu516* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1467 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Glu543fs Rv2752c_p.Glu543fs 2 frameshift (see "Genomic_coordinates" sheet) 1 5 0 5 1 9 4001 18526 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999514432155381 0.999078442003892 0.999777944189974 0.1 0.00252857854446178 0.445016117028195 0 0 0.521823750104981 0 0 0.336267116879942 0 0 5.05488466210238 0.59375558807377 144 1798 False False 0.514482490488489 0.0117383297112304 3.71492514851402 0 0 0.000921564464586207 0.999514432155381 0.999078442003892 0.999777944189974 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 699 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 7 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Glu54Ala Rv2752c_p.Glu54Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 2 4000 18533 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 0.999892096034529 0.999610268708724 0.999986932062044 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 180.20051244703 1 732.5 1798 False False 4.63325 0.335715582549978 63.989229087488 0 0 0.000921794749483055 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 1741 6639 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999849397590361 0.999161185884076 0.99999618708438 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 148.399526333966 1 596 886 False False 0 0 0 0 0 0 0 3.81332567489948 0.0485516368820753 298.645085154332 0 0 0.00211658481469046 0.999849397590361 0.999161185884076 0.99999618708438 3 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Glu54Gly Rv2752c_p.Glu54Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Glu68Asp Rv2752c_p.Glu68Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1529 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 752 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 16 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gly104Ala Rv2752c_p.Gly104Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 4001 18533 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999892096034529 0.999610268708724 0.999986932062044 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6689469404428 1 732.5 1798 False False 2.31604598850287 0.0392471382871788 44.494064095996 0 0 0.000921564464586207 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 711 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gly15Arg Rv2752c_p.Gly15Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gly161Arg Rv2752c_p.Gly161Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1452 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gly161Cys Rv2752c_p.Gly161Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gly161Ser Rv2752c_p.Gly161Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 8 119 3994 18416 0.00199900049975012 0.000863409206250761 0.003935008292197 0.993579714054491 0.992322026150239 0.994678533771462 0.0629921259842519 0.027585296475011 0.120347927659983 NA NA NA 0 0 0.0305234448537962 NA NA NA NA 1543 1798 False True 0.309977571399115 0.130697260755224 0.631558036468572 0 0 0.00092317887936968 0.993579714054491 0.992322026150239 0.994678533771462 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 3 49 1739 6591 0.00172215843857634 0.000355291378803123 0.00502455256196275 0.99262048192771 0.990255490275854 0.994535749553658 0.0576923076923076 0.0120593180267384 0.159473358638591 NA NA NA 0 0 0.0725192636642774 NA NA NA NA 760 886 False True 0 1 1 0 0 0 0 0.232047505603736 0.0462188708467753 0.72052861991261 0 0 0.00211901648886052 0.99262048192771 0.990255490275854 0.994535749553658 97 5) Not assoc w R New NotAwR yes 5 +Moxifloxacin Rv2752c p.Gly169Val Rv2752c_p.Gly169Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1562 1798 False False 4.63234191452137 0.0589984289392935 362.546724531758 0 0 0.000921564464586207 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gly180Cys Rv2752c_p.Gly180Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1535 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 754 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gly187Asp Rv2752c_p.Gly187Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1445 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gly210Cys Rv2752c_p.Gly210Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1492 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gly22Cys Rv2752c_p.Gly22Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gly22Ser Rv2752c_p.Gly22Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1555 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gly256Ser Rv2752c_p.Gly256Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1480 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gly263fs Rv2752c_p.Gly263fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gly28Cys Rv2752c_p.Gly28Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1536 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gly28Ser Rv2752c_p.Gly28Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 14 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gly306Asp Rv2752c_p.Gly306Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1458 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 717 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gly321Thr Rv2752c_p.Gly321Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gly331fs Rv2752c_p.Gly331fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gly343Cys Rv2752c_p.Gly343Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gly350Glu Rv2752c_p.Gly350Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1501 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gly387Glu Rv2752c_p.Gly387Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1556 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gly38Ser Rv2752c_p.Gly38Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 11.2104345733627 1 732.5 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gly398Arg Rv2752c_p.Gly398Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gly414Ser Rv2752c_p.Gly414Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 3 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gly440Ser Rv2752c_p.Gly440Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gly451Asp Rv2752c_p.Gly451Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gly451Ser Rv2752c_p.Gly451Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gly46Cys Rv2752c_p.Gly46Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1537 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 755 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gly484Ser Rv2752c_p.Gly484Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1544 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gly496Ala Rv2752c_p.Gly496Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 2 3 4000 18532 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 0.999838144051794 0.999527061819887 0.99996662016845 0.4 0.0527449505263169 0.853367200365326 0 0 0.841886116991581 0 0 0.707598226178713 0 0 24.6737809278898 1 732.5 1798 False False 3.08866666666666 0.257877592435781 26.9864148134858 0 0 0.000921794749483055 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 4 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gly51Ser Rv2752c_p.Gly51Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gly542Glu Rv2752c_p.Gly542Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gly56fs Rv2752c_p.Gly56fs 2 frameshift (see "Genomic_coordinates" sheet) 1 7 0 7 0 8 4002 18527 0 0 0.000921334294721226 0.999568384138117 0.999149722782159 0.999813641077243 0 0 0.369416647552819 0 0 0.409616397225003 0 0 0.369416647552819 0 0 3.2132507580148 0.615314823004161 181.5 1798 False False 0 0 2.7132714326819 0 0 0.000921334294721226 0.999568384138117 0.999149722782159 0.999813641077243 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 1742 6636 0 0 0.00211537106925253 0.999397590361445 0.998458316867766 0.999835840034063 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.77543554850383 0.5866324014095 78.5 886 False False 0 0 0 0 0 0 0 0 0 5.77543554850383 0 0 0.00211537106925253 0.999397590361445 0.998458316867766 0.999835840034063 5 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gly56Val Rv2752c_p.Gly56Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gly82Glu Rv2752c_p.Gly82Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 3 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gly88Arg Rv2752c_p.Gly88Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gly88Glu Rv2752c_p.Gly88Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 5 0 3997 18535 0.00124937531234382 0.000405789275012681 0.0029131967931525 1 0.999800997443015 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 1538 1798 False False Inf 4.24707467079201 Inf 0 0 0.00092248629522778 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 1740 6640 0.00114810562571756 0.000139071172424607 0.00414113746933503 1 0.999444600156968 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 756 886 False False 0 0 0 0 0 0 0 Inf 0.716065670156237 Inf 0 0 0.00211779995375925 1 0.999444600156968 1 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Gly88Val Rv2752c_p.Gly88Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1459 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.His136Asp Rv2752c_p.His136Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 11.2104345733627 1 732.5 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.His148Arg Rv2752c_p.His148Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1423 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.His148dup Rv2752c_p.His148dup 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.His148Pro Rv2752c_p.His148Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 4001 18533 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999892096034529 0.999610268708724 0.999986932062044 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6689469404428 1 732.5 1798 False False 2.31604598850287 0.0392471382871788 44.494064095996 0 0 0.000921564464586207 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 742 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.His148Tyr Rv2752c_p.His148Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 3 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.His167Arg Rv2752c_p.His167Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 2 5 4000 18530 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 0.999730240086323 0.999370583585258 0.99991240407437 0.285714285714285 0.0366925661760855 0.709579136262657 0 0 0.707598226178713 0 0 0.521823750104981 0 0 11.2148287056984 1 732.5 1798 False False 1.853 0.176375644908091 11.3239281818414 0 0 0.000921794749483055 0.999730240086323 0.999370583585258 0.99991240407437 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 4 1742 6636 0 0 0.00211537106925253 0.999397590361445 0.998458316867766 0.999835840034063 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 20.2989864606705 1 98.5 886 False False 0 0 0 0 0 0 0 0 0 5.77543554850383 0 0 0.00211537106925253 0.999397590361445 0.998458316867766 0.999835840034063 4 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.His223Tyr Rv2752c_p.His223Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.His371Asp Rv2752c_p.His371Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1439 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.His371Tyr Rv2752c_p.His371Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 3 4001 18532 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999838144051794 0.999527061819887 0.99996662016845 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 24.6676166728131 1 732.5 1798 False False 1.5439473464967 0.0294026895471131 19.2327580431529 0 0 0.000921564464586207 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 690 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 4 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.His375Arg Rv2752c_p.His375Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1472 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.His375fs Rv2752c_p.His375fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1481 1798 False False 4.63234191452137 0.0589984289392935 362.546724531758 0 0 0.000921564464586207 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.His375Tyr Rv2752c_p.His375Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 180.110710654533 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.His397Tyr Rv2752c_p.His397Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 3 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.His491_Gln531del Rv2752c_p.His491_Gln531del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.His491fs Rv2752c_p.His491fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 180.16529327284 1 732.5 1798 False False 4.63234191452137 0.0589984289392935 362.546724531758 0 0 0.000921564464586207 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.His491Tyr Rv2752c_p.His491Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 9 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.His493Arg Rv2752c_p.His493Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1453 1798 False False 4.63234191452137 0.0589984289392935 362.546724531758 0 0 0.000921564464586207 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.His493Pro Rv2752c_p.His493Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 11.2098299448075 1 732.5 1798 False False 0 0 7.01683899052165 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 5 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.His52Asp Rv2752c_p.His52Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.His66Tyr Rv2752c_p.His66Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1515 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.His81Arg Rv2752c_p.His81Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1454 1798 False False 4.63234191452137 0.0589984289392935 362.546724531758 0 0 0.000921564464586207 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 1741 6639 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999849397590361 0.999161185884076 0.99999618708438 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 148.399526333966 1 596 886 False False 0 0 0 0 0 0 0 3.81332567489948 0.0485516368820753 298.645085154332 0 0 0.00211658481469046 0.999849397590361 0.999161185884076 0.99999618708438 5 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.His81Tyr Rv2752c_p.His81Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 11.2104345733627 1 732.5 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 6 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.His83Arg Rv2752c_p.His83Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 5 4001 18530 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999730240086323 0.999370583585258 0.99991240407437 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.707598226178713 0 0 0.521823750104981 0 0 11.2120263107716 1 732.5 1798 False False 0.926268432891777 0.0195789744788398 8.28271147593069 0 0 0.000921564464586207 0.999730240086323 0.999370583585258 0.99991240407437 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 704 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 5 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.His83Asn Rv2752c_p.His83Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.His83Pro Rv2752c_p.His83Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 1 6 4001 18529 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999676288103587 0.999295549654279 0.999881194471086 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.602364635616474 0 0 0.4592581264399 0 0 7.01783576095526 1 198.5 1798 False False 0.771848704490544 0.0167759984530013 6.36465776860659 0 0 0.000921564464586207 0.999676288103587 0.999295549654279 0.999881194471086 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 4 1741 6636 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999397590361445 0.998458316867766 0.999835840034063 0.2 0.00505076337946806 0.716417936118089 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.2317643698701 1 98.5 886 False False 0 0 0 0 0 0 0 0.952900631820792 0.0193382014380594 9.63481227974485 0 0 0.00211658481469046 0.999397590361445 0.998458316867766 0.999835840034063 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.His83Tyr Rv2752c_p.His83Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.His86Arg Rv2752c_p.His86Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 180.16529327284 1 732.5 1798 False False 4.63234191452137 0.0589984289392935 362.546724531758 0 0 0.000921564464586207 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.His86fs Rv2752c_p.His86fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1493 1798 False False 4.63234191452137 0.0589984289392935 362.546724531758 0 0 0.000921564464586207 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 735 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ile234Arg Rv2752c_p.Ile234Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ile234Val Rv2752c_p.Ile234Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ile248Thr Rv2752c_p.Ile248Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ile249Ser Rv2752c_p.Ile249Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ile24Val Rv2752c_p.Ile24Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1397 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 682 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ile287Val Rv2752c_p.Ile287Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ile358dup Rv2752c_p.Ile358dup 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ile438Thr Rv2752c_p.Ile438Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ile43fs Rv2752c_p.Ile43fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 4000 18535 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 1 0.999800997443015 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1545 1798 False False Inf 0.869940791113183 Inf 0 0 0.000921794749483055 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ile43Ser Rv2752c_p.Ile43Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1539 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 757 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ile453Thr Rv2752c_p.Ile453Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ile527Val Rv2752c_p.Ile527Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1563 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ile529fs Rv2752c_p.Ile529fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ile60fs Rv2752c_p.Ile60fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Leu109Trp Rv2752c_p.Leu109Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Leu111Arg Rv2752c_p.Leu111Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1502 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 739 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Leu111Pro Rv2752c_p.Leu111Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1474 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Leu11fs Rv2752c_p.Leu11fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1460 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Leu166Pro Rv2752c_p.Leu166Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 2 4000 18533 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 0.999892096034529 0.999610268708724 0.999986932062044 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 180.20051244703 1 732.5 1798 False False 4.63325 0.335715582549978 63.989229087488 0 0 0.000921794749483055 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Leu176Ser Rv2752c_p.Leu176Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 5 4002 18530 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1497 1798 False False 0 0 5.05471226039473 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1742 6636 0 0 0.00211537106925253 0.999397590361445 0.998458316867766 0.999835840034063 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 737 886 False False 0 0 0 0 0 0 0 0 0 5.77543554850383 0 0 0.00211537106925253 0.999397590361445 0.998458316867766 0.999835840034063 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Leu185Pro Rv2752c_p.Leu185Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 11.2104345733627 1 732.5 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Leu191Pro Rv2752c_p.Leu191Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 180.16529327284 1 732.5 1798 False False 4.63234191452137 0.0589984289392935 362.546724531758 0 0 0.000921564464586207 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Leu199fs Rv2752c_p.Leu199fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1398 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 683 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Leu199Ser Rv2752c_p.Leu199Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 180.110710654533 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Leu21Pro Rv2752c_p.Leu21Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1432 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 703 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Leu222Arg Rv2752c_p.Leu222Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 180.110710654533 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 684 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Leu222Gln Rv2752c_p.Leu222Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.118754661339467 Inf 0.177574655011758 72.5 1798 False False Inf 0.118754661339467 Inf 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Leu222Pro Rv2752c_p.Leu222Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Leu225Pro Rv2752c_p.Leu225Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 3 4001 18532 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999838144051794 0.999527061819887 0.99996662016845 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 24.6676166728131 1 732.5 1798 False False 1.5439473464967 0.0294026895471131 19.2327580431529 0 0 0.000921564464586207 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Leu279Arg Rv2752c_p.Leu279Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Leu302_Thr305del Rv2752c_p.Leu302_Thr305del 2 inframe_deletion (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1521 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Leu315* Rv2752c_p.Leu315* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1405 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Leu333fs Rv2752c_p.Leu333fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1522 1798 False False 4.63234191452137 0.0589984289392935 362.546724531758 0 0 0.000921564464586207 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 747 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Leu37Val Rv2752c_p.Leu37Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1468 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Leu384Val Rv2752c_p.Leu384Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1455 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 714 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Leu403Met Rv2752c_p.Leu403Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1418 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 696 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Leu40fs Rv2752c_p.Leu40fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Leu41Ser Rv2752c_p.Leu41Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1494 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Leu41Trp Rv2752c_p.Leu41Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 180.110710654533 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Leu431Arg Rv2752c_p.Leu431Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1461 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Leu452Val Rv2752c_p.Leu452Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1557 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 768 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Leu468Phe Rv2752c_p.Leu468Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Leu487Phe Rv2752c_p.Leu487Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 29 0 29 1 30 4001 18505 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.998381440517939 0.997690205325877 0.998907706532097 0.032258064516129 0.000816370071846613 0.167021116230227 0 0 0.119444869069502 0 0 0.115703308222027 0 0 0.627740834710371 0.00593867790688541 28 1798 False False 0.154169790885611 0.00378162900379141 0.928020797768142 0 0 0.000921564464586207 0.998381440517939 0.997690205325877 0.998907706532097 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 19 0 19 1 19 1741 6621 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.997138554216867 0.995535089009573 0.998276370690197 0.05 0.0012650894979498 0.248732762772027 0 0 0.176466911806965 0 0 0.176466911806965 0 0 0.815967912169653 0.0204700059716892 18 886 False False 0 0 0 0 0 0 0 0.200157199431663 0.00481812982121118 1.26100129796652 0 0 0.00211658481469046 0.997138554216867 0.995535089009573 0.998276370690197 60 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Leu492Arg Rv2752c_p.Leu492Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 3 4001 18532 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999838144051794 0.999527061819887 0.99996662016845 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 24.6676166728131 1 732.5 1798 False False 1.5439473464967 0.0294026895471131 19.2327580431529 0 0 0.000921564464586207 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 1741 6638 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999698795180722 0.998912372612698 0.9999635206173 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 148.377228822259 1 345 886 False False 0 0 0 0 0 0 0 1.90637564618035 0.032294587677361 36.6438813236649 0 0 0.00211658481469046 0.999698795180722 0.998912372612698 0.9999635206173 3 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Leu504fs Rv2752c_p.Leu504fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 180.110710654533 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 723 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 3 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Leu504Pro Rv2752c_p.Leu504Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1486 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 733 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Leu515Arg Rv2752c_p.Leu515Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1546 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 761 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Leu5Phe Rv2752c_p.Leu5Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1440 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Leu5Val Rv2752c_p.Leu5Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Leu77Pro Rv2752c_p.Leu77Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Leu93Arg Rv2752c_p.Leu93Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 1 4 3 4 3999 18531 0.000749625187406296 0.000154617422592445 0.00218914487959466 0.999784192069058 0.999447539013843 0.999941196572055 0.428571428571428 0.0989882784425078 0.815948432359917 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 1.15847711927982 0.0235177290786357 11.7139956201019 1 198.5 1798 False False 3.47543135783946 0.50886084840853 20.5487304491316 0.00025 6.32943196513345e-06 0.00139211512196626 0.999784192069058 0.999447539013843 0.999941196572055 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 1742 6636 0 0 0.00211537106925253 0.999397590361445 0.998458316867766 0.999835840034063 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.77543554850383 0.5866324014095 78.5 886 False False 0 0 0 0 0 0 0 0 0 5.77543554850383 0 0 0.00211537106925253 0.999397590361445 0.998458316867766 0.999835840034063 6 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Leu93Met Rv2752c_p.Leu93Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 24.6614555089698 1 732.5 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Leu94Arg Rv2752c_p.Leu94Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1503 1798 False False 4.63234191452137 0.0589984289392935 362.546724531758 0 0 0.000921564464586207 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 740 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Leu94Phe Rv2752c_p.Leu94Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Leu94Pro Rv2752c_p.Leu94Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 4000 18535 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 1 0.999800997443015 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.118784342620711 Inf 0.177538161164359 60 1798 False False Inf 0.869940791113183 Inf 0.000249937515621094 6.32785000763801e-06 0.00139176737893813 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0977360898734989 Inf 0.207826294440467 35.5 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Lys115Glu Rv2752c_p.Lys115Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Lys172Glu Rv2752c_p.Lys172Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 180.101020147088 1 732.5 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 4 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Lys357Thr Rv2752c_p.Lys357Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 5 4002 18530 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1420 1798 False False 0 0 5.05471226039473 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 1742 6636 0 0 0.00211537106925253 0.999397590361445 0.998458316867766 0.999835840034063 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 698 886 False False 0 0 0 0 0 0 0 0 0 5.77543554850383 0 0 0.00211537106925253 0.999397590361445 0.998458316867766 0.999835840034063 10 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Lys435Glu Rv2752c_p.Lys435Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 10 0 10 0 17 4002 18518 0 0 0.000921334294721226 0.999082816293498 0.998531904853251 0.9994656187862 0 0 0.195064322969093 0 0 0.30849710781876 0 0 0.195064322969093 0 0 2.06531638131638 0.226217014141539 88 1798 False False 0 0 1.12191532231395 0 0 0.000921334294721226 0.999082816293498 0.998531904853251 0.9994656187862 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 0 14 1742 6626 0 0 0.00211537106925253 0.99789156626506 0.996464934386019 0.998846835239396 0 0 0.231635761650116 0 0 0.369416647552819 0 0 0.231635761650116 0 0 2.23074451431294 0.218514321644516 40 886 False False 0 0 0 0 0 0 0 0 0 1.14808555235978 0 0 0.00211537106925253 0.99789156626506 0.996464934386019 0.998846835239396 36 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Lys446fs Rv2752c_p.Lys446fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 180.110710654533 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Lys502fs Rv2752c_p.Lys502fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1564 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Met1? Rv2752c_p.Met1? 2 start_lost (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 180.110710654533 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 148.292249815985 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 5 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Met188Lys Rv2752c_p.Met188Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 0 8 4002 18527 0 0 0.000921334294721226 0.999568384138117 0.999149722782159 0.999813641077243 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 2.7132714326819 0.365167222786382 108.5 1798 False False 0 0 2.7132714326819 0 0 0.000921334294721226 0.999568384138117 0.999149722782159 0.999813641077243 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Met270Arg Rv2752c_p.Met270Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1462 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 718 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Met312Ile Rv2752c_p.Met312Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 9 4002 18526 0 0 0.000921334294721226 0.999514432155381 0.999078442003892 0.999777944189974 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1442 1798 False False 0 0 2.34636960420997 0 0 0.000921334294721226 0.999514432155381 0.999078442003892 0.999777944189974 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Met312Val Rv2752c_p.Met312Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 16 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Met318_Arg320del Rv2752c_p.Met318_Arg320del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 4001 18533 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999892096034529 0.999610268708724 0.999986932062044 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 180.155600359953 1 732.5 1798 False False 2.31604598850287 0.0392471382871788 44.494064095996 0 0 0.000921564464586207 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 1741 6639 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999849397590361 0.999161185884076 0.99999618708438 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 148.399526333966 1 596 886 False False 0 0 0 0 0 0 0 3.81332567489948 0.0485516368820753 298.645085154332 0 0 0.00211658481469046 0.999849397590361 0.999161185884076 0.99999618708438 3 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Met31Ile Rv2752c_p.Met31Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 100 2 98 18 153 3984 18382 0.00449775112443778 0.00266776479404919 0.00709910547036896 0.991745346641489 0.990335676960258 0.992997283780775 0.105263157894736 0.06358936954747 0.161253829991817 0.02 0.00243133682394254 0.0703839324710701 0.0129032258064516 0.00156647825822792 0.0458318896003843 0.094162363740677 0.0112385177025467 0.349618963128185 1.23033386266486e-06 15 1798 True False 0.542818332152137 0.312929543810326 0.88838407977107 0.000501756146512794 6.07707742834279e-05 0.00181132822470835 0.991745346641489 0.990335676960258 0.992997283780775 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 5 12 1737 6628 0.00287026406429391 0.000932603401686605 0.00668542657812442 0.998192771084337 0.996845265024717 0.999065840721332 0.294117647058823 0.103135514370319 0.559582718754337 0 0 0.30849710781876 0 0 0.264648469397051 0 0 1.70427141785147 0.231851929420675 49 886 False False 0 0 0 0 0 0 0 1.58990596814431 0.438183659868152 4.85588406642313 0 0 0.00212145375679475 0.998192771084337 0.996845265024717 0.999065840721332 208 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Met394Arg Rv2752c_p.Met394Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 180.110710654533 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 148.292249815985 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Met394fs Rv2752c_p.Met394fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1516 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Met447Thr Rv2752c_p.Met447Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 180.110710654533 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 5 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Phe125Leu Rv2752c_p.Phe125Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1540 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Phe139fs Rv2752c_p.Phe139fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Phe139Val Rv2752c_p.Phe139Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Phe144dup Rv2752c_p.Phe144dup 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Phe144Ser Rv2752c_p.Phe144Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Phe238Ser Rv2752c_p.Phe238Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1406 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Phe349fs Rv2752c_p.Phe349fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Phe448Leu Rv2752c_p.Phe448Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1495 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Phe472fs Rv2752c_p.Phe472fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Phe497Cys Rv2752c_p.Phe497Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1509 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Pro101Ala Rv2752c_p.Pro101Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 9 4002 18526 0 0 0.000921334294721226 0.999514432155381 0.999078442003892 0.999777944189974 0 0 0.336267116879942 0 0 0.602364635616474 0 0 0.336267116879942 0 0 7.01494587140789 1 1257 1798 False False 0 0 2.34636960420997 0 0 0.000921334294721226 0.999514432155381 0.999078442003892 0.999777944189974 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 8 1742 6632 0 0 0.00211537106925253 0.998795180722891 0.997627413333175 0.999479705585957 0 0 0.369416647552819 0 0 0.602364635616474 0 0 0.369416647552819 0 0 5.77195519992799 0.58659039952264 73 886 False False 0 0 0 0 0 0 0 0 0 2.23276380149116 0 0 0.00211537106925253 0.998795180722891 0.997627413333175 0.999479705585957 16 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Pro10Arg Rv2752c_p.Pro10Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1517 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Pro123Leu Rv2752c_p.Pro123Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 125 3 122 45 159 3957 18376 0.0112443778110944 0.00821322340311831 0.0150172229788094 0.991421634745076 0.989987006297219 0.992698712133742 0.220588235294117 0.165682392934133 0.283803847265639 0.024 0.00497698974905344 0.06853631611067 0.0185185185185185 0.00383536717195242 0.0531630764692423 0.114194807293155 0.023210872005757 0.342006559265353 1.87648055269257e-07 13 1798 True False 1.31431759337405 0.920510294274717 1.84385164849621 0.000757575757575757 0.00015625759048251 0.00221234617408647 0.991421634745076 0.989987006297219 0.992698712133742 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 34 2 32 16 46 1726 6594 0.00918484500574052 0.00525878585277117 0.0148728637571032 0.993072289156626 0.990770100282336 0.99492371048562 0.258064516129032 0.155269993464206 0.384972453328967 0.0588235294117647 0.00720491743904971 0.196773209335575 0.0416666666666666 0.00508646793003297 0.142540973201377 0.23877462340672 0.0276990166603614 0.937601820733754 0.0322029393809379 19 886 False False 0 0 0 0 0 0 0 1.32883268678522 0.700408271165795 2.39839291475336 0.0011574074074074 0.000140198153669466 0.00417463763054235 0.993072289156626 0.990770100282336 0.99492371048562 288 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Pro123Ser Rv2752c_p.Pro123Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1424 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 700 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Pro186Ser Rv2752c_p.Pro186Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 180.110710654533 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Pro209Ser Rv2752c_p.Pro209Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Pro213Ala Rv2752c_p.Pro213Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Pro213fs Rv2752c_p.Pro213fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Pro220Ala Rv2752c_p.Pro220Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1482 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Pro220fs Rv2752c_p.Pro220fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 4 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Pro220Leu Rv2752c_p.Pro220Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1547 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Pro390Leu Rv2752c_p.Pro390Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 41 0 41 1 44 4001 18491 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.997626112759644 0.996814462927177 0.998274616274055 0.0222222222222222 0.000562459715402258 0.117704331418294 0 0 0.0860438362940284 0 0 0.0804199397635758 0 0 0.435370346279594 0.000657429200151448 24 1798 True False 0.105036240939765 0.00260413655731209 0.617002924593191 0 0 0.000921564464586207 0.997626112759644 0.996814462927177 0.998274616274055 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 14 0 14 0 14 1742 6626 0 0 0.00211537106925253 0.99789156626506 0.996464934386019 0.998846835239396 0 0 0.231635761650116 0 0 0.231635761650116 0 0 0.231635761650116 0 0 1.14808555235978 0.0899435177113674 25 886 False False 0 0 0 0 0 0 0 0 0 1.14808555235978 0 0 0.00211537106925253 0.99789156626506 0.996464934386019 0.998846835239396 75 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Pro443Leu Rv2752c_p.Pro443Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Pro490Arg Rv2752c_p.Pro490Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 4000 18535 0.000499750124937531 6.05277896582088e-05 0.00180409125974765 1 0.999800997443015 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1565 1798 False False Inf 0.869940791113183 Inf 0 0 0.000921794749483055 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 1740 6640 0.00114810562571756 0.000139071172424607 0.00414113746933503 1 0.999444600156968 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 770 886 False False 0 0 0 0 0 0 0 Inf 0.716065670156237 Inf 0 0 0.00211779995375925 1 0.999444600156968 1 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Pro490fs Rv2752c_p.Pro490fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Pro549Gln Rv2752c_p.Pro549Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Pro549Ser Rv2752c_p.Pro549Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Pro553Leu Rv2752c_p.Pro553Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Pro55Ser Rv2752c_p.Pro55Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Pro62Leu Rv2752c_p.Pro62Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1523 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 748 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Pro6fs Rv2752c_p.Pro6fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 3999 18535 0.000749625187406296 0.000154617422592445 0.00218914487959466 1 0.999800997443015 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1426 1798 False False Inf 1.91440039171731 Inf 0 0 0.000922025149498025 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Pro7fs Rv2752c_p.Pro7fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 180.16529327284 1 732.5 1798 False False 4.63234191452137 0.0589984289392935 362.546724531758 0 0 0.000921564464586207 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Pro7Gln Rv2752c_p.Pro7Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Pro8fs Rv2752c_p.Pro8fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Pro8Ser Rv2752c_p.Pro8Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Pro91Leu Rv2752c_p.Pro91Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 7 3999 18528 0.000749625187406296 0.000154617422592445 0.00218914487959466 0.999622336120852 0.999222023868969 0.999848146482689 0.3 0.0667395111777345 0.652452850059997 0 0 0.975 0 0 0.409616397225003 0 0 180.196958222051 1 732.5 1798 False False 1.98563926695959 0.331180393877843 8.70310113743166 0 0 0.000922025149498025 0.999622336120852 0.999222023868969 0.999848146482689 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 712 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 94 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ser133fs Rv2752c_p.Ser133fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1548 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 762 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ser149Phe Rv2752c_p.Ser149Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1407 1798 False False 0 0 7.01683899052165 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ser189Leu Rv2752c_p.Ser189Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ser189* Rv2752c_p.Ser189* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1475 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 726 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ser216fs Rv2752c_p.Ser216fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ser240fs Rv2752c_p.Ser240fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1549 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ser240Phe Rv2752c_p.Ser240Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ser240Pro Rv2752c_p.Ser240Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1476 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 727 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ser284Ala Rv2752c_p.Ser284Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1558 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ser284fs Rv2752c_p.Ser284fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ser284Pro Rv2752c_p.Ser284Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1408 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 689 886 False False 0 0 0 0 0 0 0 0 0 9.22785363871091 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ser313Leu Rv2752c_p.Ser313Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 4001 18533 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999892096034529 0.999610268708724 0.999986932062044 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 180.155600359953 1 732.5 1798 False False 2.31604598850287 0.0392471382871788 44.494064095996 0 0 0.000921564464586207 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ser313Pro Rv2752c_p.Ser313Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ser313Trp Rv2752c_p.Ser313Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1411 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 691 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ser325Arg Rv2752c_p.Ser325Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ser337Leu Rv2752c_p.Ser337Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1559 1798 False False 0 0 7.01683899052165 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 769 886 False False 0 0 0 0 0 0 0 0 0 9.22785363871091 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ser337Pro Rv2752c_p.Ser337Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ser337Trp Rv2752c_p.Ser337Trp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1498 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ser338Leu Rv2752c_p.Ser338Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1560 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ser338Pro Rv2752c_p.Ser338Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ser339del Rv2752c_p.Ser339del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 2 0 2 1 3 4001 18532 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999838144051794 0.999527061819887 0.99996662016845 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 24.6676166728131 1 732.5 1798 False False 1.5439473464967 0.0294026895471131 19.2327580431529 0 0 0.000921564464586207 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 1741 6639 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999849397590361 0.999161185884076 0.99999618708438 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 148.399526333966 1 596 886 False False 0 0 0 0 0 0 0 3.81332567489948 0.0485516368820753 298.645085154332 0 0 0.00211658481469046 0.999849397590361 0.999161185884076 0.99999618708438 8 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ser339Pro Rv2752c_p.Ser339Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ser339* Rv2752c_p.Ser339* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.118754661339467 Inf 0.177574655011758 72.5 1798 False False Inf 0.118754661339467 Inf 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ser356Pro Rv2752c_p.Ser356Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 6 4002 18529 0 0 0.000921334294721226 0.999676288103587 0.999295549654279 0.999881194471086 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 5.0544394993781 0.593751589252307 129 1798 False False 0 0 3.93385874811763 0 0 0.000921334294721226 0.999676288103587 0.999295549654279 0.999881194471086 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 6 1742 6634 0 0 0.00211537106925253 0.999096385542168 0.998034257105878 0.999668319522948 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 4.15966552310285 0.59066833166921 93.5 886 False False 0 0 0 0 0 0 0 0 0 3.23733664541029 0 0 0.00211537106925253 0.999096385542168 0.998034257105878 0.999668319522948 6 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ser373Tyr Rv2752c_p.Ser373Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 180.110710654533 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ser419* Rv2752c_p.Ser419* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ser428Gly Rv2752c_p.Ser428Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ser437Gly Rv2752c_p.Ser437Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 4 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ser439Phe Rv2752c_p.Ser439Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 180.0913296367 1 732.5 1798 False False 0 0 7.01683899052165 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 725 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 3 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ser470Leu Rv2752c_p.Ser470Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1446 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ser494Leu Rv2752c_p.Ser494Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ser498Ala Rv2752c_p.Ser498Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1412 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 692 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ser498Pro Rv2752c_p.Ser498Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 25 11 3977 18524 0.00624687656171914 0.00404660854809457 0.00920789946868461 0.99940652818991 0.998938363693644 0.999703704968061 0.694444444444444 0.51892936999992 0.836526015371506 0 0 0.707598226178713 0 0 0.284914152918154 0 0 11.2760221600632 1 732.5 1798 False False 10.5858687452853 5.01873730756159 23.8460268417012 0 0 0.000927123250390445 0.99940652818991 0.998938363693644 0.999703704968061 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 18 6 1724 6634 0.010332950631458 0.0061351352530145 0.0162815242907784 0.999096385542168 0.998034257105878 0.999668319522948 0.75 0.53288719757733 0.902269590525467 0 0 0.975 0 0 0.4592581264399 0 0 149.746854325128 1 345 886 False False 0 0 0 0 0 0 0 11.5440835266821 4.38012007821158 35.5878853172363 0 0 0.00213743368942885 0.999096385542168 0.998034257105878 0.999668319522948 3 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Ter559Tyrext*? Rv2752c_p.Ter559Tyrext*? 2 stop_lost (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1487 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 10 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Thr164fs Rv2752c_p.Thr164fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1443 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 709 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Thr183Ile Rv2752c_p.Thr183Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1524 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 749 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Thr183Pro Rv2752c_p.Thr183Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1530 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 1741 6640 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 1 0.999444600156968 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 753 886 False False 0 0 0 0 0 0 0 Inf 0.0977360898734989 Inf 0 0 0.00211658481469046 1 0.999444600156968 1 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Thr204Arg Rv2752c_p.Thr204Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Thr305Asn Rv2752c_p.Thr305Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1463 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 719 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Thr329Ala Rv2752c_p.Thr329Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Thr329Pro Rv2752c_p.Thr329Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 5 4002 18530 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 11.2092253162358 1 732.5 1798 False False 0 0 5.05471226039473 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 148.292249815985 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 5 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Thr32Arg Rv2752c_p.Thr32Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1477 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 728 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Thr364Ile Rv2752c_p.Thr364Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 4001 18532 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999838144051794 0.999527061819887 0.99996662016845 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 11.2132358700375 1 732.5 1798 False False 1.5439473464967 0.0294026895471131 19.2327580431529 0 0 0.000921564464586207 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Thr364Pro Rv2752c_p.Thr364Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Thr461Ile Rv2752c_p.Thr461Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4002 18532 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 11.2104345733627 1 732.5 1798 False False 0 0 11.2104345733627 0 0 0.000921334294721226 0.999838144051794 0.999527061819887 0.99996662016845 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 4 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Thr461Pro Rv2752c_p.Thr461Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1399 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 685 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Thr476fs Rv2752c_p.Thr476fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1510 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Thr476Pro Rv2752c_p.Thr476Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1531 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Thr536Ser Rv2752c_p.Thr536Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 180.110710654533 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Thr544fs Rv2752c_p.Thr544fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Thr554Pro Rv2752c_p.Thr554Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Thr80Ala Rv2752c_p.Thr80Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1550 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 763 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 5 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Thr80Pro Rv2752c_p.Thr80Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1504 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Trp400Arg Rv2752c_p.Trp400Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 180.110710654533 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 743 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Trp400* Rv2752c_p.Trp400* 2 stop_gained (see "Genomic_coordinates" sheet) 1 13 0 13 0 13 4002 18522 0 0 0.000921334294721226 0.99929862422444 0.998800924705247 0.999626495767062 0 0 0.24705263800047 0 0 0.24705263800047 0 0 0.24705263800047 0 0 1.51934003385999 0.143387966930213 54 1798 False False 0 0 1.51934003385999 0 0 0.000921334294721226 0.99929862422444 0.998800924705247 0.999626495767062 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 7 1742 6633 0 0 0.00211537106925253 0.99894578313253 0.997829124235982 0.999576048424705 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 2.64457250939033 0.357314381934628 65 886 False False 0 0 0 0 0 0 0 0 0 2.64457250939033 0 0 0.00211537106925253 0.99894578313253 0.997829124235982 0.999576048424705 14 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Trp540Arg Rv2752c_p.Trp540Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Trp540fs Rv2752c_p.Trp540fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1505 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Trp540Gly Rv2752c_p.Trp540Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Trp540* Rv2752c_p.Trp540* 2 stop_gained (see "Genomic_coordinates" sheet) 1 2 1 1 1 2 4001 18533 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999892096034529 0.999610268708724 0.999986932062044 0.333333333333333 0.00840375865961264 0.905700675949754 0.5 0.012579117093425 0.987420882906574 0.333333333333333 0.00840375865961264 0.905700675949754 4.63209197700574 0.0589952456814626 362.527227860453 0.323635993519015 105 1798 False False 2.31604598850287 0.0392471382871788 44.494064095996 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Tyr159* Rv2752c_p.Tyr159* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Tyr385Asp Rv2752c_p.Tyr385Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 3 2 3999 18533 0.000749625187406296 0.000154617422592445 0.00218914487959466 0.999892096034529 0.999610268708724 0.999986932062044 0.6 0.146632799634673 0.947255049473683 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6812792139651 1 732.5 1798 False False 6.9516129032258 0.795983567419885 83.4550561301111 0 0 0.000922025149498025 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 10 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Tyr545Cys Rv2752c_p.Tyr545Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Val103Asp Rv2752c_p.Val103Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1473 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Val124Met Rv2752c_p.Val124Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Val128Gly Rv2752c_p.Val128Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1499 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Val138Ala Rv2752c_p.Val138Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1561 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Val138Leu Rv2752c_p.Val138Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Val146dup Rv2752c_p.Val146dup 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Val146fs Rv2752c_p.Val146fs 2 frameshift (see "Genomic_coordinates" sheet) 1 4 0 4 7 5 3995 18530 0.00174912543728135 0.000703519237747539 0.00360052552178143 0.999730240086323 0.999370583585258 0.99991240407437 0.583333333333333 0.276669685682105 0.848347770191569 0 0 0.602364635616474 0 0 0.521823750104981 0 0 7.02875760158259 1 198.5 1798 False False 6.49361702127659 1.77288166458287 25.9571080962191 0 0 0.000922947902467247 0.999730240086323 0.999370583585258 0.99991240407437 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Val211Ile Rv2752c_p.Val211Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1483 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 731 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Val218Leu Rv2752c_p.Val218Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 1 6 4001 18529 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999676288103587 0.999295549654279 0.999881194471086 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.602364635616474 0 0 0.4592581264399 0 0 7.01783576095526 1 198.5 1798 False False 0.771848704490544 0.0167759984530013 6.36465776860659 0 0 0.000921564464586207 0.999676288103587 0.999295549654279 0.999881194471086 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 1741 6638 0.000574052812858783 1.45336532742381e-05 0.00319422380886066 0.999698795180722 0.998912372612698 0.9999635206173 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3167233028695 1 345 886 False False 0 0 0 0 0 0 0 1.90637564618035 0.032294587677361 36.6438813236649 0 0 0.00211658481469046 0.999698795180722 0.998912372612698 0.9999635206173 9 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Val245Ile Rv2752c_p.Val245Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 5 4002 18530 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 11.2092253162358 1 732.5 1798 False False 0 0 5.05471226039473 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 1742 6638 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3050873563561 1 345 886 False False 0 0 0 0 0 0 0 0 0 20.3050873563561 0 0 0.00211537106925253 0.999698795180722 0.998912372612698 0.9999635206173 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Val259Ala Rv2752c_p.Val259Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Val272Ala Rv2752c_p.Val272Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 7 4002 18528 0 0 0.000921334294721226 0.999622336120852 0.999222023868969 0.999848146482689 0 0 0.409616397225003 0 0 0.521823750104981 0 0 0.409616397225003 0 0 5.0541667383638 0.593749131854904 126 1798 False False 0 0 3.21342445526953 0 0 0.000921334294721226 0.999622336120852 0.999222023868969 0.999848146482689 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 14 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Val281Glu Rv2752c_p.Val281Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Val300Ala Rv2752c_p.Val300Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 33 1 32 11 52 3991 18483 0.00274862568715642 0.00137287782368726 0.00491271640366202 0.997194496897761 0.996322563446797 0.997904027910581 0.174603174603174 0.0905189845629966 0.290970949080872 0.0303030303030303 0.000766912075048109 0.157593972272496 0.0188679245283018 0.000477580412422113 0.100701526769146 0.144724066649962 0.00355726326897543 0.866969612023576 0.0213374208301665 34 1798 False False 0.97967060501513 0.46050810118806 1.90267562063755 0.000250501002004008 6.34211615730598e-06 0.00139490333451783 0.997194496897761 0.996322563446797 0.997904027910581 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 15 1 14 7 26 1735 6614 0.00401836969001148 0.00161707270669399 0.00826174702450177 0.996084337349397 0.994267874481466 0.997440613016852 0.212121212121212 0.0898042445427013 0.389080919674113 0.0666666666666666 0.0016864302413527 0.319484566578303 0.037037037037037 0.000937257091944708 0.189705617413044 0.272293124742692 0.00643959278267653 1.79221815751275 0.334253262310724 56 886 False False 0 0 0 0 0 0 0 1.02633562403014 0.3754755964113 2.43298538362259 0.000576036866359447 1.4583884428484e-05 0.00320524921924429 0.996084337349397 0.994267874481466 0.997440613016852 152 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Val335Met Rv2752c_p.Val335Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 4002 18530 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 5.05471226039473 0.593754047365944 137.5 1798 False False 0 0 5.05471226039473 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Val348fs Rv2752c_p.Val348fs 2 frameshift (see "Genomic_coordinates" sheet) 1 16 3 13 19 14 3983 18521 0.00474762618690654 0.00286072826565278 0.00740411988297862 0.999244672241704 0.998733012789936 0.999586995715357 0.575757575757575 0.392153016187885 0.745238177265304 0.1875 0.0404737339059459 0.456456546231611 0.176470588235294 0.0379850680706259 0.434317872844283 1.07307982000424 0.19604884157812 3.9075712437155 1 732.5 1798 False False 6.31073132240594 2.99655820669388 13.6080720306017 0.000752634219769192 0.000155238172115914 0.00219792585709306 0.999244672241704 0.998733012789936 0.999586995715357 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 16 3 13 14 14 1728 6626 0.00803673938002296 0.00440052340086954 0.0134475529232251 0.99789156626506 0.996464934386019 0.998846835239396 0.5 0.306470961532318 0.693529038467682 0.1875 0.0404737339059459 0.456456546231611 0.176470588235294 0.0379850680706259 0.434317872844283 0.884882478632478 0.161553655048243 3.22536486780877 1 345 886 False False 0 0 0 0 0 0 0 3.83449074074074 1.69058836844145 8.69445438915322 0.00173310225303292 0.000357550053598597 0.00505642892590357 0.99789156626506 0.996464934386019 0.998846835239396 43 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Val351Ala Rv2752c_p.Val351Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 5 4002 18530 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1433 1798 False False 0 0 5.05471226039473 0 0 0.000921334294721226 0.999730240086323 0.999370583585258 0.99991240407437 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Val372fs Rv2752c_p.Val372fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1469 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Val388fs Rv2752c_p.Val388fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1447 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Val415Gly Rv2752c_p.Val415Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1413 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Val415Ile Rv2752c_p.Val415Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Val432fs Rv2752c_p.Val432fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1400 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 686 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Val457Ile Rv2752c_p.Val457Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Val473Gly Rv2752c_p.Val473Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Val477Ile Rv2752c_p.Val477Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 24.6627854419351 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Val47fs Rv2752c_p.Val47fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Val47Met Rv2752c_p.Val47Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Val511Gly Rv2752c_p.Val511Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4002 18533 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 180.110710654533 1 732.5 1798 False False 0 0 24.6627854419351 0 0 0.000921334294721226 0.999892096034529 0.999610268708724 0.999986932062044 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Val523Phe Rv2752c_p.Val523Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1448 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Val533Ala Rv2752c_p.Val533Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 4 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Val533Gly Rv2752c_p.Val533Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4001 18535 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 1 0.999800997443015 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1401 1798 False False Inf 0.118754661339467 Inf 0 0 0.000921564464586207 1 0.999800997443015 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Val537Phe Rv2752c_p.Val537Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 4001 18534 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 4.63234191452137 0.0589984289392935 362.546724531758 0.323623032303333 101.5 1798 False False 4.63234191452137 0.0589984289392935 362.546724531758 0.000249875062468765 6.32626884072353e-06 0.00139141980959533 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Val552Ala Rv2752c_p.Val552Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 0 0 0.975 0 0 0.975 0 0 180.120401159035 1 732.5 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Val555Ala Rv2752c_p.Val555Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1506 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Val558fs Rv2752c_p.Val558fs 2 frameshift (see "Genomic_coordinates" sheet) 1 7 0 7 0 7 4002 18528 0 0 0.000921334294721226 0.999622336120852 0.999222023868969 0.999848146482689 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 3.21342445526953 0.615309777551834 178.5 1798 False False 0 0 3.21342445526953 0 0 0.000921334294721226 0.999622336120852 0.999222023868969 0.999848146482689 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 1742 6637 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.22785363871091 1 345 886 False False 0 0 0 0 0 0 0 0 0 9.22785363871091 0 0 0.00211537106925253 0.999548192771084 0.998680200855815 0.999906816794257 3 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Val558Gly Rv2752c_p.Val558Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 4002 18531 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 7.01683899052165 1 732.5 1798 False False 0 0 7.01683899052165 0 0 0.000921334294721226 0.999784192069058 0.999447539013843 0.999941196572055 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 1742 6639 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.314534587063 1 345 886 False False 0 0 0 0 0 0 0 0 0 148.314534587063 0 0 0.00211537106925253 0.999849397590361 0.999161185884076 0.99999618708438 1 3) Uncertain significance New Uncertain no 0 +Moxifloxacin Rv2752c p.Val57Gly Rv2752c_p.Val57Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4002 18534 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1566 1798 False False 0 0 180.120401159035 0 0 0.000921334294721226 0.999946048017264 0.999699435860871 0.999998634054993 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 c.1005C>T clpC1_c.1005C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 3 5 4406 16817 0.000680426400544341 0.000140342268876931 0.00198719451371054 0.999702770181904 0.999306502227134 0.999903483469113 0.375 0.0852334141372535 0.755136783633448 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.2901044030867 0.355484633702375 11.7779502227584 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 3 5 3783 16041 0.000792393026941363 0.000163440311798119 0.00231394549068866 0.999688395861897 0.99927297097682 0.999898815491092 0.375 0.0852334141372535 0.755136783633448 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.5441712926249 0.394894449816007 13.0803425612061 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1014G>A clpC1_c.1014G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1017G>A clpC1_c.1017G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1023C>A clpC1_c.1023C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1029G>A clpC1_c.1029G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 15 4409 16807 0 0 0.000836320411980403 0.999108310545714 0.998529719637006 0.999500845014484 0 0 0.218019360910534 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.06332174004809 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 15 3786 16031 0 0 0.000973872929872615 0.999065187585691 0.998458637051574 0.999476701181019 0 0 0.218019360910534 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.18122215318362 NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.102T>C clpC1_c.102T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1038G>A clpC1_c.1038G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.-105G>A clpC1_c.-105G>A 1 upstream_gene_variant 4040809 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 c.1062C>T clpC1_c.1062C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 9 4409 16813 0 0 0.000836320411980403 0.999464986327428 0.998984621445092 0.999755329427402 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.9328143827158 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 9 3786 16037 0 0 0.000973872929872615 0.999439112551414 0.998935529133907 0.999743495490327 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.14715011586227 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.-109_-104delACCAGG clpC1_c.-109_-104delACCAGG 1 upstream_gene_variant 4040807 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 c.1098C>T clpC1_c.1098C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1107C>T clpC1_c.1107C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1111C>A clpC1_c.1111C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 4409 16818 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.78028251232769 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 3786 16042 0 0 0.000973872929872615 0.999750716689517 0.999361859844744 0.999932074644789 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.42109836734015 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1113G>A clpC1_c.1113G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 9 4407 16813 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.999464986327428 0.998984621445092 0.999755329427402 0.181818181818181 0.0228311982999596 0.517755852360172 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.847792653102387 0.0891068669426637 4.09836797956212 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 2 9 3784 16037 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999439112551414 0.998935529133907 0.999743495490327 0.181818181818181 0.0228311982999596 0.517755852360172 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.941801738313366 0.0989816794216474 4.55283747206664 NA NA NA NA NA NA 26 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1128T>C clpC1_c.1128T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1167C>T clpC1_c.1167C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 3 4407 16819 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.999821662109142 0.999478910338162 0.999963220929399 0.4 0.0527449505263169 0.853367200365326 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.5442856062325 0.212429984141661 22.2163543346012 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 2 3 3784 16043 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999813037517138 0.999453714469566 0.999961442181588 0.4 0.0527449505263169 0.853367200365326 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.82646229739253 0.235979261609975 24.6811314932427 NA NA NA NA NA NA 14 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1170C>T clpC1_c.1170C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1203C>T clpC1_c.1203C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1212C>T clpC1_c.1212C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1224T>G clpC1_c.1224T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 18 4409 16804 0 0 0.000836320411980403 0.998929972654856 0.998309420654136 0.99936571457723 0 0 0.185301968137852 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.867306718440374 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 18 3786 16028 0 0 0.000973872929872615 0.998878225102829 0.998227689237744 0.999335033867569 0 0 0.185301968137852 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.963452773874723 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.123G>C clpC1_c.123G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1248C>G clpC1_c.1248C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1251A>G clpC1_c.1251A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1257A>G clpC1_c.1257A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1261C>T clpC1_c.1261C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 1 4407 16821 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.99994055403638 0.999668833292177 0.99999849495964 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 7.63376446562287 0.397281353658273 449.052313013199 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 2 1 3784 16045 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999937679172379 0.999652820032955 0.999998422174497 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 8.48044397463002 0.441282441622781 498.676520130596 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1287C>T clpC1_c.1287C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1323C>T clpC1_c.1323C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.132T>C clpC1_c.132T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1344C>T clpC1_c.1344C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1353C>T clpC1_c.1353C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1369C>T clpC1_c.1369C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1386T>C clpC1_c.1386T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1425G>T clpC1_c.1425G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1431G>C clpC1_c.1431G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1443C>T clpC1_c.1443C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.144A>C clpC1_c.144A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 4408 16820 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999881108072762 0.999570588169705 0.999985601311719 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.9078947368421 0.0323314320919459 36.6634061310851 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 2 3785 16044 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999875358344758 0.999549824781286 0.999984904960856 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.11941875825627 0.0359146288488272 40.7195918479678 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.145C>T clpC1_c.145C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1461G>A clpC1_c.1461G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1476C>A clpC1_c.1476C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0978301145652783 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1479T>C clpC1_c.1479T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1494G>A clpC1_c.1494G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1545C>T clpC1_c.1545C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.154T>C clpC1_c.154T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1590G>A clpC1_c.1590G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0978301145652783 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.-15A>G clpC1_c.-15A>G 1 upstream_gene_variant 4040719 1 62 11 51 56 59 4353 16763 0.012701292810161 0.00960829536135841 0.0164623537043234 0.996492688146474 0.995478124644815 0.997329031982847 0.48695652173913 0.392662542521972 0.581938486790671 0.177419354838709 0.0920383959179528 0.295313321470651 0.157142857142857 0.0811437635504477 0.263799765216311 0.830587874938627 0.389993245572298 1.61546560212145 0.640627744319724 570 1830 False False 3.65509856829694 2.4854103149078 5.36824780013822 0.00252062328139321 0.00125893673655317 0.00450560534077488 0.996492688146474 0.995478124644815 0.997329031982847 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 61 11 50 54 58 3732 15988 0.0142630744849445 0.0107325395351345 0.0185696871845745 0.996385391998005 0.995329754362934 0.997254166994499 0.482142857142857 0.386727992881064 0.578525235801939 0.180327868852459 0.0936097697943499 0.299786377267992 0.159420289855072 0.0823622478254447 0.267368095876403 0.942486602357985 0.442005712585762 1.83639601424139 1 554.5 1762 False False 0 0 0 0 0 0 0 3.98857966515134 2.69635068251893 5.89006935620521 0.00293881912904087 0.0014679325617844 0.00525226129594212 0.996385391998005 0.995329754362934 0.997254166994499 342 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 c.1605C>T clpC1_c.1605C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1606C>A clpC1_c.1606C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1611C>A clpC1_c.1611C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1611C>T clpC1_c.1611C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1626C>G clpC1_c.1626C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1626C>T clpC1_c.1626C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1647C>T clpC1_c.1647C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1659C>T clpC1_c.1659C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1689C>T clpC1_c.1689C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 3 4408 16819 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999821662109142 0.999478910338162 0.999963220929399 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.2718542044767 0.0242215257537785 15.8425197757275 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 3 3785 16043 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999813037517138 0.999453714469566 0.999961442181588 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.41285777190664 0.0269058536042688 17.5998124179982 NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1692G>A clpC1_c.1692G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 0 NA NA NA 1 2 4408 16820 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999881108072762 0.999570588169705 0.999985601311719 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.9078947368421 0.0323314320919459 36.6634061310851 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 NA NA NA 1 2 3785 16044 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999875358344758 0.999549824781286 0.999984904960856 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.11941875825627 0.0359146288488272 40.7195918479678 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1698G>A clpC1_c.1698G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1701C>T clpC1_c.1701C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1708T>C clpC1_c.1708T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.171A>G clpC1_c.171A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1722C>T clpC1_c.1722C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1731T>C clpC1_c.1731T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1737G>A clpC1_c.1737G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 139 391 4270 16431 0.0315264232252211 0.0265676053134917 0.037117809861318 0.976756628224943 0.974365821102195 0.978980572062214 0.262264150943396 0.225287199257177 0.301915838278564 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.36796240948268 1.11567159996846 1.6694149340263 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 139 389 3647 15657 0.0367142102482831 0.0309518423334318 0.043205095596996 0.97575719805559 0.973258288711109 0.97808153286202 0.263257575757575 0.226160670866649 0.303028157518694 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.53404460333985 1.25040622294881 1.87318156128869 NA NA NA NA NA NA 609 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1773G>A clpC1_c.1773G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 9 4409 16813 0 0 0.000836320411980403 0.999464986327428 0.998984621445092 0.999755329427402 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.9328143827158 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 9 3786 16037 0 0 0.000973872929872615 0.999439112551414 0.998935529133907 0.999743495490327 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.14715011586227 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1776G>A clpC1_c.1776G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1794G>A clpC1_c.1794G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.180C>T clpC1_c.180C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 3 4408 16819 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999821662109142 0.999478910338162 0.999963220929399 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.2718542044767 0.0242215257537785 15.8425197757275 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 3 3785 16043 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999813037517138 0.999453714469566 0.999961442181588 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.41285777190664 0.0269058536042688 17.5998124179982 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1827A>G clpC1_c.1827A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 15 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.183T>C clpC1_c.183T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 24 4408 16798 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.998573296873142 0.997877917781838 0.999085677166006 0.04 0.00101219969931084 0.203516913922414 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.158783272837265 0.00386406169153894 0.974325947165153 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 24 3785 16022 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.998504300137105 0.997775329312221 0.999041449122186 0.04 0.00101219969931084 0.203516913922414 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.176376045794804 0.00429154374793606 1.08236230283629 NA NA NA NA NA NA 51 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1842G>T clpC1_c.1842G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1845G>C clpC1_c.1845G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 12 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1857C>T clpC1_c.1857C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1863G>A clpC1_c.1863G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1872C>T clpC1_c.1872C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1881C>T clpC1_c.1881C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1915C>T clpC1_c.1915C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1923G>A clpC1_c.1923G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1926C>T clpC1_c.1926C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1956C>T clpC1_c.1956C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.716637886286628 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.1959C>T clpC1_c.1959C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.2002C>T clpC1_c.2002C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0978301145652783 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.2007C>T clpC1_c.2007C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.2013C>G clpC1_c.2013C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.2022T>C clpC1_c.2022T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.2034T>G clpC1_c.2034T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.204C>T clpC1_c.204C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.2073G>A clpC1_c.2073G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.2076G>T clpC1_c.2076G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.207G>A clpC1_c.207G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 4408 16820 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999881108072762 0.999570588169705 0.999985601311719 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.9078947368421 0.0323314320919459 36.6634061310851 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 2 3785 16044 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999875358344758 0.999549824781286 0.999984904960856 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.11941875825627 0.0359146288488272 40.7195918479678 NA NA NA NA NA NA 40 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.2151C>T clpC1_c.2151C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.2169C>T clpC1_c.2169C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.216G>A clpC1_c.216G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 4409 16817 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.16390782018879 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 5 3786 16041 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.62556638995023 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.2181C>T clpC1_c.2181C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.2211G>T clpC1_c.2211G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.2217C>T clpC1_c.2217C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.2220C>T clpC1_c.2220C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.2226C>T clpC1_c.2226C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.2232C>T clpC1_c.2232C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.2244G>A clpC1_c.2244G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.2247G>A clpC1_c.2247G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.225T>C clpC1_c.225T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 3 2 4406 16820 0.000680426400544341 0.000140342268876931 0.00198719451371054 0.999881108072762 0.999570588169705 0.999985601311719 0.6 0.146632799634673 0.947255049473683 NA NA NA NA NA NA NA NA NA NA NA NA False False 5.72628234226055 0.655677739135472 68.675028521871 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 3 2 3783 16044 0.000792393026941363 0.000163440311798119 0.00231394549068866 0.999875358344758 0.999549824781286 0.999984904960856 0.6 0.146632799634673 0.947255049473683 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 6.36161776367961 0.728392675067714 76.0575760881352 NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.2262G>A clpC1_c.2262G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.2262G>C clpC1_c.2262G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.2275C>T clpC1_c.2275C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.2277G>A clpC1_c.2277G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.2280C>T clpC1_c.2280C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.2302T>C clpC1_c.2302T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 163 2 4246 16820 0.0369698344295758 0.0315955022033961 0.0429681086332695 0.999881108072762 0.999570588169705 0.999985601311719 0.987878787878788 0.956901799424608 0.998528679274499 NA NA NA NA NA NA NA NA NA NA NA NA False False 322.852096090438 87.9661986093094 2755.75536343694 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 161 2 3625 16044 0.0425250924458531 0.0363210088677435 0.0494472014044384 0.999875358344758 0.999549824781286 0.999984904960856 0.987730061349693 0.956381461656562 0.998510584019953 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 356.287448275862 96.8825086100132 3083.50247184163 NA NA NA NA NA NA 68 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.234T>C clpC1_c.234T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.2361G>A clpC1_c.2361G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.2370C>T clpC1_c.2370C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 4409 16817 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.16390782018879 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 3786 16042 0 0 0.000973872929872615 0.999750716689517 0.999361859844744 0.999932074644789 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.42109836734015 NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.2373C>T clpC1_c.2373C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 15 17 4394 16805 0.0034021320027217 0.00190535929953375 0.005605100858211 0.998989418618475 0.998382452772912 0.999411192380357 0.46875 0.290939822906015 0.652563190713607 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.37458834239203 1.56786242408765 7.18912391583604 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 15 17 3771 16029 0.00396196513470681 0.002219125650155 0.0065262525797864 0.99894054593045 0.998304251550396 0.999382711664247 0.46875 0.290939822906015 0.652563190713607 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.75052646356872 1.74221336752362 7.9909990382239 NA NA NA NA NA NA 26 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.2397G>A clpC1_c.2397G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.716637886286628 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.2406C>T clpC1_c.2406C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.2415C>T clpC1_c.2415C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0978301145652783 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.2418C>T clpC1_c.2418C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 658 2258 3751 14564 0.149240190519392 0.138843916428681 0.160103377756217 0.865771014148139 0.860526527554943 0.870888685455985 0.225651577503429 0.210589390698622 0.241266223601877 NA NA NA NA NA NA NA NA NA NA NA NA False True 1.13145050897558 1.02834663279773 1.24379216178148 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 381 2015 3405 14031 0.100633914421553 0.0912299202166803 0.110659364181384 0.874423532344509 0.869197231901046 0.879513685401088 0.159015025041736 0.14458733296512 0.174281470137598 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 0 0.77915064330298 0.692143596917304 0.875450686956302 NA NA NA NA NA NA 3495 5) Not assoc w R Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.2439C>T clpC1_c.2439C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.2445C>T clpC1_c.2445C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.23555131695149 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.2590571436125 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.2457C>T clpC1_c.2457C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 24 4409 16798 0 0 0.000836320411980403 0.998573296873142 0.997877917781838 0.999085677166006 0 0 0.142473597722525 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.633335850709692 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 23 3786 16023 0 0 0.000973872929872615 0.998566620964726 0.997849999215428 0.99909115045139 0 0 0.148185128915224 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.736663734603758 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.2460C>T clpC1_c.2460C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 12 4409 16810 0 0 0.000836320411980403 0.999286648436571 0.998754250286254 0.999631348241016 0 0 0.264648469397051 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.37280707722974 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 12 3786 16034 0 0 0.000973872929872615 0.999252150068553 0.998694021458847 0.999613517219799 0 0 0.264648469397051 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.52501633506388 NA NA NA NA NA NA 12 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.2463C>T clpC1_c.2463C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.2478G>T clpC1_c.2478G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.2481G>A clpC1_c.2481G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 4409 16818 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.78028251232769 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 3786 16042 0 0 0.000973872929872615 0.999750716689517 0.999361859844744 0.999932074644789 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.42109836734015 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.2490G>A clpC1_c.2490G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0978301145652783 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.249C>T clpC1_c.249C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.-24G>T clpC1_c.-24G>T 1 upstream_gene_variant 4040728 1 3 0 3 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.23555131695149 1 1273 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 10.2590571436125 1 554.5 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 2 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 c.2508A>G clpC1_c.2508A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.2517C>T clpC1_c.2517C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.23555131695149 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.2590571436125 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.2520G>C clpC1_c.2520G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.2535G>T clpC1_c.2535G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.23555131695149 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.2590571436125 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.255A>G clpC1_c.255A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.267G>A clpC1_c.267G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.273C>T clpC1_c.273C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.27C>T clpC1_c.27C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.282A>G clpC1_c.282A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.294T>C clpC1_c.294T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 3 1 4406 16821 0.000680426400544341 0.000140342268876931 0.00198719451371054 0.99994055403638 0.999668833292177 0.99999849495964 0.75 0.194120449683243 0.99369053679029 NA NA NA NA NA NA NA NA NA NA NA NA False False 11.4532455742169 0.919224933680734 599.12689591493 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 3 1 3783 16045 0.000792393026941363 0.000163440311798119 0.00231394549068866 0.999937679172379 0.999652820032955 0.999998422174497 0.75 0.194120449683243 0.99369053679029 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 12.7240285487708 1.02115021686679 665.307410149575 NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.-29C>T clpC1_c.-29C>T 1 upstream_gene_variant 4040733 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 c.300C>T clpC1_c.300C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 11 4409 16811 0 0 0.000836320411980403 0.99934609440019 0.998830284178405 0.999673528922672 0 0 0.284914152918154 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.51991683293768 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 11 3786 16035 0 0 0.000973872929872615 0.999314470896173 0.998773730902855 0.999657738248111 0 0 0.284914152918154 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.68837982812114 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.30C>G clpC1_c.30C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0978301145652783 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf NA NA NA NA NA NA 20 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.312G>C clpC1_c.312G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.330G>A clpC1_c.330G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.336C>T clpC1_c.336C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.33G>A clpC1_c.33G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 4408 16821 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.81601633393829 0.0486026416232846 298.829108180248 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 3785 16045 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.23910171730515 0.0539892730999128 331.863925136224 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.342A>G clpC1_c.342A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.372G>A clpC1_c.372G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.378G>A clpC1_c.378G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.384C>A clpC1_c.384C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.23555131695149 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.2590571436125 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.387C>T clpC1_c.387C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 7 1 4402 16821 0.00158766160127012 0.000638553061192671 0.00326843667440656 0.99994055403638 0.999668833292177 0.99999849495964 0.875 0.473490329124793 0.996840276468748 NA NA NA NA NA NA NA NA NA NA NA NA False False 26.7485233984552 3.43432279452703 1197.87100642049 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.396C>G clpC1_c.396C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0978301145652783 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.402G>A clpC1_c.402G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.405C>G clpC1_c.405C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 7 4409 16815 0 0 0.000836320411980403 0.999583878254666 0.99914281931165 0.999832681632407 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.64713852578052 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 7 3786 16039 0 0 0.000973872929872615 0.999563754206656 0.999101374817905 0.99982458915172 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.94057641353956 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.408G>A clpC1_c.408G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.417C>T clpC1_c.417C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.426C>G clpC1_c.426C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 3 3 4406 16819 0.000680426400544341 0.000140342268876931 0.00198719451371054 0.999821662109142 0.999478910338162 0.999963220929399 0.5 0.118117248757025 0.881882751242974 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.81729459827507 0.51105828942184 28.5202711399627 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 3 3 3783 16043 0.000792393026941363 0.000163440311798119 0.00231394549068866 0.999813037517138 0.999453714469566 0.999961442181588 0.5 0.118117248757025 0.881882751242974 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.24081416864922 0.567733907706636 31.6728249153222 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.429C>G clpC1_c.429C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.432T>C clpC1_c.432T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.438A>G clpC1_c.438A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 11 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.43C>T clpC1_c.43C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.441C>T clpC1_c.441C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 4409 16817 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.16390782018879 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 5 3786 16041 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.62556638995023 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.459C>T clpC1_c.459C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.45G>A clpC1_c.45G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.462C>T clpC1_c.462C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.-46G>C clpC1_c.-46G>C 1 upstream_gene_variant 4040750 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 c.474C>A clpC1_c.474C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.48T>C clpC1_c.48T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.48T>G clpC1_c.48T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.492T>C clpC1_c.492T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.495G>A clpC1_c.495G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 4409 16818 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.78028251232769 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 3786 16042 0 0 0.000973872929872615 0.999750716689517 0.999361859844744 0.999932074644789 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.42109836734015 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.-49G>A clpC1_c.-49G>A 1 upstream_gene_variant 4040753 1 4 0 4 3 5 4406 16817 0.000680426400544341 0.000140342268876931 0.00198719451371054 0.999702770181904 0.999306502227134 0.999903483469113 0.375 0.0852334141372535 0.755136783633448 0 0 0.602364635616474 0 0 0.521823750104981 0 0 5.78387523725128 0.586809106537726 551 1830 False False 2.2901044030867 0.355484633702375 11.7779502227584 0 0 0.000836889615584862 0.999702770181904 0.999306502227134 0.999903483469113 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 3 4 3783 16042 0.000792393026941363 0.000163440311798119 0.00231394549068866 0.999750716689517 0.999361859844744 0.999932074644789 0.428571428571428 0.0989882784425078 0.815948432359917 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.42619175448591 1 554.5 1762 False False 0 0 0 0 0 0 0 3.18041237113402 0.465648963873201 18.8045847324481 0 0 0.000974644855475749 0.999750716689517 0.999361859844744 0.999932074644789 12 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 c.-52T>G clpC1_c.-52T>G 1 upstream_gene_variant 4040756 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 c.534C>T clpC1_c.534C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.543G>C clpC1_c.543G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 3 1 4406 16821 0.000680426400544341 0.000140342268876931 0.00198719451371054 0.99994055403638 0.999668833292177 0.99999849495964 0.75 0.194120449683243 0.99369053679029 NA NA NA NA NA NA NA NA NA NA NA NA False False 11.4532455742169 0.919224933680734 599.12689591493 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 3 1 3783 16045 0.000792393026941363 0.000163440311798119 0.00231394549068866 0.999937679172379 0.999652820032955 0.999998422174497 0.75 0.194120449683243 0.99369053679029 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 12.7240285487708 1.02115021686679 665.307410149575 NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.543G>T clpC1_c.543G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0978301145652783 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.546G>A clpC1_c.546G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.558A>G clpC1_c.558A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.579C>T clpC1_c.579C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.594G>A clpC1_c.594G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.-59C>T clpC1_c.-59C>T 1 upstream_gene_variant 4040763 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 c.600C>T clpC1_c.600C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.612C>G clpC1_c.612C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.612C>T clpC1_c.612C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 24 4408 16798 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.998573296873142 0.997877917781838 0.999085677166006 0.04 0.00101219969931084 0.203516913922414 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.158783272837265 0.00386406169153894 0.974325947165153 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 22 3785 16024 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.998628941792347 0.997924932910545 0.99914057190862 0.0434782608695652 0.0011001686304415 0.21948660745348 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.192434250030022 0.0046651542730535 1.19132779388638 NA NA NA NA NA NA 22 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.615T>C clpC1_c.615T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.-62G>A clpC1_c.-62G>A 1 upstream_gene_variant 4040766 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 c.642G>C clpC1_c.642G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.657C>T clpC1_c.657C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.660C>G clpC1_c.660C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.663C>T clpC1_c.663C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 7 4408 16815 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999583878254666 0.99914281931165 0.999832681632407 0.125 0.0031597235312519 0.526509670875206 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.544950738916256 0.0120922908650136 4.24367830015078 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 7 3785 16039 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999563754206656 0.999101374817905 0.99982458915172 0.125 0.0031597235312519 0.526509670875206 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.605359501792791 0.0134317907447528 4.71432113745169 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.-66C>T clpC1_c.-66C>T 1 upstream_gene_variant 4040770 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 c.684A>C clpC1_c.684A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 4408 16820 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999881108072762 0.999570588169705 0.999985601311719 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.9078947368421 0.0323314320919459 36.6634061310851 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 2 3785 16044 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999875358344758 0.999549824781286 0.999984904960856 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.11941875825627 0.0359146288488272 40.7195918479678 NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.690G>A clpC1_c.690G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.693G>A clpC1_c.693G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0978301145652783 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.69C>G clpC1_c.69C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.708C>T clpC1_c.708C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.714G>A clpC1_c.714G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 10 70 4399 16752 0.00226808800181447 0.00108815543692413 0.00416712622349087 0.995838782546665 0.994745435612624 0.99675473349986 0.125 0.0616020965584342 0.217889134069436 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.544019744747182 0.249757312490259 1.06207343880827 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 8 62 3778 15984 0.00211304807184363 0.00091269178353604 0.00415927925423806 0.996136108687523 0.995049365436898 0.997036332141464 0.114285714285714 0.0506521987903564 0.21282804216909 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 0 0.545910961594289 0.225545174388283 1.1452365796064 NA NA NA NA NA NA 101 5) Not assoc w R Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.-71C>T clpC1_c.-71C>T 1 upstream_gene_variant 4040775 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 c.723G>A clpC1_c.723G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0978301145652783 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.-73A>G clpC1_c.-73A>G 1 upstream_gene_variant 4040777 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 c.756G>A clpC1_c.756G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 4409 16817 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.16390782018879 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.2590571436125 NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.75C>T clpC1_c.75C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.780C>T clpC1_c.780C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.786C>A clpC1_c.786C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.23555131695149 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.2590571436125 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.786C>T clpC1_c.786C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.716637886286628 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.798G>A clpC1_c.798G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.-7G>T clpC1_c.-7G>T 1 upstream_gene_variant 4040711 0 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1363 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1308 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 2 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 c.816G>A clpC1_c.816G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 4409 16817 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.16390782018879 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 5 3786 16041 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.62556638995023 NA NA NA NA NA NA 20 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.-82G>A clpC1_c.-82G>A 1 upstream_gene_variant 4040786 1 7 1 6 6 6 4403 16816 0.00136085280108868 0.000499567554195151 0.00295963286153356 0.999643324218285 0.999223829869625 0.999869095386533 0.5 0.210944638239296 0.789055361760703 0.142857142857142 0.00361029686190058 0.578723197043195 0.142857142857142 0.00361029686190058 0.578723197043195 0.636535695359224 0.0138389521472075 5.24921985454383 1 1273 1830 False False 3.81921417215534 1.02040352544025 14.2927347253554 0.000227066303360581 5.74880454374554e-06 0.00126447601815069 0.999643324218285 0.999223829869625 0.999869095386533 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 1 6 6 6 3780 16040 0.00158478605388272 0.000581803608073282 0.0034461969631646 0.999626075034276 0.999186301793093 0.999862764161372 0.5 0.210944638239296 0.789055361760703 0.142857142857142 0.00361029686190058 0.578723197043195 0.142857142857142 0.00361029686190058 0.578723197043195 0.707231040564373 0.0153749138751067 5.83141337066137 1 927 1762 False False 0 0 0 0 0 0 0 4.24338624338624 1.13360738178737 15.8812021096249 0.000264480296217931 6.69603893670491e-06 0.00147269933727264 0.999626075034276 0.999186301793093 0.999862764161372 5 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 c.837C>T clpC1_c.837C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.852G>A clpC1_c.852G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 29 4408 16793 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.998276067055047 0.997525075697192 0.998845160492959 0.0333333333333333 0.000843570926630479 0.172169455633412 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.131367732649101 0.00321951935230726 0.792824589854799 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 29 3785 16017 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.998192695999002 0.997405433184333 0.998789296399478 0.0333333333333333 0.000843570926630479 0.172169455633412 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.14592083086594 0.00357555961337945 0.880733582721516 NA NA NA NA NA NA 32 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.852G>T clpC1_c.852G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.-85C>T clpC1_c.-85C>T 1 upstream_gene_variant 4040789 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1366 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1311 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 c.861C>T clpC1_c.861C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.870C>T clpC1_c.870C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.876G>A clpC1_c.876G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.882T>C clpC1_c.882T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.882T>G clpC1_c.882T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.885T>C clpC1_c.885T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 3 1 4406 16821 0.000680426400544341 0.000140342268876931 0.00198719451371054 0.99994055403638 0.999668833292177 0.99999849495964 0.75 0.194120449683243 0.99369053679029 NA NA NA NA NA NA NA NA NA NA NA NA False False 11.4532455742169 0.919224933680734 599.12689591493 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 3 1 3783 16045 0.000792393026941363 0.000163440311798119 0.00231394549068866 0.999937679172379 0.999652820032955 0.999998422174497 0.75 0.194120449683243 0.99369053679029 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 12.7240285487708 1.02115021686679 665.307410149575 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.888A>C clpC1_c.888A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.900C>T clpC1_c.900C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.909C>T clpC1_c.909C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.924G>A clpC1_c.924G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.942C>T clpC1_c.942C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0978301145652783 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.960C>T clpC1_c.960C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.23555131695149 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.2590571436125 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.987C>T clpC1_c.987C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide clpC1 c.-98C>G clpC1_c.-98C>G 1 upstream_gene_variant 4040802 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 c.-98C>T clpC1_c.-98C>T 1 upstream_gene_variant 4040802 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Ala151Thr clpC1_p.Ala151Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Ala181Ser clpC1_p.Ala181Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Ala232Asp clpC1_p.Ala232Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Ala232Thr clpC1_p.Ala232Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Ala232Val clpC1_p.Ala232Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Ala368Glu clpC1_p.Ala368Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1370 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1314 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Ala377Thr clpC1_p.Ala377Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Ala527Val clpC1_p.Ala527Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Ala531Ser clpC1_p.Ala531Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Ala567Thr clpC1_p.Ala567Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Ala567Val clpC1_p.Ala567Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Ala591Val clpC1_p.Ala591Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 7 4409 16815 0 0 0.000836320411980403 0.999583878254666 0.99914281931165 0.999832681632407 0 0 0.409616397225003 0 0 0.521823750104981 0 0 0.409616397225003 0 0 4.16341266380901 0.590724221935485 566 1830 False False 0 0 2.64713852578052 0 0 0.000836320411980403 0.999583878254666 0.99914281931165 0.999832681632407 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 7 3786 16039 0 0 0.000973872929872615 0.999563754206656 0.999101374817905 0.99982458915172 0 0 0.409616397225003 0 0 0.521823750104981 0 0 0.409616397225003 0 0 4.62498971249767 0.590886080524198 503 1762 False False 0 0 0 0 0 0 0 0 0 2.94057641353956 0 0 0.000973872929872615 0.999563754206656 0.999101374817905 0.99982458915172 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Ala755Thr clpC1_p.Ala755Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Ala757Val clpC1_p.Ala757Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1348 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1295 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 1 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Ala816Val clpC1_p.Ala816Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.23555131695149 1 1273 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 10.2590571436125 1 554.5 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 NA 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Ala828Val clpC1_p.Ala828Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1345 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1293 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Arg388Leu clpC1_p.Arg388Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Arg413Leu clpC1_p.Arg413Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1360 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1305 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Arg432Gly clpC1_p.Arg432Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1349 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Arg451His clpC1_p.Arg451His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1367 1830 False False Inf 0.716637886286628 Inf 0 0 0.000836699794980095 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1312 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0 0 0.000974387411009493 1 0.999770132403032 1 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Arg453Gln clpC1_p.Arg453Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Arg506Gly clpC1_p.Arg506Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1361 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1306 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Arg509Gly clpC1_p.Arg509Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 5 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Arg536Gln clpC1_p.Arg536Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Arg60Cys clpC1_p.Arg60Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Arg724Ser clpC1_p.Arg724Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Arg729Gly clpC1_p.Arg729Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1354 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1299 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Arg737Leu clpC1_p.Arg737Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.23555131695149 1 1273 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 10.2590571436125 1 554.5 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 3 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Arg737Trp clpC1_p.Arg737Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.097852308370781 Inf 0.207630711257654 334.5 1830 False False Inf 0.716637886286628 Inf 0.000226860254083484 5.74358785768897e-06 0.0012633291757201 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.108701618838585 Inf 0.190862790580404 314.5 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0.000264200792602377 6.68896256519433e-06 0.00147114392376758 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Arg848Leu clpC1_p.Arg848Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Asp244Asn clpC1_p.Asp244Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 15 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Asp326Ala clpC1_p.Asp326Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Asp326Asn clpC1_p.Asp326Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 443 9 434 34 439 4375 16383 0.00771149920616919 0.00534617862297411 0.0107595218761754 0.973903221971228 0.971380868310058 0.976259863712981 0.0718816067653276 0.050290682120927 0.0990012669770808 0.0203160270880361 0.00933084998360643 0.0382147227272244 0.0200892857142857 0.00922625406314035 0.0377920922019736 0.0776547728768927 0.0352351102621386 0.148965314738876 2.14507414669287e-32 12 1830 True True 0.29002121705174 0.197998577321846 0.41224639019606 0.00205291970802919 0.000939141859370595 0.00389348817205858 0.973903221971228 0.971380868310058 0.976259863712981 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 431 7 424 32 428 3754 15618 0.00845219228737453 0.00578827133991198 0.0119111956076972 0.973326685778387 0.970715015580959 0.975764806132608 0.0695652173913043 0.0480659032175176 0.0967887364047048 0.0162412993039443 0.00655413897711621 0.0331757169302117 0.0160919540229885 0.00649364821244198 0.0328732676007677 0.0686852263246248 0.0274338438007386 0.142945430251247 5.67962439407067e-30 12 1762 True True 1 1 1 0 0 0 0 0.311055123755844 0.209683260886487 0.446796051874666 0.00186120712576442 0.000748618950465531 0.00383101474713558 0.973326685778387 0.970715015580959 0.975764806132608 411 5) Not assoc w R New NotAwR yes 5 +Pyrazinamide clpC1 p.Asp443Ala clpC1_p.Asp443Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Asp474Gly clpC1_p.Asp474Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.23555131695149 1 1273 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 10.2590571436125 1 554.5 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 1 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Asp474His clpC1_p.Asp474His 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 0 9 0 10 4409 16812 0 0 0.000836320411980403 0.999405540363809 0.998907040193061 0.999714897863756 0 0 0.30849710781876 0 0 0.336267116879942 0 0 0.30849710781876 0 0 1.93269943246534 0.219086360959574 471.5 1830 False False 0 0 1.70188592764298 0 0 0.000836320411980403 0.999405540363809 0.998907040193061 0.999714897863756 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 0 10 3786 16036 0 0 0.000973872929872615 0.999376791723794 0.998854197426924 0.999701108243012 0 0 0.30849710781876 0 0 0.336267116879942 0 0 0.30849710781876 0 0 2.14701618016533 0.222583920922824 443.5 1762 False False 0 0 0 0 0 0 0 0 0 1.89058845367291 0 0 0.000973872929872615 0.999376791723794 0.998854197426924 0.999701108243012 NA 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Asp656Asn clpC1_p.Asp656Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.23555131695149 1 1273 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 10.2590571436125 1 554.5 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 5 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Asp656Gly clpC1_p.Asp656Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Asp699Ala clpC1_p.Asp699Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Asp753Val clpC1_p.Asp753Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Asp783His clpC1_p.Asp783His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Gln146Arg clpC1_p.Gln146Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Gln246Arg clpC1_p.Gln246Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Gln346His clpC1_p.Gln346His 1 missense_variant (see "Genomic_coordinates" sheet) 1 13 1 12 2 12 4407 16810 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.999286648436571 0.998754250286254 0.999631348241016 0.142857142857142 0.0177945154831915 0.428129160909698 0.0769230769230769 0.00194562849734675 0.360297435267877 0.0769230769230769 0.00194562849734675 0.360297435267877 0.317865516980561 0.0074376871918071 2.14952139571476 0.490172373124684 516 1830 False False 0.635731033961122 0.069080499493271 2.85729378651737 0.000226860254083484 5.74358785768897e-06 0.0012633291757201 0.999286648436571 0.998754250286254 0.999631348241016 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 13 1 12 2 12 3784 16034 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999252150068553 0.998694021458847 0.999613517219799 0.142857142857142 0.0177945154831915 0.428129160909698 0.0769230769230769 0.00194562849734675 0.360297435267877 0.0769230769230769 0.00194562849734675 0.360297435267877 0.353109584214235 0.00826158699287994 2.38818289837021 0.484103354151274 498 1762 False False 0 0 0 0 0 0 0 0.70621916842847 0.0767360307983807 3.17429704034148 0.000264200792602377 6.68896256519433e-06 0.00147114392376758 0.999252150068553 0.998694021458847 0.999613517219799 16 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Gln579Arg clpC1_p.Gln579Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Gln784Pro clpC1_p.Gln784Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 4 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Gln97Arg clpC1_p.Gln97Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Glu161Asp clpC1_p.Glu161Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Glu184Lys clpC1_p.Glu184Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.23555131695149 1 1273 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 10.2590571436125 1 554.5 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Glu240Lys clpC1_p.Glu240Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 4 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Glu327Val clpC1_p.Glu327Val 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Glu367Gln clpC1_p.Glu367Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 3 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Glu405Asp clpC1_p.Glu405Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1368 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Glu426Gly clpC1_p.Glu426Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Glu430Asp clpC1_p.Glu430Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 4 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Glu434Lys clpC1_p.Glu434Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Glu463Lys clpC1_p.Glu463Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Glu478Lys clpC1_p.Glu478Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Glu612Asp clpC1_p.Glu612Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Glu792Gly clpC1_p.Glu792Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Glu793Gln clpC1_p.Glu793Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1351 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1297 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Glu793Lys clpC1_p.Glu793Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 2 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Glu810Gly clpC1_p.Glu810Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 4408 16820 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999881108072762 0.999570588169705 0.999985601311719 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 148.481679985335 1 1273 1830 False False 1.9078947368421 0.0323314320919459 36.6634061310851 0 0 0.000836510060464794 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 3785 16044 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999875358344758 0.999549824781286 0.999984904960856 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 164.901569397629 1 927 1762 False False 0 0 0 0 0 0 0 2.11941875825627 0.0359146288488272 40.7195918479678 0 0 0.000974130102511011 0.999875358344758 0.999549824781286 0.999984904960856 2 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Gly159Arg clpC1_p.Gly159Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Gly471Asp clpC1_p.Gly471Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 4408 16821 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 3.81601633393829 0.0486026416232846 298.829108180248 0.372217803874758 506.5 1830 False False 3.81601633393829 0.0486026416232846 298.829108180248 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 3785 16045 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 4.23910171730515 0.0539892730999128 331.863925136224 0.345370788365398 466.5 1762 False False 0 0 0 0 0 0 0 4.23910171730515 0.0539892730999128 331.863925136224 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 3 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Gly58Ala clpC1_p.Gly58Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1355 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1300 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Gly686Ser clpC1_p.Gly686Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 4409 16817 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.16390782018879 0.590722354627394 560.5 1830 False False 0 0 4.16390782018879 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 3786 16041 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.62556638995023 0.590888399193514 509 1762 False False 0 0 0 0 0 0 0 0 0 4.62556638995023 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 3 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Gly813Asp clpC1_p.Gly813Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Gly822Ser clpC1_p.Gly822Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 2 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.His235Tyr clpC1_p.His235Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 4408 16821 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1364 1830 False False 3.81601633393829 0.0486026416232846 298.829108180248 0 0 0.000836510060464794 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 3785 16045 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1309 1762 False False 0 0 0 0 0 0 0 4.23910171730515 0.0539892730999128 331.863925136224 0 0 0.000974130102511011 0.999937679172379 0.999652820032955 0.999998422174497 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.His515Arg clpC1_p.His515Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.His631Asn clpC1_p.His631Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Ile139Val clpC1_p.Ile139Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Ile215Val clpC1_p.Ile215Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 11 0 11 2 13 4407 16809 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.999227202472952 0.998678855253688 0.999588455738321 0.133333333333333 0.0165759134400836 0.404602696603372 0 0 0.284914152918154 0 0 0.24705263800047 0 0 1.52042729234285 0.135362558215315 318 1830 False False 0.586793737236215 0.0642661236491552 2.5935672627138 0 0 0.000836699794980095 0.999227202472952 0.998678855253688 0.999588455738321 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 0 11 2 13 3784 16033 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999189829240932 0.998614981804171 0.999568549911067 0.133333333333333 0.0165759134400836 0.404602696603372 0 0 0.284914152918154 0 0 0.24705263800047 0 0 1.68906167744296 0.139286434755955 297 1762 False False 0 0 0 0 0 0 0 0.651853959993494 0.0713878431275329 2.88127358036689 0 0 0.000974387411009493 0.999189829240932 0.998614981804171 0.999568549911067 21 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Ile286Val clpC1_p.Ile286Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1369 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1313 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Ile320Val clpC1_p.Ile320Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1356 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1301 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Ile403Val clpC1_p.Ile403Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Ile412Leu clpC1_p.Ile412Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Ile412Ser clpC1_p.Ile412Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Ile550Val clpC1_p.Ile550Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Ile627Leu clpC1_p.Ile627Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1365 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1310 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Ile634Val clpC1_p.Ile634Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Ile673Val clpC1_p.Ile673Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1344 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1292 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Ile727Thr clpC1_p.Ile727Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1358 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1303 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Ile78Met clpC1_p.Ile78Met 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1359 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1304 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Leu204Val clpC1_p.Leu204Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Leu273Ile clpC1_p.Leu273Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Leu273Val clpC1_p.Leu273Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Leu402Val clpC1_p.Leu402Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1350 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1296 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Leu473Val clpC1_p.Leu473Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 4409 16818 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.78028251232769 0.586765606596145 543.5 1830 False False 0 0 5.78028251232769 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 3786 16042 0 0 0.000973872929872615 0.999750716689517 0.999361859844744 0.999932074644789 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.42109836734015 1 554.5 1762 False False 0 0 0 0 0 0 0 0 0 6.42109836734015 0 0 0.000973872929872615 0.999750716689517 0.999361859844744 0.999932074644789 8 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Leu566Val clpC1_p.Leu566Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Lys186Asn clpC1_p.Lys186Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Lys195Thr clpC1_p.Lys195Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Lys270Arg clpC1_p.Lys270Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 15 1 14 1 16 4408 16806 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999048864582094 0.998455873997109 0.999456249287664 0.0588235294117647 0.00148817439126663 0.28688939666722 0.0666666666666666 0.0016864302413527 0.319484566578303 0.0588235294117647 0.00148817439126663 0.28688939666722 0.27232953072336 0.00644266569268255 1.79092103544792 0.334587399239643 484 1830 False False 0.23828833938294 0.00568459580523725 1.5346868976765 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999048864582094 0.998455873997109 0.999456249287664 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 15 1 14 1 16 3785 16030 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.99900286675807 0.998381221815451 0.999429948179957 0.0588235294117647 0.00148817439126663 0.28688939666722 0.0666666666666666 0.0016864302413527 0.319484566578303 0.0588235294117647 0.00148817439126663 0.28688939666722 0.302509907529722 0.00715592591341935 1.98949921309265 0.330623900487774 459 1762 False False 0 0 0 0 0 0 0 0.264696169088507 0.00631387057219898 1.70493355197566 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.99900286675807 0.998381221815451 0.999429948179957 33 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Lys360Asn clpC1_p.Lys360Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Lys694Glu clpC1_p.Lys694Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Lys743Asn clpC1_p.Lys743Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Lys743Thr clpC1_p.Lys743Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Lys825Glu clpC1_p.Lys825Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Met379Ile clpC1_p.Met379Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1353 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1298 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 3 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Met379Leu clpC1_p.Met379Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 14 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Met693Ile clpC1_p.Met693Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Met734Ile clpC1_p.Met734Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 2 3 5 3 4404 16819 0.00113404400090723 0.000368320285107068 0.00264447958048867 0.999821662109142 0.999478910338162 0.999963220929399 0.625 0.244863216366551 0.914766585862746 0.4 0.0527449505263169 0.853367200365326 0.4 0.0527449505263169 0.853367200365326 2.54601877081441 0.21257466089721 22.2314909620828 0.278255518540261 481 1830 False False 6.36504692703602 1.23768373585682 41.0231847707768 0.000453926463912846 5.49773288296966e-05 0.00163876654014093 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 2 2 3784 16044 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999875358344758 0.999549824781286 0.999984904960856 0.5 0.067585986488543 0.932414013511457 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 2.11997885835095 0.0359241175697613 40.7303511527588 0.470274327371684 487.5 1762 False False 0 0 0 0 0 0 0 4.2399577167019 0.307210542317908 58.5302826936734 0.000264200792602377 6.68896256519433e-06 0.00147114392376758 0.999875358344758 0.999549824781286 0.999984904960856 3 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Phe342Leu clpC1_p.Phe342Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Phe595Cys clpC1_p.Phe595Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1352 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Phe657Val clpC1_p.Phe657Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Pro419Leu clpC1_p.Pro419Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Pro74Leu clpC1_p.Pro74Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Pro766Leu clpC1_p.Pro766Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 16 0 16 5 16 4404 16806 0.00113404400090723 0.000368320285107068 0.00264447958048867 0.999048864582094 0.998455873997109 0.999456249287664 0.238095238095238 0.0821758755930225 0.471659827654621 0 0 0.205907214207822 0 0 0.205907214207822 0 0 0.990000019888621 0.0563027851940333 289 1830 False False 1.19252384196185 0.341473465072992 3.40872269883258 0 0 0.000837269515297261 0.999048864582094 0.998455873997109 0.999456249287664 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 15 0 15 1 15 3785 16031 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999065187585691 0.998458637051574 0.999476701181019 0.0625 0.00158111172276588 0.302320738434531 0 0 0.218019360910534 0 0 0.218019360910534 0 0 1.18153383097366 0.0915982512415068 279 1762 False False 0 0 0 0 0 0 0 0.282360193747247 0.00670897970701436 1.8364726085417 0 0 0.000974130102511011 0.999065187585691 0.998458637051574 0.999476701181019 24 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Pro796Ala clpC1_p.Pro796Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 4409 16817 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.16390782018879 0.590722354627394 560.5 1830 False False 0 0 4.16390782018879 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 3786 16041 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.62556638995023 0.590888399193514 509 1762 False False 0 0 0 0 0 0 0 0 0 4.62556638995023 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 NA 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Pro796Gln clpC1_p.Pro796Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Pro796Leu clpC1_p.Pro796Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 176 5 171 17 179 4392 16643 0.00385574960308459 0.00224767150840848 0.00616627368860949 0.989359172512186 0.987691391586537 0.990854339199259 0.086734693877551 0.0513391845468138 0.135238480454669 0.0284090909090909 0.00928737656489109 0.0650491568782727 0.0271739130434782 0.00888092660553444 0.0622725361034949 0.110800871334377 0.0355330904685397 0.26388485643891 4.13491873490979e-12 NA NA False True 0.359886182088306 0.204861606723228 0.593449066620942 0.00113713895838071 0.000369325752165199 0.00265169124426511 0.989359172512186 0.987691391586537 0.990854339199259 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 176 5 171 17 178 3769 15868 0.00449022715266772 0.00261783253916465 0.00717958501762183 0.988906892683534 0.98716345487917 0.990469523163643 0.0871794871794871 0.0516068008607995 0.135913217523566 0.0284090909090909 0.00928737656489109 0.0650491568782727 0.0273224043715847 0.00892977655028724 0.0626065841288584 0.123103371766286 0.0394425259199797 0.293244049740526 1.1140687332726e-10 NA NA False True 0 1 1 0 0 1 0 0.402091574971455 0.228809181417297 0.663279074339095 0.00132485426603073 0.000430312090959328 0.00308903725725986 0.988906892683534 0.98716345487917 0.990469523163643 429 Not assoc w R 5) Not assoc w R No change yes 1 +Pyrazinamide clpC1 p.Pro79Thr clpC1_p.Pro79Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1346 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Thr179Met clpC1_p.Thr179Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 2 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Thr208Ile clpC1_p.Thr208Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 4409 16817 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 5.77993884793644 0.58676144625344 535 1830 False False 0 0 4.16390782018879 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 5 3786 16041 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 6.42069813886719 1 927 1762 False False 0 0 0 0 0 0 0 0 0 4.62556638995023 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 3 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Thr249Met clpC1_p.Thr249Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Thr278Ser clpC1_p.Thr278Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Thr654Met clpC1_p.Thr654Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Thr819Ser clpC1_p.Thr819Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1362 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1307 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Tyr248Cys clpC1_p.Tyr248Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Tyr690Ser clpC1_p.Tyr690Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Val170Leu clpC1_p.Val170Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Val345Leu clpC1_p.Val345Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 4408 16820 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999881108072762 0.999570588169705 0.999985601311719 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 148.481679985335 1 1273 1830 False False 1.9078947368421 0.0323314320919459 36.6634061310851 0 0 0.000836510060464794 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 3785 16044 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999875358344758 0.999549824781286 0.999984904960856 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 164.901569397629 1 927 1762 False False 0 0 0 0 0 0 0 2.11941875825627 0.0359146288488272 40.7195918479678 0 0 0.000974130102511011 0.999875358344758 0.999549824781286 0.999984904960856 5 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Val44Phe clpC1_p.Val44Phe 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1347 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1294 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Val525Phe clpC1_p.Val525Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Val602Ile clpC1_p.Val602Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Val63Ala clpC1_p.Val63Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1257 139 1118 243 1275 4166 15547 0.0551145384440916 0.0485617245863888 0.0622641741566369 0.924206396385685 0.920103332615672 0.928162065416155 0.160079051383399 0.141975067428183 0.179508402676916 0.110580747812251 0.0937723530947169 0.129234197872142 0.0983026874115983 0.083278013810833 0.115019152571841 0.463981142170582 0.384919623893467 0.55587660470848 6.31825047495418e-20 NA NA False True 0.711251870887577 0.614898072630061 0.820119970726522 0.0322880371660859 0.0272110284156505 0.0380118448899889 0.924206396385685 0.920103332615672 0.928162065416155 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 1250 139 1111 241 1261 3545 14785 0.0636555731642894 0.0560860566792279 0.0719068678508896 0.921413436370435 0.917141852632106 0.925531504730124 0.160452729693741 0.14223630817554 0.180007283197143 0.1112 0.0943022090860798 0.129950234770832 0.0992857142857142 0.0841174444152125 0.116158521261933 0.521802109689107 0.432616080746203 0.625487967238647 3.10292635609345e-14 NA NA False True 0 0 0 0 0 1 0 0.79708942127333 0.688240532445619 0.920226192751894 0.0377307274701411 0.0318113254200156 0.0443971779397485 0.921413436370435 0.917141852632106 0.925531504730124 3130 Not assoc w R Previous WHO guidance 4) Not assoc w R - Interim DOWN from NotAwR to NotAwRI yes Prev. WHO 3 +Pyrazinamide clpC1 p.Val677Ile clpC1_p.Val677Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide clpC1 p.Val718Ile clpC1_p.Val718Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1357 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1302 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 2 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Val794Phe clpC1_p.Val794Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide clpC1 p.Val817Met clpC1_p.Val817Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide panD c.105C>G panD_c.105C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide panD c.-10G>A panD_c.-10G>A 1 upstream_gene_variant 4044291 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide panD c.123C>A panD_c.123C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 16 4409 16806 0 0 0.000836320411980403 0.999048864582094 0.998455873997109 0.999456249287664 0 0 0.205907214207822 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.988876825211935 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 16 3786 16030 0 0 0.000973872929872615 0.99900286675807 0.998381221815451 0.999429948179957 0 0 0.205907214207822 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.0984958938859 NA NA NA NA NA NA 15 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide panD c.126A>G panD_c.126A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide panD c.144T>C panD_c.144T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide panD c.-1838T>G panD_c.-1838T>G 1 upstream_gene_variant 4046119 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide panD c.-1853T>C panD_c.-1853T>C 1 upstream_gene_variant 4046134 1 4 0 4 0 4 4409 16818 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.78028251232769 0.586765606596145 543.5 1830 False False 0 0 5.78028251232769 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 3786 16042 0 0 0.000973872929872615 0.999750716689517 0.999361859844744 0.999932074644789 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.42109836734015 1 554.5 1762 False False 0 0 0 0 0 0 0 0 0 6.42109836734015 0 0 0.000973872929872615 0.999750716689517 0.999361859844744 0.999932074644789 10 3) Uncertain significance No change no 1 +Pyrazinamide panD c.-1854C>T panD_c.-1854C>T 1 upstream_gene_variant 4046135 1 15 0 15 1 17 4408 16805 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.998989418618475 0.998382452772912 0.999411192380357 0.0555555555555555 0.00140555616736942 0.272943599673368 0 0 0.218019360910534 0 0 0.195064322969093 0 0 1.06343650442543 0.0524319336159559 288 1830 False False 0.224258033521938 0.00536846248346029 1.43203726249083 0 0 0.000836510060464794 0.998989418618475 0.998382452772912 0.999411192380357 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 15 0 15 1 17 3785 16029 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.99894054593045 0.998304251550396 0.999382711664247 0.0555555555555555 0.00140555616736942 0.272943599673368 0 0 0.218019360910534 0 0 0.195064322969093 0 0 1.18138669774342 0.0916051245616172 280 1762 False False 0 0 0 0 0 0 0 0.249110264977853 0.00596269606976058 1.59084611373257 0 0 0.000974130102511011 0.99894054593045 0.998304251550396 0.999382711664247 52 3) Uncertain significance No change no 1 +Pyrazinamide panD c.-1855C>A panD_c.-1855C>A 1 upstream_gene_variant 4046136 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide panD c.-1856A>G panD_c.-1856A>G 1 upstream_gene_variant 4046137 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance No change no 1 +Pyrazinamide panD c.-1858A>C panD_c.-1858A>C 1 upstream_gene_variant 4046139 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide panD c.-1864A>G panD_c.-1864A>G 1 upstream_gene_variant 4046145 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide panD c.-1874A>C panD_c.-1874A>C 1 upstream_gene_variant 4046155 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide panD c.-1880C>A panD_c.-1880C>A 1 upstream_gene_variant 4046161 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide panD c.-1880C>T panD_c.-1880C>T 1 upstream_gene_variant 4046161 1 8 0 8 0 8 4409 16814 0 0 0.000836320411980403 0.999524432291047 0.999063158238902 0.999794661972981 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 2.2350715489366 0.218829042398071 461.5 1830 False False 0 0 2.2350715489366 0 0 0.000836320411980403 0.999524432291047 0.999063158238902 0.999794661972981 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 0 8 3786 16038 0 0 0.000973872929872615 0.999501433379035 0.999017862631239 0.999784730530787 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 2.48286669292342 0.36696353836705 478 1762 False False 0 0 0 0 0 0 0 0 0 2.48286669292342 0 0 0.000973872929872615 0.999501433379035 0.999017862631239 0.999784730530787 3 3) Uncertain significance No change no 1 +Pyrazinamide panD c.-1882G>A panD_c.-1882G>A 1 upstream_gene_variant 4046163 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide panD c.-1884C>A panD_c.-1884C>A 1 upstream_gene_variant 4046165 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide panD c.-1889G>T panD_c.-1889G>T 1 upstream_gene_variant 4046170 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide panD c.-1891C>A panD_c.-1891C>A 1 upstream_gene_variant 4046172 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide panD c.-1892C>T panD_c.-1892C>T 1 upstream_gene_variant 4046173 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide panD c.-1894G>A panD_c.-1894G>A 1 upstream_gene_variant 4046175 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide panD c.-1895C>A panD_c.-1895C>A 1 upstream_gene_variant 4046176 1 7 1 6 1 6 4408 16816 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999643324218285 0.999223829869625 0.999869095386533 0.142857142857142 0.00361029686190058 0.578723197043195 0.142857142857142 0.00361029686190058 0.578723197043195 0.142857142857142 0.00361029686190058 0.578723197043195 0.635813672111312 0.0138232628839914 5.24325822004213 1 1273 1830 False False 0.635813672111312 0.0138232628839914 5.24325822004213 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999643324218285 0.999223829869625 0.999869095386533 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 1 6 1 6 3785 16040 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999626075034276 0.999186301793093 0.999862764161372 0.142857142857142 0.00361029686190058 0.578723197043195 0.142857142857142 0.00361029686190058 0.578723197043195 0.142857142857142 0.00361029686190058 0.578723197043195 0.706296785557023 0.0153546142757778 5.82369259713769 1 927 1762 False False 0 0 0 0 0 0 0 0.706296785557023 0.0153546142757778 5.82369259713769 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999626075034276 0.999186301793093 0.999862764161372 54 3) Uncertain significance No change no 1 +Pyrazinamide panD c.-1901_-1896delGGTGAC panD_c.-1901_-1896delGGTGAC 1 upstream_gene_variant 4046176 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide panD c.-1904C>T panD_c.-1904C>T 1 upstream_gene_variant 4046185 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 2 3) Uncertain significance No change no 1 +Pyrazinamide panD c.-1918A>C panD_c.-1918A>C 1 upstream_gene_variant 4046199 1 9 0 9 0 9 4409 16813 0 0 0.000836320411980403 0.999464986327428 0.998984621445092 0.999755329427402 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.336267116879942 0 0 1.9328143827158 0.219086249473785 468 1830 False False 0 0 1.9328143827158 0 0 0.000836320411980403 0.999464986327428 0.998984621445092 0.999755329427402 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 0 9 3786 16037 0 0 0.000973872929872615 0.999439112551414 0.998935529133907 0.999743495490327 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.336267116879942 0 0 2.14715011586227 0.222588131410409 446.5 1762 False False 0 0 0 0 0 0 0 0 0 2.14715011586227 0 0 0.000973872929872615 0.999439112551414 0.998935529133907 0.999743495490327 NA 3) Uncertain significance No change no 1 +Pyrazinamide panD c.-1920G>A panD_c.-1920G>A 1 upstream_gene_variant 4046201 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide panD c.-1921T>A panD_c.-1921T>A 1 upstream_gene_variant 4046202 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 8 3) Uncertain significance No change no 1 +Pyrazinamide panD c.-1921T>G panD_c.-1921T>G 1 upstream_gene_variant 4046202 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide panD c.-1922G>A panD_c.-1922G>A 1 upstream_gene_variant 4046203 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide panD c.-1923C>T panD_c.-1923C>T 1 upstream_gene_variant 4046204 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance No change no 1 +Pyrazinamide panD c.-1929T>C panD_c.-1929T>C 1 upstream_gene_variant 4046210 1 9 0 9 0 9 4409 16813 0 0 0.000836320411980403 0.999464986327428 0.998984621445092 0.999755329427402 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.336267116879942 0 0 1.9328143827158 0.219086249473785 468 1830 False False 0 0 1.9328143827158 0 0 0.000836320411980403 0.999464986327428 0.998984621445092 0.999755329427402 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 0 9 3786 16037 0 0 0.000973872929872615 0.999439112551414 0.998935529133907 0.999743495490327 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.336267116879942 0 0 2.14715011586227 0.222588131410409 446.5 1762 False False 0 0 0 0 0 0 0 0 0 2.14715011586227 0 0 0.000973872929872615 0.999439112551414 0.998935529133907 0.999743495490327 1 3) Uncertain significance No change no 1 +Pyrazinamide panD c.192C>T panD_c.192C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide panD c.-1937C>T panD_c.-1937C>T 1 upstream_gene_variant 4046218 1 61 0 61 166 82 4243 16740 0.0376502608301202 0.0322264371060261 0.0436969701365745 0.995125430983236 0.993952935301764 0.996121289029362 0.669354838709677 0.607023821798892 0.727580174683425 0 0 0.0586812239322925 0 0 0.0439894541868423 0 0 0.246093347482444 2.49379227934494e-06 NA NA False True 7.98687077137092 6.07940638144847 10.5584536079406 0 0 0.000869025773320196 0.995125430983236 0.993952935301764 0.996121289029362 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 61 0 61 164 82 3622 15964 0.0433174854727945 0.0370558632611871 0.0502957265417048 0.994889692135111 0.993660674112286 0.995933618329083 0.666666666666666 0.603982838172543 0.725276985260958 0 0 0.0586812239322925 0 0 0.0439894541868423 0 0 0.274959870280811 6.93242693458675e-06 NA NA False True 0 1 1 0 0 1 0 8.81501932633903 6.70328881414581 11.6644581947403 0 0 0.001017946326551 0.994889692135111 0.993660674112286 0.995933618329083 132 Not assoc w R 5) Not assoc w R No change yes 1 +Pyrazinamide panD c.-1937delC panD_c.-1937delC 1 upstream_gene_variant 4046217 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 8 3) Uncertain significance No change no 1 +Pyrazinamide panD c.-1938C>G panD_c.-1938C>G 1 upstream_gene_variant 4046219 1 5 1 4 2 5 4407 16817 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.999702770181904 0.999306502227134 0.999903483469113 0.285714285714285 0.0366925661760855 0.709579136262657 0.2 0.00505076337946806 0.716417936118089 0.166666666666666 0.00421074451448947 0.641234578997674 0.953993646471522 0.0193670232866612 9.64102379509151 1 1273 1830 False False 1.52638983435443 0.145279490817154 9.32731563324253 0.000226860254083484 5.74358785768897e-06 0.0012633291757201 0.999702770181904 0.999306502227134 0.999903483469113 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 1 4 2 5 3784 16041 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999688395861897 0.99927297097682 0.999898815491092 0.285714285714285 0.0366925661760855 0.709579136262657 0.2 0.00505076337946806 0.716417936118089 0.166666666666666 0.00421074451448947 0.641234578997674 1.05979122621564 0.0215140398430192 10.7165752013793 1 927 1762 False False 0 0 0 0 0 0 0 1.69566596194503 0.161390749261539 10.3624974670859 0.000264200792602377 6.68896256519433e-06 0.00147114392376758 0.999688395861897 0.99927297097682 0.999898815491092 8 3) Uncertain significance No change no 1 +Pyrazinamide panD c.-1940C>T panD_c.-1940C>T 1 upstream_gene_variant 4046221 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 1 3) Uncertain significance No change no 1 +Pyrazinamide panD c.-1946G>C panD_c.-1946G>C 1 upstream_gene_variant 4046227 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide panD c.-1947A>C panD_c.-1947A>C 1 upstream_gene_variant 4046228 1 2 1 1 1 1 4408 16821 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 3.81601633393829 0.0486026416232846 298.829108180248 0.372217803874758 506.5 1830 False False 3.81601633393829 0.0486026416232846 298.829108180248 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 3785 16045 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 4.23910171730515 0.0539892730999128 331.863925136224 0.345370788365398 466.5 1762 False False 0 0 0 0 0 0 0 4.23910171730515 0.0539892730999128 331.863925136224 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance No change no 1 +Pyrazinamide panD c.1A>C panD_c.1A>C 1 initiator_codon_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide panD c.219T>C panD_c.219T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide panD c.21G>A panD_c.21G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 4409 16818 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.78028251232769 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 3786 16042 0 0 0.000973872929872615 0.999750716689517 0.999361859844744 0.999932074644789 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.42109836734015 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide panD c.231C>T panD_c.231C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0978301145652783 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide panD c.-23C>A panD_c.-23C>A 1 upstream_gene_variant 4044304 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide panD c.-24C>T panD_c.-24C>T 1 upstream_gene_variant 4044305 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide panD c.259C>T panD_c.259C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 10 78 4399 16744 0.00226808800181447 0.00108815543692413 0.00416712622349087 0.995363214837712 0.994216412586571 0.996333139628215 0.113636363636363 0.0558579759508812 0.199067856713038 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.487989694627566 0.225009734346234 0.947084985630897 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 10 78 3776 15968 0.00264131008980454 0.00126731492930415 0.00485208155788738 0.995138975445594 0.993936881711126 0.996155721721284 0.113636363636363 0.0558579759508812 0.199067856713038 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 0 0.542155584528465 0.249926400456278 1.05239304040143 NA NA NA NA NA NA 171 5) Not assoc w R Now listed Silent mutation no 0 +Pyrazinamide panD c.-26A>G panD_c.-26A>G 1 upstream_gene_variant 4044307 1 14 0 14 0 14 4409 16808 0 0 0.000836320411980403 0.999167756509333 0.998604030697473 0.99954493241661 0 0 0.231635761650116 0 0 0.231635761650116 0 0 0.231635761650116 0 0 1.14979365621044 0.0900355704642355 299 1830 False False 0 0 1.14979365621044 0 0 0.000836320411980403 0.999167756509333 0.998604030697473 0.99954493241661 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 12 0 12 0 12 3786 16034 0 0 0.000973872929872615 0.999252150068553 0.998694021458847 0.999613517219799 0 0 0.264648469397051 0 0 0.264648469397051 0 0 0.264648469397051 0 0 1.52501633506388 0.139670104028204 299 1762 False False 0 0 0 0 0 0 0 0 0 1.52501633506388 0 0 0.000973872929872615 0.999252150068553 0.998694021458847 0.999613517219799 8 3) Uncertain significance New Uncertain no 0 +Pyrazinamide panD c.-31G>A panD_c.-31G>A 1 upstream_gene_variant 4044312 1 3 0 3 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.23555131695149 1 1273 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 10.2590571436125 1 554.5 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide panD c.336C>T panD_c.336C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide panD c.348C>T panD_c.348C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide panD c.-34A>G panD_c.-34A>G 1 upstream_gene_variant 4044315 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide panD c.354C>T panD_c.354C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide panD c.357C>T panD_c.357C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide panD c.36C>A panD_c.36C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide panD c.-38G>A panD_c.-38G>A 1 upstream_gene_variant 4044319 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide panD c.-39C>A panD_c.-39C>A 1 upstream_gene_variant 4044320 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide panD c.39C>G panD_c.39C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide panD c.-3C>G panD_c.-3C>G 1 upstream_gene_variant 4044284 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide panD c.405G>C panD_c.405G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide panD c.-43C>A panD_c.-43C>A 1 upstream_gene_variant 4044324 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide panD c.4T>C panD_c.4T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide panD c.63C>T panD_c.63C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide panD c.6A>G panD_c.6A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide panD c.-7G>A panD_c.-7G>A 1 upstream_gene_variant 4044288 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide panD LoF panD_LoF 1 LoF (see "Genomic_coordinates" sheet) 1 21 6 15 6 16 4403 16806 0.00136085280108868 0.000499567554195151 0.00295963286153356 0.999048864582094 0.998455873997109 0.999456249287664 0.272727272727272 0.107289248370397 0.502221201266349 0.285714285714285 0.11280940392194 0.521751118247113 0.272727272727272 0.107289248370397 0.502221201266349 1.52677719736543 0.485012084782161 4.16702666514564 0.416954947578295 515 1830 False False 1.43135362253009 0.458437727504936 3.85378515963845 0.00136085280108868 0.000499567554195151 0.00295963286153356 0.999048864582094 0.998455873997109 0.999456249287664 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 21 6 15 6 16 3780 16030 0.00158478605388272 0.000581803608073282 0.0034461969631646 0.99900286675807 0.998381221815451 0.999429948179957 0.272727272727272 0.107289248370397 0.502221201266349 0.285714285714285 0.11280940392194 0.521751118247113 0.272727272727272 0.107289248370397 0.502221201266349 1.69629629629629 0.538840979911038 4.63017162666833 0.267813786934339 457 1762 False False 0 0 0 0 0 0 0 1.59027777777777 0.509308579943828 4.2820174488542 0.00158478605388272 0.000581803608073282 0.0034461969631646 0.99900286675807 0.998381221815451 0.999429948179957 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide panD p.Ala122Thr panD_p.Ala122Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide panD p.Ala96Thr panD_p.Ala96Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.23555131695149 1 1273 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 10.2590571436125 1 554.5 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 5 3) Uncertain significance No change no 1 +Pyrazinamide panD p.Ala96Val panD_p.Ala96Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide panD p.Ala98Thr panD_p.Ala98Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide panD p.Arg104Gln panD_p.Arg104Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide panD p.Arg135fs panD_p.Arg135fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1341 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1289 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 3 3) Uncertain significance No change no 1 +Pyrazinamide panD p.Arg135Gly panD_p.Arg135Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide panD p.Arg97Trp panD_p.Arg97Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 12 0 12 0 12 4409 16810 0 0 0.000836320411980403 0.999286648436571 0.998754250286254 0.999631348241016 0 0 0.264648469397051 0 0 0.264648469397051 0 0 0.264648469397051 0 0 1.37280707722974 0.144295971508092 320.5 1830 False False 0 0 1.37280707722974 0 0 0.000836320411980403 0.999286648436571 0.998754250286254 0.999631348241016 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 12 0 12 0 12 3786 16034 0 0 0.000973872929872615 0.999252150068553 0.998694021458847 0.999613517219799 0 0 0.264648469397051 0 0 0.264648469397051 0 0 0.264648469397051 0 0 1.52501633506388 0.139670104028204 299 1762 False False 0 0 0 0 0 0 0 0 0 1.52501633506388 0 0 0.000973872929872615 0.999252150068553 0.998694021458847 0.999613517219799 2 3) Uncertain significance No change no 1 +Pyrazinamide panD p.Arg99Gly panD_p.Arg99Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide panD p.Asp109Asn panD_p.Asp109Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 1 4406 16821 0.000680426400544341 0.000140342268876931 0.00198719451371054 0.99994055403638 0.999668833292177 0.99999849495964 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 1342 1830 False False 11.4532455742169 0.919224933680734 599.12689591493 0 0 0.000836889615584862 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 1 3783 16045 0.000792393026941363 0.000163440311798119 0.00231394549068866 0.999937679172379 0.999652820032955 0.999998422174497 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 1290 1762 False False 0 0 0 0 0 0 0 12.7240285487708 1.02115021686679 665.307410149575 0 0 0.000974644855475749 0.999937679172379 0.999652820032955 0.999998422174497 23 3) Uncertain significance No change no 1 +Pyrazinamide panD p.Asp116Gly panD_p.Asp116Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 4409 16817 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.16390782018879 0.590722354627394 560.5 1830 False False 0 0 4.16390782018879 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 3786 16041 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.62556638995023 0.590888399193514 509 1762 False False 0 0 0 0 0 0 0 0 0 4.62556638995023 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 2 3) Uncertain significance No change no 1 +Pyrazinamide panD p.Asp31Glu panD_p.Asp31Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1339 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1287 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance No change no 1 +Pyrazinamide panD p.Asp34Gly panD_p.Asp34Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1337 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1285 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide panD p.Asp37Glu panD_p.Asp37Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide panD p.Asp50Asn panD_p.Asp50Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 16 1 15 1 15 4408 16807 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999108310545714 0.998529719637006 0.999500845014484 0.0625 0.00158111172276588 0.302320738434531 0.0625 0.00158111172276588 0.302320738434531 0.0625 0.00158111172276588 0.302320738434531 0.254189352692075 0.00604027986577356 1.65312024234863 0.220087765400585 473 1830 False False 0.254189352692075 0.00604027986577356 1.65312024234863 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999108310545714 0.998529719637006 0.999500845014484 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 16 1 15 1 15 3785 16031 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999065187585691 0.998458637051574 0.999476701181019 0.0625 0.00158111172276588 0.302320738434531 0.0625 0.00158111172276588 0.302320738434531 0.0625 0.00158111172276588 0.302320738434531 0.282360193747247 0.00670897970701436 1.8364726085417 0.336124278640843 460 1762 False False 0 0 0 0 0 0 0 0.282360193747247 0.00670897970701436 1.8364726085417 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999065187585691 0.998458637051574 0.999476701181019 7 3) Uncertain significance No change no 1 +Pyrazinamide panD p.Asp50Glu panD_p.Asp50Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide panD p.Gln43Arg panD_p.Gln43Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide panD p.Gly118fs panD_p.Gly118fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide panD p.Gly137Val panD_p.Gly137Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide panD p.Gly139Arg panD_p.Gly139Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide panD p.Gly139* panD_p.Gly139* 1 stop_gained (see "Genomic_coordinates" sheet) 1 19 5 14 5 14 4404 16808 0.00113404400090723 0.000368320285107068 0.00264447958048867 0.999167756509333 0.998604030697473 0.99954493241661 0.263157894736842 0.0914657849076665 0.512029345345872 0.263157894736842 0.0914657849076665 0.512029345345872 0.263157894736842 0.0914657849076665 0.512029345345872 1.36304658103023 0.383992344704672 4.00779710461315 0.570946558987673 531 1830 False False 1.36304658103023 0.383992344704672 4.00779710461315 0.00113404400090723 0.000368320285107068 0.00264447958048867 0.999167756509333 0.998604030697473 0.99954493241661 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 19 5 14 5 14 3781 16032 0.00132065504490227 0.000428947757354115 0.0030792549559865 0.999127508413311 0.998536540247476 0.999522921242413 0.263157894736842 0.0914657849076665 0.512029345345872 0.263157894736842 0.0914657849076665 0.512029345345872 0.263157894736842 0.0914657849076665 0.512029345345872 1.51433861034495 0.426595435335435 4.45254439260979 0.38776674566576 483 1762 False False 0 0 0 0 0 0 0 1.51433861034495 0.426595435335435 4.45254439260979 0.00132065504490227 0.000428947757354115 0.0030792549559865 0.999127508413311 0.998536540247476 0.999522921242413 35 3) Uncertain significance No change no 1 +Pyrazinamide panD p.Ile115Thr panD_p.Ile115Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 11 3 8 4 8 4405 16814 0.000907235200725788 0.000247244623732042 0.00232123869101376 0.999524432291047 0.999063158238902 0.999794661972981 0.333333333333333 0.0992460911495833 0.651124493581186 0.272727272727272 0.0602177341729066 0.609742559572421 0.272727272727272 0.0602177341729066 0.609742559572421 1.43138479001135 0.24447308824839 5.96681088375311 0.707993998111067 573 1830 False False 1.90851305334846 0.420353979309515 7.12756261618215 0.000680580762250453 0.000140374111950171 0.0019876450342228 0.999524432291047 0.999063158238902 0.999794661972981 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 3 8 4 8 3782 16038 0.00105652403592181 0.000287939890647285 0.00270289202199999 0.999501433379035 0.999017862631239 0.999784730530787 0.333333333333333 0.0992460911495833 0.651124493581186 0.272727272727272 0.0602177341729066 0.609742559572421 0.272727272727272 0.0602177341729066 0.609742559572421 1.59023003701745 0.271588079765872 6.62874135976649 0.449530550036255 484 1762 False False 0 0 0 0 0 0 0 2.12030671602326 0.466937552398573 7.91899912011279 0.000792602377807133 0.000163483500741026 0.00231455637111671 0.999501433379035 0.999017862631239 0.999784730530787 3 3) Uncertain significance No change no 1 +Pyrazinamide panD p.Ile49Val panD_p.Ile49Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 0 8 4409 16814 0 0 0.000836320411980403 0.999524432291047 0.999063158238902 0.999794661972981 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 2.2350715489366 0.218829042398071 461.5 1830 False False 0 0 2.2350715489366 0 0 0.000836320411980403 0.999524432291047 0.999063158238902 0.999794661972981 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 0 8 3786 16038 0 0 0.000973872929872615 0.999501433379035 0.999017862631239 0.999784730530787 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 2.48286669292342 0.36696353836705 478 1762 False False 0 0 0 0 0 0 0 0 0 2.48286669292342 0 0 0.000973872929872615 0.999501433379035 0.999017862631239 0.999784730530787 12 3) Uncertain significance No change no 1 +Pyrazinamide panD p.Ile60Thr panD_p.Ile60Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1343 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1291 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide panD p.Leu132Pro panD_p.Leu132Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide panD p.Leu136fs panD_p.Leu136fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide panD p.Met117Thr panD_p.Met117Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 3 0 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 1.57702975056642 Inf 0.00895106588186537 214 1830 False False Inf 1.57702975056642 Inf 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 3 0 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 1.75196919627044 Inf 0.00695286470680484 189.5 1762 False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 5 3) Uncertain significance No change no 1 +Pyrazinamide panD p.Met5Ile panD_p.Met5Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide panD p.Pro134Ala panD_p.Pro134Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 3 3) Uncertain significance New Uncertain no 0 +Pyrazinamide panD p.Pro134Ser panD_p.Pro134Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 1 8 1 8 4408 16814 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999524432291047 0.999063158238902 0.999794661972981 0.111111111111111 0.00280913674659921 0.482496514917337 0.111111111111111 0.00280913674659921 0.482496514917337 0.111111111111111 0.00280913674659921 0.482496514917337 0.476803539019963 0.0107465349444348 3.55811644738743 0.695569747644176 572 1830 False False 0.476803539019963 0.0107465349444348 3.55811644738743 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999524432291047 0.999063158238902 0.999794661972981 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 1 7 1 7 3785 16039 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999563754206656 0.999101374817905 0.99982458915172 0.125 0.0031597235312519 0.526509670875206 0.125 0.0031597235312519 0.526509670875206 0.125 0.0031597235312519 0.526509670875206 0.605359501792791 0.0134317907447528 4.71432113745169 1 927 1762 False False 0 0 0 0 0 0 0 0.605359501792791 0.0134317907447528 4.71432113745169 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999563754206656 0.999101374817905 0.99982458915172 12 3) Uncertain significance No change no 1 +Pyrazinamide panD p.Pro81Leu panD_p.Pro81Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide panD p.Ser8Ala panD_p.Ser8Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1338 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1286 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide panD p.Thr100Pro panD_p.Thr100Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide panD p.Thr14Met panD_p.Thr14Met 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1340 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1288 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide panD p.Thr4Ala panD_p.Thr4Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 3 3) Uncertain significance No change no 1 +Pyrazinamide panD p.Val15Ala panD_p.Val15Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide pncA c.103C>T pncA_c.103C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide pncA c.105G>A pncA_c.105G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.23555131695149 NA NA NA NA NA NA 3) Uncertain significance 4) Not assoc w R - Interim WHO 4) Not assoc w R - interim 1 NA NA NA 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.2590571436125 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide pncA c.-10delT pncA_c.-10delT 1 upstream_gene_variant 2289250 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA c.-10T>C pncA_c.-10T>C 1 upstream_gene_variant 2289251 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 2 3) Uncertain significance No change no 1 +Pyrazinamide pncA c.114G>C pncA_c.114G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 4409 16817 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.16390782018879 NA NA NA NA NA NA 3) Uncertain significance 4) Not assoc w R - Interim WHO 4) Not assoc w R - interim 1 NA NA NA 0 5 3786 16041 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.62556638995023 NA NA NA NA NA NA 14 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide pncA c.-11A>C pncA_c.-11A>C 1 upstream_gene_variant 2289252 1 23 23 0 24 0 4385 16822 0.00544341120435472 0.00349071725023238 0.0080886043215741 1 0.999780735048249 1 1 0.857526402277474 1 1 0.851814871084775 1 1 0.851814871084775 1 Inf 22.037183527256 Inf 1.89633402076352e-16 34 1830 True False Inf 23.073844353815 Inf 0.00521778584392014 0.00331041786096272 0.00781901413920693 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 21 21 0 22 0 3764 16046 0.00581088219756999 0.00364512527326634 0.00878460174058437 1 0.999770132403032 1 1 0.845627487184425 1 1 0.83890238478092 1 1 0.83890238478092 1 Inf 22.1821221008229 Inf 7.50944733208546e-16 28 1762 True False 0 0 0 0 0 0 0 Inf 23.3393798673521 Inf 0.00554821664464993 0.0034376162554837 0.00846859773627595 1 0.999770132403032 1 35 Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA c.-11A>G pncA_c.-11A>G 1 upstream_gene_variant 2289252 1 150 140 10 141 10 4268 16812 0.031980040825584 0.026985157588128 0.0376067602563513 0.999405540363809 0.998907040193061 0.999714897863756 0.933774834437086 0.881582895788499 0.967788151575084 0.933333333333333 0.880816022933074 0.967570271841323 0.933333333333333 0.880816022933074 0.967570271841323 55.1471415182755 29.0478296170465 117.463467767236 5.55978253116082e-83 3 1830 True False 55.5410496719775 29.307683623723 118.297335260481 0.0317604355716878 0.0267824355685589 0.0373707713935184 0.999405540363809 0.998907040193061 0.999714897863756 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 131 125 6 126 6 3660 16040 0.0332805071315372 0.0277976873594747 0.0394982263940295 0.999626075034276 0.999186301793093 0.999862764161372 0.954545454545454 0.903690560391639 0.983138780196772 0.954198473282442 0.902975423082724 0.983008655486213 0.954198473282442 0.902975423082724 0.983008655486213 91.3023679417122 40.7239448925521 253.458777247987 4.22871367654036e-82 3 1762 True False 0 0 0 0 0 0 0 92.0327868852459 41.0611342400681 255.401917815485 0.0330250990752972 0.0275630054831531 0.0392227705689528 0.999626075034276 0.999186301793093 0.999862764161372 382 Assoc w R Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA c.-11A>T pncA_c.-11A>T 1 upstream_gene_variant 2289252 1 4 4 0 4 0 4405 16822 0.000907235200725788 0.000247244623732042 0.00232123869101376 1 0.999780735048249 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 2.51959224712996 Inf 0.00185784794966548 174 1830 True False Inf 2.51959224712996 Inf 0.000907235200725788 0.000247244623732042 0.00232123869101376 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 4 4 0 4 0 3782 16046 0.00105652403592181 0.000287939890647285 0.00270289202199999 1 0.999770132403032 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 2.79918348098377 Inf 0.0013264757267559 157.5 1762 True False 0 0 0 0 0 0 0 Inf 2.79918348098377 Inf 0.00105652403592181 0.000287939890647285 0.00270289202199999 1 0.999770132403032 1 2 Assoc w RI 2) Assoc w R - Interim No change yes 1 +Pyrazinamide pncA c.-12T>C pncA_c.-12T>C 1 upstream_gene_variant 2289253 1 8 7 1 7 1 4402 16821 0.00158766160127012 0.000638553061192671 0.00326843667440656 0.99994055403638 0.999668833292177 0.99999849495964 0.875 0.473490329124793 0.996840276468748 0.875 0.473490329124793 0.996840276468748 0.875 0.473490329124793 0.996840276468748 26.7485233984552 3.43432279452703 1197.87100642049 0.000108659178644894 138 1830 True False 26.7485233984552 3.43432279452703 1197.87100642049 0.00158766160127012 0.000638553061192671 0.00326843667440656 0.99994055403638 0.999668833292177 0.99999849495964 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 7 6 1 6 1 3780 16045 0.00158478605388272 0.000581803608073282 0.0034461969631646 0.999937679172379 0.999652820032955 0.999998422174497 0.857142857142857 0.421276802956804 0.996389703138099 0.857142857142857 0.421276802956804 0.996389703138099 0.857142857142857 0.421276802956804 0.996389703138099 25.4682539682539 3.08757049174508 1164.0629045087 0.000282550572425536 135.5 1762 True False 0 0 0 0 0 0 0 25.4682539682539 3.08757049174508 1164.0629045087 0.00158478605388272 0.000581803608073282 0.0034461969631646 0.999937679172379 0.999652820032955 0.999998422174497 14 Assoc w RI 1) Assoc w R UP from AwRI to AwR yes 4 +Pyrazinamide pncA c.132C>T pncA_c.132C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide pncA c.138A>G pncA_c.138A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Consider that this variant might indicate that the isolate is M. canettii, which is intrinsically PZA resistant Now listed Silent mutation yes Q 0 +Pyrazinamide pncA c.-15A>C pncA_c.-15A>C 1 upstream_gene_variant 2289256 0 0 0 0 3 1 4406 16821 0.000680426400544341 0.000140342268876931 0.00198719451371054 0.99994055403638 0.999668833292177 0.99999849495964 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 1329 1830 False False 11.4532455742169 0.919224933680734 599.12689591493 0 0 0.000836889615584862 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 1 3783 16045 0.000792393026941363 0.000163440311798119 0.00231394549068866 0.999937679172379 0.999652820032955 0.999998422174497 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 1277 1762 False False 0 0 0 0 0 0 0 12.7240285487708 1.02115021686679 665.307410149575 0 0 0.000974644855475749 0.999937679172379 0.999652820032955 0.999998422174497 22 3) Uncertain significance No change no 1 +Pyrazinamide pncA c.-16_-11delAACGTAinsGGCAGTT pncA_c.-16_-11delAACGTAinsGGCAGTT 1 upstream_gene_variant 2289252 1 2 1 1 1 1 4408 16821 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 3.81601633393829 0.0486026416232846 298.829108180248 0.372217803874758 506.5 1830 False False 3.81601633393829 0.0486026416232846 298.829108180248 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA c.180C>T pncA_c.180C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0978301145652783 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide pncA c.195C>G pncA_c.195C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide pncA c.195C>T pncA_c.195C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 141 2332 4268 14490 0.031980040825584 0.026985157588128 0.0376067602563513 0.861372012840328 0.856057892899644 0.866560855415523 0.05701577031945 0.0482039912361942 0.0668938759046806 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.205274281782654 0.171349767427758 0.244309827742158 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 138 2320 3648 13726 0.0364500792393026 0.0307086873615531 0.0429204740176512 0.855415679920229 0.849878681893879 0.860823501490971 0.0561432058584214 0.047372850622176 0.0659888126623337 NA NA NA NA NA NA NA NA NA NA NA NA False True 1 1 1 0 0 0 1 0.223810401542649 0.186401863642136 0.266976360681126 NA NA NA NA NA NA 2683 5) Not assoc w R Now listed Silent mutation no 0 +Pyrazinamide pncA c.-19C>T pncA_c.-19C>T 1 upstream_gene_variant 2289260 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide pncA c.1A>C pncA_c.1A>C 1 initiator_codon_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide pncA c.201G>A pncA_c.201G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide pncA c.210G>A pncA_c.210G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide pncA c.-21G>A pncA_c.-21G>A 1 upstream_gene_variant 2289262 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 1 3) Uncertain significance No change no 1 +Pyrazinamide pncA c.222C>T pncA_c.222C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide pncA c.225T>C pncA_c.225T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 14 4409 16808 0 0 0.000836320411980403 0.999167756509333 0.998604030697473 0.99954493241661 0 0 0.231635761650116 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.14979365621044 NA NA NA NA NA NA 3) Uncertain significance 4) Not assoc w R - Interim WHO 4) Not assoc w R - interim 1 NA NA NA 0 13 3786 16033 0 0 0.000973872929872615 0.999189829240932 0.998614981804171 0.999568549911067 0 0 0.24705263800047 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.39026349064957 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide pncA c.246T>C pncA_c.246T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide pncA c.27G>C pncA_c.27G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 2 4407 16820 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.999881108072762 0.999570588169705 0.999985601311719 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.8166553210801 0.276553001924986 52.6392074577436 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 2 2 3784 16044 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999875358344758 0.999549824781286 0.999984904960856 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.2399577167019 0.307210542317908 58.5302826936734 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide pncA c.291T>G pncA_c.291T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide pncA c.-3_-2insC pncA_c.-3_-2insC 1 upstream_gene_variant 2289243 1 10 0 10 1 10 4408 16812 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999405540363809 0.998907040193061 0.999714897863756 0.0909090909090909 0.00229897221381426 0.412779916988382 0 0 0.30849710781876 0 0 0.30849710781876 0 0 1.70227199814187 0.23215423576241 475 1830 False False 0.381397459165154 0.00878994715518856 2.68235121662762 0 0 0.000836510060464794 0.999405540363809 0.998907040193061 0.999714897863756 3) Uncertain significance 4) Not assoc w R - Interim WHO 4) Not assoc w R - interim 1 10 0 10 1 10 3785 16036 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999376791723794 0.998854197426924 0.999701108243012 0.0909090909090909 0.00229897221381426 0.412779916988382 0 0 0.30849710781876 0 0 0.30849710781876 0 0 1.89108815161776 0.225505588118201 451 1762 False False 0 0 0 0 0 0 0 0.423672391017173 0.00976342393362646 2.97980157498564 0 0 0.000974130102511011 0.999376791723794 0.998854197426924 0.999701108243012 8 Not assoc w RI 4) Not assoc w R - Interim No change yes 1 +Pyrazinamide pncA c.300C>G pncA_c.300C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide pncA c.306G>A pncA_c.306G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0978301145652783 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide pncA c.309C>T pncA_c.309C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide pncA c.-33_-32insG pncA_c.-33_-32insG 1 upstream_gene_variant 2289273 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 2 3) Uncertain significance No change no 1 +Pyrazinamide pncA c.-33G>A pncA_c.-33G>A 1 upstream_gene_variant 2289274 1 5 0 5 0 5 4409 16817 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.16390782018879 0.590722354627394 560.5 1830 False False 0 0 4.16390782018879 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 3) Uncertain significance 4) Not assoc w R - Interim WHO 4) Not assoc w R - interim 1 5 0 5 0 5 3786 16041 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.62556638995023 0.590888399193514 509 1762 False False 0 0 0 0 0 0 0 0 0 4.62556638995023 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 1 Not assoc w RI 4) Not assoc w R - Interim No change yes 1 +Pyrazinamide pncA c.349C>T pncA_c.349C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide pncA c.361C>A pncA_c.361C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 4408 16821 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.81601633393829 0.0486026416232846 298.829108180248 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 3785 16045 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.23910171730515 0.0539892730999128 331.863925136224 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide pncA c.378T>C pncA_c.378T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0978301145652783 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide pncA c.393C>T pncA_c.393C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0978301145652783 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide pncA c.-39C>T pncA_c.-39C>T 1 upstream_gene_variant 2289280 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA c.-3C>T pncA_c.-3C>T 1 upstream_gene_variant 2289244 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide pncA c.3G>A pncA_c.3G>A 1 initiator_codon_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 2 4407 16820 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.999881108072762 0.999570588169705 0.999985601311719 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.8166553210801 0.276553001924986 52.6392074577436 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 2 3785 16044 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999875358344758 0.999549824781286 0.999984904960856 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.11941875825627 0.0359146288488272 40.7195918479678 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide pncA c.408T>C pncA_c.408T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide pncA c.453G>A pncA_c.453G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide pncA c.459C>T pncA_c.459C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide pncA c.465G>T pncA_c.465G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0978301145652783 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide pncA c.501C>T pncA_c.501C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide pncA c.514C>T pncA_c.514C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide pncA c.51C>T pncA_c.51C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide pncA c.540C>T pncA_c.540C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide pncA c.560G>A pncA_c.560G>A 1 stop_retained_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide pncA c.57G>C pncA_c.57G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0978301145652783 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide pncA c.-5delG pncA_c.-5delG 1 upstream_gene_variant 2289245 1 13 10 3 10 3 4399 16819 0.00226808800181447 0.00108815543692413 0.00416712622349087 0.999821662109142 0.999478910338162 0.999963220929399 0.769230769230769 0.461868460765959 0.949618926508848 0.769230769230769 0.461868460765959 0.949618926508848 0.769230769230769 0.461868460765959 0.949618926508848 12.7445631582935 3.27895111857834 72.0818533745033 2.26502158165053e-05 119 1830 True False 12.7445631582935 3.27895111857834 72.0818533745033 0.00226808800181447 0.00108815543692413 0.00416712622349087 0.999821662109142 0.999478910338162 0.999963220929399 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 13 10 3 10 3 3776 16043 0.00264131008980454 0.00126731492930415 0.00485208155788738 0.999813037517138 0.999453714469566 0.999961442181588 0.769230769230769 0.461868460765959 0.949618926508848 0.769230769230769 0.461868460765959 0.949618926508848 0.769230769230769 0.461868460765959 0.949618926508848 14.1622528248587 3.643448388114 80.0870700601526 1.03046028316755e-05 106 1762 True False 0 0 0 0 0 0 0 14.1622528248587 3.643448388114 80.0870700601526 0.00264131008980454 0.00126731492930415 0.00485208155788738 0.999813037517138 0.999453714469566 0.999961442181588 4 1) Assoc w R New AwR yes 5 +Pyrazinamide pncA c.-6G>C pncA_c.-6G>C 1 upstream_gene_variant 2289247 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide pncA c.6G>T pncA_c.6G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0978301145652783 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide pncA c.72C>A pncA_c.72C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide pncA c.72C>T pncA_c.72C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide pncA c.75C>G pncA_c.75C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide pncA c.-7T>C pncA_c.-7T>C 1 upstream_gene_variant 2289248 1 3 3 0 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 1.57702975056642 Inf 0.00895106588186537 214 1830 False False Inf 1.57702975056642 Inf 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 2 2 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.796077158748321 Inf 0.0364363919492442 248 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 8 Assoc w RI 2) Assoc w R - Interim No change yes 1 +Pyrazinamide pncA c.-7T>G pncA_c.-7T>G 1 upstream_gene_variant 2289248 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 14 3) Uncertain significance No change no 1 +Pyrazinamide pncA c.93C>T pncA_c.93C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide pncA c.-9G>A pncA_c.-9G>A 1 upstream_gene_variant 2289250 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide pncA deletion pncA_deletion 1 feature_ablation (see "Genomic_coordinates" sheet) 1 2 2 0 53 4 4356 16818 0.0120208664096166 0.0090170642909872 0.0156944308686741 0.999762216145523 0.999391291831884 0.999935208223951 0.929824561403508 0.829960180041358 0.98054957930529 1 0.158113883008419 1 0.333333333333333 0.0432718682927417 0.777221904496487 Inf 0.724853311712504 Inf 0.0423455169002443 239 1830 False False 51.1566804407713 18.829751899976 195.060105717364 0.000458926112895823 5.55829142526717e-05 0.00165680546669414 0.999762216145523 0.999391291831884 0.999935208223951 2) Assoc w R - Interim 2) Assoc w R - Interim ALL 3) Uncertain significance 1 1 1 0 44 3 3742 16043 0.0116217643951399 0.00845674135380153 0.0155705842548649 0.999813037517138 0.999453714469566 0.999961442181588 0.936170212765957 0.824607569987079 0.986638230502745 1 0.025 1 0.25 0.00630946320970987 0.805879550316756 Inf 0.109900804394861 Inf 0.189174163549984 309 1762 False False 0 0 0 0 0 0 0 62.8800997683948 20.1279874621403 319.111760957043 0.000267165375367352 6.76401879752305e-06 0.00148764146979829 0.999813037517138 0.999453714469566 0.999961442181588 137 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA LoF pncA_LoF 1 LoF (see "Genomic_coordinates" sheet) 1 543 508 35 573 42 3836 16780 0.129961442503969 0.120170011933774 0.140245858350132 0.997503269527999 0.996626627935302 0.998200001900088 0.93170731707317 0.908806362899818 0.950340799360557 0.935543278084714 0.911493405355275 0.954696459878275 0.923636363636363 0.898178195298049 0.944412248810048 63.4905407418441 44.9522291878539 92.1879564764702 1.12581886200728e-292 1 1830 True False 59.6786086697452 43.4445453465716 83.9025947588772 0.116942909760589 0.107531523815963 0.126872672111013 0.997503269527999 0.996626627935302 0.998200001900088 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 452 427 25 478 31 3308 16015 0.126254622292657 0.115834340903498 0.137255521776599 0.998068054343761 0.997258868578429 0.998686970855222 0.939096267190569 0.914662978189843 0.95824744745255 0.944690265486725 0.919431972605908 0.96389034039713 0.932314410480349 0.905298857354474 0.953551020844622 82.6892986698911 55.207338078647 129.878679406165 6.27877630604858e-280 1 1762 True False 0 0 0 0 0 0 0 74.6496274915161 51.7830624462589 111.137057532271 0.114323962516733 0.104289911433481 0.12496584020674 0.998068054343761 0.997258868578429 0.998686970855222 NA 1) Assoc w R UP from AwRI to AwR yes 4 +Pyrazinamide pncA p.Ala102fs pncA_p.Ala102fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Ala102Leu pncA_p.Ala102Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA p.Ala102Pro pncA_p.Ala102Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 7 1 8 1 4401 16821 0.00181447040145157 0.000783674794110066 0.0035720830153558 0.99994055403638 0.999668833292177 0.99999849495964 0.888888888888888 0.517503485082663 0.9971908632534 0.875 0.473490329124793 0.996840276468748 0.875 0.473490329124793 0.996840276468748 26.7546012269938 3.43510271518573 1198.14122320903 0.000108526777739821 135 1830 True False 30.5766871165644 4.09674326327108 1347.13599331235 0.00158802177858439 0.000638697975897407 0.00326917752821328 0.99994055403638 0.999668833292177 0.99999849495964 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 7 6 1 7 1 3779 16045 0.00184891706286318 0.000743673531480306 0.00380574231364529 0.999937679172379 0.999652820032955 0.999998422174497 0.875 0.473490329124793 0.996840276468748 0.857142857142857 0.421276802956804 0.996389703138099 0.857142857142857 0.421276802956804 0.996389703138099 25.4749933844932 3.08839326067251 1164.36872983696 0.000282199967119411 134 1762 True False 0 0 0 0 0 0 0 29.7208256152421 3.81564410496199 1329.90635130009 0.00158520475561426 0.00058195737791826 0.00344710660170385 0.999937679172379 0.999652820032955 0.999998422174497 12 Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Ala102Thr pncA_p.Ala102Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 2 2 2 2 4407 16820 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.999881108072762 0.999570588169705 0.999985601311719 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 3.8166553210801 0.276553001924986 52.6392074577436 0.192674584671704 327.5 1830 False False 3.8166553210801 0.276553001924986 52.6392074577436 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.999881108072762 0.999570588169705 0.999985601311719 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 4 2 2 2 2 3784 16044 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999875358344758 0.999549824781286 0.999984904960856 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 4.2399577167019 0.307210542317908 58.5302826936734 0.166974861221294 305 1762 False False 0 0 0 0 0 0 0 4.2399577167019 0.307210542317908 58.5302826936734 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999875358344758 0.999549824781286 0.999984904960856 2 2) Assoc w R - Interim UP from Uncertain to AwRI yes 4 +Pyrazinamide pncA p.Ala102Val pncA_p.Ala102Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 20 6 14 6 14 4403 16808 0.00136085280108868 0.000499567554195151 0.00295963286153356 0.999167756509333 0.998604030697473 0.99954493241661 0.3 0.118931590405727 0.542789182276289 0.3 0.118931590405727 0.542789182276289 0.3 0.118931590405727 0.542789182276289 1.63602738392654 0.51497703339314 4.53501121395123 0.280775383815328 483 1830 False False 1.63602738392654 0.51497703339314 4.53501121395123 0.00136085280108868 0.000499567554195151 0.00295963286153356 0.999167756509333 0.998604030697473 0.99954493241661 3) Uncertain significance 4) Not assoc w R - Interim WHO 4) Not assoc w R - interim 1 16 5 11 5 11 3781 16035 0.00132065504490227 0.000428947757354115 0.0030792549559865 0.999314470896173 0.998773730902855 0.999657738248111 0.3125 0.110169954717117 0.586620636451358 0.3125 0.110169954717117 0.586620636451358 0.3125 0.110169954717117 0.586620636451358 1.92770070447933 0.52473242700481 6.02242245403502 0.208854885803511 442 1762 False False 0 0 0 0 0 0 0 1.92770070447933 0.52473242700481 6.02242245403502 0.00132065504490227 0.000428947757354115 0.0030792549559865 0.999314470896173 0.998773730902855 0.999657738248111 49 4) Not assoc w R - Interim UP from Uncertain to NotAwRI yes 4 +Pyrazinamide pncA p.Ala134Gly pncA_p.Ala134Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 4408 16821 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 3.81601633393829 0.0486026416232846 298.829108180248 0.372217803874758 506.5 1830 False False 3.81601633393829 0.0486026416232846 298.829108180248 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 5 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Ala134Pro pncA_p.Ala134Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 4 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA p.Ala134Val pncA_p.Ala134Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 14 13 1 13 1 4396 16821 0.00294851440235881 0.00157086488136083 0.0050367716434693 0.99994055403638 0.999668833292177 0.99999849495964 0.928571428571428 0.661315510068178 0.998193219340874 0.928571428571428 0.661315510068178 0.998193219340874 0.928571428571428 0.661315510068178 0.998193219340874 49.7436305732484 7.46696225360555 2090.58078435287 1.48951169789342e-08 63 1830 True False 49.7436305732484 7.46696225360555 2090.58078435287 0.00294851440235881 0.00157086488136083 0.0050367716434693 0.99994055403638 0.999668833292177 0.99999849495964 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 13 12 1 12 1 3774 16045 0.00316957210776545 0.00163880353722015 0.00553005230777549 0.999937679172379 0.999652820032955 0.999998422174497 0.923076923076923 0.639702564732122 0.998054371502653 0.923076923076923 0.639702564732122 0.998054371502653 0.923076923076923 0.639702564732122 0.998054371502653 51.0174880763116 7.542725603712 2155.62757690633 2.47531098817422e-08 64.5 1762 True False 0 0 0 0 0 0 0 51.0174880763116 7.542725603712 2155.62757690633 0.00316957210776545 0.00163880353722015 0.00553005230777549 0.999937679172379 0.999652820032955 0.999998422174497 24 Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Ala143fs pncA_p.Ala143fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Ala143Gly pncA_p.Ala143Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 3 0 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 1.57702975056642 Inf 0.00895106588186537 214 1830 False False Inf 1.57702975056642 Inf 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 3 3 0 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 1.75196919627044 Inf 0.00695286470680484 189.5 1762 False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 3 Assoc w R 2) Assoc w R - Interim DOWN from AwR to AwRI yes 3 +Pyrazinamide pncA p.Ala143Thr pncA_p.Ala143Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA p.Ala143Val pncA_p.Ala143Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 6 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Ala146Glu pncA_p.Ala146Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 8 0 8 0 4401 16822 0.00181447040145157 0.000783674794110066 0.0035720830153558 1 0.999780735048249 1 1 0.63058335244718 1 1 0.63058335244718 1 1 0.63058335244718 1 Inf 6.5206569685433 Inf 3.44167929021015e-06 103.5 1830 True False Inf 6.5206569685433 Inf 0.00181447040145157 0.000783674794110066 0.0035720830153558 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 8 Evidence from ALL dataset only 2) Assoc w R - Interim UP from Uncertain to AwRI yes ALL only 4 +Pyrazinamide pncA p.Ala146Thr pncA_p.Ala146Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 19 15 4 15 4 4394 16818 0.0034021320027217 0.00190535929953375 0.005605100858211 0.999762216145523 0.999391291831884 0.999935208223951 0.789473684210526 0.544346918108494 0.93947546229071 0.789473684210526 0.544346918108494 0.93947546229071 0.789473684210526 0.544346918108494 0.93947546229071 14.3530951297223 4.56931651266777 59.4402166839907 9.25307078868706e-08 73 1830 True False 14.3530951297223 4.56931651266777 59.4402166839907 0.0034021320027217 0.00190535929953375 0.005605100858211 0.999762216145523 0.999391291831884 0.999935208223951 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 19 15 4 15 4 3771 16042 0.00396196513470681 0.002219125650155 0.0065262525797864 0.999750716689517 0.999361859844744 0.999932074644789 0.789473684210526 0.544346918108494 0.93947546229071 0.789473684210526 0.544346918108494 0.93947546229071 0.789473684210526 0.544346918108494 0.93947546229071 15.9526650755767 5.07716011426082 66.0928018355374 2.81801687928813e-08 66 1762 True False 0 0 0 0 0 0 0 15.9526650755767 5.07716011426082 66.0928018355374 0.00396196513470681 0.002219125650155 0.0065262525797864 0.999750716689517 0.999361859844744 0.999932074644789 31 Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Ala146Val pncA_p.Ala146Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 21 21 0 21 0 4388 16822 0.00476298480381038 0.00295070754491831 0.00727156014129481 1 0.999780735048249 1 1 0.83890238478092 1 1 0.83890238478092 1 1 0.83890238478092 1 Inf 19.9474932535322 Inf 4.44981729525412e-15 37 1830 True False Inf 19.9474932535322 Inf 0.00476298480381038 0.00295070754491831 0.00727156014129481 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 18 18 0 18 0 3768 16046 0.00475435816164817 0.00282009453029678 0.0075035659656758 1 0.999770132403032 1 1 0.814698031862147 1 1 0.814698031862147 1 1 0.814698031862147 1 Inf 18.7071703819603 Inf 1.09755773935772e-13 38 1762 True False 0 0 0 0 0 0 0 Inf 18.7071703819603 Inf 0.00475435816164817 0.00282009453029678 0.0075035659656758 1 0.999770132403032 1 126 Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Ala152fs pncA_p.Ala152fs 1 frameshift (see "Genomic_coordinates" sheet) 1 11 11 0 11 0 4398 16822 0.00249489680199591 0.00124608094986302 0.0044596646631454 1 0.999780735048249 1 1 0.715085847081845 1 1 0.715085847081845 1 1 0.715085847081845 1 Inf 9.59317044611859 Inf 3.06739337985067e-08 67 1830 True False Inf 9.59317044611859 Inf 0.00249489680199591 0.00124608094986302 0.0044596646631454 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 11 11 0 11 0 3775 16046 0.00290544109878499 0.00145125037710396 0.0051926765025673 1 0.999770132403032 1 1 0.715085847081845 1 1 0.715085847081845 1 1 0.715085847081845 1 Inf 10.6608738336509 Inf 1.21295522163799e-08 61 1762 True False 0 0 0 0 0 0 0 Inf 10.6608738336509 Inf 0.00290544109878499 0.00145125037710396 0.0051926765025673 1 0.999770132403032 1 16 1) Assoc w R UP from AwRI to AwR yes 4 +Pyrazinamide pncA p.Ala161fs pncA_p.Ala161fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.716637886286628 Inf 0.0431182613129385 265.5 1830 False False Inf 0.716637886286628 Inf 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 2 2 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.796077158748321 Inf 0.0364363919492442 248 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 3 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Ala161Gly pncA_p.Ala161Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1331 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1279 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA p.Ala161Pro pncA_p.Ala161Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA p.Ala165del pncA_p.Ala165del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Pyrazinamide pncA p.Ala165fs pncA_p.Ala165fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Ala171Asp pncA_p.Ala171Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA p.Ala171Glu pncA_p.Ala171Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 4 0 4 0 4405 16822 0.000907235200725788 0.000247244623732042 0.00232123869101376 1 0.999780735048249 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 2.51959224712996 Inf 0.00185784794966548 174 1830 True False Inf 2.51959224712996 Inf 0.000907235200725788 0.000247244623732042 0.00232123869101376 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 3 3 0 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 1.75196919627044 Inf 0.00695286470680484 189.5 1762 False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 21 Assoc w RI 2) Assoc w R - Interim No change yes 1 +Pyrazinamide pncA p.Ala171Gly pncA_p.Ala171Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA p.Ala171Pro pncA_p.Ala171Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.716637886286628 Inf 0.0431182613129385 265.5 1830 False False Inf 0.716637886286628 Inf 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 2 2 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.796077158748321 Inf 0.0364363919492442 248 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 4 2) Assoc w R - Interim New AwRI yes 5 +Pyrazinamide pncA p.Ala171Thr pncA_p.Ala171Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 4408 16821 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 3.81601633393829 0.0486026416232846 298.829108180248 0.372217803874758 506.5 1830 False False 3.81601633393829 0.0486026416232846 298.829108180248 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 3785 16045 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 4.23910171730515 0.0539892730999128 331.863925136224 0.345370788365398 466.5 1762 False False 0 0 0 0 0 0 0 4.23910171730515 0.0539892730999128 331.863925136224 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 12 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Ala171Val pncA_p.Ala171Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 3 6 3 6 4406 16816 0.000680426400544341 0.000140342268876931 0.00198719451371054 0.999643324218285 0.999223829869625 0.999869095386533 0.333333333333333 0.0748546314196918 0.700704943791459 0.333333333333333 0.0748546314196918 0.700704943791459 0.333333333333333 0.0748546314196918 0.700704943791459 1.9083068542896 0.308688624850231 8.94002964640908 0.405245638447081 514 1830 False False 1.9083068542896 0.308688624850231 8.94002964640908 0.000680426400544341 0.000140342268876931 0.00198719451371054 0.999643324218285 0.999223829869625 0.999869095386533 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 3 5 3 5 3783 16041 0.000792393026941363 0.000163440311798119 0.00231394549068866 0.999688395861897 0.99927297097682 0.999898815491092 0.375 0.0852334141372535 0.755136783633448 0.375 0.0852334141372535 0.755136783633448 0.375 0.0852334141372535 0.755136783633448 2.5441712926249 0.394894449816007 13.0803425612061 0.183369963500487 307 1762 False False 0 0 0 0 0 0 0 2.5441712926249 0.394894449816007 13.0803425612061 0.000792393026941363 0.000163440311798119 0.00231394549068866 0.999688395861897 0.99927297097682 0.999898815491092 19 Not assoc w RI 3) Uncertain significance DOWN from NotAwRI to Uncertain yes 2 +Pyrazinamide pncA p.Ala178_Ser179del pncA_p.Ala178_Ser179del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.716637886286628 Inf 0.0431182613129385 265.5 1830 False False Inf 0.716637886286628 Inf 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 2 2 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.796077158748321 Inf 0.0364363919492442 248 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 NA 2) Assoc w R - Interim No change yes 1 +Pyrazinamide pncA p.Ala178fs pncA_p.Ala178fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Ala20fs pncA_p.Ala20fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Ala26fs pncA_p.Ala26fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 4408 16821 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 3.81601633393829 0.0486026416232846 298.829108180248 0.372217803874758 506.5 1830 False False 3.81601633393829 0.0486026416232846 298.829108180248 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 3785 16045 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 4.23910171730515 0.0539892730999128 331.863925136224 0.345370788365398 466.5 1762 False False 0 0 0 0 0 0 0 4.23910171730515 0.0539892730999128 331.863925136224 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 3 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Ala26Val pncA_p.Ala26Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA p.Ala28_Leu172del pncA_p.Ala28_Leu172del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Pyrazinamide pncA p.Ala28Asp pncA_p.Ala28Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 4 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Ala28fs pncA_p.Ala28fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Ala3_Ile5del pncA_p.Ala3_Ile5del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Pyrazinamide pncA p.Ala30Val pncA_p.Ala30Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Ala36fs pncA_p.Ala36fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 7 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Ala36Pro pncA_p.Ala36Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA p.Ala39fs pncA_p.Ala39fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.716637886286628 Inf 0.0431182613129385 265.5 1830 False False Inf 0.716637886286628 Inf 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 2 2 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.796077158748321 Inf 0.0364363919492442 248 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 11 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Ala3fs pncA_p.Ala3fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.716637886286628 Inf 0.0431182613129385 265.5 1830 False False Inf 0.716637886286628 Inf 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 2 2 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.796077158748321 Inf 0.0364363919492442 248 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 5 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Ala3Glu pncA_p.Ala3Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 3 0 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 1.57702975056642 Inf 0.00895106588186537 214 1830 False False Inf 1.57702975056642 Inf 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 3 3 0 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 1.75196919627044 Inf 0.00695286470680484 189.5 1762 False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 4 Assoc w R Assoc w RI 2) Assoc w R - Interim No change yes 1 +Pyrazinamide pncA p.Ala3Pro pncA_p.Ala3Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA p.Ala46Glu pncA_p.Ala46Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 4 1 4 1 4405 16821 0.000907235200725788 0.000247244623732042 0.00232123869101376 0.99994055403638 0.999668833292177 0.99999849495964 0.8 0.28358206388191 0.994949236620532 0.8 0.28358206388191 0.994949236620532 0.8 0.28358206388191 0.994949236620532 15.2744608399545 1.5107888308703 749.051486258063 0.00774708678874264 197 1830 False False 15.2744608399545 1.5107888308703 749.051486258063 0.000907235200725788 0.000247244623732042 0.00232123869101376 0.99994055403638 0.999668833292177 0.99999849495964 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 3 3 0 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 1.75196919627044 Inf 0.00695286470680484 189.5 1762 False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 11 Assoc w RI 2) Assoc w R - Interim No change yes 1 +Pyrazinamide pncA p.Ala46Thr pncA_p.Ala46Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 2 2 4407 16820 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.999881108072762 0.999570588169705 0.999985601311719 0.5 0.067585986488543 0.932414013511457 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 1.90832766054005 0.0323387668486046 36.671823741687 0.502530085826874 520.5 1830 False False 3.8166553210801 0.276553001924986 52.6392074577436 0.000226860254083484 5.74358785768897e-06 0.0012633291757201 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 2 2 3784 16044 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999875358344758 0.999549824781286 0.999984904960856 0.5 0.067585986488543 0.932414013511457 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 2.11997885835095 0.0359241175697613 40.7303511527588 0.470274327371684 487.5 1762 False False 0 0 0 0 0 0 0 4.2399577167019 0.307210542317908 58.5302826936734 0.000264200792602377 6.68896256519433e-06 0.00147114392376758 0.999875358344758 0.999549824781286 0.999984904960856 4 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Ala46Val pncA_p.Ala46Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 4 1 4 1 4405 16821 0.000907235200725788 0.000247244623732042 0.00232123869101376 0.99994055403638 0.999668833292177 0.99999849495964 0.8 0.28358206388191 0.994949236620532 0.8 0.28358206388191 0.994949236620532 0.8 0.28358206388191 0.994949236620532 15.2744608399545 1.5107888308703 749.051486258063 0.00774708678874264 197 1830 False False 15.2744608399545 1.5107888308703 749.051486258063 0.000907235200725788 0.000247244623732042 0.00232123869101376 0.99994055403638 0.999668833292177 0.99999849495964 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 4 3 1 3 1 3783 16045 0.000792393026941363 0.000163440311798119 0.00231394549068866 0.999937679172379 0.999652820032955 0.999998422174497 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 12.7240285487708 1.02115021686679 665.307410149575 0.0238320316469516 213.5 1762 False False 0 0 0 0 0 0 0 12.7240285487708 1.02115021686679 665.307410149575 0.000792393026941363 0.000163440311798119 0.00231394549068866 0.999937679172379 0.999652820032955 0.999998422174497 18 Assoc w R Assoc w RI 2) Assoc w R - Interim No change yes 1 +Pyrazinamide pncA p.Ala79fs pncA_p.Ala79fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Ala79Thr pncA_p.Ala79Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.23555131695149 1 1273 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 4) Not assoc w R - Interim WHO 4) Not assoc w R - interim 1 3 0 3 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 10.2590571436125 1 554.5 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 NA Not assoc w RI 4) Not assoc w R - Interim No change yes 1 +Pyrazinamide pncA p.Ala79Val pncA_p.Ala79Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 8 Not assoc w RI 3) Uncertain significance DOWN from NotAwRI to Uncertain yes 2 +Pyrazinamide pncA p.Ala98fs pncA_p.Ala98fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 9 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Arg121Pro pncA_p.Arg121Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.716637886286628 Inf 0.0431182613129385 265.5 1830 False False Inf 0.716637886286628 Inf 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 2 2 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.796077158748321 Inf 0.0364363919492442 248 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 6 2) Assoc w R - Interim New AwRI yes 5 +Pyrazinamide pncA p.Arg123Pro pncA_p.Arg123Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 2 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Arg140fs pncA_p.Arg140fs 1 frameshift (see "Genomic_coordinates" sheet) 1 6 6 0 7 0 4402 16822 0.00158766160127012 0.000638553061192671 0.00326843667440656 1 0.999780735048249 1 1 0.590383602774996 1 1 0.540741873560099 1 1 0.540741873560099 1 Inf 4.49729646062438 Inf 7.99057346587355e-05 123.5 1830 True False Inf 5.50478416804174 Inf 0.0013611615245009 0.000499680922216912 0.00296030374676177 1 0.999780735048249 1 1) Assoc w R 2) Assoc w R - Interim WHO 2) Assoc w R - Interim 1 4 4 0 4 0 3782 16046 0.00105652403592181 0.000287939890647285 0.00270289202199999 1 0.999770132403032 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 2.79918348098377 Inf 0.0013264757267559 157.5 1762 True False 0 0 0 0 0 0 0 Inf 2.79918348098377 Inf 0.00105652403592181 0.000287939890647285 0.00270289202199999 1 0.999770132403032 1 25 Interim based on WHO dataset 2) Assoc w R - Interim No change no Interim on WHO 1 +Pyrazinamide pncA p.Arg140Gly pncA_p.Arg140Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA p.Arg140Pro pncA_p.Arg140Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 5 0 5 0 4404 16822 0.00113404400090723 0.000368320285107068 0.00264447958048867 1 0.999780735048249 1 1 0.478176249895018 1 1 0.478176249895018 1 1 0.478176249895018 1 Inf 3.49836879238979 Inf 0.000385538239896191 148 1830 True False Inf 3.49836879238979 Inf 0.00113404400090723 0.000368320285107068 0.00264447958048867 1 0.999780735048249 1 1) Assoc w R 2) Assoc w R - Interim WHO 2) Assoc w R - Interim 1 2 2 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.796077158748321 Inf 0.0364363919492442 248 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 Interim based on WHO dataset 2) Assoc w R - Interim UP from Uncertain to AwRI yes Interim on WHO 4 +Pyrazinamide pncA p.Arg140Ser pncA_p.Arg140Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 4408 16821 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 148.49048666616 1 897.5 1830 False False 3.81601633393829 0.0486026416232846 298.829108180248 0 0 0.000836510060464794 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 3785 16045 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 164.911820358037 1 927 1762 False False 0 0 0 0 0 0 0 4.23910171730515 0.0539892730999128 331.863925136224 0 0 0.000974130102511011 0.999937679172379 0.999652820032955 0.999998422174497 7 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Arg148Ser pncA_p.Arg148Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Arg154fs pncA_p.Arg154fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.716637886286628 Inf 0.0431182613129385 265.5 1830 False False Inf 0.716637886286628 Inf 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 22 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Arg154Gly pncA_p.Arg154Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 24 17 7 17 7 4392 16815 0.00385574960308459 0.00224767150840848 0.00616627368860949 0.999583878254666 0.99914281931165 0.999832681632407 0.708333333333333 0.489052186142167 0.873847911476308 0.708333333333333 0.489052186142167 0.873847911476308 0.708333333333333 0.489052186142167 0.873847911476308 9.29791178766588 3.66113876864789 26.5395297524151 1.83679083631497e-07 80 1830 True False 9.29791178766588 3.66113876864789 26.5395297524151 0.00385574960308459 0.00224767150840848 0.00616627368860949 0.999583878254666 0.99914281931165 0.999832681632407 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 23 16 7 16 7 3770 16039 0.00422609614368726 0.00241744983392875 0.00685386626076289 0.999563754206656 0.999101374817905 0.99982458915172 0.695652173913043 0.470808333991493 0.8678971203019 0.695652173913043 0.470808333991493 0.8678971203019 0.695652173913043 0.470808333991493 0.8678971203019 9.72428950359984 3.78103069384153 27.9787200475829 1.87484537179441e-07 71 1762 True False 0 0 0 0 0 0 0 9.72428950359984 3.78103069384153 27.9787200475829 0.00422609614368726 0.00241744983392875 0.00685386626076289 0.999563754206656 0.999101374817905 0.99982458915172 61 Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Arg154Met pncA_p.Arg154Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 5 0 5 0 4404 16822 0.00113404400090723 0.000368320285107068 0.00264447958048867 1 0.999780735048249 1 1 0.478176249895018 1 1 0.478176249895018 1 1 0.478176249895018 1 Inf 3.49836879238979 Inf 0.000385538239896191 148 1830 True False Inf 3.49836879238979 Inf 0.00113404400090723 0.000368320285107068 0.00264447958048867 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 5 5 0 5 0 3781 16046 0.00132065504490227 0.000428947757354115 0.0030792549559865 1 0.999770132403032 1 1 0.478176249895018 1 1 0.478176249895018 1 1 0.478176249895018 1 Inf 3.88652681138742 Inf 0.000253012467147004 128 1762 True False 0 0 0 0 0 0 0 Inf 3.88652681138742 Inf 0.00132065504490227 0.000428947757354115 0.0030792549559865 1 0.999770132403032 1 4 1) Assoc w R New AwR yes 5 +Pyrazinamide pncA p.Arg29fs pncA_p.Arg29fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.097852308370781 Inf 0.207630711257654 334.5 1830 False False Inf 0.716637886286628 Inf 0.000226860254083484 5.74358785768897e-06 0.0012633291757201 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.108701618838585 Inf 0.190862790580404 314.5 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0.000264200792602377 6.68896256519433e-06 0.00147114392376758 1 0.999770132403032 1 14 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Arg29Ser pncA_p.Arg29Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA p.Arg2Gln pncA_p.Arg2Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Arg2Leu pncA_p.Arg2Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Arg2Pro pncA_p.Arg2Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA p.Arg2Trp pncA_p.Arg2Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 4408 16821 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 3.81601633393829 0.0486026416232846 298.829108180248 0.372217803874758 506.5 1830 False False 3.81601633393829 0.0486026416232846 298.829108180248 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA p.Asn112fs pncA_p.Asn112fs 1 frameshift (see "Genomic_coordinates" sheet) 1 5 5 0 5 0 4404 16822 0.00113404400090723 0.000368320285107068 0.00264447958048867 1 0.999780735048249 1 1 0.478176249895018 1 1 0.478176249895018 1 1 0.478176249895018 1 Inf 3.49836879238979 Inf 0.000385538239896191 148 1830 True False Inf 3.49836879238979 Inf 0.00113404400090723 0.000368320285107068 0.00264447958048867 1 0.999780735048249 1 1) Assoc w R 2) Assoc w R - Interim WHO 2) Assoc w R - Interim 1 4 4 0 4 0 3782 16046 0.00105652403592181 0.000287939890647285 0.00270289202199999 1 0.999770132403032 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 2.79918348098377 Inf 0.0013264757267559 157.5 1762 True False 0 0 0 0 0 0 0 Inf 2.79918348098377 Inf 0.00105652403592181 0.000287939890647285 0.00270289202199999 1 0.999770132403032 1 5 Interim based on WHO dataset 2) Assoc w R - Interim No change no Interim on WHO 1 +Pyrazinamide pncA p.Asn11His pncA_p.Asn11His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1332 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1280 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Asn11Ser pncA_p.Asn11Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 4408 16821 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 3.81601633393829 0.0486026416232846 298.829108180248 0.372217803874758 506.5 1830 False False 3.81601633393829 0.0486026416232846 298.829108180248 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 3785 16045 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 4.23910171730515 0.0539892730999128 331.863925136224 0.345370788365398 466.5 1762 False False 0 0 0 0 0 0 0 4.23910171730515 0.0539892730999128 331.863925136224 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Asn149Asp pncA_p.Asn149Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA p.Asn149fs pncA_p.Asn149fs 1 frameshift (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 3 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Asp110_Asn112del pncA_p.Asp110_Asn112del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Pyrazinamide pncA p.Asp110Gly pncA_p.Asp110Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 2 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Asp126_Val130del pncA_p.Asp126_Val130del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 3 2 1 12 1 4397 16821 0.00272170560217736 0.00140711126319081 0.00474944049676375 0.99994055403638 0.999668833292177 0.99999849495964 0.923076923076923 0.639702564732122 0.998054371502653 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 7.65112576756879 0.398185206666402 450.070216984226 0.111084279147516 303 1830 False False 45.9067546054127 6.78733808586374 1942.29819734014 0.000454648783814503 5.50648201816062e-05 0.00164137271279767 0.99994055403638 0.999668833292177 0.99999849495964 2) Assoc w R - Interim 2) Assoc w R - Interim ALL 3) Uncertain significance 1 1 1 0 10 0 3776 16046 0.00264131008980454 0.00126731492930415 0.00485208155788738 1 0.999770132403032 1 1 0.691502892181239 1 1 0.025 1 1 0.025 1 Inf 0.108931858242969 Inf 0.190536245775109 310 1762 False False 0 0 0 0 0 0 0 Inf 9.51788812022163 Inf 0.000264760391845379 6.70313029650839e-06 0.00147425804327866 1 0.999770132403032 1 16 2) Assoc w R - Interim No change yes 1 +Pyrazinamide pncA p.Asp126fs pncA_p.Asp126fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Asp129_Val131del pncA_p.Asp129_Val131del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 12 12 0 12 0 4397 16822 0.00272170560217736 0.00140711126319081 0.00474944049676375 1 0.999780735048249 1 1 0.735351530602948 1 1 0.735351530602948 1 1 0.735351530602948 1 Inf 10.6239097645824 Inf 6.35739683533611e-09 61 1830 True False Inf 10.6239097645824 Inf 0.00272170560217736 0.00140711126319081 0.00474944049676375 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 12 12 0 12 0 3774 16046 0.00316957210776545 0.00163880353722015 0.00553005230777549 1 0.999770132403032 1 1 0.735351530602948 1 1 0.735351530602948 1 1 0.735351530602948 1 Inf 11.8050954092125 Inf 2.31012863209904e-09 55.5 1762 True False 0 0 0 0 0 0 0 Inf 11.8050954092125 Inf 0.00316957210776545 0.00163880353722015 0.00553005230777549 1 0.999770132403032 1 19 1) Assoc w R UP from AwRI to AwR yes 4 +Pyrazinamide pncA p.Asp129Asn pncA_p.Asp129Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 3 1 3 1 4406 16821 0.000680426400544341 0.000140342268876931 0.00198719451371054 0.99994055403638 0.999668833292177 0.99999849495964 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 11.4532455742169 0.919224933680734 599.12689591493 0.030230719678465 231.5 1830 False False 11.4532455742169 0.919224933680734 599.12689591493 0.000680426400544341 0.000140342268876931 0.00198719451371054 0.99994055403638 0.999668833292177 0.99999849495964 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 4 3 1 3 1 3783 16045 0.000792393026941363 0.000163440311798119 0.00231394549068866 0.999937679172379 0.999652820032955 0.999998422174497 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 12.7240285487708 1.02115021686679 665.307410149575 0.0238320316469516 213.5 1762 False False 0 0 0 0 0 0 0 12.7240285487708 1.02115021686679 665.307410149575 0.000792393026941363 0.000163440311798119 0.00231394549068866 0.999937679172379 0.999652820032955 0.999998422174497 1 2) Assoc w R - Interim UP from Uncertain to AwRI yes 4 +Pyrazinamide pncA p.Asp129del pncA_p.Asp129del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 4 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Pyrazinamide pncA p.Asp129fs pncA_p.Asp129fs 1 frameshift (see "Genomic_coordinates" sheet) 1 9 9 0 9 0 4400 16822 0.00204127920163302 0.000933814369660709 0.00387143149170671 1 0.999780735048249 1 1 0.663732883120057 1 1 0.663732883120057 1 1 0.663732883120057 1 Inf 7.54177743415507 Inf 7.13698843528946e-07 90.5 1830 True False Inf 7.54177743415507 Inf 0.00204127920163302 0.000933814369660709 0.00387143149170671 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 9 9 0 9 0 3777 16046 0.00237717908082408 0.00108755584228183 0.00450780893694816 1 0.999770132403032 1 1 0.663732883120057 1 1 0.663732883120057 1 1 0.663732883120057 1 Inf 8.37964612204265 Inf 3.34181689819727e-07 76.5 1762 True False 0 0 0 0 0 0 0 Inf 8.37964612204265 Inf 0.00237717908082408 0.00108755584228183 0.00450780893694816 1 0.999770132403032 1 7 1) Assoc w R UP from AwRI to AwR yes 4 +Pyrazinamide pncA p.Asp129Gly pncA_p.Asp129Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA p.Asp12Ala pncA_p.Asp12Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 25 18 7 18 7 4391 16815 0.00408255840326604 0.00242132299966848 0.00644455638933336 0.999583878254666 0.99914281931165 0.999832681632407 0.72 0.506123178193744 0.879283311495933 0.72 0.506123178193744 0.879283311495933 0.72 0.506123178193744 0.879283311495933 9.84708982659335 3.9209063095379 27.9204835902404 5.25342576924679e-08 68 1830 True False 9.84708982659335 3.9209063095379 27.9204835902404 0.00408255840326604 0.00242132299966848 0.00644455638933336 0.999583878254666 0.99914281931165 0.999832681632407 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 19 14 5 14 5 3772 16041 0.00369783412572636 0.00202306972195899 0.00619656153938766 0.999688395861897 0.99927297097682 0.999898815491092 0.736842105263157 0.487970654654127 0.908534215092333 0.736842105263157 0.487970654654127 0.908534215092333 0.736842105263157 0.487970654654127 0.908534215092333 11.9074231177094 4.04871705317325 42.2815029097583 3.66967993953364e-07 82.5 1762 True False 0 0 0 0 0 0 0 11.9074231177094 4.04871705317325 42.2815029097583 0.00369783412572636 0.00202306972195899 0.00619656153938766 0.999688395861897 0.99927297097682 0.999898815491092 72 Assoc w R Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Asp12Asn pncA_p.Asp12Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 5 1 6 1 4403 16821 0.00136085280108868 0.000499567554195151 0.00295963286153356 0.99994055403638 0.999668833292177 0.99999849495964 0.857142857142857 0.421276802956804 0.996389703138099 0.833333333333333 0.358765421002325 0.99578925548551 0.833333333333333 0.358765421002325 0.99578925548551 19.1017488076311 2.13628958128708 899.024496670605 0.00191162174887075 186 1830 True False 22.9220985691573 2.7794245182276 1048.43039728317 0.00113430127041742 0.000368403864880028 0.00264507905390205 0.99994055403638 0.999668833292177 0.99999849495964 1) Assoc w R 2) Assoc w R - Interim WHO 2) Assoc w R - Interim 1 5 4 1 5 1 3781 16045 0.00132065504490227 0.000428947757354115 0.0030792549559865 0.999937679172379 0.999652820032955 0.999998422174497 0.833333333333333 0.358765421002325 0.99578925548551 0.8 0.28358206388191 0.994949236620532 0.8 0.28358206388191 0.994949236620532 16.9743454112668 1.67878435353491 831.972674111947 0.00561573975221539 173.5 1762 False False 0 0 0 0 0 0 0 21.2179317640835 2.3726027647035 998.008782436883 0.00105680317040951 0.000288015983802204 0.00270360553930617 0.999937679172379 0.999652820032955 0.999998422174497 21 Assoc w R Assoc w RI Interim based on WHO dataset 2) Assoc w R - Interim No change yes Interim on WHO 1 +Pyrazinamide pncA p.Asp12fs pncA_p.Asp12fs 1 frameshift (see "Genomic_coordinates" sheet) 1 4 4 0 4 0 4405 16822 0.000907235200725788 0.000247244623732042 0.00232123869101376 1 0.999780735048249 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 2.51959224712996 Inf 0.00185784794966548 174 1830 True False Inf 2.51959224712996 Inf 0.000907235200725788 0.000247244623732042 0.00232123869101376 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 4 4 0 4 0 3782 16046 0.00105652403592181 0.000287939890647285 0.00270289202199999 1 0.999770132403032 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 2.79918348098377 Inf 0.0013264757267559 157.5 1762 True False 0 0 0 0 0 0 0 Inf 2.79918348098377 Inf 0.00105652403592181 0.000287939890647285 0.00270289202199999 1 0.999770132403032 1 10 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Asp12Glu pncA_p.Asp12Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 6 0 6 0 4403 16822 0.00136085280108868 0.000499567554195151 0.00295963286153356 1 0.999780735048249 1 1 0.540741873560099 1 1 0.540741873560099 1 1 0.540741873560099 1 Inf 4.49627002862219 Inf 7.99920101998881e-05 128.5 1830 True False Inf 4.49627002862219 Inf 0.00136085280108868 0.000499567554195151 0.00295963286153356 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 5 5 0 5 0 3781 16046 0.00132065504490227 0.000428947757354115 0.0030792549559865 1 0.999770132403032 1 1 0.478176249895018 1 1 0.478176249895018 1 1 0.478176249895018 1 Inf 3.88652681138742 Inf 0.000253012467147004 128 1762 True False 0 0 0 0 0 0 0 Inf 3.88652681138742 Inf 0.00132065504490227 0.000428947757354115 0.0030792549559865 1 0.999770132403032 1 8 Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Asp12Gly pncA_p.Asp12Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 16 13 3 13 3 4396 16819 0.00294851440235881 0.00157086488136083 0.0050367716434693 0.999821662109142 0.999478910338162 0.999963220929399 0.8125 0.543543453768388 0.959526266094054 0.8125 0.543543453768388 0.959526266094054 0.8125 0.543543453768388 0.959526266094054 16.5792387018501 4.55280012590525 90.7489030220016 3.88940358051126e-07 83 1830 True False 16.5792387018501 4.55280012590525 90.7489030220016 0.00294851440235881 0.00157086488136083 0.0050367716434693 0.999821662109142 0.999478910338162 0.999963220929399 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 10 8 2 8 2 3778 16044 0.00211304807184363 0.00091269178353604 0.00415927925423806 0.999875358344758 0.999549824781286 0.999984904960856 0.8 0.443904537692358 0.974789273673166 0.8 0.443904537692358 0.974789273673166 0.8 0.443904537692358 0.974789273673166 16.9867654843832 3.3873087569822 164.067108627238 5.44663482945022e-05 117 1762 True False 0 0 0 0 0 0 0 16.9867654843832 3.3873087569822 164.067108627238 0.00211304807184363 0.00091269178353604 0.00415927925423806 0.999875358344758 0.999549824781286 0.999984904960856 19 Assoc w R Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Asp12His pncA_p.Asp12His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.097852308370781 Inf 0.207630711257654 334.5 1830 False False Inf 0.716637886286628 Inf 0.000226860254083484 5.74358785768897e-06 0.0012633291757201 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.108701618838585 Inf 0.190862790580404 314.5 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0.000264200792602377 6.68896256519433e-06 0.00147114392376758 1 0.999770132403032 1 NA 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Asp136_Leu156del pncA_p.Asp136_Leu156del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Pyrazinamide pncA p.Asp136Ala pncA_p.Asp136Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 4 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Asp136Asn pncA_p.Asp136Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 1 3 1 3 4408 16819 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999821662109142 0.999478910338162 0.999963220929399 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 1.2718542044767 0.0242215257537785 15.8425197757275 1 1273 1830 False False 1.2718542044767 0.0242215257537785 15.8425197757275 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 1 3 1 3 3785 16043 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999813037517138 0.999453714469566 0.999961442181588 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 1.41285777190664 0.0269058536042688 17.5998124179982 0.571480992034284 501.5 1762 False False 0 0 0 0 0 0 0 1.41285777190664 0.0269058536042688 17.5998124179982 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999813037517138 0.999453714469566 0.999961442181588 6 Not assoc w RI 3) Uncertain significance DOWN from NotAwRI to Uncertain yes 2 +Pyrazinamide pncA p.Asp136fs pncA_p.Asp136fs 1 frameshift (see "Genomic_coordinates" sheet) 1 10 9 1 9 1 4400 16821 0.00204127920163302 0.000933814369660709 0.00387143149170671 0.99994055403638 0.999668833292177 0.99999849495964 0.9 0.554983882971804 0.997471421455538 0.9 0.554983882971804 0.997471421455538 0.9 0.554983882971804 0.997471421455538 34.4065909090909 4.7638329340069 1496.2181371413 5.80523486805988e-06 108.5 1830 True False 34.4065909090909 4.7638329340069 1496.2181371413 0.00204127920163302 0.000933814369660709 0.00387143149170671 0.99994055403638 0.999668833292177 0.99999849495964 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 5 5 0 5 0 3781 16046 0.00132065504490227 0.000428947757354115 0.0030792549559865 1 0.999770132403032 1 1 0.478176249895018 1 1 0.478176249895018 1 1 0.478176249895018 1 Inf 3.88652681138742 Inf 0.000253012467147004 128 1762 True False 0 0 0 0 0 0 0 Inf 3.88652681138742 Inf 0.00132065504490227 0.000428947757354115 0.0030792549559865 1 0.999770132403032 1 39 1) Assoc w R UP from AwRI to AwR yes 4 +Pyrazinamide pncA p.Asp136Glu pncA_p.Asp136Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Asp136Gly pncA_p.Asp136Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 24 18 6 18 6 4391 16816 0.00408255840326604 0.00242132299966848 0.00644455638933336 0.999643324218285 0.999223829869625 0.999869095386533 0.75 0.53288719757733 0.902269590525467 0.75 0.53288719757733 0.902269590525467 0.75 0.53288719757733 0.902269590525467 11.4889546800273 4.36519113599742 35.3944058946572 1.82798375007211e-08 65 1830 True False 11.4889546800273 4.36519113599742 35.3944058946572 0.00408255840326604 0.00242132299966848 0.00644455638933336 0.999643324218285 0.999223829869625 0.999869095386533 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 20 16 4 16 4 3770 16042 0.00422609614368726 0.00241744983392875 0.00685386626076289 0.999750716689517 0.999361859844744 0.999932074644789 0.8 0.563385997003331 0.942666002949967 0.8 0.563385997003331 0.942666002949967 0.8 0.563385997003331 0.942666002949967 17.0206896551724 5.4856885738138 69.8854999851518 6.68068736645522e-09 58 1762 True False 0 0 0 0 0 0 0 17.0206896551724 5.4856885738138 69.8854999851518 0.00422609614368726 0.00241744983392875 0.00685386626076289 0.999750716689517 0.999361859844744 0.999932074644789 78 1) Assoc w R UP from Uncertain to AwR yes 4 +Pyrazinamide pncA p.Asp136His pncA_p.Asp136His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA p.Asp136Tyr pncA_p.Asp136Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 11 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA p.Asp136Val pncA_p.Asp136Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.716637886286628 Inf 0.0431182613129385 265.5 1830 False False Inf 0.716637886286628 Inf 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 2 2 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.796077158748321 Inf 0.0364363919492442 248 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 2) Assoc w R - Interim UP from Uncertain to AwRI yes 4 +Pyrazinamide pncA p.Asp145Glu pncA_p.Asp145Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1334 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1282 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 2 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Asp145Tyr pncA_p.Asp145Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1326 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1274 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Asp158Asn pncA_p.Asp158Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Asp158fs pncA_p.Asp158fs 1 frameshift (see "Genomic_coordinates" sheet) 1 3 3 0 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 1.57702975056642 Inf 0.00895106588186537 214 1830 False False Inf 1.57702975056642 Inf 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 3 3 0 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 1.75196919627044 Inf 0.00695286470680484 189.5 1762 False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 6 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Asp166fs pncA_p.Asp166fs 1 frameshift (see "Genomic_coordinates" sheet) 1 3 3 0 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 1.57702975056642 Inf 0.00895106588186537 214 1830 False False Inf 1.57702975056642 Inf 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 6 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Asp40fs pncA_p.Asp40fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.716637886286628 Inf 0.0431182613129385 265.5 1830 False False Inf 0.716637886286628 Inf 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 2 2 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.796077158748321 Inf 0.0364363919492442 248 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 5 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Asp49Ala pncA_p.Asp49Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 10 10 0 10 0 4399 16822 0.00226808800181447 0.00108815543692413 0.00416712622349087 1 0.999780735048249 1 1 0.691502892181239 1 1 0.691502892181239 1 1 0.691502892181239 1 Inf 8.56754994230848 Inf 1.47972618581065e-07 77 1830 True False Inf 8.56754994230848 Inf 0.00226808800181447 0.00108815543692413 0.00416712622349087 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 9 9 0 9 0 3777 16046 0.00237717908082408 0.00108755584228183 0.00450780893694816 1 0.999770132403032 1 1 0.663732883120057 1 1 0.663732883120057 1 1 0.663732883120057 1 Inf 8.37964612204265 Inf 3.34181689819727e-07 76.5 1762 True False 0 0 0 0 0 0 0 Inf 8.37964612204265 Inf 0.00237717908082408 0.00108755584228183 0.00450780893694816 1 0.999770132403032 1 27 Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Asp49Asn pncA_p.Asp49Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 5 1 5 1 4404 16821 0.00113404400090723 0.000368320285107068 0.00264447958048867 0.99994055403638 0.999668833292177 0.99999849495964 0.833333333333333 0.358765421002325 0.99578925548551 0.833333333333333 0.358765421002325 0.99578925548551 0.833333333333333 0.358765421002325 0.99578925548551 19.0974114441416 2.13580486483461 898.821488982459 0.0019132693883777 189.5 1830 True False 19.0974114441416 2.13580486483461 898.821488982459 0.00113404400090723 0.000368320285107068 0.00264447958048867 0.99994055403638 0.999668833292177 0.99999849495964 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 24 Assoc w RI Evidence from ALL dataset only 2) Assoc w R - Interim no change yes ALL only 1 +Pyrazinamide pncA p.Asp49fs pncA_p.Asp49fs 1 frameshift (see "Genomic_coordinates" sheet) 1 4 3 1 3 1 4406 16821 0.000680426400544341 0.000140342268876931 0.00198719451371054 0.99994055403638 0.999668833292177 0.99999849495964 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 11.4532455742169 0.919224933680734 599.12689591493 0.030230719678465 231.5 1830 False False 11.4532455742169 0.919224933680734 599.12689591493 0.000680426400544341 0.000140342268876931 0.00198719451371054 0.99994055403638 0.999668833292177 0.99999849495964 2) Assoc w R - Interim 2) Assoc w R - Interim ALL 3) Uncertain significance 1 2 1 1 1 1 3785 16045 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 4.23910171730515 0.0539892730999128 331.863925136224 0.345370788365398 466.5 1762 False False 0 0 0 0 0 0 0 4.23910171730515 0.0539892730999128 331.863925136224 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 NA 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Asp49Glu pncA_p.Asp49Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.716637886286628 Inf 0.0431182613129385 265.5 1830 False False Inf 0.716637886286628 Inf 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 2 2 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.796077158748321 Inf 0.0364363919492442 248 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 5 Assoc w RI 2) Assoc w R - Interim No change yes 1 +Pyrazinamide pncA p.Asp49Gly pncA_p.Asp49Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 45 43 2 43 2 4366 16820 0.00975277840780222 0.00706687257233482 0.0131146729814392 0.999881108072762 0.999570588169705 0.999985601311719 0.955555555555555 0.84850709975666 0.994571511299749 0.955555555555555 0.84850709975666 0.994571511299749 0.955555555555555 0.84850709975666 0.994571511299749 82.8286761337608 21.560814467741 704.63806494263 2.37942823589608e-27 18 1830 True False 82.8286761337608 21.560814467741 704.63806494263 0.00975277840780222 0.00706687257233482 0.0131146729814392 0.999881108072762 0.999570588169705 0.999985601311719 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 45 43 2 43 2 3743 16044 0.0113576333861595 0.00823143317696189 0.0152684689795526 0.999875358344758 0.999549824781286 0.999984904960856 0.955555555555555 0.84850709975666 0.994571511299749 0.955555555555555 0.84850709975666 0.994571511299749 0.955555555555555 0.84850709975666 0.994571511299749 92.1576275714667 23.9815025949623 777.832671651466 6.44082832590208e-29 14 1762 True False 0 0 0 0 0 0 0 92.1576275714667 23.9815025949623 777.832671651466 0.0113576333861595 0.00823143317696189 0.0152684689795526 0.999875358344758 0.999549824781286 0.999984904960856 197 Assoc w R Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Asp49Tyr pncA_p.Asp49Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Asp56fs pncA_p.Asp56fs 1 frameshift (see "Genomic_coordinates" sheet) 1 4 4 0 5 0 4404 16822 0.00113404400090723 0.000368320285107068 0.00264447958048867 1 0.999780735048249 1 1 0.478176249895018 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 2.52016409354347 Inf 0.00185651221847041 163.5 1830 True False Inf 3.49836879238979 Inf 0.000907441016333938 0.0002473007258695 0.00232176491492765 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 4 4 0 5 0 3781 16046 0.00132065504490227 0.000428947757354115 0.0030792549559865 1 0.999770132403032 1 1 0.478176249895018 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 2.7999233027091 Inf 0.00132534158702044 145.5 1762 True False 0 0 0 0 0 0 0 Inf 3.88652681138742 Inf 0.00105680317040951 0.000288015983802204 0.00270360553930617 1 0.999770132403032 1 6 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Asp56His pncA_p.Asp56His 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1327 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1275 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA p.Asp63_Ser67delinsGlu pncA_p.Asp63_Ser67delinsGlu 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 3 2 1 2 1 4407 16821 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.99994055403638 0.999668833292177 0.99999849495964 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 7.63376446562287 0.397281353658273 449.052313013199 0.111452652175084 308.5 1830 False False 7.63376446562287 0.397281353658273 449.052313013199 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.99994055403638 0.999668833292177 0.99999849495964 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 3 2 1 2 1 3784 16045 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999937679172379 0.999652820032955 0.999998422174497 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 8.48044397463002 0.441282441622781 498.676520130596 0.0954034464341229 286.5 1762 False False 0 0 0 0 0 0 0 8.48044397463002 0.441282441622781 498.676520130596 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999937679172379 0.999652820032955 0.999998422174497 13 2) Assoc w R - Interim No change yes 1 +Pyrazinamide pncA p.Asp63Ala pncA_p.Asp63Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 30 25 5 26 5 4383 16817 0.00589702880471762 0.00385564427656477 0.00862865525716627 0.999702770181904 0.999306502227134 0.999903483469113 0.838709677419354 0.66272841502682 0.945475673784916 0.833333333333333 0.652788301165856 0.943578303531928 0.833333333333333 0.652788301165856 0.943578303531928 19.1843486196668 7.20611644230286 64.2450841662649 3.81815553232928e-13 43 1830 True False 19.9517225644535 7.53167473743009 66.5651418756331 0.00567150635208711 0.00367356282188775 0.00836095148601356 0.999702770181904 0.999306502227134 0.999903483469113 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 26 23 3 24 3 3762 16043 0.0063391442155309 0.00406570767048984 0.00941755049868986 0.999813037517138 0.999453714469566 0.999961442181588 0.888888888888888 0.708413075726448 0.976472545619146 0.884615384615384 0.698459599892432 0.975541924682037 0.884615384615384 0.698459599892432 0.975541924682037 32.6944001417685 9.86865774678288 170.552704585315 3.85799198045887e-14 36 1762 True False 0 0 0 0 0 0 0 34.1158958001063 10.3473268083116 176.998754283259 0.00607661822985469 0.00385583888513256 0.00910403999899345 0.999813037517138 0.999453714469566 0.999961442181588 38 Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Asp63fs pncA_p.Asp63fs 1 frameshift (see "Genomic_coordinates" sheet) 1 7 6 1 6 1 4403 16821 0.00136085280108868 0.000499567554195151 0.00295963286153356 0.99994055403638 0.999668833292177 0.99999849495964 0.857142857142857 0.421276802956804 0.996389703138099 0.857142857142857 0.421276802956804 0.996389703138099 0.857142857142857 0.421276802956804 0.996389703138099 22.9220985691573 2.7794245182276 1048.43039728317 0.000460380871141943 155.5 1830 True False 22.9220985691573 2.7794245182276 1048.43039728317 0.00136085280108868 0.000499567554195151 0.00295963286153356 0.99994055403638 0.999668833292177 0.99999849495964 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 6 5 1 5 1 3781 16045 0.00132065504490227 0.000428947757354115 0.0030792549559865 0.999937679172379 0.999652820032955 0.999998422174497 0.833333333333333 0.358765421002325 0.99578925548551 0.833333333333333 0.358765421002325 0.99578925548551 0.833333333333333 0.358765421002325 0.99578925548551 21.2179317640835 2.3726027647035 998.008782436883 0.00127682798332212 142 1762 True False 0 0 0 0 0 0 0 21.2179317640835 2.3726027647035 998.008782436883 0.00132065504490227 0.000428947757354115 0.0030792549559865 0.999937679172379 0.999652820032955 0.999998422174497 NA 1) Assoc w R UP from AwRI to AwR yes 4 +Pyrazinamide pncA p.Asp63Glu pncA_p.Asp63Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 3 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA p.Asp63Gly pncA_p.Asp63Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 12 7 5 7 5 4402 16817 0.00158766160127012 0.000638553061192671 0.00326843667440656 0.999702770181904 0.999306502227134 0.999903483469113 0.583333333333333 0.276669685682105 0.848347770191569 0.583333333333333 0.276669685682105 0.848347770191569 0.583333333333333 0.276669685682105 0.848347770191569 5.34843253066787 1.46029651765581 21.3789378597995 0.00486730956794123 194 1830 True False 5.34843253066787 1.46029651765581 21.3789378597995 0.00158766160127012 0.000638553061192671 0.00326843667440656 0.999702770181904 0.999306502227134 0.999903483469113 1) Assoc w R 2) Assoc w R - Interim WHO 2) Assoc w R - Interim 1 11 6 5 6 5 3780 16041 0.00158478605388272 0.000581803608073282 0.0034461969631646 0.999688395861897 0.99927297097682 0.999898815491092 0.545454545454545 0.233793597659345 0.832511905936292 0.545454545454545 0.233793597659345 0.832511905936292 0.545454545454545 0.233793597659345 0.832511905936292 5.09238095238095 1.29396353081491 21.1023568979633 0.00920874438497631 206 1762 False False 0 0 0 0 0 0 0 5.09238095238095 1.29396353081491 21.1023568979633 0.00158478605388272 0.000581803608073282 0.0034461969631646 0.999688395861897 0.99927297097682 0.999898815491092 29 Assoc w R Assoc w RI Interim based on WHO dataset 2) Assoc w R - Interim No change yes Interim on WHO 1 +Pyrazinamide pncA p.Asp63Val pncA_p.Asp63Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA p.Asp80fs pncA_p.Asp80fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Asp80Val pncA_p.Asp80Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Asp86fs pncA_p.Asp86fs 1 frameshift (see "Genomic_coordinates" sheet) 1 7 7 0 7 0 4402 16822 0.00158766160127012 0.000638553061192671 0.00326843667440656 1 0.999780735048249 1 1 0.590383602774996 1 1 0.590383602774996 1 1 0.590383602774996 1 Inf 5.50478416804174 Inf 1.65938667095456e-05 115.5 1830 True False Inf 5.50478416804174 Inf 0.00158766160127012 0.000638553061192671 0.00326843667440656 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 6 6 0 6 0 3780 16046 0.00158478605388272 0.000581803608073282 0.0034461969631646 1 0.999770132403032 1 1 0.540741873560099 1 1 0.540741873560099 1 1 0.540741873560099 1 Inf 4.99466385094306 Inf 4.82493639119799e-05 113.5 1762 True False 0 0 0 0 0 0 0 Inf 4.99466385094306 Inf 0.00158478605388272 0.000581803608073282 0.0034461969631646 1 0.999770132403032 1 14 1) Assoc w R UP from AwRI to AwR yes 4 +Pyrazinamide pncA p.Asp86Gly pncA_p.Asp86Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Asp8Ala pncA_p.Asp8Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 3 0 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 1.57702975056642 Inf 0.00895106588186537 214 1830 False False Inf 1.57702975056642 Inf 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 2 2 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.796077158748321 Inf 0.0364363919492442 248 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 7 Assoc w RI 2) Assoc w R - Interim No change yes 1 +Pyrazinamide pncA p.Asp8Asn pncA_p.Asp8Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 14 14 0 14 0 4395 16822 0.00317532320254025 0.00173703251080297 0.00532191922970533 1 0.999780735048249 1 1 0.768364238349883 1 1 0.768364238349883 1 1 0.768364238349883 1 Inf 12.687987818897 Inf 2.72938067891301e-10 54 1830 True False Inf 12.687987818897 Inf 0.00317532320254025 0.00173703251080297 0.00532191922970533 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 11 11 0 11 0 3775 16046 0.00290544109878499 0.00145125037710396 0.0051926765025673 1 0.999770132403032 1 1 0.715085847081845 1 1 0.715085847081845 1 1 0.715085847081845 1 Inf 10.6608738336509 Inf 1.21295522163799e-08 61 1762 True False 0 0 0 0 0 0 0 Inf 10.6608738336509 Inf 0.00290544109878499 0.00145125037710396 0.0051926765025673 1 0.999770132403032 1 74 Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Asp8fs pncA_p.Asp8fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Asp8Glu pncA_p.Asp8Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 9 0 9 0 4400 16822 0.00204127920163302 0.000933814369660709 0.00387143149170671 1 0.999780735048249 1 1 0.663732883120057 1 1 0.663732883120057 1 1 0.663732883120057 1 Inf 7.54177743415507 Inf 7.13698843528946e-07 90.5 1830 True False Inf 7.54177743415507 Inf 0.00204127920163302 0.000933814369660709 0.00387143149170671 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 7 7 0 7 0 3779 16046 0.00184891706286318 0.000743673531480306 0.00380574231364529 1 0.999770132403032 1 1 0.590383602774996 1 1 0.590383602774996 1 1 0.590383602774996 1 Inf 6.11594331475081 Inf 9.19916249305378e-06 102.5 1762 True False 0 0 0 0 0 0 0 Inf 6.11594331475081 Inf 0.00184891706286318 0.000743673531480306 0.00380574231364529 1 0.999770132403032 1 27 Assoc w RI 1) Assoc w R UP from AwRI to AwR yes 4 +Pyrazinamide pncA p.Asp8Gly pncA_p.Asp8Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 23 22 1 22 1 4387 16821 0.00498979360399183 0.00312963962508212 0.00754491629562881 0.99994055403638 0.999668833292177 0.99999849495964 0.956521739130434 0.780513392546519 0.998899831369558 0.956521739130434 0.780513392546519 0.998899831369558 0.956521739130434 0.780513392546519 0.998899831369558 84.3542284020971 13.6237359214741 3414.77096921891 1.6984392464012e-14 39 1830 True False 84.3542284020971 13.6237359214741 3414.77096921891 0.00498979360399183 0.00312963962508212 0.00754491629562881 0.99994055403638 0.999668833292177 0.99999849495964 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 21 20 1 20 1 3766 16045 0.00528262017960908 0.00322965810863289 0.00814684323786685 0.999937679172379 0.999652820032955 0.999998422174497 0.952380952380952 0.761840090063179 0.998795116551636 0.952380952380952 0.761840090063179 0.998795116551636 0.952380952380952 0.761840090063179 0.998795116551636 85.2097716409984 13.6160769076237 3462.6517334438 6.82489691027587e-14 37 1762 True False 0 0 0 0 0 0 0 85.2097716409984 13.6160769076237 3462.6517334438 0.00528262017960908 0.00322965810863289 0.00814684323786685 0.999937679172379 0.999652820032955 0.999998422174497 21 Assoc w R Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Asp8His pncA_p.Asp8His 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.716637886286628 Inf 0.0431182613129385 265.5 1830 False False Inf 0.716637886286628 Inf 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 2 2 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.796077158748321 Inf 0.0364363919492442 248 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 7 2) Assoc w R - Interim UP from Uncertain to AwRI yes 4 +Pyrazinamide pncA p.Asp8Tyr pncA_p.Asp8Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.716800488047171 Inf 0.0431027624717359 243 1830 False False Inf 1.57702975056642 Inf 0.000453720508166969 5.49523823434802e-05 0.00163802343880428 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 2 2 0 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.796287283318118 Inf 0.0364208169216465 224.5 1762 False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf 0.000528401585204755 6.39982904626514e-05 0.00190745126237675 1 0.999770132403032 1 1 2) Assoc w R - Interim UP from Uncertain to AwRI yes 4 +Pyrazinamide pncA p.Cys138Arg pncA_p.Cys138Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 9 0 9 0 4400 16822 0.00204127920163302 0.000933814369660709 0.00387143149170671 1 0.999780735048249 1 1 0.663732883120057 1 1 0.663732883120057 1 1 0.663732883120057 1 Inf 7.54177743415507 Inf 7.13698843528946e-07 90.5 1830 True False Inf 7.54177743415507 Inf 0.00204127920163302 0.000933814369660709 0.00387143149170671 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 9 9 0 9 0 3777 16046 0.00237717908082408 0.00108755584228183 0.00450780893694816 1 0.999770132403032 1 1 0.663732883120057 1 1 0.663732883120057 1 1 0.663732883120057 1 Inf 8.37964612204265 Inf 3.34181689819727e-07 76.5 1762 True False 0 0 0 0 0 0 0 Inf 8.37964612204265 Inf 0.00237717908082408 0.00108755584228183 0.00450780893694816 1 0.999770132403032 1 25 Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Cys138Ser pncA_p.Cys138Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA p.Cys14Arg pncA_p.Cys14Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 43 42 1 42 1 4367 16821 0.00952596960762077 0.00687386273288133 0.012854748172689 0.99994055403638 0.999668833292177 0.99999849495964 0.976744186046511 0.87710951729866 0.999411387068406 0.976744186046511 0.87710951729866 0.999411387068406 0.976744186046511 0.87710951729866 0.999411387068406 161.777421570872 27.4662356414363 6280.47901860916 6.27944589526961e-28 17 1830 True False 161.777421570872 27.4662356414363 6280.47901860916 0.00952596960762077 0.00687386273288133 0.012854748172689 0.99994055403638 0.999668833292177 0.99999849495964 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 30 29 1 29 1 3757 16045 0.00765979926043317 0.0051357154136685 0.0109823600342142 0.999937679172379 0.999652820032955 0.999998422174497 0.966666666666666 0.827830544366587 0.999156429073369 0.966666666666666 0.827830544366587 0.999156429073369 0.966666666666666 0.827830544366587 0.999156429073369 123.850146393399 20.5079342642907 4908.91577495604 3.12570142625005e-20 23 1762 True False 0 0 0 0 0 0 0 123.850146393399 20.5079342642907 4908.91577495604 0.00765979926043317 0.0051357154136685 0.0109823600342142 0.999937679172379 0.999652820032955 0.999998422174497 242 Assoc w R Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Cys14Gly pncA_p.Cys14Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 19 7 12 8 12 4401 16810 0.00181447040145157 0.000783674794110066 0.0035720830153558 0.999286648436571 0.998754250286254 0.999631348241016 0.4 0.191190060725307 0.63945741269251 0.368421052631578 0.162885872155099 0.616422076685594 0.368421052631578 0.162885872155099 0.616422076685594 2.22809210028023 0.742704418435465 6.14213169533197 0.0920152350732783 300 1830 False False 2.54639097174884 0.902247757047057 6.77898639956393 0.00158802177858439 0.000638697975897407 0.00326917752821328 0.999286648436571 0.998754250286254 0.999631348241016 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 17 7 10 8 10 3778 16036 0.00211304807184363 0.00091269178353604 0.00415927925423806 0.999376791723794 0.998854197426924 0.999701108243012 0.444444444444444 0.215301507387299 0.692428341001244 0.411764705882352 0.184436961783946 0.670752846053242 0.411764705882352 0.184436961783946 0.670752846053242 2.97120169401799 0.959165125157186 8.65284523208394 0.029722809221743 219 1762 False False 0 0 0 0 0 0 0 3.39565907887771 1.16365912839472 9.56436590680248 0.00184940554821664 0.000743870093390834 0.00380674680736097 0.999376791723794 0.998854197426924 0.999701108243012 43 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Cys14Phe pncA_p.Cys14Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA p.Cys14* pncA_p.Cys14* 1 stop_gained (see "Genomic_coordinates" sheet) 1 4 4 0 4 0 4405 16822 0.000907235200725788 0.000247244623732042 0.00232123869101376 1 0.999780735048249 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 2.51959224712996 Inf 0.00185784794966548 174 1830 True False Inf 2.51959224712996 Inf 0.000907235200725788 0.000247244623732042 0.00232123869101376 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 4 4 0 4 0 3782 16046 0.00105652403592181 0.000287939890647285 0.00270289202199999 1 0.999770132403032 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 2.79918348098377 Inf 0.0013264757267559 157.5 1762 True False 0 0 0 0 0 0 0 Inf 2.79918348098377 Inf 0.00105652403592181 0.000287939890647285 0.00270289202199999 1 0.999770132403032 1 10 Assoc w R Assoc w RI 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Cys14Trp pncA_p.Cys14Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 2 1 2 1 4407 16821 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.99994055403638 0.999668833292177 0.99999849495964 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 7.63376446562287 0.397281353658273 449.052313013199 0.111452652175084 308.5 1830 False False 7.63376446562287 0.397281353658273 449.052313013199 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.99994055403638 0.999668833292177 0.99999849495964 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 3 2 1 2 1 3784 16045 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999937679172379 0.999652820032955 0.999998422174497 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 8.48044397463002 0.441282441622781 498.676520130596 0.0954034464341229 286.5 1762 False False 0 0 0 0 0 0 0 8.48044397463002 0.441282441622781 498.676520130596 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999937679172379 0.999652820032955 0.999998422174497 5 2) Assoc w R - Interim UP from Uncertain to AwRI yes 4 +Pyrazinamide pncA p.Cys14Tyr pncA_p.Cys14Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 14 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA p.Cys72Arg pncA_p.Cys72Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 14 14 0 14 0 4395 16822 0.00317532320254025 0.00173703251080297 0.00532191922970533 1 0.999780735048249 1 1 0.768364238349883 1 1 0.768364238349883 1 1 0.768364238349883 1 Inf 12.687987818897 Inf 2.72938067891301e-10 54 1830 True False Inf 12.687987818897 Inf 0.00317532320254025 0.00173703251080297 0.00532191922970533 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 12 12 0 12 0 3774 16046 0.00316957210776545 0.00163880353722015 0.00553005230777549 1 0.999770132403032 1 1 0.735351530602948 1 1 0.735351530602948 1 1 0.735351530602948 1 Inf 11.8050954092125 Inf 2.31012863209904e-09 55.5 1762 True False 0 0 0 0 0 0 0 Inf 11.8050954092125 Inf 0.00316957210776545 0.00163880353722015 0.00553005230777549 1 0.999770132403032 1 10 Assoc w R Assoc w RI 1) Assoc w R UP from AwRI to AwR yes 4 +Pyrazinamide pncA p.Cys72Phe pncA_p.Cys72Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 5 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA p.Cys72Trp pncA_p.Cys72Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Cys72Tyr pncA_p.Cys72Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.716637886286628 Inf 0.0431182613129385 265.5 1830 False False Inf 0.716637886286628 Inf 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 2 2 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.796077158748321 Inf 0.0364363919492442 248 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 6 Assoc w RI 2) Assoc w R - Interim No change yes 1 +Pyrazinamide pncA p.Gln10Arg pncA_p.Gln10Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 56 53 3 57 3 4352 16819 0.0129281016103424 0.0098059249321282 0.0167177892343912 0.999821662109142 0.999478910338162 0.999963220929399 0.95 0.860756753278927 0.989567670355651 0.946428571428571 0.851325549052808 0.988813029165825 0.946428571428571 0.851325549052808 0.988813029165825 68.2756587009803 22.1088578407959 339.406977038562 7.00018002427845e-33 10 1830 True False 73.4285386029411 23.8569781192829 365.019637844216 0.0120317820658342 0.00902526382574117 0.0157086557924241 0.999821662109142 0.999478910338162 0.999963220929399 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 15 14 1 18 1 3768 16045 0.00475435816164817 0.00282009453029678 0.0075035659656758 0.999937679172379 0.999652820032955 0.999998422174497 0.947368421052631 0.739719345804785 0.99866837119582 0.933333333333333 0.680515433421696 0.998313569758647 0.933333333333333 0.680515433421696 0.998313569758647 59.6151804670912 9.06302438234895 2486.71384377584 1.02084584375587e-09 53 1762 True False 0 0 0 0 0 0 0 76.6480891719745 12.0909439707651 3137.68218558754 0.00370174510840824 0.00202521091994035 0.00620310704687446 0.999937679172379 0.999652820032955 0.999998422174497 159 Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Gln10His pncA_p.Gln10His 1 missense_variant (see "Genomic_coordinates" sheet) 1 13 13 0 14 0 4395 16822 0.00317532320254025 0.00173703251080297 0.00532191922970533 1 0.999780735048249 1 1 0.768364238349883 1 1 0.752947361999529 1 1 0.752947361999529 1 Inf 11.6576731589126 Inf 1.31429986831486e-09 58 1830 True False Inf 12.687987818897 Inf 0.00294918330308529 0.00157122145379172 0.00503791308918907 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 12 12 0 13 0 3773 16046 0.0034337031167459 0.00182953006918454 0.00586457926930979 1 0.999770132403032 1 1 0.752947361999529 1 1 0.735351530602948 1 1 0.735351530602948 1 Inf 11.8082219206616 Inf 2.30420074481702e-09 54 1762 True False 0 0 0 0 0 0 0 Inf 12.9516379657707 Inf 0.00317040951122853 0.00163923678543461 0.00553151162049234 1 0.999770132403032 1 9 Assoc w RI 1) Assoc w R UP from AwRI to AwR yes 4 +Pyrazinamide pncA p.Gln10Leu pncA_p.Gln10Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA p.Gln10Lys pncA_p.Gln10Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA p.Gln10Pro pncA_p.Gln10Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 74 69 5 70 5 4339 16817 0.0158766160127012 0.0123969625215667 0.0200170972699385 0.999702770181904 0.999306502227134 0.999903483469113 0.933333333333333 0.851239520842217 0.978000747530204 0.932432432432432 0.849321271456921 0.977698487670764 0.932432432432432 0.849321271456921 0.977698487670764 53.4857340401014 21.824927065897 170.483176457276 2.66428599617628e-41 6 1830 True False 54.2608896058999 22.1544807149671 172.62926410692 0.0156533575317604 0.0121991230672174 0.0197690512681415 0.999702770181904 0.999306502227134 0.999903483469113 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 64 61 3 61 3 3725 16043 0.0161119915478077 0.0123462259435238 0.0206489729197736 0.999813037517138 0.999453714469566 0.999961442181588 0.953125 0.869064262758594 0.990226925045543 0.953125 0.869064262758594 0.990226925045543 0.953125 0.869064262758594 0.990226925045543 87.5725279642058 28.5474585495614 436.022071765995 2.04821303899919e-40 5 1762 True False 0 0 0 0 0 0 0 87.5725279642058 28.5474585495614 436.022071765995 0.0161119915478077 0.0123462259435238 0.0206489729197736 0.999813037517138 0.999453714469566 0.999961442181588 121 Assoc w R Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Gln10* pncA_p.Gln10* 1 stop_gained (see "Genomic_coordinates" sheet) 1 7 7 0 7 0 4402 16822 0.00158766160127012 0.000638553061192671 0.00326843667440656 1 0.999780735048249 1 1 0.590383602774996 1 1 0.590383602774996 1 1 0.590383602774996 1 Inf 5.50478416804174 Inf 1.65938667095456e-05 115.5 1830 True False Inf 5.50478416804174 Inf 0.00158766160127012 0.000638553061192671 0.00326843667440656 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 5 5 0 5 0 3781 16046 0.00132065504490227 0.000428947757354115 0.0030792549559865 1 0.999770132403032 1 1 0.478176249895018 1 1 0.478176249895018 1 1 0.478176249895018 1 Inf 3.88652681138742 Inf 0.000253012467147004 128 1762 True False 0 0 0 0 0 0 0 Inf 3.88652681138742 Inf 0.00132065504490227 0.000428947757354115 0.0030792549559865 1 0.999770132403032 1 11 Assoc w R Assoc w RI 1) Assoc w R UP from AwRI to AwR yes 4 +Pyrazinamide pncA p.Gln122fs pncA_p.Gln122fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Gln122* pncA_p.Gln122* 1 stop_gained (see "Genomic_coordinates" sheet) 1 9 9 0 11 0 4398 16822 0.00249489680199591 0.00124608094986302 0.0044596646631454 1 0.999780735048249 1 1 0.715085847081845 1 1 0.663732883120057 1 1 0.663732883120057 1 Inf 7.54520244087316 Inf 7.11390785817754e-07 84 1830 True False Inf 9.59317044611859 Inf 0.00204220558202859 0.000934238343534958 0.00387318682554203 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 8 8 0 8 0 3778 16046 0.00211304807184363 0.00091269178353604 0.00415927925423806 1 0.999770132403032 1 1 0.63058335244718 1 1 0.63058335244718 1 1 0.63058335244718 1 Inf 7.24385478693174 Inf 1.75352509766709e-06 91 1762 True False 0 0 0 0 0 0 0 Inf 7.24385478693174 Inf 0.00211304807184363 0.00091269178353604 0.00415927925423806 1 0.999770132403032 1 4 Assoc w R Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Gln141Pro pncA_p.Gln141Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 80 75 5 75 5 4334 16817 0.0170106600136085 0.0134028618723983 0.0212769097587408 0.999702770181904 0.999306502227134 0.999903483469113 0.9375 0.860142924702361 0.979396927697989 0.9375 0.860142924702361 0.979396927697989 0.9375 0.860142924702361 0.979396927697989 58.203737886479 23.8383925924265 185.373120773032 2.98648789621177e-45 5 1830 True False 58.203737886479 23.8383925924265 185.373120773032 0.0170106600136085 0.0134028618723983 0.0212769097587408 0.999702770181904 0.999306502227134 0.999903483469113 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 78 73 5 73 5 3713 16041 0.0192815636555731 0.0151433548792672 0.0241833395118832 0.999688395861897 0.99927297097682 0.999898815491092 0.935897435897436 0.856712403893114 0.978860279588538 0.935897435897436 0.856712403893114 0.978860279588538 0.935897435897436 0.856712403893114 0.978860279588538 63.0753029894963 25.7904567958117 200.2636040667 1.35811954624099e-46 4 1762 True False 0 0 0 0 0 0 0 63.0753029894963 25.7904567958117 200.2636040667 0.0192815636555731 0.0151433548792672 0.0241833395118832 0.999688395861897 0.99927297097682 0.999898815491092 121 Assoc w R Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Gln141* pncA_p.Gln141* 1 stop_gained (see "Genomic_coordinates" sheet) 1 6 6 0 7 0 4402 16822 0.00158766160127012 0.000638553061192671 0.00326843667440656 1 0.999780735048249 1 1 0.590383602774996 1 1 0.540741873560099 1 1 0.540741873560099 1 Inf 4.49729646062438 Inf 7.99057346587355e-05 123.5 1830 True False Inf 5.50478416804174 Inf 0.0013611615245009 0.000499680922216912 0.00296030374676177 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 6 6 0 7 0 3779 16046 0.00184891706286318 0.000743673531480306 0.00380574231364529 1 0.999770132403032 1 1 0.590383602774996 1 1 0.540741873560099 1 1 0.540741873560099 1 Inf 4.99598460361806 Inf 4.81874776973699e-05 109 1762 True False 0 0 0 0 0 0 0 Inf 6.11594331475081 Inf 0.00158520475561426 0.00058195737791826 0.00344710660170385 1 0.999770132403032 1 19 Assoc w R Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Glu107del pncA_p.Glu107del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Pyrazinamide pncA p.Glu107Gly pncA_p.Glu107Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA p.Glu107* pncA_p.Glu107* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 Assoc w R Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Glu111* pncA_p.Glu111* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 NA Assoc w R Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Glu127_Asp129del pncA_p.Glu127_Asp129del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 10 10 0 11 0 4398 16822 0.00249489680199591 0.00124608094986302 0.0044596646631454 1 0.999780735048249 1 1 0.715085847081845 1 1 0.691502892181239 1 1 0.691502892181239 1 Inf 8.56952446348973 Inf 1.47706574841481e-07 74 1830 True False Inf 9.59317044611859 Inf 0.00226860254083484 0.00108840241403571 0.00416807067843688 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 5 5 0 6 0 3780 16046 0.00158478605388272 0.000581803608073282 0.0034461969631646 1 0.999770132403032 1 1 0.540741873560099 1 1 0.478176249895018 1 1 0.478176249895018 1 Inf 3.88755436913212 Inf 0.000252742045721707 122 1762 True False 0 0 0 0 0 0 0 Inf 4.99466385094306 Inf 0.00132100396301188 0.000429061121297529 0.00308006778073064 1 0.999770132403032 1 8 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Glu144fs pncA_p.Glu144fs 1 frameshift (see "Genomic_coordinates" sheet) 1 9 9 0 9 0 4400 16822 0.00204127920163302 0.000933814369660709 0.00387143149170671 1 0.999780735048249 1 1 0.663732883120057 1 1 0.663732883120057 1 1 0.663732883120057 1 Inf 7.54177743415507 Inf 7.13698843528946e-07 90.5 1830 True False Inf 7.54177743415507 Inf 0.00204127920163302 0.000933814369660709 0.00387143149170671 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 9 9 0 9 0 3777 16046 0.00237717908082408 0.00108755584228183 0.00450780893694816 1 0.999770132403032 1 1 0.663732883120057 1 1 0.663732883120057 1 1 0.663732883120057 1 Inf 8.37964612204265 Inf 3.34181689819727e-07 76.5 1762 True False 0 0 0 0 0 0 0 Inf 8.37964612204265 Inf 0.00237717908082408 0.00108755584228183 0.00450780893694816 1 0.999770132403032 1 3 1) Assoc w R UP from AwRI to AwR yes 4 +Pyrazinamide pncA p.Glu144* pncA_p.Glu144* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 NA Assoc w R Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Glu15fs pncA_p.Glu15fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 4 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Glu15Gly pncA_p.Glu15Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.23555131695149 1 1273 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 4) Not assoc w R - Interim WHO 4) Not assoc w R - interim 1 3 0 3 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 10.2590571436125 1 554.5 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 7 Not assoc w RI 4) Not assoc w R - Interim No change yes 1 +Pyrazinamide pncA p.Glu15* pncA_p.Glu15* 1 stop_gained (see "Genomic_coordinates" sheet) 1 3 1 2 2 2 4407 16820 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.999881108072762 0.999570588169705 0.999985601311719 0.5 0.067585986488543 0.932414013511457 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 1.90832766054005 0.0323387668486046 36.671823741687 0.502530085826874 520.5 1830 False False 3.8166553210801 0.276553001924986 52.6392074577436 0.000226860254083484 5.74358785768897e-06 0.0012633291757201 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 3785 16044 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999875358344758 0.999549824781286 0.999984904960856 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5768265057825 1 927 1762 False False 0 0 0 0 0 0 0 2.11941875825627 0.0359146288488272 40.7195918479678 0 0 0.000974130102511011 0.999875358344758 0.999549824781286 0.999984904960856 1 Assoc w R Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Glu173fs pncA_p.Glu173fs 1 frameshift (see "Genomic_coordinates" sheet) 1 37 37 0 37 0 4372 16822 0.00839192560671354 0.00591537596272904 0.0115487824128753 1 0.999780735048249 1 1 0.90510941258501 1 1 0.90510941258501 1 1 0.90510941258501 1 Inf 36.6351308848934 Inf 4.90370460726397e-26 19 1830 True False Inf 36.6351308848934 Inf 0.00839192560671354 0.00591537596272904 0.0115487824128753 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 25 25 0 25 0 3761 16046 0.00660327522451135 0.0042777162234936 0.00973240329086289 1 0.999770132403032 1 1 0.862814828469287 1 1 0.862814828469287 1 1 0.862814828469287 1 Inf 26.8072881320579 Inf 9.82736396845704e-19 25 1762 True False 0 0 0 0 0 0 0 Inf 26.8072881320579 Inf 0.00660327522451135 0.0042777162234936 0.00973240329086289 1 0.999770132403032 1 360 1) Assoc w R UP from AwRI to AwR yes 4 +Pyrazinamide pncA p.Glu173* pncA_p.Glu173* 1 stop_gained (see "Genomic_coordinates" sheet) 1 3 3 0 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 1.57702975056642 Inf 0.00895106588186537 214 1830 False False Inf 1.57702975056642 Inf 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 3 3 0 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 1.75196919627044 Inf 0.00695286470680484 189.5 1762 False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 NA Assoc w R 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Glu174Asp pncA_p.Glu174Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1328 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1276 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Glu174* pncA_p.Glu174* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 4 Assoc w R Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Glu181fs pncA_p.Glu181fs 1 frameshift (see "Genomic_coordinates" sheet) 1 3 1 2 1 2 4408 16820 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999881108072762 0.999570588169705 0.999985601311719 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 1.9078947368421 0.0323314320919459 36.6634061310851 0.502600379724595 526 1830 False False 1.9078947368421 0.0323314320919459 36.6634061310851 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 3785 16045 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 4.23910171730515 0.0539892730999128 331.863925136224 0.345370788365398 466.5 1762 False False 0 0 0 0 0 0 0 4.23910171730515 0.0539892730999128 331.863925136224 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 4 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Glu181* pncA_p.Glu181* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 2 Assoc w R Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Glu37Ala pncA_p.Glu37Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA p.Glu37fs pncA_p.Glu37fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 4 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Glu37Val pncA_p.Glu37Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA p.Glu91* pncA_p.Glu91* 1 stop_gained (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.716637886286628 Inf 0.0431182613129385 265.5 1830 False False Inf 0.716637886286628 Inf 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 8 Assoc w R Assoc w RI 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Gly101* pncA_p.Gly101* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 Assoc w R Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Gly105Asp pncA_p.Gly105Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 6 2 6 2 4403 16820 0.00136085280108868 0.000499567554195151 0.00295963286153356 0.999881108072762 0.999570588169705 0.999985601311719 0.75 0.349144205587175 0.968145973750055 0.75 0.349144205587175 0.968145973750055 0.75 0.349144205587175 0.968145973750055 11.4603679309561 2.04817323907972 116.208277323028 0.00151554594863308 162 1830 True False 11.4603679309561 2.04817323907972 116.208277323028 0.00136085280108868 0.000499567554195151 0.00295963286153356 0.999881108072762 0.999570588169705 0.999985601311719 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 8 6 2 6 2 3780 16044 0.00158478605388272 0.000581803608073282 0.0034461969631646 0.999875358344758 0.999549824781286 0.999984904960856 0.75 0.349144205587175 0.968145973750055 0.75 0.349144205587175 0.968145973750055 0.75 0.349144205587175 0.968145973750055 12.7333333333333 2.27524901217992 129.190351757936 0.000946246416919865 138.5 1762 True False 0 0 0 0 0 0 0 12.7333333333333 2.27524901217992 129.190351757936 0.00158478605388272 0.000581803608073282 0.0034461969631646 0.999875358344758 0.999549824781286 0.999984904960856 22 Assoc w RI 1) Assoc w R UP from AwRI to AwR yes 4 +Pyrazinamide pncA p.Gly105Ser pncA_p.Gly105Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA p.Gly105Val pncA_p.Gly105Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 4 0 4 0 4405 16822 0.000907235200725788 0.000247244623732042 0.00232123869101376 1 0.999780735048249 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 2.51959224712996 Inf 0.00185784794966548 174 1830 True False Inf 2.51959224712996 Inf 0.000907235200725788 0.000247244623732042 0.00232123869101376 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 4 4 0 4 0 3782 16046 0.00105652403592181 0.000287939890647285 0.00270289202199999 1 0.999770132403032 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 2.79918348098377 Inf 0.0013264757267559 157.5 1762 True False 0 0 0 0 0 0 0 Inf 2.79918348098377 Inf 0.00105652403592181 0.000287939890647285 0.00270289202199999 1 0.999770132403032 1 17 Assoc w R 2) Assoc w R - Interim DOWN from AwR to AwRI yes 3 +Pyrazinamide pncA p.Gly108Arg pncA_p.Gly108Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 18 17 1 17 1 4392 16821 0.00385574960308459 0.00224767150840848 0.00616627368860949 0.99994055403638 0.999668833292177 0.99999849495964 0.944444444444444 0.727056400326631 0.99859444383263 0.944444444444444 0.727056400326631 0.99859444383263 0.944444444444444 0.727056400326631 0.99859444383263 65.108606557377 10.1912763028629 2681.49644279063 3.51103703759145e-11 49 1830 True False 65.108606557377 10.1912763028629 2681.49644279063 0.00385574960308459 0.00224767150840848 0.00616627368860949 0.99994055403638 0.999668833292177 0.99999849495964 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 18 17 1 17 1 3769 16045 0.00449022715266772 0.00261783253916465 0.00717958501762183 0.999937679172379 0.999652820032955 0.999998422174497 0.944444444444444 0.727056400326631 0.99859444383263 0.944444444444444 0.727056400326631 0.99859444383263 0.944444444444444 0.727056400326631 0.99859444383263 72.3706553462456 11.3302583595815 2974.73563254031 8.52061825053994e-12 42 1762 True False 0 0 0 0 0 0 0 72.3706553462456 11.3302583595815 2974.73563254031 0.00449022715266772 0.00261783253916465 0.00717958501762183 0.999937679172379 0.999652820032955 0.999998422174497 29 Assoc w R Assoc w RI 1) Assoc w R UP from AwRI to AwR yes 4 +Pyrazinamide pncA p.Gly108Glu pncA_p.Gly108Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 4 0 4405 16822 0.000907235200725788 0.000247244623732042 0.00232123869101376 1 0.999780735048249 1 1 0.397635364383525 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.716963163599387 Inf 0.0430872649567619 240.5 1830 False False Inf 2.51959224712996 Inf 0.00045382346267302 5.49648527560197e-05 0.00163839490521339 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL 3) Uncertain significance 1 1 1 0 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 1 0.025 1 1 0.025 1 Inf 0.108730345524357 Inf 0.190821986888552 311 1762 False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf 0.000264270613107822 6.69073025551889e-06 0.00147153246904254 1 0.999770132403032 1 11 2) Assoc w R - Interim UP from Uncertain to AwRI yes 4 +Pyrazinamide pncA p.Gly113_Leu116delinsVal pncA_p.Gly113_Leu116delinsVal 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.23555131695149 1 1273 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 4) Not assoc w R - Interim WHO 4) Not assoc w R - interim 1 3 0 3 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 10.2590571436125 1 554.5 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 7 4) Not assoc w R - Interim SWITCH from AwRI to NotAwRI yes 6 +Pyrazinamide pncA p.Gly124Ser pncA_p.Gly124Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Gly132_Thr135del pncA_p.Gly132_Thr135del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Pyrazinamide pncA p.Gly132Ala pncA_p.Gly132Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 58 56 2 57 2 4352 16820 0.0129281016103424 0.0098059249321282 0.0167177892343912 0.999881108072762 0.999570588169705 0.999985601311719 0.966101694915254 0.882851536111606 0.995868067027634 0.96551724137931 0.880922689119607 0.995796352760132 0.96551724137931 0.880922689119607 0.995796352760132 108.216911764705 28.5619664745169 938.846663488231 4.67574683506154e-36 8 1830 True False 110.149356617647 29.0964605884782 951.225709009183 0.0127041742286751 0.00961047826362529 0.0164660812357315 0.999881108072762 0.999570588169705 0.999985601311719 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 56 54 2 55 2 3731 16044 0.0145272054939249 0.0109621306778411 0.018867640683761 0.999875358344758 0.999549824781286 0.999984904960856 0.964912280701754 0.878929336803798 0.995722105059468 0.964285714285714 0.876868192542004 0.995645187258947 0.964285714285714 0.876868192542004 0.995645187258947 116.105065666041 30.5951954677706 990.381606778224 1.08378279386483e-36 6 1762 True False 0 0 0 0 0 0 0 118.255159474671 31.1856425024699 1003.78517031146 0.0142668428005284 0.0107353797751978 0.0185745825780294 0.999875358344758 0.999549824781286 0.999984904960856 329 Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Gly132Arg pncA_p.Gly132Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1336 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1284 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 2 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Gly132Asp pncA_p.Gly132Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.716637886286628 Inf 0.0431182613129385 265.5 1830 False False Inf 0.716637886286628 Inf 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 2 2 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.796077158748321 Inf 0.0364363919492442 248 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 34 Assoc w RI 2) Assoc w R - Interim No change yes 1 +Pyrazinamide pncA p.Gly132Cys pncA_p.Gly132Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.716637886286628 Inf 0.0431182613129385 265.5 1830 False False Inf 0.716637886286628 Inf 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 2 2 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.796077158748321 Inf 0.0364363919492442 248 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 NA 2) Assoc w R - Interim UP from Uncertain to AwRI yes 4 +Pyrazinamide pncA p.Gly132fs pncA_p.Gly132fs 1 frameshift (see "Genomic_coordinates" sheet) 1 4 4 0 4 1 4405 16821 0.000907235200725788 0.000247244623732042 0.00232123869101376 0.99994055403638 0.999668833292177 0.99999849495964 0.8 0.28358206388191 0.994949236620532 1 0.397635364383525 1 0.8 0.28358206388191 0.994949236620532 Inf 2.51944246508696 Inf 0.00185819804114325 184 1830 True False 15.2744608399545 1.5107888308703 749.051486258063 0.000907235200725788 0.000247244623732042 0.00232123869101376 0.99994055403638 0.999668833292177 0.99999849495964 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 3 3 0 3 1 3783 16045 0.000792393026941363 0.000163440311798119 0.00231394549068866 0.999937679172379 0.999652820032955 0.999998422174497 0.75 0.194120449683243 0.99369053679029 1 0.292401773821286 1 0.75 0.194120449683243 0.99369053679029 Inf 1.75185979976414 Inf 0.0069539166304581 201 1762 False False 0 0 0 0 0 0 0 12.7240285487708 1.02115021686679 665.307410149575 0.000792393026941363 0.000163440311798119 0.00231394549068866 0.999937679172379 0.999652820032955 0.999998422174497 33 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Gly132Ser pncA_p.Gly132Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 9 0 9 0 4400 16822 0.00204127920163302 0.000933814369660709 0.00387143149170671 1 0.999780735048249 1 1 0.663732883120057 1 1 0.663732883120057 1 1 0.663732883120057 1 Inf 7.54177743415507 Inf 7.13698843528946e-07 90.5 1830 True False Inf 7.54177743415507 Inf 0.00204127920163302 0.000933814369660709 0.00387143149170671 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 9 9 0 9 0 3777 16046 0.00237717908082408 0.00108755584228183 0.00450780893694816 1 0.999770132403032 1 1 0.663732883120057 1 1 0.663732883120057 1 1 0.663732883120057 1 Inf 8.37964612204265 Inf 3.34181689819727e-07 76.5 1762 True False 0 0 0 0 0 0 0 Inf 8.37964612204265 Inf 0.00237717908082408 0.00108755584228183 0.00450780893694816 1 0.999770132403032 1 16 Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Gly150_Leu151insAspAlaValArgAsnGly pncA_p.Gly150_Leu151insAspAlaValArgAsnGly 1 inframe_insertion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 16 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Pyrazinamide pncA p.Gly150fs pncA_p.Gly150fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 4408 16821 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1330 1830 False False 3.81601633393829 0.0486026416232846 298.829108180248 0 0 0.000836510060464794 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 3785 16045 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1278 1762 False False 0 0 0 0 0 0 0 4.23910171730515 0.0539892730999128 331.863925136224 0 0 0.000974130102511011 0.999937679172379 0.999652820032955 0.999998422174497 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Gly162Arg pncA_p.Gly162Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 4 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Gly162Asp pncA_p.Gly162Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 4 0 4 0 4405 16822 0.000907235200725788 0.000247244623732042 0.00232123869101376 1 0.999780735048249 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 2.51959224712996 Inf 0.00185784794966548 174 1830 True False Inf 2.51959224712996 Inf 0.000907235200725788 0.000247244623732042 0.00232123869101376 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 4 4 0 4 0 3782 16046 0.00105652403592181 0.000287939890647285 0.00270289202199999 1 0.999770132403032 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 2.79918348098377 Inf 0.0013264757267559 157.5 1762 True False 0 0 0 0 0 0 0 Inf 2.79918348098377 Inf 0.00105652403592181 0.000287939890647285 0.00270289202199999 1 0.999770132403032 1 10 Assoc w RI 2) Assoc w R - Interim No change yes 1 +Pyrazinamide pncA p.Gly162Ser pncA_p.Gly162Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA p.Gly17_Ala25del pncA_p.Gly17_Ala25del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Pyrazinamide pncA p.Gly17Ala pncA_p.Gly17Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 3 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Gly17Arg pncA_p.Gly17Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 NA 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Gly17Asp pncA_p.Gly17Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 4 1 4 1 4405 16821 0.000907235200725788 0.000247244623732042 0.00232123869101376 0.99994055403638 0.999668833292177 0.99999849495964 0.8 0.28358206388191 0.994949236620532 0.8 0.28358206388191 0.994949236620532 0.8 0.28358206388191 0.994949236620532 15.2744608399545 1.5107888308703 749.051486258063 0.00774708678874264 197 1830 False False 15.2744608399545 1.5107888308703 749.051486258063 0.000907235200725788 0.000247244623732042 0.00232123869101376 0.99994055403638 0.999668833292177 0.99999849495964 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 5 4 1 4 1 3782 16045 0.00105652403592181 0.000287939890647285 0.00270289202199999 0.999937679172379 0.999652820032955 0.999998422174497 0.8 0.28358206388191 0.994949236620532 0.8 0.28358206388191 0.994949236620532 0.8 0.28358206388191 0.994949236620532 16.9698572184029 1.67834059794994 831.753865754 0.00562032876519148 175.5 1762 False False 0 0 0 0 0 0 0 16.9698572184029 1.67834059794994 831.753865754 0.00105652403592181 0.000287939890647285 0.00270289202199999 0.999937679172379 0.999652820032955 0.999998422174497 24 Assoc w RI 2) Assoc w R - Interim No change yes 1 +Pyrazinamide pncA p.Gly17fs pncA_p.Gly17fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 4408 16821 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 3.81601633393829 0.0486026416232846 298.829108180248 0.372217803874758 506.5 1830 False False 3.81601633393829 0.0486026416232846 298.829108180248 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 3785 16045 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 4.23910171730515 0.0539892730999128 331.863925136224 0.345370788365398 466.5 1762 False False 0 0 0 0 0 0 0 4.23910171730515 0.0539892730999128 331.863925136224 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 3 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Gly17Ser pncA_p.Gly17Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 4 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA p.Gly17Val pncA_p.Gly17Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 4408 16821 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 3.81601633393829 0.0486026416232846 298.829108180248 0.372217803874758 506.5 1830 False False 3.81601633393829 0.0486026416232846 298.829108180248 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 3785 16045 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 4.23910171730515 0.0539892730999128 331.863925136224 0.345370788365398 466.5 1762 False False 0 0 0 0 0 0 0 4.23910171730515 0.0539892730999128 331.863925136224 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 3 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Gly23fs pncA_p.Gly23fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 3 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Gly24Asp pncA_p.Gly24Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 5 1 5 1 4404 16821 0.00113404400090723 0.000368320285107068 0.00264447958048867 0.99994055403638 0.999668833292177 0.99999849495964 0.833333333333333 0.358765421002325 0.99578925548551 0.833333333333333 0.358765421002325 0.99578925548551 0.833333333333333 0.358765421002325 0.99578925548551 19.0974114441416 2.13580486483461 898.821488982459 0.0019132693883777 189.5 1830 True False 19.0974114441416 2.13580486483461 898.821488982459 0.00113404400090723 0.000368320285107068 0.00264447958048867 0.99994055403638 0.999668833292177 0.99999849495964 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 6 5 1 5 1 3781 16045 0.00132065504490227 0.000428947757354115 0.0030792549559865 0.999937679172379 0.999652820032955 0.999998422174497 0.833333333333333 0.358765421002325 0.99578925548551 0.833333333333333 0.358765421002325 0.99578925548551 0.833333333333333 0.358765421002325 0.99578925548551 21.2179317640835 2.3726027647035 998.008782436883 0.00127682798332212 142 1762 True False 0 0 0 0 0 0 0 21.2179317640835 2.3726027647035 998.008782436883 0.00132065504490227 0.000428947757354115 0.0030792549559865 0.999937679172379 0.999652820032955 0.999998422174497 5 Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Gly24fs pncA_p.Gly24fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Gly24Val pncA_p.Gly24Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA p.Gly55del pncA_p.Gly55del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Pyrazinamide pncA p.Gly55fs pncA_p.Gly55fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.716637886286628 Inf 0.0431182613129385 265.5 1830 False False Inf 0.716637886286628 Inf 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 2 2 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.796077158748321 Inf 0.0364363919492442 248 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Gly60_Thr61del pncA_p.Gly60_Thr61del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Pyrazinamide pncA p.Gly78Asp pncA_p.Gly78Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 4 0 4 0 4405 16822 0.000907235200725788 0.000247244623732042 0.00232123869101376 1 0.999780735048249 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 2.51959224712996 Inf 0.00185784794966548 174 1830 True False Inf 2.51959224712996 Inf 0.000907235200725788 0.000247244623732042 0.00232123869101376 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 4 4 0 4 0 3782 16046 0.00105652403592181 0.000287939890647285 0.00270289202199999 1 0.999770132403032 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 2.79918348098377 Inf 0.0013264757267559 157.5 1762 True False 0 0 0 0 0 0 0 Inf 2.79918348098377 Inf 0.00105652403592181 0.000287939890647285 0.00270289202199999 1 0.999770132403032 1 7 2) Assoc w R - Interim UP from Uncertain to AwRI yes 4 +Pyrazinamide pncA p.Gly78Cys pncA_p.Gly78Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 4408 16821 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 3.81601633393829 0.0486026416232846 298.829108180248 0.372217803874758 506.5 1830 False False 3.81601633393829 0.0486026416232846 298.829108180248 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 3785 16045 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 4.23910171730515 0.0539892730999128 331.863925136224 0.345370788365398 466.5 1762 False False 0 0 0 0 0 0 0 4.23910171730515 0.0539892730999128 331.863925136224 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 7 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Gly78fs pncA_p.Gly78fs 1 frameshift (see "Genomic_coordinates" sheet) 1 3 1 2 1 2 4408 16820 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999881108072762 0.999570588169705 0.999985601311719 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 1.9078947368421 0.0323314320919459 36.6634061310851 0.502600379724595 526 1830 False False 1.9078947368421 0.0323314320919459 36.6634061310851 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 1 2 3785 16044 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999875358344758 0.999549824781286 0.999984904960856 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 2.11941875825627 0.0359146288488272 40.7195918479678 0.470354459331036 493.5 1762 False False 0 0 0 0 0 0 0 2.11941875825627 0.0359146288488272 40.7195918479678 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999875358344758 0.999549824781286 0.999984904960856 4 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Gly78Ser pncA_p.Gly78Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 3 2 3 2 4406 16820 0.000680426400544341 0.000140342268876931 0.00198719451371054 0.999881108072762 0.999570588169705 0.999985601311719 0.6 0.146632799634673 0.947255049473683 0.6 0.146632799634673 0.947255049473683 0.6 0.146632799634673 0.947255049473683 5.72628234226055 0.655677739135472 68.675028521871 0.0639561690130486 294 1830 False False 5.72628234226055 0.655677739135472 68.675028521871 0.000680426400544341 0.000140342268876931 0.00198719451371054 0.999881108072762 0.999570588169705 0.999985601311719 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 2 2 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.796077158748321 Inf 0.0364363919492442 248 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 5 2) Assoc w R - Interim UP from Uncertain to AwRI yes 4 +Pyrazinamide pncA p.Gly78Val pncA_p.Gly78Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 4 0 4405 16822 0.000907235200725788 0.000247244623732042 0.00232123869101376 1 0.999780735048249 1 1 0.397635364383525 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.716963163599387 Inf 0.0430872649567619 240.5 1830 False False Inf 2.51959224712996 Inf 0.00045382346267302 5.49648527560197e-05 0.00163839490521339 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 2 2 0 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.796287283318118 Inf 0.0364208169216465 224.5 1762 False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf 0.000528401585204755 6.39982904626514e-05 0.00190745126237675 1 0.999770132403032 1 10 2) Assoc w R - Interim UP from Uncertain to AwRI yes 4 +Pyrazinamide pncA p.Gly97Arg pncA_p.Gly97Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 7 0 10 0 4399 16822 0.00226808800181447 0.00108815543692413 0.00416712622349087 1 0.999780735048249 1 1 0.691502892181239 1 1 0.590383602774996 1 1 0.590383602774996 1 Inf 5.50853503147535 Inf 1.65312847133495e-05 112 1830 True False Inf 8.56754994230848 Inf 0.00158874262369496 0.000638988002720165 0.00327066024385542 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 7 7 0 10 0 3776 16046 0.00264131008980454 0.00126731492930415 0.00485208155788738 1 0.999770132403032 1 1 0.691502892181239 1 1 0.590383602774996 1 1 0.590383602774996 1 Inf 6.12086377675544 Inf 9.1579122088648e-06 100 1762 True False 0 0 0 0 0 0 0 Inf 9.51788812022163 Inf 0.00185038329368226 0.000744263529098951 0.00380875738639742 1 0.999770132403032 1 1 Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Gly97Asp pncA_p.Gly97Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 23 22 1 46 5 4363 16817 0.0104332048083465 0.00764825992334892 0.0138921635457812 0.999702770181904 0.999306502227134 0.999903483469113 0.901960784313725 0.785855017454319 0.967393510448109 0.956521739130434 0.780513392546519 0.998899831369558 0.814814814814814 0.619170120906005 0.936999993462323 84.7980747192298 13.6953423080559 3432.31694287846 1.55179472149596e-14 38 1830 True False 35.4610130644052 14.1269695742125 114.372456823733 0.00501710376282782 0.0031467829098526 0.00758615781305616 0.999702770181904 0.999306502227134 0.999903483469113 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 20 19 1 42 5 3744 16041 0.011093502377179 0.00800659410485929 0.0149658995007406 0.999688395861897 0.99927297097682 0.999898815491092 0.893617021276595 0.768952373249016 0.964543699192784 0.95 0.751267237227972 0.99873491050205 0.791666666666666 0.578487156362747 0.928681382801945 81.4046474358974 12.9316597945845 3319.32894927826 3.12881781585403e-13 40 1762 True False 0 0 0 0 0 0 0 35.989423076923 14.2404225608216 116.614095008833 0.00504916290193994 0.00304258098782633 0.00787371092670452 0.999688395861897 0.99927297097682 0.999898815491092 112 Assoc w R Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Gly97Cys pncA_p.Gly97Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 19 18 1 19 1 4390 16821 0.00430936720344749 0.0025964540708268 0.00672146538628393 0.99994055403638 0.999668833292177 0.99999849495964 0.95 0.751267237227972 0.99873491050205 0.947368421052631 0.739719345804785 0.99866837119582 0.947368421052631 0.739719345804785 0.99866837119582 68.9699316628701 10.8819422729696 2829.27688709552 7.64291988895131e-12 47 1830 True False 72.8015945330296 11.56429352145 2975.55031761603 0.00408348457350272 0.00242187269709156 0.00644601666777902 0.99994055403638 0.999668833292177 0.99999849495964 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 17 16 1 17 1 3769 16045 0.00449022715266772 0.00261783253916465 0.00717958501762183 0.999937679172379 0.999652820032955 0.999998422174497 0.944444444444444 0.727056400326631 0.99859444383263 0.941176470588235 0.713110603332779 0.998511825608733 0.941176470588235 0.713110603332779 0.998511825608733 68.1135579729371 10.5737289337593 2812.22086196882 4.21854199091494e-11 44 1762 True False 0 0 0 0 0 0 0 72.3706553462456 11.3302583595815 2974.73563254031 0.00422721268163804 0.00241808902127498 0.00685567466598668 0.999937679172379 0.999652820032955 0.999998422174497 19 Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Gly97fs pncA_p.Gly97fs 1 frameshift (see "Genomic_coordinates" sheet) 1 3 2 1 2 1 4407 16821 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.99994055403638 0.999668833292177 0.99999849495964 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 7.63376446562287 0.397281353658273 449.052313013199 0.111452652175084 308.5 1830 False False 7.63376446562287 0.397281353658273 449.052313013199 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.99994055403638 0.999668833292177 0.99999849495964 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 3 2 1 2 1 3784 16045 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999937679172379 0.999652820032955 0.999998422174497 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 8.48044397463002 0.441282441622781 498.676520130596 0.0954034464341229 286.5 1762 False False 0 0 0 0 0 0 0 8.48044397463002 0.441282441622781 498.676520130596 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999937679172379 0.999652820032955 0.999998422174497 3 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Gly97Ser pncA_p.Gly97Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 15 13 2 13 2 4396 16820 0.00294851440235881 0.00157086488136083 0.0050367716434693 0.999881108072762 0.999570588169705 0.999985601311719 0.866666666666666 0.595397303396627 0.983424086559916 0.866666666666666 0.595397303396627 0.983424086559916 0.866666666666666 0.595397303396627 0.983424086559916 24.8703366696997 5.62634296927153 226.091707178809 9.02468568341095e-08 72 1830 True False 24.8703366696997 5.62634296927153 226.091707178809 0.00294851440235881 0.00157086488136083 0.0050367716434693 0.999881108072762 0.999570588169705 0.999985601311719 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 11 10 1 10 1 3776 16045 0.00264131008980454 0.00126731492930415 0.00485208155788738 0.999937679172379 0.999652820032955 0.999998422174497 0.909090909090909 0.587220083011617 0.997701027786185 0.909090909090909 0.587220083011617 0.997701027786185 0.909090909090909 0.587220083011617 0.997701027786185 42.4920550847457 6.03925079441272 1826.07519384022 5.79115448271564e-07 84 1762 True False 0 0 0 0 0 0 0 42.4920550847457 6.03925079441272 1826.07519384022 0.00264131008980454 0.00126731492930415 0.00485208155788738 0.999937679172379 0.999652820032955 0.999998422174497 13 Assoc w R Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Gly97Val pncA_p.Gly97Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 3 0 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 1.57702975056642 Inf 0.00895106588186537 214 1830 False False Inf 1.57702975056642 Inf 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 3 3 0 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 1.75196919627044 Inf 0.00695286470680484 189.5 1762 False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 5 Assoc w RI 2) Assoc w R - Interim No change yes 1 +Pyrazinamide pncA p.His137Arg pncA_p.His137Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 2 5 2 5 4407 16817 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.999702770181904 0.999306502227134 0.999903483469113 0.285714285714285 0.0366925661760855 0.709579136262657 0.285714285714285 0.0366925661760855 0.709579136262657 0.285714285714285 0.0366925661760855 0.709579136262657 1.52638983435443 0.145279490817154 9.32731563324253 0.640289534516108 568.5 1830 False False 1.52638983435443 0.145279490817154 9.32731563324253 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.999702770181904 0.999306502227134 0.999903483469113 3) Uncertain significance 4) Not assoc w R - Interim WHO 4) Not assoc w R - interim 1 7 2 5 2 5 3784 16041 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999688395861897 0.99927297097682 0.999898815491092 0.285714285714285 0.0366925661760855 0.709579136262657 0.285714285714285 0.0366925661760855 0.709579136262657 0.285714285714285 0.0366925661760855 0.709579136262657 1.69566596194503 0.161390749261539 10.3624974670859 0.625054908394739 528 1762 False False 0 0 0 0 0 0 0 1.69566596194503 0.161390749261539 10.3624974670859 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999688395861897 0.99927297097682 0.999898815491092 14 4) Not assoc w R - Interim UP from Uncertain to NotAwRI yes 4 +Pyrazinamide pncA p.His137Asn pncA_p.His137Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 1 4408 16821 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0978242989491397 Inf 0.207677814413565 455 1830 False False 3.81601633393829 0.0486026416232846 298.829108180248 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 1 3785 16045 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.108666134732509 Inf 0.190913216680954 439 1762 False False 0 0 0 0 0 0 0 4.23910171730515 0.0539892730999128 331.863925136224 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 11 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.His137Gln pncA_p.His137Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 3 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.His137Pro pncA_p.His137Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 4 0 4 0 4405 16822 0.000907235200725788 0.000247244623732042 0.00232123869101376 1 0.999780735048249 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 2.51959224712996 Inf 0.00185784794966548 174 1830 True False Inf 2.51959224712996 Inf 0.000907235200725788 0.000247244623732042 0.00232123869101376 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 4 4 0 4 0 3782 16046 0.00105652403592181 0.000287939890647285 0.00270289202199999 1 0.999770132403032 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 2.79918348098377 Inf 0.0013264757267559 157.5 1762 True False 0 0 0 0 0 0 0 Inf 2.79918348098377 Inf 0.00105652403592181 0.000287939890647285 0.00270289202199999 1 0.999770132403032 1 5 2) Assoc w R - Interim UP from Uncertain to AwRI yes 4 +Pyrazinamide pncA p.His137Tyr pncA_p.His137Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.His42fs pncA_p.His42fs 1 frameshift (see "Genomic_coordinates" sheet) 1 4 4 0 4 0 4405 16822 0.000907235200725788 0.000247244623732042 0.00232123869101376 1 0.999780735048249 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 2.51959224712996 Inf 0.00185784794966548 174 1830 True False Inf 2.51959224712996 Inf 0.000907235200725788 0.000247244623732042 0.00232123869101376 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 4 4 0 4 0 3782 16046 0.00105652403592181 0.000287939890647285 0.00270289202199999 1 0.999770132403032 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 2.79918348098377 Inf 0.0013264757267559 157.5 1762 True False 0 0 0 0 0 0 0 Inf 2.79918348098377 Inf 0.00105652403592181 0.000287939890647285 0.00270289202199999 1 0.999770132403032 1 1 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.His43fs pncA_p.His43fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.His43Pro pncA_p.His43Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.716800488047171 Inf 0.0431027624717359 243 1830 False False Inf 1.57702975056642 Inf 0.000453720508166969 5.49523823434802e-05 0.00163802343880428 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL 3) Uncertain significance 1 1 1 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.108701618838585 Inf 0.190862790580404 314.5 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0.000264200792602377 6.68896256519433e-06 0.00147114392376758 1 0.999770132403032 1 5 2) Assoc w R - Interim UP from Uncertain to AwRI yes 4 +Pyrazinamide pncA p.His43Tyr pncA_p.His43Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.His51Arg pncA_p.His51Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 87 82 5 82 5 4327 16817 0.0185983216148786 0.0148184321699997 0.0230334708786714 0.999702770181904 0.999306502227134 0.999903483469113 0.942528735632184 0.870957543712074 0.98107810983103 0.942528735632184 0.870957543712074 0.98107810983103 0.942528735632184 0.870957543712074 0.98107810983103 63.7390339727293 26.2032860567999 201.738841036753 6.92520958382328e-50 4 1830 True False 63.7390339727293 26.2032860567999 201.738841036753 0.0185983216148786 0.0148184321699997 0.0230334708786714 0.999702770181904 0.999306502227134 0.999903483469113 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 14 13 1 13 1 3773 16045 0.0034337031167459 0.00182953006918454 0.00586457926930979 0.999937679172379 0.999652820032955 0.999998422174497 0.928571428571428 0.661315510068178 0.998193219340874 0.928571428571428 0.661315510068178 0.998193219340874 0.928571428571428 0.661315510068178 0.998193219340874 55.2835939570633 8.29679179515425 2320.00990633012 5.06968638258808e-09 57 1762 True False 0 0 0 0 0 0 0 55.2835939570633 8.29679179515425 2320.00990633012 0.0034337031167459 0.00182953006918454 0.00586457926930979 0.999937679172379 0.999652820032955 0.999998422174497 119 Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.His51Asp pncA_p.His51Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 49 48 1 48 1 4361 16821 0.0108868224087094 0.00803769007452386 0.0144087072823174 0.99994055403638 0.999668833292177 0.99999849495964 0.979591836734694 0.891458236031593 0.999483443502406 0.979591836734694 0.891458236031593 0.999483443502406 0.979591836734694 0.891458236031593 0.999483443502406 185.142857142857 31.6306799160886 7118.08655464932 5.46639544048944e-32 14 1830 True False 185.142857142857 31.6306799160886 7118.08655464932 0.0108868224087094 0.00803769007452386 0.0144087072823174 0.99994055403638 0.999668833292177 0.99999849495964 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 48 47 1 47 1 3739 16045 0.0124141574220813 0.00913532713452014 0.0164743503918647 0.999937679172379 0.999652820032955 0.999998422174497 0.979166666666666 0.889303839406847 0.999472684746576 0.979166666666666 0.889303839406847 0.999472684746576 0.979166666666666 0.889303839406847 0.999472684746576 201.688954265846 34.4431597256495 7717.74709146654 4.89570961808733e-33 9 1762 True False 0 0 0 0 0 0 0 201.688954265846 34.4431597256495 7717.74709146654 0.0124141574220813 0.00913532713452014 0.0164743503918647 0.999937679172379 0.999652820032955 0.999998422174497 65 Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.His51fs pncA_p.His51fs 1 frameshift (see "Genomic_coordinates" sheet) 1 4 4 0 4 0 4405 16822 0.000907235200725788 0.000247244623732042 0.00232123869101376 1 0.999780735048249 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 2.51959224712996 Inf 0.00185784794966548 174 1830 True False Inf 2.51959224712996 Inf 0.000907235200725788 0.000247244623732042 0.00232123869101376 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 3 3 0 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 1.75196919627044 Inf 0.00695286470680484 189.5 1762 False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 52 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.His51Gln pncA_p.His51Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 8 1 8 1 4401 16821 0.00181447040145157 0.000783674794110066 0.0035720830153558 0.99994055403638 0.999668833292177 0.99999849495964 0.888888888888888 0.517503485082663 0.9971908632534 0.888888888888888 0.517503485082663 0.9971908632534 0.888888888888888 0.517503485082663 0.9971908632534 30.5766871165644 4.09674326327108 1347.13599331235 2.52655228636597e-05 121 1830 True False 30.5766871165644 4.09674326327108 1347.13599331235 0.00181447040145157 0.000783674794110066 0.0035720830153558 0.99994055403638 0.999668833292177 0.99999849495964 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 8 7 1 7 1 3779 16045 0.00184891706286318 0.000743673531480306 0.00380574231364529 0.999937679172379 0.999652820032955 0.999998422174497 0.875 0.473490329124793 0.996840276468748 0.875 0.473490329124793 0.996840276468748 0.875 0.473490329124793 0.996840276468748 29.7208256152421 3.81564410496199 1329.90635130009 6.13186242607604e-05 118.5 1762 True False 0 0 0 0 0 0 0 29.7208256152421 3.81564410496199 1329.90635130009 0.00184891706286318 0.000743673531480306 0.00380574231364529 0.999937679172379 0.999652820032955 0.999998422174497 14 Assoc w R Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.His51Pro pncA_p.His51Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 8 0 8 0 4401 16822 0.00181447040145157 0.000783674794110066 0.0035720830153558 1 0.999780735048249 1 1 0.63058335244718 1 1 0.63058335244718 1 1 0.63058335244718 1 Inf 6.5206569685433 Inf 3.44167929021015e-06 103.5 1830 True False Inf 6.5206569685433 Inf 0.00181447040145157 0.000783674794110066 0.0035720830153558 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 8 8 0 8 0 3778 16046 0.00211304807184363 0.00091269178353604 0.00415927925423806 1 0.999770132403032 1 1 0.63058335244718 1 1 0.63058335244718 1 1 0.63058335244718 1 Inf 7.24385478693174 Inf 1.75352509766709e-06 91 1762 True False 0 0 0 0 0 0 0 Inf 7.24385478693174 Inf 0.00211304807184363 0.00091269178353604 0.00415927925423806 1 0.999770132403032 1 10 Assoc w RI 1) Assoc w R UP from AwRI to AwR yes 4 +Pyrazinamide pncA p.His51Tyr pncA_p.His51Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 5 0 5 0 4404 16822 0.00113404400090723 0.000368320285107068 0.00264447958048867 1 0.999780735048249 1 1 0.478176249895018 1 1 0.478176249895018 1 1 0.478176249895018 1 Inf 3.49836879238979 Inf 0.000385538239896191 148 1830 True False Inf 3.49836879238979 Inf 0.00113404400090723 0.000368320285107068 0.00264447958048867 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 5 5 0 5 0 3781 16046 0.00132065504490227 0.000428947757354115 0.0030792549559865 1 0.999770132403032 1 1 0.478176249895018 1 1 0.478176249895018 1 1 0.478176249895018 1 Inf 3.88652681138742 Inf 0.000253012467147004 128 1762 True False 0 0 0 0 0 0 0 Inf 3.88652681138742 Inf 0.00132065504490227 0.000428947757354115 0.0030792549559865 1 0.999770132403032 1 14 Assoc w RI 1) Assoc w R UP from AwRI to AwR yes 4 +Pyrazinamide pncA p.His57Arg pncA_p.His57Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 61 56 5 56 5 4353 16817 0.012701292810161 0.00960829536135841 0.0164623537043234 0.999702770181904 0.999306502227134 0.999903483469113 0.918032786885246 0.818988088890201 0.972848639604444 0.918032786885246 0.818988088890201 0.972848639604444 0.918032786885246 0.818988088890201 0.972848639604444 43.269101768895 17.4641535244217 138.442915140791 8.63959338983797e-33 11 1830 True False 43.269101768895 17.4641535244217 138.442915140791 0.012701292810161 0.00960829536135841 0.0164623537043234 0.999702770181904 0.999306502227134 0.999903483469113 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 59 54 5 54 5 3732 16041 0.0142630744849445 0.0107325395351345 0.0185696871845745 0.999688395861897 0.99927297097682 0.999898815491092 0.915254237288135 0.813205664528303 0.971908743279016 0.915254237288135 0.813205664528303 0.971908743279016 0.915254237288135 0.813205664528303 0.971908743279016 46.4209003215434 18.6948077054701 148.553023209095 1.9276689118633e-33 8 1762 True False 0 0 0 0 0 0 0 46.4209003215434 18.6948077054701 148.553023209095 0.0142630744849445 0.0107325395351345 0.0185696871845745 0.999688395861897 0.99927297097682 0.999898815491092 53 Assoc w R Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.His57Asp pncA_p.His57Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 163 161 2 166 2 4243 16820 0.0376502608301202 0.0322264371060261 0.0436969701365745 0.999881108072762 0.999570588169705 0.999985601311719 0.988095238095238 0.957659440932779 0.998555012494971 0.987730061349693 0.956381461656562 0.998510584019953 0.987730061349693 0.956381461656562 0.998510584019953 319.116191374027 86.842434953196 2720.40117042071 8.68225213586134e-108 2 1830 True False 329.026632099929 89.3539550229347 2814.62590807308 0.0365576748410535 0.0312106490097884 0.0425300026786005 0.999881108072762 0.999570588169705 0.999985601311719 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 161 159 2 164 2 3622 16044 0.0433174854727945 0.0370558632611871 0.0502957265417048 0.999875358344758 0.999549824781286 0.999984904960856 0.987951807228915 0.957157341064352 0.998537563014011 0.987577639751552 0.9558484076803619 0.998492038126603 0.987577639751552 0.9558484076803619 0.998492038126603 352.152954168967 95.7736590362493 3042.59709708925 2.1010772609107e-112 2 1762 True False 0 0 0 0 0 0 0 363.226946438431 98.6951845443766 3152.72399969509 0.0420523670986511 0.0358789728442284 0.0489455909561097 0.999875358344758 0.999549824781286 0.999984904960856 80 Assoc w R Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.His57fs pncA_p.His57fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.716637886286628 Inf 0.0431182613129385 265.5 1830 False False Inf 0.716637886286628 Inf 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 2 2 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.796077158748321 Inf 0.0364363919492442 248 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.His57Gln pncA_p.His57Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.716637886286628 Inf 0.0431182613129385 265.5 1830 False False Inf 0.716637886286628 Inf 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 2 2 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.796077158748321 Inf 0.0364363919492442 248 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 11 2) Assoc w R - Interim UP from Uncertain to AwRI yes 4 +Pyrazinamide pncA p.His57Leu pncA_p.His57Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 5 1 5 1 4404 16821 0.00113404400090723 0.000368320285107068 0.00264447958048867 0.99994055403638 0.999668833292177 0.99999849495964 0.833333333333333 0.358765421002325 0.99578925548551 0.833333333333333 0.358765421002325 0.99578925548551 0.833333333333333 0.358765421002325 0.99578925548551 19.0974114441416 2.13580486483461 898.821488982459 0.0019132693883777 189.5 1830 True False 19.0974114441416 2.13580486483461 898.821488982459 0.00113404400090723 0.000368320285107068 0.00264447958048867 0.99994055403638 0.999668833292177 0.99999849495964 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Evidence from ALL dataset only 2) Assoc w R - Interim New AwRI yes ALL only 5 +Pyrazinamide pncA p.His57Pro pncA_p.His57Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 7 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.His57Tyr pncA_p.His57Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 12 12 0 12 0 4397 16822 0.00272170560217736 0.00140711126319081 0.00474944049676375 1 0.999780735048249 1 1 0.735351530602948 1 1 0.735351530602948 1 1 0.735351530602948 1 Inf 10.6239097645824 Inf 6.35739683533611e-09 61 1830 True False Inf 10.6239097645824 Inf 0.00272170560217736 0.00140711126319081 0.00474944049676375 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 9 9 0 9 0 3777 16046 0.00237717908082408 0.00108755584228183 0.00450780893694816 1 0.999770132403032 1 1 0.663732883120057 1 1 0.663732883120057 1 1 0.663732883120057 1 Inf 8.37964612204265 Inf 3.34181689819727e-07 76.5 1762 True False 0 0 0 0 0 0 0 Inf 8.37964612204265 Inf 0.00237717908082408 0.00108755584228183 0.00450780893694816 1 0.999770132403032 1 15 Assoc w R Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.His71Arg pncA_p.His71Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 39 37 2 38 2 4371 16820 0.00861873440689498 0.00610614253181485 0.0118108737978286 0.999881108072762 0.999570588169705 0.999985601311719 0.95 0.830803136040582 0.993886353400649 0.948717948717948 0.826755218626394 0.993728027904309 0.948717948717948 0.826755218626394 0.993728027904309 71.1896591169068 18.3494560443178 608.887336221872 2.30538547311573e-23 21 1830 True False 73.1137039579043 18.8803431641759 624.752714264312 0.00839382940108893 0.00591671944799998 0.0115513981976275 0.999881108072762 0.999570588169705 0.999985601311719 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 39 37 2 38 2 3748 16044 0.0100369783412572 0.00711227904044182 0.0137507481996241 0.999875358344758 0.999549824781286 0.999984904960856 0.95 0.830803136040582 0.993886353400649 0.948717948717948 0.826755218626394 0.993728027904309 0.948717948717948 0.826755218626394 0.993728027904309 79.192636072572 20.4160882387827 678.404147627383 1.04096181760193e-24 15 1762 True False 0 0 0 0 0 0 0 81.3329775880469 21.0026968037904 695.111201492118 0.00977542932628798 0.00689188087324469 0.0134491957135486 0.999875358344758 0.999549824781286 0.999984904960856 52 Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.His71Gln pncA_p.His71Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 5 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.His71Pro pncA_p.His71Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 20 20 0 20 0 4389 16822 0.00453617600362894 0.00277294929564062 0.00699710319549207 1 0.999780735048249 1 1 0.831566529016914 1 1 0.831566529016914 1 1 0.831566529016914 1 Inf 18.9082936232782 Inf 2.15049156185091e-14 40.5 1830 True False Inf 18.9082936232782 Inf 0.00453617600362894 0.00277294929564062 0.00699710319549207 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 19 19 0 19 0 3767 16046 0.00501848917062863 0.00302408120608821 0.00782594556552751 1 0.999770132403032 1 1 0.823533088193034 1 1 0.823533088193034 1 1 0.823533088193034 1 Inf 19.8611544368769 Inf 2.08720983239118e-14 33 1762 True False 0 0 0 0 0 0 0 Inf 19.8611544368769 Inf 0.00501848917062863 0.00302408120608821 0.00782594556552751 1 0.999770132403032 1 29 Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.His71Tyr pncA_p.His71Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 36 34 2 34 2 4375 16820 0.00771149920616919 0.00534617862297411 0.0107595218761754 0.999881108072762 0.999570588169705 0.999985601311719 0.944444444444444 0.813363293542446 0.993199699345977 0.944444444444444 0.813363293542446 0.993199699345977 0.944444444444444 0.813363293542446 0.993199699345977 65.3577142857142 16.7407471983 560.803227409164 2.24721426798674e-21 26 1830 True False 65.3577142857142 16.7407471983 560.803227409164 0.00771149920616919 0.00534617862297411 0.0107595218761754 0.999881108072762 0.999570588169705 0.999985601311719 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 35 34 1 34 1 3752 16045 0.00898045430533544 0.00622701536814537 0.0125268703397902 0.999937679172379 0.999652820032955 0.999998422174497 0.971428571428571 0.850827920343568 0.999276895623662 0.971428571428571 0.850827920343568 0.999276895623662 0.971428571428571 0.850827920343568 0.999276895623662 145.397121535181 24.362248775163 5700.48390020308 8.93579741426694e-24 16 1762 True False 0 0 0 0 0 0 0 145.397121535181 24.362248775163 5700.48390020308 0.00898045430533544 0.00622701536814537 0.0125268703397902 0.999937679172379 0.999652820032955 0.999998422174497 100 Assoc w R Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.His82Arg pncA_p.His82Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 5 0 5 0 4404 16822 0.00113404400090723 0.000368320285107068 0.00264447958048867 1 0.999780735048249 1 1 0.478176249895018 1 1 0.478176249895018 1 1 0.478176249895018 1 Inf 3.49836879238979 Inf 0.000385538239896191 148 1830 True False Inf 3.49836879238979 Inf 0.00113404400090723 0.000368320285107068 0.00264447958048867 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 5 5 0 5 0 3781 16046 0.00132065504490227 0.000428947757354115 0.0030792549559865 1 0.999770132403032 1 1 0.478176249895018 1 1 0.478176249895018 1 1 0.478176249895018 1 Inf 3.88652681138742 Inf 0.000253012467147004 128 1762 True False 0 0 0 0 0 0 0 Inf 3.88652681138742 Inf 0.00132065504490227 0.000428947757354115 0.0030792549559865 1 0.999770132403032 1 32 Assoc w R Assoc w RI 1) Assoc w R UP from AwRI to AwR yes 4 +Pyrazinamide pncA p.His82Asp pncA_p.His82Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 2 6 2 6 4407 16816 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.999643324218285 0.999223829869625 0.999869095386533 0.25 0.0318540262499442 0.650855794412824 0.25 0.0318540262499442 0.650855794412824 0.25 0.0318540262499442 0.650855794412824 1.27191589138491 0.125530294636039 7.1172061789509 0.674282957967954 571 1830 False False 1.27191589138491 0.125530294636039 7.1172061789509 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.999643324218285 0.999223829869625 0.999869095386533 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 1 3 1 3 3785 16043 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999813037517138 0.999453714469566 0.999961442181588 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 1.41285777190664 0.0269058536042688 17.5998124179982 0.571480992034284 501.5 1762 False False 0 0 0 0 0 0 0 1.41285777190664 0.0269058536042688 17.5998124179982 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999813037517138 0.999453714469566 0.999961442181588 7 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Ile133Asn pncA_p.Ile133Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 4 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA p.Ile133fs pncA_p.Ile133fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.716637886286628 Inf 0.0431182613129385 265.5 1830 False False Inf 0.716637886286628 Inf 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 2 2 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.796077158748321 Inf 0.0364363919492442 248 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 34 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Ile133Ser pncA_p.Ile133Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Ile133Thr pncA_p.Ile133Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 47 29 18 29 18 4380 16804 0.00657745520526196 0.00440932038172428 0.00943276453464603 0.998929972654856 0.998309420654136 0.99936571457723 0.617021276595744 0.463799382891638 0.75493183098708 0.617021276595744 0.463799382891638 0.75493183098708 0.617021276595744 0.463799382891638 0.75493183098708 6.18107559614408 3.31467040241332 11.8319150468919 1.24325953432516e-09 57 1830 True False 6.18107559614408 3.31467040241332 11.8319150468919 0.00657745520526196 0.00440932038172428 0.00943276453464603 0.998929972654856 0.998309420654136 0.99936571457723 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 46 29 17 29 17 3757 16029 0.00765979926043317 0.0051357154136685 0.0109823600342142 0.99894054593045 0.998304251550396 0.999382711664247 0.630434782608695 0.475484517409163 0.767934281200055 0.630434782608695 0.475484517409163 0.767934281200055 0.630434782608695 0.475484517409163 0.767934281200055 7.27803785874211 3.86195728806017 14.1335556745065 7.17623154224385e-11 48 1762 True False 0 0 0 0 0 0 0 7.27803785874211 3.86195728806017 14.1335556745065 0.00765979926043317 0.0051357154136685 0.0109823600342142 0.99894054593045 0.998304251550396 0.999382711664247 20 Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Ile31Ser pncA_p.Ile31Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 27 23 4 23 4 4386 16818 0.00521660240417328 0.00330966639536383 0.0078172430377722 0.999762216145523 0.999391291831884 0.999935208223951 0.851851851851851 0.662689135975755 0.958112603526232 0.851851851851851 0.662689135975755 0.958112603526232 0.851851851851851 0.662689135975755 0.958112603526232 22.048221614227 7.52623111102046 87.8732941940183 1.38205792031937e-12 45 1830 True False 22.048221614227 7.52623111102046 87.8732941940183 0.00521660240417328 0.00330966639536383 0.0078172430377722 0.999762216145523 0.999391291831884 0.999935208223951 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 25 21 4 21 4 3765 16042 0.00554675118858954 0.00343670743226419 0.00846636420321878 0.999750716689517 0.999361859844744 0.999932074644789 0.84 0.639171545540727 0.95462054762829 0.84 0.639171545540727 0.95462054762829 0.84 0.639171545540727 0.95462054762829 22.3693227091633 7.53971987894923 89.6906256601635 4.28711935920793e-12 41 1762 True False 0 0 0 0 0 0 0 22.3693227091633 7.53971987894923 89.6906256601635 0.00554675118858954 0.00343670743226419 0.00846636420321878 0.999750716689517 0.999361859844744 0.999932074644789 31 Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Ile31Thr pncA_p.Ile31Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 1 2 4408 16820 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999881108072762 0.999570588169705 0.999985601311719 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 1.9078947368421 0.0323314320919459 36.6634061310851 0.502600379724595 526 1830 False False 1.9078947368421 0.0323314320919459 36.6634061310851 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 1 2 3785 16044 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999875358344758 0.999549824781286 0.999984904960856 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 2.11941875825627 0.0359146288488272 40.7195918479678 0.470354459331036 493.5 1762 False False 0 0 0 0 0 0 0 2.11941875825627 0.0359146288488272 40.7195918479678 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999875358344758 0.999549824781286 0.999984904960856 27 Not assoc w R Assoc w RI Literature evidence (PMID 32571824) 2) Assoc w R - Interim No change yes Lit. (PMID 32571824) 1 +Pyrazinamide pncA p.Ile5Ser pncA_p.Ile5Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 27 27 0 27 0 4382 16822 0.00612383760489907 0.0040394118523243 0.00889744417883342 1 0.999780735048249 1 1 0.872297132384567 1 1 0.872297132384567 1 1 0.872297132384567 1 Inf 26.2016658288301 Inf 3.47952393736561e-19 30 1830 True False Inf 26.2016658288301 Inf 0.00612383760489907 0.0040394118523243 0.00889744417883342 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 27 27 0 27 0 3759 16046 0.00713153724247226 0.00470483491393888 0.0103591696773319 1 0.999770132403032 1 1 0.872297132384567 1 1 0.872297132384567 1 1 0.872297132384567 1 Inf 29.1381685713285 Inf 3.54252352552889e-20 24 1762 True False 0 0 0 0 0 0 0 Inf 29.1381685713285 Inf 0.00713153724247226 0.00470483491393888 0.0103591696773319 1 0.999770132403032 1 160 Assoc w RI 1) Assoc w R UP from AwRI to AwR yes 4 +Pyrazinamide pncA p.Ile5Thr pncA_p.Ile5Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 1 2 4408 16820 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999881108072762 0.999570588169705 0.999985601311719 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 1.9078947368421 0.0323314320919459 36.6634061310851 0.502600379724595 526 1830 False False 1.9078947368421 0.0323314320919459 36.6634061310851 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 1 2 3785 16044 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999875358344758 0.999549824781286 0.999984904960856 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 2.11941875825627 0.0359146288488272 40.7195918479678 0.470354459331036 493.5 1762 False False 0 0 0 0 0 0 0 2.11941875825627 0.0359146288488272 40.7195918479678 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999875358344758 0.999549824781286 0.999984904960856 14 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Ile6_Val7del pncA_p.Ile6_Val7del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 2 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Pyrazinamide pncA p.Ile6fs pncA_p.Ile6fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Ile6Leu pncA_p.Ile6Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 19 1 18 2 18 4407 16804 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.998929972654856 0.998309420654136 0.99936571457723 0.1 0.0123485271702948 0.316982714019082 0.0526315789473684 0.00133162880417942 0.260280654195214 0.0526315789473684 0.00133162880417942 0.260280654195214 0.211834707409928 0.00508678334417936 1.34245696129264 0.151758690214811 324 1830 False False 0.423669414819857 0.0476606015331002 1.77072021666596 0.000226860254083484 5.74358785768897e-06 0.0012633291757201 0.998929972654856 0.998309420654136 0.99936571457723 3) Uncertain significance 4) Not assoc w R - Interim WHO 4) Not assoc w R - interim 1 18 0 18 1 18 3785 16028 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.998878225102829 0.998227689237744 0.999335033867569 0.0526315789473684 0.00133162880417942 0.260280654195214 0 0 0.185301968137852 0 0 0.185301968137852 0 0 0.963707479668221 0.034340014320626 221 1762 False False 0 0 0 0 0 0 0 0.235256127990606 0.00564851425373584 1.49102455534335 0 0 0.000974130102511011 0.998878225102829 0.998227689237744 0.999335033867569 128 Not assoc w R Not assoc w RI 4) Not assoc w R - Interim No change yes 1 +Pyrazinamide pncA p.Ile6Ser pncA_p.Ile6Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.097852308370781 Inf 0.207630711257654 334.5 1830 False False Inf 0.716637886286628 Inf 0.000226860254083484 5.74358785768897e-06 0.0012633291757201 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.108701618838585 Inf 0.190862790580404 314.5 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0.000264200792602377 6.68896256519433e-06 0.00147114392376758 1 0.999770132403032 1 8 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Ile6Thr pncA_p.Ile6Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 12 12 0 12 0 4397 16822 0.00272170560217736 0.00140711126319081 0.00474944049676375 1 0.999780735048249 1 1 0.735351530602948 1 1 0.735351530602948 1 1 0.735351530602948 1 Inf 10.6239097645824 Inf 6.35739683533611e-09 61 1830 True False Inf 10.6239097645824 Inf 0.00272170560217736 0.00140711126319081 0.00474944049676375 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 11 11 0 11 0 3775 16046 0.00290544109878499 0.00145125037710396 0.0051926765025673 1 0.999770132403032 1 1 0.715085847081845 1 1 0.715085847081845 1 1 0.715085847081845 1 Inf 10.6608738336509 Inf 1.21295522163799e-08 61 1762 True False 0 0 0 0 0 0 0 Inf 10.6608738336509 Inf 0.00290544109878499 0.00145125037710396 0.0051926765025673 1 0.999770132403032 1 16 Assoc w R Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Ile6Val pncA_p.Ile6Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 9 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Ile90Asn pncA_p.Ile90Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.716637886286628 Inf 0.0431182613129385 265.5 1830 False False Inf 0.716637886286628 Inf 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 2 2 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.796077158748321 Inf 0.0364363919492442 248 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 2) Assoc w R - Interim New AwRI yes 5 +Pyrazinamide pncA p.Ile90Ser pncA_p.Ile90Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 10 7 3 7 3 4402 16819 0.00158766160127012 0.000638553061192671 0.00326843667440656 0.999821662109142 0.999478910338162 0.999963220929399 0.7 0.347547149940002 0.933260488822265 0.7 0.347547149940002 0.933260488822265 0.7 0.347547149940002 0.933260488822265 8.91511434196577 2.03392656490171 53.4604025487181 0.00109454100495658 159 1830 True False 8.91511434196577 2.03392656490171 53.4604025487181 0.00158766160127012 0.000638553061192671 0.00326843667440656 0.999821662109142 0.999478910338162 0.999963220929399 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 10 7 3 7 3 3779 16043 0.00184891706286318 0.000743673531480306 0.00380574231364529 0.999813037517138 0.999453714469566 0.999961442181588 0.7 0.347547149940002 0.933260488822265 0.7 0.347547149940002 0.933260488822265 0.7 0.347547149940002 0.933260488822265 9.90570697715445 2.25978352779509 59.3979304032629 0.000639761373685695 137 1762 True False 0 0 0 0 0 0 0 9.90570697715445 2.25978352779509 59.3979304032629 0.00184891706286318 0.000743673531480306 0.00380574231364529 0.999813037517138 0.999453714469566 0.999961442181588 8 Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Ile90Thr pncA_p.Ile90Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 3 0 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 1.57702975056642 Inf 0.00895106588186537 214 1830 False False Inf 1.57702975056642 Inf 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 NA Assoc w RI 2) Assoc w R - Interim No change yes 1 +Pyrazinamide pncA p.Leu116Arg pncA_p.Leu116Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 7 0 7 0 4402 16822 0.00158766160127012 0.000638553061192671 0.00326843667440656 1 0.999780735048249 1 1 0.590383602774996 1 1 0.590383602774996 1 1 0.590383602774996 1 Inf 5.50478416804174 Inf 1.65938667095456e-05 115.5 1830 True False Inf 5.50478416804174 Inf 0.00158766160127012 0.000638553061192671 0.00326843667440656 1 0.999780735048249 1 1) Assoc w R 2) Assoc w R - Interim WHO 2) Assoc w R - Interim 1 4 4 0 4 0 3782 16046 0.00105652403592181 0.000287939890647285 0.00270289202199999 1 0.999770132403032 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 2.79918348098377 Inf 0.0013264757267559 157.5 1762 True False 0 0 0 0 0 0 0 Inf 2.79918348098377 Inf 0.00105652403592181 0.000287939890647285 0.00270289202199999 1 0.999770132403032 1 7 Assoc w R Assoc w RI Interim based on WHO dataset 2) Assoc w R - Interim No change yes Interim on WHO 1 +Pyrazinamide pncA p.Leu116Pro pncA_p.Leu116Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 3 4 6 4 4403 16818 0.00136085280108868 0.000499567554195151 0.00295963286153356 0.999762216145523 0.999391291831884 0.999935208223951 0.6 0.262378076606945 0.878447741880172 0.428571428571428 0.0989882784425078 0.815948432359917 0.428571428571428 0.0989882784425078 0.815948432359917 2.86475130592777 0.419462496678014 16.9373856159547 0.161240754155993 325 1830 False False 5.72950261185555 1.35791499221539 27.6115879401075 0.000680889695869269 0.000140437841466692 0.00198854668835516 0.999762216145523 0.999391291831884 0.999935208223951 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 5 3 2 6 2 3780 16044 0.00158478605388272 0.000581803608073282 0.0034461969631646 0.999875358344758 0.999549824781286 0.999984904960856 0.75 0.349144205587175 0.968145973750055 0.6 0.146632799634673 0.947255049473683 0.6 0.146632799634673 0.947255049473683 6.36666666666666 0.728971524361021 76.1187713304241 0.0510620251193044 270 1762 False False 0 0 0 0 0 0 0 12.7333333333333 2.27524901217992 129.190351757936 0.000793021411578112 0.000163569947138865 0.0023157791001164 0.999875358344758 0.999549824781286 0.999984904960856 27 Assoc w RI 2) Assoc w R - Interim No change yes 1 +Pyrazinamide pncA p.Leu116Val pncA_p.Leu116Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Leu117fs pncA_p.Leu117fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Leu120Arg pncA_p.Leu120Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 15 15 0 15 0 4394 16822 0.0034021320027217 0.00190535929953375 0.005605100858211 1 0.999780735048249 1 1 0.781980639089466 1 1 0.781980639089466 1 1 0.781980639089466 1 Inf 13.7221712262285 Inf 5.65378144121353e-11 50.5 1830 True False Inf 13.7221712262285 Inf 0.0034021320027217 0.00190535929953375 0.005605100858211 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 13 13 0 13 0 3773 16046 0.0034337031167459 0.00182953006918454 0.00586457926930979 1 0.999770132403032 1 1 0.752947361999529 1 1 0.752947361999529 1 1 0.752947361999529 1 Inf 12.9516379657707 Inf 4.39880194628741e-10 51 1762 True False 0 0 0 0 0 0 0 Inf 12.9516379657707 Inf 0.0034337031167459 0.00182953006918454 0.00586457926930979 1 0.999770132403032 1 20 Assoc w RI 1) Assoc w R UP from AwRI to AwR yes 4 +Pyrazinamide pncA p.Leu120Gln pncA_p.Leu120Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 4 0 4 0 4405 16822 0.000907235200725788 0.000247244623732042 0.00232123869101376 1 0.999780735048249 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 2.51959224712996 Inf 0.00185784794966548 174 1830 True False Inf 2.51959224712996 Inf 0.000907235200725788 0.000247244623732042 0.00232123869101376 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 4 4 0 4 0 3782 16046 0.00105652403592181 0.000287939890647285 0.00270289202199999 1 0.999770132403032 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 2.79918348098377 Inf 0.0013264757267559 157.5 1762 True False 0 0 0 0 0 0 0 Inf 2.79918348098377 Inf 0.00105652403592181 0.000287939890647285 0.00270289202199999 1 0.999770132403032 1 1 Assoc w RI 2) Assoc w R - Interim No change yes 1 +Pyrazinamide pncA p.Leu120Pro pncA_p.Leu120Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 28 28 0 28 0 4381 16822 0.00635064640508051 0.0042239847797466 0.00916546749895474 1 0.999780735048249 1 1 0.876563881499736 1 1 0.876563881499736 1 1 0.876563881499736 1 Inf 27.2331898879653 Inf 7.19075358118098e-20 29 1830 True False Inf 27.2331898879653 Inf 0.00635064640508051 0.0042239847797466 0.00916546749895474 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 19 19 0 19 0 3767 16046 0.00501848917062863 0.00302408120608821 0.00782594556552751 1 0.999770132403032 1 1 0.823533088193034 1 1 0.823533088193034 1 1 0.823533088193034 1 Inf 19.8611544368769 Inf 2.08720983239118e-14 33 1762 True False 0 0 0 0 0 0 0 Inf 19.8611544368769 Inf 0.00501848917062863 0.00302408120608821 0.00782594556552751 1 0.999770132403032 1 18 Assoc w R Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Leu151fs pncA_p.Leu151fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 3 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Leu151Ser pncA_p.Leu151Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 24 18 6 19 6 4390 16816 0.00430936720344749 0.0025964540708268 0.00672146538628393 0.999643324218285 0.999223829869625 0.999869095386533 0.76 0.548711982183313 0.906435560668257 0.75 0.53288719757733 0.902269590525467 0.75 0.53288719757733 0.902269590525467 11.4915717539863 4.36619184287541 35.4024206332522 1.8225453073109e-08 64 1830 True False 12.1299924069855 4.65284143083984 37.0949245603844 0.00408348457350272 0.00242187269709156 0.00644601666777902 0.999643324218285 0.999223829869625 0.999869095386533 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 22 16 6 17 6 3769 16040 0.00449022715266772 0.00261783253916465 0.00717958501762183 0.999626075034276 0.999186301793093 0.999862764161372 0.739130434782608 0.515948029597562 0.897713866084641 0.727272727272727 0.497778798733651 0.892710751629603 0.727272727272727 0.497778798733651 0.892710751629603 11.3487220306005 4.21390421099358 35.4495890975419 6.92195915010753e-08 69 1762 True False 0 0 0 0 0 0 0 12.058017157513 4.53117165862328 37.3482527142844 0.00422721268163804 0.00241808902127498 0.00685567466598668 0.999626075034276 0.999186301793093 0.999862764161372 20 Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Leu151Trp pncA_p.Leu151Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 2 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Leu156fs pncA_p.Leu156fs 1 frameshift (see "Genomic_coordinates" sheet) 1 8 7 1 7 1 4402 16821 0.00158766160127012 0.000638553061192671 0.00326843667440656 0.99994055403638 0.999668833292177 0.99999849495964 0.875 0.473490329124793 0.996840276468748 0.875 0.473490329124793 0.996840276468748 0.875 0.473490329124793 0.996840276468748 26.7485233984552 3.43432279452703 1197.87100642049 0.000108659178644894 138 1830 True False 26.7485233984552 3.43432279452703 1197.87100642049 0.00158766160127012 0.000638553061192671 0.00326843667440656 0.99994055403638 0.999668833292177 0.99999849495964 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 7 6 1 6 1 3780 16045 0.00158478605388272 0.000581803608073282 0.0034461969631646 0.999937679172379 0.999652820032955 0.999998422174497 0.857142857142857 0.421276802956804 0.996389703138099 0.857142857142857 0.421276802956804 0.996389703138099 0.857142857142857 0.421276802956804 0.996389703138099 25.4682539682539 3.08757049174508 1164.0629045087 0.000282550572425536 135.5 1762 True False 0 0 0 0 0 0 0 25.4682539682539 3.08757049174508 1164.0629045087 0.00158478605388272 0.000581803608073282 0.0034461969631646 0.999937679172379 0.999652820032955 0.999998422174497 14 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Leu156Pro pncA_p.Leu156Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 27 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Leu159Arg pncA_p.Leu159Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 10 8 2 8 2 4401 16820 0.00181447040145157 0.000783674794110066 0.0035720830153558 0.999881108072762 0.999570588169705 0.999985601311719 0.8 0.443904537692358 0.974789273673166 0.8 0.443904537692358 0.974789273673166 0.8 0.443904537692358 0.974789273673166 15.2874346739377 3.04876073502229 147.714411457989 0.000103106674846058 134 1830 True False 15.2874346739377 3.04876073502229 147.714411457989 0.00181447040145157 0.000783674794110066 0.0035720830153558 0.999881108072762 0.999570588169705 0.999985601311719 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 8 6 2 6 2 3780 16044 0.00158478605388272 0.000581803608073282 0.0034461969631646 0.999875358344758 0.999549824781286 0.999984904960856 0.75 0.349144205587175 0.968145973750055 0.75 0.349144205587175 0.968145973750055 0.75 0.349144205587175 0.968145973750055 12.7333333333333 2.27524901217992 129.190351757936 0.000946246416919865 138.5 1762 True False 0 0 0 0 0 0 0 12.7333333333333 2.27524901217992 129.190351757936 0.00158478605388272 0.000581803608073282 0.0034461969631646 0.999875358344758 0.999549824781286 0.999984904960856 21 Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Leu159fs pncA_p.Leu159fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 1 4408 16821 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0978242989491397 Inf 0.207677814413565 455 1830 False False 3.81601633393829 0.0486026416232846 298.829108180248 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 1 3785 16045 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.108666134732509 Inf 0.190913216680954 439 1762 False False 0 0 0 0 0 0 0 4.23910171730515 0.0539892730999128 331.863925136224 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 3 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Leu159Pro pncA_p.Leu159Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 4 0 5 0 4404 16822 0.00113404400090723 0.000368320285107068 0.00264447958048867 1 0.999780735048249 1 1 0.478176249895018 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 2.52016409354347 Inf 0.00185651221847041 163.5 1830 True False Inf 3.49836879238979 Inf 0.000907441016333938 0.0002473007258695 0.00232176491492765 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 4 4 0 5 0 3781 16046 0.00132065504490227 0.000428947757354115 0.0030792549559865 1 0.999770132403032 1 1 0.478176249895018 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 2.7999233027091 Inf 0.00132534158702044 145.5 1762 True False 0 0 0 0 0 0 0 Inf 3.88652681138742 Inf 0.00105680317040951 0.000288015983802204 0.00270360553930617 1 0.999770132403032 1 13 2) Assoc w R - Interim UP from Uncertain to AwRI yes 4 +Pyrazinamide pncA p.Leu159Val pncA_p.Leu159Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 3 2 3 2 4406 16820 0.000680426400544341 0.000140342268876931 0.00198719451371054 0.999881108072762 0.999570588169705 0.999985601311719 0.6 0.146632799634673 0.947255049473683 0.6 0.146632799634673 0.947255049473683 0.6 0.146632799634673 0.947255049473683 5.72628234226055 0.655677739135472 68.675028521871 0.0639561690130486 294 1830 False False 5.72628234226055 0.655677739135472 68.675028521871 0.000680426400544341 0.000140342268876931 0.00198719451371054 0.999881108072762 0.999570588169705 0.999985601311719 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 4 3 1 3 1 3783 16045 0.000792393026941363 0.000163440311798119 0.00231394549068866 0.999937679172379 0.999652820032955 0.999998422174497 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 12.7240285487708 1.02115021686679 665.307410149575 0.0238320316469516 213.5 1762 False False 0 0 0 0 0 0 0 12.7240285487708 1.02115021686679 665.307410149575 0.000792393026941363 0.000163440311798119 0.00231394549068866 0.999937679172379 0.999652820032955 0.999998422174497 6 2) Assoc w R - Interim UP from Uncertain to AwRI yes 4 +Pyrazinamide pncA p.Leu172Arg pncA_p.Leu172Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 4 Assoc w RI 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Pyrazinamide pncA p.Leu172fs pncA_p.Leu172fs 1 frameshift (see "Genomic_coordinates" sheet) 1 4 4 0 4 0 4405 16822 0.000907235200725788 0.000247244623732042 0.00232123869101376 1 0.999780735048249 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 2.51959224712996 Inf 0.00185784794966548 174 1830 True False Inf 2.51959224712996 Inf 0.000907235200725788 0.000247244623732042 0.00232123869101376 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Leu172Pro pncA_p.Leu172Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 31 31 0 31 0 4378 16822 0.00703107280562485 0.0047821267574083 0.00996532103680225 1 0.999780735048249 1 1 0.88781125307763 1 1 0.88781125307763 1 1 0.88781125307763 1 Inf 30.3857974596445 Inf 6.33966377407116e-22 25 1830 True False Inf 30.3857974596445 Inf 0.00703107280562485 0.0047821267574083 0.00996532103680225 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 31 31 0 31 0 3755 16046 0.00818806127839408 0.00556997590891501 0.0116023265173252 1 0.999770132403032 1 1 0.88781125307763 1 1 0.88781125307763 1 1 0.88781125307763 1 Inf 33.7901990763547 Inf 4.59135438414503e-23 17 1762 True False 0 0 0 0 0 0 0 Inf 33.7901990763547 Inf 0.00818806127839408 0.00556997590891501 0.0116023265173252 1 0.999770132403032 1 68 Assoc w R Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Leu182Phe pncA_p.Leu182Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 1 4 1 4 4408 16818 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999762216145523 0.999391291831884 0.999935208223951 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 0.95383393829401 0.0193637820130019 9.63941079069668 1 1273 1830 False False 0.95383393829401 0.0193637820130019 9.63941079069668 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999762216145523 0.999391291831884 0.999935208223951 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Leu182Ser pncA_p.Leu182Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 18 14 4 15 4 4394 16818 0.0034021320027217 0.00190535929953375 0.005605100858211 0.999762216145523 0.999391291831884 0.999935208223951 0.789473684210526 0.544346918108494 0.93947546229071 0.777777777777777 0.52362723426352 0.935907952282333 0.777777777777777 0.52362723426352 0.935907952282333 13.3962221210741 4.20424170578926 55.9337399199371 3.53337617996859e-07 81 1830 True False 14.3530951297223 4.56931651266777 59.4402166839907 0.00317604355716878 0.00173742681384763 0.00532312526061524 0.999762216145523 0.999391291831884 0.999935208223951 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 18 14 4 15 4 3771 16042 0.00396196513470681 0.002219125650155 0.0065262525797864 0.999750716689517 0.999361859844744 0.999932074644789 0.789473684210526 0.544346918108494 0.93947546229071 0.777777777777777 0.52362723426352 0.935907952282333 0.777777777777777 0.52362723426352 0.935907952282333 14.8891540705383 4.67222023717941 62.2578516925293 1.1700518036636e-07 70 1762 True False 0 0 0 0 0 0 0 15.9526650755767 5.07716011426082 66.0928018355374 0.00369881109643328 0.00202360459687417 0.00619819662089327 0.999750716689517 0.999361859844744 0.999932074644789 57 Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Leu182Trp pncA_p.Leu182Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 6 0 6 0 4403 16822 0.00136085280108868 0.000499567554195151 0.00295963286153356 1 0.999780735048249 1 1 0.540741873560099 1 1 0.540741873560099 1 1 0.540741873560099 1 Inf 4.49627002862219 Inf 7.99920101998881e-05 128.5 1830 True False Inf 4.49627002862219 Inf 0.00136085280108868 0.000499567554195151 0.00295963286153356 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 6 6 0 6 0 3780 16046 0.00158478605388272 0.000581803608073282 0.0034461969631646 1 0.999770132403032 1 1 0.540741873560099 1 1 0.540741873560099 1 1 0.540741873560099 1 Inf 4.99466385094306 Inf 4.82493639119799e-05 113.5 1762 True False 0 0 0 0 0 0 0 Inf 4.99466385094306 Inf 0.00158478605388272 0.000581803608073282 0.0034461969631646 1 0.999770132403032 1 10 Assoc w RI 1) Assoc w R UP from AwRI to AwR yes 4 +Pyrazinamide pncA p.Leu19_Val21del pncA_p.Leu19_Val21del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Pyrazinamide pncA p.Leu19Arg pncA_p.Leu19Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA p.Leu19Pro pncA_p.Leu19Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 11 10 1 10 1 4399 16821 0.00226808800181447 0.00108815543692413 0.00416712622349087 0.99994055403638 0.999668833292177 0.99999849495964 0.909090909090909 0.587220083011617 0.997701027786185 0.909090909090909 0.587220083011617 0.997701027786185 0.909090909090909 0.587220083011617 0.997701027786185 38.2382359627188 5.43632314626283 1645.1103984026 1.32095946640665e-06 97.5 1830 True False 38.2382359627188 5.43632314626283 1645.1103984026 0.00226808800181447 0.00108815543692413 0.00416712622349087 0.99994055403638 0.999668833292177 0.99999849495964 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 10 9 1 9 1 3777 16045 0.00237717908082408 0.00108755584228183 0.00450780893694816 0.999937679172379 0.999652820032955 0.999998422174497 0.9 0.554983882971804 0.997471421455538 0.9 0.554983882971804 0.997471421455538 0.9 0.554983882971804 0.997471421455538 38.232724384432 5.29419450309442 1660.92197563144 2.76875337693198e-06 96 1762 True False 0 0 0 0 0 0 0 38.232724384432 5.29419450309442 1660.92197563144 0.00237717908082408 0.00108755584228183 0.00450780893694816 0.999937679172379 0.999652820032955 0.999998422174497 22 Assoc w RI 1) Assoc w R UP from AwRI to AwR yes 4 +Pyrazinamide pncA p.Leu27Gln pncA_p.Leu27Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Leu27Pro pncA_p.Leu27Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 41 41 0 44 0 4365 16822 0.00997958720798367 0.00726028427872568 0.0133742087090865 1 0.999780735048249 1 1 0.919580060236424 1 1 0.913956163705971 1 1 0.913956163705971 1 Inf 40.8943859953021 Inf 8.67487838257893e-29 15 1830 True False Inf 44.0366209956907 Inf 0.00930549251021334 0.00668582379725209 0.0126029818270543 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 40 40 0 43 0 3743 16046 0.0113576333861595 0.00823143317696189 0.0152684689795526 1 0.999770132403032 1 1 0.917788878845861 1 1 0.911902697121197 1 1 0.911902697121197 1 Inf 44.3384204745989 Inf 1.40817779928842e-29 13 1762 True False 0 0 0 0 0 0 0 Inf 47.7927795695954 Inf 0.0105736188210415 0.00756439342068475 0.0143706990506896 1 0.999770132403032 1 342 Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Leu35Arg pncA_p.Leu35Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 35 3 32 4 32 4405 16790 0.000907235200725788 0.000247244623732042 0.00232123869101376 0.998097729164189 0.997315612940588 0.99869849551898 0.111111111111111 0.0311161399450152 0.260610920510829 0.0857142857142857 0.0180376398142174 0.230575018658877 0.0857142857142857 0.0180376398142174 0.230575018658877 0.357335414301929 0.0699806133568713 1.1430838565091 0.0932412400008629 301 1830 False False 0.476447219069239 0.122347523096329 1.34454909813693 0.000680580762250453 0.000140374111950171 0.0019876450342228 0.998097729164189 0.997315612940588 0.99869849551898 3) Uncertain significance 4) Not assoc w R - Interim WHO 4) Not assoc w R - interim 1 33 3 30 4 30 3782 16016 0.00105652403592181 0.000287939890647285 0.00270289202199999 0.998130375171382 0.997332061268946 0.998738227457322 0.117647058823529 0.0330016803364695 0.274503487142355 0.0909090909090909 0.0191549429874049 0.243316350759155 0.0909090909090909 0.0191549429874049 0.243316350759155 0.423479640401903 0.0826580071384475 1.36287637097486 0.183961703984143 308 1762 False False 0 0 0 0 0 0 0 0.564639520535871 0.144430727683896 1.6037316546632 0.000792602377807133 0.000163483500741026 0.00231455637111671 0.998130375171382 0.997332061268946 0.998738227457322 20 Not assoc w R Not assoc w RI 4) Not assoc w R - Interim No change yes 1 +Pyrazinamide pncA p.Leu35Pro pncA_p.Leu35Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 5 3 5 3 4404 16819 0.00113404400090723 0.000368320285107068 0.00264447958048867 0.999821662109142 0.999478910338162 0.999963220929399 0.625 0.244863216366551 0.914766585862746 0.625 0.244863216366551 0.914766585862746 0.625 0.244863216366551 0.914766585862746 6.36504692703602 1.23768373585682 41.0231847707768 0.0122620652361904 226 1830 False False 6.36504692703602 1.23768373585682 41.0231847707768 0.00113404400090723 0.000368320285107068 0.00264447958048867 0.999821662109142 0.999478910338162 0.999963220929399 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 8 5 3 5 3 3781 16043 0.00132065504490227 0.000428947757354115 0.0030792549559865 0.999813037517138 0.999453714469566 0.999961442181588 0.625 0.244863216366551 0.914766585862746 0.625 0.244863216366551 0.914766585862746 0.625 0.244863216366551 0.914766585862746 7.07176232037379 1.37501841621148 45.5380701298121 0.00845631333330319 203.5 1762 False False 0 0 0 0 0 0 0 7.07176232037379 1.37501841621148 45.5380701298121 0.00132065504490227 0.000428947757354115 0.0030792549559865 0.999813037517138 0.999453714469566 0.999961442181588 6 2) Assoc w R - Interim UP from Uncertain to AwRI yes 4 +Pyrazinamide pncA p.Leu4fs pncA_p.Leu4fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Leu4Phe pncA_p.Leu4Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1333 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1281 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA p.Leu4Ser pncA_p.Leu4Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 43 40 3 42 3 4367 16819 0.00952596960762077 0.00687386273288133 0.012854748172689 0.999821662109142 0.999478910338162 0.999963220929399 0.933333333333333 0.817315543421773 0.986034902955629 0.930232558139534 0.809392768114207 0.985374503004867 0.930232558139534 0.809392768114207 0.985374503004867 51.3518052057094 16.335209571812 258.417746848044 2.66882471760556e-24 20 1830 True False 53.9193954659949 17.2184878853946 270.462613699204 0.0090764692534604 0.00649205530542652 0.0123392642528843 0.999821662109142 0.999478910338162 0.999963220929399 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 34 32 2 34 2 3752 16044 0.00898045430533544 0.00622701536814537 0.0125268703397902 0.999875358344758 0.999549824781286 0.999984904960856 0.944444444444444 0.813363293542446 0.993199699345977 0.941176470588235 0.803226790664424 0.99279508256095 0.941176470588235 0.803226790664424 0.99279508256095 68.4179104477611 17.4446519236876 588.483500133008 3.2099241825002e-21 19.5 1762 True False 0 0 0 0 0 0 0 72.6940298507462 18.6184986633149 623.739204211696 0.00845665961945031 0.00579133438122877 0.0119174801683906 0.999875358344758 0.999549824781286 0.999984904960856 74 Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Leu4Trp pncA_p.Leu4Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 16 15 1 15 1 4394 16821 0.0034021320027217 0.00190535929953375 0.005605100858211 0.99994055403638 0.999668833292177 0.99999849495964 0.9375 0.697679261565468 0.998418888277234 0.9375 0.697679261565468 0.998418888277234 0.9375 0.697679261565468 0.998418888277234 57.4226217569412 8.83019838608321 2386.49283173096 7.28963658615287e-10 56 1830 True False 57.4226217569412 8.83019838608321 2386.49283173096 0.0034021320027217 0.00190535929953375 0.005605100858211 0.99994055403638 0.999668833292177 0.99999849495964 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 13 12 1 12 1 3774 16045 0.00316957210776545 0.00163880353722015 0.00553005230777549 0.999937679172379 0.999652820032955 0.999998422174497 0.923076923076923 0.639702564732122 0.998054371502653 0.923076923076923 0.639702564732122 0.998054371502653 0.923076923076923 0.639702564732122 0.998054371502653 51.0174880763116 7.542725603712 2155.62757690633 2.47531098817422e-08 64.5 1762 True False 0 0 0 0 0 0 0 51.0174880763116 7.542725603712 2155.62757690633 0.00316957210776545 0.00163880353722015 0.00553005230777549 0.999937679172379 0.999652820032955 0.999998422174497 32 Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Leu85Arg pncA_p.Leu85Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 9 0 9 0 4400 16822 0.00204127920163302 0.000933814369660709 0.00387143149170671 1 0.999780735048249 1 1 0.663732883120057 1 1 0.663732883120057 1 1 0.663732883120057 1 Inf 7.54177743415507 Inf 7.13698843528946e-07 90.5 1830 True False Inf 7.54177743415507 Inf 0.00204127920163302 0.000933814369660709 0.00387143149170671 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 8 8 0 8 0 3778 16046 0.00211304807184363 0.00091269178353604 0.00415927925423806 1 0.999770132403032 1 1 0.63058335244718 1 1 0.63058335244718 1 1 0.63058335244718 1 Inf 7.24385478693174 Inf 1.75352509766709e-06 91 1762 True False 0 0 0 0 0 0 0 Inf 7.24385478693174 Inf 0.00211304807184363 0.00091269178353604 0.00415927925423806 1 0.999770132403032 1 37 Assoc w R Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Leu85fs pncA_p.Leu85fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Leu85Pro pncA_p.Leu85Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 10 10 0 10 0 4399 16822 0.00226808800181447 0.00108815543692413 0.00416712622349087 1 0.999780735048249 1 1 0.691502892181239 1 1 0.691502892181239 1 1 0.691502892181239 1 Inf 8.56754994230848 Inf 1.47972618581065e-07 77 1830 True False Inf 8.56754994230848 Inf 0.00226808800181447 0.00108815543692413 0.00416712622349087 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 7 7 0 7 0 3779 16046 0.00184891706286318 0.000743673531480306 0.00380574231364529 1 0.999770132403032 1 1 0.590383602774996 1 1 0.590383602774996 1 1 0.590383602774996 1 Inf 6.11594331475081 Inf 9.19916249305378e-06 102.5 1762 True False 0 0 0 0 0 0 0 Inf 6.11594331475081 Inf 0.00184891706286318 0.000743673531480306 0.00380574231364529 1 0.999770132403032 1 16 Assoc w R Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Lys48_Val155delinsMet pncA_p.Lys48_Val155delinsMet 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Pyrazinamide pncA p.Lys48Asn pncA_p.Lys48Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.23555131695149 1 1273 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 3 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Lys48fs pncA_p.Lys48fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.716637886286628 Inf 0.0431182613129385 265.5 1830 False False Inf 0.716637886286628 Inf 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 2 2 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.796077158748321 Inf 0.0364363919492442 248 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 4 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Lys48Glu pncA_p.Lys48Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 2 1 2 1 4407 16821 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.99994055403638 0.999668833292177 0.99999849495964 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 7.63376446562287 0.397281353658273 449.052313013199 0.111452652175084 308.5 1830 False False 7.63376446562287 0.397281353658273 449.052313013199 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.99994055403638 0.999668833292177 0.99999849495964 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 3 2 1 2 1 3784 16045 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999937679172379 0.999652820032955 0.999998422174497 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 8.48044397463002 0.441282441622781 498.676520130596 0.0954034464341229 286.5 1762 False False 0 0 0 0 0 0 0 8.48044397463002 0.441282441622781 498.676520130596 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999937679172379 0.999652820032955 0.999998422174497 8 Assoc w RI 2) Assoc w R - Interim No change yes 1 +Pyrazinamide pncA p.Lys48Thr pncA_p.Lys48Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 46 20 26 20 26 4389 16796 0.00453617600362894 0.00277294929564062 0.00699710319549207 0.998454404945904 0.997736159451709 0.998990125307939 0.434782608695652 0.289343281216286 0.588928635226589 0.434782608695652 0.289343281216286 0.588928635226589 0.434782608695652 0.289343281216286 0.588928635226589 2.94372294372294 1.55640060459907 5.48808589137302 0.000710293138823791 158 1830 True False 2.94372294372294 1.55640060459907 5.48808589137302 0.00453617600362894 0.00277294929564062 0.00699710319549207 0.998454404945904 0.997736159451709 0.998990125307939 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance 1 15 7 8 7 8 3779 16038 0.00184891706286318 0.000743673531480306 0.00380574231364529 0.999501433379035 0.999017862631239 0.999784730530787 0.466666666666666 0.212666729519307 0.734138652722603 0.466666666666666 0.212666729519307 0.734138652722603 0.466666666666666 0.212666729519307 0.734138652722603 3.71348240275205 1.14547199808182 11.7279201580222 0.0140113637990407 208 1762 False False 0 0 0 0 0 0 0 3.71348240275205 1.14547199808182 11.7279201580222 0.00184891706286318 0.000743673531480306 0.00380574231364529 0.999501433379035 0.999017862631239 0.999784730530787 52 Assoc w R Assoc w RI Evidence from ALL dataset only 2) Assoc w R - Interim No change yes ALL only 1 +Pyrazinamide pncA p.Lys96Arg pncA_p.Lys96Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 12 10 2 10 2 4399 16820 0.00226808800181447 0.00108815543692413 0.00416712622349087 0.999881108072762 0.999570588169705 0.999985601311719 0.833333333333333 0.515862251314033 0.979137474539907 0.833333333333333 0.515862251314033 0.979137474539907 0.833333333333333 0.515862251314033 0.979137474539907 19.1179813593998 4.0712565281776 179.195437235645 6.43497759647303e-06 111 1830 True False 19.1179813593998 4.0712565281776 179.195437235645 0.00226808800181447 0.00108815543692413 0.00416712622349087 0.999881108072762 0.999570588169705 0.999985601311719 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 12 10 2 10 2 3776 16044 0.00264131008980454 0.00126731492930415 0.00485208155788738 0.999875358344758 0.999549824781286 0.999984904960856 0.833333333333333 0.515862251314033 0.979137474539907 0.833333333333333 0.515862251314033 0.979137474539907 0.833333333333333 0.515862251314033 0.979137474539907 21.2447033898305 4.5239459506141 198.956192990592 2.87397663141202e-06 98 1762 True False 0 0 0 0 0 0 0 21.2447033898305 4.5239459506141 198.956192990592 0.00264131008980454 0.00126731492930415 0.00485208155788738 0.999875358344758 0.999549824781286 0.999984904960856 29 Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Lys96Asn pncA_p.Lys96Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 4 0 4 0 4405 16822 0.000907235200725788 0.000247244623732042 0.00232123869101376 1 0.999780735048249 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 2.51959224712996 Inf 0.00185784794966548 174 1830 True False Inf 2.51959224712996 Inf 0.000907235200725788 0.000247244623732042 0.00232123869101376 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 4 4 0 4 0 3782 16046 0.00105652403592181 0.000287939890647285 0.00270289202199999 1 0.999770132403032 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 2.79918348098377 Inf 0.0013264757267559 157.5 1762 True False 0 0 0 0 0 0 0 Inf 2.79918348098377 Inf 0.00105652403592181 0.000287939890647285 0.00270289202199999 1 0.999770132403032 1 19 2) Assoc w R - Interim UP from Uncertain to AwRI yes 4 +Pyrazinamide pncA p.Lys96fs pncA_p.Lys96fs 1 frameshift (see "Genomic_coordinates" sheet) 1 6 5 1 7 1 4402 16821 0.00158766160127012 0.000638553061192671 0.00326843667440656 0.99994055403638 0.999668833292177 0.99999849495964 0.875 0.473490329124793 0.996840276468748 0.833333333333333 0.358765421002325 0.99578925548551 0.833333333333333 0.358765421002325 0.99578925548551 19.1060881417537 2.13677451398511 899.227596050748 0.00190997506157584 185 1830 True False 26.7485233984552 3.43432279452703 1197.87100642049 0.00113455865668255 0.000368487482593687 0.00264567879916455 0.99994055403638 0.999668833292177 0.99999849495964 1) Assoc w R 2) Assoc w R - Interim WHO 2) Assoc w R - Interim 1 5 4 1 5 1 3781 16045 0.00132065504490227 0.000428947757354115 0.0030792549559865 0.999937679172379 0.999652820032955 0.999998422174497 0.833333333333333 0.358765421002325 0.99578925548551 0.8 0.28358206388191 0.994949236620532 0.8 0.28358206388191 0.994949236620532 16.9743454112668 1.67878435353491 831.972674111947 0.00561573975221539 173.5 1762 False False 0 0 0 0 0 0 0 21.2179317640835 2.3726027647035 998.008782436883 0.00105680317040951 0.000288015983802204 0.00270360553930617 0.999937679172379 0.999652820032955 0.999998422174497 3 Interim based on WHO dataset 2) Assoc w R - Interim No change no Interim on WHO 1 +Pyrazinamide pncA p.Lys96Gln pncA_p.Lys96Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 5 1 5 1 4404 16821 0.00113404400090723 0.000368320285107068 0.00264447958048867 0.99994055403638 0.999668833292177 0.99999849495964 0.833333333333333 0.358765421002325 0.99578925548551 0.833333333333333 0.358765421002325 0.99578925548551 0.833333333333333 0.358765421002325 0.99578925548551 19.0974114441416 2.13580486483461 898.821488982459 0.0019132693883777 189.5 1830 True False 19.0974114441416 2.13580486483461 898.821488982459 0.00113404400090723 0.000368320285107068 0.00264447958048867 0.99994055403638 0.999668833292177 0.99999849495964 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 6 5 1 5 1 3781 16045 0.00132065504490227 0.000428947757354115 0.0030792549559865 0.999937679172379 0.999652820032955 0.999998422174497 0.833333333333333 0.358765421002325 0.99578925548551 0.833333333333333 0.358765421002325 0.99578925548551 0.833333333333333 0.358765421002325 0.99578925548551 21.2179317640835 2.3726027647035 998.008782436883 0.00127682798332212 142 1762 True False 0 0 0 0 0 0 0 21.2179317640835 2.3726027647035 998.008782436883 0.00132065504490227 0.000428947757354115 0.0030792549559865 0.999937679172379 0.999652820032955 0.999998422174497 6 Assoc w RI 1) Assoc w R UP from AwRI to AwR yes 4 +Pyrazinamide pncA p.Lys96Glu pncA_p.Lys96Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 9 0 10 0 4399 16822 0.00226808800181447 0.00108815543692413 0.00416712622349087 1 0.999780735048249 1 1 0.691502892181239 1 1 0.663732883120057 1 1 0.663732883120057 1 Inf 7.54348954111033 Inf 7.12544038352144e-07 85 1830 True False Inf 8.56754994230848 Inf 0.00204174228675136 0.000934026308485198 0.00387230895969948 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 8 8 0 9 0 3777 16046 0.00237717908082408 0.00108755584228183 0.00450780893694816 1 0.999770132403032 1 1 0.663732883120057 1 1 0.63058335244718 1 1 0.63058335244718 1 Inf 7.24578116808799 Inf 1.75052595681586e-06 87 1762 True False 0 0 0 0 0 0 0 Inf 8.37964612204265 Inf 0.00211360634081902 0.000912933030529794 0.00416037701148039 1 0.999770132403032 1 15 Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Lys96Met pncA_p.Lys96Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA p.Lys96Thr pncA_p.Lys96Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 20 19 1 19 1 4390 16821 0.00430936720344749 0.0025964540708268 0.00672146538628393 0.99994055403638 0.999668833292177 0.99999849495964 0.95 0.751267237227972 0.99873491050205 0.95 0.751267237227972 0.99873491050205 0.95 0.751267237227972 0.99873491050205 72.8015945330296 11.56429352145 2975.55031761603 1.66959462192629e-12 46 1830 True False 72.8015945330296 11.56429352145 2975.55031761603 0.00430936720344749 0.0025964540708268 0.00672146538628393 0.99994055403638 0.999668833292177 0.99999849495964 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 19 19 0 19 0 3767 16046 0.00501848917062863 0.00302408120608821 0.00782594556552751 1 0.999770132403032 1 1 0.823533088193034 1 1 0.823533088193034 1 1 0.823533088193034 1 Inf 19.8611544368769 Inf 2.08720983239118e-14 33 1762 True False 0 0 0 0 0 0 0 Inf 19.8611544368769 Inf 0.00501848917062863 0.00302408120608821 0.00782594556552751 1 0.999770132403032 1 80 Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Met1? pncA_p.Met1? 1 start_lost (see "Genomic_coordinates" sheet) 1 9 9 0 9 0 4400 16822 0.00204127920163302 0.000933814369660709 0.00387143149170671 1 0.999780735048249 1 1 0.663732883120057 1 1 0.663732883120057 1 1 0.663732883120057 1 Inf 7.54177743415507 Inf 7.13698843528946e-07 90.5 1830 True False Inf 7.54177743415507 Inf 0.00204127920163302 0.000933814369660709 0.00387143149170671 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 9 9 0 9 0 3777 16046 0.00237717908082408 0.00108755584228183 0.00450780893694816 1 0.999770132403032 1 1 0.663732883120057 1 1 0.663732883120057 1 1 0.663732883120057 1 Inf 8.37964612204265 Inf 3.34181689819727e-07 76.5 1762 True False 0 0 0 0 0 0 0 Inf 8.37964612204265 Inf 0.00237717908082408 0.00108755584228183 0.00450780893694816 1 0.999770132403032 1 34 1) Assoc w R UP from AwRI to AwR yes 4 +Pyrazinamide pncA p.Met175Arg pncA_p.Met175Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 10 10 0 10 0 4399 16822 0.00226808800181447 0.00108815543692413 0.00416712622349087 1 0.999780735048249 1 1 0.691502892181239 1 1 0.691502892181239 1 1 0.691502892181239 1 Inf 8.56754994230848 Inf 1.47972618581065e-07 77 1830 True False Inf 8.56754994230848 Inf 0.00226808800181447 0.00108815543692413 0.00416712622349087 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 9 9 0 9 0 3777 16046 0.00237717908082408 0.00108755584228183 0.00450780893694816 1 0.999770132403032 1 1 0.663732883120057 1 1 0.663732883120057 1 1 0.663732883120057 1 Inf 8.37964612204265 Inf 3.34181689819727e-07 76.5 1762 True False 0 0 0 0 0 0 0 Inf 8.37964612204265 Inf 0.00237717908082408 0.00108755584228183 0.00450780893694816 1 0.999770132403032 1 5 1) Assoc w R UP from Uncertain to AwR yes 4 +Pyrazinamide pncA p.Met175fs pncA_p.Met175fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.716637886286628 Inf 0.0431182613129385 265.5 1830 False False Inf 0.716637886286628 Inf 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 2 2 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.796077158748321 Inf 0.0364363919492442 248 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 3 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Met175Ile pncA_p.Met175Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 4 4 4 4 4405 16818 0.000907235200725788 0.000247244623732042 0.00232123869101376 0.999762216145523 0.999391291831884 0.999935208223951 0.5 0.157012770487058 0.842987229512941 0.5 0.157012770487058 0.842987229512941 0.5 0.157012770487058 0.842987229512941 3.81793416572077 0.710765129584011 20.502441796637 0.0635519936974356 291 1830 False False 3.81793416572077 0.710765129584011 20.502441796637 0.000907235200725788 0.000247244623732042 0.00232123869101376 0.999762216145523 0.999391291831884 0.999935208223951 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 6 3 3 3 3 3783 16043 0.000792393026941363 0.000163440311798119 0.00231394549068866 0.999813037517138 0.999453714469566 0.999961442181588 0.5 0.118117248757025 0.881882751242974 0.5 0.118117248757025 0.881882751242974 0.5 0.118117248757025 0.881882751242974 4.24081416864922 0.567733907706636 31.6728249153222 0.0879918416102538 278 1762 False False 0 0 0 0 0 0 0 4.24081416864922 0.567733907706636 31.6728249153222 0.000792393026941363 0.000163440311798119 0.00231394549068866 0.999813037517138 0.999453714469566 0.999961442181588 20 2) Assoc w R - Interim UP from Uncertain to AwRI yes 4 +Pyrazinamide pncA p.Met175Thr pncA_p.Met175Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 5 0 5 0 4404 16822 0.00113404400090723 0.000368320285107068 0.00264447958048867 1 0.999780735048249 1 1 0.478176249895018 1 1 0.478176249895018 1 1 0.478176249895018 1 Inf 3.49836879238979 Inf 0.000385538239896191 148 1830 True False Inf 3.49836879238979 Inf 0.00113404400090723 0.000368320285107068 0.00264447958048867 1 0.999780735048249 1 1) Assoc w R 2) Assoc w R - Interim WHO 2) Assoc w R - Interim 1 4 4 0 4 0 3782 16046 0.00105652403592181 0.000287939890647285 0.00270289202199999 1 0.999770132403032 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 2.79918348098377 Inf 0.0013264757267559 157.5 1762 True False 0 0 0 0 0 0 0 Inf 2.79918348098377 Inf 0.00105652403592181 0.000287939890647285 0.00270289202199999 1 0.999770132403032 1 7 Assoc w RI Interim based on WHO dataset 2) Assoc w R - Interim No change yes Interim on WHO 1 +Pyrazinamide pncA p.Met175Val pncA_p.Met175Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 14 11 3 12 3 4397 16819 0.00272170560217736 0.00140711126319081 0.00474944049676375 0.999821662109142 0.999478910338162 0.999963220929399 0.8 0.519108866193147 0.956687994894163 0.785714285714285 0.492024322951528 0.953420712110132 0.785714285714285 0.492024322951528 0.953420712110132 14.0253961034038 3.70219671190012 78.3029055532938 5.92975526561488e-06 110 1830 True False 15.3004321128041 4.12595398115344 84.4683017049035 0.00249546279491833 0.00124636378089373 0.00446067538663459 0.999821662109142 0.999478910338162 0.999963220929399 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 13 10 3 11 3 3775 16043 0.00290544109878499 0.00145125037710396 0.0051926765025673 0.999813037517138 0.999453714469566 0.999961442181588 0.785714285714285 0.492024322951528 0.953420712110132 0.769230769230769 0.461868460765959 0.949618926508848 0.769230769230769 0.461868460765959 0.949618926508848 14.166004415011 3.64441417892026 80.1082134976094 1.02839494104253e-05 105 1762 True False 0 0 0 0 0 0 0 15.5826048565121 4.1126349676426 86.9483339746555 0.00264200792602377 0.00126764994117653 0.00485336205963055 0.999813037517138 0.999453714469566 0.999961442181588 35 Assoc w R Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Phe106fs pncA_p.Phe106fs 1 frameshift (see "Genomic_coordinates" sheet) 1 17 15 2 15 2 4394 16820 0.0034021320027217 0.00190535929953375 0.005605100858211 0.999881108072762 0.999570588169705 0.999985601311719 0.88235294117647 0.635590837898749 0.985420683159697 0.88235294117647 0.635590837898749 0.985420683159697 0.88235294117647 0.635590837898749 0.985420683159697 28.7096040054619 6.67066313365219 257.129715831371 4.99420056659219e-09 59 1830 True False 28.7096040054619 6.67066313365219 257.129715831371 0.0034021320027217 0.00190535929953375 0.005605100858211 0.999881108072762 0.999570588169705 0.999985601311719 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 16 14 2 14 2 3772 16044 0.00369783412572636 0.00202306972195899 0.00619656153938766 0.999875358344758 0.999549824781286 0.999984904960856 0.875 0.616523763150736 0.984486396184586 0.875 0.616523763150736 0.984486396184586 0.875 0.616523763150736 0.984486396184586 29.7741251325556 6.83154825799344 268.077915029338 6.79715808072763e-09 59 1762 True False 0 0 0 0 0 0 0 29.7741251325556 6.83154825799344 268.077915029338 0.00369783412572636 0.00202306972195899 0.00619656153938766 0.999875358344758 0.999549824781286 0.999984904960856 18 1) Assoc w R UP from AwRI to AwR yes 4 +Pyrazinamide pncA p.Phe106Ile pncA_p.Phe106Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 1 2 4408 16820 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999881108072762 0.999570588169705 0.999985601311719 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 1.9078947368421 0.0323314320919459 36.6634061310851 0.502600379724595 526 1830 False False 1.9078947368421 0.0323314320919459 36.6634061310851 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 1 2 3785 16044 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999875358344758 0.999549824781286 0.999984904960856 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 2.11941875825627 0.0359146288488272 40.7195918479678 0.470354459331036 493.5 1762 False False 0 0 0 0 0 0 0 2.11941875825627 0.0359146288488272 40.7195918479678 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Phe106Leu pncA_p.Phe106Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.716637886286628 Inf 0.0431182613129385 265.5 1830 False False Inf 0.716637886286628 Inf 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 2 2 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.796077158748321 Inf 0.0364363919492442 248 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 2) Assoc w R - Interim New AwRI yes 5 +Pyrazinamide pncA p.Phe106Ser pncA_p.Phe106Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 3 0 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 1.57702975056642 Inf 0.00895106588186537 214 1830 False False Inf 1.57702975056642 Inf 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 3 3 0 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 1.75196919627044 Inf 0.00695286470680484 189.5 1762 False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 NA Assoc w RI 2) Assoc w R - Interim No change yes 1 +Pyrazinamide pncA p.Phe13fs pncA_p.Phe13fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Phe13Ile pncA_p.Phe13Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 6 0 6 0 4403 16822 0.00136085280108868 0.000499567554195151 0.00295963286153356 1 0.999780735048249 1 1 0.540741873560099 1 1 0.540741873560099 1 1 0.540741873560099 1 Inf 4.49627002862219 Inf 7.99920101998881e-05 128.5 1830 True False Inf 4.49627002862219 Inf 0.00136085280108868 0.000499567554195151 0.00295963286153356 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 6 6 0 6 0 3780 16046 0.00158478605388272 0.000581803608073282 0.0034461969631646 1 0.999770132403032 1 1 0.540741873560099 1 1 0.540741873560099 1 1 0.540741873560099 1 Inf 4.99466385094306 Inf 4.82493639119799e-05 113.5 1762 True False 0 0 0 0 0 0 0 Inf 4.99466385094306 Inf 0.00158478605388272 0.000581803608073282 0.0034461969631646 1 0.999770132403032 1 2 Assoc w RI 1) Assoc w R UP from AwRI to AwR yes 4 +Pyrazinamide pncA p.Phe13Leu pncA_p.Phe13Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 3 1 5 1 4404 16821 0.00113404400090723 0.000368320285107068 0.00264447958048867 0.99994055403638 0.999668833292177 0.99999849495964 0.833333333333333 0.358765421002325 0.99578925548551 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 11.458446866485 0.919642220428243 599.397889928372 0.0302001261028202 228 1830 False False 19.0974114441416 2.13580486483461 898.821488982459 0.00068073519400953 0.00014040596947681 0.001988095759058 0.99994055403638 0.999668833292177 0.99999849495964 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 2 2 0 4 0 3782 16046 0.00105652403592181 0.000287939890647285 0.00270289202199999 1 0.999770132403032 1 1 0.397635364383525 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.796497519692636 Inf 0.0364052436532046 222 1762 False False 0 0 0 0 0 0 0 Inf 2.79918348098377 Inf 0.000528541226215644 6.40152050240878e-05 0.00190795499768937 1 0.999770132403032 1 3 Assoc w RI 2) Assoc w R - Interim No change yes 1 +Pyrazinamide pncA p.Phe13Ser pncA_p.Phe13Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 5 1 5 1 4404 16821 0.00113404400090723 0.000368320285107068 0.00264447958048867 0.99994055403638 0.999668833292177 0.99999849495964 0.833333333333333 0.358765421002325 0.99578925548551 0.833333333333333 0.358765421002325 0.99578925548551 0.833333333333333 0.358765421002325 0.99578925548551 19.0974114441416 2.13580486483461 898.821488982459 0.0019132693883777 189.5 1830 True False 19.0974114441416 2.13580486483461 898.821488982459 0.00113404400090723 0.000368320285107068 0.00264447958048867 0.99994055403638 0.999668833292177 0.99999849495964 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 6 5 1 5 1 3781 16045 0.00132065504490227 0.000428947757354115 0.0030792549559865 0.999937679172379 0.999652820032955 0.999998422174497 0.833333333333333 0.358765421002325 0.99578925548551 0.833333333333333 0.358765421002325 0.99578925548551 0.833333333333333 0.358765421002325 0.99578925548551 21.2179317640835 2.3726027647035 998.008782436883 0.00127682798332212 142 1762 True False 0 0 0 0 0 0 0 21.2179317640835 2.3726027647035 998.008782436883 0.00132065504490227 0.000428947757354115 0.0030792549559865 0.999937679172379 0.999652820032955 0.999998422174497 17 1) Assoc w R UP from Uncertain to AwR yes 4 +Pyrazinamide pncA p.Phe58Cys pncA_p.Phe58Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.716637886286628 Inf 0.0431182613129385 265.5 1830 False False Inf 0.716637886286628 Inf 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 6 2) Assoc w R - Interim UP from Uncertain to AwRI yes 4 +Pyrazinamide pncA p.Phe58Leu pncA_p.Phe58Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 17 13 4 13 4 4396 16818 0.00294851440235881 0.00157086488136083 0.0050367716434693 0.999762216145523 0.999391291831884 0.999935208223951 0.764705882352941 0.501006726795419 0.931892259562643 0.764705882352941 0.501006726795419 0.931892259562643 0.764705882352941 0.501006726795419 0.931892259562643 12.4336897179253 3.83844487016044 52.389960408037 1.3361429971214e-06 99 1830 True False 12.4336897179253 3.83844487016044 52.389960408037 0.00294851440235881 0.00157086488136083 0.0050367716434693 0.999762216145523 0.999391291831884 0.999935208223951 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 9 6 3 6 3 3780 16043 0.00158478605388272 0.000581803608073282 0.0034461969631646 0.999813037517138 0.999453714469566 0.999961442181588 0.666666666666666 0.29929505620854 0.925145368580308 0.666666666666666 0.29929505620854 0.925145368580308 0.666666666666666 0.29929505620854 0.925145368580308 8.48835978835978 1.81156966816674 52.4815945931853 0.00237862953893587 170 1762 True False 0 0 0 0 0 0 0 8.48835978835978 1.81156966816674 52.4815945931853 0.00158478605388272 0.000581803608073282 0.0034461969631646 0.999813037517138 0.999453714469566 0.999961442181588 28 Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Phe58Ser pncA_p.Phe58Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.716637886286628 Inf 0.0431182613129385 265.5 1830 False False Inf 0.716637886286628 Inf 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 2 2 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.796077158748321 Inf 0.0364363919492442 248 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 24 2) Assoc w R - Interim UP from Uncertain to AwRI yes 4 +Pyrazinamide pncA p.Phe58Val pncA_p.Phe58Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 14 2 12 3 12 4406 16810 0.000680426400544341 0.000140342268876931 0.00198719451371054 0.999286648436571 0.998754250286254 0.999631348241016 0.2 0.0433120051058366 0.480891133806853 0.142857142857142 0.0177945154831915 0.428129160909698 0.142857142857142 0.0177945154831915 0.428129160909698 0.635875321531245 0.0690961734292339 2.85794058136486 0.748043118123898 574 1830 False False 0.953812982296868 0.172646342327914 3.53641980642049 0.000453720508166969 5.49523823434802e-05 0.00163802343880428 0.999286648436571 0.998754250286254 0.999631348241016 3) Uncertain significance 4) Not assoc w R - Interim WHO 4) Not assoc w R - interim 1 14 2 12 3 12 3783 16034 0.000792393026941363 0.000163440311798119 0.00231394549068866 0.999252150068553 0.998694021458847 0.999613517219799 0.2 0.0433120051058366 0.480891133806853 0.142857142857142 0.0177945154831915 0.428129160909698 0.142857142857142 0.0177945154831915 0.428129160909698 0.706405850735747 0.0767563082590848 3.17513652497061 1 927 1762 False False 0 0 0 0 0 0 0 1.05960877610362 0.19178898562654 3.92904399332203 0.000528401585204755 6.39982904626514e-05 0.00190745126237675 0.999252150068553 0.998694021458847 0.999613517219799 10 4) Not assoc w R - Interim UP from Uncertain to NotAwRI yes 4 +Pyrazinamide pncA p.Phe81_His82del pncA_p.Phe81_His82del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Pyrazinamide pncA p.Phe81fs pncA_p.Phe81fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.716637886286628 Inf 0.0431182613129385 265.5 1830 False False Inf 0.716637886286628 Inf 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 2 2 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.796077158748321 Inf 0.0364363919492442 248 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 2 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Phe81Ser pncA_p.Phe81Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 3 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Phe81Val pncA_p.Phe81Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 2 5 2 5 4407 16817 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.999702770181904 0.999306502227134 0.999903483469113 0.285714285714285 0.0366925661760855 0.709579136262657 0.285714285714285 0.0366925661760855 0.709579136262657 0.285714285714285 0.0366925661760855 0.709579136262657 1.52638983435443 0.145279490817154 9.32731563324253 0.640289534516108 568.5 1830 False False 1.52638983435443 0.145279490817154 9.32731563324253 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.999702770181904 0.999306502227134 0.999903483469113 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 2 4 2 4 3784 16042 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999750716689517 0.999361859844744 0.999932074644789 0.333333333333333 0.0432718682927417 0.777221904496487 0.333333333333333 0.0432718682927417 0.777221904496487 0.333333333333333 0.0432718682927417 0.777221904496487 2.11971458773784 0.191662524840198 14.7963495158632 0.322291646278516 458 1762 False False 0 0 0 0 0 0 0 2.11971458773784 0.191662524840198 14.7963495158632 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999750716689517 0.999361859844744 0.999932074644789 11 Assoc w RI 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Pyrazinamide pncA p.Phe94Cys pncA_p.Phe94Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 9 0 9 0 4400 16822 0.00204127920163302 0.000933814369660709 0.00387143149170671 1 0.999780735048249 1 1 0.663732883120057 1 1 0.663732883120057 1 1 0.663732883120057 1 Inf 7.54177743415507 Inf 7.13698843528946e-07 90.5 1830 True False Inf 7.54177743415507 Inf 0.00204127920163302 0.000933814369660709 0.00387143149170671 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 8 8 0 8 0 3778 16046 0.00211304807184363 0.00091269178353604 0.00415927925423806 1 0.999770132403032 1 1 0.63058335244718 1 1 0.63058335244718 1 1 0.63058335244718 1 Inf 7.24385478693174 Inf 1.75352509766709e-06 91 1762 True False 0 0 0 0 0 0 0 Inf 7.24385478693174 Inf 0.00211304807184363 0.00091269178353604 0.00415927925423806 1 0.999770132403032 1 9 Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Phe94fs pncA_p.Phe94fs 1 frameshift (see "Genomic_coordinates" sheet) 1 3 3 0 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 1.57702975056642 Inf 0.00895106588186537 214 1830 False False Inf 1.57702975056642 Inf 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 3 3 0 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 1.75196919627044 Inf 0.00695286470680484 189.5 1762 False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 4 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Phe94Leu pncA_p.Phe94Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 12 9 3 10 3 4399 16819 0.00226808800181447 0.00108815543692413 0.00416712622349087 0.999821662109142 0.999478910338162 0.999963220929399 0.769230769230769 0.461868460765959 0.949618926508848 0.75 0.42814153812181 0.945139355472007 0.75 0.42814153812181 0.945139355472007 11.4701068424641 2.86051282281385 65.9980367734287 8.45064398180301e-05 133 1830 True False 12.7445631582935 3.27895111857834 72.0818533745033 0.00204174228675136 0.000934026308485198 0.00387230895969948 0.999821662109142 0.999478910338162 0.999963220929399 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 9 7 2 8 2 3778 16044 0.00211304807184363 0.00091269178353604 0.00415927925423806 0.999875358344758 0.999549824781286 0.999984904960856 0.8 0.443904537692358 0.974789273673166 0.777777777777777 0.399906426283687 0.971855026522101 0.777777777777777 0.399906426283687 0.971855026522101 14.8634197988353 2.82801189975043 146.588604157245 0.000229730207324084 121 1762 True False 0 0 0 0 0 0 0 16.9867654843832 3.3873087569822 164.067108627238 0.00184940554821664 0.000743870093390834 0.00380674680736097 0.999875358344758 0.999549824781286 0.999984904960856 21 Assoc w R Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Phe94Ser pncA_p.Phe94Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 3 0 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 1.57702975056642 Inf 0.00895106588186537 214 1830 False False Inf 1.57702975056642 Inf 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 3 3 0 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 1.75196919627044 Inf 0.00695286470680484 189.5 1762 False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 7 Assoc w R Assoc w RI 2) Assoc w R - Interim No change yes 1 +Pyrazinamide pncA p.Phe94Tyr pncA_p.Phe94Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA p.Pro115fs pncA_p.Pro115fs 1 frameshift (see "Genomic_coordinates" sheet) 1 4 4 0 4 0 4405 16822 0.000907235200725788 0.000247244623732042 0.00232123869101376 1 0.999780735048249 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 2.51959224712996 Inf 0.00185784794966548 174 1830 True False Inf 2.51959224712996 Inf 0.000907235200725788 0.000247244623732042 0.00232123869101376 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 4 4 0 4 0 3782 16046 0.00105652403592181 0.000287939890647285 0.00270289202199999 1 0.999770132403032 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 2.79918348098377 Inf 0.0013264757267559 157.5 1762 True False 0 0 0 0 0 0 0 Inf 2.79918348098377 Inf 0.00105652403592181 0.000287939890647285 0.00270289202199999 1 0.999770132403032 1 NA 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Pro115Leu pncA_p.Pro115Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Pro115Ser pncA_p.Pro115Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Pro54_Asp56del pncA_p.Pro54_Asp56del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 2 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Pyrazinamide pncA p.Pro54Ala pncA_p.Pro54Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 2 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Pro54Arg pncA_p.Pro54Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 6 0 6 0 4403 16822 0.00136085280108868 0.000499567554195151 0.00295963286153356 1 0.999780735048249 1 1 0.540741873560099 1 1 0.540741873560099 1 1 0.540741873560099 1 Inf 4.49627002862219 Inf 7.99920101998881e-05 128.5 1830 True False Inf 4.49627002862219 Inf 0.00136085280108868 0.000499567554195151 0.00295963286153356 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 6 6 0 6 0 3780 16046 0.00158478605388272 0.000581803608073282 0.0034461969631646 1 0.999770132403032 1 1 0.540741873560099 1 1 0.540741873560099 1 1 0.540741873560099 1 Inf 4.99466385094306 Inf 4.82493639119799e-05 113.5 1762 True False 0 0 0 0 0 0 0 Inf 4.99466385094306 Inf 0.00158478605388272 0.000581803608073282 0.0034461969631646 1 0.999770132403032 1 4 1) Assoc w R UP from Uncertain to AwR yes 4 +Pyrazinamide pncA p.Pro54Gln pncA_p.Pro54Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 3 1 3 1 4406 16821 0.000680426400544341 0.000140342268876931 0.00198719451371054 0.99994055403638 0.999668833292177 0.99999849495964 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 11.4532455742169 0.919224933680734 599.12689591493 0.030230719678465 231.5 1830 False False 11.4532455742169 0.919224933680734 599.12689591493 0.000680426400544341 0.000140342268876931 0.00198719451371054 0.99994055403638 0.999668833292177 0.99999849495964 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 4 3 1 3 1 3783 16045 0.000792393026941363 0.000163440311798119 0.00231394549068866 0.999937679172379 0.999652820032955 0.999998422174497 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 12.7240285487708 1.02115021686679 665.307410149575 0.0238320316469516 213.5 1762 False False 0 0 0 0 0 0 0 12.7240285487708 1.02115021686679 665.307410149575 0.000792393026941363 0.000163440311798119 0.00231394549068866 0.999937679172379 0.999652820032955 0.999998422174497 13 Assoc w RI 2) Assoc w R - Interim No change yes 1 +Pyrazinamide pncA p.Pro54Leu pncA_p.Pro54Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 32 30 2 32 2 4377 16820 0.0072578816058063 0.00496952882236571 0.0102306442081507 0.999881108072762 0.999570588169705 0.999985601311719 0.941176470588235 0.803226790664424 0.99279508256095 0.9375 0.791930570104992 0.992339263653543 0.9375 0.791930570104992 0.992339263653543 57.6422206991089 14.6125676096414 497.250743145039 9.64349224787156e-19 31 1830 True False 61.4850354123829 15.6728013910892 528.894166589364 0.0068073519400953 0.00459746720893424 0.00970376671111439 0.999881108072762 0.999570588169705 0.999985601311719 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 29 27 2 27 2 3759 16044 0.00713153724247226 0.00470483491393888 0.0103591696773319 0.999875358344758 0.999549824781286 0.999984904960856 0.93103448275862 0.772338110055513 0.991536037746998 0.93103448275862 0.772338110055513 0.991536037746998 0.93103448275862 0.772338110055513 0.991536037746998 57.6201117318435 14.4630054707457 499.488230181482 9.60025281053801e-18 26 1762 True False 0 0 0 0 0 0 0 57.6201117318435 14.4630054707457 499.488230181482 0.00713153724247226 0.00470483491393888 0.0103591696773319 0.999875358344758 0.999549824781286 0.999984904960856 53 Assoc w R Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Pro54Ser pncA_p.Pro54Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 3 0 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 1.57702975056642 Inf 0.00895106588186537 214 1830 False False Inf 1.57702975056642 Inf 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 3 3 0 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 1.75196919627044 Inf 0.00695286470680484 189.5 1762 False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 21 2) Assoc w R - Interim UP from Uncertain to AwRI yes 4 +Pyrazinamide pncA p.Pro54Thr pncA_p.Pro54Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 2 1 2 1 4407 16821 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.99994055403638 0.999668833292177 0.99999849495964 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 7.63376446562287 0.397281353658273 449.052313013199 0.111452652175084 308.5 1830 False False 7.63376446562287 0.397281353658273 449.052313013199 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.99994055403638 0.999668833292177 0.99999849495964 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 3 2 1 2 1 3784 16045 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999937679172379 0.999652820032955 0.999998422174497 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 8.48044397463002 0.441282441622781 498.676520130596 0.0954034464341229 286.5 1762 False False 0 0 0 0 0 0 0 8.48044397463002 0.441282441622781 498.676520130596 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999937679172379 0.999652820032955 0.999998422174497 NA 2) Assoc w R - Interim New AwRI yes 5 +Pyrazinamide pncA p.Pro62Arg pncA_p.Pro62Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 4 0 4 0 4405 16822 0.000907235200725788 0.000247244623732042 0.00232123869101376 1 0.999780735048249 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 2.51959224712996 Inf 0.00185784794966548 174 1830 True False Inf 2.51959224712996 Inf 0.000907235200725788 0.000247244623732042 0.00232123869101376 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 3 3 0 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 1.75196919627044 Inf 0.00695286470680484 189.5 1762 False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 4 2) Assoc w R - Interim UP from Uncertain to AwRI yes 4 +Pyrazinamide pncA p.Pro62Gln pncA_p.Pro62Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 2 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Pro62Leu pncA_p.Pro62Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 11 10 1 10 1 4399 16821 0.00226808800181447 0.00108815543692413 0.00416712622349087 0.99994055403638 0.999668833292177 0.99999849495964 0.909090909090909 0.587220083011617 0.997701027786185 0.909090909090909 0.587220083011617 0.997701027786185 0.909090909090909 0.587220083011617 0.997701027786185 38.2382359627188 5.43632314626283 1645.1103984026 1.32095946640665e-06 97.5 1830 True False 38.2382359627188 5.43632314626283 1645.1103984026 0.00226808800181447 0.00108815543692413 0.00416712622349087 0.99994055403638 0.999668833292177 0.99999849495964 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 10 9 1 9 1 3777 16045 0.00237717908082408 0.00108755584228183 0.00450780893694816 0.999937679172379 0.999652820032955 0.999998422174497 0.9 0.554983882971804 0.997471421455538 0.9 0.554983882971804 0.997471421455538 0.9 0.554983882971804 0.997471421455538 38.232724384432 5.29419450309442 1660.92197563144 2.76875337693198e-06 96 1762 True False 0 0 0 0 0 0 0 38.232724384432 5.29419450309442 1660.92197563144 0.00237717908082408 0.00108755584228183 0.00450780893694816 0.999937679172379 0.999652820032955 0.999998422174497 38 Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Pro62Ser pncA_p.Pro62Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 3 1 3 2 4406 16820 0.000680426400544341 0.000140342268876931 0.00198719451371054 0.999881108072762 0.999570588169705 0.999985601311719 0.6 0.146632799634673 0.947255049473683 0.75 0.194120449683243 0.99369053679029 0.6 0.146632799634673 0.947255049473683 11.4525646845211 0.919170284099466 599.091422582261 0.0302347293621333 235 1830 False False 5.72628234226055 0.655677739135472 68.675028521871 0.000680426400544341 0.000140342268876931 0.00198719451371054 0.999881108072762 0.999570588169705 0.999985601311719 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 4 3 1 3 2 3783 16044 0.000792393026941363 0.000163440311798119 0.00231394549068866 0.999875358344758 0.999549824781286 0.999984904960856 0.6 0.146632799634673 0.947255049473683 0.75 0.194120449683243 0.99369053679029 0.6 0.146632799634673 0.947255049473683 12.7232355273592 1.02108656608204 665.266133418385 0.0238354365521396 218 1762 False False 0 0 0 0 0 0 0 6.36161776367961 0.728392675067714 76.0575760881352 0.000792393026941363 0.000163440311798119 0.00231394549068866 0.999875358344758 0.999549824781286 0.999984904960856 7 Assoc w RI 2) Assoc w R - Interim No change yes 1 +Pyrazinamide pncA p.Pro62Thr pncA_p.Pro62Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 3 0 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 1.57702975056642 Inf 0.00895106588186537 214 1830 False False Inf 1.57702975056642 Inf 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 3 3 0 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 1.75196919627044 Inf 0.00695286470680484 189.5 1762 False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 6 Assoc w RI 2) Assoc w R - Interim No change yes 1 +Pyrazinamide pncA p.Pro69Arg pncA_p.Pro69Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 8 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Pro69Leu pncA_p.Pro69Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 19 14 5 14 5 4395 16817 0.00317532320254025 0.00173703251080297 0.00532191922970533 0.999702770181904 0.999306502227134 0.999903483469113 0.736842105263157 0.487970654654127 0.908534215092333 0.736842105263157 0.487970654654127 0.908534215092333 0.736842105263157 0.487970654654127 0.908534215092333 10.7139021615472 3.64323216971744 38.0193542476103 1.08675394642264e-06 96 1830 True False 10.7139021615472 3.64323216971744 38.0193542476103 0.00317532320254025 0.00173703251080297 0.00532191922970533 0.999702770181904 0.999306502227134 0.999903483469113 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 19 14 5 14 5 3772 16041 0.00369783412572636 0.00202306972195899 0.00619656153938766 0.999688395861897 0.99927297097682 0.999898815491092 0.736842105263157 0.487970654654127 0.908534215092333 0.736842105263157 0.487970654654127 0.908534215092333 0.736842105263157 0.487970654654127 0.908534215092333 11.9074231177094 4.04871705317325 42.2815029097583 3.66967993953364e-07 82.5 1762 True False 0 0 0 0 0 0 0 11.9074231177094 4.04871705317325 42.2815029097583 0.00369783412572636 0.00202306972195899 0.00619656153938766 0.999688395861897 0.99927297097682 0.999898815491092 17 Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Pro69Ser pncA_p.Pro69Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 1 5 1 5 4408 16817 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999702770181904 0.999306502227134 0.999903483469113 0.166666666666666 0.00421074451448947 0.641234578997674 0.166666666666666 0.00421074451448947 0.641234578997674 0.166666666666666 0.00421074451448947 0.641234578997674 0.763021778584392 0.0161324685427033 6.82117624035202 1 1273 1830 False False 0.763021778584392 0.0161324685427033 6.82117624035202 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999702770181904 0.999306502227134 0.999903483469113 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 1 2 3785 16044 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999875358344758 0.999549824781286 0.999984904960856 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 2.11941875825627 0.0359146288488272 40.7195918479678 0.470354459331036 493.5 1762 False False 0 0 0 0 0 0 0 2.11941875825627 0.0359146288488272 40.7195918479678 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999875358344758 0.999549824781286 0.999984904960856 13 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Pro69Thr pncA_p.Pro69Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA p.Pro77Leu pncA_p.Pro77Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Pro83fs pncA_p.Pro83fs 1 frameshift (see "Genomic_coordinates" sheet) 1 3 3 0 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 1.57702975056642 Inf 0.00895106588186537 214 1830 False False Inf 1.57702975056642 Inf 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 3 3 0 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 1.75196919627044 Inf 0.00695286470680484 189.5 1762 False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 NA 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Ser104_Gly108delinsArg pncA_p.Ser104_Gly108delinsArg 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.716637886286628 Inf 0.0431182613129385 265.5 1830 False False Inf 0.716637886286628 Inf 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 2 2 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.796077158748321 Inf 0.0364363919492442 248 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 NA 2) Assoc w R - Interim No change yes 1 +Pyrazinamide pncA p.Ser104Arg pncA_p.Ser104Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 7 0 7 0 4402 16822 0.00158766160127012 0.000638553061192671 0.00326843667440656 1 0.999780735048249 1 1 0.590383602774996 1 1 0.590383602774996 1 1 0.590383602774996 1 Inf 5.50478416804174 Inf 1.65938667095456e-05 115.5 1830 True False Inf 5.50478416804174 Inf 0.00158766160127012 0.000638553061192671 0.00326843667440656 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 6 6 0 6 0 3780 16046 0.00158478605388272 0.000581803608073282 0.0034461969631646 1 0.999770132403032 1 1 0.540741873560099 1 1 0.540741873560099 1 1 0.540741873560099 1 Inf 4.99466385094306 Inf 4.82493639119799e-05 113.5 1762 True False 0 0 0 0 0 0 0 Inf 4.99466385094306 Inf 0.00158478605388272 0.000581803608073282 0.0034461969631646 1 0.999770132403032 1 51 Assoc w R Assoc w RI 1) Assoc w R UP from AwRI to AwR yes 4 +Pyrazinamide pncA p.Ser104Gly pncA_p.Ser104Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 2 1 2 1 4407 16821 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.99994055403638 0.999668833292177 0.99999849495964 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 7.63376446562287 0.397281353658273 449.052313013199 0.111452652175084 308.5 1830 False False 7.63376446562287 0.397281353658273 449.052313013199 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.99994055403638 0.999668833292177 0.99999849495964 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 3 2 1 2 1 3784 16045 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999937679172379 0.999652820032955 0.999998422174497 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 8.48044397463002 0.441282441622781 498.676520130596 0.0954034464341229 286.5 1762 False False 0 0 0 0 0 0 0 8.48044397463002 0.441282441622781 498.676520130596 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999937679172379 0.999652820032955 0.999998422174497 1 2) Assoc w R - Interim UP from Uncertain to AwRI yes 4 +Pyrazinamide pncA p.Ser104Ile pncA_p.Ser104Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.716637886286628 Inf 0.0431182613129385 265.5 1830 False False Inf 0.716637886286628 Inf 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 2 2 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.796077158748321 Inf 0.0364363919492442 248 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 Assoc w RI 2) Assoc w R - Interim No change yes 1 +Pyrazinamide pncA p.Ser104Thr pncA_p.Ser104Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Ser164fs pncA_p.Ser164fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 4 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Ser164Pro pncA_p.Ser164Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 13 12 1 12 1 4397 16821 0.00272170560217736 0.00140711126319081 0.00474944049676375 0.99994055403638 0.999668833292177 0.99999849495964 0.923076923076923 0.639702564732122 0.998054371502653 0.923076923076923 0.639702564732122 0.998054371502653 0.923076923076923 0.639702564732122 0.998054371502653 45.9067546054127 6.78733808586374 1942.29819734014 6.6837605835208e-08 70 1830 True False 45.9067546054127 6.78733808586374 1942.29819734014 0.00272170560217736 0.00140711126319081 0.00474944049676375 0.99994055403638 0.999668833292177 0.99999849495964 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 10 9 1 9 1 3777 16045 0.00237717908082408 0.00108755584228183 0.00450780893694816 0.999937679172379 0.999652820032955 0.999998422174497 0.9 0.554983882971804 0.997471421455538 0.9 0.554983882971804 0.997471421455538 0.9 0.554983882971804 0.997471421455538 38.232724384432 5.29419450309442 1660.92197563144 2.76875337693198e-06 96 1762 True False 0 0 0 0 0 0 0 38.232724384432 5.29419450309442 1660.92197563144 0.00237717908082408 0.00108755584228183 0.00450780893694816 0.999937679172379 0.999652820032955 0.999998422174497 47 Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Ser164* pncA_p.Ser164* 1 stop_gained (see "Genomic_coordinates" sheet) 1 4 3 1 3 1 4406 16821 0.000680426400544341 0.000140342268876931 0.00198719451371054 0.99994055403638 0.999668833292177 0.99999849495964 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 11.4532455742169 0.919224933680734 599.12689591493 0.030230719678465 231.5 1830 False False 11.4532455742169 0.919224933680734 599.12689591493 0.000680426400544341 0.000140342268876931 0.00198719451371054 0.99994055403638 0.999668833292177 0.99999849495964 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 4 3 1 3 1 3783 16045 0.000792393026941363 0.000163440311798119 0.00231394549068866 0.999937679172379 0.999652820032955 0.999998422174497 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 12.7240285487708 1.02115021686679 665.307410149575 0.0238320316469516 213.5 1762 False False 0 0 0 0 0 0 0 12.7240285487708 1.02115021686679 665.307410149575 0.000792393026941363 0.000163440311798119 0.00231394549068866 0.999937679172379 0.999652820032955 0.999998422174497 24 Assoc w R Assoc w RI 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Ser179Ile pncA_p.Ser179Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Ser18_Val44del pncA_p.Ser18_Val44del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Pyrazinamide pncA p.Ser18fs pncA_p.Ser18fs 1 frameshift (see "Genomic_coordinates" sheet) 1 4 3 1 3 1 4406 16821 0.000680426400544341 0.000140342268876931 0.00198719451371054 0.99994055403638 0.999668833292177 0.99999849495964 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 11.4532455742169 0.919224933680734 599.12689591493 0.030230719678465 231.5 1830 False False 11.4532455742169 0.919224933680734 599.12689591493 0.000680426400544341 0.000140342268876931 0.00198719451371054 0.99994055403638 0.999668833292177 0.99999849495964 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 4 3 1 3 1 3783 16045 0.000792393026941363 0.000163440311798119 0.00231394549068866 0.999937679172379 0.999652820032955 0.999998422174497 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 12.7240285487708 1.02115021686679 665.307410149575 0.0238320316469516 213.5 1762 False False 0 0 0 0 0 0 0 12.7240285487708 1.02115021686679 665.307410149575 0.000792393026941363 0.000163440311798119 0.00231394549068866 0.999937679172379 0.999652820032955 0.999998422174497 19 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Ser18Pro pncA_p.Ser18Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Ser18* pncA_p.Ser18* 1 stop_gained (see "Genomic_coordinates" sheet) 1 7 4 3 5 3 4404 16819 0.00113404400090723 0.000368320285107068 0.00264447958048867 0.999821662109142 0.999478910338162 0.999963220929399 0.625 0.244863216366551 0.914766585862746 0.571428571428571 0.184051567640083 0.901011721557492 0.571428571428571 0.184051567640083 0.901011721557492 5.09203754162882 0.861035192325872 34.7598469609662 0.0378837634525416 238 1830 False False 6.36504692703602 1.23768373585682 41.0231847707768 0.000907441016333938 0.0002473007258695 0.00232176491492765 0.999821662109142 0.999478910338162 0.999963220929399 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 6 3 3 4 3 3782 16043 0.00105652403592181 0.000287939890647285 0.00270289202199999 0.999813037517138 0.999453714469566 0.999961442181588 0.571428571428571 0.184051567640083 0.901011721557492 0.5 0.118117248757025 0.881882751242974 0.5 0.118117248757025 0.881882751242974 4.24193548387096 0.567883899777812 31.6811916827074 0.0879445953612917 277 1762 False False 0 0 0 0 0 0 0 5.65591397849462 0.956294414486511 38.6546126488754 0.000792602377807133 0.000163483500741026 0.00231455637111671 0.999813037517138 0.999453714469566 0.999961442181588 5 Assoc w R Assoc w RI 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Ser32fs pncA_p.Ser32fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Ser32Ile pncA_p.Ser32Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 NA 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Ser59Phe pncA_p.Ser59Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 6 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Ser59Pro pncA_p.Ser59Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 24 24 0 24 0 4385 16822 0.00544341120435472 0.00349071725023238 0.0080886043215741 1 0.999780735048249 1 1 0.857526402277474 1 1 0.857526402277474 1 1 0.857526402277474 1 Inf 23.073844353815 Inf 3.93807955232743e-17 33 1830 True False Inf 23.073844353815 Inf 0.00544341120435472 0.00349071725023238 0.0080886043215741 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 23 23 0 23 0 3763 16046 0.00607501320655044 0.00385481943701651 0.00910163900404459 1 0.999770132403032 1 1 0.851814871084775 1 1 0.851814871084775 1 1 0.851814871084775 1 Inf 24.4874308459603 Inf 2.72387523251018e-17 27 1762 True False 0 0 0 0 0 0 0 Inf 24.4874308459603 Inf 0.00607501320655044 0.00385481943701651 0.00910163900404459 1 0.999770132403032 1 32 Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Ser65fs pncA_p.Ser65fs 1 frameshift (see "Genomic_coordinates" sheet) 1 7 6 1 6 1 4403 16821 0.00136085280108868 0.000499567554195151 0.00295963286153356 0.99994055403638 0.999668833292177 0.99999849495964 0.857142857142857 0.421276802956804 0.996389703138099 0.857142857142857 0.421276802956804 0.996389703138099 0.857142857142857 0.421276802956804 0.996389703138099 22.9220985691573 2.7794245182276 1048.43039728317 0.000460380871141943 155.5 1830 True False 22.9220985691573 2.7794245182276 1048.43039728317 0.00136085280108868 0.000499567554195151 0.00295963286153356 0.99994055403638 0.999668833292177 0.99999849495964 1) Assoc w R 2) Assoc w R - Interim WHO 2) Assoc w R - Interim 1 4 3 1 3 1 3783 16045 0.000792393026941363 0.000163440311798119 0.00231394549068866 0.999937679172379 0.999652820032955 0.999998422174497 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 12.7240285487708 1.02115021686679 665.307410149575 0.0238320316469516 213.5 1762 False False 0 0 0 0 0 0 0 12.7240285487708 1.02115021686679 665.307410149575 0.000792393026941363 0.000163440311798119 0.00231394549068866 0.999937679172379 0.999652820032955 0.999998422174497 26 Interim based on WHO dataset 2) Assoc w R - Interim No change no Interim on WHO 1 +Pyrazinamide pncA p.Ser65Pro pncA_p.Ser65Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 8 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Ser66Ala pncA_p.Ser66Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA p.Ser66del pncA_p.Ser66del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Pyrazinamide pncA p.Ser66Leu pncA_p.Ser66Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 0 9 0 9 4409 16813 0 0 0.000836320411980403 0.999464986327428 0.998984621445092 0.999755329427402 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.336267116879942 0 0 1.9328143827158 0.219086249473785 468 1830 False False 0 0 1.9328143827158 0 0 0.000836320411980403 0.999464986327428 0.998984621445092 0.999755329427402 3) Uncertain significance 4) Not assoc w R - Interim WHO 4) Not assoc w R - interim 1 8 0 8 0 8 3786 16038 0 0 0.000973872929872615 0.999501433379035 0.999017862631239 0.999784730530787 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 2.48286669292342 0.36696353836705 478 1762 False False 0 0 0 0 0 0 0 0 0 2.48286669292342 0 0 0.000973872929872615 0.999501433379035 0.999017862631239 0.999784730530787 7 Not assoc w RI 4) Not assoc w R - Interim No change yes 1 +Pyrazinamide pncA p.Ser66Pro pncA_p.Ser66Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 6 0 6 0 4403 16822 0.00136085280108868 0.000499567554195151 0.00295963286153356 1 0.999780735048249 1 1 0.540741873560099 1 1 0.540741873560099 1 1 0.540741873560099 1 Inf 4.49627002862219 Inf 7.99920101998881e-05 128.5 1830 True False Inf 4.49627002862219 Inf 0.00136085280108868 0.000499567554195151 0.00295963286153356 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 5 5 0 5 0 3781 16046 0.00132065504490227 0.000428947757354115 0.0030792549559865 1 0.999770132403032 1 1 0.478176249895018 1 1 0.478176249895018 1 1 0.478176249895018 1 Inf 3.88652681138742 Inf 0.000253012467147004 128 1762 True False 0 0 0 0 0 0 0 Inf 3.88652681138742 Inf 0.00132065504490227 0.000428947757354115 0.0030792549559865 1 0.999770132403032 1 5 1) Assoc w R UP from Uncertain to AwR yes 4 +Pyrazinamide pncA p.Ser66* pncA_p.Ser66* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 Assoc w R Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Ser67Pro pncA_p.Ser67Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 21 21 0 22 0 4387 16822 0.00498979360399183 0.00312963962508212 0.00754491629562881 1 0.999780735048249 1 1 0.845627487184425 1 1 0.83890238478092 1 1 0.83890238478092 1 Inf 19.952036009311 Inf 4.43300765822899e-15 36 1830 True False Inf 20.9881300139997 Inf 0.00476406533575317 0.00295137747620844 0.00727320768834272 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 19 19 0 20 0 3766 16046 0.00528262017960908 0.00322965810863289 0.00814684323786685 1 0.999770132403032 1 1 0.831566529016914 1 1 0.823533088193034 1 1 0.823533088193034 1 Inf 19.8664226287239 Inf 2.07872671158726e-14 30 1762 True False 0 0 0 0 0 0 0 Inf 21.0169304362191 Inf 0.00501981505944517 0.00302488086520661 0.00782801026647128 1 0.999770132403032 1 36 Assoc w R Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Ser67* pncA_p.Ser67* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 NA Assoc w R Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Ser67Trp pncA_p.Ser67Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 1 2 4408 16820 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999881108072762 0.999570588169705 0.999985601311719 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 1.9078947368421 0.0323314320919459 36.6634061310851 0.502600379724595 526 1830 False False 1.9078947368421 0.0323314320919459 36.6634061310851 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 1 2 3785 16044 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999875358344758 0.999549824781286 0.999984904960856 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 2.11941875825627 0.0359146288488272 40.7195918479678 0.470354459331036 493.5 1762 False False 0 0 0 0 0 0 0 2.11941875825627 0.0359146288488272 40.7195918479678 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999875358344758 0.999549824781286 0.999984904960856 11 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Ser74_Pro77del pncA_p.Ser74_Pro77del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Pyrazinamide pncA p.Ser74fs pncA_p.Ser74fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.716637886286628 Inf 0.0431182613129385 265.5 1830 False False Inf 0.716637886286628 Inf 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 NA 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Ser84fs pncA_p.Ser84fs 1 frameshift (see "Genomic_coordinates" sheet) 1 9 9 0 9 0 4400 16822 0.00204127920163302 0.000933814369660709 0.00387143149170671 1 0.999780735048249 1 1 0.663732883120057 1 1 0.663732883120057 1 1 0.663732883120057 1 Inf 7.54177743415507 Inf 7.13698843528946e-07 90.5 1830 True False Inf 7.54177743415507 Inf 0.00204127920163302 0.000933814369660709 0.00387143149170671 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 9 9 0 9 0 3777 16046 0.00237717908082408 0.00108755584228183 0.00450780893694816 1 0.999770132403032 1 1 0.663732883120057 1 1 0.663732883120057 1 1 0.663732883120057 1 Inf 8.37964612204265 Inf 3.34181689819727e-07 76.5 1762 True False 0 0 0 0 0 0 0 Inf 8.37964612204265 Inf 0.00237717908082408 0.00108755584228183 0.00450780893694816 1 0.999770132403032 1 2 1) Assoc w R UP from AwRI to AwR yes 4 +Pyrazinamide pncA p.Ter187Argext*? pncA_p.Ter187Argext*? 1 stop_lost (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.716637886286628 Inf 0.0431182613129385 265.5 1830 False False Inf 0.716637886286628 Inf 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 2 2 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.796077158748321 Inf 0.0364363919492442 248 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 5 2) Assoc w R - Interim New AwRI yes 5 +Pyrazinamide pncA p.Ter187Glyext*? pncA_p.Ter187Glyext*? 1 stop_lost (see "Genomic_coordinates" sheet) 1 3 1 2 2 2 4407 16820 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.999881108072762 0.999570588169705 0.999985601311719 0.5 0.067585986488543 0.932414013511457 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 1.90832766054005 0.0323387668486046 36.671823741687 0.502530085826874 520.5 1830 False False 3.8166553210801 0.276553001924986 52.6392074577436 0.000226860254083484 5.74358785768897e-06 0.0012633291757201 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 2 2 3784 16044 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999875358344758 0.999549824781286 0.999984904960856 0.5 0.067585986488543 0.932414013511457 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 2.11997885835095 0.0359241175697613 40.7303511527588 0.470274327371684 487.5 1762 False False 0 0 0 0 0 0 0 4.2399577167019 0.307210542317908 58.5302826936734 0.000264200792602377 6.68896256519433e-06 0.00147114392376758 0.999875358344758 0.999549824781286 0.999984904960856 22 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA p.Ter187Trpext*? pncA_p.Ter187Trpext*? 1 stop_lost (see "Genomic_coordinates" sheet) 1 5 4 1 4 1 4405 16821 0.000907235200725788 0.000247244623732042 0.00232123869101376 0.99994055403638 0.999668833292177 0.99999849495964 0.8 0.28358206388191 0.994949236620532 0.8 0.28358206388191 0.994949236620532 0.8 0.28358206388191 0.994949236620532 15.2744608399545 1.5107888308703 749.051486258063 0.00774708678874264 197 1830 False False 15.2744608399545 1.5107888308703 749.051486258063 0.000907235200725788 0.000247244623732042 0.00232123869101376 0.99994055403638 0.999668833292177 0.99999849495964 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 4 3 1 3 1 3783 16045 0.000792393026941363 0.000163440311798119 0.00231394549068866 0.999937679172379 0.999652820032955 0.999998422174497 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 12.7240285487708 1.02115021686679 665.307410149575 0.0238320316469516 213.5 1762 False False 0 0 0 0 0 0 0 12.7240285487708 1.02115021686679 665.307410149575 0.000792393026941363 0.000163440311798119 0.00231394549068866 0.999937679172379 0.999652820032955 0.999998422174497 24 2) Assoc w R - Interim New AwRI yes 5 +Pyrazinamide pncA p.Thr100Ile pncA_p.Thr100Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 3 2 4406 16820 0.000680426400544341 0.000140342268876931 0.00198719451371054 0.999881108072762 0.999570588169705 0.999985601311719 0.6 0.146632799634673 0.947255049473683 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3364887083506 1 1273 1830 False False 5.72628234226055 0.655677739135472 68.675028521871 0 0 0.000836889615584862 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 1 3783 16045 0.000792393026941363 0.000163440311798119 0.00231394549068866 0.999937679172379 0.999652820032955 0.999998422174497 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 164.998781320348 1 927 1762 False False 0 0 0 0 0 0 0 12.7240285487708 1.02115021686679 665.307410149575 0 0 0.000974644855475749 0.999937679172379 0.999652820032955 0.999998422174497 57 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Thr100Pro pncA_p.Thr100Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 3 0 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 1.57702975056642 Inf 0.00895106588186537 214 1830 False False Inf 1.57702975056642 Inf 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 2 2 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.796077158748321 Inf 0.0364363919492442 248 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 33 2) Assoc w R - Interim UP from Uncertain to AwRI yes 4 +Pyrazinamide pncA p.Thr114fs pncA_p.Thr114fs 1 frameshift (see "Genomic_coordinates" sheet) 1 4 4 0 4 0 4405 16822 0.000907235200725788 0.000247244623732042 0.00232123869101376 1 0.999780735048249 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 2.51959224712996 Inf 0.00185784794966548 174 1830 True False Inf 2.51959224712996 Inf 0.000907235200725788 0.000247244623732042 0.00232123869101376 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 4 4 0 4 0 3782 16046 0.00105652403592181 0.000287939890647285 0.00270289202199999 1 0.999770132403032 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 2.79918348098377 Inf 0.0013264757267559 157.5 1762 True False 0 0 0 0 0 0 0 Inf 2.79918348098377 Inf 0.00105652403592181 0.000287939890647285 0.00270289202199999 1 0.999770132403032 1 4 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Thr114Met pncA_p.Thr114Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 7 4409 16815 0 0 0.000836320411980403 0.999583878254666 0.99914281931165 0.999832681632407 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 2.64713852578052 0.357432235618625 497.5 1830 False False 0 0 2.64713852578052 0 0 0.000836320411980403 0.999583878254666 0.99914281931165 0.999832681632407 3) Uncertain significance 4) Not assoc w R - Interim WHO 4) Not assoc w R - interim 1 3 0 3 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 10.2590571436125 1 554.5 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 26 Not assoc w RI 4) Not assoc w R - Interim No change yes 1 +Pyrazinamide pncA p.Thr114Pro pncA_p.Thr114Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.716637886286628 Inf 0.0431182613129385 265.5 1830 False False Inf 0.716637886286628 Inf 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 2 2 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.796077158748321 Inf 0.0364363919492442 248 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 2) Assoc w R - Interim UP from Uncertain to AwRI yes 4 +Pyrazinamide pncA p.Thr135Ala pncA_p.Thr135Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 4407 16821 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.99994055403638 0.999668833292177 0.99999849495964 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 148.524102705736 1 1273 1830 False False 7.63376446562287 0.397281353658273 449.052313013199 0 0 0.000836699794980095 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Thr135Asn pncA_p.Thr135Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.716637886286628 Inf 0.0431182613129385 265.5 1830 False False Inf 0.716637886286628 Inf 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 2 2 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.796077158748321 Inf 0.0364363919492442 248 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 NA Assoc w R Assoc w RI 2) Assoc w R - Interim No change yes 1 +Pyrazinamide pncA p.Thr135Ile pncA_p.Thr135Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Thr135Pro pncA_p.Thr135Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 44 43 1 43 1 4366 16821 0.00975277840780222 0.00706687257233482 0.0131146729814392 0.99994055403638 0.999668833292177 0.99999849495964 0.977272727272727 0.879758417793652 0.999424760786636 0.977272727272727 0.879758417793652 0.999424760786636 0.977272727272727 0.879758417793652 0.999424760786636 165.667201099404 28.1560309900219 6420.79434730621 1.32415538882354e-28 16 1830 True False 165.667201099404 28.1560309900219 6420.79434730621 0.00975277840780222 0.00706687257233482 0.0131146729814392 0.99994055403638 0.999668833292177 0.99999849495964 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 31 30 1 30 1 3756 16045 0.00792393026941363 0.00535244448152805 0.0112927265285391 0.999937679172379 0.999652820032955 0.999998422174497 0.967741935483871 0.832978883769772 0.999183629928153 0.967741935483871 0.832978883769772 0.999183629928153 0.967741935483871 0.832978883769772 0.999183629928153 128.154952076677 21.287281211528 5067.92262901939 6.12647543385134e-21 21 1762 True False 0 0 0 0 0 0 0 128.154952076677 21.287281211528 5067.92262901939 0.00792393026941363 0.00535244448152805 0.0112927265285391 0.999937679172379 0.999652820032955 0.999998422174497 67 Assoc w R Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Thr142Ala pncA_p.Thr142Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 15 13 2 14 2 4395 16820 0.00317532320254025 0.00173703251080297 0.00532191922970533 0.999881108072762 0.999570588169705 0.999985601311719 0.875 0.616523763150736 0.984486396184586 0.866666666666666 0.595397303396627 0.983424086559916 0.866666666666666 0.595397303396627 0.983424086559916 24.8759954493742 5.62762128989528 226.142440750153 9.004361789021e-08 71 1830 True False 26.7895335608646 6.14738704212583 241.631538217096 0.00294918330308529 0.00157122145379172 0.00503791308918907 0.999881108072762 0.999570588169705 0.999985601311719 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 13 11 2 12 2 3774 16044 0.00316957210776545 0.00163880353722015 0.00553005230777549 0.999875358344758 0.999549824781286 0.999984904960856 0.857142857142857 0.571870839090301 0.982205484516808 0.846153846153846 0.545528944323442 0.980793328017471 0.846153846153846 0.545528944323442 0.980793328017471 23.3815580286168 5.09871132510921 216.374078737506 6.43330428405084e-07 85 1762 True False 0 0 0 0 0 0 0 25.5071542130365 5.67374597729496 233.622034678001 0.00290620871862615 0.00145163402736959 0.00519404683685885 0.999875358344758 0.999549824781286 0.999984904960856 37 Assoc w R Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Thr142Lys pncA_p.Thr142Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.716637886286628 Inf 0.0431182613129385 265.5 1830 False False Inf 0.716637886286628 Inf 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 2 2 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.796077158748321 Inf 0.0364363919492442 248 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 8 Assoc w R Assoc w RI 2) Assoc w R - Interim No change yes 1 +Pyrazinamide pncA p.Thr142Met pncA_p.Thr142Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 13 12 1 13 1 4396 16821 0.00294851440235881 0.00157086488136083 0.0050367716434693 0.99994055403638 0.999668833292177 0.99999849495964 0.928571428571428 0.661315510068178 0.998193219340874 0.923076923076923 0.639702564732122 0.998054371502653 0.923076923076923 0.639702564732122 0.998054371502653 45.9171974522293 6.78888083049413 1942.7347380485 6.66962336722968e-08 69 1830 True False 49.7436305732484 7.46696225360555 2090.58078435287 0.00272232304900181 0.00140743065487038 0.00475051685977866 0.99994055403638 0.999668833292177 0.99999849495964 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 13 12 1 13 1 3773 16045 0.0034337031167459 0.00182953006918454 0.00586457926930979 0.999937679172379 0.999652820032955 0.999998422174497 0.928571428571428 0.661315510068178 0.998193219340874 0.923076923076923 0.639702564732122 0.998054371502653 0.923076923076923 0.639702564732122 0.998054371502653 51.03100980652 7.54471654865676 2156.19112577774 2.46907218516339e-08 63 1762 True False 0 0 0 0 0 0 0 55.2835939570633 8.29679179515425 2320.00990633012 0.00317040951122853 0.00163923678543461 0.00553151162049234 0.999937679172379 0.999652820032955 0.999998422174497 28 Assoc w R Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Thr142Pro pncA_p.Thr142Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.716637886286628 Inf 0.0431182613129385 265.5 1830 False False Inf 0.716637886286628 Inf 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 5 2) Assoc w R - Interim UP from Uncertain to AwRI yes 4 +Pyrazinamide pncA p.Thr153fs pncA_p.Thr153fs 1 frameshift (see "Genomic_coordinates" sheet) 1 37 35 2 35 2 4374 16820 0.00793830800635064 0.00553537226062617 0.0110231268596098 0.999881108072762 0.999570588169705 0.999985601311719 0.945945945945946 0.81805088162225 0.993385429588471 0.945945945945946 0.81805088162225 0.993385429588471 0.945945945945946 0.81805088162225 0.993385429588471 67.2953818015546 17.2767272090098 576.773613665224 4.90164884401557e-22 24 1830 True False 67.2953818015546 17.2767272090098 576.773613665224 0.00793830800635064 0.00553537226062617 0.0110231268596098 0.999881108072762 0.999570588169705 0.999985601311719 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 30 30 0 30 0 3756 16046 0.00792393026941363 0.00535244448152805 0.0112927265285391 1 0.999770132403032 1 1 0.884296691777972 1 1 0.884296691777972 1 1 0.884296691777972 1 Inf 32.6187400762477 Inf 2.42060701583706e-22 18 1762 True False 0 0 0 0 0 0 0 Inf 32.6187400762477 Inf 0.00792393026941363 0.00535244448152805 0.0112927265285391 1 0.999770132403032 1 75 1) Assoc w R UP from AwRI to AwR yes 4 +Pyrazinamide pncA p.Thr153Pro pncA_p.Thr153Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Thr160_Ala171del pncA_p.Thr160_Ala171del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Pyrazinamide pncA p.Thr160Ala pncA_p.Thr160Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 4 3 4405 16819 0.000907235200725788 0.000247244623732042 0.00232123869101376 0.999821662109142 0.999478910338162 0.999963220929399 0.571428571428571 0.184051567640083 0.901011721557492 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.24393707049781 1 1273 1830 False False 5.09088157396897 0.860839946405004 34.751883944255 0 0 0.000837079522337697 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 4) Not assoc w R - Interim WHO 4) Not assoc w R - interim 1 3 0 3 3 3 3783 16043 0.000792393026941363 0.000163440311798119 0.00231394549068866 0.999813037517138 0.999453714469566 0.999961442181588 0.5 0.118117248757025 0.881882751242974 0 0 0.707598226178713 0 0 0.707598226178713 0 0 10.2671914147985 1 927 1762 False False 0 0 0 0 0 0 0 4.24081416864922 0.567733907706636 31.6728249153222 0 0 0.000974644855475749 0.999813037517138 0.999453714469566 0.999961442181588 69 4) Not assoc w R - Interim UP from Uncertain to NotAwRI yes 4 +Pyrazinamide pncA p.Thr160Arg pncA_p.Thr160Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.097852308370781 Inf 0.207630711257654 334.5 1830 False False Inf 0.716637886286628 Inf 0.000226860254083484 5.74358785768897e-06 0.0012633291757201 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.108701618838585 Inf 0.190862790580404 314.5 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0.000264200792602377 6.68896256519433e-06 0.00147114392376758 1 0.999770132403032 1 2 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Thr160Lys pncA_p.Thr160Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.716637886286628 Inf 0.0431182613129385 265.5 1830 False False Inf 0.716637886286628 Inf 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 7 2) Assoc w R - Interim New AwRI yes 5 +Pyrazinamide pncA p.Thr160Pro pncA_p.Thr160Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 11 11 0 12 0 4397 16822 0.00272170560217736 0.00140711126319081 0.00474944049676375 1 0.999780735048249 1 1 0.735351530602948 1 1 0.715085847081845 1 1 0.715085847081845 1 Inf 9.59534969372383 Inf 3.06132665482014e-08 66 1830 True False Inf 10.6239097645824 Inf 0.00249546279491833 0.00124636378089373 0.00446067538663459 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 10 10 0 11 0 3775 16046 0.00290544109878499 0.00145125037710396 0.0051926765025673 1 0.999770132403032 1 1 0.715085847081845 1 1 0.691502892181239 1 1 0.691502892181239 1 Inf 9.52040629218731 Inf 6.35375804424851e-08 67 1762 True False 0 0 0 0 0 0 0 Inf 10.6608738336509 Inf 0.00264200792602377 0.00126764994117653 0.00485336205963055 1 0.999770132403032 1 43 Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Thr167Ile pncA_p.Thr167Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 2 3 2 3 4407 16819 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.999821662109142 0.999478910338162 0.999963220929399 0.4 0.0527449505263169 0.853367200365326 0.4 0.0527449505263169 0.853367200365326 0.4 0.0527449505263169 0.853367200365326 2.5442856062325 0.212429984141661 22.2163543346012 0.278486861777475 482 1830 False False 2.5442856062325 0.212429984141661 22.2163543346012 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 1 2 3785 16044 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999875358344758 0.999549824781286 0.999984904960856 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 2.11941875825627 0.0359146288488272 40.7195918479678 0.470354459331036 493.5 1762 False False 0 0 0 0 0 0 0 2.11941875825627 0.0359146288488272 40.7195918479678 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999875358344758 0.999549824781286 0.999984904960856 43 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Thr167Pro pncA_p.Thr167Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 3 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA p.Thr168_Val169del pncA_p.Thr168_Val169del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Pyrazinamide pncA p.Thr168Ile pncA_p.Thr168Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.23555131695149 1 1273 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 4) Not assoc w R - Interim WHO 4) Not assoc w R - interim 1 3 0 3 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 10.2590571436125 1 554.5 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 5 Not assoc w RI 4) Not assoc w R - Interim No change yes 1 +Pyrazinamide pncA p.Thr168Pro pncA_p.Thr168Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 6 0 6 0 4403 16822 0.00136085280108868 0.000499567554195151 0.00295963286153356 1 0.999780735048249 1 1 0.540741873560099 1 1 0.540741873560099 1 1 0.540741873560099 1 Inf 4.49627002862219 Inf 7.99920101998881e-05 128.5 1830 True False Inf 4.49627002862219 Inf 0.00136085280108868 0.000499567554195151 0.00295963286153356 1 0.999780735048249 1 1) Assoc w R 2) Assoc w R - Interim WHO 2) Assoc w R - Interim 1 4 4 0 4 0 3782 16046 0.00105652403592181 0.000287939890647285 0.00270289202199999 1 0.999770132403032 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 2.79918348098377 Inf 0.0013264757267559 157.5 1762 True False 0 0 0 0 0 0 0 Inf 2.79918348098377 Inf 0.00105652403592181 0.000287939890647285 0.00270289202199999 1 0.999770132403032 1 3 Assoc w RI Interim based on WHO dataset 2) Assoc w R - Interim No change yes Interim on WHO 1 +Pyrazinamide pncA p.Thr177fs pncA_p.Thr177fs 1 frameshift (see "Genomic_coordinates" sheet) 1 3 3 0 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 1.57702975056642 Inf 0.00895106588186537 214 1830 False False Inf 1.57702975056642 Inf 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 2 2 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.796077158748321 Inf 0.0364363919492442 248 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 9 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Thr177Pro pncA_p.Thr177Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 8 1 8 1 4401 16821 0.00181447040145157 0.000783674794110066 0.0035720830153558 0.99994055403638 0.999668833292177 0.99999849495964 0.888888888888888 0.517503485082663 0.9971908632534 0.888888888888888 0.517503485082663 0.9971908632534 0.888888888888888 0.517503485082663 0.9971908632534 30.5766871165644 4.09674326327108 1347.13599331235 2.52655228636597e-05 121 1830 True False 30.5766871165644 4.09674326327108 1347.13599331235 0.00181447040145157 0.000783674794110066 0.0035720830153558 0.99994055403638 0.999668833292177 0.99999849495964 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 9 8 1 8 1 3778 16045 0.00211304807184363 0.00091269178353604 0.00415927925423806 0.999937679172379 0.999652820032955 0.999998422174497 0.888888888888888 0.517503485082663 0.9971908632534 0.888888888888888 0.517503485082663 0.9971908632534 0.888888888888888 0.517503485082663 0.9971908632534 33.9756484912652 4.55158722211531 1495.52925354629 1.3108272360446e-05 107.5 1762 True False 0 0 0 0 0 0 0 33.9756484912652 4.55158722211531 1495.52925354629 0.00211304807184363 0.00091269178353604 0.00415927925423806 0.999937679172379 0.999652820032955 0.999998422174497 56 Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Thr22fs pncA_p.Thr22fs 1 frameshift (see "Genomic_coordinates" sheet) 1 6 2 4 2 4 4407 16818 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.999762216145523 0.999391291831884 0.999935208223951 0.333333333333333 0.0432718682927417 0.777221904496487 0.333333333333333 0.0432718682927417 0.777221904496487 0.333333333333333 0.0432718682927417 0.777221904496487 1.90810074880871 0.172533114815209 13.318658680033 0.610860372757383 567 1830 False False 1.90810074880871 0.172533114815209 13.318658680033 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.999762216145523 0.999391291831884 0.999935208223951 3) Uncertain significance 2) Assoc w R - Interim WHO 2) Assoc w R - Interim 1 2 2 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.796077158748321 Inf 0.0364363919492442 248 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 9 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Thr47Ala pncA_p.Thr47Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 28 17 11 17 11 4392 16811 0.00385574960308459 0.00224767150840848 0.00616627368860949 0.99934609440019 0.998830284178405 0.999673528922672 0.607142857142857 0.405768206487563 0.784957170839039 0.607142857142857 0.405768206487563 0.784957170839039 0.607142857142857 0.405768206487563 0.784957170839039 5.91544543798642 2.61113828625998 13.9812880576092 4.80395200243901e-06 107 1830 True False 5.91544543798642 2.61113828625998 13.9812880576092 0.00385574960308459 0.00224767150840848 0.00616627368860949 0.99934609440019 0.998830284178405 0.999673528922672 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 27 17 10 17 10 3769 16036 0.00449022715266772 0.00261783253916465 0.00717958501762183 0.999376791723794 0.998854197426924 0.999701108243012 0.629629629629629 0.423679572504296 0.805992841284865 0.629629629629629 0.423679572504296 0.805992841284865 0.629629629629629 0.423679572504296 0.805992841284865 7.23300610241443 3.12440687024636 17.6799159193124 6.76463960755262e-07 86 1762 True False 0 0 0 0 0 0 0 7.23300610241443 3.12440687024636 17.6799159193124 0.00449022715266772 0.00261783253916465 0.00717958501762183 0.999376791723794 0.998854197426924 0.999701108243012 18 Not assoc w R Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Thr47Asn pncA_p.Thr47Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Thr47Ile pncA_p.Thr47Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.23555131695149 1 1273 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 2 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Thr47Pro pncA_p.Thr47Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 5 0 5 0 4404 16822 0.00113404400090723 0.000368320285107068 0.00264447958048867 1 0.999780735048249 1 1 0.478176249895018 1 1 0.478176249895018 1 1 0.478176249895018 1 Inf 3.49836879238979 Inf 0.000385538239896191 148 1830 True False Inf 3.49836879238979 Inf 0.00113404400090723 0.000368320285107068 0.00264447958048867 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 5 5 0 5 0 3781 16046 0.00132065504490227 0.000428947757354115 0.0030792549559865 1 0.999770132403032 1 1 0.478176249895018 1 1 0.478176249895018 1 1 0.478176249895018 1 Inf 3.88652681138742 Inf 0.000253012467147004 128 1762 True False 0 0 0 0 0 0 0 Inf 3.88652681138742 Inf 0.00132065504490227 0.000428947757354115 0.0030792549559865 1 0.999770132403032 1 10 Assoc w RI 1) Assoc w R UP from AwRI to AwR yes 4 +Pyrazinamide pncA p.Thr61fs pncA_p.Thr61fs 1 frameshift (see "Genomic_coordinates" sheet) 1 5 5 0 5 0 4404 16822 0.00113404400090723 0.000368320285107068 0.00264447958048867 1 0.999780735048249 1 1 0.478176249895018 1 1 0.478176249895018 1 1 0.478176249895018 1 Inf 3.49836879238979 Inf 0.000385538239896191 148 1830 True False Inf 3.49836879238979 Inf 0.00113404400090723 0.000368320285107068 0.00264447958048867 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 5 5 0 5 0 3781 16046 0.00132065504490227 0.000428947757354115 0.0030792549559865 1 0.999770132403032 1 1 0.478176249895018 1 1 0.478176249895018 1 1 0.478176249895018 1 Inf 3.88652681138742 Inf 0.000253012467147004 128 1762 True False 0 0 0 0 0 0 0 Inf 3.88652681138742 Inf 0.00132065504490227 0.000428947757354115 0.0030792549559865 1 0.999770132403032 1 6 1) Assoc w R UP from AwRI to AwR yes 4 +Pyrazinamide pncA p.Thr61Pro pncA_p.Thr61Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 3 2 4 2 4405 16820 0.000907235200725788 0.000247244623732042 0.00232123869101376 0.999881108072762 0.999570588169705 0.999985601311719 0.666666666666666 0.222778095503512 0.956728131707258 0.6 0.146632799634673 0.947255049473683 0.6 0.146632799634673 0.947255049473683 5.72758229284903 0.655826527842064 68.6907911007346 0.0639258618363032 292 1830 False False 7.63677639046538 1.09391175338604 84.6254023086715 0.000680580762250453 0.000140374111950171 0.0019876450342228 0.999881108072762 0.999570588169705 0.999985601311719 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 5 3 2 4 2 3782 16044 0.00105652403592181 0.000287939890647285 0.00270289202199999 0.999875358344758 0.999549824781286 0.999984904960856 0.666666666666666 0.222778095503512 0.956728131707258 0.6 0.146632799634673 0.947255049473683 0.6 0.146632799634673 0.947255049473683 6.36329984135378 0.728585524740908 76.0779632349286 0.0511203924231255 271 1762 False False 0 0 0 0 0 0 0 8.4843997884717 1.21526196730161 93.8406264671703 0.000792602377807133 0.000163483500741026 0.00231455637111671 0.999875358344758 0.999549824781286 0.999984904960856 11 2) Assoc w R - Interim UP from Uncertain to AwRI yes 4 +Pyrazinamide pncA p.Thr76Ala pncA_p.Thr76Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Thr76fs pncA_p.Thr76fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.716637886286628 Inf 0.0431182613129385 265.5 1830 False False Inf 0.716637886286628 Inf 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 2 2 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.796077158748321 Inf 0.0364363919492442 248 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 4 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Thr76Ile pncA_p.Thr76Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 7 1 8 2 4401 16820 0.00181447040145157 0.000783674794110066 0.0035720830153558 0.999881108072762 0.999570588169705 0.999985601311719 0.8 0.443904537692358 0.974789273673166 0.875 0.473490329124793 0.996840276468748 0.777777777777777 0.399906426283687 0.971855026522101 26.753010679391 3.43489848763797 1198.07051226222 0.000108561439251826 136 1830 True False 15.2874346739377 3.04876073502229 147.714411457989 0.00158802177858439 0.000638697975897407 0.00326917752821328 0.999881108072762 0.999570588169705 0.999985601311719 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 6 6 0 7 1 3779 16045 0.00184891706286318 0.000743673531480306 0.00380574231364529 0.999937679172379 0.999652820032955 0.999998422174497 0.875 0.473490329124793 0.996840276468748 1 0.540741873560099 1 0.857142857142857 0.421276802956804 0.996389703138099 Inf 4.99567327105958 Inf 4.82020615493841e-05 110 1762 True False 0 0 0 0 0 0 0 29.7208256152421 3.81564410496199 1329.90635130009 0.00158520475561426 0.00058195737791826 0.00344710660170385 0.999937679172379 0.999652820032955 0.999998422174497 16 Assoc w RI 1) Assoc w R UP from AwRI to AwR yes 4 +Pyrazinamide pncA p.Thr76Pro pncA_p.Thr76Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 55 52 3 52 3 4357 16819 0.0117940576094352 0.00882056549672099 0.0154378932348655 0.999821662109142 0.999478910338162 0.999963220929399 0.945454545454545 0.8487650452334 0.988606993727291 0.945454545454545 0.8487650452334 0.988606993727291 0.945454545454545 0.8487650452334 0.988606993727291 66.9105653737281 21.6462448720932 332.641805923271 3.34508148614913e-32 13 1830 True False 66.9105653737281 21.6462448720932 332.641805923271 0.0117940576094352 0.00882056549672099 0.0154378932348655 0.999821662109142 0.999478910338162 0.999963220929399 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 50 47 3 47 3 3739 16043 0.0124141574220813 0.00913532713452014 0.0164743503918647 0.999813037517138 0.999453714469566 0.999961442181588 0.94 0.834518053396227 0.987451412164666 0.94 0.834518053396227 0.987451412164666 0.94 0.834518053396227 0.987451412164666 67.2212712846572 21.6169308932718 335.360796219566 1.3277399454764e-30 11 1762 True False 0 0 0 0 0 0 0 67.2212712846572 21.6169308932718 335.360796219566 0.0124141574220813 0.00913532713452014 0.0164743503918647 0.999813037517138 0.999453714469566 0.999961442181588 111 Assoc w R Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Thr87fs pncA_p.Thr87fs 1 frameshift (see "Genomic_coordinates" sheet) 1 3 3 0 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 1.57702975056642 Inf 0.00895106588186537 214 1830 False False Inf 1.57702975056642 Inf 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 3 3 0 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 1.75196919627044 Inf 0.00695286470680484 189.5 1762 False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 NA 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Thr87Met pncA_p.Thr87Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 17 0 17 0 17 4409 16805 0 0 0.000836320411980403 0.998989418618475 0.998382452772912 0.999411192380357 0 0 0.195064322969093 0 0 0.195064322969093 0 0 0.195064322969093 0 0 0.92412091928757 0.0327895874109369 236 1830 False False 0 0 0.92412091928757 0 0 0.000836320411980403 0.998989418618475 0.998382452772912 0.999411192380357 3) Uncertain significance 4) Not assoc w R - Interim WHO 4) Not assoc w R - interim 1 17 0 17 0 17 3786 16029 0 0 0.000973872929872615 0.99894054593045 0.998304251550396 0.999382711664247 0 0 0.195064322969093 0 0 0.195064322969093 0 0 0.195064322969093 0 0 1.02659962523702 0.0570010130412879 274 1762 False False 0 0 0 0 0 0 0 0 0 1.02659962523702 0 0 0.000973872929872615 0.99894054593045 0.998304251550396 0.999382711664247 3 Not assoc w RI 4) Not assoc w R - Interim No change yes 1 +Pyrazinamide pncA p.Trp119Arg pncA_p.Trp119Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 5 0 5 0 4404 16822 0.00113404400090723 0.000368320285107068 0.00264447958048867 1 0.999780735048249 1 1 0.478176249895018 1 1 0.478176249895018 1 1 0.478176249895018 1 Inf 3.49836879238979 Inf 0.000385538239896191 148 1830 True False Inf 3.49836879238979 Inf 0.00113404400090723 0.000368320285107068 0.00264447958048867 1 0.999780735048249 1 1) Assoc w R 2) Assoc w R - Interim WHO 2) Assoc w R - Interim 1 4 4 0 4 0 3782 16046 0.00105652403592181 0.000287939890647285 0.00270289202199999 1 0.999770132403032 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 2.79918348098377 Inf 0.0013264757267559 157.5 1762 True False 0 0 0 0 0 0 0 Inf 2.79918348098377 Inf 0.00105652403592181 0.000287939890647285 0.00270289202199999 1 0.999770132403032 1 19 Assoc w RI Interim based on WHO dataset 2) Assoc w R - Interim No change yes Interim on WHO 1 +Pyrazinamide pncA p.Trp119Cys pncA_p.Trp119Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 3 0 5 1 4404 16821 0.00113404400090723 0.000368320285107068 0.00264447958048867 0.99994055403638 0.999668833292177 0.99999849495964 0.833333333333333 0.358765421002325 0.99578925548551 1 0.292401773821286 1 0.75 0.194120449683243 0.99369053679029 Inf 1.5776518567379 Inf 0.00894267808174931 202 1830 False False 19.0974114441416 2.13580486483461 898.821488982459 0.00068073519400953 0.00014040596947681 0.001988095759058 0.99994055403638 0.999668833292177 0.99999849495964 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 3 3 0 5 0 3781 16046 0.00132065504490227 0.000428947757354115 0.0030792549559865 1 0.999770132403032 1 1 0.478176249895018 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 1.75289725317766 Inf 0.0069439495408725 178 1762 False False 0 0 0 0 0 0 0 Inf 3.88652681138742 Inf 0.000792811839323467 0.000163526712515238 0.00231516757417407 1 0.999770132403032 1 8 Assoc w R 2) Assoc w R - Interim DOWN from AwR to AwRI yes 3 +Pyrazinamide pncA p.Trp119fs pncA_p.Trp119fs 1 frameshift (see "Genomic_coordinates" sheet) 1 8 8 0 8 0 4401 16822 0.00181447040145157 0.000783674794110066 0.0035720830153558 1 0.999780735048249 1 1 0.63058335244718 1 1 0.63058335244718 1 1 0.63058335244718 1 Inf 6.5206569685433 Inf 3.44167929021015e-06 103.5 1830 True False Inf 6.5206569685433 Inf 0.00181447040145157 0.000783674794110066 0.0035720830153558 1 0.999780735048249 1 1) Assoc w R 2) Assoc w R - Interim WHO 2) Assoc w R - Interim 1 2 2 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.796077158748321 Inf 0.0364363919492442 248 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 11 Interim based on WHO dataset 2) Assoc w R - Interim No change no Interim on WHO 1 +Pyrazinamide pncA p.Trp119Gly pncA_p.Trp119Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 5 0 5 0 4404 16822 0.00113404400090723 0.000368320285107068 0.00264447958048867 1 0.999780735048249 1 1 0.478176249895018 1 1 0.478176249895018 1 1 0.478176249895018 1 Inf 3.49836879238979 Inf 0.000385538239896191 148 1830 True False Inf 3.49836879238979 Inf 0.00113404400090723 0.000368320285107068 0.00264447958048867 1 0.999780735048249 1 1) Assoc w R 2) Assoc w R - Interim WHO 2) Assoc w R - Interim 1 3 3 0 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 1.75196919627044 Inf 0.00695286470680484 189.5 1762 False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 2 Assoc w RI Interim based on WHO dataset 2) Assoc w R - Interim No change yes Interim on WHO 1 +Pyrazinamide pncA p.Trp119Leu pncA_p.Trp119Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 3 0 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 1.57702975056642 Inf 0.00895106588186537 214 1830 False False Inf 1.57702975056642 Inf 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 3 3 0 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 1.75196919627044 Inf 0.00695286470680484 189.5 1762 False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 9 2) Assoc w R - Interim New AwRI yes 5 +Pyrazinamide pncA p.Trp119* pncA_p.Trp119* 1 stop_gained (see "Genomic_coordinates" sheet) 1 6 6 0 6 0 4403 16822 0.00136085280108868 0.000499567554195151 0.00295963286153356 1 0.999780735048249 1 1 0.540741873560099 1 1 0.540741873560099 1 1 0.540741873560099 1 Inf 4.49627002862219 Inf 7.99920101998881e-05 128.5 1830 True False Inf 4.49627002862219 Inf 0.00136085280108868 0.000499567554195151 0.00295963286153356 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 5 5 0 5 0 3781 16046 0.00132065504490227 0.000428947757354115 0.0030792549559865 1 0.999770132403032 1 1 0.478176249895018 1 1 0.478176249895018 1 1 0.478176249895018 1 Inf 3.88652681138742 Inf 0.000253012467147004 128 1762 True False 0 0 0 0 0 0 0 Inf 3.88652681138742 Inf 0.00132065504490227 0.000428947757354115 0.0030792549559865 1 0.999770132403032 1 6 Assoc w R Assoc w RI 1) Assoc w R UP from AwRI to AwR yes 4 +Pyrazinamide pncA p.Trp68Arg pncA_p.Trp68Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 19 18 1 18 1 4391 16821 0.00408255840326604 0.00242132299966848 0.00644455638933336 0.99994055403638 0.999668833292177 0.99999849495964 0.947368421052631 0.739719345804785 0.99866837119582 0.947368421052631 0.739719345804785 0.99866837119582 0.947368421052631 0.739719345804785 0.99866837119582 68.9542245502163 10.879469270587 2828.64450531077 7.66740630544103e-12 48 1830 True False 68.9542245502163 10.879469270587 2828.64450531077 0.00408255840326604 0.00242132299966848 0.00644455638933336 0.99994055403638 0.999668833292177 0.99999849495964 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 17 16 1 16 1 3770 16045 0.00422609614368726 0.00241744983392875 0.00685386626076289 0.999937679172379 0.999652820032955 0.999998422174497 0.941176470588235 0.713110603332779 0.998511825608733 0.941176470588235 0.713110603332779 0.998511825608733 0.941176470588235 0.713110603332779 0.998511825608733 68.0954907161803 10.5709316202535 2811.48875084136 4.23282943989475e-11 45 1762 True False 0 0 0 0 0 0 0 68.0954907161803 10.5709316202535 2811.48875084136 0.00422609614368726 0.00241744983392875 0.00685386626076289 0.999937679172379 0.999652820032955 0.999998422174497 47 Assoc w R Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Trp68Cys pncA_p.Trp68Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 20 20 0 20 0 4389 16822 0.00453617600362894 0.00277294929564062 0.00699710319549207 1 0.999780735048249 1 1 0.831566529016914 1 1 0.831566529016914 1 1 0.831566529016914 1 Inf 18.9082936232782 Inf 2.15049156185091e-14 40.5 1830 True False Inf 18.9082936232782 Inf 0.00453617600362894 0.00277294929564062 0.00699710319549207 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 19 19 0 19 0 3767 16046 0.00501848917062863 0.00302408120608821 0.00782594556552751 1 0.999770132403032 1 1 0.823533088193034 1 1 0.823533088193034 1 1 0.823533088193034 1 Inf 19.8611544368769 Inf 2.08720983239118e-14 33 1762 True False 0 0 0 0 0 0 0 Inf 19.8611544368769 Inf 0.00501848917062863 0.00302408120608821 0.00782594556552751 1 0.999770132403032 1 15 Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Trp68Gly pncA_p.Trp68Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 34 32 2 32 2 4377 16820 0.0072578816058063 0.00496952882236571 0.0102306442081507 0.999881108072762 0.999570588169705 0.999985601311719 0.941176470588235 0.803226790664424 0.99279508256095 0.941176470588235 0.803226790664424 0.99279508256095 0.941176470588235 0.803226790664424 0.99279508256095 61.4850354123829 15.6728013910892 528.894166589364 4.69824076107731e-20 28 1830 True False 61.4850354123829 15.6728013910892 528.894166589364 0.0072578816058063 0.00496952882236571 0.0102306442081507 0.999881108072762 0.999570588169705 0.999985601311719 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 33 31 2 31 2 3755 16044 0.00818806127839408 0.00556997590891501 0.0116023265173252 0.999875358344758 0.999549824781286 0.999984904960856 0.939393939393939 0.797735687473645 0.99257416225774 0.939393939393939 0.797735687473645 0.99257416225774 0.939393939393939 0.797735687473645 0.99257416225774 66.2268974700399 16.8370444322908 570.40722977222 1.61539843883625e-20 22 1762 True False 0 0 0 0 0 0 0 66.2268974700399 16.8370444322908 570.40722977222 0.00818806127839408 0.00556997590891501 0.0116023265173252 0.999875358344758 0.999549824781286 0.999984904960856 138 Assoc w R Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Trp68Leu pncA_p.Trp68Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.716637886286628 Inf 0.0431182613129385 265.5 1830 False False Inf 0.716637886286628 Inf 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 4 2) Assoc w R - Interim UP from Uncertain to AwRI yes 4 +Pyrazinamide pncA p.Trp68Ser pncA_p.Trp68Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 4408 16821 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 3.81601633393829 0.0486026416232846 298.829108180248 0.372217803874758 506.5 1830 False False 3.81601633393829 0.0486026416232846 298.829108180248 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 3785 16045 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 4.23910171730515 0.0539892730999128 331.863925136224 0.345370788365398 466.5 1762 False False 0 0 0 0 0 0 0 4.23910171730515 0.0539892730999128 331.863925136224 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 3 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Trp68* pncA_p.Trp68* 1 stop_gained (see "Genomic_coordinates" sheet) 1 5 5 0 5 0 4404 16822 0.00113404400090723 0.000368320285107068 0.00264447958048867 1 0.999780735048249 1 1 0.478176249895018 1 1 0.478176249895018 1 1 0.478176249895018 1 Inf 3.49836879238979 Inf 0.000385538239896191 148 1830 True False Inf 3.49836879238979 Inf 0.00113404400090723 0.000368320285107068 0.00264447958048867 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 5 5 0 5 0 3781 16046 0.00132065504490227 0.000428947757354115 0.0030792549559865 1 0.999770132403032 1 1 0.478176249895018 1 1 0.478176249895018 1 1 0.478176249895018 1 Inf 3.88652681138742 Inf 0.000253012467147004 128 1762 True False 0 0 0 0 0 0 0 Inf 3.88652681138742 Inf 0.00132065504490227 0.000428947757354115 0.0030792549559865 1 0.999770132403032 1 9 Assoc w R Assoc w RI 1) Assoc w R UP from AwRI to AwR yes 4 +Pyrazinamide pncA p.Tyr103Asp pncA_p.Tyr103Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 2 1 2 1 4407 16821 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.99994055403638 0.999668833292177 0.99999849495964 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 7.63376446562287 0.397281353658273 449.052313013199 0.111452652175084 308.5 1830 False False 7.63376446562287 0.397281353658273 449.052313013199 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.99994055403638 0.999668833292177 0.99999849495964 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 3 2 1 2 1 3784 16045 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999937679172379 0.999652820032955 0.999998422174497 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 8.48044397463002 0.441282441622781 498.676520130596 0.0954034464341229 286.5 1762 False False 0 0 0 0 0 0 0 8.48044397463002 0.441282441622781 498.676520130596 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999937679172379 0.999652820032955 0.999998422174497 5 Assoc w RI 2) Assoc w R - Interim No change yes 1 +Pyrazinamide pncA p.Tyr103Cys pncA_p.Tyr103Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 13 9 4 9 4 4400 16818 0.00204127920163302 0.000933814369660709 0.00387143149170671 0.999762216145523 0.999391291831884 0.999935208223951 0.692307692307692 0.385738338249294 0.909079605427903 0.692307692307692 0.385738338249294 0.909079605427903 0.692307692307692 0.385738338249294 0.909079605427903 8.60011363636363 2.39873444903542 38.2294429018792 0.000224094147128743 141 1830 True False 8.60011363636363 2.39873444903542 38.2294429018792 0.00204127920163302 0.000933814369660709 0.00387143149170671 0.999762216145523 0.999391291831884 0.999935208223951 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 11 8 3 8 3 3778 16043 0.00211304807184363 0.00091269178353604 0.00415927925423806 0.999813037517138 0.999453714469566 0.999961442181588 0.727272727272727 0.390257440427578 0.939782265827093 0.727272727272727 0.390257440427578 0.939782265827093 0.727272727272727 0.390257440427578 0.939782265827093 11.3238044820892 2.71592126399482 66.4138737417137 0.000166050946264097 120 1762 True False 0 0 0 0 0 0 0 11.3238044820892 2.71592126399482 66.4138737417137 0.00211304807184363 0.00091269178353604 0.00415927925423806 0.999813037517138 0.999453714469566 0.999961442181588 18 Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Tyr103fs pncA_p.Tyr103fs 1 frameshift (see "Genomic_coordinates" sheet) 1 4 4 0 4 0 4405 16822 0.000907235200725788 0.000247244623732042 0.00232123869101376 1 0.999780735048249 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 2.51959224712996 Inf 0.00185784794966548 174 1830 True False Inf 2.51959224712996 Inf 0.000907235200725788 0.000247244623732042 0.00232123869101376 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 4 4 0 4 0 3782 16046 0.00105652403592181 0.000287939890647285 0.00270289202199999 1 0.999770132403032 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 2.79918348098377 Inf 0.0013264757267559 157.5 1762 True False 0 0 0 0 0 0 0 Inf 2.79918348098377 Inf 0.00105652403592181 0.000287939890647285 0.00270289202199999 1 0.999770132403032 1 5 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Tyr103His pncA_p.Tyr103His 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 7 0 7 0 4402 16822 0.00158766160127012 0.000638553061192671 0.00326843667440656 1 0.999780735048249 1 1 0.590383602774996 1 1 0.590383602774996 1 1 0.590383602774996 1 Inf 5.50478416804174 Inf 1.65938667095456e-05 115.5 1830 True False Inf 5.50478416804174 Inf 0.00158766160127012 0.000638553061192671 0.00326843667440656 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 7 7 0 7 0 3779 16046 0.00184891706286318 0.000743673531480306 0.00380574231364529 1 0.999770132403032 1 1 0.590383602774996 1 1 0.590383602774996 1 1 0.590383602774996 1 Inf 6.11594331475081 Inf 9.19916249305378e-06 102.5 1762 True False 0 0 0 0 0 0 0 Inf 6.11594331475081 Inf 0.00184891706286318 0.000743673531480306 0.00380574231364529 1 0.999770132403032 1 25 Assoc w R Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Tyr103Ser pncA_p.Tyr103Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 Assoc w RI 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Pyrazinamide pncA p.Tyr103* pncA_p.Tyr103* 1 stop_gained (see "Genomic_coordinates" sheet) 1 26 26 0 26 0 4383 16822 0.00589702880471762 0.00385564427656477 0.00862865525716627 1 0.999780735048249 1 1 0.867725395502245 1 1 0.867725395502245 1 1 0.867725395502245 1 Inf 25.171269852009 Inf 1.68339733269082e-18 32 1830 True False Inf 25.171269852009 Inf 0.00589702880471762 0.00385564427656477 0.00862865525716627 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 20 20 0 20 0 3766 16046 0.00528262017960908 0.00322965810863289 0.00814684323786685 1 0.999770132403032 1 1 0.831566529016914 1 1 0.831566529016914 1 1 0.831566529016914 1 Inf 21.0169304362191 Inf 3.96836392197933e-15 29 1762 True False 0 0 0 0 0 0 0 Inf 21.0169304362191 Inf 0.00528262017960908 0.00322965810863289 0.00814684323786685 1 0.999770132403032 1 89 Assoc w R Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Tyr34Asp pncA_p.Tyr34Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 18 18 0 18 0 4391 16822 0.00408255840326604 0.00242132299966848 0.00644455638933336 1 0.999780735048249 1 1 0.814698031862147 1 1 0.814698031862147 1 1 0.814698031862147 1 Inf 16.8323383001074 Inf 5.01988185381643e-13 44 1830 True False Inf 16.8323383001074 Inf 0.00408255840326604 0.00242132299966848 0.00644455638933336 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 13 13 0 13 0 3773 16046 0.0034337031167459 0.00182953006918454 0.00586457926930979 1 0.999770132403032 1 1 0.752947361999529 1 1 0.752947361999529 1 1 0.752947361999529 1 Inf 12.9516379657707 Inf 4.39880194628741e-10 51 1762 True False 0 0 0 0 0 0 0 Inf 12.9516379657707 Inf 0.0034337031167459 0.00182953006918454 0.00586457926930979 1 0.999770132403032 1 16 Assoc w R Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Tyr34Ser pncA_p.Tyr34Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.716637886286628 Inf 0.0431182613129385 265.5 1830 False False Inf 0.716637886286628 Inf 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 2 2 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.796077158748321 Inf 0.0364363919492442 248 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 4 2) Assoc w R - Interim New AwRI yes 5 +Pyrazinamide pncA p.Tyr34* pncA_p.Tyr34* 1 stop_gained (see "Genomic_coordinates" sheet) 1 4 4 0 4 0 4405 16822 0.000907235200725788 0.000247244623732042 0.00232123869101376 1 0.999780735048249 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 2.51959224712996 Inf 0.00185784794966548 174 1830 True False Inf 2.51959224712996 Inf 0.000907235200725788 0.000247244623732042 0.00232123869101376 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 4 4 0 4 0 3782 16046 0.00105652403592181 0.000287939890647285 0.00270289202199999 1 0.999770132403032 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 2.79918348098377 Inf 0.0013264757267559 157.5 1762 True False 0 0 0 0 0 0 0 Inf 2.79918348098377 Inf 0.00105652403592181 0.000287939890647285 0.00270289202199999 1 0.999770132403032 1 37 Assoc w R Assoc w RI 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Tyr41Cys pncA_p.Tyr41Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Tyr41* pncA_p.Tyr41* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.097852308370781 Inf 0.207630711257654 334.5 1830 False False Inf 0.716637886286628 Inf 0.000226860254083484 5.74358785768897e-06 0.0012633291757201 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 14 Assoc w R Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Tyr64Asp pncA_p.Tyr64Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 3 2 3 2 4406 16820 0.000680426400544341 0.000140342268876931 0.00198719451371054 0.999881108072762 0.999570588169705 0.999985601311719 0.6 0.146632799634673 0.947255049473683 0.6 0.146632799634673 0.947255049473683 0.6 0.146632799634673 0.947255049473683 5.72628234226055 0.655677739135472 68.675028521871 0.0639561690130486 294 1830 False False 5.72628234226055 0.655677739135472 68.675028521871 0.000680426400544341 0.000140342268876931 0.00198719451371054 0.999881108072762 0.999570588169705 0.999985601311719 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 5 3 2 3 2 3783 16044 0.000792393026941363 0.000163440311798119 0.00231394549068866 0.999875358344758 0.999549824781286 0.999984904960856 0.6 0.146632799634673 0.947255049473683 0.6 0.146632799634673 0.947255049473683 0.6 0.146632799634673 0.947255049473683 6.36161776367961 0.728392675067714 76.0575760881352 0.051149585969592 272 1762 False False 0 0 0 0 0 0 0 6.36161776367961 0.728392675067714 76.0575760881352 0.000792393026941363 0.000163440311798119 0.00231394549068866 0.999875358344758 0.999549824781286 0.999984904960856 7 Assoc w RI 2) Assoc w R - Interim No change yes 1 +Pyrazinamide pncA p.Tyr64fs pncA_p.Tyr64fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Tyr64* pncA_p.Tyr64* 1 stop_gained (see "Genomic_coordinates" sheet) 1 8 7 1 7 1 4402 16821 0.00158766160127012 0.000638553061192671 0.00326843667440656 0.99994055403638 0.999668833292177 0.99999849495964 0.875 0.473490329124793 0.996840276468748 0.875 0.473490329124793 0.996840276468748 0.875 0.473490329124793 0.996840276468748 26.7485233984552 3.43432279452703 1197.87100642049 0.000108659178644894 138 1830 True False 26.7485233984552 3.43432279452703 1197.87100642049 0.00158766160127012 0.000638553061192671 0.00326843667440656 0.99994055403638 0.999668833292177 0.99999849495964 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 6 5 1 5 1 3781 16045 0.00132065504490227 0.000428947757354115 0.0030792549559865 0.999937679172379 0.999652820032955 0.999998422174497 0.833333333333333 0.358765421002325 0.99578925548551 0.833333333333333 0.358765421002325 0.99578925548551 0.833333333333333 0.358765421002325 0.99578925548551 21.2179317640835 2.3726027647035 998.008782436883 0.00127682798332212 142 1762 True False 0 0 0 0 0 0 0 21.2179317640835 2.3726027647035 998.008782436883 0.00132065504490227 0.000428947757354115 0.0030792549559865 0.999937679172379 0.999652820032955 0.999998422174497 10 Assoc w R Assoc w RI 1) Assoc w R UP from AwRI to AwR yes 4 +Pyrazinamide pncA p.Tyr95Asp pncA_p.Tyr95Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 2 2 2 2 4407 16820 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.999881108072762 0.999570588169705 0.999985601311719 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 3.8166553210801 0.276553001924986 52.6392074577436 0.192674584671704 327.5 1830 False False 3.8166553210801 0.276553001924986 52.6392074577436 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.999881108072762 0.999570588169705 0.999985601311719 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 2 2 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.796077158748321 Inf 0.0364363919492442 248 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 2) Assoc w R - Interim UP from Uncertain to AwRI yes 4 +Pyrazinamide pncA p.Tyr95fs pncA_p.Tyr95fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.716637886286628 Inf 0.0431182613129385 265.5 1830 False False Inf 0.716637886286628 Inf 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Tyr95* pncA_p.Tyr95* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 6 Assoc w R Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Tyr99Cys pncA_p.Tyr99Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Tyr99fs pncA_p.Tyr99fs 1 frameshift (see "Genomic_coordinates" sheet) 1 6 6 0 6 0 4403 16822 0.00136085280108868 0.000499567554195151 0.00295963286153356 1 0.999780735048249 1 1 0.540741873560099 1 1 0.540741873560099 1 1 0.540741873560099 1 Inf 4.49627002862219 Inf 7.99920101998881e-05 128.5 1830 True False Inf 4.49627002862219 Inf 0.00136085280108868 0.000499567554195151 0.00295963286153356 1 0.999780735048249 1 1) Assoc w R 2) Assoc w R - Interim WHO 2) Assoc w R - Interim 1 3 3 0 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 1.75196919627044 Inf 0.00695286470680484 189.5 1762 False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 8 Interim based on WHO dataset 2) Assoc w R - Interim No change no Interim on WHO 1 +Pyrazinamide pncA p.Tyr99* pncA_p.Tyr99* 1 stop_gained (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.716637886286628 Inf 0.0431182613129385 265.5 1830 False False Inf 0.716637886286628 Inf 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 2 2 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.796077158748321 Inf 0.0364363919492442 248 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 9 Assoc w R Assoc w RI 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Val109Gly pncA_p.Val109Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 1 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Val125Asp pncA_p.Val125Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA p.Val125fs pncA_p.Val125fs 1 frameshift (see "Genomic_coordinates" sheet) 1 3 2 1 2 1 4407 16821 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.99994055403638 0.999668833292177 0.99999849495964 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 7.63376446562287 0.397281353658273 449.052313013199 0.111452652175084 308.5 1830 False False 7.63376446562287 0.397281353658273 449.052313013199 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.99994055403638 0.999668833292177 0.99999849495964 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 2 2 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.796077158748321 Inf 0.0364363919492442 248 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 3 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Val125Gly pncA_p.Val125Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 19 19 0 19 0 4390 16822 0.00430936720344749 0.0025964540708268 0.00672146538628393 1 0.999780735048249 1 1 0.823533088193034 1 1 0.823533088193034 1 1 0.823533088193034 1 Inf 17.8732226040779 Inf 1.03909400933898e-13 42 1830 True False Inf 17.8732226040779 Inf 0.00430936720344749 0.0025964540708268 0.00672146538628393 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 19 19 0 19 0 3767 16046 0.00501848917062863 0.00302408120608821 0.00782594556552751 1 0.999770132403032 1 1 0.823533088193034 1 1 0.823533088193034 1 1 0.823533088193034 1 Inf 19.8611544368769 Inf 2.08720983239118e-14 33 1762 True False 0 0 0 0 0 0 0 Inf 19.8611544368769 Inf 0.00501848917062863 0.00302408120608821 0.00782594556552751 1 0.999770132403032 1 4 Assoc w R Assoc w RI 1) Assoc w R UP from AwRI to AwR yes 4 +Pyrazinamide pncA p.Val125Ile pncA_p.Val125Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Val125Phe pncA_p.Val125Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 11 7 4 7 4 4402 16818 0.00158766160127012 0.000638553061192671 0.00326843667440656 0.999762216145523 0.999391291831884 0.999935208223951 0.636363636363636 0.307904715011677 0.890736556180901 0.636363636363636 0.307904715011677 0.890736556180901 0.636363636363636 0.307904715011677 0.890736556180901 6.68593820990458 1.69854767636033 31.1570661816584 0.00246964747952072 193 1830 True False 6.68593820990458 1.69854767636033 31.1570661816584 0.00158766160127012 0.000638553061192671 0.00326843667440656 0.999762216145523 0.999391291831884 0.999935208223951 1) Assoc w R 2) Assoc w R - Interim WHO 2) Assoc w R - Interim 1 8 5 3 5 3 3781 16043 0.00132065504490227 0.000428947757354115 0.0030792549559865 0.999813037517138 0.999453714469566 0.999961442181588 0.625 0.244863216366551 0.914766585862746 0.625 0.244863216366551 0.914766585862746 0.625 0.244863216366551 0.914766585862746 7.07176232037379 1.37501841621148 45.5380701298121 0.00845631333330319 203.5 1762 False False 0 0 0 0 0 0 0 7.07176232037379 1.37501841621148 45.5380701298121 0.00132065504490227 0.000428947757354115 0.0030792549559865 0.999813037517138 0.999453714469566 0.999961442181588 16 Assoc w R Interim based on WHO dataset 2) Assoc w R - Interim DOWN from AwR to AwRI yes Interim on WHO 3 +Pyrazinamide pncA p.Val128fs pncA_p.Val128fs 1 frameshift (see "Genomic_coordinates" sheet) 1 8 8 0 8 0 4401 16822 0.00181447040145157 0.000783674794110066 0.0035720830153558 1 0.999780735048249 1 1 0.63058335244718 1 1 0.63058335244718 1 1 0.63058335244718 1 Inf 6.5206569685433 Inf 3.44167929021015e-06 103.5 1830 True False Inf 6.5206569685433 Inf 0.00181447040145157 0.000783674794110066 0.0035720830153558 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 8 8 0 8 0 3778 16046 0.00211304807184363 0.00091269178353604 0.00415927925423806 1 0.999770132403032 1 1 0.63058335244718 1 1 0.63058335244718 1 1 0.63058335244718 1 Inf 7.24385478693174 Inf 1.75352509766709e-06 91 1762 True False 0 0 0 0 0 0 0 Inf 7.24385478693174 Inf 0.00211304807184363 0.00091269178353604 0.00415927925423806 1 0.999770132403032 1 4 1) Assoc w R UP from AwRI to AwR yes 4 +Pyrazinamide pncA p.Val128Gly pncA_p.Val128Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 14 14 0 14 0 4395 16822 0.00317532320254025 0.00173703251080297 0.00532191922970533 1 0.999780735048249 1 1 0.768364238349883 1 1 0.768364238349883 1 1 0.768364238349883 1 Inf 12.687987818897 Inf 2.72938067891301e-10 54 1830 True False Inf 12.687987818897 Inf 0.00317532320254025 0.00173703251080297 0.00532191922970533 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 14 14 0 14 0 3772 16046 0.00369783412572636 0.00202306972195899 0.00619656153938766 1 0.999770132403032 1 1 0.768364238349883 1 1 0.768364238349883 1 1 0.768364238349883 1 Inf 14.1050309606986 Inf 8.37412570934078e-11 49 1762 True False 0 0 0 0 0 0 0 Inf 14.1050309606986 Inf 0.00369783412572636 0.00202306972195899 0.00619656153938766 1 0.999770132403032 1 22 Assoc w R Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Val128Ile pncA_p.Val128Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Val130fs pncA_p.Val130fs 1 frameshift (see "Genomic_coordinates" sheet) 1 7 7 0 7 0 4402 16822 0.00158766160127012 0.000638553061192671 0.00326843667440656 1 0.999780735048249 1 1 0.590383602774996 1 1 0.590383602774996 1 1 0.590383602774996 1 Inf 5.50478416804174 Inf 1.65938667095456e-05 115.5 1830 True False Inf 5.50478416804174 Inf 0.00158766160127012 0.000638553061192671 0.00326843667440656 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 6 6 0 6 0 3780 16046 0.00158478605388272 0.000581803608073282 0.0034461969631646 1 0.999770132403032 1 1 0.540741873560099 1 1 0.540741873560099 1 1 0.540741873560099 1 Inf 4.99466385094306 Inf 4.82493639119799e-05 113.5 1762 True False 0 0 0 0 0 0 0 Inf 4.99466385094306 Inf 0.00158478605388272 0.000581803608073282 0.0034461969631646 1 0.999770132403032 1 30 1) Assoc w R UP from AwRI to AwR yes 4 +Pyrazinamide pncA p.Val130Gly pncA_p.Val130Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 3 0 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 1.57702975056642 Inf 0.00895106588186537 214 1830 False False Inf 1.57702975056642 Inf 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 3 3 0 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 1.75196919627044 Inf 0.00695286470680484 189.5 1762 False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 8 Assoc w R 2) Assoc w R - Interim DOWN from AwR to AwRI yes 3 +Pyrazinamide pncA p.Val130Met pncA_p.Val130Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.716637886286628 Inf 0.0431182613129385 265.5 1830 False False Inf 0.716637886286628 Inf 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 2) Assoc w R - Interim New AwRI yes 5 +Pyrazinamide pncA p.Val131fs pncA_p.Val131fs 1 frameshift (see "Genomic_coordinates" sheet) 1 53 53 0 54 0 4355 16822 0.0122476752097981 0.00921385751408697 0.0159506817359044 1 0.999780735048249 1 1 0.933968485755578 1 1 0.932765453693698 1 1 0.932765453693698 1 Inf 53.5371815120119 Inf 5.10926413702829e-37 7 1830 True False Inf 54.5648936351509 Inf 0.0120235934664246 0.00901911277759958 0.0156979846838304 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 48 48 0 48 0 3738 16046 0.0126782884310618 0.00936236245178074 0.0167747905688944 1 0.999770132403032 1 1 0.926027214652719 1 1 0.926027214652719 1 1 0.926027214652719 1 Inf 53.6804915868774 Inf 2.3651565626624e-35 7 1762 True False 0 0 0 0 0 0 0 Inf 53.6804915868774 Inf 0.0126782884310618 0.00936236245178074 0.0167747905688944 1 0.999770132403032 1 170 1) Assoc w R UP from AwRI to AwR yes 4 +Pyrazinamide pncA p.Val131Gly pncA_p.Val131Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 5 1 5 1 4404 16821 0.00113404400090723 0.000368320285107068 0.00264447958048867 0.99994055403638 0.999668833292177 0.99999849495964 0.833333333333333 0.358765421002325 0.99578925548551 0.833333333333333 0.358765421002325 0.99578925548551 0.833333333333333 0.358765421002325 0.99578925548551 19.0974114441416 2.13580486483461 898.821488982459 0.0019132693883777 189.5 1830 True False 19.0974114441416 2.13580486483461 898.821488982459 0.00113404400090723 0.000368320285107068 0.00264447958048867 0.99994055403638 0.999668833292177 0.99999849495964 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 5 Assoc w RI Evidence from ALL dataset only 2) Assoc w R - Interim No change yes ALL only 1 +Pyrazinamide pncA p.Val131Phe pncA_p.Val131Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 4 1 4 1 4405 16821 0.000907235200725788 0.000247244623732042 0.00232123869101376 0.99994055403638 0.999668833292177 0.99999849495964 0.8 0.28358206388191 0.994949236620532 0.8 0.28358206388191 0.994949236620532 0.8 0.28358206388191 0.994949236620532 15.2744608399545 1.5107888308703 749.051486258063 0.00774708678874264 197 1830 False False 15.2744608399545 1.5107888308703 749.051486258063 0.000907235200725788 0.000247244623732042 0.00232123869101376 0.99994055403638 0.999668833292177 0.99999849495964 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 5 4 1 4 1 3782 16045 0.00105652403592181 0.000287939890647285 0.00270289202199999 0.999937679172379 0.999652820032955 0.999998422174497 0.8 0.28358206388191 0.994949236620532 0.8 0.28358206388191 0.994949236620532 0.8 0.28358206388191 0.994949236620532 16.9698572184029 1.67834059794994 831.753865754 0.00562032876519148 175.5 1762 False False 0 0 0 0 0 0 0 16.9698572184029 1.67834059794994 831.753865754 0.00105652403592181 0.000287939890647285 0.00270289202199999 0.999937679172379 0.999652820032955 0.999998422174497 9 Assoc w RI 2) Assoc w R - Interim No change yes 1 +Pyrazinamide pncA p.Val139Ala pncA_p.Val139Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 62 57 5 59 5 4350 16817 0.0133817192107053 0.0102019701761145 0.0172278931544713 0.999702770181904 0.999306502227134 0.999903483469113 0.921875 0.827021670995792 0.974146159832032 0.919354838709677 0.821747406867766 0.973295383204164 0.919354838709677 0.821747406867766 0.973295383204164 44.0721379310344 17.8077225716408 140.897484409272 1.89293455225467e-33 9 1830 True False 45.6185287356321 18.4693503004365 145.583479591877 0.012933968686181 0.00981038161500907 0.0167253615735083 0.999702770181904 0.999306502227134 0.999903483469113 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 55 50 5 51 5 3735 16041 0.0134706814580031 0.0100458110916495 0.0176738345186089 0.999688395861897 0.99927297097682 0.999898815491092 0.910714285714285 0.803806559065217 0.970370158110457 0.909090909090909 0.800460384229499 0.969819132154186 0.909090909090909 0.800460384229499 0.969819132154186 42.9477911646586 17.2081239419194 138.034364563463 1.04395652449208e-30 10 1762 True False 0 0 0 0 0 0 0 43.8067469879518 17.5780292478876 140.65762932142 0.0132100396301188 0.0098202140678944 0.017379102116716 0.999688395861897 0.99927297097682 0.999898815491092 145 Assoc w R Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Val139Gly pncA_p.Val139Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 15 15 0 15 0 4394 16822 0.0034021320027217 0.00190535929953375 0.005605100858211 1 0.999780735048249 1 1 0.781980639089466 1 1 0.781980639089466 1 1 0.781980639089466 1 Inf 13.7221712262285 Inf 5.65378144121353e-11 50.5 1830 True False Inf 13.7221712262285 Inf 0.0034021320027217 0.00190535929953375 0.005605100858211 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 15 15 0 15 0 3771 16046 0.00396196513470681 0.002219125650155 0.0065262525797864 1 0.999770132403032 1 1 0.781980639089466 1 1 0.781980639089466 1 1 0.781980639089466 1 Inf 15.2504674111995 Inf 1.59386427367209e-11 43 1762 True False 0 0 0 0 0 0 0 Inf 15.2504674111995 Inf 0.00396196513470681 0.002219125650155 0.0065262525797864 1 0.999770132403032 1 41 Assoc w R Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Val139Leu pncA_p.Val139Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 2 1 2 1 4407 16821 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.99994055403638 0.999668833292177 0.99999849495964 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 7.63376446562287 0.397281353658273 449.052313013199 0.111452652175084 308.5 1830 False False 7.63376446562287 0.397281353658273 449.052313013199 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.99994055403638 0.999668833292177 0.99999849495964 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 3 2 1 2 1 3784 16045 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999937679172379 0.999652820032955 0.999998422174497 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 8.48044397463002 0.441282441622781 498.676520130596 0.0954034464341229 286.5 1762 False False 0 0 0 0 0 0 0 8.48044397463002 0.441282441622781 498.676520130596 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999937679172379 0.999652820032955 0.999998422174497 11 Assoc w R Assoc w RI 2) Assoc w R - Interim No change yes 1 +Pyrazinamide pncA p.Val139Met pncA_p.Val139Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 8 0 8 0 4401 16822 0.00181447040145157 0.000783674794110066 0.0035720830153558 1 0.999780735048249 1 1 0.63058335244718 1 1 0.63058335244718 1 1 0.63058335244718 1 Inf 6.5206569685433 Inf 3.44167929021015e-06 103.5 1830 True False Inf 6.5206569685433 Inf 0.00181447040145157 0.000783674794110066 0.0035720830153558 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 8 8 0 8 0 3778 16046 0.00211304807184363 0.00091269178353604 0.00415927925423806 1 0.999770132403032 1 1 0.63058335244718 1 1 0.63058335244718 1 1 0.63058335244718 1 Inf 7.24385478693174 Inf 1.75352509766709e-06 91 1762 True False 0 0 0 0 0 0 0 Inf 7.24385478693174 Inf 0.00211304807184363 0.00091269178353604 0.00415927925423806 1 0.999770132403032 1 60 1) Assoc w R UP from Uncertain to AwR yes 4 +Pyrazinamide pncA p.Val155Ala pncA_p.Val155Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 2 2 2 2 4407 16820 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.999881108072762 0.999570588169705 0.999985601311719 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 3.8166553210801 0.276553001924986 52.6392074577436 0.192674584671704 327.5 1830 False False 3.8166553210801 0.276553001924986 52.6392074577436 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.999881108072762 0.999570588169705 0.999985601311719 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 4 2 2 2 2 3784 16044 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999875358344758 0.999549824781286 0.999984904960856 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 4.2399577167019 0.307210542317908 58.5302826936734 0.166974861221294 305 1762 False False 0 0 0 0 0 0 0 4.2399577167019 0.307210542317908 58.5302826936734 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999875358344758 0.999549824781286 0.999984904960856 6 2) Assoc w R - Interim UP from Uncertain to AwRI yes 4 +Pyrazinamide pncA p.Val155dup pncA_p.Val155dup 1 inframe_insertion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Pyrazinamide pncA p.Val155fs pncA_p.Val155fs 1 frameshift (see "Genomic_coordinates" sheet) 1 5 5 0 5 0 4404 16822 0.00113404400090723 0.000368320285107068 0.00264447958048867 1 0.999780735048249 1 1 0.478176249895018 1 1 0.478176249895018 1 1 0.478176249895018 1 Inf 3.49836879238979 Inf 0.000385538239896191 148 1830 True False Inf 3.49836879238979 Inf 0.00113404400090723 0.000368320285107068 0.00264447958048867 1 0.999780735048249 1 1) Assoc w R 2) Assoc w R - Interim WHO 2) Assoc w R - Interim 1 4 4 0 4 0 3782 16046 0.00105652403592181 0.000287939890647285 0.00270289202199999 1 0.999770132403032 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 2.79918348098377 Inf 0.0013264757267559 157.5 1762 True False 0 0 0 0 0 0 0 Inf 2.79918348098377 Inf 0.00105652403592181 0.000287939890647285 0.00270289202199999 1 0.999770132403032 1 NA Interim based on WHO dataset 2) Assoc w R - Interim No change no Interim on WHO 1 +Pyrazinamide pncA p.Val155Gly pncA_p.Val155Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 10 9 1 9 1 4400 16821 0.00204127920163302 0.000933814369660709 0.00387143149170671 0.99994055403638 0.999668833292177 0.99999849495964 0.9 0.554983882971804 0.997471421455538 0.9 0.554983882971804 0.997471421455538 0.9 0.554983882971804 0.997471421455538 34.4065909090909 4.7638329340069 1496.2181371413 5.80523486805988e-06 108.5 1830 True False 34.4065909090909 4.7638329340069 1496.2181371413 0.00204127920163302 0.000933814369660709 0.00387143149170671 0.99994055403638 0.999668833292177 0.99999849495964 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 8 7 1 7 1 3779 16045 0.00184891706286318 0.000743673531480306 0.00380574231364529 0.999937679172379 0.999652820032955 0.999998422174497 0.875 0.473490329124793 0.996840276468748 0.875 0.473490329124793 0.996840276468748 0.875 0.473490329124793 0.996840276468748 29.7208256152421 3.81564410496199 1329.90635130009 6.13186242607604e-05 118.5 1762 True False 0 0 0 0 0 0 0 29.7208256152421 3.81564410496199 1329.90635130009 0.00184891706286318 0.000743673531480306 0.00380574231364529 0.999937679172379 0.999652820032955 0.999998422174497 34 Assoc w R Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Val155Leu pncA_p.Val155Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Val155Met pncA_p.Val155Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 8 1 8 1 4401 16821 0.00181447040145157 0.000783674794110066 0.0035720830153558 0.99994055403638 0.999668833292177 0.99999849495964 0.888888888888888 0.517503485082663 0.9971908632534 0.888888888888888 0.517503485082663 0.9971908632534 0.888888888888888 0.517503485082663 0.9971908632534 30.5766871165644 4.09674326327108 1347.13599331235 2.52655228636597e-05 121 1830 True False 30.5766871165644 4.09674326327108 1347.13599331235 0.00181447040145157 0.000783674794110066 0.0035720830153558 0.99994055403638 0.999668833292177 0.99999849495964 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 9 8 1 8 1 3778 16045 0.00211304807184363 0.00091269178353604 0.00415927925423806 0.999937679172379 0.999652820032955 0.999998422174497 0.888888888888888 0.517503485082663 0.9971908632534 0.888888888888888 0.517503485082663 0.9971908632534 0.888888888888888 0.517503485082663 0.9971908632534 33.9756484912652 4.55158722211531 1495.52925354629 1.3108272360446e-05 107.5 1762 True False 0 0 0 0 0 0 0 33.9756484912652 4.55158722211531 1495.52925354629 0.00211304807184363 0.00091269178353604 0.00415927925423806 0.999937679172379 0.999652820032955 0.999998422174497 15 Assoc w RI 1) Assoc w R UP from AwRI to AwR yes 4 +Pyrazinamide pncA p.Val157Ala pncA_p.Val157Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA p.Val157fs pncA_p.Val157fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Val157Gly pncA_p.Val157Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 8 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Val157Leu pncA_p.Val157Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Val163Ala pncA_p.Val163Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 3 1 3 1 4406 16821 0.000680426400544341 0.000140342268876931 0.00198719451371054 0.99994055403638 0.999668833292177 0.99999849495964 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 11.4532455742169 0.919224933680734 599.12689591493 0.030230719678465 231.5 1830 False False 11.4532455742169 0.919224933680734 599.12689591493 0.000680426400544341 0.000140342268876931 0.00198719451371054 0.99994055403638 0.999668833292177 0.99999849495964 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 3 2 1 2 1 3784 16045 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999937679172379 0.999652820032955 0.999998422174497 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 8.48044397463002 0.441282441622781 498.676520130596 0.0954034464341229 286.5 1762 False False 0 0 0 0 0 0 0 8.48044397463002 0.441282441622781 498.676520130596 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999937679172379 0.999652820032955 0.999998422174497 17 2) Assoc w R - Interim UP from Uncertain to AwRI yes 4 +Pyrazinamide pncA p.Val163fs pncA_p.Val163fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Val163Gly pncA_p.Val163Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 1 2 4408 16820 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999881108072762 0.999570588169705 0.999985601311719 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 1.9078947368421 0.0323314320919459 36.6634061310851 0.502600379724595 526 1830 False False 1.9078947368421 0.0323314320919459 36.6634061310851 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 1 2 3785 16044 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999875358344758 0.999549824781286 0.999984904960856 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 2.11941875825627 0.0359146288488272 40.7195918479678 0.470354459331036 493.5 1762 False False 0 0 0 0 0 0 0 2.11941875825627 0.0359146288488272 40.7195918479678 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999875358344758 0.999549824781286 0.999984904960856 11 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Val163Leu pncA_p.Val163Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Val163Met pncA_p.Val163Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA p.Val180Ala pncA_p.Val180Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 10 10 0 10 0 4399 16822 0.00226808800181447 0.00108815543692413 0.00416712622349087 1 0.999780735048249 1 1 0.691502892181239 1 1 0.691502892181239 1 1 0.691502892181239 1 Inf 8.56754994230848 Inf 1.47972618581065e-07 77 1830 True False Inf 8.56754994230848 Inf 0.00226808800181447 0.00108815543692413 0.00416712622349087 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 10 10 0 10 0 3776 16046 0.00264131008980454 0.00126731492930415 0.00485208155788738 1 0.999770132403032 1 1 0.691502892181239 1 1 0.691502892181239 1 1 0.691502892181239 1 Inf 9.51788812022163 Inf 6.36737245850332e-08 68 1762 True False 0 0 0 0 0 0 0 Inf 9.51788812022163 Inf 0.00264131008980454 0.00126731492930415 0.00485208155788738 1 0.999770132403032 1 23 Assoc w RI 1) Assoc w R UP from AwRI to AwR yes 4 +Pyrazinamide pncA p.Val180Asp pncA_p.Val180Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA p.Val180Gly pncA_p.Val180Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 9 0 9 0 4400 16822 0.00204127920163302 0.000933814369660709 0.00387143149170671 1 0.999780735048249 1 1 0.663732883120057 1 1 0.663732883120057 1 1 0.663732883120057 1 Inf 7.54177743415507 Inf 7.13698843528946e-07 90.5 1830 True False Inf 7.54177743415507 Inf 0.00204127920163302 0.000933814369660709 0.00387143149170671 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 7 7 0 7 0 3779 16046 0.00184891706286318 0.000743673531480306 0.00380574231364529 1 0.999770132403032 1 1 0.590383602774996 1 1 0.590383602774996 1 1 0.590383602774996 1 Inf 6.11594331475081 Inf 9.19916249305378e-06 102.5 1762 True False 0 0 0 0 0 0 0 Inf 6.11594331475081 Inf 0.00184891706286318 0.000743673531480306 0.00380574231364529 1 0.999770132403032 1 16 Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Val180Leu pncA_p.Val180Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 NA 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Val180Phe pncA_p.Val180Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 20 18 2 18 2 4391 16820 0.00408255840326604 0.00242132299966848 0.00644455638933336 0.999881108072762 0.999570588169705 0.999985601311719 0.9 0.683017285980917 0.987651472829705 0.9 0.683017285980917 0.987651472829705 0.9 0.683017285980917 0.987651472829705 34.4750626281029 8.24545388094397 306.241923347529 6.16477114570734e-11 52 1830 True False 34.4750626281029 8.24545388094397 306.241923347529 0.00408255840326604 0.00242132299966848 0.00644455638933336 0.999881108072762 0.999570588169705 0.999985601311719 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 13 13 0 13 0 3773 16046 0.0034337031167459 0.00182953006918454 0.00586457926930979 1 0.999770132403032 1 1 0.752947361999529 1 1 0.752947361999529 1 1 0.752947361999529 1 Inf 12.9516379657707 Inf 4.39880194628741e-10 51 1762 True False 0 0 0 0 0 0 0 Inf 12.9516379657707 Inf 0.0034337031167459 0.00182953006918454 0.00586457926930979 1 0.999770132403032 1 29 Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Val183Leu pncA_p.Val183Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Val21Ala pncA_p.Val21Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 1 6 4408 16816 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999643324218285 0.999223829869625 0.999869095386533 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.521823750104981 0 0 0.4592581264399 0 0 4.16460506207058 0.590719723256246 554.5 1830 False False 0.635813672111312 0.0138232628839914 5.24325822004213 0 0 0.000836510060464794 0.999643324218285 0.999223829869625 0.999869095386533 3) Uncertain significance 4) Not assoc w R - Interim WHO 4) Not assoc w R - interim 1 5 0 5 1 6 3785 16040 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999626075034276 0.999186301793093 0.999862764161372 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.521823750104981 0 0 0.4592581264399 0 0 4.62650046025696 0.590892150081256 515.5 1762 False False 0 0 0 0 0 0 0 0.706296785557023 0.0153546142757778 5.82369259713769 0 0 0.000974130102511011 0.999626075034276 0.999186301793093 0.999862764161372 18 Not assoc w RI 4) Not assoc w R - Interim No change yes 1 +Pyrazinamide pncA p.Val21fs pncA_p.Val21fs 1 frameshift (see "Genomic_coordinates" sheet) 1 3 2 1 2 1 4407 16821 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.99994055403638 0.999668833292177 0.99999849495964 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 7.63376446562287 0.397281353658273 449.052313013199 0.111452652175084 308.5 1830 False False 7.63376446562287 0.397281353658273 449.052313013199 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.99994055403638 0.999668833292177 0.99999849495964 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 3 2 1 2 1 3784 16045 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999937679172379 0.999652820032955 0.999998422174497 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 8.48044397463002 0.441282441622781 498.676520130596 0.0954034464341229 286.5 1762 False False 0 0 0 0 0 0 0 8.48044397463002 0.441282441622781 498.676520130596 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999937679172379 0.999652820032955 0.999998422174497 10 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Val21Gly pncA_p.Val21Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 14 12 2 12 2 4397 16820 0.00272170560217736 0.00140711126319081 0.00474944049676375 0.999881108072762 0.999570588169705 0.999985601311719 0.857142857142857 0.571870839090301 0.982205484516808 0.857142857142857 0.571870839090301 0.982205484516808 0.857142857142857 0.571870839090301 0.982205484516808 22.9520127359563 5.10587413136946 210.506455310098 3.78492538972851e-07 82 1830 True False 22.9520127359563 5.10587413136946 210.506455310098 0.00272170560217736 0.00140711126319081 0.00474944049676375 0.999881108072762 0.999570588169705 0.999985601311719 1) Assoc w R 2) Assoc w R - Interim WHO 2) Assoc w R - Interim 1 3 3 0 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 1.75196919627044 Inf 0.00695286470680484 189.5 1762 False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 4 Assoc w RI Interim based on WHO dataset 2) Assoc w R - Interim No change yes Interim on WHO 1 +Pyrazinamide pncA p.Val44Gly pncA_p.Val44Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 4 0 4 0 4405 16822 0.000907235200725788 0.000247244623732042 0.00232123869101376 1 0.999780735048249 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 2.51959224712996 Inf 0.00185784794966548 174 1830 True False Inf 2.51959224712996 Inf 0.000907235200725788 0.000247244623732042 0.00232123869101376 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 4 4 0 4 0 3782 16046 0.00105652403592181 0.000287939890647285 0.00270289202199999 1 0.999770132403032 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 2.79918348098377 Inf 0.0013264757267559 157.5 1762 True False 0 0 0 0 0 0 0 Inf 2.79918348098377 Inf 0.00105652403592181 0.000287939890647285 0.00270289202199999 1 0.999770132403032 1 8 Assoc w RI 2) Assoc w R - Interim No change yes 1 +Pyrazinamide pncA p.Val45Ala pncA_p.Val45Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Val45fs pncA_p.Val45fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Val45Gly pncA_p.Val45Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA p.Val45Met pncA_p.Val45Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.23555131695149 1 1273 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 3 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Val7Ala pncA_p.Val7Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 5 3 6 3 4403 16819 0.00136085280108868 0.000499567554195151 0.00295963286153356 0.999821662109142 0.999478910338162 0.999963220929399 0.666666666666666 0.29929505620854 0.925145368580308 0.625 0.244863216366551 0.914766585862746 0.625 0.244863216366551 0.914766585862746 6.36649254296313 1.23796469892989 41.0329329628386 0.0122524071489393 225 1830 False False 7.63979105155575 1.63062215603461 47.1843141162543 0.00113430127041742 0.000368403864880028 0.00264507905390205 0.999821662109142 0.999478910338162 0.999963220929399 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 8 5 3 6 3 3780 16043 0.00158478605388272 0.000581803608073282 0.0034461969631646 0.999813037517138 0.999453714469566 0.999961442181588 0.666666666666666 0.29929505620854 0.925145368580308 0.625 0.244863216366551 0.914766585862746 0.625 0.244863216366551 0.914766585862746 7.07363315696649 1.3753817585347 45.5500095380883 0.00844828680953882 202 1762 False False 0 0 0 0 0 0 0 8.48835978835978 1.81156966816674 52.4815945931853 0.00132100396301188 0.000429061121297529 0.00308006778073064 0.999813037517138 0.999453714469566 0.999961442181588 14 Assoc w R 2) Assoc w R - Interim DOWN from AwR to AwRI yes 3 +Pyrazinamide pncA p.Val7del pncA_p.Val7del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1335 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1283 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Pyrazinamide pncA p.Val7fs pncA_p.Val7fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.716637886286628 Inf 0.0431182613129385 265.5 1830 False False Inf 0.716637886286628 Inf 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 2 2 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.796077158748321 Inf 0.0364363919492442 248 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 NA 2) Assoc w R - Interim No change no 1 +Pyrazinamide pncA p.Val7Gly pncA_p.Val7Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 34 32 2 34 2 4375 16820 0.00771149920616919 0.00534617862297411 0.0107595218761754 0.999881108072762 0.999570588169705 0.999985601311719 0.944444444444444 0.813363293542446 0.993199699345977 0.941176470588235 0.803226790664424 0.99279508256095 0.941176470588235 0.803226790664424 0.99279508256095 61.5131428571428 15.6799514780689 529.135636131217 4.64511477987081e-20 27 1830 True False 65.3577142857142 16.7407471983 560.803227409164 0.00726117540276832 0.00497178645234357 0.01023528015412 0.999881108072762 0.999570588169705 0.999985601311719 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 34 32 2 34 2 3752 16044 0.00898045430533544 0.00622701536814537 0.0125268703397902 0.999875358344758 0.999549824781286 0.999984904960856 0.944444444444444 0.813363293542446 0.993199699345977 0.941176470588235 0.803226790664424 0.99279508256095 0.941176470588235 0.803226790664424 0.99279508256095 68.4179104477611 17.4446519236876 588.483500133008 3.2099241825002e-21 19.5 1762 True False 0 0 0 0 0 0 0 72.6940298507462 18.6184986633149 623.739204211696 0.00845665961945031 0.00579133438122877 0.0119174801683906 0.999875358344758 0.999549824781286 0.999984904960856 41 Assoc w R Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Val7Ile pncA_p.Val7Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Pyrazinamide pncA p.Val7Leu pncA_p.Val7Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 8 0 8 0 4401 16822 0.00181447040145157 0.000783674794110066 0.0035720830153558 1 0.999780735048249 1 1 0.63058335244718 1 1 0.63058335244718 1 1 0.63058335244718 1 Inf 6.5206569685433 Inf 3.44167929021015e-06 103.5 1830 True False Inf 6.5206569685433 Inf 0.00181447040145157 0.000783674794110066 0.0035720830153558 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 8 8 0 8 0 3778 16046 0.00211304807184363 0.00091269178353604 0.00415927925423806 1 0.999770132403032 1 1 0.63058335244718 1 1 0.63058335244718 1 1 0.63058335244718 1 Inf 7.24385478693174 Inf 1.75352509766709e-06 91 1762 True False 0 0 0 0 0 0 0 Inf 7.24385478693174 Inf 0.00211304807184363 0.00091269178353604 0.00415927925423806 1 0.999770132403032 1 4 Assoc w R 1) Assoc w R No change yes 1 +Pyrazinamide pncA p.Val7Phe pncA_p.Val7Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 3 0 4 0 4405 16822 0.000907235200725788 0.000247244623732042 0.00232123869101376 1 0.999780735048249 1 1 0.397635364383525 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 1.57738761951872 Inf 0.0089462394691195 203 1830 False False Inf 2.51959224712996 Inf 0.000680580762250453 0.000140374111950171 0.0019876450342228 1 0.999780735048249 1 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 2 2 0 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.796287283318118 Inf 0.0364208169216465 224.5 1762 False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf 0.000528401585204755 6.39982904626514e-05 0.00190745126237675 1 0.999770132403032 1 4 2) Assoc w R - Interim UP from Uncertain to AwRI yes 4 +Pyrazinamide pncA p.Val93Ala pncA_p.Val93Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 2 2 2 2 4407 16820 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.999881108072762 0.999570588169705 0.999985601311719 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 3.8166553210801 0.276553001924986 52.6392074577436 0.192674584671704 327.5 1830 False False 3.8166553210801 0.276553001924986 52.6392074577436 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.999881108072762 0.999570588169705 0.999985601311719 2) Assoc w R - Interim 2) Assoc w R - Interim ALL+WHO 2) Assoc w R - Interim 1 4 2 2 2 2 3784 16044 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999875358344758 0.999549824781286 0.999984904960856 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 4.2399577167019 0.307210542317908 58.5302826936734 0.166974861221294 305 1762 False False 0 0 0 0 0 0 0 4.2399577167019 0.307210542317908 58.5302826936734 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999875358344758 0.999549824781286 0.999984904960856 3 2) Assoc w R - Interim UP from Uncertain to AwRI yes 4 +Pyrazinamide pncA p.Val93Gly pncA_p.Val93Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 4408 16821 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 3.81601633393829 0.0486026416232846 298.829108180248 0.372217803874758 506.5 1830 False False 3.81601633393829 0.0486026416232846 298.829108180248 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA p.Val93Leu pncA_p.Val93Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 5 0 5 0 4404 16822 0.00113404400090723 0.000368320285107068 0.00264447958048867 1 0.999780735048249 1 1 0.478176249895018 1 1 0.478176249895018 1 1 0.478176249895018 1 Inf 3.49836879238979 Inf 0.000385538239896191 148 1830 True False Inf 3.49836879238979 Inf 0.00113404400090723 0.000368320285107068 0.00264447958048867 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Evidence from ALL dataset only 2) Assoc w R - Interim New AwRI yes ALL only 5 +Pyrazinamide pncA p.Val93Met pncA_p.Val93Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA p.Val9Ala pncA_p.Val9Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 4408 16821 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 3.81601633393829 0.0486026416232846 298.829108180248 0.372217803874758 506.5 1830 False False 3.81601633393829 0.0486026416232846 298.829108180248 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 3785 16045 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 4.23910171730515 0.0539892730999128 331.863925136224 0.345370788365398 466.5 1762 False False 0 0 0 0 0 0 0 4.23910171730515 0.0539892730999128 331.863925136224 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 8 3) Uncertain significance New Uncertain no 0 +Pyrazinamide pncA p.Val9Gly pncA_p.Val9Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 10 10 0 10 0 4399 16822 0.00226808800181447 0.00108815543692413 0.00416712622349087 1 0.999780735048249 1 1 0.691502892181239 1 1 0.691502892181239 1 1 0.691502892181239 1 Inf 8.56754994230848 Inf 1.47972618581065e-07 77 1830 True False Inf 8.56754994230848 Inf 0.00226808800181447 0.00108815543692413 0.00416712622349087 1 0.999780735048249 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 9 9 0 9 0 3777 16046 0.00237717908082408 0.00108755584228183 0.00450780893694816 1 0.999770132403032 1 1 0.663732883120057 1 1 0.663732883120057 1 1 0.663732883120057 1 Inf 8.37964612204265 Inf 3.34181689819727e-07 76.5 1762 True False 0 0 0 0 0 0 0 Inf 8.37964612204265 Inf 0.00237717908082408 0.00108755584228183 0.00450780893694816 1 0.999770132403032 1 8 Assoc w RI 1) Assoc w R UP from AwRI to AwR yes 4 +Pyrazinamide PPE35 c.1005C>A PPE35_c.1005C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.1020C>T PPE35_c.1020C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.23555131695149 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.2590571436125 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.1026G>A PPE35_c.1026G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.1056C>T PPE35_c.1056C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.23555131695149 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.2590571436125 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.1062C>A PPE35_c.1062C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.1062C>T PPE35_c.1062C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.1084C>T PPE35_c.1084C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.-108A>G PPE35_c.-108A>G 2 upstream_gene_variant 2170720 1 1 0 1 3 2 4406 16820 0.000680426400544341 0.000140342268876931 0.00198719451371054 0.999881108072762 0.999570588169705 0.999985601311719 0.6 0.146632799634673 0.947255049473683 0 0 0.975 0 0 0.841886116991581 0 0 148.54892330925 1 1273 1830 False False 5.72628234226055 0.655677739135472 68.675028521871 0 0 0.000836889615584862 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 2 3783 16044 0.000792393026941363 0.000163440311798119 0.00231394549068866 0.999875358344758 0.999549824781286 0.999984904960856 0.6 0.146632799634673 0.947255049473683 0 0 0.975 0 0 0.841886116991581 0 0 164.988524968396 1 927 1762 False False 0 0 0 0 0 0 0 6.36161776367961 0.728392675067714 76.0575760881352 0 0 0.000974644855475749 0.999875358344758 0.999549824781286 0.999984904960856 8 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 c.108C>T PPE35_c.108C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.1107G>A PPE35_c.1107G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.-110G>A PPE35_c.-110G>A 2 upstream_gene_variant 2170722 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 c.1119C>T PPE35_c.1119C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.-112T>C PPE35_c.-112T>C 2 upstream_gene_variant 2170724 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 c.-112T>G PPE35_c.-112T>G 2 upstream_gene_variant 2170724 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 c.1134C>T PPE35_c.1134C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.-114_-113insTG PPE35_c.-114_-113insTG 2 upstream_gene_variant 2170725 1 0 0 0 1 1 4408 16821 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1456 1830 False False 3.81601633393829 0.0486026416232846 298.829108180248 0 0 0.000836510060464794 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 c.-114G>A PPE35_c.-114G>A 2 upstream_gene_variant 2170726 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 2 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 c.1152C>A PPE35_c.1152C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.23555131695149 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.2590571436125 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.1179C>T PPE35_c.1179C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0978301145652783 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.1188G>A PPE35_c.1188G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.-119C>T PPE35_c.-119C>T 2 upstream_gene_variant 2170731 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 3 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 c.-11G>A PPE35_c.-11G>A 2 upstream_gene_variant 2170623 0 0 0 0 7 35 4402 16787 0.00158766160127012 0.000638553061192671 0.00326843667440656 0.997919391273332 0.99710755346706 0.998550365049612 0.166666666666666 0.069740663655675 0.313640866880671 NA NA NA 0 0 0.100032435572105 NA NA NA NA 1531 1830 False False 0.76269877328487 0.285700721321139 1.74420294792069 0 0 0.000837649760071483 0.997919391273332 0.99710755346706 0.998550365049612 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 7 35 3779 16011 0.00184891706286318 0.000743673531480306 0.00380574231364529 0.997818771033279 0.996967731633935 0.998480238265245 0.166666666666666 0.069740663655675 0.313640866880671 NA NA NA 0 0 0.100032435572105 NA NA NA NA 1466 1762 False False 0 0 0 0 0 0 0 0.847367028314368 0.317384901275899 1.93805322080542 0 0 0.000975675995176254 0.997818771033279 0.996967731633935 0.998480238265245 79 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 c.1200T>A PPE35_c.1200T>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.-122T>G PPE35_c.-122T>G 2 upstream_gene_variant 2170734 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 c.1230C>G PPE35_c.1230C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 3 4408 16819 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999821662109142 0.999478910338162 0.999963220929399 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.2718542044767 0.0242215257537785 15.8425197757275 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 3 3785 16043 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999813037517138 0.999453714469566 0.999961442181588 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.41285777190664 0.0269058536042688 17.5998124179982 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.123T>G PPE35_c.123T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.1257C>T PPE35_c.1257C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 12 4409 16810 0 0 0.000836320411980403 0.999286648436571 0.998754250286254 0.999631348241016 0 0 0.264648469397051 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.37280707722974 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 12 3786 16034 0 0 0.000973872929872615 0.999252150068553 0.998694021458847 0.999613517219799 0 0 0.264648469397051 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.52501633506388 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.126T>C PPE35_c.126T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0978301145652783 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.1275C>A PPE35_c.1275C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.129C>T PPE35_c.129C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0978301145652783 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.1302G>A PPE35_c.1302G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.132T>G PPE35_c.132T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 4409 16818 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.78028251232769 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 3786 16042 0 0 0.000973872929872615 0.999750716689517 0.999361859844744 0.999932074644789 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.42109836734015 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.1338G>A PPE35_c.1338G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.138C>A PPE35_c.138C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 4409 16818 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.78028251232769 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 3786 16042 0 0 0.000973872929872615 0.999750716689517 0.999361859844744 0.999932074644789 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.42109836734015 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.1392T>C PPE35_c.1392T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 19 4405 16803 0.000907235200725788 0.000247244623732042 0.00232123869101376 0.998870526691237 0.998236746975561 0.999319850622688 0.17391304347826 0.0495076453057934 0.387811889954797 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.803058725132923 0.198587940276389 2.41813321540217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 4 19 3782 16027 0.00105652403592181 0.000287939890647285 0.00270289202199999 0.998815904275208 0.99815150272858 0.999286951215351 0.17391304347826 0.0495076453057934 0.387811889954797 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.892148403796376 0.220599690766996 2.68683222841427 NA NA NA NA NA NA 35 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.1443C>G PPE35_c.1443C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.1464G>A PPE35_c.1464G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 7 4409 16815 0 0 0.000836320411980403 0.999583878254666 0.99914281931165 0.999832681632407 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.64713852578052 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 7 3786 16039 0 0 0.000973872929872615 0.999563754206656 0.999101374817905 0.99982458915172 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.94057641353956 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.1464G>C PPE35_c.1464G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 31 4408 16791 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.998157175127808 0.997385268251665 0.998747557085331 0.03125 0.000790868597952557 0.162170994181511 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.122877758913412 0.00301812489649231 0.737803764877926 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 29 3785 16017 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.998192695999002 0.997405433184333 0.998789296399478 0.0333333333333333 0.000843570926630479 0.172169455633412 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.14592083086594 0.00357555961337945 0.880733582721516 NA NA NA NA NA NA 44 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.1479G>A PPE35_c.1479G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 4409 16818 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.78028251232769 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 3786 16042 0 0 0.000973872929872615 0.999750716689517 0.999361859844744 0.999932074644789 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.42109836734015 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.147A>C PPE35_c.147A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.1482C>T PPE35_c.1482C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 4409 16817 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.16390782018879 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 5 3786 16041 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.62556638995023 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.1488T>G PPE35_c.1488T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.23555131695149 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.2590571436125 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.1491C>G PPE35_c.1491C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 4 4408 16818 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999762216145523 0.999391291831884 0.999935208223951 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.95383393829401 0.0193637820130019 9.63941079069668 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 4 3785 16042 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999750716689517 0.999361859844744 0.999932074644789 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.05957727873183 0.0215096981131212 10.714411563858 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.1542A>G PPE35_c.1542A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.1545G>A PPE35_c.1545G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.1557A>G PPE35_c.1557A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 7 4409 16815 0 0 0.000836320411980403 0.999583878254666 0.99914281931165 0.999832681632407 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.64713852578052 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 7 3786 16039 0 0 0.000973872929872615 0.999563754206656 0.999101374817905 0.99982458915172 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.94057641353956 NA NA NA NA NA NA 19 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.1560T>C PPE35_c.1560T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 10 4409 16812 0 0 0.000836320411980403 0.999405540363809 0.998907040193061 0.999714897863756 0 0 0.30849710781876 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 0 1.70188592764298 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 0 10 3786 16036 0 0 0.000973872929872615 0.999376791723794 0.998854197426924 0.999701108243012 0 0 0.30849710781876 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 0 0 0 1.89058845367291 NA NA NA NA NA NA 35 5) Not assoc w R Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.1569G>C PPE35_c.1569G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 7 4409 16815 0 0 0.000836320411980403 0.999583878254666 0.99914281931165 0.999832681632407 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.64713852578052 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 7 3786 16039 0 0 0.000973872929872615 0.999563754206656 0.999101374817905 0.99982458915172 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.94057641353956 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.1572G>A PPE35_c.1572G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.23555131695149 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA 11 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.1590G>A PPE35_c.1590G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 9 4409 16813 0 0 0.000836320411980403 0.999464986327428 0.998984621445092 0.999755329427402 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.9328143827158 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 9 3786 16037 0 0 0.000973872929872615 0.999439112551414 0.998935529133907 0.999743495490327 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.14715011586227 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.1626A>G PPE35_c.1626A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 8 4408 16814 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999524432291047 0.999063158238902 0.999794661972981 0.111111111111111 0.00280913674659921 0.482496514917337 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.476803539019963 0.0107465349444348 3.55811644738743 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 7 3785 16039 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999563754206656 0.999101374817905 0.99982458915172 0.125 0.0031597235312519 0.526509670875206 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.605359501792791 0.0134317907447528 4.71432113745169 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.1632A>G PPE35_c.1632A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 8 4408 16814 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999524432291047 0.999063158238902 0.999794661972981 0.111111111111111 0.00280913674659921 0.482496514917337 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.476803539019963 0.0107465349444348 3.55811644738743 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 7 3785 16039 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999563754206656 0.999101374817905 0.99982458915172 0.125 0.0031597235312519 0.526509670875206 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.605359501792791 0.0134317907447528 4.71432113745169 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.1635A>C PPE35_c.1635A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.1638C>T PPE35_c.1638C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 6 4408 16816 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999643324218285 0.999223829869625 0.999869095386533 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.635813672111312 0.0138232628839914 5.24325822004213 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 5 3785 16041 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999688395861897 0.99927297097682 0.999898815491092 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.847608982826948 0.0179160496983802 7.57805461545705 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.1650A>G PPE35_c.1650A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 4 4408 16818 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999762216145523 0.999391291831884 0.999935208223951 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.95383393829401 0.0193637820130019 9.63941079069668 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 4 3785 16042 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999750716689517 0.999361859844744 0.999932074644789 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.05957727873183 0.0215096981131212 10.714411563858 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.1656G>A PPE35_c.1656G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.1668T>C PPE35_c.1668T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.1701G>A PPE35_c.1701G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.1761G>T PPE35_c.1761G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0978301145652783 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.1791G>A PPE35_c.1791G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 10 4409 16812 0 0 0.000836320411980403 0.999405540363809 0.998907040193061 0.999714897863756 0 0 0.30849710781876 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.70188592764298 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 10 3786 16036 0 0 0.000973872929872615 0.999376791723794 0.998854197426924 0.999701108243012 0 0 0.30849710781876 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.89058845367291 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.-17C>T PPE35_c.-17C>T 2 upstream_gene_variant 2170629 1 0 0 0 2 3 4407 16819 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.999821662109142 0.999478910338162 0.999963220929399 0.4 0.0527449505263169 0.853367200365326 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1594 1830 False False 2.5442856062325 0.212429984141661 22.2163543346012 0 0 0.000836699794980095 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 3 3784 16043 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999813037517138 0.999453714469566 0.999961442181588 0.4 0.0527449505263169 0.853367200365326 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1527 1762 False False 0 0 0 0 0 0 0 2.82646229739253 0.235979261609975 24.6811314932427 0 0 0.000974387411009493 0.999813037517138 0.999453714469566 0.999961442181588 4 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 c.1803T>G PPE35_c.1803T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.180G>A PPE35_c.180G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.1824C>T PPE35_c.1824C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.1932T>C PPE35_c.1932T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.1935C>T PPE35_c.1935C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.1941C>T PPE35_c.1941C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.1960T>C PPE35_c.1960T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.1971C>T PPE35_c.1971C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2010C>T PPE35_c.2010C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2013G>A PPE35_c.2013G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 11 4409 16811 0 0 0.000836320411980403 0.99934609440019 0.998830284178405 0.999673528922672 0 0 0.284914152918154 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.51991683293768 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 11 3786 16035 0 0 0.000973872929872615 0.999314470896173 0.998773730902855 0.999657738248111 0 0 0.284914152918154 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.68837982812114 NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.201G>A PPE35_c.201G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.23555131695149 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.2590571436125 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2034C>T PPE35_c.2034C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2046A>C PPE35_c.2046A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2049T>G PPE35_c.2049T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.204G>A PPE35_c.204G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2055C>G PPE35_c.2055C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2061T>C PPE35_c.2061T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2067T>G PPE35_c.2067T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2073C>T PPE35_c.2073C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2085T>C PPE35_c.2085T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.23555131695149 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.2590571436125 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2118C>T PPE35_c.2118C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2136C>G PPE35_c.2136C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2139C>T PPE35_c.2139C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2142C>T PPE35_c.2142C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2148C>T PPE35_c.2148C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2160C>G PPE35_c.2160C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 4409 16818 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.78028251232769 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 3786 16042 0 0 0.000973872929872615 0.999750716689517 0.999361859844744 0.999932074644789 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.42109836734015 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.216T>C PPE35_c.216T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0978301145652783 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2190G>A PPE35_c.2190G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.219G>C PPE35_c.219G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.716637886286628 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.21G>A PPE35_c.21G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2235C>T PPE35_c.2235C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2238T>C PPE35_c.2238T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2241G>A PPE35_c.2241G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2250G>A PPE35_c.2250G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 6 4408 16816 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999643324218285 0.999223829869625 0.999869095386533 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.635813672111312 0.0138232628839914 5.24325822004213 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 6 3785 16040 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999626075034276 0.999186301793093 0.999862764161372 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.706296785557023 0.0153546142757778 5.82369259713769 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2286G>A PPE35_c.2286G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.228G>A PPE35_c.228G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2295T>C PPE35_c.2295T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2310G>T PPE35_c.2310G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 45 4407 16777 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.997324931637142 0.996422167208985 0.99804813798441 0.0425531914893617 0.00519558317674383 0.145405245488214 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.169195471850339 0.0198804185003422 0.648224781244469 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 44 3784 16002 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.997257883584694 0.996320565686837 0.998006888604001 0.0434782608695652 0.00530948284942996 0.148386775920115 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.192220834134153 0.0225643634793223 0.737454695157596 NA NA NA NA NA NA 51 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2313C>T PPE35_c.2313C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.231C>T PPE35_c.231C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2320T>C PPE35_c.2320T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0978301145652783 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2346T>G PPE35_c.2346T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2358G>A PPE35_c.2358G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0978301145652783 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.237G>A PPE35_c.237G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2424T>G PPE35_c.2424T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2448G>A PPE35_c.2448G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 1 4405 16821 0.000907235200725788 0.000247244623732042 0.00232123869101376 0.99994055403638 0.999668833292177 0.99999849495964 0.8 0.28358206388191 0.994949236620532 NA NA NA NA NA NA NA NA NA NA NA NA False False 15.2744608399545 1.5107888308703 749.051486258063 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2466A>G PPE35_c.2466A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 4409 16818 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.78028251232769 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 3786 16042 0 0 0.000973872929872615 0.999750716689517 0.999361859844744 0.999932074644789 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.42109836734015 NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2469G>T PPE35_c.2469G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.246G>A PPE35_c.246G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.249C>T PPE35_c.249C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2526G>A PPE35_c.2526G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2526G>T PPE35_c.2526G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 4409 16818 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.78028251232769 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 3786 16042 0 0 0.000973872929872615 0.999750716689517 0.999361859844744 0.999932074644789 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.42109836734015 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2541A>G PPE35_c.2541A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2586C>T PPE35_c.2586C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2619C>T PPE35_c.2619C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2625C>A PPE35_c.2625C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2631C>T PPE35_c.2631C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0978301145652783 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2646A>G PPE35_c.2646A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2655G>A PPE35_c.2655G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2682C>T PPE35_c.2682C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0978301145652783 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2715G>C PPE35_c.2715G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2721G>A PPE35_c.2721G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2739C>T PPE35_c.2739C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2751G>A PPE35_c.2751G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2790C>T PPE35_c.2790C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.282G>A PPE35_c.282G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2841C>T PPE35_c.2841C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.285C>G PPE35_c.285C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0978301145652783 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2865C>T PPE35_c.2865C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2868C>G PPE35_c.2868C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2875C>T PPE35_c.2875C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 1 4406 16821 0.000680426400544341 0.000140342268876931 0.00198719451371054 0.99994055403638 0.999668833292177 0.99999849495964 0.75 0.194120449683243 0.99369053679029 NA NA NA NA NA NA NA NA NA NA NA NA False False 11.4532455742169 0.919224933680734 599.12689591493 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 1 3783 16045 0.000792393026941363 0.000163440311798119 0.00231394549068866 0.999937679172379 0.999652820032955 0.999998422174497 0.75 0.194120449683243 0.99369053679029 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 12.7240285487708 1.02115021686679 665.307410149575 NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.-28C>T PPE35_c.-28C>T 2 upstream_gene_variant 2170640 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 c.2904C>T PPE35_c.2904C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2910G>A PPE35_c.2910G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2916C>T PPE35_c.2916C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 4409 16817 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.16390782018879 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 5 3786 16041 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.62556638995023 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2919C>A PPE35_c.2919C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2922C>T PPE35_c.2922C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2931G>A PPE35_c.2931G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2934G>A PPE35_c.2934G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.294G>A PPE35_c.294G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2958G>A PPE35_c.2958G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2961A>G PPE35_c.2961A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 4409 16818 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.78028251232769 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 3786 16042 0 0 0.000973872929872615 0.999750716689517 0.999361859844744 0.999932074644789 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.42109836734015 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.2964A>G PPE35_c.2964A>G 2 stop_retained_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.300G>C PPE35_c.300G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 9 4409 16813 0 0 0.000836320411980403 0.999464986327428 0.998984621445092 0.999755329427402 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.9328143827158 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 9 3786 16037 0 0 0.000973872929872615 0.999439112551414 0.998935529133907 0.999743495490327 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.14715011586227 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.-30C>A PPE35_c.-30C>A 2 upstream_gene_variant 2170642 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 c.315A>G PPE35_c.315A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.324G>A PPE35_c.324G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.327G>A PPE35_c.327G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.333C>G PPE35_c.333C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.351C>T PPE35_c.351C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.-35A>G PPE35_c.-35A>G 2 upstream_gene_variant 2170647 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 c.363G>A PPE35_c.363G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 3 4408 16819 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999821662109142 0.999478910338162 0.999963220929399 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.2718542044767 0.0242215257537785 15.8425197757275 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 3 3785 16043 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999813037517138 0.999453714469566 0.999961442181588 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.41285777190664 0.0269058536042688 17.5998124179982 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.381T>C PPE35_c.381T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.39C>T PPE35_c.39C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.-41_-39delCCT PPE35_c.-41_-39delCCT 2 upstream_gene_variant 2170650 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 c.420C>T PPE35_c.420C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0978301145652783 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.-42A>G PPE35_c.-42A>G 2 upstream_gene_variant 2170654 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 c.447G>C PPE35_c.447G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.456G>A PPE35_c.456G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 4409 16818 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.78028251232769 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 3786 16042 0 0 0.000973872929872615 0.999750716689517 0.999361859844744 0.999932074644789 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.42109836734015 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.-45G>A PPE35_c.-45G>A 2 upstream_gene_variant 2170657 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 c.471G>T PPE35_c.471G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.474G>A PPE35_c.474G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 4409 16818 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.78028251232769 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 3786 16042 0 0 0.000973872929872615 0.999750716689517 0.999361859844744 0.999932074644789 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.42109836734015 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.-48_-47delCG PPE35_c.-48_-47delCG 2 upstream_gene_variant 2170658 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1473 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1408 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 c.486T>G PPE35_c.486T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.504C>T PPE35_c.504C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.516G>A PPE35_c.516G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.519G>T PPE35_c.519G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 4409 16816 0 0 0.000836320411980403 0.999643324218285 0.999223829869625 0.999869095386533 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.24030155506377 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 6 3786 16040 0 0 0.000973872929872615 0.999626075034276 0.999186301793093 0.999862764161372 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.59982301180526 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.525G>C PPE35_c.525G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.528G>A PPE35_c.528G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.528G>C PPE35_c.528G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.54G>C PPE35_c.54G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 18 4408 16804 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.998929972654856 0.998309420654136 0.99936571457723 0.0526315789473684 0.00133162880417942 0.260280654195214 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.211786650534381 0.00508563060577416 1.34215228288193 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 18 3785 16028 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.998878225102829 0.998227689237744 0.999335033867569 0.0526315789473684 0.00133162880417942 0.260280654195214 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.235256127990606 0.00564851425373584 1.49102455534335 NA NA NA NA NA NA 41 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.561C>T PPE35_c.561C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.23555131695149 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.2590571436125 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.573G>A PPE35_c.573G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.579G>A PPE35_c.579G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0978301145652783 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.-57G>A PPE35_c.-57G>A 2 upstream_gene_variant 2170669 1 0 0 0 1 30 4408 16792 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.998216621091428 0.997455086506808 0.99879644827958 0.032258064516129 0.000816370071846613 0.167021116230227 NA NA NA 0 0 0.115703308222027 NA NA NA NA 1498 1830 False False 0.126981246218995 0.00311557232559072 0.764318374666763 0 0 0.000836510060464794 0.998216621091428 0.997455086506808 0.99879644827958 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 30 3785 16016 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.998130375171382 0.997332061268946 0.998738227457322 0.032258064516129 0.000816370071846613 0.167021116230227 NA NA NA 0 0 0.115703308222027 NA NA NA NA 1434 1762 False False 0 0 0 0 0 0 0 0.141047996477322 0.00346009100591229 0.849070579190256 0 0 0.000974130102511011 0.998130375171382 0.997332061268946 0.998738227457322 32 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 c.582C>T PPE35_c.582C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 4409 16816 0 0 0.000836320411980403 0.999643324218285 0.999223829869625 0.999869095386533 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.24030155506377 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 6 3786 16040 0 0 0.000973872929872615 0.999626075034276 0.999186301793093 0.999862764161372 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.59982301180526 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.597C>G PPE35_c.597C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.-5G>A PPE35_c.-5G>A 2 upstream_gene_variant 2170617 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1537 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1472 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 c.603G>C PPE35_c.603G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.-63G>C PPE35_c.-63G>C 2 upstream_gene_variant 2170675 1 23 1 22 2 32 4407 16790 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.998097729164189 0.997315612940588 0.99869849551898 0.0588235294117647 0.00720491743904971 0.196773209335575 0.0434782608695652 0.0011001686304415 0.21948660745348 0.0303030303030303 0.000766912075048109 0.157593972272496 0.173174907688182 0.00419884642040715 1.07200626784958 0.0673667168285353 296 1830 False False 0.23811549807125 0.0276371307037841 0.933990391901813 0.000226860254083484 5.74358785768897e-06 0.0012633291757201 0.998097729164189 0.997315612940588 0.99869849551898 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 23 1 22 1 32 3785 16014 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.998005733516141 0.997185846734806 0.998635535618626 0.0303030303030303 0.000766912075048109 0.157593972272496 0.0434782608695652 0.0011001686304415 0.21948660745348 0.0303030303030303 0.000766912075048109 0.157593972272496 0.192314158760658 0.00466224564251074 1.19058446758111 0.105650830156729 292 1762 False False 0 0 0 0 0 0 0 0.132215984147952 0.00325015718952304 0.792077375155062 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.998005733516141 0.997185846734806 0.998635535618626 35 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 c.642T>C PPE35_c.642T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 8 4409 16814 0 0 0.000836320411980403 0.999524432291047 0.999063158238902 0.999794661972981 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.2350715489366 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 8 3786 16038 0 0 0.000973872929872615 0.999501433379035 0.999017862631239 0.999784730530787 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.48286669292342 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.645C>T PPE35_c.645C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.648C>T PPE35_c.648C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 4409 16816 0 0 0.000836320411980403 0.999643324218285 0.999223829869625 0.999869095386533 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.24030155506377 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 6 3786 16040 0 0 0.000973872929872615 0.999626075034276 0.999186301793093 0.999862764161372 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.59982301180526 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.-65G>A PPE35_c.-65G>A 2 upstream_gene_variant 2170677 1 1 0 1 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 148.448081147381 1 1273 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 164.858125974995 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 c.666T>C PPE35_c.666T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.678C>T PPE35_c.678C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.-67A>G PPE35_c.-67A>G 2 upstream_gene_variant 2170679 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1627 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1558 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 c.699C>A PPE35_c.699C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 7 4409 16815 0 0 0.000836320411980403 0.999583878254666 0.99914281931165 0.999832681632407 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.64713852578052 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 7 3786 16039 0 0 0.000973872929872615 0.999563754206656 0.999101374817905 0.99982458915172 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.94057641353956 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.-69G>A PPE35_c.-69G>A 2 upstream_gene_variant 2170681 1 1 0 1 4 1 4405 16821 0.000907235200725788 0.000247244623732042 0.00232123869101376 0.99994055403638 0.999668833292177 0.99999849495964 0.8 0.28358206388191 0.994949236620532 0 0 0.975 0 0 0.975 0 0 148.591380466603 1 1273 1830 False False 15.2744608399545 1.5107888308703 749.051486258063 0 0 0.000837079522337697 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 4 1 3782 16045 0.00105652403592181 0.000287939890647285 0.00270289202199999 0.999937679172379 0.999652820032955 0.999998422174497 0.8 0.28358206388191 0.994949236620532 0 0 0.975 0 0 0.975 0 0 165.04229620263 1 927 1762 False False 0 0 0 0 0 0 0 16.9698572184029 1.67834059794994 831.753865754 0 0 0.000974902436017582 0.999937679172379 0.999652820032955 0.999998422174497 27 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 c.711G>A PPE35_c.711G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 9 4408 16813 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999464986327428 0.998984621445092 0.999755329427402 0.1 0.00252857854446178 0.445016117028195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.423800161322847 0.0096702825982498 3.05978219977364 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 9 3785 16037 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999439112551414 0.998935529133907 0.999743495490327 0.1 0.00252857854446178 0.445016117028195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.470776456773814 0.0107413348195793 3.39934587117999 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.714G>T PPE35_c.714G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.720C>A PPE35_c.720C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.-72T>G PPE35_c.-72T>G 2 upstream_gene_variant 2170684 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1457 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1392 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 c.735C>T PPE35_c.735C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 4409 16818 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.78028251232769 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 3786 16042 0 0 0.000973872929872615 0.999750716689517 0.999361859844744 0.999932074644789 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.42109836734015 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.765C>T PPE35_c.765C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.786G>A PPE35_c.786G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.789C>A PPE35_c.789C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.807T>C PPE35_c.807T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 4408 16820 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999881108072762 0.999570588169705 0.999985601311719 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.9078947368421 0.0323314320919459 36.6634061310851 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 3785 16044 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999875358344758 0.999549824781286 0.999984904960856 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.11941875825627 0.0359146288488272 40.7195918479678 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.-80T>G PPE35_c.-80T>G 2 upstream_gene_variant 2170692 1 1 0 1 6 2 4403 16820 0.00136085280108868 0.000499567554195151 0.00295963286153356 0.999881108072762 0.999570588169705 0.999985601311719 0.75 0.349144205587175 0.968145973750055 0 0 0.975 0 0 0.841886116991581 0 0 148.649902570288 1 1273 1830 False False 11.4603679309561 2.04817323907972 116.208277323028 0 0 0.000837459594522268 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 3784 16045 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999937679172379 0.999652820032955 0.999998422174497 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 164.955289378195 1 554.5 1762 False False 0 0 0 0 0 0 0 8.48044397463002 0.441282441622781 498.676520130596 0 0 0.000974387411009493 0.999937679172379 0.999652820032955 0.999998422174497 16 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 c.819C>A PPE35_c.819C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.-81C>T PPE35_c.-81C>T 2 upstream_gene_variant 2170693 1 2 0 2 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.3214799903419 1 1273 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 22.56946568665 1 927 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 c.-82T>C PPE35_c.-82T>C 2 upstream_gene_variant 2170694 NA 0 0 0 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1595 1830 False False Inf 1.57702975056642 Inf 0 0 0.000836889615584862 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1528 1762 False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf 0 0 0.000974644855475749 1 0.999770132403032 1 5 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 c.834A>C PPE35_c.834A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 1 4407 16821 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.99994055403638 0.999668833292177 0.99999849495964 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 7.63376446562287 0.397281353658273 449.052313013199 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 1 3784 16045 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999937679172379 0.999652820032955 0.999998422174497 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 8.48044397463002 0.441282441622781 498.676520130596 NA NA NA NA NA NA 22 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.837C>T PPE35_c.837C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.846A>C PPE35_c.846A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.870G>A PPE35_c.870G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.-89C>T PPE35_c.-89C>T 2 upstream_gene_variant 2170701 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 1 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 c.901C>T PPE35_c.901C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.927T>C PPE35_c.927T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.936C>T PPE35_c.936C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.945C>T PPE35_c.945C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.951T>C PPE35_c.951T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.954C>T PPE35_c.954C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.-95G>A PPE35_c.-95G>A 2 upstream_gene_variant 2170707 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 c.-96A>C PPE35_c.-96A>C 2 upstream_gene_variant 2170708 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1665 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1597 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 c.981C>A PPE35_c.981C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.23555131695149 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.2590571436125 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.99G>A PPE35_c.99G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide PPE35 c.-99T>C PPE35_c.-99T>C 2 upstream_gene_variant 2170711 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1604 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1536 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 6 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 deletion PPE35_deletion 2 feature_ablation (see "Genomic_coordinates" sheet) NA 0 0 0 1 4 4408 16818 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999762216145523 0.999391291831884 0.999935208223951 0.2 0.00505076337946806 0.716417936118089 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1559 1830 False False 0.95383393829401 0.0193637820130019 9.63941079069668 0 0 0.000836510060464794 0.999762216145523 0.999391291831884 0.999935208223951 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 4 3785 16042 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999750716689517 0.999361859844744 0.999932074644789 0.2 0.00505076337946806 0.716417936118089 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1494 1762 False False 0 0 0 0 0 0 0 1.05957727873183 0.0215096981131212 10.714411563858 0 0 0.000974130102511011 0.999750716689517 0.999361859844744 0.999932074644789 11 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 LoF PPE35_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 62 0 62 173 148 4236 16674 0.0392379224313903 0.0337005253799611 0.0453957560062082 0.991201997384377 0.989672857024135 0.99255745949665 0.538940809968847 0.482707922434744 0.594448587439936 0 0 0.0577626344292909 0 0 0.0246168015789842 0 0 0.241447574128986 1.43447110002247e-06 100 1830 True False 4.60116951228849 3.66286286524399 5.7851847751385 0 0 0.000870461215260477 0.991201997384377 0.989672857024135 0.99255745949665 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 62 0 62 171 147 3615 15899 0.0451664025356576 0.0387728047328795 0.0522733563883096 0.990838838339773 0.98924108471672 0.992254632584793 0.537735849056603 0.48123256607076 0.593529747775537 0 0 0.0577626344292909 0 0 0.0247821704895807 0 0 0.269776690247881 4.36974194256687e-06 99 1762 True False 0 0 0 0 0 0 0 5.1161148276738 4.06628876605173 6.44014553229875 0 0 0.001019916448067 0.990838838339773 0.98924108471672 0.992254632584793 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ala103Pro PPE35_p.Ala103Pro 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1538 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1473 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ala111Pro PPE35_p.Ala111Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 4409 16818 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1503 1830 False False 0 0 5.78028251232769 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 3786 16042 0 0 0.000973872929872615 0.999750716689517 0.999361859844744 0.999932074644789 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1439 1762 False False 0 0 0 0 0 0 0 0 0 6.42109836734015 0 0 0.000973872929872615 0.999750716689517 0.999361859844744 0.999932074644789 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ala132Ser PPE35_p.Ala132Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 7 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ala138Thr PPE35_p.Ala138Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ala139Gly PPE35_p.Ala139Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1636 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1567 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ala139Thr PPE35_p.Ala139Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 32 4409 16790 0 0 0.000836320411980403 0.998097729164189 0.997315612940588 0.99869849551898 0 0 0.108881160679352 NA NA NA 0 0 0.108881160679352 NA NA NA NA 1458 1830 False False 0 0 0.465549904466373 0 0 0.000836320411980403 0.998097729164189 0.997315612940588 0.99869849551898 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 32 3786 16014 0 0 0.000973872929872615 0.998005733516141 0.997185846734806 0.998635535618626 0 0 0.108881160679352 NA NA NA 0 0 0.108881160679352 NA NA NA NA 1393 1762 False False 0 0 0 0 0 0 0 0 0 0.517131841158514 0 0 0.000973872929872615 0.998005733516141 0.997185846734806 0.998635535618626 9 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ala160Ser PPE35_p.Ala160Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ala162Val PPE35_p.Ala162Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1467 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1402 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ala169Ser PPE35_p.Ala169Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ala17Thr PPE35_p.Ala17Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ala183_Pro196del PPE35_p.Ala183_Pro196del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ala183Glu PPE35_p.Ala183Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 11 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ala183Pro PPE35_p.Ala183Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1641 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1572 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ala183Thr PPE35_p.Ala183Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ala184fs PPE35_p.Ala184fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1621 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1552 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 10 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ala192Val PPE35_p.Ala192Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 4 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ala19Pro PPE35_p.Ala19Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 11 0 11 1 15 4408 16807 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999108310545714 0.998529719637006 0.999500845014484 0.0625 0.00158111172276588 0.302320738434531 0 0 0.284914152918154 0 0 0.218019360910534 0 0 1.51990003155982 0.135361969759911 315 1830 False False 0.254189352692075 0.00604027986577356 1.65312024234863 0 0 0.000836510060464794 0.999108310545714 0.998529719637006 0.999500845014484 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 0 11 1 15 3785 16031 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999065187585691 0.998458637051574 0.999476701181019 0.0625 0.00158111172276588 0.302320738434531 0 0 0.284914152918154 0 0 0.218019360910534 0 0 1.68840483880365 0.139258644018019 296 1762 False False 0 0 0 0 0 0 0 0.282360193747247 0.00670897970701436 1.8364726085417 0 0 0.000974130102511011 0.999065187585691 0.998458637051574 0.999476701181019 17 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ala204Thr PPE35_p.Ala204Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.23555131695149 1 1273 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 10.2590571436125 1 554.5 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ala210Thr PPE35_p.Ala210Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1474 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1409 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 6 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ala220Thr PPE35_p.Ala220Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1484 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1419 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ala262Thr PPE35_p.Ala262Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 5 4409 16817 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1591 1830 False False 0 0 4.16390782018879 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 3786 16041 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1524 1762 False False 0 0 0 0 0 0 0 0 0 4.62556638995023 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 3 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ala26Thr PPE35_p.Ala26Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1652 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1584 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ala26Val PPE35_p.Ala26Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ala27Thr PPE35_p.Ala27Thr 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1575 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1509 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ala280Thr PPE35_p.Ala280Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1628 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1559 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 3 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ala28Val PPE35_p.Ala28Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ala290Glu PPE35_p.Ala290Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ala324Val PPE35_p.Ala324Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 4409 16817 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 5.77993884793644 0.58676144625344 535 1830 False False 0 0 4.16390782018879 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 5 3786 16041 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 6.42069813886719 1 927 1762 False False 0 0 0 0 0 0 0 0 0 4.62556638995023 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ala35Pro PPE35_p.Ala35Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ala35Ser PPE35_p.Ala35Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ala39Thr PPE35_p.Ala39Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.23555131695149 1 1273 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 10.2590571436125 1 554.5 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ala421Thr PPE35_p.Ala421Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ala474Gly PPE35_p.Ala474Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 148.439276452294 1 1273 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 164.847877704944 1 927 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 3 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ala489_Pro514del PPE35_p.Ala489_Pro514del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 1 3 4408 16819 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999821662109142 0.999478910338162 0.999963220929399 0.25 0.00630946320970987 0.805879550316756 0 0 0.975 0 0 0.707598226178713 0 0 148.472873302081 1 1273 1830 False False 1.2718542044767 0.0242215257537785 15.8425197757275 0 0 0.000836510060464794 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 3 3785 16043 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999813037517138 0.999453714469566 0.999961442181588 0.25 0.00630946320970987 0.805879550316756 0 0 0.975 0 0 0.707598226178713 0 0 164.891318433929 1 927 1762 False False 0 0 0 0 0 0 0 1.41285777190664 0.0269058536042688 17.5998124179982 0 0 0.000974130102511011 0.999813037517138 0.999453714469566 0.999961442181588 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ala489_Pro540del PPE35_p.Ala489_Pro540del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 4408 16821 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 148.49048666616 1 897.5 1830 False False 3.81601633393829 0.0486026416232846 298.829108180248 0 0 0.000836510060464794 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 3785 16045 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 164.911820358037 1 927 1762 False False 0 0 0 0 0 0 0 4.23910171730515 0.0539892730999128 331.863925136224 0 0 0.000974130102511011 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ala515Thr PPE35_p.Ala515Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ala516_Ala541del PPE35_p.Ala516_Ala541del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 24 0 24 1 26 4408 16796 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.998454404945904 0.997736159451709 0.998990125307939 0.037037037037037 0.000937257091944708 0.189705617413044 0 0 0.142473597722525 0 0 0.132274604497754 0 0 0.633404153651295 0.00884648591083823 201 1830 False False 0.146551724137931 0.00357758344215746 0.892642783138967 0 0 0.000836510060464794 0.998454404945904 0.997736159451709 0.998990125307939 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 24 0 24 1 26 3785 16020 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.998379658481864 0.997626719235373 0.998941274586085 0.037037037037037 0.000937257091944708 0.189705617413044 0 0 0.142473597722525 0 0 0.132274604497754 0 0 0.703622743499401 0.00874175038218647 205 1762 False False 0 0 0 0 0 0 0 0.162788334518849 0.00397331187175207 0.991607037539867 0 0 0.000974130102511011 0.998379658481864 0.997626719235373 0.998941274586085 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ala516Thr PPE35_p.Ala516Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1605 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1537 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 25 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ala520Thr PPE35_p.Ala520Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ala575_Thr600del PPE35_p.Ala575_Thr600del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 148.448081147381 1 1273 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 164.858125974995 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ala66Val PPE35_p.Ala66Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1630 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1561 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ala67Val PPE35_p.Ala67Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1629 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1560 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ala680Val PPE35_p.Ala680Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1560 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1495 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ala685Val PPE35_p.Ala685Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1642 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1573 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 7 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Ala708_Phe714del PPE35_p.Ala708_Phe714del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1643 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1574 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Ala708Val PPE35_p.Ala708Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.23555131695149 1 1273 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 10.2590571436125 1 554.5 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ala73Glu PPE35_p.Ala73Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ala73Val PPE35_p.Ala73Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ala748Glu PPE35_p.Ala748Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Ala748Thr PPE35_p.Ala748Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 5 7 4404 16815 0.00113404400090723 0.000368320285107068 0.00264447958048867 0.999583878254666 0.99914281931165 0.999832681632407 0.416666666666666 0.15165222980843 0.723330314317894 0 0 0.521823750104981 0 0 0.409616397225003 0 0 4.16814077525367 0.590706542254316 552 1830 False False 2.72722849357726 0.68212109592114 9.98711669088145 0 0 0.000837269515297261 0.999583878254666 0.99914281931165 0.999832681632407 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 5 7 3781 16039 0.00132065504490227 0.000428947757354115 0.0030792549559865 0.999563754206656 0.999101374817905 0.99982458915172 0.416666666666666 0.15165222980843 0.723330314317894 0 0 0.521823750104981 0 0 0.409616397225003 0 0 4.63110784513287 0.590910841648742 518 1762 False False 0 0 0 0 0 0 0 3.029999622171 0.757835714605342 11.0940861285907 0 0 0.000975160152742905 0.999563754206656 0.999101374817905 0.99982458915172 6 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Ala78Gly PPE35_p.Ala78Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ala798Thr PPE35_p.Ala798Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1545 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1480 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 2 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Ala863Thr PPE35_p.Ala863Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1485 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1420 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ala883fs PPE35_p.Ala883fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1644 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1575 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 6 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Ala90Pro PPE35_p.Ala90Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 3 4408 16819 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999821662109142 0.999478910338162 0.999963220929399 0.25 0.00630946320970987 0.805879550316756 0 0 0.975 0 0 0.707598226178713 0 0 148.472873302081 1 1273 1830 False False 1.2718542044767 0.0242215257537785 15.8425197757275 0 0 0.000836510060464794 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 3 3785 16043 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999813037517138 0.999453714469566 0.999961442181588 0.25 0.00630946320970987 0.805879550316756 0 0 0.975 0 0 0.707598226178713 0 0 164.891318433929 1 927 1762 False False 0 0 0 0 0 0 0 1.41285777190664 0.0269058536042688 17.5998124179982 0 0 0.000974130102511011 0.999813037517138 0.999453714469566 0.999961442181588 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ala971Gly PPE35_p.Ala971Gly 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 18 4407 16804 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.998929972654856 0.998309420654136 0.99936571457723 0.1 0.0123485271702948 0.316982714019082 NA NA NA 0 0 0.185301968137852 NA NA NA NA 1596 1830 False False 0.423669414819857 0.0476606015331002 1.77072021666596 0 0 0.000836699794980095 0.998929972654856 0.998309420654136 0.99936571457723 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 18 3784 16028 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.998878225102829 0.998227689237744 0.999335033867569 0.1 0.0123485271702948 0.316982714019082 NA NA NA 0 0 0.185301968137852 NA NA NA NA 1529 1762 False False 0 0 0 0 0 0 0 0.470636598543575 0.0529416724194184 1.96714711428313 0 0 0.000974387411009493 0.998878225102829 0.998227689237744 0.999335033867569 25 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Asn11Asp PPE35_p.Asn11Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1481 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1416 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Asn129fs PPE35_p.Asn129fs 2 frameshift (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.23555131695149 1 1273 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 10.2590571436125 1 554.5 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 3 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Asn129Ser PPE35_p.Asn129Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Asn226_Gly238del PPE35_p.Asn226_Gly238del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1606 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1538 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Asn229Ser PPE35_p.Asn229Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1622 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1553 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Asn234Asp PPE35_p.Asn234Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1511 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1447 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Asn235Asp PPE35_p.Asn235Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Asn261Lys PPE35_p.Asn261Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Asn271Asp PPE35_p.Asn271Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1468 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1403 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Asn286Asp PPE35_p.Asn286Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 21 4408 16801 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.998751634763999 0.99809237079879 0.999227081372529 0.0454545454545454 0.00115014752657357 0.228444397667633 0 0 0.975 0 0 0.161097615219079 0 0 148.314352588089 1 1273 1830 False False 0.181499006136029 0.00439150444860987 1.12919573840867 0 0 0.000836510060464794 0.998751634763999 0.99809237079879 0.999227081372529 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 21 3785 16025 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.998691262619967 0.998000147941616 0.999189694123899 0.0454545454545454 0.00115014752657357 0.228444397667633 0 0 0.975 0 0 0.161097615219079 0 0 164.706800524343 1 927 1762 False False 0 0 0 0 0 0 0 0.201610366735862 0.00487744928186718 1.25441577840316 0 0 0.000974130102511011 0.998691262619967 0.998000147941616 0.999189694123899 31 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Asn286Thr PPE35_p.Asn286Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Asn299Asp PPE35_p.Asn299Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 148.448081147381 1 1273 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 164.858125974995 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Asn299Ile PPE35_p.Asn299Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1565 1830 False False Inf 1.57702975056642 Inf 0 0 0.000836889615584862 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1500 1762 False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf 0 0 0.000974644855475749 1 0.999770132403032 1 4 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Asn305Asp PPE35_p.Asn305Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1546 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1481 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Asn328Ser PPE35_p.Asn328Ser 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 18 4407 16804 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.998929972654856 0.998309420654136 0.99936571457723 0.1 0.0123485271702948 0.316982714019082 NA NA NA 0 0 0.185301968137852 NA NA NA NA 1645 1830 False False 0.423669414819857 0.0476606015331002 1.77072021666596 0 0 0.000836699794980095 0.998929972654856 0.998309420654136 0.99936571457723 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 18 3784 16028 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.998878225102829 0.998227689237744 0.999335033867569 0.1 0.0123485271702948 0.316982714019082 NA NA NA 0 0 0.185301968137852 NA NA NA NA 1576 1762 False False 0 0 0 0 0 0 0 0.470636598543575 0.0529416724194184 1.96714711428313 0 0 0.000974387411009493 0.998878225102829 0.998227689237744 0.999335033867569 31 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Asn338Asp PPE35_p.Asn338Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Asn346Asp PPE35_p.Asn346Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Asn383_Val384delinsIle PPE35_p.Asn383_Val384delinsIle 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Asn398Tyr PPE35_p.Asn398Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Asn403Ser PPE35_p.Asn403Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 10 0 10 27 10 4382 16812 0.00612383760489907 0.0040394118523243 0.00889744417883342 0.999405540363809 0.998907040193061 0.999714897863756 0.729729729729729 0.558806366424264 0.862097415586498 0 0 0.30849710781876 0 0 0.30849710781876 0 0 1.71237133628161 0.231554644174975 474 1830 False False 10.3588315837517 4.85416174522471 23.9921703660897 0 0 0.000841471290113881 0.999405540363809 0.998907040193061 0.999714897863756 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 8 3 3778 16043 0.00211304807184363 0.00091269178353604 0.00415927925423806 0.999813037517138 0.999453714469566 0.999961442181588 0.727272727272727 0.390257440427578 0.939782265827093 0 0 0.707598226178713 0 0 0.707598226178713 0 0 10.2807772303774 1 927 1762 False False 0 0 0 0 0 0 0 11.3238044820892 2.71592126399482 66.4138737417137 0 0 0.000975934121100684 0.999813037517138 0.999453714469566 0.999961442181588 35 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Asn418Thr PPE35_p.Asn418Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1550 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1485 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 3 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Asn423fs PPE35_p.Asn423fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1653 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1585 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Asn429Ser PPE35_p.Asn429Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1482 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1417 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Asn433Lys PPE35_p.Asn433Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1654 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1586 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Asn438fs PPE35_p.Asn438fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 1 17 4408 16805 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.998989418618475 0.998382452772912 0.999411192380357 0.0555555555555555 0.00140555616736942 0.272943599673368 NA NA NA 0 0 0.195064322969093 NA NA NA NA 1459 1830 False False 0.224258033521938 0.00536846248346029 1.43203726249083 0 0 0.000836510060464794 0.998989418618475 0.998382452772912 0.999411192380357 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 17 3785 16029 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.99894054593045 0.998304251550396 0.999382711664247 0.0555555555555555 0.00140555616736942 0.272943599673368 NA NA NA 0 0 0.195064322969093 NA NA NA NA 1394 1762 False False 0 0 0 0 0 0 0 0.249110264977853 0.00596269606976058 1.59084611373257 0 0 0.000974130102511011 0.99894054593045 0.998304251550396 0.999382711664247 25 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Asn439His PPE35_p.Asn439His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1515 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1451 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Asn495Asp PPE35_p.Asn495Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Asn495fs PPE35_p.Asn495fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 4 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Asn718Asp PPE35_p.Asn718Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1597 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1530 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Asn718Ser PPE35_p.Asn718Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1516 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1452 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 3 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Asn889Ser PPE35_p.Asn889Ser 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 2 4407 16820 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.999881108072762 0.999570588169705 0.999985601311719 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1666 1830 False False 3.8166553210801 0.276553001924986 52.6392074577436 0 0 0.000836699794980095 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 2 3784 16044 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999875358344758 0.999549824781286 0.999984904960856 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1598 1762 False False 0 0 0 0 0 0 0 4.2399577167019 0.307210542317908 58.5302826936734 0 0 0.000974387411009493 0.999875358344758 0.999549824781286 0.999984904960856 2 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Asn935Ser PPE35_p.Asn935Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Asn972Asp PPE35_p.Asn972Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1646 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1577 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Asp459His PPE35_p.Asp459His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1571 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1505 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Asp763Tyr PPE35_p.Asp763Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 3 4408 16819 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999821662109142 0.999478910338162 0.999963220929399 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.3260788325813 1 897.5 1830 False False 1.2718542044767 0.0242215257537785 15.8425197757275 0 0 0.000836510060464794 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 3 3785 16043 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999813037517138 0.999453714469566 0.999961442181588 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 22.5754213117106 1 927 1762 False False 0 0 0 0 0 0 0 1.41285777190664 0.0269058536042688 17.5998124179982 0 0 0.000974130102511011 0.999813037517138 0.999453714469566 0.999961442181588 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gln106Leu PPE35_p.Gln106Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1532 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1467 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gln306Lys PPE35_p.Gln306Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gln557* PPE35_p.Gln557* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1647 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1578 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gln619Arg PPE35_p.Gln619Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 2 8 4407 16814 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.999524432291047 0.999063158238902 0.999794661972981 0.2 0.0252107263268333 0.556095462307641 0 0 0.409616397225003 0 0 0.369416647552819 0 0 2.64818264682049 0.357428834601893 495 1830 False False 0.95382346267302 0.0986366048466683 4.78186960218232 0 0 0.000836699794980095 0.999524432291047 0.999063158238902 0.999794661972981 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 2 8 3784 16038 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999501433379035 0.999017862631239 0.999784730530787 0.2 0.0252107263268333 0.556095462307641 0 0 0.409616397225003 0 0 0.369416647552819 0 0 2.94194735065948 0.35966453574894 475 1762 False False 0 0 0 0 0 0 0 1.05959302325581 0.109559526952344 5.31216675784191 0 0 0.000974387411009493 0.999501433379035 0.999017862631239 0.999784730530787 10 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Gln619fs PPE35_p.Gln619fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 3 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gln675Lys PPE35_p.Gln675Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1576 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gln675Pro PPE35_p.Gln675Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1577 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1510 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Gln722Arg PPE35_p.Gln722Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Gln768His PPE35_p.Gln768His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1551 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1486 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gln813Glu PPE35_p.Gln813Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 0 8 4409 16814 0 0 0.000836320411980403 0.999524432291047 0.999063158238902 0.999794661972981 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 2.2350715489366 0.218829042398071 461.5 1830 False False 0 0 2.2350715489366 0 0 0.000836320411980403 0.999524432291047 0.999063158238902 0.999794661972981 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 0 8 3786 16038 0 0 0.000973872929872615 0.999501433379035 0.999017862631239 0.999784730530787 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 2.48286669292342 0.36696353836705 478 1762 False False 0 0 0 0 0 0 0 0 0 2.48286669292342 0 0 0.000973872929872615 0.999501433379035 0.999017862631239 0.999784730530787 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Gln838* PPE35_p.Gln838* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1483 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1418 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Gln85Arg PPE35_p.Gln85Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gln91Pro PPE35_p.Gln91Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1655 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1587 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Glu743Lys PPE35_p.Glu743Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Glu773Lys PPE35_p.Glu773Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Glu818Lys PPE35_p.Glu818Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 2 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Glu843Lys PPE35_p.Glu843Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Glu84Asp PPE35_p.Glu84Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Glu84Lys PPE35_p.Glu84Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly116fs PPE35_p.Gly116fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 12 4409 16810 0 0 0.000836320411980403 0.999286648436571 0.998754250286254 0.999631348241016 0 0 0.264648469397051 NA NA NA 0 0 0.264648469397051 NA NA NA NA 1592 1830 False False 0 0 1.37280707722974 0 0 0.000836320411980403 0.999286648436571 0.998754250286254 0.999631348241016 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 12 3786 16034 0 0 0.000973872929872615 0.999252150068553 0.998694021458847 0.999613517219799 0 0 0.264648469397051 NA NA NA 0 0 0.264648469397051 NA NA NA NA 1525 1762 False False 0 0 0 0 0 0 0 0 0 1.52501633506388 0 0 0.000973872929872615 0.999252150068553 0.998694021458847 0.999613517219799 3 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly127fs PPE35_p.Gly127fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1460 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1395 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly157Trp PPE35_p.Gly157Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1598 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1531 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly181_Ala192del PPE35_p.Gly181_Ala192del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1648 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1579 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly18Arg PPE35_p.Gly18Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1667 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1599 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly194Asp PPE35_p.Gly194Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 4409 16817 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.16390782018879 0.590722354627394 560.5 1830 False False 0 0 4.16390782018879 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 3786 16041 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.62556638995023 0.590888399193514 509 1762 False False 0 0 0 0 0 0 0 0 0 4.62556638995023 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly194Val PPE35_p.Gly194Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1517 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1453 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly208Ser PPE35_p.Gly208Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly223Ala PPE35_p.Gly223Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly223Arg PPE35_p.Gly223Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 148.448081147381 1 1273 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 164.858125974995 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly225Asp PPE35_p.Gly225Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 4409 16818 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 20.3202749232129 1 1273 1830 False False 0 0 5.78028251232769 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 4 3786 16042 0 0 0.000973872929872615 0.999750716689517 0.999361859844744 0.999932074644789 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 22.568060867927 1 927 1762 False False 0 0 0 0 0 0 0 0 0 6.42109836734015 0 0 0.000973872929872615 0.999750716689517 0.999361859844744 0.999932074644789 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly22Glu PPE35_p.Gly22Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 5 4409 16817 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 9.23445346324443 1 1273 1830 False False 0 0 4.16390782018879 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 5 3786 16041 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 10.2577787899531 1 927 1762 False False 0 0 0 0 0 0 0 0 0 4.62556638995023 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 7 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly233Ser PPE35_p.Gly233Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 3 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly238Ala PPE35_p.Gly238Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1637 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1568 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly238Trp PPE35_p.Gly238Trp 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1499 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1435 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 5 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly238Val PPE35_p.Gly238Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1523 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1458 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly258Asp PPE35_p.Gly258Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 102 504 4307 16318 0.0231344976185076 0.0189018437946347 0.0280139272303028 0.970039234335988 0.967350645993007 0.972563631229868 0.168316831683168 0.13937873068119 0.200529911761743 NA NA NA 0 0 0.00729248511307256 NA NA NA NA 1668 1830 False True 0.766763961214855 0.6119530613175 0.953047463103791 0 0 0.000856117987155997 0.970039234335988 0.967350645993007 0.972563631229868 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 87 470 3699 15576 0.0229793977812995 0.0184455117918336 0.0282686681103209 0.970709211018322 0.967982193229069 0.973263762054728 0.156193895870736 0.12703688720272 0.189052891689092 NA NA NA 0 0 0.00781795922739847 NA NA NA NA 1600 1762 False True 0 1 1 0 0 0 0 0.779458508049904 0.611026926242954 0.984686690041941 0 0 0.000996766875403067 0.970709211018322 0.967982193229069 0.973263762054728 743 5) Not assoc w R New NotAwR yes 5 +Pyrazinamide PPE35 p.Gly268Glu PPE35_p.Gly268Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly273Asp PPE35_p.Gly273Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1580 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1513 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly288Arg PPE35_p.Gly288Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1552 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1487 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly288Glu PPE35_p.Gly288Glu 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 1 4406 16821 0.000680426400544341 0.000140342268876931 0.00198719451371054 0.99994055403638 0.999668833292177 0.99999849495964 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 1539 1830 False False 11.4532455742169 0.919224933680734 599.12689591493 0 0 0.000836889615584862 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1474 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly293Val PPE35_p.Gly293Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly300Ser PPE35_p.Gly300Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1491 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1426 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly303Arg PPE35_p.Gly303Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1533 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1468 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly315Arg PPE35_p.Gly315Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly315Asp PPE35_p.Gly315Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly325Asp PPE35_p.Gly325Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 4409 16818 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1504 1830 False False 0 0 5.78028251232769 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 3786 16042 0 0 0.000973872929872615 0.999750716689517 0.999361859844744 0.999932074644789 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1440 1762 False False 0 0 0 0 0 0 0 0 0 6.42109836734015 0 0 0.000973872929872615 0.999750716689517 0.999361859844744 0.999932074644789 3 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly337Asp PPE35_p.Gly337Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1540 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1475 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly337Ser PPE35_p.Gly337Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly33Ala PPE35_p.Gly33Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 6 1 4403 16821 0.00136085280108868 0.000499567554195151 0.00295963286153356 0.99994055403638 0.999668833292177 0.99999849495964 0.857142857142857 0.421276802956804 0.996389703138099 0 0 0.975 0 0 0.975 0 0 148.658719205428 1 1273 1830 False False 22.9220985691573 2.7794245182276 1048.43039728317 0 0 0.000837459594522268 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1580 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly33Arg PPE35_p.Gly33Arg 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 10 4407 16812 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.999405540363809 0.998907040193061 0.999714897863756 0.166666666666666 0.0208625254600923 0.484137748685967 NA NA NA 0 0 0.30849710781876 NA NA NA NA 1610 1830 False False 0.762968005445881 0.0812546585328875 3.58230378497893 0 0 0.000836699794980095 0.999405540363809 0.998907040193061 0.999714897863756 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 10 3784 16036 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999376791723794 0.998854197426924 0.999701108243012 0.166666666666666 0.0208625254600923 0.484137748685967 NA NA NA 0 0 0.30849710781876 NA NA NA NA 1542 1762 False False 0 0 0 0 0 0 0 0.847568710359408 0.0902599413642468 3.97963463568136 0 0 0.000974387411009493 0.999376791723794 0.998854197426924 0.999701108243012 7 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly342Arg PPE35_p.Gly342Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1492 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1427 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly357fs PPE35_p.Gly357fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly357Ser PPE35_p.Gly357Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly370fs PPE35_p.Gly370fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly370Ser PPE35_p.Gly370Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1669 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1601 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly375Ala PPE35_p.Gly375Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1486 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1421 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly406fs PPE35_p.Gly406fs 2 frameshift (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 4408 16819 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999821662109142 0.999478910338162 0.999963220929399 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.23764632949317 1 1273 1830 False False 1.2718542044767 0.0242215257537785 15.8425197757275 0 0 0.000836510060464794 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 3 3785 16043 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999813037517138 0.999453714469566 0.999961442181588 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 10.2617671351504 1 927 1762 False False 0 0 0 0 0 0 0 1.41285777190664 0.0269058536042688 17.5998124179982 0 0 0.000974130102511011 0.999813037517138 0.999453714469566 0.999961442181588 7 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly406Val PPE35_p.Gly406Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1599 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1532 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly410Ser PPE35_p.Gly410Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly415Ala PPE35_p.Gly415Ala 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 14 4405 16808 0.000907235200725788 0.000247244623732042 0.00232123869101376 0.999167756509333 0.998604030697473 0.99954493241661 0.222222222222222 0.0640920477176664 0.47637276573648 NA NA NA 0 0 0.231635761650116 NA NA NA NA 1505 1830 False False 1.09018971947462 0.26116247442929 3.4735593506758 0 0 0.000837079522337697 0.999167756509333 0.998604030697473 0.99954493241661 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 14 3782 16032 0.00105652403592181 0.000287939890647285 0.00270289202199999 0.999127508413311 0.998536540247476 0.999522921242413 0.222222222222222 0.0640920477176664 0.47637276573648 NA NA NA 0 0 0.231635761650116 NA NA NA NA 1441 1762 False False 0 0 0 0 0 0 0 1.21115056281634 0.290125299162929 3.85939731739302 0 0 0.000974902436017582 0.999127508413311 0.998536540247476 0.999522921242413 45 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly425Ser PPE35_p.Gly425Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1518 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1454 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly430Val PPE35_p.Gly430Val 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1487 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1422 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly435Asp PPE35_p.Gly435Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly440Arg PPE35_p.Gly440Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 4409 16818 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.78028251232769 0.586765606596145 543.5 1830 False False 0 0 5.78028251232769 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 3786 16042 0 0 0.000973872929872615 0.999750716689517 0.999361859844744 0.999932074644789 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.42109836734015 1 554.5 1762 False False 0 0 0 0 0 0 0 0 0 6.42109836734015 0 0 0.000973872929872615 0.999750716689517 0.999361859844744 0.999932074644789 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly445Ser PPE35_p.Gly445Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly447Arg PPE35_p.Gly447Arg 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 4 4408 16818 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999762216145523 0.999391291831884 0.999935208223951 0.2 0.00505076337946806 0.716417936118089 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1541 1830 False False 0.95383393829401 0.0193637820130019 9.63941079069668 0 0 0.000836510060464794 0.999762216145523 0.999391291831884 0.999935208223951 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 4 3785 16042 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999750716689517 0.999361859844744 0.999932074644789 0.2 0.00505076337946806 0.716417936118089 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1476 1762 False False 0 0 0 0 0 0 0 1.05957727873183 0.0215096981131212 10.714411563858 0 0 0.000974130102511011 0.999750716689517 0.999361859844744 0.999932074644789 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly447fs PPE35_p.Gly447fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 17 4409 16805 0 0 0.000836320411980403 0.998989418618475 0.998382452772912 0.999411192380357 0 0 0.195064322969093 NA NA NA 0 0 0.195064322969093 NA NA NA NA 1631 1830 False False 0 0 0.92412091928757 0 0 0.000836320411980403 0.998989418618475 0.998382452772912 0.999411192380357 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 17 3786 16029 0 0 0.000973872929872615 0.99894054593045 0.998304251550396 0.999382711664247 0 0 0.195064322969093 NA NA NA 0 0 0.195064322969093 NA NA NA NA 1562 1762 False False 0 0 0 0 0 0 0 0 0 1.02659962523702 0 0 0.000973872929872615 0.99894054593045 0.998304251550396 0.999382711664247 3 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly449Ser PPE35_p.Gly449Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly499Asp PPE35_p.Gly499Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly499Ser PPE35_p.Gly499Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly51Glu PPE35_p.Gly51Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 16 319 4393 16503 0.00362894080290315 0.00207563231786599 0.00588650013813049 0.981036737605516 0.978860706599209 0.983044111983993 0.0477611940298507 0.0275426763680285 0.0764039769082149 NA NA NA 0 0 0.0114972806966447 NA NA NA NA 1581 1830 False True 0.188421733921235 0.10626346413842 0.311215495274725 0 0 0.000839365144326637 0.981036737605516 0.978860706599209 0.983044111983993 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 15 317 3771 15729 0.00396196513470681 0.002219125650155 0.0065262525797864 0.980244297644272 0.977970833381444 0.982341229302621 0.0451807228915662 0.0255045591725514 0.0734246791742244 NA NA NA 0 0 0.0115693975119062 NA NA NA NA 1514 1762 False True 1 1 1 0 0 0 0 0.197367925735753 0.109037479244041 0.331067812855077 0 0 0.000977744833911291 0.980244297644272 0.977970833381444 0.982341229302621 116 5) Not assoc w R New NotAwR yes 5 +Pyrazinamide PPE35 p.Gly525fs PPE35_p.Gly525fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly573Ser PPE35_p.Gly573Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1475 1830 False False Inf 1.57702975056642 Inf 0 0 0.000836889615584862 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1410 1762 False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf 0 0 0.000974644855475749 1 0.999770132403032 1 3 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly59Ala PPE35_p.Gly59Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1547 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1482 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly623Ser PPE35_p.Gly623Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1469 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1404 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Gly624Asp PPE35_p.Gly624Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 108 17 91 89 176 4320 16646 0.0201859832161487 0.0162415805922353 0.0247825830680946 0.989537510403043 0.987882576555882 0.991019731978184 0.335849056603773 0.279221910426318 0.396196175721959 0.157407407407407 0.0944530395156835 0.240020555084305 0.0880829015544041 0.0521504943577817 0.137283075056571 0.719836182336182 0.401487504498073 1.21856433989865 0.23418767211687 480 1830 False False 1.94851378367003 1.48933139343614 2.53431301072911 0.00391976020290523 0.00228501214888311 0.00626852130872654 0.989537510403043 0.987882576555882 0.991019731978184 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 108 17 91 87 175 3699 15871 0.0229793977812995 0.0184455117918336 0.0282686681103209 0.989093855166396 0.987363912763322 0.990642884008928 0.33206106870229 0.275317485238367 0.392655132470071 0.157407407407407 0.0944530395156835 0.240020555084305 0.0885416666666666 0.0524266612076111 0.137978401609138 0.801544224901889 0.44696729828377 1.35708543673838 0.460517740095279 485 1762 False False 0 0 0 0 0 0 0 2.13305063144479 1.62583072285852 2.78131586744944 0.00457481162540366 0.00266718641568701 0.00731464389670366 0.989093855166396 0.987363912763322 0.990642884008928 656 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Gly629Arg PPE35_p.Gly629Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 4409 16817 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 5.77993884793644 0.58676144625344 535 1830 False False 0 0 4.16390782018879 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 5 3786 16041 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 6.42069813886719 1 927 1762 False False 0 0 0 0 0 0 0 0 0 4.62556638995023 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Gly629Cys PPE35_p.Gly629Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1593 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1526 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly671Glu PPE35_p.Gly671Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1572 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1506 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly678Arg PPE35_p.Gly678Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Gly678Cys PPE35_p.Gly678Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Gly696* PPE35_p.Gly696* 2 stop_gained (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly697Ser PPE35_p.Gly697Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 4409 16816 0 0 0.000836320411980403 0.999643324218285 0.999223829869625 0.999869095386533 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.24030155506377 0.355876504746108 489.5 1830 False False 0 0 3.24030155506377 0 0 0.000836320411980403 0.999643324218285 0.999223829869625 0.999869095386533 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 3786 16041 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.62556638995023 0.590888399193514 509 1762 False False 0 0 0 0 0 0 0 0 0 4.62556638995023 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 1 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Gly727Trp PPE35_p.Gly727Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1553 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1488 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Gly757Val PPE35_p.Gly757Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly783Ala PPE35_p.Gly783Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Gly807Asp PPE35_p.Gly807Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1632 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1563 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly808Ala PPE35_p.Gly808Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 17 4409 16805 0 0 0.000836320411980403 0.998989418618475 0.998382452772912 0.999411192380357 0 0 0.195064322969093 NA NA NA 0 0 0.195064322969093 NA NA NA NA 1524 1830 False False 0 0 0.92412091928757 0 0 0.000836320411980403 0.998989418618475 0.998382452772912 0.999411192380357 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 17 3786 16029 0 0 0.000973872929872615 0.99894054593045 0.998304251550396 0.999382711664247 0 0 0.195064322969093 NA NA NA 0 0 0.195064322969093 NA NA NA NA 1459 1762 False False 0 0 0 0 0 0 0 0 0 1.02659962523702 0 0 0.000973872929872615 0.99894054593045 0.998304251550396 0.999382711664247 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Gly830Glu PPE35_p.Gly830Glu 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 18 4407 16804 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.998929972654856 0.998309420654136 0.99936571457723 0.1 0.0123485271702948 0.316982714019082 NA NA NA 0 0 0.185301968137852 NA NA NA NA 1506 1830 False False 0.423669414819857 0.0476606015331002 1.77072021666596 0 0 0.000836699794980095 0.998929972654856 0.998309420654136 0.99936571457723 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 18 3784 16028 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.998878225102829 0.998227689237744 0.999335033867569 0.1 0.0123485271702948 0.316982714019082 NA NA NA 0 0 0.185301968137852 NA NA NA NA 1442 1762 False False 0 0 0 0 0 0 0 0.470636598543575 0.0529416724194184 1.96714711428313 0 0 0.000974387411009493 0.998878225102829 0.998227689237744 0.999335033867569 30 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Gly877Asp PPE35_p.Gly877Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 378 50 328 123 571 4286 16251 0.0278974824223179 0.0232379865663964 0.0331955197432055 0.96605635477351 0.963208341494346 0.968741709799955 0.177233429394812 0.14952382416897 0.207718655660175 0.132275132275132 0.0997952540867651 0.170645948170802 0.0805152979066022 0.0603483041138271 0.104773518457696 0.577995003585126 0.41950941247678 0.781860569585326 0.000192180527615879 140 1830 True False 0.816764638341098 0.664648098679343 0.997197727395024 0.0115313653136531 0.00857058145127945 0.0151747175710018 0.96605635477351 0.963208341494346 0.968741709799955 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 376 50 326 123 569 3663 15477 0.0324881141045958 0.0270720361303857 0.0386405883538566 0.964539449083883 0.96156126839337 0.967347654865189 0.177745664739884 0.149962832094285 0.208307733355732 0.132978723404255 0.100335161399822 0.171533217017542 0.0807754442649434 0.0605452526610455 0.105107531347997 0.648040678715525 0.470174916067939 0.876995881465761 0.00346480925116024 171 1762 True False 0 0 0 0 0 0 0 0.913361516173467 0.742915363523477 1.11569884903654 0.0134661998384056 0.0100109482243834 0.0177153794307661 0.964539449083883 0.96156126839337 0.967347654865189 1859 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Gly884Trp PPE35_p.Gly884Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 6 4409 16816 0 0 0.000836320411980403 0.999643324218285 0.999223829869625 0.999869095386533 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1470 1830 False False 0 0 3.24030155506377 0 0 0.000836320411980403 0.999643324218285 0.999223829869625 0.999869095386533 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 3786 16040 0 0 0.000973872929872615 0.999626075034276 0.999186301793093 0.999862764161372 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1405 1762 False False 0 0 0 0 0 0 0 0 0 3.59982301180526 0 0 0.000973872929872615 0.999626075034276 0.999186301793093 0.999862764161372 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Gly913fs PPE35_p.Gly913fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Gly915Glu PPE35_p.Gly915Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1488 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1423 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 7 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly915* PPE35_p.Gly915* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 12 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Gly930Arg PPE35_p.Gly930Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Gly932Ser PPE35_p.Gly932Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 4409 16818 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.23500239012498 1 1273 1830 False False 0 0 5.78028251232769 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1428 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 6 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Gly937Ser PPE35_p.Gly937Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1566 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1501 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Gly938Arg PPE35_p.Gly938Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Gly942Ser PPE35_p.Gly942Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1670 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1602 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Gly949Ala PPE35_p.Gly949Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Gly949Ser PPE35_p.Gly949Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 7 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Gly974Ser PPE35_p.Gly974Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 0 10 4409 16812 0 0 0.000836320411980403 0.999405540363809 0.998907040193061 0.999714897863756 0 0 0.30849710781876 0 0 0.369416647552819 0 0 0.30849710781876 0 0 2.23480572765696 0.218817691246652 458.5 1830 False False 0 0 1.70188592764298 0 0 0.000836320411980403 0.999405540363809 0.998907040193061 0.999714897863756 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 0 10 3786 16036 0 0 0.000973872929872615 0.999376791723794 0.998854197426924 0.999701108243012 0 0 0.30849710781876 0 0 0.369416647552819 0 0 0.30849710781876 0 0 2.48255712205082 0.366969453374325 482 1762 False False 0 0 0 0 0 0 0 0 0 1.89058845367291 0 0 0.000973872929872615 0.999376791723794 0.998854197426924 0.999701108243012 9 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Gly979Ala PPE35_p.Gly979Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1623 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1554 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.His2Arg PPE35_p.His2Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1638 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1569 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.His356Tyr PPE35_p.His356Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ile10Ser PPE35_p.Ile10Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1493 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1429 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ile10Thr PPE35_p.Ile10Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ile122Met PPE35_p.Ile122Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1582 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1515 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ile133Val PPE35_p.Ile133Val 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1660 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1592 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ile15Met PPE35_p.Ile15Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 17 172 4392 16650 0.00385574960308459 0.00224767150840848 0.00616627368860949 0.98977529425752 0.988137666567824 0.991240077509028 0.0899470899470899 0.0532730004485516 0.140107253323095 NA NA NA 0 0 0.0212186226251259 NA NA NA NA 1554 1830 False True 0.374690240182996 0.213067233185121 0.618557197985316 0 0 0.000839556176361836 0.98977529425752 0.988137666567824 0.991240077509028 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 17 171 3769 15875 0.00449022715266772 0.00261783253916465 0.00717958501762183 0.989343138476878 0.987631376919501 0.990873843277967 0.0904255319148936 0.0535612207177814 0.14083152989118 NA NA NA 0 0 0.0213413745665028 NA NA NA NA 1489 1762 False True 0 1 1 0 0 0 0 0.418736103547096 0.238066312381518 0.691496094395364 0 0 0.000978263415196473 0.989343138476878 0.987631376919501 0.990873843277967 415 5) Not assoc w R New NotAwR yes 5 +Pyrazinamide PPE35 p.Ile227_Asn229del PPE35_p.Ile227_Asn229del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 3 1 2 2 2 4407 16820 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.999881108072762 0.999570588169705 0.999985601311719 0.5 0.067585986488543 0.932414013511457 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 1.90832766054005 0.0323387668486046 36.671823741687 0.502530085826874 520.5 1830 False False 3.8166553210801 0.276553001924986 52.6392074577436 0.000226860254083484 5.74358785768897e-06 0.0012633291757201 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 3785 16044 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999875358344758 0.999549824781286 0.999984904960856 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5768265057825 1 927 1762 False False 0 0 0 0 0 0 0 2.11941875825627 0.0359146288488272 40.7195918479678 0 0 0.000974130102511011 0.999875358344758 0.999549824781286 0.999984904960856 9 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ile257Val PPE35_p.Ile257Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ile307Met PPE35_p.Ile307Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1611 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1543 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ile417Val PPE35_p.Ile417Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1561 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1496 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ile470fs PPE35_p.Ile470fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ile522Val PPE35_p.Ile522Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 7 4409 16815 0 0 0.000836320411980403 0.999583878254666 0.99914281931165 0.999832681632407 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 3.24010868261878 0.355870765149436 486.5 1830 False False 0 0 2.64713852578052 0 0 0.000836320411980403 0.999583878254666 0.99914281931165 0.999832681632407 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 7 3786 16039 0 0 0.000973872929872615 0.999563754206656 0.999101374817905 0.99982458915172 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 3.59959860917618 0.602789601856331 525.5 1762 False False 0 0 0 0 0 0 0 0 0 2.94057641353956 0 0 0.000973872929872615 0.999563754206656 0.999101374817905 0.99982458915172 4 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ile539Val PPE35_p.Ile539Val 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 36 1 4373 16821 0.00816511680653209 0.00572511220853846 0.011286206671795 0.99994055403638 0.999668833292177 0.99999849495964 0.972972972972973 0.858396904388842 0.999315968975305 NA NA NA 0 0 0.975 NA NA NA NA 1671 1830 False False 138.476103361536 23.3150769207094 5432.58039290235 0 0 0.000843202378114448 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1603 1762 False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf 0 0 0.000974644855475749 1 0.999770132403032 1 101 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ile548Val PPE35_p.Ile548Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.23555131695149 1 1273 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 10.2590571436125 1 554.5 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ile610Val PPE35_p.Ile610Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1639 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1570 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 9 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ile676Val PPE35_p.Ile676Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 7 4409 16815 0 0 0.000836320411980403 0.999583878254666 0.99914281931165 0.999832681632407 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 3.24010868261878 0.355870765149436 486.5 1830 False False 0 0 2.64713852578052 0 0 0.000836320411980403 0.999583878254666 0.99914281931165 0.999832681632407 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 7 3786 16039 0 0 0.000973872929872615 0.999563754206656 0.999101374817905 0.99982458915172 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 3.59959860917618 0.602789601856331 525.5 1762 False False 0 0 0 0 0 0 0 0 0 2.94057641353956 0 0 0.000973872929872615 0.999563754206656 0.999101374817905 0.99982458915172 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Ile699Phe PPE35_p.Ile699Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1471 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1406 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ile729fs PPE35_p.Ile729fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1507 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1443 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ile751Val PPE35_p.Ile751Val 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 2 4407 16820 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.999881108072762 0.999570588169705 0.999985601311719 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1583 1830 False False 3.8166553210801 0.276553001924986 52.6392074577436 0 0 0.000836699794980095 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 2 3784 16044 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999875358344758 0.999549824781286 0.999984904960856 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1516 1762 False False 0 0 0 0 0 0 0 4.2399577167019 0.307210542317908 58.5302826936734 0 0 0.000974387411009493 0.999875358344758 0.999549824781286 0.999984904960856 1 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Ile794Thr PPE35_p.Ile794Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ile841Ser PPE35_p.Ile841Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1525 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1460 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Ile841Val PPE35_p.Ile841Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Ile950Thr PPE35_p.Ile950Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Ile973Thr PPE35_p.Ile973Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ile973Val PPE35_p.Ile973Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 3 4408 16819 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999821662109142 0.999478910338162 0.999963220929399 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.3260788325813 1 897.5 1830 False False 1.2718542044767 0.0242215257537785 15.8425197757275 0 0 0.000836510060464794 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 22.56946568665 1 927 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 7 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Leu102Ala PPE35_p.Leu102Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 9 4409 16813 0 0 0.000836320411980403 0.999464986327428 0.998984621445092 0.999755329427402 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1494 1830 False False 0 0 1.9328143827158 0 0 0.000836320411980403 0.999464986327428 0.998984621445092 0.999755329427402 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 9 3786 16037 0 0 0.000973872929872615 0.999439112551414 0.998935529133907 0.999743495490327 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1430 1762 False False 0 0 0 0 0 0 0 0 0 2.14715011586227 0 0 0.000973872929872615 0.999439112551414 0.998935529133907 0.999743495490327 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Leu120Arg PPE35_p.Leu120Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.23555131695149 1 1273 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 10.2590571436125 1 554.5 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 5 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Leu125fs PPE35_p.Leu125fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1461 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1396 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Leu146_Asp147insVal PPE35_p.Leu146_Asp147insVal 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 10 0 10 0 10 4409 16812 0 0 0.000836320411980403 0.999405540363809 0.998907040193061 0.999714897863756 0 0 0.30849710781876 0 0 0.30849710781876 0 0 0.30849710781876 0 0 1.70188592764298 0.232177773145798 476.5 1830 False False 0 0 1.70188592764298 0 0 0.000836320411980403 0.999405540363809 0.998907040193061 0.999714897863756 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 0 10 3786 16036 0 0 0.000973872929872615 0.999376791723794 0.998854197426924 0.999701108243012 0 0 0.30849710781876 0 0 0.30849710781876 0 0 0.30849710781876 0 0 1.89058845367291 0.225511848474235 452.5 1762 False False 0 0 0 0 0 0 0 0 0 1.89058845367291 0 0 0.000973872929872615 0.999376791723794 0.998854197426924 0.999701108243012 6 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Leu14Ser PPE35_p.Leu14Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Leu165Val PPE35_p.Leu165Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Leu170fs PPE35_p.Leu170fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Leu189Phe PPE35_p.Leu189Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1534 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1469 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Leu207His PPE35_p.Leu207His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1535 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1470 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Leu207Val PPE35_p.Leu207Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 9 0 9 1 11 4408 16811 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99934609440019 0.998830284178405 0.999673528922672 0.0833333333333333 0.00210759323186022 0.384796165150944 0 0 0.336267116879942 0 0 0.284914152918154 0 0 1.93302306845128 0.219086030829033 465 1830 False False 0.34670433921795 0.00805649680695742 2.38673588737458 0 0 0.000836510060464794 0.99934609440019 0.998830284178405 0.999673528922672 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 1 10 3785 16036 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999376791723794 0.998854197426924 0.999701108243012 0.0909090909090909 0.00229897221381426 0.412779916988382 0 0 0.336267116879942 0 0 0.30849710781876 0 0 2.14758391389785 0.222601755717988 449 1762 False False 0 0 0 0 0 0 0 0.423672391017173 0.00976342393362646 2.97980157498564 0 0 0.000974130102511011 0.999376791723794 0.998854197426924 0.999701108243012 6 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Leu217_Asn226del PPE35_p.Leu217_Asn226del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Leu232Pro PPE35_p.Leu232Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Leu269_Gly288del PPE35_p.Leu269_Gly288del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 4408 16821 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 148.49048666616 1 897.5 1830 False False 3.81601633393829 0.0486026416232846 298.829108180248 0 0 0.000836510060464794 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 3785 16045 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 164.911820358037 1 927 1762 False False 0 0 0 0 0 0 0 4.23910171730515 0.0539892730999128 331.863925136224 0 0 0.000974130102511011 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Leu269Ile PPE35_p.Leu269Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1600 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1533 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Leu275fs PPE35_p.Leu275fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1656 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1588 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Leu362Pro PPE35_p.Leu362Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 8 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Leu451Arg PPE35_p.Leu451Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Leu460Trp PPE35_p.Leu460Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Leu477Arg PPE35_p.Leu477Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1633 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1564 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Leu482Ser PPE35_p.Leu482Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1567 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1502 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Leu503Phe PPE35_p.Leu503Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1526 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1461 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Leu555Phe PPE35_p.Leu555Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Leu584Arg PPE35_p.Leu584Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Leu641Arg PPE35_p.Leu641Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1508 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1444 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Leu654Phe PPE35_p.Leu654Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 23 0 23 0 24 4409 16798 0 0 0.000836320411980403 0.998573296873142 0.997877917781838 0.999085677166006 0 0 0.142473597722525 0 0 0.148185128915224 0 0 0.142473597722525 0 0 0.663140144606112 0.0081161806433926 200 1830 False False 0 0 0.633335850709692 0 0 0.000836320411980403 0.998573296873142 0.997877917781838 0.999085677166006 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 23 0 23 0 24 3786 16022 0 0 0.000973872929872615 0.998504300137105 0.997775329312221 0.999041449122186 0 0 0.142473597722525 0 0 0.148185128915224 0 0 0.142473597722525 0 0 0.73661779366718 0.0139751749127824 207 1762 False False 0 0 0 0 0 0 0 0 0 0.70352464582317 0 0 0.000973872929872615 0.998504300137105 0.997775329312221 0.999041449122186 14 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Leu654Ser PPE35_p.Leu654Ser 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1476 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1411 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Leu716_Pro717del PPE35_p.Leu716_Pro717del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Leu749Phe PPE35_p.Leu749Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1584 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1517 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Leu759Ser PPE35_p.Leu759Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Leu781Met PPE35_p.Leu781Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Leu789Arg PPE35_p.Leu789Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.23555131695149 1 1273 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 10.2590571436125 1 554.5 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 10 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Leu789fs PPE35_p.Leu789fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1578 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1511 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Leu856fs PPE35_p.Leu856fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1562 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1497 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Leu864Arg PPE35_p.Leu864Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 2 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Leu896Ser PPE35_p.Leu896Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2658 7191 1751 9631 0.602857790882286 0.588237095078675 0.617342087085497 0.572524075615265 0.565006472486901 0.580016593243253 0.269875114224794 0.261126802447376 0.278759695056881 NA NA NA 0 0 0.000512854046010663 NA NA NA NA NA NA False True 2.03306341188431 1.89908917297738 2.176592052834 0 0 0.0021045096801413 0.572524075615265 0.565006472486901 0.580016593243253 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 2563 7025 1223 9021 0.676967776016904 0.661807557293085 0.691854355169908 0.562196185965349 0.554478089610221 0.569891726375673 0.267313308302044 0.258474540998481 0.276293629609472 NA NA NA 0 0 0.000524969550843771 NA NA NA NA NA NA False True 0 1 1 0 0 1 0 2.69110413399173 2.49541027326893 2.90288078696337 0 0 0.00301171033803149 0.562196185965349 0.554478089610221 0.569891726375673 17750 Not assoc w R 5) Not assoc w R No change yes 1 +Pyrazinamide PPE35 p.Leu939fs PPE35_p.Leu939fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1649 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1581 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 3 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Leu959Arg PPE35_p.Leu959Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 3 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Leu977Arg PPE35_p.Leu977Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1657 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1589 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Leu980Pro PPE35_p.Leu980Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1612 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Met104Ile PPE35_p.Met104Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Met143Thr PPE35_p.Met143Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1500 1830 False False Inf 0.716637886286628 Inf 0 0 0.000836699794980095 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1436 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0 0 0.000974387411009493 1 0.999770132403032 1 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Met65Val PPE35_p.Met65Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1477 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1412 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Phe126fs PPE35_p.Phe126fs 2 frameshift (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.23555131695149 1 1273 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 10.2590571436125 1 554.5 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Phe16del PPE35_p.Phe16del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1568 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Phe245Cys PPE35_p.Phe245Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 309 14 295 69 354 4340 16468 0.0156498072125198 0.0121963516682731 0.0197645768553033 0.978956128878849 0.976672778359167 0.981071706423659 0.163120567375886 0.129190104193937 0.201845780390025 0.0453074433656957 0.0249881387991688 0.0748504286591125 0.0380434782608695 0.0209520766338891 0.0630072248892255 0.180076544559868 0.0971495849430525 0.307437896158845 7.27336102188726e-16 35 1830 True False 0.739600093728032 0.561703945287625 0.961894337621737 0.00321543408360128 0.00175898831027698 0.00538907270276467 0.978956128878849 0.976672778359167 0.981071706423659 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 309 14 295 69 354 3717 15692 0.0182250396196513 0.0142071356844149 0.0230089812674996 0.97793842702231 0.975546031863601 0.980155308393298 0.163120567375886 0.129190104193937 0.201845780390025 0.0453074433656957 0.0249881387991688 0.0748504286591125 0.0380434782608695 0.0209520766338891 0.0630072248892255 0.200351112387883 0.108059099361938 0.342075683640214 1.22788025454002e-13 39 1762 True False 0 0 0 0 0 0 0 0.822870640164521 0.624776705875396 1.07055949898006 0.00375234521575985 0.00205291392644045 0.00628779094187641 0.97793842702231 0.975546031863601 0.980155308393298 911 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Phe279Leu PPE35_p.Phe279Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 19 1 18 3 18 4406 16804 0.000680426400544341 0.000140342268876931 0.00198719451371054 0.998929972654856 0.998309420654136 0.99936571457723 0.142857142857142 0.0304889676215155 0.363423987016981 0.0526315789473684 0.00133162880417942 0.260280654195214 0.0526315789473684 0.00133162880417942 0.260280654195214 0.211882786099762 0.0050879366057594 1.34276177802771 0.151744799525232 323 1830 False False 0.635648358299288 0.119886535656388 2.17882691641306 0.00022691173133651 5.74489114141023e-06 0.00126361569125499 0.998929972654856 0.998309420654136 0.99936571457723 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 19 1 18 3 18 3783 16028 0.000792393026941363 0.000163440311798119 0.00231394549068866 0.998878225102829 0.998227689237744 0.999335033867569 0.142857142857142 0.0304889676215155 0.363423987016981 0.0526315789473684 0.00133162880417942 0.260280654195214 0.0526315789473684 0.00133162880417942 0.260280654195214 0.23538050342174 0.00565149746278253 1.49181450582917 0.152233294628913 303 1762 False False 0 0 0 0 0 0 0 0.706141510265221 0.133179613736811 2.42069909056692 0.000264270613107822 6.69073025551889e-06 0.00147153246904254 0.998878225102829 0.998227689237744 0.999335033867569 40 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Phe331Val PPE35_p.Phe331Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Phe412Leu PPE35_p.Phe412Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1563 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1498 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Phe45fs PPE35_p.Phe45fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Phe475Ile PPE35_p.Phe475Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Phe657Leu PPE35_p.Phe657Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 12 0 12 0 12 4409 16810 0 0 0.000836320411980403 0.999286648436571 0.998754250286254 0.999631348241016 0 0 0.264648469397051 0 0 0.264648469397051 0 0 0.264648469397051 0 0 1.37280707722974 0.144295971508092 320.5 1830 False False 0 0 1.37280707722974 0 0 0.000836320411980403 0.999286648436571 0.998754250286254 0.999631348241016 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 12 0 12 0 12 3786 16034 0 0 0.000973872929872615 0.999252150068553 0.998694021458847 0.999613517219799 0 0 0.264648469397051 0 0 0.264648469397051 0 0 0.264648469397051 0 0 1.52501633506388 0.139670104028204 299 1762 False False 0 0 0 0 0 0 0 0 0 1.52501633506388 0 0 0.000973872929872615 0.999252150068553 0.998694021458847 0.999613517219799 7 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Phe657Ser PPE35_p.Phe657Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 2 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Phe686Leu PPE35_p.Phe686Leu 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1613 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1544 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 1 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Phe704Leu PPE35_p.Phe704Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 31 0 31 1 31 4408 16791 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.998157175127808 0.997385268251665 0.998747557085331 0.03125 0.000790868597952557 0.162170994181511 0 0 0.11218874692237 0 0 0.11218874692237 0 0 0.481612965624011 0.00128383438640437 161 1830 True False 0.122877758913412 0.00301812489649231 0.737803764877926 0 0 0.000836510060464794 0.998157175127808 0.997385268251665 0.998747557085331 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 28 0 28 1 28 3785 16018 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.998255016826623 0.997478993411849 0.998840167868832 0.0344827586206896 0.000872646883579922 0.177644295488722 0 0 0.123436118500263 0 0 0.123436118500263 0 0 0.596299072668128 0.00594462957883702 177 1762 False False 0 0 0 0 0 0 0 0.151141724853746 0.00369899548832063 0.914853656509928 0 0 0.000974130102511011 0.998255016826623 0.997478993411849 0.998840167868832 25 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Phe714Leu PPE35_p.Phe714Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Phe714Ser PPE35_p.Phe714Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1614 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1545 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Phe734Cys PPE35_p.Phe734Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 4409 16817 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 5.77993884793644 0.58676144625344 535 1830 False False 0 0 4.16390782018879 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 5 3786 16041 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 6.42069813886719 1 927 1762 False False 0 0 0 0 0 0 0 0 0 4.62556638995023 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 3 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Phe784Leu PPE35_p.Phe784Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 11 0 11 0 11 4409 16811 0 0 0.000836320411980403 0.99934609440019 0.998830284178405 0.999673528922672 0 0 0.284914152918154 0 0 0.284914152918154 0 0 0.284914152918154 0 0 1.51991683293768 0.135362010704541 316.5 1830 False False 0 0 1.51991683293768 0 0 0.000836320411980403 0.99934609440019 0.998830284178405 0.999673528922672 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 0 11 0 11 3786 16035 0 0 0.000973872929872615 0.999314470896173 0.998773730902855 0.999657738248111 0 0 0.284914152918154 0 0 0.284914152918154 0 0 0.284914152918154 0 0 1.68837982812114 0.139257612313174 294.5 1762 False False 0 0 0 0 0 0 0 0 0 1.68837982812114 0 0 0.000973872929872615 0.999314470896173 0.998773730902855 0.999657738248111 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Phe809Ile PPE35_p.Phe809Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1462 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1397 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Phe824Leu PPE35_p.Phe824Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1624 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1555 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Phe859Ser PPE35_p.Phe859Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 4408 16821 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 148.49048666616 1 897.5 1830 False False 3.81601633393829 0.0486026416232846 298.829108180248 0 0 0.000836510060464794 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Phe982Val PPE35_p.Phe982Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1569 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1503 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Pro107Ser PPE35_p.Pro107Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 148.439276452294 1 1273 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 164.847877704944 1 927 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Pro182fs PPE35_p.Pro182fs 2 frameshift (see "Genomic_coordinates" sheet) 1 10 0 10 0 11 4409 16811 0 0 0.000836320411980403 0.99934609440019 0.998830284178405 0.999673528922672 0 0 0.284914152918154 0 0 0.30849710781876 0 0 0.284914152918154 0 0 1.70178474848402 0.232183942229341 478 1830 False False 0 0 1.51991683293768 0 0 0.000836320411980403 0.99934609440019 0.998830284178405 0.999673528922672 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 0 11 3786 16035 0 0 0.000973872929872615 0.999314470896173 0.998773730902855 0.999657738248111 0 0 0.284914152918154 0 0 0.30849710781876 0 0 0.284914152918154 0 0 1.89047057007778 0.225513325584291 454 1762 False False 0 0 0 0 0 0 0 0 0 1.68837982812114 0 0 0.000973872929872615 0.999314470896173 0.998773730902855 0.999657738248111 4 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Pro23Ser PPE35_p.Pro23Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1478 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1413 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Pro354Leu PPE35_p.Pro354Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1479 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1414 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Pro354Thr PPE35_p.Pro354Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Pro473Arg PPE35_p.Pro473Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1555 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1490 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Pro473Thr PPE35_p.Pro473Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1542 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1477 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 3 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Pro483Leu PPE35_p.Pro483Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1489 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1424 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Pro488Leu PPE35_p.Pro488Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1564 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1499 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Pro504Arg PPE35_p.Pro504Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1536 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1471 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Pro561Ser PPE35_p.Pro561Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1615 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1546 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Pro566Leu PPE35_p.Pro566Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 3 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Pro587Leu PPE35_p.Pro587Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 16 0 16 0 17 4409 16805 0 0 0.000836320411980403 0.998989418618475 0.998382452772912 0.999411192380357 0 0 0.195064322969093 0 0 0.205907214207822 0 0 0.195064322969093 0 0 0.988817988040368 0.0563619424918092 290 1830 False False 0 0 0.92412091928757 0 0 0.000836320411980403 0.998989418618475 0.998382452772912 0.999411192380357 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 16 0 16 0 17 3786 16029 0 0 0.000973872929872615 0.99894054593045 0.998304251550396 0.999382711664247 0 0 0.195064322969093 0 0 0.205907214207822 0 0 0.195064322969093 0 0 1.09842738572388 0.0545517987929135 273 1762 False False 0 0 0 0 0 0 0 0 0 1.02659962523702 0 0 0.000973872929872615 0.99894054593045 0.998304251550396 0.999382711664247 12 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Pro593_Pro597del PPE35_p.Pro593_Pro597del 2 inframe_deletion (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1672 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1604 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Pro593Leu PPE35_p.Pro593Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 4408 16821 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 148.49048666616 1 897.5 1830 False False 3.81601633393829 0.0486026416232846 298.829108180248 0 0 0.000836510060464794 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 3785 16045 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 164.911820358037 1 927 1762 False False 0 0 0 0 0 0 0 4.23910171730515 0.0539892730999128 331.863925136224 0 0 0.000974130102511011 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Pro608Ser PPE35_p.Pro608Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1501 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1437 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 1 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Pro613Thr PPE35_p.Pro613Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1527 1830 False False Inf 0.716637886286628 Inf 0 0 0.000836699794980095 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Pro642Ser PPE35_p.Pro642Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Pro670Leu PPE35_p.Pro670Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 10 286 4399 16536 0.00226808800181447 0.00108815543692413 0.00416712622349087 0.982998454404946 0.980929493197507 0.984897899155501 0.0337837837837837 0.0163172869354178 0.0612504471192012 NA NA NA 0 0 0.0128153548668553 NA NA NA NA NA NA False True 0.13143483023001 0.0622757021169166 0.245578216916125 0 0 0.000838220775252836 0.982998454404946 0.980929493197507 0.984897899155501 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 10 286 3776 15760 0.00264131008980454 0.00126731492930415 0.00485208155788738 0.982176243300511 0.980008243369042 0.984166830610232 0.0337837837837837 0.0163172869354178 0.0612504471192012 NA NA NA 0 0 0.0128153548668553 NA NA NA NA NA NA False True 1 1 1 0 0 1 0 0.145934573900675 0.0691410235629666 0.272719792027394 0 0 0.000976450782906915 0.982176243300511 0.980008243369042 0.984166830610232 563 Not assoc w R 5) Not assoc w R No change yes 1 +Pyrazinamide PPE35 p.Pro674fs PPE35_p.Pro674fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 148.439276452294 1 1273 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 164.858125974995 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 2 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Pro683Leu PPE35_p.Pro683Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 12 4407 16810 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.999286648436571 0.998754250286254 0.999631348241016 0.142857142857142 0.0177945154831915 0.428129160909698 NA NA NA 0 0 0.264648469397051 NA NA NA NA 1495 1830 False False 0.635731033961122 0.069080499493271 2.85729378651737 0 0 0.000836699794980095 0.999286648436571 0.998754250286254 0.999631348241016 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 12 3784 16034 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999252150068553 0.998694021458847 0.999613517219799 0.142857142857142 0.0177945154831915 0.428129160909698 NA NA NA 0 0 0.264648469397051 NA NA NA NA 1431 1762 False False 0 0 0 0 0 0 0 0.70621916842847 0.0767360307983807 3.17429704034148 0 0 0.000974387411009493 0.999252150068553 0.998694021458847 0.999613517219799 10 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Pro684fs PPE35_p.Pro684fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1658 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1590 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Pro713Leu PPE35_p.Pro713Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 7 4409 16815 0 0 0.000836320411980403 0.999583878254666 0.99914281931165 0.999832681632407 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 2.64713852578052 0.357432235618625 497.5 1830 False False 0 0 2.64713852578052 0 0 0.000836320411980403 0.999583878254666 0.99914281931165 0.999832681632407 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 7 3786 16039 0 0 0.000973872929872615 0.999563754206656 0.999101374817905 0.99982458915172 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 2.94057641353956 0.359641186358848 473.5 1762 False False 0 0 0 0 0 0 0 0 0 2.94057641353956 0 0 0.000973872929872615 0.999563754206656 0.999101374817905 0.99982458915172 4 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Pro717Leu PPE35_p.Pro717Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1528 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1462 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Pro71Gln PPE35_p.Pro71Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Pro71Leu PPE35_p.Pro71Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Pro737Leu PPE35_p.Pro737Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Pro747_Thr796del PPE35_p.Pro747_Thr796del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1463 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1398 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Pro772Leu PPE35_p.Pro772Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 3 4 4406 16818 0.000680426400544341 0.000140342268876931 0.00198719451371054 0.999762216145523 0.999391291831884 0.999935208223951 0.428571428571428 0.0989882784425078 0.815948432359917 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.24128990559238 1 1273 1830 False False 2.86280072628234 0.41917700195722 16.9258510172791 0 0 0.000836889615584862 0.999762216145523 0.999391291831884 0.999935208223951 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1463 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0 0 0.000974387411009493 1 0.999770132403032 1 13 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Pro803Gln PPE35_p.Pro803Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 16 4409 16806 0 0 0.000836320411980403 0.999048864582094 0.998455873997109 0.999456249287664 0 0 0.205907214207822 NA NA NA 0 0 0.205907214207822 NA NA NA NA 1616 1830 False False 0 0 0.988876825211935 0 0 0.000836320411980403 0.999048864582094 0.998455873997109 0.999456249287664 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 14 3786 16032 0 0 0.000973872929872615 0.999127508413311 0.998536540247476 0.999522921242413 0 0 0.231635761650116 NA NA NA 0 0 0.231635761650116 NA NA NA NA 1547 1762 False False 0 0 0 0 0 0 0 0 0 1.27728416483145 0 0 0.000973872929872615 0.999127508413311 0.998536540247476 0.999522921242413 8 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Pro803Ser PPE35_p.Pro803Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Pro812fs PPE35_p.Pro812fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1601 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1534 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Pro822Ser PPE35_p.Pro822Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 98 938 4311 15884 0.0222272624177818 0.018081106663208 0.0270218302222994 0.944239686125312 0.940664951696277 0.947659835834469 0.0945945945945946 0.077463140558734 0.114068046244692 NA NA NA 0 0 0.00392498434114782 NA NA NA NA NA NA False True 0.384950681526258 0.308553127452542 0.475821982710453 0 0 0.000855323970219269 0.944239686125312 0.940664951696277 0.947659835834469 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 92 920 3694 15126 0.0243000528262017 0.0196331664296816 0.0297195394872891 0.942664838589056 0.93895556426732 0.946212608475834 0.0909090909090909 0.0739136159787576 0.110326249945846 NA NA NA 0 0 0.00400162366096429 NA NA NA NA NA NA False True 0 1 1 0 0 1 0 0.409474824038982 0.325820631972839 0.509475199192973 0 0 0.000998115371972856 0.942664838589056 0.93895556426732 0.946212608475834 1162 Not assoc w R 5) Not assoc w R No change yes 1 +Pyrazinamide PPE35 p.Pro823Leu PPE35_p.Pro823Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 4409 16818 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.78028251232769 0.586765606596145 543.5 1830 False False 0 0 5.78028251232769 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 10.2590571436125 1 554.5 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 1 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Pro823Thr PPE35_p.Pro823Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Pro828Arg PPE35_p.Pro828Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1625 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1556 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Pro837fs PPE35_p.Pro837fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 148.448081147381 1 1273 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 164.858125974995 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Pro853Leu PPE35_p.Pro853Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1659 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1591 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Pro872Gln PPE35_p.Pro872Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Pro885Leu PPE35_p.Pro885Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ser119Ala PPE35_p.Ser119Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1585 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1518 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ser12* PPE35_p.Ser12* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ser159Pro PPE35_p.Ser159Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ser206Asn PPE35_p.Ser206Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1519 1830 False False Inf 0.716637886286628 Inf 0 0 0.000836699794980095 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ser21fs PPE35_p.Ser21fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ser239fs PPE35_p.Ser239fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1570 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1504 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ser239Pro PPE35_p.Ser239Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ser249Leu PPE35_p.Ser249Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ser348Arg PPE35_p.Ser348Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1496 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1432 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ser416Arg PPE35_p.Ser416Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ser450Arg PPE35_p.Ser450Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 148.439276452294 1 1273 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 164.847877704944 1 927 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ser464Phe PPE35_p.Ser464Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1573 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1507 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ser471Ala PPE35_p.Ser471Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 20 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ser47Leu PPE35_p.Ser47Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ser536Leu PPE35_p.Ser536Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ser536Pro PPE35_p.Ser536Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ser616Arg PPE35_p.Ser616Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1661 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1593 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Ser616Ile PPE35_p.Ser616Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1586 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1519 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ser616Thr PPE35_p.Ser616Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Ser621Gly PPE35_p.Ser621Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 7 4409 16815 0 0 0.000836320411980403 0.999583878254666 0.99914281931165 0.999832681632407 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1480 1830 False False 0 0 2.64713852578052 0 0 0.000836320411980403 0.999583878254666 0.99914281931165 0.999832681632407 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 7 3786 16039 0 0 0.000973872929872615 0.999563754206656 0.999101374817905 0.99982458915172 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1415 1762 False False 0 0 0 0 0 0 0 0 0 2.94057641353956 0 0 0.000973872929872615 0.999563754206656 0.999101374817905 0.99982458915172 1 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Ser626Arg PPE35_p.Ser626Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Ser636Ala PPE35_p.Ser636Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1587 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1520 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ser645Ile PPE35_p.Ser645Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1673 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1605 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 3 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Ser730fs PPE35_p.Ser730fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1617 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1548 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ser740Asn PPE35_p.Ser740Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1650 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1582 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Ser868Arg PPE35_p.Ser868Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 163 2 4246 16820 0.0369698344295758 0.0315955022033961 0.0429681086332695 0.999881108072762 0.999570588169705 0.999985601311719 0.987878787878788 0.956901799424608 0.998528679274499 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1490 1830 False False 322.852096090438 87.9661986093094 2755.75536343694 0 0 0.000868412032155956 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 161 2 3625 16044 0.0425250924458531 0.0363210088677435 0.0494472014044384 0.999875358344758 0.999549824781286 0.999984904960856 0.987730061349693 0.956381461656562 0.998510584019953 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1425 1762 False False 0 0 0 0 0 0 0 356.287448275862 96.8825086100132 3083.50247184163 0 0 0.001017104316781 0.999875358344758 0.999549824781286 0.999984904960856 66 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Ser914Leu PPE35_p.Ser914Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 2 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Ser941Ala PPE35_p.Ser941Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 4409 16816 0 0 0.000836320411980403 0.999643324218285 0.999223829869625 0.999869095386533 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.24030155506377 0.355876504746108 489.5 1830 False False 0 0 3.24030155506377 0 0 0.000836320411980403 0.999643324218285 0.999223829869625 0.999869095386533 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 3786 16040 0 0 0.000973872929872615 0.999626075034276 0.999186301793093 0.999862764161372 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.59982301180526 0.602786000899522 522.5 1762 False False 0 0 0 0 0 0 0 0 0 3.59982301180526 0 0 0.000973872929872615 0.999626075034276 0.999186301793093 0.999862764161372 8 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Ser948Ile PPE35_p.Ser948Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 38 4409 16784 0 0 0.000836320411980403 0.997741053382475 0.996900724391019 0.998400954232259 0 0 0.0925127614158782 NA NA NA 0 0 0.0925127614158782 NA NA NA NA 1464 1830 False True 0 0 0.388274640689934 0 0 0.000836320411980403 0.997741053382475 0.996900724391019 0.998400954232259 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 38 3786 16008 0 0 0.000973872929872615 0.997631808550417 0.996750906627198 0.99832359844901 0 0 0.0925127614158782 NA NA NA 0 0 0.0925127614158782 NA NA NA NA 1399 1762 False True 1 1 1 0 0 0 0 0 0 0.431333375741561 0 0 0.000973872929872615 0.997631808550417 0.996750906627198 0.99832359844901 148 5) Not assoc w R UP from Uncertain to NotAwR yes 4 +Pyrazinamide PPE35 p.Thr277Lys PPE35_p.Thr277Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.23555131695149 1 1273 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 10.2590571436125 1 554.5 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 7 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Thr302Ile PPE35_p.Thr302Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Thr349Pro PPE35_p.Thr349Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Thr349Ser PPE35_p.Thr349Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1548 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1483 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Thr369Ile PPE35_p.Thr369Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Thr36Ala PPE35_p.Thr36Ala 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1509 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1445 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Thr399Ala PPE35_p.Thr399Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Thr401Asn PPE35_p.Thr401Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Thr404Met PPE35_p.Thr404Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 7 4409 16815 0 0 0.000836320411980403 0.999583878254666 0.99914281931165 0.999832681632407 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 2.64713852578052 0.357432235618625 497.5 1830 False False 0 0 2.64713852578052 0 0 0.000836320411980403 0.999583878254666 0.99914281931165 0.999832681632407 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 3786 16040 0 0 0.000973872929872615 0.999626075034276 0.999186301793093 0.999862764161372 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.59982301180526 0.602786000899522 522.5 1762 False False 0 0 0 0 0 0 0 0 0 3.59982301180526 0 0 0.000973872929872615 0.999626075034276 0.999186301793093 0.999862764161372 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Thr414Ala PPE35_p.Thr414Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 4408 16821 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1529 1830 False False 3.81601633393829 0.0486026416232846 298.829108180248 0 0 0.000836510060464794 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 3785 16045 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1464 1762 False False 0 0 0 0 0 0 0 4.23910171730515 0.0539892730999128 331.863925136224 0 0 0.000974130102511011 0.999937679172379 0.999652820032955 0.999998422174497 7 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Thr419fs PPE35_p.Thr419fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Thr434Ala PPE35_p.Thr434Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1549 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1484 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Thr491Met PPE35_p.Thr491Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 6 4409 16816 0 0 0.000836320411980403 0.999643324218285 0.999223829869625 0.999869095386533 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1579 1830 False False 0 0 3.24030155506377 0 0 0.000836320411980403 0.999643324218285 0.999223829869625 0.999869095386533 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 3786 16040 0 0 0.000973872929872615 0.999626075034276 0.999186301793093 0.999862764161372 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1512 1762 False False 0 0 0 0 0 0 0 0 0 3.59982301180526 0 0 0.000973872929872615 0.999626075034276 0.999186301793093 0.999862764161372 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Thr497Ala PPE35_p.Thr497Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 4408 16821 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 148.49048666616 1 897.5 1830 False False 3.81601633393829 0.0486026416232846 298.829108180248 0 0 0.000836510060464794 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 3785 16045 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 164.911820358037 1 927 1762 False False 0 0 0 0 0 0 0 4.23910171730515 0.0539892730999128 331.863925136224 0 0 0.000974130102511011 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Thr497Pro PPE35_p.Thr497Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Thr49Ala PPE35_p.Thr49Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Thr518Ala PPE35_p.Thr518Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1510 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1446 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Thr523Ala PPE35_p.Thr523Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1662 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1594 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Thr523Met PPE35_p.Thr523Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 4408 16821 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 148.49048666616 1 897.5 1830 False False 3.81601633393829 0.0486026416232846 298.829108180248 0 0 0.000836510060464794 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 3785 16045 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 164.911820358037 1 927 1762 False False 0 0 0 0 0 0 0 4.23910171730515 0.0539892730999128 331.863925136224 0 0 0.000974130102511011 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Thr533Ala PPE35_p.Thr533Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 21 7 4388 16815 0.00476298480381038 0.00295070754491831 0.00727156014129481 0.999583878254666 0.99914281931165 0.999832681632407 0.75 0.551284548471391 0.893092008170773 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1530 1830 False False 11.4961257976299 4.70326778268646 32.0094106454979 0 0 0.000840321174838721 0.999583878254666 0.99914281931165 0.999832681632407 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 21 7 3765 16039 0.00554675118858954 0.00343670743226419 0.00846636420321878 0.999563754206656 0.999101374817905 0.99982458915172 0.75 0.551284548471391 0.893092008170773 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1465 1762 False False 0 0 0 0 0 0 0 12.7800796812749 5.22793055166288 35.570079229985 0 0 0.00097930222980584 0.999563754206656 0.999101374817905 0.99982458915172 38 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Thr533Lys PPE35_p.Thr533Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1626 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1557 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Thr542Ala PPE35_p.Thr542Ala 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 8 4408 16814 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999524432291047 0.999063158238902 0.999794661972981 0.111111111111111 0.00280913674659921 0.482496514917337 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1602 1830 False False 0.476803539019963 0.0107465349444348 3.55811644738743 0 0 0.000836510060464794 0.999524432291047 0.999063158238902 0.999794661972981 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 7 3785 16039 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999563754206656 0.999101374817905 0.99982458915172 0.125 0.0031597235312519 0.526509670875206 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1535 1762 False False 0 0 0 0 0 0 0 0.605359501792791 0.0134317907447528 4.71432113745169 0 0 0.000974130102511011 0.999563754206656 0.999101374817905 0.99982458915172 4 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Thr542Lys PPE35_p.Thr542Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Thr543Met PPE35_p.Thr543Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 10 4408 16812 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999405540363809 0.998907040193061 0.999714897863756 0.0909090909090909 0.00229897221381426 0.412779916988382 0 0 0.841886116991581 0 0 0.30849710781876 0 0 20.3176414447203 1 1273 1830 False False 0.381397459165154 0.00878994715518856 2.68235121662762 0 0 0.000836510060464794 0.999405540363809 0.998907040193061 0.999714897863756 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 9 3785 16037 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999439112551414 0.998935529133907 0.999743495490327 0.1 0.00252857854446178 0.445016117028195 0 0 0.841886116991581 0 0 0.336267116879942 0 0 22.5669901639275 1 927 1762 False False 0 0 0 0 0 0 0 0.470776456773814 0.0107413348195793 3.39934587117999 0 0 0.000974130102511011 0.999439112551414 0.998935529133907 0.999743495490327 4 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Thr549Ala PPE35_p.Thr549Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1607 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1539 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Thr549Pro PPE35_p.Thr549Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1588 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1521 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Thr564Arg PPE35_p.Thr564Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1512 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1448 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Thr574Arg PPE35_p.Thr574Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1513 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1449 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Thr574fs PPE35_p.Thr574fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1589 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1522 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Thr574Lys PPE35_p.Thr574Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 4409 16817 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.16390782018879 0.590722354627394 560.5 1830 False False 0 0 4.16390782018879 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 3786 16041 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.62556638995023 0.590888399193514 509 1762 False False 0 0 0 0 0 0 0 0 0 4.62556638995023 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Thr590Ala PPE35_p.Thr590Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1556 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1491 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Thr590Met PPE35_p.Thr590Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1465 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1400 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Thr590Ser PPE35_p.Thr590Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1514 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1450 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Thr600fs PPE35_p.Thr600fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 162 2 4247 16820 0.0367430256293944 0.0313853030447731 0.0427250432800341 0.999881108072762 0.999570588169705 0.999985601311719 0.98780487804878 0.95664319146076 0.998519686944246 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1674 1830 False False 320.795855898281 87.337088571361 2736.25833371511 0 0 0.000868207644366455 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 160 2 3626 16044 0.0422609614368726 0.0360761919865892 0.049164226260205 0.999875358344758 0.999549824781286 0.999984904960856 0.987654320987654 0.956116553147646 0.99850136844874 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1606 1762 False False 0 0 0 0 0 0 0 353.976833976834 96.2665561243177 3060.59249656525 0 0 0.00101682395631951 0.999875358344758 0.999549824781286 0.999984904960856 64 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Thr601Ala PPE35_p.Thr601Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 1 6 4408 16816 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999643324218285 0.999223829869625 0.999869095386533 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.521823750104981 0 0 0.4592581264399 0 0 4.16460506207058 0.590719723256246 554.5 1830 False False 0.635813672111312 0.0138232628839914 5.24325822004213 0 0 0.000836510060464794 0.999643324218285 0.999223829869625 0.999869095386533 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 1 6 3785 16040 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999626075034276 0.999186301793093 0.999862764161372 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.521823750104981 0 0 0.4592581264399 0 0 4.62650046025696 0.590892150081256 515.5 1762 False False 0 0 0 0 0 0 0 0.706296785557023 0.0153546142757778 5.82369259713769 0 0 0.000974130102511011 0.999626075034276 0.999186301793093 0.999862764161372 3 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Thr609Met PPE35_p.Thr609Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 4409 16817 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 5.77993884793644 0.58676144625344 535 1830 False False 0 0 4.16390782018879 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 5 3786 16041 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 6.42069813886719 1 927 1762 False False 0 0 0 0 0 0 0 0 0 4.62556638995023 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Thr612Ala PPE35_p.Thr612Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1557 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1492 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 4 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Thr612Ser PPE35_p.Thr612Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Thr632Ala PPE35_p.Thr632Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1608 1830 False False Inf 0.716637886286628 Inf 0 0 0.000836699794980095 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1540 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0 0 0.000974387411009493 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Thr632Met PPE35_p.Thr632Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 3 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Thr632Pro PPE35_p.Thr632Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 1 3 2 3 4407 16819 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.999821662109142 0.999478910338162 0.999963220929399 0.4 0.0527449505263169 0.853367200365326 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 1.27214280311625 0.0242270206955864 15.8461157246728 1 1273 1830 False False 2.5442856062325 0.212429984141661 22.2163543346012 0.000226860254083484 5.74358785768897e-06 0.0012633291757201 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 1 3 2 3 3784 16043 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999813037517138 0.999453714469566 0.999961442181588 0.4 0.0527449505263169 0.853367200365326 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 1.41323114869626 0.0269129621989977 17.6044655311112 0.571394544786358 500 1762 False False 0 0 0 0 0 0 0 2.82646229739253 0.235979261609975 24.6811314932427 0.000264200792602377 6.68896256519433e-06 0.00147114392376758 0.999813037517138 0.999453714469566 0.999961442181588 3 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Thr643Ala PPE35_p.Thr643Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 3 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Thr650Ala PPE35_p.Thr650Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1543 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1478 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Thr689Ala PPE35_p.Thr689Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1590 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1523 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 5 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Thr712fs PPE35_p.Thr712fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Thr712Pro PPE35_p.Thr712Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 39 76 4370 16746 0.00884554320707643 0.00629739229832351 0.0120724992806418 0.99548210676495 0.994348399757231 0.996438811855549 0.339130434782608 0.253470668100091 0.433301439871409 NA NA NA 0 0 0.0473787538669306 NA NA NA NA NA NA False True 1.96643984102131 1.29909008015044 2.93449363314723 0 0 0.000843780991299104 0.99548210676495 0.994348399757231 0.996438811855549 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 37 55 3749 15991 0.00977284733227681 0.00689005810881129 0.0134456499584618 0.996572354480867 0.995540755730349 0.997416816028336 0.402173913043478 0.301230624252987 0.509596042253925 NA NA NA 0 0 0.0648707608254246 NA NA NA NA NA NA False True 0 1 1 0 0 1 0 2.86945367249448 1.83566136171983 4.43945626603699 0 0 0.000983479644627032 0.996572354480867 0.995540755730349 0.997416816028336 171 Not assoc w R 5) Not assoc w R No change yes 1 +Pyrazinamide PPE35 p.Thr735fs PPE35_p.Thr735fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1574 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1508 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Thr741Asn PPE35_p.Thr741Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Thr750Met PPE35_p.Thr750Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 4409 16818 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1618 1830 False False 0 0 5.78028251232769 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 3786 16042 0 0 0.000973872929872615 0.999750716689517 0.999361859844744 0.999932074644789 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1549 1762 False False 0 0 0 0 0 0 0 0 0 6.42109836734015 0 0 0.000973872929872615 0.999750716689517 0.999361859844744 0.999932074644789 4 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Thr765Ile PPE35_p.Thr765Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 82 2 4327 16820 0.0185983216148786 0.0148184321699997 0.0230334708786714 0.999881108072762 0.999570588169705 0.999985601311719 0.976190476190476 0.916625533433094 0.997103437029467 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1640 1830 False False 159.376011093136 42.7034707023081 1351.31979400824 0 0 0.000852162576444649 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 80 2 3706 16044 0.0211304807184363 0.0167898360137847 0.0262305210634137 0.999875358344758 0.999549824781286 0.999984904960856 0.975609756097561 0.914656775044917 0.997032458448577 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1571 1762 False False 0 0 0 0 0 0 0 173.167835941716 46.3298198046936 1345.61025792727 0 0 0.000994885090153371 0.999875358344758 0.999549824781286 0.999984904960856 35 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Thr765Pro PPE35_p.Thr765Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Thr770Arg PPE35_p.Thr770Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 9 0 9 0 9 4409 16813 0 0 0.000836320411980403 0.999464986327428 0.998984621445092 0.999755329427402 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.336267116879942 0 0 1.9328143827158 0.219086249473785 468 1830 False False 0 0 1.9328143827158 0 0 0.000836320411980403 0.999464986327428 0.998984621445092 0.999755329427402 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 0 9 3786 16037 0 0 0.000973872929872615 0.999439112551414 0.998935529133907 0.999743495490327 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.336267116879942 0 0 2.14715011586227 0.222588131410409 446.5 1762 False False 0 0 0 0 0 0 0 0 0 2.14715011586227 0 0 0.000973872929872615 0.999439112551414 0.998935529133907 0.999743495490327 3 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Thr780fs PPE35_p.Thr780fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1520 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1455 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Thr820Ala PPE35_p.Thr820Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1609 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1541 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Thr835Pro PPE35_p.Thr835Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1472 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1407 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Thr845Ala PPE35_p.Thr845Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 32 4409 16790 0 0 0.000836320411980403 0.998097729164189 0.997315612940588 0.99869849551898 0 0 0.108881160679352 NA NA NA 0 0 0.108881160679352 NA NA NA NA 1521 1830 False False 0 0 0.465549904466373 0 0 0.000836320411980403 0.998097729164189 0.997315612940588 0.99869849551898 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 32 3786 16014 0 0 0.000973872929872615 0.998005733516141 0.997185846734806 0.998635535618626 0 0 0.108881160679352 NA NA NA 0 0 0.108881160679352 NA NA NA NA 1456 1762 False False 0 0 0 0 0 0 0 0 0 0.517131841158514 0 0 0.000973872929872615 0.998005733516141 0.997185846734806 0.998635535618626 9 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Thr845Ile PPE35_p.Thr845Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Thr846Ala PPE35_p.Thr846Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 3 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Thr846fs PPE35_p.Thr846fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Thr846Met PPE35_p.Thr846Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 44 5 39 6 43 4403 16779 0.00136085280108868 0.000499567554195151 0.00295963286153356 0.99744382356438 0.996558374595514 0.998149483637672 0.122448979591836 0.0462890310818957 0.247692968359682 0.113636363636363 0.0379437129392748 0.245576776315531 0.104166666666666 0.034698122121196 0.226577661283763 0.488565488565488 0.150207102689625 1.24154037780083 0.139077175186014 319 1830 False False 0.53174104336895 0.184845113871835 1.25581862655428 0.00113430127041742 0.000368403864880028 0.00264507905390205 0.99744382356438 0.996558374595514 0.998149483637672 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 44 5 39 6 43 3780 16003 0.00158478605388272 0.000581803608073282 0.0034461969631646 0.997320204412314 0.996392011747749 0.998059960498693 0.122448979591836 0.0462890310818957 0.247692968359682 0.113636363636363 0.0379437129392748 0.245576776315531 0.104166666666666 0.034698122121196 0.226577661283763 0.542768959435626 0.166843663281088 1.3794548107509 0.249006330909079 456 1762 False False 0 0 0 0 0 0 0 0.590734588409007 0.205309340433543 1.39535747875142 0.00132100396301188 0.000429061121297529 0.00308006778073064 0.997320204412314 0.996392011747749 0.998059960498693 24 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Thr860Ile PPE35_p.Thr860Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 6 4409 16816 0 0 0.000836320411980403 0.999643324218285 0.999223829869625 0.999869095386533 0 0 0.4592581264399 0 0 0.707598226178713 0 0 0.4592581264399 0 0 9.23390453630985 1 1273 1830 False False 0 0 3.24030155506377 0 0 0.000836320411980403 0.999643324218285 0.999223829869625 0.999869095386533 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 6 3786 16040 0 0 0.000973872929872615 0.999626075034276 0.999186301793093 0.999862764161372 0 0 0.4592581264399 0 0 0.707598226178713 0 0 0.4592581264399 0 0 10.2571396130567 1 927 1762 False False 0 0 0 0 0 0 0 0 0 3.59982301180526 0 0 0.000973872929872615 0.999626075034276 0.999186301793093 0.999862764161372 6 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Thr861Ala PPE35_p.Thr861Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Thr865Ile PPE35_p.Thr865Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 2 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Thr922Ala PPE35_p.Thr922Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 1 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Thr956Ile PPE35_p.Thr956Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 2 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Thr986Ala PPE35_p.Thr986Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 1 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Trp144* PPE35_p.Trp144* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Trp31* PPE35_p.Trp31* 2 stop_gained (see "Genomic_coordinates" sheet) 1 3 0 3 0 11 4409 16811 0 0 0.000836320411980403 0.99934609440019 0.998830284178405 0.999673528922672 0 0 0.284914152918154 0 0 0.707598226178713 0 0 0.284914152918154 0 0 9.23115990082594 1 897.5 1830 False False 0 0 1.51991683293768 0 0 0.000836320411980403 0.99934609440019 0.998830284178405 0.999673528922672 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 11 3786 16035 0 0 0.000973872929872615 0.999314470896173 0.998773730902855 0.999657738248111 0 0 0.284914152918154 0 0 0.707598226178713 0 0 0.284914152918154 0 0 10.2539437279062 1 927 1762 False False 0 0 0 0 0 0 0 0 0 1.68837982812114 0 0 0.000973872929872615 0.999314470896173 0.998773730902855 0.999657738248111 13 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Trp411* PPE35_p.Trp411* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 6 4409 16816 0 0 0.000836320411980403 0.999643324218285 0.999223829869625 0.999869095386533 0 0 0.4592581264399 0 0 0.975 0 0 0.4592581264399 0 0 148.412862352464 1 897.5 1830 False False 0 0 3.24030155506377 0 0 0.000836320411980403 0.999643324218285 0.999223829869625 0.999869095386533 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 6 3786 16040 0 0 0.000973872929872615 0.999626075034276 0.999186301793093 0.999862764161372 0 0 0.4592581264399 0 0 0.975 0 0 0.4592581264399 0 0 164.817132875047 1 927 1762 False False 0 0 0 0 0 0 0 0 0 3.59982301180526 0 0 0.000973872929872615 0.999626075034276 0.999186301793093 0.999862764161372 9 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Trp919fs PPE35_p.Trp919fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Tyr154fs PPE35_p.Tyr154fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Tyr443His PPE35_p.Tyr443His 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Tyr887Ser PPE35_p.Tyr887Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Tyr887* PPE35_p.Tyr887* 2 stop_gained (see "Genomic_coordinates" sheet) 0 0 0 0 2 2 4407 16820 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.999881108072762 0.999570588169705 0.999985601311719 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1619 1830 False False 3.8166553210801 0.276553001924986 52.6392074577436 0 0 0.000836699794980095 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 2 3784 16044 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999875358344758 0.999549824781286 0.999984904960856 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1550 1762 False False 0 0 0 0 0 0 0 4.2399577167019 0.307210542317908 58.5302826936734 0 0 0.000974387411009493 0.999875358344758 0.999549824781286 0.999984904960856 2 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Val110Leu PPE35_p.Val110Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 4409 16818 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1544 1830 False False 0 0 5.78028251232769 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 3786 16042 0 0 0.000973872929872615 0.999750716689517 0.999361859844744 0.999932074644789 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1479 1762 False False 0 0 0 0 0 0 0 0 0 6.42109836734015 0 0 0.000973872929872615 0.999750716689517 0.999361859844744 0.999932074644789 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Val121Ala PPE35_p.Val121Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Val161_Ala183del PPE35_p.Val161_Ala183del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1663 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1595 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Val163Leu PPE35_p.Val163Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1522 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1457 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Val193Ala PPE35_p.Val193Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 6 4408 16816 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999643324218285 0.999223829869625 0.999869095386533 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.707598226178713 0 0 0.4592581264399 0 0 9.23599917582101 1 1273 1830 False False 0.635813672111312 0.0138232628839914 5.24325822004213 0 0 0.000836510060464794 0.999643324218285 0.999223829869625 0.999869095386533 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 5 3786 16041 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 10.2577787899531 1 927 1762 False False 0 0 0 0 0 0 0 0 0 4.62556638995023 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 6 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Val193Met PPE35_p.Val193Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.716800488047171 Inf 0.0431027624717359 243 1830 False False Inf 1.57702975056642 Inf 0.000453720508166969 5.49523823434802e-05 0.00163802343880428 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.796287283318118 Inf 0.0364208169216465 224.5 1762 False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf 0.000528401585204755 6.39982904626514e-05 0.00190745126237675 1 0.999770132403032 1 4 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Val212Phe PPE35_p.Val212Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1634 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1565 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Val374fs PPE35_p.Val374fs 2 frameshift (see "Genomic_coordinates" sheet) 1 4 0 4 1 5 4408 16817 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999702770181904 0.999306502227134 0.999903483469113 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.602364635616474 0 0 0.521823750104981 0 0 5.78125038223797 0.586777316023966 549 1830 False False 0.763021778584392 0.0161324685427033 6.82117624035202 0 0 0.000836510060464794 0.999702770181904 0.999306502227134 0.999903483469113 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 1 5 3785 16041 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999688395861897 0.99927297097682 0.999898815491092 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.602364635616474 0 0 0.521823750104981 0 0 6.42239493144746 1 927 1762 False False 0 0 0 0 0 0 0 0.847608982826948 0.0179160496983802 7.57805461545705 0 0 0.000974130102511011 0.999688395861897 0.99927297097682 0.999898815491092 7 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Val43Ala PPE35_p.Val43Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1466 1830 False False Inf 1.57702975056642 Inf 0 0 0.000836889615584862 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1401 1762 False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf 0 0 0.000974644855475749 1 0.999770132403032 1 5 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Val446Leu PPE35_p.Val446Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Val48Met PPE35_p.Val48Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1558 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1493 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Val490Ala PPE35_p.Val490Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 8 4409 16814 0 0 0.000836320411980403 0.999524432291047 0.999063158238902 0.999794661972981 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1497 1830 False False 0 0 2.2350715489366 0 0 0.000836320411980403 0.999524432291047 0.999063158238902 0.999794661972981 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 8 3786 16038 0 0 0.000973872929872615 0.999501433379035 0.999017862631239 0.999784730530787 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1433 1762 False False 0 0 0 0 0 0 0 0 0 2.48286669292342 0 0 0.000973872929872615 0.999501433379035 0.999017862631239 0.999784730530787 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Val496Ile PPE35_p.Val496Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 4 4408 16818 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999762216145523 0.999391291831884 0.999935208223951 0.2 0.00505076337946806 0.716417936118089 0 0 0.975 0 0 0.602364635616474 0 0 148.464066616397 1 897.5 1830 False False 0.95383393829401 0.0193637820130019 9.63941079069668 0 0 0.000836510060464794 0.999762216145523 0.999391291831884 0.999935208223951 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 4 3785 16042 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999750716689517 0.999361859844744 0.999932074644789 0.2 0.00505076337946806 0.716417936118089 0 0 0.975 0 0 0.602364635616474 0 0 164.881067466937 1 927 1762 False False 0 0 0 0 0 0 0 1.05957727873183 0.0215096981131212 10.714411563858 0 0 0.000974130102511011 0.999750716689517 0.999361859844744 0.999932074644789 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Val498Gly PPE35_p.Val498Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1651 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1583 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Val508fs PPE35_p.Val508fs 2 frameshift (see "Genomic_coordinates" sheet) 1 9 0 9 0 9 4409 16813 0 0 0.000836320411980403 0.999464986327428 0.998984621445092 0.999755329427402 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.336267116879942 0 0 1.9328143827158 0.219086249473785 468 1830 False False 0 0 1.9328143827158 0 0 0.000836320411980403 0.999464986327428 0.998984621445092 0.999755329427402 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 0 9 3786 16037 0 0 0.000973872929872615 0.999439112551414 0.998935529133907 0.999743495490327 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.336267116879942 0 0 2.14715011586227 0.222588131410409 446.5 1762 False False 0 0 0 0 0 0 0 0 0 2.14715011586227 0 0 0.000973872929872615 0.999439112551414 0.998935529133907 0.999743495490327 3 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Val565Phe PPE35_p.Val565Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 62 0 4347 16822 0.0140621456112497 0.0107979064702827 0.0179912242208669 1 0.999780735048249 1 1 0.942237365570709 1 NA NA NA NA NA NA NA NA NA NA 1635 1830 False False Inf 63.0491990902278 Inf 0 0 0.000848243546984005 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 62 0 3724 16046 0.0163761225567881 0.0125779279974125 0.0209448658834386 1 0.999770132403032 1 1 0.942237365570709 1 NA NA NA NA NA NA NA NA NA NA 1566 1762 False False 0 0 0 0 0 0 0 Inf 70.230204901348 Inf 0 0 0.000990078682108847 1 0.999770132403032 1 23 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Val5Ala PPE35_p.Val5Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 13 4407 16809 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.999227202472952 0.998678855253688 0.999588455738321 0.133333333333333 0.0165759134400836 0.404602696603372 0 0 0.975 0 0 0.24705263800047 0 0 148.418398506655 1 897.5 1830 False False 0.586793737236215 0.0642661236491552 2.5935672627138 0 0 0.000836699794980095 0.999227202472952 0.998678855253688 0.999588455738321 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 13 3784 16033 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999189829240932 0.998614981804171 0.999568549911067 0.133333333333333 0.0165759134400836 0.404602696603372 0 0 0.975 0 0 0.24705263800047 0 0 164.832245295135 1 927 1762 False False 0 0 0 0 0 0 0 0.651853959993494 0.0713878431275329 2.88127358036689 0 0 0.000974387411009493 0.999189829240932 0.998614981804171 0.999568549911067 8 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Val63Gly PPE35_p.Val63Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Val63Leu PPE35_p.Val63Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Val656Gly PPE35_p.Val656Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Val672Ala PPE35_p.Val672Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1502 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1438 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Val672Leu PPE35_p.Val672Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Val694Ala PPE35_p.Val694Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1620 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1551 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Val694Gly PPE35_p.Val694Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1603 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Val694Leu PPE35_p.Val694Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 20 1 19 1 19 4408 16803 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.998870526691237 0.998236746975561 0.999319850622688 0.05 0.0012650894979498 0.248732762772027 0.05 0.0012650894979498 0.248732762772027 0.05 0.0012650894979498 0.248732762772027 0.20062804470341 0.00483110155934281 1.26281885604434 0.0986735642159162 302 1830 False False 0.20062804470341 0.00483110155934281 1.26281885604434 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.998870526691237 0.998236746975561 0.999319850622688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 19 1 18 1 18 3785 16028 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.998878225102829 0.998227689237744 0.999335033867569 0.0526315789473684 0.00133162880417942 0.260280654195214 0.0526315789473684 0.00133162880417942 0.260280654195214 0.0526315789473684 0.00133162880417942 0.260280654195214 0.235256127990606 0.00564851425373584 1.49102455534335 0.152197410534698 302 1762 False False 0 0 0 0 0 0 0 0.235256127990606 0.00564851425373584 1.49102455534335 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.998878225102829 0.998227689237744 0.999335033867569 5 3) Uncertain significance No change no 1 +Pyrazinamide PPE35 p.Val702Ala PPE35_p.Val702Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1664 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1596 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Val719Ile PPE35_p.Val719Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 4 3) Uncertain significance New Uncertain no 0 +Pyrazinamide PPE35 p.Val967Ala PPE35_p.Val967Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide rpsA c.1020C>T rpsA_c.1020C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.1023C>T rpsA_c.1023C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.1029C>T rpsA_c.1029C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0978301145652783 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.105T>C rpsA_c.105T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 29 4409 16793 0 0 0.000836320411980403 0.998276067055047 0.997525075697192 0.998845160492959 0 0 0.119444869069502 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.516929749574874 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 28 3786 16018 0 0 0.000973872929872615 0.998255016826623 0.997478993411849 0.998840167868832 0 0 0.123436118500263 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.596141506464563 NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.1071G>A rpsA_c.1071G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.-10A>G rpsA_c.-10A>G 2 upstream_gene_variant 1833532 1 0 0 0 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1406 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1347 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA c.1110C>T rpsA_c.1110C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.1116G>A rpsA_c.1116G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.1119C>T rpsA_c.1119C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.1125G>T rpsA_c.1125G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.1155C>T rpsA_c.1155C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.117C>G rpsA_c.117C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 3 4408 16819 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999821662109142 0.999478910338162 0.999963220929399 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.2718542044767 0.0242215257537785 15.8425197757275 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 3 3785 16043 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999813037517138 0.999453714469566 0.999961442181588 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.41285777190664 0.0269058536042688 17.5998124179982 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.1203C>T rpsA_c.1203C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.1248T>A rpsA_c.1248T>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 4409 16818 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.78028251232769 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 3786 16042 0 0 0.000973872929872615 0.999750716689517 0.999361859844744 0.999932074644789 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.42109836734015 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.1254C>T rpsA_c.1254C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.716637886286628 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.1257C>T rpsA_c.1257C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0978301145652783 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.1272G>A rpsA_c.1272G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.1305C>T rpsA_c.1305C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.1317G>A rpsA_c.1317G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.1332C>T rpsA_c.1332C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.1335G>C rpsA_c.1335G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 3 4408 16819 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999821662109142 0.999478910338162 0.999963220929399 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.2718542044767 0.0242215257537785 15.8425197757275 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 3 3785 16043 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999813037517138 0.999453714469566 0.999961442181588 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.41285777190664 0.0269058536042688 17.5998124179982 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.1344G>A rpsA_c.1344G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.1347G>T rpsA_c.1347G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.1353C>T rpsA_c.1353C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.1356T>C rpsA_c.1356T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 4409 16817 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.16390782018879 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 5 3786 16041 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.62556638995023 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.1371A>G rpsA_c.1371A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.1395C>T rpsA_c.1395C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 0 4405 16822 0.000907235200725788 0.000247244623732042 0.00232123869101376 1 0.999780735048249 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 2.51959224712996 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 4 0 3782 16046 0.00105652403592181 0.000287939890647285 0.00270289202199999 1 0.999770132403032 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 2.79918348098377 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.1416C>T rpsA_c.1416C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.142C>A rpsA_c.142C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.1431C>T rpsA_c.1431C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0978301145652783 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.-14A>T rpsA_c.-14A>T 2 upstream_gene_variant 1833528 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA c.15C>G rpsA_c.15C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.162C>T rpsA_c.162C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.186G>A rpsA_c.186G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 4409 16818 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.78028251232769 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 3786 16042 0 0 0.000973872929872615 0.999750716689517 0.999361859844744 0.999932074644789 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.42109836734015 NA NA NA NA NA NA 13 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.18C>A rpsA_c.18C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.204G>A rpsA_c.204G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.716637886286628 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.210C>T rpsA_c.210C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.219C>T rpsA_c.219C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.21C>T rpsA_c.21C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.-21T>C rpsA_c.-21T>C 2 upstream_gene_variant 1833521 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1392 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1335 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA c.222C>T rpsA_c.222C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.23555131695149 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.2590571436125 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.-25A>G rpsA_c.-25A>G 2 upstream_gene_variant 1833517 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA c.276C>T rpsA_c.276C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.716637886286628 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.27G>C rpsA_c.27G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.-2A>G rpsA_c.-2A>G 2 upstream_gene_variant 1833540 1 1 0 1 0 5 4409 16817 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 0 0 0.521823750104981 0 0 0.975 0 0 0.521823750104981 0 0 148.421667054835 1 1273 1830 False False 0 0 4.16390782018879 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 5 3786 16041 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 0 0 0.521823750104981 0 0 0.975 0 0 0.521823750104981 0 0 164.82738115497 1 927 1762 False False 0 0 0 0 0 0 0 0 0 4.62556638995023 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 14 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA c.-31delG rpsA_c.-31delG 2 upstream_gene_variant 1833510 1 2 0 2 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.3214799903419 1 1273 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA c.-32C>T rpsA_c.-32C>T 2 upstream_gene_variant 1833510 1 13 1 12 1 12 4408 16810 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999286648436571 0.998754250286254 0.999631348241016 0.0769230769230769 0.00194562849734675 0.360297435267877 0.0769230769230769 0.00194562849734675 0.360297435267877 0.0769230769230769 0.00194562849734675 0.360297435267877 0.317793405928614 0.00743600121915152 2.14903349744897 0.490196622083283 517 1830 False False 0.317793405928614 0.00743600121915152 2.14903349744897 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999286648436571 0.998754250286254 0.999631348241016 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 13 1 12 1 12 3785 16034 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999252150068553 0.998694021458847 0.999613517219799 0.0769230769230769 0.00194562849734675 0.360297435267877 0.0769230769230769 0.00194562849734675 0.360297435267877 0.0769230769230769 0.00194562849734675 0.360297435267877 0.35301629238221 0.00825940594276455 2.38755238851291 0.484105791663742 499 1762 False False 0 0 0 0 0 0 0 0.35301629238221 0.00825940594276455 2.38755238851291 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999252150068553 0.998694021458847 0.999613517219799 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA c.345C>T rpsA_c.345C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.23555131695149 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.2590571436125 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.357C>T rpsA_c.357C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.378C>T rpsA_c.378C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0978301145652783 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.393C>T rpsA_c.393C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.423C>T rpsA_c.423C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.-45_-44insA rpsA_c.-45_-44insA 2 upstream_gene_variant 1833497 1 7 0 7 0 7 4409 16815 0 0 0.000836320411980403 0.999583878254666 0.99914281931165 0.999832681632407 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 2.64713852578052 0.357432235618625 497.5 1830 False False 0 0 2.64713852578052 0 0 0.000836320411980403 0.999583878254666 0.99914281931165 0.999832681632407 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 7 3786 16039 0 0 0.000973872929872615 0.999563754206656 0.999101374817905 0.99982458915172 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 2.94057641353956 0.359641186358848 473.5 1762 False False 0 0 0 0 0 0 0 0 0 2.94057641353956 0 0 0.000973872929872615 0.999563754206656 0.999101374817905 0.99982458915172 4 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA c.454C>T rpsA_c.454C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.468C>A rpsA_c.468C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 25 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.-47A>G rpsA_c.-47A>G 2 upstream_gene_variant 1833495 1 3 0 3 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.23555131695149 1 1273 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA c.486G>A rpsA_c.486G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0978301145652783 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.-48T>C rpsA_c.-48T>C 2 upstream_gene_variant 1833494 1 0 0 0 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1384 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1328 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 3 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA c.-49G>T rpsA_c.-49G>T 2 upstream_gene_variant 1833493 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1424 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1364 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA c.-4C>T rpsA_c.-4C>T 2 upstream_gene_variant 1833538 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1450 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1386 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA c.-50G>A rpsA_c.-50G>A 2 upstream_gene_variant 1833492 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA c.-50G>T rpsA_c.-50G>T 2 upstream_gene_variant 1833492 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA c.-52C>T rpsA_c.-52C>T 2 upstream_gene_variant 1833490 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1425 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1366 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA c.546C>T rpsA_c.546C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.-54G>A rpsA_c.-54G>A 2 upstream_gene_variant 1833488 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA c.576G>A rpsA_c.576G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.-57C>G rpsA_c.-57C>G 2 upstream_gene_variant 1833485 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA c.603G>A rpsA_c.603G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.618G>A rpsA_c.618G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 88 4407 16734 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.994768755201522 0.99355887495168 0.995802337418543 0.0222222222222222 0.00270263585014775 0.0779776854776639 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.0862986570951172 0.010283572363637 0.32135093140985 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 2 88 3784 15958 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.994515767169388 0.993247574608533 0.99559923023461 0.0222222222222222 0.00270263585014775 0.0779776854776639 NA NA NA NA NA NA NA NA NA NA NA NA False True 1 1 1 0 0 0 0 0.0958461464539688 0.0114166167452252 0.356964673186644 NA NA NA NA NA NA 40 5) Not assoc w R Now listed Silent mutation no 0 +Pyrazinamide rpsA c.621A>G rpsA_c.621A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.627C>T rpsA_c.627C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.23555131695149 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.2590571436125 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.636A>C rpsA_c.636A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2086 3148 2323 13674 0.473123157178498 0.458294322711689 0.487987625720685 0.812864106527166 0.806886662902778 0.81873318124087 0.398547955674436 0.385248171139947 0.411960979663749 NA NA NA NA NA NA NA NA NA NA NA NA False True 3.90055086940659 3.63214369031142 4.18866291064442 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 1999 3008 1787 13038 0.527997886951928 0.511947582126953 0.54400493108113 0.812538950517262 0.806412656152225 0.818551736272724 0.399241062512482 0.385638032615317 0.412961679994138 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 0 1 0 0 0 1 4.84865614842419 4.49430211911475 5.23024623776626 NA NA NA NA NA NA 11584 Literature evidence (PMID 32143680) 4) Not assoc w R - Interim Now listed Silent mutation no Lit. (PMID 32143680) 0 +Pyrazinamide rpsA c.642T>C rpsA_c.642T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.651C>G rpsA_c.651C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.684C>T rpsA_c.684C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.-68C>T rpsA_c.-68C>T 2 upstream_gene_variant 1833474 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA c.693G>A rpsA_c.693G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 7 0 4402 16822 0.00158766160127012 0.000638553061192671 0.00326843667440656 1 0.999780735048249 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 5.50478416804174 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.693G>T rpsA_c.693G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.705G>A rpsA_c.705G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.720A>G rpsA_c.720A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 12 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.732C>T rpsA_c.732C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 4409 16816 0 0 0.000836320411980403 0.999643324218285 0.999223829869625 0.999869095386533 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.24030155506377 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 6 3786 16040 0 0 0.000973872929872615 0.999626075034276 0.999186301793093 0.999862764161372 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.59982301180526 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.738C>T rpsA_c.738C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.-73G>T rpsA_c.-73G>T 2 upstream_gene_variant 1833469 1 3 0 3 4 4 4405 16818 0.000907235200725788 0.000247244623732042 0.00232123869101376 0.999762216145523 0.999391291831884 0.999935208223951 0.5 0.157012770487058 0.842987229512941 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.24338764595809 1 897.5 1830 False False 3.81793416572077 0.710765129584011 20.502441796637 0 0 0.000837079522337697 0.999762216145523 0.999391291831884 0.999935208223951 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1343 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 24 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA c.744G>A rpsA_c.744G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0978301145652783 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.768C>T rpsA_c.768C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.774C>T rpsA_c.774C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 17 4408 16805 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.998989418618475 0.998382452772912 0.999411192380357 0.0555555555555555 0.00140555616736942 0.272943599673368 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.224258033521938 0.00536846248346029 1.43203726249083 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 17 3785 16029 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.99894054593045 0.998304251550396 0.999382711664247 0.0555555555555555 0.00140555616736942 0.272943599673368 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.249110264977853 0.00596269606976058 1.59084611373257 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.777C>G rpsA_c.777C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.807T>C rpsA_c.807T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 12 4409 16810 0 0 0.000836320411980403 0.999286648436571 0.998754250286254 0.999631348241016 0 0 0.264648469397051 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.37280707722974 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 11 3786 16035 0 0 0.000973872929872615 0.999314470896173 0.998773730902855 0.999657738248111 0 0 0.284914152918154 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.68837982812114 NA NA NA NA NA NA 12 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.813G>C rpsA_c.813G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.-81T>C rpsA_c.-81T>C 2 upstream_gene_variant 1833461 1 0 0 0 1 4 4408 16818 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999762216145523 0.999391291831884 0.999935208223951 0.2 0.00505076337946806 0.716417936118089 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1451 1830 False False 0.95383393829401 0.0193637820130019 9.63941079069668 0 0 0.000836510060464794 0.999762216145523 0.999391291831884 0.999935208223951 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 4 3785 16042 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999750716689517 0.999361859844744 0.999932074644789 0.2 0.00505076337946806 0.716417936118089 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1387 1762 False False 0 0 0 0 0 0 0 1.05957727873183 0.0215096981131212 10.714411563858 0 0 0.000974130102511011 0.999750716689517 0.999361859844744 0.999932074644789 6 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA c.822G>A rpsA_c.822G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 29 4408 16793 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.998276067055047 0.997525075697192 0.998845160492959 0.0333333333333333 0.000843570926630479 0.172169455633412 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.131367732649101 0.00321951935230726 0.792824589854799 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 29 3785 16017 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.998192695999002 0.997405433184333 0.998789296399478 0.0333333333333333 0.000843570926630479 0.172169455633412 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.14592083086594 0.00357555961337945 0.880733582721516 NA NA NA NA NA NA 32 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.825A>C rpsA_c.825A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.825A>G rpsA_c.825A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.23555131695149 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.2590571436125 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.-82G>A rpsA_c.-82G>A 2 upstream_gene_variant 1833460 1 1 0 1 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 148.448081147381 1 1273 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 164.858125974995 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA c.-82G>T rpsA_c.-82G>T 2 upstream_gene_variant 1833460 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 3 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA c.837T>C rpsA_c.837T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 9 8 4400 16814 0.00204127920163302 0.000933814369660709 0.00387143149170671 0.999524432291047 0.999063158238902 0.999794661972981 0.529411764705882 0.278118300331106 0.770167312734009 NA NA NA NA NA NA NA NA NA NA NA NA False False 4.29903409090909 1.4711550795387 12.8129202399637 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf NA NA NA NA NA NA 24 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.897C>T rpsA_c.897C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.903C>T rpsA_c.903C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 4408 16821 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.81601633393829 0.0486026416232846 298.829108180248 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 3785 16045 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.23910171730515 0.0539892730999128 331.863925136224 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.921C>T rpsA_c.921C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.936C>T rpsA_c.936C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.-95C>T rpsA_c.-95C>T 2 upstream_gene_variant 1833447 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1452 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1388 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA c.960G>A rpsA_c.960G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.969C>T rpsA_c.969C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA c.999G>T rpsA_c.999G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide rpsA LoF rpsA_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 1 0 1 4 2 4405 16820 0.000907235200725788 0.000247244623732042 0.00232123869101376 0.999881108072762 0.999570588169705 0.999985601311719 0.666666666666666 0.222778095503512 0.956728131707258 0 0 0.975 0 0 0.841886116991581 0 0 148.582567815888 1 1273 1830 False False 7.63677639046538 1.09391175338604 84.6254023086715 0 0 0.000837079522337697 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 4 2 3782 16044 0.00105652403592181 0.000287939890647285 0.00270289202199999 0.999875358344758 0.999549824781286 0.999984904960856 0.666666666666666 0.222778095503512 0.956728131707258 0 0 0.975 0 0 0.841886116991581 0 0 165.032037152779 1 927 1762 False False 0 0 0 0 0 0 0 8.4843997884717 1.21526196730161 93.8406264671703 0 0 0.000974902436017582 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Ala112Ser rpsA_p.Ala112Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1379 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1323 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Ala118Ser rpsA_p.Ala118Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Ala125Val rpsA_p.Ala125Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Ala150Ser rpsA_p.Ala150Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1436 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1375 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Ala171Thr rpsA_p.Ala171Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.3214799903419 1 1273 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 22.56946568665 1 927 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Ala189Pro rpsA_p.Ala189Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Ala189Ser rpsA_p.Ala189Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1398 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1339 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Ala189Thr rpsA_p.Ala189Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Ala224Gly rpsA_p.Ala224Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1407 1830 False False Inf 0.716637886286628 Inf 0 0 0.000836699794980095 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1348 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Ala24Gly rpsA_p.Ala24Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1448 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Ala25Thr rpsA_p.Ala25Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 4408 16821 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 148.49048666616 1 897.5 1830 False False 3.81601633393829 0.0486026416232846 298.829108180248 0 0 0.000836510060464794 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 3785 16045 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 164.911820358037 1 927 1762 False False 0 0 0 0 0 0 0 4.23910171730515 0.0539892730999128 331.863925136224 0 0 0.000974130102511011 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Ala278Glu rpsA_p.Ala278Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Ala339Thr rpsA_p.Ala339Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1422 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1362 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Ala365Val rpsA_p.Ala365Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Ala376Val rpsA_p.Ala376Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Ala381Val rpsA_p.Ala381Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 79 4 4330 16818 0.0179178952143343 0.014210774288574 0.0222816264131845 0.999762216145523 0.999391291831884 0.999935208223951 0.951807228915662 0.88118158277308 0.986714921921615 1 0.025 1 0.2 0.00505076337946806 0.716417936118089 Inf 0.0995683271361865 Inf 0.204785096222043 330 1830 False False 76.7102771362586 28.7730814651984 286.60984278124 0.000230893558069729 5.84570168183824e-06 0.00128577780422283 0.999762216145523 0.999391291831884 0.999935208223951 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 8 0 3778 16046 0.00211304807184363 0.00091269178353604 0.00415927925423806 1 0.999770132403032 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 1365 1762 False False 0 0 0 0 0 0 0 Inf 7.24385478693174 Inf 0 0 0.000975934121100684 1 0.999770132403032 1 96 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Ala412Val rpsA_p.Ala412Val 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 30 10 4379 16812 0.00680426400544341 0.00459537963726389 0.00969937133234855 0.999405540363809 0.998907040193061 0.999714897863756 0.75 0.58803801984857 0.873085201067155 NA NA NA 0 0 0.30849710781876 NA NA NA NA 1428 1830 False False 11.51769810459 5.47461883660347 26.4271115352726 0 0 0.000842047529148766 0.999405540363809 0.998907040193061 0.999714897863756 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 30 9 3756 16037 0.00792393026941363 0.00535244448152805 0.0112927265285391 0.999439112551414 0.998935529133907 0.999743495490327 0.769230769230769 0.606738459321532 0.888663058895853 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1368 1762 False False 0 0 0 0 0 0 0 14.2323393681221 6.57951002227642 34.1066597161181 0 0 0.000981647648514555 0.999439112551414 0.998935529133907 0.999743495490327 37 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Ala436Gly rpsA_p.Ala436Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1399 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1340 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Ala437Thr rpsA_p.Ala437Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1412 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1353 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Ala438del rpsA_p.Ala438del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 0 0 0 2 17 4407 16805 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.998989418618475 0.998382452772912 0.999411192380357 0.105263157894736 0.0130121643717774 0.331376664456765 NA NA NA 0 0 0.195064322969093 NA NA NA NA 1413 1830 False False 0.448617840601182 0.0502588745250511 1.89107052444533 0 0 0.000836699794980095 0.998989418618475 0.998382452772912 0.999411192380357 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 16 3784 16030 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.99900286675807 0.998381221815451 0.999429948179957 0.111111111111111 0.0137512156643644 0.347120438608672 NA NA NA 0 0 0.205907214207822 NA NA NA NA 1354 1762 False False 0 0 0 0 0 0 0 0.529532241014799 0.0590463511413706 2.25377629033936 0 0 0.000974387411009493 0.99900286675807 0.998381221815451 0.999429948179957 52 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Ala440Thr rpsA_p.Ala440Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 163 7 4246 16815 0.0369698344295758 0.0315955022033961 0.0429681086332695 0.999583878254666 0.99914281931165 0.999832681632407 0.958823529411764 0.91700346354596 0.9832871285152 0 0 0.975 0 0 0.409616397225003 0 0 154.087435296031 1 1273 1830 False False 92.2160352600767 43.7050448565052 233.633609118201 0 0 0.000868412032155956 0.999583878254666 0.99914281931165 0.999832681632407 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 161 7 3625 16039 0.0425250924458531 0.0363210088677435 0.0494472014044384 0.999563754206656 0.999101374817905 0.99982458915172 0.958333333333333 0.91603749518913 0.983086231470627 0 0 0.975 0 0 0.409616397225003 0 0 172.106899549262 1 554.5 1762 False False 0 0 0 0 0 0 0 101.764689655172 48.23897007416 256.950801327074 0 0 0.001017104316781 0.999563754206656 0.999101374817905 0.99982458915172 69 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Ala460Thr rpsA_p.Ala460Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1426 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1367 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Ala460Val rpsA_p.Ala460Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1377 1830 False False Inf 0.716637886286628 Inf 0 0 0.000836699794980095 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1321 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0 0 0.000974387411009493 1 0.999770132403032 1 4 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Ala468Ser rpsA_p.Ala468Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Ala472Thr rpsA_p.Ala472Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 4409 16817 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.16390782018879 0.590722354627394 560.5 1830 False False 0 0 4.16390782018879 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 3786 16041 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.62556638995023 0.590888399193514 509 1762 False False 0 0 0 0 0 0 0 0 0 4.62556638995023 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Ala478Val rpsA_p.Ala478Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1401 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1341 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Ala65Pro rpsA_p.Ala65Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Arg111His rpsA_p.Arg111His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1385 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1329 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Arg187Cys rpsA_p.Arg187Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1402 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1342 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Arg329Leu rpsA_p.Arg329Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1432 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Arg356Cys rpsA_p.Arg356Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1438 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1377 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Arg443Cys rpsA_p.Arg443Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Asn221Asp rpsA_p.Asn221Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1418 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1359 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Asn34Thr rpsA_p.Asn34Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1442 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1380 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Asn389Thr rpsA_p.Asn389Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Asn77Lys rpsA_p.Asn77Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 4409 16817 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.16390782018879 0.590722354627394 560.5 1830 False False 0 0 4.16390782018879 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 3786 16041 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.62556638995023 0.590888399193514 509 1762 False False 0 0 0 0 0 0 0 0 0 4.62556638995023 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Asp123Ala rpsA_p.Asp123Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 14 0 14 4 16 4405 16806 0.000907235200725788 0.000247244623732042 0.00232123869101376 0.999048864582094 0.998455873997109 0.999456249287664 0.2 0.0573339970500327 0.436614002996668 0 0 0.231635761650116 0 0 0.205907214207822 0 0 1.15070051507915 0.089983615527421 297 1830 False False 0.953802497162315 0.231929397401602 2.95881934090962 0 0 0.000837079522337697 0.999048864582094 0.998455873997109 0.999456249287664 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 14 0 14 4 16 3782 16030 0.00105652403592181 0.000287939890647285 0.00270289202199999 0.99900286675807 0.998381221815451 0.999429948179957 0.2 0.0573339970500327 0.436614002996668 0 0 0.231635761650116 0 0 0.205907214207822 0 0 1.27847615357717 0.0870664597248758 276 1762 False False 0 0 0 0 0 0 0 1.05962453728186 0.257631211649932 3.28730403273548 0 0 0.000974902436017582 0.99900286675807 0.998381221815451 0.999429948179957 51 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Asp123Glu rpsA_p.Asp123Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Asp15Ala rpsA_p.Asp15Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 1 4406 16821 0.000680426400544341 0.000140342268876931 0.00198719451371054 0.99994055403638 0.999668833292177 0.99999849495964 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 1453 1830 False False 11.4532455742169 0.919224933680734 599.12689591493 0 0 0.000836889615584862 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1389 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Asp15Gly rpsA_p.Asp15Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 2 4408 16820 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999881108072762 0.999570588169705 0.999985601311719 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1393 1830 False False 1.9078947368421 0.0323314320919459 36.6634061310851 0 0 0.000836510060464794 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1336 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 13 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Asp15Tyr rpsA_p.Asp15Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1374 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1318 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Asp160Ala rpsA_p.Asp160Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 3 1 4406 16821 0.000680426400544341 0.000140342268876931 0.00198719451371054 0.99994055403638 0.999668833292177 0.99999849495964 0.75 0.194120449683243 0.99369053679029 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0978686939929467 Inf 0.207603165630299 331 1830 False False 11.4532455742169 0.919224933680734 599.12689591493 0.00022691173133651 5.74489114141023e-06 0.00126361569125499 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 1 3784 16045 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999937679172379 0.999652820032955 0.999998422174497 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 1349 1762 False False 0 0 0 0 0 0 0 8.48044397463002 0.441282441622781 498.676520130596 0 0 0.000974387411009493 0.999937679172379 0.999652820032955 0.999998422174497 3 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Asp256Gly rpsA_p.Asp256Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1408 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1350 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 3 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Asp27Asn rpsA_p.Asp27Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1403 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1344 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Asp27Gly rpsA_p.Asp27Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Asp368Asn rpsA_p.Asp368Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1386 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1330 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Asp368Glu rpsA_p.Asp368Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1380 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1324 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Asp374Asn rpsA_p.Asp374Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1433 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1372 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Asp37Gly rpsA_p.Asp37Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 4408 16821 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 148.49048666616 1 897.5 1830 False False 3.81601633393829 0.0486026416232846 298.829108180248 0 0 0.000836510060464794 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 3785 16045 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 164.911820358037 1 927 1762 False False 0 0 0 0 0 0 0 4.23910171730515 0.0539892730999128 331.863925136224 0 0 0.000974130102511011 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Asp385Gly rpsA_p.Asp385Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1437 1830 False False Inf 1.57702975056642 Inf 0 0 0.000836889615584862 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1376 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Asp447Gly rpsA_p.Asp447Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Asp54Ala rpsA_p.Asp54Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Asp75Gly rpsA_p.Asp75Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 32 4409 16790 0 0 0.000836320411980403 0.998097729164189 0.997315612940588 0.99869849551898 0 0 0.108881160679352 NA NA NA 0 0 0.108881160679352 NA NA NA NA 1434 1830 False False 0 0 0.465549904466373 0 0 0.000836320411980403 0.998097729164189 0.997315612940588 0.99869849551898 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 32 3786 16014 0 0 0.000973872929872615 0.998005733516141 0.997185846734806 0.998635535618626 0 0 0.108881160679352 NA NA NA 0 0 0.108881160679352 NA NA NA NA 1373 1762 False False 0 0 0 0 0 0 0 0 0 0.517131841158514 0 0 0.000973872929872615 0.998005733516141 0.997185846734806 0.998635535618626 3 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Asp84Asn rpsA_p.Asp84Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Gln162Pro rpsA_p.Gln162Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1435 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1374 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Gln207Lys rpsA_p.Gln207Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Gln410Arg rpsA_p.Gln410Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.23555131695149 1 1273 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 10.2590571436125 1 554.5 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Gln431Arg rpsA_p.Gln431Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Gln469Glu rpsA_p.Gln469Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 5 4409 16817 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 0 0 0.521823750104981 0 0 0.975 0 0 0.521823750104981 0 0 148.421667054835 1 1273 1830 False False 0 0 4.16390782018879 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 5 3786 16041 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 0 0 0.521823750104981 0 0 0.975 0 0 0.521823750104981 0 0 164.82738115497 1 927 1762 False False 0 0 0 0 0 0 0 0 0 4.62556638995023 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Glu121Asp rpsA_p.Glu121Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 7 4407 16815 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.999583878254666 0.99914281931165 0.999832681632407 0.222222222222222 0.0281449734778982 0.600093573716312 1 0.025 1 0.125 0.0031597235312519 0.526509670875206 Inf 0.0978115898224894 Inf 0.207699194270367 457 1830 False False 1.09014878926383 0.110443394403449 5.72897307878473 0.000226860254083484 5.74358785768897e-06 0.0012633291757201 0.999583878254666 0.99914281931165 0.999832681632407 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 7 3784 16039 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999563754206656 0.999101374817905 0.99982458915172 0.222222222222222 0.0281449734778982 0.600093573716312 1 0.025 1 0.125 0.0031597235312519 0.526509670875206 Inf 0.108654198144757 Inf 0.190930185633575 441 1762 False False 0 0 0 0 0 0 0 1.21103896103896 0.122676568824873 6.36418838380077 0.000264200792602377 6.68896256519433e-06 0.00147114392376758 0.999563754206656 0.999101374817905 0.99982458915172 6 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Glu154Gly rpsA_p.Glu154Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1419 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1360 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 3 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Glu197Lys rpsA_p.Glu197Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 1 6 4408 16816 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999643324218285 0.999223829869625 0.999869095386533 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.24103762738456 0.355898403474894 492.5 1830 False False 0.635813672111312 0.0138232628839914 5.24325822004213 0 0 0.000836510060464794 0.999643324218285 0.999223829869625 0.999869095386533 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 1 6 3785 16040 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999626075034276 0.999186301793093 0.999862764161372 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.6007743968973 0.602770739158116 520 1762 False False 0 0 0 0 0 0 0 0.706296785557023 0.0153546142757778 5.82369259713769 0 0 0.000974130102511011 0.999626075034276 0.999186301793093 0.999862764161372 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Glu367Lys rpsA_p.Glu367Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1381 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1325 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Glu372Lys rpsA_p.Glu372Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1371 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1315 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Glu386Ala rpsA_p.Glu386Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Glu386Lys rpsA_p.Glu386Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1447 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1384 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Glu394Ala rpsA_p.Glu394Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1439 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1378 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Glu394Gly rpsA_p.Glu394Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Glu408Lys rpsA_p.Glu408Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Glu415Asp rpsA_p.Glu415Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Glu422Ala rpsA_p.Glu422Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Glu60Gln rpsA_p.Glu60Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Glu67Asp rpsA_p.Glu67Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 2 4406 16820 0.000680426400544341 0.000140342268876931 0.00198719451371054 0.999881108072762 0.999570588169705 0.999985601311719 0.6 0.146632799634673 0.947255049473683 0 0 0.975 0 0 0.841886116991581 0 0 148.54892330925 1 1273 1830 False False 5.72628234226055 0.655677739135472 68.675028521871 0 0 0.000836889615584862 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 2 3783 16044 0.000792393026941363 0.000163440311798119 0.00231394549068866 0.999875358344758 0.999549824781286 0.999984904960856 0.6 0.146632799634673 0.947255049473683 0 0 0.975 0 0 0.841886116991581 0 0 164.988524968396 1 927 1762 False False 0 0 0 0 0 0 0 6.36161776367961 0.728392675067714 76.0575760881352 0 0 0.000974644855475749 0.999875358344758 0.999549824781286 0.999984904960856 10 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Gly17Ala rpsA_p.Gly17Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Gly229Cys rpsA_p.Gly229Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 1 4407 16821 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.99994055403638 0.999668833292177 0.99999849495964 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 1420 1830 False False 7.63376446562287 0.397281353658273 449.052313013199 0 0 0.000836699794980095 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Gly316Val rpsA_p.Gly316Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Gly36Ala rpsA_p.Gly36Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1382 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1326 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 3 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.His247Leu rpsA_p.His247Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 4409 16817 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 5.77993884793644 0.58676144625344 535 1830 False False 0 0 4.16390782018879 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 5 3786 16041 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 6.42069813886719 1 927 1762 False False 0 0 0 0 0 0 0 0 0 4.62556638995023 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.His322Tyr rpsA_p.His322Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 4405 16822 0.000907235200725788 0.000247244623732042 0.00232123869101376 1 0.999780735048249 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 1389 1830 False False Inf 2.51959224712996 Inf 0 0 0.000837079522337697 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1332 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0 0 0.000974387411009493 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.His425Arg rpsA_p.His425Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1443 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Ile165Leu rpsA_p.Ile165Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Ile173Thr rpsA_p.Ile173Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1394 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Ile26Met rpsA_p.Ile26Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1390 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1333 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Ile296Val rpsA_p.Ile296Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1375 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1319 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 11 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Ile30Val rpsA_p.Ile30Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Ile391Val rpsA_p.Ile391Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1391 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1334 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Ile55Val rpsA_p.Ile55Val 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1440 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1379 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 3 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Ile70Leu rpsA_p.Ile70Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 50 4409 16772 0 0 0.000836320411980403 0.997027701819046 0.996083250231888 0.997793122630118 0 0 0.0711217364641976 NA NA NA 0 0 0.0711217364641976 NA NA NA NA 1414 1830 False True 0 0 0.291437081168157 0 0 0.000836320411980403 0.997027701819046 0.996083250231888 0.997793122630118 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 47 3786 15999 0 0 0.000973872929872615 0.997070921101832 0.996106827985343 0.997847053278508 0 0 0.0754857336910586 NA NA NA 0 0 0.0754857336910586 NA NA NA NA 1355 1762 False True 1 1 1 0 0 0 0 0 0 0.345251047055164 0 0 0.000973872929872615 0.997070921101832 0.996106827985343 0.997847053278508 42 5) Not assoc w R New NotAwR yes 5 +Pyrazinamide rpsA p.Ile70Thr rpsA_p.Ile70Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Leu102Val rpsA_p.Leu102Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Leu144Pro rpsA_p.Leu144Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1409 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Leu161Met rpsA_p.Leu161Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.23555131695149 1 1273 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 10.2590571436125 1 554.5 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 3 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Leu161Val rpsA_p.Leu161Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1427 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Leu404Phe rpsA_p.Leu404Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1378 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1322 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Leu477fs rpsA_p.Leu477fs 2 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1415 1830 False False Inf 1.57702975056642 Inf 0 0 0.000836889615584862 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1356 1762 False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf 0 0 0.000974644855475749 1 0.999770132403032 1 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Leu89Arg rpsA_p.Leu89Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Lys122Met rpsA_p.Lys122Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1397 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1338 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 3 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Lys127Asn rpsA_p.Lys127Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 3 4408 16819 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999821662109142 0.999478910338162 0.999963220929399 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1410 1830 False False 1.2718542044767 0.0242215257537785 15.8425197757275 0 0 0.000836510060464794 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 3 3785 16043 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999813037517138 0.999453714469566 0.999961442181588 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1351 1762 False False 0 0 0 0 0 0 0 1.41285777190664 0.0269058536042688 17.5998124179982 0 0 0.000974130102511011 0.999813037517138 0.999453714469566 0.999961442181588 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Lys167Asn rpsA_p.Lys167Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 9 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Lys167Glu rpsA_p.Lys167Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Lys300Glu rpsA_p.Lys300Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 3 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Lys409Arg rpsA_p.Lys409Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1454 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1390 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Lys409Asn rpsA_p.Lys409Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Lys434Glu rpsA_p.Lys434Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Lys458Thr rpsA_p.Lys458Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 4 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Lys45Gln rpsA_p.Lys45Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1372 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1316 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Lys45Glu rpsA_p.Lys45Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 3 4 4406 16818 0.000680426400544341 0.000140342268876931 0.00198719451371054 0.999762216145523 0.999391291831884 0.999935208223951 0.428571428571428 0.0989882784425078 0.815948432359917 0 0 0.841886116991581 0 0 0.602364635616474 0 0 20.3340769157231 1 1273 1830 False False 2.86280072628234 0.41917700195722 16.9258510172791 0 0 0.000836889615584862 0.999762216145523 0.999391291831884 0.999935208223951 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Lys476fs rpsA_p.Lys476fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 148.448081147381 1 1273 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 164.858125974995 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Lys476* rpsA_p.Lys476* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1455 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1391 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Lys71Thr rpsA_p.Lys71Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Met267Leu rpsA_p.Met267Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Met432_Ala438delinsThr rpsA_p.Met432_Ala438delinsThr 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Met432Thr rpsA_p.Met432Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 190 571 4219 16251 0.0430936720344749 0.0372907723000074 0.049511142067338 0.96605635477351 0.963208341494346 0.968741709799955 0.249671484888304 0.219282466747152 0.282014257037245 NA NA NA 0 0 0.00643956091663975 NA NA NA NA NA NA False True 1.28170493833873 1.0780900699923 1.51850970724949 0 0 0.000873967110582959 0.96605635477351 0.963208341494346 0.968741709799955 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 158 545 3628 15501 0.0417326994189117 0.0355867637332101 0.048598072243734 0.966035148946778 0.963115472998826 0.968784252369793 0.22475106685633 0.194392335978758 0.257439837569692 NA NA NA 0 0 0.00674573087013249 NA NA NA NA NA NA False True 0 0 1 0 0 0 1 1.23866259369025 1.02714421791475 1.48706746605834 0 0 0.00101626369882198 0.966035148946778 0.963115472998826 0.968784252369793 900 Literature evidence (PMID 32143680) 4) Not assoc w R - Interim New NotAwRI yes Lit. (PMID 32143680) 5 +Pyrazinamide rpsA p.Pro163Ser rpsA_p.Pro163Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 5 4408 16817 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999702770181904 0.999306502227134 0.999903483469113 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1429 1830 False False 0.763021778584392 0.0161324685427033 6.82117624035202 0 0 0.000836510060464794 0.999702770181904 0.999306502227134 0.999903483469113 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 5 3785 16041 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999688395861897 0.99927297097682 0.999898815491092 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1369 1762 False False 0 0 0 0 0 0 0 0.847608982826948 0.0179160496983802 7.57805461545705 0 0 0.000974130102511011 0.999688395861897 0.99927297097682 0.999898815491092 15 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Pro298Ser rpsA_p.Pro298Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 4408 16821 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 148.49048666616 1 897.5 1830 False False 3.81601633393829 0.0486026416232846 298.829108180248 0 0 0.000836510060464794 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 3785 16045 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 164.911820358037 1 927 1762 False False 0 0 0 0 0 0 0 4.23910171730515 0.0539892730999128 331.863925136224 0 0 0.000974130102511011 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Pro306Ser rpsA_p.Pro306Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1416 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1357 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Pro375Ser rpsA_p.Pro375Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1400 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Pro4Leu rpsA_p.Pro4Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Pro76Leu rpsA_p.Pro76Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Ser18Tyr rpsA_p.Ser18Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1441 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Ser19Arg rpsA_p.Ser19Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Ser249Ala rpsA_p.Ser249Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Ser452Asn rpsA_p.Ser452Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1373 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1317 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 3 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Ser81Tyr rpsA_p.Ser81Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Ser8Leu rpsA_p.Ser8Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1404 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1345 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Ter482ext*? rpsA_p.Ter482ext*? 2 stop_lost (see "Genomic_coordinates" sheet) 0 0 0 0 41 2 4368 16820 0.00929916080743932 0.00668126910049186 0.0125944207000321 0.999881108072762 0.999570588169705 0.999985601311719 0.953488372093023 0.841888541691302 0.994316743021252 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1411 1830 False False 78.9400183150183 20.4938421836275 674.309143741458 0 0 0.000844167174790384 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 3 1 3783 16045 0.000792393026941363 0.000163440311798119 0.00231394549068866 0.999937679172379 0.999652820032955 0.999998422174497 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 1352 1762 False False 0 0 0 0 0 0 0 12.7240285487708 1.02115021686679 665.307410149575 0 0 0.000974644855475749 0.999937679172379 0.999652820032955 0.999998422174497 137 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Thr115Ala rpsA_p.Thr115Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Thr194Ala rpsA_p.Thr194Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Thr210Ala rpsA_p.Thr210Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1444 1830 False False Inf 1.57702975056642 Inf 0 0 0.000836889615584862 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1381 1762 False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf 0 0 0.000974644855475749 1 0.999770132403032 1 10 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Thr259Ile rpsA_p.Thr259Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1449 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1385 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Thr42Ala rpsA_p.Thr42Ala 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1423 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1363 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 5 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Thr59Ala rpsA_p.Thr59Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Thr5Ala rpsA_p.Thr5Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1421 1830 False False Inf 1.57702975056642 Inf 0 0 0.000836889615584862 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1361 1762 False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf 0 0 0.000974644855475749 1 0.999770132403032 1 7 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Thr5Pro rpsA_p.Thr5Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Thr92Ile rpsA_p.Thr92Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1430 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1370 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Trp113Leu rpsA_p.Trp113Leu 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 4408 16821 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1395 1830 False False 3.81601633393829 0.0486026416232846 298.829108180248 0 0 0.000836510060464794 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 3785 16045 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1337 1762 False False 0 0 0 0 0 0 0 4.23910171730515 0.0539892730999128 331.863925136224 0 0 0.000974130102511011 0.999937679172379 0.999652820032955 0.999998422174497 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Trp190Arg rpsA_p.Trp190Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1431 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1371 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Tyr369Cys rpsA_p.Tyr369Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 2 3 4407 16819 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.999821662109142 0.999478910338162 0.999963220929399 0.4 0.0527449505263169 0.853367200365326 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.3306797725488 1 1273 1830 False False 2.5442856062325 0.212429984141661 22.2163543346012 0 0 0.000836699794980095 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 2 3 3784 16043 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999813037517138 0.999453714469566 0.999961442181588 0.4 0.0527449505263169 0.853367200365326 0 0 0.841886116991581 0 0 0.707598226178713 0 0 22.5813800991657 1 927 1762 False False 0 0 0 0 0 0 0 2.82646229739253 0.235979261609975 24.6811314932427 0 0 0.000974387411009493 0.999813037517138 0.999453714469566 0.999961442181588 8 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Tyr390Cys rpsA_p.Tyr390Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1387 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Val126Phe rpsA_p.Val126Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1396 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Val134dup rpsA_p.Val134dup 2 inframe_insertion (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1383 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1327 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Val183Met rpsA_p.Val183Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 4407 16821 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.99994055403638 0.999668833292177 0.99999849495964 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 148.524102705736 1 1273 1830 False False 7.63376446562287 0.397281353658273 449.052313013199 0 0 0.000836699794980095 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 3784 16045 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999937679172379 0.999652820032955 0.999998422174497 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 164.955289378195 1 554.5 1762 False False 0 0 0 0 0 0 0 8.48044397463002 0.441282441622781 498.676520130596 0 0 0.000974387411009493 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Val215Ile rpsA_p.Val215Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1376 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1320 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 3 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Val226Ala rpsA_p.Val226Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Val254Gly rpsA_p.Val254Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 3 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Val258Ile rpsA_p.Val258Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Val260Ile rpsA_p.Val260Ile 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 35 79 4374 16743 0.00793830800635064 0.00553537226062617 0.0110231268596098 0.995303768874093 0.994150482297722 0.996280239046638 0.307017543859649 0.224038423861158 0.400313690546808 NA NA NA 0 0 0.045621252758611 NA NA NA NA 1388 1830 False False 1.6958813008977 1.10352312105007 2.55914556133291 0 0 0.000843009683358092 0.995303768874093 0.994150482297722 0.996280239046638 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 35 79 3751 15967 0.0092445853143159 0.00644740093127529 0.0128337348087054 0.995076654617973 0.993867765873313 0.996100260965179 0.307017543859649 0.224038423861158 0.400313690546808 NA NA NA 0 0 0.045621252758611 NA NA NA NA 1331 1762 False False 0 0 0 0 0 0 0 1.88589371948071 1.22694094207348 2.84649425440238 0 0 0.000982955519792183 0.995076654617973 0.993867765873313 0.996100260965179 780 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Val265Ile rpsA_p.Val265Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1445 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1382 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Val297Ala rpsA_p.Val297Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Val321Met rpsA_p.Val321Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1405 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1346 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Val62Leu rpsA_p.Val62Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 148.448081147381 1 1273 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 164.858125974995 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Val80Phe rpsA_p.Val80Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1446 1830 False False Inf 0.716637886286628 Inf 0 0 0.000836699794980095 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1383 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0 0 0.000974387411009493 1 0.999770132403032 1 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide rpsA p.Val86Ile rpsA_p.Val86Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1417 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1358 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv1258c c.1029T>C Rv1258c_c.1029T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 16 392 4393 16430 0.00362894080290315 0.00207563231786599 0.00588650013813049 0.976697182261324 0.97430354834833 0.978923977180542 0.0392156862745098 0.0225784433233727 0.0629038637242065 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.152654733643969 0.0863058731018552 0.251416542230451 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 16 390 3770 15656 0.00422609614368726 0.00241744983392875 0.00685386626076289 0.975694877227969 0.973193002054042 0.978022204404414 0.0394088669950738 0.0226904880608929 0.0632098693726906 NA NA NA NA NA NA NA NA NA NA NA NA False True 1 1 1 0 0 0 0 0.170370672651839 0.096292492538065 0.280649387046862 NA NA NA NA NA NA 398 5) Not assoc w R Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.1038C>T Rv1258c_c.1038C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.103T>C Rv1258c_c.103T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 12 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.1047C>T Rv1258c_c.1047C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.1062G>A Rv1258c_c.1062G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.1065G>A Rv1258c_c.1065G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0978301145652783 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.1083G>A Rv1258c_c.1083G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.1086G>A Rv1258c_c.1086G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.1092G>A Rv1258c_c.1092G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.1137G>T Rv1258c_c.1137G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.1152A>G Rv1258c_c.1152A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.1161C>T Rv1258c_c.1161C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.1176G>T Rv1258c_c.1176G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 4408 16821 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.81601633393829 0.0486026416232846 298.829108180248 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 3785 16045 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.23910171730515 0.0539892730999128 331.863925136224 NA NA NA NA NA NA 25 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.1200G>T Rv1258c_c.1200G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.1203C>G Rv1258c_c.1203C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0978301145652783 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.1209G>A Rv1258c_c.1209G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.23555131695149 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.2590571436125 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.120C>T Rv1258c_c.120C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.1230C>T Rv1258c_c.1230C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.1251G>A Rv1258c_c.1251G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.129G>A Rv1258c_c.129G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0978301145652783 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.162G>T Rv1258c_c.162G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.165G>A Rv1258c_c.165G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.23555131695149 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.2590571436125 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.168G>A Rv1258c_c.168G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.-16T>A Rv1258c_c.-16T>A 2 upstream_gene_variant 1407356 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c c.-16T>C Rv1258c_c.-16T>C 2 upstream_gene_variant 1407356 1 3 1 2 3 2 4406 16820 0.000680426400544341 0.000140342268876931 0.00198719451371054 0.999881108072762 0.999570588169705 0.999985601311719 0.6 0.146632799634673 0.947255049473683 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 1.90876078075351 0.0323461049339473 36.6802457819791 0.502459778683023 518 1830 False False 5.72628234226055 0.655677739135472 68.675028521871 0.00022691173133651 5.74489114141023e-06 0.00126361569125499 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 2 2 3784 16044 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999875358344758 0.999549824781286 0.999984904960856 0.5 0.067585986488543 0.932414013511457 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 2.11997885835095 0.0359241175697613 40.7303511527588 0.470274327371684 487.5 1762 False False 0 0 0 0 0 0 0 4.2399577167019 0.307210542317908 58.5302826936734 0.000264200792602377 6.68896256519433e-06 0.00147114392376758 0.999875358344758 0.999549824781286 0.999984904960856 13 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv1258c c.177G>A Rv1258c_c.177G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.186C>T Rv1258c_c.186C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.198C>T Rv1258c_c.198C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.207C>T Rv1258c_c.207C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.-22G>C Rv1258c_c.-22G>C 2 upstream_gene_variant 1407362 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c c.234C>T Rv1258c_c.234C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.-23C>T Rv1258c_c.-23C>T 2 upstream_gene_variant 1407363 1 1 0 1 3 1 4406 16821 0.000680426400544341 0.000140342268876931 0.00198719451371054 0.99994055403638 0.999668833292177 0.99999849495964 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 148.557733969102 1 1273 1830 False False 11.4532455742169 0.919224933680734 599.12689591493 0 0 0.000836889615584862 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 1 3783 16045 0.000792393026941363 0.000163440311798119 0.00231394549068866 0.999937679172379 0.999652820032955 0.999998422174497 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 164.998781320348 1 927 1762 False False 0 0 0 0 0 0 0 12.7240285487708 1.02115021686679 665.307410149575 0 0 0.000974644855475749 0.999937679172379 0.999652820032955 0.999998422174497 12 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c c.24G>A Rv1258c_c.24G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.-25G>T Rv1258c_c.-25G>T 2 upstream_gene_variant 1407365 NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1797 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1729 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv1258c c.271C>T Rv1258c_c.271C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.276G>A Rv1258c_c.276G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.279G>A Rv1258c_c.279G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 23 4408 16799 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.998632742836761 0.997949144944278 0.999133084996422 0.0416666666666666 0.00105435244546974 0.211201683456973 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.165696756884715 0.00402521619757175 1.02100598550639 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 23 3785 16023 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.998566620964726 0.997849999215428 0.99909115045139 0.0416666666666666 0.00105435244546974 0.211201683456973 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.184056056515995 0.00447056088625372 1.13425500620465 NA NA NA NA NA NA 24 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.279G>T Rv1258c_c.279G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.-30G>A Rv1258c_c.-30G>A 2 upstream_gene_variant 1407370 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1814 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1746 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c c.-33A>T Rv1258c_c.-33A>T 2 upstream_gene_variant 1407373 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv1258c c.354G>A Rv1258c_c.354G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 4408 16821 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.81601633393829 0.0486026416232846 298.829108180248 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 3785 16045 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.23910171730515 0.0539892730999128 331.863925136224 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.-36C>T Rv1258c_c.-36C>T 2 upstream_gene_variant 1407376 1 3 0 3 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.23555131695149 1 1273 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 10.2590571436125 1 554.5 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c c.-36delC Rv1258c_c.-36delC 2 upstream_gene_variant 1407375 1 3 0 3 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.23555131695149 1 1273 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 10.2590571436125 1 554.5 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 1 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c c.378G>A Rv1258c_c.378G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.384G>A Rv1258c_c.384G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.390G>A Rv1258c_c.390G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.3G>A Rv1258c_c.3G>A 2 initiator_codon_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.23555131695149 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.2590571436125 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.-41G>A Rv1258c_c.-41G>A 2 upstream_gene_variant 1407381 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv1258c c.426C>T Rv1258c_c.426C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.456G>A Rv1258c_c.456G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.459C>A Rv1258c_c.459C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.498G>A Rv1258c_c.498G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.23555131695149 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.2590571436125 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.504T>A Rv1258c_c.504T>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0978301145652783 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.513C>T Rv1258c_c.513C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.528T>C Rv1258c_c.528T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 19 2 4390 16820 0.00430936720344749 0.0025964540708268 0.00672146538628393 0.999881108072762 0.999570588169705 0.999985601311719 0.904761904761904 0.696225593086075 0.988250682115554 NA NA NA NA NA NA NA NA NA NA NA NA False False 36.3986332574031 8.77361533359231 322.205671988544 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 19 1 3767 16045 0.00501848917062863 0.00302408120608821 0.00782594556552751 0.999937679172379 0.999652820032955 0.999998422174497 0.95 0.751267237227972 0.99873491050205 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 80.9277940005309 12.857200096361 3300.32266281989 NA NA NA NA NA NA 31 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.-52G>A Rv1258c_c.-52G>A 2 upstream_gene_variant 1407392 NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1790 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1722 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv1258c c.531C>G Rv1258c_c.531C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.-54C>G Rv1258c_c.-54C>G 2 upstream_gene_variant 1407394 NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1815 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1747 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv1258c c.555C>T Rv1258c_c.555C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.612G>A Rv1258c_c.612G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0978301145652783 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.666G>A Rv1258c_c.666G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 4408 16821 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.81601633393829 0.0486026416232846 298.829108180248 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 3785 16045 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.23910171730515 0.0539892730999128 331.863925136224 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.697C>T Rv1258c_c.697C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.738G>A Rv1258c_c.738G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.753C>T Rv1258c_c.753C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.792G>A Rv1258c_c.792G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.807C>G Rv1258c_c.807C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.837C>T Rv1258c_c.837C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.846T>G Rv1258c_c.846T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.849C>A Rv1258c_c.849C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.852C>T Rv1258c_c.852C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.882G>A Rv1258c_c.882G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.882G>C Rv1258c_c.882G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0978301145652783 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.-8C>T Rv1258c_c.-8C>T 2 upstream_gene_variant 1407348 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1828 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1760 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 10 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c c.900G>A Rv1258c_c.900G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.918G>C Rv1258c_c.918G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.927G>A Rv1258c_c.927G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.930A>G Rv1258c_c.930A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 4408 16821 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.81601633393829 0.0486026416232846 298.829108180248 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 3785 16045 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.23910171730515 0.0539892730999128 331.863925136224 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.942C>T Rv1258c_c.942C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.960G>A Rv1258c_c.960G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.967C>T Rv1258c_c.967C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.972G>A Rv1258c_c.972G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.972G>T Rv1258c_c.972G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.975C>T Rv1258c_c.975C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.978A>G Rv1258c_c.978A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 4409 16817 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.16390782018879 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 5 3786 16041 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.62556638995023 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.981C>T Rv1258c_c.981C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 2 4407 16820 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.999881108072762 0.999570588169705 0.999985601311719 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.8166553210801 0.276553001924986 52.6392074577436 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 3785 16044 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999875358344758 0.999549824781286 0.999984904960856 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.11941875825627 0.0359146288488272 40.7195918479678 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c c.99G>A Rv1258c_c.99G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv1258c deletion Rv1258c_deletion 2 feature_ablation (see "Genomic_coordinates" sheet) NA 0 0 0 0 4 4409 16818 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1824 1830 False False 0 0 5.78028251232769 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 4 3786 16042 0 0 0.000973872929872615 0.999750716689517 0.999361859844744 0.999932074644789 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1756 1762 False False 0 0 0 0 0 0 0 0 0 6.42109836734015 0 0 0.000973872929872615 0.999750716689517 0.999361859844744 0.999932074644789 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv1258c LoF Rv1258c_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 2739 227 2512 1980 3093 2429 13729 0.449081424359265 0.434323888712412 0.463906471840213 0.816133634526215 0.810195591392544 0.821962171316522 0.39030159668835 0.376845648832359 0.403883896415916 0.0828769623950346 0.0728195215565355 0.0938359506421281 0.0683734939759036 0.0600209656661892 0.0774955959253038 0.510760863294637 0.440939169544094 0.589483770200946 3.35918663140235e-23 22 1830 True False 3.618234084668 3.36765366734905 3.88688992075373 0.0854668674698795 0.0751075067464906 0.0967501905237643 0.816133634526215 0.810195591392544 0.821962171316522 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2631 215 2416 1921 2957 1865 13089 0.507395668251452 0.491338048929117 0.523441860400307 0.815717312725913 0.809630143919458 0.821689813464905 0.39380893808938 0.380062247279517 0.407682851133175 0.0817179779551501 0.0715305057268196 0.0928471601202544 0.067780580075662 0.0592769893768491 0.0770912299602962 0.624552802585089 0.536272158758173 0.724628148741559 6.49106354589544e-11 47 1762 True False 0 0 0 0 0 0 0 4.5593577651431 4.22592303488539 4.91899059990126 0.103365384615384 0.0906077305392909 0.117252712542003 0.815717312725913 0.809630143919458 0.821689813464905 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv1258c p.Ala113Val Rv1258c_p.Ala113Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1768 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1700 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 2 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Ala115fs Rv1258c_p.Ala115fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1819 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1751 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv1258c p.Ala123Val Rv1258c_p.Ala123Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Ala135Thr Rv1258c_p.Ala135Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Ala148Thr Rv1258c_p.Ala148Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 148.448081147381 1 1273 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 164.858125974995 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 2 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Ala166Thr Rv1258c_p.Ala166Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Ala178Val Rv1258c_p.Ala178Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1798 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1730 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 2 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Ala187Thr Rv1258c_p.Ala187Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Ala19Val Rv1258c_p.Ala19Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1805 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1737 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Ala237Val Rv1258c_p.Ala237Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 4409 16816 0 0 0.000836320411980403 0.999643324218285 0.999223829869625 0.999869095386533 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.24030155506377 0.355876504746108 489.5 1830 False False 0 0 3.24030155506377 0 0 0.000836320411980403 0.999643324218285 0.999223829869625 0.999869095386533 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 3786 16040 0 0 0.000973872929872615 0.999626075034276 0.999186301793093 0.999862764161372 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.59982301180526 0.602786000899522 522.5 1762 False False 0 0 0 0 0 0 0 0 0 3.59982301180526 0 0 0.000973872929872615 0.999626075034276 0.999186301793093 0.999862764161372 18 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Ala266Val Rv1258c_p.Ala266Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Ala275Val Rv1258c_p.Ala275Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 4409 16817 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.16390782018879 0.590722354627394 560.5 1830 False False 0 0 4.16390782018879 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 3786 16041 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.62556638995023 0.590888399193514 509 1762 False False 0 0 0 0 0 0 0 0 0 4.62556638995023 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Ala294Val Rv1258c_p.Ala294Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1822 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1754 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv1258c p.Ala29Glu Rv1258c_p.Ala29Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 4408 16821 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1772 1830 False False 3.81601633393829 0.0486026416232846 298.829108180248 0 0 0.000836510060464794 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 3785 16045 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1704 1762 False False 0 0 0 0 0 0 0 4.23910171730515 0.0539892730999128 331.863925136224 0 0 0.000974130102511011 0.999937679172379 0.999652820032955 0.999998422174497 24 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Ala301Thr Rv1258c_p.Ala301Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1779 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1711 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Ala358Thr Rv1258c_p.Ala358Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Ala367Gly Rv1258c_p.Ala367Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1783 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1715 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Ala367Thr Rv1258c_p.Ala367Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 11 0 11 0 11 4409 16811 0 0 0.000836320411980403 0.99934609440019 0.998830284178405 0.999673528922672 0 0 0.284914152918154 0 0 0.284914152918154 0 0 0.284914152918154 0 0 1.51991683293768 0.135362010704541 316.5 1830 False False 0 0 1.51991683293768 0 0 0.000836320411980403 0.99934609440019 0.998830284178405 0.999673528922672 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 0 11 0 11 3786 16035 0 0 0.000973872929872615 0.999314470896173 0.998773730902855 0.999657738248111 0 0 0.284914152918154 0 0 0.284914152918154 0 0 0.284914152918154 0 0 1.68837982812114 0.139257612313174 294.5 1762 False False 0 0 0 0 0 0 0 0 0 1.68837982812114 0 0 0.000973872929872615 0.999314470896173 0.998773730902855 0.999657738248111 43 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Ala367Val Rv1258c_p.Ala367Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1769 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1701 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Ala373Val Rv1258c_p.Ala373Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.23555131695149 1 1273 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 10.2590571436125 1 554.5 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Ala374Pro Rv1258c_p.Ala374Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 20 0 20 0 28 4409 16794 0 0 0.000836320411980403 0.998335513018666 0.997595244490548 0.998893684365631 0 0 0.123436118500263 0 0 0.168433470983085 0 0 0.123436118500263 0 0 0.77191671043426 0.0222603672470893 227 1830 False False 0 0 0.536645015927347 0 0 0.000836320411980403 0.998335513018666 0.997595244490548 0.998893684365631 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 20 0 20 0 28 3786 16018 0 0 0.000973872929872615 0.998255016826623 0.997478993411849 0.998840167868832 0 0 0.123436118500263 0 0 0.168433470983085 0 0 0.123436118500263 0 0 0.85745731256983 0.0216854617919896 209 1762 False False 0 0 0 0 0 0 0 0 0 0.596141506464563 0 0 0.000973872929872615 0.998255016826623 0.997478993411849 0.998840167868832 31 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Ala374Thr Rv1258c_p.Ala374Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv1258c p.Ala374Val Rv1258c_p.Ala374Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Ala378Val Rv1258c_p.Ala378Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Ala394Thr Rv1258c_p.Ala394Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 4407 16821 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.99994055403638 0.999668833292177 0.99999849495964 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 148.524102705736 1 1273 1830 False False 7.63376446562287 0.397281353658273 449.052313013199 0 0 0.000836699794980095 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 3784 16045 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999937679172379 0.999652820032955 0.999998422174497 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 164.955289378195 1 554.5 1762 False False 0 0 0 0 0 0 0 8.48044397463002 0.441282441622781 498.676520130596 0 0 0.000974387411009493 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Ala399Val Rv1258c_p.Ala399Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 4408 16819 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999821662109142 0.999478910338162 0.999963220929399 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.23764632949317 1 1273 1830 False False 1.2718542044767 0.0242215257537785 15.8425197757275 0 0 0.000836510060464794 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 3 3785 16043 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999813037517138 0.999453714469566 0.999961442181588 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 10.2617671351504 1 927 1762 False False 0 0 0 0 0 0 0 1.41285777190664 0.0269058536042688 17.5998124179982 0 0 0.000974130102511011 0.999813037517138 0.999453714469566 0.999961442181588 23 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Ala418Asp Rv1258c_p.Ala418Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Ala41Gly Rv1258c_p.Ala41Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Ala65Thr Rv1258c_p.Ala65Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 1 4 4408 16818 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999762216145523 0.999391291831884 0.999935208223951 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.78159412461106 0.586781479874662 550 1830 False False 0.95383393829401 0.0193637820130019 9.63941079069668 0 0 0.000836510060464794 0.999762216145523 0.999391291831884 0.999935208223951 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 1 4 3785 16042 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999750716689517 0.999361859844744 0.999932074644789 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.42279526569339 1 927 1762 False False 0 0 0 0 0 0 0 1.05957727873183 0.0215096981131212 10.714411563858 0 0 0.000974130102511011 0.999750716689517 0.999361859844744 0.999932074644789 1 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Ala78fs Rv1258c_p.Ala78fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1801 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1733 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Ala78Thr Rv1258c_p.Ala78Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Ala80Val Rv1258c_p.Ala80Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 4409 16818 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.78028251232769 0.586765606596145 543.5 1830 False False 0 0 5.78028251232769 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 3786 16042 0 0 0.000973872929872615 0.999750716689517 0.999361859844744 0.999932074644789 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.42109836734015 1 554.5 1762 False False 0 0 0 0 0 0 0 0 0 6.42109836734015 0 0 0.000973872929872615 0.999750716689517 0.999361859844744 0.999932074644789 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Arg396Trp Rv1258c_p.Arg396Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Arg401Gly Rv1258c_p.Arg401Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv1258c p.Arg401His Rv1258c_p.Arg401His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1816 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1748 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Arg71His Rv1258c_p.Arg71His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Asn151Asp Rv1258c_p.Asn151Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Asn221Ser Rv1258c_p.Asn221Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv1258c p.Asn333Thr Rv1258c_p.Asn333Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1780 1830 False False Inf 0.716637886286628 Inf 0 0 0.000836699794980095 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1712 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0 0 0.000974387411009493 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv1258c p.Asn3Lys Rv1258c_p.Asn3Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1773 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1705 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Asn5fs Rv1258c_p.Asn5fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 2 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Asp125fs Rv1258c_p.Asp125fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1782 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1714 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Asp232Glu Rv1258c_p.Asp232Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1808 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1740 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 7 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv1258c p.Asp23Gly Rv1258c_p.Asp23Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1791 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1723 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv1258c p.Asp23Val Rv1258c_p.Asp23Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 10 0 10 1 24 4408 16798 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.998573296873142 0.997877917781838 0.999085677166006 0.04 0.00101219969931084 0.203516913922414 0 0 0.30849710781876 0 0 0.142473597722525 0 0 1.70085516596133 0.232240740845971 479 1830 False False 0.158783272837265 0.00386406169153894 0.974325947165153 0 0 0.000836510060464794 0.998573296873142 0.997877917781838 0.999085677166006 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 1 24 3785 16022 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.998504300137105 0.997775329312221 0.999041449122186 0.04 0.00101219969931084 0.203516913922414 0 0 0.30849710781876 0 0 0.142473597722525 0 0 1.88943734535705 0.225526366444603 455 1762 False False 0 0 0 0 0 0 0 0.176376045794804 0.00429154374793606 1.08236230283629 0 0 0.000974130102511011 0.998504300137105 0.997775329312221 0.999041449122186 14 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Asp253Glu Rv1258c_p.Asp253Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv1258c p.Asp404Asn Rv1258c_p.Asp404Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Asp67Asn Rv1258c_p.Asp67Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 3 4408 16819 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999821662109142 0.999478910338162 0.999963220929399 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.3260788325813 1 897.5 1830 False False 1.2718542044767 0.0242215257537785 15.8425197757275 0 0 0.000836510060464794 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 3 3785 16043 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999813037517138 0.999453714469566 0.999961442181588 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 22.5754213117106 1 927 1762 False False 0 0 0 0 0 0 0 1.41285777190664 0.0269058536042688 17.5998124179982 0 0 0.000974130102511011 0.999813037517138 0.999453714469566 0.999961442181588 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Asp99Glu Rv1258c_p.Asp99Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv1258c p.Gln206Leu Rv1258c_p.Gln206Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Gln255His Rv1258c_p.Gln255His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Gln329* Rv1258c_p.Gln329* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Gln337Pro Rv1258c_p.Gln337Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 2 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Gln419Arg Rv1258c_p.Gln419Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 148.448081147381 1 1273 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 164.858125974995 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 11 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv1258c p.Gln43His Rv1258c_p.Gln43His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1809 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1741 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Glu194Asp Rv1258c_p.Glu194Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Glu194fs Rv1258c_p.Glu194fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2679 220 2459 1977 3028 2432 13794 0.44840099795872 0.433645982173306 0.463224427837843 0.819997622161455 0.814107039780931 0.825777353624702 0.395004995004995 0.381426376897825 0.408706195594996 0.0821201941022769 0.0719981669676402 0.0931659397596736 0.0677339901477832 0.0593303516097329 0.0769256905103005 0.507447132980886 0.437153646716618 0.586825955127062 4.17229120447133e-23 23 1830 True False 3.70320240257595 3.44602961873716 3.97880135202725 0.0829562594268476 0.0727351019955634 0.0941086773992622 0.819997622161455 0.814107039780931 0.825777353624702 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2572 208 2364 1918 2892 1868 13154 0.506603275224511 0.490545914931988 0.522650432686011 0.819768166521251 0.813731836876566 0.825688349977406 0.398752598752598 0.384876240884109 0.412751976283225 0.0808709175738724 0.070621706111546 0.0920857400255661 0.0670967741935483 0.0585400939385247 0.0764808642317981 0.619579198324619 0.530789778529664 0.720404688371169 5.15620926822435e-11 46 1762 True False 0 0 0 0 0 0 0 4.6701548390154 4.32772972691317 5.03944861707806 0.10019267822736 0.087607220348896 0.113919434166024 0.819768166521251 0.813731836876566 0.825688349977406 10405 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv1258c p.Glu214Asp Rv1258c_p.Glu214Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv1258c p.Glu214Lys Rv1258c_p.Glu214Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1818 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1750 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Glu243Ala Rv1258c_p.Glu243Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 41 4409 16781 0 0 0.000836320411980403 0.997562715491618 0.996694985704893 0.998250412195191 0 0 0.0860438362940284 NA NA NA 0 0 0.0860438362940284 NA NA NA NA NA NA False True 0 0 0.358512715012584 0 0 0.000836320411980403 0.997562715491618 0.996694985704893 0.998250412195191 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 41 3786 16005 0 0 0.000973872929872615 0.997444846067555 0.996535224928996 0.998165772517582 0 0 0.0860438362940284 NA NA NA 0 0 0.0860438362940284 NA NA NA NA NA NA False True 1 1 1 0 0 1 0 0 0 0.398223010624389 0 0 0.000973872929872615 0.997444846067555 0.996535224928996 0.998165772517582 17 Not assoc w R 5) Not assoc w R No change yes 1 +Pyrazinamide Rv1258c p.Glu38Lys Rv1258c_p.Glu38Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Glu402Ala Rv1258c_p.Glu402Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1792 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1724 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Gly207Arg Rv1258c_p.Gly207Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1817 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1749 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv1258c p.Gly229Arg Rv1258c_p.Gly229Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Gly24Asp Rv1258c_p.Gly24Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1774 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1706 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv1258c p.Gly24Cys Rv1258c_p.Gly24Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 14 0 14 1 16 4408 16806 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999048864582094 0.998455873997109 0.999456249287664 0.0588235294117647 0.00148817439126663 0.28688939666722 0 0 0.231635761650116 0 0 0.205907214207822 0 0 1.14991767295409 0.0900284227638016 298 1830 False False 0.23828833938294 0.00568459580523725 1.5346868976765 0 0 0.000836510060464794 0.999048864582094 0.998455873997109 0.999456249287664 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 14 0 14 1 16 3785 16030 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.99900286675807 0.998381221815451 0.999429948179957 0.0588235294117647 0.00148817439126663 0.28688939666722 0 0 0.231635761650116 0 0 0.205907214207822 0 0 1.27746240369879 0.0870597674699799 275 1762 False False 0 0 0 0 0 0 0 0.264696169088507 0.00631387057219898 1.70493355197566 0 0 0.000974130102511011 0.99900286675807 0.998381221815451 0.999429948179957 12 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Gly271del Rv1258c_p.Gly271del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1823 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1755 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv1258c p.Gly277Ala Rv1258c_p.Gly277Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1786 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1718 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv1258c p.Gly322Arg Rv1258c_p.Gly322Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv1258c p.Gly360Asp Rv1258c_p.Gly360Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1787 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1719 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Gly360Ser Rv1258c_p.Gly360Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Gly363Val Rv1258c_p.Gly363Val 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 45 4407 16777 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.997324931637142 0.996422167208985 0.99804813798441 0.0425531914893617 0.00519558317674383 0.145405245488214 NA NA NA 0 0 0.078705100406843 NA NA NA NA 1810 1830 False False 0.169195471850339 0.0198804185003422 0.648224781244469 0 0 0.000836699794980095 0.997324931637142 0.996422167208985 0.99804813798441 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 43 3784 16003 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.997320204412314 0.996392011747749 0.998059960498693 0.0444444444444444 0.00542848870025094 0.151492900243339 NA NA NA 0 0 0.0822111211541385 NA NA NA NA 1742 1762 False False 0 0 0 0 0 0 0 0.196703377747185 0.0230881248419458 0.755695019549759 0 0 0.000974387411009493 0.997320204412314 0.996392011747749 0.998059960498693 37 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Gly375Arg Rv1258c_p.Gly375Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.23555131695149 1 1273 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 10.2590571436125 1 554.5 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Gly391Arg Rv1258c_p.Gly391Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1775 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1707 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 7 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Gly42fs Rv1258c_p.Gly42fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1806 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1738 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 5 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Gly7Ser Rv1258c_p.Gly7Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.108672907328017 Inf 0.190903590157321 377.5 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv1258c p.Gly88fs Rv1258c_p.Gly88fs 2 frameshift (see "Genomic_coordinates" sheet) 1 34 0 34 3 37 4406 16785 0.000680426400544341 0.000140342268876931 0.00198719451371054 0.997800499346094 0.996969539922644 0.998450890266575 0.075 0.0157421798510415 0.203864748732898 0 0 0.102817924259012 0 0 0.0948905874149899 0 0 0.436839555349089 0.000507322674353292 157 1830 True False 0.308884690409883 0.0609099925706486 0.976244605622236 0 0 0.000836889615584862 0.997800499346094 0.996969539922644 0.998450890266575 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 34 0 34 3 37 3783 16009 0.000792393026941363 0.000163440311798119 0.00231394549068866 0.997694129378038 0.996823047948966 0.998375950575295 0.075 0.0157421798510415 0.203864748732898 0 0 0.102817924259012 0 0 0.0948905874149899 0 0 0.485270602285468 0.00147077158042264 169 1762 True False 0 0 0 0 0 0 0 0.343121075079837 0.0676458013339254 1.08458225517914 0 0 0.000974644855475749 0.997694129378038 0.996823047948966 0.998375950575295 44 3) Uncertain significance DOWN from NotAwR to Uncertain yes 2 +Pyrazinamide Rv1258c p.Gly95Arg Rv1258c_p.Gly95Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv1258c p.Gly97Asp Rv1258c_p.Gly97Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Gly98del Rv1258c_p.Gly98del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1770 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1702 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.His254Arg Rv1258c_p.His254Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Ile12Val Rv1258c_p.Ile12Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1829 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1761 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv1258c p.Ile188fs Rv1258c_p.Ile188fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv1258c p.Ile314Thr Rv1258c_p.Ile314Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1784 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1716 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 1 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Leu106Pro Rv1258c_p.Leu106Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv1258c p.Leu109Phe Rv1258c_p.Leu109Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1811 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1743 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Leu193_Glu194insValGlnLeu Rv1258c_p.Leu193_Glu194insValGlnLeu 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1777 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1709 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv1258c p.Leu240Arg Rv1258c_p.Leu240Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 30 0 30 0 31 4409 16791 0 0 0.000836320411980403 0.998157175127808 0.997385268251665 0.998747557085331 0 0 0.11218874692237 0 0 0.115703308222027 0 0 0.11218874692237 0 0 0.498537933112898 0.0012752040805593 160 1830 True False 0 0 0.481503638343895 0 0 0.000836320411980403 0.998157175127808 0.997385268251665 0.998747557085331 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 30 0 30 0 31 3786 16015 0 0 0.000973872929872615 0.998068054343761 0.997258868578429 0.998686970855222 0 0 0.11218874692237 0 0 0.115703308222027 0 0 0.11218874692237 0 0 0.553809480029849 0.00372782256027205 172 1762 True False 0 0 0 0 0 0 0 0 0 0.534840942774559 0 0 0.000973872929872615 0.998068054343761 0.997258868578429 0.998686970855222 7 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Leu240Pro Rv1258c_p.Leu240Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Leu296Val Rv1258c_p.Leu296Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Leu355Pro Rv1258c_p.Leu355Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv1258c p.Leu35fs Rv1258c_p.Leu35fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1795 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1727 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv1258c p.Leu35Ser Rv1258c_p.Leu35Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1766 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1698 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv1258c p.Leu365Ser Rv1258c_p.Leu365Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1812 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1744 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv1258c p.Leu370Pro Rv1258c_p.Leu370Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Leu376fs Rv1258c_p.Leu376fs 2 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 4 4408 16818 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999762216145523 0.999391291831884 0.999935208223951 0.2 0.00505076337946806 0.716417936118089 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1788 1830 False False 0.95383393829401 0.0193637820130019 9.63941079069668 0 0 0.000836510060464794 0.999762216145523 0.999391291831884 0.999935208223951 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 4 3785 16042 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999750716689517 0.999361859844744 0.999932074644789 0.2 0.00505076337946806 0.716417936118089 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1720 1762 False False 0 0 0 0 0 0 0 1.05957727873183 0.0215096981131212 10.714411563858 0 0 0.000974130102511011 0.999750716689517 0.999361859844744 0.999932074644789 4 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Leu397Pro Rv1258c_p.Leu397Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1802 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1734 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Leu397Val Rv1258c_p.Leu397Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Lys249fs Rv1258c_p.Lys249fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 8 4409 16814 0 0 0.000836320411980403 0.999524432291047 0.999063158238902 0.999794661972981 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1794 1830 False False 0 0 2.2350715489366 0 0 0.000836320411980403 0.999524432291047 0.999063158238902 0.999794661972981 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 8 3786 16038 0 0 0.000973872929872615 0.999501433379035 0.999017862631239 0.999784730530787 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1726 1762 False False 0 0 0 0 0 0 0 0 0 2.48286669292342 0 0 0.000973872929872615 0.999501433379035 0.999017862631239 0.999784730530787 4 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Met121Ile Rv1258c_p.Met121Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1807 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1739 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Met121Val Rv1258c_p.Met121Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 2 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Met127Arg Rv1258c_p.Met127Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Met18Thr Rv1258c_p.Met18Thr 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1796 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1728 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Met230Thr Rv1258c_p.Met230Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Met242Ile Rv1258c_p.Met242Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1799 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1731 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 2 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Met242Thr Rv1258c_p.Met242Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Met291Arg Rv1258c_p.Met291Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Met315Ile Rv1258c_p.Met315Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Phe218Val Rv1258c_p.Phe218Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Phe251fs Rv1258c_p.Phe251fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1800 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1732 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Pro118Gln Rv1258c_p.Pro118Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1830 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1762 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv1258c p.Pro129Arg Rv1258c_p.Pro129Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 4409 16818 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.78028251232769 0.586765606596145 543.5 1830 False False 0 0 5.78028251232769 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 3786 16042 0 0 0.000973872929872615 0.999750716689517 0.999361859844744 0.999932074644789 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.42109836734015 1 554.5 1762 False False 0 0 0 0 0 0 0 0 0 6.42109836734015 0 0 0.000973872929872615 0.999750716689517 0.999361859844744 0.999932074644789 2 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Pro129His Rv1258c_p.Pro129His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv1258c p.Pro241Ser Rv1258c_p.Pro241Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Pro248Thr Rv1258c_p.Pro248Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Pro257Leu Rv1258c_p.Pro257Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 1 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Pro312Ser Rv1258c_p.Pro312Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 1 4408 16821 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0978242989491397 Inf 0.207677814413565 455 1830 False False 3.81601633393829 0.0486026416232846 298.829108180248 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 1 3785 16045 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.108666134732509 Inf 0.190913216680954 439 1762 False False 0 0 0 0 0 0 0 4.23910171730515 0.0539892730999128 331.863925136224 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv1258c p.Pro330Gln Rv1258c_p.Pro330Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Pro330Ser Rv1258c_p.Pro330Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Pro361Ser Rv1258c_p.Pro361Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 2 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Pro369Thr Rv1258c_p.Pro369Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 3 5 4406 16817 0.000680426400544341 0.000140342268876931 0.00198719451371054 0.999702770181904 0.999306502227134 0.999903483469113 0.375 0.0852334141372535 0.755136783633448 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.16674373617033 0.590711724501698 553 1830 False False 2.2901044030867 0.355484633702375 11.7779502227584 0 0 0.000836889615584862 0.999702770181904 0.999306502227134 0.999903483469113 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 3 5 3783 16041 0.000792393026941363 0.000163440311798119 0.00231394549068866 0.999688395861897 0.99927297097682 0.999898815491092 0.375 0.0852334141372535 0.755136783633448 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.6292357855337 0.590903217052071 517 1762 False False 0 0 0 0 0 0 0 2.5441712926249 0.394894449816007 13.0803425612061 0 0 0.000974644855475749 0.999688395861897 0.99927297097682 0.999898815491092 9 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Pro398Ala Rv1258c_p.Pro398Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.23555131695149 1 1273 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 10.2590571436125 1 554.5 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 3 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv1258c p.Pro414Ser Rv1258c_p.Pro414Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 14 113 4395 16709 0.00317532320254025 0.00173703251080297 0.00532191922970533 0.993282606111045 0.991929333188442 0.994460804785794 0.11023622047244 0.0615933164101758 0.178037754734659 NA NA NA 0 0 0.0321178557457393 NA NA NA NA NA NA False True 0.471021977911343 0.24928853956188 0.824521850100766 0 0 0.000838983340941379 0.993282606111045 0.991929333188442 0.994460804785794 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 14 113 3772 15933 0.00369783412572636 0.00202306972195899 0.00619656153938766 0.992957746478873 0.99153930682987 0.994192765853953 0.11023622047244 0.0615933164101758 0.178037754734659 NA NA NA 0 0 0.0321178557457393 NA NA NA NA NA NA False True 0 0 0 0 0 1 0 0.523329798515376 0.276914785491417 0.916230395446727 0 0 0.000977485749390535 0.992957746478873 0.99153930682987 0.994192765853953 110 Not assoc w R Previous WHO guidance 4) Not assoc w R - Interim DOWN from NotAwR to NotAwRI yes Prev. WHO 3 +Pyrazinamide Rv1258c p.Pro54Leu Rv1258c_p.Pro54Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 2 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Pro54Ser Rv1258c_p.Pro54Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Pro90His Rv1258c_p.Pro90His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1781 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1713 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Pro90Leu Rv1258c_p.Pro90Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Ser126* Rv1258c_p.Ser126* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1803 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1735 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Ser184Pro Rv1258c_p.Ser184Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1820 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1752 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 3 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Ser244Arg Rv1258c_p.Ser244Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1821 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1753 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv1258c p.Ser292Leu Rv1258c_p.Ser292Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1776 1830 False False Inf 1.57702975056642 Inf 0 0 0.000836889615584862 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1708 1762 False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf 0 0 0.000974644855475749 1 0.999770132403032 1 5 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv1258c p.Ser40Asn Rv1258c_p.Ser40Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 1 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Ser4Thr Rv1258c_p.Ser4Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 5 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Ter420Glyext*? Rv1258c_p.Ter420Glyext*? 2 stop_lost (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv1258c p.Thr167Ala Rv1258c_p.Thr167Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Thr167Met Rv1258c_p.Thr167Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Thr16Met Rv1258c_p.Thr16Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Thr173fs Rv1258c_p.Thr173fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Thr173Ile Rv1258c_p.Thr173Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Thr173Pro Rv1258c_p.Thr173Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 3 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Thr179fs Rv1258c_p.Thr179fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv1258c p.Thr234Ile Rv1258c_p.Thr234Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1825 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1757 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Thr290Ile Rv1258c_p.Thr290Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 3 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Thr297Ile Rv1258c_p.Thr297Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 7 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Thr371Ile Rv1258c_p.Thr371Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Thr379Lys Rv1258c_p.Thr379Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Thr390Ser Rv1258c_p.Thr390Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1793 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1725 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Thr59Arg Rv1258c_p.Thr59Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Thr64Ser Rv1258c_p.Thr64Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 5 4409 16817 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1804 1830 False False 0 0 4.16390782018879 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 3786 16041 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1736 1762 False False 0 0 0 0 0 0 0 0 0 4.62556638995023 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 2 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Trp220* Rv1258c_p.Trp220* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Trp94* Rv1258c_p.Trp94* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Tyr146Cys Rv1258c_p.Tyr146Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1771 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1703 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv1258c p.Tyr250Cys Rv1258c_p.Tyr250Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1778 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1710 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Tyr250His Rv1258c_p.Tyr250His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Tyr332fs Rv1258c_p.Tyr332fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv1258c p.Tyr334Cys Rv1258c_p.Tyr334Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1826 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1758 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv1258c p.Val156Asp Rv1258c_p.Val156Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv1258c p.Val209Ala Rv1258c_p.Val209Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Val219Ala Rv1258c_p.Val219Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 24 4409 16798 0 0 0.000836320411980403 0.998573296873142 0.997877917781838 0.999085677166006 0 0 0.142473597722525 NA NA NA 0 0 0.142473597722525 NA NA NA NA 1789 1830 False False 0 0 0.633335850709692 0 0 0.000836320411980403 0.998573296873142 0.997877917781838 0.999085677166006 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 24 3786 16022 0 0 0.000973872929872615 0.998504300137105 0.997775329312221 0.999041449122186 0 0 0.142473597722525 NA NA NA 0 0 0.142473597722525 NA NA NA NA 1721 1762 False False 0 0 0 0 0 0 0 0 0 0.70352464582317 0 0 0.000973872929872615 0.998504300137105 0.997775329312221 0.999041449122186 20 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Val224Ala Rv1258c_p.Val224Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.23555131695149 1 1273 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 10.2590571436125 1 554.5 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Val245Met Rv1258c_p.Val245Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1827 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1759 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 16 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Val280Leu Rv1258c_p.Val280Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 33 4408 16789 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99803828320057 0.99724611318723 0.998649271519963 0.0294117647058823 0.00074436423469026 0.153267669560317 NA NA NA 0 0 0.105762810074579 NA NA NA NA 1785 1830 False False 0.115416872903261 0.00284043394277482 0.689866613912622 0 0 0.000836510060464794 0.99803828320057 0.99724611318723 0.998649271519963 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 33 3785 16013 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.99794341268852 0.997112987994199 0.998583930071265 0.0294117647058823 0.00074436423469026 0.153267669560317 NA NA NA 0 0 0.105762810074579 NA NA NA NA 1717 1762 False False 0 0 0 0 0 0 0 0.128201433089147 0.00315445598555225 0.766349780827727 0 0 0.000974130102511011 0.99794341268852 0.997112987994199 0.998583930071265 54 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Val285Ile Rv1258c_p.Val285Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1813 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1745 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 3 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Val304Ala Rv1258c_p.Val304Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Val320Ala Rv1258c_p.Val320Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1767 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1699 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Val335Leu Rv1258c_p.Val335Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv1258c p.Val335Met Rv1258c_p.Val335Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.23555131695149 1 1273 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 10.2590571436125 1 554.5 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 1 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Val348Leu Rv1258c_p.Val348Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 4409 16817 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.16390782018879 0.590722354627394 560.5 1830 False False 0 0 4.16390782018879 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 3786 16041 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 4.62556638995023 0.590888399193514 509 1762 False False 0 0 0 0 0 0 0 0 0 4.62556638995023 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv1258c p.Val388Met Rv1258c_p.Val388Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 17 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv1258c p.Val66Ile Rv1258c_p.Val66Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 20.3214799903419 1 1273 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 22.56946568665 1 927 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 1 3) Uncertain significance No change no 1 +Pyrazinamide Rv1258c p.Val74Ala Rv1258c_p.Val74Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c c.1002G>A Rv3236c_c.1002G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.1011T>C Rv3236c_c.1011T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0978301145652783 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.1029G>A Rv3236c_c.1029G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.102G>A Rv3236c_c.102G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.1032C>G Rv3236c_c.1032C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.1032C>T Rv3236c_c.1032C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.1068G>A Rv3236c_c.1068G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 4409 16818 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.78028251232769 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 3786 16042 0 0 0.000973872929872615 0.999750716689517 0.999361859844744 0.999932074644789 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.42109836734015 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.108T>C Rv3236c_c.108T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0978301145652783 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.1105C>T Rv3236c_c.1105C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.1110C>G Rv3236c_c.1110C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.1119C>T Rv3236c_c.1119C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.111G>A Rv3236c_c.111G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.1143A>C Rv3236c_c.1143A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 7 43 4402 16779 0.00158766160127012 0.000638553061192671 0.00326843667440656 0.99744382356438 0.996558374595514 0.998149483637672 0.14 0.0581917003403721 0.267396002497008 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.620505478482296 0.235336883830534 1.39249115146853 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 7 41 3779 16005 0.00184891706286318 0.000743673531480306 0.00380574231364529 0.997444846067555 0.996535224928996 0.998165772517582 0.145833333333333 0.0607044693666369 0.277638340022028 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.723091022918697 0.273504717362428 1.62954118390026 NA NA NA NA NA NA 29 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.1149T>G Rv3236c_c.1149T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.121T>C Rv3236c_c.121T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0978301145652783 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.127T>C Rv3236c_c.127T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.-12delA Rv3236c_c.-12delA 2 upstream_gene_variant 3613127 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv3236c c.132C>T Rv3236c_c.132C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.159C>T Rv3236c_c.159C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.15G>A Rv3236c_c.15G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.-18T>C Rv3236c_c.-18T>C 2 upstream_gene_variant 3613134 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1741 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1673 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c c.1G>A Rv3236c_c.1G>A 2 initiator_codon_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.-23G>A Rv3236c_c.-23G>A 2 upstream_gene_variant 3613139 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c c.256C>T Rv3236c_c.256C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.716637886286628 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.270G>A Rv3236c_c.270G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.279G>C Rv3236c_c.279G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0978301145652783 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.-32G>A Rv3236c_c.-32G>A 2 upstream_gene_variant 3613148 1 1 0 1 1 1 4408 16821 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 148.49048666616 1 897.5 1830 False False 3.81601633393829 0.0486026416232846 298.829108180248 0 0 0.000836510060464794 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 3785 16045 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 164.911820358037 1 927 1762 False False 0 0 0 0 0 0 0 4.23910171730515 0.0539892730999128 331.863925136224 0 0 0.000974130102511011 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c c.-34G>C Rv3236c_c.-34G>C 2 upstream_gene_variant 3613150 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 3 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c c.354C>T Rv3236c_c.354C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.357C>T Rv3236c_c.357C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.-35C>T Rv3236c_c.-35C>T 2 upstream_gene_variant 3613151 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1720 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1652 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c c.387C>G Rv3236c_c.387C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.390G>T Rv3236c_c.390G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.408G>C Rv3236c_c.408G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.417C>T Rv3236c_c.417C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.423T>C Rv3236c_c.423T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 30 4408 16792 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.998216621091428 0.997455086506808 0.99879644827958 0.032258064516129 0.000816370071846613 0.167021116230227 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.126981246218995 0.00311557232559072 0.764318374666763 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 30 3785 16016 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.998130375171382 0.997332061268946 0.998738227457322 0.032258064516129 0.000816370071846613 0.167021116230227 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.141047996477322 0.00346009100591229 0.849070579190256 NA NA NA NA NA NA 32 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.438G>A Rv3236c_c.438G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0978301145652783 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.444G>A Rv3236c_c.444G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.-44C>T Rv3236c_c.-44C>T 2 upstream_gene_variant 3613160 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1700 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1632 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c c.468G>A Rv3236c_c.468G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.-489C>T Rv3236c_c.-489C>T 2 upstream_gene_variant 3613605 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1701 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1633 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c c.-490C>T Rv3236c_c.-490C>T 2 upstream_gene_variant 3613606 1 4 0 4 0 4 4409 16818 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.78028251232769 0.586765606596145 543.5 1830 False False 0 0 5.78028251232769 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 3786 16042 0 0 0.000973872929872615 0.999750716689517 0.999361859844744 0.999932074644789 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.42109836734015 1 554.5 1762 False False 0 0 0 0 0 0 0 0 0 6.42109836734015 0 0 0.000973872929872615 0.999750716689517 0.999361859844744 0.999932074644789 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c c.496T>C Rv3236c_c.496T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.504G>A Rv3236c_c.504G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.-509A>G Rv3236c_c.-509A>G 2 upstream_gene_variant 3613625 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c c.-512C>T Rv3236c_c.-512C>T 2 upstream_gene_variant 3613628 1 3 0 3 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.23555131695149 1 1273 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 10.2590571436125 1 554.5 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 2 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c c.-518C>A Rv3236c_c.-518C>A 2 upstream_gene_variant 3613634 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv3236c c.-520A>G Rv3236c_c.-520A>G 2 upstream_gene_variant 3613636 NA 0 0 0 34 441 4375 16381 0.00771149920616919 0.00534617862297411 0.0107595218761754 0.97378433004399 0.971256668536146 0.976146327017408 0.071578947368421 0.0500767343181403 0.0985905326090725 NA NA NA 0 0 0.00832991837243668 NA NA NA NA NA NA False True 0.288670683511499 0.197074162670685 0.410318267338875 0 0 0.00084281707665363 0.97378433004399 0.971256668536146 0.976146327017408 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 32 430 3754 15616 0.00845219228737453 0.00578827133991198 0.0119111956076972 0.973202044123146 0.970584744677398 0.97564584574393 0.0692640692640692 0.0478556886068709 0.0963758898026945 NA NA NA 0 0 0.00854209661575156 NA NA NA NA NA NA False True 1 1 1 0 0 1 0 0.309568708106701 0.208684597321277 0.444574294138912 0 0 0.000982170379158152 0.973202044123146 0.970584744677398 0.97564584574393 410 Not assoc w R 5) Not assoc w R No change yes 1 +Pyrazinamide Rv3236c c.522A>C Rv3236c_c.522A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.522A>G Rv3236c_c.522A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.-525C>T Rv3236c_c.-525C>T 2 upstream_gene_variant 3613641 NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1753 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1685 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv3236c c.-531G>T Rv3236c_c.-531G>T 2 upstream_gene_variant 3613647 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv3236c c.537C>G Rv3236c_c.537C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.537C>T Rv3236c_c.537C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.540G>A Rv3236c_c.540G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.546C>T Rv3236c_c.546C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 111 4409 16711 0 0 0.000836320411980403 0.993401498038283 0.992059062744361 0.994568770036258 0 0 0.0326869940239477 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 0 0.128150180538919 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 0 111 3786 15935 0 0 0.000973872929872615 0.993082388134114 0.991675303518626 0.994305957022232 0 0 0.0326869940239477 NA NA NA NA NA NA NA NA NA NA NA NA False True 1 1 1 0 0 0 0 0 0 0.142321072990333 NA NA NA NA NA NA 184 5) Not assoc w R Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.558G>A Rv3236c_c.558G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.576G>A Rv3236c_c.576G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.57G>T Rv3236c_c.57G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.585G>T Rv3236c_c.585G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.588C>T Rv3236c_c.588C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.594G>A Rv3236c_c.594G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.618C>A Rv3236c_c.618C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.61C>T Rv3236c_c.61C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.57702975056642 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.624G>A Rv3236c_c.624G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0978301145652783 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.63G>A Rv3236c_c.63G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.648A>G Rv3236c_c.648A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 9 4409 16813 0 0 0.000836320411980403 0.999464986327428 0.998984621445092 0.999755329427402 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.9328143827158 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 9 3786 16037 0 0 0.000973872929872615 0.999439112551414 0.998935529133907 0.999743495490327 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.14715011586227 NA NA NA NA NA NA 125 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.663G>A Rv3236c_c.663G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.690G>A Rv3236c_c.690G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.696G>A Rv3236c_c.696G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.699C>T Rv3236c_c.699C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.729T>G Rv3236c_c.729T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.747C>G Rv3236c_c.747C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.756C>T Rv3236c_c.756C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 11 4409 16811 0 0 0.000836320411980403 0.99934609440019 0.998830284178405 0.999673528922672 0 0 0.284914152918154 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.51991683293768 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 11 3786 16035 0 0 0.000973872929872615 0.999314470896173 0.998773730902855 0.999657738248111 0 0 0.284914152918154 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.68837982812114 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.771C>T Rv3236c_c.771C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.795G>C Rv3236c_c.795G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0978301145652783 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.798G>C Rv3236c_c.798G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0978301145652783 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.813C>T Rv3236c_c.813C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.816G>C Rv3236c_c.816G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.716637886286628 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.81A>T Rv3236c_c.81A>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.834C>T Rv3236c_c.834C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.837C>T Rv3236c_c.837C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0978301145652783 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.852G>T Rv3236c_c.852G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 4408 16821 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.81601633393829 0.0486026416232846 298.829108180248 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 3785 16045 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.23910171730515 0.0539892730999128 331.863925136224 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.867A>G Rv3236c_c.867A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.716637886286628 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.87G>A Rv3236c_c.87G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.883C>T Rv3236c_c.883C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.888C>T Rv3236c_c.888C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 142 56 4267 16766 0.0322068496257654 0.0271940387634329 0.0378511314579368 0.996671026037332 0.995679199869825 0.997484378678717 0.717171717171717 0.648970508080231 0.778742076818535 NA NA NA NA NA NA NA NA NA NA NA NA False False 9.96339013693126 7.2489158663798 13.8563142273695 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 141 56 3645 15990 0.037242472266244 0.0314384023238783 0.0437740911994377 0.996510033653246 0.995470350848612 0.997362672581567 0.715736040609137 0.647276086742287 0.777575471577073 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 11.0454144620811 8.03039368168309 15.3655885974501 NA NA NA NA NA NA 202 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.906A>G Rv3236c_c.906A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.716637886286628 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.909G>A Rv3236c_c.909G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.927G>A Rv3236c_c.927G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 4409 16818 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 5.78028251232769 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 3786 16042 0 0 0.000973872929872615 0.999750716689517 0.999361859844744 0.999932074644789 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 6.42109836734015 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.997C>A Rv3236c_c.997C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c c.999G>A Rv3236c_c.999G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 4408 16820 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999881108072762 0.999570588169705 0.999985601311719 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.9078947368421 0.0323314320919459 36.6634061310851 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 3785 16044 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999875358344758 0.999549824781286 0.999984904960856 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.11941875825627 0.0359146288488272 40.7195918479678 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide Rv3236c deletion Rv3236c_deletion 2 feature_ablation (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1724 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1656 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 17 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv3236c LoF Rv3236c_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 11 0 11 3 24 4406 16798 0.000680426400544341 0.000140342268876931 0.00198719451371054 0.998573296873142 0.997877917781838 0.999085677166006 0.111111111111111 0.0235274543808539 0.291586924273551 0 0 0.284914152918154 0 0 0.142473597722525 0 0 1.51977571130128 0.135361792282134 314 1830 False False 0.476566046300499 0.091819617110706 1.57038288845476 0 0 0.000836889615584862 0.998573296873142 0.997877917781838 0.999085677166006 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 0 11 3 24 3783 16022 0.000792393026941363 0.000163440311798119 0.00231394549068866 0.998504300137105 0.997775329312221 0.999041449122186 0.111111111111111 0.0235274543808539 0.291586924273551 0 0 0.284914152918154 0 0 0.142473597722525 0 0 1.68834956932917 0.139256255527819 293 1762 False False 0 0 0 0 0 0 0 0.529407877346021 0.101993926425141 1.74462954788432 0 0 0.000974644855475749 0.998504300137105 0.997775329312221 0.999041449122186 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv3236c p.Ala105Gly Rv3236c_p.Ala105Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Ala105Thr Rv3236c_p.Ala105Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 16 4409 16806 0 0 0.000836320411980403 0.999048864582094 0.998455873997109 0.999456249287664 0 0 0.205907214207822 NA NA NA 0 0 0.205907214207822 NA NA NA NA 1726 1830 False False 0 0 0.988876825211935 0 0 0.000836320411980403 0.999048864582094 0.998455873997109 0.999456249287664 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 14 3786 16032 0 0 0.000973872929872615 0.999127508413311 0.998536540247476 0.999522921242413 0 0 0.231635761650116 NA NA NA 0 0 0.231635761650116 NA NA NA NA 1658 1762 False False 0 0 0 0 0 0 0 0 0 1.27728416483145 0 0 0.000973872929872615 0.999127508413311 0.998536540247476 0.999522921242413 8 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Ala107Val Rv3236c_p.Ala107Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Ala117Pro Rv3236c_p.Ala117Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 5 6 4404 16816 0.00113404400090723 0.000368320285107068 0.00264447958048867 0.999643324218285 0.999223829869625 0.999869095386533 0.454545454545454 0.167488094063707 0.766206402340654 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.24398527951805 0.355986288738515 494 1830 False False 3.18195579775961 0.767790001252716 12.5239232138542 0 0 0.000837269515297261 0.999643324218285 0.999223829869625 0.999869095386533 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 5 6 3781 16040 0.00132065504490227 0.000428947757354115 0.0030792549559865 0.999626075034276 0.999186301793093 0.999862764161372 0.454545454545454 0.167488094063707 0.766206402340654 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.60458497194141 0.602709903156837 519 1762 False False 0 0 0 0 0 0 0 3.53521995944635 0.852924963668572 13.9120731491293 0 0 0.000975160152742905 0.999626075034276 0.999186301793093 0.999862764161372 60 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Ala122Val Rv3236c_p.Ala122Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 13 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Ala150Val Rv3236c_p.Ala150Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1738 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1670 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Ala161Thr Rv3236c_p.Ala161Thr 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 8 3 4401 16819 0.00181447040145157 0.000783674794110066 0.0035720830153558 0.999821662109142 0.999478910338162 0.999963220929399 0.727272727272727 0.390257440427578 0.939782265827093 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1717 1830 False False 10.1910171930621 2.44433582400046 59.6745756170083 0 0 0.000837840012003725 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 8 3 3778 16043 0.00211304807184363 0.00091269178353604 0.00415927925423806 0.999813037517138 0.999453714469566 0.999961442181588 0.727272727272727 0.390257440427578 0.939782265827093 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1649 1762 False False 0 0 0 0 0 0 0 11.3238044820892 2.71592126399482 66.4138737417137 0 0 0.000975934121100684 0.999813037517138 0.999453714469566 0.999961442181588 8 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Ala164Val Rv3236c_p.Ala164Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 1 4406 16821 0.000680426400544341 0.000140342268876931 0.00198719451371054 0.99994055403638 0.999668833292177 0.99999849495964 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 1708 1830 False False 11.4532455742169 0.919224933680734 599.12689591493 0 0 0.000836889615584862 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1640 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 5 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv3236c p.Ala16Val Rv3236c_p.Ala16Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Ala181Thr Rv3236c_p.Ala181Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv3236c p.Ala195Val Rv3236c_p.Ala195Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1742 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1674 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Ala238Val Rv3236c_p.Ala238Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1709 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1641 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 3 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Ala244Val Rv3236c_p.Ala244Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1719 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1651 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Ala256fs Rv3236c_p.Ala256fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1704 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1636 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Ala329Gly Rv3236c_p.Ala329Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1759 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1691 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Ala344Val Rv3236c_p.Ala344Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 5 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv3236c p.Ala357Val Rv3236c_p.Ala357Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 4409 16817 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 5.77993884793644 0.58676144625344 535 1830 False False 0 0 4.16390782018879 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 5 3786 16041 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 6.42069813886719 1 927 1762 False False 0 0 0 0 0 0 0 0 0 4.62556638995023 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 14 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Ala370Thr Rv3236c_p.Ala370Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 155 588 4254 16234 0.0351553640281242 0.0299155362599486 0.0410219726517651 0.965045773391986 0.962158984201168 0.967770289024556 0.208613728129205 0.179928985450399 0.239632531942673 NA NA NA 0 0 0.0062539665454113 NA NA NA NA NA NA False True 1.00596397468249 0.834580285673293 1.20679368792922 0 0 0.000866779619250756 0.965045773391986 0.962158984201168 0.967770289024556 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 95 516 3691 15530 0.0250924458531431 0.0203476097805553 0.0305882399462761 0.967842452947775 0.964995418413333 0.970518187720962 0.155482815057283 0.127653863854477 0.18668895463217 NA NA NA 0 0 0.0071234979391419 NA NA NA NA NA NA False True 0 1 1 0 0 1 0 0.774642488853045 0.613885881119424 0.968904382713066 0 0 0.00099892622270503 0.967842452947775 0.964995418413333 0.970518187720962 856 Not assoc w R 5) Not assoc w R No change yes 1 +Pyrazinamide Rv3236c p.Ala383Thr Rv3236c_p.Ala383Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1705 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1637 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Ala383Val Rv3236c_p.Ala383Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1755 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1687 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Ala39Ser Rv3236c_p.Ala39Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.23555131695149 1 1273 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 10.2590571436125 1 554.5 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Ala52Ser Rv3236c_p.Ala52Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Arg135Trp Rv3236c_p.Arg135Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 148.448081147381 1 1273 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 164.858125974995 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Arg141Gly Rv3236c_p.Arg141Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Arg141His Rv3236c_p.Arg141His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1729 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1661 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Arg142Gln Rv3236c_p.Arg142Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1750 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1682 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Arg146Trp Rv3236c_p.Arg146Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Arg201Cys Rv3236c_p.Arg201Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1752 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1684 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Arg201His Rv3236c_p.Arg201His 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 0 10 4409 16812 0 0 0.000836320411980403 0.999405540363809 0.998907040193061 0.999714897863756 0 0 0.30849710781876 0 0 0.369416647552819 0 0 0.30849710781876 0 0 2.23480572765696 0.218817691246652 458.5 1830 False False 0 0 1.70188592764298 0 0 0.000836320411980403 0.999405540363809 0.998907040193061 0.999714897863756 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 0 9 3786 16037 0 0 0.000973872929872615 0.999439112551414 0.998935529133907 0.999743495490327 0 0 0.336267116879942 0 0 0.369416647552819 0 0 0.336267116879942 0 0 2.4827119074894 0.366966494570421 481 1762 False False 0 0 0 0 0 0 0 0 0 2.14715011586227 0 0 0.000973872929872615 0.999439112551414 0.998935529133907 0.999743495490327 5 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Arg258Gln Rv3236c_p.Arg258Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Arg27* Rv3236c_p.Arg27* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1733 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1665 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Arg314Gln Rv3236c_p.Arg314Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1710 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1642 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Arg314Gly Rv3236c_p.Arg314Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Arg315Gln Rv3236c_p.Arg315Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 148.448081147381 1 1273 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 164.858125974995 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Arg321Cys Rv3236c_p.Arg321Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 148.439276452294 1 1273 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 164.847877704944 1 927 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Arg325His Rv3236c_p.Arg325His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 8 4409 16814 0 0 0.000836320411980403 0.999524432291047 0.999063158238902 0.999794661972981 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1764 1830 False False 0 0 2.2350715489366 0 0 0.000836320411980403 0.999524432291047 0.999063158238902 0.999794661972981 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 8 3786 16038 0 0 0.000973872929872615 0.999501433379035 0.999017862631239 0.999784730530787 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1696 1762 False False 0 0 0 0 0 0 0 0 0 2.48286669292342 0 0 0.000973872929872615 0.999501433379035 0.999017862631239 0.999784730530787 13 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Arg333Trp Rv3236c_p.Arg333Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1751 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1683 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 2 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Arg87Gly Rv3236c_p.Arg87Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Asn45His Rv3236c_p.Asn45His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 148.448081147381 1 1273 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 164.858125974995 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 2 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Asp114Glu Rv3236c_p.Asp114Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Asp257Gly Rv3236c_p.Asp257Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1765 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1697 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 2 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Asp283Gly Rv3236c_p.Asp283Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Gln217fs Rv3236c_p.Gln217fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Glu234Gly Rv3236c_p.Glu234Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv3236c p.Glu335fs Rv3236c_p.Glu335fs 2 frameshift (see "Genomic_coordinates" sheet) 1 6 0 6 0 11 4409 16811 0 0 0.000836320411980403 0.99934609440019 0.998830284178405 0.999673528922672 0 0 0.284914152918154 0 0 0.4592581264399 0 0 0.284914152918154 0 0 3.23933719415348 0.355847819875922 485 1830 False False 0 0 1.51991683293768 0 0 0.000836320411980403 0.99934609440019 0.998830284178405 0.999673528922672 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 11 3786 16035 0 0 0.000973872929872615 0.999314470896173 0.998773730902855 0.999657738248111 0 0 0.284914152918154 0 0 0.4592581264399 0 0 0.284914152918154 0 0 3.59870099869826 0.60280402190819 527 1762 False False 0 0 0 0 0 0 0 0 0 1.68837982812114 0 0 0.000973872929872615 0.999314470896173 0.998773730902855 0.999657738248111 18 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv3236c p.Glu335Gly Rv3236c_p.Glu335Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Gly115Asp Rv3236c_p.Gly115Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 9 0 9 2 9 4407 16813 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.999464986327428 0.998984621445092 0.999755329427402 0.181818181818181 0.0228311982999596 0.517755852360172 0 0 0.336267116879942 0 0 0.336267116879942 0 0 1.93369185894462 0.219085434365389 464 1830 False False 0.847792653102387 0.0891068669426637 4.09836797956212 0 0 0.000836699794980095 0.999464986327428 0.998984621445092 0.999755329427402 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 2 9 3784 16037 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999439112551414 0.998935529133907 0.999743495490327 0.181818181818181 0.0228311982999596 0.517755852360172 0 0 0.336267116879942 0 0 0.336267116879942 0 0 2.14828595634791 0.222623869904269 450 1762 False False 0 0 0 0 0 0 0 0.941801738313366 0.0989816794216474 4.55283747206664 0 0 0.000974387411009493 0.999439112551414 0.998935529133907 0.999743495490327 7 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Gly123Arg Rv3236c_p.Gly123Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 4409 16818 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.78028251232769 0.586765606596145 543.5 1830 False False 0 0 5.78028251232769 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 3786 16042 0 0 0.000973872929872615 0.999750716689517 0.999361859844744 0.999932074644789 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.42109836734015 1 554.5 1762 False False 0 0 0 0 0 0 0 0 0 6.42109836734015 0 0 0.000973872929872615 0.999750716689517 0.999361859844744 0.999932074644789 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Gly243Ser Rv3236c_p.Gly243Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 0 8 4409 16814 0 0 0.000836320411980403 0.999524432291047 0.999063158238902 0.999794661972981 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 2.2350715489366 0.218829042398071 461.5 1830 False False 0 0 2.2350715489366 0 0 0.000836320411980403 0.999524432291047 0.999063158238902 0.999794661972981 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 0 8 3786 16038 0 0 0.000973872929872615 0.999501433379035 0.999017862631239 0.999784730530787 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 2.48286669292342 0.36696353836705 478 1762 False False 0 0 0 0 0 0 0 0 0 2.48286669292342 0 0 0.000973872929872615 0.999501433379035 0.999017862631239 0.999784730530787 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Gly253Arg Rv3236c_p.Gly253Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 4409 16818 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.78028251232769 0.586765606596145 543.5 1830 False False 0 0 5.78028251232769 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 3786 16042 0 0 0.000973872929872615 0.999750716689517 0.999361859844744 0.999932074644789 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.42109836734015 1 554.5 1762 False False 0 0 0 0 0 0 0 0 0 6.42109836734015 0 0 0.000973872929872615 0.999750716689517 0.999361859844744 0.999932074644789 2 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Gly309Trp Rv3236c_p.Gly309Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Gly327Ala Rv3236c_p.Gly327Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 4409 16818 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 5.78028251232769 0.586765606596145 543.5 1830 False False 0 0 5.78028251232769 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 3786 16042 0 0 0.000973872929872615 0.999750716689517 0.999361859844744 0.999932074644789 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 6.42109836734015 1 554.5 1762 False False 0 0 0 0 0 0 0 0 0 6.42109836734015 0 0 0.000973872929872615 0.999750716689517 0.999361859844744 0.999932074644789 8 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Gly334Glu Rv3236c_p.Gly334Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1706 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1638 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Gly350Glu Rv3236c_p.Gly350Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1745 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1677 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Gly375Ser Rv3236c_p.Gly375Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1725 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1657 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Gly376Val Rv3236c_p.Gly376Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Gly47Cys Rv3236c_p.Gly47Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Gly61Asp Rv3236c_p.Gly61Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1756 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1688 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 6 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Gly61Ser Rv3236c_p.Gly61Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1727 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1659 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Gly74Ala Rv3236c_p.Gly74Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 1 6 4408 16816 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999643324218285 0.999223829869625 0.999869095386533 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.24103762738456 0.355898403474894 492.5 1830 False False 0.635813672111312 0.0138232628839914 5.24325822004213 0 0 0.000836510060464794 0.999643324218285 0.999223829869625 0.999869095386533 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 10.2590571436125 1 554.5 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 5 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.His237Arg Rv3236c_p.His237Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Ile189Met Rv3236c_p.Ile189Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0978301145652783 Inf 0.207668032593848 395.5 1830 False False Inf 0.0978301145652783 Inf 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv3236c p.Ile225Val Rv3236c_p.Ile225Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Ile340Val Rv3236c_p.Ile340Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 9 0 9 0 10 4409 16812 0 0 0.000836320411980403 0.999405540363809 0.998907040193061 0.999714897863756 0 0 0.30849710781876 0 0 0.336267116879942 0 0 0.30849710781876 0 0 1.93269943246534 0.219086360959574 471.5 1830 False False 0 0 1.70188592764298 0 0 0.000836320411980403 0.999405540363809 0.998907040193061 0.999714897863756 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 0 10 3786 16036 0 0 0.000973872929872615 0.999376791723794 0.998854197426924 0.999701108243012 0 0 0.30849710781876 0 0 0.336267116879942 0 0 0.30849710781876 0 0 2.14701618016533 0.222583920922824 443.5 1762 False False 0 0 0 0 0 0 0 0 0 1.89058845367291 0 0 0.000973872929872615 0.999376791723794 0.998854197426924 0.999701108243012 12 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Ile341Val Rv3236c_p.Ile341Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1740 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1672 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Ile58Met Rv3236c_p.Ile58Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 5 3 4404 16819 0.00113404400090723 0.000368320285107068 0.00264447958048867 0.999821662109142 0.999478910338162 0.999963220929399 0.625 0.244863216366551 0.914766585862746 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1743 1830 False False 6.36504692703602 1.23768373585682 41.0231847707768 0 0 0.000837269515297261 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 5 3 3781 16043 0.00132065504490227 0.000428947757354115 0.0030792549559865 0.999813037517138 0.999453714469566 0.999961442181588 0.625 0.244863216366551 0.914766585862746 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1675 1762 False False 0 0 0 0 0 0 0 7.07176232037379 1.37501841621148 45.5380701298121 0 0 0.000975160152742905 0.999813037517138 0.999453714469566 0.999961442181588 1 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Ile64Met Rv3236c_p.Ile64Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Leu110His Rv3236c_p.Leu110His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1735 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1667 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv3236c p.Leu110Phe Rv3236c_p.Leu110Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 4 4408 16818 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999762216145523 0.999391291831884 0.999935208223951 0.2 0.00505076337946806 0.716417936118089 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1721 1830 False False 0.95383393829401 0.0193637820130019 9.63941079069668 0 0 0.000836510060464794 0.999762216145523 0.999391291831884 0.999935208223951 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 4 3785 16042 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999750716689517 0.999361859844744 0.999932074644789 0.2 0.00505076337946806 0.716417936118089 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1653 1762 False False 0 0 0 0 0 0 0 1.05957727873183 0.0215096981131212 10.714411563858 0 0 0.000974130102511011 0.999750716689517 0.999361859844744 0.999932074644789 9 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Leu140Arg Rv3236c_p.Leu140Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 6 4409 16816 0 0 0.000836320411980403 0.999643324218285 0.999223829869625 0.999869095386533 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1737 1830 False False 0 0 3.24030155506377 0 0 0.000836320411980403 0.999643324218285 0.999223829869625 0.999869095386533 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 3786 16040 0 0 0.000973872929872615 0.999626075034276 0.999186301793093 0.999862764161372 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1669 1762 False False 0 0 0 0 0 0 0 0 0 3.59982301180526 0 0 0.000973872929872615 0.999626075034276 0.999186301793093 0.999862764161372 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Leu172Arg Rv3236c_p.Leu172Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1746 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1678 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Leu18Phe Rv3236c_p.Leu18Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Leu236fs Rv3236c_p.Leu236fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1707 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1639 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Leu249Phe Rv3236c_p.Leu249Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Leu263fs Rv3236c_p.Leu263fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1711 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1643 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv3236c p.Leu266Gln Rv3236c_p.Leu266Gln 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1732 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1664 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv3236c p.Leu287Arg Rv3236c_p.Leu287Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1722 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1654 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv3236c p.Leu369Val Rv3236c_p.Leu369Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 12 0 12 0 14 4409 16808 0 0 0.000836320411980403 0.999167756509333 0.998604030697473 0.99954493241661 0 0 0.231635761650116 0 0 0.264648469397051 0 0 0.231635761650116 0 0 1.37264377271648 0.144306079628658 322 1830 False False 0 0 1.14979365621044 0 0 0.000836320411980403 0.999167756509333 0.998604030697473 0.99954493241661 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 12 0 12 0 14 3786 16032 0 0 0.000973872929872615 0.999127508413311 0.998536540247476 0.999522921242413 0 0 0.231635761650116 0 0 0.264648469397051 0 0 0.231635761650116 0 0 1.52482570963011 0.139670611758682 301 1762 False False 0 0 0 0 0 0 0 0 0 1.27728416483145 0 0 0.000973872929872615 0.999127508413311 0.998536540247476 0.999522921242413 7 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Leu38Ser Rv3236c_p.Leu38Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 5 0 4404 16822 0.00113404400090723 0.000368320285107068 0.00264447958048867 1 0.999780735048249 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 1748 1830 False False Inf 3.49836879238979 Inf 0 0 0.000837269515297261 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 5 0 3781 16046 0.00132065504490227 0.000428947757354115 0.0030792549559865 1 0.999770132403032 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 1680 1762 False False 0 0 0 0 0 0 0 Inf 3.88652681138742 Inf 0 0 0.000975160152742905 1 0.999770132403032 1 4 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv3236c p.Leu69Phe Rv3236c_p.Leu69Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 18 0 18 0 18 4409 16804 0 0 0.000836320411980403 0.998929972654856 0.998309420654136 0.99936571457723 0 0 0.185301968137852 0 0 0.185301968137852 0 0 0.185301968137852 0 0 0.867306718440374 0.0353711279560557 237 1830 False False 0 0 0.867306718440374 0 0 0.000836320411980403 0.998929972654856 0.998309420654136 0.99936571457723 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 18 0 18 0 18 3786 16028 0 0 0.000973872929872615 0.998878225102829 0.998227689237744 0.999335033867569 0 0 0.185301968137852 0 0 0.185301968137852 0 0 0.185301968137852 0 0 0.963452773874723 0.0343358236342717 220 1762 False False 0 0 0 0 0 0 0 0 0 0.963452773874723 0 0 0.000973872929872615 0.998878225102829 0.998227689237744 0.999335033867569 58 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Leu8Ser Rv3236c_p.Leu8Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 2 2 4407 16820 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.999881108072762 0.999570588169705 0.999985601311719 0.5 0.067585986488543 0.932414013511457 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3318853928205 1 1273 1830 False False 3.8166553210801 0.276553001924986 52.6392074577436 0 0 0.000836699794980095 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 3785 16044 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999875358344758 0.999549824781286 0.999984904960856 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5768265057825 1 927 1762 False False 0 0 0 0 0 0 0 2.11941875825627 0.0359146288488272 40.7195918479678 0 0 0.000974130102511011 0.999875358344758 0.999549824781286 0.999984904960856 8 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Leu8* Rv3236c_p.Leu8* 2 stop_gained (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.23555131695149 1 1273 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 10.2590571436125 1 554.5 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Lys305Arg Rv3236c_p.Lys305Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1715 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1647 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv3236c p.Met290Ile Rv3236c_p.Met290Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Met310Thr Rv3236c_p.Met310Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 4 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Phe274Leu Rv3236c_p.Phe274Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Phe28Leu Rv3236c_p.Phe28Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1754 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1686 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 9 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv3236c p.Phe311Ser Rv3236c_p.Phe311Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 3 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Phe336Leu Rv3236c_p.Phe336Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 5 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Phe360Leu Rv3236c_p.Phe360Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 14 4409 16808 0 0 0.000836320411980403 0.999167756509333 0.998604030697473 0.99954493241661 0 0 0.231635761650116 NA NA NA 0 0 0.231635761650116 NA NA NA NA 1736 1830 False False 0 0 1.14979365621044 0 0 0.000836320411980403 0.999167756509333 0.998604030697473 0.99954493241661 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 14 3786 16032 0 0 0.000973872929872615 0.999127508413311 0.998536540247476 0.999522921242413 0 0 0.231635761650116 NA NA NA 0 0 0.231635761650116 NA NA NA NA 1668 1762 False False 0 0 0 0 0 0 0 0 0 1.27728416483145 0 0 0.000973872929872615 0.999127508413311 0.998536540247476 0.999522921242413 35 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Pro103Leu Rv3236c_p.Pro103Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Pro213Leu Rv3236c_p.Pro213Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1728 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1660 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv3236c p.Pro284Gln Rv3236c_p.Pro284Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1739 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1671 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv3236c p.Pro349Leu Rv3236c_p.Pro349Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1760 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1692 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Pro34Gln Rv3236c_p.Pro34Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1702 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1634 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Pro378fs Rv3236c_p.Pro378fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1734 1830 False False Inf 0.716637886286628 Inf 0 0 0.000836699794980095 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1666 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0 0 0.000974387411009493 1 0.999770132403032 1 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv3236c p.Pro91Ala Rv3236c_p.Pro91Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Pro91Ser Rv3236c_p.Pro91Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 10 2 8 26 12 4383 16810 0.00589702880471762 0.00385564427656477 0.00862865525716627 0.999286648436571 0.998754250286254 0.999631348241016 0.684210526315789 0.513472945593978 0.824974661098873 0.2 0.0252107263268333 0.556095462307641 0.142857142857142 0.0177945154831915 0.428129160909698 0.958818161076888 0.0991525321401187 4.80691485496634 1 1273 1830 False False 8.30975739599969 4.04337296340688 18.0909880715508 0.000456100342075256 5.52406409594045e-05 0.00164661000543666 0.999286648436571 0.998754250286254 0.999631348241016 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 4 2 3782 16044 0.00105652403592181 0.000287939890647285 0.00270289202199999 0.999875358344758 0.999549824781286 0.999984904960856 0.666666666666666 0.222778095503512 0.956728131707258 0 0 0.975 0 0 0.841886116991581 0 0 165.032037152779 1 927 1762 False False 0 0 0 0 0 0 0 8.4843997884717 1.21526196730161 93.8406264671703 0 0 0.000974902436017582 0.999875358344758 0.999549824781286 0.999984904960856 40 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Ser130Thr Rv3236c_p.Ser130Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 3 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Ser235Leu Rv3236c_p.Ser235Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 5 4409 16817 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1757 1830 False False 0 0 4.16390782018879 0 0 0.000836320411980403 0.999702770181904 0.999306502227134 0.999903483469113 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 3786 16041 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1689 1762 False False 0 0 0 0 0 0 0 0 0 4.62556638995023 0 0 0.000973872929872615 0.999688395861897 0.99927297097682 0.999898815491092 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Ser281Pro Rv3236c_p.Ser281Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1712 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1644 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Ser84Arg Rv3236c_p.Ser84Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 148.448081147381 1 1273 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 164.858125974995 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Ser85Asn Rv3236c_p.Ser85Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1713 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1645 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Ter386Tyrext*? Rv3236c_p.Ter386Tyrext*? 2 stop_lost (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv3236c p.Thr102Ala Rv3236c_p.Thr102Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2062 3073 2347 13749 0.467679745974143 0.452864043100568 0.48253830022881 0.817322553798597 0.811399009550915 0.823136178027342 0.40155793573515 0.388111744373462 0.415116133441179 NA NA NA 0 0 0.00119969614194023 NA NA NA NA NA NA False True 3.93082874316223 3.65907954510898 4.22216505548792 0 0 0.00157050787736701 0.817322553798597 0.811399009550915 0.823136178027342 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 1976 2934 1810 13112 0.521922873745377 0.505867596378021 0.537944277394048 0.817150691761186 0.811081386291791 0.823104806185458 0.40244399185336 0.388686890045804 0.416317201341473 NA NA NA 0 0 0.00125649674027792 NA NA NA NA NA NA False True 0 0 0 0 0 1 0 4.87884697224764 4.52158613148455 5.26384315018241 0 0 0.00203597952322274 0.817150691761186 0.811081386291791 0.823104806185458 11364 Not assoc w R Previous WHO guidance 4) Not assoc w R - Interim DOWN from NotAwR to NotAwRI yes Prev. WHO 3 +Pyrazinamide Rv3236c p.Thr125Ala Rv3236c_p.Thr125Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Thr148Lys Rv3236c_p.Thr148Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv3236c p.Thr174Pro Rv3236c_p.Thr174Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Thr186Ala Rv3236c_p.Thr186Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 4406 16822 0.000680426400544341 0.000140342268876931 0.00198719451371054 1 0.999780735048249 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1730 1830 False False Inf 1.57702975056642 Inf 0 0 0.000836889615584862 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 3783 16046 0.000792393026941363 0.000163440311798119 0.00231394549068866 1 0.999770132403032 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1662 1762 False False 0 0 0 0 0 0 0 Inf 1.75196919627044 Inf 0 0 0.000974644855475749 1 0.999770132403032 1 5 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv3236c p.Thr186Met Rv3236c_p.Thr186Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1761 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1693 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv3236c p.Thr211Pro Rv3236c_p.Thr211Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Thr250Met Rv3236c_p.Thr250Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Thr252Ser Rv3236c_p.Thr252Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 6 4409 16816 0 0 0.000836320411980403 0.999643324218285 0.999223829869625 0.999869095386533 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1762 1830 False False 0 0 3.24030155506377 0 0 0.000836320411980403 0.999643324218285 0.999223829869625 0.999869095386533 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 3786 16040 0 0 0.000973872929872615 0.999626075034276 0.999186301793093 0.999862764161372 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1694 1762 False False 0 0 0 0 0 0 0 0 0 3.59982301180526 0 0 0.000973872929872615 0.999626075034276 0.999186301793093 0.999862764161372 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Thr301Ala Rv3236c_p.Thr301Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1703 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1635 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 4 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv3236c p.Thr328Ser Rv3236c_p.Thr328Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1731 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1663 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 2 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Thr373Asn Rv3236c_p.Thr373Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1714 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1646 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv3236c p.Thr60Ala Rv3236c_p.Thr60Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 4 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Tyr126His Rv3236c_p.Tyr126His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 2 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Val106Ala Rv3236c_p.Val106Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 17 4409 16805 0 0 0.000836320411980403 0.998989418618475 0.998382452772912 0.999411192380357 0 0 0.195064322969093 NA NA NA 0 0 0.195064322969093 NA NA NA NA 1718 1830 False False 0 0 0.92412091928757 0 0 0.000836320411980403 0.998989418618475 0.998382452772912 0.999411192380357 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 17 3786 16029 0 0 0.000973872929872615 0.99894054593045 0.998304251550396 0.999382711664247 0 0 0.195064322969093 NA NA NA 0 0 0.195064322969093 NA NA NA NA 1650 1762 False False 0 0 0 0 0 0 0 0 0 1.02659962523702 0 0 0.000973872929872615 0.99894054593045 0.998304251550396 0.999382711664247 3 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Val124fs Rv3236c_p.Val124fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 4409 16818 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1744 1830 False False 0 0 5.78028251232769 0 0 0.000836320411980403 0.999762216145523 0.999391291831884 0.999935208223951 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 3786 16042 0 0 0.000973872929872615 0.999750716689517 0.999361859844744 0.999932074644789 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1676 1762 False False 0 0 0 0 0 0 0 0 0 6.42109836734015 0 0 0.000973872929872615 0.999750716689517 0.999361859844744 0.999932074644789 1 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Val124Gly Rv3236c_p.Val124Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv3236c p.Val151Ala Rv3236c_p.Val151Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 99 459 4310 16363 0.0224540712179632 0.018286117204848 0.0272700257803953 0.972714302698846 0.970139447992439 0.975123917478764 0.177419354838709 0.146603656798696 0.211695873192254 NA NA NA 0 0 0.00800456588036169 NA NA NA NA NA NA False True 0.818857194850097 0.650500214950765 1.02244593206203 0 0 0.00085552233634258 0.972714302698846 0.970139447992439 0.975123917478764 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 87 425 3699 15621 0.0229793977812995 0.0184455117918336 0.0282686681103209 0.973513648261248 0.970910448825437 0.975943219736301 0.169921875 0.138398350444173 0.205312228798794 NA NA NA 0 0 0.00864215637312826 NA NA NA NA NA NA False True 0 1 1 0 0 1 0 0.864479748103621 0.676454654843097 1.09438051538967 0 0 0.000996766875403067 0.973513648261248 0.970910448825437 0.975943219736301 575 Not assoc w R 5) Not assoc w R No change yes 1 +Pyrazinamide Rv3236c p.Val151Met Rv3236c_p.Val151Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 6 4409 16816 0 0 0.000836320411980403 0.999643324218285 0.999223829869625 0.999869095386533 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1747 1830 False False 0 0 3.24030155506377 0 0 0.000836320411980403 0.999643324218285 0.999223829869625 0.999869095386533 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 3786 16040 0 0 0.000973872929872615 0.999626075034276 0.999186301793093 0.999862764161372 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1679 1762 False False 0 0 0 0 0 0 0 0 0 3.59982301180526 0 0 0.000973872929872615 0.999626075034276 0.999186301793093 0.999862764161372 6 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Val182Gly Rv3236c_p.Val182Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Val182Ile Rv3236c_p.Val182Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1758 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1690 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv3236c p.Val183Leu Rv3236c_p.Val183Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1716 1830 False False Inf 0.716637886286628 Inf 0 0 0.000836699794980095 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1648 1762 False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf 0 0 0.000974387411009493 1 0.999770132403032 1 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv3236c p.Val20Ala Rv3236c_p.Val20Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1763 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1695 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv3236c p.Val20Met Rv3236c_p.Val20Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv3236c p.Val222Ala Rv3236c_p.Val222Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Val229dup Rv3236c_p.Val229dup 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Val232Met Rv3236c_p.Val232Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv3236c p.Val262Met Rv3236c_p.Val262Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 10 0 10 0 10 4409 16812 0 0 0.000836320411980403 0.999405540363809 0.998907040193061 0.999714897863756 0 0 0.30849710781876 0 0 0.30849710781876 0 0 0.30849710781876 0 0 1.70188592764298 0.232177773145798 476.5 1830 False False 0 0 1.70188592764298 0 0 0.000836320411980403 0.999405540363809 0.998907040193061 0.999714897863756 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 0 10 3786 16036 0 0 0.000973872929872615 0.999376791723794 0.998854197426924 0.999701108243012 0 0 0.30849710781876 0 0 0.30849710781876 0 0 0.30849710781876 0 0 1.89058845367291 0.225511848474235 452.5 1762 False False 0 0 0 0 0 0 0 0 0 1.89058845367291 0 0 0.000973872929872615 0.999376791723794 0.998854197426924 0.999701108243012 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Val293Ala Rv3236c_p.Val293Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Val300Ile Rv3236c_p.Val300Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 18 2 16 39 18 4370 16804 0.00884554320707643 0.00629739229832351 0.0120724992806418 0.998929972654856 0.998309420654136 0.99936571457723 0.684210526315789 0.547570158211228 0.800949922261781 0.111111111111111 0.0137512156643644 0.347120438608672 0.1 0.0123485271702948 0.316982714019082 0.48066361556064 0.0535999659870612 2.04577298223291 0.557725924394715 530 1830 False False 8.33150266971777 4.64772416552059 15.4868562606349 0.000457456541628545 5.54049114496996e-05 0.00165150322128118 0.998929972654856 0.998309420654136 0.99936571457723 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 9 1 3777 16045 0.00237717908082408 0.00108755584228183 0.00450780893694816 0.999937679172379 0.999652820032955 0.999998422174497 0.9 0.554983882971804 0.997471421455538 0 0 0.975 0 0 0.975 0 0 165.260215352078 1 927 1762 False False 0 0 0 0 0 0 0 38.232724384432 5.29419450309442 1660.92197563144 0 0 0.000976192383641408 0.999937679172379 0.999652820032955 0.999998422174497 24 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Val359Gly Rv3236c_p.Val359Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1723 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1655 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide Rv3236c p.Val365Ile Rv3236c_p.Val365Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1749 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1681 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Val67Leu Rv3236c_p.Val67Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide Rv3236c p.Val98Ile Rv3236c_p.Val98Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance No change no 1 +Pyrazinamide sigE c.108T>C sigE_c.108T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide sigE c.117C>T sigE_c.117C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide sigE c.129G>A sigE_c.129G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide sigE c.12C>T sigE_c.12C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 12 4407 16810 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 0.999286648436571 0.998754250286254 0.999631348241016 0.142857142857142 0.0177945154831915 0.428129160909698 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.635731033961122 0.069080499493271 2.85729378651737 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 11 3784 16035 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 0.999314470896173 0.998773730902855 0.999657738248111 0.153846153846153 0.0192066719825284 0.454471055676557 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.77046896021526 0.0829503544789356 3.53257429546585 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide sigE c.135G>A sigE_c.135G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 4407 16822 0.000453617600362894 5.49399175882254e-05 0.00163765214079901 1 0.999780735048249 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.716637886286628 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 3784 16046 0.000528262017960908 6.39813848374298e-05 0.00190694779298469 1 0.999770132403032 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.796077158748321 Inf NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide sigE c.147T>C sigE_c.147T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide sigE c.15C>T sigE_c.15C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide sigE c.-16C>T sigE_c.-16C>T 2 upstream_gene_variant 1364397 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE c.-17A>G sigE_c.-17A>G 2 upstream_gene_variant 1364396 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1678 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1610 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE c.180G>A sigE_c.180G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.23555131695149 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.2590571436125 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide sigE c.-1C>T sigE_c.-1C>T 2 upstream_gene_variant 1364412 1 1 0 1 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 148.448081147381 1 1273 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 164.858125974995 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE c.225C>A sigE_c.225C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide sigE c.225C>T sigE_c.225C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide sigE c.276C>T sigE_c.276C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide sigE c.-28C>T sigE_c.-28C>T 2 upstream_gene_variant 1364385 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE c.294G>A sigE_c.294G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 867 1174 3542 15648 0.196643229757314 0.185001737182725 0.208687952422925 0.930210438711211 0.926255501093543 0.934015839326327 0.424791768740813 0.403222818893194 0.446577082306699 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.26258083816783 2.9627257798379 3.59126861103015 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 861 1169 2925 14877 0.227416798732171 0.214147300674364 0.241108344078322 0.927146952511529 0.923016566500665 0.93112168081142 0.424137931034482 0.40251561319654 0.445979684765526 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.74608935974205 3.39665503074761 4.12998262853093 NA NA NA NA NA NA 2059 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide sigE c.-29C>G sigE_c.-29C>G 2 upstream_gene_variant 1364384 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE c.-30C>A sigE_c.-30C>A 2 upstream_gene_variant 1364383 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE c.324T>C sigE_c.324T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide sigE c.327C>T sigE_c.327C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide sigE c.-32G>A sigE_c.-32G>A 2 upstream_gene_variant 1364381 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE c.-32G>T sigE_c.-32G>T 2 upstream_gene_variant 1364381 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE c.334C>T sigE_c.334C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide sigE c.354C>T sigE_c.354C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 5 29 4404 16793 0.00113404400090723 0.000368320285107068 0.00264447958048867 0.998276067055047 0.997525075697192 0.998845160492959 0.147058823529411 0.0495284552561774 0.310565730395125 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.657435246954179 0.198587506862767 1.71914432183961 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 5 29 3781 16017 0.00132065504490227 0.000428947757354115 0.0030792549559865 0.998192695999002 0.997405433184333 0.998789296399478 0.147058823529411 0.0495284552561774 0.310565730395125 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.73037601802114 0.220579530691768 1.91000601829497 NA NA NA NA NA NA 15 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide sigE c.-35T>C sigE_c.-35T>C 2 upstream_gene_variant 1364378 NA 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1682 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1614 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE c.-39_-38insA sigE_c.-39_-38insA 2 upstream_gene_variant 1364374 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1690 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1622 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE c.390C>T sigE_c.390C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 4409 16816 0 0 0.000836320411980403 0.999643324218285 0.999223829869625 0.999869095386533 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.24030155506377 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 6 3786 16040 0 0 0.000973872929872615 0.999626075034276 0.999186301793093 0.999862764161372 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.59982301180526 NA NA NA NA NA NA 18 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide sigE c.-3C>T sigE_c.-3C>T 2 upstream_gene_variant 1364410 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1695 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1627 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE c.406C>T sigE_c.406C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide sigE c.408A>C sigE_c.408A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide sigE c.-41C>A sigE_c.-41C>A 2 upstream_gene_variant 1364372 NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1677 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1609 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE c.-41C>T sigE_c.-41C>T 2 upstream_gene_variant 1364372 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE c.433C>T sigE_c.433C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide sigE c.435G>A sigE_c.435G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide sigE c.438C>T sigE_c.438C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide sigE c.45A>G sigE_c.45A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0978301145652783 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide sigE c.465G>C sigE_c.465G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide sigE c.477A>G sigE_c.477A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide sigE c.-48C>T sigE_c.-48C>T 2 upstream_gene_variant 1364365 NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1684 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1616 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE c.492C>T sigE_c.492C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 7 4409 16815 0 0 0.000836320411980403 0.999583878254666 0.99914281931165 0.999832681632407 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.64713852578052 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 7 3786 16039 0 0 0.000973872929872615 0.999563754206656 0.999101374817905 0.99982458915172 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.94057641353956 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide sigE c.501C>T sigE_c.501C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide sigE c.-51G>A sigE_c.-51G>A 2 upstream_gene_variant 1364362 1 1 0 1 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 148.448081147381 1 1273 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 164.858125974995 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 4 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE c.525G>A sigE_c.525G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide sigE c.528C>T sigE_c.528C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 4409 16816 0 0 0.000836320411980403 0.999643324218285 0.999223829869625 0.999869095386533 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.24030155506377 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 6 3786 16040 0 0 0.000973872929872615 0.999626075034276 0.999186301793093 0.999862764161372 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.59982301180526 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide sigE c.549A>C sigE_c.549A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 72 0 4337 16822 0.0163302336130641 0.0127987649712039 0.0205215688355242 1 0.999780735048249 1 1 0.950055916294145 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 73.8234393855575 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 72 0 3714 16046 0.0190174326465927 0.0149089675462409 0.0238900760189216 1 0.999770132403032 1 1 0.950055916294145 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 82.3036174499525 Inf NA NA NA NA NA NA 30 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide sigE c.552T>C sigE_c.552T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide sigE c.558G>T sigE_c.558G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide sigE c.564T>C sigE_c.564T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide sigE c.567C>T sigE_c.567C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide sigE c.576G>A sigE_c.576G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide sigE c.577C>T sigE_c.577C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide sigE c.588G>A sigE_c.588G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide sigE c.603G>A sigE_c.603G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide sigE c.660G>T sigE_c.660G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.23555131695149 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.2590571436125 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide sigE c.690C>T sigE_c.690C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide sigE c.693C>T sigE_c.693C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 20.3226850581891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 22.5708705061656 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide sigE c.706C>T sigE_c.706C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 4408 16820 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.999881108072762 0.999570588169705 0.999985601311719 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.9078947368421 0.0323314320919459 36.6634061310851 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 3785 16044 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999875358344758 0.999549824781286 0.999984904960856 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.11941875825627 0.0359146288488272 40.7195918479678 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide sigE c.717C>T sigE_c.717C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide sigE c.759C>T sigE_c.759C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide sigE c.87T>C sigE_c.87T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 148.45688584004 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 164.868374241756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Pyrazinamide sigE LoF sigE_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 148.448081147381 1 1273 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 164.858125974995 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE p.Ala200Thr sigE_p.Ala200Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE p.Ala70Thr sigE_p.Ala70Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE p.Ala74Val sigE_p.Ala74Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE p.Arg151Gln sigE_p.Arg151Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 4409 16819 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 9.23555131695149 1 1273 1830 False False 0 0 9.23555131695149 0 0 0.000836320411980403 0.999821662109142 0.999478910338162 0.999963220929399 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 3786 16043 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 10.2590571436125 1 554.5 1762 False False 0 0 0 0 0 0 0 0 0 10.2590571436125 0 0 0.000973872929872615 0.999813037517138 0.999453714469566 0.999961442181588 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE p.Arg153Leu sigE_p.Arg153Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1699 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1631 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE p.Arg155Trp sigE_p.Arg155Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE p.Arg55Cys sigE_p.Arg55Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE p.Arg8Trp sigE_p.Arg8Trp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 45 158 4364 16664 0.0102063960081651 0.00745408432279884 0.0136333681856932 0.990607537748186 0.98903217200835 0.992009581958291 0.22167487684729 0.166524371288228 0.285143614472839 NA NA NA 0 0 0.0230768979897195 NA NA NA NA 1697 1830 False True 1.08755177574864 0.761629526787126 1.52600769857524 0 0 0.000844940603240236 0.990607537748186 0.98903217200835 0.992009581958291 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 23 126 3763 15920 0.00607501320655044 0.00385481943701651 0.00910163900404459 0.992147575719805 0.990657695822438 0.993454626457088 0.154362416107382 0.100439764078481 0.2225626806135 NA NA NA 0 0 0.0288524068567209 NA NA NA NA 1629 1762 False True 0 1 1 0 0 0 0 0.772264614943328 0.471694611555145 1.21317552419264 0 0 0.000979822464885251 0.992147575719805 0.990657695822438 0.993454626457088 260 5) Not assoc w R New NotAwR yes 5 +Pyrazinamide sigE p.Asn142Ser sigE_p.Asn142Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1686 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1618 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE p.Asn36His sigE_p.Asn36His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE p.Asp20Tyr sigE_p.Asp20Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1687 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1619 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE p.Asp22fs sigE_p.Asp22fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1680 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1612 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE p.Asp22Glu sigE_p.Asp22Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1683 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1615 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE p.Asp238Ala sigE_p.Asp238Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1688 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1620 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE p.Asp34Asn sigE_p.Asp34Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1698 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1630 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 5 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE p.Asp85Glu sigE_p.Asp85Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE p.Gln125Arg sigE_p.Gln125Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 4409 16816 0 0 0.000836320411980403 0.999643324218285 0.999223829869625 0.999869095386533 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.24030155506377 0.355876504746108 489.5 1830 False False 0 0 3.24030155506377 0 0 0.000836320411980403 0.999643324218285 0.999223829869625 0.999869095386533 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 3786 16040 0 0 0.000973872929872615 0.999626075034276 0.999186301793093 0.999862764161372 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 3.59982301180526 0.602786000899522 522.5 1762 False False 0 0 0 0 0 0 0 0 0 3.59982301180526 0 0 0.000973872929872615 0.999626075034276 0.999186301793093 0.999862764161372 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE p.Gln67Pro sigE_p.Gln67Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE p.Glu133Ala sigE_p.Glu133Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1675 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1607 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE p.Glu133Gly sigE_p.Glu133Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE p.Glu2Asp sigE_p.Glu2Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1692 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1624 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE p.Glu61Gly sigE_p.Glu61Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE p.Glu86Val sigE_p.Glu86Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE p.Gly104Asp sigE_p.Gly104Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 4409 16820 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 20.3226850581891 1 897.5 1830 False False 0 0 20.3226850581891 0 0 0.000836320411980403 0.999881108072762 0.999570588169705 0.999985601311719 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 3786 16044 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 22.5708705061656 1 927 1762 False False 0 0 0 0 0 0 0 0 0 22.5708705061656 0 0 0.000973872929872615 0.999875358344758 0.999549824781286 0.999984904960856 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE p.Gly10Val sigE_p.Gly10Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1696 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1628 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE p.Gly215Ala sigE_p.Gly215Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1676 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1608 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 26 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE p.Gly219Asp sigE_p.Gly219Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1693 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1625 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE p.Gly21Val sigE_p.Gly21Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE p.His107Tyr sigE_p.His107Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 5 4 4404 16818 0.00113404400090723 0.000368320285107068 0.00264447958048867 0.999762216145523 0.999391291831884 0.999935208223951 0.555555555555555 0.212008506778868 0.863004337734833 0 0 0.707598226178713 0 0 0.602364635616474 0 0 9.24548633834195 1 1273 1830 False False 4.77350136239782 1.02687879748317 24.0629076057242 0 0 0.000837269515297261 0.999762216145523 0.999391291831884 0.999935208223951 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 4 4 3782 16042 0.00105652403592181 0.000287939890647285 0.00270289202199999 0.999750716689517 0.999361859844744 0.999932074644789 0.5 0.157012770487058 0.842987229512941 0 0 0.707598226178713 0 0 0.602364635616474 0 0 10.269265852982 1 927 1762 False False 0 0 0 0 0 0 0 4.24167107350608 0.789584284388791 22.7799634176894 0 0 0.000974902436017582 0.999750716689517 0.999361859844744 0.999932074644789 4 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE p.His246Tyr sigE_p.His246Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 15 0 15 0 15 4409 16807 0 0 0.000836320411980403 0.999108310545714 0.998529719637006 0.999500845014484 0 0 0.218019360910534 0 0 0.218019360910534 0 0 0.218019360910534 0 0 1.06332174004809 0.0524316689057834 287 1830 False False 0 0 1.06332174004809 0 0 0.000836320411980403 0.999108310545714 0.998529719637006 0.999500845014484 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 15 0 15 0 15 3786 16031 0 0 0.000973872929872615 0.999065187585691 0.998458637051574 0.999476701181019 0 0 0.218019360910534 0 0 0.218019360910534 0 0 0.218019360910534 0 0 1.18122215318362 0.0916128629754431 281 1762 False False 0 0 0 0 0 0 0 0 0 1.18122215318362 0 0 0.000973872929872615 0.999065187585691 0.998458637051574 0.999476701181019 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE p.His252Gln sigE_p.His252Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE p.Ile214Val sigE_p.Ile214Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE p.Ile229Val sigE_p.Ile229Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE p.Leu222Ile sigE_p.Leu222Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE p.Leu35Phe sigE_p.Leu35Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 4408 16821 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 0.99994055403638 0.999668833292177 0.99999849495964 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 148.49048666616 1 897.5 1830 False False 3.81601633393829 0.0486026416232846 298.829108180248 0 0 0.000836510060464794 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 3785 16045 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 0.999937679172379 0.999652820032955 0.999998422174497 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 164.911820358037 1 927 1762 False False 0 0 0 0 0 0 0 4.23910171730515 0.0539892730999128 331.863925136224 0 0 0.000974130102511011 0.999937679172379 0.999652820032955 0.999998422174497 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE p.Met1? sigE_p.Met1? 2 start_lost (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE p.Met81Thr sigE_p.Met81Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE p.Pro160Leu sigE_p.Pro160Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 4408 16822 0.000226808800181447 5.74228516515847e-06 0.00126304279008631 1 0.999780735048249 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1685 1830 False False Inf 0.0978301145652783 Inf 0 0 0.000836510060464794 1 0.999780735048249 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 3785 16046 0.000264131008980454 6.68719580867032e-06 0.00147075558362238 1 0.999770132403032 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1617 1762 False False 0 0 0 0 0 0 0 Inf 0.108672907328017 Inf 0 0 0.000974130102511011 1 0.999770132403032 1 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE p.Pro160Ser sigE_p.Pro160Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE p.Pro171Ala sigE_p.Pro171Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE p.Pro171Leu sigE_p.Pro171Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE p.Pro184Leu sigE_p.Pro184Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE p.Pro7Thr sigE_p.Pro7Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1691 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1623 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE p.Ser29Arg sigE_p.Ser29Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE p.Ser29Asn sigE_p.Ser29Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1679 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1611 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 10 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE p.Thr12Pro sigE_p.Thr12Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE p.Thr38Met sigE_p.Thr38Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1681 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1613 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE p.Thr42Ile sigE_p.Thr42Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE p.Thr69Ser sigE_p.Thr69Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1694 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1626 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE p.Thr80Ala sigE_p.Thr80Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1689 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1621 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 3 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE p.Val251Ile sigE_p.Val251Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 1 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE p.Val256Ile sigE_p.Val256Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 2 3) Uncertain significance New Uncertain no 0 +Pyrazinamide sigE p.Val71Leu sigE_p.Val71Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 4409 16821 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 0 0 0.975 0 0 0.975 0 0 0.975 0 0 148.45688584004 1 897.5 1830 False False 0 0 148.45688584004 0 0 0.000836320411980403 0.99994055403638 0.999668833292177 0.99999849495964 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 3786 16045 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 0 0 0.975 0 0 0.975 0 0 0.975 0 0 164.868374241756 1 927 1762 False False 0 0 0 0 0 0 0 0 0 164.868374241756 0 0 0.000973872929872615 0.999937679172379 0.999652820032955 0.999998422174497 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK c.1011G>A glpK_c.1011G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.341150751115529 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.102C>T glpK_c.102C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1035G>A glpK_c.1035G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1045C>T glpK_c.1045C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1050C>T glpK_c.1050C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 5 0 16805 30532 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 1 0.999879187193184 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.66460481015123 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 5 0 11497 23707 0.00043470700747696 0.000141162766530747 0.00101416710312943 1 0.999844409142079 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.88913119689894 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1062C>T glpK_c.1062C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1089G>A glpK_c.1089G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1102C>T glpK_c.1102C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 10 26 16800 30506 0.000594883997620464 0.000285305684944214 0.00109373983334496 0.999148434429451 0.998752506314373 0.99944365605196 0.277777777777777 0.142002447263402 0.451861145067839 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.698397435897435 0.300457770383269 1.49734924731691 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 18 11502 23689 0 0 0.000320664925697395 0.999240730585902 0.998800291409329 0.999549948712402 0 0 0.185301968137852 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.468558999031164 NA NA NA NA NA NA 12 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1104G>A glpK_c.1104G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1107C>T glpK_c.1107C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1113A>G glpK_c.1113A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1122G>A glpK_c.1122G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1134C>T glpK_c.1134C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 991 4134 15819 26398 0.0589530041641879 0.0554392120711763 0.0626203359899441 0.864601074282719 0.860712170776728 0.868420465172283 0.193365853658536 0.182632679138612 0.204449395341104 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.400032411894192 0.371869367632194 0.430047251881239 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 657 3384 10845 20323 0.0571205007824726 0.0529483848326694 0.0615184909707342 0.857257350149744 0.852739581782993 0.861687344242539 0.162583518930957 0.151330200211802 0.174326936402085 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 0 0.363825618237642 0.333077970967476 0.396963525721683 NA NA NA NA NA NA 661 5) Not assoc w R Now listed Silent mutation no 0 +Rifampicin glpK c.1137C>T glpK_c.1137C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1161C>T glpK_c.1161C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1164C>T glpK_c.1164C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1177C>T glpK_c.1177C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1179G>A glpK_c.1179G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.117G>C glpK_c.117G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 6 0 16804 30532 0.000356930398572278 0.000130998068917797 0.000776724091447791 1 0.999879187193184 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 2.13890645017026 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1200G>C glpK_c.1200G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1209C>T glpK_c.1209C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.75142405620251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.120C>T glpK_c.120C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.341150751115529 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1215C>T glpK_c.1215C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1233C>T glpK_c.1233C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.123C>A glpK_c.123C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 9 26 16801 30506 0.000535395597858417 0.000244845253515427 0.00101610321951737 0.999148434429451 0.998752506314373 0.99944365605196 0.257142857142857 0.124893971916761 0.432558849694038 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.62852028038624 0.259076538659382 1.38454348731476 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 5 15 11497 23692 0.00043470700747696 0.000141162766530747 0.00101416710312943 0.999367275488252 0.9989566315242 0.999645827023281 0.25 0.0865714691014345 0.491045871707957 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.686903829984633 0.195261706738317 1.98878315626087 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1245C>T glpK_c.1245C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1257C>G glpK_c.1257C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 7 16810 30525 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.26007067420399 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.24912710990902 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1257C>T glpK_c.1257C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1260G>A glpK_c.1260G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 3 16809 30529 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999901742434167 0.999712876815577 0.99997973646933 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.605409800305391 0.0115361654751757 7.54087213596152 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1267T>C glpK_c.1267T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1269G>A glpK_c.1269G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 26 16810 30506 0 0 0.000219421459229958 0.999148434429451 0.998752506314373 0.99944365605196 0 0 0.132274604497754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.276689956335831 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 22 11502 23685 0 0 0.000320664925697395 0.999072004049436 0.998595338091004 0.999418341378366 0 0 0.154372512815574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.375993398548359 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1278T>C glpK_c.1278T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1281C>T glpK_c.1281C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1293C>T glpK_c.1293C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1299C>T glpK_c.1299C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.129G>A glpK_c.129G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.-12C>G glpK_c.-12C>G 2 upstream_gene_variant 4139767 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK c.1302G>A glpK_c.1302G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1305T>C glpK_c.1305T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1317G>A glpK_c.1317G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.750576632084797 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1329G>A glpK_c.1329G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.6329128986197 0.189104318453829 214.057761575796 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1341G>T glpK_c.1341G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 23 16810 30509 0 0 0.000219421459229958 0.999246691995283 0.998869881214224 0.999522409302755 0 0 0.148185128915224 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.315774113235122 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 21 11502 23686 0 0 0.000320664925697395 0.999114185683553 0.998646255755329 0.99945158598871 0 0 0.161097615219079 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.395534415781732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1356C>A glpK_c.1356C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.135G>A glpK_c.135G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1372C>T glpK_c.1372C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1383C>T glpK_c.1383C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1395C>T glpK_c.1395C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.-13A>G glpK_c.-13A>G 2 upstream_gene_variant 4139768 NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4223 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK c.1401G>A glpK_c.1401G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.141G>A glpK_c.141G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1422G>A glpK_c.1422G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1428T>C glpK_c.1428T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1437C>G glpK_c.1437C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1446A>C glpK_c.1446A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 13 1 16797 30531 0.000773349196906603 0.000411838091387593 0.00132208760075144 0.999967247478055 0.999817528289014 0.999999170778282 0.928571428571428 0.661315510068178 0.998193219340874 NA NA NA NA NA NA NA NA NA NA NA NA False False 23.6293981068047 3.54819873645803 999.432079931171 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 13 1 11489 23706 0.00113023821944009 0.000601937155487611 0.00193196626494298 0.999957818365883 0.999765001636458 0.999998932054057 0.928571428571428 0.661315510068178 0.998193219340874 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 26.8237444512142 4.02740452697283 1133.71711274468 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1452C>T glpK_c.1452C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1464A>G glpK_c.1464A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1470G>A glpK_c.1470G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1488T>C glpK_c.1488T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 23 16810 30509 0 0 0.000219421459229958 0.999246691995283 0.998869881214224 0.999522409302755 0 0 0.148185128915224 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.315774113235122 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 23 11502 23684 0 0 0.000320664925697395 0.99902982241532 0.998544610722761 0.99938489435488 0 0 0.148185128915224 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.358297593611852 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1491C>G glpK_c.1491C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1497T>G glpK_c.1497T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1503C>T glpK_c.1503C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1506C>A glpK_c.1506C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1527G>A glpK_c.1527G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.1990579265185 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1530C>T glpK_c.1530C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.153C>T glpK_c.153C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1542T>A glpK_c.1542T>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1542T>C glpK_c.1542T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.75142405620251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1545C>T glpK_c.1545C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1551C>A glpK_c.1551C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1551C>G glpK_c.1551C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.1551C>T glpK_c.1551C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 7 8 16803 30524 0.000416418798334324 0.000167437820935922 0.000857792460925722 0.999737979824446 0.999483781433772 0.999886871715824 0.466666666666666 0.212666729519307 0.734138652722603 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.58950782598345 0.490607621809112 5.01715818132646 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 7 7 11495 23700 0.000608589810467744 0.000244718560881119 0.00125352303681455 0.999704728561184 0.999391723222185 0.999881277590374 0.5 0.230360541448062 0.769639458551937 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06176598521096 0.616950017145769 6.890951816192 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.159C>T glpK_c.159C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 8 16810 30524 0 0 0.000219421459229958 0.999737979824446 0.999483781433772 0.999886871715824 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.06393155676265 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 8 11502 23699 0 0 0.000320664925697395 0.999662546927068 0.999335191784523 0.999854300817065 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.20731769892417 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.189C>T glpK_c.189C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.-18C>T glpK_c.-18C>T 2 upstream_gene_variant 4139773 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK c.-19T>G glpK_c.-19T>G 2 upstream_gene_variant 4139774 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK c.201C>A glpK_c.201C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.-20A>G glpK_c.-20A>G 2 upstream_gene_variant 4139775 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK c.-21_-20insC glpK_c.-21_-20insC 2 upstream_gene_variant 4139775 NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4125 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3461 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK c.219G>A glpK_c.219G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.234C>G glpK_c.234C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.908144446427509 0.0153974005043644 17.4461131425891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.234C>T glpK_c.234C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.238C>T glpK_c.238C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.246G>A glpK_c.246G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 21 16807 30511 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999312197039172 0.998948811248646 0.999574190302931 0.125 0.0265593149862489 0.323611358188833 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.259339220902855 0.0495291547242612 0.868755955824005 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 18 11499 23689 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.999240730585902 0.998800291409329 0.999549948712402 0.142857142857142 0.0304889676215155 0.363423987016981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.343348696988143 0.0647702783653527 1.17648932319441 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.261G>T glpK_c.261G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.264G>A glpK_c.264G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.267G>A glpK_c.267G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.267G>T glpK_c.267G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.27A>G glpK_c.27A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 9 16806 30523 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999705227302502 0.999440503684993 0.999865202576615 0.307692307692307 0.0909203945720966 0.614261661750705 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.807198487312732 0.181628007649071 2.89271097894034 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 8 11499 23699 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.999662546927068 0.999335191784523 0.999854300817065 0.272727272727272 0.0602177341729066 0.609742559572421 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.772860683537698 0.132058090819728 3.22064246074135 NA NA NA NA NA NA 11 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.288G>A glpK_c.288G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.341150751115529 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.306G>A glpK_c.306G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.309C>T glpK_c.309C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.315A>G glpK_c.315A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.318G>A glpK_c.318G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.330C>T glpK_c.330C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.336T>C glpK_c.336T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.75142405620251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.12235036001139 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.33C>T glpK_c.33C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.-34C>T glpK_c.-34C>T 2 upstream_gene_variant 4139789 NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4104 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3446 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK c.354C>G glpK_c.354C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.354C>T glpK_c.354C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.360C>T glpK_c.360C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.363C>G glpK_c.363C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.75142405620251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.12235036001139 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.363C>T glpK_c.363C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.369G>T glpK_c.369G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.-37delC glpK_c.-37delC 2 upstream_gene_variant 4139791 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK c.-38C>T glpK_c.-38C>T 2 upstream_gene_variant 4139793 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4167 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3495 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK c.39C>G glpK_c.39C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.408C>G glpK_c.408C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.414G>A glpK_c.414G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.417G>A glpK_c.417G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 24 16808 30508 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999213939473339 0.99883062854842 0.999496293299407 0.0769230769230769 0.00945539100371274 0.251302916695373 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.151257337775662 0.0173488943903465 0.609381215131598 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 14 11502 23693 0 0 0.000320664925697395 0.999409457122369 0.999009367705732 0.999677108302285 0 0 0.231635761650116 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.621144612257265 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.-41G>A glpK_c.-41G>A 2 upstream_gene_variant 4139796 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK c.420C>T glpK_c.420C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.429G>A glpK_c.429G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.435T>A glpK_c.435T>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.75142405620251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.12235036001139 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.-43C>A glpK_c.-43C>A 2 upstream_gene_variant 4139798 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 80.2910622977969 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK c.-43C>T glpK_c.-43C>T 2 upstream_gene_variant 4139798 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK c.444T>G glpK_c.444T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.6329128986197 0.189104318453829 214.057761575796 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.450C>A glpK_c.450C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.-46C>T glpK_c.-46C>T 2 upstream_gene_variant 4139801 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK c.-47_-45delGCG glpK_c.-47_-45delGCG 2 upstream_gene_variant 4139799 1 2 0 2 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 9.66996583219897 0.541987658825864 457.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK c.-47G>A glpK_c.-47G>A 2 upstream_gene_variant 4139802 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK c.492G>T glpK_c.492G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.495C>G glpK_c.495C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.750576632084797 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.495C>T glpK_c.495C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 16810 30526 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.54251408011679 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 6 11502 23701 0 0 0.000320664925697395 0.9997469101953 0.999449212060655 0.99990711502044 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.75038628279554 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.510C>T glpK_c.510C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 137 344 16673 30188 0.00814991076740035 0.00684666803335187 0.00962736486796511 0.988733132451198 0.987485203204147 0.989886718884991 0.284823284823284 0.244879530491436 0.327435770787625 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.721078780760985 0.586623773365231 0.882336199607622 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 105 307 11397 23400 0.00912884715701617 0.00747239090753281 0.0110403882616388 0.987050238326232 0.985528723290725 0.988450542670885 0.254854368932038 0.213453395625803 0.299816650568406 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 0 0.702224912607723 0.556524237438798 0.880243461500964 NA NA NA NA NA NA 66 5) Not assoc w R Now listed Silent mutation no 0 +Rifampicin glpK c.525A>G glpK_c.525A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 4 16806 30528 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999868989912223 0.999664596427238 0.999964303043777 0.5 0.157012770487058 0.842987229512941 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81649410924669 0.338292932357021 9.7540407308173 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 3 11501 23704 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.99987345509765 0.999630227076139 0.999973902638554 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.687012723531287 0.0130900577164196 8.55773267307823 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.528G>A glpK_c.528G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.528G>T glpK_c.528G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.54C>T glpK_c.54C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.558C>G glpK_c.558C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.561G>T glpK_c.561G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.570G>A glpK_c.570G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.570G>C glpK_c.570G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.597C>T glpK_c.597C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.-5A>G glpK_c.-5A>G 2 upstream_gene_variant 4139760 1 15 3 12 14 13 16796 30519 0.000832837596668649 0.000455392489979272 0.00139696554892221 0.999574217214725 0.999272008529012 0.999773269742809 0.518518518518518 0.319496546133383 0.71332745186806 0.2 0.0433120051058366 0.480891133806853 0.1875 0.0404737339059459 0.456456546231611 0.454259942843534 0.0822505003909916 1.68358977771026 0.28414456011882 288 4649 False False 1.95681206147983 0.852863709634979 4.52261491115726 0.00017858205845586 3.68294279675761e-05 0.000521802978396842 0.999574217214725 0.999272008529012 0.999773269742809 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 3 4 9 4 11493 23703 0.000782472613458529 0.000357856744032263 0.00148485474620048 0.999831273463534 0.999568049920357 0.99995402584539 0.692307692307692 0.385738338249294 0.909079605427903 0.428571428571428 0.0989882784425078 0.815948432359917 0.428571428571428 0.0989882784425078 0.815948432359917 1.54678935003915 0.226536975004443 9.1447018052269 0.689775437733398 494 3890 False False 0 0 0 0 0 0 0 4.64036805011746 1.29471906120951 20.6187854117997 0.000260960334029227 5.38195281624569e-05 0.000762445558728535 0.999831273463534 0.999568049920357 0.99995402584539 2 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK c.609C>T glpK_c.609C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.60C>T glpK_c.60C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.624A>C glpK_c.624A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 13 8 16797 30524 0.000773349196906603 0.000411838091387593 0.00132208760075144 0.999737979824446 0.999483781433772 0.999886871715824 0.619047619047619 0.384354390378645 0.818928374459826 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.95299755908793 1.13421886694045 8.22028199199201 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 6 5 11496 23702 0.000521648408972352 0.000191459062774625 0.00113506056981396 0.999789091829417 0.999507879904061 0.999931515258336 0.545454545454545 0.233793597659345 0.832511905936292 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.4741127348643 0.628946063075147 10.2530574950399 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.63C>T glpK_c.63C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.645C>T glpK_c.645C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 3 16809 30529 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999901742434167 0.999712876815577 0.99997973646933 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.605409800305391 0.0115361654751757 7.54087213596152 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.649C>T glpK_c.649C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 7 0 16803 30532 0.000416418798334324 0.000167437820935922 0.000857792460925722 1 0.999879187193184 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 2.61832748907777 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 7 0 11495 23707 0.000608589810467744 0.000244718560881119 0.00125352303681455 1 0.999844409142079 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 2.97179240572548 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.658T>C glpK_c.658T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.6C>G glpK_c.6C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.702G>C glpK_c.702G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.708G>A glpK_c.708G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.708G>T glpK_c.708G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.717T>C glpK_c.717T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.717T>G glpK_c.717T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.726C>T glpK_c.726C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.908144446427509 0.0153974005043644 17.4461131425891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.741G>T glpK_c.741G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 7 33 16803 30499 0.000416418798334324 0.000167437820935922 0.000857792460925722 0.998919166775841 0.99848244004434 0.999255890978622 0.175 0.0733827293520852 0.327790133361585 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.385019630332967 0.143710698209878 0.885369426041159 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 7 31 11495 23676 0.000608589810467744 0.000244718560881119 0.00125352303681455 0.998692369342388 0.998144431704435 0.999111360865311 0.184210526315789 0.0774268518388488 0.343261994310921 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.46508860795016 0.172779315747752 1.07700950372299 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.747C>G glpK_c.747C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.759G>A glpK_c.759G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.759G>T glpK_c.759G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.75C>A glpK_c.75C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.75C>T glpK_c.75C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.762G>A glpK_c.762G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.765C>T glpK_c.765C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.908144446427509 0.0153974005043644 17.4461131425891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.777C>A glpK_c.777C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.777C>T glpK_c.777C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.789T>C glpK_c.789T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 2 16808 30530 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999934494956111 0.999763393503742 0.99999206693684 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.8163969538315 0.131636449523742 25.0652602654423 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 2 11500 23705 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999915636731767 0.999695284447545 0.999989783053538 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06130434782608 0.149383229063395 28.4413197127326 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.795C>T glpK_c.795C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.-7A>G glpK_c.-7A>G 2 upstream_gene_variant 4139762 NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4105 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3447 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK c.801C>T glpK_c.801C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.810C>T glpK_c.810C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.816G>A glpK_c.816G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.828G>A glpK_c.828G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.843T>C glpK_c.843T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.84C>T glpK_c.84C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.852C>T glpK_c.852C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.859C>T glpK_c.859C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.864G>A glpK_c.864G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.873C>T glpK_c.873C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.75142405620251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.12235036001139 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.87C>T glpK_c.87C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.9820231071276 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.24912710990902 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.891A>G glpK_c.891A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 4 16806 30528 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999868989912223 0.999664596427238 0.999964303043777 0.5 0.157012770487058 0.842987229512941 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81649410924669 0.338292932357021 9.7540407308173 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 4 1 11498 23706 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 0.999957818365883 0.999765001636458 0.999998932054057 0.8 0.28358206388191 0.994949236620532 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 8.24699947817011 0.815939832795188 405.284913246419 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.-8T>C glpK_c.-8T>C 2 upstream_gene_variant 4139763 NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4195 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK c.900C>T glpK_c.900C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 6 16808 30526 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999803484868334 0.999572318737888 0.999927879105266 0.25 0.0318540262499442 0.650855794412824 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.605386323972711 0.0597336972185117 3.38610801139962 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 3 11500 23704 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.99987345509765 0.999630227076139 0.999973902638554 0.4 0.0527449505263169 0.853367200365326 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.37414492753623 0.114734681491877 11.9942804069209 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.906G>A glpK_c.906G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.912C>T glpK_c.912C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.921C>T glpK_c.921C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.936C>T glpK_c.936C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.945C>T glpK_c.945C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.969C>T glpK_c.969C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.96C>T glpK_c.96C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 8 16809 30524 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999737979824446 0.999483781433772 0.999886871715824 0.111111111111111 0.00280913674659921 0.482496514917337 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.226991492652745 0.00511932236302294 1.69341645046941 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 4 11501 23703 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999831273463534 0.999568049920357 0.99995402584539 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.515237805408225 0.0104655802548345 5.20753049950472 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.978C>T glpK_c.978C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.99T>C glpK_c.99T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin glpK c.-9T>G glpK_c.-9T>G 2 upstream_gene_variant 4139764 NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4260 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3563 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK deletion glpK_deletion 2 feature_ablation (see "Genomic_coordinates" sheet) 1 1 0 1 1 6 16809 30526 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999803484868334 0.999572318737888 0.999927879105266 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.975 0 0 0.4592581264399 0 0 70.7511120407489 1 1627.5 4649 False False 0.302675154183274 0.00658396461982027 2.49513982006856 0 0 0.000219434511605659 0.999803484868334 0.999572318737888 0.999927879105266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 4 11501 23703 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999831273463534 0.999568049920357 0.99995402584539 0.2 0.00505076337946806 0.716417936118089 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3557 3890 False False 0 0 0 0 0 0 0 0.515237805408225 0.0104655802548345 5.20753049950472 0 0 0.000320692802708327 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK LoF glpK_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 166 5 161 353 229 16457 30303 0.0209994051160023 0.0188853442627962 0.0232813783969232 0.99249967247478 0.991467165382427 0.993436733976794 0.606529209621993 0.565522378880485 0.646449138911242 0.0301204819277108 0.00985093348277087 0.0688885796060463 0.0213675213675213 0.00697352271830594 0.049157476459349 0.0571845996549637 0.0183080507209997 0.136284205357215 4.1929515022351e-24 10 4649 True False 2.83840380103978 2.39386757336372 3.37046578273934 0.000303729801968169 9.86273594366775e-05 0.000708660488795106 0.99249967247478 0.991467165382427 0.993436733976794 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 106 3 103 187 158 11315 23549 0.0162580420796383 0.0140264422674612 0.0187390734593869 0.993335301809592 0.992215657633347 0.994331278087351 0.542028985507246 0.48783765952666 0.595492807040684 0.0283018867924528 0.00587499548869049 0.0804865192942161 0.0186335403726708 0.00385929261890382 0.0534873542597413 0.0606180471836937 0.0123014912320562 0.182231759616583 3.55206131581321e-14 13 3890 True False 0 0 0 0 0 0 0 2.46321562617115 1.97976917031014 3.06738003722514 0.000265064499028096 5.46660081676283e-05 0.000774433607008233 0.993335301809592 0.992215657633347 0.994331278087351 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ala111Glu glpK_p.Ala111Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ala11Val glpK_p.Ala11Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 7 16810 30525 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 0 0 0.409616397225003 0 0 0.521823750104981 0 0 0.409616397225003 0 0 1.98189325920797 0.168444418238817 233.5 4649 False False 0 0 1.26007067420399 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ala139Val glpK_p.Ala139Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ala164Thr glpK_p.Ala164Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 4087 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 0 0 0.000219447565534303 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 3433 3890 False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 0 0 0.000320720684566658 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ala171Val glpK_p.Ala171Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 16809 30529 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999901742434167 0.999712876815577 0.99997973646933 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.39581433818102 0.556927644280045 795 4649 False False 0.605409800305391 0.0115361654751757 7.54087213596152 0 0 0.000219434511605659 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 3 11501 23704 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.99987345509765 0.999630227076139 0.999973902638554 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98868218084989 0.555670981350655 466 3890 False False 0 0 0 0 0 0 0 0.687012723531287 0.0130900577164196 8.55773267307823 0 0 0.000320692802708327 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ala18Thr glpK_p.Ala18Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ala19Val glpK_p.Ala19Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ala200Ser glpK_p.Ala200Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ala232Thr glpK_p.Ala232Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ala235Val glpK_p.Ala235Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4088 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3434 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ala245Thr glpK_p.Ala245Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ala265fs glpK_p.Ala265fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ala277Gly glpK_p.Ala277Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4138 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3472 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ala313Thr glpK_p.Ala313Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 4246 4649 False False 0 0 1.9820231071276 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ala318Thr glpK_p.Ala318Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4209 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3520 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ala318Val glpK_p.Ala318Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.67117271135833 0.542004252564565 721 4649 False False 0.908144446427509 0.0153974005043644 17.4461131425891 0 0 0.000219434511605659 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.9727417274169 1 1214.5 3890 False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 0 0 0.000320692802708327 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ala324Thr glpK_p.Ala324Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4111 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3450 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ala364Val glpK_p.Ala364Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 1 9 16809 30523 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999705227302502 0.999440503684993 0.999865202576615 0.1 0.00252857854446178 0.445016117028195 0 0 0.521823750104981 0 0 0.336267116879942 0 0 1.98188132013222 0.168444020519803 231 4649 False False 0.201763605475902 0.00460699063398853 1.45637661246692 0 0 0.000219434511605659 0.999705227302502 0.999440503684993 0.999865202576615 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 4 11501 23703 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999831273463534 0.999568049920357 0.99995402584539 0.2 0.00505076337946806 0.716417936118089 0 0 0.975 0 0 0.602364635616474 0 0 80.2809146182867 1 1214.5 3890 False False 0 0 0 0 0 0 0 0.515237805408225 0.0104655802548345 5.20753049950472 0 0 0.000320692802708327 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ala370fs glpK_p.Ala370fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4144 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ala370Val glpK_p.Ala370Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4196 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3511 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ala377Val glpK_p.Ala377Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3535 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ala37Val glpK_p.Ala37Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4156 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3486 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ala380Val glpK_p.Ala380Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ala391Val glpK_p.Ala391Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ala394Thr glpK_p.Ala394Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ala396fs glpK_p.Ala396fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3473 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ala396Gly glpK_p.Ala396Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4132 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3466 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ala396Ser glpK_p.Ala396Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ala396Val glpK_p.Ala396Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4126 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3462 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ala400Val glpK_p.Ala400Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ala40Ser glpK_p.Ala40Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 70.7668929171829 1 1627.5 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 0 0 0.000219447565534303 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 80.2980353694986 1 1214.5 3890 False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 0 0 0.000320720684566658 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ala414Val glpK_p.Ala414Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ala440Gly glpK_p.Ala440Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4257 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ala453Thr glpK_p.Ala453Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ala453Val glpK_p.Ala453Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 2 16808 30530 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999934494956111 0.999763393503742 0.99999206693684 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4265 4649 False False 1.8163969538315 0.131636449523742 25.0652602654423 0 0 0.000219447565534303 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3568 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ala457Ser glpK_p.Ala457Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4150 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3482 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ala457Val glpK_p.Ala457Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ala463Glu glpK_p.Ala463Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ala463Val glpK_p.Ala463Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4210 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3521 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ala464Gly glpK_p.Ala464Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 4168 4649 False False 0 0 1.9820231071276 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 3496 3890 False False 0 0 0 0 0 0 0 0 0 2.24912710990902 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ala467Ser glpK_p.Ala467Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ala467Val glpK_p.Ala467Val 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4197 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3512 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ala472Glu glpK_p.Ala472Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4186 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3508 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ala472Pro glpK_p.Ala472Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4161 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3489 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ala479Thr glpK_p.Ala479Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ala498Gly glpK_p.Ala498Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4181 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ala498Val glpK_p.Ala498Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ala501Asp glpK_p.Ala501Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ala53Val glpK_p.Ala53Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ala77Val glpK_p.Ala77Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4236 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3542 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ala86Val glpK_p.Ala86Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4177 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3504 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ala87Val glpK_p.Ala87Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4112 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3451 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Arg102Trp glpK_p.Arg102Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Arg118His glpK_p.Arg118His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Arg121Cys glpK_p.Arg121Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4099 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Arg131Ser glpK_p.Arg131Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 9.66996583219897 0.541987658825864 457.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 10.9708654377183 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Arg136Ser glpK_p.Arg136Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4145 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3477 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Arg137Cys glpK_p.Arg137Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0465715996825058 Inf 0.355075831185839 416 4649 False False Inf 0.0465715996825058 Inf 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0528490600080728 Inf 0.32667783805277 340.5 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Arg225Trp glpK_p.Arg225Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Arg297Gln glpK_p.Arg297Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Arg334Cys glpK_p.Arg334Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4127 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3463 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Arg334Gly glpK_p.Arg334Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Arg351His glpK_p.Arg351His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Arg395Ser glpK_p.Arg395Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4203 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Arg406Cys glpK_p.Arg406Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4106 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3448 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Arg41Cys glpK_p.Arg41Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0465715996825058 Inf 0.355075831185839 416 4649 False False Inf 0.0465715996825058 Inf 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Arg478Gln glpK_p.Arg478Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 70.7538526941519 1 1627.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Arg509Trp glpK_p.Arg509Trp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4187 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Arg52Trp glpK_p.Arg52Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Arg66Ser glpK_p.Arg66Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4093 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3439 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Arg94Leu glpK_p.Arg94Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Asn110fs glpK_p.Asn110fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4151 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3483 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Asn183Ser glpK_p.Asn183Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4133 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3467 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Asn199fs glpK_p.Asn199fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4094 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3440 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Asn279fs glpK_p.Asn279fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4227 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3536 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Asn279Lys glpK_p.Asn279Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4214 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3524 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Asn285fs glpK_p.Asn285fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Asn299Asp glpK_p.Asn299Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 25 7 16785 30525 0.00148720999405116 0.000962667916776425 0.00219463783814356 0.99977073234639 0.999527678427408 0.999907817703152 0.78125 0.600271736287892 0.90722846771528 0 0 0.4592581264399 0 0 0.409616397225003 0 0 1.54476106121305 0.0958995314104847 213 4649 False False 6.49495723222264 2.72994727681148 17.7839945356193 0 0 0.000219748235144057 0.99977073234639 0.999527678427408 0.999907817703152 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 9 3 11493 23704 0.000782472613458529 0.000357856744032263 0.00148485474620048 0.99987345509765 0.999630227076139 0.999973902638554 0.75 0.42814153812181 0.945139355472007 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.99215604404244 0.555677234634748 487 3890 False False 0 0 0 0 0 0 0 6.18741842860871 1.54367622261538 35.5288257485558 0 0 0.000320915993408392 0.99987345509765 0.999630227076139 0.999973902638554 5 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Asn312Lys glpK_p.Asn312Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4215 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3525 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Asn356Ser glpK_p.Asn356Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4266 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3569 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Asn388Lys glpK_p.Asn388Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.67117271135833 0.542004252564565 721 4649 False False 0.908144446427509 0.0153974005043644 17.4461131425891 0 0 0.000219434511605659 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.9727417274169 1 1214.5 3890 False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 0 0 0.000320692802708327 0.999915636731767 0.999695284447545 0.999989783053538 2 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Asn390Ser glpK_p.Asn390Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Asn59Asp glpK_p.Asn59Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4089 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3435 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Asn59Lys glpK_p.Asn59Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Asn59Ser glpK_p.Asn59Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4139 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Asn76Lys glpK_p.Asn76Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Asn79fs glpK_p.Asn79fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4113 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3452 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Asn92Ser glpK_p.Asn92Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4114 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3453 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Asp120Ala glpK_p.Asp120Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3443 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Asp120Asn glpK_p.Asp120Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4178 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Asp129His glpK_p.Asp129His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4119 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3457 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Asp160Asn glpK_p.Asp160Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 2 5 16808 30527 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999836237390279 0.999617874429585 0.999946824656822 0.285714285714285 0.0366925661760855 0.709579136262657 0 0 0.841886116991581 0 0 0.521823750104981 0 0 9.6707983789131 0.541999104875973 708 4649 False False 0.726487386958591 0.069161301215026 4.43811993507661 0 0 0.000219447565534303 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 4 11500 23703 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999831273463534 0.999568049920357 0.99995402584539 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.975 0 0 0.602364635616474 0 0 80.2878868097956 1 1214.5 3890 False False 0 0 0 0 0 0 0 1.0305652173913 0.0931903474189042 7.19201282268065 0 0 0.000320720684566658 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Asp170Glu glpK_p.Asp170Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Asp170Gly glpK_p.Asp170Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Asp177Asn glpK_p.Asp177Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.67117271135833 0.542004252564565 721 4649 False False 0.908144446427509 0.0153974005043644 17.4461131425891 0 0 0.000219434511605659 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Asp177Glu glpK_p.Asp177Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Asp177Gly glpK_p.Asp177Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Asp214Gly glpK_p.Asp214Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Asp214Val glpK_p.Asp214Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4095 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Asp215Gly glpK_p.Asp215Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4216 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3526 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Asp3Asn glpK_p.Asp3Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Asp407Asn glpK_p.Asp407Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 4.39540875925228 0.556930310247326 910.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Asp407Glu glpK_p.Asp407Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4128 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Asp446Tyr glpK_p.Asp446Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.908144446427509 0.0153974005043644 17.4461131425891 1 1627.5 4649 False False 0.908144446427509 0.0153974005043644 17.4461131425891 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 2.06121206851578 0.0262561678399451 161.601678830082 0.54664351365823 365.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Asp484Asn glpK_p.Asp484Asn 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4169 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Asp492Gly glpK_p.Asp492Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3454 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Asp493fs glpK_p.Asp493fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4237 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3543 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Asp493Gly glpK_p.Asp493Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4217 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3527 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Asp494del glpK_p.Asp494del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Asp84Ala glpK_p.Asp84Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Asp84Glu glpK_p.Asp84Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 24 0 24 5 30 16805 30502 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 0.999017424341674 0.998597606821861 0.999336965202819 0.142857142857142 0.0480607784036389 0.302571351690951 0 0 0.142473597722525 0 0 0.115703308222027 0 0 0.301591824708695 4.2280558510677e-05 43 4649 True False 0.302509173856987 0.0916195946075888 0.787658452632322 0 0 0.000219486736640675 0.999017424341674 0.998597606821861 0.999336965202819 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 3 15 11499 23692 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.999367275488252 0.9989566315242 0.999645827023281 0.166666666666666 0.0357850831215746 0.414177491394774 0 0 0.30849710781876 0 0 0.218019360910534 0 0 0.919393420834676 0.0366163656975801 105 3890 False False 0 0 0 0 0 0 0 0.412070614836072 0.0764500134044006 1.45707959571218 0 0 0.000320748571273651 0.999367275488252 0.9989566315242 0.999645827023281 9 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Cys271Arg glpK_p.Cys271Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Cys271Gly glpK_p.Cys271Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Cys271Tyr glpK_p.Cys271Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4162 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3490 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Cys29Tyr glpK_p.Cys29Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 38 1 37 84 85 16726 30447 0.00499702558001189 0.00398772303390812 0.00618297477397907 0.997216035634744 0.996558718794529 0.997775681133764 0.497041420118343 0.419341293728722 0.574847122023948 0.0263157894736842 0.000666036204202366 0.13809902979242 0.0116279069767441 0.000294349786695055 0.0630905162785009 0.0491983673258335 0.0012174480923665 0.291758517093765 1.63104841542382e-06 36 4649 True False 1.79892383116106 1.31377514281554 2.46280307190751 5.97835834279906e-05 1.51358814036695e-06 0.000333047292390407 0.997216035634744 0.996558718794529 0.997775681133764 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 35 1 34 78 77 11424 23630 0.00678142931664058 0.00536402186961339 0.0084564047469906 0.996752014173029 0.995942222834204 0.997435916007205 0.503225806451612 0.421895924071895 0.584430018491688 0.0285714285714285 0.000723104376338095 0.149172079656431 0.0128205128205128 0.000324534609097223 0.0693727407856049 0.0608368347338935 0.001500864268353 0.362750205022884 3.20402841813585e-05 33 3890 True False 0 0 0 0 0 0 0 2.09531539888682 1.5082467460728 2.91131557781378 8.7527352297593e-05 2.21599824351601e-06 0.000487573635832083 0.996752014173029 0.995942222834204 0.997435916007205 9 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Cys307Arg glpK_p.Cys307Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Cys307Phe glpK_p.Cys307Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Cys402Tyr glpK_p.Cys402Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Gln115Arg glpK_p.Gln115Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Gln153Pro glpK_p.Gln153Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4115 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3455 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Gln153* glpK_p.Gln153* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4247 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3551 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Gln262Arg glpK_p.Gln262Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4170 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3497 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Gln331His glpK_p.Gln331His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Gln336His glpK_p.Gln336His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4100 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3444 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Gln345Lys glpK_p.Gln345Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Gln345Pro glpK_p.Gln345Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4120 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3458 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Gln352His glpK_p.Gln352His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Gln404Glu glpK_p.Gln404Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4204 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Gln404His glpK_p.Gln404His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4157 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3487 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Gln421His glpK_p.Gln421His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4228 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3537 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Gln439Lys glpK_p.Gln439Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Gln508* glpK_p.Gln508* 2 stop_gained (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Gln9Glu glpK_p.Gln9Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 4 16809 30528 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999868989912223 0.999664596427238 0.999964303043777 0.2 0.00505076337946806 0.716417936118089 0 0 0.841886116991581 0 0 0.602364635616474 0 0 9.67054020695107 0.541995555671939 489 4649 False False 0.454042477244333 0.00922341562850508 4.58878013974823 0 0 0.000219434511605659 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 80.2773259044493 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Glu157Gly glpK_p.Glu157Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 1 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Glu167Gly glpK_p.Glu167Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4121 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Glu209Lys glpK_p.Glu209Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 24 50 16786 30482 0.00142772159428911 0.000914975681329737 0.00212359656152999 0.99836237390279 0.997841557102341 0.998784285563698 0.324324324324324 0.220045777426374 0.443159701826802 NA NA NA 0 0 0.0711217364641976 NA NA NA NA 4198 4649 False True 0.871640652925056 0.51209490428866 1.44576579364302 0 0 0.000219735145421064 0.99836237390279 0.997841557102341 0.998784285563698 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 24 49 11478 23658 0.00208659363588941 0.001337363263423 0.00310310526233451 0.997933099928291 0.99726835820432 0.998470516759952 0.328767123287671 0.223256763070305 0.448659986437456 NA NA NA 0 0 0.0725192636642774 NA NA NA NA 3513 3890 False True 0 1 1 0 0 0 0 1.0095479906547 0.592142536247878 1.67833053938175 0 0 0.000321335314405605 0.997933099928291 0.99726835820432 0.998470516759952 4 5) Not assoc w R New NotAwR yes 5 +Rifampicin glpK p.Glu216Gln glpK_p.Glu216Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4188 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Glu216Gly glpK_p.Glu216Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4134 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3468 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Glu230Ala glpK_p.Glu230Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 2 12 16808 30520 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999606969736669 0.999313555980458 0.999796899563454 0.142857142857142 0.0177945154831915 0.428129160909698 0 0 0.602364635616474 0 0 0.264648469397051 0 0 2.75103038207675 0.30435310992687 297 4649 False False 0.302633666508012 0.032889580275051 1.35967332152622 0 0 0.000219447565534303 0.999606969736669 0.999313555980458 0.999796899563454 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 1 10 11501 23697 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999578183658835 0.999224402000993 0.999797704727851 0.0909090909090909 0.00229897221381426 0.412779916988382 0 0 0.602364635616474 0 0 0.30849710781876 0 0 3.12183139401901 0.310778870979808 229 3890 False False 0 0 0 0 0 0 0 0.206042952786714 0.00475133046717015 1.44869994779485 0 0 0.000320692802708327 0.999578183658835 0.999224402000993 0.999797704727851 1 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Glu230Lys glpK_p.Glu230Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Glu238Ala glpK_p.Glu238Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Glu238Gly glpK_p.Glu238Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Glu276Gly glpK_p.Glu276Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 5 0 16805 30532 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 1 0.999879187193184 1 1 0.478176249895018 1 1 0.025 1 1 0.025 1 Inf 0.0465826842950206 Inf 0.355021335924627 388 4649 False False Inf 1.66460481015123 Inf 5.95025586100202e-05 1.50647321873052e-06 0.000331481949204222 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.052853655209362 Inf 0.326658713928652 320 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 8.69489609599165e-05 2.20135467503192e-06 0.000484352330576856 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Glu276Lys glpK_p.Glu276Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Glu320Lys glpK_p.Glu320Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4261 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3564 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Glu347Ala glpK_p.Glu347Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4189 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3509 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Glu38Gly glpK_p.Glu38Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4116 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Glu413Lys glpK_p.Glu413Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Glu495Gly glpK_p.Glu495Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Glu57Asp glpK_p.Glu57Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Glu65Gly glpK_p.Glu65Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Glu8Gly glpK_p.Glu8Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4199 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3514 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Gly105Glu glpK_p.Gly105Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4218 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3528 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Gly161Arg glpK_p.Gly161Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4206 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3517 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Gly161Glu glpK_p.Gly161Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4219 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Gly169Arg glpK_p.Gly169Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4238 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3544 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Gly187Glu glpK_p.Gly187Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4131 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Gly191dup glpK_p.Gly191dup 2 inframe_insertion (see "Genomic_coordinates" sheet) NA 0 0 0 2 37 16808 30495 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.998788156688065 0.998330016628398 0.999146611401903 0.0512820512820512 0.00627197209569041 0.173244781373605 NA NA NA 0 0 0.0948905874149899 NA NA NA NA 4220 4649 False True 0.0980710601129449 0.0114408616863693 0.380280302129761 0 0 0.000219447565534303 0.998788156688065 0.998330016628398 0.999146611401903 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 2 30 11500 23677 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.998734550976504 0.998193981604752 0.999146049059161 0.0625 0.00766073634645639 0.208069429895007 NA NA NA 0 0 0.115703308222027 NA NA NA NA 3529 3890 False True 0 1 1 0 0 0 0 0.137257971014492 0.0158792540284305 0.541133847059504 0 0 0.000320720684566658 0.998734550976504 0.998193981604752 0.999146049059161 6 5) Not assoc w R New NotAwR yes 5 +Rifampicin glpK p.Gly191fs glpK_p.Gly191fs 2 frameshift (see "Genomic_coordinates" sheet) 1 21 2 19 8 23 16802 30509 0.000475907198096371 0.00020548462525215 0.000937510381255989 0.999246691995283 0.998869881214224 0.999522409302755 0.258064516129032 0.118563995829551 0.446133934334896 0.0952380952380952 0.0117493178844458 0.303774406913924 0.08 0.00983959001879751 0.260305842105214 0.19113639353711 0.0215868434073669 0.792442330141379 0.0112097437153253 109 4649 False False 0.631581126470451 0.24417124663564 1.4630197232335 0.000119019281123542 1.44141121218677e-05 0.000429871733373253 0.999246691995283 0.998869881214224 0.999522409302755 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 2 9 5 13 11497 23694 0.00043470700747696 0.000141162766530747 0.00101416710312943 0.999451638756485 0.999062468123692 0.999707989454911 0.277777777777777 0.0969492125255593 0.534801965583056 0.181818181818181 0.0228311982999596 0.517755852360172 0.133333333333333 0.0165759134400836 0.404602696603372 0.457974544083963 0.0481472269845631 2.21319831553673 0.521113686919018 361 3890 False False 0 0 0 0 0 0 0 0.792648249376091 0.2211985711168 2.36995309353315 0.000173928167666753 2.10642020967855e-05 0.000628145625606295 0.999451638756485 0.999062468123692 0.999707989454911 4 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Gly23Asp glpK_p.Gly23Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4248 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3552 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Gly23Val glpK_p.Gly23Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Gly247Arg glpK_p.Gly247Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4221 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3530 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Gly247Trp glpK_p.Gly247Trp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4135 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3469 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Gly250Asp glpK_p.Gly250Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Gly260Ala glpK_p.Gly260Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 43 16810 30489 0 0 0.000219421459229958 0.998591641556399 0.998103414035026 0.998980582310685 0 0 0.0822111211541385 NA NA NA 0 0 0.0822111211541385 NA NA NA NA 4090 4649 False True 0 0 0.162514550038803 0 0 0.000219421459229958 0.998591641556399 0.998103414035026 0.998980582310685 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 42 11502 23665 0 0 0.000320664925697395 0.998228371367106 0.997606018992145 0.998722876779403 0 0 0.0840838549403552 NA NA NA 0 0 0.0840838549403552 NA NA NA NA 3436 3890 False True 1 1 1 0 0 0 0 0 0 0.188921536086752 0 0 0.000320664925697395 0.998228371367106 0.997606018992145 0.998722876779403 3 5) Not assoc w R New NotAwR yes 5 +Rifampicin glpK p.Gly292Ser glpK_p.Gly292Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4207 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3518 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Gly301Cys glpK_p.Gly301Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4122 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3459 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Gly301Val glpK_p.Gly301Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 80.2910622977969 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Gly311Glu glpK_p.Gly311Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Gly338Asp glpK_p.Gly338Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Gly342dup glpK_p.Gly342dup 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 4.39540875925228 0.556930310247326 910.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Gly357Ser glpK_p.Gly357Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Gly36Ser glpK_p.Gly36Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4239 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3545 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Gly379Ser glpK_p.Gly379Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4190 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Gly417fs glpK_p.Gly417fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Gly417Ser glpK_p.Gly417Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4254 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3558 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Gly427Ser glpK_p.Gly427Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Gly465Ala glpK_p.Gly465Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Gly469Arg glpK_p.Gly469Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4182 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3506 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Gly499fs glpK_p.Gly499fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Gly54Ser glpK_p.Gly54Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4191 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3510 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Gly89Ala glpK_p.Gly89Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Gly89Glu glpK_p.Gly89Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4229 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3538 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.His103Arg glpK_p.His103Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.His103Asn glpK_p.His103Asn 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4152 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.His103Tyr glpK_p.His103Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4171 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3498 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.His193fs glpK_p.His193fs 2 frameshift (see "Genomic_coordinates" sheet) 1 5 0 5 2 8 16808 30524 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999737979824446 0.999483781433772 0.999886871715824 0.2 0.0252107263268333 0.556095462307641 0 0 0.521823750104981 0 0 0.369416647552819 0 0 1.98206417469311 0.168450093725646 264 4649 False False 0.454009995240361 0.0469649977420217 2.27541152741616 0 0 0.000219447565534303 0.999737979824446 0.999483781433772 0.999886871715824 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 0 0 0.841886116991581 0 0 0.521823750104981 0 0 10.970403447915 1 504 3890 False False 0 0 0 0 0 0 0 0 0 2.24912710990902 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 1 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.His35Tyr glpK_p.His35Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.His392Gln glpK_p.His392Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4242 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.His42Asp glpK_p.His42Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4240 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3546 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.His42Tyr glpK_p.His42Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4158 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3488 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.His58Arg glpK_p.His58Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4091 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3437 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ile112Val glpK_p.Ile112Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4200 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ile122Val glpK_p.Ile122Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ile223Thr glpK_p.Ile223Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4117 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ile255Leu glpK_p.Ile255Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 2 1 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 3.6329128986197 0.189104318453829 214.057761575796 0.28869722941154 292 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.387090251295738 Inf 0.10671216244731 152.5 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ile323Val glpK_p.Ile323Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4192 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ile401Met glpK_p.Ile401Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ile429Thr glpK_p.Ile429Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4211 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3522 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ile49Thr glpK_p.Ile49Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 80.2910622977969 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ile5Leu glpK_p.Ile5Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4258 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3561 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ile5Met glpK_p.Ile5Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ile5Thr glpK_p.Ile5Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4140 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ile85Thr glpK_p.Ile85Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4163 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3491 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ile90fs glpK_p.Ile90fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4107 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ile90Thr glpK_p.Ile90Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Leu126Met glpK_p.Leu126Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4262 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3565 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Leu141Met glpK_p.Leu141Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Leu152Arg glpK_p.Leu152Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4118 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3456 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Leu152Val glpK_p.Leu152Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4267 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Leu156Val glpK_p.Leu156Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Leu172Phe glpK_p.Leu172Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Leu205Val glpK_p.Leu205Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Leu218Val glpK_p.Leu218Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4141 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3474 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Leu228Ala glpK_p.Leu228Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4123 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3460 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Leu228Val glpK_p.Leu228Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 14 503 16796 30029 0.000832837596668649 0.000455392489979272 0.00139696554892221 0.983525481462072 0.982034390933941 0.984923517633274 0.0270793036750483 0.0148818673821691 0.0450174016988137 NA NA NA 0 0 0.00730692999817794 NA NA NA NA 4263 4649 False True 0.0497616823469755 0.0269969744702317 0.0843065702118262 0 0 0.000219604333908644 0.983525481462072 0.982034390933941 0.984923517633274 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 11 345 11491 23362 0.000956355416449313 0.000477502787107626 0.00171053820723243 0.985447336229805 0.983840901967994 0.986933085412822 0.0308988764044943 0.015523505816417 0.0546131061716426 NA NA NA 0 0 0.0106354436567444 NA NA NA NA 3566 3890 False True 1 1 1 0 0 0 0 0.0648225012896041 0.0320564988800562 0.117498153816338 0 0 0.000320971839633333 0.985447336229805 0.983840901967994 0.986933085412822 2 5) Not assoc w R New NotAwR yes 5 +Rifampicin glpK p.Leu259Phe glpK_p.Leu259Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Leu272Val glpK_p.Leu272Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Leu287Pro glpK_p.Leu287Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4179 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3505 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Leu289Arg glpK_p.Leu289Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4249 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3553 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Leu319Arg glpK_p.Leu319Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4183 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Leu333Ile glpK_p.Leu333Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 1 8 16809 30524 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999737979824446 0.999483781433772 0.999886871715824 0.111111111111111 0.00280913674659921 0.482496514917337 0 0 0.409616397225003 0 0 0.369416647552819 0 0 1.26010436574317 0.0561499502421887 160 4649 False False 0.226991492652745 0.00511932236302294 1.69341645046941 0 0 0.000219434511605659 0.999737979824446 0.999483781433772 0.999886871715824 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 1 8 11501 23699 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999662546927068 0.999335191784523 0.999854300817065 0.111111111111111 0.00280913674659921 0.482496514917337 0 0 0.409616397225003 0 0 0.369416647552819 0 0 1.42993789808289 0.104256245416693 139.5 3890 False False 0 0 0 0 0 0 0 0.257575428223632 0.00580827991067691 1.92165917942206 0 0 0.000320692802708327 0.999662546927068 0.999335191784523 0.999854300817065 2 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Leu337fs glpK_p.Leu337fs 2 frameshift (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Leu349Pro glpK_p.Leu349Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Leu393Val glpK_p.Leu393Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4172 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3499 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Leu398Met glpK_p.Leu398Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4224 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3532 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Leu398Pro glpK_p.Leu398Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4208 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3519 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Leu420Met glpK_p.Leu420Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Leu423Phe glpK_p.Leu423Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4146 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3478 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Leu44Arg glpK_p.Leu44Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4255 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3559 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Leu466Phe glpK_p.Leu466Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 11 3 16799 30529 0.00065437239738251 0.000326704163498642 0.00117055062018267 0.999901742434167 0.999712876815577 0.99997973646933 0.785714285714285 0.492024322951528 0.953420712110132 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.39843178353086 0.556910504102044 768 4649 False False 6.6634720320654 1.75984687194931 37.2004360275228 0 0 0.000219565120820351 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 8 3 11494 23704 0.000695531211963136 0.000300327312744212 0.00137001129783907 0.99987345509765 0.999630227076139 0.999973902638554 0.727272727272727 0.390257440427578 0.939782265827093 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.99172154655264 0.555676444976733 485.5 3890 False False 0 0 0 0 0 0 0 5.49944898787773 1.31956246574254 32.1907740650698 0 0 0.000320888077582845 0.99987345509765 0.999630227076139 0.999973902638554 1 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Lys83Glu glpK_p.Lys83Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 4129 4649 False False 0 0 1.9820231071276 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3464 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Met1? glpK_p.Met1? 2 start_lost (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4250 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3554 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Met206Ile glpK_p.Met206Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4173 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3500 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Met227Ile glpK_p.Met227Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.75142405620251 0.304356294847217 327.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12235036001139 0.310791984491028 261 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Met266fs glpK_p.Met266fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Met30Val glpK_p.Met30Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4243 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3548 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Met359Ile glpK_p.Met359Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Met412Ile glpK_p.Met412Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 1 6 1 6 16809 30526 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999803484868334 0.999572318737888 0.999927879105266 0.142857142857142 0.00361029686190058 0.578723197043195 0.142857142857142 0.00361029686190058 0.578723197043195 0.142857142857142 0.00361029686190058 0.578723197043195 0.302675154183274 0.00658396461982027 2.49513982006856 0.43350822712212 444 4649 False False 0.302675154183274 0.00658396461982027 2.49513982006856 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999803484868334 0.999572318737888 0.999927879105266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12235036001139 0.310791984491028 261 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Met412Thr glpK_p.Met412Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4230 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Met412Val glpK_p.Met412Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4153 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Phe147Leu glpK_p.Phe147Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Phe16Leu glpK_p.Phe16Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4108 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3449 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Phe16Ser glpK_p.Phe16Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Phe173Tyr glpK_p.Phe173Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Phe32Cys glpK_p.Phe32Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4231 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3539 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Phe365Leu glpK_p.Phe365Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 9.67028206568003 0.541992006917746 476.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Phe369Leu glpK_p.Phe369Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Phe470Leu glpK_p.Phe470Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Pro142Ser glpK_p.Pro142Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4130 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3465 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Pro143Ser glpK_p.Pro143Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Pro143Thr glpK_p.Pro143Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Pro176Leu glpK_p.Pro176Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4101 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Pro176Ser glpK_p.Pro176Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Pro236Ala glpK_p.Pro236Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4164 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3492 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Pro239Arg glpK_p.Pro239Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4174 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3501 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Pro239Ser glpK_p.Pro239Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Pro248Ser glpK_p.Pro248Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4147 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3479 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Pro254fs glpK_p.Pro254fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4096 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3441 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Pro254Gln glpK_p.Pro254Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Pro254Leu glpK_p.Pro254Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Pro254Ser glpK_p.Pro254Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4268 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Pro274Leu glpK_p.Pro274Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 16809 30529 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999901742434167 0.999712876815577 0.99997973646933 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.39581433818102 0.556927644280045 795 4649 False False 0.605409800305391 0.0115361654751757 7.54087213596152 0 0 0.000219434511605659 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Pro315Leu glpK_p.Pro315Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 3 4 16807 30528 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999868989912223 0.999664596427238 0.999964303043777 0.428571428571428 0.0989882784425078 0.815948432359917 0.333333333333333 0.00840375865961264 0.905700675949754 0.2 0.00505076337946806 0.716417936118089 0.908193014815255 0.0153982235485777 17.4470461941903 1 1627.5 4649 False False 1.36228952222288 0.19952864446048 8.05486976701789 5.94954783436458e-05 1.50629396217601e-06 0.000331442511213996 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 3 3 11499 23704 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.99987345509765 0.999630227076139 0.999973902638554 0.5 0.118117248757025 0.881882751242974 0.333333333333333 0.00840375865961264 0.905700675949754 0.25 0.00630946320970987 0.805879550316756 1.03069832159318 0.0174740135756451 19.8083325825012 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06139664318636 0.276050319534324 15.3984166853777 8.69565217391304e-05 2.20154609696687e-06 0.000484394439799471 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Pro354Ser glpK_p.Pro354Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Pro354Thr glpK_p.Pro354Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Pro363Arg glpK_p.Pro363Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4205 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Pro363Ser glpK_p.Pro363Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4175 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3502 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Pro371Ser glpK_p.Pro371Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4184 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Pro474Ala glpK_p.Pro474Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Pro474Leu glpK_p.Pro474Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 3 2 16807 30530 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999934494956111 0.999763393503742 0.99999206693684 0.6 0.146632799634673 0.947255049473683 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.67232174050862 0.542020050820051 749.5 4649 False False 2.72475754150056 0.312074221533576 32.6324551811023 0 0 0.000219460621016169 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 3 2 11499 23705 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.999915636731767 0.999695284447545 0.999989783053538 0.6 0.146632799634673 0.947255049473683 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.9746468441883 1 1214.5 3890 False False 0 0 0 0 0 0 0 3.09222541090529 0.354154889835857 37.0377673791385 0 0 0.000320748571273651 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Pro489Arg glpK_p.Pro489Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4159 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Pro51Ala glpK_p.Pro51Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4232 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Pro51Leu glpK_p.Pro51Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Pro82Leu glpK_p.Pro82Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4092 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3438 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ser124Leu glpK_p.Ser124Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ser124Pro glpK_p.Ser124Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 2 1 2 3 16808 30529 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999901742434167 0.999712876815577 0.99997973646933 0.4 0.0527449505263169 0.853367200365326 0.666666666666666 0.0942993240502461 0.991596241340387 0.4 0.0527449505263169 0.853367200365326 3.63267491670633 0.189091929877226 214.04376028135 0.288717841013158 294 4649 False False 1.21089163890211 0.101157890363798 10.5697741171107 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3493 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 1 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ser13Pro glpK_p.Ser13Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ser237Ala glpK_p.Ser237Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4185 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3507 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ser26Arg glpK_p.Ser26Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4176 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3503 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ser2fs glpK_p.Ser2fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ser2Phe glpK_p.Ser2Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ser2Thr glpK_p.Ser2Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ser375Phe glpK_p.Ser375Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4154 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3484 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ser416Ala glpK_p.Ser416Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4256 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3560 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ser416Tyr glpK_p.Ser416Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 4 2 16806 30530 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999934494956111 0.999763393503742 0.99999206693684 0.666666666666666 0.222778095503512 0.956728131707258 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.67289635744665 0.542027951562172 754 4649 False False 3.63322622872783 0.520625747830046 40.1764939558657 0 0 0.000219473678051534 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 80.2910622977969 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ser517Cys glpK_p.Ser517Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4264 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3567 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Ser73Trp glpK_p.Ser73Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Thr117Ile glpK_p.Thr117Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Thr185Ile glpK_p.Thr185Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4193 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Thr195fs glpK_p.Thr195fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4142 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3475 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Thr203Ala glpK_p.Thr203Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4244 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3549 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Thr243Lys glpK_p.Thr243Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4225 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3533 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Thr24Ala glpK_p.Thr24Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4241 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3547 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Thr256Ile glpK_p.Thr256Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4136 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3470 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Thr280Ala glpK_p.Thr280Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Thr280Asn glpK_p.Thr280Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4201 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3515 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Thr283fs glpK_p.Thr283fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4148 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3480 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Thr291Asn glpK_p.Thr291Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4245 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3550 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Thr294Met glpK_p.Thr294Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4226 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Thr326Ala glpK_p.Thr326Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4194 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Thr326fs glpK_p.Thr326fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4233 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Thr326Ser glpK_p.Thr326Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Thr397Ala glpK_p.Thr397Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 3 2 16807 30530 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999934494956111 0.999763393503742 0.99999206693684 0.6 0.146632799634673 0.947255049473683 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.908252513833521 0.0153992319558821 17.4481890566664 1 1627.5 4649 False False 2.72475754150056 0.312074221533576 32.6324551811023 5.94954783436458e-05 1.50629396217601e-06 0.000331442511213996 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Thr397Met glpK_p.Thr397Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Thr430Ala glpK_p.Thr430Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 36 0 36 3 43 16807 30489 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.998591641556399 0.998103414035026 0.998980582310685 0.0652173913043478 0.0136567719134455 0.178964388872751 0 0 0.0973937559144919 0 0 0.0822111211541385 0 0 0.195803503502632 1.77564678809273e-07 28 4649 True False 0.126562714040799 0.025113658039318 0.39554024070213 0 0 0.000219460621016169 0.998591641556399 0.998103414035026 0.998980582310685 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 26 0 26 2 30 11500 23677 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.998734550976504 0.998193981604752 0.999146049059161 0.0625 0.00766073634645639 0.208069429895007 0 0 0.132274604497754 0 0 0.115703308222027 0 0 0.313932255709277 6.27877995217882e-05 37 3890 True False 0 0 0 0 0 0 0 0.137257971014492 0.0158792540284305 0.541133847059504 0 0 0.000320720684566658 0.998734550976504 0.998193981604752 0.999146049059161 6 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Thr430Ser glpK_p.Thr430Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 4137 4649 False False Inf 1.1990579265185 Inf 0 0 0.000219473678051534 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 11498 23707 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 1 0.999844409142079 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3471 3890 False False 0 0 0 0 0 0 0 Inf 1.3608069907404 Inf 0 0 0.000320776462830572 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Thr455fs glpK_p.Thr455fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0465715996825058 Inf 0.355075831185839 416 4649 False False Inf 0.0465715996825058 Inf 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Thr488Ile glpK_p.Thr488Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Thr490Met glpK_p.Thr490Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Thr490Ser glpK_p.Thr490Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.9820231071276 0.168448731581911 252 4649 False False 0 0 1.9820231071276 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 2.24912710990902 0.180424970179968 177 3890 False False 0 0 0 0 0 0 0 0 0 2.24912710990902 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Thr510Ile glpK_p.Thr510Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4149 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3481 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Thr78Ala glpK_p.Thr78Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4180 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Thr91Ala glpK_p.Thr91Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4155 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3485 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Thr97fs glpK_p.Thr97fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4102 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3445 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Trp100fs glpK_p.Trp100fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4251 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3555 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Trp114Arg glpK_p.Trp114Arg 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4160 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Trp114* glpK_p.Trp114* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Trp213* glpK_p.Trp213* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0465715996825058 Inf 0.355075831185839 416 4649 False False Inf 0.0465715996825058 Inf 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0528490600080728 Inf 0.32667783805277 340.5 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Trp332Arg glpK_p.Trp332Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Trp471Cys glpK_p.Trp471Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4234 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3540 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Trp487fs glpK_p.Trp487fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Trp513Arg glpK_p.Trp513Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 3 1 16807 30531 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999967247478055 0.999817528289014 0.999999170778282 0.75 0.194120449683243 0.99369053679029 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.8165645266853 0.0231403942884232 142.442654469459 1 1627.5 4649 False False 5.44969358005592 0.437509494081317 285.652299683162 5.94954783436458e-05 1.50629396217601e-06 0.000331442511213996 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 80.2910622977969 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Trp64Leu glpK_p.Trp64Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Tyr109Cys glpK_p.Tyr109Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Tyr281* glpK_p.Tyr281* 2 stop_gained (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.67117271135833 0.542004252564565 721 4649 False False 0.908144446427509 0.0153974005043644 17.4461131425891 0 0 0.000219434511605659 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3534 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Tyr308His glpK_p.Tyr308His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3570 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Tyr317His glpK_p.Tyr317His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0465715996825058 Inf 0.355075831185839 416 4649 False False Inf 0.0465715996825058 Inf 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0528490600080728 Inf 0.32667783805277 340.5 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Tyr372Cys glpK_p.Tyr372Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4222 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3531 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Tyr372fs glpK_p.Tyr372fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Tyr462fs glpK_p.Tyr462fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4109 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Tyr500Cys glpK_p.Tyr500Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Val113Ala glpK_p.Val113Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4212 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Val113Ile glpK_p.Val113Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Val159Ile glpK_p.Val159Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Val162Leu glpK_p.Val162Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Val192fs glpK_p.Val192fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 328 165 16482 30367 0.0195121951219512 0.0174749792880658 0.021717953235252 0.994595833879208 0.993708236223889 0.995387215715767 0.665314401622718 0.621749047612873 0.706882740625449 NA NA NA 0 0 0.022108782981671 NA NA NA NA 4213 4649 False True 3.66253580581938 3.02535266557484 4.44742597797859 0 0 0.000223787566802474 0.994595833879208 0.993708236223889 0.995387215715767 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 173 115 11329 23592 0.0150408624587028 0.0128964223962606 0.0174355938687392 0.995149112076601 0.994180075597384 0.995993482504943 0.600694444444444 0.541597434150643 0.657697208419312 NA NA NA 0 0 0.0315681959882471 NA NA NA NA 3523 3890 False True 0 1 1 0 0 0 0 3.13271903195723 2.45740000212369 4.00546597031998 0 0 0.000325560856575972 0.995149112076601 0.994180075597384 0.995993482504943 120 5) Not assoc w R New NotAwR yes 5 +Rifampicin glpK p.Val192Met glpK_p.Val192Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4124 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Val253Leu glpK_p.Val253Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.75142405620251 0.304356294847217 327.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12235036001139 0.310791984491028 261 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 1 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Val267Ile glpK_p.Val267Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4110 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Val270Phe glpK_p.Val270Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4235 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3541 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Val296Ala glpK_p.Val296Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Val296Met glpK_p.Val296Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4252 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3556 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Val325Met glpK_p.Val325Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Val330Leu glpK_p.Val330Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4165 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3494 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Val353Ala glpK_p.Val353Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4166 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Val353Phe glpK_p.Val353Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4103 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Val362Ala glpK_p.Val362Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Val382Ala glpK_p.Val382Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Val39Ala glpK_p.Val39Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Val39Leu glpK_p.Val39Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.75142405620251 0.304356294847217 327.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Val408Leu glpK_p.Val408Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4097 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3442 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Val418Asp glpK_p.Val418Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Val422Met glpK_p.Val422Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4269 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3571 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Val425Ala glpK_p.Val425Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4143 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3476 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Val442Met glpK_p.Val442Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Val452Leu glpK_p.Val452Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4253 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Val460Ala glpK_p.Val460Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 556 4064 16254 26468 0.0330755502676978 0.0304234248583132 0.0358907828426244 0.866893750818813 0.863032213836534 0.870685335238287 0.12034632034632 0.111098127208155 0.130077283904083 NA NA NA 0 0 0.000907284884022782 NA NA NA NA 4202 4649 False True 0.222782956394016 0.203088789444562 0.244049937310942 0 0 0.000226926349594423 0.866893750818813 0.863032213836534 0.870685335238287 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 404 3310 11098 20397 0.0351243262041384 0.0318346164151954 0.0386519466157836 0.860378791074366 0.855901576858371 0.864767459006169 0.10877759827679 0.098940143240162 0.119235365612123 NA NA NA 0 0 0.00111384430629285 NA NA NA NA 3516 3890 False True 0 1 1 0 0 0 0 0.224323590053786 0.201286541072009 0.249509422274784 0 0 0.000332336136797856 0.860378791074366 0.855901576858371 0.864767459006169 447 5) Not assoc w R New NotAwR yes 5 +Rifampicin glpK p.Val460Met glpK_p.Val460Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4259 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3562 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Val468Ile glpK_p.Val468Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin glpK p.Val99Ala glpK_p.Val99Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4098 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB c.1002C>T lpqB_c.1002C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1011C>A lpqB_c.1011C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1011C>T lpqB_c.1011C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1020C>T lpqB_c.1020C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1023A>G lpqB_c.1023A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1032G>A lpqB_c.1032G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.341150751115529 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1047C>A lpqB_c.1047C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1047C>T lpqB_c.1047C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1050C>G lpqB_c.1050C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 2 16808 30530 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999934494956111 0.999763393503742 0.99999206693684 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.8163969538315 0.131636449523742 25.0652602654423 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 2 11500 23705 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999915636731767 0.999695284447545 0.999989783053538 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06130434782608 0.149383229063395 28.4413197127326 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1050C>T lpqB_c.1050C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1059C>T lpqB_c.1059C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.105G>A lpqB_c.105G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1077C>G lpqB_c.1077C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1086G>A lpqB_c.1086G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1092G>A lpqB_c.1092G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1098C>T lpqB_c.1098C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1101G>T lpqB_c.1101G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1104T>G lpqB_c.1104T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1107G>A lpqB_c.1107G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1107G>T lpqB_c.1107G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1119G>T lpqB_c.1119G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.111G>C lpqB_c.111G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1125G>A lpqB_c.1125G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.908144446427509 0.0153974005043644 17.4461131425891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1146C>T lpqB_c.1146C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.341150751115529 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1161C>A lpqB_c.1161C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1167C>T lpqB_c.1167C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1176C>T lpqB_c.1176C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.117G>A lpqB_c.117G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.908144446427509 0.0153974005043644 17.4461131425891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1182G>A lpqB_c.1182G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1188C>T lpqB_c.1188C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1230C>G lpqB_c.1230C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1230C>T lpqB_c.1230C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1236C>G lpqB_c.1236C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1236C>T lpqB_c.1236C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.123A>G lpqB_c.123A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.9820231071276 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1263A>C lpqB_c.1263A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.126G>A lpqB_c.126G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1275C>T lpqB_c.1275C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 7 16809 30525 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.99977073234639 0.999527678427408 0.999907817703152 0.125 0.0031597235312519 0.526509670875206 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.2594273475944 0.00575995110596449 2.01970184240593 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.24912710990902 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1302G>T lpqB_c.1302G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 26 58 16784 30474 0.0015466983938132 0.00101059577405045 0.00226545603351431 0.998100353727237 0.997544949665314 0.998557212644086 0.309523809523809 0.213140074827681 0.419795965877292 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.813915551757009 0.491604967635258 1.31426494457382 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 13 47 11489 23660 0.00113023821944009 0.000601937155487611 0.00193196626494298 0.998017463196524 0.99736450840227 0.998542954015614 0.216666666666666 0.120716024462696 0.341956178734652 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 0 0.56961052477578 0.282633025575798 1.07070383229075 NA NA NA NA NA NA 4 5) Not assoc w R Now listed Silent mutation no 0 +Rifampicin lpqB c.1320G>A lpqB_c.1320G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1320G>T lpqB_c.1320G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1326G>A lpqB_c.1326G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1342C>T lpqB_c.1342C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.341150751115529 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1383G>C lpqB_c.1383G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1389G>T lpqB_c.1389G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1398C>A lpqB_c.1398C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1404C>T lpqB_c.1404C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1413C>G lpqB_c.1413C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 9 16810 30523 0 0 0.000219421459229958 0.999705227302502 0.999440503684993 0.999865202576615 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.920078094923294 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 9 11502 23698 0 0 0.000320664925697395 0.999620365292951 0.999279457952852 0.99982639261309 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.04405446176545 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1416G>A lpqB_c.1416G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 8 16810 30524 0 0 0.000219421459229958 0.999737979824446 0.999483781433772 0.999886871715824 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.06393155676265 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 7 11502 23700 0 0 0.000320664925697395 0.999704728561184 0.999391723222185 0.999881277590374 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.42986888806462 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1419T>G lpqB_c.1419T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1422C>T lpqB_c.1422C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1425G>A lpqB_c.1425G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1428C>T lpqB_c.1428C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1443T>C lpqB_c.1443T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1443T>G lpqB_c.1443T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1446G>A lpqB_c.1446G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1449G>A lpqB_c.1449G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1452G>A lpqB_c.1452G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 10 3 16800 30529 0.000594883997620464 0.000285305684944214 0.00109373983334496 0.999901742434167 0.999712876815577 0.99997973646933 0.769230769230769 0.461868460765959 0.949618926508848 NA NA NA NA NA NA NA NA NA NA NA NA False False 6.05734126984126 1.55931702668942 34.2318335698778 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1464G>A lpqB_c.1464G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1473G>A lpqB_c.1473G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.341150751115529 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1473G>T lpqB_c.1473G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1476G>A lpqB_c.1476G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 7 14 16803 30518 0.000416418798334324 0.000167437820935922 0.000857792460925722 0.999541464692781 0.999230775228684 0.999749292529582 0.333333333333333 0.145876942343096 0.569675482904124 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.90811164672975 0.310130014435218 2.40490896403654 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 7 13 11495 23694 0.000608589810467744 0.000244718560881119 0.00125352303681455 0.999451638756485 0.999062468123692 0.999707989454911 0.35 0.153909204784541 0.592188534532828 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.10990062569009 0.374870723070924 2.99415356125132 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1488C>G lpqB_c.1488C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1488C>T lpqB_c.1488C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1497C>T lpqB_c.1497C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1503C>T lpqB_c.1503C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.150G>A lpqB_c.150G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1515G>A lpqB_c.1515G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1518A>G lpqB_c.1518A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 25 7 16785 30525 0.00148720999405116 0.000962667916776425 0.00219463783814356 0.99977073234639 0.999527678427408 0.999907817703152 0.78125 0.600271736287892 0.90722846771528 NA NA NA NA NA NA NA NA NA NA NA NA False False 6.49495723222264 2.72994727681148 17.7839945356193 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 25 6 11477 23701 0.0021735350373848 0.00140707589428017 0.00320690572089761 0.9997469101953 0.999449212060655 0.99990711502044 0.806451612903225 0.625267833893415 0.925480102688871 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 8.60452789637245 3.44428945939226 25.6654455097802 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1524C>A lpqB_c.1524C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1527C>T lpqB_c.1527C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1530C>T lpqB_c.1530C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1539G>A lpqB_c.1539G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1539G>C lpqB_c.1539G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 69 16809 30463 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.99774007598585 0.997140780062205 0.99824123174651 0.0142857142857142 0.000361617571803165 0.0770437623367664 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.0262652598978635 0.00066014470144588 0.151330050328054 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 0 67 11502 23640 0 0 0.000320664925697395 0.997173830514194 0.996412234433144 0.997809106640521 0 0 0.0535696541270968 NA NA NA NA NA NA NA NA NA NA NA NA False True 1 1 1 0 0 0 0 0 0 0.116387352812388 NA NA NA NA NA NA 4 5) Not assoc w R Now listed Silent mutation no 0 +Rifampicin lpqB c.1542G>A lpqB_c.1542G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.154T>C lpqB_c.154T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.6329128986197 0.189104318453829 214.057761575796 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1554C>T lpqB_c.1554C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1560C>T lpqB_c.1560C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.156A>G lpqB_c.156A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1575C>T lpqB_c.1575C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1587C>T lpqB_c.1587C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1590G>A lpqB_c.1590G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.159C>A lpqB_c.159C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.159C>T lpqB_c.159C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1617G>A lpqB_c.1617G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1620C>A lpqB_c.1620C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 29 13 16781 30519 0.00172516359309934 0.00115566411224569 0.00247669038907857 0.999574217214725 0.999272008529012 0.999773269742809 0.69047619047619 0.529139371067883 0.823778917358044 NA NA NA NA NA NA NA NA NA NA NA NA False False 4.0570196146741 2.04303350897144 8.50352888665443 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 22 12 11480 23695 0.00191271083289862 0.00119906180010764 0.00289444346770694 0.999493820390602 0.999115973206486 0.999738423129043 0.647058823529411 0.464886370891042 0.802541352087657 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.78404471544715 1.79233368882059 8.39164863240381 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1629G>A lpqB_c.1629G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.162G>A lpqB_c.162G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1632T>C lpqB_c.1632T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.341150751115529 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1635G>A lpqB_c.1635G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.1990579265185 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1644C>T lpqB_c.1644C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1680C>G lpqB_c.1680C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1689A>G lpqB_c.1689A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 583 57 16227 30475 0.034681737061273 0.031966767990432 0.0375591999753961 0.998133106249181 0.997581890224125 0.998585735663127 0.9109375 0.886148409865076 0.931847820831776 NA NA NA NA NA NA NA NA NA NA NA NA False False 19.2087532258884 14.6062714726439 25.7081786692732 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 551 52 10951 23655 0.047904712223961 0.04407316648044 0.0519670972215522 0.997806555025941 0.997124571279164 0.998361409801279 0.913764510779436 0.888450605017411 0.934925876380413 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 22.8885050891032 17.1892957125189 31.063664331013 NA NA NA NA NA NA 30 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1695C>T lpqB_c.1695C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.16T>C lpqB_c.16T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 3 16809 30529 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999901742434167 0.999712876815577 0.99997973646933 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.605409800305391 0.0115361654751757 7.54087213596152 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1710G>A lpqB_c.1710G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.9820231071276 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1710G>T lpqB_c.1710G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1716G>A lpqB_c.1716G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.171G>A lpqB_c.171G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1722G>T lpqB_c.1722G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1725G>A lpqB_c.1725G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1737G>C lpqB_c.1737G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 6 16806 30526 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999803484868334 0.999572318737888 0.999927879105266 0.4 0.121552258119827 0.737621923393055 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.21091673608631 0.25129786177201 5.10706056868951 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1740A>G lpqB_c.1740A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1741T>C lpqB_c.1741T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1743G>A lpqB_c.1743G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.1746C>G lpqB_c.1746C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.174C>T lpqB_c.174C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.189C>G lpqB_c.189C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.189C>T lpqB_c.189C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 5 13 16805 30519 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 0.999574217214725 0.999272008529012 0.999773269742809 0.277777777777777 0.0969492125255593 0.534801965583056 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.698487171858192 0.194937400030589 2.08826792644882 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 11 11499 23696 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.999536002024718 0.999169931473241 0.999768351851939 0.214285714285714 0.0465792878898673 0.507975677048471 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.562009344686099 0.100646994477913 2.12814636090958 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.18G>A lpqB_c.18G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 11 16809 30521 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999639722258614 0.999355455254591 0.999820137367966 0.0833333333333333 0.00210759323186022 0.384796165150944 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.165068496855039 0.00383877950020004 1.13592616933053 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.195G>A lpqB_c.195G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.195G>C lpqB_c.195G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.201G>A lpqB_c.201G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 8 223 16802 30309 0.000475907198096371 0.00020548462525215 0.000937510381255989 0.992696187606445 0.991676305854216 0.993620558436501 0.0346320346320346 0.0150680687500484 0.0670959635765896 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.06471362847579 0.0276077851270562 0.129811127844309 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 7 209 11495 23498 0.000608589810467744 0.000244718560881119 0.00125352303681455 0.99118403846965 0.989910821915347 0.992334536566684 0.0324074074074074 0.0131268410816301 0.0656289820034897 NA NA NA NA NA NA NA NA NA NA NA NA False True 1 1 1 0 0 0 0 0.0684657985269235 0.0271865811505178 0.143673307690831 NA NA NA NA NA NA 12 5) Not assoc w R Now listed Silent mutation no 0 +Rifampicin lpqB c.201G>C lpqB_c.201G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.750576632084797 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.204G>A lpqB_c.204G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.240C>G lpqB_c.240C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.261G>T lpqB_c.261G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.264G>A lpqB_c.264G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.270C>T lpqB_c.270C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.273C>T lpqB_c.273C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.279G>A lpqB_c.279G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.315G>A lpqB_c.315G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.318G>A lpqB_c.318G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 6 275 16804 30257 0.000356930398572278 0.000130998068917797 0.000776724091447791 0.990993056465348 0.989868899579531 0.992022237580341 0.0213523131672597 0.00787528462240251 0.0458932588685615 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.0392854515158728 0.0142858722418994 0.0866103019136514 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 5 251 11497 23456 0.00043470700747696 0.000141162766530747 0.00101416710312943 0.989412409836757 0.988026696588067 0.990676085882877 0.01953125 0.00637142045480582 0.0449883211163743 NA NA NA NA NA NA NA NA NA NA NA NA False True 1 1 1 0 0 0 0 0.0406411234248879 0.0130672119115856 0.096157102132655 NA NA NA NA NA NA 18 5) Not assoc w R Now listed Silent mutation no 0 +Rifampicin lpqB c.321C>A lpqB_c.321C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.321C>T lpqB_c.321C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.333C>T lpqB_c.333C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.33A>G lpqB_c.33A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.342C>T lpqB_c.342C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.354T>C lpqB_c.354T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.372C>T lpqB_c.372C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.399C>A lpqB_c.399C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.429T>C lpqB_c.429T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.435C>T lpqB_c.435C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.453C>T lpqB_c.453C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.456G>A lpqB_c.456G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.468C>T lpqB_c.468C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.477G>A lpqB_c.477G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.504C>T lpqB_c.504C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 9 16809 30523 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999705227302502 0.999440503684993 0.999865202576615 0.1 0.00252857854446178 0.445016117028195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.201763605475902 0.00460699063398853 1.45637661246692 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 7 11501 23700 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999704728561184 0.999391723222185 0.999881277590374 0.125 0.0031597235312519 0.526509670875206 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.294384339250003 0.00653526389697788 2.29204336611244 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.513C>T lpqB_c.513C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.6329128986197 0.189104318453829 214.057761575796 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.516C>G lpqB_c.516C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.516C>T lpqB_c.516C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.908144446427509 0.0153974005043644 17.4461131425891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.519C>T lpqB_c.519C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.522C>A lpqB_c.522C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.534C>G lpqB_c.534C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.549G>A lpqB_c.549G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.549G>T lpqB_c.549G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.555C>T lpqB_c.555C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.558C>T lpqB_c.558C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 2 16808 30530 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999934494956111 0.999763393503742 0.99999206693684 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.8163969538315 0.131636449523742 25.0652602654423 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 2 11500 23705 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999915636731767 0.999695284447545 0.999989783053538 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06130434782608 0.149383229063395 28.4413197127326 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.561G>T lpqB_c.561G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 35 401 16775 30131 0.00208209399167162 0.00145067008444318 0.00289451049645224 0.98686623870038 0.985525478315028 0.988113138258313 0.0802752293577981 0.0565497318096756 0.109876419403881 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.156774234309903 0.107610534888515 0.221858917793557 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 33 368 11469 23339 0.00286906624934793 0.00197573107651826 0.0040268977332274 0.984477158645126 0.98282168676063 0.986012253478973 0.0822942643391521 0.0573233032109095 0.113631557981714 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 0 0.18248316823801 0.123637849431244 0.261105381986235 NA NA NA NA NA NA 23 5) Not assoc w R Now listed Silent mutation no 0 +Rifampicin lpqB c.567C>T lpqB_c.567C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.57G>T lpqB_c.57G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.585C>G lpqB_c.585C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.588G>A lpqB_c.588G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 21 0 16789 30532 0.00124925639500297 0.000773470498752546 0.00190899053306069 1 0.999879187193184 1 1 0.83890238478092 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 9.46741729237089 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 13 0 11489 23707 0.00113023821944009 0.000601937155487611 0.00193196626494298 1 0.999844409142079 1 1 0.752947361999529 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 6.28688570681876 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.597C>T lpqB_c.597C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.600C>G lpqB_c.600C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.75142405620251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.12235036001139 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.603A>G lpqB_c.603A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.618A>G lpqB_c.618A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.621C>T lpqB_c.621C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.633G>T lpqB_c.633G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.642G>T lpqB_c.642G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.654C>T lpqB_c.654C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 4 16807 30528 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999868989912223 0.999664596427238 0.999964303043777 0.428571428571428 0.0989882784425078 0.815948432359917 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.36228952222288 0.19952864446048 8.05486976701789 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.657T>C lpqB_c.657T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.670C>T lpqB_c.670C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.675C>A lpqB_c.675C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.684G>A lpqB_c.684G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.693C>G lpqB_c.693C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.693C>T lpqB_c.693C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.6G>C lpqB_c.6G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.705G>A lpqB_c.705G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.720C>T lpqB_c.720C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.729C>A lpqB_c.729C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.729C>G lpqB_c.729C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.9820231071276 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.729C>T lpqB_c.729C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.6329128986197 0.189104318453829 214.057761575796 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.72C>G lpqB_c.72C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.738A>C lpqB_c.738A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.744C>T lpqB_c.744C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.75G>A lpqB_c.75G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.9820231071276 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.24912710990902 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.75G>C lpqB_c.75G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.765C>A lpqB_c.765C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.777C>T lpqB_c.777C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.789T>A lpqB_c.789T>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.804C>T lpqB_c.804C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.810C>T lpqB_c.810C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.816C>T lpqB_c.816C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.81C>T lpqB_c.81C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.822C>A lpqB_c.822C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.825C>T lpqB_c.825C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.828C>T lpqB_c.828C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.831G>A lpqB_c.831G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.834G>A lpqB_c.834G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.843G>T lpqB_c.843G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.849C>T lpqB_c.849C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.852C>T lpqB_c.852C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.858C>T lpqB_c.858C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.879T>C lpqB_c.879T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.894C>T lpqB_c.894C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.897T>C lpqB_c.897T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.900C>A lpqB_c.900C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.900C>G lpqB_c.900C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.750576632084797 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.903T>C lpqB_c.903T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.909G>A lpqB_c.909G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.909G>C lpqB_c.909G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.915C>G lpqB_c.915C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.921G>A lpqB_c.921G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.921G>C lpqB_c.921G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 12 16808 30520 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999606969736669 0.999313555980458 0.999796899563454 0.142857142857142 0.0177945154831915 0.428129160909698 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.302633666508012 0.032889580275051 1.35967332152622 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 8 11500 23699 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999662546927068 0.999335191784523 0.999854300817065 0.2 0.0252107263268333 0.556095462307641 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.515195652173913 0.0532924302528778 2.58225829949872 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.924G>T lpqB_c.924G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.936T>C lpqB_c.936T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.939C>A lpqB_c.939C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.945G>T lpqB_c.945G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.951G>A lpqB_c.951G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.957C>T lpqB_c.957C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.6329128986197 0.189104318453829 214.057761575796 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.960G>A lpqB_c.960G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.966C>T lpqB_c.966C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.969A>G lpqB_c.969A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.972A>G lpqB_c.972A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.981G>T lpqB_c.981G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.990A>C lpqB_c.990A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.999C>A lpqB_c.999C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.999C>T lpqB_c.999C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 5 1 16805 30531 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 0.999967247478055 0.999817528289014 0.999999170778282 0.833333333333333 0.358765421002325 0.99578925548551 NA NA NA NA NA NA NA NA NA NA NA NA False False 9.08390360011901 1.01631102884943 428.726615606949 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB c.99T>C lpqB_c.99T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin lpqB LoF lpqB_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Ala187Thr lpqB_p.Ala187Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3257 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Ala187Val lpqB_p.Ala187Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Ala204Val lpqB_p.Ala204Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3187 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Ala211Gly lpqB_p.Ala211Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Ala24Thr lpqB_p.Ala24Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Ala264Gly lpqB_p.Ala264Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Ala274Val lpqB_p.Ala274Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Ala287Val lpqB_p.Ala287Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Ala294Val lpqB_p.Ala294Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Ala303Val lpqB_p.Ala303Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 9.67028206568003 0.541992006917746 476.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 10.9713274274722 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Ala314Ser lpqB_p.Ala314Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 12 8 16798 30524 0.000713860797144556 0.000368914962606047 0.00124663876852724 0.999737979824446 0.999483781433772 0.999886871715824 0.6 0.360542587307489 0.808809939274692 NA NA NA 0 0 0.369416647552819 NA NA NA NA 3194 4649 False False 2.72568162876532 1.02430321026523 7.68890030080649 0 0 0.000219578190293692 0.999737979824446 0.999483781433772 0.999886871715824 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 7 6 11495 23701 0.000608589810467744 0.000244718560881119 0.00125352303681455 0.9997469101953 0.999449212060655 0.99990711502044 0.538461538461538 0.251345482270303 0.807767558198712 0 0 0.841886116991581 0 0 0.4592581264399 0 0 10.9766099824589 1 504 3890 False False 0 0 0 0 0 0 0 2.40549514281571 0.692028881085274 8.66552232847307 0 0 0.000320860166613556 0.9997469101953 0.999449212060655 0.99990711502044 2 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Ala327Gly lpqB_p.Ala327Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3184 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2642 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Ala327Val lpqB_p.Ala327Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Ala368Thr lpqB_p.Ala368Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Ala373Glu lpqB_p.Ala373Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3192 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Ala373Ser lpqB_p.Ala373Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3219 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2672 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Ala384Ser lpqB_p.Ala384Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 23 0 23 0 26 16810 30506 0 0 0.000219421459229958 0.999148434429451 0.998752506314373 0.99944365605196 0 0 0.132274604497754 0 0 0.148185128915224 0 0 0.132274604497754 0 0 0.315740225662429 7.6413301685907e-05 49 4649 True False 0 0 0.276689956335831 0 0 0.000219421459229958 0.999148434429451 0.998752506314373 0.99944365605196 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 19 0 19 0 22 11502 23685 0 0 0.000320664925697395 0.999072004049436 0.998595338091004 0.999418341378366 0 0 0.154372512815574 0 0 0.176466911806965 0 0 0.154372512815574 0 0 0.441361783040119 0.000842429864576289 44 3890 False False 0 0 0 0 0 0 0 0 0 0.375993398548359 0 0 0.000320664925697395 0.999072004049436 0.998595338091004 0.999418341378366 2 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Ala388Val lpqB_p.Ala388Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 70.7538526941519 1 1627.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 80.2773259044493 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Ala416Thr lpqB_p.Ala416Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3246 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2698 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Ala416Val lpqB_p.Ala416Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Ala434Val lpqB_p.Ala434Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.75142405620251 0.304356294847217 327.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12235036001139 0.310791984491028 261 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Ala456Val lpqB_p.Ala456Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 13 0 13 8 17 16802 30515 0.000475907198096371 0.00020548462525215 0.000937510381255989 0.999443207126948 0.999108669858669 0.999675615241488 0.32 0.149495422613569 0.535000717497372 0 0 0.24705263800047 0 0 0.195064322969093 0 0 0.596010886847512 0.00617847816813644 96 4649 False False 0.85466015950482 0.31916304128729 2.09015219153435 0 0 0.000219525921733526 0.999443207126948 0.999108669858669 0.999675615241488 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 12 0 12 4 16 11498 23691 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 0.999325093854136 0.99890422546949 0.999614185177149 0.2 0.0573339970500327 0.436614002996668 0 0 0.264648469397051 0 0 0.205907214207822 0 0 0.741692762696411 0.011971065118716 86 3890 False False 0 0 0 0 0 0 0 0.515111323708471 0.125291085399331 1.59728998694425 0 0 0.000320776462830572 0.999325093854136 0.99890422546949 0.999614185177149 6 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Ala510Thr lpqB_p.Ala510Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 4.3952647534881 0.556931257223419 920.5 4649 False False 0 0 1.9820231071276 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 4.98782730104768 0.555669461962421 375.5 3890 False False 0 0 0 0 0 0 0 0 0 2.24912710990902 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Ala537Val lpqB_p.Ala537Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Ala539Val lpqB_p.Ala539Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3204 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2658 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Ala540Ser lpqB_p.Ala540Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3237 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2690 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Ala548Ser lpqB_p.Ala548Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Ala548Thr lpqB_p.Ala548Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 2 16808 30530 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999934494956111 0.999763393503742 0.99999206693684 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 70.7645776857468 1 1627.5 4649 False False 1.8163969538315 0.131636449523742 25.0652602654423 0 0 0.000219447565534303 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 2653 3890 False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 0 0 0.000320720684566658 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Ala58Ser lpqB_p.Ala58Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 70.7668929171829 1 1627.5 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 0 0 0.000219447565534303 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2674 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Ala63Val lpqB_p.Ala63Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Ala68Ser lpqB_p.Ala68Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Ala77Val lpqB_p.Ala77Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3243 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Ala84Gly lpqB_p.Ala84Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 41 1 40 28 40 16782 30492 0.00166567519333729 0.00110710558710172 0.00240647153309903 0.998689899122232 0.9982164372121 0.999063884888636 0.411764705882352 0.29373508869412 0.537732739663549 0.024390243902439 0.000617316893286519 0.128554020384146 0.024390243902439 0.000617316893286519 0.128554020384146 0.0454236682159456 0.00112658627701184 0.268094015376341 5.55136712096856e-07 31 4649 True False 1.27186271004647 0.755364530301402 2.11441698421669 5.95841029613299e-05 1.5085377398469e-06 0.000331936161589525 0.998689899122232 0.9982164372121 0.999063884888636 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 35 1 34 21 34 11481 23673 0.00182576943140323 0.00113052422891288 0.00278953561568501 0.998565824440038 0.997996454606338 0.999006593594267 0.381818181818181 0.254091648322545 0.522737745039497 0.0285714285714285 0.000723104376338095 0.149172079656431 0.0285714285714285 0.000723104376338095 0.149172079656431 0.0606449530426228 0.00149614606743932 0.361607206696468 3.20167451858156e-05 32 3890 True False 0 0 0 0 0 0 0 1.27354401389507 0.702044253723636 2.25942515842472 8.70928409684723e-05 2.20499739343575e-06 0.000485153659811675 0.998565824440038 0.997996454606338 0.999006593594267 4 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Arg145Cys lpqB_p.Arg145Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Arg207His lpqB_p.Arg207His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Arg215Cys lpqB_p.Arg215Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3214 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2667 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Arg240Cys lpqB_p.Arg240Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 7 16810 30525 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 0 0 0.409616397225003 0 0 0.521823750104981 0 0 0.409616397225003 0 0 1.98189325920797 0.168444418238817 233.5 4649 False False 0 0 1.26007067420399 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 3.12221861743114 0.310788655266302 237.5 3890 False False 0 0 0 0 0 0 0 0 0 2.24912710990902 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Arg240Leu lpqB_p.Arg240Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Arg260Lys lpqB_p.Arg260Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3258 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2708 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Arg2Trp lpqB_p.Arg2Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Arg332Pro lpqB_p.Arg332Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3247 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2699 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Arg342Gln lpqB_p.Arg342Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3215 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2668 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Arg356Cys lpqB_p.Arg356Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Arg366His lpqB_p.Arg366His 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Arg498Leu lpqB_p.Arg498Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.75142405620251 0.304356294847217 327.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12235036001139 0.310791984491028 261 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Arg507His lpqB_p.Arg507His 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Arg529His lpqB_p.Arg529His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3259 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 2709 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Arg53His lpqB_p.Arg53His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3226 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2680 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Asn167Lys lpqB_p.Asn167Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 80.2910622977969 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Asn167Ser lpqB_p.Asn167Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Asn322Lys lpqB_p.Asn322Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3227 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Asn541Ser lpqB_p.Asn541Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3263 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2712 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Asp142Asn lpqB_p.Asp142Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.9820231071276 0.168448731581911 252 4649 False False 0 0 1.9820231071276 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 2.24912710990902 0.180424970179968 177 3890 False False 0 0 0 0 0 0 0 0 0 2.24912710990902 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Asp142Gly lpqB_p.Asp142Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 554 4026 16256 26506 0.0329565734681737 0.030309169551642 0.0357671301490315 0.868138346652692 0.86429182270075 0.871914679165189 0.120960698689956 0.111651703822687 0.130755906496867 NA NA NA 0 0 0.000915844504759959 NA NA NA NA 3240 4649 False True 0.224370883059326 0.204501975740936 0.245808038987743 0 0 0.000226898433673774 0.868138346652692 0.86429182270075 0.871914679165189 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 403 3284 11099 20423 0.035037384802643 0.031751712295794 0.0385610171469412 0.861475513561395 0.85701272377602 0.865849485749833 0.109302956333062 0.0994085334889271 0.119821409704757 NA NA NA 0 0 0.00112265785374778 NA NA NA NA 2693 3890 False True 0 1 1 0 0 0 0 0.225807095019807 0.202570738661086 0.251202197067685 0 0 0.00033230619888345 0.861475513561395 0.85701272377602 0.865849485749833 449 5) Not assoc w R New NotAwR yes 5 +Rifampicin lpqB p.Asp156Ala lpqB_p.Asp156Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 3195 4649 False False 0 0 1.9820231071276 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 2649 3890 False False 0 0 0 0 0 0 0 0 0 2.24912710990902 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Asp190Asn lpqB_p.Asp190Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 14 0 14 9 14 16801 30518 0.000535395597858417 0.000244845253515427 0.00101610321951737 0.999541464692781 0.999230775228684 0.999749292529582 0.391304347826087 0.197076423969014 0.61458104261115 0 0 0.231635761650116 0 0 0.231635761650116 0 0 0.54770503189725 0.0034205998357507 84 4649 False False 1.16771110563146 0.445740845122765 2.89697058370655 0 0 0.000219538986540545 0.999541464692781 0.999230775228684 0.999749292529582 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 14 0 14 9 14 11493 23693 0.000782472613458529 0.000357856744032263 0.00148485474620048 0.999409457122369 0.999009367705732 0.999677108302285 0.391304347826087 0.197076423969014 0.61458104261115 0 0 0.231635761650116 0 0 0.231635761650116 0 0 0.621630408073805 0.0073408921911038 74 3890 False False 0 0 0 0 0 0 0 1.32526009620762 0.505838504430309 3.28828972217945 0 0 0.000320915993408392 0.999409457122369 0.999009367705732 0.999677108302285 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Asp306Glu lpqB_p.Asp306Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Asp311Glu lpqB_p.Asp311Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 7 16810 30525 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 1.54246355322091 0.0957757853990922 188.5 4649 False False 0 0 1.26007067420399 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 3.12221861743114 0.310788655266302 237.5 3890 False False 0 0 0 0 0 0 0 0 0 2.24912710990902 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 3 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Asp370Glu lpqB_p.Asp370Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Asp370Gly lpqB_p.Asp370Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3200 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2655 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Asp401Ala lpqB_p.Asp401Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Asp501Asn lpqB_p.Asp501Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3205 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2659 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Asp501Gly lpqB_p.Asp501Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3249 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2701 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Asp509Asn lpqB_p.Asp509Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3201 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2656 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Asp509Gly lpqB_p.Asp509Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Asp525His lpqB_p.Asp525His 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.75142405620251 0.304356294847217 327.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Asp568Glu lpqB_p.Asp568Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3230 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2683 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Asp61Asn lpqB_p.Asp61Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3188 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2644 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Gln128His lpqB_p.Gln128His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3253 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2704 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Gln193Pro lpqB_p.Gln193Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3238 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2691 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Gln357Leu lpqB_p.Gln357Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 5 16809 30527 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999836237390279 0.999617874429585 0.999946824656822 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.841886116991581 0 0 0.521823750104981 0 0 9.67022395468835 0.541991207287615 463 4649 False False 0.363222083407698 0.00768325476784986 3.24674897733262 0 0 0.000219434511605659 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 5 11501 23702 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999789091829417 0.999507879904061 0.999931515258336 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.841886116991581 0 0 0.521823750104981 0 0 10.9713556379464 1 1214.5 3890 False False 0 0 0 0 0 0 0 0.412172854534388 0.00871781959321125 3.68423590106777 0 0 0.000320692802708327 0.999789091829417 0.999507879904061 0.999931515258336 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Gln386Glu lpqB_p.Gln386Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Gln424Lys lpqB_p.Gln424Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Gln551Pro lpqB_p.Gln551Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3244 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2696 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Glu102Asp lpqB_p.Glu102Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3248 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2700 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Glu123Lys lpqB_p.Glu123Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3206 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2660 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Glu250Ala lpqB_p.Glu250Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 11 1 16799 30531 0.00065437239738251 0.000326704163498642 0.00117055062018267 0.999967247478055 0.999817528289014 0.999999170778282 0.916666666666666 0.615203834849055 0.997892406768139 0 0 0.975 0 0 0.975 0 0 70.8047640652255 1 938.5 4649 False False 19.9917256979582 2.90506952047996 857.005572217769 0 0 0.000219565120820351 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 11 1 11491 23706 0.000956355416449313 0.000477502787107626 0.00171053820723243 0.999957818365883 0.999765001636458 0.999998932054057 0.916666666666666 0.615203834849055 0.997892406768139 0 0 0.975 0 0 0.975 0 0 80.3608475608456 1 1214.5 3890 False False 0 0 0 0 0 0 0 22.6930641371508 3.29729020870041 972.205014864432 0 0 0.000320971839633333 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Glu295Ala lpqB_p.Glu295Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Glu32Ala lpqB_p.Glu32Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3260 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2710 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Glu345Lys lpqB_p.Glu345Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Glu469Gln lpqB_p.Glu469Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 0 8 16810 30524 0 0 0.000219421459229958 0.999737979824446 0.999483781433772 0.999886871715824 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 1.06393155676265 0.057171463062894 176 4649 False False 0 0 1.06393155676265 0 0 0.000219421459229958 0.999737979824446 0.999483781433772 0.999886871715824 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 0 8 11502 23699 0 0 0.000320664925697395 0.999662546927068 0.999335191784523 0.999854300817065 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 1.20731769892417 0.0599154010311281 117.5 3890 False False 0 0 0 0 0 0 0 0 0 1.20731769892417 0 0 0.000320664925697395 0.999662546927068 0.999335191784523 0.999854300817065 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Glu54Asp lpqB_p.Glu54Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 9.67028206568003 0.541992006917746 476.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 10.9713274274722 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Gly10Ser lpqB_p.Gly10Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Gly127Val lpqB_p.Gly127Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Gly143Asp lpqB_p.Gly143Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3245 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2697 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Gly143Cys lpqB_p.Gly143Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Gly152Glu lpqB_p.Gly152Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 7 16810 30525 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 0 0 0.409616397225003 0 0 0.841886116991581 0 0 0.409616397225003 0 0 9.66901713151938 0.541974614798428 449 4649 False False 0 0 1.26007067420399 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 7 11502 23700 0 0 0.000320664925697395 0.999704728561184 0.999391723222185 0.999881277590374 0 0 0.409616397225003 0 0 0.841886116991581 0 0 0.409616397225003 0 0 10.9694794681607 1 504 3890 False False 0 0 0 0 0 0 0 0 0 1.42986888806462 0 0 0.000320664925697395 0.999704728561184 0.999391723222185 0.999881277590374 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Gly226Glu lpqB_p.Gly226Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Gly241Glu lpqB_p.Gly241Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3207 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2661 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Gly243Ala lpqB_p.Gly243Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3228 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2681 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Gly278Ala lpqB_p.Gly278Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Gly278Glu lpqB_p.Gly278Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 9.66996583219897 0.541987658825864 457.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 10.9708654377183 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Gly296Val lpqB_p.Gly296Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Gly29Arg lpqB_p.Gly29Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3220 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2673 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Gly338Trp lpqB_p.Gly338Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3264 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Gly381Ser lpqB_p.Gly381Ser 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 3 16808 30529 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999901742434167 0.999712876815577 0.99997973646933 0.4 0.0527449505263169 0.853367200365326 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3193 4649 False False 1.21089163890211 0.101157890363798 10.5697741171107 0 0 0.000219447565534303 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2648 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Gly382dup lpqB_p.Gly382dup 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Gly382Ser lpqB_p.Gly382Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Gly423Arg lpqB_p.Gly423Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3199 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2654 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Gly45Ser lpqB_p.Gly45Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Gly45Val lpqB_p.Gly45Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Gly461Ala lpqB_p.Gly461Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.75142405620251 0.304356294847217 327.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12235036001139 0.310791984491028 261 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Gly530Glu lpqB_p.Gly530Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3265 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2713 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Gly549Asp lpqB_p.Gly549Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3211 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2665 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Gly549Cys lpqB_p.Gly549Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3209 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2663 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Gly549Ser lpqB_p.Gly549Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Gly565Ser lpqB_p.Gly565Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Gly576Arg lpqB_p.Gly576Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3254 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2705 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Gly576Thr lpqB_p.Gly576Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3234 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2687 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Gly583* lpqB_p.Gly583* 2 stop_gained (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.His258Arg lpqB_p.His258Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.His391Arg lpqB_p.His391Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3261 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2711 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.His391Tyr lpqB_p.His391Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3250 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.His92Arg lpqB_p.His92Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3218 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2671 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.His92Tyr lpqB_p.His92Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3196 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2650 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Ile112Thr lpqB_p.Ile112Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3208 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2662 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Ile238Thr lpqB_p.Ile238Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Ile282Val lpqB_p.Ile282Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Ile5Ser lpqB_p.Ile5Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 9.67028206568003 0.541992006917746 476.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 10.9713274274722 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Leu137Val lpqB_p.Leu137Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Leu13Val lpqB_p.Leu13Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Leu364Pro lpqB_p.Leu364Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.67117271135833 0.542004252564565 721 4649 False False 0.908144446427509 0.0153974005043644 17.4461131425891 0 0 0.000219434511605659 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Leu380Phe lpqB_p.Leu380Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Leu400Val lpqB_p.Leu400Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Leu446Phe lpqB_p.Leu446Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Leu51Val lpqB_p.Leu51Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Leu52Ser lpqB_p.Leu52Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Leu535Val lpqB_p.Leu535Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3197 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2651 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Leu581Val lpqB_p.Leu581Val 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 6 16809 30526 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999803484868334 0.999572318737888 0.999927879105266 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA 0 0 0.4592581264399 NA NA NA NA 3189 4649 False False 0.302675154183274 0.00658396461982027 2.49513982006856 0 0 0.000219434511605659 0.999803484868334 0.999572318737888 0.999927879105266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 3 11501 23704 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.99987345509765 0.999630227076139 0.999973902638554 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2645 3890 False False 0 0 0 0 0 0 0 0.687012723531287 0.0130900577164196 8.55773267307823 0 0 0.000320692802708327 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Lys139Glu lpqB_p.Lys139Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3216 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2669 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Lys165Thr lpqB_p.Lys165Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3185 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2643 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Lys251Asn lpqB_p.Lys251Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3235 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2688 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Met108Thr lpqB_p.Met108Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2714 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Met343Ile lpqB_p.Met343Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3266 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2715 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Met343Thr lpqB_p.Met343Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3217 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2670 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Met457Val lpqB_p.Met457Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3202 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2657 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Phe55Leu lpqB_p.Phe55Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 5 9 16805 30523 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 0.999705227302502 0.999440503684993 0.999865202576615 0.357142857142857 0.127598429859159 0.648619889384008 0 0 0.4592581264399 0 0 0.336267116879942 0 0 1.54282142423847 0.0957950128376074 209.5 4649 False False 1.00905815068266 0.265595742451005 3.35339436934209 0 0 0.000219486736640675 0.999705227302502 0.999440503684993 0.999865202576615 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 5 7 11497 23700 0.00043470700747696 0.000141162766530747 0.00101416710312943 0.999704728561184 0.999391723222185 0.999881277590374 0.416666666666666 0.15165222980843 0.723330314317894 0 0 0.521823750104981 0 0 0.409616397225003 0 0 2.24991671943314 0.180468018769617 198 3890 False False 0 0 0 0 0 0 0 1.47243380260689 0.368413517907112 5.39047319662763 0 0 0.000320804359238686 0.999704728561184 0.999391723222185 0.999881277590374 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Phe72Leu lpqB_p.Phe72Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3231 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2684 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Phe8Leu lpqB_p.Phe8Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 3 16809 30529 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999901742434167 0.999712876815577 0.99997973646933 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3241 4649 False False 0.605409800305391 0.0115361654751757 7.54087213596152 0 0 0.000219434511605659 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2694 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Pro132Ser lpqB_p.Pro132Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3229 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2682 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Pro134Leu lpqB_p.Pro134Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Pro150Thr lpqB_p.Pro150Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Pro181Ser lpqB_p.Pro181Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Pro208Leu lpqB_p.Pro208Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3212 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Pro208Ser lpqB_p.Pro208Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Pro257Arg lpqB_p.Pro257Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3213 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2666 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Pro257Ser lpqB_p.Pro257Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3236 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2689 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Pro279Ser lpqB_p.Pro279Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3251 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2702 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Pro279Thr lpqB_p.Pro279Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3267 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2716 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Pro335Leu lpqB_p.Pro335Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Pro335Ser lpqB_p.Pro335Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Pro337His lpqB_p.Pro337His 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 1 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Pro34Gln lpqB_p.Pro34Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 9 1 8 2 8 16808 30524 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999737979824446 0.999483781433772 0.999886871715824 0.2 0.0252107263268333 0.556095462307641 0.111111111111111 0.00280913674659921 0.482496514917337 0.111111111111111 0.00280913674659921 0.482496514917337 0.22700499762018 0.00511962663506671 1.69351736734399 0.17227413977332 284 4649 False False 0.454009995240361 0.0469649977420217 2.27541152741616 5.94919388422868e-05 1.50620434989522e-06 0.000331422795737767 0.999737979824446 0.999483781433772 0.999886871715824 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 3 11501 23704 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.99987345509765 0.999630227076139 0.999973902638554 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98868218084989 0.555670981350655 466 3890 False False 0 0 0 0 0 0 0 0.687012723531287 0.0130900577164196 8.55773267307823 0 0 0.000320692802708327 0.99987345509765 0.999630227076139 0.999973902638554 1 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Pro34Ser lpqB_p.Pro34Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Pro420Leu lpqB_p.Pro420Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 25 16809 30507 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999181186951395 0.998791506081474 0.999470039476732 0.0384615384615384 0.00097328789333503 0.196369646762539 NA NA NA 0 0 0.137185171530712 NA NA NA NA 3255 4649 False False 0.0725968231304658 0.00177224844421437 0.443553154597488 0 0 0.000219434511605659 0.999181186951395 0.998791506081474 0.999470039476732 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 23 11501 23684 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.99902982241532 0.998544610722761 0.99938489435488 0.0416666666666666 0.00105435244546974 0.211201683456973 NA NA NA 0 0 0.148185128915224 NA NA NA NA 2706 3890 False False 0 0 0 0 0 0 0 0.0895347474510723 0.00217743413029611 0.551561418572831 0 0 0.000320692802708327 0.99902982241532 0.998544610722761 0.99938489435488 1 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Pro440Gln lpqB_p.Pro440Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Pro440Ser lpqB_p.Pro440Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Pro527Ala lpqB_p.Pro527Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 8 0 16802 30532 0.000475907198096371 0.00020548462525215 0.000937510381255989 1 0.999879187193184 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 3186 4649 False False Inf 3.10133467016734 Inf 0 0 0.000219525921733526 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Pro527Ser lpqB_p.Pro527Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Pro534Ala lpqB_p.Pro534Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Pro542Ala lpqB_p.Pro542Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Pro550Leu lpqB_p.Pro550Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 80.2910622977969 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Pro550Ser lpqB_p.Pro550Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Pro564Leu lpqB_p.Pro564Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Pro570Gln lpqB_p.Pro570Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3224 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2678 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Pro570Ser lpqB_p.Pro570Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3221 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2675 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Pro575Gln lpqB_p.Pro575Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.9820231071276 0.168448731581911 252 4649 False False 0 0 1.9820231071276 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Pro579Ala lpqB_p.Pro579Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3225 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2679 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Ser117Leu lpqB_p.Ser117Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 8 16808 30524 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999737979824446 0.999483781433772 0.999886871715824 0.2 0.0252107263268333 0.556095462307641 NA NA NA 0 0 0.369416647552819 NA NA NA NA 3232 4649 False False 0.454009995240361 0.0469649977420217 2.27541152741616 0 0 0.000219447565534303 0.999737979824446 0.999483781433772 0.999886871715824 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 8 11500 23699 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999662546927068 0.999335191784523 0.999854300817065 0.2 0.0252107263268333 0.556095462307641 NA NA NA 0 0 0.369416647552819 NA NA NA NA 2685 3890 False False 0 0 0 0 0 0 0 0.515195652173913 0.0532924302528778 2.58225829949872 0 0 0.000320720684566658 0.999662546927068 0.999335191784523 0.999854300817065 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Ser18Gly lpqB_p.Ser18Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Ser21Arg lpqB_p.Ser21Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 70.7538526941519 1 1627.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 2 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Ser394Leu lpqB_p.Ser394Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 6 220 16804 30312 0.000356930398572278 0.000130998068917797 0.000776724091447791 0.992794445172278 0.991780941085467 0.993712405248836 0.0265486725663716 0.00980387951913531 0.0568867092427435 NA NA NA 0 0 0.0166278395399936 NA NA NA NA 3252 4649 False True 0.0491960788556837 0.0178763503978317 0.108850347246986 0 0 0.000219499796783869 0.992794445172278 0.991780941085467 0.993712405248836 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 5 206 11497 23501 0.00043470700747696 0.000141162766530747 0.00101416710312943 0.991310583371999 0.990045829361759 0.99245256745733 0.0236966824644549 0.00773800968627835 0.0544308246345451 NA NA NA 0 0 0.0177478010074704 NA NA NA NA 2703 3890 False True 1 1 1 0 0 0 0 0.0496140403026201 0.0159562023036093 0.117720004488087 0 0 0.000320804359238686 0.991310583371999 0.990045829361759 0.99245256745733 12 5) Not assoc w R New NotAwR yes 5 +Rifampicin lpqB p.Ser437Ile lpqB_p.Ser437Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3222 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2676 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Ser491Leu lpqB_p.Ser491Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3268 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Ser557Leu lpqB_p.Ser557Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.81634838479386 0.0231376410853604 142.42572627634 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Ser562Arg lpqB_p.Ser562Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Ser76Leu lpqB_p.Ser76Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0465715996825058 Inf 0.355075831185839 416 4649 False False Inf 0.0465715996825058 Inf 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0528490600080728 Inf 0.32667783805277 340.5 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Thr140Lys lpqB_p.Thr140Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3190 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2646 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Thr140Met lpqB_p.Thr140Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Thr163Met lpqB_p.Thr163Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Thr175Ala lpqB_p.Thr175Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3223 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2677 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Thr299Ile lpqB_p.Thr299Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Thr347Met lpqB_p.Thr347Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3262 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Thr433Ile lpqB_p.Thr433Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Thr433Ser lpqB_p.Thr433Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Thr479Asn lpqB_p.Thr479Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Thr479Ser lpqB_p.Thr479Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 10 0 10 0 11 16810 30521 0 0 0.000219421459229958 0.999639722258614 0.999355455254591 0.999820137367966 0 0 0.284914152918154 0 0 0.30849710781876 0 0 0.284914152918154 0 0 0.810136286654261 0.0177759878309813 117.5 4649 False False 0 0 0.723522114724776 0 0 0.000219421459229958 0.999639722258614 0.999355455254591 0.999820137367966 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 0 9 11502 23698 0 0 0.000320664925697395 0.999620365292951 0.999279457952852 0.99982639261309 0 0 0.336267116879942 0 0 0.369416647552819 0 0 0.336267116879942 0 0 1.20726675935225 0.0599133727630747 114.5 3890 False False 0 0 0 0 0 0 0 0 0 1.04405446176545 0 0 0.000320664925697395 0.999620365292951 0.999279457952852 0.99982639261309 2 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Thr4Ala lpqB_p.Thr4Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3239 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2692 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Thr506Ile lpqB_p.Thr506Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3242 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2695 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Thr508Ser lpqB_p.Thr508Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Thr536Ala lpqB_p.Thr536Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Thr536Met lpqB_p.Thr536Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Val104Ala lpqB_p.Val104Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3191 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2647 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Val106Met lpqB_p.Val106Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3203 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Val119Met lpqB_p.Val119Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Val121Ala lpqB_p.Val121Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Val153Ile lpqB_p.Val153Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Val180Ala lpqB_p.Val180Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3233 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2686 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Val228Met lpqB_p.Val228Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0465715996825058 Inf 0.355075831185839 416 4649 False False Inf 0.0465715996825058 Inf 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Val247Leu lpqB_p.Val247Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3210 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2664 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Val281Met lpqB_p.Val281Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Val302Ile lpqB_p.Val302Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Val31Ala lpqB_p.Val31Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Val31Ile lpqB_p.Val31Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Val321Met lpqB_p.Val321Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 5 2 16805 30530 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 0.999934494956111 0.999763393503742 0.99999206693684 0.714285714285714 0.290420863737342 0.963307433823914 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.67347104264285 0.542035853380699 756.5 4649 False False 4.54180303481106 0.743433860385311 47.6944906777554 0 0 0.000219486736640675 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Val326Ala lpqB_p.Val326Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Val326Met lpqB_p.Val326Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Val336Ala lpqB_p.Val336Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Val385Leu lpqB_p.Val385Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Val413Ala lpqB_p.Val413Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Val468Ile lpqB_p.Val468Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Val492Ala lpqB_p.Val492Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 5 0 16805 30532 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 1 0.999879187193184 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 3198 4649 False False Inf 1.66460481015123 Inf 0 0 0.000219486736640675 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2652 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 2 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Val493Met lpqB_p.Val493Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Val547Ala lpqB_p.Val547Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Val547Ile lpqB_p.Val547Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Val560Ile lpqB_p.Val560Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 3 4 16807 30528 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999868989912223 0.999664596427238 0.999964303043777 0.428571428571428 0.0989882784425078 0.815948432359917 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.75191523168538 0.304360274269881 360.5 4649 False False 1.36228952222288 0.19952864446048 8.05486976701789 0 0 0.000219460621016169 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 2 4 11500 23703 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999831273463534 0.999568049920357 0.99995402584539 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12289352368013 0.310805712195535 291 3890 False False 0 0 0 0 0 0 0 1.0305652173913 0.0931903474189042 7.19201282268065 0 0 0.000320720684566658 0.999831273463534 0.999568049920357 0.99995402584539 2 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Val574Ala lpqB_p.Val574Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin lpqB p.Val96Ala lpqB_p.Val96Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3256 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2707 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-106A>G mtrA_c.-106A>G 2 upstream_gene_variant 3627455 NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3917 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3287 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.108C>T mtrA_c.108C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.-108C>T mtrA_c.-108C>T 2 upstream_gene_variant 3627457 1 4 0 4 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 2.75133392880791 0.304355565478378 305.5 4649 False False 0 0 1.9820231071276 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 4.98803779447094 0.555669835711629 381 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-111C>G mtrA_c.-111C>G 2 upstream_gene_variant 3627460 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.111C>T mtrA_c.111C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.-112C>A mtrA_c.-112C>A 2 upstream_gene_variant 3627461 1 0 0 0 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3920 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3290 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-114G>A mtrA_c.-114G>A 2 upstream_gene_variant 3627463 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-114G>C mtrA_c.-114G>C 2 upstream_gene_variant 3627463 NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3926 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3295 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 10 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-121T>C mtrA_c.-121T>C 2 upstream_gene_variant 3627470 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-123G>A mtrA_c.-123G>A 2 upstream_gene_variant 3627472 NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3902 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3275 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.123T>C mtrA_c.123T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.9820231071276 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.24912710990902 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.124C>T mtrA_c.124C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.126G>A mtrA_c.126G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.126G>T mtrA_c.126G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.-128C>T mtrA_c.-128C>T 2 upstream_gene_variant 3627477 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.129C>T mtrA_c.129C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.-129G>C mtrA_c.-129G>C 2 upstream_gene_variant 3627478 NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3910 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3282 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-129G>T mtrA_c.-129G>T 2 upstream_gene_variant 3627478 1 13 1 12 2 12 16808 30520 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999606969736669 0.999313555980458 0.999796899563454 0.142857142857142 0.0177945154831915 0.428129160909698 0.0769230769230769 0.00194562849734675 0.360297435267877 0.0769230769230769 0.00194562849734675 0.360297435267877 0.151316833254006 0.00354361594392371 1.02286900354345 0.0411568800367915 136 4649 False False 0.302633666508012 0.032889580275051 1.35967332152622 5.94919388422868e-05 1.50620434989522e-06 0.000331422795737767 0.999606969736669 0.999313555980458 0.999796899563454 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 13 1 12 2 12 11500 23695 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999493820390602 0.999115973206486 0.999738423129043 0.142857142857142 0.0177945154831915 0.428129160909698 0.0769230769230769 0.00194562849734675 0.360297435267877 0.0769230769230769 0.00194562849734675 0.360297435267877 0.171702898550724 0.00402028181023372 1.16079159958497 0.0733825430681992 127 3890 False False 0 0 0 0 0 0 0 0.343405797101449 0.0373242917489932 1.54295916091394 8.69489609599165e-05 2.20135467503192e-06 0.000484352330576856 0.999493820390602 0.999115973206486 0.999738423129043 1 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.135G>A mtrA_c.135G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.-136T>G mtrA_c.-136T>G 2 upstream_gene_variant 3627485 1 5 0 5 1 5 16809 30527 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999836237390279 0.999617874429585 0.999946824656822 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.98214103142536 0.168452649138924 269 4649 False False 0.363222083407698 0.00768325476784986 3.24674897733262 0 0 0.000219434511605659 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 1 5 11501 23702 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999789091829417 0.999507879904061 0.999931515258336 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.521823750104981 0 0 0.521823750104981 0 0 2.24932299250856 0.180435646558949 191.5 3890 False False 0 0 0 0 0 0 0 0.412172854534388 0.00871781959321125 3.68423590106777 0 0 0.000320692802708327 0.999789091829417 0.999507879904061 0.999931515258336 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.138C>G mtrA_c.138C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.142C>T mtrA_c.142C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.-145G>A mtrA_c.-145G>A 2 upstream_gene_variant 3627494 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-146G>A mtrA_c.-146G>A 2 upstream_gene_variant 3627495 1 5 0 5 0 6 16810 30526 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 1.9819581831673 0.168446574692961 237.5 4649 False False 0 0 1.54251408011679 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 2.24912710990902 0.180424970179968 177 3890 False False 0 0 0 0 0 0 0 0 0 2.24912710990902 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-14G>A mtrA_c.-14G>A 2 upstream_gene_variant 3627363 1 0 0 0 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 3893 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 0 0 0.000219447565534303 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 3268 3890 False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 0 0 0.000320720684566658 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-14G>T mtrA_c.-14G>T 2 upstream_gene_variant 3627363 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-150G>T mtrA_c.-150G>T 2 upstream_gene_variant 3627499 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-153G>A mtrA_c.-153G>A 2 upstream_gene_variant 3627502 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-158G>C mtrA_c.-158G>C 2 upstream_gene_variant 3627507 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-159G>T mtrA_c.-159G>T 2 upstream_gene_variant 3627508 1 7 0 7 0 7 16810 30525 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 1.26007067420399 0.0561478031672613 154 4649 False False 0 0 1.26007067420399 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 7 11502 23700 0 0 0.000320664925697395 0.999704728561184 0.999391723222185 0.999881277590374 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 1.42986888806462 0.104255162462523 134.5 3890 False False 0 0 0 0 0 0 0 0 0 1.42986888806462 0 0 0.000320664925697395 0.999704728561184 0.999391723222185 0.999881277590374 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-15C>T mtrA_c.-15C>T 2 upstream_gene_variant 3627364 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.15G>A mtrA_c.15G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.160T>C mtrA_c.160T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.75142405620251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.12235036001139 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.162A>G mtrA_c.162A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.-162C>G mtrA_c.-162C>G 2 upstream_gene_variant 3627511 NA 0 0 0 82 93 16728 30439 0.0048780487804878 0.00388148113366835 0.006051378914965 0.99695401545919 0.996269742886194 0.997540814793275 0.468571428571428 0.392877228274623 0.545348229369903 NA NA NA 0 0 0.0388889985342758 NA NA NA NA 3924 4649 False True 1.60441703563145 1.17675494236286 2.18399131775165 0 0 0.000220496936026901 0.99695401545919 0.996269742886194 0.997540814793275 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 28 56 11474 23651 0.00243435924187097 0.00161820482579939 0.00351641960825614 0.997637828489475 0.996933605923382 0.998215162770186 0.333333333333333 0.234185310102691 0.444617973287304 NA NA NA 0 0 0.0637500966623622 NA NA NA NA 3293 3890 False True 0 1 1 0 0 0 0 1.03063447795014 0.629969379061208 1.65126658223547 0 0 0.000321447318471383 0.997637828489475 0.996933605923382 0.998215162770186 6 5) Not assoc w R New NotAwR yes 5 +Rifampicin mtrA c.163T>C mtrA_c.163T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.-166G>C mtrA_c.-166G>C 2 upstream_gene_variant 3627515 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-166G>T mtrA_c.-166G>T 2 upstream_gene_variant 3627515 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-173A>C mtrA_c.-173A>C 2 upstream_gene_variant 3627522 NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3899 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.175C>T mtrA_c.175C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.-178C>T mtrA_c.-178C>T 2 upstream_gene_variant 3627527 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.180C>T mtrA_c.180C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.-184G>A mtrA_c.-184G>A 2 upstream_gene_variant 3627533 1 1 0 1 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 0 0 0.975 0 0 0.521823750104981 0 0 70.7492227801408 1 1627.5 4649 False False 0 0 1.9820231071276 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 80.2739436376013 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-186G>T mtrA_c.-186G>T 2 upstream_gene_variant 3627535 1 2 0 2 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 9.67028206568003 0.541992006917746 476.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 10.9713274274722 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.189C>T mtrA_c.189C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.18A>G mtrA_c.18A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.-195C>T mtrA_c.-195C>T 2 upstream_gene_variant 3627544 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 3 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.204C>T mtrA_c.204C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.908144446427509 0.0153974005043644 17.4461131425891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.-204C>T mtrA_c.-204C>T 2 upstream_gene_variant 3627553 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.207G>A mtrA_c.207G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.-20delT mtrA_c.-20delT 2 upstream_gene_variant 3627368 1 21 0 21 4 21 16806 30511 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999312197039172 0.998948811248646 0.999574190302931 0.16 0.0453794523717095 0.360828454459272 0 0 0.161097615219079 0 0 0.161097615219079 0 0 0.348695011675504 0.000126301530284932 55 4649 True False 0.345806203000062 0.086319501498671 1.02513950961243 0 0 0.000219473678051534 0.999312197039172 0.998948811248646 0.999574190302931 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 15 0 15 2 15 11500 23692 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999367275488252 0.9989566315242 0.999645827023281 0.117647058823529 0.0145793168403025 0.36440916210125 0 0 0.218019360910534 0 0 0.218019360910534 0 0 0.574527216262029 0.00414253218149418 65 3890 False False 0 0 0 0 0 0 0 0.274689855072463 0.0304794343438515 1.18152047804442 0 0 0.000320720684566658 0.999367275488252 0.9989566315242 0.999645827023281 4 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-211C>A mtrA_c.-211C>A 2 upstream_gene_variant 3627560 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-211C>T mtrA_c.-211C>T 2 upstream_gene_variant 3627560 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.213G>A mtrA_c.213G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.-216C>T mtrA_c.-216C>T 2 upstream_gene_variant 3627565 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3918 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3288 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.21G>A mtrA_c.21G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.-231C>T mtrA_c.-231C>T 2 upstream_gene_variant 3627580 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.231T>G mtrA_c.231T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.-237C>T mtrA_c.-237C>T 2 upstream_gene_variant 3627586 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3890 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3265 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.240G>A mtrA_c.240G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.-245A>C mtrA_c.-245A>C 2 upstream_gene_variant 3627594 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-246G>A mtrA_c.-246G>A 2 upstream_gene_variant 3627595 1 6 0 6 16 7 16794 30525 0.000951814396192742 0.000544138942285324 0.00154522796648703 0.99977073234639 0.999527678427408 0.999907817703152 0.695652173913043 0.470808333991493 0.8678971203019 0 0 0.4592581264399 0 0 0.409616397225003 0 0 1.54393317052302 0.0958548583561012 212 4649 False False 4.15454499055785 1.61661452653012 11.9434638191734 0 0 0.000219630483749807 0.99977073234639 0.999527678427408 0.999907817703152 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 12 5 11490 23702 0.0010432968179447 0.000539199208333142 0.00182171963730016 0.999789091829417 0.999507879904061 0.999931515258336 0.705882352941176 0.440417281245662 0.89686448562968 0 0 0.602364635616474 0 0 0.521823750104981 0 0 3.12548030073338 0.310871233304791 299 3890 False False 0 0 0 0 0 0 0 4.9508093994778 1.62299244869797 17.9424005784271 0 0 0.000320999770035263 0.999789091829417 0.999507879904061 0.999931515258336 1 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-247T>G mtrA_c.-247T>G 2 upstream_gene_variant 3627596 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.249C>T mtrA_c.249C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.-250G>A mtrA_c.-250G>A 2 upstream_gene_variant 3627599 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.252A>C mtrA_c.252A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.-253C>G mtrA_c.-253C>G 2 upstream_gene_variant 3627602 1 4 0 4 3 4 16807 30528 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999868989912223 0.999664596427238 0.999964303043777 0.428571428571428 0.0989882784425078 0.815948432359917 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.75191523168538 0.304360274269881 360.5 4649 False False 1.36228952222288 0.19952864446048 8.05486976701789 0 0 0.000219460621016169 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 3 4 11499 23703 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.999831273463534 0.999568049920357 0.99995402584539 0.428571428571428 0.0989882784425078 0.815948432359917 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12316517643725 0.310812581812229 294.5 3890 False False 0 0 0 0 0 0 0 1.54598225932689 0.226418767059518 9.13992940102341 0 0 0.000320748571273651 0.999831273463534 0.999568049920357 0.99995402584539 1 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-253C>T mtrA_c.-253C>T 2 upstream_gene_variant 3627602 1 23 1 22 16 38 16794 30494 0.000951814396192742 0.000544138942285324 0.00154522796648703 0.99875540416612 0.998292091113034 0.999119104044951 0.296296296296296 0.179780374511259 0.4360907292974 0.0434782608695652 0.0011001686304415 0.21948660745348 0.0256410256410256 0.000648963895481945 0.134763921559497 0.0825348880011259 0.00200389523709181 0.510713466196691 0.000766534888475688 67 4649 False False 0.76453369937885 0.397890768508774 1.40469605826334 5.95415302173265e-05 1.50745989291426e-06 0.000331699026023794 0.99875540416612 0.998292091113034 0.999119104044951 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 20 1 19 15 33 11487 23674 0.00130412102243088 0.000730084557867185 0.00215003854003137 0.998608006074155 0.998045673252633 0.99904162771295 0.3125 0.186596283096012 0.462513578105436 0.05 0.0012650894979498 0.248732762772027 0.0294117647058823 0.00074436423469026 0.153267669560317 0.1084704448507 0.00261440720454311 0.682536985589064 0.00695798756105692 68 3890 False False 0 0 0 0 0 0 0 0.936790205528779 0.472581007767573 1.77426146699866 8.70473537604456e-05 2.20384575957588e-06 0.000484900322174504 0.998608006074155 0.998045673252633 0.99904162771295 3 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-256T>G mtrA_c.-256T>G 2 upstream_gene_variant 3627605 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.258C>T mtrA_c.258C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.-259C>T mtrA_c.-259C>T 2 upstream_gene_variant 3627608 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-25A>G mtrA_c.-25A>G 2 upstream_gene_variant 3627374 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3927 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3296 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-260G>A mtrA_c.-260G>A 2 upstream_gene_variant 3627609 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-263G>A mtrA_c.-263G>A 2 upstream_gene_variant 3627612 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3908 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3280 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-264C>T mtrA_c.-264C>T 2 upstream_gene_variant 3627613 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-268A>G mtrA_c.-268A>G 2 upstream_gene_variant 3627617 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-269G>A mtrA_c.-269G>A 2 upstream_gene_variant 3627618 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.270T>C mtrA_c.270T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.-274G>A mtrA_c.-274G>A 2 upstream_gene_variant 3627623 1 1 0 1 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 70.7668929171829 1 1627.5 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 0 0 0.000219447565534303 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-275G>T mtrA_c.-275G>T 2 upstream_gene_variant 3627624 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.276G>A mtrA_c.276G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.-276G>T mtrA_c.-276G>T 2 upstream_gene_variant 3627625 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.277C>T mtrA_c.277C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 4 16809 30528 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999868989912223 0.999664596427238 0.999964303043777 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.454042477244333 0.00922341562850508 4.58878013974823 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 3 11501 23704 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.99987345509765 0.999630227076139 0.999973902638554 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.687012723531287 0.0130900577164196 8.55773267307823 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.-277C>T mtrA_c.-277C>T 2 upstream_gene_variant 3627626 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3889 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.279G>A mtrA_c.279G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.279G>T mtrA_c.279G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.282T>C mtrA_c.282T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.282T>G mtrA_c.282T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.-287C>T mtrA_c.-287C>T 2 upstream_gene_variant 3627636 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-288G>A mtrA_c.-288G>A 2 upstream_gene_variant 3627637 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-290C>T mtrA_c.-290C>T 2 upstream_gene_variant 3627639 1 7 0 7 0 7 16810 30525 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 1.26007067420399 0.0561478031672613 154 4649 False False 0 0 1.26007067420399 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 2.24912710990902 0.180424970179968 177 3890 False False 0 0 0 0 0 0 0 0 0 2.24912710990902 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.291G>T mtrA_c.291G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.-292C>T mtrA_c.-292C>T 2 upstream_gene_variant 3627641 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.294C>T mtrA_c.294C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.-296C>T mtrA_c.-296C>T 2 upstream_gene_variant 3627645 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.297C>T mtrA_c.297C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.300C>T mtrA_c.300C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.-304G>A mtrA_c.-304G>A 2 upstream_gene_variant 3627653 NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3903 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3276 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-306G>C mtrA_c.-306G>C 2 upstream_gene_variant 3627655 NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3913 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-307G>A mtrA_c.-307G>A 2 upstream_gene_variant 3627656 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-312T>C mtrA_c.-312T>C 2 upstream_gene_variant 3627661 NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3914 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3284 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-313C>T mtrA_c.-313C>T 2 upstream_gene_variant 3627662 NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3884 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3261 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-315G>A mtrA_c.-315G>A 2 upstream_gene_variant 3627664 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-316C>A mtrA_c.-316C>A 2 upstream_gene_variant 3627665 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.318G>T mtrA_c.318G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.321C>T mtrA_c.321C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 27 16806 30505 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999115681907506 0.998713622442022 0.999417150456935 0.129032258064516 0.036301661979209 0.298335829007797 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.26890748894795 0.0683908712056223 0.771972786589055 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 4 26 11498 23681 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 0.99890327751297 0.998393457445096 0.999283463292248 0.133333333333333 0.0375534963383633 0.307218350276126 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.316857781286377 0.0803580029257047 0.913662373076151 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.-322C>T mtrA_c.-322C>T 2 upstream_gene_variant 3627671 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.324G>A mtrA_c.324G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.-327T>C mtrA_c.-327T>C 2 upstream_gene_variant 3627676 NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3909 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3281 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.330G>A mtrA_c.330G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.-339G>A mtrA_c.-339G>A 2 upstream_gene_variant 3627688 NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3887 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3263 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-34_-33delTG mtrA_c.-34_-33delTG 2 upstream_gene_variant 3627381 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-341T>A mtrA_c.-341T>A 2 upstream_gene_variant 3627690 NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3882 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3259 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-343A>G mtrA_c.-343A>G 2 upstream_gene_variant 3627692 1 1 1 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0465715996825058 Inf 0.355075831185839 416 4649 False False Inf 0.0465715996825058 Inf 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.351G>A mtrA_c.351G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.-35G>A mtrA_c.-35G>A 2 upstream_gene_variant 3627384 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-364G>A mtrA_c.-364G>A 2 upstream_gene_variant 3627713 NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3904 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3277 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-364G>C mtrA_c.-364G>C 2 upstream_gene_variant 3627713 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-366G>A mtrA_c.-366G>A 2 upstream_gene_variant 3627715 1 0 0 0 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3925 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3294 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 4 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-36T>G mtrA_c.-36T>G 2 upstream_gene_variant 3627385 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-370G>A mtrA_c.-370G>A 2 upstream_gene_variant 3627719 NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3900 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3273 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-375G>A mtrA_c.-375G>A 2 upstream_gene_variant 3627724 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.381C>T mtrA_c.381C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.387G>A mtrA_c.387G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.393G>A mtrA_c.393G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.-39C>T mtrA_c.-39C>T 2 upstream_gene_variant 3627388 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-40C>T mtrA_c.-40C>T 2 upstream_gene_variant 3627389 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.411A>G mtrA_c.411A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.-41G>A mtrA_c.-41G>A 2 upstream_gene_variant 3627390 1 4 1 3 2 3 16808 30529 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999901742434167 0.999712876815577 0.99997973646933 0.4 0.0527449505263169 0.853367200365326 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.605445819451055 0.0115368514686733 7.54132084906832 1 938.5 4649 False False 1.21089163890211 0.101157890363798 10.5697741171107 5.94919388422868e-05 1.50620434989522e-06 0.000331422795737767 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 1 3 2 3 11500 23704 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.99987345509765 0.999630227076139 0.999973902638554 0.4 0.0527449505263169 0.853367200365326 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.687072463768115 0.0130911954325027 8.55847696125381 1 1214.5 3890 False False 0 0 0 0 0 0 0 1.37414492753623 0.114734681491877 11.9942804069209 8.69489609599165e-05 2.20135467503192e-06 0.000484352330576856 0.99987345509765 0.999630227076139 0.999973902638554 2 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.432G>A mtrA_c.432G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.438T>C mtrA_c.438T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.441C>G mtrA_c.441C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.341150751115529 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.441C>T mtrA_c.441C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 12 16807 30520 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999606969736669 0.999313555980458 0.999796899563454 0.2 0.0433120051058366 0.480891133806853 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.453977509371095 0.0821993616975522 1.68254175655497 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 11 11499 23696 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.999536002024718 0.999169931473241 0.999768351851939 0.214285714285714 0.0465792878898673 0.507975677048471 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.562009344686099 0.100646994477913 2.12814636090958 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.444C>T mtrA_c.444C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.468G>C mtrA_c.468G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.468G>T mtrA_c.468G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.477C>T mtrA_c.477C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 6 3 16804 30529 0.000356930398572278 0.000130998068917797 0.000776724091447791 0.999901742434167 0.999712876815577 0.99997973646933 0.666666666666666 0.29929505620854 0.925145368580308 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.63353963342061 0.775880513842457 22.4552956007886 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 6 2 11496 23705 0.000521648408972352 0.000191459062774625 0.00113506056981396 0.999915636731767 0.999695284447545 0.999989783053538 0.75 0.349144205587175 0.968145973750055 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 6.18606471816283 1.10590335698881 62.723657220841 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.480C>T mtrA_c.480C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.481C>T mtrA_c.481C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.486G>A mtrA_c.486G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.489C>A mtrA_c.489C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.-49C>T mtrA_c.-49C>T 2 upstream_gene_variant 3627398 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3299 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.504G>A mtrA_c.504G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.-51A>C mtrA_c.-51A>C 2 upstream_gene_variant 3627400 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.51G>A mtrA_c.51G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.525T>A mtrA_c.525T>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.525T>C mtrA_c.525T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.534G>A mtrA_c.534G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.546A>G mtrA_c.546A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.558G>T mtrA_c.558G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.561C>T mtrA_c.561C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.564A>G mtrA_c.564A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.573C>T mtrA_c.573C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.576G>A mtrA_c.576G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.750576632084797 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.57G>A mtrA_c.57G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 21 16808 30511 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999312197039172 0.998948811248646 0.999574190302931 0.0869565217391304 0.0107099660378758 0.280379335909411 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.172882527594569 0.0196555409248292 0.707418946198769 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 20 11500 23687 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.99915636731767 0.998697376967606 0.99948461349205 0.0909090909090909 0.0112055860241509 0.291612741553933 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.205973913043478 0.0233643584771898 0.848168983349934 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.-57T>C mtrA_c.-57T>C 2 upstream_gene_variant 3627406 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-57T>G mtrA_c.-57T>G 2 upstream_gene_variant 3627406 1 7 0 7 2 7 16808 30525 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.99977073234639 0.999527678427408 0.999907817703152 0.222222222222222 0.0281449734778982 0.600093573716312 0 0 0.409616397225003 0 0 0.409616397225003 0 0 1.26022062846726 0.0561573620496189 165 4649 False False 0.518885564697083 0.0525913141752312 2.72565212094981 0 0 0.000219447565534303 0.99977073234639 0.999527678427408 0.999907817703152 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 1 4 11501 23703 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999831273463534 0.999568049920357 0.99995402584539 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12262191820896 0.310798846422045 285 3890 False False 0 0 0 0 0 0 0 0.515237805408225 0.0104655802548345 5.20753049950472 0 0 0.000320692802708327 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.582G>C mtrA_c.582G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.582G>T mtrA_c.582G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.585C>T mtrA_c.585C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.588G>C mtrA_c.588G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.591T>C mtrA_c.591T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.594C>G mtrA_c.594C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.601C>T mtrA_c.601C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 2 16806 30530 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999934494956111 0.999763393503742 0.99999206693684 0.666666666666666 0.222778095503512 0.956728131707258 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.63322622872783 0.520625747830046 40.1764939558657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 4 1 11498 23706 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 0.999957818365883 0.999765001636458 0.999998932054057 0.8 0.28358206388191 0.994949236620532 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 8.24699947817011 0.815939832795188 405.284913246419 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.609C>G mtrA_c.609C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.609C>T mtrA_c.609C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.-60C>T mtrA_c.-60C>T 2 upstream_gene_variant 3627409 1 6 1 5 1 6 16809 30526 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999803484868334 0.999572318737888 0.999927879105266 0.142857142857142 0.00361029686190058 0.578723197043195 0.166666666666666 0.00421074451448947 0.641234578997674 0.142857142857142 0.00361029686190058 0.578723197043195 0.363210185019929 0.00768300324245307 3.24664275682703 0.432628772830379 441 4649 False False 0.302675154183274 0.00658396461982027 2.49513982006856 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999803484868334 0.999572318737888 0.999927879105266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 1 5 1 5 11501 23702 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999789091829417 0.999507879904061 0.999931515258336 0.166666666666666 0.00421074451448947 0.641234578997674 0.166666666666666 0.00421074451448947 0.641234578997674 0.166666666666666 0.00421074451448947 0.641234578997674 0.412172854534388 0.00871781959321125 3.68423590106777 0.670951745203564 492 3890 False False 0 0 0 0 0 0 0 0.412172854534388 0.00871781959321125 3.68423590106777 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999789091829417 0.999507879904061 0.999931515258336 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-61G>A mtrA_c.-61G>A 2 upstream_gene_variant 3627410 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.627C>T mtrA_c.627C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.636G>A mtrA_c.636G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.642G>A mtrA_c.642G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.642G>C mtrA_c.642G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.651C>T mtrA_c.651C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.-67G>A mtrA_c.-67G>A 2 upstream_gene_variant 3627416 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.684G>A mtrA_c.684G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.-68G>C mtrA_c.-68G>C 2 upstream_gene_variant 3627417 NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3928 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3297 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-69G>A mtrA_c.-69G>A 2 upstream_gene_variant 3627418 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-69G>C mtrA_c.-69G>C 2 upstream_gene_variant 3627418 NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3888 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3264 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 3 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.72G>A mtrA_c.72G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.73C>T mtrA_c.73C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.-73T>G mtrA_c.-73T>G 2 upstream_gene_variant 3627422 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3883 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3260 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-74G>A mtrA_c.-74G>A 2 upstream_gene_variant 3627423 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3921 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3291 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-78C>T mtrA_c.-78C>T 2 upstream_gene_variant 3627427 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.78G>A mtrA_c.78G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.-80T>C mtrA_c.-80T>C 2 upstream_gene_variant 3627429 NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3896 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.81G>A mtrA_c.81G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.81G>T mtrA_c.81G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrA c.-82C>A mtrA_c.-82C>A 2 upstream_gene_variant 3627431 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-83A>G mtrA_c.-83A>G 2 upstream_gene_variant 3627432 1 1 0 1 8 1 16802 30531 0.000475907198096371 0.00020548462525215 0.000937510381255989 0.999967247478055 0.999817528289014 0.999999170778282 0.888888888888888 0.517503485082663 0.9971908632534 0 0 0.975 0 0 0.975 0 0 70.7921358462643 1 938.5 4649 False False 14.5368408522794 1.94857414115003 643.047530935858 0 0 0.000219525921733526 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 6 1 11496 23706 0.000521648408972352 0.000191459062774625 0.00113506056981396 0.999957818365883 0.999765001636458 0.999998932054057 0.857142857142857 0.421276802956804 0.996389703138099 0 0 0.975 0 0 0.975 0 0 80.3259397723806 1 1214.5 3890 False False 0 0 0 0 0 0 0 12.3726513569937 1.50072525153826 567.507166587209 0 0 0.000320832260499258 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-85A>G mtrA_c.-85A>G 2 upstream_gene_variant 3627434 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3931 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3298 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-88T>C mtrA_c.-88T>C 2 upstream_gene_variant 3627437 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3905 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3278 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-93G>A mtrA_c.-93G>A 2 upstream_gene_variant 3627442 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-98C>T mtrA_c.-98C>T 2 upstream_gene_variant 3627447 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA c.-9G>A mtrA_c.-9G>A 2 upstream_gene_variant 3627358 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3915 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3285 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA p.Ala134Val mtrA_p.Ala134Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3912 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA p.Ala225Val mtrA_p.Ala225Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA p.Ala44Ser mtrA_p.Ala44Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3929 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA p.Ala44Thr mtrA_p.Ala44Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA p.Arg122Ser mtrA_p.Arg122Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3897 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3271 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA p.Arg167Ser mtrA_p.Arg167Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3901 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3274 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA p.Arg26Trp mtrA_p.Arg26Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA p.Arg5Lys mtrA_p.Arg5Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 1 5 16809 30527 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999836237390279 0.999617874429585 0.999946824656822 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.98214103142536 0.168452649138924 269 4649 False False 0.363222083407698 0.00768325476784986 3.24674897733262 0 0 0.000219434511605659 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 2.24912710990902 0.180424970179968 177 3890 False False 0 0 0 0 0 0 0 0 0 2.24912710990902 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA p.Arg5Thr mtrA_p.Arg5Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 7 16810 30525 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 1.26007067420399 0.0561478031672613 154 4649 False False 0 0 1.26007067420399 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA p.Arg7Met mtrA_p.Arg7Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3923 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA p.Asn148Lys mtrA_p.Asn148Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA p.Asn148Ser mtrA_p.Asn148Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.9820231071276 0.168448731581911 252 4649 False False 0 0 1.9820231071276 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 2.24912710990902 0.180424970179968 177 3890 False False 0 0 0 0 0 0 0 0 0 2.24912710990902 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA p.Asp124Glu mtrA_p.Asp124Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3894 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3269 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA p.Gln151His mtrA_p.Gln151His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3919 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3289 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA p.Gln181Lys mtrA_p.Gln181Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3911 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3283 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA p.Glu129Asp mtrA_p.Glu129Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA p.Glu150Lys mtrA_p.Glu150Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA p.Glu47Gly mtrA_p.Glu47Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 20 0 20 0 24 16810 30508 0 0 0.000219421459229958 0.999213939473339 0.99883062854842 0.999496293299407 0 0 0.142473597722525 0 0 0.168433470983085 0 0 0.142473597722525 0 0 0.367657075050613 0.00021544000743997 57 4649 True False 0 0 0.301561526904413 0 0 0.000219421459229958 0.999213939473339 0.99883062854842 0.999496293299407 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 20 0 20 0 24 11502 23683 0 0 0.000320664925697395 0.998987640781203 0.998494061778372 0.999351258026211 0 0 0.142473597722525 0 0 0.168433470983085 0 0 0.142473597722525 0 0 0.417132702956591 0.000494414694556569 43 3890 True False 0 0 0 0 0 0 0 0 0 0.342183638258491 0 0 0.000320664925697395 0.998987640781203 0.998494061778372 0.999351258026211 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA p.Gly27Arg mtrA_p.Gly27Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA p.Gly29Ser mtrA_p.Gly29Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3885 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA p.Gly36Cys mtrA_p.Gly36Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3898 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3272 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA p.Ile152Phe mtrA_p.Ile152Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3907 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3279 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA p.Ile79Val mtrA_p.Ile79Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA p.Leu165Met mtrA_p.Leu165Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3930 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA p.Leu52Val mtrA_p.Leu52Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 2 16808 30530 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999934494956111 0.999763393503742 0.99999206693684 0.5 0.067585986488543 0.932414013511457 1 0.158113883008419 1 0.5 0.067585986488543 0.932414013511457 Inf 0.341128396083888 Inf 0.126084661690076 226.5 4649 False False 1.8163969538315 0.131636449523742 25.0652602654423 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3300 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 1 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA p.Lys144Met mtrA_p.Lys144Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 26 0 26 1 28 16809 30504 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999082929385562 0.99867484826652 0.999390529439302 0.0344827586206896 0.000872646883579922 0.177644295488722 0 0 0.132274604497754 0 0 0.123436118500263 0 0 0.276688278985518 1.40975280208445e-05 40 4649 True False 0.0648122179444685 0.00158913834386129 0.392104547085416 0 0 0.000219434511605659 0.999082929385562 0.99867484826652 0.999390529439302 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 23 0 23 1 24 11501 23683 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.998987640781203 0.998494061778372 0.999351258026211 0.04 0.00101219969931084 0.203516913922414 0 0 0.148185128915224 0 0 0.142473597722525 0 0 0.358313616473043 0.00017249793190685 40 3890 True False 0 0 0 0 0 0 0 0.0858005101005709 0.00209037908451614 0.526292931423827 0 0 0.000320692802708327 0.998987640781203 0.998494061778372 0.999351258026211 2 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA p.Lys224Arg mtrA_p.Lys224Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA p.Met104Ile mtrA_p.Met104Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA p.Met62Ile mtrA_p.Met62Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3895 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3270 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA p.Pro109Leu mtrA_p.Pro109Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA p.Pro127Ser mtrA_p.Pro127Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3891 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3266 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA p.Pro169Arg mtrA_p.Pro169Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3916 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3286 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA p.Pro188Ala mtrA_p.Pro188Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3906 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA p.Pro50Ala mtrA_p.Pro50Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA p.Ser153Pro mtrA_p.Ser153Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA p.Ser75Phe mtrA_p.Ser75Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA p.Thr39Ile mtrA_p.Thr39Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA p.Thr3Asn mtrA_p.Thr3Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA p.Thr43Ile mtrA_p.Thr43Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA p.Thr86Ile mtrA_p.Thr86Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3886 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3262 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA p.Val116Met mtrA_p.Val116Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3922 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3292 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA p.Val140Leu mtrA_p.Val140Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.75142405620251 0.304356294847217 327.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA p.Val205Ile mtrA_p.Val205Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 6 16809 30526 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999803484868334 0.999572318737888 0.999927879105266 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.707598226178713 0 0 0.4592581264399 0 0 4.39538229515893 0.556930483439971 918 4649 False False 0.302675154183274 0.00658396461982027 2.49513982006856 0 0 0.000219434511605659 0.999803484868334 0.999572318737888 0.999927879105266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 3 11501 23704 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.99987345509765 0.999630227076139 0.999973902638554 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 10.9722796976426 1 1214.5 3890 False False 0 0 0 0 0 0 0 0.687012723531287 0.0130900577164196 8.55773267307823 0 0 0.000320692802708327 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA p.Val218Ile mtrA_p.Val218Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3892 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3267 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA p.Val34Ile mtrA_p.Val34Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrA p.Val80Leu mtrA_p.Val80Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB c.1033C>A mtrB_c.1033C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 8 55 16802 30477 0.000475907198096371 0.00020548462525215 0.000937510381255989 0.998198611293069 0.997655882180225 0.998642668059806 0.126984126984126 0.0564512795453029 0.234965575695654 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.263838720498641 0.10850512921096 0.55730371795126 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 3 42 11499 23665 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.998228371367106 0.997606018992145 0.998722876779403 0.0666666666666666 0.0139650970443705 0.182684456578226 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 0 0.147000360279775 0.0291649109122764 0.460158998170264 NA NA NA NA NA NA 3 5) Not assoc w R Now listed Silent mutation no 0 +Rifampicin mtrB c.1045T>C mtrB_c.1045T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1053C>T mtrB_c.1053C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.75142405620251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1057C>T mtrB_c.1057C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1098G>A mtrB_c.1098G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1110G>A mtrB_c.1110G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.750576632084797 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1113C>A mtrB_c.1113C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 9 16810 30523 0 0 0.000219421459229958 0.999705227302502 0.999440503684993 0.999865202576615 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.920078094923294 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 9 11502 23698 0 0 0.000320664925697395 0.999620365292951 0.999279457952852 0.99982639261309 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.04405446176545 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1117T>C mtrB_c.1117T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1119G>A mtrB_c.1119G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.111G>T mtrB_c.111G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1122C>G mtrB_c.1122C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.112C>T mtrB_c.112C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1137C>T mtrB_c.1137C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1143C>A mtrB_c.1143C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.114G>T mtrB_c.114G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1179C>T mtrB_c.1179C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.117G>A mtrB_c.117G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.118C>T mtrB_c.118C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1191G>A mtrB_c.1191G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1195C>T mtrB_c.1195C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1197G>C mtrB_c.1197G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1200C>T mtrB_c.1200C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1206G>A mtrB_c.1206G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1215C>T mtrB_c.1215C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1263T>C mtrB_c.1263T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1266C>T mtrB_c.1266C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.126C>T mtrB_c.126C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1272C>G mtrB_c.1272C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 6 16809 30526 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999803484868334 0.999572318737888 0.999927879105266 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.302675154183274 0.00658396461982027 2.49513982006856 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.24912710990902 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1275C>T mtrB_c.1275C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1290C>T mtrB_c.1290C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.908144446427509 0.0153974005043644 17.4461131425891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1293A>G mtrB_c.1293A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1314C>T mtrB_c.1314C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1317C>T mtrB_c.1317C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1326C>T mtrB_c.1326C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.132G>A mtrB_c.132G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1332C>A mtrB_c.1332C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.133C>T mtrB_c.133C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1347T>C mtrB_c.1347T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1350C>T mtrB_c.1350C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.341150751115529 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1353C>T mtrB_c.1353C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.135G>T mtrB_c.135G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1362G>C mtrB_c.1362G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1365G>A mtrB_c.1365G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1386G>A mtrB_c.1386G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.138C>T mtrB_c.138C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1392T>C mtrB_c.1392T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.141T>A mtrB_c.141T>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1420C>A mtrB_c.1420C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1425A>G mtrB_c.1425A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1437C>T mtrB_c.1437C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 2 16808 30530 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999934494956111 0.999763393503742 0.99999206693684 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.8163969538315 0.131636449523742 25.0652602654423 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1443C>T mtrB_c.1443C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1452T>C mtrB_c.1452T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.145C>T mtrB_c.145C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1479A>G mtrB_c.1479A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.147G>A mtrB_c.147G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 282 1083 16528 29449 0.016775728732897 0.014888466277116 0.0188327308846203 0.964529018734442 0.96239321061623 0.966575841678742 0.206593406593406 0.185399259663376 0.229058359408674 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.463949701404885 0.404958973678173 0.530142185664928 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 181 803 11321 22904 0.0157363936706659 0.013541715003094 0.0181808689535151 0.966128147804446 0.963746416805308 0.968394693430278 0.183943089430894 0.160201784452242 0.20959203110335 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 0 0.456025968337311 0.385333363778581 0.537357282442192 NA NA NA NA NA NA 279 5) Not assoc w R Now listed Silent mutation no 0 +Rifampicin mtrB c.-14A>C mtrB_c.-14A>C 2 upstream_gene_variant 3626627 1 0 0 0 1 3 16809 30529 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999901742434167 0.999712876815577 0.99997973646933 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3322 4649 False False 0.605409800305391 0.0115361654751757 7.54087213596152 0 0 0.000219434511605659 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2758 3890 False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 0 0 0.000320692802708327 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB c.1503G>A mtrB_c.1503G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1509C>A mtrB_c.1509C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1509C>T mtrB_c.1509C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1515C>T mtrB_c.1515C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1524C>T mtrB_c.1524C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 2 16808 30530 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999934494956111 0.999763393503742 0.99999206693684 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.8163969538315 0.131636449523742 25.0652602654423 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1533C>T mtrB_c.1533C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.153A>G mtrB_c.153A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.9820231071276 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.24912710990902 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.153A>T mtrB_c.153A>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1554G>A mtrB_c.1554G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1582C>T mtrB_c.1582C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.9820231071276 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1608A>C mtrB_c.1608A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1620G>A mtrB_c.1620G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1632G>C mtrB_c.1632G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.163C>T mtrB_c.163C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1653G>A mtrB_c.1653G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1653G>T mtrB_c.1653G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.908144446427509 0.0153974005043644 17.4461131425891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1662G>A mtrB_c.1662G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1677A>G mtrB_c.1677A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1686C>T mtrB_c.1686C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.171T>C mtrB_c.171T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.174C>T mtrB_c.174C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.341150751115529 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.186C>T mtrB_c.186C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 8 16810 30524 0 0 0.000219421459229958 0.999737979824446 0.999483781433772 0.999886871715824 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.06393155676265 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.24912710990902 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.189C>T mtrB_c.189C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.192G>A mtrB_c.192G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.198C>T mtrB_c.198C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 12 16808 30520 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999606969736669 0.999313555980458 0.999796899563454 0.142857142857142 0.0177945154831915 0.428129160909698 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.302633666508012 0.032889580275051 1.35967332152622 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 8 11501 23699 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999662546927068 0.999335191784523 0.999854300817065 0.111111111111111 0.00280913674659921 0.482496514917337 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.257575428223632 0.00580827991067691 1.92165917942206 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.1A>G mtrB_c.1A>G 2 initiator_codon_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.201T>C mtrB_c.201T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.207C>T mtrB_c.207C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.-20G>A mtrB_c.-20G>A 2 upstream_gene_variant 3626633 1 11 0 11 14 16 16796 30516 0.000832837596668649 0.000455392489979272 0.00139696554892221 0.999475959648893 0.999149130429312 0.999700436936355 0.466666666666666 0.283418079183537 0.656744761839265 0 0 0.284914152918154 0 0 0.205907214207822 0 0 0.72400644666324 0.0103229921523277 107 4649 False False 1.58975351274112 0.718383132785925 3.47710912693803 0 0 0.000219604333908644 0.999475959648893 0.999149130429312 0.999700436936355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 7 12 11495 23695 0.000608589810467744 0.000244718560881119 0.00125352303681455 0.999493820390602 0.999115973206486 0.999738423129043 0.368421052631578 0.162885872155099 0.616422076685594 0 0 0.369416647552819 0 0 0.264648469397051 0 0 1.20784911775994 0.0599365856432407 122 3890 False False 0 0 0 0 0 0 0 1.20244309119907 0.400980046839727 3.31384301815764 0 0 0.000320860166613556 0.999493820390602 0.999115973206486 0.999738423129043 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB c.210C>T mtrB_c.210C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.216C>T mtrB_c.216C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.-23A>C mtrB_c.-23A>C 2 upstream_gene_variant 3626636 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB c.-23A>G mtrB_c.-23A>G 2 upstream_gene_variant 3626636 1 4 0 4 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 2.75133392880791 0.304355565478378 305.5 4649 False False 0 0 1.9820231071276 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 3.12221861743114 0.310788655266302 237.5 3890 False False 0 0 0 0 0 0 0 0 0 2.24912710990902 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB c.243C>T mtrB_c.243C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.24C>T mtrB_c.24C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.908144446427509 0.0153974005043644 17.4461131425891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.-24C>T mtrB_c.-24C>T 2 upstream_gene_variant 3626637 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB c.252A>G mtrB_c.252A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.255C>T mtrB_c.255C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.276C>G mtrB_c.276C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.-27G>A mtrB_c.-27G>A 2 upstream_gene_variant 3626640 NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3285 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2729 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB c.-27G>T mtrB_c.-27G>T 2 upstream_gene_variant 3626640 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB c.291G>A mtrB_c.291G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.297A>C mtrB_c.297A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.297A>G mtrB_c.297A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.306T>C mtrB_c.306T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.309C>T mtrB_c.309C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 6 141 16804 30391 0.000356930398572278 0.000130998068917797 0.000776724091447791 0.995381894405869 0.994555908349798 0.996111315031264 0.0408163265306122 0.015123889442704 0.0867209710167973 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.0769598930345865 0.0277479271001652 0.171790432060496 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 4 135 11498 23572 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 0.994305479394271 0.993263373209886 0.995223416269876 0.0287769784172661 0.00789528003935209 0.0720402366632219 NA NA NA NA NA NA NA NA NA NA NA NA False True 1 1 1 0 0 0 0 0.0607435753722064 0.0163089805059005 0.159226759342759 NA NA NA NA NA NA 8 5) Not assoc w R Now listed Silent mutation no 0 +Rifampicin mtrB c.30G>A mtrB_c.30G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.318T>C mtrB_c.318T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.-31C>T mtrB_c.-31C>T 2 upstream_gene_variant 3626644 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3276 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2724 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB c.330T>C mtrB_c.330T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.330T>G mtrB_c.330T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.333G>A mtrB_c.333G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.33T>C mtrB_c.33T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 8 16810 30524 0 0 0.000219421459229958 0.999737979824446 0.999483781433772 0.999886871715824 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.06393155676265 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 8 11502 23699 0 0 0.000320664925697395 0.999662546927068 0.999335191784523 0.999854300817065 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.20731769892417 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.-33T>C mtrB_c.-33T>C 2 upstream_gene_variant 3626646 1 2 0 2 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 9.67028206568003 0.541992006917746 476.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 10.9713274274722 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB c.-33T>G mtrB_c.-33T>G 2 upstream_gene_variant 3626646 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB c.345C>T mtrB_c.345C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.354T>C mtrB_c.354T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.9820231071276 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.354T>G mtrB_c.354T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.363T>G mtrB_c.363T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 15 31 16795 30501 0.000892325996430696 0.000499511372123772 0.00147132963433071 0.99898467181973 0.998559129586524 0.999310032760287 0.326086956521739 0.195325436673894 0.480172040637534 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.878746554754199 0.440698201339582 1.6780288170388 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 14 25 11488 23682 0.00121717962093548 0.000665598145642159 0.00204137811638842 0.998945459147087 0.998443680572118 0.999317444144018 0.358974358974359 0.212037185560799 0.528204886374588 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.15441504178273 0.554517958208334 2.30896020240849 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.369C>G mtrB_c.369C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.378G>T mtrB_c.378G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.384T>C mtrB_c.384T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 3 16809 30529 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999901742434167 0.999712876815577 0.99997973646933 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.605409800305391 0.0115361654751757 7.54087213596152 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 3 11501 23704 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.99987345509765 0.999630227076139 0.999973902638554 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.687012723531287 0.0130900577164196 8.55773267307823 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.-38G>A mtrB_c.-38G>A 2 upstream_gene_variant 3626651 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3273 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2721 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB c.390G>A mtrB_c.390G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 18 16807 30514 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999410454605004 0.999068423526975 0.999650561796013 0.142857142857142 0.0304889676215155 0.363423987016981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.302592173895797 0.0570930355428442 1.03674460439863 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 14 11501 23693 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999409457122369 0.999009367705732 0.999677108302285 0.0666666666666666 0.0016864302413527 0.319484566578303 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.147148695144521 0.00348375000880481 0.967404595956322 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.405T>C mtrB_c.405T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.9820231071276 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.408T>C mtrB_c.408T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.411G>C mtrB_c.411G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.420T>C mtrB_c.420T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.420T>G mtrB_c.420T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.429T>G mtrB_c.429T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.441C>T mtrB_c.441C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.-44G>A mtrB_c.-44G>A 2 upstream_gene_variant 3626657 NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3289 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2733 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB c.-44G>C mtrB_c.-44G>C 2 upstream_gene_variant 3626657 1 6 0 6 0 8 16810 30524 0 0 0.000219421459229958 0.999737979824446 0.999483781433772 0.999886871715824 0 0 0.369416647552819 0 0 0.4592581264399 0 0 0.369416647552819 0 0 1.54241302632406 0.0957730714925599 184.5 4649 False False 0 0 1.06393155676265 0 0 0.000219421459229958 0.999737979824446 0.999483781433772 0.999886871715824 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 8 11502 23699 0 0 0.000320664925697395 0.999662546927068 0.999335191784523 0.999854300817065 0 0 0.369416647552819 0 0 0.4592581264399 0 0 0.369416647552819 0 0 1.75023866430665 0.186842544675657 221.5 3890 False False 0 0 0 0 0 0 0 0 0 1.20731769892417 0 0 0.000320664925697395 0.999662546927068 0.999335191784523 0.999854300817065 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB c.450G>A mtrB_c.450G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.453C>T mtrB_c.453C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 2 16808 30530 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999934494956111 0.999763393503742 0.99999206693684 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.8163969538315 0.131636449523742 25.0652602654423 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.45C>T mtrB_c.45C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.460C>T mtrB_c.460C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.471C>T mtrB_c.471C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.-47C>T mtrB_c.-47C>T 2 upstream_gene_variant 3626660 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB c.480C>T mtrB_c.480C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.489C>A mtrB_c.489C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 4 16807 30528 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999868989912223 0.999664596427238 0.999964303043777 0.428571428571428 0.0989882784425078 0.815948432359917 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.36228952222288 0.19952864446048 8.05486976701789 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.492C>G mtrB_c.492C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.495C>T mtrB_c.495C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 1 16807 30531 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999967247478055 0.999817528289014 0.999999170778282 0.75 0.194120449683243 0.99369053679029 NA NA NA NA NA NA NA NA NA NA NA NA False False 5.44969358005592 0.437509494081317 285.652299683162 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 1 11499 23706 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.999957818365883 0.999765001636458 0.999998932054057 0.75 0.194120449683243 0.99369053679029 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 6.18471171406209 0.496496186771195 324.103527365594 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.504C>T mtrB_c.504C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.516C>G mtrB_c.516C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.516C>T mtrB_c.516C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.51C>G mtrB_c.51C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.51C>T mtrB_c.51C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.534G>T mtrB_c.534G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.558G>A mtrB_c.558G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.573C>T mtrB_c.573C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 16810 30526 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.54251408011679 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.579G>A mtrB_c.579G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.589C>T mtrB_c.589C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 6 11 16804 30521 0.000356930398572278 0.000130998068917797 0.000776724091447791 0.999639722258614 0.999355455254591 0.999820137367966 0.352941176470588 0.14209748311022 0.616716336556597 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.990705676137716 0.30078364952977 2.92317510201488 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 7 11500 23700 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999704728561184 0.999391723222185 0.999881277590374 0.222222222222222 0.0281449734778982 0.600093573716312 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.588819875776397 0.0596633171436625 3.09306705863206 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.-5C>T mtrB_c.-5C>T 2 upstream_gene_variant 3626618 NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3294 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB c.606G>C mtrB_c.606G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.606G>T mtrB_c.606G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.61C>A mtrB_c.61C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.651C>T mtrB_c.651C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.664C>T mtrB_c.664C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.908144446427509 0.0153974005043644 17.4461131425891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.666G>A mtrB_c.666G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.667C>T mtrB_c.667C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.66C>T mtrB_c.66C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 8 10 16802 30522 0.000475907198096371 0.00020548462525215 0.000937510381255989 0.999672474780558 0.999397752220648 0.999842928110511 0.444444444444444 0.215301507387299 0.692428341001244 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.45325556481371 0.498331133100885 4.09081365557157 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 7 8 11495 23699 0.000608589810467744 0.000244718560881119 0.00125352303681455 0.999662546927068 0.999335191784523 0.999854300817065 0.466666666666666 0.212666729519307 0.734138652722603 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.80396911700739 0.556712084740923 5.69413894160877 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.673C>T mtrB_c.673C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 14 16809 30518 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999541464692781 0.999230775228684 0.999749292529582 0.0666666666666666 0.0016864302413527 0.319484566578303 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.129683927827779 0.00307091319956987 0.852531396269756 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.24912710990902 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.678C>G mtrB_c.678C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.684C>T mtrB_c.684C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.693G>A mtrB_c.693G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.9820231071276 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.696G>A mtrB_c.696G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.69C>T mtrB_c.69C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.723G>A mtrB_c.723G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.723G>T mtrB_c.723G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.726G>A mtrB_c.726G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.732G>A mtrB_c.732G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.735G>A mtrB_c.735G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 16810 30526 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.54251408011679 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 6 11502 23701 0 0 0.000320664925697395 0.9997469101953 0.999449212060655 0.99990711502044 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.75038628279554 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.738G>C mtrB_c.738G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.741C>T mtrB_c.741C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.747A>G mtrB_c.747A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.750T>C mtrB_c.750T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.759G>A mtrB_c.759G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.75G>T mtrB_c.75G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.762A>G mtrB_c.762A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.766C>T mtrB_c.766C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.76T>C mtrB_c.76T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.777C>G mtrB_c.777C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.78G>A mtrB_c.78G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.795G>A mtrB_c.795G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.801C>T mtrB_c.801C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 11 16808 30521 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999639722258614 0.999355455254591 0.999820137367966 0.153846153846153 0.0192066719825284 0.454471055676557 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.330156635368439 0.0355444411539774 1.51305580967864 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 10 11500 23697 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999578183658835 0.999224402000993 0.999797704727851 0.166666666666666 0.0208625254600923 0.484137748685967 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.412121739130434 0.0439010319728098 1.93437051102569 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.807C>G mtrB_c.807C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.808A>C mtrB_c.808A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.813G>A mtrB_c.813G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.819G>A mtrB_c.819G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.822G>T mtrB_c.822G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 11 16810 30521 0 0 0.000219421459229958 0.999639722258614 0.999355455254591 0.999820137367966 0 0 0.284914152918154 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.723522114724776 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 11 11502 23696 0 0 0.000320664925697395 0.999536002024718 0.999169931473241 0.999768351851939 0 0 0.284914152918154 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.821023972766749 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.840G>A mtrB_c.840G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.843C>T mtrB_c.843C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.341150751115529 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.846G>A mtrB_c.846G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.849C>G mtrB_c.849C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.852A>G mtrB_c.852A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.852A>T mtrB_c.852A>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.864G>A mtrB_c.864G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.867G>C mtrB_c.867G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.870G>A mtrB_c.870G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.879C>A mtrB_c.879C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.87C>A mtrB_c.87C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.87C>T mtrB_c.87C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.882C>T mtrB_c.882C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.885A>C mtrB_c.885A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.885A>G mtrB_c.885A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.894G>C mtrB_c.894G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.903C>G mtrB_c.903C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.903C>T mtrB_c.903C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.906C>T mtrB_c.906C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.909C>G mtrB_c.909C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.90A>G mtrB_c.90A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.915C>T mtrB_c.915C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.927G>A mtrB_c.927G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.933G>A mtrB_c.933G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.936C>A mtrB_c.936C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.954C>T mtrB_c.954C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.958T>C mtrB_c.958T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.963C>A mtrB_c.963C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.969C>T mtrB_c.969C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.978C>G mtrB_c.978C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 7 16810 30525 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.26007067420399 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 7 11502 23700 0 0 0.000320664925697395 0.999704728561184 0.999391723222185 0.999881277590374 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.42986888806462 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.978C>T mtrB_c.978C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.981C>T mtrB_c.981C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.984C>T mtrB_c.984C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.994C>T mtrB_c.994C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB c.9C>T mtrB_c.9C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin mtrB LoF mtrB_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 4.39540875925228 0.556930310247326 910.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 4.98803779447094 0.555669835711629 381 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Ala107Val mtrB_p.Ala107Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Ala118Thr mtrB_p.Ala118Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3292 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2736 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Ala126Ser mtrB_p.Ala126Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3324 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2759 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Ala129Val mtrB_p.Ala129Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Ala140Thr mtrB_p.Ala140Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3310 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2749 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Ala144Gly mtrB_p.Ala144Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 11 0 16799 30532 0.00065437239738251 0.000326704163498642 0.00117055062018267 1 0.999879187193184 1 1 0.715085847081845 1 NA NA NA NA NA NA NA NA NA NA 3333 4649 False False Inf 4.56066720991606 Inf 0 0 0.000219565120820351 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 11 0 11491 23707 0.000956355416449313 0.000477502787107626 0.00171053820723243 1 0.999844409142079 1 1 0.715085847081845 1 NA NA NA NA NA NA NA NA NA NA 2769 3890 False False 0 0 0 0 0 0 0 Inf 5.1761760609822 Inf 0 0 0.000320971839633333 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Ala160Ser mtrB_p.Ala160Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Ala163Thr mtrB_p.Ala163Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Ala168Val mtrB_p.Ala168Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Ala202Val mtrB_p.Ala202Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Ala206Ser mtrB_p.Ala206Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3331 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2766 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Ala216Val mtrB_p.Ala216Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0465715996825058 Inf 0.355075831185839 416 4649 False False Inf 0.0465715996825058 Inf 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Ala227Ser mtrB_p.Ala227Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 2 4 16808 30528 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999868989912223 0.999664596427238 0.999964303043777 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.707598226178713 0 0 0.602364635616474 0 0 4.39593191955993 0.556926871343325 788 4649 False False 0.90813898143741 0.0821237468238322 6.33854635470206 0 0 0.000219447565534303 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Ala279Thr mtrB_p.Ala279Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Ala287Thr mtrB_p.Ala287Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3325 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2760 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Ala326Thr mtrB_p.Ala326Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3342 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2776 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Ala33Val mtrB_p.Ala33Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3283 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Ala438Thr mtrB_p.Ala438Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Ala492Thr mtrB_p.Ala492Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Ala501Ser mtrB_p.Ala501Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0465715996825058 Inf 0.355075831185839 416 4649 False False Inf 0.0465715996825058 Inf 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0528490600080728 Inf 0.32667783805277 340.5 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Ala563Val mtrB_p.Ala563Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Ala56Ser mtrB_p.Ala56Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 5 0 16805 30532 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 1 0.999879187193184 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 3326 4649 False False Inf 1.66460481015123 Inf 0 0 0.000219486736640675 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2761 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Ala77Thr mtrB_p.Ala77Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3278 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2725 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Arg13Trp mtrB_p.Arg13Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Arg250Cys mtrB_p.Arg250Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3353 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2786 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Arg259His mtrB_p.Arg259His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3295 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2738 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Arg263Gly mtrB_p.Arg263Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3315 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Arg298Gln mtrB_p.Arg298Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Arg358Trp mtrB_p.Arg358Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3290 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2734 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Arg35Leu mtrB_p.Arg35Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0465715996825058 Inf 0.355075831185839 416 4649 False False Inf 0.0465715996825058 Inf 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0528490600080728 Inf 0.32667783805277 340.5 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Arg374His mtrB_p.Arg374His 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Arg434Trp mtrB_p.Arg434Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Arg477Trp mtrB_p.Arg477Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3274 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2722 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Arg556Cys mtrB_p.Arg556Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Arg556Ser mtrB_p.Arg556Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Arg560Cys mtrB_p.Arg560Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Arg7Gly mtrB_p.Arg7Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Asn545_Met549delinsLys mtrB_p.Asn545_Met549delinsLys 2 inframe_deletion (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3291 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2735 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Asn545_Pro548del mtrB_p.Asn545_Pro548del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.9820231071276 0.168448731581911 252 4649 False False 0 0 1.9820231071276 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 2.24912710990902 0.180424970179968 177 3890 False False 0 0 0 0 0 0 0 0 0 2.24912710990902 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Asn545fs mtrB_p.Asn545fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3343 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2777 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Asn545Ser mtrB_p.Asn545Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Asp128Asn mtrB_p.Asp128Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Asp136Gly mtrB_p.Asp136Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3317 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2754 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Asp266Asn mtrB_p.Asp266Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3337 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2771 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Asp267Gly mtrB_p.Asp267Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 70.7668929171829 1 1627.5 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 0 0 0.000219447565534303 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Asp329Asn mtrB_p.Asp329Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2781 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Asp352Glu mtrB_p.Asp352Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Asp352Gly mtrB_p.Asp352Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3327 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2762 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Asp398Gly mtrB_p.Asp398Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.81634838479386 0.0231376410853604 142.42572627634 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Gln162Pro mtrB_p.Gln162Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Gln285Glu mtrB_p.Gln285Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3296 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2739 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Gln496His mtrB_p.Gln496His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3311 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2750 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Gln535Arg mtrB_p.Gln535Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3279 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2726 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Gln539* mtrB_p.Gln539* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Gln543* mtrB_p.Gln543* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Glu204Asp mtrB_p.Glu204Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.67117271135833 0.542004252564565 721 4649 False False 0.908144446427509 0.0153974005043644 17.4461131425891 0 0 0.000219434511605659 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2767 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Glu265Val mtrB_p.Glu265Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3308 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2747 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Glu342Ala mtrB_p.Glu342Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 3348 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 0 0 0.000219447565534303 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 2783 3890 False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 0 0 0.000320720684566658 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Glu342Gln mtrB_p.Glu342Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Glu369Asp mtrB_p.Glu369Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 80.2910622977969 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Glu389Asp mtrB_p.Glu389Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Glu394Gly mtrB_p.Glu394Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 80.2910622977969 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Glu402Leu mtrB_p.Glu402Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Glu429Gly mtrB_p.Glu429Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 8 0 16802 30532 0.000475907198096371 0.00020548462525215 0.000937510381255989 1 0.999879187193184 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 3344 4649 False False Inf 3.10133467016734 Inf 0 0 0.000219525921733526 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 6 0 11496 23707 0.000521648408972352 0.000191459062774625 0.00113506056981396 1 0.999844409142079 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 2778 3890 False False 0 0 0 0 0 0 0 Inf 2.42738974088595 Inf 0 0 0.000320832260499258 1 0.999844409142079 1 6 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Glu460Asp mtrB_p.Glu460Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3280 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Glu460Gly mtrB_p.Glu460Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 11 16810 30521 0 0 0.000219421459229958 0.999639722258614 0.999355455254591 0.999820137367966 0 0 0.284914152918154 NA NA NA 0 0 0.284914152918154 NA NA NA NA 3284 4649 False False 0 0 0.723522114724776 0 0 0.000219421459229958 0.999639722258614 0.999355455254591 0.999820137367966 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 7 11502 23700 0 0 0.000320664925697395 0.999704728561184 0.999391723222185 0.999881277590374 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 2728 3890 False False 0 0 0 0 0 0 0 0 0 1.42986888806462 0 0 0.000320664925697395 0.999704728561184 0.999391723222185 0.999881277590374 2 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Glu460Lys mtrB_p.Glu460Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3299 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2741 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Glu561Ala mtrB_p.Glu561Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Glu561Asp mtrB_p.Glu561Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3300 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2742 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Glu95Ala mtrB_p.Glu95Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3354 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2787 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Glu95Gly mtrB_p.Glu95Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3275 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2723 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Gly122Asp mtrB_p.Gly122Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3281 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2727 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Gly14Ser mtrB_p.Gly14Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Gly174Ala mtrB_p.Gly174Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 24 0 24 37 26 16773 30506 0.00220107079119571 0.00155021590977531 0.00303262250235601 0.999148434429451 0.998752506314373 0.99944365605196 0.587301587301587 0.45617684324957 0.709940357602455 0 0 0.142473597722525 0 0 0.132274604497754 0 0 0.302204589790332 4.24154594223403e-05 44 4649 True False 2.58823016844837 1.52499285039151 4.45309245867462 0 0 0.000219905433549679 0.999148434429451 0.998752506314373 0.99944365605196 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 17 0 17 8 18 11494 23689 0.000695531211963136 0.000300327312744212 0.00137001129783907 0.999240730585902 0.998800291409329 0.999549948712402 0.307692307692307 0.143259997927703 0.517896436445741 0 0 0.195064322969093 0 0 0.185301968137852 0 0 0.499554009981691 0.0014737032997105 52 3890 False False 0 0 0 0 0 0 0 0.915994818552674 0.344521128250468 2.2147544008643 0 0 0.000320888077582845 0.999240730585902 0.998800291409329 0.999549948712402 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Gly385Cys mtrB_p.Gly385Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.75142405620251 0.304356294847217 327.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Gly385Ser mtrB_p.Gly385Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3334 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Gly392Ser mtrB_p.Gly392Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3318 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2755 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Gly392Val mtrB_p.Gly392Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 70.7538526941519 1 1627.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Gly506Asp mtrB_p.Gly506Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 1 9 16809 30523 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999705227302502 0.999440503684993 0.999865202576615 0.1 0.00252857854446178 0.445016117028195 0 0 0.409616397225003 0 0 0.336267116879942 0 0 1.26006308461717 0.0561473188496713 148 4649 False False 0.201763605475902 0.00460699063398853 1.45637661246692 0 0 0.000219434511605659 0.999705227302502 0.999440503684993 0.999865202576615 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 3 11501 23704 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.99987345509765 0.999630227076139 0.999973902638554 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98868218084989 0.555670981350655 466 3890 False False 0 0 0 0 0 0 0 0.687012723531287 0.0130900577164196 8.55773267307823 0 0 0.000320692802708327 0.99987345509765 0.999630227076139 0.999973902638554 2 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Gly506Ser mtrB_p.Gly506Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3328 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2763 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Gly567Ser mtrB_p.Gly567Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Gly90Arg mtrB_p.Gly90Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 70.7603724184383 1 1627.5 4649 False False 0.908144446427509 0.0153974005043644 17.4461131425891 0 0 0.000219434511605659 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.His255Arg mtrB_p.His255Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.His255Asn mtrB_p.His255Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.His324Arg mtrB_p.His324Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.His386Gln mtrB_p.His386Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3301 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2743 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.His386Pro mtrB_p.His386Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3323 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.His521Tyr mtrB_p.His521Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.His562Gln mtrB_p.His562Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3347 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2782 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Ile198Asn mtrB_p.Ile198Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Ile198Thr mtrB_p.Ile198Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Ile247Val mtrB_p.Ile247Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Ile2Thr mtrB_p.Ile2Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3355 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2788 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Ile393Met mtrB_p.Ile393Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Ile78Val mtrB_p.Ile78Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Leu226Val mtrB_p.Leu226Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3316 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2753 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Leu26Val mtrB_p.Leu26Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3286 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2730 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Leu396Arg mtrB_p.Leu396Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 3 3 3 3 16807 30529 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999901742434167 0.999712876815577 0.99997973646933 0.5 0.118117248757025 0.881882751242974 0.5 0.118117248757025 0.881882751242974 0.5 0.118117248757025 0.881882751242974 1.81644552864877 0.243258979140325 13.5672775646283 0.672814146444181 932 4649 False False 1.81644552864877 0.243258979140325 13.5672775646283 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 3 3 3 3 11499 23704 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.99987345509765 0.999630227076139 0.999973902638554 0.5 0.118117248757025 0.881882751242974 0.5 0.118117248757025 0.881882751242974 0.5 0.118117248757025 0.881882751242974 2.06139664318636 0.276050319534324 15.3984166853777 0.39969078412401 359 3890 False False 0 0 0 0 0 0 0 2.06139664318636 0.276050319534324 15.3984166853777 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Leu396Val mtrB_p.Leu396Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Leu40Met mtrB_p.Leu40Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Leu47Ile mtrB_p.Leu47Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3335 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Met260Val mtrB_p.Met260Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 107 16809 30425 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.996495480151971 0.9957666938605 0.997127099240476 0.00925925925925925 0.000234396672809092 0.0505105336567462 NA NA NA 0 0 0.0338879994740114 NA NA NA NA 3349 4649 False True 0.0169162826100614 0.000429252907935397 0.0962956482174168 0 0 0.000219434511605659 0.996495480151971 0.9957666938605 0.997127099240476 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 1 107 11501 23600 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.995486565149534 0.994548542993051 0.996299700717084 0.00925925925925925 0.000234396672809092 0.0505105336567462 NA NA NA 0 0 0.0338879994740114 NA NA NA NA 2784 3890 False True 1 1 1 0 0 0 0 0.0191775278378881 0.000485846567322964 0.109189243334222 0 0 0.000320692802708327 0.995486565149534 0.994548542993051 0.996299700717084 4 5) Not assoc w R New NotAwR yes 5 +Rifampicin mtrB p.Met339Leu mtrB_p.Met339Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3287 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2731 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Met517Leu mtrB_p.Met517Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 14751 25415 2059 5117 0.877513384889946 0.872462192056484 0.882433558123402 0.167594654788418 0.163420492132502 0.171832161994391 0.367250908728775 0.362533909575024 0.371987105579429 NA NA NA 0 0 0.000145135225436261 NA NA NA NA 3329 4649 False True 1.44241562858873 1.36479470140918 1.52478296907879 0 0 0.00178998394889819 0.167594654788418 0.163420492132502 0.171832161994391 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 9872 19355 1630 4352 0.85828551556251 0.851777793719084 0.864611319668296 0.183574471675032 0.178664352794643 0.188562286302203 0.337769870325384 0.332346964626123 0.343225039575074 NA NA NA 0 0 0.000190572355656155 NA NA NA NA 2764 3890 False True 0 1 1 0 0 0 0 1.36179976005312 1.27966086003089 1.44964814999217 0 0 0.00226055731272297 0.183574471675032 0.178664352794643 0.188562286302203 4479 5) Not assoc w R New NotAwR yes 5 +Rifampicin mtrB p.Met530Ile mtrB_p.Met530Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 4.39540875925228 0.556930310247326 910.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 4.98803779447094 0.555669835711629 381 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Met549Ile mtrB_p.Met549Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3332 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2768 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Phe157Ser mtrB_p.Phe157Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3338 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2772 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Phe175Leu mtrB_p.Phe175Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 10 16810 30522 0 0 0.000219421459229958 0.999672474780558 0.999397752220648 0.999842928110511 0 0 0.30849710781876 NA NA NA 0 0 0.30849710781876 NA NA NA NA 3330 4649 False False 0 0 0.81016282812198 0 0 0.000219421459229958 0.999672474780558 0.999397752220648 0.999842928110511 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 2765 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Phe199Cys mtrB_p.Phe199Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Phe292Leu mtrB_p.Phe292Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Pro146Leu mtrB_p.Pro146Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 7 2 16803 30530 0.000416418798334324 0.000167437820935922 0.000857792460925722 0.999934494956111 0.999763393503742 0.99999206693684 0.777777777777777 0.399906426283687 0.971855026522101 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.67462061785852 0.542051660247431 762 4649 False False 6.35928108075938 1.21058944302618 62.7908757790311 0 0 0.000219512858481393 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 5 2 11497 23705 0.00043470700747696 0.000141162766530747 0.00101416710312943 0.999915636731767 0.999695284447545 0.999989783053538 0.714285714285714 0.290420863737342 0.963307433823914 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.9765526229698 1 1214.5 3890 False False 0 0 0 0 0 0 0 5.15460554927372 0.84368657132659 54.1028758865048 0 0 0.000320804359238686 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Pro151Arg mtrB_p.Pro151Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3350 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Pro178Leu mtrB_p.Pro178Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Pro18Leu mtrB_p.Pro18Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3339 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2773 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Pro18Ser mtrB_p.Pro18Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 7279 6107 9531 24425 0.433016061867935 0.425508108159719 0.440547201177567 0.799980348486833 0.795448624306228 0.804454926629809 0.543777080531899 0.535293322623889 0.552241798656402 NA NA NA 0 0 0.000603858778592581 NA NA NA NA 3269 4649 False True 3.05449840176627 2.92974915033392 3.18428873267903 0 0 0.000386965237017854 0.799980348486833 0.795448624306228 0.804454926629809 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 4916 4186 6586 19521 0.427403929751347 0.418339033958165 0.436505588935298 0.823427679588307 0.818513210737051 0.828262726545326 0.540101076686442 0.529795893488989 0.550380579720804 NA NA NA 0 0 0.000880853925828088 NA NA NA NA 2717 3890 False True 0 1 1 0 0 0 0 3.48091152829794 3.31074672078139 3.65956584632278 0 0 0.000559952408022166 0.823427679588307 0.818513210737051 0.828262726545326 1935 5) Not assoc w R New NotAwR yes 5 +Rifampicin mtrB p.Pro200Leu mtrB_p.Pro200Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3297 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Pro529Leu mtrB_p.Pro529Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3319 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Pro534Ser mtrB_p.Pro534Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Pro536Ser mtrB_p.Pro536Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3309 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2748 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Pro548Leu mtrB_p.Pro548Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3303 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Pro548Ser mtrB_p.Pro548Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Pro550Leu mtrB_p.Pro550Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3340 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2774 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Pro551Ser mtrB_p.Pro551Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Pro559Leu mtrB_p.Pro559Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Ser113Ala mtrB_p.Ser113Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3312 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2751 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Ser16Pro mtrB_p.Ser16Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3298 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2740 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Ser16Tyr mtrB_p.Ser16Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Ser176Ala mtrB_p.Ser176Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 5 1 16805 30531 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 0.999967247478055 0.999817528289014 0.999999170778282 0.833333333333333 0.358765421002325 0.99578925548551 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.046581158581538 Inf 0.35502883579441 389 4649 False False 9.08390360011901 1.01631102884943 428.726615606949 5.95025586100202e-05 1.50647321873052e-06 0.000331481949204222 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 4 1 11498 23706 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 0.999957818365883 0.999765001636458 0.999998932054057 0.8 0.28358206388191 0.994949236620532 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0528606181535623 Inf 0.326629740093736 315 3890 False False 0 0 0 0 0 0 0 8.24699947817011 0.815939832795188 405.284913246419 8.69640838333768e-05 2.20173755219544e-06 0.00048443655634461 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Ser176Phe mtrB_p.Ser176Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Ser203Arg mtrB_p.Ser203Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3304 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Ser245Ala mtrB_p.Ser245Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Ser24Arg mtrB_p.Ser24Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Ser24Asn mtrB_p.Ser24Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Ser24Gly mtrB_p.Ser24Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Ser257Pro mtrB_p.Ser257Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3305 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2745 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Ser27Arg mtrB_p.Ser27Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 9 16810 30523 0 0 0.000219421459229958 0.999705227302502 0.999440503684993 0.999865202576615 0 0 0.336267116879942 0 0 0.841886116991581 0 0 0.336267116879942 0 0 9.66838466420259 0.541965918987148 447 4649 False False 0 0 0.920078094923294 0 0 0.000219421459229958 0.999705227302502 0.999440503684993 0.999865202576615 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 9 11502 23698 0 0 0.000320664925697395 0.999620365292951 0.999279457952852 0.99982639261309 0 0 0.336267116879942 0 0 0.841886116991581 0 0 0.336267116879942 0 0 10.9685554882093 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 1.04405446176545 0 0 0.000320664925697395 0.999620365292951 0.999279457952852 0.99982639261309 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Ser283Ala mtrB_p.Ser283Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3277 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Ser283Tyr mtrB_p.Ser283Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3270 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2718 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Ser478Phe mtrB_p.Ser478Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Ser566Arg mtrB_p.Ser566Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Thr169Ala mtrB_p.Thr169Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 4 4 16806 30528 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999868989912223 0.999664596427238 0.999964303043777 0.5 0.157012770487058 0.842987229512941 0 0 0.975 0 0 0.602364635616474 0 0 70.7683587068428 1 1627.5 4649 False False 1.81649410924669 0.338292932357021 9.7540407308173 0 0 0.000219473678051534 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 4 11499 23703 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.999831273463534 0.999568049920357 0.99995402584539 0.428571428571428 0.0989882784425078 0.815948432359917 0 0 0.975 0 0 0.602364635616474 0 0 80.2948602124437 1 1214.5 3890 False False 0 0 0 0 0 0 0 1.54598225932689 0.226418767059518 9.13992940102341 0 0 0.000320748571273651 0.999831273463534 0.999568049920357 0.99995402584539 1 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Thr209Met mtrB_p.Thr209Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Thr20Ile mtrB_p.Thr20Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 9.67028206568003 0.541992006917746 476.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Thr20Lys mtrB_p.Thr20Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Thr336Ala mtrB_p.Thr336Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3313 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Thr336Ile mtrB_p.Thr336Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3351 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2785 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Thr375Ala mtrB_p.Thr375Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Thr376Ala mtrB_p.Thr376Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Thr376Met mtrB_p.Thr376Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Thr46Ile mtrB_p.Thr46Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Thr66Ile mtrB_p.Thr66Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 16 0 16 0 20 16810 30512 0 0 0.000219421459229958 0.999344949561116 0.998988508123428 0.999599833714555 0 0 0.168433470983085 0 0 0.205907214207822 0 0 0.168433470983085 0 0 0.47076013789765 0.00113484601668571 70 4649 False False 0 0 0.367705245397802 0 0 0.000219421459229958 0.999344949561116 0.998988508123428 0.999599833714555 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 16 0 16 0 18 11502 23689 0 0 0.000320664925697395 0.999240730585902 0.998800291409329 0.999549948712402 0 0 0.185301968137852 0 0 0.205907214207822 0 0 0.185301968137852 0 0 0.534154638333336 0.00242381382250299 58 3890 False False 0 0 0 0 0 0 0 0 0 0.468558999031164 0 0 0.000320664925697395 0.999240730585902 0.998800291409329 0.999549948712402 6 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Thr97Lys mtrB_p.Thr97Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3314 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2752 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Trp565Cys mtrB_p.Trp565Cys 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3320 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2756 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Trp565* mtrB_p.Trp565* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Tyr165Asp mtrB_p.Tyr165Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3271 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2719 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Tyr165Cys mtrB_p.Tyr165Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 3 3 16807 30529 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999901742434167 0.999712876815577 0.99997973646933 0.5 0.118117248757025 0.881882751242974 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.39633757793323 0.556924208491887 781 4649 False False 1.81644552864877 0.243258979140325 13.5672775646283 0 0 0.000219460621016169 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 1 11499 23706 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.999957818365883 0.999765001636458 0.999998932054057 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 80.3050096524922 1 1214.5 3890 False False 0 0 0 0 0 0 0 6.18471171406209 0.496496186771195 324.103527365594 0 0 0.000320748571273651 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Val130Met mtrB_p.Val130Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Val147Ile mtrB_p.Val147Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3345 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2779 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Val170Ala mtrB_p.Val170Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3336 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2770 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Val170Leu mtrB_p.Val170Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3352 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Val221Ile mtrB_p.Val221Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3306 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Val224Ala mtrB_p.Val224Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3341 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2775 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Val237Ala mtrB_p.Val237Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Val237Leu mtrB_p.Val237Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3356 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2789 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Val273Leu mtrB_p.Val273Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 8 0 16802 30532 0.000475907198096371 0.00020548462525215 0.000937510381255989 1 0.999879187193184 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 3272 4649 False False Inf 3.10133467016734 Inf 0 0 0.000219525921733526 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 8 0 11494 23707 0.000695531211963136 0.000300327312744212 0.00137001129783907 1 0.999844409142079 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 2720 3890 False False 0 0 0 0 0 0 0 Inf 3.51981666109462 Inf 0 0 0.000320888077582845 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Val273Met mtrB_p.Val273Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Val30Ile mtrB_p.Val30Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Val32Leu mtrB_p.Val32Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3302 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2744 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Val363Met mtrB_p.Val363Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3288 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2732 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Val377Ile mtrB_p.Val377Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 0 10 16810 30522 0 0 0.000219421459229958 0.999672474780558 0.999397752220648 0.999842928110511 0 0 0.30849710781876 0 0 0.369416647552819 0 0 0.30849710781876 0 0 1.06386185129169 0.0571718104508685 179.5 4649 False False 0 0 0.81016282812198 0 0 0.000219421459229958 0.999672474780558 0.999397752220648 0.999842928110511 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 9 11502 23698 0 0 0.000320664925697395 0.999620365292951 0.999279457952852 0.99982639261309 0 0 0.336267116879942 0 0 0.409616397225003 0 0 0.336267116879942 0 0 1.4297388150818 0.104253118616784 129.5 3890 False False 0 0 0 0 0 0 0 0 0 1.04405446176545 0 0 0.000320664925697395 0.999620365292951 0.999279457952852 0.99982639261309 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Val404Ala mtrB_p.Val404Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 13 3 16797 30529 0.000773349196906603 0.000411838091387593 0.00132208760075144 0.999901742434167 0.999712876815577 0.99997973646933 0.8125 0.543543453768388 0.959526266094054 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3307 4649 False False 7.87595007044908 2.16376136698699 43.1042146246268 0 0 0.000219591261323031 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 13 2 11489 23705 0.00113023821944009 0.000601937155487611 0.00193196626494298 0.999915636731767 0.999695284447545 0.999989783053538 0.866666666666666 0.595397303396627 0.983424086559916 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2746 3890 False False 0 0 0 0 0 0 0 13.4113064670554 3.03522611273696 122.566011229554 0 0 0.000321027705298525 0.999915636731767 0.999695284447545 0.999989783053538 1 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Val413Leu mtrB_p.Val413Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3282 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Val489Ala mtrB_p.Val489Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3346 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2780 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Val523Ala mtrB_p.Val523Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3293 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2737 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Val537Asp mtrB_p.Val537Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Val537Ile mtrB_p.Val537Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3321 4649 False False 0.908144446427509 0.0153974005043644 17.4461131425891 0 0 0.000219434511605659 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2757 3890 False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 0 0 0.000320692802708327 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin mtrB p.Val88Ala mtrB_p.Val88Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.-102C>T nusG_c.-102C>T 2 upstream_gene_variant 734152 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4570 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3823 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.-103G>C nusG_c.-103G>C 2 upstream_gene_variant 734151 1 0 0 0 4 23 16806 30509 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999246691995283 0.998869881214224 0.999522409302755 0.148148148148148 0.0418873964737672 0.337310864024244 NA NA NA 0 0 0.148185128915224 NA NA NA NA 4581 4649 False False 0.315715401849236 0.0793669128942507 0.924261287209764 0 0 0.000219473678051534 0.999246691995283 0.998869881214224 0.999522409302755 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 3 20 11499 23687 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.99915636731767 0.998697376967606 0.99948461349205 0.130434782608695 0.0277515074227932 0.335889137537121 NA NA NA 0 0 0.168433470983085 NA NA NA NA 3832 3890 False False 0 0 0 0 0 0 0 0.308987738064179 0.0587922487183818 1.04218833432732 0 0 0.000320748571273651 0.99915636731767 0.998697376967606 0.99948461349205 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.105C>T nusG_c.105C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.-109T>C nusG_c.-109T>C 2 upstream_gene_variant 734145 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.111G>A nusG_c.111G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.-113G>A nusG_c.-113G>A 2 upstream_gene_variant 734141 1 44 2 42 18 51 16792 30481 0.00107079119571683 0.000634738299600123 0.00169178580899694 0.998329621380846 0.997804338187603 0.998756048304117 0.260869565217391 0.162516081307117 0.380596211245703 0.0454545454545454 0.00555295199537049 0.154731577658989 0.0377358490566037 0.00460310927431491 0.129758381663062 0.0864385535062047 0.0101318033770649 0.332346800864789 1.83693292631934e-06 37 4649 True False 0.640662220104811 0.352129851020244 1.11580646005085 0.000119090151244492 1.4422695209485e-05 0.000430127661005664 0.998329621380846 0.997804338187603 0.998756048304117 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 27 2 25 9 32 11493 23675 0.000782472613458529 0.000357856744032263 0.00148485474620048 0.998650187708272 0.998094997333691 0.999076551872477 0.219512195121951 0.10560803322606 0.376137465434002 0.074074074074074 0.00910007294230628 0.242898346845627 0.0588235294117647 0.00720491743904971 0.196773209335575 0.16479596275994 0.0189246502406676 0.661099987388422 0.00341139026967602 62 3890 False False 0 0 0 0 0 0 0 0.579360806577917 0.243154432324621 1.24251610700015 0.000173988690735102 2.10715322043016e-05 0.000628364156401861 0.998650187708272 0.998094997333691 0.999076551872477 6 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.-115C>T nusG_c.-115C>T 2 upstream_gene_variant 734139 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.-121G>C nusG_c.-121G>C 2 upstream_gene_variant 734133 1 4 0 4 1 4 16809 30528 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999868989912223 0.999664596427238 0.999964303043777 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.75158776187525 0.30435761959971 350.5 4649 False False 0.454042477244333 0.00922341562850508 4.58878013974823 0 0 0.000219434511605659 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.-125G>A nusG_c.-125G>A 2 upstream_gene_variant 734129 NA 0 0 0 5 0 16805 30532 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 1 0.999879187193184 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 4603 4649 False False Inf 1.66460481015123 Inf 0 0 0.000219486736640675 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3852 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.-125G>T nusG_c.-125G>T 2 upstream_gene_variant 734129 1 10 0 10 0 11 16810 30521 0 0 0.000219421459229958 0.999639722258614 0.999355455254591 0.999820137367966 0 0 0.284914152918154 0 0 0.30849710781876 0 0 0.284914152918154 0 0 0.810136286654261 0.0177759878309813 117.5 4649 False False 0 0 0.723522114724776 0 0 0.000219421459229958 0.999639722258614 0.999355455254591 0.999820137367966 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 0 11 11502 23696 0 0 0.000320664925697395 0.999536002024718 0.999169931473241 0.999768351851939 0 0 0.284914152918154 0 0 0.30849710781876 0 0 0.284914152918154 0 0 0.919308797237109 0.0366169211476112 108.5 3890 False False 0 0 0 0 0 0 0 0 0 0.821023972766749 0 0 0.000320664925697395 0.999536002024718 0.999169931473241 0.999768351851939 1 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.-126C>T nusG_c.-126C>T 2 upstream_gene_variant 734128 1 1 1 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0465715996825058 Inf 0.355075831185839 416 4649 False False Inf 0.0465715996825058 Inf 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.-127A>C nusG_c.-127A>C 2 upstream_gene_variant 734127 1 3 0 3 14 3 16796 30529 0.000832837596668649 0.000455392489979272 0.00139696554892221 0.999901742434167 0.999712876815577 0.99997973646933 0.823529411764705 0.565682127155716 0.962014931929374 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.39921762524604 0.556905380957875 766 4649 False False 8.48229737239025 2.36670346544812 46.0143904775544 0 0 0.000219604333908644 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 9 2 11493 23705 0.000782472613458529 0.000357856744032263 0.00148485474620048 0.999915636731767 0.999695284447545 0.999989783053538 0.818181818181818 0.482244147639827 0.97716880170004 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.980366167947 1 1214.5 3890 False False 0 0 0 0 0 0 0 9.28151918559122 1.92056817055926 88.3754588820915 0 0 0.000320915993408392 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.-130T>C nusG_c.-130T>C 2 upstream_gene_variant 734124 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.132C>T nusG_c.132C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.-134T>C nusG_c.-134T>C 2 upstream_gene_variant 734120 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.135G>A nusG_c.135G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.-135T>C nusG_c.-135T>C 2 upstream_gene_variant 734119 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.-136C>T nusG_c.-136C>T 2 upstream_gene_variant 734118 0 0 0 0 4 29 16806 30503 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999050176863618 0.998636178123902 0.99936379914753 0.121212121212121 0.0340328814229786 0.28201622853722 NA NA NA 0 0 0.119444869069502 NA NA NA NA 4604 4649 False False 0.250345730383647 0.0639076684546368 0.713095595646224 0 0 0.000219473678051534 0.999050176863618 0.998636178123902 0.99936379914753 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 17 11500 23690 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999282912220019 0.998852120448669 0.999582216212894 0.105263157894736 0.0130121643717774 0.331376664456765 NA NA NA 0 0 0.195064322969093 NA NA NA NA 3853 3890 False False 0 0 0 0 0 0 0 0.24235294117647 0.0271662646620275 1.02125663054826 0 0 0.000320720684566658 0.999282912220019 0.998852120448669 0.999582216212894 4 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.138C>G nusG_c.138C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.138C>T nusG_c.138C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.-138T>C nusG_c.-138T>C 2 upstream_gene_variant 734116 NA 0 0 0 520 3621 16290 26911 0.0309339678762641 0.0283683101921067 0.0336635573886272 0.881403118040089 0.877723853930395 0.885009642418931 0.125573532963052 0.115626868328555 0.136051669619906 NA NA NA 0 0 0.00101822730636326 NA NA NA NA 4629 4649 False True 0.237237626701481 0.215575487592455 0.260714008801128 0 0 0.000226424911678923 0.881403118040089 0.877723853930395 0.885009642418931 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 371 2918 11131 20789 0.0322552599547904 0.0291018294111632 0.0356482362174928 0.876913991648036 0.872664562884071 0.881070779458544 0.112800243235025 0.102184631014815 0.124109635208792 NA NA NA 0 0 0.00126338201890179 NA NA NA NA 3875 3890 False True 0 1 1 0 0 0 0 0.237458674127526 0.212044433138171 0.265298707139019 0 0 0.0003313510253672 0.876913991648036 0.872664562884071 0.881070779458544 422 5) Not assoc w R New NotAwR yes 5 +Rifampicin nusG c.-153C>A nusG_c.-153C>A 2 upstream_gene_variant 734101 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4574 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3825 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 1 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.-158C>G nusG_c.-158C>G 2 upstream_gene_variant 734096 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4626 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3872 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.-15A>G nusG_c.-15A>G 2 upstream_gene_variant 734239 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.15C>T nusG_c.15C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.165C>T nusG_c.165C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.9820231071276 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.24912710990902 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.-170G>A nusG_c.-170G>A 2 upstream_gene_variant 734084 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.-176C>G nusG_c.-176C>G 2 upstream_gene_variant 734078 1 3 1 2 3 2 16807 30530 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999934494956111 0.999763393503742 0.99999206693684 0.6 0.146632799634673 0.947255049473683 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.908252513833521 0.0153992319558821 17.4481890566664 1 1627.5 4649 False False 2.72475754150056 0.312074221533576 32.6324551811023 5.94954783436458e-05 1.50629396217601e-06 0.000331442511213996 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 1 0.025 1 1 0.025 1 Inf 0.0528582512098137 Inf 0.326639588718152 316 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 8.69565217391304e-05 2.20154609696687e-06 0.000484394439799471 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.177G>A nusG_c.177G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.-179T>C nusG_c.-179T>C 2 upstream_gene_variant 734075 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.180C>T nusG_c.180C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.341150751115529 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.-188G>A nusG_c.-188G>A 2 upstream_gene_variant 734066 1 4 0 4 1 4 16809 30528 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999868989912223 0.999664596427238 0.999964303043777 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.75158776187525 0.30435761959971 350.5 4649 False False 0.454042477244333 0.00922341562850508 4.58878013974823 0 0 0.000219434511605659 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 3 11501 23704 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.99987345509765 0.999630227076139 0.999973902638554 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98868218084989 0.555670981350655 466 3890 False False 0 0 0 0 0 0 0 0.687012723531287 0.0130900577164196 8.55773267307823 0 0 0.000320692802708327 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.192C>G nusG_c.192C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.-193C>T nusG_c.-193C>T 2 upstream_gene_variant 734061 NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4588 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.-194C>T nusG_c.-194C>T 2 upstream_gene_variant 734060 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.-197C>A nusG_c.-197C>A 2 upstream_gene_variant 734057 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.-197C>T nusG_c.-197C>T 2 upstream_gene_variant 734057 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.-19A>C nusG_c.-19A>C 2 upstream_gene_variant 734235 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.-1C>T nusG_c.-1C>T 2 upstream_gene_variant 734253 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.-201A>G nusG_c.-201A>G 2 upstream_gene_variant 734053 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.205C>A nusG_c.205C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.207G>T nusG_c.207G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.-20G>C nusG_c.-20G>C 2 upstream_gene_variant 734234 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.213G>A nusG_c.213G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.216C>T nusG_c.216C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.219T>G nusG_c.219T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.222T>C nusG_c.222T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.225C>G nusG_c.225C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.234C>T nusG_c.234C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.237C>T nusG_c.237C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 26 48 16784 30484 0.0015466983938132 0.00101059577405045 0.00226545603351431 0.998427878946679 0.997916129578598 0.998840621560614 0.351351351351351 0.24390463973761 0.471098681493436 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.983804019701302 0.585641274715053 1.61844783984368 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 22 47 11480 23660 0.00191271083289862 0.00119906180010764 0.00289444346770694 0.998017463196524 0.99736450840227 0.998542954015614 0.318840579710144 0.211747858899688 0.442054391447611 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 0 0.964711987545407 0.55337942658253 1.63381506424155 NA NA NA NA NA NA 4 5) Not assoc w R Now listed Silent mutation no 0 +Rifampicin nusG c.246G>A nusG_c.246G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.255C>T nusG_c.255C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.267C>T nusG_c.267C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.-26G>A nusG_c.-26G>A 2 upstream_gene_variant 734228 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.-26G>T nusG_c.-26G>T 2 upstream_gene_variant 734228 1 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4619 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3867 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.279A>G nusG_c.279A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.282C>T nusG_c.282C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.285C>T nusG_c.285C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.288A>G nusG_c.288A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.294G>A nusG_c.294G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.306T>G nusG_c.306T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.309G>A nusG_c.309G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 26 16810 30506 0 0 0.000219421459229958 0.999148434429451 0.998752506314373 0.99944365605196 0 0 0.132274604497754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.276689956335831 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 25 11502 23682 0 0 0.000320664925697395 0.998945459147087 0.998443680572118 0.999317444144018 0 0 0.137185171530712 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.327450166812584 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.-30G>A nusG_c.-30G>A 2 upstream_gene_variant 734224 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4646 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3887 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.315G>A nusG_c.315G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.318C>T nusG_c.318C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.324C>T nusG_c.324C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.327T>C nusG_c.327T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.-33G>A nusG_c.-33G>A 2 upstream_gene_variant 734221 NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4578 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3829 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.33T>C nusG_c.33T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.342C>T nusG_c.342C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.354C>T nusG_c.354C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.-36G>T nusG_c.-36G>T 2 upstream_gene_variant 734218 NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4597 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3847 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.381G>A nusG_c.381G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.381G>T nusG_c.381G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.384G>A nusG_c.384G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 6 2 16804 30530 0.000356930398572278 0.000130998068917797 0.000776724091447791 0.999934494956111 0.999763393503742 0.99999206693684 0.75 0.349144205587175 0.968145973750055 NA NA NA NA NA NA NA NA NA NA NA NA False False 5.4504879790526 0.974471458740784 55.1804345522996 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 4 0 11498 23707 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 1 0.999844409142079 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.3608069907404 Inf NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.-38C>A nusG_c.-38C>A 2 upstream_gene_variant 734216 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4579 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3830 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.-38C>G nusG_c.-38C>G 2 upstream_gene_variant 734216 1 6 0 6 0 6 16810 30526 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.54251408011679 0.0957784996510068 197 4649 False False 0 0 1.54251408011679 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12235036001139 0.310791984491028 261 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.390G>T nusG_c.390G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.396C>T nusG_c.396C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.402G>A nusG_c.402G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.402G>C nusG_c.402G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.405A>G nusG_c.405A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 202 599 16608 29933 0.0120166567519333 0.0104246250589301 0.0137806979802955 0.98038123935543 0.978762740451512 0.981907401449957 0.252184769038701 0.222444642022555 0.283761214254313 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.60779546675416 0.515029632551636 0.714904320669439 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 124 519 11378 23188 0.0107807337854286 0.00897462517736371 0.0128404426969541 0.978107731893533 0.976164232073162 0.979932754846831 0.192846034214618 0.163041296787573 0.225501662413906 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 0 0.486913358470577 0.396493555990556 0.594204631255598 NA NA NA NA NA NA 74 5) Not assoc w R Now listed Silent mutation no 0 +Rifampicin nusG c.408A>G nusG_c.408A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.-40T>C nusG_c.-40T>C 2 upstream_gene_variant 734214 NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4584 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3835 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.417G>C nusG_c.417G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.-41G>T nusG_c.-41G>T 2 upstream_gene_variant 734213 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4630 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3876 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.426C>G nusG_c.426C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.429C>A nusG_c.429C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.432C>T nusG_c.432C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.435C>T nusG_c.435C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.438C>T nusG_c.438C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.441G>A nusG_c.441G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.444G>C nusG_c.444G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.447G>A nusG_c.447G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.-44G>A nusG_c.-44G>A 2 upstream_gene_variant 734210 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4624 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3871 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.451C>T nusG_c.451C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.465G>A nusG_c.465G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.468G>A nusG_c.468G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.483C>T nusG_c.483C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.495C>T nusG_c.495C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.504T>G nusG_c.504T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 16 16808 30516 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999475959648893 0.999149130429312 0.999700436936355 0.111111111111111 0.0137512156643644 0.347120438608672 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.226945502141837 0.0253113761500421 0.965480715487769 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 11 11501 23696 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999536002024718 0.999169931473241 0.999768351851939 0.0833333333333333 0.00210759323186022 0.384796165150944 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.187303870809652 0.00435512240392776 1.28902134064421 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.507C>T nusG_c.507C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.522C>T nusG_c.522C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.-52G>C nusG_c.-52G>C 2 upstream_gene_variant 734202 1 17 0 17 5 29 16805 30503 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 0.999050176863618 0.998636178123902 0.99936379914753 0.147058823529411 0.0495284552561774 0.310565730395125 0 0 0.195064322969093 0 0 0.119444869069502 0 0 0.43995041644853 0.000679442157120357 64 4649 True False 0.312950784351947 0.0945671276130286 0.817868751719111 0 0 0.000219486736640675 0.999050176863618 0.998636178123902 0.99936379914753 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 17 0 17 5 28 11497 23679 0.00043470700747696 0.000141162766530747 0.00101416710312943 0.998818914244737 0.998293451150132 0.999215038088353 0.151515151515151 0.0510886993560812 0.318989819710436 0 0 0.195064322969093 0 0 0.123436118500263 0 0 0.499209271367254 0.0014705494652198 50 3890 False False 0 0 0 0 0 0 0 0.367782278606841 0.110865900929242 0.965099097196106 0 0 0.000320804359238686 0.998818914244737 0.998293451150132 0.999215038088353 2 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.546G>A nusG_c.546G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.564C>A nusG_c.564C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.564C>T nusG_c.564C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 10 3 16800 30529 0.000594883997620464 0.000285305684944214 0.00109373983334496 0.999901742434167 0.999712876815577 0.99997973646933 0.769230769230769 0.461868460765959 0.949618926508848 NA NA NA NA NA NA NA NA NA NA NA NA False False 6.05734126984126 1.55931702668942 34.2318335698778 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 4 3 11498 23704 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 0.99987345509765 0.999630227076139 0.999973902638554 0.571428571428571 0.184051567640083 0.901011721557492 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.74876790166405 0.464911430750807 18.766829223129 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.567A>G nusG_c.567A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.576C>G nusG_c.576C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.576C>T nusG_c.576C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.585C>T nusG_c.585C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.-59C>T nusG_c.-59C>T 2 upstream_gene_variant 734195 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.600A>T nusG_c.600A>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.609C>T nusG_c.609C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.-64C>T nusG_c.-64C>T 2 upstream_gene_variant 734190 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.652C>T nusG_c.652C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.-65C>T nusG_c.-65C>T 2 upstream_gene_variant 734189 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.678A>C nusG_c.678A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.341150751115529 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.681G>A nusG_c.681G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.681G>T nusG_c.681G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.-68G>C nusG_c.-68G>C 2 upstream_gene_variant 734186 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4613 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3861 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.705C>T nusG_c.705C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.-70T>C nusG_c.-70T>C 2 upstream_gene_variant 734184 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.711G>A nusG_c.711G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.-74T>G nusG_c.-74T>G 2 upstream_gene_variant 734180 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4598 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.75A>C nusG_c.75A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 11 0 16799 30532 0.00065437239738251 0.000326704163498642 0.00117055062018267 1 0.999879187193184 1 1 0.715085847081845 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 4.56066720991606 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 11 0 11491 23707 0.000956355416449313 0.000477502787107626 0.00171053820723243 1 0.999844409142079 1 1 0.715085847081845 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 5.1761760609822 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.81C>G nusG_c.81C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.-82G>T nusG_c.-82G>T 2 upstream_gene_variant 734172 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4641 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3884 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.84G>T nusG_c.84G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin nusG c.-85G>C nusG_c.-85G>C 2 upstream_gene_variant 734169 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.-88C>T nusG_c.-88C>T 2 upstream_gene_variant 734166 1 3 0 3 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 4.39540875925228 0.556930310247326 910.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.-90C>A nusG_c.-90C>A 2 upstream_gene_variant 734164 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.-90C>T nusG_c.-90C>T 2 upstream_gene_variant 734164 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.-92G>A nusG_c.-92G>A 2 upstream_gene_variant 734162 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4585 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3836 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.-92G>T nusG_c.-92G>T 2 upstream_gene_variant 734162 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4571 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3824 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.-97A>G nusG_c.-97A>G 2 upstream_gene_variant 734157 1 6 0 6 0 7 16810 30525 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 1.54246355322091 0.0957757853990922 188.5 4649 False False 0 0 1.26007067420399 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 7 11502 23700 0 0 0.000320664925697395 0.999704728561184 0.999391723222185 0.999881277590374 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 1.75031247356753 0.186841449254093 219 3890 False False 0 0 0 0 0 0 0 0 0 1.42986888806462 0 0 0.000320664925697395 0.999704728561184 0.999391723222185 0.999881277590374 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG c.-98C>T nusG_c.-98C>T 2 upstream_gene_variant 734156 1 1 0 1 26 2 16784 30530 0.0015466983938132 0.00101059577405045 0.00226545603351431 0.999934494956111 0.999763393503742 0.99999206693684 0.928571428571428 0.764965226825409 0.991229503296472 0 0 0.975 0 0 0.841886116991581 0 0 70.8656542659822 1 1627.5 4649 False False 23.6469256434699 5.91851047256808 204.92949269522 0 0 0.000219761326426665 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 19 1 11483 23706 0.00165188662841245 0.000994827479836083 0.00257842889005257 0.999957818365883 0.999765001636458 0.999998932054057 0.95 0.751267237227972 0.99873491050205 0 0 0.975 0 0 0.975 0 0 80.4167631739764 1 1214.5 3890 False False 0 0 0 0 0 0 0 39.224418705913 6.23273860608266 1616.87213437659 0 0 0.000321195419037164 0.999957818365883 0.999765001636458 0.999998932054057 5 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Ala10Val nusG_p.Ala10Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0465715996825058 Inf 0.355075831185839 416 4649 False False Inf 0.0465715996825058 Inf 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0528490600080728 Inf 0.32667783805277 340.5 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Ala122Glu nusG_p.Ala122Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 4631 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 0 0 0.000219447565534303 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3877 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Ala122Val nusG_p.Ala122Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4635 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3880 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Ala135Val nusG_p.Ala135Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Ala141Val nusG_p.Ala141Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4614 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3862 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Ala143Val nusG_p.Ala143Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Ala161Pro nusG_p.Ala161Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4647 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3888 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Ala161Thr nusG_p.Ala161Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 16809 30529 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999901742434167 0.999712876815577 0.99997973646933 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.39581433818102 0.556927644280045 795 4649 False False 0.605409800305391 0.0115361654751757 7.54087213596152 0 0 0.000219434511605659 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.9727417274169 1 1214.5 3890 False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 0 0 0.000320692802708327 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Ala161Val nusG_p.Ala161Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 19 0 19 4 28 16806 30504 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999082929385562 0.99867484826652 0.999390529439302 0.125 0.0351306531033114 0.289948420190755 0 0 0.176466911806965 0 0 0.123436118500263 0 0 0.388982070886363 0.000378216287286621 60 4649 True False 0.259295149691436 0.0661059792882359 0.741375811150309 0 0 0.000219473678051534 0.999082929385562 0.99867484826652 0.999390529439302 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 15 0 15 2 22 11500 23685 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999072004049436 0.998595338091004 0.999418341378366 0.0833333333333333 0.0102563412812501 0.269972801557603 0 0 0.218019360910534 0 0 0.154372512815574 0 0 0.574357431419321 0.00414146881934518 64 3890 False False 0 0 0 0 0 0 0 0.187233201581027 0.0213407665977389 0.761893409393294 0 0 0.000320720684566658 0.999072004049436 0.998595338091004 0.999418341378366 3 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Ala165Gly nusG_p.Ala165Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4575 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3826 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Ala169Val nusG_p.Ala169Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 8 16810 30524 0 0 0.000219421459229958 0.999737979824446 0.999483781433772 0.999886871715824 0 0 0.369416647552819 0 0 0.841886116991581 0 0 0.369416647552819 0 0 9.66870089788069 0.541970266872076 448 4649 False False 0 0 1.06393155676265 0 0 0.000219421459229958 0.999737979824446 0.999483781433772 0.999886871715824 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 7 11502 23700 0 0 0.000320664925697395 0.999704728561184 0.999391723222185 0.999881277590374 0 0 0.409616397225003 0 0 0.841886116991581 0 0 0.409616397225003 0 0 10.9694794681607 1 504 3890 False False 0 0 0 0 0 0 0 0 0 1.42986888806462 0 0 0.000320664925697395 0.999704728561184 0.999391723222185 0.999881277590374 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Ala170Thr nusG_p.Ala170Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Ala171Val nusG_p.Ala171Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4599 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3848 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Ala210Thr nusG_p.Ala210Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 8 16810 30524 0 0 0.000219421459229958 0.999737979824446 0.999483781433772 0.999886871715824 0 0 0.369416647552819 0 0 0.707598226178713 0 0 0.369416647552819 0 0 4.39483273622525 0.556934100285311 925 4649 False False 0 0 1.06393155676265 0 0 0.000219421459229958 0.999737979824446 0.999483781433772 0.999886871715824 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 8 11502 23699 0 0 0.000320664925697395 0.999662546927068 0.999335191784523 0.999854300817065 0 0 0.369416647552819 0 0 0.707598226178713 0 0 0.369416647552819 0 0 4.9871958208267 0.555668343749569 372 3890 False False 0 0 0 0 0 0 0 0 0 1.20731769892417 0 0 0.000320664925697395 0.999662546927068 0.999335191784523 0.999854300817065 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Ala21Thr nusG_p.Ala21Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 11 0 11 0 12 16810 30520 0 0 0.000219421459229958 0.999606969736669 0.999313555980458 0.999796899563454 0 0 0.264648469397051 0 0 0.284914152918154 0 0 0.264648469397051 0 0 0.723498419646924 0.0103093117636392 103.5 4649 False False 0 0 0.653527260731835 0 0 0.000219421459229958 0.999606969736669 0.999313555980458 0.999796899563454 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 0 11 0 12 11502 23695 0 0 0.000320664925697395 0.999493820390602 0.999115973206486 0.999738423129043 0 0 0.264648469397051 0 0 0.284914152918154 0 0 0.264648469397051 0 0 0.820989328158932 0.0205737298546489 89 3890 False False 0 0 0 0 0 0 0 0 0 0.741560034978285 0 0 0.000320664925697395 0.999493820390602 0.999115973206486 0.999738423129043 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Ala26Glu nusG_p.Ala26Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Ala26Thr nusG_p.Ala26Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 11 0 11 0 12 16810 30520 0 0 0.000219421459229958 0.999606969736669 0.999313555980458 0.999796899563454 0 0 0.264648469397051 0 0 0.284914152918154 0 0 0.264648469397051 0 0 0.723498419646924 0.0103093117636392 103.5 4649 False False 0 0 0.653527260731835 0 0 0.000219421459229958 0.999606969736669 0.999313555980458 0.999796899563454 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 0 11 0 11 11502 23696 0 0 0.000320664925697395 0.999536002024718 0.999169931473241 0.999768351851939 0 0 0.284914152918154 0 0 0.284914152918154 0 0 0.284914152918154 0 0 0.821023972766749 0.0205742005406294 90 3890 False False 0 0 0 0 0 0 0 0 0 0.821023972766749 0 0 0.000320664925697395 0.999536002024718 0.999169931473241 0.999768351851939 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Ala36Ser nusG_p.Ala36Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Ala36Val nusG_p.Ala36Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4620 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3868 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Ala40Gly nusG_p.Ala40Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4623 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3870 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Ala40Thr nusG_p.Ala40Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Ala56Val nusG_p.Ala56Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 9 4 16801 30528 0.000535395597858417 0.000244845253515427 0.00101610321951737 0.999868989912223 0.999664596427238 0.999964303043777 0.692307692307692 0.385738338249294 0.909079605427903 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.75289810908392 0.304368279620441 365.5 4649 False False 4.08832807570977 1.14079815739485 18.1636973211369 0 0 0.000219538986540545 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 5 4 11497 23703 0.00043470700747696 0.000141162766530747 0.00101416710312943 0.999831273463534 0.999568049920357 0.99995402584539 0.555555555555555 0.212008506778868 0.863004337734833 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12370862385889 0.310826332578155 297 3890 False False 0 0 0 0 0 0 0 2.57708532660694 0.554584695645254 12.9917397554896 0 0 0.000320804359238686 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Ala64Val nusG_p.Ala64Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 16810 30526 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.54251408011679 0.0957784996510068 197 4649 False False 0 0 1.54251408011679 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Arg124Cys nusG_p.Arg124Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4607 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3856 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Arg124His nusG_p.Arg124His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4576 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3827 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Arg124Leu nusG_p.Arg124Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 35 0 16775 30532 0.00208209399167162 0.00145067008444318 0.00289451049645224 1 0.999879187193184 1 1 0.899967564427894 1 NA NA NA NA NA NA NA NA NA NA 4586 4649 False False Inf 16.3709230324347 Inf 0 0 0.000219879218198805 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 22 0 11480 23707 0.00191271083289862 0.00119906180010764 0.00289444346770694 1 0.999844409142079 1 1 0.845627487184425 1 NA NA NA NA NA NA NA NA NA NA 3837 3890 False False 0 0 0 0 0 0 0 Inf 11.3088830935203 Inf 0 0 0.000321279341637369 1 0.999844409142079 1 4 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Arg124Ser nusG_p.Arg124Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4615 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3863 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Arg138Cys nusG_p.Arg138Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Arg154Gln nusG_p.Arg154Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Arg154Pro nusG_p.Arg154Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Arg154Trp nusG_p.Arg154Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Arg178His nusG_p.Arg178His 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Arg69Gln nusG_p.Arg69Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4608 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Arg69Leu nusG_p.Arg69Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4589 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3840 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Arg69Trp nusG_p.Arg69Trp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 17 0 16793 30532 0.00101130279595478 0.000589228022589122 0.0016187015795436 1 0.999879187193184 1 1 0.804935677030906 1 NA NA NA NA NA NA NA NA NA NA 4612 4649 False False Inf 7.50125453808733 Inf 0 0 0.000219643561005912 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 6 0 11496 23707 0.000521648408972352 0.000191459062774625 0.00113506056981396 1 0.999844409142079 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 3860 3890 False False 0 0 0 0 0 0 0 Inf 2.42738974088595 Inf 0 0 0.000320832260499258 1 0.999844409142079 1 2 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Arg97Cys nusG_p.Arg97Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4595 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3845 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Asn101Ser nusG_p.Asn101Ser 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 10 32 16800 30500 0.000594883997620464 0.000285305684944214 0.00109373983334496 0.998951919297786 0.998520742016693 0.999283006561325 0.238095238095238 0.120516186492179 0.394502429021575 NA NA NA 0 0 0.108881160679352 NA NA NA NA 4580 4649 False False 0.567336309523809 0.24873649736883 1.18322413685267 0 0 0.000219552052902727 0.998951919297786 0.998520742016693 0.999283006561325 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 17 11501 23690 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999282912220019 0.998852120448669 0.999582216212894 0.0555555555555555 0.00140555616736942 0.272943599673368 NA NA NA 0 0 0.195064322969093 NA NA NA NA 3831 3890 False False 0 0 0 0 0 0 0 0.121165934420024 0.00290305390139272 0.77349141370224 0 0 0.000320692802708327 0.999282912220019 0.998852120448669 0.999582216212894 14 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Asn125Ser nusG_p.Asn125Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4587 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3838 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Asn20Lys nusG_p.Asn20Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Asn65Asp nusG_p.Asn65Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4616 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3864 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Asn65His nusG_p.Asn65His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 23 0 16787 30532 0.00136823319452706 0.000867533996903047 0.00205231857920666 1 0.999879187193184 1 1 0.851814871084775 1 NA NA NA NA NA NA NA NA NA NA 4617 4649 False False Inf 10.4516780546009 Inf 0 0 0.000219722057257406 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 13 0 11489 23707 0.00113023821944009 0.000601937155487611 0.00193196626494298 1 0.999844409142079 1 1 0.752947361999529 1 NA NA NA NA NA NA NA NA NA NA 3865 3890 False False 0 0 0 0 0 0 0 Inf 6.28688570681876 Inf 0 0 0.000321027705298525 1 0.999844409142079 1 2 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Asn65Ser nusG_p.Asn65Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 4600 4649 False False Inf 1.1990579265185 Inf 0 0 0.000219473678051534 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3849 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 5 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Asn65Tyr nusG_p.Asn65Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4572 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Asn72His nusG_p.Asn72His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4567 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3820 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Asn72Tyr nusG_p.Asn72Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4582 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3833 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Asp118Tyr nusG_p.Asp118Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4636 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Asp195Asn nusG_p.Asp195Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4605 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3854 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Asp48Ala nusG_p.Asp48Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4639 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Asp77Ala nusG_p.Asp77Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4632 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3878 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Gln213Arg nusG_p.Gln213Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Gln23Lys nusG_p.Gln23Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Gln71Pro nusG_p.Gln71Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4601 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3850 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Glu177Gly nusG_p.Glu177Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.75142405620251 0.304356294847217 327.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Glu177Lys nusG_p.Glu177Lys 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4648 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3889 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Glu182Ala nusG_p.Glu182Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Glu186Ala nusG_p.Glu186Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 6 1 16804 30531 0.000356930398572278 0.000130998068917797 0.000776724091447791 0.999967247478055 0.999817528289014 0.999999170778282 0.857142857142857 0.421276802956804 0.996389703138099 0 0 0.975 0 0 0.975 0 0 70.7837195358556 1 1627.5 4649 False False 10.9013330159485 1.32231137693091 500.206066508325 0 0 0.000219499796783869 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 5 1 11497 23706 0.00043470700747696 0.000141162766530747 0.00101416710312943 0.999957818365883 0.999765001636458 0.999998932054057 0.833333333333333 0.358765421002325 0.99578925548551 0 0 0.975 0 0 0.975 0 0 80.3189618536173 1 1214.5 3890 False False 0 0 0 0 0 0 0 10.3096459946072 1.15337945963023 486.419600220716 0 0 0.000320804359238686 0.999957818365883 0.999765001636458 0.999998932054057 3 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Glu186Asp nusG_p.Glu186Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4644 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Glu18Gly nusG_p.Glu18Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Glu229Lys nusG_p.Glu229Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4645 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Glu67Gln nusG_p.Glu67Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4590 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3841 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Glu87Asp nusG_p.Glu87Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4591 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Gly155Arg nusG_p.Gly155Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4592 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3842 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Gly174Ser nusG_p.Gly174Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Gly175Arg nusG_p.Gly175Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4606 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3855 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Gly76_Asp77del nusG_p.Gly76_Asp77del 2 inframe_deletion (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4609 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3857 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Gly76Asp nusG_p.Gly76Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Ile205Val nusG_p.Ile205Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Leu73Phe nusG_p.Leu73Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 8 0 16802 30532 0.000475907198096371 0.00020548462525215 0.000937510381255989 1 0.999879187193184 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 4593 4649 False False Inf 3.10133467016734 Inf 0 0 0.000219525921733526 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 6 0 11496 23707 0.000521648408972352 0.000191459062774625 0.00113506056981396 1 0.999844409142079 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 3843 3890 False False 0 0 0 0 0 0 0 Inf 2.42738974088595 Inf 0 0 0.000320832260499258 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Leu73Pro nusG_p.Leu73Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 5 0 16805 30532 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 1 0.999879187193184 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 4596 4649 False False Inf 1.66460481015123 Inf 0 0 0.000219486736640675 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3846 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Lys162Asn nusG_p.Lys162Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Lys93Thr nusG_p.Lys93Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Lys98Thr nusG_p.Lys98Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4633 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Met194Ile nusG_p.Met194Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4573 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Met194Thr nusG_p.Met194Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3839 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Phe150Leu nusG_p.Phe150Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Phe232Cys nusG_p.Phe232Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 2 3 16808 30529 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999901742434167 0.999712876815577 0.99997973646933 0.4 0.0527449505263169 0.853367200365326 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.39607594248311 0.556925925901691 785 4649 False False 1.21089163890211 0.101157890363798 10.5697741171107 0 0 0.000219447565534303 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 3 11501 23704 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.99987345509765 0.999630227076139 0.999973902638554 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98868218084989 0.555670981350655 466 3890 False False 0 0 0 0 0 0 0 0.687012723531287 0.0130900577164196 8.55773267307823 0 0 0.000320692802708327 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Phe4Ser nusG_p.Phe4Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 10 0 10 6 11 16804 30521 0.000356930398572278 0.000130998068917797 0.000776724091447791 0.999639722258614 0.999355455254591 0.999820137367966 0.352941176470588 0.14209748311022 0.616716336556597 0 0 0.30849710781876 0 0 0.284914152918154 0 0 0.810425575790437 0.0177830651943001 123 4649 False False 0.990705676137716 0.30078364952977 2.92317510201488 0 0 0.000219499796783869 0.999639722258614 0.999355455254591 0.999820137367966 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 6 10 11496 23697 0.000521648408972352 0.000191459062774625 0.00113506056981396 0.999578183658835 0.999224402000993 0.999797704727851 0.375 0.151983675081122 0.645653905697921 0 0 0.336267116879942 0 0 0.30849710781876 0 0 1.04455536316238 0.0357582540323652 103 3890 False False 0 0 0 0 0 0 0 1.23679540709812 0.369335124594985 3.75660448725682 0 0 0.000320832260499258 0.999578183658835 0.999224402000993 0.999797704727851 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Pro202Leu nusG_p.Pro202Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Pro28Leu nusG_p.Pro28Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4602 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3851 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Pro28Ser nusG_p.Pro28Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Pro28Thr nusG_p.Pro28Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Pro34Leu nusG_p.Pro34Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 26 246 16784 30286 0.0015466983938132 0.00101059577405045 0.00226545603351431 0.991942879601729 0.990875491003099 0.992915002143924 0.0955882352941176 0.0633951194510223 0.136918530256676 NA NA NA 0 0 0.0148835731382165 NA NA NA NA 4618 4649 False True 0.190714927883311 0.122097154112147 0.286424212728764 0 0 0.000219761326426665 0.991942879601729 0.990875491003099 0.992915002143924 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 24 230 11478 23477 0.00208659363588941 0.001337363263423 0.00310310526233451 0.990298224153203 0.988967437079767 0.991506641770207 0.0944881889763779 0.061481892549087 0.137325779698959 NA NA NA 0 0 0.0159106727477668 NA NA NA NA 3866 3890 False True 0 1 1 0 0 0 0 0.213432123457351 0.133917616782314 0.325837930393614 0 0 0.000321335314405605 0.990298224153203 0.988967437079767 0.991506641770207 14 5) Not assoc w R New NotAwR yes 5 +Rifampicin nusG p.Ser156Leu nusG_p.Ser156Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Ser190Pro nusG_p.Ser190Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4577 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3828 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Ser206Gly nusG_p.Ser206Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 2 16808 30530 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999934494956111 0.999763393503742 0.99999206693684 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 70.7645776857468 1 1627.5 4649 False False 1.8163969538315 0.131636449523742 25.0652602654423 0 0 0.000219447565534303 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 80.2876797383181 1 1214.5 3890 False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 0 0 0.000320692802708327 0.999915636731767 0.999695284447545 0.999989783053538 1 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Ser236Ala nusG_p.Ser236Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 0 8 16810 30524 0 0 0.000219421459229958 0.999737979824446 0.999483781433772 0.999886871715824 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 1.06393155676265 0.057171463062894 176 4649 False False 0 0 1.06393155676265 0 0 0.000219421459229958 0.999737979824446 0.999483781433772 0.999886871715824 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 0 8 11502 23699 0 0 0.000320664925697395 0.999662546927068 0.999335191784523 0.999854300817065 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 1.20731769892417 0.0599154010311281 117.5 3890 False False 0 0 0 0 0 0 0 0 0 1.20731769892417 0 0 0.000320664925697395 0.999662546927068 0.999335191784523 0.999854300817065 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Ser236Tyr nusG_p.Ser236Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Ser44Arg nusG_p.Ser44Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 16810 30526 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.54251408011679 0.0957784996510068 197 4649 False False 0 0 1.54251408011679 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Ser9Phe nusG_p.Ser9Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4610 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3858 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Thr116Asn nusG_p.Thr116Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4637 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3881 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Thr126Ala nusG_p.Thr126Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 4611 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 0 0 0.000219447565534303 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3859 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Thr136Ile nusG_p.Thr136Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4568 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3821 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Thr167Ala nusG_p.Thr167Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Thr167Met nusG_p.Thr167Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 18 147 16792 30385 0.00107079119571683 0.000634738299600123 0.00169178580899694 0.995185379274204 0.994343522585473 0.995930762443103 0.109090909090909 0.0659490941799818 0.166923996860761 NA NA NA 0 0 0.0247821704895807 NA NA NA NA 4628 4649 False True 0.221570524350759 0.12774547529171 0.362712751920558 0 0 0.000219656639819404 0.995185379274204 0.994343522585473 0.995930762443103 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 17 135 11485 23572 0.00147800382542166 0.000861220016155565 0.00236537605429428 0.994305479394271 0.993263373209886 0.995223416269876 0.111842105263157 0.0665179194302587 0.173023784491057 NA NA NA 0 0 0.0269550815831828 NA NA NA NA 3874 3890 False True 0 1 1 0 0 0 0 0.2584524097454 0.146209133545038 0.429677140319383 0 0 0.000321139494990277 0.994305479394271 0.993263373209886 0.995223416269876 9 5) Not assoc w R New NotAwR yes 5 +Rifampicin nusG p.Thr192Ile nusG_p.Thr192Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Thr200Ala nusG_p.Thr200Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 19 0 19 0 20 16810 30512 0 0 0.000219421459229958 0.999344949561116 0.998988508123428 0.999599833714555 0 0 0.168433470983085 0 0 0.176466911806965 0 0 0.168433470983085 0 0 0.388991487101318 0.000378227438949618 61 4649 True False 0 0 0.367705245397802 0 0 0.000219421459229958 0.999344949561116 0.998988508123428 0.999599833714555 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 18 0 18 0 19 11502 23688 0 0 0.000320664925697395 0.999198548951786 0.998748716594888 0.999517407326546 0 0 0.176466911806965 0 0 0.185301968137852 0 0 0.176466911806965 0 0 0.468539227868106 0.00149075665530164 55 3890 False False 0 0 0 0 0 0 0 0 0 0.441417616308252 0 0 0.000320664925697395 0.999198548951786 0.998748716594888 0.999517407326546 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Thr3Asn nusG_p.Thr3Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 51 16810 30481 0 0 0.000219421459229958 0.998329621380846 0.997804338187603 0.998756048304117 0 0 0.0697770307495386 NA NA NA 0 0 0.0697770307495386 NA NA NA NA 4642 4649 False True 0 0 0.136027593304398 0 0 0.000219421459229958 0.998329621380846 0.997804338187603 0.998756048304117 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 46 11502 23661 0 0 0.000320664925697395 0.99805964483064 0.997412676641639 0.99857907669397 0 0 0.0770618270519006 NA NA NA 0 0 0.0770618270519006 NA NA NA NA 3885 3890 False True 1 1 1 0 0 0 0 0 0 0.17180687871604 0 0 0.000320664925697395 0.99805964483064 0.997412676641639 0.99857907669397 3 5) Not assoc w R New NotAwR yes 5 +Rifampicin nusG p.Thr8Arg nusG_p.Thr8Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4625 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Thr8Met nusG_p.Thr8Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Trp120Cys nusG_p.Trp120Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4634 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3879 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Val100Ala nusG_p.Val100Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Val181Ile nusG_p.Val181Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4640 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3883 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Val187Gly nusG_p.Val187Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4643 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3886 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Val187Leu nusG_p.Val187Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 0 9 16810 30523 0 0 0.000219421459229958 0.999705227302502 0.999440503684993 0.999865202576615 0 0 0.336267116879942 0 0 0.369416647552819 0 0 0.336267116879942 0 0 1.06389670402746 0.0571716365180711 178 4649 False False 0 0 0.920078094923294 0 0 0.000219421459229958 0.999705227302502 0.999440503684993 0.999865202576615 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 6 11502 23701 0 0 0.000320664925697395 0.9997469101953 0.999449212060655 0.99990711502044 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 2.24903207808669 0.180419790287488 167.5 3890 False False 0 0 0 0 0 0 0 0 0 1.75038628279554 0 0 0.000320664925697395 0.9997469101953 0.999449212060655 0.99990711502044 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Val193Ile nusG_p.Val193Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Val217Ala nusG_p.Val217Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4569 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3822 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Val70Ala nusG_p.Val70Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 16 0 16794 30532 0.000951814396192742 0.000544138942285324 0.00154522796648703 1 0.999879187193184 1 1 0.794092785792177 1 NA NA NA NA NA NA NA NA NA NA 4638 4649 False False Inf 7.00986495552168 Inf 0 0 0.000219630483749807 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 8 0 11494 23707 0.000695531211963136 0.000300327312744212 0.00137001129783907 1 0.999844409142079 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 3882 3890 False False 0 0 0 0 0 0 0 Inf 3.51981666109462 Inf 0 0 0.000320888077582845 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Val70Leu nusG_p.Val70Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4621 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Val70Met nusG_p.Val70Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4627 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3873 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Val75Ala nusG_p.Val75Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4622 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3869 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Val75Gly nusG_p.Val75Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 8 0 16802 30532 0.000475907198096371 0.00020548462525215 0.000937510381255989 1 0.999879187193184 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 4594 4649 False False Inf 3.10133467016734 Inf 0 0 0.000219525921733526 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 11498 23707 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 1 0.999844409142079 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3844 3890 False False 0 0 0 0 0 0 0 Inf 1.3608069907404 Inf 0 0 0.000320776462830572 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin nusG p.Val82Ile nusG_p.Val82Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4583 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3834 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.1002C>T rpoA_c.1002C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.75142405620251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-102_-97delTCGGGGinsC rpoA_c.-102_-97delTCGGGGinsC 2 upstream_gene_variant 3878604 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.1023C>T rpoA_c.1023C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 23 16809 30509 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999246691995283 0.998869881214224 0.999522409302755 0.0416666666666666 0.00105435244546974 0.211201683456973 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.0789147635712752 0.00191977076020803 0.486056680807954 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 23 11501 23684 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.99902982241532 0.998544610722761 0.99938489435488 0.0416666666666666 0.00105435244546974 0.211201683456973 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.0895347474510723 0.00217743413029611 0.551561418572831 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.1026C>T rpoA_c.1026C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.1044G>A rpoA_c.1044G>A 2 stop_retained_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.108T>C rpoA_c.108T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-113_-107delCAACCCA rpoA_c.-113_-107delCAACCCA 2 upstream_gene_variant 3878613 1 1 0 1 0 7 16810 30525 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 0 0 0.409616397225003 0 0 0.975 0 0 0.409616397225003 0 0 70.7445928654589 1 1627.5 4649 False False 0 0 1.26007067420399 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 7 11502 23700 0 0 0.000320664925697395 0.999704728561184 0.999391723222185 0.999881277590374 0 0 0.409616397225003 0 0 0.975 0 0 0.409616397225003 0 0 80.2637968349099 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 1.42986888806462 0 0 0.000320664925697395 0.999704728561184 0.999391723222185 0.999881277590374 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.-113_-74delCAACCCAACCCTCGGGGGGCGCCGCCCCCCGAGTACCCCC rpoA_c.-113_-74delCAACCCAACCCTCGGGGGGCGCCGCCCCCCGAGTACCCCC 2 upstream_gene_variant 3878580 1 3 1 2 3 3 16807 30529 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999901742434167 0.999712876815577 0.99997973646933 0.5 0.118117248757025 0.881882751242974 0.333333333333333 0.00840375865961264 0.905700675949754 0.25 0.00630946320970987 0.805879550316756 0.908222764324388 0.0153987277522295 17.447617625427 1 2313 4649 False False 1.81644552864877 0.243258979140325 13.5672775646283 5.94954783436458e-05 1.50629396217601e-06 0.000331442511213996 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.052853655209362 Inf 0.326658713928652 320 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 8.69489609599165e-05 2.20135467503192e-06 0.000484352330576856 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.-113delC rpoA_c.-113delC 2 upstream_gene_variant 3878619 1 3 1 2 1 3 16809 30529 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999901742434167 0.999712876815577 0.99997973646933 0.25 0.00630946320970987 0.805879550316756 0.333333333333333 0.00840375865961264 0.905700675949754 0.25 0.00630946320970987 0.805879550316756 0.908114700458088 0.0153968963607034 17.4455417793522 1 1627.5 4649 False False 0.605409800305391 0.0115361654751757 7.54087213596152 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 10.9713274274722 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.114G>A rpoA_c.114G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.75142405620251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.12235036001139 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-115C>A rpoA_c.-115C>A 2 upstream_gene_variant 3878622 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3955 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3320 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.-115C>G rpoA_c.-115C>G 2 upstream_gene_variant 3878622 1 2 0 2 1 6 16809 30526 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999803484868334 0.999572318737888 0.999927879105266 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.841886116991581 0 0 0.4592581264399 0 0 9.66990770238623 0.54198685894464 452.5 4649 False False 0.302675154183274 0.00658396461982027 2.49513982006856 0 0 0.000219434511605659 0.999803484868334 0.999572318737888 0.999927879105266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 6 11501 23701 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.9997469101953 0.999449212060655 0.99990711502044 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.841886116991581 0 0 0.4592581264399 0 0 10.9708936080245 1 1214.5 3890 False False 0 0 0 0 0 0 0 0.343462887285163 0.00747035147172492 2.83150389371471 0 0 0.000320692802708327 0.9997469101953 0.999449212060655 0.99990711502044 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.117T>G rpoA_c.117T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-119A>G rpoA_c.-119A>G 2 upstream_gene_variant 3878626 0 0 0 0 28 8 16782 30524 0.00166567519333729 0.00110710558710172 0.00240647153309903 0.999737979824446 0.999483781433772 0.999886871715824 0.777777777777777 0.608482350842618 0.898849469655087 NA NA NA 0 0 0.369416647552819 NA NA NA NA 4072 4649 False False 6.36598736741747 2.82582616679423 16.1627408751679 0 0 0.00021978751367184 0.999737979824446 0.999483781433772 0.999886871715824 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 23 6 11479 23701 0.00199965223439401 0.00126801715451488 0.0029989585229059 0.9997469101953 0.999449212060655 0.99990711502044 0.793103448275862 0.60275305077276 0.92005815112392 NA NA NA 0 0 0.4592581264399 NA NA NA NA 3420 3890 False False 0 0 0 0 0 0 0 7.91478642158143 3.13153010254931 23.7674104958734 0 0 0.000321307325583828 0.9997469101953 0.999449212060655 0.99990711502044 5 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.-120T>C rpoA_c.-120T>C 2 upstream_gene_variant 3878627 1 6 0 6 1 6 16809 30526 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999803484868334 0.999572318737888 0.999927879105266 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.54260585225547 0.0957834295462749 205.5 4649 False False 0.302675154183274 0.00658396461982027 2.49513982006856 0 0 0.000219434511605659 0.999803484868334 0.999572318737888 0.999927879105266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.-122A>C rpoA_c.-122A>C 2 upstream_gene_variant 3878629 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.-124_-53delCGAGTACCCCCCAACCCAACCCTCGGGGGGCGCCGCCCCCCGAGTACCCCCACCCTCGGGGGCGCCGCCCCC rpoA_c.-124_-53delCGAGTACCCCCCAACCCAACCCTCGGGGGGCGCCGCCCCCCGAGTACCCCCACCCTCGGGGGCGCCGCCCCC 2 upstream_gene_variant 3878559 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.-124C>T rpoA_c.-124C>T 2 upstream_gene_variant 3878631 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.-124delC rpoA_c.-124delC 2 upstream_gene_variant 3878630 NA 0 0 0 10 268 16800 30264 0.000594883997620464 0.000285305684944214 0.00109373983334496 0.991222324118957 0.990111577470224 0.992238026548426 0.0359712230215827 0.0173819624842274 0.065155795717976 NA NA NA 0 0 0.013670178327655 NA NA NA NA 3950 4649 False True 0.0672174840085287 0.0318639114354712 0.125595958188731 0 0 0.000219552052902727 0.991222324118957 0.990111577470224 0.992238026548426 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 8 141 11494 23566 0.000695531211963136 0.000300327312744212 0.00137001129783907 0.994052389589572 0.992989448577732 0.994991298196118 0.0536912751677852 0.0234621342847786 0.103050827669864 NA NA NA 0 0 0.0258229986638656 NA NA NA NA 3316 3890 False True 0 1 1 0 0 0 0 0.116328346457664 0.0492659209997207 0.235673851934688 0 0 0.000320888077582845 0.994052389589572 0.992989448577732 0.994991298196118 5 5) Not assoc w R New NotAwR yes 5 +Rifampicin rpoA c.-125C>G rpoA_c.-125C>G 2 upstream_gene_variant 3878632 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.-125C>T rpoA_c.-125C>T 2 upstream_gene_variant 3878632 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.127C>T rpoA_c.127C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 3 16808 30529 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999901742434167 0.999712876815577 0.99997973646933 0.4 0.0527449505263169 0.853367200365326 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.21089163890211 0.101157890363798 10.5697741171107 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-132_-64delCCGCCCCCCGAGTACCCCCCAACCCAACCCTCGGGGGGCGCCGCCCCCCGAGTACCCCCACCCTCGGGG rpoA_c.-132_-64delCCGCCCCCCGAGTACCCCCCAACCCAACCCTCGGGGGGCGCCGCCCCCCGAGTACCCCCACCCTCGGGG 2 upstream_gene_variant 3878570 0 0 0 0 31 11 16779 30521 0.00184414039262343 0.00125333722248032 0.00261659758042388 0.999639722258614 0.999355455254591 0.999820137367966 0.738095238095238 0.579603312882391 0.861389867911529 NA NA NA 0 0 0.284914152918154 NA NA NA NA 4025 4649 False False 5.12627255931386 2.5069951771366 11.307440968034 0 0 0.000219826806243681 0.999639722258614 0.999355455254591 0.999820137367966 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 25 7 11477 23700 0.0021735350373848 0.00140707589428017 0.00320690572089761 0.999704728561184 0.999391723222185 0.999881277590374 0.78125 0.600271736287892 0.90722846771528 NA NA NA 0 0 0.409616397225003 NA NA NA NA 3378 3890 False False 0 0 0 0 0 0 0 7.37499844409315 3.09962310117171 20.1949823315235 0 0 0.000321363308103974 0.999704728561184 0.999391723222185 0.999881277590374 7 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.-132C>G rpoA_c.-132C>G 2 upstream_gene_variant 3878639 0 0 0 0 32 12 16778 30520 0.00190362879238548 0.0013024338261299 0.00268630258659741 0.999606969736669 0.999313555980458 0.999796899563454 0.727272727272727 0.572103587544499 0.850423156234691 NA NA NA 0 0 0.264648469397051 NA NA NA NA 3968 4649 False False 4.85079667818969 2.4312379434 10.3478860830487 0 0 0.000219839906889832 0.999606969736669 0.999313555980458 0.999796899563454 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 26 8 11476 23699 0.00226047643888019 0.00147713322194328 0.00331037981655982 0.999662546927068 0.999335191784523 0.999854300817065 0.764705882352941 0.588292158092833 0.892538184224992 NA NA NA 0 0 0.369416647552819 NA NA NA NA 3332 3890 False False 0 0 0 0 0 0 0 6.71155019170442 2.94952940743403 17.1516889737674 0 0 0.00032139130668021 0.999662546927068 0.999335191784523 0.999854300817065 7 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.-133G>T rpoA_c.-133G>T 2 upstream_gene_variant 3878640 NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4073 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3421 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.-135_-134insG rpoA_c.-135_-134insG 2 upstream_gene_variant 3878641 NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3956 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.-135delG rpoA_c.-135delG 2 upstream_gene_variant 3878641 1 18 0 18 12 26 16798 30506 0.000713860797144556 0.000368914962606047 0.00124663876852724 0.999148434429451 0.998752506314373 0.99944365605196 0.31578947368421 0.175025338901126 0.486527054406021 0 0 0.185301968137852 0 0 0.132274604497754 0 0 0.413105698620438 0.000682835757998454 66 4649 True False 0.838176706018115 0.385185969209923 1.72131251239251 0 0 0.000219578190293692 0.999148434429451 0.998752506314373 0.99944365605196 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 6 8 11496 23699 0.000521648408972352 0.000191459062774625 0.00113506056981396 0.999662546927068 0.999335191784523 0.999854300817065 0.428571428571428 0.176611089982117 0.711390599961692 0 0 0.4592581264399 0 0 0.369416647552819 0 0 1.7511517825281 0.186829049695737 204 3890 False False 0 0 0 0 0 0 0 1.54612473903966 0.442058769036493 5.08197364434825 0 0 0.000320832260499258 0.999662546927068 0.999335191784523 0.999854300817065 3 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.-140G>C rpoA_c.-140G>C 2 upstream_gene_variant 3878647 NA 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3985 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3344 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.-141C>T rpoA_c.-141C>T 2 upstream_gene_variant 3878648 1 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4057 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3405 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.-145C>T rpoA_c.-145C>T 2 upstream_gene_variant 3878652 NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4012 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.-146A>C rpoA_c.-146A>C 2 upstream_gene_variant 3878653 NA 0 0 0 6 0 16804 30532 0.000356930398572278 0.000130998068917797 0.000776724091447791 1 0.999879187193184 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 4021 4649 False False Inf 2.13890645017026 Inf 0 0 0.000219499796783869 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 6 0 11496 23707 0.000521648408972352 0.000191459062774625 0.00113506056981396 1 0.999844409142079 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 3374 3890 False False 0 0 0 0 0 0 0 Inf 2.42738974088595 Inf 0 0 0.000320832260499258 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.-147A>C rpoA_c.-147A>C 2 upstream_gene_variant 3878654 NA 0 0 0 6 0 16804 30532 0.000356930398572278 0.000130998068917797 0.000776724091447791 1 0.999879187193184 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 4058 4649 False False Inf 2.13890645017026 Inf 0 0 0.000219499796783869 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 6 0 11496 23707 0.000521648408972352 0.000191459062774625 0.00113506056981396 1 0.999844409142079 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 3406 3890 False False 0 0 0 0 0 0 0 Inf 2.42738974088595 Inf 0 0 0.000320832260499258 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.-147A>G rpoA_c.-147A>G 2 upstream_gene_variant 3878654 1 6 0 6 0 8 16810 30524 0 0 0.000219421459229958 0.999737979824446 0.999483781433772 0.999886871715824 0 0 0.369416647552819 0 0 0.4592581264399 0 0 0.369416647552819 0 0 1.54241302632406 0.0957730714925599 184.5 4649 False False 0 0 1.06393155676265 0 0 0.000219421459229958 0.999737979824446 0.999483781433772 0.999886871715824 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 7 11502 23700 0 0 0.000320664925697395 0.999704728561184 0.999391723222185 0.999881277590374 0 0 0.409616397225003 0 0 0.521823750104981 0 0 0.409616397225003 0 0 2.24893704635384 0.180414610937576 164.5 3890 False False 0 0 0 0 0 0 0 0 0 1.42986888806462 0 0 0.000320664925697395 0.999704728561184 0.999391723222185 0.999881277590374 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.150C>T rpoA_c.150C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-153A>G rpoA_c.-153A>G 2 upstream_gene_variant 3878660 1 2 0 2 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 9.67028206568003 0.541992006917746 476.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 10.9713274274722 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.-155G>A rpoA_c.-155G>A 2 upstream_gene_variant 3878662 1 2 0 2 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 9.67028206568003 0.541992006917746 476.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 10.9713274274722 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.-158A>G rpoA_c.-158A>G 2 upstream_gene_variant 3878665 1 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4053 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3401 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance No change no 1 +Rifampicin rpoA c.159C>T rpoA_c.159C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.15G>A rpoA_c.15G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 27 16808 30505 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999115681907506 0.998713622442022 0.999417150456935 0.0689655172413793 0.00846396225300182 0.227661889944486 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.13443774569429 0.0154753108479799 0.535111557826152 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 26 11500 23681 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.99890327751297 0.998393457445096 0.999283463292248 0.0714285714285714 0.00877049670352713 0.23503477317459 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.158401337792642 0.018232369470155 0.632881988905538 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-161C>T rpoA_c.-161C>T 2 upstream_gene_variant 3878668 NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4035 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3387 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.165C>T rpoA_c.165C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-170C>T rpoA_c.-170C>T 2 upstream_gene_variant 3878677 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance No change no 1 +Rifampicin rpoA c.171T>C rpoA_c.171T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-172G>A rpoA_c.-172G>A 2 upstream_gene_variant 3878679 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4059 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3407 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.-173C>T rpoA_c.-173C>T 2 upstream_gene_variant 3878680 1 5 0 5 2 5 16808 30527 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999836237390279 0.999617874429585 0.999946824656822 0.285714285714285 0.0366925661760855 0.709579136262657 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.98225896975909 0.168456568596501 274 4649 False False 0.726487386958591 0.069161301215026 4.43811993507661 0 0 0.000219447565534303 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 2 4 11500 23703 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999831273463534 0.999568049920357 0.99995402584539 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12289352368013 0.310805712195535 291 3890 False False 0 0 0 0 0 0 0 1.0305652173913 0.0931903474189042 7.19201282268065 0 0 0.000320720684566658 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.174T>C rpoA_c.174T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-176G>A rpoA_c.-176G>A 2 upstream_gene_variant 3878683 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4026 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3379 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.177A>G rpoA_c.177A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.178C>T rpoA_c.178C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-17A>G rpoA_c.-17A>G 2 upstream_gene_variant 3878524 NA 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3995 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3352 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.-18_-17insT rpoA_c.-18_-17insT 2 upstream_gene_variant 3878524 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3974 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3335 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.-180A>C rpoA_c.-180A>C 2 upstream_gene_variant 3878687 1 24 2 22 7 27 16803 30505 0.000416418798334324 0.000167437820935922 0.000857792460925722 0.999115681907506 0.998713622442022 0.999417150456935 0.205882352941176 0.087021305458127 0.378977748539683 0.0833333333333333 0.0102563412812501 0.269972801557603 0.0689655172413793 0.00846396225300182 0.227661889944486 0.165040874735572 0.0188210344875355 0.671527463249032 0.00447740016639746 87 4649 False False 0.47067212424589 0.173035558910641 1.10819526424395 0.000119012198750371 1.44132543749393e-05 0.000429846157359588 0.999115681907506 0.998713622442022 0.999417150456935 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 19 1 18 4 22 11498 23685 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 0.999072004049436 0.998595338091004 0.999418341378366 0.153846153846153 0.0435634765389238 0.348678785535361 0.0526315789473684 0.00133162880417942 0.260280654195214 0.0434782608695652 0.0011001686304415 0.21948660745348 0.114440192497245 0.00275052103608063 0.724995970483645 0.0117346285417173 80 3890 False False 0 0 0 0 0 0 0 0.374531539081895 0.093785115174616 1.1031581004358 8.69640838333768e-05 2.20173755219544e-06 0.00048443655634461 0.999072004049436 0.998595338091004 0.999418341378366 5 3) Uncertain significance No change no 1 +Rifampicin rpoA c.186A>G rpoA_c.186A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 3 16809 30529 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999901742434167 0.999712876815577 0.99997973646933 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.605409800305391 0.0115361654751757 7.54087213596152 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-186C>T rpoA_c.-186C>T 2 upstream_gene_variant 3878693 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.-188C>T rpoA_c.-188C>T 2 upstream_gene_variant 3878695 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.18C>T rpoA_c.18C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.192C>A rpoA_c.192C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.195G>C rpoA_c.195G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.198G>T rpoA_c.198G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-200C>T rpoA_c.-200C>T 2 upstream_gene_variant 3878707 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.201C>T rpoA_c.201C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-202A>C rpoA_c.-202A>C 2 upstream_gene_variant 3878709 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3996 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3353 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.-206G>A rpoA_c.-206G>A 2 upstream_gene_variant 3878713 1 4 0 4 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.75142405620251 0.304356294847217 327.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12235036001139 0.310791984491028 261 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.207C>G rpoA_c.207C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.210A>G rpoA_c.210A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-214G>A rpoA_c.-214G>A 2 upstream_gene_variant 3878721 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.-214G>C rpoA_c.-214G>C 2 upstream_gene_variant 3878721 1 1 0 1 1 4 16809 30528 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999868989912223 0.999664596427238 0.999964303043777 0.2 0.00505076337946806 0.716417936118089 0 0 0.975 0 0 0.602364635616474 0 0 70.755742229929 1 1627.5 4649 False False 0.454042477244333 0.00922341562850508 4.58878013974823 0 0 0.000219434511605659 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 4 11501 23703 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999831273463534 0.999568049920357 0.99995402584539 0.2 0.00505076337946806 0.716417936118089 0 0 0.975 0 0 0.602364635616474 0 0 80.2809146182867 1 1214.5 3890 False False 0 0 0 0 0 0 0 0.515237805408225 0.0104655802548345 5.20753049950472 0 0 0.000320692802708327 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.-215C>G rpoA_c.-215C>G 2 upstream_gene_variant 3878722 1 0 0 0 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4075 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3423 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 4 3) Uncertain significance No change no 1 +Rifampicin rpoA c.-215C>T rpoA_c.-215C>T 2 upstream_gene_variant 3878722 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance No change no 1 +Rifampicin rpoA c.216T>C rpoA_c.216T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.21C>T rpoA_c.21C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.231C>A rpoA_c.231C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.232C>T rpoA_c.232C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.237T>C rpoA_c.237T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-238C>G rpoA_c.-238C>G 2 upstream_gene_variant 3878745 1 0 0 0 21 3 16789 30529 0.00124925639500297 0.000773470498752546 0.00190899053306069 0.999901742434167 0.999712876815577 0.99997973646933 0.875 0.676388641811167 0.973440685013751 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4022 4649 False False 12.7287509678956 3.79963297559447 66.7836139022247 0 0 0.000219695885606983 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 20 3 11482 23704 0.00173882802990784 0.00106243473911297 0.00268420764151461 0.99987345509765 0.999630227076139 0.999973902638554 0.869565217391304 0.664110862462879 0.972248492577206 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3375 3890 False False 0 0 0 0 0 0 0 13.7629913487777 4.08024201918457 72.3328008782773 0 0 0.00032122338836531 0.99987345509765 0.999630227076139 0.999973902638554 1 3) Uncertain significance No change no 1 +Rifampicin rpoA c.-239A>G rpoA_c.-239A>G 2 upstream_gene_variant 3878746 1 0 0 0 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4040 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3392 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 4 3) Uncertain significance No change no 1 +Rifampicin rpoA c.240C>T rpoA_c.240C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 9 16807 30523 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999705227302502 0.999440503684993 0.999865202576615 0.25 0.0548606445279927 0.571858461878189 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.605362844846393 0.105379149073638 2.42624598182925 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 7 11501 23700 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999704728561184 0.999391723222185 0.999881277590374 0.125 0.0031597235312519 0.526509670875206 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.294384339250003 0.00653526389697788 2.29204336611244 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-242G>A rpoA_c.-242G>A 2 upstream_gene_variant 3878749 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.246C>T rpoA_c.246C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 7 0 16803 30532 0.000416418798334324 0.000167437820935922 0.000857792460925722 1 0.999879187193184 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 2.61832748907777 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-249G>A rpoA_c.-249G>A 2 upstream_gene_variant 3878756 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4036 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3388 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.249G>C rpoA_c.249G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-249G>C rpoA_c.-249G>C 2 upstream_gene_variant 3878756 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.24C>T rpoA_c.24C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-253G>A rpoA_c.-253G>A 2 upstream_gene_variant 3878760 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.-253G>C rpoA_c.-253G>C 2 upstream_gene_variant 3878760 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3989 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3347 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.-254G>A rpoA_c.-254G>A 2 upstream_gene_variant 3878761 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.-256G>T rpoA_c.-256G>T 2 upstream_gene_variant 3878763 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3934 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.-268A>G rpoA_c.-268A>G 2 upstream_gene_variant 3878775 NA 0 0 0 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 4013 4649 False False Inf 1.1990579265185 Inf 0 0 0.000219473678051534 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3367 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.-272C>T rpoA_c.-272C>T 2 upstream_gene_variant 3878779 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.273G>A rpoA_c.273G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-276C>T rpoA_c.-276C>T 2 upstream_gene_variant 3878783 1 12 1 11 1 12 16809 30520 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999606969736669 0.999313555980458 0.999796899563454 0.0769230769230769 0.00194562849734675 0.360297435267877 0.0833333333333333 0.00210759323186022 0.384796165150944 0.0769230769230769 0.00194562849734675 0.360297435267877 0.165063088496963 0.00383865388159642 1.13588906045674 0.0672467094200718 182 4649 False False 0.151307831122216 0.00354340542289597 1.02280787579455 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999606969736669 0.999313555980458 0.999796899563454 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 12 1 11 1 12 11501 23695 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999493820390602 0.999115973206486 0.999738423129043 0.0769230769230769 0.00194562849734675 0.360297435267877 0.0833333333333333 0.00210759323186022 0.384796165150944 0.0769230769230769 0.00194562849734675 0.360297435267877 0.187295966358656 0.00435493881107868 1.28896694842028 0.119188468593414 159 3890 False False 0 0 0 0 0 0 0 0.171687969162101 0.00401993268933778 1.16069064496843 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999493820390602 0.999115973206486 0.999738423129043 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.-277C>T rpoA_c.-277C>T 2 upstream_gene_variant 3878784 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.279C>T rpoA_c.279C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-27C>T rpoA_c.-27C>T 2 upstream_gene_variant 3878534 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.-281G>C rpoA_c.-281G>C 2 upstream_gene_variant 3878788 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.-284C>T rpoA_c.-284C>T 2 upstream_gene_variant 3878791 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.-287G>C rpoA_c.-287G>C 2 upstream_gene_variant 3878794 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.288C>T rpoA_c.288C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-288C>T rpoA_c.-288C>T 2 upstream_gene_variant 3878795 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.291A>G rpoA_c.291A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-293G>C rpoA_c.-293G>C 2 upstream_gene_variant 3878800 NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4002 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.294C>T rpoA_c.294C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-296G>C rpoA_c.-296G>C 2 upstream_gene_variant 3878803 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.-297G>T rpoA_c.-297G>T 2 upstream_gene_variant 3878804 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4014 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.-298C>T rpoA_c.-298C>T 2 upstream_gene_variant 3878805 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.-29G>T rpoA_c.-29G>T 2 upstream_gene_variant 3878536 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.-301G>A rpoA_c.-301G>A 2 upstream_gene_variant 3878808 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.303T>C rpoA_c.303T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.303T>G rpoA_c.303T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-305G>A rpoA_c.-305G>A 2 upstream_gene_variant 3878812 1 0 0 0 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 3942 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 0 0 0.000219447565534303 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 3310 3890 False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 0 0 0.000320720684566658 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.-309T>G rpoA_c.-309T>G 2 upstream_gene_variant 3878816 1 7 0 7 0 7 16810 30525 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 1.26007067420399 0.0561478031672613 154 4649 False False 0 0 1.26007067420399 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 7 11502 23700 0 0 0.000320664925697395 0.999704728561184 0.999391723222185 0.999881277590374 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 1.42986888806462 0.104255162462523 134.5 3890 False False 0 0 0 0 0 0 0 0 0 1.42986888806462 0 0 0.000320664925697395 0.999704728561184 0.999391723222185 0.999881277590374 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.30C>T rpoA_c.30C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-310T>A rpoA_c.-310T>A 2 upstream_gene_variant 3878817 NA 0 0 0 20 96 16790 30436 0.00118976799524092 0.000726887900057249 0.00183690503094944 0.996855757893357 0.996161678018412 0.997452434051451 0.172413793103448 0.108612668947436 0.253642420803777 NA NA NA 0 0 0.0376969216235875 NA NA NA NA NA NA False True 0.377655350406988 0.220803911080214 0.616328103560555 0 0 0.000219682802119661 0.996855757893357 0.996161678018412 0.997452434051451 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 13 71 11489 23636 0.00113023821944009 0.000601937155487611 0.00193196626494298 0.997005103977728 0.996223825356722 0.997660242951721 0.154761904761904 0.0850593465028193 0.250097680871841 NA NA NA 0 0 0.0506294079544037 NA NA NA NA NA NA False True 0 1 1 0 0 1 0 0.376683637380029 0.191201817282541 0.686493403060649 0 0 0.000321027705298525 0.997005103977728 0.996223825356722 0.997660242951721 19 Not assoc w R 5) Not assoc w R No change yes 1 +Rifampicin rpoA c.-310T>C rpoA_c.-310T>C 2 upstream_gene_variant 3878817 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3997 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3354 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.312G>A rpoA_c.312G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.315T>C rpoA_c.315T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-316G>A rpoA_c.-316G>A 2 upstream_gene_variant 3878823 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.-317G>A rpoA_c.-317G>A 2 upstream_gene_variant 3878824 NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4047 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.318C>T rpoA_c.318C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-321A>G rpoA_c.-321A>G 2 upstream_gene_variant 3878828 NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3957 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3321 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.-322A>C rpoA_c.-322A>C 2 upstream_gene_variant 3878829 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.324C>T rpoA_c.324C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-324T>G rpoA_c.-324T>G 2 upstream_gene_variant 3878831 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.-329G>C rpoA_c.-329G>C 2 upstream_gene_variant 3878836 1 0 0 0 0 14 16810 30518 0 0 0.000219421459229958 0.999541464692781 0.999230775228684 0.999749292529582 0 0 0.231635761650116 NA NA NA 0 0 0.231635761650116 NA NA NA NA 4067 4649 False False 0 0 0.547412779991011 0 0 0.000219421459229958 0.999541464692781 0.999230775228684 0.999749292529582 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 13 11502 23694 0 0 0.000320664925697395 0.999451638756485 0.999062468123692 0.999707989454911 0 0 0.24705263800047 NA NA NA 0 0 0.24705263800047 NA NA NA NA 3414 3890 False False 0 0 0 0 0 0 0 0 0 0.676068752178923 0 0 0.000320664925697395 0.999451638756485 0.999062468123692 0.999707989454911 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.333G>A rpoA_c.333G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-338G>A rpoA_c.-338G>A 2 upstream_gene_variant 3878845 1 3 0 3 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 4.39540875925228 0.556930310247326 910.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 4.98803779447094 0.555669835711629 381 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 1 3) Uncertain significance No change no 1 +Rifampicin rpoA c.339G>C rpoA_c.339G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-339T>C rpoA_c.-339T>C 2 upstream_gene_variant 3878846 NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4044 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3395 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.-339T>G rpoA_c.-339T>G 2 upstream_gene_variant 3878846 1 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4018 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3371 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.-341C>T rpoA_c.-341C>T 2 upstream_gene_variant 3878848 1 1 0 1 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 0 0 0.975 0 0 0.521823750104981 0 0 70.7492227801408 1 1627.5 4649 False False 0 0 1.9820231071276 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 0 0 0.975 0 0 0.521823750104981 0 0 80.2705613703955 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 2.24912710990902 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 4 3) Uncertain significance No change no 1 +Rifampicin rpoA c.342C>T rpoA_c.342C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.345C>T rpoA_c.345C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.348C>G rpoA_c.348C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-34C>T rpoA_c.-34C>T 2 upstream_gene_variant 3878541 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4045 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.-350C>T rpoA_c.-350C>T 2 upstream_gene_variant 3878857 1 4 0 4 1 6 16809 30526 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999803484868334 0.999572318737888 0.999927879105266 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.602364635616474 0 0 0.4592581264399 0 0 2.75140749635656 0.304356159527193 310 4649 False False 0.302675154183274 0.00658396461982027 2.49513982006856 0 0 0.000219434511605659 0.999803484868334 0.999572318737888 0.999927879105266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 1 6 11501 23701 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.9997469101953 0.999449212060655 0.99990711502044 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.602364635616474 0 0 0.4592581264399 0 0 3.12235841010577 0.310792185446741 282 3890 False False 0 0 0 0 0 0 0 0.343462887285163 0.00747035147172492 2.83150389371471 0 0 0.000320692802708327 0.9997469101953 0.999449212060655 0.99990711502044 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.351C>T rpoA_c.351C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-354A>T rpoA_c.-354A>T 2 upstream_gene_variant 3878861 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.-356G>T rpoA_c.-356G>T 2 upstream_gene_variant 3878863 1 19 0 19 0 19 16810 30513 0 0 0.000219421459229958 0.99937770208306 0.999028374542228 0.999625295739155 0 0 0.176466911806965 0 0 0.176466911806965 0 0 0.176466911806965 0 0 0.38900423869522 0.000378242337488445 62 4649 True False 0 0 0.38900423869522 0 0 0.000219421459229958 0.99937770208306 0.999028374542228 0.999625295739155 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 19 0 19 0 19 11502 23688 0 0 0.000320664925697395 0.999198548951786 0.998748716594888 0.999517407326546 0 0 0.176466911806965 0 0 0.176466911806965 0 0 0.176466911806965 0 0 0.441417616308252 0.00084255514542942 45 3890 False False 0 0 0 0 0 0 0 0 0 0.441417616308252 0 0 0.000320664925697395 0.999198548951786 0.998748716594888 0.999517407326546 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.-367C>T rpoA_c.-367C>T 2 upstream_gene_variant 3878874 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.-368C>T rpoA_c.-368C>T 2 upstream_gene_variant 3878875 1 13 0 13 54 46 16756 30486 0.0032123735871505 0.00241412734534404 0.00418939791764501 0.998493383990567 0.997990890889788 0.998896763100815 0.54 0.437411579866471 0.640156647020587 0 0 0.24705263800047 0 0 0.0770618270519006 0 0 0.597077314390605 0.00617815987713984 95 4649 False False 2.13582675122214 1.41386596452039 3.23841127376569 0 0 0.000220128516676725 0.998493383990567 0.997990890889788 0.998896763100815 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 41 24 11461 23683 0.00356459746131107 0.00255919435806085 0.00483270406615093 0.998987640781203 0.998494061778372 0.999351258026211 0.63076923076923 0.501999389700979 0.747206484837992 0 0 0.409616397225003 0 0 0.142473597722525 0 0 1.43398559284919 0.104326334533819 143 3890 False False 0 0 0 0 0 0 0 3.53009844981531 2.08178803825218 6.11075069808472 0 0 0.000321811871535852 0.998987640781203 0.998494061778372 0.999351258026211 23 3) Uncertain significance No change no 1 +Rifampicin rpoA c.-369A>G rpoA_c.-369A>G 2 upstream_gene_variant 3878876 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.36C>T rpoA_c.36C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-371T>C rpoA_c.-371T>C 2 upstream_gene_variant 3878878 1 8 0 8 1 14 16809 30518 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999541464692781 0.999230775228684 0.999749292529582 0.0666666666666666 0.0016864302413527 0.319484566578303 0 0 0.369416647552819 0 0 0.231635761650116 0 0 1.06378572772383 0.0571721907691662 181 4649 False False 0.129683927827779 0.00307091319956987 0.852531396269756 0 0 0.000219434511605659 0.999541464692781 0.999230775228684 0.999749292529582 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 0 14 11502 23693 0 0 0.000320664925697395 0.999409457122369 0.999009367705732 0.999677108302285 0 0 0.231635761650116 0 0 0.369416647552819 0 0 0.231635761650116 0 0 1.20701206151267 0.0599032409488318 113 3890 False False 0 0 0 0 0 0 0 0 0 0.621144612257265 0 0 0.000320664925697395 0.999409457122369 0.999009367705732 0.999677108302285 4 3) Uncertain significance No change no 1 +Rifampicin rpoA c.-379G>A rpoA_c.-379G>A 2 upstream_gene_variant 3878886 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.-37C>T rpoA_c.-37C>T 2 upstream_gene_variant 3878544 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.382C>T rpoA_c.382C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 3 16809 30529 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999901742434167 0.999712876815577 0.99997973646933 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.605409800305391 0.0115361654751757 7.54087213596152 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-385_-383dupGTC rpoA_c.-385_-383dupGTC 2 upstream_gene_variant 3878889 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4032 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3385 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.-388C>G rpoA_c.-388C>G 2 upstream_gene_variant 3878895 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4041 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3393 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.-388C>T rpoA_c.-388C>T 2 upstream_gene_variant 3878895 1 3 0 3 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 4.3952647534881 0.556931257223419 920.5 4649 False False 0 0 1.9820231071276 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 10.9713274274722 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.-390T>C rpoA_c.-390T>C 2 upstream_gene_variant 3878897 1 2 0 2 0 6 16810 30526 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 0 0 0.4592581264399 0 0 0.841886116991581 0 0 0.4592581264399 0 0 9.66933336511864 0.541978962766188 450.5 4649 False False 0 0 1.54251408011679 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 0 0 0.841886116991581 0 0 0.521823750104981 0 0 10.970403447915 1 504 3890 False False 0 0 0 0 0 0 0 0 0 2.24912710990902 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.396C>T rpoA_c.396C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-398C>G rpoA_c.-398C>G 2 upstream_gene_variant 3878905 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.-398C>T rpoA_c.-398C>T 2 upstream_gene_variant 3878905 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance No change no 1 +Rifampicin rpoA c.399G>A rpoA_c.399G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.39C>T rpoA_c.39C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-402A>T rpoA_c.-402A>T 2 upstream_gene_variant 3878909 NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4027 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3380 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.-407T>C rpoA_c.-407T>C 2 upstream_gene_variant 3878914 1 0 0 0 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4082 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3429 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 4 3) Uncertain significance No change no 1 +Rifampicin rpoA c.-409C>A rpoA_c.-409C>A 2 upstream_gene_variant 3878916 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4076 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3424 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.-410G>A rpoA_c.-410G>A 2 upstream_gene_variant 3878917 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.-412G>A rpoA_c.-412G>A 2 upstream_gene_variant 3878919 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.-416C>T rpoA_c.-416C>T 2 upstream_gene_variant 3878923 1 22 0 22 4 22 16806 30510 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999279444517227 0.998909272375137 0.999548378362908 0.153846153846153 0.0435634765389238 0.348678785535361 0 0 0.154372512815574 0 0 0.154372512815574 0 0 0.331472693563184 7.57819248397783e-05 47 4649 True False 0.330076920580312 0.0826999724521732 0.972089303633469 0 0 0.000219473678051534 0.999279444517227 0.998909272375137 0.999548378362908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 19 0 19 4 19 11498 23688 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 0.999198548951786 0.998748716594888 0.999517407326546 0.17391304347826 0.0495076453057934 0.387811889954797 0 0 0.176466911806965 0 0 0.176466911806965 0 0 0.441571027072243 0.000842901658697533 46 3890 False False 0 0 0 0 0 0 0 0.433723027345716 0.107278289789593 1.30550898759153 0 0 0.000320776462830572 0.999198548951786 0.998748716594888 0.999517407326546 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.417C>T rpoA_c.417C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.426T>G rpoA_c.426T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.429C>T rpoA_c.429C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-439C>A rpoA_c.-439C>A 2 upstream_gene_variant 3878946 NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3969 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.-43C>A rpoA_c.-43C>A 2 upstream_gene_variant 3878550 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.-43delC rpoA_c.-43delC 2 upstream_gene_variant 3878549 NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4003 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3358 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.-440G>C rpoA_c.-440G>C 2 upstream_gene_variant 3878947 1 0 0 0 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4029 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3382 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 4 3) Uncertain significance No change no 1 +Rifampicin rpoA c.441C>T rpoA_c.441C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 5 0 16805 30532 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 1 0.999879187193184 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.66460481015123 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 5 0 11497 23707 0.00043470700747696 0.000141162766530747 0.00101416710312943 1 0.999844409142079 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.88913119689894 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-448C>A rpoA_c.-448C>A 2 upstream_gene_variant 3878955 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.-449G>A rpoA_c.-449G>A 2 upstream_gene_variant 3878956 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.450G>C rpoA_c.450G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-454C>T rpoA_c.-454C>T 2 upstream_gene_variant 3878961 1 1 0 1 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 0 0 0.975 0 0 0.521823750104981 0 0 70.7492227801408 1 1627.5 4649 False False 0 0 1.9820231071276 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3322 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 6 3) Uncertain significance No change no 1 +Rifampicin rpoA c.-455G>A rpoA_c.-455G>A 2 upstream_gene_variant 3878962 1 0 0 0 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3990 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3348 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 4 3) Uncertain significance No change no 1 +Rifampicin rpoA c.-458C>T rpoA_c.-458C>T 2 upstream_gene_variant 3878965 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.-459C>T rpoA_c.-459C>T 2 upstream_gene_variant 3878966 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.459G>A rpoA_c.459G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.75142405620251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.12235036001139 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-461T>C rpoA_c.-461T>C 2 upstream_gene_variant 3878968 1 0 0 0 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3965 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3329 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 4 3) Uncertain significance No change no 1 +Rifampicin rpoA c.-463C>T rpoA_c.-463C>T 2 upstream_gene_variant 3878970 NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3943 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3311 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.-467C>T rpoA_c.-467C>T 2 upstream_gene_variant 3878974 1 2 0 2 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 9.66996583219897 0.541987658825864 457.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3415 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 1 3) Uncertain significance No change no 1 +Rifampicin rpoA c.468T>C rpoA_c.468T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-469A>G rpoA_c.-469A>G 2 upstream_gene_variant 3878976 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.-473C>T rpoA_c.-473C>T 2 upstream_gene_variant 3878980 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3958 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3323 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.480G>A rpoA_c.480G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-485C>T rpoA_c.-485C>T 2 upstream_gene_variant 3878992 1 2 0 2 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.67117271135833 0.542004252564565 721 4649 False False 0.908144446427509 0.0153974005043644 17.4461131425891 0 0 0.000219434511605659 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.48C>T rpoA_c.48C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-48G>A rpoA_c.-48G>A 2 upstream_gene_variant 3878555 1 1 0 1 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 70.7515377372301 1 1627.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.-491C>G rpoA_c.-491C>G 2 upstream_gene_variant 3878998 1 0 0 0 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4015 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3368 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 4 3) Uncertain significance No change no 1 +Rifampicin rpoA c.-491C>T rpoA_c.-491C>T 2 upstream_gene_variant 3878998 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.492C>T rpoA_c.492C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-493C>G rpoA_c.-493C>G 2 upstream_gene_variant 3879000 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3998 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.-497G>C rpoA_c.-497G>C 2 upstream_gene_variant 3879004 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.-4C>T rpoA_c.-4C>T 2 upstream_gene_variant 3878511 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.-503G>A rpoA_c.-503G>A 2 upstream_gene_variant 3879010 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.-505C>T rpoA_c.-505C>T 2 upstream_gene_variant 3879012 NA 0 0 0 5 0 16805 30532 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 1 0.999879187193184 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 3999 4649 False False Inf 1.66460481015123 Inf 0 0 0.000219486736640675 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3355 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.507A>G rpoA_c.507A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 4 16809 30528 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999868989912223 0.999664596427238 0.999964303043777 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.454042477244333 0.00922341562850508 4.58878013974823 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 4 11501 23703 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999831273463534 0.999568049920357 0.99995402584539 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.515237805408225 0.0104655802548345 5.20753049950472 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-507A>G rpoA_c.-507A>G 2 upstream_gene_variant 3879014 NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3944 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.-50G>C rpoA_c.-50G>C 2 upstream_gene_variant 3878557 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.510G>T rpoA_c.510G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-515G>A rpoA_c.-515G>A 2 upstream_gene_variant 3879022 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.519A>G rpoA_c.519A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.51C>T rpoA_c.51C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.522G>A rpoA_c.522G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-524C>T rpoA_c.-524C>T 2 upstream_gene_variant 3879031 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.-528A>G rpoA_c.-528A>G 2 upstream_gene_variant 3879035 NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4060 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3408 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.-532C>G rpoA_c.-532C>G 2 upstream_gene_variant 3879039 1 3 0 3 1 3 16809 30529 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999901742434167 0.999712876815577 0.99997973646933 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.39581433818102 0.556927644280045 795 4649 False False 0.605409800305391 0.0115361654751757 7.54087213596152 0 0 0.000219434511605659 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 3 11501 23704 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.99987345509765 0.999630227076139 0.999973902638554 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98868218084989 0.555670981350655 466 3890 False False 0 0 0 0 0 0 0 0.687012723531287 0.0130900577164196 8.55773267307823 0 0 0.000320692802708327 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.-532C>T rpoA_c.-532C>T 2 upstream_gene_variant 3879039 NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4023 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3376 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.-533G>A rpoA_c.-533G>A 2 upstream_gene_variant 3879040 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.534G>T rpoA_c.534G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.537C>T rpoA_c.537C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 7 16810 30525 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.26007067420399 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 6 11502 23701 0 0 0.000320664925697395 0.9997469101953 0.999449212060655 0.99990711502044 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.75038628279554 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.540C>T rpoA_c.540C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.908144446427509 0.0153974005043644 17.4461131425891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.546G>A rpoA_c.546G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.546G>T rpoA_c.546G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.549C>T rpoA_c.549C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-54C>G rpoA_c.-54C>G 2 upstream_gene_variant 3878561 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.561C>A rpoA_c.561C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.341150751115529 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.564C>T rpoA_c.564C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.570C>T rpoA_c.570C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.57C>T rpoA_c.57C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.585C>T rpoA_c.585C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 1 16807 30531 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999967247478055 0.999817528289014 0.999999170778282 0.75 0.194120449683243 0.99369053679029 NA NA NA NA NA NA NA NA NA NA NA NA False False 5.44969358005592 0.437509494081317 285.652299683162 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.588G>C rpoA_c.588G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-6_-5insGAA rpoA_c.-6_-5insGAA 2 upstream_gene_variant 3878512 1 0 0 0 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4069 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3417 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA c.600T>C rpoA_c.600T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.603A>G rpoA_c.603A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.615C>T rpoA_c.615C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.621G>A rpoA_c.621G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.75142405620251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.12235036001139 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.622C>T rpoA_c.622C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.75142405620251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.12235036001139 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-63_-62insG rpoA_c.-63_-62insG 2 upstream_gene_variant 3878569 1 1 0 1 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 70.7603724184383 1 1627.5 4649 False False 0.908144446427509 0.0153974005043644 17.4461131425891 0 0 0.000219434511605659 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 2 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.630G>T rpoA_c.630G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.1990579265185 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.633T>C rpoA_c.633T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.636C>G rpoA_c.636C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.636C>T rpoA_c.636C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.639G>A rpoA_c.639G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-63delG rpoA_c.-63delG 2 upstream_gene_variant 3878569 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.-63G>A rpoA_c.-63G>A 2 upstream_gene_variant 3878570 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4004 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3359 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.642G>T rpoA_c.642G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.648C>A rpoA_c.648C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-64G>T rpoA_c.-64G>T 2 upstream_gene_variant 3878571 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4068 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3416 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.652T>C rpoA_c.652T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-65G>C rpoA_c.-65G>C 2 upstream_gene_variant 3878572 NA 0 0 0 7 0 16803 30532 0.000416418798334324 0.000167437820935922 0.000857792460925722 1 0.999879187193184 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 4037 4649 False False Inf 2.61832748907777 Inf 0 0 0.000219512858481393 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 6 0 11496 23707 0.000521648408972352 0.000191459062774625 0.00113506056981396 1 0.999844409142079 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 3389 3890 False False 0 0 0 0 0 0 0 Inf 2.42738974088595 Inf 0 0 0.000320832260499258 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.660C>T rpoA_c.660C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.667C>A rpoA_c.667C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.669G>A rpoA_c.669G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.669G>C rpoA_c.669G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.750576632084797 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.672A>G rpoA_c.672A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.341150751115529 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.681C>G rpoA_c.681C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.681C>T rpoA_c.681C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.684G>A rpoA_c.684G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.687C>T rpoA_c.687C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-68C>A rpoA_c.-68C>A 2 upstream_gene_variant 3878575 1 0 0 0 1 13 16809 30519 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999574217214725 0.999272008529012 0.999773269742809 0.0714285714285714 0.00180678065912538 0.338684489931821 NA NA NA 0 0 0.24705263800047 NA NA NA NA 3975 4649 False False 0.13966419088675 0.00329026829360959 0.930004555944598 0 0 0.000219434511605659 0.999574217214725 0.999272008529012 0.999773269742809 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 5 11501 23702 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999789091829417 0.999507879904061 0.999931515258336 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA 0 0 0.521823750104981 NA NA NA NA 3336 3890 False False 0 0 0 0 0 0 0 0.412172854534388 0.00871781959321125 3.68423590106777 0 0 0.000320692802708327 0.999789091829417 0.999507879904061 0.999931515258336 3 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.-68C>T rpoA_c.-68C>T 2 upstream_gene_variant 3878575 NA 0 0 0 57 297 16753 30235 0.00339083878643664 0.0025691692652669 0.00439102203662388 0.990272500982575 0.989107301659985 0.991342933912776 0.161016949152542 0.124291935056612 0.203526354240291 NA NA NA 0 0 0.0123436538684561 NA NA NA NA 3945 4649 False True 0.346366427963753 0.255994045337477 0.461512758113695 0 0 0.000220167931279891 0.990272500982575 0.989107301659985 0.991342933912776 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 27 83 11475 23624 0.00234741784037558 0.0015475155067352 0.00341354562468017 0.99649892436833 0.995661711782549 0.997210477144955 0.245454545454545 0.168406598204789 0.336674880773693 NA NA NA 0 0 0.0434711521664418 NA NA NA NA 3312 3890 False True 0 1 1 0 0 0 0 0.66970942593905 0.41667411104814 1.04562692590622 0 0 0.000321419310135588 0.99649892436833 0.995661711782549 0.997210477144955 20 5) Not assoc w R New NotAwR yes 5 +Rifampicin rpoA c.690A>G rpoA_c.690A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.693C>T rpoA_c.693C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.908144446427509 0.0153974005043644 17.4461131425891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.699G>A rpoA_c.699G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.711G>A rpoA_c.711G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.714G>C rpoA_c.714G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.717C>T rpoA_c.717C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-71C>A rpoA_c.-71C>A 2 upstream_gene_variant 3878578 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.723C>G rpoA_c.723C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.726T>C rpoA_c.726T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.729C>T rpoA_c.729C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-72C>A rpoA_c.-72C>A 2 upstream_gene_variant 3878579 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4042 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.732T>C rpoA_c.732T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.738A>G rpoA_c.738A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-73A>G rpoA_c.-73A>G 2 upstream_gene_variant 3878580 NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4019 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3372 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.-74_-73insCAACCCA rpoA_c.-74_-73insCAACCCA 2 upstream_gene_variant 3878580 1 0 0 0 1 6 16809 30526 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999803484868334 0.999572318737888 0.999927879105266 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA 0 0 0.4592581264399 NA NA NA NA 4054 4649 False False 0.302675154183274 0.00658396461982027 2.49513982006856 0 0 0.000219434511605659 0.999803484868334 0.999572318737888 0.999927879105266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 11502 23701 0 0 0.000320664925697395 0.9997469101953 0.999449212060655 0.99990711502044 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 3402 3890 False False 0 0 0 0 0 0 0 0 0 1.75038628279554 0 0 0.000320664925697395 0.9997469101953 0.999449212060655 0.99990711502044 2 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.744C>G rpoA_c.744C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.747G>A rpoA_c.747G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.756C>T rpoA_c.756C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 16810 30526 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.54251408011679 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 6 11502 23701 0 0 0.000320664925697395 0.9997469101953 0.999449212060655 0.99990711502044 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.75038628279554 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.759C>T rpoA_c.759C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.1990579265185 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 4 0 11498 23707 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 1 0.999844409142079 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.3608069907404 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.760C>T rpoA_c.760C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.765T>C rpoA_c.765T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.768G>A rpoA_c.768G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.75142405620251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.12235036001139 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.76C>T rpoA_c.76C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 6 10 16804 30522 0.000356930398572278 0.000130998068917797 0.000776724091447791 0.999672474780558 0.999397752220648 0.999842928110511 0.375 0.151983675081122 0.645653905697921 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.08981194953582 0.325465735736083 3.31043640988092 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 6 9 11496 23698 0.000521648408972352 0.000191459062774625 0.00113506056981396 0.999620365292951 0.999279457952852 0.99982639261309 0.4 0.163364323859513 0.677130233793718 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.37427511018325 0.402405714350099 4.32449790069519 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.774G>A rpoA_c.774G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.780C>A rpoA_c.780C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.780C>T rpoA_c.780C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.783C>T rpoA_c.783C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.792C>G rpoA_c.792C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.798C>T rpoA_c.798C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.801G>A rpoA_c.801G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.804G>T rpoA_c.804G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.6329128986197 0.189104318453829 214.057761575796 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.807G>C rpoA_c.807G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-80T>C rpoA_c.-80T>C 2 upstream_gene_variant 3878587 NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3951 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3317 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.813C>G rpoA_c.813C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.816G>A rpoA_c.816G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.816G>C rpoA_c.816G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.819C>A rpoA_c.819C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.75142405620251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.819C>T rpoA_c.819C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-81G>A rpoA_c.-81G>A 2 upstream_gene_variant 3878588 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 80.2910622977969 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.822A>G rpoA_c.822A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.828G>C rpoA_c.828G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-82A>T rpoA_c.-82A>T 2 upstream_gene_variant 3878589 1 7 0 7 0 8 16810 30524 0 0 0.000219421459229958 0.999737979824446 0.999483781433772 0.999886871715824 0 0 0.369416647552819 0 0 0.409616397225003 0 0 0.369416647552819 0 0 1.26002939553565 0.0561451721436914 146.5 4649 False False 0 0 1.06393155676265 0 0 0.000219421459229958 0.999737979824446 0.999483781433772 0.999886871715824 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 7 11502 23700 0 0 0.000320664925697395 0.999704728561184 0.999391723222185 0.999881277590374 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 1.75031247356753 0.186841449254093 219 3890 False False 0 0 0 0 0 0 0 0 0 1.42986888806462 0 0 0.000320664925697395 0.999704728561184 0.999391723222185 0.999881277590374 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.831G>C rpoA_c.831G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.837C>A rpoA_c.837C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-84_-53delCGAGTACCCCCACCCTCGGGGGCGCCGCCCCC rpoA_c.-84_-53delCGAGTACCCCCACCCTCGGGGGCGCCGCCCCC 2 upstream_gene_variant 3878559 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4000 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3356 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.-84_-83insC rpoA_c.-84_-83insC 2 upstream_gene_variant 3878590 NA 0 0 0 18 0 16792 30532 0.00107079119571683 0.000634738299600123 0.00169178580899694 1 0.999879187193184 1 1 0.814698031862147 1 NA NA NA NA NA NA NA NA NA NA 3940 4649 False False Inf 7.99147236998928 Inf 0 0 0.000219656639819404 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 17 0 11485 23707 0.00147800382542166 0.000861220016155565 0.00236537605429428 1 0.999844409142079 1 1 0.804935677030906 1 NA NA NA NA NA NA NA NA NA NA 3308 3890 False False 0 0 0 0 0 0 0 Inf 8.51620393516598 Inf 0 0 0.000321139494990277 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.843C>G rpoA_c.843C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.849G>A rpoA_c.849G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-84delC rpoA_c.-84delC 2 upstream_gene_variant 3878590 1 12 0 12 23 25 16787 30507 0.00136823319452706 0.000867533996903047 0.00205231857920666 0.999181186951395 0.998791506081474 0.999470039476732 0.479166666666666 0.332866336213668 0.628129832258345 0 0 0.264648469397051 0 0 0.137185171530712 0 0 0.654144006129281 0.00615362061256449 94 4649 False False 1.67191517245487 0.906427335161154 3.07075765897719 0 0 0.000219722057257406 0.999181186951395 0.998791506081474 0.999470039476732 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 12 21 11490 23686 0.0010432968179447 0.000539199208333142 0.00182171963730016 0.999114185683553 0.998646255755329 0.99945158598871 0.363636363636363 0.20400307445512 0.548754644782651 0 0 0.336267116879942 0 0 0.161097615219079 0 0 1.0446158053214 0.0357613279586145 104 3890 False False 0 0 0 0 0 0 0 1.17796841974387 0.528116980555294 2.50775718120304 0 0 0.000320999770035263 0.999114185683553 0.998646255755329 0.99945158598871 4 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.84G>A rpoA_c.84G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.852T>C rpoA_c.852T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.852T>G rpoA_c.852T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-86C>G rpoA_c.-86C>G 2 upstream_gene_variant 3878593 0 0 0 0 9 1 16801 30531 0.000535395597858417 0.000244845253515427 0.00101610321951737 0.999967247478055 0.999817528289014 0.999999170778282 0.9 0.554983882971804 0.997471421455538 NA NA NA 0 0 0.975 NA NA NA NA 3991 4649 False False 16.3549193500386 2.26573473572457 714.408215312578 0 0 0.000219538986540545 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 9 1 11493 23706 0.000782472613458529 0.000357856744032263 0.00148485474620048 0.999957818365883 0.999765001636458 0.999998932054057 0.9 0.554983882971804 0.997471421455538 NA NA NA 0 0 0.975 NA NA NA NA 3349 3890 False False 0 0 0 0 0 0 0 18.5638214565387 2.57162110235215 810.478378810226 0 0 0.000320915993408392 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.870T>C rpoA_c.870T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.882C>T rpoA_c.882C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.888G>A rpoA_c.888G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.894G>A rpoA_c.894G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-89C>A rpoA_c.-89C>A 2 upstream_gene_variant 3878596 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.915C>T rpoA_c.915C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.916C>T rpoA_c.916C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.921A>G rpoA_c.921A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.924C>T rpoA_c.924C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.936G>A rpoA_c.936G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.945C>T rpoA_c.945C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.948C>T rpoA_c.948C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.908144446427509 0.0153974005043644 17.4461131425891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-94C>T rpoA_c.-94C>T 2 upstream_gene_variant 3878601 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3976 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3337 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.-95_-63delGCGCCGCCCCCCGAGTACCCCCACCCTCGGGGG rpoA_c.-95_-63delGCGCCGCCCCCCGAGTACCCCCACCCTCGGGGG 2 upstream_gene_variant 3878569 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4030 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3383 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.951C>G rpoA_c.951C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.951C>T rpoA_c.951C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 7 0 16803 30532 0.000416418798334324 0.000167437820935922 0.000857792460925722 1 0.999879187193184 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 2.61832748907777 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 7 0 11495 23707 0.000608589810467744 0.000244718560881119 0.00125352303681455 1 0.999844409142079 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 2.97179240572548 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.954G>A rpoA_c.954G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.954G>T rpoA_c.954G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-95delG rpoA_c.-95delG 2 upstream_gene_variant 3878601 1 3 0 3 2 10 16808 30522 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999672474780558 0.999397752220648 0.999842928110511 0.166666666666666 0.0208625254600923 0.484137748685967 0 0 0.707598226178713 0 0 0.30849710781876 0 0 4.39506778212465 0.556932551459897 923 4649 False False 0.363184198000951 0.0386890372209022 1.70456922948828 0 0 0.000219447565534303 0.999672474780558 0.999397752220648 0.999842928110511 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 8 11502 23699 0 0 0.000320664925697395 0.999662546927068 0.999335191784523 0.999854300817065 0 0 0.369416647552819 0 0 0.975 0 0 0.369416647552819 0 0 80.2604145666302 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 1.20731769892417 0 0 0.000320664925697395 0.999662546927068 0.999335191784523 0.999854300817065 4 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.960C>G rpoA_c.960C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.960C>T rpoA_c.960C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.963G>A rpoA_c.963G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.963G>T rpoA_c.963G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.966C>A rpoA_c.966C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.972C>T rpoA_c.972C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 31 8 16779 30524 0.00184414039262343 0.00125333722248032 0.00261659758042388 0.999737979824446 0.999483781433772 0.999886871715824 0.794871794871794 0.635355759304881 0.907036072717004 NA NA NA NA NA NA NA NA NA NA NA NA False False 7.04931759938017 3.16839335999889 17.7468336447269 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 26 7 11476 23700 0.00226047643888019 0.00147713322194328 0.00331037981655982 0.999704728561184 0.999391723222185 0.999881277590374 0.787878787878787 0.610919080325886 0.910195755457298 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 7.67066673305781 3.241045456982 20.9327930291593 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.978C>G rpoA_c.978C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.981C>A rpoA_c.981C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.75142405620251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.12235036001139 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.984C>T rpoA_c.984C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.993G>A rpoA_c.993G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.999G>A rpoA_c.999G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.99C>T rpoA_c.99C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoA c.-99G>A rpoA_c.-99G>A 2 upstream_gene_variant 3878606 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA c.-9A>C rpoA_c.-9A>C 2 upstream_gene_variant 3878516 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Ala107Ser rpoA_p.Ala107Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4038 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3390 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Ala107Thr rpoA_p.Ala107Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4061 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3409 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Ala180Gly rpoA_p.Ala180Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3959 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3324 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Ala180Thr rpoA_p.Ala180Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3981 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3342 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Ala180Val rpoA_p.Ala180Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 32 0 16778 30532 0.00190362879238548 0.0013024338261299 0.00268630258659741 1 0.999879187193184 1 1 0.891118839320647 1 NA NA NA NA NA NA NA NA NA NA 4031 4649 False False Inf 14.8910918616325 Inf 0 0 0.000219839906889832 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 22 0 11480 23707 0.00191271083289862 0.00119906180010764 0.00289444346770694 1 0.999844409142079 1 1 0.845627487184425 1 NA NA NA NA NA NA NA NA NA NA 3384 3890 False False 0 0 0 0 0 0 0 Inf 11.3088830935203 Inf 0 0 0.000321279341637369 1 0.999844409142079 1 3 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Ala207Val rpoA_p.Ala207Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4062 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3410 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Ala222Val rpoA_p.Ala222Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Ala229Val rpoA_p.Ala229Val 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4083 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Ala239Val rpoA_p.Ala239Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 0.5 0.012579117093425 0.987420882906574 0.333333333333333 0.00840375865961264 0.905700675949754 1.81628889285501 0.0231368832357927 142.421067027342 1 1627.5 4649 False False 0.908144446427509 0.0153974005043644 17.4461131425891 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 0.5 0.012579117093425 0.987420882906574 0.333333333333333 0.00840375865961264 0.905700675949754 2.06112511955482 0.02625506025566 161.594871509457 0.546656008695984 370.5 3890 False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Ala241Asp rpoA_p.Ala241Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Ala245Glu rpoA_p.Ala245Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4010 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3365 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Ala245Val rpoA_p.Ala245Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 3 7 16807 30525 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.99977073234639 0.999527678427408 0.999907817703152 0.3 0.0667395111777345 0.652452850059997 0 0 0.409616397225003 0 0 0.409616397225003 0 0 1.26029561899355 0.056162143631628 166 4649 False False 0.778374656818162 0.129888199762363 3.41016225344332 0 0 0.000219460621016169 0.99977073234639 0.999527678427408 0.999907817703152 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 2 4 11500 23703 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999831273463534 0.999568049920357 0.99995402584539 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12289352368013 0.310805712195535 291 3890 False False 0 0 0 0 0 0 0 1.0305652173913 0.0931903474189042 7.19201282268065 0 0 0.000320720684566658 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Ala248Val rpoA_p.Ala248Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Ala321Ser rpoA_p.Ala321Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 2 2 16808 30530 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999934494956111 0.999763393503742 0.99999206693684 0.5 0.067585986488543 0.932414013511457 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.67174719181657 0.54201215115422 740.5 4649 False False 1.8163969538315 0.131636449523742 25.0652602654423 0 0 0.000219447565534303 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 80.2980353694986 1 1214.5 3890 False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 0 0 0.000320720684566658 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Ala321Val rpoA_p.Ala321Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Arg153Trp rpoA_p.Arg153Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 22 0 22 4 32 16806 30500 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.998951919297786 0.998520742016693 0.999283006561325 0.111111111111111 0.0311161399450152 0.260610920510829 0 0 0.154372512815574 0 0 0.108881160679352 0 0 0.331364062341461 7.56558196529746e-05 45 4649 True False 0.226853504700702 0.0582495969465151 0.63984209006415 0 0 0.000219473678051534 0.998951919297786 0.998520742016693 0.999283006561325 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 16 0 16 3 22 11499 23685 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.999072004049436 0.998595338091004 0.999418341378366 0.12 0.0254653966477332 0.312190307286235 0 0 0.205907214207822 0 0 0.154372512815574 0 0 0.534203732157277 0.00242426033717556 60 3890 False False 0 0 0 0 0 0 0 0.280874226217299 0.0538186161634964 0.935210098982478 0 0 0.000320748571273651 0.999072004049436 0.998595338091004 0.999418341378366 3 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Arg161Cys rpoA_p.Arg161Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4046 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3396 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Arg182Gln rpoA_p.Arg182Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3986 4649 False False Inf 1.1990579265185 Inf 0 0 0.000219473678051534 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Arg182Leu rpoA_p.Arg182Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 17 0 16793 30532 0.00101130279595478 0.000589228022589122 0.0016187015795436 1 0.999879187193184 1 1 0.804935677030906 1 NA NA NA NA NA NA NA NA NA NA 3935 4649 False False Inf 7.50125453808733 Inf 0 0 0.000219643561005912 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 11 0 11491 23707 0.000956355416449313 0.000477502787107626 0.00171053820723243 1 0.999844409142079 1 1 0.715085847081845 1 NA NA NA NA NA NA NA NA NA NA 3303 3890 False False 0 0 0 0 0 0 0 Inf 5.1761760609822 Inf 0 0 0.000320971839633333 1 0.999844409142079 1 4 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Arg182Trp rpoA_p.Arg182Trp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 5 0 16805 30532 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 1 0.999879187193184 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 4005 4649 False False Inf 1.66460481015123 Inf 0 0 0.000219486736640675 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3360 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 2 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Arg186Leu rpoA_p.Arg186Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4020 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Arg223Gln rpoA_p.Arg223Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Arg278Cys rpoA_p.Arg278Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4016 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3369 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Arg55Ser rpoA_p.Arg55Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Asn129Ser rpoA_p.Asn129Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4006 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3361 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Asn36Ser rpoA_p.Asn36Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Asn79His rpoA_p.Asn79His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4084 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3430 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Asp109Asn rpoA_p.Asp109Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3952 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Asp165Glu rpoA_p.Asp165Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4007 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3362 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Asp179Ala rpoA_p.Asp179Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3960 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3325 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Asp179Glu rpoA_p.Asp179Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3977 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3338 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Asp190Ala rpoA_p.Asp190Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3932 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3301 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Asp190Gly rpoA_p.Asp190Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 13 0 16797 30532 0.000773349196906603 0.000411838091387593 0.00132208760075144 1 0.999879187193184 1 1 0.752947361999529 1 NA NA NA NA NA NA NA NA NA NA 4017 4649 False False Inf 5.53887003766597 Inf 0 0 0.000219591261323031 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 7 0 11495 23707 0.000608589810467744 0.000244718560881119 0.00125352303681455 1 0.999844409142079 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 3370 3890 False False 0 0 0 0 0 0 0 Inf 2.97179240572548 Inf 0 0 0.000320860166613556 1 0.999844409142079 1 4 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Asp195Glu rpoA_p.Asp195Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Asp252Asn rpoA_p.Asp252Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3992 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3350 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Asp253Ala rpoA_p.Asp253Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3431 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 1 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Asp253Asn rpoA_p.Asp253Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 3 8 16807 30524 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999737979824446 0.999483781433772 0.999886871715824 0.272727272727272 0.0602177341729066 0.609742559572421 0 0 0.369416647552819 0 0 0.369416647552819 0 0 1.06412147880545 0.0571705225378867 172 4649 False False 0.681055512584042 0.116357116142111 2.83809201170135 0 0 0.000219460621016169 0.999737979824446 0.999483781433772 0.999886871715824 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 3 8 11499 23699 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.999662546927068 0.999335191784523 0.999854300817065 0.272727272727272 0.0602177341729066 0.609742559572421 0 0 0.369416647552819 0 0 0.369416647552819 0 0 1.20763271838112 0.0599279528154425 121 3890 False False 0 0 0 0 0 0 0 0.772860683537698 0.132058090819728 3.22064246074135 0 0 0.000320748571273651 0.999662546927068 0.999335191784523 0.999854300817065 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Asp253Gly rpoA_p.Asp253Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 13 1 16797 30531 0.000773349196906603 0.000411838091387593 0.00132208760075144 0.999967247478055 0.999817528289014 0.999999170778282 0.928571428571428 0.661315510068178 0.998193219340874 NA NA NA 0 0 0.975 NA NA NA NA 4039 4649 False False 23.6293981068047 3.54819873645803 999.432079931171 0 0 0.000219591261323031 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 6 1 11496 23706 0.000521648408972352 0.000191459062774625 0.00113506056981396 0.999957818365883 0.999765001636458 0.999998932054057 0.857142857142857 0.421276802956804 0.996389703138099 NA NA NA 0 0 0.975 NA NA NA NA 3391 3890 False False 0 0 0 0 0 0 0 12.3726513569937 1.50072525153826 567.507166587209 0 0 0.000320832260499258 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Asp253Tyr rpoA_p.Asp253Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Asp310Ala rpoA_p.Asp310Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4033 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3386 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Asp337Tyr rpoA_p.Asp337Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Gln151Pro rpoA_p.Gln151Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3978 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3339 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Gln185Arg rpoA_p.Gln185Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3961 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3326 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Gln185Leu rpoA_p.Gln185Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3979 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3340 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Gln185Lys rpoA_p.Gln185Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3980 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3341 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Gln5Arg rpoA_p.Gln5Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Gln5His rpoA_p.Gln5His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Glu104Ala rpoA_p.Glu104Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4043 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3394 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Glu104Lys rpoA_p.Glu104Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Glu137Gly rpoA_p.Glu137Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 6 0 16804 30532 0.000356930398572278 0.000130998068917797 0.000776724091447791 1 0.999879187193184 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 3987 4649 False False Inf 2.13890645017026 Inf 0 0 0.000219499796783869 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3345 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Glu184Asp rpoA_p.Glu184Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 81 0 16729 30532 0.00481856038072575 0.00382841930617058 0.005985522878 1 0.999879187193184 1 1 0.955479737543678 1 NA NA NA NA NA NA NA NA NA NA 3953 4649 False False Inf 39.1502270867533 Inf 0 0 0.000220483756959041 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 76 0 11426 23707 0.0066075465136498 0.00520942439563912 0.00826344670543621 1 0.999844409142079 1 1 0.952621246133069 1 NA NA NA NA NA NA NA NA NA NA 3318 3890 False False 0 0 0 0 0 0 0 Inf 41.6924224808634 Inf 0 0 0.000322797483071588 1 0.999844409142079 1 4 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Glu184Gly rpoA_p.Glu184Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Glu197Ala rpoA_p.Glu197Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Glu197Gln rpoA_p.Glu197Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3962 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3327 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Glu197Lys rpoA_p.Glu197Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Glu24Gly rpoA_p.Glu24Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Glu24Lys rpoA_p.Glu24Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4008 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3363 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Glu274Gly rpoA_p.Glu274Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4077 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3425 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 2 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Glu319Lys rpoA_p.Glu319Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 95 474 16715 30058 0.0056513979773944 0.00457465358246265 0.00690419431864486 0.984475304598454 0.983025187211458 0.985832143961325 0.166959578207381 0.137232650889066 0.200192402334178 NA NA NA 0 0 0.0077522412786346 NA NA NA NA NA NA False True 0.360411767898411 0.285821521274396 0.450508530350692 0 0 0.000220668407392531 0.984475304598454 0.983025187211458 0.985832143961325 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 75 412 11427 23295 0.0065206051121544 0.00513222272131632 0.00816687241181501 0.982621166743999 0.980876177242801 0.984246351815818 0.15400410677618 0.123101818321425 0.189177623585592 NA NA NA 0 0 0.00891362687577546 NA NA NA NA NA NA False True 0 1 1 0 0 1 1 0.371103059437663 0.285905129120659 0.476178505479699 0 0 0.000322769238967019 0.982621166743999 0.980876177242801 0.984246351815818 33 Not assoc w R 5) Not assoc w R No change yes 1 +Rifampicin rpoA p.Glu338Asp rpoA_p.Glu338Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Glu345Asp rpoA_p.Glu345Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Glu75Asp rpoA_p.Glu75Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 2 5 16808 30527 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999836237390279 0.999617874429585 0.999946824656822 0.285714285714285 0.0366925661760855 0.709579136262657 0 0 0.707598226178713 0 0 0.521823750104981 0 0 4.39578789664168 0.556927817140462 802.5 4649 False False 0.726487386958591 0.069161301215026 4.43811993507661 0 0 0.000219447565534303 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 5 11501 23702 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999789091829417 0.999507879904061 0.999931515258336 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.707598226178713 0 0 0.521823750104981 0 0 4.98826115735512 0.555670231197011 458.5 3890 False False 0 0 0 0 0 0 0 0.412172854534388 0.00871781959321125 3.68423590106777 0 0 0.000320692802708327 0.999789091829417 0.999507879904061 0.999931515258336 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Glu89Gln rpoA_p.Glu89Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 10 0 10 1 11 16809 30521 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999639722258614 0.999355455254591 0.999820137367966 0.0833333333333333 0.00210759323186022 0.384796165150944 0 0 0.30849710781876 0 0 0.284914152918154 0 0 0.810184487167463 0.0177771651961481 121 4649 False False 0.165068496855039 0.00383877950020004 1.13592616933053 0 0 0.000219434511605659 0.999639722258614 0.999355455254591 0.999820137367966 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 0 8 11502 23699 0 0 0.000320664925697395 0.999662546927068 0.999335191784523 0.999854300817065 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 1.20731769892417 0.0599154010311281 117.5 3890 False False 0 0 0 0 0 0 0 0 0 1.20731769892417 0 0 0.000320664925697395 0.999662546927068 0.999335191784523 0.999854300817065 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Gly103Ala rpoA_p.Gly103Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Gly103Ser rpoA_p.Gly103Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Gly108Ser rpoA_p.Gly108Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Gly115Ala rpoA_p.Gly115Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4063 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Gly122Asp rpoA_p.Gly122Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Gly132Asp rpoA_p.Gly132Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3970 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3333 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Gly160Glu rpoA_p.Gly160Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Gly220Cys rpoA_p.Gly220Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3963 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3328 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Gly220Ser rpoA_p.Gly220Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3946 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3313 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Gly273Ser rpoA_p.Gly273Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.9820231071276 0.168448731581911 252 4649 False False 0 0 1.9820231071276 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 2.24912710990902 0.180424970179968 177 3890 False False 0 0 0 0 0 0 0 0 0 2.24912710990902 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Gly305Ala rpoA_p.Gly305Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Gly31Ala rpoA_p.Gly31Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 33 0 16777 30532 0.00196311719214753 0.00135169297871974 0.00275585192368924 1 0.999879187193184 1 1 0.89423718992542 1 NA NA NA NA NA NA NA NA NA NA 4055 4649 False False Inf 15.3840150429545 Inf 0 0 0.00021985300909755 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 27 0 11475 23707 0.00234741784037558 0.0015475155067352 0.00341354562468017 1 0.999844409142079 1 1 0.872297132384567 1 NA NA NA NA NA NA NA NA NA NA 3403 3890 False False 0 0 0 0 0 0 0 Inf 14.1098640767962 Inf 0 0 0.000321419310135588 1 0.999844409142079 1 8 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Gly31Cys rpoA_p.Gly31Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3954 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3319 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Gly31Ser rpoA_p.Gly31Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 43 0 16767 30532 0.00255800118976799 0.00185183780155513 0.00344408115441007 1 0.999879187193184 1 1 0.917788878845861 1 NA NA NA NA NA NA NA NA NA NA 4078 4649 False False Inf 20.3218622729967 Inf 0 0 0.000219984117122384 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 33 0 11469 23707 0.00286906624934793 0.00197573107651826 0.0040268977332274 1 0.999844409142079 1 1 0.89423718992542 1 NA NA NA NA NA NA NA NA NA NA 3426 3890 False False 0 0 0 0 0 0 0 Inf 17.4722896658069 Inf 0 0 0.000321587433401291 1 0.999844409142079 1 9 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Gly334Asp rpoA_p.Gly334Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Gly58Arg rpoA_p.Gly58Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Gly58Ser rpoA_p.Gly58Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Gly68Arg rpoA_p.Gly68Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4001 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3357 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.His119Arg rpoA_p.His119Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4074 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3422 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.His119Tyr rpoA_p.His119Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.His124Tyr rpoA_p.His124Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 70.7668929171829 1 1627.5 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 0 0 0.000219447565534303 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 80.2980353694986 1 1214.5 3890 False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 0 0 0.000320720684566658 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.His243Gln rpoA_p.His243Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.His302Arg rpoA_p.His302Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.His302Tyr rpoA_p.His302Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3988 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3346 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Ile125Val rpoA_p.Ile125Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 7 16810 30525 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 1.54246355322091 0.0957757853990922 188.5 4649 False False 0 0 1.26007067420399 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 7 11502 23700 0 0 0.000320664925697395 0.999704728561184 0.999391723222185 0.999881277590374 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 1.75031247356753 0.186841449254093 219 3890 False False 0 0 0 0 0 0 0 0 0 1.42986888806462 0 0 0.000320664925697395 0.999704728561184 0.999391723222185 0.999881277590374 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Ile193Leu rpoA_p.Ile193Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3936 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3304 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Ile193Val rpoA_p.Ile193Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4056 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3404 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Ile244Val rpoA_p.Ile244Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Ile294Val rpoA_p.Ile294Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Ile3Val rpoA_p.Ile3Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4048 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Leu138Phe rpoA_p.Leu138Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Leu14Val rpoA_p.Leu14Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Leu249Arg rpoA_p.Leu249Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Leu306Met rpoA_p.Leu306Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4079 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3427 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Leu306Val rpoA_p.Leu306Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Leu308Phe rpoA_p.Leu308Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 11 5 16799 30527 0.00065437239738251 0.000326704163498642 0.00117055062018267 0.999836237390279 0.999617874429585 0.999946824656822 0.6875 0.413379363548641 0.889830045282882 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.9833210467949 0.168491929283305 282 4649 False False 3.99782129888683 1.28021914521895 14.6804531160199 0 0 0.000219565120820351 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 11 5 11491 23702 0.000956355416449313 0.000477502787107626 0.00171053820723243 0.999789091829417 0.999507879904061 0.999931515258336 0.6875 0.413379363548641 0.889830045282882 0 0 0.521823750104981 0 0 0.521823750104981 0 0 2.2512837148129 0.180542639363781 200 3890 False False 0 0 0 0 0 0 0 4.53784701070402 1.45302913764864 16.6635345475112 0 0 0.000320971839633333 0.999789091829417 0.999507879904061 0.999931515258336 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Leu347Phe rpoA_p.Leu347Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4049 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3397 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Leu80Phe rpoA_p.Leu80Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Leu80Val rpoA_p.Leu80Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 4 15 16806 30517 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999508712170837 0.99918982468991 0.9997250046892 0.210526315789473 0.0605245377092897 0.455653081891505 NA NA NA 0 0 0.218019360910534 NA NA NA NA 4070 4649 False False 0.484223888293863 0.116963432612523 1.52031868162699 0 0 0.000219473678051534 0.999508712170837 0.99918982468991 0.9997250046892 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 4 12 11498 23695 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 0.999493820390602 0.999115973206486 0.999738423129043 0.25 0.0726620382528822 0.523770819896127 NA NA NA 0 0 0.264648469397051 NA NA NA NA 3418 3890 False False 0 0 0 0 0 0 0 0.686931060474285 0.161439362184139 2.26718009246751 0 0 0.000320776462830572 0.999493820390602 0.999115973206486 0.999738423129043 2 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Lys177Asn rpoA_p.Lys177Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4050 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3398 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Lys191Thr rpoA_p.Lys191Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4051 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3399 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Lys199Asn rpoA_p.Lys199Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Lys298Thr rpoA_p.Lys298Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Lys300Met rpoA_p.Lys300Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Lys81Thr rpoA_p.Lys81Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Lys99Arg rpoA_p.Lys99Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4085 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Met123Leu rpoA_p.Met123Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Met95Val rpoA_p.Met95Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Phe63Cys rpoA_p.Phe63Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4064 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3411 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Pro113Ser rpoA_p.Pro113Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Pro121Arg rpoA_p.Pro121Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 16809 30529 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999901742434167 0.999712876815577 0.99997973646933 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.39581433818102 0.556927644280045 795 4649 False False 0.605409800305391 0.0115361654751757 7.54087213596152 0 0 0.000219434511605659 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 80.2910622977969 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Pro121Leu rpoA_p.Pro121Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3971 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Pro121Ser rpoA_p.Pro121Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 9.67028206568003 0.541992006917746 476.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 10.9713274274722 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Pro148Leu rpoA_p.Pro148Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3373 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Pro238Leu rpoA_p.Pro238Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4086 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3432 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Pro238Ser rpoA_p.Pro238Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4028 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3381 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Pro250Leu rpoA_p.Pro250Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 2 2 16808 30530 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999934494956111 0.999763393503742 0.99999206693684 0.5 0.067585986488543 0.932414013511457 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.908198476915754 0.0153983161756435 17.447151037868 1 1627.5 4649 False False 1.8163969538315 0.131636449523742 25.0652602654423 5.94919388422868e-05 1.50620434989522e-06 0.000331422795737767 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Pro250Ser rpoA_p.Pro250Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 9.66996583219897 0.541987658825864 457.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 80.2773259044493 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Pro250Thr rpoA_p.Pro250Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Pro25Arg rpoA_p.Pro25Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 18 0 16792 30532 0.00107079119571683 0.000634738299600123 0.00169178580899694 1 0.999879187193184 1 1 0.814698031862147 1 NA NA NA NA NA NA NA NA NA NA 3941 4649 False False Inf 7.99147236998928 Inf 0 0 0.000219656639819404 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 17 0 11485 23707 0.00147800382542166 0.000861220016155565 0.00236537605429428 1 0.999844409142079 1 1 0.804935677030906 1 NA NA NA NA NA NA NA NA NA NA 3309 3890 False False 0 0 0 0 0 0 0 Inf 8.51620393516598 Inf 0 0 0.000321139494990277 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Pro25Gln rpoA_p.Pro25Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3966 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3330 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Pro28Leu rpoA_p.Pro28Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3972 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Pro28Ser rpoA_p.Pro28Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3967 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3331 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Pro312Thr rpoA_p.Pro312Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3964 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Pro313Arg rpoA_p.Pro313Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Pro313Leu rpoA_p.Pro313Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Pro313Ser rpoA_p.Pro313Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Pro313Thr rpoA_p.Pro313Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4065 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3412 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Pro92Ser rpoA_p.Pro92Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3933 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3302 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Ser10Phe rpoA_p.Ser10Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3973 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3334 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Ser155Leu rpoA_p.Ser155Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Ser203Arg rpoA_p.Ser203Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Ser203Ile rpoA_p.Ser203Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3982 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Ser307Leu rpoA_p.Ser307Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 5 16809 30527 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999836237390279 0.999617874429585 0.999946824656822 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.841886116991581 0 0 0.521823750104981 0 0 9.67022395468835 0.541991207287615 463 4649 False False 0.363222083407698 0.00768325476784986 3.24674897733262 0 0 0.000219434511605659 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 0 0 0.841886116991581 0 0 0.521823750104981 0 0 10.970403447915 1 504 3890 False False 0 0 0 0 0 0 0 0 0 2.24912710990902 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 1 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Ser318Leu rpoA_p.Ser318Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Ser331Trp rpoA_p.Ser331Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Ser53Gly rpoA_p.Ser53Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 5 1 16805 30531 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 0.999967247478055 0.999817528289014 0.999999170778282 0.833333333333333 0.358765421002325 0.99578925548551 0 0 0.975 0 0 0.975 0 0 70.7795121310531 1 1627.5 4649 False False 9.08390360011901 1.01631102884943 428.726615606949 0 0 0.000219486736640675 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 5 1 11497 23706 0.00043470700747696 0.000141162766530747 0.00101416710312943 0.999957818365883 0.999765001636458 0.999998932054057 0.833333333333333 0.358765421002325 0.99578925548551 0 0 0.975 0 0 0.975 0 0 80.3189618536173 1 1214.5 3890 False False 0 0 0 0 0 0 0 10.3096459946072 1.15337945963023 486.419600220716 0 0 0.000320804359238686 0.999957818365883 0.999765001636458 0.999998932054057 3 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Ser82Asn rpoA_p.Ser82Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Ser86Tyr rpoA_p.Ser86Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Thr117Ile rpoA_p.Thr117Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3983 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3343 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Thr127Ala rpoA_p.Thr127Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 9 0 9 3 18 16807 30514 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999410454605004 0.999068423526975 0.999650561796013 0.142857142857142 0.0304889676215155 0.363423987016981 0 0 0.336267116879942 0 0 0.185301968137852 0 0 0.919971062149442 0.0314959392885258 127 4649 False False 0.302592173895797 0.0570930355428442 1.03674460439863 0 0 0.000219460621016169 0.999410454605004 0.999068423526975 0.999650561796013 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 1 9 11501 23698 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999620365292951 0.999279457952852 0.99982639261309 0.1 0.00252857854446178 0.445016117028195 0 0 0.521823750104981 0 0 0.336267116879942 0 0 2.2489428319637 0.180414923969718 166 3890 False False 0 0 0 0 0 0 0 0.228946275203122 0.00522688682241855 1.65262624160018 0 0 0.000320692802708327 0.999620365292951 0.999279457952852 0.99982639261309 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Thr127Met rpoA_p.Thr127Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Thr175Ala rpoA_p.Thr175Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3993 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3351 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Thr181Ala rpoA_p.Thr181Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 10 0 16800 30532 0.000594883997620464 0.000285305684944214 0.00109373983334496 1 0.999879187193184 1 1 0.691502892181239 1 NA NA NA NA NA NA NA NA NA NA 4066 4649 False False Inf 4.07313735951873 Inf 0 0 0.000219552052902727 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 6 0 11496 23707 0.000521648408972352 0.000191459062774625 0.00113506056981396 1 0.999844409142079 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 3413 3890 False False 0 0 0 0 0 0 0 Inf 2.42738974088595 Inf 0 0 0.000320832260499258 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Thr181Ile rpoA_p.Thr181Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3947 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3314 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Thr181Ser rpoA_p.Thr181Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4009 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3364 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Thr187Ala rpoA_p.Thr187Ala 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 147 0 16663 30532 0.00874479476502082 0.00739311776297434 0.0102703083234345 1 0.999879187193184 1 1 0.975217829510419 1 NA NA NA NA NA NA NA NA NA NA 4024 4649 False False Inf 72.1251538952279 Inf 0 0 0.000221356968100813 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 116 0 11386 23707 0.0100852025734654 0.00834055624587913 0.0120840550865369 1 0.999844409142079 1 1 0.96869963925671 1 NA NA NA NA NA NA NA NA NA NA 3377 3890 False False 0 0 0 0 0 0 0 Inf 64.3116885484972 Inf 0 0 0.000323931314778346 1 0.999844409142079 1 54 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Thr187Asn rpoA_p.Thr187Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4080 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Thr187Pro rpoA_p.Thr187Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 8 0 16802 30532 0.000475907198096371 0.00020548462525215 0.000937510381255989 1 0.999879187193184 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 3948 4649 False False Inf 3.10133467016734 Inf 0 0 0.000219525921733526 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 11498 23707 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 1 0.999844409142079 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3315 3890 False False 0 0 0 0 0 0 0 Inf 1.3608069907404 Inf 0 0 0.000320776462830572 1 0.999844409142079 1 4 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Thr187Ser rpoA_p.Thr187Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3949 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Thr214Met rpoA_p.Thr214Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3994 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Thr271Ile rpoA_p.Thr271Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 4 23 16806 30509 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999246691995283 0.998869881214224 0.999522409302755 0.148148148148148 0.0418873964737672 0.337310864024244 NA NA NA 0 0 0.148185128915224 NA NA NA NA 3937 4649 False False 0.315715401849236 0.0793669128942507 0.924261287209764 0 0 0.000219473678051534 0.999246691995283 0.998869881214224 0.999522409302755 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 3 20 11499 23687 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.99915636731767 0.998697376967606 0.99948461349205 0.130434782608695 0.0277515074227932 0.335889137537121 NA NA NA 0 0 0.168433470983085 NA NA NA NA 3305 3890 False False 0 0 0 0 0 0 0 0.308987738064179 0.0587922487183818 1.04218833432732 0 0 0.000320748571273651 0.99915636731767 0.998697376967606 0.99948461349205 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Thr332Ala rpoA_p.Thr332Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Thr33Pro rpoA_p.Thr33Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4052 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3400 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Thr8Ser rpoA_p.Thr8Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4081 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3428 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Tyr336His rpoA_p.Tyr336His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Val183Ala rpoA_p.Val183Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 26 0 16784 30532 0.0015466983938132 0.00101059577405045 0.00226545603351431 1 0.999879187193184 1 1 0.867725395502245 1 NA NA NA NA NA NA NA NA NA NA 3938 4649 False False Inf 11.9323359519505 Inf 0 0 0.000219761326426665 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 22 0 11480 23707 0.00191271083289862 0.00119906180010764 0.00289444346770694 1 0.999844409142079 1 1 0.845627487184425 1 NA NA NA NA NA NA NA NA NA NA 3306 3890 False False 0 0 0 0 0 0 0 Inf 11.3088830935203 Inf 0 0 0.000321279341637369 1 0.999844409142079 1 5 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Val183Gly rpoA_p.Val183Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 65 0 16745 30532 0.00386674598453301 0.00298550248723015 0.00492586728145316 1 0.999879187193184 1 1 0.944828365681186 1 NA NA NA NA NA NA NA NA NA NA 4071 4649 False False Inf 31.1911856882343 Inf 0 0 0.000220273105925916 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 38 0 11464 23707 0.0033037732568249 0.0023389751642717 0.00453189495926602 1 0.999844409142079 1 1 0.907487238584121 1 NA NA NA NA NA NA NA NA NA NA 3419 3890 False False 0 0 0 0 0 0 0 Inf 20.2764910499709 Inf 0 0 0.000321727670533211 1 0.999844409142079 1 14 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Val183Ile rpoA_p.Val183Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3939 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3307 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Val183Leu rpoA_p.Val183Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4034 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Val258Met rpoA_p.Val258Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Val297Leu rpoA_p.Val297Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Val66Ala rpoA_p.Val66Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3984 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Val66Leu rpoA_p.Val66Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Val69Leu rpoA_p.Val69Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4011 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3366 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoA p.Val73Ile rpoA_p.Val73Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoA p.Val85Leu rpoA_p.Val85Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.1002C>T rpoB_c.1002C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1020C>G rpoB_c.1020C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1024T>C rpoB_c.1024T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1035T>C rpoB_c.1035T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.341150751115529 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1035T>G rpoB_c.1035T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1038G>A rpoB_c.1038G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1050C>G rpoB_c.1050C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1050C>T rpoB_c.1050C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 7 16810 30525 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.26007067420399 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 7 11502 23700 0 0 0.000320664925697395 0.999704728561184 0.999391723222185 0.999881277590374 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.42986888806462 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1056G>C rpoB_c.1056G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1059C>T rpoB_c.1059C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 5 16809 30527 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999836237390279 0.999617874429585 0.999946824656822 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.363222083407698 0.00768325476784986 3.24674897733262 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 4 11501 23703 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999831273463534 0.999568049920357 0.99995402584539 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.515237805408225 0.0104655802548345 5.20753049950472 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-106A>G rpoB_c.-106A>G 1 upstream_gene_variant 759701 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.1083C>G rpoB_c.1083C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1083C>T rpoB_c.1083C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1086C>T rpoB_c.1086C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1089C>T rpoB_c.1089C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.108T>A rpoB_c.108T>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1104C>T rpoB_c.1104C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-110A>G rpoB_c.-110A>G 1 upstream_gene_variant 759697 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.1110C>T rpoB_c.1110C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1122G>C rpoB_c.1122G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-112G>A rpoB_c.-112G>A 1 upstream_gene_variant 759695 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2772 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2313 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB c.1134G>T rpoB_c.1134G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.341150751115529 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1137C>T rpoB_c.1137C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-113C>T rpoB_c.-113C>T 1 upstream_gene_variant 759694 1 6 0 6 7 6 16803 30526 0.000416418798334324 0.000167437820935922 0.000857792460925722 0.999803484868334 0.999572318737888 0.999927879105266 0.538461538461538 0.251345482270303 0.807767558198712 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.54315671442428 0.0958130451724107 211 4649 False False 2.11948263206967 0.609804388621839 7.63501040266725 0 0 0.000219512858481393 0.999803484868334 0.999572318737888 0.999927879105266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 2 5 11500 23702 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999789091829417 0.999507879904061 0.999931515258336 0.285714285714285 0.0366925661760855 0.709579136262657 0 0 0.521823750104981 0 0 0.521823750104981 0 0 2.24951890955832 0.18044632709958 195.5 3890 False False 0 0 0 0 0 0 0 0.824417391304347 0.0784856369585262 5.0365353499031 0 0 0.000320720684566658 0.999789091829417 0.999507879904061 0.999931515258336 3 3) Uncertain significance No change no 1 +Rifampicin rpoB c.1140A>G rpoB_c.1140A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.114G>A rpoB_c.114G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 3 1 16807 30531 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999967247478055 0.999817528289014 0.999999170778282 0.75 0.194120449683243 0.99369053679029 NA NA NA NA NA NA NA NA NA NA NA NA False False 5.44969358005592 0.437509494081317 285.652299683162 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.114G>C rpoB_c.114G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1155C>G rpoB_c.1155C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1158C>G rpoB_c.1158C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-115delT rpoB_c.-115delT 1 upstream_gene_variant 759691 0 0 0 0 7 0 16803 30532 0.000416418798334324 0.000167437820935922 0.000857792460925722 1 0.999879187193184 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 2372 4649 False False Inf 2.61832748907777 Inf 0 0 0.000219512858481393 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB c.1164G>C rpoB_c.1164G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1167G>A rpoB_c.1167G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1167G>T rpoB_c.1167G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1176G>C rpoB_c.1176G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1179G>C rpoB_c.1179G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.117C>T rpoB_c.117C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-117G>A rpoB_c.-117G>A 1 upstream_gene_variant 759690 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.1182C>G rpoB_c.1182C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1185G>T rpoB_c.1185G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1188G>A rpoB_c.1188G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1191G>C rpoB_c.1191G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1200C>G rpoB_c.1200C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1206C>T rpoB_c.1206C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1209G>C rpoB_c.1209G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 2 16808 30530 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999934494956111 0.999763393503742 0.99999206693684 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.8163969538315 0.131636449523742 25.0652602654423 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 2 11500 23705 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999915636731767 0.999695284447545 0.999989783053538 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06130434782608 0.149383229063395 28.4413197127326 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-121_-120insT rpoB_c.-121_-120insT 1 upstream_gene_variant 759686 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.1221A>C rpoB_c.1221A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1221A>G rpoB_c.1221A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.908144446427509 0.0153974005043644 17.4461131425891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1224G>A rpoB_c.1224G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-122C>T rpoB_c.-122C>T 1 upstream_gene_variant 759685 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.1230G>C rpoB_c.1230G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 1 16807 30531 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999967247478055 0.999817528289014 0.999999170778282 0.75 0.194120449683243 0.99369053679029 NA NA NA NA NA NA NA NA NA NA NA NA False False 5.44969358005592 0.437509494081317 285.652299683162 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 1 11499 23706 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.999957818365883 0.999765001636458 0.999998932054057 0.75 0.194120449683243 0.99369053679029 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 6.18471171406209 0.496496186771195 324.103527365594 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1230G>T rpoB_c.1230G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1231T>C rpoB_c.1231T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 2 16807 30530 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999934494956111 0.999763393503742 0.99999206693684 0.6 0.146632799634673 0.947255049473683 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.72475754150056 0.312074221533576 32.6324551811023 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 2 11499 23705 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.999915636731767 0.999695284447545 0.999989783053538 0.6 0.146632799634673 0.947255049473683 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.09222541090529 0.354154889835857 37.0377673791385 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1233G>A rpoB_c.1233G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1242C>T rpoB_c.1242C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 7 16810 30525 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.26007067420399 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1245G>C rpoB_c.1245G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1245G>T rpoB_c.1245G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1248G>C rpoB_c.1248G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1251G>C rpoB_c.1251G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.6329128986197 0.189104318453829 214.057761575796 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1254C>G rpoB_c.1254C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1254C>T rpoB_c.1254C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.750576632084797 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1257C>G rpoB_c.1257C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1263C>T rpoB_c.1263C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-126C>G rpoB_c.-126C>G 1 upstream_gene_variant 759681 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.1275C>T rpoB_c.1275C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1278C>A rpoB_c.1278C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1278C>T rpoB_c.1278C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-127G>A rpoB_c.-127G>A 1 upstream_gene_variant 759680 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.1281C>T rpoB_c.1281C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1284C>T rpoB_c.1284C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 4 1 16806 30531 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999967247478055 0.999817528289014 0.999999170778282 0.8 0.28358206388191 0.994949236620532 NA NA NA NA NA NA NA NA NA NA NA NA False False 7.26669046769011 0.71899465830523 357.208630433948 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 4 1 11498 23706 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 0.999957818365883 0.999765001636458 0.999998932054057 0.8 0.28358206388191 0.994949236620532 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 8.24699947817011 0.815939832795188 405.284913246419 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1287G>A rpoB_c.1287G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1288C>T rpoB_c.1288C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1291_1296delAGCCAAinsTCGCAG rpoB_c.1291_1296delAGCCAAinsTCGCAG 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.6329128986197 0.189104318453829 214.057761575796 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1299C>T rpoB_c.1299C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 15 16809 30517 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999508712170837 0.99918982468991 0.9997250046892 0.0625 0.00158111172276588 0.302320738434531 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.121034366510004 0.0028790007379686 0.786861037880772 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 10 11502 23697 0 0 0.000320664925697395 0.999578183658835 0.999224402000993 0.999797704727851 0 0 0.30849710781876 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.919347572200535 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.12C>T rpoB_c.12C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 9 16810 30523 0 0 0.000219421459229958 0.999705227302502 0.999440503684993 0.999865202576615 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.920078094923294 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 7 11502 23700 0 0 0.000320664925697395 0.999704728561184 0.999391723222185 0.999881277590374 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.42986888806462 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1305C>T rpoB_c.1305C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1320G>T rpoB_c.1320G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.9820231071276 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.24912710990902 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1323G>C rpoB_c.1323G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1326G>C rpoB_c.1326G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1326G>T rpoB_c.1326G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 3 16809 30529 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999901742434167 0.999712876815577 0.99997973646933 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.605409800305391 0.0115361654751757 7.54087213596152 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 3 11501 23704 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.99987345509765 0.999630227076139 0.999973902638554 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.687012723531287 0.0130900577164196 8.55773267307823 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1327T>C rpoB_c.1327T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 3 16809 30529 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999901742434167 0.999712876815577 0.99997973646933 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.605409800305391 0.0115361654751757 7.54087213596152 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.132T>A rpoB_c.132T>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1332C>T rpoB_c.1332C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1341C>T rpoB_c.1341C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 59 16808 30473 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.998067601205292 0.997508044800699 0.998528653048731 0.0327868852459016 0.00399560316731648 0.113472167188181 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.0614578207310481 0.00727582217899025 0.23214237889904 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 59 11501 23648 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.997511283587126 0.996790895742339 0.998104950427385 0.0166666666666666 0.000421874452342009 0.089399050057487 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.0348503225216967 0.000872154239718867 0.201931422390146 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1344A>C rpoB_c.1344A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1344A>G rpoB_c.1344A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1344A>T rpoB_c.1344A>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1347G>A rpoB_c.1347G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-134T>G rpoB_c.-134T>G 1 upstream_gene_variant 759673 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.1350G>T rpoB_c.1350G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.341150751115529 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1353G>C rpoB_c.1353G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1354C>T rpoB_c.1354C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1356G>T rpoB_c.1356G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1359G>C rpoB_c.1359G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.908144446427509 0.0153974005043644 17.4461131425891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1359G>T rpoB_c.1359G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1365C>T rpoB_c.1365C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.908144446427509 0.0153974005043644 17.4461131425891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-136G>C rpoB_c.-136G>C 1 upstream_gene_variant 759671 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.1374A>C rpoB_c.1374A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-137C>T rpoB_c.-137C>T 1 upstream_gene_variant 759670 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.1383T>C rpoB_c.1383T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1389G>C rpoB_c.1389G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.138A>C rpoB_c.138A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 6 4 16804 30528 0.000356930398572278 0.000130998068917797 0.000776724091447791 0.999868989912223 0.999664596427238 0.999964303043777 0.6 0.262378076606945 0.878447741880172 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.72506546060461 0.646076910390347 13.1292748110224 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 4 11501 23703 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999831273463534 0.999568049920357 0.99995402584539 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.515237805408225 0.0104655802548345 5.20753049950472 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1390C>T rpoB_c.1390C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.908144446427509 0.0153974005043644 17.4461131425891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1392G>C rpoB_c.1392G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1392G>T rpoB_c.1392G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-140C>T rpoB_c.-140C>T 1 upstream_gene_variant 759667 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.1410C>T rpoB_c.1410C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 3 1 16807 30531 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999967247478055 0.999817528289014 0.999999170778282 0.75 0.194120449683243 0.99369053679029 NA NA NA NA NA NA NA NA NA NA NA NA False False 5.44969358005592 0.437509494081317 285.652299683162 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1413G>C rpoB_c.1413G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1413G>T rpoB_c.1413G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1425C>T rpoB_c.1425C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.75142405620251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1426C>A rpoB_c.1426C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1428G>C rpoB_c.1428G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-142C>T rpoB_c.-142C>T 1 upstream_gene_variant 759665 0 0 0 0 10 0 16800 30532 0.000594883997620464 0.000285305684944214 0.00109373983334496 1 0.999879187193184 1 1 0.691502892181239 1 NA NA NA NA NA NA NA NA NA NA 2607 4649 False False Inf 4.07313735951873 Inf 0 0 0.000219552052902727 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 10 0 11492 23707 0.000869414014953921 0.000416994043678715 0.001598300185227 1 0.999844409142079 1 1 0.691502892181239 1 NA NA NA NA NA NA NA NA NA NA 2168 3890 False False 0 0 0 0 0 0 0 Inf 4.62268854495848 Inf 0 0 0.000320943914091465 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB c.-143G>A rpoB_c.-143G>A 1 upstream_gene_variant 759664 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB c.1440C>T rpoB_c.1440C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1443A>G rpoB_c.1443A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.908144446427509 0.0153974005043644 17.4461131425891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1449T>G rpoB_c.1449T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1452G>A rpoB_c.1452G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1455G>C rpoB_c.1455G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1455G>T rpoB_c.1455G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1458C>G rpoB_c.1458C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1461C>T rpoB_c.1461C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 26 1 16784 30531 0.0015466983938132 0.00101059577405045 0.00226545603351431 0.999967247478055 0.999817528289014 0.999999170778282 0.962962962962962 0.810294382586955 0.999062742908055 NA NA NA NA NA NA NA NA NA NA NA NA False False 47.2954003813155 7.76798007272312 1920.59775630989 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 26 1 11476 23706 0.00226047643888019 0.00147713322194328 0.00331037981655982 0.999957818365883 0.999765001636458 0.999998932054057 0.962962962962962 0.810294382586955 0.999062742908055 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 53.7082607180202 8.81889187039071 2177.68412892723 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1467T>C rpoB_c.1467T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1468C>T rpoB_c.1468C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1470G>A rpoB_c.1470G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.147C>T rpoB_c.147C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1482G>A rpoB_c.1482G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 16 16809 30516 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999475959648893 0.999149130429312 0.999700436936355 0.0588235294117647 0.00148817439126663 0.28688939666722 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.113466000356951 0.00270968431653528 0.730490267498182 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 12 11501 23695 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999493820390602 0.999115973206486 0.999738423129043 0.0769230769230769 0.00194562849734675 0.360297435267877 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.171687969162101 0.00401993268933778 1.16069064496843 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1482G>C rpoB_c.1482G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1494G>A rpoB_c.1494G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1494G>C rpoB_c.1494G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1497G>C rpoB_c.1497G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1506G>A rpoB_c.1506G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.150C>A rpoB_c.150C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 18 16810 30514 0 0 0.000219421459229958 0.999410454605004 0.999068423526975 0.999650561796013 0 0 0.185301968137852 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.412919113913167 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 18 11502 23689 0 0 0.000320664925697395 0.999240730585902 0.998800291409329 0.999549948712402 0 0 0.185301968137852 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.468558999031164 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.150C>T rpoB_c.150C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.341150751115529 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-150G>A rpoB_c.-150G>A 1 upstream_gene_variant 759657 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.-151_-150insGT rpoB_c.-151_-150insGT 1 upstream_gene_variant 759656 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.1512G>C rpoB_c.1512G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1512G>T rpoB_c.1512G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1515C>T rpoB_c.1515C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1521A>G rpoB_c.1521A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1524G>A rpoB_c.1524G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1527G>T rpoB_c.1527G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-152C>T rpoB_c.-152C>T 1 upstream_gene_variant 759655 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2664 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.1533C>G rpoB_c.1533C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1533C>T rpoB_c.1533C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-153C>G rpoB_c.-153C>G 1 upstream_gene_variant 759654 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.1551G>A rpoB_c.1551G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1554T>C rpoB_c.1554T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1560C>T rpoB_c.1560C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1572C>T rpoB_c.1572C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1575G>A rpoB_c.1575G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1578C>T rpoB_c.1578C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1587G>A rpoB_c.1587G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-159_-158insT rpoB_c.-159_-158insT 1 upstream_gene_variant 759648 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.1596C>G rpoB_c.1596C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-159C>T rpoB_c.-159C>T 1 upstream_gene_variant 759648 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2677 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2227 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.1605G>C rpoB_c.1605G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1608A>G rpoB_c.1608A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 4 16809 30528 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999868989912223 0.999664596427238 0.999964303043777 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.454042477244333 0.00922341562850508 4.58878013974823 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-160T>C rpoB_c.-160T>C 1 upstream_gene_variant 759647 1 4 0 4 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.75142405620251 0.304356294847217 327.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12235036001139 0.310791984491028 261 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.-160T>G rpoB_c.-160T>G 1 upstream_gene_variant 759647 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.-161_-160insA rpoB_c.-161_-160insA 1 upstream_gene_variant 759646 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2449 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2035 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB c.-161G>A rpoB_c.-161G>A 1 upstream_gene_variant 759646 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB c.1623G>A rpoB_c.1623G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1626C>T rpoB_c.1626C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-163T>C rpoB_c.-163T>C 1 upstream_gene_variant 759644 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2403 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1997 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB c.-165_-164insG rpoB_c.-165_-164insG 1 upstream_gene_variant 759642 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.1656C>T rpoB_c.1656C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1659G>A rpoB_c.1659G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 15 26 16795 30506 0.000892325996430696 0.000499511372123772 0.00147132963433071 0.999148434429451 0.998752506314373 0.99944365605196 0.365853658536585 0.221227862061065 0.530637451967166 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.0479080312364 0.515828840784518 2.0542245831389 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 6 20 11496 23687 0.000521648408972352 0.000191459062774625 0.00113506056981396 0.99915636731767 0.998697376967606 0.99948461349205 0.23076923076923 0.0897401108845751 0.436475096941386 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.618136743215031 0.203079872025806 1.59649168970432 NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-165C>T rpoB_c.-165C>T 1 upstream_gene_variant 759642 1 1 1 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0465715996825058 Inf 0.355075831185839 416 4649 False False Inf 0.0465715996825058 Inf 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0528490600080728 Inf 0.32667783805277 340.5 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB c.1660C>T rpoB_c.1660C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1668C>T rpoB_c.1668C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-167G>A rpoB_c.-167G>A 1 upstream_gene_variant 759640 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.1683G>A rpoB_c.1683G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 167 184 16643 30348 0.00993456276026174 0.00849084811371116 0.0115514105365105 0.993973535962269 0.993040322042496 0.994810782542674 0.475783475783475 0.422509966601046 0.529468873769639 NA NA NA NA NA NA NA NA NA NA NA NA False True 1.65499661693517 1.33290496660187 2.05368372594354 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 79 141 11423 23566 0.00686837071813597 0.00544141519236754 0.00855279089705807 0.994052389589572 0.992989448577732 0.994991298196118 0.359090909090909 0.29571433156111 0.426322064462859 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 1 1.15588246433256 0.865398621179343 1.53461225939168 NA NA NA NA NA NA 36 5) Not assoc w R Now listed Silent mutation no 0 +Rifampicin rpoB c.-168G>C rpoB_c.-168G>C 1 upstream_gene_variant 759639 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2506 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2082 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB c.-169_-168insA rpoB_c.-169_-168insA 1 upstream_gene_variant 759638 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance No change no 1 +Rifampicin rpoB c.1692C>T rpoB_c.1692C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1695G>A rpoB_c.1695G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1698C>G rpoB_c.1698C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-169T>C rpoB_c.-169T>C 1 upstream_gene_variant 759638 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.1713C>T rpoB_c.1713C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1716C>T rpoB_c.1716C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1725C>T rpoB_c.1725C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1731C>G rpoB_c.1731C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-173A>G rpoB_c.-173A>G 1 upstream_gene_variant 759634 1 5 0 5 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.9820231071276 0.168448731581911 252 4649 False False 0 0 1.9820231071276 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12235036001139 0.310791984491028 261 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.1749G>C rpoB_c.1749G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-174C>G rpoB_c.-174C>G 1 upstream_gene_variant 759633 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB c.174G>A rpoB_c.174G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1752C>G rpoB_c.1752C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1758G>C rpoB_c.1758G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1764T>C rpoB_c.1764T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1767C>G rpoB_c.1767C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-176G>A rpoB_c.-176G>A 1 upstream_gene_variant 759631 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 1 3) Uncertain significance No change no 1 +Rifampicin rpoB c.1770C>T rpoB_c.1770C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1773G>A rpoB_c.1773G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1773G>C rpoB_c.1773G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1788C>T rpoB_c.1788C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-179C>T rpoB_c.-179C>T 1 upstream_gene_variant 759628 1 1 0 1 27 1 16783 30531 0.00160618679357525 0.00105874575067693 0.00233606351154523 0.999967247478055 0.999817528289014 0.999999170778282 0.964285714285714 0.816522402455376 0.999096201244342 0 0 0.975 0 0 0.975 0 0 70.8721907292819 1 1627.5 4649 False False 49.1173806828338 8.0934767209478 1991.09780703556 0 0 0.000219774419269166 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 26 0 11476 23707 0.00226047643888019 0.00147713322194328 0.00331037981655982 1 0.999844409142079 1 1 0.867725395502245 1 NA NA NA NA NA NA NA NA NA NA 1968 3890 False False 0 0 0 0 0 0 0 Inf 13.550678341775 Inf 0 0 0.00032139130668021 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.1800C>A rpoB_c.1800C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1806G>C rpoB_c.1806G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1806G>T rpoB_c.1806G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1809A>C rpoB_c.1809A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1809A>G rpoB_c.1809A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-180A>C rpoB_c.-180A>C 1 upstream_gene_variant 759627 1 2 1 1 4 1 16806 30531 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999967247478055 0.999817528289014 0.999999170778282 0.8 0.28358206388191 0.994949236620532 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.81667261692252 0.023141771135672298 142.451120075049 1 1627.5 4649 False False 7.26669046769011 0.71899465830523 357.208630433948 5.94990182661986e-05 1.50638358512048e-06 0.000331462229036007 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 4 0 11498 23707 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 1 0.999844409142079 1 1 0.397635364383525 1 1 0.025 1 1 0.025 1 Inf 0.0528628480096367 Inf 0.326620462421178 313.5 3890 False False 0 0 0 0 0 0 0 Inf 1.3608069907404 Inf 8.69640838333768e-05 2.20173755219544e-06 0.00048443655634461 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.1812C>T rpoB_c.1812C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1818G>A rpoB_c.1818G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-181C>G rpoB_c.-181C>G 1 upstream_gene_variant 759626 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2692 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2241 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB c.-181C>T rpoB_c.-181C>T 1 upstream_gene_variant 759626 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.1821C>T rpoB_c.1821C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-182C>T rpoB_c.-182C>T 1 upstream_gene_variant 759625 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2475 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2061 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB c.-183_-177delGCCACTT rpoB_c.-183_-177delGCCACTT 1 upstream_gene_variant 759623 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2373 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB c.1830G>C rpoB_c.1830G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1830G>T rpoB_c.1830G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1839C>G rpoB_c.1839C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1839C>T rpoB_c.1839C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.341150751115529 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.183G>A rpoB_c.183G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-183G>T rpoB_c.-183G>T 1 upstream_gene_variant 759624 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB c.1848G>A rpoB_c.1848G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1851C>G rpoB_c.1851C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1851C>T rpoB_c.1851C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1857G>A rpoB_c.1857G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-185C>A rpoB_c.-185C>A 1 upstream_gene_variant 759622 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.186G>C rpoB_c.186G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1887G>A rpoB_c.1887G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-188C>T rpoB_c.-188C>T 1 upstream_gene_variant 759619 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.1893C>T rpoB_c.1893C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1896C>G rpoB_c.1896C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1899C>A rpoB_c.1899C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-190C>T rpoB_c.-190C>T 1 upstream_gene_variant 759617 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2709 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB c.1914C>T rpoB_c.1914C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1923C>T rpoB_c.1923C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1926C>G rpoB_c.1926C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 3 16809 30529 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999901742434167 0.999712876815577 0.99997973646933 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.605409800305391 0.0115361654751757 7.54087213596152 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 3 11501 23704 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.99987345509765 0.999630227076139 0.999973902638554 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.687012723531287 0.0130900577164196 8.55773267307823 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1926C>T rpoB_c.1926C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 4 1 16806 30531 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999967247478055 0.999817528289014 0.999999170778282 0.8 0.28358206388191 0.994949236620532 NA NA NA NA NA NA NA NA NA NA NA NA False False 7.26669046769011 0.71899465830523 357.208630433948 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 4 1 11498 23706 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 0.999957818365883 0.999765001636458 0.999998932054057 0.8 0.28358206388191 0.994949236620532 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 8.24699947817011 0.815939832795188 405.284913246419 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1947C>T rpoB_c.1947C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-195C>A rpoB_c.-195C>A 1 upstream_gene_variant 759612 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1998 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.1980C>T rpoB_c.1980C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 8 16810 30524 0 0 0.000219421459229958 0.999737979824446 0.999483781433772 0.999886871715824 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.06393155676265 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 8 11502 23699 0 0 0.000320664925697395 0.999662546927068 0.999335191784523 0.999854300817065 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.20731769892417 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.1989C>A rpoB_c.1989C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-198C>A rpoB_c.-198C>A 1 upstream_gene_variant 759609 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.-199C>A rpoB_c.-199C>A 1 upstream_gene_variant 759608 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.-199C>G rpoB_c.-199C>G 1 upstream_gene_variant 759608 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.-199C>T rpoB_c.-199C>T 1 upstream_gene_variant 759608 1 61 3 58 23 64 16787 30468 0.00136823319452706 0.000867533996903047 0.00205231857920666 0.997903838595572 0.997324025972256 0.998385337547503 0.264367816091954 0.175543499859446 0.369823899081308 0.0491803278688524 0.0102593151683207 0.137069221915894 0.044776119402985 0.00933084341275691 0.125327035993941 0.0938780624580186 0.0188244468770378 0.288371996010012 2.19634270470511e-08 26 4649 True False 0.652256954786441 0.386294570217775 1.06563424377459 0.000178677784395473 3.68491705815158e-05 0.000522082634157649 0.997903838595572 0.997324025972256 0.998385337547503 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 44 3 41 14 45 11488 23662 0.00121717962093548 0.000665598145642159 0.00204137811638842 0.998101826464757 0.99746090963091 0.998615132614595 0.23728813559322 0.136225743584756 0.365949890056237 0.0681818181818181 0.0142876684269753 0.186562010072022 0.0625 0.0130792444095526 0.17195993079057 0.15071081595217 0.0298260136978918 0.472560210760781 7.30461727794957e-05 38 3890 True False 0 0 0 0 0 0 0 0.64080006190034 0.324699161814052 1.18939526031551 0.000261073883909146 5.38429476922868e-05 0.000762777233177637 0.998101826464757 0.99746090963091 0.998615132614595 5 3) Uncertain significance No change no 1 +Rifampicin rpoB c.-19A>C rpoB_c.-19A>C 1 upstream_gene_variant 759788 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2592 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2155 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB c.2004G>A rpoB_c.2004G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2010C>T rpoB_c.2010C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2025C>G rpoB_c.2025C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2031C>T rpoB_c.2031C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2037C>T rpoB_c.2037C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-203A>G rpoB_c.-203A>G 1 upstream_gene_variant 759604 1 8 0 8 4 8 16806 30524 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999737979824446 0.999483781433772 0.999886871715824 0.333333333333333 0.0992460911495833 0.651124493581186 0 0 0.369416647552819 0 0 0.369416647552819 0 0 1.06418480121815 0.0571702121065233 171 4649 False False 0.908128049506128 0.200090516675031 3.39037213523386 0 0 0.000219473678051534 0.999737979824446 0.999483781433772 0.999886871715824 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 1 6 11501 23701 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.9997469101953 0.999449212060655 0.99990711502044 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.75053841604795 0.18683809940591 207.5 3890 False False 0 0 0 0 0 0 0 0.343462887285163 0.00747035147172492 2.83150389371471 0 0 0.000320692802708327 0.9997469101953 0.999449212060655 0.99990711502044 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.2043C>T rpoB_c.2043C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2049C>T rpoB_c.2049C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2055C>T rpoB_c.2055C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2058G>A rpoB_c.2058G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2058G>C rpoB_c.2058G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-205C>T rpoB_c.-205C>T 1 upstream_gene_variant 759602 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB c.207C>T rpoB_c.207C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-209C>G rpoB_c.-209C>G 1 upstream_gene_variant 759598 1 1 1 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0465743703410529 Inf 0.355062208233877 391.5 4649 False False Inf 0.341150751115529 Inf 5.94919388422868e-05 1.50620434989522e-06 0.000331422795737767 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.052853655209362 Inf 0.326658713928652 320 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 8.69489609599165e-05 2.20135467503192e-06 0.000484352330576856 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.-209C>T rpoB_c.-209C>T 1 upstream_gene_variant 759598 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.-211C>T rpoB_c.-211C>T 1 upstream_gene_variant 759596 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2324 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB c.-212G>A rpoB_c.-212G>A 1 upstream_gene_variant 759595 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2314 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB c.2133G>A rpoB_c.2133G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2136C>T rpoB_c.2136C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 5 16808 30527 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999836237390279 0.999617874429585 0.999946824656822 0.285714285714285 0.0366925661760855 0.709579136262657 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.726487386958591 0.069161301215026 4.43811993507661 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 4 11501 23703 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999831273463534 0.999568049920357 0.99995402584539 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.515237805408225 0.0104655802548345 5.20753049950472 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2139G>T rpoB_c.2139G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.213G>A rpoB_c.213G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-213T>C rpoB_c.-213T>C 1 upstream_gene_variant 759594 2 1 0 1 4 1 16806 30531 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999967247478055 0.999817528289014 0.999999170778282 0.8 0.28358206388191 0.994949236620532 0 0 0.975 0 0 0.975 0 0 70.7753052263996 1 1627.5 4649 False False 7.26669046769011 0.71899465830523 357.208630433948 0 0 0.000219473678051534 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 0 1 4 1 11498 23706 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 0.999957818365883 0.999765001636458 0.999998932054057 0.8 0.28358206388191 0.994949236620532 0 0 0.975 0 0 0.975 0 0 80.3119851470932 1 1214.5 3890 False False 0 0 0 0 0 0 0 8.24699947817011 0.815939832795188 405.284913246419 0 0 0.000320776462830572 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.2140C>T rpoB_c.2140C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.908144446427509 0.0153974005043644 17.4461131425891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2142G>A rpoB_c.2142G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.341150751115529 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2142G>C rpoB_c.2142G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2148C>G rpoB_c.2148C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-214T>C rpoB_c.-214T>C 1 upstream_gene_variant 759593 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 80.2910622977969 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance No change no 1 +Rifampicin rpoB c.-215G>A rpoB_c.-215G>A 1 upstream_gene_variant 759592 1 1 0 1 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 70.7603724184383 1 1627.5 4649 False False 0.908144446427509 0.0153974005043644 17.4461131425891 0 0 0.000219434511605659 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 80.2910622977969 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance No change no 1 +Rifampicin rpoB c.-215G>T rpoB_c.-215G>T 1 upstream_gene_variant 759592 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.2163G>A rpoB_c.2163G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 2 16808 30530 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999934494956111 0.999763393503742 0.99999206693684 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.8163969538315 0.131636449523742 25.0652602654423 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2166C>G rpoB_c.2166C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2166C>T rpoB_c.2166C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2169C>T rpoB_c.2169C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-216C>G rpoB_c.-216C>G 1 upstream_gene_variant 759591 1 2 0 2 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 9.67028206568003 0.541992006917746 476.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 1 3) Uncertain significance No change no 1 +Rifampicin rpoB c.-216C>T rpoB_c.-216C>T 1 upstream_gene_variant 759591 1 2 1 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.81634838479386 0.0231376410853604 142.42572627634 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 2.06121206851578 0.0262561678399451 161.601678830082 0.54664351365823 365.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.2175C>T rpoB_c.2175C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.6329128986197 0.189104318453829 214.057761575796 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-217A>C rpoB_c.-217A>C 1 upstream_gene_variant 759590 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB c.-217A>G rpoB_c.-217A>G 1 upstream_gene_variant 759590 1 32 0 32 1 32 16809 30500 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.998951919297786 0.998520742016693 0.999283006561325 0.0303030303030303 0.000766912075048109 0.157593972272496 0 0 0.108881160679352 0 0 0.108881160679352 0 0 0.221748753521484 9.47125085427898e-07 33 4649 True False 0.0567032542090546 0.00139680741211992 0.339524529318663 0 0 0.000219434511605659 0.998951919297786 0.998520742016693 0.999283006561325 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 29 0 29 1 29 11501 23678 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.998776732610621 0.998243652703649 0.999180610346857 0.0333333333333333 0.000843570926630479 0.172169455633412 0 0 0.119444869069502 0 0 0.119444869069502 0 0 0.279340949553167 1.26970699071572e-05 30 3890 True False 0 0 0 0 0 0 0 0.0709923275037553 0.00174220312431261 0.428280628789702 0 0 0.000320692802708327 0.998776732610621 0.998243652703649 0.999180610346857 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.2184G>C rpoB_c.2184G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2187C>T rpoB_c.2187C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-218G>A rpoB_c.-218G>A 1 upstream_gene_variant 759589 1 14 0 14 0 14 16810 30518 0 0 0.000219421459229958 0.999541464692781 0.999230775228684 0.999749292529582 0 0 0.231635761650116 0 0 0.231635761650116 0 0 0.231635761650116 0 0 0.547412779991011 0.00341905087794529 81 4649 False False 0 0 0.547412779991011 0 0 0.000219421459229958 0.999541464692781 0.999230775228684 0.999749292529582 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 0 10 11502 23697 0 0 0.000320664925697395 0.999578183658835 0.999224402000993 0.999797704727851 0 0 0.30849710781876 0 0 0.30849710781876 0 0 0.30849710781876 0 0 0.919347572200535 0.0366166693953064 107 3890 False False 0 0 0 0 0 0 0 0 0 0.919347572200535 0 0 0.000320664925697395 0.999578183658835 0.999224402000993 0.999797704727851 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.2191C>T rpoB_c.2191C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2196C>T rpoB_c.2196C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-219G>A rpoB_c.-219G>A 1 upstream_gene_variant 759588 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 1 3) Uncertain significance No change no 1 +Rifampicin rpoB c.-21G>C rpoB_c.-21G>C 1 upstream_gene_variant 759786 1 7 1 6 12 8 16798 30524 0.000713860797144556 0.000368914962606047 0.00124663876852724 0.999737979824446 0.999483781433772 0.999886871715824 0.6 0.360542587307489 0.808809939274692 0.142857142857142 0.00361029686190058 0.578723197043195 0.111111111111111 0.00280913674659921 0.482496514917337 0.302853514307258 0.0065878412865044 2.49661026404446 0.433506005320234 442 4649 False False 2.72568162876532 1.02430321026523 7.68890030080649 5.95273528186201e-05 1.50710095279712e-06 0.000331620056110586 0.999737979824446 0.999483781433772 0.999886871715824 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 7 6 11495 23701 0.000608589810467744 0.000244718560881119 0.00125352303681455 0.9997469101953 0.999449212060655 0.99990711502044 0.538461538461538 0.251345482270303 0.807767558198712 0 0 0.521823750104981 0 0 0.4592581264399 0 0 2.25040392089429 0.180494601380876 199 3890 False False 0 0 0 0 0 0 0 2.40549514281571 0.692028881085274 8.66552232847307 0 0 0.000320860166613556 0.9997469101953 0.999449212060655 0.99990711502044 2 3) Uncertain significance No change no 1 +Rifampicin rpoB c.2200_2202delCGCinsAGG rpoB_c.2200_2202delCGCinsAGG 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2202C>T rpoB_c.2202C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2203C>T rpoB_c.2203C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2205G>A rpoB_c.2205G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.750576632084797 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2205G>C rpoB_c.2205G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 7 16810 30525 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.26007067420399 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 7 11502 23700 0 0 0.000320664925697395 0.999704728561184 0.999391723222185 0.999881277590374 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.42986888806462 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2208C>G rpoB_c.2208C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-220T>C rpoB_c.-220T>C 1 upstream_gene_variant 759587 1 5 0 5 4 11 16806 30521 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999639722258614 0.999355455254591 0.999820137367966 0.266666666666666 0.0778715462910436 0.551003241036971 0 0 0.521823750104981 0 0 0.284914152918154 0 0 1.98210525203412 0.168451456367724 266 4649 False False 0.660391851395064 0.153338300393312 2.22912258327868 0 0 0.000219473678051534 0.999639722258614 0.999355455254591 0.999820137367966 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 4 9 11498 23698 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 0.999620365292951 0.999279457952852 0.99982639261309 0.307692307692307 0.0909203945720966 0.614261661750705 0 0 0.602364635616474 0 0 0.336267116879942 0 0 3.12277793410448 0.310802783887337 288 3890 False False 0 0 0 0 0 0 0 0.916024042828704 0.206092090298021 3.28293889927942 0 0 0.000320776462830572 0.999620365292951 0.999279457952852 0.99982639261309 2 3) Uncertain significance No change no 1 +Rifampicin rpoB c.2211A>G rpoB_c.2211A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2223C>G rpoB_c.2223C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2223C>T rpoB_c.2223C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2232C>T rpoB_c.2232C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2235C>T rpoB_c.2235C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2238C>T rpoB_c.2238C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-223T>C rpoB_c.-223T>C 1 upstream_gene_variant 759584 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.2241G>A rpoB_c.2241G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2247T>C rpoB_c.2247T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 3 16809 30529 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999901742434167 0.999712876815577 0.99997973646933 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.605409800305391 0.0115361654751757 7.54087213596152 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2250G>A rpoB_c.2250G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2256T>C rpoB_c.2256T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2259T>C rpoB_c.2259T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2259T>G rpoB_c.2259T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.225C>T rpoB_c.225C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.341150751115529 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2268C>A rpoB_c.2268C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.341150751115529 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2277T>C rpoB_c.2277T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-227C>A rpoB_c.-227C>A 1 upstream_gene_variant 759580 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.2280G>C rpoB_c.2280G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2295C>G rpoB_c.2295C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2295C>T rpoB_c.2295C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2301C>T rpoB_c.2301C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.231G>A rpoB_c.231G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2328C>G rpoB_c.2328C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2331C>T rpoB_c.2331C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2332C>T rpoB_c.2332C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-233C>T rpoB_c.-233C>T 1 upstream_gene_variant 759574 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.2343G>C rpoB_c.2343G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2343G>T rpoB_c.2343G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2346C>T rpoB_c.2346C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2352G>C rpoB_c.2352G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2355C>T rpoB_c.2355C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-235G>A rpoB_c.-235G>A 1 upstream_gene_variant 759572 2 7 1 6 4 6 16806 30526 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999803484868334 0.999572318737888 0.999927879105266 0.4 0.121552258119827 0.737621923393055 0.142857142857142 0.00361029686190058 0.578723197043195 0.142857142857142 0.00361029686190058 0.578723197043195 0.302729184021579 0.00658513896883202 2.49558524786217 0.433507526561974 443 4649 False False 1.21091673608631 0.25129786177201 5.10706056868951 5.94990182661986e-05 1.50638358512048e-06 0.000331462229036007 0.999803484868334 0.999572318737888 0.999927879105266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 6 1 5 4 5 11498 23702 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 0.999789091829417 0.999507879904061 0.999931515258336 0.444444444444444 0.136995662265166 0.787991493221131 0.166666666666666 0.00421074451448947 0.641234578997674 0.166666666666666 0.00421074451448947 0.641234578997674 0.412280396590711 0.00872009274920813 3.68519767587278 0.670955183122266 493 3890 False False 0 0 0 0 0 0 0 1.64912158636284 0.327175514256965 7.66332787722062 8.69640838333768e-05 2.20173755219544e-06 0.00048443655634461 0.999789091829417 0.999507879904061 0.999931515258336 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.2361T>C rpoB_c.2361T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 3 16808 30529 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999901742434167 0.999712876815577 0.99997973646933 0.4 0.0527449505263169 0.853367200365326 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.21089163890211 0.101157890363798 10.5697741171107 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2361T>G rpoB_c.2361T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.341150751115529 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2364C>A rpoB_c.2364C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2364C>G rpoB_c.2364C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2364C>T rpoB_c.2364C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2370T>C rpoB_c.2370T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2379G>A rpoB_c.2379G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2379G>C rpoB_c.2379G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2388G>C rpoB_c.2388G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.238C>T rpoB_c.238C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2391C>A rpoB_c.2391C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2394C>T rpoB_c.2394C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2403C>G rpoB_c.2403C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2406G>A rpoB_c.2406G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 20 1 16790 30531 0.00118976799524092 0.000726887900057249 0.00183690503094944 0.999967247478055 0.999817528289014 0.999999170778282 0.952380952380952 0.761840090063179 0.998795116551636 NA NA NA NA NA NA NA NA NA NA NA NA False False 36.3680762358546 5.81547441836226 1496.48529714675 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 9 1 11493 23706 0.000782472613458529 0.000357856744032263 0.00148485474620048 0.999957818365883 0.999765001636458 0.999998932054057 0.9 0.554983882971804 0.997471421455538 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 18.5638214565387 2.57162110235215 810.478378810226 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2406G>C rpoB_c.2406G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2409G>A rpoB_c.2409G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2427G>A rpoB_c.2427G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2427G>C rpoB_c.2427G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2430G>C rpoB_c.2430G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2439G>C rpoB_c.2439G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2443C>T rpoB_c.2443C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.341150751115529 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2448T>C rpoB_c.2448T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2463G>A rpoB_c.2463G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2469C>T rpoB_c.2469C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2478G>C rpoB_c.2478G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2487T>C rpoB_c.2487T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2490G>C rpoB_c.2490G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2499G>C rpoB_c.2499G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-250delT rpoB_c.-250delT 1 upstream_gene_variant 759556 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.2511A>G rpoB_c.2511A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2517C>A rpoB_c.2517C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2523G>A rpoB_c.2523G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2523G>C rpoB_c.2523G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2523G>T rpoB_c.2523G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-252T>C rpoB_c.-252T>C 1 upstream_gene_variant 759555 1 3 0 3 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 4.39540875925228 0.556930310247326 910.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.-253G>C rpoB_c.-253G>C 1 upstream_gene_variant 759554 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB c.2553C>T rpoB_c.2553C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.255C>T rpoB_c.255C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-256C>T rpoB_c.-256C>T 1 upstream_gene_variant 759551 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.-257C>T rpoB_c.-257C>T 1 upstream_gene_variant 759550 1 9 0 9 0 9 16810 30523 0 0 0.000219421459229958 0.999705227302502 0.999440503684993 0.999865202576615 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.920078094923294 0.0314975203720328 131 4649 False False 0 0 0.920078094923294 0 0 0.000219421459229958 0.999705227302502 0.999440503684993 0.999865202576615 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12235036001139 0.310791984491028 261 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 1 3) Uncertain significance No change no 1 +Rifampicin rpoB c.2586G>A rpoB_c.2586G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-258G>A rpoB_c.-258G>A 1 upstream_gene_variant 759549 1 5 0 5 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.9820231071276 0.168448731581911 252 4649 False False 0 0 1.9820231071276 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 2.24912710990902 0.180424970179968 177 3890 False False 0 0 0 0 0 0 0 0 0 2.24912710990902 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.2595G>A rpoB_c.2595G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2598T>C rpoB_c.2598T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.908144446427509 0.0153974005043644 17.4461131425891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.259C>T rpoB_c.259C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2604T>G rpoB_c.2604T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2607G>A rpoB_c.2607G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2610A>G rpoB_c.2610A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2613C>T rpoB_c.2613C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2619C>T rpoB_c.2619C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-261A>G rpoB_c.-261A>G 1 upstream_gene_variant 759546 1 525 11 514 70 579 16740 29953 0.00416418798334324 0.00324758416539656 0.00525831335367222 0.981036289794314 0.97944338850918 0.982536707237268 0.107858243451463 0.0850504991137657 0.13430233982757 0.0209523809523809 0.0105046451730197 0.037179813090217 0.0186440677966101 0.00934288035182359 0.033114083660252 0.038292563305115 0.0189915608096092 0.0691312572889991 1.03561221064728e-81 NA NA False True 0.216323822847863 0.166212482999271 0.277824263188162 0.000656677213300698 0.000327855028571455 0.00117467243889146 0.981036289794314 0.97944338850918 0.982536707237268 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 397 5 392 44 435 11458 23272 0.00382542166579725 0.00278089167957464 0.00513208463094438 0.98165098915932 0.979861209717595 0.983321256310419 0.0918580375782881 0.0675380215136311 0.121352007302928 0.0125944584382871 0.00410169059178302 0.0291451047185397 0.0113636363636363 0.00369975346501849 0.0263184848064955 0.0259065050352485 0.00836216586902285 0.0610027451336014 1.01757253840455e-59 NA NA False True 0 1 1 0 0 1 0 0.20544156268872 0.146994898542472 0.280784402626786 0.00043618598970601 0.000141643087452603 0.00101761655017738 0.98165098915932 0.979861209717595 0.983321256310419 102 Not assoc w R 5) Not assoc w R No change yes 1 +Rifampicin rpoB c.2625C>T rpoB_c.2625C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2628T>G rpoB_c.2628T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1009 4350 15801 26182 0.0600237953599048 0.0564796721935154 0.0637210715227601 0.857526529542774 0.853555466532802 0.861429436798854 0.188281395782795 0.177893223796066 0.199010148155032 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.384344043407699 0.357572712606924 0.412855197399489 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 676 3578 10826 20129 0.058772387410885 0.054542735744756 0.0632270311718611 0.849074113131142 0.844453415994979 0.853609058684498 0.15890926187118 0.148042590970587 0.170246462195015 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 1 0.351285753186979 0.322042161123474 0.382776925852164 NA NA NA NA NA NA 669 5) Not assoc w R Now listed Silent mutation no 0 +Rifampicin rpoB c.2631C>T rpoB_c.2631C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.908144446427509 0.0153974005043644 17.4461131425891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2634G>A rpoB_c.2634G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2635C>T rpoB_c.2635C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.75142405620251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-264_-263insTT rpoB_c.-264_-263insTT 1 upstream_gene_variant 759543 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.2643C>A rpoB_c.2643C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2644C>A rpoB_c.2644C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2646G>C rpoB_c.2646G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2655C>T rpoB_c.2655C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2664G>C rpoB_c.2664G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2670C>T rpoB_c.2670C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2677C>T rpoB_c.2677C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2679G>C rpoB_c.2679G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.6329128986197 0.189104318453829 214.057761575796 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2679G>T rpoB_c.2679G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2682G>C rpoB_c.2682G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2685T>C rpoB_c.2685T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-26C>T rpoB_c.-26C>T 1 upstream_gene_variant 759781 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB c.2700C>T rpoB_c.2700C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 8 11 16802 30521 0.000475907198096371 0.00020548462525215 0.000937510381255989 0.999639722258614 0.999355455254591 0.999820137367966 0.421052631578947 0.202521438977162 0.665002155988264 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.32109813766759 0.461207891392187 3.60668707596101 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 7 7 11495 23700 0.000608589810467744 0.000244718560881119 0.00125352303681455 0.999704728561184 0.999391723222185 0.999881277590374 0.5 0.230360541448062 0.769639458551937 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06176598521096 0.616950017145769 6.890951816192 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2709C>T rpoB_c.2709C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2718G>A rpoB_c.2718G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2721G>A rpoB_c.2721G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2742C>T rpoB_c.2742C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2754A>G rpoB_c.2754A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2766C>A rpoB_c.2766C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 3 7 16807 30525 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.99977073234639 0.999527678427408 0.999907817703152 0.3 0.0667395111777345 0.652452850059997 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.778374656818162 0.129888199762363 3.41016225344332 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 2 5 11500 23702 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999789091829417 0.999507879904061 0.999931515258336 0.285714285714285 0.0366925661760855 0.709579136262657 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.824417391304347 0.0784856369585262 5.0365353499031 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.276C>T rpoB_c.276C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2784C>T rpoB_c.2784C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2787C>T rpoB_c.2787C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2788C>T rpoB_c.2788C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2793T>C rpoB_c.2793T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.279C>T rpoB_c.279C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2829C>T rpoB_c.2829C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2850C>T rpoB_c.2850C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2857C>T rpoB_c.2857C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.285G>C rpoB_c.285G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2874C>T rpoB_c.2874C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2883G>A rpoB_c.2883G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2889C>T rpoB_c.2889C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2907G>A rpoB_c.2907G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2916C>T rpoB_c.2916C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.341150751115529 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2919C>A rpoB_c.2919C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2919C>T rpoB_c.2919C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2925G>A rpoB_c.2925G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2934G>A rpoB_c.2934G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2940G>A rpoB_c.2940G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2943C>T rpoB_c.2943C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2944C>T rpoB_c.2944C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2947T>C rpoB_c.2947T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.295T>C rpoB_c.295T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2976T>C rpoB_c.2976T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.297G>A rpoB_c.297G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.2982G>C rpoB_c.2982G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3003G>A rpoB_c.3003G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3006C>G rpoB_c.3006C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.300G>A rpoB_c.300G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 58 258 16752 30274 0.00345032718619869 0.00262098906992089 0.00445809435930149 0.991549849338399 0.990458575639933 0.992545979313899 0.183544303797468 0.142423633963088 0.230712672421896 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.406266890266023 0.299933070260497 0.542365687939306 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 45 235 11457 23472 0.00391236306729264 0.00285509282253167 0.00523158571947652 0.990087315982621 0.98874322461085 0.991309118385685 0.160714285714285 0.119706099788228 0.209074645043769 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 0 0.392304992395246 0.278380482698281 0.542045373304864 NA NA NA NA NA NA 14 5) Not assoc w R Now listed Silent mutation no 0 +Rifampicin rpoB c.3012C>G rpoB_c.3012C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3021G>C rpoB_c.3021G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3024C>G rpoB_c.3024C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3025_3026delAGinsTC rpoB_c.3025_3026delAGinsTC 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3027C>T rpoB_c.3027C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.341150751115529 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3030C>T rpoB_c.3030C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3036G>A rpoB_c.3036G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.304_306delTCTinsAGC rpoB_c.304_306delTCTinsAGC 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3051C>G rpoB_c.3051C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.6329128986197 0.189104318453829 214.057761575796 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3054G>C rpoB_c.3054G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3057T>C rpoB_c.3057T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3060C>T rpoB_c.3060C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.306T>A rpoB_c.306T>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3072C>T rpoB_c.3072C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3079C>T rpoB_c.3079C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3081G>C rpoB_c.3081G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3088C>T rpoB_c.3088C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3093G>C rpoB_c.3093G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.309C>T rpoB_c.309C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 977 3152 15833 27380 0.0581201665675193 0.0546301941936453 0.0617639797892783 0.896764050831914 0.893296927792377 0.900155476490107 0.236619036086219 0.223724411099675 0.249887329409853 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.536017028624594 0.497083201925578 0.5776463330104 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 681 2516 10821 21191 0.059207094418362 0.0549624626438199 0.0636764864766927 0.893871008562871 0.88988081362992 0.897764352051162 0.213012198936502 0.198930740516597 0.22762060419361 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 1 0.53005450451185 0.484774220136078 0.578989744897479 NA NA NA NA NA NA 190 5) Not assoc w R Now listed Silent mutation no 0 +Rifampicin rpoB c.3108C>T rpoB_c.3108C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 14 16810 30518 0 0 0.000219421459229958 0.999541464692781 0.999230775228684 0.999749292529582 0 0 0.231635761650116 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.547412779991011 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 13 11502 23694 0 0 0.000320664925697395 0.999451638756485 0.999062468123692 0.999707989454911 0 0 0.24705263800047 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.676068752178923 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3111C>G rpoB_c.3111C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3114C>T rpoB_c.3114C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3117C>G rpoB_c.3117C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3120C>A rpoB_c.3120C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3120C>T rpoB_c.3120C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 15 0 16795 30532 0.000892325996430696 0.000499511372123772 0.00147132963433071 1 0.999879187193184 1 1 0.781980639089466 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 6.51893136980533 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 15 0 11487 23707 0.00130412102243088 0.000730084557867185 0.00215003854003137 1 0.999844409142079 1 1 0.781980639089466 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 7.40065484717093 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3123G>A rpoB_c.3123G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 6 11 16804 30521 0.000356930398572278 0.000130998068917797 0.000776724091447791 0.999639722258614 0.999355455254591 0.999820137367966 0.352941176470588 0.14209748311022 0.616716336556597 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.990705676137716 0.30078364952977 2.92317510201488 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 6 10 11496 23697 0.000521648408972352 0.000191459062774625 0.00113506056981396 0.999578183658835 0.999224402000993 0.999797704727851 0.375 0.151983675081122 0.645653905697921 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.23679540709812 0.369335124594985 3.75660448725682 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3123G>C rpoB_c.3123G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3123G>T rpoB_c.3123G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.312T>C rpoB_c.312T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.312T>G rpoB_c.312T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 9 16809 30523 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999705227302502 0.999440503684993 0.999865202576615 0.1 0.00252857854446178 0.445016117028195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.201763605475902 0.00460699063398853 1.45637661246692 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 7 11501 23700 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999704728561184 0.999391723222185 0.999881277590374 0.125 0.0031597235312519 0.526509670875206 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.294384339250003 0.00653526389697788 2.29204336611244 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3141C>T rpoB_c.3141C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3144G>A rpoB_c.3144G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3151C>T rpoB_c.3151C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3153G>C rpoB_c.3153G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3156C>T rpoB_c.3156C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.315T>C rpoB_c.315T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3162G>A rpoB_c.3162G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3165G>A rpoB_c.3165G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3171C>T rpoB_c.3171C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.9820231071276 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3183G>A rpoB_c.3183G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3183G>T rpoB_c.3183G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3189G>C rpoB_c.3189G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 7 7 16803 30525 0.000416418798334324 0.000167437820935922 0.000857792460925722 0.99977073234639 0.999527678427408 0.999907817703152 0.5 0.230360541448062 0.769639458551937 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81663988573469 0.543630212732014 6.07052530040462 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3189G>T rpoB_c.3189G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 2 16808 30530 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999934494956111 0.999763393503742 0.99999206693684 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.8163969538315 0.131636449523742 25.0652602654423 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 2 11500 23705 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999915636731767 0.999695284447545 0.999989783053538 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06130434782608 0.149383229063395 28.4413197127326 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.318C>T rpoB_c.318C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3198G>A rpoB_c.3198G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3201C>T rpoB_c.3201C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3207C>T rpoB_c.3207C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3222T>C rpoB_c.3222T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3225T>C rpoB_c.3225T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 9507 14836 7303 15696 0.565556216537775 0.558022438724697 0.57306730298194 0.514083584436001 0.508459897758313 0.519704590773941 0.39054348272604 0.384407630723925 0.396705476824123 NA NA NA NA NA NA NA NA NA NA NA NA False True 1.37725500295771 1.32582624272284 1.43065926479704 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 6369 11303 5133 12404 0.553729786124152 0.544588998990434 0.562843364775449 0.523220989581136 0.51683951868321 0.529596765963287 0.360400633770937 0.353317114673006 0.367530118134608 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 1 1.36165791416945 1.30176378199023 1.42429397470986 NA NA NA NA NA NA 3361 5) Not assoc w R Now listed Silent mutation no 0 +Rifampicin rpoB c.3225T>G rpoB_c.3225T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 4 16809 30528 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999868989912223 0.999664596427238 0.999964303043777 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.454042477244333 0.00922341562850508 4.58878013974823 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 4 11501 23703 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999831273463534 0.999568049920357 0.99995402584539 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.515237805408225 0.0104655802548345 5.20753049950472 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3228C>G rpoB_c.3228C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 3 4 16807 30528 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999868989912223 0.999664596427238 0.999964303043777 0.428571428571428 0.0989882784425078 0.815948432359917 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.36228952222288 0.19952864446048 8.05486976701789 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 3 2 11499 23705 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.999915636731767 0.999695284447545 0.999989783053538 0.6 0.146632799634673 0.947255049473683 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.09222541090529 0.354154889835857 37.0377673791385 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3234C>G rpoB_c.3234C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3234C>T rpoB_c.3234C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3247T>C rpoB_c.3247T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3252C>T rpoB_c.3252C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3261C>A rpoB_c.3261C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3261C>T rpoB_c.3261C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3264T>C rpoB_c.3264T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.908144446427509 0.0153974005043644 17.4461131425891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3276C>T rpoB_c.3276C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3279C>G rpoB_c.3279C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3279C>T rpoB_c.3279C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.327C>T rpoB_c.327C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3282C>G rpoB_c.3282C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3288G>C rpoB_c.3288G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3288G>T rpoB_c.3288G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3291C>T rpoB_c.3291C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 3 16809 30529 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999901742434167 0.999712876815577 0.99997973646933 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.605409800305391 0.0115361654751757 7.54087213596152 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3297G>T rpoB_c.3297G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3300C>T rpoB_c.3300C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3309T>C rpoB_c.3309T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3321G>C rpoB_c.3321G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3321G>T rpoB_c.3321G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3324G>A rpoB_c.3324G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3327G>A rpoB_c.3327G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3330C>T rpoB_c.3330C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3339G>A rpoB_c.3339G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.333A>G rpoB_c.333A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3351G>A rpoB_c.3351G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3351G>T rpoB_c.3351G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3354G>A rpoB_c.3354G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3360A>G rpoB_c.3360A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3366G>C rpoB_c.3366G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3369G>A rpoB_c.3369G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.336C>T rpoB_c.336C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 5 1 16805 30531 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 0.999967247478055 0.999817528289014 0.999999170778282 0.833333333333333 0.358765421002325 0.99578925548551 NA NA NA NA NA NA NA NA NA NA NA NA False False 9.08390360011901 1.01631102884943 428.726615606949 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 5 1 11497 23706 0.00043470700747696 0.000141162766530747 0.00101416710312943 0.999957818365883 0.999765001636458 0.999998932054057 0.833333333333333 0.358765421002325 0.99578925548551 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 10.3096459946072 1.15337945963023 486.419600220716 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3378C>T rpoB_c.3378C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 11 16810 30521 0 0 0.000219421459229958 0.999639722258614 0.999355455254591 0.999820137367966 0 0 0.284914152918154 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.723522114724776 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 10 11502 23697 0 0 0.000320664925697395 0.999578183658835 0.999224402000993 0.999797704727851 0 0 0.30849710781876 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.919347572200535 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3387C>G rpoB_c.3387C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3399G>A rpoB_c.3399G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 12 16808 30520 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999606969736669 0.999313555980458 0.999796899563454 0.142857142857142 0.0177945154831915 0.428129160909698 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.302633666508012 0.032889580275051 1.35967332152622 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 2 8 11500 23699 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999662546927068 0.999335191784523 0.999854300817065 0.2 0.0252107263268333 0.556095462307641 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.515195652173913 0.0532924302528778 2.58225829949872 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3408T>C rpoB_c.3408T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3421C>T rpoB_c.3421C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3432T>C rpoB_c.3432T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 1 16807 30531 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999967247478055 0.999817528289014 0.999999170778282 0.75 0.194120449683243 0.99369053679029 NA NA NA NA NA NA NA NA NA NA NA NA False False 5.44969358005592 0.437509494081317 285.652299683162 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 1 11499 23706 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.999957818365883 0.999765001636458 0.999998932054057 0.75 0.194120449683243 0.99369053679029 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 6.18471171406209 0.496496186771195 324.103527365594 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3438C>T rpoB_c.3438C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 4 3 16806 30529 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999901742434167 0.999712876815577 0.99997973646933 0.571428571428571 0.184051567640083 0.901011721557492 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.42207148240707 0.409695730236002 16.540132512068 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 2 3 11500 23704 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.99987345509765 0.999630227076139 0.999973902638554 0.4 0.0527449505263169 0.853367200365326 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.37414492753623 0.114734681491877 11.9942804069209 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3459G>T rpoB_c.3459G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3462C>G rpoB_c.3462C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3466C>T rpoB_c.3466C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3471A>C rpoB_c.3471A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3474C>T rpoB_c.3474C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 9 16808 30523 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999705227302502 0.999440503684993 0.999865202576615 0.181818181818181 0.0228311982999596 0.517755852360172 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.403551218996245 0.042426946391261 1.95003944120586 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 2 7 11500 23700 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999704728561184 0.999391723222185 0.999881277590374 0.222222222222222 0.0281449734778982 0.600093573716312 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.588819875776397 0.0596633171436625 3.09306705863206 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3477T>C rpoB_c.3477T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3483C>T rpoB_c.3483C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.3510T>C rpoB_c.3510T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.357G>A rpoB_c.357G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 2 16808 30530 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999934494956111 0.999763393503742 0.99999206693684 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.8163969538315 0.131636449523742 25.0652602654423 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 2 2 11500 23705 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999915636731767 0.999695284447545 0.999989783053538 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06130434782608 0.149383229063395 28.4413197127326 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.360C>T rpoB_c.360C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.366G>T rpoB_c.366G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.36T>C rpoB_c.36T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.372G>A rpoB_c.372G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.341150751115529 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.372G>C rpoB_c.372G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.375T>C rpoB_c.375T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.378A>G rpoB_c.378A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 4 16809 30528 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999868989912223 0.999664596427238 0.999964303043777 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.454042477244333 0.00922341562850508 4.58878013974823 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 4 11501 23703 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999831273463534 0.999568049920357 0.99995402584539 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.515237805408225 0.0104655802548345 5.20753049950472 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-37C>G rpoB_c.-37C>G 1 upstream_gene_variant 759770 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2773 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.381G>A rpoB_c.381G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.381G>T rpoB_c.381G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.390C>G rpoB_c.390C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.390C>T rpoB_c.390C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.396G>A rpoB_c.396G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-3A>G rpoB_c.-3A>G 1 upstream_gene_variant 759804 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.-40G>C rpoB_c.-40G>C 1 upstream_gene_variant 759767 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.414C>T rpoB_c.414C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-41A>G rpoB_c.-41A>G 1 upstream_gene_variant 759766 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB c.423C>T rpoB_c.423C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.429T>C rpoB_c.429T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-42A>G rpoB_c.-42A>G 1 upstream_gene_variant 759765 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2522 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2093 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.438G>C rpoB_c.438G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.447T>C rpoB_c.447T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-44C>T rpoB_c.-44C>T 1 upstream_gene_variant 759763 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.450C>T rpoB_c.450C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.453C>T rpoB_c.453C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.45G>A rpoB_c.45G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.45G>T rpoB_c.45G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.471G>A rpoB_c.471G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.474C>T rpoB_c.474C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.477G>C rpoB_c.477G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.492G>C rpoB_c.492G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.495C>G rpoB_c.495C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-49C>G rpoB_c.-49C>G 1 upstream_gene_variant 759758 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB c.507G>A rpoB_c.507G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.507G>T rpoB_c.507G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-50G>A rpoB_c.-50G>A 1 upstream_gene_variant 759757 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2435 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2025 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.519G>A rpoB_c.519G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.519G>C rpoB_c.519G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-51C>T rpoB_c.-51C>T 1 upstream_gene_variant 759756 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2523 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2094 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 1 3) Uncertain significance No change no 1 +Rifampicin rpoB c.531C>T rpoB_c.531C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.534G>A rpoB_c.534G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.534G>T rpoB_c.534G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-53A>G rpoB_c.-53A>G 1 upstream_gene_variant 759754 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.-54C>A rpoB_c.-54C>A 1 upstream_gene_variant 759753 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.54G>A rpoB_c.54G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.555T>C rpoB_c.555T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-56G>T rpoB_c.-56G>T 1 upstream_gene_variant 759751 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.588C>G rpoB_c.588C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.588C>T rpoB_c.588C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-58T>G rpoB_c.-58T>G 1 upstream_gene_variant 759749 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB c.-59_-58insT rpoB_c.-59_-58insT 1 upstream_gene_variant 759748 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.594G>C rpoB_c.594G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.597C>T rpoB_c.597C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-59delG rpoB_c.-59delG 1 upstream_gene_variant 759747 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.603C>T rpoB_c.603C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.606C>A rpoB_c.606C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.609C>T rpoB_c.609C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-60C>T rpoB_c.-60C>T 1 upstream_gene_variant 759747 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.612G>C rpoB_c.612G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.618C>G rpoB_c.618C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-61C>T rpoB_c.-61C>T 1 upstream_gene_variant 759746 1 3838 61 3777 964 4093 15846 26439 0.0573468173706127 0.0538791465146747 0.0609686089418753 0.865943927682431 0.862071007993874 0.869747077085575 0.190626853865928 0.179882916162754 0.201729091533528 0.0158936946326211 0.0121786570431542 0.0203698427632625 0.0146846413095811 0.0112507111215386 0.0188235425477187 0.0269468635617821 0.0205599656514968 0.0347183365699748 0 NA NA False True 0.392971145220462 0.364990522757233 0.42280834296112 0.00383478971521971 0.00293454179830557 0.0049232588191289 0.865943927682431 0.862071007993874 0.869747077085575 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 3150 39 3111 640 3347 10862 20360 0.0556424969570509 0.0515227049772911 0.059988954243535 0.858818070612055 0.854320487551104 0.863227493428094 0.160521695510408 0.149253644614262 0.172289599918517 0.0123809523809523 0.00881847762153747 0.0168866579864568 0.0115180153573538 0.00820290253611767 0.015712179371741 0.0234980904472289 0.0166421725070492 0.0322423101590417 0 NA NA False True 0 1 1 0 0 1 1 0.358420001103558 0.327802149424451 0.391457926574848 0.00357765342629116 0.00254526088595067 0.0048875575974005 0.858818070612055 0.854320487551104 0.863227493428094 644 Not assoc w R 5) Not assoc w R No change yes 1 +Rifampicin rpoB c.624T>C rpoB_c.624T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-62C>T rpoB_c.-62C>T 1 upstream_gene_variant 759745 2 2 0 2 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.67117271135833 0.542004252564565 721 4649 False False 0.908144446427509 0.0153974005043644 17.4461131425891 0 0 0.000219434511605659 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 2 0 2 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.9727417274169 1 1214.5 3890 False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 0 0 0.000320692802708327 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.642C>T rpoB_c.642C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.645C>G rpoB_c.645C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.648C>T rpoB_c.648C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.651C>T rpoB_c.651C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.654G>C rpoB_c.654G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.657C>T rpoB_c.657C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.660C>T rpoB_c.660C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.669A>G rpoB_c.669A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-66C>T rpoB_c.-66C>T 1 upstream_gene_variant 759741 1 7 0 7 0 7 16810 30525 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 1.26007067420399 0.0561478031672613 154 4649 False False 0 0 1.26007067420399 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 11502 23701 0 0 0.000320664925697395 0.9997469101953 0.999449212060655 0.99990711502044 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.75038628279554 0.186840354932931 214 3890 False False 0 0 0 0 0 0 0 0 0 1.75038628279554 0 0 0.000320664925697395 0.9997469101953 0.999449212060655 0.99990711502044 4 3) Uncertain significance No change no 1 +Rifampicin rpoB c.672C>T rpoB_c.672C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.675G>C rpoB_c.675G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.678A>G rpoB_c.678A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.684C>T rpoB_c.684C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 73 581 16737 29951 0.00434265318262938 0.00340544539564538 0.00545718120423943 0.980970784750425 0.979375302798178 0.982473797615452 0.111620795107033 0.0885195887324736 0.13829336109296 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.224843552634731 0.17366053477711 0.287464817438217 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 47 437 11455 23270 0.00408624587028342 0.00300391838571967 0.00543017750550956 0.981566625891087 0.979773011492174 0.983240753200331 0.0971074380165289 0.0722254672835521 0.127037012101276 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 1 0.218483030303635 0.15799657602451 0.295902125640448 NA NA NA NA NA NA 103 5) Not assoc w R Now listed Silent mutation no 0 +Rifampicin rpoB c.687C>A rpoB_c.687C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 78 16809 30454 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.997445303288353 0.996812633501993 0.997980110410541 0.0126582278481012 0.000320427234304267 0.0685199094867721 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.0232277885320898 0.000585355533561982 0.1332789921224 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 0 77 11502 23630 0 0 0.000320664925697395 0.996752014173029 0.995942222834204 0.997435916007205 0 0 0.046778068160404 NA NA NA NA NA NA NA NA NA NA NA NA False True 1 1 1 0 0 0 0 0 0 0.100857943488805 NA NA NA NA NA NA 1 5) Not assoc w R Now listed Silent mutation no 0 +Rifampicin rpoB c.691C>T rpoB_c.691C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.696C>G rpoB_c.696C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.696C>T rpoB_c.696C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 4 8 16806 30524 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999737979824446 0.999483781433772 0.999886871715824 0.333333333333333 0.0992460911495833 0.651124493581186 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.908128049506128 0.200090516675031 3.39037213523386 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 4 6 11498 23701 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 0.9997469101953 0.999449212060655 0.99990711502044 0.4 0.121552258119827 0.737621923393055 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.37421000753754 0.285166583715735 5.7970261996096 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.69T>C rpoB_c.69T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-6T>C rpoB_c.-6T>C 1 upstream_gene_variant 759801 1 23 0 23 4 26 16806 30506 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999148434429451 0.998752506314373 0.99944365605196 0.133333333333333 0.0375534963383633 0.307218350276126 0 0 0.148185128915224 0 0 0.132274604497754 0 0 0.315822261062594 7.64106951314776e-05 48 4649 True False 0.279259238916504 0.0708394543768509 0.805163472728274 0 0 0.000219473678051534 0.999148434429451 0.998752506314373 0.99944365605196 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 16 0 16 2 17 11500 23690 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999282912220019 0.998852120448669 0.999582216212894 0.105263157894736 0.0130121643717774 0.331376664456765 0 0 0.205907214207822 0 0 0.195064322969093 0 0 0.534269924790455 0.00242486439947845 61 3890 False False 0 0 0 0 0 0 0 0.24235294117647 0.0271662646620275 1.02125663054826 0 0 0.000320720684566658 0.999282912220019 0.998852120448669 0.999582216212894 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.702G>A rpoB_c.702G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.705G>A rpoB_c.705G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.708C>T rpoB_c.708C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.714C>T rpoB_c.714C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.726T>C rpoB_c.726T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.72C>T rpoB_c.72C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.735G>C rpoB_c.735G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-73C>T rpoB_c.-73C>T 1 upstream_gene_variant 759734 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.741G>C rpoB_c.741G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.768G>C rpoB_c.768G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-77A>G rpoB_c.-77A>G 1 upstream_gene_variant 759730 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2182 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.798G>A rpoB_c.798G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.75142405620251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.801G>A rpoB_c.801G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.341150751115529 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.802C>T rpoB_c.802C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.805T>C rpoB_c.805T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.819C>G rpoB_c.819C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.828T>C rpoB_c.828T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.828T>G rpoB_c.828T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.834C>T rpoB_c.834C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 13 16810 30519 0 0 0.000219421459229958 0.999574217214725 0.999272008529012 0.999773269742809 0 0 0.24705263800047 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.595805680834415 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 12 11502 23695 0 0 0.000320664925697395 0.999493820390602 0.999115973206486 0.999738423129043 0 0 0.264648469397051 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.741560034978285 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-83A>G rpoB_c.-83A>G 1 upstream_gene_variant 759724 1 21 0 21 6 30 16804 30502 0.000356930398572278 0.000130998068917797 0.000776724091447791 0.999017424341674 0.998597606821861 0.999336965202819 0.166666666666666 0.0637201336083856 0.328115932042918 0 0 0.161097615219079 0 0 0.115703308222027 0 0 0.348633672365631 0.000126215623031884 54 4649 True False 0.363032611283027 0.123511270930481 0.886698643999517 0 0 0.000219499796783869 0.999017424341674 0.998597606821861 0.999336965202819 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 14 0 14 1 16 11501 23691 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999325093854136 0.99890422546949 0.999614185177149 0.0588235294117647 0.00148817439126663 0.28688939666722 0 0 0.231635761650116 0 0 0.205907214207822 0 0 0.621146193182118 0.00734175129762213 76 3890 False False 0 0 0 0 0 0 0 0.128744239631336 0.00307382861237757 0.828944067362951 0 0 0.000320692802708327 0.999325093854136 0.99890422546949 0.999614185177149 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.840C>G rpoB_c.840C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.849A>G rpoB_c.849A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.855A>C rpoB_c.855A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.855A>G rpoB_c.855A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.865C>T rpoB_c.865C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.868T>C rpoB_c.868T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.870G>A rpoB_c.870G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.873A>G rpoB_c.873A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.877T>C rpoB_c.877T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-87C>T rpoB_c.-87C>T 1 upstream_gene_variant 759720 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2743 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2289 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.885C>T rpoB_c.885C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-88C>A rpoB_c.-88C>A 1 upstream_gene_variant 759719 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB c.-88C>T rpoB_c.-88C>T 1 upstream_gene_variant 759719 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB c.897C>T rpoB_c.897C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.903C>T rpoB_c.903C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.904C>T rpoB_c.904C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.909C>T rpoB_c.909C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 7 16810 30525 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.26007067420399 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 7 11502 23700 0 0 0.000320664925697395 0.999704728561184 0.999391723222185 0.999881277590374 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.42986888806462 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-90A>G rpoB_c.-90A>G 1 upstream_gene_variant 759717 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2507 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.918T>C rpoB_c.918T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.924T>C rpoB_c.924T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.930C>T rpoB_c.930C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.936G>A rpoB_c.936G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 7 16809 30525 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.99977073234639 0.999527678427408 0.999907817703152 0.125 0.0031597235312519 0.526509670875206 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.2594273475944 0.00575995110596449 2.01970184240593 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 7 11501 23700 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999704728561184 0.999391723222185 0.999881277590374 0.125 0.0031597235312519 0.526509670875206 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.294384339250003 0.00653526389697788 2.29204336611244 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.939G>A rpoB_c.939G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.942C>T rpoB_c.942C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.948G>A rpoB_c.948G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.-94C>A rpoB_c.-94C>A 1 upstream_gene_variant 759713 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB c.-94C>T rpoB_c.-94C>T 1 upstream_gene_variant 759713 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB c.96G>T rpoB_c.96G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.972G>A rpoB_c.972G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.981G>T rpoB_c.981G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB c.984C>T rpoB_c.984C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoB p.Ala1002Pro rpoB_p.Ala1002Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ala1055Pro rpoB_p.Ala1055Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2710 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ala1072Gly rpoB_p.Ala1072Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2374 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1969 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Ala10Thr rpoB_p.Ala10Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Ala1153Val rpoB_p.Ala1153Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2508 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ala1172Pro rpoB_p.Ala1172Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2450 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2036 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Ala131Val rpoB_p.Ala131Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Ala286Val rpoB_p.Ala286Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 57 0 16753 30532 0.00339083878643664 0.0025691692652669 0.00439102203662388 1 0.999879187193184 1 1 0.937332519085515 1 NA NA NA NA NA NA NA NA NA NA 2404 4649 False False Inf 27.237920186879 Inf 0 0 0.000220167931279891 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 35 0 11467 23707 0.00304294905233872 0.00212041293060913 0.00422948863748576 1 0.999844409142079 1 1 0.899967564427894 1 NA NA NA NA NA NA NA NA NA NA 1999 3890 False False 0 0 0 0 0 0 0 Inf 18.5931569590347 Inf 0 0 0.000321643513580867 1 0.999844409142079 1 6 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ala29Thr rpoB_p.Ala29Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ala29Val rpoB_p.Ala29Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ala2Thr rpoB_p.Ala2Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0465743703410529 Inf 0.355062208233877 391.5 4649 False False Inf 0.341150751115529 Inf 5.94919388422868e-05 1.50620434989522e-06 0.000331422795737767 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.052853655209362 Inf 0.326658713928652 320 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 8.69489609599165e-05 2.20135467503192e-06 0.000484352330576856 1 0.999844409142079 1 1 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ala334Asp rpoB_p.Ala334Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ala334Val rpoB_p.Ala334Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ala420Ser rpoB_p.Ala420Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2728 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2273 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Ala451Gly rpoB_p.Ala451Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2436 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2026 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Ala451Val rpoB_p.Ala451Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 8 6 16802 30526 0.000475907198096371 0.00020548462525215 0.000937510381255989 0.999803484868334 0.999572318737888 0.999927879105266 0.571428571428571 0.288609400038307 0.823388910017882 0 0 0.707598226178713 0 0 0.4592581264399 0 0 4.39721399938401 0.55691846275574 773 4649 False False 2.42241003055191 0.736904648363765 8.47137542367508 0 0 0.000219525921733526 0.999803484868334 0.999572318737888 0.999927879105266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 5 5 11497 23702 0.00043470700747696 0.000141162766530747 0.00101416710312943 0.999789091829417 0.999507879904061 0.999931515258336 0.5 0.187086028447398 0.812913971552601 0 0 0.707598226178713 0 0 0.521823750104981 0 0 4.98999733770619 0.555673330963813 479.5 3890 False False 0 0 0 0 0 0 0 2.06158128207358 0.474355337248179 8.96017305588707 0 0 0.000320804359238686 0.999789091829417 0.999507879904061 0.999931515258336 NA RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Ala498Gly rpoB_p.Ala498Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ala498Val rpoB_p.Ala498Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2509 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ala527Thr rpoB_p.Ala527Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2622 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2183 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Ala527Val rpoB_p.Ala527Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ala538Pro rpoB_p.Ala538Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2422 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ala544Val rpoB_p.Ala544Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ala559Val rpoB_p.Ala559Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2693 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2242 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ala584Asp rpoB_p.Ala584Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 9 0 16801 30532 0.000535395597858417 0.000244845253515427 0.00101610321951737 1 0.999879187193184 1 1 0.663732883120057 1 NA NA NA NA NA NA NA NA NA NA 2711 4649 False False Inf 3.58631764003717 Inf 0 0 0.000219538986540545 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 7 0 11495 23707 0.000608589810467744 0.000244718560881119 0.00125352303681455 1 0.999844409142079 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 2256 3890 False False 0 0 0 0 0 0 0 Inf 2.97179240572548 Inf 0 0 0.000320860166613556 1 0.999844409142079 1 2 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ala584Gly rpoB_p.Ala584Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2678 4649 False False Inf 1.1990579265185 Inf 0 0 0.000219473678051534 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2228 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ala596Gly rpoB_p.Ala596Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2510 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2083 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ala599Thr rpoB_p.Ala599Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2744 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2290 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ala599Val rpoB_p.Ala599Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2574 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2141 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 1 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ala628Gly rpoB_p.Ala628Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ala628Pro rpoB_p.Ala628Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2336 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1934 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ala632Gly rpoB_p.Ala632Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ala632Ser rpoB_p.Ala632Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2652 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ala638Gly rpoB_p.Ala638Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2344 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1942 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ala670dup rpoB_p.Ala670dup 1 inframe_insertion (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2729 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ala686Thr rpoB_p.Ala686Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 7 16810 30525 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 1.26007067420399 0.0561478031672613 154 4649 False False 0 0 1.26007067420399 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12235036001139 0.310791984491028 261 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ala68Val rpoB_p.Ala68Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ala692Thr rpoB_p.Ala692Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 13 0 13 81 13 16729 30519 0.00481856038072575 0.00382841930617058 0.005985522878 0.999574217214725 0.999272008529012 0.999773269742809 0.861702127659574 0.775122805286942 0.924257021244692 0 0 0.24705263800047 0 0 0.24705263800047 0 0 0.598686583582136 0.00617854336645677 97 4649 False False 11.3668985685842 6.28543914415461 22.2664932263555 0 0 0.000220483756959041 0.999574217214725 0.999272008529012 0.999773269742809 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 12 0 12 23 12 11479 23695 0.00199965223439401 0.00126801715451488 0.0029989585229059 0.999493820390602 0.999115973206486 0.999738423129043 0.657142857142857 0.477890016606478 0.808675897811734 0 0 0.264648469397051 0 0 0.264648469397051 0 0 0.743045277944471 0.0120020445206666 87 3890 False False 0 0 0 0 0 0 0 3.95639138136306 1.8885044428055 8.72871461114433 0 0 0.000321307325583828 0.999493820390602 0.999115973206486 0.999738423129043 2 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ala69Pro rpoB_p.Ala69Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 16810 30526 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.54251408011679 0.0957784996510068 197 4649 False False 0 0 1.54251408011679 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 11502 23701 0 0 0.000320664925697395 0.9997469101953 0.999449212060655 0.99990711502044 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.75038628279554 0.186840354932931 214 3890 False False 0 0 0 0 0 0 0 0 0 1.75038628279554 0 0 0.000320664925697395 0.9997469101953 0.999449212060655 0.99990711502044 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ala708Ser rpoB_p.Ala708Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2391 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ala753Thr rpoB_p.Ala753Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ala753Val rpoB_p.Ala753Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 5 0 16805 30532 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 1 0.999879187193184 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 2405 4649 False False Inf 1.66460481015123 Inf 0 0 0.000219486736640675 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2000 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ala776Val rpoB_p.Ala776Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 70.7668929171829 1 1627.5 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 0 0 0.000219447565534303 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1985 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 2 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ala817Val rpoB_p.Ala817Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2490 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2070 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Ala868Val rpoB_p.Ala868Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ala902Pro rpoB_p.Ala902Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ala934Thr rpoB_p.Ala934Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2623 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ala934Val rpoB_p.Ala934Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ala942Thr rpoB_p.Ala942Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ala943Asp rpoB_p.Ala943Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Ala943Thr rpoB_p.Ala943Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 16810 30526 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.54251408011679 0.0957784996510068 197 4649 False False 0 0 1.54251408011679 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12235036001139 0.310791984491028 261 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ala943Val rpoB_p.Ala943Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0465715996825058 Inf 0.355075831185839 416 4649 False False Inf 0.0465715996825058 Inf 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0528490600080728 Inf 0.32667783805277 340.5 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Ala950Val rpoB_p.Ala950Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ala951Thr rpoB_p.Ala951Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2451 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2037 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ala960Glu rpoB_p.Ala960Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 70.7668929171829 1 1627.5 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 0 0 0.000219447565534303 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 80.2910622977969 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ala964Thr rpoB_p.Ala964Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Ala974Gly rpoB_p.Ala974Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ala974Thr rpoB_p.Ala974Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2524 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2095 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ala974Val rpoB_p.Ala974Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2491 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2071 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Ala977Ser rpoB_p.Ala977Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2679 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2229 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Ala977Thr rpoB_p.Ala977Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ala998Gly rpoB_p.Ala998Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2345 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1943 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Ala998Val rpoB_p.Ala998Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Arg1008Cys rpoB_p.Arg1008Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2423 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Arg167Cys rpoB_p.Arg167Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 8 2 16802 30530 0.000475907198096371 0.00020548462525215 0.000937510381255989 0.999934494956111 0.999763393503742 0.99999206693684 0.8 0.443904537692358 0.974789273673166 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2694 4649 False False 7.26818235924294 1.45017637426587 70.3957327614674 0 0 0.000219525921733526 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 7 1 11495 23706 0.000608589810467744 0.000244718560881119 0.00125352303681455 0.999957818365883 0.999765001636458 0.999998932054057 0.875 0.473490329124793 0.996840276468748 NA NA NA 0 0 0.975 NA NA NA NA 2243 3890 False False 0 0 0 0 0 0 0 14.4360156589821 1.85404248421684 648.546844115035 0 0 0.000320860166613556 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Arg167His rpoB_p.Arg167His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2437 4649 False False Inf 1.1990579265185 Inf 0 0 0.000219473678051534 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 0 11498 23707 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 1 0.999844409142079 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2027 3890 False False 0 0 0 0 0 0 0 Inf 1.3608069907404 Inf 0 0 0.000320776462830572 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Arg219Cys rpoB_p.Arg219Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 6 0 16804 30532 0.000356930398572278 0.000130998068917797 0.000776724091447791 1 0.999879187193184 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 2712 4649 False False Inf 2.13890645017026 Inf 0 0 0.000219499796783869 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 0 11498 23707 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 1 0.999844409142079 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2257 3890 False False 0 0 0 0 0 0 0 Inf 1.3608069907404 Inf 0 0 0.000320776462830572 1 0.999844409142079 1 4 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Arg219His rpoB_p.Arg219His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2463 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2049 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Arg219Leu rpoB_p.Arg219Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2325 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1925 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Arg219Ser rpoB_p.Arg219Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2346 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1944 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 1 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Arg224Cys rpoB_p.Arg224Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2760 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Arg224Gly rpoB_p.Arg224Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2347 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1945 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Arg224His rpoB_p.Arg224His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2392 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1986 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Arg225Gln rpoB_p.Arg225Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Arg225Gly rpoB_p.Arg225Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2476 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Arg253Met rpoB_p.Arg253Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2695 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2244 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Arg273Cys rpoB_p.Arg273Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2696 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2245 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Arg304Cys rpoB_p.Arg304Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Arg307His rpoB_p.Arg307His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Arg341His rpoB_p.Arg341His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2525 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2096 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Arg448Gln rpoB_p.Arg448Gln 1 missense_variant (see "Genomic_coordinates" sheet) 2 2 2 0 10 0 16800 30532 0.000594883997620464 0.000285305684944214 0.00109373983334496 1 0.999879187193184 1 1 0.691502892181239 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.341313245514073 Inf 0.125996614101011 221 4649 False False Inf 4.07313735951873 Inf 0.000119033448399 1.44158279220331e-05 0.000429922894532366 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1946 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 1 RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Arg448Leu rpoB_p.Arg448Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2348 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1947 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA RRDR RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Arg448Lys rpoB_p.Arg448Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 4 0 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 1.1990579265185 Inf 0.0158922163386836 112.5 4649 False False Inf 1.1990579265185 Inf 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.387090251295738 Inf 0.10671216244731 152.5 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 RRDR Assoc w RI Marker of R RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Arg459His rpoB_p.Arg459His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Arg499_Asn501dup rpoB_p.Arg499_Asn501dup 1 inframe_insertion (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2608 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2169 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Arg499Gln rpoB_p.Arg499Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Arg499Trp rpoB_p.Arg499Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2492 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2072 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Arg547Ser rpoB_p.Arg547Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Arg552Cys rpoB_p.Arg552Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 11 0 16799 30532 0.00065437239738251 0.000326704163498642 0.00117055062018267 1 0.999879187193184 1 1 0.715085847081845 1 NA NA NA NA NA NA NA NA NA NA 2477 4649 False False Inf 4.56066720991606 Inf 0 0 0.000219565120820351 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 7 0 11495 23707 0.000608589810467744 0.000244718560881119 0.00125352303681455 1 0.999844409142079 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 2062 3890 False False 0 0 0 0 0 0 0 Inf 2.97179240572548 Inf 0 0 0.000320860166613556 1 0.999844409142079 1 1 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Arg552His rpoB_p.Arg552His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 23 0 16787 30532 0.00136823319452706 0.000867533996903047 0.00205231857920666 1 0.999879187193184 1 1 0.851814871084775 1 NA NA NA NA NA NA NA NA NA NA 2315 4649 False False Inf 10.4516780546009 Inf 0 0 0.000219722057257406 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 15 0 11487 23707 0.00130412102243088 0.000730084557867185 0.00215003854003137 1 0.999844409142079 1 1 0.781980639089466 1 NA NA NA NA NA NA NA NA NA NA 1917 3890 False False 0 0 0 0 0 0 0 Inf 7.40065484717093 Inf 0 0 0.000321083590414119 1 0.999844409142079 1 5 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Arg552Leu rpoB_p.Arg552Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 37 0 16773 30532 0.00220107079119571 0.00155021590977531 0.00303262250235601 1 0.999879187193184 1 1 0.90510941258501 1 NA NA NA NA NA NA NA NA NA NA 2337 4649 False False Inf 17.3529027544178 Inf 0 0 0.000219905433549679 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 34 0 11468 23707 0.00295600765084333 0.0020479634181413 0.00412829743248029 1 0.999844409142079 1 1 0.897182075740987 1 NA NA NA NA NA NA NA NA NA NA 1935 3890 False False 0 0 0 0 0 0 0 Inf 18.040323510721 Inf 0 0 0.0003216154710464 1 0.999844409142079 1 4 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Arg578Cys rpoB_p.Arg578Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2526 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2097 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Arg578Gly rpoB_p.Arg578Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2624 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2184 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Arg578His rpoB_p.Arg578His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2326 4649 False False Inf 1.1990579265185 Inf 0 0 0.000219473678051534 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1926 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Arg607Ser rpoB_p.Arg607Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2635 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Arg661Gln rpoB_p.Arg661Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Arg665Trp rpoB_p.Arg665Trp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2561 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2129 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Arg734His rpoB_p.Arg734His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Arg791Cys rpoB_p.Arg791Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 20 0 20 1 20 16809 30512 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999344949561116 0.998988508123428 0.999599833714555 0.0476190476190476 0.00120488344836351 0.238159909936821 0 0 0.168433470983085 0 0 0.168433470983085 0 0 0.367727109247515 0.000215544297938452 58 4649 True False 0.0907609018977928 0.00219377857697153 0.56757480732083 0 0 0.000219434511605659 0.999344949561116 0.998988508123428 0.999599833714555 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 17 0 17 1 17 11501 23690 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999282912220019 0.998852120448669 0.999582216212894 0.0555555555555555 0.00140555616736942 0.272943599673368 0 0 0.195064322969093 0 0 0.195064322969093 0 0 0.499268019683028 0.0014710860243441 51 3890 False False 0 0 0 0 0 0 0 0.121165934420024 0.00290305390139272 0.77349141370224 0 0 0.000320692802708327 0.999282912220019 0.998852120448669 0.999582216212894 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Arg824Cys rpoB_p.Arg824Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2375 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Arg824His rpoB_p.Arg824His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2575 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Arg824Leu rpoB_p.Arg824Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2713 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2258 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Arg824Ser rpoB_p.Arg824Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2358 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1957 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Arg827Cys rpoB_p.Arg827Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 97 1 16713 30531 0.0057703747769185 0.00468180303810619 0.00703489705155691 0.999967247478055 0.999817528289014 0.999999170778282 0.989795918367346 0.944455028336686 0.999741688388759 NA NA NA 0 0 0.975 NA NA NA NA 2393 4649 False False 177.197810087955 31.053907442026 6766.64030732182 0 0 0.000220694811276383 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 79 0 11423 23707 0.00686837071813597 0.00544141519236754 0.00855279089705807 1 0.999844409142079 1 1 0.954378747241388 1 NA NA NA NA NA NA NA NA NA NA 1987 3890 False False 0 0 0 0 0 0 0 Inf 43.4037608282271 Inf 0 0 0.00032288224505128 1 0.999844409142079 1 21 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Arg827His rpoB_p.Arg827His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 21 0 16789 30532 0.00124925639500297 0.000773470498752546 0.00190899053306069 1 0.999879187193184 1 1 0.83890238478092 1 NA NA NA NA NA NA NA NA NA NA 2625 4649 False False Inf 9.46741729237089 Inf 0 0 0.000219695885606983 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 14 0 11488 23707 0.00121717962093548 0.000665598145642159 0.00204137811638842 1 0.999844409142079 1 1 0.768364238349883 1 NA NA NA NA NA NA NA NA NA NA 2185 3890 False False 0 0 0 0 0 0 0 Inf 6.84328477771802 Inf 0 0 0.000321055645424387 1 0.999844409142079 1 8 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Arg827Leu rpoB_p.Arg827Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 37 0 16773 30532 0.00220107079119571 0.00155021590977531 0.00303262250235601 1 0.999879187193184 1 1 0.90510941258501 1 NA NA NA NA NA NA NA NA NA NA 2626 4649 False False Inf 17.3529027544178 Inf 0 0 0.000219905433549679 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 29 0 11473 23707 0.00252130064336637 0.00168918484735422 0.00361901681244135 1 0.999844409142079 1 1 0.880555130930497 1 NA NA NA NA NA NA NA NA NA NA 2186 3890 False False 0 0 0 0 0 0 0 Inf 15.2286924418819 Inf 0 0 0.000321475331688871 1 0.999844409142079 1 1 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Arg827Ser rpoB_p.Arg827Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2376 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1970 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Arg845Gln rpoB_p.Arg845Gln 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2576 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Arg845Trp rpoB_p.Arg845Trp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2478 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2063 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Arg849His rpoB_p.Arg849His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Arg871His rpoB_p.Arg871His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2394 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1988 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Arg871Leu rpoB_p.Arg871Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2697 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2246 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Arg952Lys rpoB_p.Arg952Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 80.2910622977969 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Arg990Leu rpoB_p.Arg990Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Asn1105Ser rpoB_p.Asn1105Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Asn1155Ser rpoB_p.Asn1155Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 70.7668929171829 1 1627.5 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 0 0 0.000219447565534303 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 80.2910622977969 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asn135Asp rpoB_p.Asn135Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2542 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2112 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asn137Asp rpoB_p.Asn137Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Asn163Asp rpoB_p.Asn163Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 1 3 1 3 16809 30529 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999901742434167 0.999712876815577 0.99997973646933 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.605409800305391 0.0115361654751757 7.54087213596152 1 1627.5 4649 False False 0.605409800305391 0.0115361654751757 7.54087213596152 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 1.03056255977741 0.01747171295278 19.8057300331128 1 1214.5 3890 False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asn163Lys rpoB_p.Asn163Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 70.7668929171829 1 1627.5 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 0 0 0.000219447565534303 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 80.2980353694986 1 1214.5 3890 False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 0 0 0.000320720684566658 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asn24Asp rpoB_p.Asn24Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asn24Lys rpoB_p.Asn24Lys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2609 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2170 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asn292Ser rpoB_p.Asn292Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 7 16810 30525 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 1.26007067420399 0.0561478031672613 154 4649 False False 0 0 1.26007067420399 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 11502 23701 0 0 0.000320664925697395 0.9997469101953 0.999449212060655 0.99990711502044 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.75038628279554 0.186840354932931 214 3890 False False 0 0 0 0 0 0 0 0 0 1.75038628279554 0 0 0.000320664925697395 0.9997469101953 0.999449212060655 0.99990711502044 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asn369Asp rpoB_p.Asn369Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asn381His rpoB_p.Asn381His 1 missense_variant (see "Genomic_coordinates" sheet) 1 76 0 76 0 76 16810 30456 0 0 0.000219421459229958 0.997510808332241 0.996885381636231 0.998038314059039 0 0 0.0473787538669306 0 0 0.0473787538669306 0 0 0.0473787538669306 0 0 0.0901249331533242 4.82256208143607e-15 NA NA False True 0 0 0.0901249331533242 0 0 0.000219421459229958 0.997510808332241 0.996885381636231 0.998038314059039 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 76 0 76 0 76 11502 23631 0 0 0.000320664925697395 0.996794195807145 0.995989077362525 0.997473384583965 0 0 0.0473787538669306 0 0 0.0473787538669306 0 0 0.0473787538669306 0 0 0.102220925852213 1.31375008381805e-13 NA NA False True 1 1 1 0 0 1 0 0 0 0.102220925852213 0 0 0.000320664925697395 0.996794195807145 0.995989077362525 0.997473384583965 NA Not assoc w R 5) Not assoc w R No change yes 1 +Rifampicin rpoB p.Asn437_Asn438del rpoB_p.Asn437_Asn438del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0465715996825058 Inf 0.355075831185839 416 4649 False False Inf 0.0465715996825058 Inf 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0528490600080728 Inf 0.32667783805277 340.5 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 NA RRDR RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Asn437Asp rpoB_p.Asn437Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 15 6 16795 30526 0.000892325996430696 0.000499511372123772 0.00147132963433071 0.999803484868334 0.999572318737888 0.999927879105266 0.714285714285714 0.478248881752886 0.887190596078059 NA NA NA 0 0 0.4592581264399 NA NA NA NA 2653 4649 False False 4.54391187853527 1.66555381339007 14.2974340357539 0 0 0.00021961740805081 0.999803484868334 0.999572318737888 0.999927879105266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 6 4 11496 23703 0.000521648408972352 0.000191459062774625 0.00113506056981396 0.999831273463534 0.999568049920357 0.99995402584539 0.6 0.262378076606945 0.878447741880172 NA NA NA 0 0 0.602364635616474 NA NA NA NA 2207 3890 False False 0 0 0 0 0 0 0 3.09277139874739 0.733227146198371 14.9003695045189 0 0 0.000320832260499258 0.999831273463534 0.999568049920357 0.99995402584539 5 RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Asn437His rpoB_p.Asn437His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 6 0 16804 30532 0.000356930398572278 0.000130998068917797 0.000776724091447791 1 0.999879187193184 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 2377 4649 False False Inf 2.13890645017026 Inf 0 0 0.000219499796783869 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1971 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Asn437Ile rpoB_p.Asn437Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2479 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Asn437Ser rpoB_p.Asn437Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 3 16809 30529 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999901742434167 0.999712876815577 0.99997973646933 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2452 4649 False False 0.605409800305391 0.0115361654751757 7.54087213596152 0 0 0.000219434511605659 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2038 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Asn437Tyr rpoB_p.Asn437Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2577 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2142 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Asn438del rpoB_p.Asn438del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 12 10 2 13 2 16797 30530 0.000773349196906603 0.000411838091387593 0.00132208760075144 0.999934494956111 0.999763393503742 0.99999206693684 0.866666666666666 0.595397303396627 0.983424086559916 0.833333333333333 0.515862251314033 0.979137474539907 0.833333333333333 0.515862251314033 0.979137474539907 9.08793236887539 1.93629777519682 85.4497227985581 0.000963755246651574 68 4649 False False 11.814312079538 2.67390217818095 107.900377940009 0.000594990182661986 0.000285356617541049 0.00109393501394364 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 6 1 9 1 11493 23706 0.000782472613458529 0.000357856744032263 0.00148485474620048 0.999957818365883 0.999765001636458 0.999998932054057 0.9 0.554983882971804 0.997471421455538 0.857142857142857 0.421276802956804 0.996389703138099 0.857142857142857 0.421276802956804 0.996389703138099 12.3758809710258 1.50111689778497 567.654826972799 0.00611494468087233 67 3890 False False 0 0 0 0 0 0 0 18.5638214565387 2.57162110235215 810.478378810226 0.00052178450300026 0.000191509019039771 0.00113535660740973 0.999957818365883 0.999765001636458 0.999998932054057 2 RRDR RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Asn438His rpoB_p.Asn438His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2359 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1958 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA RRDR RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Asn487His rpoB_p.Asn487His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 1 16807 30531 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999967247478055 0.999817528289014 0.999999170778282 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 2406 4649 False False 5.44969358005592 0.437509494081317 285.652299683162 0 0 0.000219460621016169 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2001 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asn487Ser rpoB_p.Asn487Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2424 4649 False False Inf 1.1990579265185 Inf 0 0 0.000219473678051534 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2015 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 2 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asn501Lys rpoB_p.Asn501Lys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2480 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2064 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asn539Lys rpoB_p.Asn539Lys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2761 4649 False False Inf 1.1990579265185 Inf 0 0 0.000219473678051534 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 0 11498 23707 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 1 0.999844409142079 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2304 3890 False False 0 0 0 0 0 0 0 Inf 1.3608069907404 Inf 0 0 0.000320776462830572 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asn673Ser rpoB_p.Asn673Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 5 1 16805 30531 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 0.999967247478055 0.999817528289014 0.999999170778282 0.833333333333333 0.358765421002325 0.99578925548551 NA NA NA 0 0 0.975 NA NA NA NA 2774 4649 False False 9.08390360011901 1.01631102884943 428.726615606949 0 0 0.000219486736640675 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 5 0 11497 23707 0.00043470700747696 0.000141162766530747 0.00101416710312943 1 0.999844409142079 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 2314 3890 False False 0 0 0 0 0 0 0 Inf 1.88913119689894 Inf 0 0 0.000320804359238686 1 0.999844409142079 1 1 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asn673Thr rpoB_p.Asn673Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2775 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2315 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asn679Ser rpoB_p.Asn679Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2453 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2039 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Asn724Ser rpoB_p.Asn724Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asn733Ser rpoB_p.Asn733Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2714 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2259 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Asn75Thr rpoB_p.Asn75Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2543 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2113 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asn769Thr rpoB_p.Asn769Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2715 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2260 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Asn963Asp rpoB_p.Asn963Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asn963Ser rpoB_p.Asn963Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asp1006Gly rpoB_p.Asp1006Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 1 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asp103Glu rpoB_p.Asp103Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 6 16810 30526 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 1.9819581831673 0.168446574692961 237.5 4649 False False 0 0 1.54251408011679 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asp107Glu rpoB_p.Asp107Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.75142405620251 0.304356294847217 327.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12235036001139 0.310791984491028 261 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asp108Glu rpoB_p.Asp108Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2040 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asp1146Gly rpoB_p.Asp1146Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asp1148Glu rpoB_p.Asp1148Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asp114Asn rpoB_p.Asp114Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Asp114Gly rpoB_p.Asp114Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2360 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1959 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Asp118Gly rpoB_p.Asp118Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2716 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2261 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Asp120Ala rpoB_p.Asp120Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Asp120Gly rpoB_p.Asp120Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asp186Ala rpoB_p.Asp186Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2776 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2316 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asp190Ala rpoB_p.Asp190Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2654 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2208 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asp190Glu rpoB_p.Asp190Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2349 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1948 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Asp209Asn rpoB_p.Asp209Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asp211Asn rpoB_p.Asp211Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2777 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2317 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Asp211Val rpoB_p.Asp211Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asp265Ala rpoB_p.Asp265Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2745 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Asp265Gly rpoB_p.Asp265Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 12 2 16798 30530 0.000713860797144556 0.000368914962606047 0.00124663876852724 0.999934494956111 0.999763393503742 0.99999206693684 0.857142857142857 0.571870839090301 0.982205484516808 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2464 4649 False False 10.9048696273365 2.42713296283167 100.358487220483 0 0 0.000219578190293692 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 6 2 11496 23705 0.000521648408972352 0.000191459062774625 0.00113506056981396 0.999915636731767 0.999695284447545 0.999989783053538 0.75 0.349144205587175 0.968145973750055 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2050 3890 False False 0 0 0 0 0 0 0 6.18606471816283 1.10590335698881 62.723657220841 0 0 0.000320832260499258 0.999915636731767 0.999695284447545 0.999989783053538 4 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asp270Glu rpoB_p.Asp270Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.67117271135833 0.542004252564565 721 4649 False False 0.908144446427509 0.0153974005043644 17.4461131425891 0 0 0.000219434511605659 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asp301Asn rpoB_p.Asp301Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2593 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asp362His rpoB_p.Asp362His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asp363Asn rpoB_p.Asp363Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2361 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1960 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asp3Gly rpoB_p.Asp3Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 15 2 13 2 13 16808 30519 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999574217214725 0.999272008529012 0.999773269742809 0.133333333333333 0.0165759134400836 0.404602696603372 0.133333333333333 0.0165759134400836 0.404602696603372 0.133333333333333 0.0165759134400836 0.404602696603372 0.279345000549189 0.0306054143988615 1.23413702180636 0.103219016369792 214 4649 False False 0.279345000549189 0.0306054143988615 1.23413702180636 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999574217214725 0.999272008529012 0.999773269742809 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 13 2 11 2 11 11500 23696 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999536002024718 0.999169931473241 0.999768351851939 0.153846153846153 0.0192066719825284 0.454471055676557 0.153846153846153 0.0192066719825284 0.454471055676557 0.153846153846153 0.0192066719825284 0.454471055676557 0.374640316205533 0.0403463612064596 1.71705144849304 0.244178913455755 224 3890 False False 0 0 0 0 0 0 0 0.374640316205533 0.0403463612064596 1.71705144849304 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999536002024718 0.999169931473241 0.999768351851939 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asp435_Gln436del rpoB_p.Asp435_Gln436del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0465715996825058 Inf 0.355075831185839 416 4649 False False Inf 0.0465715996825058 Inf 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0528490600080728 Inf 0.32667783805277 340.5 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 NA RRDR RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Asp435_Gln436delinsGlu rpoB_p.Asp435_Gln436delinsGlu 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 3 2 1 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 3.6329128986197 0.189104318453829 214.057761575796 0.28869722941154 292 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 2 1 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 4.12278260869565 0.214595716751533 242.875597172384 0.250423653635903 226 3890 False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 NA RRDR RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Asp435Ala rpoB_p.Asp435Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 12 6 16798 30526 0.000713860797144556 0.000368914962606047 0.00124663876852724 0.999803484868334 0.999572318737888 0.999927879105266 0.666666666666666 0.409925238172074 0.866572597493876 0 0 0.707598226178713 0 0 0.4592581264399 0 0 4.39826137331397 0.556911615118374 769 4649 False False 3.63448029527324 1.26209690239599 11.8081880708029 0 0 0.000219578190293692 0.999803484868334 0.999572318737888 0.999927879105266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 7 5 11495 23702 0.000608589810467744 0.000244718560881119 0.00125352303681455 0.999789091829417 0.999507879904061 0.999931515258336 0.583333333333333 0.276669685682105 0.848347770191569 0 0 0.707598226178713 0 0 0.521823750104981 0 0 4.99086588123038 0.555674894551438 484 3890 False False 0 0 0 0 0 0 0 2.88671596346237 0.788461478042941 11.5368719534046 0 0 0.000320860166613556 0.999789091829417 0.999507879904061 0.999931515258336 6 Assoc w R RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Asp435Asn rpoB_p.Asp435Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 6 0 16804 30532 0.000356930398572278 0.000130998068917797 0.000776724091447791 1 0.999879187193184 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 2717 4649 False False Inf 2.13890645017026 Inf 0 0 0.000219499796783869 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 0 11498 23707 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 1 0.999844409142079 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2262 3890 False False 0 0 0 0 0 0 0 Inf 1.3608069907404 Inf 0 0 0.000320776462830572 1 0.999844409142079 1 NA RRDR RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Asp435del rpoB_p.Asp435del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 1 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.046570074332069 Inf 0.355083331573055 438.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0528490600080728 Inf 0.32667783805277 340.5 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 NA RRDR RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Asp435Glu rpoB_p.Asp435Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 21 0 16789 30532 0.00124925639500297 0.000773470498752546 0.00190899053306069 1 0.999879187193184 1 1 0.83890238478092 1 NA NA NA NA NA NA NA NA NA NA 2610 4649 False False Inf 9.46741729237089 Inf 0 0 0.000219695885606983 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 17 0 11485 23707 0.00147800382542166 0.000861220016155565 0.00236537605429428 1 0.999844409142079 1 1 0.804935677030906 1 NA NA NA NA NA NA NA NA NA NA 2171 3890 False False 0 0 0 0 0 0 0 Inf 8.51620393516598 Inf 0 0 0.000321139494990277 1 0.999844409142079 1 1 RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Asp435Gly rpoB_p.Asp435Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 4 4 148 8 16662 30524 0.00880428316478286 0.00744785691586025 0.0103345094254846 0.999737979824446 0.999483781433772 0.999886871715824 0.948717948717948 0.901456254831853 0.977603003443325 0.5 0.157012770487058 0.842987229512941 0.333333333333333 0.0992460911495833 0.651124493581186 1.83195294682511 0.341170562386285 9.83707323105443 0.464850282633976 445 4649 False False 33.8911295162645 16.7521814035086 79.8037231225058 0.000240009600384015 6.53982860908822e-05 0.000614404837501154 0.999737979824446 0.999483781433772 0.999886871715824 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 4 1 89 3 11413 23704 0.00773778473308989 0.0062185516748134 0.00951350434847342 0.99987345509765 0.999630227076139 0.999973902638554 0.967391304347826 0.907650118447495 0.993224149528806 0.8 0.28358206388191 0.994949236620532 0.571428571428571 0.184051567640083 0.901011721557492 8.30771926750197 0.821955324153814 408.261582013922 0.0412993663725802 112 3890 False False 0 0 0 0 0 0 0 61.6155845673062 20.4027575496019 306.984630901899 0.000350354734168345 9.54678599804893e-05 0.000896802090432916 0.99987345509765 0.999630227076139 0.999973902638554 24 Assoc w R RRDR Assoc w RI Marker of R RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Asp435His rpoB_p.Asp435His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2350 4649 False False Inf 1.1990579265185 Inf 0 0 0.000219473678051534 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 0 11498 23707 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 1 0.999844409142079 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 1949 3890 False False 0 0 0 0 0 0 0 Inf 1.3608069907404 Inf 0 0 0.000320776462830572 1 0.999844409142079 1 1 RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Asp435Leu rpoB_p.Asp435Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0465715996825058 Inf 0.355075831185839 416 4649 False False Inf 0.0465715996825058 Inf 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Asp435Phe rpoB_p.Asp435Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 43 39 4 48 4 16762 30528 0.00285544318857822 0.00210610606321703 0.00378414142684756 0.999868989912223 0.999664596427238 0.999964303043777 0.923076923076923 0.814603395616589 0.978643413508616 0.906976744186046 0.778646554618613 0.974068709733676 0.906976744186046 0.778646554618613 0.974068709733676 17.7573081971125 6.40453337771908 68.5164778988979 6.30327241687043e-14 16 4649 True False 21.8551485502923 7.99985844207186 83.3217836724503 0.00232129039938098 0.00165116916652446 0.00317192822584764 0.999868989912223 0.999664596427238 0.999964303043777 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 28 24 4 32 4 11470 23703 0.00278212484785254 0.00190372586004607 0.00392528024085978 0.999831273463534 0.999568049920357 0.99995402584539 0.888888888888888 0.73938907948917 0.968883860054984 0.857142857142857 0.673347330684204 0.959664369202908 0.857142857142857 0.673347330684204 0.959664369202908 12.3991281604184 4.25837491952599 49.21940569697 9.70076022433017e-09 18 3890 True False 0 0 0 0 0 0 0 16.5321708805579 5.86035274332018 64.3609021844604 0.00208804593701061 0.00133829439776161 0.00310526397000794 0.999831273463534 0.999568049920357 0.99995402584539 6 Assoc w R RRDR Assoc w R Marker of R 1) Assoc w R No change yes 1 +Rifampicin rpoB p.Asp435Tyr rpoB_p.Asp435Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 251 178 73 341 93 16469 30439 0.0202855443188578 0.0182079958200522 0.0225313060007231 0.99695401545919 0.996269742886194 0.997540814793275 0.785714285714285 0.744072621387622 0.823410135361259 0.709163346613545 0.648741852388666 0.764568150270608 0.656826568265682 0.596975859499861 0.713203838851354 4.50671706161098 3.41106853483132 6.00624732017219 1.49108182375715e-30 9 4649 True False 6.77695468253486 5.36842055650359 8.62356036783862 0.0106926172884003 0.0091861503863204 0.0123735063685223 0.99695401545919 0.996269742886194 0.997540814793275 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 175 122 53 220 68 11282 23639 0.0191271083289862 0.0167027398777121 0.0217989759299487 0.997131648880077 0.99636507837507 0.997771945632912 0.763888888888888 0.710525073701395 0.811732897827374 0.697142857142857 0.623268289945923 0.764199703060772 0.642105263157894 0.569506505733227 0.710192721992632 4.82310777227375 3.46336480781734 6.79571055590619 8.74525155576364e-24 9 3890 True False 0 0 0 0 0 0 0 6.77886169536064 5.13744558455912 9.0413975727829 0.0106980007015082 0.00889173670437503 0.0127601471476925 0.997131648880077 0.99636507837507 0.997771945632912 102 Assoc w R RRDR and borderline RIF Assoc w R Marker of R 1) Assoc w R No change yes 1 +Rifampicin rpoB p.Asp435Val rpoB_p.Asp435Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1096 1083 13 1154 17 15656 30515 0.0686496133254015 0.0648723136794452 0.0725769653131025 0.999443207126948 0.999108669858669 0.999675615241488 0.985482493595217 0.9768575344526 0.991520879101124 0.988138686131386 0.979802199399638 0.993669650580369 0.984545454545454 0.975370769331272 0.990972060183519 162.374439880507 94.6441279754276 305.151147297632 0 1.5 4649 True False 132.309018906489 82.0497997381375 227.030723046531 0.0646992054483541 0.0610186519587359 0.0685318740600227 0.999443207126948 0.999108669858669 0.999675615241488 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 629 624 5 683 6 10819 23701 0.0593809772213528 0.055130371834174 0.0638562502054139 0.9997469101953 0.999449212060655 0.99990711502044 0.991291727140783 0.981142718695507 0.996797704656285 0.992050874403815 0.981547553359595 0.997414048491221 0.99047619047619 0.979386634763216 0.996497137476922 273.397245586468 116.658145190822 839.742186539193 7.45799456324714e-291 2 3890 True False 0 0 0 0 0 0 0 249.372754721631 113.708086058914 682.990392710062 0.0545311544175478 0.050440928470812 0.0588498212483303 0.9997469101953 0.999449212060655 0.99990711502044 239 Assoc w R RRDR Assoc w R Marker of R 1) Assoc w R No change yes 1 +Rifampicin rpoB p.Asp49His rpoB_p.Asp49His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asp515Ala rpoB_p.Asp515Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2698 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2247 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Asp515Tyr rpoB_p.Asp515Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 10 0 10 0 10 16810 30522 0 0 0.000219421459229958 0.999672474780558 0.999397752220648 0.999842928110511 0 0 0.30849710781876 0 0 0.30849710781876 0 0 0.30849710781876 0 0 0.81016282812198 0.0177766362976847 119.5 4649 False False 0 0 0.81016282812198 0 0 0.000219421459229958 0.999672474780558 0.999397752220648 0.999842928110511 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 2.24912710990902 0.180424970179968 177 3890 False False 0 0 0 0 0 0 0 0 0 2.24912710990902 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 1 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asp520Ala rpoB_p.Asp520Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2407 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2002 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asp520Gly rpoB_p.Asp520Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2378 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1972 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Asp520Val rpoB_p.Asp520Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asp531Tyr rpoB_p.Asp531Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2730 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2274 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asp53Asn rpoB_p.Asp53Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.75142405620251 0.304356294847217 327.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12235036001139 0.310791984491028 261 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asp543Gly rpoB_p.Asp543Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.75142405620251 0.304356294847217 327.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asp545Ala rpoB_p.Asp545Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asp545Glu rpoB_p.Asp545Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 12 0 12 6 12 16804 30520 0.000356930398572278 0.000130998068917797 0.000776724091447791 0.999606969736669 0.999313555980458 0.999796899563454 0.333333333333333 0.133427402506123 0.590074761827925 0 0 0.264648469397051 0 0 0.264648469397051 0 0 0.653760625769117 0.00614395893756937 93 4649 False False 0.908117114972625 0.279591228669925 2.61508680617122 0 0 0.000219499796783869 0.999606969736669 0.999313555980458 0.999796899563454 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 5 6 11497 23701 0.00043470700747696 0.000141162766530747 0.00101416710312943 0.9997469101953 0.999449212060655 0.99990711502044 0.454545454545454 0.167488094063707 0.766206402340654 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.75114721233074 0.186829120134611 205 3890 False False 0 0 0 0 0 0 0 1.71791191905134 0.414640391314112 6.75753238418886 0 0 0.000320804359238686 0.9997469101953 0.999449212060655 0.99990711502044 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asp571Ala rpoB_p.Asp571Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 6 0 16804 30532 0.000356930398572278 0.000130998068917797 0.000776724091447791 1 0.999879187193184 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 2544 4649 False False Inf 2.13890645017026 Inf 0 0 0.000219499796783869 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2114 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 1 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asp571Tyr rpoB_p.Asp571Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0465715996825058 Inf 0.355075831185839 416 4649 False False Inf 0.0465715996825058 Inf 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asp574Glu rpoB_p.Asp574Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 14 0 16796 30532 0.000832837596668649 0.000455392489979272 0.00139696554892221 1 0.999879187193184 1 1 0.768364238349883 1 NA NA NA NA NA NA NA NA NA NA 2527 4649 False False Inf 6.02871753174659 Inf 0 0 0.000219604333908644 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 13 0 11489 23707 0.00113023821944009 0.000601937155487611 0.00193196626494298 1 0.999844409142079 1 1 0.752947361999529 1 NA NA NA NA NA NA NA NA NA NA 2098 3890 False False 0 0 0 0 0 0 0 Inf 6.28688570681876 Inf 0 0 0.000321027705298525 1 0.999844409142079 1 3 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asp594Ala rpoB_p.Asp594Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2636 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2193 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asp595Glu rpoB_p.Asp595Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2731 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2275 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asp631Gly rpoB_p.Asp631Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2680 4649 False False Inf 1.1990579265185 Inf 0 0 0.000219473678051534 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2230 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 1 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asp634Gly rpoB_p.Asp634Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 38 4 16772 30528 0.00226055919095776 0.00160018760749268 0.00310148712776189 0.999868989912223 0.999664596427238 0.999964303043777 0.904761904761904 0.77377512844722 0.973436430359239 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.75765860061185 0.304407847933878 370 4649 False False 17.2916766038635 6.22459950509847 66.7475344304288 0 0 0.000219918543569422 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 37 3 11465 23704 0.0032168318553295 0.00226592712135244 0.00443127959617942 0.99987345509765 0.999630227076139 0.999973902638554 0.925 0.796135251267101 0.984257820148958 0 0 0.707598226178713 0 0 0.707598226178713 0 0 5.00435276264611 0.555700275266654 490 3890 False False 0 0 0 0 0 0 0 25.4992876871638 8.06968080325021 129.074243628384 0 0 0.000321699613322993 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asp703Gly rpoB_p.Asp703Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Asp752Asn rpoB_p.Asp752Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Asp752Gly rpoB_p.Asp752Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2746 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2291 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Asp766His rpoB_p.Asp766His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2493 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Asp777Asn rpoB_p.Asp777Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2578 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2143 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Asp777His rpoB_p.Asp777His 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2481 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2065 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asp851Gly rpoB_p.Asp851Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asp851Pro rpoB_p.Asp851Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2494 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2073 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asp853_Glu854dup rpoB_p.Asp853_Glu854dup 1 inframe_insertion (see "Genomic_coordinates" sheet) 1 42 0 42 0 42 16810 30490 0 0 0.000219421459229958 0.998624394078344 0.998141030296228 0.999008409955253 0 0 0.0840838549403552 0 0 0.0840838549403552 0 0 0.0840838549403552 0 0 0.166544281423472 1.19228797666351e-08 24 4649 True True 0 0 0.166544281423472 0 0 0.000219421459229958 0.998624394078344 0.998141030296228 0.999008409955253 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 33 0 33 0 33 11502 23674 0 0 0.000320664925697395 0.998608006074155 0.998045673252633 0.99904162771295 0 0 0.105762810074579 0 0 0.105762810074579 0 0 0.105762810074579 0 0 0.243497202841312 2.61223722229785e-06 23 3890 True True 1 1 1 0 0 0 0 0 0 0.243497202841312 0 0 0.000320664925697395 0.998608006074155 0.998045673252633 0.99904162771295 6 5) Not assoc w R No change yes 1 +Rifampicin rpoB p.Asp875Ala rpoB_p.Asp875Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2718 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2263 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Asp903Asn rpoB_p.Asp903Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asp92Gly rpoB_p.Asp92Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 10 1 16800 30531 0.000594883997620464 0.000285305684944214 0.00109373983334496 0.999967247478055 0.999817528289014 0.999999170778282 0.909090909090909 0.587220083011617 0.997701027786185 NA NA NA 0 0 0.975 NA NA NA NA 2408 4649 False False 18.1732142857142 2.58478875004711 785.727835535391 0 0 0.000219552052902727 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 8 0 11494 23707 0.000695531211963136 0.000300327312744212 0.00137001129783907 1 0.999844409142079 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 2003 3890 False False 0 0 0 0 0 0 0 Inf 3.51981666109462 Inf 0 0 0.000320888077582845 1 0.999844409142079 1 1 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asp955Asn rpoB_p.Asp955Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 16810 30526 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.54251408011679 0.0957784996510068 197 4649 False False 0 0 1.54251408011679 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12235036001139 0.310791984491028 261 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asp993Glu rpoB_p.Asp993Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2465 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2051 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Asp993Gly rpoB_p.Asp993Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Asp997Asn rpoB_p.Asp997Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2579 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2144 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Asp997Glu rpoB_p.Asp997Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Cys1067Gly rpoB_p.Cys1067Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2747 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2292 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Cys1126Phe rpoB_p.Cys1126Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Cys116Phe rpoB_p.Cys116Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2762 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Cys681Arg rpoB_p.Cys681Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2454 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2041 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Cys681Gly rpoB_p.Cys681Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2042 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Cys701Ser rpoB_p.Cys701Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Cys701Trp rpoB_p.Cys701Trp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2699 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2248 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Cys985Ser rpoB_p.Cys985Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2495 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2074 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Gln1056Arg rpoB_p.Gln1056Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 6 0 16804 30532 0.000356930398572278 0.000130998068917797 0.000776724091447791 1 0.999879187193184 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 2395 4649 False False Inf 2.13890645017026 Inf 0 0 0.000219499796783869 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 0 11498 23707 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 1 0.999844409142079 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 1989 3890 False False 0 0 0 0 0 0 0 Inf 1.3608069907404 Inf 0 0 0.000320776462830572 1 0.999844409142079 1 3 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Gln1056His rpoB_p.Gln1056His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2351 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Gln1080Arg rpoB_p.Gln1080Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 1 16806 30531 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999967247478055 0.999817528289014 0.999999170778282 0.8 0.28358206388191 0.994949236620532 NA NA NA 0 0 0.975 NA NA NA NA 2763 4649 False False 7.26669046769011 0.71899465830523 357.208630433948 0 0 0.000219473678051534 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2305 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Gln1123Arg rpoB_p.Gln1123Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2545 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2115 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Gln172Arg rpoB_p.Gln172Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 9 0 16801 30532 0.000535395597858417 0.000244845253515427 0.00101610321951737 1 0.999879187193184 1 1 0.663732883120057 1 NA NA NA NA NA NA NA NA NA NA 2438 4649 False False Inf 3.58631764003717 Inf 0 0 0.000219538986540545 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2028 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 1 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Gln172Lys rpoB_p.Gln172Lys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2546 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2116 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Gln19Arg rpoB_p.Gln19Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 9 1 16801 30531 0.000535395597858417 0.000244845253515427 0.00101610321951737 0.999967247478055 0.999817528289014 0.999999170778282 0.9 0.554983882971804 0.997471421455538 NA NA NA 0 0 0.975 NA NA NA NA 2778 4649 False False 16.3549193500386 2.26573473572457 714.408215312578 0 0 0.000219538986540545 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 9 1 11493 23706 0.000782472613458529 0.000357856744032263 0.00148485474620048 0.999957818365883 0.999765001636458 0.999998932054057 0.9 0.554983882971804 0.997471421455538 NA NA NA 0 0 0.975 NA NA NA NA 2318 3890 False False 0 0 0 0 0 0 0 18.5638214565387 2.57162110235215 810.478378810226 0 0 0.000320915993408392 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Gln226Arg rpoB_p.Gln226Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2362 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Gln226Glu rpoB_p.Gln226Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2665 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2217 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Gln226Lys rpoB_p.Gln226Lys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2748 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2293 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Gln382Arg rpoB_p.Gln382Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2466 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2052 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Gln401Arg rpoB_p.Gln401Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2528 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2099 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Gln401Glu rpoB_p.Gln401Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2511 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2084 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Gln409Arg rpoB_p.Gln409Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 58 0 16752 30532 0.00345032718619869 0.00262098906992089 0.00445809435930149 1 0.999879187193184 1 1 0.93837899109608 1 NA NA NA NA NA NA NA NA NA NA 2379 4649 False False Inf 27.7610399710613 Inf 0 0 0.000220181072617707 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 39 0 11463 23707 0.00339071465832029 0.00241220699399044 0.00463233314821598 1 0.999844409142079 1 1 0.909748899039665 1 NA NA NA NA NA NA NA NA NA NA 1973 3890 False False 0 0 0 0 0 0 0 Inf 20.8382989384764 Inf 0 0 0.000321755732637906 1 0.999844409142079 1 12 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Gln429His rpoB_p.Gln429His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 13 1 16797 30531 0.000773349196906603 0.000411838091387593 0.00132208760075144 0.999967247478055 0.999817528289014 0.999999170778282 0.928571428571428 0.661315510068178 0.998193219340874 NA NA NA 0 0 0.975 NA NA NA NA 2425 4649 False False 23.6293981068047 3.54819873645803 999.432079931171 0 0 0.000219591261323031 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 9 1 11493 23706 0.000782472613458529 0.000357856744032263 0.00148485474620048 0.999957818365883 0.999765001636458 0.999998932054057 0.9 0.554983882971804 0.997471421455538 NA NA NA 0 0 0.975 NA NA NA NA 2016 3890 False False 0 0 0 0 0 0 0 18.5638214565387 2.57162110235215 810.478378810226 0 0 0.000320915993408392 0.999957818365883 0.999765001636458 0.999998932054057 1 RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Gln429Leu rpoB_p.Gln429Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 10 0 16800 30532 0.000594883997620464 0.000285305684944214 0.00109373983334496 1 0.999879187193184 1 1 0.691502892181239 1 NA NA NA NA NA NA NA NA NA NA 2637 4649 False False Inf 4.07313735951873 Inf 0 0 0.000219552052902727 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2194 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 1 RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Gln429Pro rpoB_p.Gln429Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2681 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2231 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Gln432_Asp435delinsHis rpoB_p.Gln432_Asp435delinsHis 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 9 9 0 9 0 16801 30532 0.000535395597858417 0.000244845253515427 0.00101610321951737 1 0.999879187193184 1 1 0.663732883120057 1 1 0.663732883120057 1 1 0.663732883120057 1 Inf 3.58631764003717 Inf 8.95962936924637e-05 51.5 4649 True False Inf 3.58631764003717 Inf 0.000535395597858417 0.000244845253515427 0.00101610321951737 1 0.999879187193184 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 8 8 0 8 0 11494 23707 0.000695531211963136 0.000300327312744212 0.00137001129783907 1 0.999844409142079 1 1 0.63058335244718 1 1 0.63058335244718 1 1 0.63058335244718 1 Inf 3.51981666109462 Inf 0.000129492710440896 39 3890 True False 0 0 0 0 0 0 0 Inf 3.51981666109462 Inf 0.000695531211963136 0.000300327312744212 0.00137001129783907 1 0.999844409142079 1 1 RRDR 1) Assoc w R UP from AwRI to AwR yes 4 +Rifampicin rpoB p.Gln432_Met434del rpoB_p.Gln432_Met434del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA RRDR RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Gln432_Met434delinsLeu rpoB_p.Gln432_Met434delinsLeu 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.341150751115529 Inf 0.126074008711323 224 4649 False False Inf 0.341150751115529 Inf 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0528490600080728 Inf 0.32667783805277 340.5 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 NA RRDR RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Gln432_Phe433del rpoB_p.Gln432_Phe433del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0465715996825058 Inf 0.355075831185839 416 4649 False False Inf 0.0465715996825058 Inf 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0528490600080728 Inf 0.32667783805277 340.5 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 NA RRDR RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Gln432Asn rpoB_p.Gln432Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0465715996825058 Inf 0.355075831185839 416 4649 False False Inf 0.0465715996825058 Inf 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0528490600080728 Inf 0.32667783805277 340.5 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 NA RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Gln432del rpoB_p.Gln432del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.341150751115529 Inf 0.126074008711323 224 4649 False False Inf 0.341150751115529 Inf 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.387090251295738 Inf 0.10671216244731 152.5 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 NA RRDR RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Gln432Glu rpoB_p.Gln432Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 8 0 16802 30532 0.000475907198096371 0.00020548462525215 0.000937510381255989 1 0.999879187193184 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 2439 4649 False False Inf 3.10133467016734 Inf 0 0 0.000219525921733526 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 5 0 11497 23707 0.00043470700747696 0.000141162766530747 0.00101416710312943 1 0.999844409142079 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 2029 3890 False False 0 0 0 0 0 0 0 Inf 1.88913119689894 Inf 0 0 0.000320804359238686 1 0.999844409142079 1 NA RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Gln432His rpoB_p.Gln432His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2655 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2209 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 1 RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Gln432Leu rpoB_p.Gln432Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 17 16 1 28 1 16782 30531 0.00166567519333729 0.00110710558710172 0.00240647153309903 0.999967247478055 0.999817528289014 0.999999170778282 0.96551724137931 0.822355704511277 0.99912735311642 0.941176470588235 0.713110603332779 0.998511825608733 0.941176470588235 0.713110603332779 0.998511825608733 29.1083303539506 4.52127386080734 1213.598528979 7.14445451187596e-07 32 4649 True False 50.9395781194136 8.42038225535838 2061.54308846754 0.000952494344564829 0.000544527727011734 0.00154633150403616 0.999967247478055 0.999817528289014 0.999999170778282 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 11 11 0 19 0 11483 23707 0.00165188662841245 0.000994827479836083 0.00257842889005257 1 0.999844409142079 1 1 0.823533088193034 1 1 0.715085847081845 1 1 0.715085847081845 1 Inf 5.17978219249293 Inf 4.48412760499868e-06 26 3890 True False 0 0 0 0 0 0 0 Inf 9.63110800980318 Inf 0.000957021054463198 0.000477835201582561 0.00171172831822756 1 0.999844409142079 1 5 Assoc w R RRDR Assoc w R Marker of R 1) Assoc w R No change yes 1 +Rifampicin rpoB p.Gln432Lys rpoB_p.Gln432Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 21 21 0 46 0 16764 30532 0.00273646638905413 0.00200411265230185 0.0036483947573427 1 0.999879187193184 1 1 0.922938172948099 1 1 0.83890238478092 1 1 0.83890238478092 1 Inf 9.4815218585939 Inf 3.50331364355371e-10 22 4649 True False Inf 21.8086610964296 Inf 0.00125111706881143 0.000774622765529972 0.00191183289078747 1 0.999879187193184 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 16 16 0 36 0 11466 23707 0.00312989045383411 0.00219307036741769 0.00433048000210719 1 0.999844409142079 1 1 0.902606244085508 1 1 0.794092785792177 1 1 0.794092785792177 1 Inf 7.97023022338724 Inf 1.6394953517415e-08 19 3890 True False 0 0 0 0 0 0 0 Inf 19.154006257125 Inf 0.00139348545549555 0.000796700513211572 0.00226194929193297 1 0.999844409142079 1 5 Assoc w R RRDR Assoc w R Marker of R 1) Assoc w R No change yes 1 +Rifampicin rpoB p.Gln432Pro rpoB_p.Gln432Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 52 51 1 69 1 16741 30531 0.0041046995835812 0.00319506284544273 0.00519192695325037 0.999967247478055 0.999817528289014 0.999999170778282 0.985714285714285 0.922956237663233 0.999638382428196 0.98076923076923 0.897446455347882 0.999513237584508 0.98076923076923 0.897446455347882 0.999513237584508 93.010035242817 15.9499850644974 3669.20693117469 3.63468731615976e-22 12 4649 True False 125.837106504987 21.8431774534963 4896.4572134741 0.00303716055264411 0.00226217619594287 0.00399139535622351 0.999967247478055 0.999817528289014 0.999999170778282 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 41 41 0 56 0 11446 23707 0.00486871848374195 0.00367981106170921 0.00631783725465721 1 0.999844409142079 1 1 0.936249903337637 1 1 0.913956163705971 1 1 0.913956163705971 1 Inf 21.9940267298338 Inf 1.10240636453921e-20 11 3890 True False 0 0 0 0 0 0 0 Inf 30.4091681311377 Inf 0.00356925219813702 0.00256253775715909 0.00483901070474949 1 0.999844409142079 1 4 Assoc w R RRDR Assoc w R Marker of R 1) Assoc w R No change yes 1 +Rifampicin rpoB p.Gln436_Asn437del rpoB_p.Gln436_Asn437del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0465715996825058 Inf 0.355075831185839 416 4649 False False Inf 0.0465715996825058 Inf 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0528490600080728 Inf 0.32667783805277 340.5 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 NA RRDR Marker of R RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Gln436Arg rpoB_p.Gln436Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2562 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2130 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA RRDR RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Gln436Asn rpoB_p.Gln436Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2594 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2156 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Gln436del rpoB_p.Gln436del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 3 3 0 3 1 16807 30531 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999967247478055 0.999817528289014 0.999999170778282 0.75 0.194120449683243 0.99369053679029 1 0.292401773821286 1 0.75 0.194120449683243 0.99369053679029 Inf 0.750552038219838 Inf 0.0447652350750259 142 4649 False False 5.44969358005592 0.437509494081317 285.652299683162 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 3 0 3 1 11499 23706 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.999957818365883 0.999765001636458 0.999998932054057 0.75 0.194120449683243 0.99369053679029 1 0.292401773821286 1 0.75 0.194120449683243 0.99369053679029 Inf 0.851753046609667 Inf 0.0348593870640737 98 3890 False False 0 0 0 0 0 0 0 6.18471171406209 0.496496186771195 324.103527365594 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.999957818365883 0.999765001636458 0.999998932054057 NA RRDR RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Gln436Pro rpoB_p.Gln436Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2719 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2264 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Gln51Pro rpoB_p.Gln51Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 2547 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 0 0 0.000219447565534303 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2117 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Gln537Lys rpoB_p.Gln537Lys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2638 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2195 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Gln975His rpoB_p.Gln975His 1 missense_variant (see "Genomic_coordinates" sheet) 1 10 0 10 62 12 16748 30520 0.00368828078524687 0.00282891765203409 0.00472574967930281 0.999606969736669 0.999313555980458 0.999796899563454 0.837837837837837 0.733864191059223 0.913301036041692 0 0 0.30849710781876 0 0 0.264648469397051 0 0 0.813108963941984 0.0178499739788221 125 4649 False False 9.41525356261444 5.02371056906941 19.2004763757803 0 0 0.000220233653660266 0.999606969736669 0.999313555980458 0.999796899563454 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 33 10 11469 23697 0.00286906624934793 0.00197573107651826 0.0040268977332274 0.999578183658835 0.999224402000993 0.999797704727851 0.767441860465116 0.613691788160416 0.882446428891298 0 0 0.369416647552819 0 0 0.30849710781876 0 0 1.21068980853138 0.0600510155453986 125 3890 False False 0 0 0 0 0 0 0 6.81838869997384 3.28087998228849 15.5109091389249 0 0 0.000321587433401291 0.999578183658835 0.999224402000993 0.999797704727851 50 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Gln980Arg rpoB_p.Gln980Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2580 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2145 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Gln980Lys rpoB_p.Gln980Lys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2720 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2265 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Glu1011Ala rpoB_p.Glu1011Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Glu1121Asp rpoB_p.Glu1121Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2529 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Glu1130Val rpoB_p.Glu1130Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Glu1140Asp rpoB_p.Glu1140Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2380 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1974 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Glu1140Gln rpoB_p.Glu1140Gln 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2440 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2030 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Glu1145Gly rpoB_p.Glu1145Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.75142405620251 0.304356294847217 327.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12235036001139 0.310791984491028 261 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Glu1169Ala rpoB_p.Glu1169Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Glu132Asp rpoB_p.Glu132Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Glu156Asp rpoB_p.Glu156Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 16809 30529 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999901742434167 0.999712876815577 0.99997973646933 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.39581433818102 0.556927644280045 795 4649 False False 0.605409800305391 0.0115361654751757 7.54087213596152 0 0 0.000219434511605659 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 3 11501 23704 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.99987345509765 0.999630227076139 0.999973902638554 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98868218084989 0.555670981350655 466 3890 False False 0 0 0 0 0 0 0 0.687012723531287 0.0130900577164196 8.55773267307823 0 0 0.000320692802708327 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Glu156Gly rpoB_p.Glu156Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2319 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 1 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Glu166Gly rpoB_p.Glu166Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2656 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2210 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Glu166Lys rpoB_p.Glu166Lys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2682 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2232 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Glu207Gly rpoB_p.Glu207Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2338 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1936 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Glu207Lys rpoB_p.Glu207Lys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 13 0 16797 30532 0.000773349196906603 0.000411838091387593 0.00132208760075144 1 0.999879187193184 1 1 0.752947361999529 1 NA NA NA NA NA NA NA NA NA NA 2496 4649 False False Inf 5.53887003766597 Inf 0 0 0.000219591261323031 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2075 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Glu240Gly rpoB_p.Glu240Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Glu250Gly rpoB_p.Glu250Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 83 7 76 20 77 16790 30455 0.00118976799524092 0.000726887900057249 0.00183690503094944 0.997478055810297 0.996848995832452 0.998009224190949 0.206185567010309 0.130728749172153 0.300316224006968 0.0843373493975903 0.0345822903785631 0.166076604755807 0.0833333333333333 0.0341623778539663 0.164189080270795 0.167067646782232 0.0649679651500694 0.361357541850972 2.30700498928732e-08 NA NA False True 0.471136963096462 0.272689759114235 0.778863391927116 0.000416741084717509 0.000167567421348711 0.00085845620074827 0.997478055810297 0.996848995832452 0.998009224190949 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 49 1 48 5 49 11497 23658 0.00043470700747696 0.000141162766530747 0.00101416710312943 0.997933099928291 0.99726835820432 0.998470516759952 0.0925925925925926 0.030752785267523 0.20300154718629 0.0204081632653061 0.000516556497593286 0.108541763968406 0.02 0.000506227983040829 0.106469545711499 0.0428698790988953 0.00106773115250365 0.250625774802446 1.25170545018102e-07 NA NA False True 0 0 0 0 0 1 0 0.209974918035405 0.0652705168295862 0.524362307225439 8.69716472429987e-05 2.20192904072632e-06 0.000484478680214183 0.997933099928291 0.99726835820432 0.998470516759952 2 Not assoc w R Previous WHO guidance 4) Not assoc w R - Interim DOWN from NotAwR to NotAwRI yes Prev. WHO 3 +Rifampicin rpoB p.Glu284Gly rpoB_p.Glu284Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2627 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2187 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Glu291Asp rpoB_p.Glu291Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Glu291Lys rpoB_p.Glu291Lys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2548 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2118 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Glu291Val rpoB_p.Glu291Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2700 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2249 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Glu320Asp rpoB_p.Glu320Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 2 5 16808 30527 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999836237390279 0.999617874429585 0.999946824656822 0.285714285714285 0.0366925661760855 0.709579136262657 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.98225896975909 0.168456568596501 274 4649 False False 0.726487386958591 0.069161301215026 4.43811993507661 0 0 0.000219447565534303 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 2 2 11500 23705 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999915636731767 0.999695284447545 0.999989783053538 0.5 0.067585986488543 0.932414013511457 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.973694203073 1 504 3890 False False 0 0 0 0 0 0 0 2.06130434782608 0.149383229063395 28.4413197127326 0 0 0.000320720684566658 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Glu330Asp rpoB_p.Glu330Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2530 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2100 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Glu337Lys rpoB_p.Glu337Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Glu344Gln rpoB_p.Glu344Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Glu360Asp rpoB_p.Glu360Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2352 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1950 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Glu360Gln rpoB_p.Glu360Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Glu360Lys rpoB_p.Glu360Lys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2732 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2276 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Glu377Val rpoB_p.Glu377Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2595 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2157 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Glu391Gly rpoB_p.Glu391Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2549 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Glu423Ala rpoB_p.Glu423Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2596 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2158 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Glu423Gly rpoB_p.Glu423Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2639 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Glu460Asp rpoB_p.Glu460Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2764 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2306 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Glu460Gly rpoB_p.Glu460Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 7 2 16803 30530 0.000416418798334324 0.000167437820935922 0.000857792460925722 0.999934494956111 0.999763393503742 0.99999206693684 0.777777777777777 0.399906426283687 0.971855026522101 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2640 4649 False False 6.35928108075938 1.21058944302618 62.7908757790311 0 0 0.000219512858481393 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 0 11498 23707 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 1 0.999844409142079 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2196 3890 False False 0 0 0 0 0 0 0 Inf 1.3608069907404 Inf 0 0 0.000320776462830572 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Glu465Gln rpoB_p.Glu465Gln 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2581 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Glu481Ala rpoB_p.Glu481Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 14 2 16796 30530 0.000832837596668649 0.000455392489979272 0.00139696554892221 0.999934494956111 0.999763393503742 0.99999206693684 0.875 0.616523763150736 0.984486396184586 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2628 4649 False False 12.723862824482 2.92167278951012 115.455078845003 0 0 0.000219604333908644 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 10 2 11492 23705 0.000869414014953921 0.000416994043678715 0.001598300185227 0.999915636731767 0.999695284447545 0.999989783053538 0.833333333333333 0.515862251314033 0.979137474539907 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2188 3890 False False 0 0 0 0 0 0 0 10.3136964845109 2.19723369471473 96.8419022617611 0 0 0.000320943914091465 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Glu507Lys rpoB_p.Glu507Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.81634838479386 0.0231376410853604 142.42572627634 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 2.06121206851578 0.0262561678399451 161.601678830082 0.54664351365823 365.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Glu530Gln rpoB_p.Glu530Gln 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2363 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1961 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Glu550_Pro551insGln rpoB_p.Glu550_Pro551insGln 1 inframe_insertion (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2456 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Glu550Gly rpoB_p.Glu550Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 13 0 16797 30532 0.000773349196906603 0.000411838091387593 0.00132208760075144 1 0.999879187193184 1 1 0.752947361999529 1 NA NA NA NA NA NA NA NA NA NA 2455 4649 False False Inf 5.53887003766597 Inf 0 0 0.000219591261323031 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 9 0 11493 23707 0.000782472613458529 0.000357856744032263 0.00148485474620048 1 0.999844409142079 1 1 0.663732883120057 1 NA NA NA NA NA NA NA NA NA NA 2043 3890 False False 0 0 0 0 0 0 0 Inf 4.07050547199104 Inf 0 0 0.000320915993408392 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Glu550Lys rpoB_p.Glu550Lys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2467 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2053 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Glu563Ala rpoB_p.Glu563Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2563 4649 False False Inf 1.1990579265185 Inf 0 0 0.000219473678051534 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 0 11498 23707 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 1 0.999844409142079 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2131 3890 False False 0 0 0 0 0 0 0 Inf 1.3608069907404 Inf 0 0 0.000320776462830572 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Glu563Asp rpoB_p.Glu563Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 10 0 10 0 12 16810 30520 0 0 0.000219421459229958 0.999606969736669 0.999313555980458 0.999796899563454 0 0 0.264648469397051 0 0 0.30849710781876 0 0 0.264648469397051 0 0 0.810109745186501 0.0177753395879348 116 4649 False False 0 0 0.653527260731835 0 0 0.000219421459229958 0.999606969736669 0.999313555980458 0.999796899563454 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 0 12 11502 23695 0 0 0.000320664925697395 0.999493820390602 0.999115973206486 0.999738423129043 0 0 0.264648469397051 0 0 0.30849710781876 0 0 0.264648469397051 0 0 0.919270022283236 0.0366171736146906 110 3890 False False 0 0 0 0 0 0 0 0 0 0.741560034978285 0 0 0.000320664925697395 0.999493820390602 0.999115973206486 0.999738423129043 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Glu563Gly rpoB_p.Glu563Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2327 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1927 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Glu563Lys rpoB_p.Glu563Lys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2749 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2294 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Glu592Asp rpoB_p.Glu592Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 6 0 16804 30532 0.000356930398572278 0.000130998068917797 0.000776724091447791 1 0.999879187193184 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 2721 4649 False False Inf 2.13890645017026 Inf 0 0 0.000219499796783869 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 5 0 11497 23707 0.00043470700747696 0.000141162766530747 0.00101416710312943 1 0.999844409142079 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 2266 3890 False False 0 0 0 0 0 0 0 Inf 1.88913119689894 Inf 0 0 0.000320804359238686 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Glu625Asp rpoB_p.Glu625Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Glu639Asp rpoB_p.Glu639Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 5 63 16805 30469 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 0.997936591117516 0.99736076501771 0.998414066866948 0.0735294117647058 0.0243052110506695 0.163312127345603 NA NA NA 0 0 0.0568723523320162 NA NA NA NA NA NA False True 0.143896138243058 0.0451600503475151 0.354016575308877 0 0 0.000219486736640675 0.997936591117516 0.99736076501771 0.998414066866948 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 4 55 11498 23652 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 0.997680010123592 0.99698127124265 0.998251802550623 0.0677966101694915 0.0187799634923867 0.164585172675823 NA NA NA 0 0 0.0648707608254246 NA NA NA NA NA NA False True 0 1 1 0 0 1 1 0.149603883679375 0.0393628169687716 0.405422274777831 0 0 0.000320776462830572 0.997680010123592 0.99698127124265 0.998251802550623 1 Not assoc w R 5) Not assoc w R No change yes 1 +Rifampicin rpoB p.Glu639Gln rpoB_p.Glu639Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Glu639Gly rpoB_p.Glu639Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.9820231071276 0.168448731581911 252 4649 False False 0 0 1.9820231071276 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12235036001139 0.310791984491028 261 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Glu639Lys rpoB_p.Glu639Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Glu645Gly rpoB_p.Glu645Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Glu646Gly rpoB_p.Glu646Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Glu70Val rpoB_p.Glu70Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Glu721Asp rpoB_p.Glu721Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Glu721Gly rpoB_p.Glu721Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Glu721Lys rpoB_p.Glu721Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 7 16810 30525 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 1.26007067420399 0.0561478031672613 154 4649 False False 0 0 1.26007067420399 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 7 11502 23700 0 0 0.000320664925697395 0.999704728561184 0.999391723222185 0.999881277590374 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 1.42986888806462 0.104255162462523 134.5 3890 False False 0 0 0 0 0 0 0 0 0 1.42986888806462 0 0 0.000320664925697395 0.999704728561184 0.999391723222185 0.999881277590374 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Glu737Gly rpoB_p.Glu737Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Glu738Ala rpoB_p.Glu738Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Glu750Gln rpoB_p.Glu750Gln 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2381 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1975 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Glu750Gly rpoB_p.Glu750Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2497 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2076 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Glu750Lys rpoB_p.Glu750Lys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2482 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Glu761Ala rpoB_p.Glu761Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2409 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2004 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Glu761Asp rpoB_p.Glu761Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 94 0 16716 30532 0.00559190957763236 0.00452112634358923 0.00683879617023608 1 0.999879187193184 1 1 0.961516649002471 1 NA NA NA NA NA NA NA NA NA NA 2779 4649 False False Inf 45.6668629088611 Inf 0 0 0.000220655207819679 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 87 0 11415 23707 0.00756390193009911 0.00606268296610934 0.00932179572860703 1 0.999844409142079 1 1 0.958485434007362 1 NA NA NA NA NA NA NA NA NA NA 2320 3890 False False 0 0 0 0 0 0 0 Inf 47.9120126647072 Inf 0 0 0.000323108494776334 1 0.999844409142079 1 174 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Glu761Gly rpoB_p.Glu761Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2629 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2189 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Glu789Lys rpoB_p.Glu789Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Glu805Ala rpoB_p.Glu805Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Glu807Ala rpoB_p.Glu807Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2657 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2211 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Glu807Gly rpoB_p.Glu807Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2611 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2172 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Glu812Gly rpoB_p.Glu812Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2410 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2005 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Glu821Val rpoB_p.Glu821Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2750 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2295 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Glu825Gly rpoB_p.Glu825Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Glu82Lys rpoB_p.Glu82Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Glu86Val rpoB_p.Glu86Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2683 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2233 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Glu896Lys rpoB_p.Glu896Lys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2684 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Glu91Gly rpoB_p.Glu91Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Glu959Lys rpoB_p.Glu959Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 80.2910622977969 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Glu976Lys rpoB_p.Glu976Lys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2364 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1962 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Gly158Ser rpoB_p.Gly158Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2597 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2159 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Gly178Arg rpoB_p.Gly178Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2598 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2160 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Gly203Arg rpoB_p.Gly203Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2531 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2101 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Gly217Ser rpoB_p.Gly217Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 2 2 16808 30530 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999934494956111 0.999763393503742 0.99999206693684 0.5 0.067585986488543 0.932414013511457 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.67174719181657 0.54201215115422 740.5 4649 False False 1.8163969538315 0.131636449523742 25.0652602654423 0 0 0.000219447565534303 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 2 2 11500 23705 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999915636731767 0.999695284447545 0.999989783053538 0.5 0.067585986488543 0.932414013511457 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.973694203073 1 504 3890 False False 0 0 0 0 0 0 0 2.06130434782608 0.149383229063395 28.4413197127326 0 0 0.000320720684566658 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Gly236Asp rpoB_p.Gly236Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Gly28Arg rpoB_p.Gly28Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 16810 30526 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.54251408011679 0.0957784996510068 197 4649 False False 0 0 1.54251408011679 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12235036001139 0.310791984491028 261 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Gly345Ser rpoB_p.Gly345Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2316 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1918 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Gly354Ser rpoB_p.Gly354Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Gly376Cys rpoB_p.Gly376Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2382 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1976 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Gly376Val rpoB_p.Gly376Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2339 4649 False False Inf 1.1990579265185 Inf 0 0 0.000219473678051534 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1937 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Gly426_Thr427del rpoB_p.Gly426_Thr427del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA RRDR RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Gly426Ser rpoB_p.Gly426Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Gly442Glu rpoB_p.Gly442Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2483 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2066 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Gly453Ala rpoB_p.Gly453Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 1 16807 30531 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999967247478055 0.999817528289014 0.999999170778282 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 2701 4649 False False 5.44969358005592 0.437509494081317 285.652299683162 0 0 0.000219460621016169 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 2250 3890 False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 0 0 0.000320720684566658 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Gly453Arg rpoB_p.Gly453Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2550 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2119 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Gly455Arg rpoB_p.Gly455Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2641 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2197 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Gly456Ser rpoB_p.Gly456Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2722 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2267 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 1 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Gly46Arg rpoB_p.Gly46Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2468 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Gly46Val rpoB_p.Gly46Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2551 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2120 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Gly492Ser rpoB_p.Gly492Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Gly504_Phe505dup rpoB_p.Gly504_Phe505dup 1 inframe_insertion (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2328 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1928 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Gly504dup rpoB_p.Gly504dup 1 inframe_insertion (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2512 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2085 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Gly516Arg rpoB_p.Gly516Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.75142405620251 0.304356294847217 327.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12235036001139 0.310791984491028 261 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Gly516Asp rpoB_p.Gly516Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Gly560Ala rpoB_p.Gly560Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Gly560Asp rpoB_p.Gly560Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Gly602Ala rpoB_p.Gly602Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2317 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1919 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Gly633Asp rpoB_p.Gly633Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2630 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Gly642Ser rpoB_p.Gly642Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Gly659Asp rpoB_p.Gly659Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Gly675Asp rpoB_p.Gly675Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 4 3 16806 30529 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999901742434167 0.999712876815577 0.99997973646933 0.571428571428571 0.184051567640083 0.901011721557492 0.333333333333333 0.00840375865961264 0.905700675949754 0.25 0.00630946320970987 0.805879550316756 0.908276805902653 0.0153996436114459 17.4486557337594 1 1627.5 4649 False False 2.42207148240707 0.409695730236002 16.540132512068 5.94990182661986e-05 1.50638358512048e-06 0.000331462229036007 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2054 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Gly693Val rpoB_p.Gly693Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Gly699Ser rpoB_p.Gly699Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2631 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Gly787Ser rpoB_p.Gly787Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2564 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2132 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Gly798Ser rpoB_p.Gly798Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2751 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2296 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Gly79Asp rpoB_p.Gly79Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2565 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Gly79Ser rpoB_p.Gly79Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2733 4649 False False Inf 1.1990579265185 Inf 0 0 0.000219473678051534 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 0 11498 23707 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 1 0.999844409142079 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2277 3890 False False 0 0 0 0 0 0 0 Inf 1.3608069907404 Inf 0 0 0.000320776462830572 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Gly836Cys rpoB_p.Gly836Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2752 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Gly836Ser rpoB_p.Gly836Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 10 0 16800 30532 0.000594883997620464 0.000285305684944214 0.00109373983334496 1 0.999879187193184 1 1 0.691502892181239 1 NA NA NA NA NA NA NA NA NA NA 2457 4649 False False Inf 4.07313735951873 Inf 0 0 0.000219552052902727 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 7 0 11495 23707 0.000608589810467744 0.000244718560881119 0.00125352303681455 1 0.999844409142079 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 2044 3890 False False 0 0 0 0 0 0 0 Inf 2.97179240572548 Inf 0 0 0.000320860166613556 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Gly876dup rpoB_p.Gly876dup 1 inframe_insertion (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2318 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Gly890Asp rpoB_p.Gly890Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Gly890Cys rpoB_p.Gly890Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2734 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2278 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Gly915Ser rpoB_p.Gly915Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2612 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Gly945Arg rpoB_p.Gly945Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Gly945Glu rpoB_p.Gly945Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 1 8 16809 30524 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999737979824446 0.999483781433772 0.999886871715824 0.111111111111111 0.00280913674659921 0.482496514917337 0 0 0.369416647552819 0 0 0.369416647552819 0 0 1.06399485657904 0.0571711480162868 174 4649 False False 0.226991492652745 0.00511932236302294 1.69341645046941 0 0 0.000219434511605659 0.999737979824446 0.999483781433772 0.999886871715824 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 1 7 11501 23700 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999704728561184 0.999391723222185 0.999881277590374 0.125 0.0031597235312519 0.526509670875206 0 0 0.409616397225003 0 0 0.409616397225003 0 0 1.42998762669841 0.104257269669983 141 3890 False False 0 0 0 0 0 0 0 0.294384339250003 0.00653526389697788 2.29204336611244 0 0 0.000320692802708327 0.999704728561184 0.999391723222185 0.999881277590374 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Gly95Arg rpoB_p.Gly95Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Gly973Asp rpoB_p.Gly973Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 8 0 16802 30532 0.000475907198096371 0.00020548462525215 0.000937510381255989 1 0.999879187193184 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 2353 4649 False False Inf 3.10133467016734 Inf 0 0 0.000219525921733526 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 0 11498 23707 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 1 0.999844409142079 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 1951 3890 False False 0 0 0 0 0 0 0 Inf 1.3608069907404 Inf 0 0 0.000320776462830572 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Gly981Asp rpoB_p.Gly981Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0465715996825058 Inf 0.355075831185839 416 4649 False False Inf 0.0465715996825058 Inf 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0528490600080728 Inf 0.32667783805277 340.5 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Gly992Arg rpoB_p.Gly992Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2582 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2146 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.His1028Arg rpoB_p.His1028Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 2 16806 30530 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999934494956111 0.999763393503742 0.99999206693684 0.666666666666666 0.222778095503512 0.956728131707258 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2319 4649 False False 3.63322622872783 0.520625747830046 40.1764939558657 0 0 0.000219473678051534 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1920 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 7 3) Uncertain significance No change no 1 +Rifampicin rpoB p.His1028Asp rpoB_p.His1028Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2340 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1938 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 1 3) Uncertain significance No change no 1 +Rifampicin rpoB p.His1028Tyr rpoB_p.His1028Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 8 0 16802 30532 0.000475907198096371 0.00020548462525215 0.000937510381255989 1 0.999879187193184 1 1 0.63058335244718 1 1 0.025 1 1 0.025 1 Inf 0.046591001217714 Inf 0.354980458434562 387 4649 False False Inf 3.10133467016734 Inf 5.95131821698506e-05 1.50674218357319e-06 0.000331541123790269 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 6 0 11496 23707 0.000521648408972352 0.000191459062774625 0.00113506056981396 1 0.999844409142079 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 2173 3890 False False 0 0 0 0 0 0 0 Inf 2.42738974088595 Inf 0 0 0.000320832260499258 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.His194Arg rpoB_p.His194Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0465715996825058 Inf 0.355075831185839 416 4649 False False Inf 0.0465715996825058 Inf 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0528490600080728 Inf 0.32667783805277 340.5 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.His194Tyr rpoB_p.His194Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 19 1 18 2 18 16808 30514 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999410454605004 0.999068423526975 0.999650561796013 0.1 0.0123485271702948 0.316982714019082 0.0526315789473684 0.00133162880417942 0.260280654195214 0.0526315789473684 0.00133162880417942 0.260280654195214 0.100858057009889 0.0024247024911593 0.638920463425162 0.00354411899038544 85 4649 False False 0.201716114019778 0.0226963968810346 0.842717806922828 5.94919388422868e-05 1.50620434989522e-06 0.000331422795737767 0.999410454605004 0.999068423526975 0.999650561796013 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 17 1 16 2 16 11500 23691 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999325093854136 0.99890422546949 0.999614185177149 0.111111111111111 0.0137512156643644 0.347120438608672 0.0588235294117647 0.00148817439126663 0.28688939666722 0.0588235294117647 0.00148817439126663 0.28688939666722 0.128755434782608 0.00307409547233019 0.829016159333583 0.0178401455329738 88 3890 False False 0 0 0 0 0 0 0 0.257510869565217 0.0287205131898964 1.09563636458773 8.69489609599165e-05 2.20135467503192e-06 0.000484352330576856 0.999325093854136 0.99890422546949 0.999614185177149 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.His317Tyr rpoB_p.His317Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.His343Arg rpoB_p.His343Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.His343Gln rpoB_p.His343Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 21 0 21 2 25 16808 30507 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999181186951395 0.998791506081474 0.999470039476732 0.074074074074074 0.00910007294230628 0.242898346845627 0 0 0.161097615219079 0 0 0.137185171530712 0 0 0.348607833125489 0.000126179528194883 53 4649 True False 0.145202284626368 0.0166586009409881 0.582444212417288 0 0 0.000219447565534303 0.999181186951395 0.998791506081474 0.999470039476732 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 17 0 17 0 18 11502 23689 0 0 0.000320664925697395 0.999240730585902 0.998800291409329 0.999549948712402 0 0 0.185301968137852 0 0 0.195064322969093 0 0 0.185301968137852 0 0 0.499202876979673 0.00147049155496426 49 3890 False False 0 0 0 0 0 0 0 0 0 0.468558999031164 0 0 0.000320664925697395 0.999240730585902 0.998800291409329 0.999549948712402 5 3) Uncertain significance No change no 1 +Rifampicin rpoB p.His445_Lys446del rpoB_p.His445_Lys446del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0465715996825058 Inf 0.355075831185839 416 4649 False False Inf 0.0465715996825058 Inf 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0528490600080728 Inf 0.32667783805277 340.5 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 NA RRDR RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.His445_Lys446delinsGln rpoB_p.His445_Lys446delinsGln 1 inframe_deletion (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2513 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2086 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 1 RRDR RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.His445Arg rpoB_p.His445Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 107 105 2 136 3 16674 30529 0.00809042236763831 0.0067921212762122 0.00956297331064792 0.999901742434167 0.999712876815577 0.99997973646933 0.97841726618705 0.938222838471464 0.995526812702801 0.981308411214953 0.934108103007567 0.997728291629584 0.972222222222222 0.920964023589417 0.994234507764957 96.1240554156171 25.9349515854291 795.929530022419 1.04365193050943e-44 8 4649 True False 83.0023589620566 27.7804831130462 407.180374411509 0.0062578222778473 0.00512104782408877 0.00757047908496733 0.999901742434167 0.999712876815577 0.99997973646933 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 80 78 2 100 2 11402 23705 0.00869414014953921 0.00707933758191786 0.0105644477979783 0.999915636731767 0.999695284447545 0.999989783053538 0.980392156862745 0.930960787801043 0.997616515418388 0.975 0.912592844069407 0.99695791383519 0.975 0.912592844069407 0.99695791383519 81.0818277495176 21.6998593520318 682.383356903037 1.395621542108e-35 8 3890 True False 0 0 0 0 0 0 0 103.95106121733 28.0079036787572 854.576032244122 0.00679442508710801 0.00537430824952319 0.00847259670367195 0.999915636731767 0.999695284447545 0.999989783053538 18 Assoc w R RRDR Assoc w R Marker of R 1) Assoc w R No change yes 1 +Rifampicin rpoB p.His445Asn rpoB_p.His445Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 104 35 69 126 83 16684 30449 0.00749553837001784 0.00624771391726386 0.00891800892589955 0.997281540678632 0.99663115887173 0.997834198362528 0.602870813397129 0.533067581829481 0.669712167066857 0.336538461538461 0.246820383683709 0.435836386933776 0.296610169491525 0.216066053368315 0.387659008065936 0.925745919895482 0.597793593097898 1.41060985906138 0.758777527277732 934 4649 False False 2.77054562050648 2.08205657264392 3.70296525884637 0.0020934266403493 0.0014585682246743 0.00291025860513074 0.997281540678632 0.99663115887173 0.997834198362528 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 74 30 44 109 50 11393 23657 0.00947661276299774 0.00778756148243545 0.0114204225886466 0.997890918294174 0.997220372511225 0.998434206102271 0.685534591194968 0.607243267114336 0.756756483660859 0.405405405405405 0.292725549183194 0.525898039544865 0.375 0.269193169946804 0.490354764407112 1.41576167183996 0.858884249048787 2.30466499347219 0.171087030491528 160 3890 False False 0 0 0 0 0 0 0 4.52666198542965 3.20742552106545 6.46472751206465 0.00262628031165193 0.00177262029582954 0.00374707295046599 0.997890918294174 0.997220372511225 0.998434206102271 29 Assoc w R RRDR and borderline RIF Assoc w R Marker of R Borderline 1) Assoc w R No change yes Borderline 1 +Rifampicin rpoB p.His445Asp rpoB_p.His445Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 574 565 9 608 10 16202 30522 0.0361689470553242 0.0333972122089067 0.0391026113306582 0.999672474780558 0.999397752220648 0.999842928110511 0.983818770226537 0.970443988762534 0.992213902415438 0.984320557491289 0.970444923051969 0.992805944634882 0.982608695652174 0.968249923052282 0.991629487192031 118.263383121425 61.7731060165735 261.032381321872 2.56178221379562e-240 3 4649 True False 114.537563263794 61.8006622924529 238.457994168971 0.0336971431979483 0.0310171379314334 0.0365404383841678 0.999672474780558 0.999397752220648 0.999842928110511 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 345 342 3 379 3 11123 23704 0.0329507911667536 0.0297637283666572 0.0363770011053901 0.99987345509765 0.999630227076139 0.999973902638554 0.992146596858638 0.977221705984364 0.998377502023634 0.991304347826087 0.974799247592159 0.998203144957359 0.991304347826087 0.974799247592159 0.998203144957359 242.943090892744 82.2329978483332 1168.16612290213 2.13723714946486e-162 4 3890 True False 0 0 0 0 0 0 0 269.226407743714 91.3350315737619 1333.75982156705 0.029829917139119 0.0267922207855551 0.0331093461189473 0.99987345509765 0.999630227076139 0.999973902638554 57 Assoc w R RRDR Assoc w R Marker of R 1) Assoc w R No change yes 1 +Rifampicin rpoB p.His445Cys rpoB_p.His445Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 71 65 6 70 8 16740 30524 0.00416418798334324 0.00324758416539656 0.00525831335367222 0.999737979824446 0.999483781433772 0.999886871715824 0.897435897435897 0.807872542581596 0.954669050221242 0.915492957746478 0.82508394417896 0.968353971866577 0.890410958904109 0.795435679151393 0.95148357627889 19.7536837913182 8.59857256995492 55.7531700785947 5.89781389541369e-23 11 4649 True False 15.9548984468339 7.66315814423299 38.3975448826257 0.00386789645938708 0.00298639113167907 0.00492733209760649 0.999737979824446 0.999483781433772 0.999886871715824 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 45 41 4 45 6 11457 23701 0.00391236306729264 0.00285509282253167 0.00523158571947652 0.9997469101953 0.999449212060655 0.99990711502044 0.88235294117647 0.761323952735925 0.955579858143685 0.911111111111111 0.78778826304566 0.97524704221653 0.872340425531914 0.742585823210755 0.951677784538378 21.2040892031072 7.67499764010907 81.4291517087046 3.65818197875947e-16 12 3890 True False 0 0 0 0 0 0 0 15.5151872217858 6.59573969159334 44.5073013739797 0.00356583753696295 0.00256008507780289 0.00483438422853982 0.9997469101953 0.999449212060655 0.99990711502044 12 Assoc w R RRDR Assoc w R 1) Assoc w R No change yes 1 +Rifampicin rpoB p.His445Gln rpoB_p.His445Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 21 2 16789 30530 0.00124925639500297 0.000773470498752546 0.00190899053306069 0.999934494956111 0.999763393503742 0.99999206693684 0.913043478260869 0.719620664090589 0.989290033962124 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.68267529884828 0.542162428962402 765 4649 False False 19.0937518613377 4.6664780007689 167.762790798543 0 0 0.000219695885606983 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 14 2 11488 23705 0.00121717962093548 0.000665598145642159 0.00204137811638842 0.999915636731767 0.999695284447545 0.999989783053538 0.875 0.616523763150736 0.984486396184586 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.9851368291416 1 1214.5 3890 False False 0 0 0 0 0 0 0 14.4442026462395 3.31609503243003 131.180560658587 0 0 0.000321055645424387 0.999915636731767 0.999695284447545 0.999989783053538 4 RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.His445Gly rpoB_p.His445Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 10 7 3 11 3 16799 30529 0.00065437239738251 0.000326704163498642 0.00117055062018267 0.999901742434167 0.999712876815577 0.99997973646933 0.785714285714285 0.492024322951528 0.953420712110132 0.7 0.347547149940002 0.933260488822265 0.7 0.347547149940002 0.933260488822265 4.24039129313252 0.967855141498337 25.4145473312692 0.040659767239718 135 4649 False False 6.6634720320654 1.75984687194931 37.2004360275228 0.000416517910270141 0.000167477676628907 0.000857996579218984 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 4 0 7 0 11495 23707 0.000608589810467744 0.000244718560881119 0.00125352303681455 1 0.999844409142079 1 1 0.590383602774996 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 1.36116200091506 Inf 0.0113768214836299 77 3890 False False 0 0 0 0 0 0 0 Inf 2.97179240572548 Inf 0.000347856335333507 9.47870168769055e-05 0.00089040868125265 1 0.999844409142079 1 2 Assoc w R RRDR Assoc w RI Marker of R RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.His445Leu rpoB_p.His445Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 210 192 18 217 20 16593 30512 0.012908982748364 0.0112574883873713 0.0147320354697028 0.999344949561116 0.998988508123428 0.999599833714555 0.915611814345991 0.872677940029197 0.947691456923561 0.914285714285714 0.867917487719984 0.948408404424392 0.90566037735849 0.858062592776517 0.941418756268669 19.6143755398862 12.0790289243034 33.7934408734774 3.75042627599845e-65 7 4649 True False 19.951497619478 12.5951221787177 33.314504891201 0.0114387846291331 0.00988537514564279 0.0131647641271214 0.999344949561116 0.998988508123428 0.999599833714555 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 131 125 6 143 8 11359 23699 0.012432620413841 0.0104882826872986 0.0146292061880366 0.999662546927068 0.999335191784523 0.999854300817065 0.947019867549668 0.898278412307352 0.976852391190032 0.954198473282442 0.902975423082724 0.983008655486213 0.93984962406015 0.88491969558806 0.973676371589129 43.4659007541743 19.4139642217439 120.824410758296 6.28085480198552e-53 7 3890 True False 0 0 0 0 0 0 0 37.2937428470816 18.4055706137824 88.0685845169836 0.0108847091605712 0.00906823293922066 0.0129551001981317 0.999662546927068 0.999335191784523 0.999854300817065 31 Assoc w R RRDR and borderline RIF Assoc w R Marker of R 1) Assoc w R No change yes 1 +Rifampicin rpoB p.His445Phe rpoB_p.His445Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.341171054461605 Inf 0.12606433451616 222 4649 False False Inf 0.750576632084797 Inf 0.000118983877684573 1.44098244078294e-05 0.000429743883731532 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA RRDR Assoc w RI Marker of R RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.His445Pro rpoB_p.His445Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 6 0 9 0 16801 30532 0.000535395597858417 0.000244845253515427 0.00101610321951737 1 0.999879187193184 1 1 0.663732883120057 1 1 0.540741873560099 1 1 0.540741873560099 1 Inf 2.13929209301164 Inf 0.0020015972551215 77 4649 False False Inf 3.58631764003717 Inf 0.000356994109597191 0.000131021453634131 0.000776862705290613 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 5 0 6 0 11496 23707 0.000521648408972352 0.000191459062774625 0.00113506056981396 1 0.999844409142079 1 1 0.540741873560099 1 1 0.478176249895018 1 1 0.478176249895018 1 Inf 1.8892954425668 Inf 0.00371720858939999 63 3890 False False 0 0 0 0 0 0 0 Inf 2.42738974088595 Inf 0.000434744804799582 0.000141175041755066 0.00101425525833895 1 0.999844409142079 1 1 RRDR Assoc w RI Marker of R RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.His445Ser rpoB_p.His445Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 18 12 6 19 7 16791 30525 0.00113027959547888 0.000680635004098699 0.00176451134196716 0.99977073234639 0.999527678427408 0.999907817703152 0.73076923076923 0.522125210306168 0.884267786708496 0.666666666666666 0.409925238172074 0.866572597493876 0.631578947368421 0.383577923314405 0.8371141278449 3.63587636233696 1.2625816496669 11.812709370275 0.0110824858741254 108 4649 False False 4.93440363460016 1.98571738254646 13.8945754951258 0.000714158186038207 0.000369068671687654 0.00124715797008423 0.99977073234639 0.999527678427408 0.999907817703152 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 9 2 14 3 11488 23704 0.00121717962093548 0.000665598145642159 0.00204137811638842 0.99987345509765 0.999630227076139 0.999973902638554 0.823529411764705 0.565682127155716 0.962014931929374 0.818181818181818 0.482244147639827 0.97716880170004 0.75 0.42814153812181 0.945139355472007 9.28516713091922 1.92132168543512 88.4094690895988 0.00115911791856425 48 3890 False False 0 0 0 0 0 0 0 9.62906220984215 2.6863954393747 52.2788648264662 0.000782812907715056 0.000358012400824787 0.0014855002765726 0.99987345509765 0.999630227076139 0.999973902638554 3 RRDR and borderline RIF Assoc w R Marker of R Borderline 1) Assoc w R No change yes Borderline 1 +Rifampicin rpoB p.His445Thr rpoB_p.His445Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 4 0 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 1.1990579265185 Inf 0.0158922163386836 112.5 4649 False False Inf 1.1990579265185 Inf 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 4 0 4 0 11498 23707 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 1 0.999844409142079 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 1.3608069907404 Inf 0.0113848189908768 78.5 3890 False False 0 0 0 0 0 0 0 Inf 1.3608069907404 Inf 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 1 0.999844409142079 1 NA RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.His445Tyr rpoB_p.His445Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 484 477 7 593 11 16217 30521 0.0352766210588935 0.0325387864831747 0.0381767233317041 0.999639722258614 0.999355455254591 0.999820137367966 0.981788079470198 0.967647910345414 0.990874493642688 0.985537190082644 0.970429170136029 0.994165949542933 0.977459016393442 0.960026477111282 0.988695168085229 128.247403518353 61.8361743772939 320.155667979046 2.75904984550552e-204 4 4649 True False 101.458923576269 56.249561119324 205.246462317668 0.0285731400503174 0.0260983224188265 0.0312139634699351 0.999639722258614 0.999355455254591 0.999820137367966 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 376 370 6 447 8 11055 23699 0.0388628064684402 0.03540448593939 0.0425569383008117 0.999662546927068 0.999335191784523 0.999854300817065 0.982417582417582 0.96565068987222 0.992379365423358 0.984042553191489 0.96559255478045 0.994121963432336 0.978835978835978 0.958725814515894 0.990819644462728 132.197045077642 60.0797555778708 364.390201555238 2.04906125664824e-171 3 3890 True False 0 0 0 0 0 0 0 119.781241519674 60.2503092122805 281.514179505647 0.0323851203501094 0.0292150086714435 0.0357963309399155 0.999662546927068 0.999335191784523 0.999854300817065 86 Assoc w R RRDR Assoc w R Marker of R 1) Assoc w R No change yes 1 +Rifampicin rpoB p.His533Arg rpoB_p.His533Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.His533Asn rpoB_p.His533Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2484 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.His593Tyr rpoB_p.His593Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2341 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1939 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.His656Gln rpoB_p.His656Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.67117271135833 0.542004252564565 721 4649 False False 0.908144446427509 0.0153974005043644 17.4461131425891 0 0 0.000219434511605659 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.9727417274169 1 1214.5 3890 False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 0 0 0.000320692802708327 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.His674Arg rpoB_p.His674Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 10 5 16800 30527 0.000594883997620464 0.000285305684944214 0.00109373983334496 0.999836237390279 0.999617874429585 0.999946824656822 0.666666666666666 0.383803732541154 0.881758896633119 NA NA NA 0 0 0.521823750104981 NA NA NA NA 2723 4649 False False 3.63416666666666 1.13152938251855 13.5563191145996 0 0 0.000219552052902727 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 7 1 11495 23706 0.000608589810467744 0.000244718560881119 0.00125352303681455 0.999957818365883 0.999765001636458 0.999998932054057 0.875 0.473490329124793 0.996840276468748 NA NA NA 0 0 0.975 NA NA NA NA 2268 3890 False False 0 0 0 0 0 0 0 14.4360156589821 1.85404248421684 648.546844115035 0 0 0.000320860166613556 0.999957818365883 0.999765001636458 0.999998932054057 7 3) Uncertain significance No change no 1 +Rifampicin rpoB p.His674Asn rpoB_p.His674Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2642 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2198 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.His674Asp rpoB_p.His674Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2411 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.His674Gln rpoB_p.His674Gln 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2329 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Rifampicin rpoB p.His674Tyr rpoB_p.His674Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 5 0 16805 30532 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 1 0.999879187193184 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 2383 4649 False False Inf 1.66460481015123 Inf 0 0 0.000219486736640675 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 5 0 11497 23707 0.00043470700747696 0.000141162766530747 0.00101416710312943 1 0.999844409142079 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 1977 3890 False False 0 0 0 0 0 0 0 Inf 1.88913119689894 Inf 0 0 0.000320804359238686 1 0.999844409142079 1 2 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.His723Asp rpoB_p.His723Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 16 0 16794 30532 0.000951814396192742 0.000544138942285324 0.00154522796648703 1 0.999879187193184 1 1 0.794092785792177 1 NA NA NA NA NA NA NA NA NA NA 2724 4649 False False Inf 7.00986495552168 Inf 0 0 0.000219630483749807 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 8 0 11494 23707 0.000695531211963136 0.000300327312744212 0.00137001129783907 1 0.999844409142079 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 2269 3890 False False 0 0 0 0 0 0 0 Inf 3.51981666109462 Inf 0 0 0.000320888077582845 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.His749Tyr rpoB_p.His749Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 2 8 16808 30524 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999737979824446 0.999483781433772 0.999886871715824 0.2 0.0252107263268333 0.556095462307641 0 0 0.369416647552819 0 0 0.369416647552819 0 0 1.0640581639262 0.0571708345078795 173 4649 False False 0.454009995240361 0.0469649977420217 2.27541152741616 0 0 0.000219447565534303 0.999737979824446 0.999483781433772 0.999886871715824 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 2 8 11500 23699 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999662546927068 0.999335191784523 0.999854300817065 0.2 0.0252107263268333 0.556095462307641 0 0 0.369416647552819 0 0 0.369416647552819 0 0 1.20752769362571 0.0599237654624583 120 3890 False False 0 0 0 0 0 0 0 0.515195652173913 0.0532924302528778 2.58225829949872 0 0 0.000320720684566658 0.999662546927068 0.999335191784523 0.999854300817065 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.His835Arg rpoB_p.His835Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 49 0 16761 30532 0.00291493158834027 0.00215723682950617 0.00385188459637647 1 0.999879187193184 1 1 0.927480736335722 1 1 0.025 1 1 0.025 1 Inf 0.0467049641944215 Inf 0.354421279654924 376 4649 False False Inf 23.2974547539588 Inf 5.96587519389094e-05 1.51042768547464e-06 0.000332351965719624 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 42 0 11460 23707 0.00365153886280646 0.00263293712034616 0.0049326488525921 1 0.999844409142079 1 1 0.915916145059644 1 1 0.025 1 1 0.025 1 Inf 0.0530381208042275 Inf 0.325892857142857 302 3890 False False 0 0 0 0 0 0 0 Inf 22.5271338378237 Inf 8.72524212546898e-05 2.20903760756344e-06 0.000486042429983591 1 0.999844409142079 1 5 3) Uncertain significance No change no 1 +Rifampicin rpoB p.His835Asp rpoB_p.His835Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2514 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2087 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.His835Pro rpoB_p.His835Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2643 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2199 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 1 3) Uncertain significance No change no 1 +Rifampicin rpoB p.His935Arg rpoB_p.His935Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ile1035Thr rpoB_p.Ile1035Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2685 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2234 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ile1035Val rpoB_p.Ile1035Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2426 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2017 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ile1046Val rpoB_p.Ile1046Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2666 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ile1106Thr rpoB_p.Ile1106Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 44 0 16766 30532 0.00261748958953004 0.00190249644002519 0.00351228223145258 1 0.999879187193184 1 1 0.919580060236424 1 1 0.025 1 1 0.025 1 Inf 0.046691036430687 Inf 0.354489524091418 377 4649 False False Inf 20.8163442087978 Inf 5.96409614122979e-05 1.50997726901817e-06 0.000332252870276926 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 28 0 11474 23707 0.00243435924187097 0.00161820482579939 0.00351641960825614 1 0.999844409142079 1 1 0.876563881499736 1 1 0.025 1 1 0.025 1 Inf 0.052973411560093 Inf 0.326161105110567 304 3890 False False 0 0 0 0 0 0 0 Inf 14.6694724449369 Inf 8.71459694989106e-05 2.20634248840103e-06 0.000485449555161539 1 0.999844409142079 1 12 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ile162Val rpoB_p.Ile162Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Ile199Thr rpoB_p.Ile199Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2441 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2031 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ile336Thr rpoB_p.Ile336Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2365 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1963 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Ile412Leu rpoB_p.Ile412Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Ile480Thr rpoB_p.Ile480Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 5 0 16805 30532 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 1 0.999879187193184 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 2442 4649 False False Inf 1.66460481015123 Inf 0 0 0.000219486736640675 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 0 11498 23707 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 1 0.999844409142079 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2032 3890 False False 0 0 0 0 0 0 0 Inf 1.3608069907404 Inf 0 0 0.000320776462830572 1 0.999844409142079 1 3 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ile480Val rpoB_p.Ile480Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 70 2 16740 30530 0.00416418798334324 0.00324758416539656 0.00525831335367222 0.999934494956111 0.999763393503742 0.99999206693684 0.972222222222222 0.903232710886584 0.996618099673826 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2498 4649 False False 63.8321385902031 17.0188634813038 536.690616606076 0 0 0.000220338891122086 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 57 2 11445 23705 0.00495565988523735 0.00375546502931022 0.00641592585290929 0.999915636731767 0.999695284447545 0.999989783053538 0.966101694915254 0.882851536111606 0.995868067027634 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2077 3890 False False 0 0 0 0 0 0 0 59.029488859764 15.6031735258855 498.576074971273 0 0 0.000322261688940343 0.999915636731767 0.999695284447545 0.999989783053538 15 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ile488Leu rpoB_p.Ile488Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2532 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2102 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ile488Met rpoB_p.Ile488Met 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2753 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2297 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ile488Val rpoB_p.Ile488Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 81 0 16729 30532 0.00481856038072575 0.00382841930617058 0.005985522878 1 0.999879187193184 1 1 0.955479737543678 1 NA NA NA NA NA NA NA NA NA NA 2725 4649 False False Inf 39.1502270867533 Inf 0 0 0.000220483756959041 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 78 0 11424 23707 0.00678142931664058 0.00536402186961339 0.0084564047469906 1 0.999844409142079 1 1 0.953807579671951 1 NA NA NA NA NA NA NA NA NA NA 2270 3890 False False 0 0 0 0 0 0 0 Inf 42.8381335414449 Inf 0 0 0.000322853986112421 1 0.999844409142079 1 4 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ile491Leu rpoB_p.Ile491Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 31 0 16779 30532 0.00184414039262343 0.00125333722248032 0.00261659758042388 1 0.999879187193184 1 1 0.88781125307763 1 NA NA NA NA NA NA NA NA NA NA 2667 4649 False False Inf 14.3908106225041 Inf 0 0 0.000219826806243681 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 9 0 11493 23707 0.000782472613458529 0.000357856744032263 0.00148485474620048 1 0.999844409142079 1 1 0.663732883120057 1 NA NA NA NA NA NA NA NA NA NA 2218 3890 False False 0 0 0 0 0 0 0 Inf 4.07050547199104 Inf 0 0 0.000320915993408392 1 0.999844409142079 1 2 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ile491Met rpoB_p.Ile491Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 2 1 18 2 16792 30530 0.00107079119571683 0.000634738299600123 0.00169178580899694 0.999934494956111 0.999763393503742 0.99999206693684 0.9 0.683017285980917 0.987651472829705 0.666666666666666 0.0942993240502461 0.991596241340387 0.5 0.067585986488543 0.932414013511457 3.63625535969509 0.189278298790646 214.254416244736 0.288407986069439 289 4649 False False 16.3631491186279 3.9166726684134 145.338678915758 0.000119090151244492 1.4422695209485e-05 0.000430127661005664 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 13 0 11489 23707 0.00113023821944009 0.000601937155487611 0.00193196626494298 1 0.999844409142079 1 1 0.752947361999529 1 1 0.025 1 1 0.025 1 Inf 0.052904255214182 Inf 0.326448276841776 310.5 3890 False False 0 0 0 0 0 0 0 Inf 6.28688570681876 Inf 8.70322019147084e-05 2.20346214890025e-06 0.000484815935079836 1 0.999844409142079 1 1 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ile491Phe rpoB_p.Ile491Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 173 96 77 116 88 16694 30444 0.00690065437239738 0.00570539866779944 0.00827097619688055 0.997117778068911 0.99645020990193 0.997687751510874 0.568627450980392 0.497633459222973 0.63759742071484 0.554913294797687 0.477570470674639 0.630341997491844 0.521739130434782 0.447003678267591 0.595762936219945 2.27364058009799 1.66596214304815 3.11141263325275 9.87158255463696e-08 27 4649 True False 2.40390123833277 1.80515494186183 3.2105447767391 0.00571768910065515 0.00463372854300135 0.00697785789394933 0.997117778068911 0.99645020990193 0.997687751510874 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance 1 123 57 66 71 73 11431 23634 0.00617283950617283 0.00482409399174769 0.00777991015810752 0.996920740709495 0.996129828541176 0.997585599137433 0.493055555555555 0.408823405228663 0.57757923523875 0.463414634146341 0.373079420287762 0.555552455809403 0.438461538461538 0.351619879055795 0.528170355702314 1.78559896930993 1.22944226052451 2.58624215963783 0.00191442476364355 56 3890 False False 0 0 0 0 0 0 0 2.0108908363822 1.4286055309336 2.82943481414802 0.0049616991643454 0.0037600442378533 0.00642373895757608 0.996920740709495 0.996129828541176 0.997585599137433 43 Assoc w R Borderline RIF Assoc w R Borderline 1) Assoc w R No change yes Borderline 1 +Rifampicin rpoB p.Ile491Ser rpoB_p.Ile491Ser 1 missense_variant (see "Genomic_coordinates" sheet) 2 2 0 2 3 2 16807 30530 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999934494956111 0.999763393503742 0.99999206693684 0.6 0.146632799634673 0.947255049473683 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.67232174050862 0.542020050820051 749.5 4649 False False 2.72475754150056 0.312074221533576 32.6324551811023 0 0 0.000219460621016169 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 0 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 80.2910622977969 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 4 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ile491Thr rpoB_p.Ile491Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 9 0 16801 30532 0.000535395597858417 0.000244845253515427 0.00101610321951737 1 0.999879187193184 1 1 0.663732883120057 1 NA NA NA NA NA NA NA NA NA NA 2396 4649 False False Inf 3.58631764003717 Inf 0 0 0.000219538986540545 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 7 0 11495 23707 0.000608589810467744 0.000244718560881119 0.00125352303681455 1 0.999844409142079 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 1990 3890 False False 0 0 0 0 0 0 0 Inf 2.97179240572548 Inf 0 0 0.000320860166613556 1 0.999844409142079 1 1 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ile491Tyr rpoB_p.Ile491Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 3 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.750576632084797 Inf 0.0447623983612152 140 4649 False False Inf 0.750576632084797 Inf 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.387090251295738 Inf 0.10671216244731 152.5 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ile491Val rpoB_p.Ile491Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 14 0 16796 30532 0.000832837596668649 0.000455392489979272 0.00139696554892221 1 0.999879187193184 1 1 0.768364238349883 1 NA NA NA NA NA NA NA NA NA NA 2458 4649 False False Inf 6.02871753174659 Inf 0 0 0.000219604333908644 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 10 0 11492 23707 0.000869414014953921 0.000416994043678715 0.001598300185227 1 0.999844409142079 1 1 0.691502892181239 1 NA NA NA NA NA NA NA NA NA NA 2045 3890 False False 0 0 0 0 0 0 0 Inf 4.62268854495848 Inf 0 0 0.000320943914091465 1 0.999844409142079 1 2 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ile506Val rpoB_p.Ile506Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ile542Lys rpoB_p.Ile542Lys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2583 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2147 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ile588Val rpoB_p.Ile588Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 8 1 16802 30531 0.000475907198096371 0.00020548462525215 0.000937510381255989 0.999967247478055 0.999817528289014 0.999999170778282 0.888888888888888 0.517503485082663 0.9971908632534 NA NA NA 0 0 0.975 NA NA NA NA 2780 4649 False False 14.5368408522794 1.94857414115003 643.047530935858 0 0 0.000219525921733526 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 6 1 11496 23706 0.000521648408972352 0.000191459062774625 0.00113506056981396 0.999957818365883 0.999765001636458 0.999998932054057 0.857142857142857 0.421276802956804 0.996389703138099 NA NA NA 0 0 0.975 NA NA NA NA 2321 3890 False False 0 0 0 0 0 0 0 12.3726513569937 1.50072525153826 567.507166587209 0 0 0.000320832260499258 0.999957818365883 0.999765001636458 0.999998932054057 6 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ile644Val rpoB_p.Ile644Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2765 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2307 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Ile717Val rpoB_p.Ile717Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2320 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1921 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Ile751Val rpoB_p.Ile751Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ile770Val rpoB_p.Ile770Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2566 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2133 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Ile783Val rpoB_p.Ile783Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ile873Phe rpoB_p.Ile873Phe 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 17 0 16793 30532 0.00101130279595478 0.000589228022589122 0.0016187015795436 1 0.999879187193184 1 1 0.804935677030906 1 NA NA NA NA NA NA NA NA NA NA 2397 4649 False False Inf 7.50125453808733 Inf 0 0 0.000219643561005912 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 15 0 11487 23707 0.00130412102243088 0.000730084557867185 0.00215003854003137 1 0.999844409142079 1 1 0.781980639089466 1 NA NA NA NA NA NA NA NA NA NA 1991 3890 False False 0 0 0 0 0 0 0 Inf 7.40065484717093 Inf 0 0 0.000321083590414119 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ile892Thr rpoB_p.Ile892Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ile909Val rpoB_p.Ile909Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2644 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2200 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 1 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ile90Leu rpoB_p.Ile90Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2330 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ile90Ser rpoB_p.Ile90Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 7 0 16803 30532 0.000416418798334324 0.000167437820935922 0.000857792460925722 1 0.999879187193184 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 2567 4649 False False Inf 2.61832748907777 Inf 0 0 0.000219512858481393 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 7 0 11495 23707 0.000608589810467744 0.000244718560881119 0.00125352303681455 1 0.999844409142079 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 2134 3890 False False 0 0 0 0 0 0 0 Inf 2.97179240572548 Inf 0 0 0.000320860166613556 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Ile910Val rpoB_p.Ile910Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ile925Val rpoB_p.Ile925Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 70 1 69 8 74 16802 30458 0.000475907198096371 0.00020548462525215 0.000937510381255989 0.99757631337613 0.996958225514198 0.998096420149625 0.0975609756097561 0.0430688434401038 0.183213938399427 0.0142857142857142 0.000361617571803165 0.0770437623367664 0.0133333333333333 0.000337513802521148 0.0720634972431675 0.0262718896473677 0.000660309975564386 0.151368188724623 3.10862944815667e-12 17 4649 True True 0.195974095747932 0.081570320077254 0.40676285001978 5.95131821698506e-05 1.50674218357319e-06 0.000331541123790269 0.99757631337613 0.996958225514198 0.998096420149625 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 69 1 68 8 73 11494 23634 0.000695531211963136 0.000300327312744212 0.00137001129783907 0.996920740709495 0.996129828541176 0.997585599137433 0.0987654320987654 0.0436129272920858 0.185364050096312 0.0144927536231884 0.000366857444740834 0.0781235357401634 0.0135135135135135 0.000342074019664797 0.0730073885096648 0.0302382828892823 0.000759035260814804 0.174306041575992 6.20859127037343e-11 17 3890 True True 0 1 1 0 0 0 0 0.225337340983145 0.0937260959345695 0.468075177658443 8.69943453675511e-05 2.20250370621981e-06 0.000484605095788619 0.996920740709495 0.996129828541176 0.997585599137433 2 Not assoc w R 5) Not assoc w R No change yes 1 +Rifampicin rpoB p.Ile965Val rpoB_p.Ile965Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.9820231071276 0.168448731581911 252 4649 False False 0 0 1.9820231071276 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12235036001139 0.310791984491028 261 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Leu1004Ile rpoB_p.Leu1004Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Leu173Pro rpoB_p.Leu173Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2412 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2006 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Leu232Val rpoB_p.Leu232Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Leu235Arg rpoB_p.Leu235Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Leu290Phe rpoB_p.Leu290Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Leu293Ser rpoB_p.Leu293Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2658 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2212 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Leu314Val rpoB_p.Leu314Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Leu316Val rpoB_p.Leu316Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Leu378Arg rpoB_p.Leu378Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 14 1 16796 30531 0.000832837596668649 0.000455392489979272 0.00139696554892221 0.999967247478055 0.999817528289014 0.999999170778282 0.933333333333333 0.680515433421696 0.998313569758647 NA NA NA 0 0 0.975 NA NA NA NA 2443 4649 False False 25.4485591807573 3.87107789366832 1070.57919951298 0 0 0.000219604333908644 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 11 0 11491 23707 0.000956355416449313 0.000477502787107626 0.00171053820723243 1 0.999844409142079 1 1 0.715085847081845 1 NA NA NA NA NA NA NA NA NA NA 2033 3890 False False 0 0 0 0 0 0 0 Inf 5.1761760609822 Inf 0 0 0.000320971839633333 1 0.999844409142079 1 1 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Leu42Val rpoB_p.Leu42Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 13 0 16797 30532 0.000773349196906603 0.000411838091387593 0.00132208760075144 1 0.999879187193184 1 1 0.752947361999529 1 NA NA NA NA NA NA NA NA NA NA 2613 4649 False False Inf 5.53887003766597 Inf 0 0 0.000219591261323031 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 12 0 11490 23707 0.0010432968179447 0.000539199208333142 0.00182171963730016 1 0.999844409142079 1 1 0.735351530602948 1 NA NA NA NA NA NA NA NA NA NA 2174 3890 False False 0 0 0 0 0 0 0 Inf 5.7314630344545 Inf 0 0 0.000320999770035263 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Leu430_Gln432del rpoB_p.Leu430_Gln432del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.341150751115529 Inf 0.126074008711323 224 4649 False False Inf 0.341150751115529 Inf 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.387090251295738 Inf 0.10671216244731 152.5 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 NA RRDR RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Leu430_Ser431insArg rpoB_p.Leu430_Ser431insArg 1 inframe_insertion (see "Genomic_coordinates" sheet) 1 3 2 1 4 1 16806 30531 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999967247478055 0.999817528289014 0.999999170778282 0.8 0.28358206388191 0.994949236620532 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 3.63334523384505 0.189126822260207 214.083198147022 0.288659793063729 290 4649 False False 7.26669046769011 0.71899465830523 357.208630433948 0.000118990956687291 1.44106817465527e-05 0.000429769447575642 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 2 1 4 1 11498 23706 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 0.999957818365883 0.999765001636458 0.999998932054057 0.8 0.28358206388191 0.994949236620532 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 4.12349973908505 0.214633041029412 242.9177724798 0.250373173935615 225 3890 False False 0 0 0 0 0 0 0 8.24699947817011 0.815939832795188 405.284913246419 0.00017391304347826 2.10623703666836e-05 0.000628091016655355 0.999957818365883 0.999765001636458 0.999998932054057 NA RRDR RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Leu430Arg rpoB_p.Leu430Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 32 3 16778 30529 0.00190362879238548 0.0013024338261299 0.00268630258659741 0.999901742434167 0.999712876815577 0.99997973646933 0.914285714285714 0.769424981341122 0.981962360185782 0 0 0.975 0 0 0.707598226178713 0 0 70.8886491814383 1 1627.5 4649 False False 19.4089084912782 6.06999401041904 99.1501430796909 0 0 0.000219839906889832 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 20 2 11482 23705 0.00173882802990784 0.00106243473911297 0.00268420764151461 0.999915636731767 0.999695284447545 0.999989783053538 0.909090909090909 0.708387258446066 0.988794413975849 1 0.025 1 0.333333333333333 0.00840375865961264 0.905700675949754 Inf 0.0529320397655836 Inf 0.326332840741161 307 3890 False False 0 0 0 0 0 0 0 20.6453579515763 5.01336511539349 181.846012041608 8.70852564660802e-05 2.20480537088392e-06 0.000485111418490829 0.999915636731767 0.999695284447545 0.999989783053538 15 RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Leu430Pro rpoB_p.Leu430Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 208 53 155 215 185 16595 30347 0.0127900059488399 0.0111463140490625 0.0146053155095648 0.993940783440324 0.993005236458017 0.994780375606786 0.5375 0.487265626940889 0.587175567910879 0.254807692307692 0.197070046159863 0.319677179083342 0.222689075630252 0.171484931680155 0.280941631497485 0.625291722147168 0.448593826423511 0.859842909083455 0.00279868583239814 78 4649 False False 2.12522658241248 1.73614836468079 2.60323812090965 0.00318356559346468 0.00238559093244735 0.00416213955383298 0.993940783440324 0.993005236458017 0.994780375606786 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 132 41 91 158 111 11344 23596 0.0137367414362719 0.0116898785876689 0.0160348515686725 0.995317838613068 0.994364168395112 0.99614673434688 0.587360594795539 0.525976429118486 0.646798046688876 0.31060606060606 0.23297610131863 0.396957231967093 0.269736842105263 0.201035548488005 0.347644860526345 0.937161921294502 0.631344636994993 1.37027105406601 0.780399980255981 495 3890 False False 0 0 0 0 0 0 0 2.96078095020267 2.30535227796618 3.81313026745898 0.00360122968818621 0.00258550662135397 0.00488233628037811 0.995317838613068 0.994364168395112 0.99614673434688 82 Assoc w R RRDR and borderline RIF Assoc w R Marker of R Borderline 1) Assoc w R No change yes Borderline 1 +Rifampicin rpoB p.Leu443_Lys446delinsProGln rpoB_p.Leu443_Lys446delinsProGln 1 inframe_deletion (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0465715996825058 Inf 0.355075831185839 416 4649 False False Inf 0.0465715996825058 Inf 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0528490600080728 Inf 0.32667783805277 340.5 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 RRDR RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Leu443Phe rpoB_p.Leu443Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2103 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Leu443Ser rpoB_p.Leu443Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2469 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2055 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA RRDR RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Leu443Trp rpoB_p.Leu443Trp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2735 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2279 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 1 RRDR RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Leu449Met rpoB_p.Leu449Met 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 10 0 16800 30532 0.000594883997620464 0.000285305684944214 0.00109373983334496 1 0.999879187193184 1 1 0.691502892181239 1 NA NA NA NA NA NA NA NA NA NA 2766 4649 False False Inf 4.07313735951873 Inf 0 0 0.000219552052902727 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2308 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Leu452Met rpoB_p.Leu452Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Leu452Pro rpoB_p.Leu452Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 259 168 91 281 102 16529 30430 0.016716240333135 0.0148323756267008 0.0187698714354209 0.996659242761692 0.995945998683493 0.997275215453407 0.733681462140992 0.686408364936955 0.777300806436464 0.648648648648648 0.587133465340455 0.706717470079089 0.622222222222222 0.561451847501461 0.680277656699658 3.39878162855959 2.61617555440423 4.43899322714438 5.64496216247457e-22 13 4649 True False 5.07179301026478 4.02652766626087 6.43043040435688 0.0100616877283344 0.00860376425171066 0.0116938580043524 0.996659242761692 0.995945998683493 0.997275215453407 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 167 115 52 182 58 11320 23649 0.0158233350721613 0.0136224588752953 0.0182739467003711 0.997553465221242 0.99683841939605 0.99814173543455 0.758333333333333 0.699083294027562 0.811081632185049 0.688622754491018 0.612492837133425 0.757914471730773 0.664739884393063 0.589131274808948 0.734592064143509 4.62020080184832 3.29927122147629 6.54465357222439 7.50530426083453e-22 10 3890 True False 0 0 0 0 0 0 0 6.55555927866455 4.84849729932049 8.97620066926235 0.0100568430257979 0.00830989531101471 0.0120595338431046 0.997553465221242 0.99683841939605 0.99814173543455 73 Assoc w R RRDR and borderline RIF Assoc w R Marker of R 1) Assoc w R No change yes 1 +Rifampicin rpoB p.Leu452Val rpoB_p.Leu452Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2767 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Leu457Met rpoB_p.Leu457Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Leu48Phe rpoB_p.Leu48Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.75142405620251 0.304356294847217 327.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12235036001139 0.310791984491028 261 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Leu490Val rpoB_p.Leu490Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2552 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2121 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Leu494Pro rpoB_p.Leu494Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2366 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Leu525Pro rpoB_p.Leu525Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2568 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Leu554Pro rpoB_p.Leu554Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 16 0 16794 30532 0.000951814396192742 0.000544138942285324 0.00154522796648703 1 0.999879187193184 1 1 0.794092785792177 1 NA NA NA NA NA NA NA NA NA NA 2321 4649 False False Inf 7.00986495552168 Inf 0 0 0.000219630483749807 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 0 11498 23707 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 1 0.999844409142079 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 1922 3890 False False 0 0 0 0 0 0 0 Inf 1.3608069907404 Inf 0 0 0.000320776462830572 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Leu554Val rpoB_p.Leu554Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2322 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1923 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Leu731Pro rpoB_p.Leu731Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 145 0 16665 30532 0.00862581796549672 0.00728368941773795 0.0101418566463131 1 0.999879187193184 1 1 0.974880335868198 1 1 0.025 1 1 0.025 1 Inf 0.0469739978388572 Inf 0.353108182550108 372 4649 False False Inf 71.0992139088194 Inf 6.00024000960038e-05 1.51912809035091e-06 0.000334266127052084 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 124 0 11378 23707 0.0107807337854286 0.00897462517736371 0.0128404426969541 1 0.999844409142079 1 1 0.970689118910225 1 1 0.025 1 1 0.025 1 Inf 0.0534203296444339 Inf 0.324317391552186 300 3890 False False 0 0 0 0 0 0 0 Inf 69.0119640814227 Inf 8.78811846383689e-05 2.2249564828868e-06 0.000489544273142204 1 0.999844409142079 1 8 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Leu775Pro rpoB_p.Leu775Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2427 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2018 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Leu778Met rpoB_p.Leu778Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Leu778Val rpoB_p.Leu778Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2398 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1992 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Leu80Val rpoB_p.Leu80Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2499 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2078 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Leu831Arg rpoB_p.Leu831Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 12 0 16798 30532 0.000713860797144556 0.000368914962606047 0.00124663876852724 1 0.999879187193184 1 1 0.735351530602948 1 NA NA NA NA NA NA NA NA NA NA 2686 4649 False False Inf 5.04894728912605 Inf 0 0 0.000219578190293692 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 12 0 11490 23707 0.0010432968179447 0.000539199208333142 0.00182171963730016 1 0.999844409142079 1 1 0.735351530602948 1 NA NA NA NA NA NA NA NA NA NA 2235 3890 False False 0 0 0 0 0 0 0 Inf 5.7314630344545 Inf 0 0 0.000320999770035263 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Leu855Ser rpoB_p.Leu855Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2342 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1940 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Leu862Arg rpoB_p.Leu862Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 17 0 16793 30532 0.00101130279595478 0.000589228022589122 0.0016187015795436 1 0.999879187193184 1 1 0.804935677030906 1 NA NA NA NA NA NA NA NA NA NA 2533 4649 False False Inf 7.50125453808733 Inf 0 0 0.000219643561005912 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 17 0 11485 23707 0.00147800382542166 0.000861220016155565 0.00236537605429428 1 0.999844409142079 1 1 0.804935677030906 1 NA NA NA NA NA NA NA NA NA NA 2104 3890 False False 0 0 0 0 0 0 0 Inf 8.51620393516598 Inf 0 0 0.000321139494990277 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Leu893Arg rpoB_p.Leu893Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Leu893Val rpoB_p.Leu893Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Leu957Val rpoB_p.Leu957Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2534 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2105 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Leu99_Ser100dup rpoB_p.Leu99_Ser100dup 1 inframe_insertion (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2485 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2067 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Leu995Met rpoB_p.Leu995Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2736 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2280 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Lys1054Arg rpoB_p.Lys1054Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 7 0 16803 30532 0.000416418798334324 0.000167437820935922 0.000857792460925722 1 0.999879187193184 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 2470 4649 False False Inf 2.61832748907777 Inf 0 0 0.000219512858481393 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 5 0 11497 23707 0.00043470700747696 0.000141162766530747 0.00101416710312943 1 0.999844409142079 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 2056 3890 False False 0 0 0 0 0 0 0 Inf 1.88913119689894 Inf 0 0 0.000320804359238686 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Lys1095Arg rpoB_p.Lys1095Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2354 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1952 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Lys1102Arg rpoB_p.Lys1102Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Lys1102Thr rpoB_p.Lys1102Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2768 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2309 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Lys157Met rpoB_p.Lys157Met 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2569 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2135 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Lys233Met rpoB_p.Lys233Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Lys274Asn rpoB_p.Lys274Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 10 0 16800 30532 0.000594883997620464 0.000285305684944214 0.00109373983334496 1 0.999879187193184 1 1 0.691502892181239 1 NA NA NA NA NA NA NA NA NA NA 2584 4649 False False Inf 4.07313735951873 Inf 0 0 0.000219552052902727 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 9 0 11493 23707 0.000782472613458529 0.000357856744032263 0.00148485474620048 1 0.999844409142079 1 1 0.663732883120057 1 NA NA NA NA NA NA NA NA NA NA 2148 3890 False False 0 0 0 0 0 0 0 Inf 4.07050547199104 Inf 0 0 0.000320915993408392 1 0.999844409142079 1 1 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Lys274Glu rpoB_p.Lys274Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2486 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2068 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Lys298Arg rpoB_p.Lys298Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Lys309Glu rpoB_p.Lys309Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Lys37Arg rpoB_p.Lys37Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 6 1 16804 30531 0.000356930398572278 0.000130998068917797 0.000776724091447791 0.999967247478055 0.999817528289014 0.999999170778282 0.857142857142857 0.421276802956804 0.996389703138099 0 0 0.975 0 0 0.975 0 0 70.7837195358556 1 1627.5 4649 False False 10.9013330159485 1.32231137693091 500.206066508325 0 0 0.000219499796783869 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 5 1 11497 23706 0.00043470700747696 0.000141162766530747 0.00101416710312943 0.999957818365883 0.999765001636458 0.999998932054057 0.833333333333333 0.358765421002325 0.99578925548551 0 0 0.975 0 0 0.975 0 0 80.3189618536173 1 1214.5 3890 False False 0 0 0 0 0 0 0 10.3096459946072 1.15337945963023 486.419600220716 0 0 0.000320804359238686 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Lys446Arg rpoB_p.Lys446Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 2645 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 0 0 0.000219447565534303 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2201 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Lys446Gln rpoB_p.Lys446Gln 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 5 1 16805 30531 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 0.999967247478055 0.999817528289014 0.999999170778282 0.833333333333333 0.358765421002325 0.99578925548551 NA NA NA 0 0 0.975 NA NA NA NA 2535 4649 False False 9.08390360011901 1.01631102884943 428.726615606949 0 0 0.000219486736640675 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 1 11498 23706 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 0.999957818365883 0.999765001636458 0.999998932054057 0.8 0.28358206388191 0.994949236620532 NA NA NA 0 0 0.975 NA NA NA NA 2106 3890 False False 0 0 0 0 0 0 0 8.24699947817011 0.815939832795188 405.284913246419 0 0 0.000320776462830572 0.999957818365883 0.999765001636458 0.999998932054057 NA RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Lys446Glu rpoB_p.Lys446Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 70.7668929171829 1 1627.5 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 0 0 0.000219447565534303 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Lys446Thr rpoB_p.Lys446Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2599 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2161 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Lys711Arg rpoB_p.Lys711Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Lys799Gln rpoB_p.Lys799Gln 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 5 0 16805 30532 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 1 0.999879187193184 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 2399 4649 False False Inf 1.66460481015123 Inf 0 0 0.000219486736640675 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 5 0 11497 23707 0.00043470700747696 0.000141162766530747 0.00101416710312943 1 0.999844409142079 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 1993 3890 False False 0 0 0 0 0 0 0 Inf 1.88913119689894 Inf 0 0 0.000320804359238686 1 0.999844409142079 1 1 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Lys803Thr rpoB_p.Lys803Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2413 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2007 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Lys822Thr rpoB_p.Lys822Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2444 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Lys832Asn rpoB_p.Lys832Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2659 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2213 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Lys832Gln rpoB_p.Lys832Gln 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2737 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2281 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Lys832Glu rpoB_p.Lys832Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 7 0 16803 30532 0.000416418798334324 0.000167437820935922 0.000857792460925722 1 0.999879187193184 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 2536 4649 False False Inf 2.61832748907777 Inf 0 0 0.000219512858481393 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 0 11498 23707 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 1 0.999844409142079 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2107 3890 False False 0 0 0 0 0 0 0 Inf 1.3608069907404 Inf 0 0 0.000320776462830572 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Lys891Glu rpoB_p.Lys891Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 69 0 16741 30532 0.0041046995835812 0.00319506284544273 0.00519192695325037 1 0.999879187193184 1 1 0.94794194213692 1 NA NA NA NA NA NA NA NA NA NA 2515 4649 False False Inf 33.1804124052076 Inf 0 0 0.00022032573093953 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 38 0 11464 23707 0.0033037732568249 0.0023389751642717 0.00453189495926602 1 0.999844409142079 1 1 0.907487238584121 1 NA NA NA NA NA NA NA NA NA NA 2088 3890 False False 0 0 0 0 0 0 0 Inf 20.2764910499709 Inf 0 0 0.000321727670533211 1 0.999844409142079 1 5 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Lys891Thr rpoB_p.Lys891Thr 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0465715996825058 Inf 0.355075831185839 416 4649 False False Inf 0.0465715996825058 Inf 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Lys944Asn rpoB_p.Lys944Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Lys944Glu rpoB_p.Lys944Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 52 16808 30480 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.998296868858902 0.997767162428657 0.99872776667873 0.037037037037037 0.00451725629446049 0.127471772230947 NA NA NA 0 0 0.0684822087033195 NA NA NA NA NA NA False True 0.0697470069197817 0.00821732408693178 0.265000421777123 0 0 0.000219447565534303 0.998296868858902 0.997767162428657 0.99872776667873 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 2 49 11500 23658 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.997933099928291 0.99726835820432 0.998470516759952 0.0392156862745098 0.00478499269470729 0.134586491129664 NA NA NA 0 0 0.0725192636642774 NA NA NA NA NA NA False True 0 1 1 0 0 1 0 0.0839680567879325 0.0098858515305454 0.320070404448227 0 0 0.000320720684566658 0.997933099928291 0.99726835820432 0.998470516759952 2 Not assoc w R 5) Not assoc w R No change yes 1 +Rifampicin rpoB p.Met1003Thr rpoB_p.Met1003Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Met1022Ile rpoB_p.Met1022Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Met1025Leu rpoB_p.Met1025Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2367 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1964 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Met1070Ile rpoB_p.Met1070Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Met1070Thr rpoB_p.Met1070Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2445 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Met121Ile rpoB_p.Met121Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 1 5 16809 30527 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999836237390279 0.999617874429585 0.999946824656822 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.602364635616474 0 0 0.521823750104981 0 0 2.75149762911492 0.304356889326431 345.5 4649 False False 0.363222083407698 0.00768325476784986 3.24674897733262 0 0 0.000219434511605659 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.9727417274169 1 1214.5 3890 False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 0 0 0.000320692802708327 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Met153Thr rpoB_p.Met153Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2516 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2089 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Met153Val rpoB_p.Met153Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Met154Ile rpoB_p.Met154Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Met349_Thr350del rpoB_p.Met349_Thr350del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Met387Leu rpoB_p.Met387Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2384 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1978 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Met387Val rpoB_p.Met387Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2343 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1941 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Met390Thr rpoB_p.Met390Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 19 1 18 3 18 16807 30514 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999410454605004 0.999068423526975 0.999650561796013 0.142857142857142 0.0304889676215155 0.363423987016981 0.0526315789473684 0.00133162880417942 0.260280654195214 0.0526315789473684 0.00133162880417942 0.260280654195214 0.100864057965265 0.00242484646942508 0.638958476424393 0.00354472180564847 86 4649 False False 0.302592173895797 0.0570930355428442 1.03674460439863 5.94954783436458e-05 1.50629396217601e-06 0.000331442511213996 0.999410454605004 0.999068423526975 0.999650561796013 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 12 0 12 2 12 11500 23695 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999493820390602 0.999115973206486 0.999738423129043 0.142857142857142 0.0177945154831915 0.428129160909698 0 0 0.264648469397051 0 0 0.264648469397051 0 0 0.741688951315746 0.0119709800226774 85 3890 False False 0 0 0 0 0 0 0 0.343405797101449 0.0373242917489932 1.54295916091394 0 0 0.000320720684566658 0.999493820390602 0.999115973206486 0.999738423129043 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Met434_Asn437delinsIle rpoB_p.Met434_Asn437delinsIle 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0465715996825058 Inf 0.355075831185839 416 4649 False False Inf 0.0465715996825058 Inf 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0528490600080728 Inf 0.32667783805277 340.5 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 NA RRDR RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Met434_Asp435del rpoB_p.Met434_Asp435del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 4 4 0 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 1.1990579265185 Inf 0.0158922163386836 112.5 4649 False False Inf 1.1990579265185 Inf 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 3 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.851788978516443 Inf 0.0348564168530142 96 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 NA RRDR RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Met434_Asp435insVal rpoB_p.Met434_Asp435insVal 1 inframe_insertion (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2585 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2149 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA RRDR RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Met434Arg rpoB_p.Met434Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2553 4649 False False Inf 1.1990579265185 Inf 0 0 0.000219473678051534 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 0 11498 23707 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 1 0.999844409142079 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2122 3890 False False 0 0 0 0 0 0 0 Inf 1.3608069907404 Inf 0 0 0.000320776462830572 1 0.999844409142079 1 NA RRDR RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Met434Ile rpoB_p.Met434Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 33 2 16777 30530 0.00196311719214753 0.00135169297871974 0.00275585192368924 0.999934494956111 0.999763393503742 0.99999206693684 0.942857142857142 0.80842859365476 0.99300323637169 1 0.025 1 0.333333333333333 0.00840375865961264 0.905700675949754 Inf 0.0466573680512858 Inf 0.354654603872495 379 4649 False False 30.0259283542945 7.67790829405535 256.475195375433 5.96018595780188e-05 1.50898729778041e-06 0.000332035068175461 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 22 2 11480 23705 0.00191271083289862 0.00119906180010764 0.00289444346770694 0.999915636731767 0.999695284447545 0.999989783053538 0.916666666666666 0.730027198442396 0.989743658718749 1 0.025 1 0.333333333333333 0.00840375865961264 0.905700675949754 Inf 0.0529412606329625 Inf 0.326294548968339 306 3890 False False 0 0 0 0 0 0 0 22.713850174216 5.58176817799614 198.721420005626 8.71004267920912e-05 2.20518944943803e-06 0.00048519590848953 0.999915636731767 0.999695284447545 0.999989783053538 9 RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Met434Leu rpoB_p.Met434Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2781 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2322 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Met434Thr rpoB_p.Met434Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2614 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2175 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA RRDR RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Met434Val rpoB_p.Met434Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 12 2 16798 30530 0.000713860797144556 0.000368914962606047 0.00124663876852724 0.999934494956111 0.999763393503742 0.99999206693684 0.857142857142857 0.571870839090301 0.982205484516808 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2769 4649 False False 10.9048696273365 2.42713296283167 100.358487220483 0 0 0.000219578190293692 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 10 2 11492 23705 0.000869414014953921 0.000416994043678715 0.001598300185227 0.999915636731767 0.999695284447545 0.999989783053538 0.833333333333333 0.515862251314033 0.979137474539907 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2310 3890 False False 0 0 0 0 0 0 0 10.3136964845109 2.19723369471473 96.8419022617611 0 0 0.000320943914091465 0.999915636731767 0.999695284447545 0.999989783053538 1 RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Met477Arg rpoB_p.Met477Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2615 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2176 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Met573Thr rpoB_p.Met573Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Met587Ile rpoB_p.Met587Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.75142405620251 0.304356294847217 327.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Met587Thr rpoB_p.Met587Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2428 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2019 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Met624Thr rpoB_p.Met624Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Met655Thr rpoB_p.Met655Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 25 0 25 0 25 16810 30507 0 0 0.000219421459229958 0.999181186951395 0.998791506081474 0.999470039476732 0 0 0.137185171530712 0 0 0.137185171530712 0 0 0.137185171530712 0 0 0.288608378185891 2.40786800763829e-05 41 4649 True False 0 0 0.288608378185891 0 0 0.000219421459229958 0.999181186951395 0.998791506081474 0.999470039476732 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 25 0 25 0 25 11502 23682 0 0 0.000320664925697395 0.998945459147087 0.998443680572118 0.999317444144018 0 0 0.137185171530712 0 0 0.137185171530712 0 0 0.137185171530712 0 0 0.327450166812584 6.17412499492113e-05 36 3890 True False 0 0 0 0 0 0 0 0 0 0.327450166812584 0 0 0.000320664925697395 0.998945459147087 0.998443680572118 0.999317444144018 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Met666Ile rpoB_p.Met666Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Met707Thr rpoB_p.Met707Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Met920Val rpoB_p.Met920Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 12 0 16798 30532 0.000713860797144556 0.000368914962606047 0.00124663876852724 1 0.999879187193184 1 1 0.735351530602948 1 NA NA NA NA NA NA NA NA NA NA 2702 4649 False False Inf 5.04894728912605 Inf 0 0 0.000219578190293692 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 10 0 11492 23707 0.000869414014953921 0.000416994043678715 0.001598300185227 1 0.999844409142079 1 1 0.691502892181239 1 NA NA NA NA NA NA NA NA NA NA 2251 3890 False False 0 0 0 0 0 0 0 Inf 4.62268854495848 Inf 0 0 0.000320943914091465 1 0.999844409142079 1 3 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Met97_Ser98dup rpoB_p.Met97_Ser98dup 1 inframe_insertion (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2385 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1979 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Phe1005Val rpoB_p.Phe1005Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 6 2 16804 30530 0.000356930398572278 0.000130998068917797 0.000776724091447791 0.999934494956111 0.999763393503742 0.99999206693684 0.75 0.349144205587175 0.968145973750055 0 0 0.975 0 0 0.841886116991581 0 0 70.781403754524 1 1627.5 4649 False False 5.4504879790526 0.974471458740784 55.1804345522996 0 0 0.000219499796783869 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 6 1 11496 23706 0.000521648408972352 0.000191459062774625 0.00113506056981396 0.999957818365883 0.999765001636458 0.999998932054057 0.857142857142857 0.421276802956804 0.996389703138099 0 0 0.975 0 0 0.975 0 0 80.3259397723806 1 1214.5 3890 False False 0 0 0 0 0 0 0 12.3726513569937 1.50072525153826 567.507166587209 0 0 0.000320832260499258 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Phe151Leu rpoB_p.Phe151Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2471 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2057 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Phe208Leu rpoB_p.Phe208Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 0 9 0 9 16810 30523 0 0 0.000219421459229958 0.999705227302502 0.999440503684993 0.999865202576615 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.920078094923294 0.0314975203720328 131 4649 False False 0 0 0.920078094923294 0 0 0.000219421459229958 0.999705227302502 0.999440503684993 0.999865202576615 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 0 9 11502 23698 0 0 0.000320664925697395 0.999620365292951 0.999279457952852 0.99982639261309 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.336267116879942 0 0 1.04405446176545 0.0357327658391664 101.5 3890 False False 0 0 0 0 0 0 0 0 0 1.04405446176545 0 0 0.000320664925697395 0.999620365292951 0.999279457952852 0.99982639261309 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Phe295Leu rpoB_p.Phe295Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 1 6 16809 30526 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999803484868334 0.999572318737888 0.999927879105266 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.54260585225547 0.0957834295462749 205.5 4649 False False 0.302675154183274 0.00658396461982027 2.49513982006856 0 0 0.000219434511605659 0.999803484868334 0.999572318737888 0.999927879105266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 1 6 11501 23701 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.9997469101953 0.999449212060655 0.99990711502044 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.75053841604795 0.18683809940591 207.5 3890 False False 0 0 0 0 0 0 0 0.343462887285163 0.00747035147172492 2.83150389371471 0 0 0.000320692802708327 0.9997469101953 0.999449212060655 0.99990711502044 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Phe424Ile rpoB_p.Phe424Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2517 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Phe424Leu rpoB_p.Phe424Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 8 5 16802 30527 0.000475907198096371 0.00020548462525215 0.000937510381255989 0.999836237390279 0.999617874429585 0.999946824656822 0.615384615384615 0.315777602914063 0.861420661109839 0 0 0.975 0 0 0.521823750104981 0 0 70.7828716197489 1 1627.5 4649 False False 2.90698726342102 0.838334102961652 11.2954727017352 0 0 0.000219525921733526 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 4 11498 23703 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 0.999831273463534 0.999568049920357 0.99995402584539 0.5 0.157012770487058 0.842987229512941 NA NA NA 0 0 0.602364635616474 NA NA NA NA 2136 3890 False False 0 0 0 0 0 0 0 2.0614889546008 0.383888088909897 11.0704740677885 0 0 0.000320776462830572 0.999831273463534 0.999568049920357 0.99995402584539 5 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Phe424Val rpoB_p.Phe424Val 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 1 0 18 0 16792 30532 0.00107079119571683 0.000634738299600123 0.00169178580899694 1 0.999879187193184 1 1 0.814698031862147 1 1 0.025 1 1 0.025 1 Inf 0.0466187457545844 Inf 0.354844162704701 382 4649 False False Inf 7.99147236998928 Inf 5.95486214494134e-05 1.50763942709595e-06 0.000331738525086126 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 14 0 11488 23707 0.00121717962093548 0.000665598145642159 0.00204137811638842 1 0.999844409142079 1 1 0.768364238349883 1 NA NA NA NA NA NA NA NA NA NA 2214 3890 False False 0 0 0 0 0 0 0 Inf 6.84328477771802 Inf 0 0 0.000321055645424387 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Phe425_Gly426del rpoB_p.Phe425_Gly426del 1 inframe_deletion (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2429 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2020 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA RRDR RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Phe433_Asp435del rpoB_p.Phe433_Asp435del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 3 3 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.750576632084797 Inf 0.0447623983612152 140 4649 False False Inf 0.750576632084797 Inf 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.387090251295738 Inf 0.10671216244731 152.5 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 NA RRDR Marker of R RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Phe433_Gln436del rpoB_p.Phe433_Gln436del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 1 0 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0465728448998709 Inf 0.355069708491761 394 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 5.94919388422868e-05 1.50620434989522e-06 0.000331422795737767 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2137 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 2 RRDR RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Phe433dup rpoB_p.Phe433dup 1 inframe_insertion (see "Genomic_coordinates" sheet) 1 24 24 0 26 0 16784 30532 0.0015466983938132 0.00101059577405045 0.00226545603351431 1 0.999879187193184 1 1 0.867725395502245 1 1 0.857526402277474 1 1 0.857526402277474 1 Inf 10.9469444363805 Inf 1.59332554442547e-11 19 4649 True False Inf 11.9323359519505 Inf 0.0014278914802475 0.000915084579869834 0.0021238491622435 1 0.999879187193184 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 16 16 0 17 0 11485 23707 0.00147800382542166 0.000861220016155565 0.00236537605429428 1 0.999844409142079 1 1 0.804935677030906 1 1 0.794092785792177 1 1 0.794092785792177 1 Inf 7.95683041409628 Inf 1.66899480560008e-08 20 3890 True False 0 0 0 0 0 0 0 Inf 8.51620393516598 Inf 0.00139118337535866 0.000795384004583865 0.00225821410587643 1 0.999844409142079 1 3 RRDR 1) Assoc w R UP from AwRI to AwR yes 4 +Rifampicin rpoB p.Phe503Ser rpoB_p.Phe503Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 31 0 16779 30532 0.00184414039262343 0.00125333722248032 0.00261659758042388 1 0.999879187193184 1 1 0.88781125307763 1 1 0.025 1 1 0.025 1 Inf 0.0466548630898177 Inf 0.354666892120392 380 4649 False False Inf 14.3908106225041 Inf 5.95947556615017e-05 1.50880744245748e-06 0.000331995498468874 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 23 0 11479 23707 0.00199965223439401 0.00126801715451488 0.0029989585229059 1 0.999844409142079 1 1 0.851814871084775 1 1 0.025 1 1 0.025 1 Inf 0.0529503393646194 Inf 0.32625685622531 305 3890 False False 0 0 0 0 0 0 0 Inf 11.8681858649791 Inf 8.71080139372822e-05 2.20538153889951e-06 0.000485238164526316 1 0.999844409142079 1 11 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Phe503Val rpoB_p.Phe503Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2331 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1929 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Phe548Leu rpoB_p.Phe548Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Phe590Cys rpoB_p.Phe590Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Phe669Leu rpoB_p.Phe669Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Phe93Leu rpoB_p.Phe93Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Phe971Leu rpoB_p.Phe971Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 9 0 16801 30532 0.000535395597858417 0.000244845253515427 0.00101610321951737 1 0.999879187193184 1 1 0.663732883120057 1 NA NA NA NA NA NA NA NA NA NA 2368 4649 False False Inf 3.58631764003717 Inf 0 0 0.000219538986540545 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 6 0 11496 23707 0.000521648408972352 0.000191459062774625 0.00113506056981396 1 0.999844409142079 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 1965 3890 False False 0 0 0 0 0 0 0 Inf 2.42738974088595 Inf 0 0 0.000320832260499258 1 0.999844409142079 1 8 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Pro1014Arg rpoB_p.Pro1014Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 1 8 1 8 16809 30524 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999737979824446 0.999483781433772 0.999886871715824 0.111111111111111 0.00280913674659921 0.482496514917337 0.111111111111111 0.00280913674659921 0.482496514917337 0.111111111111111 0.00280913674659921 0.482496514917337 0.226991492652745 0.00511932236302294 1.69341645046941 0.172268372449239 283 4649 False False 0.226991492652745 0.00511932236302294 1.69341645046941 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999737979824446 0.999483781433772 0.999886871715824 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 1 8 1 8 11501 23699 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999662546927068 0.999335191784523 0.999854300817065 0.111111111111111 0.00280913674659921 0.482496514917337 0.111111111111111 0.00280913674659921 0.482496514917337 0.111111111111111 0.00280913674659921 0.482496514917337 0.257575428223632 0.00580827991067691 1.92165917942206 0.287414399377439 227 3890 False False 0 0 0 0 0 0 0 0.257575428223632 0.00580827991067691 1.92165917942206 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999662546927068 0.999335191784523 0.999854300817065 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Pro1014Gln rpoB_p.Pro1014Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Pro1014Ser rpoB_p.Pro1014Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2472 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2058 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Pro13Leu rpoB_p.Pro13Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Pro15_Ser16insSerPro rpoB_p.Pro15_Ser16insSerPro 1 inframe_insertion (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.9820231071276 0.168448731581911 252 4649 False False 0 0 1.9820231071276 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12235036001139 0.310791984491028 261 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Pro27His rpoB_p.Pro27His 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 2 5 16808 30527 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999836237390279 0.999617874429585 0.999946824656822 0.285714285714285 0.0366925661760855 0.709579136262657 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.98225896975909 0.168456568596501 274 4649 False False 0.726487386958591 0.069161301215026 4.43811993507661 0 0 0.000219447565534303 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 2 4 11500 23703 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999831273463534 0.999568049920357 0.99995402584539 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12289352368013 0.310805712195535 291 3890 False False 0 0 0 0 0 0 0 1.0305652173913 0.0931903474189042 7.19201282268065 0 0 0.000320720684566658 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Pro280Leu rpoB_p.Pro280Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 9 1 16801 30531 0.000535395597858417 0.000244845253515427 0.00101610321951737 0.999967247478055 0.999817528289014 0.999999170778282 0.9 0.554983882971804 0.997471421455538 NA NA NA 0 0 0.975 NA NA NA NA 2332 4649 False False 16.3549193500386 2.26573473572457 714.408215312578 0 0 0.000219538986540545 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 5 1 11497 23706 0.00043470700747696 0.000141162766530747 0.00101416710312943 0.999957818365883 0.999765001636458 0.999998932054057 0.833333333333333 0.358765421002325 0.99578925548551 NA NA NA 0 0 0.975 NA NA NA NA 1930 3890 False False 0 0 0 0 0 0 0 10.3096459946072 1.15337945963023 486.419600220716 0 0 0.000320804359238686 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Pro280Ser rpoB_p.Pro280Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2632 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2190 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Pro30Ala rpoB_p.Pro30Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 2 4 16808 30528 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999868989912223 0.999664596427238 0.999964303043777 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.75175148703504 0.304358946073845 356.5 4649 False False 0.90813898143741 0.0821237468238322 6.33854635470206 0 0 0.000219447565534303 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 2 4 11500 23703 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999831273463534 0.999568049920357 0.99995402584539 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12289352368013 0.310805712195535 291 3890 False False 0 0 0 0 0 0 0 1.0305652173913 0.0931903474189042 7.19201282268065 0 0 0.000320720684566658 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Pro30Ser rpoB_p.Pro30Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Pro321Ser rpoB_p.Pro321Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Pro358Leu rpoB_p.Pro358Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 16 0 16 3 18 16807 30514 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999410454605004 0.999068423526975 0.999650561796013 0.142857142857142 0.0304889676215155 0.363423987016981 0 0 0.205907214207822 0 0 0.185301968137852 0 0 0.470876121446496 0.00113564857982548 73 4649 False False 0.302592173895797 0.0570930355428442 1.03674460439863 0 0 0.000219460621016169 0.999410454605004 0.999068423526975 0.999650561796013 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 13 0 13 3 14 11499 23693 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.999409457122369 0.999009367705732 0.999677108302285 0.176470588235294 0.0379850680706259 0.434317872844283 0 0 0.24705263800047 0 0 0.231635761650116 0 0 0.676216608468705 0.0072229996170232 72 3890 False False 0 0 0 0 0 0 0 0.441522865342327 0.0813397116049465 1.58244684206396 0 0 0.000320748571273651 0.999409457122369 0.999009367705732 0.999677108302285 8 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Pro439Ala rpoB_p.Pro439Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2500 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA RRDR RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Pro439Leu rpoB_p.Pro439Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Pro439Ser rpoB_p.Pro439Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2586 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2150 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Pro454Arg rpoB_p.Pro454Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2430 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2021 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Pro454His rpoB_p.Pro454His 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 2 2 16808 30530 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999934494956111 0.999763393503742 0.99999206693684 0.5 0.067585986488543 0.932414013511457 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.67174719181657 0.54201215115422 740.5 4649 False False 1.8163969538315 0.131636449523742 25.0652602654423 0 0 0.000219447565534303 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1953 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 1 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Pro454Leu rpoB_p.Pro454Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 5 9 16805 30523 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 0.999705227302502 0.999440503684993 0.999865202576615 0.357142857142857 0.127598429859159 0.648619889384008 0 0 0.4592581264399 0 0 0.336267116879942 0 0 1.54282142423847 0.0957950128376074 209.5 4649 False False 1.00905815068266 0.265595742451005 3.35339436934209 0 0 0.000219486736640675 0.999705227302502 0.999440503684993 0.999865202576615 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 1 7 11501 23700 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999704728561184 0.999391723222185 0.999881277590374 0.125 0.0031597235312519 0.526509670875206 0 0 0.521823750104981 0 0 0.409616397225003 0 0 2.24913291205708 0.180425284179234 186 3890 False False 0 0 0 0 0 0 0 0.294384339250003 0.00653526389697788 2.29204336611244 0 0 0.000320692802708327 0.999704728561184 0.999391723222185 0.999881277590374 1 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Pro454Ser rpoB_p.Pro454Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2754 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2298 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Pro45Ala rpoB_p.Pro45Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 7 1 16803 30531 0.000416418798334324 0.000167437820935922 0.000857792460925722 0.999967247478055 0.999817528289014 0.999999170778282 0.875 0.473490329124793 0.996840276468748 NA NA NA 0 0 0.975 NA NA NA NA 2587 4649 False False 12.7189787537939 1.63372483035451 571.646572779703 0 0 0.000219512858481393 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 6 0 11496 23707 0.000521648408972352 0.000191459062774625 0.00113506056981396 1 0.999844409142079 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 2151 3890 False False 0 0 0 0 0 0 0 Inf 2.42738974088595 Inf 0 0 0.000320832260499258 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Pro45Arg rpoB_p.Pro45Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 11 0 16799 30532 0.00065437239738251 0.000326704163498642 0.00117055062018267 1 0.999879187193184 1 1 0.715085847081845 1 NA NA NA NA NA NA NA NA NA NA 2616 4649 False False Inf 4.56066720991606 Inf 0 0 0.000219565120820351 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 5 0 11497 23707 0.00043470700747696 0.000141162766530747 0.00101416710312943 1 0.999844409142079 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 2177 3890 False False 0 0 0 0 0 0 0 Inf 1.88913119689894 Inf 0 0 0.000320804359238686 1 0.999844409142079 1 1 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Pro45Gln rpoB_p.Pro45Gln 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2755 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2299 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Pro45Leu rpoB_p.Pro45Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 26 0 16784 30532 0.0015466983938132 0.00101059577405045 0.00226545603351431 1 0.999879187193184 1 1 0.867725395502245 1 NA NA NA NA NA NA NA NA NA NA 2633 4649 False False Inf 11.9323359519505 Inf 0 0 0.000219761326426665 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 17 0 11485 23707 0.00147800382542166 0.000861220016155565 0.00236537605429428 1 0.999844409142079 1 1 0.804935677030906 1 NA NA NA NA NA NA NA NA NA NA 2191 3890 False False 0 0 0 0 0 0 0 Inf 8.51620393516598 Inf 0 0 0.000321139494990277 1 0.999844409142079 1 9 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Pro45Ser rpoB_p.Pro45Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 65 1 16745 30531 0.00386674598453301 0.00298550248723015 0.00492586728145316 0.999967247478055 0.999817528289014 0.999999170778282 0.984848484848484 0.918447678905176 0.999616470415004 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0467480577488442 Inf 0.354210292531252 374 4649 False False 118.513884741713 20.5194990275587 4624.8036738299 5.97157530156455e-05 1.51187082560954e-06 0.000332669468741939 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 41 0 11461 23707 0.00356459746131107 0.00255919435806085 0.00483270406615093 1 0.999844409142079 1 1 0.913956163705971 1 1 0.025 1 1 0.025 1 Inf 0.0530334934730866 Inf 0.325912024794563 303 3890 False False 0 0 0 0 0 0 0 Inf 21.965266136217 Inf 8.72448089338684e-05 2.20884488071229e-06 0.000486000033761005 1 0.999844409142079 1 5 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Pro45Thr rpoB_p.Pro45Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 7 0 16803 30532 0.000416418798334324 0.000167437820935922 0.000857792460925722 1 0.999879187193184 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 2570 4649 False False Inf 2.61832748907777 Inf 0 0 0.000219512858481393 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 6 0 11496 23707 0.000521648408972352 0.000191459062774625 0.00113506056981396 1 0.999844409142079 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 2138 3890 False False 0 0 0 0 0 0 0 Inf 2.42738974088595 Inf 0 0 0.000320832260499258 1 0.999844409142079 1 1 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Pro479Ser rpoB_p.Pro479Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2646 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2202 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 5 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Pro483Leu rpoB_p.Pro483Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.81645644930985 0.0231390176049956 142.434189869949 1 1627.5 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 5.94919388422868e-05 1.50620434989522e-06 0.000331422795737767 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 2.06121206851578 0.0262561678399451 161.601678830082 0.54664351365823 365.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Pro483Ser rpoB_p.Pro483Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2355 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1954 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 1 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Pro483Thr rpoB_p.Pro483Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2782 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Pro502Leu rpoB_p.Pro502Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Pro509Ser rpoB_p.Pro509Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 1 16807 30531 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999967247478055 0.999817528289014 0.999999170778282 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 70.771098821806 1 1627.5 4649 False False 5.44969358005592 0.437509494081317 285.652299683162 0 0 0.000219460621016169 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 1 11499 23706 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.999957818365883 0.999765001636458 0.999998932054057 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 80.3050096524922 1 1214.5 3890 False False 0 0 0 0 0 0 0 6.18471171406209 0.496496186771195 324.103527365594 0 0 0.000320748571273651 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Pro541Leu rpoB_p.Pro541Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Pro577Ala rpoB_p.Pro577Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2386 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1980 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 1 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Pro577Leu rpoB_p.Pro577Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2537 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2108 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Pro577Thr rpoB_p.Pro577Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2647 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2203 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Pro618Ala rpoB_p.Pro618Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2648 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2204 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Pro682Ala rpoB_p.Pro682Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Pro682Thr rpoB_p.Pro682Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Pro700Arg rpoB_p.Pro700Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2617 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2178 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Pro700Leu rpoB_p.Pro700Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 70.7668929171829 1 1627.5 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 0 0 0.000219447565534303 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Pro700Ser rpoB_p.Pro700Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0465715996825058 Inf 0.355075831185839 416 4649 False False Inf 0.0465715996825058 Inf 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0528490600080728 Inf 0.32667783805277 340.5 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Pro719Ser rpoB_p.Pro719Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Pro768Leu rpoB_p.Pro768Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2571 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2139 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Pro834Leu rpoB_p.Pro834Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2756 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2300 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Pro834Thr rpoB_p.Pro834Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2414 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Pro856Leu rpoB_p.Pro856Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2282 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Pro89Ser rpoB_p.Pro89Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Pro906Gln rpoB_p.Pro906Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0465715996825058 Inf 0.355075831185839 416 4649 False False Inf 0.0465715996825058 Inf 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0528490600080728 Inf 0.32667783805277 340.5 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Pro906Leu rpoB_p.Pro906Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Pro954Arg rpoB_p.Pro954Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Pro969Ser rpoB_p.Pro969Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2431 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2022 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Pro988Ala rpoB_p.Pro988Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Pro988Ser rpoB_p.Pro988Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ser1009Thr rpoB_p.Ser1009Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ser1124Ala rpoB_p.Ser1124Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 1 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ser1133Ala rpoB_p.Ser1133Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2415 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2008 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Ser1134Arg rpoB_p.Ser1134Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ser1134Asn rpoB_p.Ser1134Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Ser1134Lys rpoB_p.Ser1134Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2416 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2009 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Ser16Cys rpoB_p.Ser16Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 16 0 16 0 16 16810 30516 0 0 0.000219421459229958 0.999475959648893 0.999149130429312 0.999700436936355 0 0 0.205907214207822 0 0 0.205907214207822 0 0 0.205907214207822 0 0 0.470822433885205 0.00113527686615248 71 4649 False False 0 0 0.470822433885205 0 0 0.000219421459229958 0.999475959648893 0.999149130429312 0.999700436936355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 13 0 13 0 13 11502 23694 0 0 0.000320664925697395 0.999451638756485 0.999062468123692 0.999707989454911 0 0 0.24705263800047 0 0 0.24705263800047 0 0 0.24705263800047 0 0 0.676068752178923 0.00721934906404229 70 3890 False False 0 0 0 0 0 0 0 0 0 0.676068752178923 0 0 0.000320664925697395 0.999451638756485 0.999062468123692 0.999707989454911 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ser176Leu rpoB_p.Ser176Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2487 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Ser195Arg rpoB_p.Ser195Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 80.2910622977969 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ser201Gly rpoB_p.Ser201Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2369 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1966 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Ser20Ile rpoB_p.Ser20Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 1 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ser21Phe rpoB_p.Ser21Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ser239Arg rpoB_p.Ser239Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ser239Asn rpoB_p.Ser239Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2333 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1931 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Ser249Ala rpoB_p.Ser249Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Ser254Pro rpoB_p.Ser254Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 4 2 16806 30530 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999934494956111 0.999763393503742 0.99999206693684 0.666666666666666 0.222778095503512 0.956728131707258 0 0 0.975 0 0 0.841886116991581 0 0 70.7729897200484 1 1627.5 4649 False False 3.63322622872783 0.520625747830046 40.1764939558657 0 0 0.000219473678051534 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 2 11500 23705 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999915636731767 0.999695284447545 0.999989783053538 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 80.2946525166223 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06130434782608 0.149383229063395 28.4413197127326 0 0 0.000320720684566658 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ser388Leu rpoB_p.Ser388Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 5 64 16805 30468 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 0.997903838595572 0.997324025972256 0.998385337547503 0.072463768115942 0.0239466209687045 0.161061740273612 0 0 0.975 0 0 0.0560090893866365 0 0 70.6336262419371 1 NA NA False True 0.141643112168997 0.0444758013258658 0.348183711215181 0 0 0.000219486736640675 0.997903838595572 0.997324025972256 0.998385337547503 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 1 0 1 4 56 11498 23651 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 0.997637828489475 0.996933605923382 0.998215162770186 0.0666666666666666 0.0184617775758815 0.161986755197728 0 0 0.975 0 0 0.0637500966623622 0 0 80.1258954248572 1 NA NA False True 0 1 1 0 0 1 1 0.146926173496011 0.0386816694637415 0.397768093949757 0 0 0.000320776462830572 0.997637828489475 0.996933605923382 0.998215162770186 1 Not assoc w R 5) Not assoc w R No change yes 1 +Rifampicin rpoB p.Ser428Arg rpoB_p.Ser428Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 7 1 16803 30531 0.000416418798334324 0.000167437820935922 0.000857792460925722 0.999967247478055 0.999817528289014 0.999999170778282 0.875 0.473490329124793 0.996840276468748 NA NA NA 0 0 0.975 NA NA NA NA 2554 4649 False False 12.7189787537939 1.63372483035451 571.646572779703 0 0 0.000219512858481393 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 1 11498 23706 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 0.999957818365883 0.999765001636458 0.999998932054057 0.8 0.28358206388191 0.994949236620532 NA NA NA 0 0 0.975 NA NA NA NA 2123 3890 False False 0 0 0 0 0 0 0 8.24699947817011 0.815939832795188 405.284913246419 0 0 0.000320776462830572 0.999957818365883 0.999765001636458 0.999998932054057 4 RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Ser428Gly rpoB_p.Ser428Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 1 16806 30531 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999967247478055 0.999817528289014 0.999999170778282 0.8 0.28358206388191 0.994949236620532 NA NA NA 0 0 0.975 NA NA NA NA 2459 4649 False False 7.26669046769011 0.71899465830523 357.208630433948 0 0 0.000219473678051534 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2046 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Ser428Ile rpoB_p.Ser428Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 1 16807 30531 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999967247478055 0.999817528289014 0.999999170778282 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 2600 4649 False False 5.44969358005592 0.437509494081317 285.652299683162 0 0 0.000219460621016169 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 2162 3890 False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 0 0 0.000320720684566658 0.999957818365883 0.999765001636458 0.999998932054057 NA RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Ser428Thr rpoB_p.Ser428Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 5 0 16805 30532 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 1 0.999879187193184 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 2555 4649 False False Inf 1.66460481015123 Inf 0 0 0.000219486736640675 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 5 0 11497 23707 0.00043470700747696 0.000141162766530747 0.00101416710312943 1 0.999844409142079 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 2124 3890 False False 0 0 0 0 0 0 0 Inf 1.88913119689894 Inf 0 0 0.000320804359238686 1 0.999844409142079 1 NA RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Ser431_Gln432insArg rpoB_p.Ser431_Gln432insArg 1 inframe_insertion (see "Genomic_coordinates" sheet) 1 3 3 0 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.750621306962686 Inf 0.0447572460384271 138 4649 False False Inf 1.1990579265185 Inf 0.00017847581652686 3.68075165264409e-05 0.000521492600944578 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.387090251295738 Inf 0.10671216244731 152.5 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 RRDR RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Ser431_Gln432insHis rpoB_p.Ser431_Gln432insHis 1 inframe_insertion (see "Genomic_coordinates" sheet) 1 4 4 0 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 1.1990579265185 Inf 0.0158922163386836 112.5 4649 False False Inf 1.1990579265185 Inf 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 4 0 4 0 11498 23707 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 1 0.999844409142079 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 1.3608069907404 Inf 0.0113848189908768 78.5 3890 False False 0 0 0 0 0 0 0 Inf 1.3608069907404 Inf 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 1 0.999844409142079 1 NA RRDR RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Ser431_Met434del rpoB_p.Ser431_Met434del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0465715996825058 Inf 0.355075831185839 416 4649 False False Inf 0.0465715996825058 Inf 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 RRDR RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Ser431Arg rpoB_p.Ser431Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 6 0 16804 30532 0.000356930398572278 0.000130998068917797 0.000776724091447791 1 0.999879187193184 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 2703 4649 False False Inf 2.13890645017026 Inf 0 0 0.000219499796783869 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 6 0 11496 23707 0.000521648408972352 0.000191459062774625 0.00113506056981396 1 0.999844409142079 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 2252 3890 False False 0 0 0 0 0 0 0 Inf 2.42738974088595 Inf 0 0 0.000320832260499258 1 0.999844409142079 1 NA RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Ser431Asn rpoB_p.Ser431Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2601 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2163 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 NA RRDR RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Ser431Gly rpoB_p.Ser431Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 10 1 16800 30531 0.000594883997620464 0.000285305684944214 0.00109373983334496 0.999967247478055 0.999817528289014 0.999999170778282 0.909090909090909 0.587220083011617 0.997701027786185 0 0 0.975 0 0 0.975 0 0 70.8005541583397 1 1627.5 4649 False False 18.1732142857142 2.58478875004711 785.727835535391 0 0 0.000219552052902727 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 9 1 11493 23706 0.000782472613458529 0.000357856744032263 0.00148485474620048 0.999957818365883 0.999765001636458 0.999998932054057 0.9 0.554983882971804 0.997471421455538 0 0 0.975 0 0 0.975 0 0 80.346880805265 1 1214.5 3890 False False 0 0 0 0 0 0 0 18.5638214565387 2.57162110235215 810.478378810226 0 0 0.000320915993408392 0.999957818365883 0.999765001636458 0.999998932054057 3 RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Ser431Thr rpoB_p.Ser431Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 2704 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 0 0 0.000219447565534303 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 2253 3890 False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 0 0 0.000320720684566658 0.999957818365883 0.999765001636458 0.999998932054057 NA RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Ser441Ala rpoB_p.Ser441Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 4 1 16806 30531 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999967247478055 0.999817528289014 0.999999170778282 0.8 0.28358206388191 0.994949236620532 0 0 0.975 0 0 0.975 0 0 70.7753052263996 1 1627.5 4649 False False 7.26669046769011 0.71899465830523 357.208630433948 0 0 0.000219473678051534 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1981 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 NA RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Ser441Gln rpoB_p.Ser441Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 32 30 2 30 2 16780 30530 0.00178465199286139 0.00120441111287972 0.00254672951354614 0.999934494956111 0.999763393503742 0.99999206693684 0.9375 0.791930570104992 0.992339263653543 0.9375 0.791930570104992 0.992339263653543 0.9375 0.791930570104992 0.992339263653543 27.2914183551847 6.92307272451557 234.450870191415 6.80475033517315e-12 18 4649 True False 27.2914183551847 6.92307272451557 234.450870191415 0.00178465199286139 0.00120441111287972 0.00254672951354614 0.999934494956111 0.999763393503742 0.99999206693684 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 31 29 2 29 2 11473 23705 0.00252130064336637 0.00168918484735422 0.00361901681244135 0.999915636731767 0.999695284447545 0.999989783053538 0.935483870967742 0.785783842836597 0.992089016538145 0.935483870967742 0.785783842836597 0.992089016538145 0.935483870967742 0.785783842836597 0.992089016538145 29.9592521572387 7.57767903800278 257.324958193223 1.72881571263538e-12 16 3890 True False 0 0 0 0 0 0 0 29.9592521572387 7.57767903800278 257.324958193223 0.00252130064336637 0.00168918484735422 0.00361901681244135 0.999915636731767 0.999695284447545 0.999989783053538 1 Assoc w R RRDR Assoc w R Marker of R 1) Assoc w R No change yes 1 +Rifampicin rpoB p.Ser441Leu rpoB_p.Ser441Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 18 17 1 38 1 16772 30531 0.00226055919095776 0.00160018760749268 0.00310148712776189 0.999967247478055 0.999817528289014 0.999999170778282 0.974358974358974 0.865236078440502 0.999351036104518 0.944444444444444 0.727056400326631 0.99859444383263 0.944444444444444 0.727056400326631 0.99859444383263 30.9460410207488 4.84807542252703 1285.34230975573 2.6633006562002e-07 29 4649 True False 69.1735034581445 11.6856769054776 2762.84825243579 0.00101256775269521 0.000589965174090101 0.00162072566581822 0.999967247478055 0.999817528289014 0.999999170778282 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 13 13 0 25 0 11477 23707 0.0021735350373848 0.00140707589428017 0.00320690572089761 1 0.999844409142079 1 1 0.862814828469287 1 1 0.752947361999529 1 1 0.752947361999529 1 Inf 6.29348366145385 Inf 4.75992617456018e-07 21 3890 True False 0 0 0 0 0 0 0 Inf 12.9870104436498 Inf 0.0011314186248912 0.000602565949490815 0.0019339831735039 1 0.999844409142079 1 3 Assoc w R RRDR Assoc w R Marker of R 1) Assoc w R No change yes 1 +Rifampicin rpoB p.Ser441Lys rpoB_p.Ser441Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA RRDR RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Ser441Met rpoB_p.Ser441Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 5 0 5 0 16805 30532 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 1 0.999879187193184 1 1 0.478176249895018 1 1 0.478176249895018 1 1 0.478176249895018 1 Inf 1.66460481015123 Inf 0.00564207587536264 89 4649 False False Inf 1.66460481015123 Inf 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 3 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.851788978516443 Inf 0.0348564168530142 96 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 NA RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Ser441Trp rpoB_p.Ser441Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0465715996825058 Inf 0.355075831185839 416 4649 False False Inf 0.0465715996825058 Inf 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA RRDR RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Ser441Val rpoB_p.Ser441Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 3 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.750576632084797 Inf 0.0447623983612152 140 4649 False False Inf 0.750576632084797 Inf 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.387090251295738 Inf 0.10671216244731 152.5 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 NA RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Ser450_Leu452del rpoB_p.Ser450_Leu452del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0465715996825058 Inf 0.355075831185839 416 4649 False False Inf 0.0465715996825058 Inf 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0528490600080728 Inf 0.32667783805277 340.5 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 NA RRDR Marker of R RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Ser450Ala rpoB_p.Ser450Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2460 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Ser450Cys rpoB_p.Ser450Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 2 4 3 5 16807 30527 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999836237390279 0.999617874429585 0.999946824656822 0.375 0.0852334141372535 0.755136783633448 0.333333333333333 0.0432718682927417 0.777221904496487 0.285714285714285 0.0366925661760855 0.709579136262657 0.908163265306122 0.0821259426795458 6.33871613747649 1 1627.5 4649 False False 1.08979591836734 0.169210020231233 5.60160594690905 0.000118983877684573 1.44098244078294e-05 0.000429743883731532 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 1 3 2 4 11500 23703 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999831273463534 0.999568049920357 0.99995402584539 0.333333333333333 0.0432718682927417 0.777221904496487 0.25 0.00630946320970987 0.805879550316756 0.2 0.00505076337946806 0.716417936118089 0.687043478260869 0.01309064337405 8.55811588658192 1 504 3890 False False 0 0 0 0 0 0 0 1.0305652173913 0.0931903474189042 7.19201282268065 8.69489609599165e-05 2.20135467503192e-06 0.000484352330576856 0.999831273463534 0.999568049920357 0.99995402584539 1 RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Ser450Gln rpoB_p.Ser450Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 9 0 12 0 16798 30532 0.000713860797144556 0.000368914962606047 0.00124663876852724 1 0.999879187193184 1 1 0.735351530602948 1 1 0.663732883120057 1 1 0.663732883120057 1 Inf 3.58695808346022 Inf 8.95034906264853e-05 50 4649 True False Inf 5.04894728912605 Inf 0.000535491164395787 0.000244888962724368 0.00101628454731894 1 0.999879187193184 1 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance 1 2 2 0 5 0 11497 23707 0.00043470700747696 0.000141162766530747 0.00101416710312943 1 0.999844409142079 1 1 0.478176249895018 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.387191276945091 Inf 0.106674679077367 148 3890 False False 0 0 0 0 0 0 0 Inf 1.88913119689894 Inf 0.000173928167666753 2.10642020967855e-05 0.000628145625606295 1 0.999844409142079 1 2 RRDR Assoc w RI Marker of R Evidence from ALL dataset only 2) Assoc w R - Interim No change yes ALL only 1 +Rifampicin rpoB p.Ser450Gly rpoB_p.Ser450Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 2 2 3 2 16807 30530 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999934494956111 0.999763393503742 0.99999206693684 0.6 0.146632799634673 0.947255049473683 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 1.81650502766704 0.131644282960758 25.0667488200294 0.618995337920762 927 4649 False False 2.72475754150056 0.312074221533576 32.6324551811023 0.000118983877684573 1.44098244078294e-05 0.000429743883731532 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 2 2 11500 23705 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999915636731767 0.999695284447545 0.999989783053538 0.5 0.067585986488543 0.932414013511457 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 1.03065217391304 0.0174732315977421 19.8074478808129 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06130434782608 0.149383229063395 28.4413197127326 8.69489609599165e-05 2.20135467503192e-06 0.000484352330576856 0.999915636731767 0.999695284447545 0.999989783053538 1 RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Ser450Leu rpoB_p.Ser450Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 8912 8722 190 10859 226 6002 30643 0.644030603167072 0.636749459170877 0.651262035029771 0.992678739188182 0.991663679631157 0.993599347513677 0.979612088407758 0.976806641628867 0.982161471974732 0.978680430879712 0.975464149129494 0.981578212008473 0.974742959320518 0.971277346463109 0.977894567964179 234.367707255476 201.586771825091 273.007673940479 0 1.5 4649 True False 245.310808639008 214.057996372405 282.118988462695 0.592366204835642 0.584377470741956 0.600318423799596 0.992678739188182 0.991663679631157 0.993599347513677 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 6009 5932 77 7443 96 4094 23768 0.64514171795094 0.636331761002516 0.653878381655403 0.995977204156889 0.995089664633228 0.996740343963261 0.987266215678472 0.984471814434079 0.989673752773909 0.987185887834914 0.984010246052956 0.989874431751417 0.984074319840743 0.980586362230069 0.98708160773243 447.255013672209 353.866090712715 565.208352202861 0 1 3890 True False 0 0 0 0 0 0 0 450.113031265266 369.841986455952 561.531483044593 0.591661679632954 0.581965085220083 0.601304996830076 0.995977204156889 0.995089664633228 0.996740343963261 2259 Assoc w R RRDR Assoc w R Marker of R 1) Assoc w R No change yes 1 +Rifampicin rpoB p.Ser450Met rpoB_p.Ser450Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 8 1 8 1 16802 30531 0.000475907198096371 0.00020548462525215 0.000937510381255989 0.999967247478055 0.999817528289014 0.999999170778282 0.888888888888888 0.517503485082663 0.9971908632534 0.888888888888888 0.517503485082663 0.9971908632534 0.888888888888888 0.517503485082663 0.9971908632534 14.5368408522794 1.94857414115003 643.047530935858 0.00155489723115019 74 4649 False False 14.5368408522794 1.94857414115003 643.047530935858 0.000475907198096371 0.00020548462525215 0.000937510381255989 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 3 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.851788978516443 Inf 0.0348564168530142 96 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 NA RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Ser450Phe rpoB_p.Ser450Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 195 195 0 206 1 16604 30531 0.0122546103509815 0.0106465043393595 0.0140346040838114 0.999967247478055 0.999817528289014 0.999999170778282 0.995169082125603 0.97337920029104 0.999877699228217 1 0.981260479169714 1 0.994897959183673 0.971902565304955 0.999870835852691 Inf 96.2257257639345 Inf 9.15280384703443e-89 5 4649 True False 378.787400626355 67.2207922887263 13542.7743597902 0.0116078337996309 0.0100433149009616 0.0133446883762804 0.999967247478055 0.999817528289014 0.999999170778282 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 170 170 0 173 0 11329 23707 0.0150408624587028 0.0128964223962606 0.0174355938687392 1 0.999844409142079 1 1 0.978902725349315 1 1 0.978534445019055 1 1 0.978534445019055 1 Inf 95.308650327421 Inf 1.04626561459335e-83 5 3890 True False 0 0 0 0 0 0 0 Inf 97.0402148881244 Inf 0.014783894251674 0.0126580546583208 0.0171602766289846 1 0.999844409142079 1 18 Assoc w R RRDR Assoc w R Marker of R 1) Assoc w R No change yes 1 +Rifampicin rpoB p.Ser450Trp rpoB_p.Ser450Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 192 187 5 238 5 16572 30527 0.014158239143367 0.0124269750756415 0.0160604528017418 0.999836237390279 0.999617874429585 0.999946824656822 0.979423868312757 0.952638061557644 0.993286034635227 0.973958333333333 0.940276797504557 0.991491438485004 0.973958333333333 0.940276797504557 0.991491438485004 68.893905382573 28.9657564619819 215.156022378171 6.88086430991876e-77 6 4649 True False 87.6831523050929 37.0526677703276 271.946108877763 0.0111581836625096 0.00962331242024939 0.0128660451516936 0.999836237390279 0.999617874429585 0.999946824656822 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 149 146 3 194 3 11308 23704 0.016866631890106 0.01459273339424 0.0193895419803353 0.99987345509765 0.999630227076139 0.999973902638554 0.98477157360406 0.956143372552642 0.996848454529756 0.97986577181208 0.942288449533963 0.995828434749774 0.97986577181208 0.942288449533963 0.995828434749774 102.015800023582 34.2163972068191 499.508773325016 6.90836894659217e-67 6 3890 True False 0 0 0 0 0 0 0 135.555241127225 45.6536056400685 666.677769846407 0.0127466387288283 0.0107731721482364 0.0149731777317047 0.99987345509765 0.999630227076139 0.999973902638554 31 Assoc w R RRDR Assoc w R Marker of R 1) Assoc w R No change yes 1 +Rifampicin rpoB p.Ser450Tyr rpoB_p.Ser450Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 9 0 9 0 16801 30532 0.000535395597858417 0.000244845253515427 0.00101610321951737 1 0.999879187193184 1 1 0.663732883120057 1 1 0.663732883120057 1 1 0.663732883120057 1 Inf 3.58631764003717 Inf 8.95962936924637e-05 51.5 4649 True False Inf 3.58631764003717 Inf 0.000535395597858417 0.000244845253515427 0.00101610321951737 1 0.999879187193184 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 9 9 0 9 0 11493 23707 0.000782472613458529 0.000357856744032263 0.00148485474620048 1 0.999844409142079 1 1 0.663732883120057 1 1 0.663732883120057 1 1 0.663732883120057 1 Inf 4.07050547199104 Inf 4.22825832734201e-05 35 3890 True False 0 0 0 0 0 0 0 Inf 4.07050547199104 Inf 0.000782472613458529 0.000357856744032263 0.00148485474620048 1 0.999844409142079 1 3 RRDR Assoc w RI 1) Assoc w R UP from AwRI to AwR yes 4 +Rifampicin rpoB p.Ser450Val rpoB_p.Ser450Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 5 4 16805 30528 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 0.999868989912223 0.999664596427238 0.999964303043777 0.555555555555555 0.212008506778868 0.863004337734833 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.75224277947161 0.304362935828684 363 4649 False False 2.27075275215709 0.488655453172155 11.44624379658 0 0 0.000219486736640675 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 1 11499 23706 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.999957818365883 0.999765001636458 0.999998932054057 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 80.3050096524922 1 1214.5 3890 False False 0 0 0 0 0 0 0 6.18471171406209 0.496496186771195 324.103527365594 0 0 0.000320748571273651 0.999957818365883 0.999765001636458 0.999998932054057 1 RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Ser458Thr rpoB_p.Ser458Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2417 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2010 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Ser493Arg rpoB_p.Ser493Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 2 1 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 3.6329128986197 0.189104318453829 214.057761575796 0.28869722941154 292 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 2.06121206851578 0.0262561678399451 161.601678830082 0.54664351365823 365.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Ser493Leu rpoB_p.Ser493Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 17 0 16793 30532 0.00101130279595478 0.000589228022589122 0.0016187015795436 1 0.999879187193184 1 1 0.804935677030906 1 NA NA NA NA NA NA NA NA NA NA 2400 4649 False False Inf 7.50125453808733 Inf 0 0 0.000219643561005912 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 13 0 11489 23707 0.00113023821944009 0.000601937155487611 0.00193196626494298 1 0.999844409142079 1 1 0.752947361999529 1 NA NA NA NA NA NA NA NA NA NA 1994 3890 False False 0 0 0 0 0 0 0 Inf 6.28688570681876 Inf 0 0 0.000321027705298525 1 0.999844409142079 1 1 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ser493Pro rpoB_p.Ser493Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2618 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2179 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 2 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Ser493Thr rpoB_p.Ser493Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 2 16806 30530 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999934494956111 0.999763393503742 0.99999206693684 0.666666666666666 0.222778095503512 0.956728131707258 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2668 4649 False False 3.63322622872783 0.520625747830046 40.1764939558657 0 0 0.000219473678051534 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 2 11499 23705 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.999915636731767 0.999695284447545 0.999989783053538 0.6 0.146632799634673 0.947255049473683 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2219 3890 False False 0 0 0 0 0 0 0 3.09222541090529 0.354154889835857 37.0377673791385 0 0 0.000320748571273651 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Ser493Trp rpoB_p.Ser493Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.9820231071276 0.168448731581911 252 4649 False False 0 0 1.9820231071276 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ser495Pro rpoB_p.Ser495Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2669 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2220 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Ser540Pro rpoB_p.Ser540Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2334 4649 False False Inf 1.1990579265185 Inf 0 0 0.000219473678051534 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 0 11498 23707 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 1 0.999844409142079 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 1932 3890 False False 0 0 0 0 0 0 0 Inf 1.3608069907404 Inf 0 0 0.000320776462830572 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ser567Pro rpoB_p.Ser567Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2473 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2059 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ser576Leu rpoB_p.Ser576Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2588 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2152 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Ser582Ala rpoB_p.Ser582Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2670 4649 False False Inf 1.1990579265185 Inf 0 0 0.000219473678051534 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2221 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ser582Thr rpoB_p.Ser582Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2726 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2271 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ser641Arg rpoB_p.Ser641Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ser672Ala rpoB_p.Ser672Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2556 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2125 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Ser672Cys rpoB_p.Ser672Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2387 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1982 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 2 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Ser672Phe rpoB_p.Ser672Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 4 2 16806 30530 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999934494956111 0.999763393503742 0.99999206693684 0.666666666666666 0.222778095503512 0.956728131707258 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.67289635744665 0.542027951562172 754 4649 False False 3.63322622872783 0.520625747830046 40.1764939558657 0 0 0.000219473678051534 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2283 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ser672Pro rpoB_p.Ser672Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2770 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2311 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Ser672Tyr rpoB_p.Ser672Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2538 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Ser67Phe rpoB_p.Ser67Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ser874Thr rpoB_p.Ser874Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2356 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1955 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Ser874Tyr rpoB_p.Ser874Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 21 0 16789 30532 0.00124925639500297 0.000773470498752546 0.00190899053306069 1 0.999879187193184 1 1 0.83890238478092 1 NA NA NA NA NA NA NA NA NA NA 2446 4649 False False Inf 9.46741729237089 Inf 0 0 0.000219695885606983 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 7 0 11495 23707 0.000608589810467744 0.000244718560881119 0.00125352303681455 1 0.999844409142079 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 2034 3890 False False 0 0 0 0 0 0 0 Inf 2.97179240572548 Inf 0 0 0.000320860166613556 1 0.999844409142079 1 8 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ser88Pro rpoB_p.Ser88Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2461 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2047 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ser936Arg rpoB_p.Ser936Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.75142405620251 0.304356294847217 327.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12235036001139 0.310791984491028 261 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 1 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ser96Pro rpoB_p.Ser96Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2671 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2222 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Ser984Leu rpoB_p.Ser984Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Ser98Ala rpoB_p.Ser98Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Thr155Ile rpoB_p.Thr155Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2602 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2164 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Thr159Pro rpoB_p.Thr159Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 7 0 16803 30532 0.000416418798334324 0.000167437820935922 0.000857792460925722 1 0.999879187193184 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 2401 4649 False False Inf 2.61832748907777 Inf 0 0 0.000219512858481393 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 5 0 11497 23707 0.00043470700747696 0.000141162766530747 0.00101416710312943 1 0.999844409142079 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 1995 3890 False False 0 0 0 0 0 0 0 Inf 1.88913119689894 Inf 0 0 0.000320804359238686 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Thr184Ser rpoB_p.Thr184Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2705 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2254 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Thr215Ala rpoB_p.Thr215Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Thr288Ala rpoB_p.Thr288Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2357 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1956 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Thr347Asn rpoB_p.Thr347Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Thr347Ile rpoB_p.Thr347Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Thr350Ile rpoB_p.Thr350Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 22 0 22 0 22 16810 30510 0 0 0.000219421459229958 0.999279444517227 0.998909272375137 0.999548378362908 0 0 0.154372512815574 0 0 0.154372512815574 0 0 0.154372512815574 0 0 0.331393813311992 7.5690313726327e-05 46 4649 True False 0 0 0.331393813311992 0 0 0.000219421459229958 0.999279444517227 0.998909272375137 0.999548378362908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 18 0 18 0 18 11502 23689 0 0 0.000320664925697395 0.999240730585902 0.998800291409329 0.999549948712402 0 0 0.185301968137852 0 0 0.185301968137852 0 0 0.185301968137852 0 0 0.468558999031164 0.00149074629511515 54 3890 False False 0 0 0 0 0 0 0 0 0 0.468558999031164 0 0 0.000320664925697395 0.999240730585902 0.998800291409329 0.999549948712402 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Thr350Pro rpoB_p.Thr350Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Thr361Val rpoB_p.Thr361Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2672 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2223 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Thr399Ala rpoB_p.Thr399Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2323 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1924 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 2 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Thr399Ile rpoB_p.Thr399Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 21 0 16789 30532 0.00124925639500297 0.000773470498752546 0.00190899053306069 1 0.999879187193184 1 1 0.83890238478092 1 NA NA NA NA NA NA NA NA NA NA 2649 4649 False False Inf 9.46741729237089 Inf 0 0 0.000219695885606983 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 15 0 11487 23707 0.00130412102243088 0.000730084557867185 0.00215003854003137 1 0.999844409142079 1 1 0.781980639089466 1 NA NA NA NA NA NA NA NA NA NA 2205 3890 False False 0 0 0 0 0 0 0 Inf 7.40065484717093 Inf 0 0 0.000321083590414119 1 0.999844409142079 1 3 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Thr399Pro rpoB_p.Thr399Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2418 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2011 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Thr400Ala rpoB_p.Thr400Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 39 0 16771 30532 0.0023200475907198 0.00165028486749537 0.00317023071319027 1 0.999879187193184 1 1 0.909748899039665 1 NA NA NA NA NA NA NA NA NA NA 2619 4649 False False Inf 18.3463480189943 Inf 0 0 0.000219931655152409 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 25 0 11477 23707 0.0021735350373848 0.00140707589428017 0.00320690572089761 1 0.999844409142079 1 1 0.862814828469287 1 NA NA NA NA NA NA NA NA NA NA 2180 3890 False False 0 0 0 0 0 0 0 Inf 12.9870104436498 Inf 0 0 0.000321363308103974 1 0.999844409142079 1 4 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Thr400Asn rpoB_p.Thr400Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 5 0 16805 30532 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 1 0.999879187193184 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 2727 4649 False False Inf 1.66460481015123 Inf 0 0 0.000219486736640675 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2272 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Thr400Ile rpoB_p.Thr400Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2447 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Thr400Pro rpoB_p.Thr400Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2370 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Thr400Ser rpoB_p.Thr400Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 8 0 16802 30532 0.000475907198096371 0.00020548462525215 0.000937510381255989 1 0.999879187193184 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 2687 4649 False False Inf 3.10133467016734 Inf 0 0 0.000219525921733526 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 7 0 11495 23707 0.000608589810467744 0.000244718560881119 0.00125352303681455 1 0.999844409142079 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 2236 3890 False False 0 0 0 0 0 0 0 Inf 2.97179240572548 Inf 0 0 0.000320860166613556 1 0.999844409142079 1 2 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Thr427_Gln429del rpoB_p.Thr427_Gln429del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0465715996825058 Inf 0.355075831185839 416 4649 False False Inf 0.0465715996825058 Inf 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0528490600080728 Inf 0.32667783805277 340.5 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 NA RRDR RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Thr427_Gln429delinsLys rpoB_p.Thr427_Gln429delinsLys 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0465715996825058 Inf 0.355075831185839 416 4649 False False Inf 0.0465715996825058 Inf 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0528490600080728 Inf 0.32667783805277 340.5 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 RRDR RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Thr427_Ser428del rpoB_p.Thr427_Ser428del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 5 4 1 4 1 16806 30531 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999967247478055 0.999817528289014 0.999999170778282 0.8 0.28358206388191 0.994949236620532 0.8 0.28358206388191 0.994949236620532 0.8 0.28358206388191 0.994949236620532 7.26669046769011 0.71899465830523 357.208630433948 0.0568927781919675 167 4649 False False 7.26669046769011 0.71899465830523 357.208630433948 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0528490600080728 Inf 0.32667783805277 340.5 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 2 RRDR RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Thr427Ala rpoB_p.Thr427Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 4 1 16806 30531 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999967247478055 0.999817528289014 0.999999170778282 0.8 0.28358206388191 0.994949236620532 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.81667261692252 0.023141771135672298 142.451120075049 1 1627.5 4649 False False 7.26669046769011 0.71899465830523 357.208630433948 5.94990182661986e-05 1.50638358512048e-06 0.000331462229036007 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 4 0 11498 23707 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 1 0.999844409142079 1 1 0.397635364383525 1 1 0.025 1 1 0.025 1 Inf 0.0528628480096367 Inf 0.326620462421178 313.5 3890 False False 0 0 0 0 0 0 0 Inf 1.3608069907404 Inf 8.69640838333768e-05 2.20173755219544e-06 0.00048443655634461 1 0.999844409142079 1 1 RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Thr427Asn rpoB_p.Thr427Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Thr427Gly rpoB_p.Thr427Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Thr427Ile rpoB_p.Thr427Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 5 0 16805 30532 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 1 0.999879187193184 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 2738 4649 False False Inf 1.66460481015123 Inf 0 0 0.000219486736640675 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 0 11498 23707 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 1 0.999844409142079 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2284 3890 False False 0 0 0 0 0 0 0 Inf 1.3608069907404 Inf 0 0 0.000320776462830572 1 0.999844409142079 1 NA RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Thr427Pro rpoB_p.Thr427Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2572 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 RRDR RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Thr427Ser rpoB_p.Thr427Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2739 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2285 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 1 RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Thr444dup rpoB_p.Thr444dup 1 inframe_insertion (see "Genomic_coordinates" sheet) 1 10 10 0 10 0 16800 30532 0.000594883997620464 0.000285305684944214 0.00109373983334496 1 0.999879187193184 1 1 0.691502892181239 1 1 0.691502892181239 1 1 0.691502892181239 1 Inf 4.07313735951873 Inf 3.18024915033292e-05 42 4649 True False Inf 4.07313735951873 Inf 0.000594883997620464 0.000285305684944214 0.00109373983334496 1 0.999879187193184 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 10 10 0 10 0 11492 23707 0.000869414014953921 0.000416994043678715 0.001598300185227 1 0.999844409142079 1 1 0.691502892181239 1 1 0.691502892181239 1 1 0.691502892181239 1 Inf 4.62268854495848 Inf 1.3805503680722e-05 31 3890 True False 0 0 0 0 0 0 0 Inf 4.62268854495848 Inf 0.000869414014953921 0.000416994043678715 0.001598300185227 1 0.999844409142079 1 NA RRDR 1) Assoc w R UP from AwRI to AwR yes 4 +Rifampicin rpoB p.Thr444Ile rpoB_p.Thr444Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2650 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2206 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Thr444Pro rpoB_p.Thr444Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2688 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2237 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 1 RRDR RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Thr444Ser rpoB_p.Thr444Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2783 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2323 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA RRDR Assoc w RI RRDR 2) Assoc w R - Interim No change yes RRDR 1 +Rifampicin rpoB p.Thr482Ala rpoB_p.Thr482Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2603 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2165 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Thr482Ile rpoB_p.Thr482Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2557 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2126 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Thr508Pro rpoB_p.Thr508Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2558 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Thr526Asn rpoB_p.Thr526Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Thr52Pro rpoB_p.Thr52Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 6 0 16804 30532 0.000356930398572278 0.000130998068917797 0.000776724091447791 1 0.999879187193184 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 2740 4649 False False Inf 2.13890645017026 Inf 0 0 0.000219499796783869 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2286 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 2 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Thr52Ser rpoB_p.Thr52Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Thr585Ala rpoB_p.Thr585Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2501 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2079 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Thr653Ala rpoB_p.Thr653Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.81634838479386 0.0231376410853604 142.42572627634 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 2.06121206851578 0.0262561678399451 161.601678830082 0.54664351365823 365.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Thr660Asn rpoB_p.Thr660Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Thr676Ala rpoB_p.Thr676Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2518 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Thr676Ile rpoB_p.Thr676Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2706 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Thr676Pro rpoB_p.Thr676Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 1 16807 30531 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999967247478055 0.999817528289014 0.999999170778282 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 2660 4649 False False 5.44969358005592 0.437509494081317 285.652299683162 0 0 0.000219460621016169 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2215 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Thr742Ala rpoB_p.Thr742Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2448 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Thr742Asn rpoB_p.Thr742Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2604 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2166 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Thr756Ala rpoB_p.Thr756Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2388 4649 False False Inf 1.1990579265185 Inf 0 0 0.000219473678051534 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1983 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Thr905Ile rpoB_p.Thr905Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Thr928Asn rpoB_p.Thr928Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2371 4649 False False Inf 1.1990579265185 Inf 0 0 0.000219473678051534 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1967 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 1 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Thr9Ile rpoB_p.Thr9Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Thr9Lys rpoB_p.Thr9Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2335 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1933 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Tyr308Asp rpoB_p.Tyr308Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 5 1 16805 30531 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 0.999967247478055 0.999817528289014 0.999999170778282 0.833333333333333 0.358765421002325 0.99578925548551 NA NA NA 0 0 0.975 NA NA NA NA 2689 4649 False False 9.08390360011901 1.01631102884943 428.726615606949 0 0 0.000219486736640675 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 1 11498 23706 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 0.999957818365883 0.999765001636458 0.999998932054057 0.8 0.28358206388191 0.994949236620532 NA NA NA 0 0 0.975 NA NA NA NA 2238 3890 False False 0 0 0 0 0 0 0 8.24699947817011 0.815939832795188 405.284913246419 0 0 0.000320776462830572 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Tyr308Cys rpoB_p.Tyr308Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 14 0 16796 30532 0.000832837596668649 0.000455392489979272 0.00139696554892221 1 0.999879187193184 1 1 0.768364238349883 1 NA NA NA NA NA NA NA NA NA NA 2784 4649 False False Inf 6.02871753174659 Inf 0 0 0.000219604333908644 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 11 0 11491 23707 0.000956355416449313 0.000477502787107626 0.00171053820723243 1 0.999844409142079 1 1 0.715085847081845 1 NA NA NA NA NA NA NA NA NA NA 2324 3890 False False 0 0 0 0 0 0 0 Inf 5.1761760609822 Inf 0 0 0.000320971839633333 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Tyr510His rpoB_p.Tyr510His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2589 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Tyr564Cys rpoB_p.Tyr564Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2673 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2224 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Tyr564His rpoB_p.Tyr564His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 15 0 16795 30532 0.000892325996430696 0.000499511372123772 0.00147132963433071 1 0.999879187193184 1 1 0.781980639089466 1 NA NA NA NA NA NA NA NA NA NA 2573 4649 False False Inf 6.51893136980533 Inf 0 0 0.00021961740805081 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 10 0 11492 23707 0.000869414014953921 0.000416994043678715 0.001598300185227 1 0.999844409142079 1 1 0.691502892181239 1 NA NA NA NA NA NA NA NA NA NA 2140 3890 False False 0 0 0 0 0 0 0 Inf 4.62268854495848 Inf 0 0 0.000320943914091465 1 0.999844409142079 1 3 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Tyr572Cys rpoB_p.Tyr572Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 1 4 16809 30528 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999868989912223 0.999664596427238 0.999964303043777 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.75158776187525 0.30435761959971 350.5 4649 False False 0.454042477244333 0.00922341562850508 4.58878013974823 0 0 0.000219434511605659 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 3 11501 23704 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.99987345509765 0.999630227076139 0.999973902638554 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98868218084989 0.555670981350655 466 3890 False False 0 0 0 0 0 0 0 0.687012723531287 0.0130900577164196 8.55773267307823 0 0 0.000320692802708327 0.99987345509765 0.999630227076139 0.999973902638554 1 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Tyr572His rpoB_p.Tyr572His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2432 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2023 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Tyr651His rpoB_p.Tyr651His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Tyr866His rpoB_p.Tyr866His 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2757 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2301 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Val1117Leu rpoB_p.Val1117Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Val113Ile rpoB_p.Val113Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 53 0 53 8 59 16802 30473 0.000475907198096371 0.00020548462525215 0.000937510381255989 0.998067601205292 0.997508044800699 0.998528653048731 0.119402985074626 0.052984805943161 0.221785138439942 0 0 0.0672345463063011 0 0 0.0606089009503398 0 0 0.130753665523795 1.68727774773423e-10 21 4649 True False 0.245919069360185 0.101447983193422 0.517073493603021 0 0 0.000219525921733526 0.998067601205292 0.997508044800699 0.998528653048731 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 27 0 27 4 31 11498 23676 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 0.998692369342388 0.998144431704435 0.999111360865311 0.114285714285714 0.032031169029098 0.267378043719245 0 0 0.127702867615432 0 0 0.11218874692237 0 0 0.301509742186169 3.5474089708651e-05 34 3890 True False 0 0 0 0 0 0 0 0.265695576790353 0.0681528871481428 0.751787653287781 0 0 0.000320776462830572 0.998692369342388 0.998144431704435 0.999111360865311 9 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Val1168Phe rpoB_p.Val1168Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Val129Gly rpoB_p.Val129Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Val129Ile rpoB_p.Val129Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Val168Ala rpoB_p.Val168Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 10 0 16800 30532 0.000594883997620464 0.000285305684944214 0.00109373983334496 1 0.999879187193184 1 1 0.691502892181239 1 NA NA NA NA NA NA NA NA NA NA 2519 4649 False False Inf 4.07313735951873 Inf 0 0 0.000219552052902727 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 9 0 11493 23707 0.000782472613458529 0.000357856744032263 0.00148485474620048 1 0.999844409142079 1 1 0.663732883120057 1 NA NA NA NA NA NA NA NA NA NA 2090 3890 False False 0 0 0 0 0 0 0 Inf 4.07050547199104 Inf 0 0 0.000320915993408392 1 0.999844409142079 1 2 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Val168Gly rpoB_p.Val168Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2620 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Val168Leu rpoB_p.Val168Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2502 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2080 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Val168Met rpoB_p.Val168Met 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2651 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Val170Ala rpoB_p.Val170Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 11 3 16799 30529 0.00065437239738251 0.000326704163498642 0.00117055062018267 0.999901742434167 0.999712876815577 0.99997973646933 0.785714285714285 0.492024322951528 0.953420712110132 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2559 4649 False False 6.6634720320654 1.75984687194931 37.2004360275228 0 0 0.000219565120820351 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 6 2 11496 23705 0.000521648408972352 0.000191459062774625 0.00113506056981396 0.999915636731767 0.999695284447545 0.999989783053538 0.75 0.349144205587175 0.968145973750055 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2127 3890 False False 0 0 0 0 0 0 0 6.18606471816283 1.10590335698881 62.723657220841 0 0 0.000320832260499258 0.999915636731767 0.999695284447545 0.999989783053538 2 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Val170Gly rpoB_p.Val170Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2462 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2048 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Val170Ile rpoB_p.Val170Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2741 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2287 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Val170Phe rpoB_p.Val170Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 41 40 1 89 2 16721 30530 0.00529446757882213 0.00425398574542891 0.00651131741998265 0.999934494956111 0.999763393503742 0.99999206693684 0.978021978021978 0.922854607245398 0.997327188573375 0.975609756097561 0.871445979615853 0.999382683106713 0.952380952380952 0.838358040308346 0.99418017516449 73.0339094551761 12.3722374455563 2910.64688678758 2.49055302607988e-17 15 4649 True False 81.2502242688834 21.8372285231465 682.451660123542 0.00238649245271761 0.00170547577511411 0.00324832234199439 0.999934494956111 0.999763393503742 0.99999206693684 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 29 28 1 62 1 11440 23706 0.00539036689271431 0.00413518674449234 0.00690495171947036 0.999957818365883 0.999765001636458 0.999998932054057 0.984126984126984 0.914704290700737 0.999598210770915 0.96551724137931 0.822355704511277 0.99912735311642 0.96551724137931 0.822355704511277 0.99912735311642 58.0216783216783 9.58664074719395 2344.15044643773 4.57083547502873e-13 15 3890 True False 0 0 0 0 0 0 0 128.476573426573 22.2147081980674 5002.79840890137 0.00244157656086501 0.00162300419170339 0.00352683931636791 0.999957818365883 0.999765001636458 0.999998932054057 18 Assoc w R Assoc w R 1) Assoc w R No change yes 1 +Rifampicin rpoB p.Val179Met rpoB_p.Val179Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Val196Ala rpoB_p.Val196Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2674 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2225 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Val198Met rpoB_p.Val198Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Val216Ile rpoB_p.Val216Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2433 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Val228Ile rpoB_p.Val228Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2389 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1984 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Val262Phe rpoB_p.Val262Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Val26Ala rpoB_p.Val26Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0465715996825058 Inf 0.355075831185839 416 4649 False False Inf 0.0465715996825058 Inf 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0528490600080728 Inf 0.32667783805277 340.5 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Val305Ile rpoB_p.Val305Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 5 0 16805 30532 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 1 0.999879187193184 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 2707 4649 False False Inf 1.66460481015123 Inf 0 0 0.000219486736640675 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2255 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Val305Leu rpoB_p.Val305Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2539 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2109 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Val310Gly rpoB_p.Val310Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Val332Ile rpoB_p.Val332Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Val33Leu rpoB_p.Val33Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Val351Ala rpoB_p.Val351Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2758 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2302 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Val351Ile rpoB_p.Val351Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Val355Ile rpoB_p.Val355Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2675 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Val357Leu rpoB_p.Val357Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2661 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Val359Ala rpoB_p.Val359Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 14 1 13 4 14 16806 30518 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999541464692781 0.999230775228684 0.999749292529582 0.222222222222222 0.0640920477176664 0.47637276573648 0.0714285714285714 0.00180678065912538 0.338684489931821 0.0666666666666666 0.0016864302413527 0.319484566578303 0.139684544896969 0.00329074707549315 0.930140174553422 0.0255242174217971 126 4649 False False 0.518828309617313 0.124335285817025 1.65240263371632 5.94990182661986e-05 1.50638358512048e-06 0.000331462229036007 0.999541464692781 0.999230775228684 0.999749292529582 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 0 11 1 12 11501 23695 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999493820390602 0.999115973206486 0.999738423129043 0.0769230769230769 0.00194562849734675 0.360297435267877 0 0 0.284914152918154 0 0 0.264648469397051 0 0 0.821060721051958 0.0205746989723521 91 3890 False False 0 0 0 0 0 0 0 0.171687969162101 0.00401993268933778 1.16069064496843 0 0 0.000320692802708327 0.999493820390602 0.999115973206486 0.999738423129043 6 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Val375Leu rpoB_p.Val375Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2434 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2024 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Val394Leu rpoB_p.Val394Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2390 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Val44Ala rpoB_p.Val44Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Val44Gly rpoB_p.Val44Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2690 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2239 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Val469Leu rpoB_p.Val469Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2605 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Val496Ala rpoB_p.Val496Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 43 1 16767 30531 0.00255800118976799 0.00185183780155513 0.00344408115441007 0.999967247478055 0.999817528289014 0.999999170778282 0.977272727272727 0.879758417793652 0.999424760786636 1 0.158113883008419 1 0.666666666666666 0.0942993240502461 0.991596241340387 Inf 0.341973967980244 Inf 0.125682650344551 220 4649 False False 78.2986222937913 13.3183946818308 3111.24421256311 0.000119267696344445 1.44441977157626e-05 0.000430768815299226 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 34 1 11468 23706 0.00295600765084333 0.0020479634181413 0.00412829743248029 0.999957818365883 0.999765001636458 0.999998932054057 0.971428571428571 0.850827920343568 0.999276895623662 1 0.158113883008419 1 0.666666666666666 0.0942993240502461 0.991596241340387 Inf 0.388154202327298 Inf 0.106318395028981 147 3890 False False 0 0 0 0 0 0 0 70.2828740844087 11.7903253929527 2814.41830989645 0.0001743679163034 2.111746121114e-05 0.000629733426331389 0.999957818365883 0.999765001636458 0.999998932054057 6 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Val496Glu rpoB_p.Val496Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2419 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2012 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Val496Gly rpoB_p.Val496Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2540 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2110 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Val496Leu rpoB_p.Val496Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2474 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2060 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 8 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Val496Met rpoB_p.Val496Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 22 0 16788 30532 0.00130874479476502 0.000820359439669085 0.00198078881845282 1 0.999879187193184 1 1 0.845627487184425 1 1 0.025 1 1 0.025 1 Inf 0.0466298528235292 Inf 0.354789628283426 381 4649 False False Inf 9.95930561201006 Inf 5.95628089820715e-05 1.50799862378195e-06 0.000331817551439048 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 13 0 11489 23707 0.00113023821944009 0.000601937155487611 0.00193196626494298 1 0.999844409142079 1 1 0.752947361999529 1 1 0.025 1 1 0.025 1 Inf 0.052904255214182 Inf 0.326448276841776 310.5 3890 False False 0 0 0 0 0 0 0 Inf 6.28688570681876 Inf 8.70322019147084e-05 2.20346214890025e-06 0.000484815935079836 1 0.999844409142079 1 8 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Val500_Asn501dup rpoB_p.Val500_Asn501dup 1 inframe_insertion (see "Genomic_coordinates" sheet) 0 0 0 0 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2742 4649 False False Inf 1.1990579265185 Inf 0 0 0.000219473678051534 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 0 11498 23707 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 1 0.999844409142079 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2288 3890 False False 0 0 0 0 0 0 0 Inf 1.3608069907404 Inf 0 0 0.000320776462830572 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Val50Gly rpoB_p.Val50Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2420 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2013 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Val517Met rpoB_p.Val517Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Val523Leu rpoB_p.Val523Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2503 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Val534Ala rpoB_p.Val534Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 30 0 16780 30532 0.00178465199286139 0.00120441111287972 0.00254672951354614 1 0.999879187193184 1 1 0.884296691777972 1 NA NA NA NA NA NA NA NA NA NA 2504 4649 False False Inf 13.9032074890251 Inf 0 0 0.000219813707158818 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 29 0 11473 23707 0.00252130064336637 0.00168918484735422 0.00361901681244135 1 0.999844409142079 1 1 0.880555130930497 1 NA NA NA NA NA NA NA NA NA NA 2081 3890 False False 0 0 0 0 0 0 0 Inf 15.2286924418819 Inf 0 0 0.000321475331688871 1 0.999844409142079 1 2 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Val534Gly rpoB_p.Val534Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2505 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Val534Leu rpoB_p.Val534Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2520 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2091 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Val534Met rpoB_p.Val534Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 51 1 16759 30531 0.00303390838786436 0.00225975300956642 0.00398712344893809 0.999967247478055 0.999817528289014 0.999999170778282 0.98076923076923 0.897446455347882 0.999513237584508 0 0 0.975 0 0 0.975 0 0 70.9735718563066 1 1627.5 4649 False False 92.9101378363864 15.9322505993564 3665.36408121247 0 0 0.000220089116183088 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 45 1 11457 23706 0.00391236306729264 0.00285509282253167 0.00523158571947652 0.999957818365883 0.999765001636458 0.999998932054057 0.978260869565217 0.88472817440201 0.999449764305119 0 0 0.975 0 0 0.975 0 0 80.5990275300823 1 1214.5 3890 False False 0 0 0 0 0 0 0 93.1107619795758 15.8821467718236 3681.90955989622 0 0 0.000321924208121855 0.999957818365883 0.999765001636458 0.999998932054057 3 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Val549Gly rpoB_p.Val549Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2634 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2192 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Val549Ile rpoB_p.Val549Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Val555Ala rpoB_p.Val555Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2691 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2240 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 2 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Val562Ala rpoB_p.Val562Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 7 0 16803 30532 0.000416418798334324 0.000167437820935922 0.000857792460925722 1 0.999879187193184 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 2759 4649 False False Inf 2.61832748907777 Inf 0 0 0.000219512858481393 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 7 0 11495 23707 0.000608589810467744 0.000244718560881119 0.00125352303681455 1 0.999844409142079 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 2303 3890 False False 0 0 0 0 0 0 0 Inf 2.97179240572548 Inf 0 0 0.000320860166613556 1 0.999844409142079 1 1 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Val562Met rpoB_p.Val562Met 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2402 4649 False False Inf 1.1990579265185 Inf 0 0 0.000219473678051534 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1996 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 3 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Val575Ala rpoB_p.Val575Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2590 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2153 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Val581Leu rpoB_p.Val581Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2560 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2128 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Val581Met rpoB_p.Val581Met 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2541 4649 False False Inf 1.1990579265185 Inf 0 0 0.000219473678051534 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 0 11498 23707 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 1 0.999844409142079 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2111 3890 False False 0 0 0 0 0 0 0 Inf 1.3608069907404 Inf 0 0 0.000320776462830572 1 0.999844409142079 1 3 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Val583Ala rpoB_p.Val583Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Val583Met rpoB_p.Val583Met 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2621 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2181 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Val613Ile rpoB_p.Val613Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Val613Phe rpoB_p.Val613Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.9820231071276 0.168448731581911 252 4649 False False 0 0 1.9820231071276 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 2.24912710990902 0.180424970179968 177 3890 False False 0 0 0 0 0 0 0 0 0 2.24912710990902 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 1 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Val695Leu rpoB_p.Val695Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 74 7 67 126 71 16684 30461 0.00749553837001784 0.00624771391726386 0.00891800892589955 0.997674570941962 0.997067679360014 0.998183387582008 0.639593908629441 0.568304456416881 0.706611933272995 0.0945945945945946 0.0388840269989353 0.185237616473473 0.0897435897435897 0.0368468962745884 0.176203472166872 0.190751171020944 0.0738371831434174 0.415227253758599 5.28803634003062e-07 30 4649 True False 3.24008327114448 2.40186624243415 4.39983602689383 0.000419387693966808 0.000168631698032096 0.00086390681014174 0.997674570941962 0.997067679360014 0.998183387582008 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 46 2 44 45 47 11457 23660 0.00391236306729264 0.00285509282253167 0.00523158571947652 0.998017463196524 0.99736450840227 0.998542954015614 0.489130434782608 0.38340930836456 0.595570585042346 0.0434782608695652 0.00530948284942996 0.148386775920115 0.0408163265306122 0.0049818418349713 0.139787187022463 0.0938687741515706 0.0110199005323971 0.359941724263259 4.87272437558209e-06 28 3890 True False 0 0 0 0 0 0 0 1.97723588106499 1.28325886904609 3.04308879681732 0.000174535299764377 2.11377334648136e-05 0.000630337797437458 0.998017463196524 0.99736450840227 0.998542954015614 5 Not assoc w R 3) Uncertain significance DOWN from NotAwR to Uncertain yes 2 +Rifampicin rpoB p.Val715Ala rpoB_p.Val715Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Val736Leu rpoB_p.Val736Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 6 0 16804 30532 0.000356930398572278 0.000130998068917797 0.000776724091447791 1 0.999879187193184 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 2488 4649 False False Inf 2.13890645017026 Inf 0 0 0.000219499796783869 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 0 11498 23707 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 1 0.999844409142079 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2069 3890 False False 0 0 0 0 0 0 0 Inf 1.3608069907404 Inf 0 0 0.000320776462830572 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Val740Thr rpoB_p.Val740Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2421 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2014 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Val77Met rpoB_p.Val77Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Val797Leu rpoB_p.Val797Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2662 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Val800Ala rpoB_p.Val800Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2591 4649 False False Inf 1.1990579265185 Inf 0 0 0.000219473678051534 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 0 11498 23707 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 1 0.999844409142079 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2154 3890 False False 0 0 0 0 0 0 0 Inf 1.3608069907404 Inf 0 0 0.000320776462830572 1 0.999844409142079 1 2 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Val833Met rpoB_p.Val833Met 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2708 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Val867Ala rpoB_p.Val867Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Val895Phe rpoB_p.Val895Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Val916Met rpoB_p.Val916Met 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2676 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2226 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Val946Gly rpoB_p.Val946Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Val970Ala rpoB_p.Val970Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2771 4649 False False Inf 1.1990579265185 Inf 0 0 0.000219473678051534 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 0 11498 23707 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 1 0.999844409142079 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2312 3890 False False 0 0 0 0 0 0 0 Inf 1.3608069907404 Inf 0 0 0.000320776462830572 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Val970Leu rpoB_p.Val970Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2521 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2092 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Val970Met rpoB_p.Val970Met 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 6 0 16804 30532 0.000356930398572278 0.000130998068917797 0.000776724091447791 1 0.999879187193184 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 2663 4649 False False Inf 2.13890645017026 Inf 0 0 0.000219499796783869 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 6 0 11496 23707 0.000521648408972352 0.000191459062774625 0.00113506056981396 1 0.999844409142079 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 2216 3890 False False 0 0 0 0 0 0 0 Inf 2.42738974088595 Inf 0 0 0.000320832260499258 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Val994Ala rpoB_p.Val994Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoB p.Val996Ala rpoB_p.Val996Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2489 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoB p.Val996Gly rpoB_p.Val996Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2606 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2167 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC c.1002G>C rpoC_c.1002G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1008C>G rpoC_c.1008C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1011G>C rpoC_c.1011G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.908144446427509 0.0153974005043644 17.4461131425891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1014C>T rpoC_c.1014C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1017C>T rpoC_c.1017C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1018_1020delTTGinsCTC rpoC_c.1018_1020delTTGinsCTC 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1018T>C rpoC_c.1018T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1020G>A rpoC_c.1020G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.102C>T rpoC_c.102C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 5 0 16805 30532 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 1 0.999879187193184 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.66460481015123 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 5 0 11497 23707 0.00043470700747696 0.000141162766530747 0.00101416710312943 1 0.999844409142079 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.88913119689894 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1035C>T rpoC_c.1035C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 3 16809 30529 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999901742434167 0.999712876815577 0.99997973646933 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.605409800305391 0.0115361654751757 7.54087213596152 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1036_1038delAGGinsCGC rpoC_c.1036_1038delAGGinsCGC 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1036A>C rpoC_c.1036A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1044C>T rpoC_c.1044C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1059G>C rpoC_c.1059G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.105C>T rpoC_c.105C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1062G>C rpoC_c.1062G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1065A>G rpoC_c.1065A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1066A>C rpoC_c.1066A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1068G>A rpoC_c.1068G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.908144446427509 0.0153974005043644 17.4461131425891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1069C>T rpoC_c.1069C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 3 16808 30529 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999901742434167 0.999712876815577 0.99997973646933 0.4 0.0527449505263169 0.853367200365326 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.21089163890211 0.101157890363798 10.5697741171107 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 3 11500 23704 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.99987345509765 0.999630227076139 0.999973902638554 0.4 0.0527449505263169 0.853367200365326 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.37414492753623 0.114734681491877 11.9942804069209 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1080G>T rpoC_c.1080G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.750576632084797 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1089G>C rpoC_c.1089G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1092A>G rpoC_c.1092A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1095C>T rpoC_c.1095C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1101C>T rpoC_c.1101C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1104C>T rpoC_c.1104C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 1 16807 30531 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999967247478055 0.999817528289014 0.999999170778282 0.75 0.194120449683243 0.99369053679029 NA NA NA NA NA NA NA NA NA NA NA NA False False 5.44969358005592 0.437509494081317 285.652299683162 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.111C>A rpoC_c.111C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1122G>A rpoC_c.1122G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1128A>G rpoC_c.1128A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.908144446427509 0.0153974005043644 17.4461131425891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1140G>C rpoC_c.1140G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1141C>T rpoC_c.1141C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.341150751115529 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1143G>T rpoC_c.1143G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1152T>C rpoC_c.1152T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 16810 30526 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.54251408011679 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 6 11502 23701 0 0 0.000320664925697395 0.9997469101953 0.999449212060655 0.99990711502044 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.75038628279554 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1155C>G rpoC_c.1155C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1158C>T rpoC_c.1158C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1161C>G rpoC_c.1161C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1161C>T rpoC_c.1161C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1164C>A rpoC_c.1164C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 11 0 16799 30532 0.00065437239738251 0.000326704163498642 0.00117055062018267 1 0.999879187193184 1 1 0.715085847081845 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 4.56066720991606 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1165C>A rpoC_c.1165C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1167G>T rpoC_c.1167G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1170C>G rpoC_c.1170C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1170C>T rpoC_c.1170C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1173C>T rpoC_c.1173C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1176C>A rpoC_c.1176C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1179G>T rpoC_c.1179G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.117T>C rpoC_c.117T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.908144446427509 0.0153974005043644 17.4461131425891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1191T>C rpoC_c.1191T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1197C>G rpoC_c.1197C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1206T>G rpoC_c.1206T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1236G>C rpoC_c.1236G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1239C>T rpoC_c.1239C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.123G>A rpoC_c.123G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.123G>C rpoC_c.123G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1242G>T rpoC_c.1242G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1249C>T rpoC_c.1249C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1254C>G rpoC_c.1254C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1257C>T rpoC_c.1257C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.908144446427509 0.0153974005043644 17.4461131425891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1263T>C rpoC_c.1263T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.6329128986197 0.189104318453829 214.057761575796 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1272C>T rpoC_c.1272C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1275G>C rpoC_c.1275G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1275G>T rpoC_c.1275G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1281_1284delGTCGinsTAGC rpoC_c.1281_1284delGTCGinsTAGC 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1281G>T rpoC_c.1281G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1284G>A rpoC_c.1284G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 13 16810 30519 0 0 0.000219421459229958 0.999574217214725 0.999272008529012 0.999773269742809 0 0 0.24705263800047 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.595805680834415 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 13 11502 23694 0 0 0.000320664925697395 0.999451638756485 0.999062468123692 0.999707989454911 0 0 0.24705263800047 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.676068752178923 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1293G>C rpoC_c.1293G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1299C>T rpoC_c.1299C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1308C>G rpoC_c.1308C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1320G>A rpoC_c.1320G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1323C>T rpoC_c.1323C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.132C>T rpoC_c.132C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 24 7 16786 30525 0.00142772159428911 0.000914975681329737 0.00212359656152999 0.99977073234639 0.999527678427408 0.999907817703152 0.774193548387096 0.589036133861326 0.904057831654248 NA NA NA NA NA NA NA NA NA NA NA NA False False 6.23478749297884 2.60557234917694 17.135653053259 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 24 6 11478 23701 0.00208659363588941 0.001337363263423 0.00310310526233451 0.9997469101953 0.999449212060655 0.99990711502044 0.8 0.614333489003392 0.922864487998934 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 8.25962711273741 3.28770741034274 24.7097809840756 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1332C>G rpoC_c.1332C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1332C>T rpoC_c.1332C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1338G>C rpoC_c.1338G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1344G>C rpoC_c.1344G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1344G>T rpoC_c.1344G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1347G>C rpoC_c.1347G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1353G>A rpoC_c.1353G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1356C>T rpoC_c.1356C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1365C>T rpoC_c.1365C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1374G>A rpoC_c.1374G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1377G>T rpoC_c.1377G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1380G>A rpoC_c.1380G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1383G>C rpoC_c.1383G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.6329128986197 0.189104318453829 214.057761575796 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1389C>G rpoC_c.1389C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.138G>A rpoC_c.138G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.750576632084797 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1395T>C rpoC_c.1395T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 2 16808 30530 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999934494956111 0.999763393503742 0.99999206693684 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.8163969538315 0.131636449523742 25.0652602654423 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 2 11500 23705 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999915636731767 0.999695284447545 0.999989783053538 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06130434782608 0.149383229063395 28.4413197127326 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1413C>T rpoC_c.1413C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1419G>A rpoC_c.1419G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1422C>G rpoC_c.1422C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1434C>T rpoC_c.1434C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1440C>T rpoC_c.1440C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 7 81 16803 30451 0.000416418798334324 0.000167437820935922 0.000857792460925722 0.99734704572252 0.996703682976178 0.99789263010431 0.0795454545454545 0.0325800073749997 0.157048708087539 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.156612979898504 0.0610290018678329 0.337776990109869 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 7 78 11495 23629 0.000608589810467744 0.000244718560881119 0.00125352303681455 0.996709832538912 0.995895398569868 0.997398416600873 0.0823529411764705 0.0337525436178748 0.162343904723825 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 0 0.184475970600372 0.0717665486039348 0.398575978340127 NA NA NA NA NA NA 2 5) Not assoc w R Now listed Silent mutation no 0 +Rifampicin rpoC c.1446A>G rpoC_c.1446A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.908144446427509 0.0153974005043644 17.4461131425891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1449G>A rpoC_c.1449G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1449G>T rpoC_c.1449G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.144C>T rpoC_c.144C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 1 16807 30531 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999967247478055 0.999817528289014 0.999999170778282 0.75 0.194120449683243 0.99369053679029 NA NA NA NA NA NA NA NA NA NA NA NA False False 5.44969358005592 0.437509494081317 285.652299683162 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 1 11499 23706 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.999957818365883 0.999765001636458 0.999998932054057 0.75 0.194120449683243 0.99369053679029 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 6.18471171406209 0.496496186771195 324.103527365594 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1455T>C rpoC_c.1455T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1458G>A rpoC_c.1458G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.341150751115529 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1458G>C rpoC_c.1458G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1473C>A rpoC_c.1473C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1489T>C rpoC_c.1489T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.6329128986197 0.189104318453829 214.057761575796 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1494G>C rpoC_c.1494G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1500C>T rpoC_c.1500C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.341150751115529 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1503A>G rpoC_c.1503A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1506C>A rpoC_c.1506C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1518G>C rpoC_c.1518G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1519T>C rpoC_c.1519T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.153C>T rpoC_c.153C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1548G>A rpoC_c.1548G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1554A>G rpoC_c.1554A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1563C>A rpoC_c.1563C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1563C>T rpoC_c.1563C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1569G>A rpoC_c.1569G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1575C>T rpoC_c.1575C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1579_1581delTTGinsCTC rpoC_c.1579_1581delTTGinsCTC 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1579T>C rpoC_c.1579T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1593G>C rpoC_c.1593G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1596C>T rpoC_c.1596C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1599T>C rpoC_c.1599T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.159G>A rpoC_c.159G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.-15G>A rpoC_c.-15G>A 2 upstream_gene_variant 763355 1 4 1 3 3 3 16807 30529 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999901742434167 0.999712876815577 0.99997973646933 0.5 0.118117248757025 0.881882751242974 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.605481842882925 0.0115375375438011 7.54176961558293 1 1627.5 4649 False False 1.81644552864877 0.243258979140325 13.5672775646283 5.94954783436458e-05 1.50629396217601e-06 0.000331442511213996 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 1 3 3 3 11499 23704 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.99987345509765 0.999630227076139 0.999973902638554 0.5 0.118117248757025 0.881882751242974 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.687132214395454 0.0130923333464562 8.55922137889951 1 504 3890 False False 0 0 0 0 0 0 0 2.06139664318636 0.276050319534324 15.3984166853777 8.69565217391304e-05 2.20154609696687e-06 0.000484394439799471 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC c.1614T>C rpoC_c.1614T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1626C>G rpoC_c.1626C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2395 3545 14415 26987 0.142474717430101 0.137223231930872 0.147850225022847 0.883892309707847 0.880245999309302 0.887465401637375 0.403198653198653 0.390689907316168 0.415802552030552 NA NA NA NA NA NA NA NA NA NA NA NA False True 1.26482150361513 1.19581185364882 1.33765870627433 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 1495 2737 10007 20970 0.129977395235611 0.123882584305725 0.136260145401546 0.884548867423124 0.880412662421514 0.888590537371133 0.353260869565217 0.33884729003289 0.367877268496509 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 1 1.14461893481285 1.06928087207735 1.22496136637789 NA NA NA NA NA NA 439 5) Not assoc w R Now listed Silent mutation no 0 +Rifampicin rpoC c.162G>C rpoC_c.162G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 57 841 16753 29691 0.00339083878643664 0.0025691692652669 0.00439102203662388 0.972455129044936 0.970557388675627 0.974262244966954 0.0634743875278396 0.0484257914971489 0.0814596729715039 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.120118830829667 0.0901489977320302 0.157312101240827 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 49 786 11453 22921 0.00426012867327421 0.00315327871903489 0.00562825025580817 0.966845235584426 0.964487062381462 0.969088031982687 0.0586826347305389 0.0437254413117903 0.0768425641496307 NA NA NA NA NA NA NA NA NA NA NA NA False True 1 1 1 0 0 0 1 0.12476358183873 0.0914275862072348 0.166754304943948 NA NA NA NA NA NA 31 5) Not assoc w R Now listed Silent mutation no 0 +Rifampicin rpoC c.162G>T rpoC_c.162G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1632C>T rpoC_c.1632C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1635_1650delGCCTTTGAGCGCCGAAinsCCCGCTGTCGGCGGAG rpoC_c.1635_1650delGCCTTTGAGCGCCGAAinsCCCGCTGTCGGCGGAG 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1638T>G rpoC_c.1638T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1639T>C rpoC_c.1639T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1644C>T rpoC_c.1644C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 6 16808 30526 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999803484868334 0.999572318737888 0.999927879105266 0.25 0.0318540262499442 0.650855794412824 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.605386323972711 0.0597336972185117 3.38610801139962 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 6 11500 23701 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.9997469101953 0.999449212060655 0.99990711502044 0.25 0.0318540262499442 0.650855794412824 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.686985507246376 0.0677936853587072 3.84271972888173 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1647C>A rpoC_c.1647C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1650A>G rpoC_c.1650A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1653G>A rpoC_c.1653G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 9 16810 30523 0 0 0.000219421459229958 0.999705227302502 0.999440503684993 0.999865202576615 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.920078094923294 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 9 11502 23698 0 0 0.000320664925697395 0.999620365292951 0.999279457952852 0.99982639261309 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.04405446176545 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1665T>A rpoC_c.1665T>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1668C>T rpoC_c.1668C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1671T>C rpoC_c.1671T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1672T>C rpoC_c.1672T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1674G>A rpoC_c.1674G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.1990579265185 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 4 0 11498 23707 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 1 0.999844409142079 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.3608069907404 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1678T>C rpoC_c.1678T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1683C>G rpoC_c.1683C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1686C>G rpoC_c.1686C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.-16delG rpoC_c.-16delG 2 upstream_gene_variant 763353 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC c.1704G>A rpoC_c.1704G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1704G>C rpoC_c.1704G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1707A>C rpoC_c.1707A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1710T>G rpoC_c.1710T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1713G>C rpoC_c.1713G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1719G>T rpoC_c.1719G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1720T>C rpoC_c.1720T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1725C>T rpoC_c.1725C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1734G>A rpoC_c.1734G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1734G>C rpoC_c.1734G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1735C>T rpoC_c.1735C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1749C>G rpoC_c.1749C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1749C>T rpoC_c.1749C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 8 16810 30524 0 0 0.000219421459229958 0.999737979824446 0.999483781433772 0.999886871715824 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.06393155676265 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.12235036001139 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1752G>A rpoC_c.1752G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 26 86 16784 30446 0.0015466983938132 0.00101059577405045 0.00226545603351431 0.997183283112799 0.996522529349069 0.997746391405141 0.232142857142857 0.157592176672009 0.321353725072989 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.54841543441151 0.339219990961982 0.859380295890211 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 20 67 11482 23640 0.00173882802990784 0.00106243473911297 0.00268420764151461 0.997173830514194 0.996412234433144 0.997809106640521 0.229885057471264 0.146430630394063 0.332467894781233 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.614589480744682 0.353025844028663 1.02606914130655 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1755G>C rpoC_c.1755G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1761C>T rpoC_c.1761C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1773G>A rpoC_c.1773G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1776C>G rpoC_c.1776C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 12 1 16798 30531 0.000713860797144556 0.000368914962606047 0.00124663876852724 0.999967247478055 0.999817528289014 0.999999170778282 0.923076923076923 0.639702564732122 0.998054371502653 NA NA NA NA NA NA NA NA NA NA NA NA False False 21.8104536254316 3.22631137889576 928.24059648621 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 10 1 11492 23706 0.000869414014953921 0.000416994043678715 0.001598300185227 0.999957818365883 0.999765001636458 0.999998932054057 0.909090909090909 0.587220083011617 0.997701027786185 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 20.6282631395753 2.93373003427251 891.367911239421 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1776C>T rpoC_c.1776C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1779C>T rpoC_c.1779C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.177A>G rpoC_c.177A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 2 16808 30530 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999934494956111 0.999763393503742 0.99999206693684 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.8163969538315 0.131636449523742 25.0652602654423 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 2 11500 23705 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999915636731767 0.999695284447545 0.999989783053538 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06130434782608 0.149383229063395 28.4413197127326 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1809C>T rpoC_c.1809C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.180C>T rpoC_c.180C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.750576632084797 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1818C>T rpoC_c.1818C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 21 16808 30511 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999312197039172 0.998948811248646 0.999574190302931 0.0869565217391304 0.0107099660378758 0.280379335909411 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.172882527594569 0.0196555409248292 0.707418946198769 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 20 11500 23687 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.99915636731767 0.998697376967606 0.99948461349205 0.0909090909090909 0.0112055860241509 0.291612741553933 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.205973913043478 0.0233643584771898 0.848168983349934 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1821G>A rpoC_c.1821G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 16810 30526 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.54251408011679 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 6 11502 23701 0 0 0.000320664925697395 0.9997469101953 0.999449212060655 0.99990711502044 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.75038628279554 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1821G>T rpoC_c.1821G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1830T>C rpoC_c.1830T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1833C>T rpoC_c.1833C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 12 16806 30520 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999606969736669 0.999313555980458 0.999796899563454 0.25 0.0726620382528822 0.523770819896127 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.605339362925939 0.14226654487491 1.99765945449185 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 10 11499 23697 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.999578183658835 0.999224402000993 0.999797704727851 0.23076923076923 0.0503810734911515 0.53813153923404 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.618236368379859 0.109286484837531 2.40155388397479 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1836C>T rpoC_c.1836C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.183C>T rpoC_c.183C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 89 45 16721 30487 0.00529446757882213 0.00425398574542891 0.00651131741998265 0.998526136512511 0.998028346127193 0.998924756991139 0.664179104477612 0.577517414411905 0.743403717118844 NA NA NA NA NA NA NA NA NA NA NA NA False True 3.60603499259082 2.4909000584719 5.28472462510349 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 54 42 11448 23665 0.00469483568075117 0.00352881433863449 0.00612135663096333 0.998228371367106 0.997606018992145 0.998722876779403 0.5625 0.457461465971705 0.66357707082404 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 1 2.65779424977538 1.7418359110093 4.07999856695012 NA NA NA NA NA NA 62 5) Not assoc w R Now listed Silent mutation no 0 +Rifampicin rpoC c.1842G>T rpoC_c.1842G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1848C>T rpoC_c.1848C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1854G>T rpoC_c.1854G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 6 0 16804 30532 0.000356930398572278 0.000130998068917797 0.000776724091447791 1 0.999879187193184 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 2.13890645017026 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1857C>A rpoC_c.1857C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.186C>T rpoC_c.186C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 194 37 16616 30495 0.011540749553837 0.00998136834883597 0.0132723875144997 0.998788156688065 0.998330016628398 0.999146611401903 0.839826839826839 0.786046284349162 0.884646497508514 NA NA NA NA NA NA NA NA NA NA NA NA False False 9.62281552134705 6.73803998950202 14.0828764311472 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 127 12 11375 23695 0.0110415579899147 0.00921293021365061 0.0131235650208128 0.999493820390602 0.999115973206486 0.999738423129043 0.913669064748201 0.854053100710773 0.954593950514346 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 22.0458974358974 12.1831764573125 43.8157627695318 NA NA NA NA NA NA 160 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1878C>G rpoC_c.1878C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1879T>C rpoC_c.1879T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 16810 30526 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.54251408011679 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.24912710990902 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.189C>T rpoC_c.189C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.18C>T rpoC_c.18C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.-18T>A rpoC_c.-18T>A 2 upstream_gene_variant 763352 NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3677 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3074 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC c.1905G>T rpoC_c.1905G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 16810 30526 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.54251408011679 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.12235036001139 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1908G>C rpoC_c.1908G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1914C>G rpoC_c.1914C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1920G>A rpoC_c.1920G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1926G>A rpoC_c.1926G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1929G>A rpoC_c.1929G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1948C>T rpoC_c.1948C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1950A>G rpoC_c.1950A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1956C>T rpoC_c.1956C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 7 16808 30525 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.99977073234639 0.999527678427408 0.999907817703152 0.222222222222222 0.0281449734778982 0.600093573716312 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.518885564697083 0.0525913141752312 2.72565212094981 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 7 11500 23700 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999704728561184 0.999391723222185 0.999881277590374 0.222222222222222 0.0281449734778982 0.600093573716312 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.588819875776397 0.0596633171436625 3.09306705863206 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1962C>T rpoC_c.1962C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.6329128986197 0.189104318453829 214.057761575796 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1980T>C rpoC_c.1980T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1983G>A rpoC_c.1983G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.1983G>C rpoC_c.1983G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.-19T>C rpoC_c.-19T>C 2 upstream_gene_variant 763351 NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3485 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2904 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC c.2001G>A rpoC_c.2001G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2001G>C rpoC_c.2001G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2004G>A rpoC_c.2004G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2004G>C rpoC_c.2004G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2004G>T rpoC_c.2004G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2013G>T rpoC_c.2013G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2019C>T rpoC_c.2019C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.201G>C rpoC_c.201G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2028G>A rpoC_c.2028G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2037G>C rpoC_c.2037G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2037G>T rpoC_c.2037G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2040T>G rpoC_c.2040T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2046G>A rpoC_c.2046G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2049C>T rpoC_c.2049C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 7 16809 30525 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.99977073234639 0.999527678427408 0.999907817703152 0.125 0.0031597235312519 0.526509670875206 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.2594273475944 0.00575995110596449 2.01970184240593 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 6 11502 23701 0 0 0.000320664925697395 0.9997469101953 0.999449212060655 0.99990711502044 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.75038628279554 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.204G>C rpoC_c.204G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2052C>G rpoC_c.2052C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2055C>T rpoC_c.2055C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2070G>A rpoC_c.2070G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2076G>A rpoC_c.2076G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2076G>C rpoC_c.2076G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2076G>T rpoC_c.2076G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.207C>T rpoC_c.207C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2085C>G rpoC_c.2085C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2085C>T rpoC_c.2085C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2091C>T rpoC_c.2091C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2100G>C rpoC_c.2100G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2103C>T rpoC_c.2103C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2109T>C rpoC_c.2109T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 5 16809 30527 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999836237390279 0.999617874429585 0.999946824656822 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.363222083407698 0.00768325476784986 3.24674897733262 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.24912710990902 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.210C>T rpoC_c.210C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2115G>T rpoC_c.2115G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2130C>G rpoC_c.2130C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2136C>T rpoC_c.2136C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2139C>G rpoC_c.2139C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.213G>A rpoC_c.213G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2148C>G rpoC_c.2148C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2157C>G rpoC_c.2157C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2175_2187delCCGCAGCGGCGTGinsGCGTTCGGGTGTC rpoC_c.2175_2187delCCGCAGCGGCGTGinsGCGTTCGGGTGTC 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2178C>G rpoC_c.2178C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2178C>T rpoC_c.2178C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2184C>T rpoC_c.2184C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2193G>T rpoC_c.2193G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.219C>T rpoC_c.219C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.21C>T rpoC_c.21C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 6 16809 30526 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999803484868334 0.999572318737888 0.999927879105266 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.302675154183274 0.00658396461982027 2.49513982006856 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 6 11501 23701 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.9997469101953 0.999449212060655 0.99990711502044 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.343462887285163 0.00747035147172492 2.83150389371471 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2202C>A rpoC_c.2202C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2208G>A rpoC_c.2208G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2211G>A rpoC_c.2211G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2247C>T rpoC_c.2247C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2256C>G rpoC_c.2256C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2259G>C rpoC_c.2259G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.225C>T rpoC_c.225C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.6329128986197 0.189104318453829 214.057761575796 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2286T>C rpoC_c.2286T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2289C>A rpoC_c.2289C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2289C>T rpoC_c.2289C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.908144446427509 0.0153974005043644 17.4461131425891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2293_2295delTTGinsCTC rpoC_c.2293_2295delTTGinsCTC 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.-22C>T rpoC_c.-22C>T 2 upstream_gene_variant 763348 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 80.2910622977969 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC c.2313C>T rpoC_c.2313C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.231C>T rpoC_c.231C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2331T>C rpoC_c.2331T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.234C>T rpoC_c.234C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2352G>A rpoC_c.2352G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2355C>G rpoC_c.2355C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2365T>C rpoC_c.2365T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2370G>C rpoC_c.2370G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2376C>T rpoC_c.2376C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2385C>T rpoC_c.2385C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2400C>T rpoC_c.2400C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2403C>T rpoC_c.2403C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2421C>T rpoC_c.2421C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.243G>A rpoC_c.243G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2442T>C rpoC_c.2442T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2445A>G rpoC_c.2445A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2451G>A rpoC_c.2451G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2454C>A rpoC_c.2454C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2454C>T rpoC_c.2454C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2457T>C rpoC_c.2457T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2466C>T rpoC_c.2466C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.908144446427509 0.0153974005043644 17.4461131425891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2467C>T rpoC_c.2467C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.246G>C rpoC_c.246G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2472G>T rpoC_c.2472G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2481G>C rpoC_c.2481G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2490G>A rpoC_c.2490G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2499G>T rpoC_c.2499G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2502T>G rpoC_c.2502T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2508C>T rpoC_c.2508C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2514C>T rpoC_c.2514C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2517C>T rpoC_c.2517C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2520C>T rpoC_c.2520C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 5 16807 30527 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999836237390279 0.999617874429585 0.999946824656822 0.375 0.0852334141372535 0.755136783633448 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.08979591836734 0.169210020231233 5.60160594690905 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 5 11499 23702 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.999789091829417 0.999507879904061 0.999931515258336 0.375 0.0852334141372535 0.755136783633448 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.23673362901121 0.192018665186314 6.3579370602117 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2523T>C rpoC_c.2523T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2535C>G rpoC_c.2535C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2538G>T rpoC_c.2538G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2541G>C rpoC_c.2541G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2547C>T rpoC_c.2547C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.75142405620251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.12235036001139 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2553C>T rpoC_c.2553C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2559C>G rpoC_c.2559C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2559C>T rpoC_c.2559C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.750576632084797 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.255C>G rpoC_c.255C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2562C>T rpoC_c.2562C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2568T>C rpoC_c.2568T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2571A>T rpoC_c.2571A>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2577C>A rpoC_c.2577C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2578T>C rpoC_c.2578T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2586C>T rpoC_c.2586C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2592G>A rpoC_c.2592G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2598C>T rpoC_c.2598C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2604C>T rpoC_c.2604C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.341150751115529 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2610C>G rpoC_c.2610C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2613C>T rpoC_c.2613C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2619G>A rpoC_c.2619G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 16 19 16794 30513 0.000951814396192742 0.000544138942285324 0.00154522796648703 0.99937770208306 0.999028374542228 0.999625295739155 0.457142857142857 0.288271443790756 0.633541982878547 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.53002011996765 0.735675533373114 3.14203202527192 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 10 15 11492 23692 0.000869414014953921 0.000416994043678715 0.001598300185227 0.999367275488252 0.9989566315242 0.999645827023281 0.4 0.211254806465142 0.61334650374316 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.37440538345515 0.551987243596644 3.27168513163689 NA NA NA NA NA NA 14 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.261G>A rpoC_c.261G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2622C>T rpoC_c.2622C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2625A>T rpoC_c.2625A>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2637C>T rpoC_c.2637C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.75142405620251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2640G>A rpoC_c.2640G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2640G>C rpoC_c.2640G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2643C>G rpoC_c.2643C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 28 16808 30504 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999082929385562 0.99867484826652 0.999390529439302 0.0666666666666666 0.00817813446065631 0.220735401522961 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.129632147956755 0.0149427348374405 0.514186333525083 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 21 11500 23686 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999114185683553 0.998646255755329 0.99945158598871 0.0869565217391304 0.0107099660378758 0.280379335909411 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.19615734989648 0.0222949213382735 0.802741106677126 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2646G>A rpoC_c.2646G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.264T>C rpoC_c.264T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.750576632084797 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2655C>T rpoC_c.2655C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2661C>T rpoC_c.2661C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2673C>T rpoC_c.2673C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2679C>G rpoC_c.2679C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2679C>T rpoC_c.2679C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2682G>A rpoC_c.2682G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 9 16809 30523 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999705227302502 0.999440503684993 0.999865202576615 0.1 0.00252857854446178 0.445016117028195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.201763605475902 0.00460699063398853 1.45637661246692 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 7 11501 23700 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999704728561184 0.999391723222185 0.999881277590374 0.125 0.0031597235312519 0.526509670875206 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.294384339250003 0.00653526389697788 2.29204336611244 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2685C>A rpoC_c.2685C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2701C>T rpoC_c.2701C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 114 16809 30418 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.996266212498362 0.995516267449921 0.996919128125244 0.00869565217391304 0.000220130619736184 0.0474969468849952 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.0158739104886375 0.000403386765502702 0.0902559043830838 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 0 106 11502 23601 0 0 0.000320664925697395 0.99552874678365 0.994594682488822 0.996337895849787 0 0 0.0342021672763502 NA NA NA NA NA NA NA NA NA NA NA NA False True 1 1 1 0 0 0 0 0 0 0.0726873815282204 NA NA NA NA NA NA 2 5) Not assoc w R Now listed Silent mutation no 0 +Rifampicin rpoC c.2706C>G rpoC_c.2706C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2715A>G rpoC_c.2715A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.341150751115529 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2721C>T rpoC_c.2721C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2724C>G rpoC_c.2724C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2724C>T rpoC_c.2724C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.273G>C rpoC_c.273G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2742G>A rpoC_c.2742G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2766G>A rpoC_c.2766G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2772C>G rpoC_c.2772C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2773C>T rpoC_c.2773C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2784C>T rpoC_c.2784C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.27A>G rpoC_c.27A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.-27T>G rpoC_c.-27T>G 2 upstream_gene_variant 763343 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC c.2814C>T rpoC_c.2814C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2817G>A rpoC_c.2817G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2820T>C rpoC_c.2820T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2823T>C rpoC_c.2823T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2841G>A rpoC_c.2841G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2847T>C rpoC_c.2847T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2853T>C rpoC_c.2853T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2853T>G rpoC_c.2853T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.285C>T rpoC_c.285C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2862T>C rpoC_c.2862T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 22 16810 30510 0 0 0.000219421459229958 0.999279444517227 0.998909272375137 0.999548378362908 0 0 0.154372512815574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.331393813311992 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 18 11502 23689 0 0 0.000320664925697395 0.999240730585902 0.998800291409329 0.999549948712402 0 0 0.185301968137852 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.468558999031164 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2865T>C rpoC_c.2865T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2868T>C rpoC_c.2868T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2874C>A rpoC_c.2874C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2874C>T rpoC_c.2874C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.288G>A rpoC_c.288G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.-28C>A rpoC_c.-28C>A 2 upstream_gene_variant 763342 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 1 3) Uncertain significance No change no 1 +Rifampicin rpoC c.2907C>T rpoC_c.2907C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.291T>C rpoC_c.291T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.9820231071276 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.12235036001139 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.291T>G rpoC_c.291T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.341150751115529 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2922G>A rpoC_c.2922G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2928G>A rpoC_c.2928G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2931C>T rpoC_c.2931C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2934C>T rpoC_c.2934C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2937C>T rpoC_c.2937C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2940G>C rpoC_c.2940G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2940G>T rpoC_c.2940G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2952C>T rpoC_c.2952C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2979A>G rpoC_c.2979A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.297G>C rpoC_c.297G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2982C>T rpoC_c.2982C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.2994G>A rpoC_c.2994G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.300C>G rpoC_c.300C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3018C>A rpoC_c.3018C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3018C>G rpoC_c.3018C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 5 5 16805 30527 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 0.999836237390279 0.999617874429585 0.999946824656822 0.5 0.187086028447398 0.812913971552601 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.8165426956263 0.417993991073695 7.89433539000939 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 5 1 11497 23706 0.00043470700747696 0.000141162766530747 0.00101416710312943 0.999957818365883 0.999765001636458 0.999998932054057 0.833333333333333 0.358765421002325 0.99578925548551 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 10.3096459946072 1.15337945963023 486.419600220716 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3024C>T rpoC_c.3024C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 6 15 16804 30517 0.000356930398572278 0.000130998068917797 0.000776724091447791 0.999508712170837 0.99918982468991 0.9997250046892 0.285714285714285 0.11280940392194 0.521751118247113 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.726422280409426 0.230853342653668 1.98167471839665 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 6 15 11496 23692 0.000521648408972352 0.000191459062774625 0.00113506056981396 0.999367275488252 0.9989566315242 0.999645827023281 0.285714285714285 0.11280940392194 0.521751118247113 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.824356297842727 0.261995211750955 2.24908993958818 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3027G>A rpoC_c.3027G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3030G>A rpoC_c.3030G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3033C>T rpoC_c.3033C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3039C>T rpoC_c.3039C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.303C>G rpoC_c.303C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3051G>A rpoC_c.3051G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 3 16808 30529 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999901742434167 0.999712876815577 0.99997973646933 0.4 0.0527449505263169 0.853367200365326 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.21089163890211 0.101157890363798 10.5697741171107 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 3 11500 23704 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.99987345509765 0.999630227076139 0.999973902638554 0.4 0.0527449505263169 0.853367200365326 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.37414492753623 0.114734681491877 11.9942804069209 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.306C>G rpoC_c.306C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.306C>T rpoC_c.306C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3084G>A rpoC_c.3084G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3087C>T rpoC_c.3087C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3093G>A rpoC_c.3093G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.309C>T rpoC_c.309C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 6 16808 30526 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999803484868334 0.999572318737888 0.999927879105266 0.25 0.0318540262499442 0.650855794412824 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.605386323972711 0.0597336972185117 3.38610801139962 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 5 11501 23702 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999789091829417 0.999507879904061 0.999931515258336 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.412172854534388 0.00871781959321125 3.68423590106777 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3126C>T rpoC_c.3126C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3144C>T rpoC_c.3144C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3165C>T rpoC_c.3165C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3180G>A rpoC_c.3180G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.75142405620251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3183C>T rpoC_c.3183C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3204T>G rpoC_c.3204T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3207C>T rpoC_c.3207C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3210C>T rpoC_c.3210C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3213C>A rpoC_c.3213C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 28 144 16782 30388 0.00166567519333729 0.00110710558710172 0.00240647153309903 0.995283636840036 0.99444967372518 0.996021080900249 0.162790697674418 0.110982172689323 0.226611336272189 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.352090202465604 0.2259488770508 0.530850348974972 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 21 135 11481 23572 0.00182576943140323 0.00113052422891288 0.00278953561568501 0.994305479394271 0.993263373209886 0.995223416269876 0.134615384615384 0.0852995621947257 0.19838591354613 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 0 0.31937597383116 0.191359471188808 0.50846662923012 NA NA NA NA NA NA 15 5) Not assoc w R Now listed Silent mutation no 0 +Rifampicin rpoC c.3213C>T rpoC_c.3213C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 7 16810 30525 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.26007067420399 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 6 11502 23701 0 0 0.000320664925697395 0.9997469101953 0.999449212060655 0.99990711502044 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.75038628279554 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.321C>T rpoC_c.321C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 8 16806 30524 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999737979824446 0.999483781433772 0.999886871715824 0.333333333333333 0.0992460911495833 0.651124493581186 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.908128049506128 0.200090516675031 3.39037213523386 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 4 11500 23703 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999831273463534 0.999568049920357 0.99995402584539 0.333333333333333 0.0432718682927417 0.777221904496487 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.0305652173913 0.0931903474189042 7.19201282268065 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3228C>G rpoC_c.3228C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3234C>T rpoC_c.3234C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.9820231071276 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3240C>A rpoC_c.3240C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3243C>A rpoC_c.3243C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3256C>T rpoC_c.3256C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3258G>A rpoC_c.3258G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3264G>A rpoC_c.3264G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3270G>A rpoC_c.3270G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.327T>A rpoC_c.327T>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.327T>C rpoC_c.327T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3289C>A rpoC_c.3289C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3297C>T rpoC_c.3297C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3300C>T rpoC_c.3300C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3309C>T rpoC_c.3309C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 7 16810 30525 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.26007067420399 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 7 11502 23700 0 0 0.000320664925697395 0.999704728561184 0.999391723222185 0.999881277590374 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.42986888806462 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3315C>T rpoC_c.3315C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3327G>A rpoC_c.3327G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3333G>A rpoC_c.3333G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.333C>G rpoC_c.333C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.908144446427509 0.0153974005043644 17.4461131425891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.333C>T rpoC_c.333C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.9820231071276 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.12235036001139 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3342C>T rpoC_c.3342C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3372G>A rpoC_c.3372G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.75142405620251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3390G>A rpoC_c.3390G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 21 24 16789 30508 0.00124925639500297 0.000773470498752546 0.00190899053306069 0.999213939473339 0.99883062854842 0.999496293299407 0.466666666666666 0.316600822997423 0.621279983912535 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.58999940437191 0.841537863668869 2.98200318553816 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 19 24 11483 23683 0.00165188662841245 0.000994827479836083 0.00257842889005257 0.998987640781203 0.998494061778372 0.999351258026211 0.441860465116279 0.290781177881064 0.601246135391518 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.63276510203489 0.845210062599849 3.11123778239387 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3390G>C rpoC_c.3390G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3396A>C rpoC_c.3396A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3399C>T rpoC_c.3399C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.339G>A rpoC_c.339G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.33C>T rpoC_c.33C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3400C>T rpoC_c.3400C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3402G>A rpoC_c.3402G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3405T>G rpoC_c.3405T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3414C>G rpoC_c.3414C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3420G>A rpoC_c.3420G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 7 16808 30525 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.99977073234639 0.999527678427408 0.999907817703152 0.222222222222222 0.0281449734778982 0.600093573716312 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.518885564697083 0.0525913141752312 2.72565212094981 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 7 11500 23700 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999704728561184 0.999391723222185 0.999881277590374 0.222222222222222 0.0281449734778982 0.600093573716312 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.588819875776397 0.0596633171436625 3.09306705863206 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3423C>A rpoC_c.3423C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3423C>G rpoC_c.3423C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3429C>A rpoC_c.3429C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3429C>G rpoC_c.3429C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3429C>T rpoC_c.3429C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.342G>A rpoC_c.342G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3435A>G rpoC_c.3435A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3438T>C rpoC_c.3438T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3441G>A rpoC_c.3441G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3444G>A rpoC_c.3444G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3459C>T rpoC_c.3459C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.75142405620251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.345G>C rpoC_c.345G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3468G>C rpoC_c.3468G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3471C>T rpoC_c.3471C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.75142405620251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3474T>C rpoC_c.3474T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3474T>G rpoC_c.3474T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3477C>A rpoC_c.3477C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3477C>G rpoC_c.3477C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3477C>T rpoC_c.3477C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3489C>T rpoC_c.3489C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.348T>C rpoC_c.348T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3492G>C rpoC_c.3492G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3498C>G rpoC_c.3498C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3498C>T rpoC_c.3498C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.1990579265185 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3507C>T rpoC_c.3507C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.341150751115529 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3510G>A rpoC_c.3510G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3513C>T rpoC_c.3513C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3522G>A rpoC_c.3522G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3537G>T rpoC_c.3537G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3538C>T rpoC_c.3538C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3549C>T rpoC_c.3549C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3552G>A rpoC_c.3552G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.908144446427509 0.0153974005043644 17.4461131425891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3564A>C rpoC_c.3564A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.75142405620251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3573C>T rpoC_c.3573C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3576A>C rpoC_c.3576A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3576A>G rpoC_c.3576A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.358C>T rpoC_c.358C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3594T>C rpoC_c.3594T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3606C>T rpoC_c.3606C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3609C>G rpoC_c.3609C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3615G>A rpoC_c.3615G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 4 16809 30528 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999868989912223 0.999664596427238 0.999964303043777 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.454042477244333 0.00922341562850508 4.58878013974823 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 4 11501 23703 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999831273463534 0.999568049920357 0.99995402584539 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.515237805408225 0.0104655802548345 5.20753049950472 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3627C>A rpoC_c.3627C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3627C>T rpoC_c.3627C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.908144446427509 0.0153974005043644 17.4461131425891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3633G>C rpoC_c.3633G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.908144446427509 0.0153974005043644 17.4461131425891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3639G>A rpoC_c.3639G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 3 16809 30529 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999901742434167 0.999712876815577 0.99997973646933 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.605409800305391 0.0115361654751757 7.54087213596152 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 3 11501 23704 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.99987345509765 0.999630227076139 0.999973902638554 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.687012723531287 0.0130900577164196 8.55773267307823 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3642G>C rpoC_c.3642G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 10 16806 30522 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999672474780558 0.999397752220648 0.999842928110511 0.285714285714285 0.0838893183071275 0.581035257183661 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.726454837558015 0.166280621466493 2.51917836313751 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 8 11499 23699 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.999662546927068 0.999335191784523 0.999854300817065 0.272727272727272 0.0602177341729066 0.609742559572421 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.772860683537698 0.132058090819728 3.22064246074135 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3643C>T rpoC_c.3643C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3651C>G rpoC_c.3651C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3654C>T rpoC_c.3654C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3663G>T rpoC_c.3663G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3666G>C rpoC_c.3666G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3675G>C rpoC_c.3675G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3690T>C rpoC_c.3690T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3690T>G rpoC_c.3690T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.369G>A rpoC_c.369G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3702C>T rpoC_c.3702C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 6 16809 30526 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999803484868334 0.999572318737888 0.999927879105266 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.302675154183274 0.00658396461982027 2.49513982006856 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 3 11501 23704 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.99987345509765 0.999630227076139 0.999973902638554 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.687012723531287 0.0130900577164196 8.55773267307823 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3711G>C rpoC_c.3711G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3714C>T rpoC_c.3714C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 7 18 16803 30514 0.000416418798334324 0.000167437820935922 0.000857792460925722 0.999410454605004 0.999068423526975 0.999650561796013 0.28 0.120716688504066 0.493876821806255 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.70621648250643 0.249257965337499 1.77250764259878 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 7 15 11495 23692 0.000608589810467744 0.000244718560881119 0.00125352303681455 0.999367275488252 0.9989566315242 0.999645827023281 0.318181818181818 0.138646521553797 0.54872442757377 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.961832680875743 0.331662885556543 2.50714900388285 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3720C>T rpoC_c.3720C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3723C>T rpoC_c.3723C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3729T>C rpoC_c.3729T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 4 16808 30528 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999868989912223 0.999664596427238 0.999964303043777 0.333333333333333 0.0432718682927417 0.777221904496487 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.90813898143741 0.0821237468238322 6.33854635470206 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 4 11500 23703 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999831273463534 0.999568049920357 0.99995402584539 0.333333333333333 0.0432718682927417 0.777221904496487 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.0305652173913 0.0931903474189042 7.19201282268065 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3735C>G rpoC_c.3735C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.341150751115529 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3738C>T rpoC_c.3738C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.373C>T rpoC_c.373C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3750A>G rpoC_c.3750A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3756G>C rpoC_c.3756G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3765C>T rpoC_c.3765C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 2 16808 30530 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999934494956111 0.999763393503742 0.99999206693684 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.8163969538315 0.131636449523742 25.0652602654423 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3769C>T rpoC_c.3769C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3771G>C rpoC_c.3771G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 1 16807 30531 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999967247478055 0.999817528289014 0.999999170778282 0.75 0.194120449683243 0.99369053679029 NA NA NA NA NA NA NA NA NA NA NA NA False False 5.44969358005592 0.437509494081317 285.652299683162 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3777G>T rpoC_c.3777G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3780C>T rpoC_c.3780C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 4 16809 30528 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999868989912223 0.999664596427238 0.999964303043777 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.454042477244333 0.00922341562850508 4.58878013974823 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 4 11501 23703 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999831273463534 0.999568049920357 0.99995402584539 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.515237805408225 0.0104655802548345 5.20753049950472 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3783T>C rpoC_c.3783T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3786C>T rpoC_c.3786C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 6 16809 30526 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999803484868334 0.999572318737888 0.999927879105266 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.302675154183274 0.00658396461982027 2.49513982006856 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 4 11501 23703 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999831273463534 0.999568049920357 0.99995402584539 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.515237805408225 0.0104655802548345 5.20753049950472 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3789T>C rpoC_c.3789T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.908144446427509 0.0153974005043644 17.4461131425891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3792C>A rpoC_c.3792C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3798C>G rpoC_c.3798C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3822C>G rpoC_c.3822C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 2 16808 30530 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999934494956111 0.999763393503742 0.99999206693684 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.8163969538315 0.131636449523742 25.0652602654423 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3825C>T rpoC_c.3825C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3828G>A rpoC_c.3828G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3837C>G rpoC_c.3837C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3837C>T rpoC_c.3837C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3840T>C rpoC_c.3840T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3843G>A rpoC_c.3843G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.9820231071276 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.24912710990902 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3846G>T rpoC_c.3846G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3849C>T rpoC_c.3849C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3852C>G rpoC_c.3852C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.908144446427509 0.0153974005043644 17.4461131425891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3852C>T rpoC_c.3852C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 4 16808 30528 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999868989912223 0.999664596427238 0.999964303043777 0.333333333333333 0.0432718682927417 0.777221904496487 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.90813898143741 0.0821237468238322 6.33854635470206 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 4 11500 23703 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999831273463534 0.999568049920357 0.99995402584539 0.333333333333333 0.0432718682927417 0.777221904496487 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.0305652173913 0.0931903474189042 7.19201282268065 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3858G>A rpoC_c.3858G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3861G>C rpoC_c.3861G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3864T>C rpoC_c.3864T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3867G>A rpoC_c.3867G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3870T>C rpoC_c.3870T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3873G>A rpoC_c.3873G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 16810 30526 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.54251408011679 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3885G>C rpoC_c.3885G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3894T>C rpoC_c.3894T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.-38C>T rpoC_c.-38C>T 2 upstream_gene_variant 763332 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC c.3900C>T rpoC_c.3900C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3912C>G rpoC_c.3912C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3915C>G rpoC_c.3915C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3919C>T rpoC_c.3919C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 5 16809 30527 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999836237390279 0.999617874429585 0.999946824656822 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.363222083407698 0.00768325476784986 3.24674897733262 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 3 11501 23704 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.99987345509765 0.999630227076139 0.999973902638554 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.687012723531287 0.0130900577164196 8.55773267307823 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3921G>A rpoC_c.3921G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3927C>T rpoC_c.3927C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.341150751115529 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3933C>T rpoC_c.3933C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 10 16 16800 30516 0.000594883997620464 0.000285305684944214 0.00109373983334496 0.999475959648893 0.999149130429312 0.999700436936355 0.384615384615384 0.20226024365502 0.594292464701408 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.13526785714285 0.460437500357612 2.66144980623778 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 12 11500 23695 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999493820390602 0.999115973206486 0.999738423129043 0.142857142857142 0.0177945154831915 0.428129160909698 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.343405797101449 0.0373242917489932 1.54295916091394 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3939C>T rpoC_c.3939C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 5 16809 30527 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999836237390279 0.999617874429585 0.999946824656822 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.363222083407698 0.00768325476784986 3.24674897733262 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 5 11501 23702 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999789091829417 0.999507879904061 0.999931515258336 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.412172854534388 0.00871781959321125 3.68423590106777 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3948C>A rpoC_c.3948C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.3948C>T rpoC_c.3948C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 3 16809 30529 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999901742434167 0.999712876815577 0.99997973646933 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.605409800305391 0.0115361654751757 7.54087213596152 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 3 11501 23704 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.99987345509765 0.999630227076139 0.999973902638554 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.687012723531287 0.0130900577164196 8.55773267307823 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.396T>G rpoC_c.396T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.39T>C rpoC_c.39T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.-39T>C rpoC_c.-39T>C 2 upstream_gene_variant 763331 1 1 1 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0465715996825058 Inf 0.355075831185839 416 4649 False False Inf 0.0465715996825058 Inf 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0528490600080728 Inf 0.32667783805277 340.5 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC c.402C>T rpoC_c.402C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.408C>T rpoC_c.408C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.-40G>A rpoC_c.-40G>A 2 upstream_gene_variant 763330 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC c.414G>A rpoC_c.414G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 10 16808 30522 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999672474780558 0.999397752220648 0.999842928110511 0.166666666666666 0.0208625254600923 0.484137748685967 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.363184198000951 0.0386890372209022 1.70456922948828 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 10 11500 23697 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999578183658835 0.999224402000993 0.999797704727851 0.166666666666666 0.0208625254600923 0.484137748685967 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.412121739130434 0.0439010319728098 1.93437051102569 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.-42_-41insT rpoC_c.-42_-41insT 2 upstream_gene_variant 763328 1 5 1 4 1 5 16809 30527 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999836237390279 0.999617874429585 0.999946824656822 0.166666666666666 0.00421074451448947 0.641234578997674 0.2 0.00505076337946806 0.716417936118089 0.166666666666666 0.00421074451448947 0.641234578997674 0.454027604259622 0.00922311366452189 4.58862982942286 0.661783643848212 928 4649 False False 0.363222083407698 0.00768325476784986 3.24674897733262 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 0.5 0.012579117093425 0.987420882906574 0.333333333333333 0.00840375865961264 0.905700675949754 2.06112511955482 0.02625506025566 161.594871509457 0.546656008695984 370.5 3890 False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC c.42T>G rpoC_c.42T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.435C>T rpoC_c.435C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.438T>C rpoC_c.438T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.456G>A rpoC_c.456G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.45T>G rpoC_c.45T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.477C>T rpoC_c.477C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.48C>T rpoC_c.48C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.498C>T rpoC_c.498C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.-5_-4insT rpoC_c.-5_-4insT 2 upstream_gene_variant 763365 NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3601 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3008 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC c.504C>G rpoC_c.504C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.517C>A rpoC_c.517C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 516 3490 16294 27042 0.0306960142772159 0.0281401644523371 0.0334158880979248 0.885693698414778 0.88207156478388 0.889242267001565 0.128806789815277 0.118582123814213 0.139576135840753 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.245377858075625 0.222825112130377 0.269793873893191 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 366 2774 11136 20933 0.0318205529473135 0.028688345408069 0.0351925560919936 0.882988146960813 0.878828350106724 0.887053796158191 0.11656050955414 0.105538316252913 0.128302447767681 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 1 0.24801439008776 0.221238421776556 0.277388184506605 NA NA NA NA NA NA 420 5) Not assoc w R Now listed Silent mutation no 0 +Rifampicin rpoC c.522G>A rpoC_c.522G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.75142405620251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.531G>C rpoC_c.531G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.546C>T rpoC_c.546C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 16810 30526 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.54251408011679 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.12235036001139 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.549G>A rpoC_c.549G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.54G>A rpoC_c.54G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.908144446427509 0.0153974005043644 17.4461131425891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.564C>T rpoC_c.564C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.573C>G rpoC_c.573C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.579G>A rpoC_c.579G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.582G>C rpoC_c.582G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.591T>C rpoC_c.591T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.591T>G rpoC_c.591T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.341150751115529 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.594C>T rpoC_c.594C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.597C>T rpoC_c.597C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.908144446427509 0.0153974005043644 17.4461131425891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.600C>T rpoC_c.600C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.618C>G rpoC_c.618C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.61A>C rpoC_c.61A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.627T>G rpoC_c.627T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.636G>C rpoC_c.636G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.648G>C rpoC_c.648G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.663C>T rpoC_c.663C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.66A>G rpoC_c.66A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.687G>C rpoC_c.687G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.693C>T rpoC_c.693C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.699G>A rpoC_c.699G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.-6A>C rpoC_c.-6A>C 2 upstream_gene_variant 763364 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC c.-6A>G rpoC_c.-6A>G 2 upstream_gene_variant 763364 NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3788 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3173 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC c.6C>A rpoC_c.6C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.6C>G rpoC_c.6C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.702G>A rpoC_c.702G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.75142405620251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.12235036001139 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.705C>A rpoC_c.705C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 11 16810 30521 0 0 0.000219421459229958 0.999639722258614 0.999355455254591 0.999820137367966 0 0 0.284914152918154 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.723522114724776 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 11 11502 23696 0 0 0.000320664925697395 0.999536002024718 0.999169931473241 0.999768351851939 0 0 0.284914152918154 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.821023972766749 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.717C>T rpoC_c.717C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 10 16807 30522 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999672474780558 0.999397752220648 0.999842928110511 0.23076923076923 0.0503810734911515 0.53813153923404 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.544808710656274 0.0963319696463728 2.11632117379279 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 9 11499 23698 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.999620365292951 0.999279457952852 0.99982639261309 0.25 0.0548606445279927 0.571858461878189 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.686958286227787 0.119601947020585 2.75338143066838 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.726C>A rpoC_c.726C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.726C>T rpoC_c.726C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.908144446427509 0.0153974005043644 17.4461131425891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.729A>G rpoC_c.729A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.6329128986197 0.189104318453829 214.057761575796 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.732C>G rpoC_c.732C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.735C>G rpoC_c.735C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.738C>T rpoC_c.738C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.741C>T rpoC_c.741C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.747C>T rpoC_c.747C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.75T>C rpoC_c.75T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.765C>G rpoC_c.765C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.771C>T rpoC_c.771C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.9820231071276 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.12235036001139 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.774G>C rpoC_c.774G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.783C>A rpoC_c.783C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.783C>T rpoC_c.783C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.75142405620251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.12235036001139 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.816C>A rpoC_c.816C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.819A>G rpoC_c.819A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.81G>A rpoC_c.81G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.837T>C rpoC_c.837T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.840C>T rpoC_c.840C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.843C>A rpoC_c.843C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.858G>A rpoC_c.858G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.867G>A rpoC_c.867G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.870T>G rpoC_c.870T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.873C>A rpoC_c.873C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.873C>T rpoC_c.873C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.879C>G rpoC_c.879C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.87A>G rpoC_c.87A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.908144446427509 0.0153974005043644 17.4461131425891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.882G>A rpoC_c.882G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.885G>T rpoC_c.885G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.886C>T rpoC_c.886C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.894G>A rpoC_c.894G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 20 93 16790 30439 0.00118976799524092 0.000726887900057249 0.00183690503094944 0.99695401545919 0.996269742886194 0.997540814793275 0.176991150442477 0.111592830446309 0.260027188942083 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.389876206395255 0.22763969827102 0.637352677598157 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 17 69 11485 23638 0.00147800382542166 0.000861220016155565 0.00236537605429428 0.997089467245961 0.996317958689543 0.997734747484473 0.197674418604651 0.119577735857902 0.297521445329609 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 0 0.507083593597193 0.279402246332599 0.872200429418929 NA NA NA NA NA NA 1 5) Not assoc w R Now listed Silent mutation no 0 +Rifampicin rpoC c.897T>G rpoC_c.897T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.909A>G rpoC_c.909A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.912G>A rpoC_c.912G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.921C>T rpoC_c.921C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.924G>C rpoC_c.924G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 15 26 16795 30506 0.000892325996430696 0.000499511372123772 0.00147132963433071 0.999148434429451 0.998752506314373 0.99944365605196 0.365853658536585 0.221227862061065 0.530637451967166 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.0479080312364 0.515828840784518 2.0542245831389 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 6 20 11496 23687 0.000521648408972352 0.000191459062774625 0.00113506056981396 0.99915636731767 0.998697376967606 0.99948461349205 0.23076923076923 0.0897401108845751 0.436475096941386 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.618136743215031 0.203079872025806 1.59649168970432 NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.933C>A rpoC_c.933C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.933C>G rpoC_c.933C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.939G>T rpoC_c.939G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.948C>T rpoC_c.948C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 16810 30526 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.54251408011679 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.12235036001139 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.954G>T rpoC_c.954G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.957G>C rpoC_c.957G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.960C>T rpoC_c.960C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.963G>A rpoC_c.963G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.75142405620251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.12235036001139 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.966G>A rpoC_c.966G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.969G>A rpoC_c.969G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.984G>T rpoC_c.984G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.993C>T rpoC_c.993C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.996C>T rpoC_c.996C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.99G>C rpoC_c.99G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC c.9C>T rpoC_c.9C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 7 16810 30525 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.26007067420399 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.24912710990902 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin rpoC p.Ala1037Val rpoC_p.Ala1037Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ala1044Gly rpoC_p.Ala1044Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3405 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2832 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ala1044Leu rpoC_p.Ala1044Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3512 4649 False False Inf 1.1990579265185 Inf 0 0 0.000219473678051534 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2931 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ala1044Val rpoC_p.Ala1044Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 75 3 72 15 78 16795 30454 0.000892325996430696 0.000499511372123772 0.00147132963433071 0.997445303288353 0.996812633501993 0.997980110410541 0.161290322580645 0.0931781799300409 0.252034262551079 0.04 0.0083261656660794 0.112476821760009 0.037037037037037 0.00770403726887334 0.104443712425679 0.0755532400516026 0.0151992054353689 0.229853802239658 8.91034418424281e-11 20 4649 True False 0.348707261776627 0.18624074682607 0.611261294682895 0.000178592689605905 3.6831620546597e-05 0.000521834036463332 0.997445303288353 0.996812633501993 0.997980110410541 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 46 2 44 9 48 11493 23659 0.000782472613458529 0.000357856744032263 0.00148485474620048 0.997975281562407 0.99731640289486 0.998506766700622 0.157894736842105 0.0748311692005124 0.278682630068729 0.0434782608695652 0.00530948284942996 0.148386775920115 0.04 0.00488143342616437 0.137137625603967 0.0935707901252145 0.0109848716565743 0.358800789075354 4.8054948425973e-06 27 3890 True False 0 0 0 0 0 0 0 0.38597950926651 0.166426281320239 0.795701457596786 0.000173988690735102 2.10715322043016e-05 0.000628364156401861 0.997975281562407 0.99731640289486 0.998506766700622 6 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ala1047Pro rpoC_p.Ala1047Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3758 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ala1144Ser rpoC_p.Ala1144Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3418 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2844 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ala1144Thr rpoC_p.Ala1144Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ala1184Val rpoC_p.Ala1184Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ala1188Ser rpoC_p.Ala1188Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 80.2910622977969 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ala1188Thr rpoC_p.Ala1188Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ala1195Val rpoC_p.Ala1195Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3633 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ala1201Ser rpoC_p.Ala1201Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ala1202Asp rpoC_p.Ala1202Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3773 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3161 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ala1213Glu rpoC_p.Ala1213Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 15 0 16795 30532 0.000892325996430696 0.000499511372123772 0.00147132963433071 1 0.999879187193184 1 1 0.781980639089466 1 NA NA NA NA NA NA NA NA NA NA 3499 4649 False False Inf 6.51893136980533 Inf 0 0 0.00021961740805081 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 10 0 11492 23707 0.000869414014953921 0.000416994043678715 0.001598300185227 1 0.999844409142079 1 1 0.691502892181239 1 NA NA NA NA NA NA NA NA NA NA 2918 3890 False False 0 0 0 0 0 0 0 Inf 4.62268854495848 Inf 0 0 0.000320943914091465 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ala1213Val rpoC_p.Ala1213Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3634 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3037 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ala1236Gly rpoC_p.Ala1236Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3378 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ala1271Ser rpoC_p.Ala1271Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3602 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3009 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ala1299Ser rpoC_p.Ala1299Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3805 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3190 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ala1299Val rpoC_p.Ala1299Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ala1300_Ala1303del rpoC_p.Ala1300_Ala1303del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ala1300Asn rpoC_p.Ala1300Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3550 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2965 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ala1300Val rpoC_p.Ala1300Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3569 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2982 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ala1304Val rpoC_p.Ala1304Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 70.7538526941519 1 1627.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 80.2773259044493 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ala153Thr rpoC_p.Ala153Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ala172Gly rpoC_p.Ala172Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ala172Val rpoC_p.Ala172Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 516 3493 16294 27039 0.0306960142772159 0.0281401644523371 0.0334158880979248 0.885595440848945 0.881971981256174 0.889145354304375 0.128710401596408 0.118492880785889 0.139472335849575 NA NA NA 0 0 0.00105552025993247 NA NA NA NA NA NA False True 0.245139914224985 0.222610067500811 0.269530877556637 0 0 0.000226369333114564 0.885595440848945 0.881971981256174 0.889145354304375 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 366 2777 11136 20930 0.0318205529473135 0.028688345408069 0.0351925560919936 0.882861602058463 0.878699902631495 0.886929185234466 0.116449252306713 0.105436972014379 0.128180798643384 NA NA NA 0 0 0.00132748665571148 NA NA NA NA NA NA False True 0 1 1 0 0 1 1 0.247710953894676 0.220967290784559 0.277045956279749 0 0 0.000331202275301108 0.882861602058463 0.878699902631495 0.886929185234466 420 Not assoc w R 5) Not assoc w R No change yes 1 +Rifampicin rpoC p.Ala174Val rpoC_p.Ala174Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3864 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3244 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ala17Thr rpoC_p.Ala17Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3441 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ala17Val rpoC_p.Ala17Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3735 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3126 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ala189Thr rpoC_p.Ala189Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ala191Ser rpoC_p.Ala191Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3678 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3075 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ala193Val rpoC_p.Ala193Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3620 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3024 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ala212Leu rpoC_p.Ala212Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3774 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3162 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ala212Thr rpoC_p.Ala212Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3831 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ala230Glu rpoC_p.Ala230Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3603 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3010 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ala230Val rpoC_p.Ala230Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 7 9 16803 30523 0.000416418798334324 0.000167437820935922 0.000857792460925722 0.999705227302502 0.999440503684993 0.999865202576615 0.4375 0.197534140532667 0.701223100916822 0 0 0.369416647552819 0 0 0.336267116879942 0 0 1.06433994642202 0.0571694575010849 170 4649 False False 1.41284955728805 0.447043788922069 4.26434344126608 0 0 0.000219512858481393 0.999705227302502 0.999440503684993 0.999865202576615 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 6 6 11496 23701 0.000521648408972352 0.000191459062774625 0.00113506056981396 0.9997469101953 0.999449212060655 0.99990711502044 0.5 0.210944638239296 0.789055361760703 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.75129947725298 0.186826886030767 203 3890 False False 0 0 0 0 0 0 0 2.0616736256089 0.551020849588822 7.71348034220691 0 0 0.000320832260499258 0.9997469101953 0.999449212060655 0.99990711502044 2 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ala316Thr rpoC_p.Ala316Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ala448Ser rpoC_p.Ala448Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3551 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ala466Val rpoC_p.Ala466Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3679 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3076 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ala492Pro rpoC_p.Ala492Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 10 0 16800 30532 0.000594883997620464 0.000285305684944214 0.00109373983334496 1 0.999879187193184 1 1 0.691502892181239 1 NA NA NA NA NA NA NA NA NA NA 3850 4649 False False Inf 4.07313735951873 Inf 0 0 0.000219552052902727 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 6 0 11496 23707 0.000521648408972352 0.000191459062774625 0.00113506056981396 1 0.999844409142079 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 3231 3890 False False 0 0 0 0 0 0 0 Inf 2.42738974088595 Inf 0 0 0.000320832260499258 1 0.999844409142079 1 1 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ala492Val rpoC_p.Ala492Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 22 0 16788 30532 0.00130874479476502 0.000820359439669085 0.00198078881845282 1 0.999879187193184 1 1 0.845627487184425 1 NA NA NA NA NA NA NA NA NA NA 3697 4649 False False Inf 9.95930561201006 Inf 0 0 0.000219708970652805 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 12 0 11490 23707 0.0010432968179447 0.000539199208333142 0.00182171963730016 1 0.999844409142079 1 1 0.735351530602948 1 NA NA NA NA NA NA NA NA NA NA 3094 3890 False False 0 0 0 0 0 0 0 Inf 5.7314630344545 Inf 0 0 0.000320999770035263 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ala521Asp rpoC_p.Ala521Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 50 0 16760 30532 0.00297441998810232 0.0022084533311552 0.00391954445665535 1 0.999879187193184 1 1 0.928878263535802 1 NA NA NA NA NA NA NA NA NA NA 3698 4649 False False Inf 23.7718305112658 Inf 0 0 0.00022007598581935 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 41 0 11461 23707 0.00356459746131107 0.00255919435806085 0.00483270406615093 1 0.999844409142079 1 1 0.913956163705971 1 NA NA NA NA NA NA NA NA NA NA 3095 3890 False False 0 0 0 0 0 0 0 Inf 21.965266136217 Inf 0 0 0.000321811871535852 1 0.999844409142079 1 12 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ala521Thr rpoC_p.Ala521Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3736 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3127 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ala521Val rpoC_p.Ala521Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 70.7668929171829 1 1627.5 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 0 0 0.000219447565534303 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 80.2980353694986 1 1214.5 3890 False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 0 0 0.000320720684566658 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ala542Gly rpoC_p.Ala542Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3585 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ala553Val rpoC_p.Ala553Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ala575Val rpoC_p.Ala575Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3865 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ala618Val rpoC_p.Ala618Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ala621Thr rpoC_p.Ala621Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 70 435 16740 30097 0.00416418798334324 0.00324758416539656 0.00525831335367222 0.985752652954277 0.984359768437886 0.987051952060873 0.138613861386138 0.109675593955578 0.171859119352509 NA NA NA 0 0 0.00844432732903666 NA NA NA NA NA NA False True 0.289318721762177 0.221327658163444 0.373428638015716 0 0 0.000220338891122086 0.985752652954277 0.984359768437886 0.987051952060873 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 66 379 11436 23328 0.00573813249869587 0.00444056862656701 0.00729460434309714 0.984013160669844 0.982334804104595 0.985571285237592 0.148314606741573 0.116600108619282 0.184790552709369 NA NA NA 0 0 0.0096859769723856 NA NA NA NA NA NA False True 0 1 1 0 0 1 1 0.355228731931104 0.268991486119109 0.462905231104275 0 0 0.000322515264267885 0.984013160669844 0.982334804104595 0.985571285237592 27 Not assoc w R 5) Not assoc w R No change yes 1 +Rifampicin rpoC p.Ala621Val rpoC_p.Ala621Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3513 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2932 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ala648Asp rpoC_p.Ala648Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3406 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2833 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ala648Thr rpoC_p.Ala648Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ala661Thr rpoC_p.Ala661Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ala694Ser rpoC_p.Ala694Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3699 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3096 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ala694Thr rpoC_p.Ala694Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3442 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2865 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ala695Val rpoC_p.Ala695Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3806 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3191 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ala701Val rpoC_p.Ala701Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3552 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2966 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ala710Gly rpoC_p.Ala710Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3723 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ala710Val rpoC_p.Ala710Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3455 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ala734Gly rpoC_p.Ala734Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3379 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2810 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ala734Thr rpoC_p.Ala734Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3456 4649 False False Inf 1.1990579265185 Inf 0 0 0.000219473678051534 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 11498 23707 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 1 0.999844409142079 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2877 3890 False False 0 0 0 0 0 0 0 Inf 1.3608069907404 Inf 0 0 0.000320776462830572 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ala734Val rpoC_p.Ala734Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 20 0 16790 30532 0.00118976799524092 0.000726887900057249 0.00183690503094944 1 0.999879187193184 1 1 0.831566529016914 1 NA NA NA NA NA NA NA NA NA NA 3470 4649 False False Inf 8.97808458256773 Inf 0 0 0.000219682802119661 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 8 0 11494 23707 0.000695531211963136 0.000300327312744212 0.00137001129783907 1 0.999844409142079 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 2889 3890 False False 0 0 0 0 0 0 0 Inf 3.51981666109462 Inf 0 0 0.000320888077582845 1 0.999844409142079 1 4 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ala753Glu rpoC_p.Ala753Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3586 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2997 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ala764Thr rpoC_p.Ala764Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3553 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ala773Glu rpoC_p.Ala773Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3570 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2983 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ala788Val rpoC_p.Ala788Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3514 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2933 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ala818Val rpoC_p.Ala818Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 9 0 16801 30532 0.000535395597858417 0.000244845253515427 0.00101610321951737 1 0.999879187193184 1 1 0.663732883120057 1 NA NA NA NA NA NA NA NA NA NA 3724 4649 False False Inf 3.58631764003717 Inf 0 0 0.000219538986540545 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 8 0 11494 23707 0.000695531211963136 0.000300327312744212 0.00137001129783907 1 0.999844409142079 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 3118 3890 False False 0 0 0 0 0 0 0 Inf 3.51981666109462 Inf 0 0 0.000320888077582845 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ala85Ser rpoC_p.Ala85Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3635 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3038 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ala85Thr rpoC_p.Ala85Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3407 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2834 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ala861Ser rpoC_p.Ala861Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3486 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2905 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 2 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ala861Thr rpoC_p.Ala861Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3660 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ala902Thr rpoC_p.Ala902Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3636 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ala905Thr rpoC_p.Ala905Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3457 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ala929Gly rpoC_p.Ala929Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ala969Asp rpoC_p.Ala969Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3604 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3011 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ala994Thr rpoC_p.Ala994Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Arg1030Trp rpoC_p.Arg1030Trp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3866 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Arg1052Gly rpoC_p.Arg1052Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Arg1083Gln rpoC_p.Arg1083Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3458 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2878 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Arg1083Gly rpoC_p.Arg1083Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3661 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Arg1083Leu rpoC_p.Arg1083Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3487 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Arg1085_Leu1086insGlnArgGlnArg rpoC_p.Arg1085_Leu1086insGlnArgGlnArg 2 inframe_insertion (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3637 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3039 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Arg1163Cys rpoC_p.Arg1163Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 1 5 16809 30527 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999836237390279 0.999617874429585 0.999946824656822 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.98214103142536 0.168452649138924 269 4649 False False 0.363222083407698 0.00768325476784986 3.24674897733262 0 0 0.000219434511605659 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 1 5 11501 23702 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999789091829417 0.999507879904061 0.999931515258336 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.521823750104981 0 0 0.521823750104981 0 0 2.24932299250856 0.180435646558949 191.5 3890 False False 0 0 0 0 0 0 0 0.412172854534388 0.00871781959321125 3.68423590106777 0 0 0.000320692802708327 0.999789091829417 0.999507879904061 0.999931515258336 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Arg1163His rpoC_p.Arg1163His 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Arg1163Leu rpoC_p.Arg1163Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 3 1 16807 30531 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999967247478055 0.999817528289014 0.999999170778282 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 3408 4649 False False 5.44969358005592 0.437509494081317 285.652299683162 0 0 0.000219460621016169 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2835 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Arg1191Cys rpoC_p.Arg1191Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3700 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3097 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Arg1191His rpoC_p.Arg1191His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Arg1192Gln rpoC_p.Arg1192Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Arg1192Leu rpoC_p.Arg1192Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Arg11His rpoC_p.Arg11His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3662 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Arg11Ser rpoC_p.Arg11Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Arg1279Ser rpoC_p.Arg1279Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Arg159His rpoC_p.Arg159His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3409 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2836 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Arg173Gln rpoC_p.Arg173Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Arg203Cys rpoC_p.Arg203Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Arg206Cys rpoC_p.Arg206Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Arg211His rpoC_p.Arg211His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Arg242Cys rpoC_p.Arg242Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3867 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3245 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Arg247Cys rpoC_p.Arg247Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Arg247His rpoC_p.Arg247His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 3 1 16807 30531 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999967247478055 0.999817528289014 0.999999170778282 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 3680 4649 False False 5.44969358005592 0.437509494081317 285.652299683162 0 0 0.000219460621016169 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 3077 3890 False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 0 0 0.000320720684566658 0.999957818365883 0.999765001636458 0.999998932054057 8 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Arg278Gln rpoC_p.Arg278Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3737 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3128 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Arg282Gln rpoC_p.Arg282Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3443 4649 False False 0.908144446427509 0.0153974005043644 17.4461131425891 0 0 0.000219434511605659 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2866 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Arg282Leu rpoC_p.Arg282Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3488 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2906 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Arg282Lys rpoC_p.Arg282Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3459 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2879 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Arg346Trp rpoC_p.Arg346Trp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3554 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2967 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Arg397Leu rpoC_p.Arg397Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Arg459Trp rpoC_p.Arg459Trp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3571 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2984 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Arg474Ser rpoC_p.Arg474Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Arg478Cys rpoC_p.Arg478Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Arg478His rpoC_p.Arg478His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0465743703410529 Inf 0.355062208233877 391.5 4649 False False Inf 0.341150751115529 Inf 5.94919388422868e-05 1.50620434989522e-06 0.000331422795737767 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.052853655209362 Inf 0.326658713928652 320 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 8.69489609599165e-05 2.20135467503192e-06 0.000484352330576856 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Arg506Gln rpoC_p.Arg506Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Arg556Cys rpoC_p.Arg556Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 8 0 16802 30532 0.000475907198096371 0.00020548462525215 0.000937510381255989 1 0.999879187193184 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 3621 4649 False False Inf 3.10133467016734 Inf 0 0 0.000219525921733526 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 5 0 11497 23707 0.00043470700747696 0.000141162766530747 0.00101416710312943 1 0.999844409142079 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 3025 3890 False False 0 0 0 0 0 0 0 Inf 1.88913119689894 Inf 0 0 0.000320804359238686 1 0.999844409142079 1 6 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Arg556His rpoC_p.Arg556His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Arg556Ser rpoC_p.Arg556Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Arg572Cys rpoC_p.Arg572Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3868 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3246 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Arg572His rpoC_p.Arg572His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 13 0 16797 30532 0.000773349196906603 0.000411838091387593 0.00132208760075144 1 0.999879187193184 1 1 0.752947361999529 1 NA NA NA NA NA NA NA NA NA NA 3605 4649 False False Inf 5.53887003766597 Inf 0 0 0.000219591261323031 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 11 0 11491 23707 0.000956355416449313 0.000477502787107626 0.00171053820723243 1 0.999844409142079 1 1 0.715085847081845 1 NA NA NA NA NA NA NA NA NA NA 3012 3890 False False 0 0 0 0 0 0 0 Inf 5.1761760609822 Inf 0 0 0.000320971839633333 1 0.999844409142079 1 3 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Arg572Ser rpoC_p.Arg572Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3410 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2837 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Arg624His rpoC_p.Arg624His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3419 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2845 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Arg630Gln rpoC_p.Arg630Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Arg641Gln rpoC_p.Arg641Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Arg641Trp rpoC_p.Arg641Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 12 0 12 0 14 16810 30518 0 0 0.000219421459229958 0.999541464692781 0.999230775228684 0.999749292529582 0 0 0.231635761650116 0 0 0.264648469397051 0 0 0.231635761650116 0 0 0.653484438411549 0.00613701803106246 90 4649 False False 0 0 0.547412779991011 0 0 0.000219421459229958 0.999541464692781 0.999230775228684 0.999749292529582 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 12 0 12 0 14 11502 23693 0 0 0.000320664925697395 0.999409457122369 0.999009367705732 0.999677108302285 0 0 0.231635761650116 0 0 0.264648469397051 0 0 0.231635761650116 0 0 0.741497481793335 0.0119666412880409 81 3890 False False 0 0 0 0 0 0 0 0 0 0.621144612257265 0 0 0.000320664925697395 0.999409457122369 0.999009367705732 0.999677108302285 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Arg69Pro rpoC_p.Arg69Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 77 16809 30455 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.997478055810297 0.996848995832452 0.998009224190949 0.0128205128205128 0.000324534609097223 0.0693727407856049 NA NA NA 0 0 0.046778068160404 NA NA NA NA NA NA False True 0.023530220745998 0.000592812149264002 0.135101733218843 0 0 0.000219434511605659 0.997478055810297 0.996848995832452 0.998009224190949 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 1 72 11501 23635 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.996962922343611 0.996176810236695 0.997622938090518 0.0136986301369863 0.000346759152599127 0.0739763231783441 NA NA NA 0 0 0.0499440837058546 NA NA NA NA NA NA False True 1 1 1 0 0 1 0 0.0285422040595503 0.000717311456204906 0.16422656590577 0 0 0.000320692802708327 0.996962922343611 0.996176810236695 0.997622938090518 5 Not assoc w R 5) Not assoc w R No change yes 1 +Rifampicin rpoC p.Arg741Cys rpoC_p.Arg741Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 2 5 16808 30527 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999836237390279 0.999617874429585 0.999946824656822 0.285714285714285 0.0366925661760855 0.709579136262657 0 0 0.707598226178713 0 0 0.521823750104981 0 0 4.39578789664168 0.556927817140462 802.5 4649 False False 0.726487386958591 0.069161301215026 4.43811993507661 0 0 0.000219447565534303 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 5 11501 23702 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999789091829417 0.999507879904061 0.999931515258336 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.707598226178713 0 0 0.521823750104981 0 0 4.98826115735512 0.555670231197011 458.5 3890 False False 0 0 0 0 0 0 0 0.412172854534388 0.00871781959321125 3.68423590106777 0 0 0.000320692802708327 0.999789091829417 0.999507879904061 0.999931515258336 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Arg741His rpoC_p.Arg741His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3738 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3129 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Arg741Ser rpoC_p.Arg741Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 1 4 61 4 16749 30528 0.00362879238548483 0.00277684133202919 0.00465892783951422 0.999868989912223 0.999664596427238 0.999964303043777 0.938461538461538 0.849866599329491 0.982980028816979 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 0.45566899516389 0.00925643664588662 4.60522013093288 0.662060122124895 931 4649 False False 27.7958087049973 10.3134395369891 105.314110318743 5.97014925373134e-05 1.51150978210315e-06 0.000332590036127908 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 22 1 11480 23706 0.00191271083289862 0.00119906180010764 0.00289444346770694 0.999957818365883 0.999765001636458 0.999998932054057 0.956521739130434 0.780513392546519 0.998899831369558 0 0 0.975 0 0 0.975 0 0 80.4377515952779 1 1214.5 3890 False False 0 0 0 0 0 0 0 45.4296167247386 7.34012896092651 1857.61725292881 0 0 0.000321279341637369 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Arg752His rpoC_p.Arg752His 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Arg762Cys rpoC_p.Arg762Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3638 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Arg762His rpoC_p.Arg762His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Arg770His rpoC_p.Arg770His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 16 0 16794 30532 0.000951814396192742 0.000544138942285324 0.00154522796648703 1 0.999879187193184 1 1 0.794092785792177 1 NA NA NA NA NA NA NA NA NA NA 3444 4649 False False Inf 7.00986495552168 Inf 0 0 0.000219630483749807 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 13 0 11489 23707 0.00113023821944009 0.000601937155487611 0.00193196626494298 1 0.999844409142079 1 1 0.752947361999529 1 NA NA NA NA NA NA NA NA NA NA 2867 3890 False False 0 0 0 0 0 0 0 Inf 6.28688570681876 Inf 0 0 0.000321027705298525 1 0.999844409142079 1 9 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Arg834Ser rpoC_p.Arg834Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3471 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2890 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Arg912His rpoC_p.Arg912His 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 6 16810 30526 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 0 0 0.4592581264399 0 0 0.841886116991581 0 0 0.4592581264399 0 0 9.66933336511864 0.541978962766188 450.5 4649 False False 0 0 1.54251408011679 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2907 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 2 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Arg963Cys rpoC_p.Arg963Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Arg981Gly rpoC_p.Arg981Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3357 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2790 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Arg981Leu rpoC_p.Arg981Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3445 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2868 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Arg981Pro rpoC_p.Arg981Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3500 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2919 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Arg981Ser rpoC_p.Arg981Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3394 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2824 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asn1239Asp rpoC_p.Asn1239Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Asn1246Asp rpoC_p.Asn1246Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Asn1246Gln rpoC_p.Asn1246Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3446 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2869 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asn1251Asp rpoC_p.Asn1251Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3534 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asn1251Ser rpoC_p.Asn1251Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3775 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asn239Ser rpoC_p.Asn239Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3411 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2838 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asn239Thr rpoC_p.Asn239Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3807 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3192 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asn267Ser rpoC_p.Asn267Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3663 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3059 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asn416Ser rpoC_p.Asn416Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 62 0 16748 30532 0.00368828078524687 0.00282891765203409 0.00472574967930281 1 0.999879187193184 1 1 0.942237365570709 1 1 0.025 1 1 0.025 1 Inf 0.0467412152968681 Inf 0.354243776569869 375 4649 False False Inf 29.7328210709735 Inf 5.97050570183294e-05 1.51160002681267e-06 0.000332609890725005 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 43 0 11459 23707 0.00373848026430186 0.00270683805490488 0.00503244064340606 1 0.999844409142079 1 1 0.917788878845861 1 1 0.025 1 1 0.025 1 Inf 0.0530427489429278 Inf 0.325873688401057 301 3890 False False 0 0 0 0 0 0 0 Inf 23.0892274203818 Inf 8.72600349040139e-05 2.20923036804925e-06 0.000486084833603693 1 0.999844409142079 1 33 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asn416Thr rpoC_p.Asn416Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 14 0 16796 30532 0.000832837596668649 0.000455392489979272 0.00139696554892221 1 0.999879187193184 1 1 0.768364238349883 1 NA NA NA NA NA NA NA NA NA NA 3832 4649 False False Inf 6.02871753174659 Inf 0 0 0.000219604333908644 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 11 0 11491 23707 0.000956355416449313 0.000477502787107626 0.00171053820723243 1 0.999844409142079 1 1 0.715085847081845 1 NA NA NA NA NA NA NA NA NA NA 3214 3890 False False 0 0 0 0 0 0 0 Inf 5.1761760609822 Inf 0 0 0.000320971839633333 1 0.999844409142079 1 2 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asn468Thr rpoC_p.Asn468Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3823 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asn564Asp rpoC_p.Asn564Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3851 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3232 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asn698His rpoC_p.Asn698His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 29 0 16781 30532 0.00172516359309934 0.00115566411224569 0.00247669038907857 1 0.999879187193184 1 1 0.880555130930497 1 NA NA NA NA NA NA NA NA NA NA 3852 4649 False False Inf 13.4077314477923 Inf 0 0 0.000219800609634964 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 25 0 11477 23707 0.0021735350373848 0.00140707589428017 0.00320690572089761 1 0.999844409142079 1 1 0.862814828469287 1 NA NA NA NA NA NA NA NA NA NA 3233 3890 False False 0 0 0 0 0 0 0 Inf 12.9870104436498 Inf 0 0 0.000321363308103974 1 0.999844409142079 1 15 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asn698Leu rpoC_p.Asn698Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3749 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3139 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asn698Lys rpoC_p.Asn698Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 43 0 16767 30532 0.00255800118976799 0.00185183780155513 0.00344408115441007 1 0.999879187193184 1 1 0.917788878845861 1 NA NA NA NA NA NA NA NA NA NA 3587 4649 False False Inf 20.3218622729967 Inf 0 0 0.000219984117122384 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 30 0 11472 23707 0.00260824204486176 0.00176044063976377 0.00372135102988799 1 0.999844409142079 1 1 0.884296691777972 1 NA NA NA NA NA NA NA NA NA NA 2998 3890 False False 0 0 0 0 0 0 0 Inf 15.7828256832504 Inf 0 0 0.000321503349789329 1 0.999844409142079 1 11 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asn698Ser rpoC_p.Asn698Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 178 0 16632 30532 0.0105889351576442 0.00909701142081063 0.0122536262945968 1 0.999879187193184 1 1 0.979489225285489 1 NA NA NA NA NA NA NA NA NA NA 3489 4649 False False Inf 87.8074996238862 Inf 0 0 0.000221769504479867 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 127 0 11375 23707 0.0110415579899147 0.00921293021365061 0.0131235650208128 1 0.999844409142079 1 1 0.971371493865612 1 NA NA NA NA NA NA NA NA NA NA 2908 3890 False False 0 0 0 0 0 0 0 Inf 70.6998854940444 Inf 0 0 0.00032424451624814 1 0.999844409142079 1 18 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asn698Thr rpoC_p.Asn698Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3515 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2934 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asn766Ser rpoC_p.Asn766Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 70.7603724184383 1 1627.5 4649 False False 0.908144446427509 0.0153974005043644 17.4461131425891 0 0 0.000219434511605659 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asn771Asp rpoC_p.Asn771Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 11 1 16799 30531 0.00065437239738251 0.000326704163498642 0.00117055062018267 0.999967247478055 0.999817528289014 0.999999170778282 0.916666666666666 0.615203834849055 0.997892406768139 NA NA NA 0 0 0.975 NA NA NA NA 3853 4649 False False 19.9917256979582 2.90506952047996 857.005572217769 0 0 0.000219565120820351 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 8 1 11494 23706 0.000695531211963136 0.000300327312744212 0.00137001129783907 0.999957818365883 0.999765001636458 0.999998932054057 0.888888888888888 0.517503485082663 0.9971908632534 NA NA NA 0 0 0.975 NA NA NA NA 3234 3890 False False 0 0 0 0 0 0 0 16.4997389942578 2.21148555913028 729.537626249525 0 0 0.000320888077582845 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asn826Lys rpoC_p.Asn826Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3869 4649 False False Inf 1.1990579265185 Inf 0 0 0.000219473678051534 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3247 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 3 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asn826Thr rpoC_p.Asn826Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 50 0 16760 30532 0.00297441998810232 0.0022084533311552 0.00391954445665535 1 0.999879187193184 1 1 0.928878263535802 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.342128042746276 Inf 0.12560960540241 219 4649 False False Inf 23.7718305112658 Inf 0.000119317503877818 1.4450229911782e-05 0.000430948681172172 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 48 0 11454 23707 0.00417318727177882 0.00307853380895242 0.00552927675802278 1 0.999844409142079 1 1 0.926027214652719 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.388645122633668 Inf 0.106137439963409 146 3890 False False 0 0 0 0 0 0 0 Inf 25.900627754994 Inf 0.000174581005586592 2.11432690180535e-05 0.00063050282730645 1 0.999844409142079 1 6 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asp1093Glu rpoC_p.Asp1093Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3759 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3147 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Asp1103_His1104dup rpoC_p.Asp1103_His1104dup 2 inframe_insertion (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3739 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asp1103Gly rpoC_p.Asp1103Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3639 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asp1117Gly rpoC_p.Asp1117Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3854 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3235 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 2 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asp1117His rpoC_p.Asp1117His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3358 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2791 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asp1169Glu rpoC_p.Asp1169Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3472 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Asp1218Ala rpoC_p.Asp1218Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3760 4649 False False Inf 1.1990579265185 Inf 0 0 0.000219473678051534 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 11498 23707 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 1 0.999844409142079 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3148 3890 False False 0 0 0 0 0 0 0 Inf 1.3608069907404 Inf 0 0 0.000320776462830572 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asp1218Gly rpoC_p.Asp1218Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3395 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asp1243His rpoC_p.Asp1243His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3501 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2920 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asp180Ala rpoC_p.Asp180Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3359 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2792 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asp192Gly rpoC_p.Asp192Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Asp19Ala rpoC_p.Asp19Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3420 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2846 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Asp19Asn rpoC_p.Asp19Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3412 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2839 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asp217Glu rpoC_p.Asp217Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asp221Asn rpoC_p.Asp221Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3701 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3098 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Asp271Asn rpoC_p.Asp271Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Asp271Glu rpoC_p.Asp271Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3606 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asp271Gly rpoC_p.Asp271Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 25 242 16785 30290 0.00148720999405116 0.000962667916776425 0.00219463783814356 0.992073889689506 0.991014594768357 0.993037877003748 0.0936329588014981 0.0615136955518493 0.135115104898001 NA NA NA 0 0 0.0151277124534154 NA NA NA NA NA NA False True 0.18642432120375 0.118262085801721 0.282079015567778 0 0 0.000219748235144057 0.992073889689506 0.991014594768357 0.993037877003748 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 23 226 11479 23481 0.00199965223439401 0.00126801715451488 0.0029989585229059 0.990466950689669 0.989146914492968 0.991664552362552 0.0923694779116465 0.0594579401434507 0.135373694296529 NA NA NA 0 0 0.0161899856912104 NA NA NA NA NA NA False True 0 1 1 0 0 1 1 0.208176608766913 0.129256560153675 0.320504558292206 0 0 0.000321307325583828 0.990466950689669 0.989146914492968 0.991664552362552 14 Not assoc w R 5) Not assoc w R No change yes 1 +Rifampicin rpoC p.Asp279Gly rpoC_p.Asp279Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 2 2 16808 30530 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999934494956111 0.999763393503742 0.99999206693684 0.5 0.067585986488543 0.932414013511457 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.67174719181657 0.54201215115422 740.5 4649 False False 1.8163969538315 0.131636449523742 25.0652602654423 0 0 0.000219447565534303 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2793 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 7 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Asp331Ala rpoC_p.Asp331Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3824 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3207 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Asp331Val rpoC_p.Asp331Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3808 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3193 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asp339Glu rpoC_p.Asp339Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3833 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3215 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asp404Ala rpoC_p.Asp404Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 6 0 16804 30532 0.000356930398572278 0.000130998068917797 0.000776724091447791 1 0.999879187193184 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 3776 4649 False False Inf 2.13890645017026 Inf 0 0 0.000219499796783869 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3163 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asp44Glu rpoC_p.Asp44Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 11 3 8 34 10 16776 30522 0.00202260559190957 0.00140110733425029 0.00282525244033458 0.999672474780558 0.999397752220648 0.999842928110511 0.772727272727272 0.62155705243448 0.885266486061404 0.272727272727272 0.0602177341729066 0.609742559572421 0.23076923076923 0.0503810734911515 0.53813153923404 0.682269313304721 0.116564475833961 2.84316465613461 0.756591751649409 933 4649 False False 6.18590844062947 2.98710526331236 14.0415204984237 0.000178794922224208 3.68733292061599e-05 0.000522424842988854 0.999672474780558 0.999397752220648 0.999842928110511 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 3 8 22 10 11480 23697 0.00191271083289862 0.00119906180010764 0.00289444346770694 0.999578183658835 0.999224402000993 0.999797704727851 0.6875 0.49992241836783 0.838815275911799 0.272727272727272 0.0602177341729066 0.609742559572421 0.23076923076923 0.0503810734911515 0.53813153923404 0.774074477351916 0.132265733793065 3.22568895548599 1 1214.5 3890 False False 0 0 0 0 0 0 0 4.54123693379791 2.06264750707361 10.7459869245707 0.00026125576939824 5.38804613640786e-05 0.000763308512931556 0.999578183658835 0.999224402000993 0.999797704727851 8 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Asp44Gly rpoC_p.Asp44Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asp462Gly rpoC_p.Asp462Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Asp485Asn rpoC_p.Asp485Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 113 0 16697 30532 0.00672218917311124 0.00554315165625547 0.00807642421530563 1 0.999879187193184 1 1 0.96788214425426 1 NA NA NA NA NA NA NA NA NA NA 3870 4649 False False Inf 55.0070767424024 Inf 0 0 0.000220906270037165 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 92 0 11410 23707 0.00799860893757607 0.00645273861683653 0.00980068947434154 1 0.999844409142079 1 1 0.960696712260482 1 NA NA NA NA NA NA NA NA NA NA 3248 3890 False False 0 0 0 0 0 0 0 Inf 50.8246759462726 Inf 0 0 0.000323250061939669 1 0.999844409142079 1 34 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asp485His rpoC_p.Asp485His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 9 0 16801 30532 0.000535395597858417 0.000244845253515427 0.00101610321951737 1 0.999879187193184 1 1 0.663732883120057 1 NA NA NA NA NA NA NA NA NA NA 3460 4649 False False Inf 3.58631764003717 Inf 0 0 0.000219538986540545 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 7 0 11495 23707 0.000608589810467744 0.000244718560881119 0.00125352303681455 1 0.999844409142079 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 2880 3890 False False 0 0 0 0 0 0 0 Inf 2.97179240572548 Inf 0 0 0.000320860166613556 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asp485Tyr rpoC_p.Asp485Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 200 0 16610 30532 0.0118976799524092 0.0103137472207899 0.0136536835643474 1 0.999879187193184 1 1 0.981724659644863 1 NA NA NA NA NA NA NA NA NA NA 3473 4649 False False Inf 98.9294078519361 Inf 0 0 0.000222063206306668 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 145 0 11357 23707 0.0126065032168318 0.0106481831982627 0.0148169348501032 1 0.999844409142079 1 1 0.974880335868198 1 NA NA NA NA NA NA NA NA NA NA 2891 3890 False False 0 0 0 0 0 0 0 Inf 81.1773718615143 Inf 0 0 0.000324758336225243 1 0.999844409142079 1 39 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asp485Val rpoC_p.Asp485Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3421 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2847 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asp57Ala rpoC_p.Asp57Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3461 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2881 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asp595Ala rpoC_p.Asp595Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 7 16810 30525 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 0 0 0.409616397225003 0 0 0.707598226178713 0 0 0.409616397225003 0 0 4.39497674197459 0.556933152242376 924 4649 False False 0 0 1.26007067420399 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Asp660Asn rpoC_p.Asp660Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3740 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3130 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 2 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Asp714Asn rpoC_p.Asp714Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3725 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3119 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asp714Glu rpoC_p.Asp714Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 5 0 16805 30532 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 1 0.999879187193184 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 3777 4649 False False Inf 1.66460481015123 Inf 0 0 0.000219486736640675 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 11498 23707 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 1 0.999844409142079 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3164 3890 False False 0 0 0 0 0 0 0 Inf 1.3608069907404 Inf 0 0 0.000320776462830572 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asp735Asn rpoC_p.Asp735Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3681 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3078 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asp735Glu rpoC_p.Asp735Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 8 0 16802 30532 0.000475907198096371 0.00020548462525215 0.000937510381255989 1 0.999879187193184 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 3588 4649 False False Inf 3.10133467016734 Inf 0 0 0.000219525921733526 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 8 0 11494 23707 0.000695531211963136 0.000300327312744212 0.00137001129783907 1 0.999844409142079 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 2999 3890 False False 0 0 0 0 0 0 0 Inf 3.51981666109462 Inf 0 0 0.000320888077582845 1 0.999844409142079 1 6 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asp747Ala rpoC_p.Asp747Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 22 0 16788 30532 0.00130874479476502 0.000820359439669085 0.00198078881845282 1 0.999879187193184 1 1 0.845627487184425 1 NA NA NA NA NA NA NA NA NA NA 3702 4649 False False Inf 9.95930561201006 Inf 0 0 0.000219708970652805 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 15 0 11487 23707 0.00130412102243088 0.000730084557867185 0.00215003854003137 1 0.999844409142079 1 1 0.781980639089466 1 NA NA NA NA NA NA NA NA NA NA 3099 3890 False False 0 0 0 0 0 0 0 Inf 7.40065484717093 Inf 0 0 0.000321083590414119 1 0.999844409142079 1 5 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asp747Asn rpoC_p.Asp747Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3750 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3140 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 2 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asp747Glu rpoC_p.Asp747Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3751 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3141 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asp747Gly rpoC_p.Asp747Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 8 0 16802 30532 0.000475907198096371 0.00020548462525215 0.000937510381255989 1 0.999879187193184 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 3752 4649 False False Inf 3.10133467016734 Inf 0 0 0.000219525921733526 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 7 0 11495 23707 0.000608589810467744 0.000244718560881119 0.00125352303681455 1 0.999844409142079 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 3142 3890 False False 0 0 0 0 0 0 0 Inf 2.97179240572548 Inf 0 0 0.000320860166613556 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asp747His rpoC_p.Asp747His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3703 4649 False False Inf 1.1990579265185 Inf 0 0 0.000219473678051534 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3100 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asp754Ala rpoC_p.Asp754Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Asp768Tyr rpoC_p.Asp768Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3789 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3174 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asp783Glu rpoC_p.Asp783Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3516 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2935 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asp795Ala rpoC_p.Asp795Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3790 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3175 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asp795Glu rpoC_p.Asp795Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Asp795Gly rpoC_p.Asp795Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Asp795Tyr rpoC_p.Asp795Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Asp796Gly rpoC_p.Asp796Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Asp869Glu rpoC_p.Asp869Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 5 0 16805 30532 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 1 0.999879187193184 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 3517 4649 False False Inf 1.66460481015123 Inf 0 0 0.000219486736640675 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 11498 23707 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 1 0.999844409142079 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2936 3890 False False 0 0 0 0 0 0 0 Inf 1.3608069907404 Inf 0 0 0.000320776462830572 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asp890Glu rpoC_p.Asp890Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Asp8His rpoC_p.Asp8His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3502 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2921 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asp907Gly rpoC_p.Asp907Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Asp943Asn rpoC_p.Asp943Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3360 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2794 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asp943Glu rpoC_p.Asp943Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3555 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2968 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asp943Gly rpoC_p.Asp943Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3834 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3216 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 3 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asp943His rpoC_p.Asp943His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3726 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Asp950His rpoC_p.Asp950His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3589 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gln1084_Arg1085dup rpoC_p.Gln1084_Arg1085dup 2 inframe_insertion (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3791 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3176 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Gln1084Arg rpoC_p.Gln1084Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3361 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2795 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gln1084Lys rpoC_p.Gln1084Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3682 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3079 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gln1110His rpoC_p.Gln1110His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 23 0 16787 30532 0.00136823319452706 0.000867533996903047 0.00205231857920666 1 0.999879187193184 1 1 0.851814871084775 1 NA NA NA NA NA NA NA NA NA NA 3518 4649 False False Inf 10.4516780546009 Inf 0 0 0.000219722057257406 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 12 0 11490 23707 0.0010432968179447 0.000539199208333142 0.00182171963730016 1 0.999844409142079 1 1 0.735351530602948 1 NA NA NA NA NA NA NA NA NA NA 2937 3890 False False 0 0 0 0 0 0 0 Inf 5.7314630344545 Inf 0 0 0.000320999770035263 1 0.999844409142079 1 2 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gln1110Pro rpoC_p.Gln1110Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3683 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3080 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gln1125Arg rpoC_p.Gln1125Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Gln1125His rpoC_p.Gln1125His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 21 0 16789 30532 0.00124925639500297 0.000773470498752546 0.00190899053306069 1 0.999879187193184 1 1 0.83890238478092 1 NA NA NA NA NA NA NA NA NA NA 3684 4649 False False Inf 9.46741729237089 Inf 0 0 0.000219695885606983 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 18 0 11484 23707 0.00156494522691705 0.000927741172595553 0.00247216477869727 1 0.999844409142079 1 1 0.814698031862147 1 NA NA NA NA NA NA NA NA NA NA 3081 3890 False False 0 0 0 0 0 0 0 Inf 9.07265194886324 Inf 0 0 0.000321167454579243 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gln1139Arg rpoC_p.Gln1139Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3362 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2796 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gln1139His rpoC_p.Gln1139His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3835 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3217 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gln1139Leu rpoC_p.Gln1139Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3622 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3026 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gln1145His rpoC_p.Gln1145His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3753 4649 False False Inf 1.1990579265185 Inf 0 0 0.000219473678051534 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3143 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gln1273Arg rpoC_p.Gln1273Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 7 16810 30525 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 1.26007067420399 0.0561478031672613 154 4649 False False 0 0 1.26007067420399 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 7 11502 23700 0 0 0.000320664925697395 0.999704728561184 0.999391723222185 0.999881277590374 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 1.42986888806462 0.104255162462523 134.5 3890 False False 0 0 0 0 0 0 0 0 0 1.42986888806462 0 0 0.000320664925697395 0.999704728561184 0.999391723222185 0.999881277590374 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Gln165Arg rpoC_p.Gln165Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Gln207Arg rpoC_p.Gln207Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3685 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3082 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gln22Arg rpoC_p.Gln22Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 11 0 11 0 12 16810 30520 0 0 0.000219421459229958 0.999606969736669 0.999313555980458 0.999796899563454 0 0 0.264648469397051 0 0 0.284914152918154 0 0 0.264648469397051 0 0 0.723498419646924 0.0103093117636392 103.5 4649 False False 0 0 0.653527260731835 0 0 0.000219421459229958 0.999606969736669 0.999313555980458 0.999796899563454 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 0 9 11502 23698 0 0 0.000320664925697395 0.999620365292951 0.999279457952852 0.99982639261309 0 0 0.336267116879942 0 0 0.369416647552819 0 0 0.336267116879942 0 0 1.20726675935225 0.0599133727630747 114.5 3890 False False 0 0 0 0 0 0 0 0 0 1.04405446176545 0 0 0.000320664925697395 0.999620365292951 0.999279457952852 0.99982639261309 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Gln22Leu rpoC_p.Gln22Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3809 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3194 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gln262Arg rpoC_p.Gln262Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 80.2910622977969 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Gln262His rpoC_p.Gln262His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3474 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2892 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gln303Leu rpoC_p.Gln303Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 4 4 16806 30528 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999868989912223 0.999664596427238 0.999964303043777 0.5 0.157012770487058 0.842987229512941 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3810 4649 False False 1.81649410924669 0.338292932357021 9.7540407308173 0 0 0.000219473678051534 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 4 4 11498 23703 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 0.999831273463534 0.999568049920357 0.99995402584539 0.5 0.157012770487058 0.842987229512941 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3195 3890 False False 0 0 0 0 0 0 0 2.0614889546008 0.383888088909897 11.0704740677885 0 0 0.000320776462830572 0.999831273463534 0.999568049920357 0.99995402584539 1 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Gln415Arg rpoC_p.Gln415Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3475 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2893 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gln415His rpoC_p.Gln415His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3836 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3218 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gln435His rpoC_p.Gln435His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 8 0 16802 30532 0.000475907198096371 0.00020548462525215 0.000937510381255989 1 0.999879187193184 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 3556 4649 False False Inf 3.10133467016734 Inf 0 0 0.000219525921733526 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 8 0 11494 23707 0.000695531211963136 0.000300327312744212 0.00137001129783907 1 0.999844409142079 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 2969 3890 False False 0 0 0 0 0 0 0 Inf 3.51981666109462 Inf 0 0 0.000320888077582845 1 0.999844409142079 1 2 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gln435Pro rpoC_p.Gln435Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 5 0 16805 30532 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 1 0.999879187193184 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 3476 4649 False False Inf 1.66460481015123 Inf 0 0 0.000219486736640675 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 11498 23707 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 1 0.999844409142079 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2894 3890 False False 0 0 0 0 0 0 0 Inf 1.3608069907404 Inf 0 0 0.000320776462830572 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gln440Arg rpoC_p.Gln440Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 10 0 10 1 10 16809 30522 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999672474780558 0.999397752220648 0.999842928110511 0.0909090909090909 0.00229897221381426 0.412779916988382 0 0 0.30849710781876 0 0 0.30849710781876 0 0 0.810211030214242 0.0177778141076423 122 4649 False False 0.181581295734428 0.00418792370416041 1.27663177447289 0 0 0.000219434511605659 0.999672474780558 0.999397752220648 0.999842928110511 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Gln479Arg rpoC_p.Gln479Arg 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 19 0 16791 30532 0.00113027959547888 0.000680635004098699 0.00176451134196716 1 0.999879187193184 1 1 0.823533088193034 1 NA NA NA NA NA NA NA NA NA NA 3792 4649 False False Inf 8.48468002646117 Inf 0 0 0.000219669720190561 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 11 0 11491 23707 0.000956355416449313 0.000477502787107626 0.00171053820723243 1 0.999844409142079 1 1 0.715085847081845 1 NA NA NA NA NA NA NA NA NA NA 3177 3890 False False 0 0 0 0 0 0 0 Inf 5.1761760609822 Inf 0 0 0.000320971839633333 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gln479His rpoC_p.Gln479His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Gln479Pro rpoC_p.Gln479Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3793 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3178 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gln482Lys rpoC_p.Gln482Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3380 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2811 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gln523Glu rpoC_p.Gln523Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 10 0 16800 30532 0.000594883997620464 0.000285305684944214 0.00109373983334496 1 0.999879187193184 1 1 0.691502892181239 1 NA NA NA NA NA NA NA NA NA NA 3607 4649 False False Inf 4.07313735951873 Inf 0 0 0.000219552052902727 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 7 0 11495 23707 0.000608589810467744 0.000244718560881119 0.00125352303681455 1 0.999844409142079 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 3013 3890 False False 0 0 0 0 0 0 0 Inf 2.97179240572548 Inf 0 0 0.000320860166613556 1 0.999844409142079 1 8 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gln523Lys rpoC_p.Gln523Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 6 0 16804 30532 0.000356930398572278 0.000130998068917797 0.000776724091447791 1 0.999879187193184 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 3590 4649 False False Inf 2.13890645017026 Inf 0 0 0.000219499796783869 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 6 0 11496 23707 0.000521648408972352 0.000191459062774625 0.00113506056981396 1 0.999844409142079 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 3000 3890 False False 0 0 0 0 0 0 0 Inf 2.42738974088595 Inf 0 0 0.000320832260499258 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gln657Arg rpoC_p.Gln657Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 4.39540875925228 0.556930310247326 910.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 10.9713274274722 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Gln687dup rpoC_p.Gln687dup 2 inframe_insertion (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3623 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3027 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gln759Arg rpoC_p.Gln759Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Gln761Arg rpoC_p.Gln761Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3557 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2970 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gln761Lys rpoC_p.Gln761Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3572 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gln959Arg rpoC_p.Gln959Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3477 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2895 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Glu1022Asp rpoC_p.Glu1022Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3640 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3040 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu1022Lys rpoC_p.Glu1022Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3413 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2840 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu1033Ala rpoC_p.Glu1033Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 68 23 16742 30509 0.00404521118381915 0.00314259286191042 0.00512549026226486 0.999246691995283 0.998869881214224 0.999522409302755 0.747252747252747 0.645272404419328 0.832544918595091 NA NA NA 0 0 0.148185128915224 NA NA NA NA 3503 4649 False False 5.38767899528911 3.31342923478855 9.06282742367404 0 0 0.000220312572328917 0.999246691995283 0.998869881214224 0.999522409302755 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 46 21 11456 23686 0.00399930446878803 0.00292943659823562 0.00533094854709251 0.999114185683553 0.998646255755329 0.99945158598871 0.686567164179104 0.561601984068593 0.794421275866693 NA NA NA 0 0 0.161097615219079 NA NA NA NA 2922 3890 False False 0 0 0 0 0 0 0 4.5289471934025 2.64715452471446 7.99202343681646 0 0 0.000321952304523779 0.999114185683553 0.998646255755329 0.99945158598871 14 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Glu1033Asp rpoC_p.Glu1033Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 16 0 16794 30532 0.000951814396192742 0.000544138942285324 0.00154522796648703 1 0.999879187193184 1 1 0.794092785792177 1 NA NA NA NA NA NA NA NA NA NA 3535 4649 False False Inf 7.00986495552168 Inf 0 0 0.000219630483749807 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 15 0 11487 23707 0.00130412102243088 0.000730084557867185 0.00215003854003137 1 0.999844409142079 1 1 0.781980639089466 1 NA NA NA NA NA NA NA NA NA NA 2951 3890 False False 0 0 0 0 0 0 0 Inf 7.40065484717093 Inf 0 0 0.000321083590414119 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu1033Gln rpoC_p.Glu1033Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3536 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2952 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu1033Gly rpoC_p.Glu1033Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 5 1 16805 30531 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 0.999967247478055 0.999817528289014 0.999999170778282 0.833333333333333 0.358765421002325 0.99578925548551 NA NA NA 0 0 0.975 NA NA NA NA 3641 4649 False False 9.08390360011901 1.01631102884943 428.726615606949 0 0 0.000219486736640675 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 3 1 11499 23706 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.999957818365883 0.999765001636458 0.999998932054057 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 3041 3890 False False 0 0 0 0 0 0 0 6.18471171406209 0.496496186771195 324.103527365594 0 0 0.000320748571273651 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu1033Lys rpoC_p.Glu1033Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 29 0 16781 30532 0.00172516359309934 0.00115566411224569 0.00247669038907857 1 0.999879187193184 1 1 0.880555130930497 1 NA NA NA NA NA NA NA NA NA NA 3761 4649 False False Inf 13.4077314477923 Inf 0 0 0.000219800609634964 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 18 0 11484 23707 0.00156494522691705 0.000927741172595553 0.00247216477869727 1 0.999844409142079 1 1 0.814698031862147 1 NA NA NA NA NA NA NA NA NA NA 3149 3890 False False 0 0 0 0 0 0 0 Inf 9.07265194886324 Inf 0 0 0.000321167454579243 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu1033Val rpoC_p.Glu1033Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 6 0 16804 30532 0.000356930398572278 0.000130998068917797 0.000776724091447791 1 0.999879187193184 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 3573 4649 False False Inf 2.13890645017026 Inf 0 0 0.000219499796783869 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 11498 23707 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 1 0.999844409142079 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2985 3890 False False 0 0 0 0 0 0 0 Inf 1.3608069907404 Inf 0 0 0.000320776462830572 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu1056Asp rpoC_p.Glu1056Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Glu1073Asp rpoC_p.Glu1073Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3519 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2938 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Glu1073Gln rpoC_p.Glu1073Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 3794 4649 False False 0 0 1.9820231071276 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 3179 3890 False False 0 0 0 0 0 0 0 0 0 2.24912710990902 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Glu1073Lys rpoC_p.Glu1073Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 6 16810 30526 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 3363 4649 False False 0 0 1.54251408011679 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 11502 23701 0 0 0.000320664925697395 0.9997469101953 0.999449212060655 0.99990711502044 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 2797 3890 False False 0 0 0 0 0 0 0 0 0 1.75038628279554 0 0 0.000320664925697395 0.9997469101953 0.999449212060655 0.99990711502044 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Glu1074Asp rpoC_p.Glu1074Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3520 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2939 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu1092Asp rpoC_p.Glu1092Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2117 1216 14693 29316 0.125936942296252 0.120956746867334 0.131046947782114 0.960172933315865 0.957918853143489 0.962338911803796 0.635163516351635 0.618557925017862 0.651531618522812 NA NA NA 0 0 0.0030290212025885 NA NA NA NA NA NA False True 3.47361368822246 3.22643295322144 3.7406999777537 0 0 0.000251032220849295 0.960172933315865 0.957918853143489 0.962338911803796 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 1887 1076 9615 22631 0.164058424621804 0.157332787401718 0.170954546088517 0.95461256169064 0.951885513947822 0.957227444603639 0.636854539318258 0.619241579530757 0.654196827633695 NA NA NA 0 0 0.00342245662848612 NA NA NA NA NA NA False True 0 1 1 0 0 1 1 4.12775664186418 3.81292936340968 4.46972304532948 0 0 0.000383585221950296 0.95461256169064 0.951885513947822 0.957227444603639 623 Not assoc w R 5) Not assoc w R No change yes 1 +Rifampicin rpoC p.Glu1096Asp rpoC_p.Glu1096Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Glu1113Asp rpoC_p.Glu1113Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3837 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3219 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Glu1113Gly rpoC_p.Glu1113Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 10 0 16800 30532 0.000594883997620464 0.000285305684944214 0.00109373983334496 1 0.999879187193184 1 1 0.691502892181239 1 NA NA NA NA NA NA NA NA NA NA 3838 4649 False False Inf 4.07313735951873 Inf 0 0 0.000219552052902727 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 6 0 11496 23707 0.000521648408972352 0.000191459062774625 0.00113506056981396 1 0.999844409142079 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 3220 3890 False False 0 0 0 0 0 0 0 Inf 2.42738974088595 Inf 0 0 0.000320832260499258 1 0.999844409142079 1 11 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu1113Lys rpoC_p.Glu1113Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3762 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3150 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu1120Gly rpoC_p.Glu1120Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3624 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3028 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu1137Ala rpoC_p.Glu1137Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3642 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3042 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu1137Gly rpoC_p.Glu1137Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 45 0 16765 30532 0.00267697798929208 0.00195325583726912 0.00358038570852014 1 0.999879187193184 1 1 0.921294899593156 1 NA NA NA NA NA NA NA NA NA NA 3422 4649 False False Inf 21.3144146267478 Inf 0 0 0.000220010357494106 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 41 0 11461 23707 0.00356459746131107 0.00255919435806085 0.00483270406615093 1 0.999844409142079 1 1 0.913956163705971 1 NA NA NA NA NA NA NA NA NA NA 2848 3890 False False 0 0 0 0 0 0 0 Inf 21.965266136217 Inf 0 0 0.000321811871535852 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu1140Asp rpoC_p.Glu1140Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Glu1140Gln rpoC_p.Glu1140Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3478 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2896 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu1140Gly rpoC_p.Glu1140Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Glu1185Lys rpoC_p.Glu1185Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3447 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2870 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu1189Asp rpoC_p.Glu1189Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Glu1196Lys rpoC_p.Glu1196Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3490 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2909 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Glu1228Ala rpoC_p.Glu1228Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3521 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu1250Ala rpoC_p.Glu1250Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3537 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu126Asp rpoC_p.Glu126Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Glu1277Lys rpoC_p.Glu1277Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3423 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2849 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Glu1289Ala rpoC_p.Glu1289Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Glu1289Gly rpoC_p.Glu1289Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Glu142Ala rpoC_p.Glu142Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3643 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3043 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Glu142Gly rpoC_p.Glu142Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Glu163Asp rpoC_p.Glu163Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3664 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3060 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu171Lys rpoC_p.Glu171Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Glu178Gly rpoC_p.Glu178Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu185Gln rpoC_p.Glu185Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Glu185Gly rpoC_p.Glu185Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3591 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3001 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu187Gly rpoC_p.Glu187Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3479 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2897 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu18Asp rpoC_p.Glu18Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Glu18Gln rpoC_p.Glu18Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Glu202Asp rpoC_p.Glu202Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu215Ala rpoC_p.Glu215Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3381 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2812 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Glu259Lys rpoC_p.Glu259Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Glu323Gly rpoC_p.Glu323Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3855 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3236 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu450Gln rpoC_p.Glu450Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3558 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2971 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu450Gly rpoC_p.Glu450Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3665 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3061 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu488Asp rpoC_p.Glu488Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3839 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3221 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu488Gln rpoC_p.Glu488Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 12 0 16798 30532 0.000713860797144556 0.000368914962606047 0.00124663876852724 1 0.999879187193184 1 1 0.735351530602948 1 NA NA NA NA NA NA NA NA NA NA 3625 4649 False False Inf 5.04894728912605 Inf 0 0 0.000219578190293692 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 9 0 11493 23707 0.000782472613458529 0.000357856744032263 0.00148485474620048 1 0.999844409142079 1 1 0.663732883120057 1 NA NA NA NA NA NA NA NA NA NA 3029 3890 False False 0 0 0 0 0 0 0 Inf 4.07050547199104 Inf 0 0 0.000320915993408392 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu488Gly rpoC_p.Glu488Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 6 0 16804 30532 0.000356930398572278 0.000130998068917797 0.000776724091447791 1 0.999879187193184 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 3480 4649 False False Inf 2.13890645017026 Inf 0 0 0.000219499796783869 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 6 0 11496 23707 0.000521648408972352 0.000191459062774625 0.00113506056981396 1 0.999844409142079 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 2898 3890 False False 0 0 0 0 0 0 0 Inf 2.42738974088595 Inf 0 0 0.000320832260499258 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu489del rpoC_p.Glu489del 2 inframe_deletion (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3763 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3151 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu49Ala rpoC_p.Glu49Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3825 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3208 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Glu49Gln rpoC_p.Glu49Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3754 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu49Gly rpoC_p.Glu49Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3382 4649 False False Inf 1.1990579265185 Inf 0 0 0.000219473678051534 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2813 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu513Gln rpoC_p.Glu513Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 8 0 16802 30532 0.000475907198096371 0.00020548462525215 0.000937510381255989 1 0.999879187193184 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 3856 4649 False False Inf 3.10133467016734 Inf 0 0 0.000219525921733526 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 8 0 11494 23707 0.000695531211963136 0.000300327312744212 0.00137001129783907 1 0.999844409142079 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 3237 3890 False False 0 0 0 0 0 0 0 Inf 3.51981666109462 Inf 0 0 0.000320888077582845 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu518Ala rpoC_p.Glu518Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3811 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3196 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu518Asp rpoC_p.Glu518Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 20 0 16790 30532 0.00118976799524092 0.000726887900057249 0.00183690503094944 1 0.999879187193184 1 1 0.831566529016914 1 NA NA NA NA NA NA NA NA NA NA 3574 4649 False False Inf 8.97808458256773 Inf 0 0 0.000219682802119661 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 16 0 11486 23707 0.00139106242392627 0.000795314835170056 0.00225801785882213 1 0.999844409142079 1 1 0.794092785792177 1 NA NA NA NA NA NA NA NA NA NA 2986 3890 False False 0 0 0 0 0 0 0 Inf 7.95612579230723 Inf 0 0 0.000321111540268992 1 0.999844409142079 1 2 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu518Gln rpoC_p.Glu518Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3608 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3014 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu518Lys rpoC_p.Glu518Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3840 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3222 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu591Asp rpoC_p.Glu591Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3704 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3101 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu591Gln rpoC_p.Glu591Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 4 1 16806 30531 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999967247478055 0.999817528289014 0.999999170778282 0.8 0.28358206388191 0.994949236620532 NA NA NA 0 0 0.975 NA NA NA NA 3364 4649 False False 7.26669046769011 0.71899465830523 357.208630433948 0 0 0.000219473678051534 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2798 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Glu59Gly rpoC_p.Glu59Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3686 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu608Gln rpoC_p.Glu608Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3812 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3197 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu617Asp rpoC_p.Glu617Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu645Lys rpoC_p.Glu645Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Glu647Lys rpoC_p.Glu647Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu702Lys rpoC_p.Glu702Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3522 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2940 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu744Gly rpoC_p.Glu744Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3424 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu750Ala rpoC_p.Glu750Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3396 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu750Asp rpoC_p.Glu750Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 17 0 16793 30532 0.00101130279595478 0.000589228022589122 0.0016187015795436 1 0.999879187193184 1 1 0.804935677030906 1 1 0.025 1 1 0.025 1 Inf 0.0466159698140585 Inf 0.354857794869627 383 4649 False False Inf 7.50125453808733 Inf 5.9545075622246e-05 1.50754965465992e-06 0.000331718774379133 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 15 0 11487 23707 0.00130412102243088 0.000730084557867185 0.00215003854003137 1 0.999844409142079 1 1 0.781980639089466 1 1 0.025 1 1 0.025 1 Inf 0.0529134656258865 Inf 0.326410001420656 309 3890 False False 0 0 0 0 0 0 0 Inf 7.40065484717093 Inf 8.70473537604456e-05 2.20384575957588e-06 0.000484900322174504 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu750Gln rpoC_p.Glu750Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 11 0 16799 30532 0.00065437239738251 0.000326704163498642 0.00117055062018267 1 0.999879187193184 1 1 0.715085847081845 1 NA NA NA NA NA NA NA NA NA NA 3841 4649 False False Inf 4.56066720991606 Inf 0 0 0.000219565120820351 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 8 0 11494 23707 0.000695531211963136 0.000300327312744212 0.00137001129783907 1 0.999844409142079 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 3223 3890 False False 0 0 0 0 0 0 0 Inf 3.51981666109462 Inf 0 0 0.000320888077582845 1 0.999844409142079 1 2 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu750Gly rpoC_p.Glu750Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 14 0 16796 30532 0.000832837596668649 0.000455392489979272 0.00139696554892221 1 0.999879187193184 1 1 0.768364238349883 1 NA NA NA NA NA NA NA NA NA NA 3462 4649 False False Inf 6.02871753174659 Inf 0 0 0.000219604333908644 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 8 0 11494 23707 0.000695531211963136 0.000300327312744212 0.00137001129783907 1 0.999844409142079 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 2882 3890 False False 0 0 0 0 0 0 0 Inf 3.51981666109462 Inf 0 0 0.000320888077582845 1 0.999844409142079 1 4 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu757Ala rpoC_p.Glu757Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 14 0 16796 30532 0.000832837596668649 0.000455392489979272 0.00139696554892221 1 0.999879187193184 1 1 0.768364238349883 1 NA NA NA NA NA NA NA NA NA NA 3491 4649 False False Inf 6.02871753174659 Inf 0 0 0.000219604333908644 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 11498 23707 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 1 0.999844409142079 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2910 3890 False False 0 0 0 0 0 0 0 Inf 1.3608069907404 Inf 0 0 0.000320776462830572 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu757Gly rpoC_p.Glu757Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 20 0 16790 30532 0.00118976799524092 0.000726887900057249 0.00183690503094944 1 0.999879187193184 1 1 0.831566529016914 1 NA NA NA NA NA NA NA NA NA NA 3764 4649 False False Inf 8.97808458256773 Inf 0 0 0.000219682802119661 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 12 0 11490 23707 0.0010432968179447 0.000539199208333142 0.00182171963730016 1 0.999844409142079 1 1 0.735351530602948 1 NA NA NA NA NA NA NA NA NA NA 3152 3890 False False 0 0 0 0 0 0 0 Inf 5.7314630344545 Inf 0 0 0.000320999770035263 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu757Lys rpoC_p.Glu757Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3425 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2850 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu769Gly rpoC_p.Glu769Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3365 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2799 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu784Gln rpoC_p.Glu784Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 58 16809 30474 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.998100353727237 0.997544949665314 0.998557212644086 0.0169491525423728 0.000429023332723594 0.0908559328866492 NA NA NA 0 0 0.0616210089039198 NA NA NA NA NA NA False True 0.0312578852462043 0.000782577948568783 0.181213602257757 0 0 0.000219434511605659 0.998100353727237 0.997544949665314 0.998557212644086 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 58 11502 23649 0 0 0.000320664925697395 0.997553465221242 0.99683841939605 0.99814173543455 0 0 0.0616210089039198 NA NA NA 0 0 0.0616210089039198 NA NA NA NA NA NA False True 1 1 1 0 0 1 0 0 0 0.135043764297734 0 0 0.000320664925697395 0.997553465221242 0.99683841939605 0.99814173543455 NA Not assoc w R 5) Not assoc w R No change yes 1 +Rifampicin rpoC p.Glu784Gly rpoC_p.Glu784Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3366 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2800 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu791Ala rpoC_p.Glu791Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3367 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2801 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Glu791Asp rpoC_p.Glu791Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3795 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3180 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu791Gln rpoC_p.Glu791Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 1 7 16809 30525 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.99977073234639 0.999527678427408 0.999907817703152 0.125 0.0031597235312519 0.526509670875206 0 0 0.4592581264399 0 0 0.409616397225003 0 0 1.54255532235522 0.0957807145055966 203 4649 False False 0.2594273475944 0.00575995110596449 2.01970184240593 0 0 0.000219434511605659 0.99977073234639 0.999527678427408 0.999907817703152 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 1 7 11501 23700 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999704728561184 0.999391723222185 0.999881277590374 0.125 0.0031597235312519 0.526509670875206 0 0 0.4592581264399 0 0 0.409616397225003 0 0 1.75046460046947 0.186839191554249 209.5 3890 False False 0 0 0 0 0 0 0 0.294384339250003 0.00653526389697788 2.29204336611244 0 0 0.000320692802708327 0.999704728561184 0.999391723222185 0.999881277590374 2 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Glu830Ala rpoC_p.Glu830Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3813 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu830Gln rpoC_p.Glu830Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3448 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu894Gly rpoC_p.Glu894Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3538 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2953 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Glu903Ala rpoC_p.Glu903Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3592 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu90Gly rpoC_p.Glu90Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3871 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3249 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Glu932Lys rpoC_p.Glu932Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3705 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3102 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Glu948Ala rpoC_p.Glu948Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0465715996825058 Inf 0.355075831185839 416 4649 False False Inf 0.0465715996825058 Inf 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Gly1026Ala rpoC_p.Gly1026Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 3 2 16807 30530 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999934494956111 0.999763393503742 0.99999206693684 0.6 0.146632799634673 0.947255049473683 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.67232174050862 0.542020050820051 749.5 4649 False False 2.72475754150056 0.312074221533576 32.6324551811023 0 0 0.000219460621016169 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.9727417274169 1 1214.5 3890 False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 0 0 0.000320692802708327 0.999915636731767 0.999695284447545 0.999989783053538 1 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Gly1042Asp rpoC_p.Gly1042Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 6 0 16804 30532 0.000356930398572278 0.000130998068917797 0.000776724091447791 1 0.999879187193184 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 3687 4649 False False Inf 2.13890645017026 Inf 0 0 0.000219499796783869 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3083 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gly1042dup rpoC_p.Gly1042dup 2 inframe_insertion (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3842 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gly1072Asp rpoC_p.Gly1072Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 11 16810 30521 0 0 0.000219421459229958 0.999639722258614 0.999355455254591 0.999820137367966 0 0 0.284914152918154 NA NA NA 0 0 0.284914152918154 NA NA NA NA 3492 4649 False False 0 0 0.723522114724776 0 0 0.000219421459229958 0.999639722258614 0.999355455254591 0.999820137367966 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 7 11502 23700 0 0 0.000320664925697395 0.999704728561184 0.999391723222185 0.999881277590374 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 2911 3890 False False 0 0 0 0 0 0 0 0 0 1.42986888806462 0 0 0.000320664925697395 0.999704728561184 0.999391723222185 0.999881277590374 2 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Gly1108Cys rpoC_p.Gly1108Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3383 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2814 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gly1108Ser rpoC_p.Gly1108Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3644 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3044 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gly1114Arg rpoC_p.Gly1114Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3626 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3030 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gly1178Ser rpoC_p.Gly1178Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3765 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3153 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gly1198Ser rpoC_p.Gly1198Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 16 1 16794 30531 0.000951814396192742 0.000544138942285324 0.00154522796648703 0.999967247478055 0.999817528289014 0.999999170778282 0.941176470588235 0.713110603332779 0.998511825608733 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0466116674913487 Inf 0.354878924903858 384 4649 False False 29.0875312611647 4.5180319701288 1212.73709524349 5.95415302173265e-05 1.50745989291426e-06 0.000331699026023794 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 16 1 11486 23706 0.00139106242392627 0.000795314835170056 0.00225801785882213 0.999957818365883 0.999765001636458 0.999998932054057 0.941176470588235 0.713110603332779 0.998511825608733 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0529158398489544 Inf 0.326400136390759 308 3890 False False 0 0 0 0 0 0 0 33.0224621278077 5.12866478124923 1375.56221955267 8.70549316618786e-05 2.20403761500644e-06 0.000484942526739114 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Gly1247Ser rpoC_p.Gly1247Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3645 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3045 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gly1311Ser rpoC_p.Gly1311Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Gly13Ala rpoC_p.Gly13Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3706 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3103 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gly13Arg rpoC_p.Gly13Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3397 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2825 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Gly188Ala rpoC_p.Gly188Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Gly254Ser rpoC_p.Gly254Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Gly286Glu rpoC_p.Gly286Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Gly311Arg rpoC_p.Gly311Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3727 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gly311Ser rpoC_p.Gly311Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Gly332Arg rpoC_p.Gly332Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 123 1 16687 30531 0.0073170731707317 0.00608478823137462 0.00872412750614615 0.999967247478055 0.999817528289014 0.999999170778282 0.991935483870967 0.955886996114799 0.999795844971633 0 0 0.975 0 0 0.975 0 0 71.2794630198352 1 1627.5 4649 False False 225.044226044226 39.6173090280582 8454.31378055345 0 0 0.000221038637660961 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 92 1 11410 23706 0.00799860893757607 0.00645273861683653 0.00980068947434154 0.999957818365883 0.999765001636458 0.999998932054057 0.989247311827957 0.941541835485619 0.999727802557992 0 0 0.975 0 0 0.975 0 0 80.9306107043401 1 1214.5 3890 False False 0 0 0 0 0 0 0 191.143908851884 33.4516432448479 7272.24818617667 0 0 0.000323250061939669 0.999957818365883 0.999765001636458 0.999998932054057 10 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Gly332Cys rpoC_p.Gly332Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 20 0 16790 30532 0.00118976799524092 0.000726887900057249 0.00183690503094944 1 0.999879187193184 1 1 0.831566529016914 1 NA NA NA NA NA NA NA NA NA NA 3426 4649 False False Inf 8.97808458256773 Inf 0 0 0.000219682802119661 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 17 0 11485 23707 0.00147800382542166 0.000861220016155565 0.00236537605429428 1 0.999844409142079 1 1 0.804935677030906 1 NA NA NA NA NA NA NA NA NA NA 2851 3890 False False 0 0 0 0 0 0 0 Inf 8.51620393516598 Inf 0 0 0.000321139494990277 1 0.999844409142079 1 4 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gly332Ser rpoC_p.Gly332Ser 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 183 0 16627 30532 0.0108863771564544 0.00937304848268776 0.0125723111353058 1 0.999879187193184 1 1 0.980043999158683 1 NA NA NA NA NA NA NA NA NA NA 3796 4649 False False Inf 89.9495710352692 Inf 0 0 0.000221836186654767 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 109 0 11393 23707 0.00947661276299774 0.00778756148243545 0.0114204225886466 1 0.999844409142079 1 1 0.966723335201491 1 NA NA NA NA NA NA NA NA NA NA 3181 3890 False False 0 0 0 0 0 0 0 Inf 60.4507262332294 Inf 0 0 0.000323732319594532 1 0.999844409142079 1 61 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gly333dup rpoC_p.Gly333dup 2 inframe_insertion (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3523 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gly388Ala rpoC_p.Gly388Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 17 0 16793 30532 0.00101130279595478 0.000589228022589122 0.0016187015795436 1 0.999879187193184 1 1 0.804935677030906 1 NA NA NA NA NA NA NA NA NA NA 3368 4649 False False Inf 7.50125453808733 Inf 0 0 0.000219643561005912 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 8 0 11494 23707 0.000695531211963136 0.000300327312744212 0.00137001129783907 1 0.999844409142079 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 2802 3890 False False 0 0 0 0 0 0 0 Inf 3.51981666109462 Inf 0 0 0.000320888077582845 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gly411Ser rpoC_p.Gly411Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3369 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Gly433Ala rpoC_p.Gly433Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 17 0 16793 30532 0.00101130279595478 0.000589228022589122 0.0016187015795436 1 0.999879187193184 1 1 0.804935677030906 1 NA NA NA NA NA NA NA NA NA NA 3872 4649 False False Inf 7.50125453808733 Inf 0 0 0.000219643561005912 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 14 0 11488 23707 0.00121717962093548 0.000665598145642159 0.00204137811638842 1 0.999844409142079 1 1 0.768364238349883 1 NA NA NA NA NA NA NA NA NA NA 3250 3890 False False 0 0 0 0 0 0 0 Inf 6.84328477771802 Inf 0 0 0.000321055645424387 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gly433Arg rpoC_p.Gly433Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 6 0 16804 30532 0.000356930398572278 0.000130998068917797 0.000776724091447791 1 0.999879187193184 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 3609 4649 False False Inf 2.13890645017026 Inf 0 0 0.000219499796783869 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 11498 23707 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 1 0.999844409142079 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3015 3890 False False 0 0 0 0 0 0 0 Inf 1.3608069907404 Inf 0 0 0.000320776462830572 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gly433Asp rpoC_p.Gly433Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3463 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gly433Cys rpoC_p.Gly433Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 8 0 16802 30532 0.000475907198096371 0.00020548462525215 0.000937510381255989 1 0.999879187193184 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 3814 4649 False False Inf 3.10133467016734 Inf 0 0 0.000219525921733526 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 6 0 11496 23707 0.000521648408972352 0.000191459062774625 0.00113506056981396 1 0.999844409142079 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 3198 3890 False False 0 0 0 0 0 0 0 Inf 2.42738974088595 Inf 0 0 0.000320832260499258 1 0.999844409142079 1 2 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gly433Ser rpoC_p.Gly433Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 102 0 16708 30532 0.00606781677572873 0.00495020853067057 0.00736112974154734 1 0.999879187193184 1 1 0.964480673342116 1 NA NA NA NA NA NA NA NA NA NA 3688 4649 False False Inf 49.6131530607393 Inf 0 0 0.000220760848638454 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 33 0 11469 23707 0.00286906624934793 0.00197573107651826 0.0040268977332274 1 0.999844409142079 1 1 0.89423718992542 1 NA NA NA NA NA NA NA NA NA NA 3084 3890 False False 0 0 0 0 0 0 0 Inf 17.4722896658069 Inf 0 0 0.000321587433401291 1 0.999844409142079 1 38 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gly519Arg rpoC_p.Gly519Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 12 0 16798 30532 0.000713860797144556 0.000368914962606047 0.00124663876852724 1 0.999879187193184 1 1 0.735351530602948 1 NA NA NA NA NA NA NA NA NA NA 3370 4649 False False Inf 5.04894728912605 Inf 0 0 0.000219578190293692 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 8 0 11494 23707 0.000695531211963136 0.000300327312744212 0.00137001129783907 1 0.999844409142079 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 2803 3890 False False 0 0 0 0 0 0 0 Inf 3.51981666109462 Inf 0 0 0.000320888077582845 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gly519Asp rpoC_p.Gly519Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 59 0 16751 30532 0.00350981558596073 0.00267287546013174 0.00452510169984734 1 0.999879187193184 1 1 0.93939109904966 1 NA NA NA NA NA NA NA NA NA NA 3741 4649 False False Inf 28.2205277545026 Inf 0 0 0.000220194215524371 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 46 0 11456 23707 0.00399930446878803 0.00292943659823562 0.00533094854709251 1 0.999844409142079 1 1 0.922938172948099 1 NA NA NA NA NA NA NA NA NA NA 3131 3890 False False 0 0 0 0 0 0 0 Inf 24.7752879195901 Inf 0 0 0.000321952304523779 1 0.999844409142079 1 19 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Gly519Cys rpoC_p.Gly519Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3539 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2954 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gly519Ser rpoC_p.Gly519Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 9 0 16801 30532 0.000535395597858417 0.000244845253515427 0.00101610321951737 1 0.999879187193184 1 1 0.663732883120057 1 NA NA NA NA NA NA NA NA NA NA 3873 4649 False False Inf 3.58631764003717 Inf 0 0 0.000219538986540545 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 6 0 11496 23707 0.000521648408972352 0.000191459062774625 0.00113506056981396 1 0.999844409142079 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 3251 3890 False False 0 0 0 0 0 0 0 Inf 2.42738974088595 Inf 0 0 0.000320832260499258 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gly571Arg rpoC_p.Gly571Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 17 0 16793 30532 0.00101130279595478 0.000589228022589122 0.0016187015795436 1 0.999879187193184 1 1 0.804935677030906 1 NA NA NA NA NA NA NA NA NA NA 3797 4649 False False Inf 7.50125453808733 Inf 0 0 0.000219643561005912 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 15 0 11487 23707 0.00130412102243088 0.000730084557867185 0.00215003854003137 1 0.999844409142079 1 1 0.781980639089466 1 NA NA NA NA NA NA NA NA NA NA 3182 3890 False False 0 0 0 0 0 0 0 Inf 7.40065484717093 Inf 0 0 0.000321083590414119 1 0.999844409142079 1 7 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gly594Arg rpoC_p.Gly594Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 2 16808 30530 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999934494956111 0.999763393503742 0.99999206693684 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 70.7645776857468 1 1627.5 4649 False False 1.8163969538315 0.131636449523742 25.0652602654423 0 0 0.000219447565534303 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 2 11500 23705 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999915636731767 0.999695284447545 0.999989783053538 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 80.2946525166223 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06130434782608 0.149383229063395 28.4413197127326 0 0 0.000320720684566658 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Gly594Glu rpoC_p.Gly594Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1559 4946 15251 25586 0.0927424152290303 0.0883984103738197 0.097227907097517 0.838006026464037 0.83382474226002 0.842122894282767 0.239661798616448 0.229329909979624 0.250227572011459 NA NA NA 0 0 0.00074555280145025 NA NA NA NA NA NA False True 0.528805638963887 0.497515029308304 0.561865148651645 0 0 0.000241848623757243 0.838006026464037 0.83382474226002 0.842122894282767 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 1064 3984 10438 19723 0.0925056511910972 0.0872707780127198 0.0979478024921708 0.831948369679841 0.827126962610629 0.83668825329039 0.210776545166402 0.199596013367684 0.22229249414982 NA NA NA 0 0 0.000925495022815852 NA NA NA NA NA NA False True 0 1 1 0 0 1 1 0.504635710883387 0.469287433717545 0.542336486128883 0 0 0.00035334620520675 0.831948369679841 0.827126962610629 0.83668825329039 397 Not assoc w R 5) Not assoc w R No change yes 1 +Rifampicin rpoC p.Gly604Arg rpoC_p.Gly604Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3646 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3046 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gly63Ala rpoC_p.Gly63Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Gly652Asp rpoC_p.Gly652Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3593 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3002 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Gly655Ser rpoC_p.Gly655Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Gly655Val rpoC_p.Gly655Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Gly669Ser rpoC_p.Gly669Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3540 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2955 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gly680Arg rpoC_p.Gly680Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Gly680Val rpoC_p.Gly680Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Gly72Asn rpoC_p.Gly72Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gly829Arg rpoC_p.Gly829Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3874 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gly855Ser rpoC_p.Gly855Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3826 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3209 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gly934Ser rpoC_p.Gly934Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3371 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2804 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gly941Asp rpoC_p.Gly941Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3728 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3120 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gly945Asp rpoC_p.Gly945Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 10 0 16800 30532 0.000594883997620464 0.000285305684944214 0.00109373983334496 1 0.999879187193184 1 1 0.691502892181239 1 1 0.025 1 1 0.025 1 Inf 0.0465965474829204 Inf 0.354953203895802 386 4649 False False Inf 4.07313735951873 Inf 5.95202666507946e-05 1.50692154683113e-06 0.000331580585252994 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 7 0 11495 23707 0.000608589810467744 0.000244718560881119 0.00125352303681455 1 0.999844409142079 1 1 0.590383602774996 1 1 0.025 1 1 0.025 1 Inf 0.0528766432074183 Inf 0.326563077010481 312 3890 False False 0 0 0 0 0 0 0 Inf 2.97179240572548 Inf 8.69867780097425e-05 2.20231211772982e-06 0.000484562949934275 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gly945Val rpoC_p.Gly945Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 6 0 16804 30532 0.000356930398572278 0.000130998068917797 0.000776724091447791 1 0.999879187193184 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 3707 4649 False False Inf 2.13890645017026 Inf 0 0 0.000219499796783869 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3104 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 6 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gly956Asp rpoC_p.Gly956Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3755 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3144 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gly980Glu rpoC_p.Gly980Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 1 7 16809 30525 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.99977073234639 0.999527678427408 0.999907817703152 0.125 0.0031597235312519 0.526509670875206 0 0 0.409616397225003 0 0 0.409616397225003 0 0 1.26014564687128 0.0561525818949018 163 4649 False False 0.2594273475944 0.00575995110596449 2.01970184240593 0 0 0.000219434511605659 0.99977073234639 0.999527678427408 0.999907817703152 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 11502 23701 0 0 0.000320664925697395 0.9997469101953 0.999449212060655 0.99990711502044 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.75038628279554 0.186840354932931 214 3890 False False 0 0 0 0 0 0 0 0 0 1.75038628279554 0 0 0.000320664925697395 0.9997469101953 0.999449212060655 0.99990711502044 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Gly986Cys rpoC_p.Gly986Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3627 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3031 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Gly992Ala rpoC_p.Gly992Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3647 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3047 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.His103Arg rpoC_p.His103Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3504 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2923 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.His1133Asn rpoC_p.His1133Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3524 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2941 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.His1133Tyr rpoC_p.His1133Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3493 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2912 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.His145Tyr rpoC_p.His145Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.His465Tyr rpoC_p.His465Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.His525Asn rpoC_p.His525Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 24 0 16786 30532 0.00142772159428911 0.000914975681329737 0.00212359656152999 1 0.999879187193184 1 1 0.857526402277474 1 NA NA NA NA NA NA NA NA NA NA 3398 4649 False False Inf 10.9456411420228 Inf 0 0 0.000219735145421064 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 22 0 11480 23707 0.00191271083289862 0.00119906180010764 0.00289444346770694 1 0.999844409142079 1 1 0.845627487184425 1 NA NA NA NA NA NA NA NA NA NA 2826 3890 False False 0 0 0 0 0 0 0 Inf 11.3088830935203 Inf 0 0 0.000321279341637369 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.His525Gln rpoC_p.His525Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 43 4 16767 30528 0.00255800118976799 0.00185183780155513 0.00344408115441007 0.999868989912223 0.999664596427238 0.999964303043777 0.914893617021276 0.796207303587466 0.976322907896102 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3766 4649 False False 19.5727321524423 7.10979144162045 75.075064282138 0 0 0.000219984117122384 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 35 4 11467 23703 0.00304294905233872 0.00212041293060913 0.00422948863748576 0.999831273463534 0.999568049920357 0.99995402584539 0.897435897435897 0.757790273049382 0.971339894873903 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3154 3890 False False 0 0 0 0 0 0 0 18.0867925351007 6.46425255366218 69.9519536284407 0 0 0.000321643513580867 0.999831273463534 0.999568049920357 0.99995402584539 4 3) Uncertain significance No change no 1 +Rifampicin rpoC p.His525Tyr rpoC_p.His525Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.His606Gln rpoC_p.His606Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3666 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3062 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.His653Ala rpoC_p.His653Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3541 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2956 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.His653Gln rpoC_p.His653Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.His689Arg rpoC_p.His689Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3542 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2957 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.His748Pro rpoC_p.His748Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 16 8 16794 30524 0.000951814396192742 0.000544138942285324 0.00154522796648703 0.999737979824446 0.999483781433772 0.999886871715824 0.666666666666666 0.446780384340351 0.843697714290864 NA NA NA 0 0 0.369416647552819 NA NA NA NA 3427 4649 False False 3.63510777658687 1.46744198948562 9.81360274065744 0 0 0.000219630483749807 0.999737979824446 0.999483781433772 0.999886871715824 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 14 8 11488 23699 0.00121717962093548 0.000665598145642159 0.00204137811638842 0.999662546927068 0.999335191784523 0.999854300817065 0.636363636363636 0.406576668825646 0.828020562353667 NA NA NA 0 0 0.369416647552819 NA NA NA NA 2852 3890 False False 0 0 0 0 0 0 0 3.6101366643454 1.41286919075536 9.93505830167193 0 0 0.000321055645424387 0.999662546927068 0.999335191784523 0.999854300817065 10 3) Uncertain significance No change no 1 +Rifampicin rpoC p.His748Ser rpoC_p.His748Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3575 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2987 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.His748Tyr rpoC_p.His748Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.His767Pro rpoC_p.His767Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 4 2 16806 30530 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999934494956111 0.999763393503742 0.99999206693684 0.666666666666666 0.222778095503512 0.956728131707258 0 0 0.975 0 0 0.841886116991581 0 0 70.7729897200484 1 1627.5 4649 False False 3.63322622872783 0.520625747830046 40.1764939558657 0 0 0.000219473678051534 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 2988 3890 False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 0 0 0.000320720684566658 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.His889Arg rpoC_p.His889Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ile1046Met rpoC_p.Ile1046Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 5 0 16805 30532 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 1 0.999879187193184 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 3414 4649 False False Inf 1.66460481015123 Inf 0 0 0.000219486736640675 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2841 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ile1046Val rpoC_p.Ile1046Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ile1066Val rpoC_p.Ile1066Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ile1080Met rpoC_p.Ile1080Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3708 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3105 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ile1080Thr rpoC_p.Ile1080Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3798 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3183 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ile1132Met rpoC_p.Ile1132Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 70.7603724184383 1 1627.5 4649 False False 0.908144446427509 0.0153974005043644 17.4461131425891 0 0 0.000219434511605659 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 80.2876797383181 1 1214.5 3890 False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 0 0 0.000320692802708327 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ile1157Met rpoC_p.Ile1157Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ile1264Thr rpoC_p.Ile1264Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 1 6 16809 30526 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999803484868334 0.999572318737888 0.999927879105266 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.54260585225547 0.0957834295462749 205.5 4649 False False 0.302675154183274 0.00658396461982027 2.49513982006856 0 0 0.000219434511605659 0.999803484868334 0.999572318737888 0.999927879105266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 1 5 11501 23702 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999789091829417 0.999507879904061 0.999931515258336 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.521823750104981 0 0 0.521823750104981 0 0 2.24932299250856 0.180435646558949 191.5 3890 False False 0 0 0 0 0 0 0 0.412172854534388 0.00871781959321125 3.68423590106777 0 0 0.000320692802708327 0.999789091829417 0.999507879904061 0.999931515258336 3 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ile1264Val rpoC_p.Ile1264Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 11 0 11 0 12 16810 30520 0 0 0.000219421459229958 0.999606969736669 0.999313555980458 0.999796899563454 0 0 0.264648469397051 0 0 0.284914152918154 0 0 0.264648469397051 0 0 0.723498419646924 0.0103093117636392 103.5 4649 False False 0 0 0.653527260731835 0 0 0.000219421459229958 0.999606969736669 0.999313555980458 0.999796899563454 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 0 11 11502 23696 0 0 0.000320664925697395 0.999536002024718 0.999169931473241 0.999768351851939 0 0 0.284914152918154 0 0 0.30849710781876 0 0 0.284914152918154 0 0 0.919308797237109 0.0366169211476112 108.5 3890 False False 0 0 0 0 0 0 0 0 0 0.821023972766749 0 0 0.000320664925697395 0.999536002024718 0.999169931473241 0.999768351851939 1 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ile1270Ser rpoC_p.Ile1270Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ile12Leu rpoC_p.Ile12Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ile12Val rpoC_p.Ile12Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 4 2 16806 30530 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999934494956111 0.999763393503742 0.99999206693684 0.666666666666666 0.222778095503512 0.956728131707258 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3543 4649 False False 3.63322622872783 0.520625747830046 40.1764939558657 0 0 0.000219473678051534 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 4 1 11498 23706 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 0.999957818365883 0.999765001636458 0.999998932054057 0.8 0.28358206388191 0.994949236620532 NA NA NA 0 0 0.975 NA NA NA NA 2958 3890 False False 0 0 0 0 0 0 0 8.24699947817011 0.815939832795188 405.284913246419 0 0 0.000320776462830572 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ile261Val rpoC_p.Ile261Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3843 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3224 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ile270Val rpoC_p.Ile270Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ile348Leu rpoC_p.Ile348Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ile34Val rpoC_p.Ile34Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3689 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3085 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ile358Val rpoC_p.Ile358Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ile491Asn rpoC_p.Ile491Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 9 0 16801 30532 0.000535395597858417 0.000244845253515427 0.00101610321951737 1 0.999879187193184 1 1 0.663732883120057 1 NA NA NA NA NA NA NA NA NA NA 3576 4649 False False Inf 3.58631764003717 Inf 0 0 0.000219538986540545 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 9 0 11493 23707 0.000782472613458529 0.000357856744032263 0.00148485474620048 1 0.999844409142079 1 1 0.663732883120057 1 NA NA NA NA NA NA NA NA NA NA 2989 3890 False False 0 0 0 0 0 0 0 Inf 4.07050547199104 Inf 0 0 0.000320915993408392 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ile491Ser rpoC_p.Ile491Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3559 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2972 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ile491Thr rpoC_p.Ile491Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 384 0 16426 30532 0.0228435455086258 0.0206381123027745 0.0252161259917462 1 0.999879187193184 1 1 0.990439537695875 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.349086396876468 Inf 0.122375935033109 216 4649 False False Inf 192.914606536427 Inf 0.000121743364986608 1.47440263637699e-05 0.000439708966722931 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 169 0 11333 23707 0.0146930968527212 0.0125742312897044 0.0170625048575316 1 0.999844409142079 1 1 0.978408811051769 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.392795337608698 Inf 0.104625935910464 144 3890 False False 0 0 0 0 0 0 0 Inf 94.6945993165906 Inf 0.000176444640494045 2.13689788616137e-05 0.000637231831241059 1 0.999844409142079 1 90 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ile491Val rpoC_p.Ile491Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 5 0 622 0 16188 30532 0.0370017846519928 0.0341988272005694 0.0399663567915217 1 0.999879187193184 1 1 0.99408687737066 1 1 0.478176249895018 1 1 0.478176249895018 1 Inf 1.72804838895473 Inf 0.00499706220016631 88 4649 False False Inf 317.736784564551 Inf 0.000308775396776384 0.000100265888856376 0.000720430415173317 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 3 0 306 0 11196 23707 0.0266040688575899 0.023740008428366 0.0297109788265291 1 0.999844409142079 1 1 0.988017210733985 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.874838062023899 Inf 0.0330185851183332 93 3890 False False 0 0 0 0 0 0 0 Inf 173.890091448142 Inf 0.000267881060809 5.52469221978766e-05 0.000782660579843829 1 0.999844409142079 1 145 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ile509Val rpoC_p.Ile509Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3729 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3121 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ile522Thr rpoC_p.Ile522Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3525 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2942 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ile565Met rpoC_p.Ile565Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 2 16808 30530 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999934494956111 0.999763393503742 0.99999206693684 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3844 4649 False False 1.8163969538315 0.131636449523742 25.0652602654423 0 0 0.000219447565534303 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 2 11500 23705 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999915636731767 0.999695284447545 0.999989783053538 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3225 3890 False False 0 0 0 0 0 0 0 2.06130434782608 0.149383229063395 28.4413197127326 0 0 0.000320720684566658 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ile565Thr rpoC_p.Ile565Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3742 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3132 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ile619Val rpoC_p.Ile619Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ile646Val rpoC_p.Ile646Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ile696Met rpoC_p.Ile696Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3610 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3016 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ile697Val rpoC_p.Ile697Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ile707Thr rpoC_p.Ile707Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3560 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2973 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ile745Leu rpoC_p.Ile745Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ile799Thr rpoC_p.Ile799Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3767 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3155 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ile800Thr rpoC_p.Ile800Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ile800Val rpoC_p.Ile800Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3561 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2974 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ile802Val rpoC_p.Ile802Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 16809 30529 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999901742434167 0.999712876815577 0.99997973646933 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.39581433818102 0.556927644280045 795 4649 False False 0.605409800305391 0.0115361654751757 7.54087213596152 0 0 0.000219434511605659 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 80.2910622977969 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ile832Val rpoC_p.Ile832Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 10 0 16800 30532 0.000594883997620464 0.000285305684944214 0.00109373983334496 1 0.999879187193184 1 1 0.691502892181239 1 NA NA NA NA NA NA NA NA NA NA 3875 4649 False False Inf 4.07313735951873 Inf 0 0 0.000219552052902727 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 9 0 11493 23707 0.000782472613458529 0.000357856744032263 0.00148485474620048 1 0.999844409142079 1 1 0.663732883120057 1 NA NA NA NA NA NA NA NA NA NA 3252 3890 False False 0 0 0 0 0 0 0 Inf 4.07050547199104 Inf 0 0 0.000320915993408392 1 0.999844409142079 1 3 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ile851Ser rpoC_p.Ile851Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3827 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ile851Thr rpoC_p.Ile851Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3709 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3106 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ile851Val rpoC_p.Ile851Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 15 0 16795 30532 0.000892325996430696 0.000499511372123772 0.00147132963433071 1 0.999879187193184 1 1 0.781980639089466 1 NA NA NA NA NA NA NA NA NA NA 3594 4649 False False Inf 6.51893136980533 Inf 0 0 0.00021961740805081 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 8 0 11494 23707 0.000695531211963136 0.000300327312744212 0.00137001129783907 1 0.999844409142079 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 3003 3890 False False 0 0 0 0 0 0 0 Inf 3.51981666109462 Inf 0 0 0.000320888077582845 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ile885Thr rpoC_p.Ile885Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3815 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3199 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ile885Val rpoC_p.Ile885Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 19 0 16791 30532 0.00113027959547888 0.000680635004098699 0.00176451134196716 1 0.999879187193184 1 1 0.823533088193034 1 NA NA NA NA NA NA NA NA NA NA 3464 4649 False False Inf 8.48468002646117 Inf 0 0 0.000219669720190561 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 13 0 11489 23707 0.00113023821944009 0.000601937155487611 0.00193196626494298 1 0.999844409142079 1 1 0.752947361999529 1 NA NA NA NA NA NA NA NA NA NA 2883 3890 False False 0 0 0 0 0 0 0 Inf 6.28688570681876 Inf 0 0 0.000321027705298525 1 0.999844409142079 1 8 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ile897Thr rpoC_p.Ile897Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3778 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3165 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ile916Val rpoC_p.Ile916Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3628 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3032 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ile949Val rpoC_p.Ile949Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3428 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2853 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ile957Thr rpoC_p.Ile957Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ile997Thr rpoC_p.Ile997Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3857 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3238 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ile997Val rpoC_p.Ile997Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3730 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Leu1028Val rpoC_p.Leu1028Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3372 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2805 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Leu1034Met rpoC_p.Leu1034Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3399 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2827 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Leu1099Pro rpoC_p.Leu1099Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3667 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3063 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Leu1099Val rpoC_p.Leu1099Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3731 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3122 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Leu1111Val rpoC_p.Leu1111Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3429 4649 False False Inf 1.1990579265185 Inf 0 0 0.000219473678051534 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 11498 23707 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 1 0.999844409142079 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2854 3890 False False 0 0 0 0 0 0 0 Inf 1.3608069907404 Inf 0 0 0.000320776462830572 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Leu1134Val rpoC_p.Leu1134Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3768 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3156 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Leu1245Arg rpoC_p.Leu1245Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3526 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2943 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Leu148Arg rpoC_p.Leu148Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Leu14Phe rpoC_p.Leu14Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.9820231071276 0.168448731581911 252 4649 False False 0 0 1.9820231071276 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 2.24912710990902 0.180424970179968 177 3890 False False 0 0 0 0 0 0 0 0 0 2.24912710990902 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Leu151Arg rpoC_p.Leu151Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 7 16810 30525 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 1.26007067420399 0.0561478031672613 154 4649 False False 0 0 1.26007067420399 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 7 11502 23700 0 0 0.000320664925697395 0.999704728561184 0.999391723222185 0.999881277590374 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 1.42986888806462 0.104255162462523 134.5 3890 False False 0 0 0 0 0 0 0 0 0 1.42986888806462 0 0 0.000320664925697395 0.999704728561184 0.999391723222185 0.999881277590374 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Leu151Phe rpoC_p.Leu151Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 2.75133392880791 0.304355565478378 305.5 4649 False False 0 0 1.9820231071276 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 10.9713274274722 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Leu240Val rpoC_p.Leu240Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3828 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3210 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Leu293Ile rpoC_p.Leu293Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3668 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3064 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Leu340Met rpoC_p.Leu340Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3743 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3133 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Leu340Phe rpoC_p.Leu340Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3494 4649 False False Inf 1.1990579265185 Inf 0 0 0.000219473678051534 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 11498 23707 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 1 0.999844409142079 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2913 3890 False False 0 0 0 0 0 0 0 Inf 1.3608069907404 Inf 0 0 0.000320776462830572 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Leu343Arg rpoC_p.Leu343Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3756 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Leu360Val rpoC_p.Leu360Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3858 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Leu381Val rpoC_p.Leu381Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Leu39Arg rpoC_p.Leu39Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3611 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Leu405Pro rpoC_p.Leu405Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3384 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2815 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Leu405Val rpoC_p.Leu405Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3385 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2816 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Leu406Phe rpoC_p.Leu406Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 9 0 16801 30532 0.000535395597858417 0.000244845253515427 0.00101610321951737 1 0.999879187193184 1 1 0.663732883120057 1 NA NA NA NA NA NA NA NA NA NA 3577 4649 False False Inf 3.58631764003717 Inf 0 0 0.000219538986540545 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 7 0 11495 23707 0.000608589810467744 0.000244718560881119 0.00125352303681455 1 0.999844409142079 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 2990 3890 False False 0 0 0 0 0 0 0 Inf 2.97179240572548 Inf 0 0 0.000320860166613556 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Leu446Gln rpoC_p.Leu446Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3430 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2855 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Leu446Val rpoC_p.Leu446Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3816 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3200 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Leu449Arg rpoC_p.Leu449Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 15 0 16795 30532 0.000892325996430696 0.000499511372123772 0.00147132963433071 1 0.999879187193184 1 1 0.781980639089466 1 NA NA NA NA NA NA NA NA NA NA 3669 4649 False False Inf 6.51893136980533 Inf 0 0 0.00021961740805081 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 13 0 11489 23707 0.00113023821944009 0.000601937155487611 0.00193196626494298 1 0.999844409142079 1 1 0.752947361999529 1 NA NA NA NA NA NA NA NA NA NA 3065 3890 False False 0 0 0 0 0 0 0 Inf 6.28688570681876 Inf 0 0 0.000321027705298525 1 0.999844409142079 1 3 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Leu449Val rpoC_p.Leu449Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 39 0 16771 30532 0.0023200475907198 0.00165028486749537 0.00317023071319027 1 0.999879187193184 1 1 0.909748899039665 1 NA NA NA NA NA NA NA NA NA NA 3817 4649 False False Inf 18.3463480189943 Inf 0 0 0.000219931655152409 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 33 0 11469 23707 0.00286906624934793 0.00197573107651826 0.0040268977332274 1 0.999844409142079 1 1 0.89423718992542 1 NA NA NA NA NA NA NA NA NA NA 3201 3890 False False 0 0 0 0 0 0 0 Inf 17.4722896658069 Inf 0 0 0.000321587433401291 1 0.999844409142079 1 16 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Leu487Val rpoC_p.Leu487Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3629 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3033 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Leu507Val rpoC_p.Leu507Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 80 0 16730 30532 0.00475907198096371 0.00377539786541648 0.00591962715877449 1 0.999879187193184 1 1 0.954935964932307 1 NA NA NA NA NA NA NA NA NA NA 3578 4649 False False Inf 38.6495209345671 Inf 0 0 0.000220470579466507 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 52 0 11450 23707 0.00452095287776038 0.00337825195874347 0.00592445285331685 1 0.999844409142079 1 1 0.93151779129668 1 NA NA NA NA NA NA NA NA NA NA 2991 3890 False False 0 0 0 0 0 0 0 Inf 28.1780390593965 Inf 0 0 0.000322120985979758 1 0.999844409142079 1 3 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Leu516Pro rpoC_p.Leu516Pro 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 141 0 16669 30532 0.00838786436644854 0.00706503741869211 0.0098847506301255 1 0.999879187193184 1 1 0.974177001336134 1 NA NA NA NA NA NA NA NA NA NA 3648 4649 False False Inf 69.1209047926505 Inf 0 0 0.000221277299563171 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 108 0 11394 23707 0.00938967136150234 0.00770871043504612 0.0113254716383708 1 0.999844409142079 1 1 0.966420449781345 1 NA NA NA NA NA NA NA NA NA NA 3048 3890 False False 0 0 0 0 0 0 0 Inf 59.864925659786 Inf 0 0 0.000323703911667796 1 0.999844409142079 1 13 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Leu516Val rpoC_p.Leu516Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 3 1 16807 30531 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999967247478055 0.999817528289014 0.999999170778282 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 3562 4649 False False 5.44969358005592 0.437509494081317 285.652299683162 0 0 0.000219460621016169 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 2975 3890 False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 0 0 0.000320720684566658 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Leu527Val rpoC_p.Leu527Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 100 0 16710 30532 0.00594883997620464 0.00484275744567048 0.00723072428616067 1 0.999879187193184 1 1 0.963783307354823 1 NA NA NA NA NA NA NA NA NA NA 3630 4649 False False Inf 48.6018487746115 Inf 0 0 0.000220734428951789 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 76 0 11426 23707 0.0066075465136498 0.00520942439563912 0.00826344670543621 1 0.999844409142079 1 1 0.952621246133069 1 NA NA NA NA NA NA NA NA NA NA 3034 3890 False False 0 0 0 0 0 0 0 Inf 41.6924224808634 Inf 0 0 0.000322797483071588 1 0.999844409142079 1 18 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Leu547Trp rpoC_p.Leu547Trp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3690 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3086 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Leu547Val rpoC_p.Leu547Val 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 117 0 16693 30532 0.00696014277215942 0.00575952865737889 0.00833577979395594 1 0.999879187193184 1 1 0.968962968306888 1 NA NA NA NA NA NA NA NA NA NA 3527 4649 False False Inf 57.0495417145276 Inf 0 0 0.000220959198057917 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 98 0 11404 23707 0.00852025734654842 0.00692241470705599 0.0103737773470697 1 0.999844409142079 1 1 0.963058012964807 1 NA NA NA NA NA NA NA NA NA NA 2944 3890 False False 0 0 0 0 0 0 0 Inf 54.1433424522783 Inf 0 0 0.000323420106371545 1 0.999844409142079 1 4 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Leu560Ser rpoC_p.Leu560Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3818 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3202 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Leu566Val rpoC_p.Leu566Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3691 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3087 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 2 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Leu579Val rpoC_p.Leu579Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3373 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Leu627dup rpoC_p.Leu627dup 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3386 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2817 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Leu627Val rpoC_p.Leu627Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Leu637Pro rpoC_p.Leu637Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3449 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2871 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Leu640Arg rpoC_p.Leu640Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3563 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2976 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Leu650Arg rpoC_p.Leu650Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Leu679Arg rpoC_p.Leu679Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Leu679His rpoC_p.Leu679His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3649 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3049 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Leu679Pro rpoC_p.Leu679Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3769 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3157 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Leu679Thr rpoC_p.Leu679Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3744 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3134 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Leu716Phe rpoC_p.Leu716Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3710 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Leu737Arg rpoC_p.Leu737Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 1 4 5 6 16805 30526 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 0.999803484868334 0.999572318737888 0.999927879105266 0.454545454545454 0.167488094063707 0.766206402340654 0.2 0.00505076337946806 0.716417936118089 0.142857142857142 0.00361029686190058 0.578723197043195 0.454120797381731 0.00922500562219136 4.58957179363191 0.661799238617308 929 4649 False False 1.51373599127243 0.36538656529008 5.95429757230108 5.95025586100202e-05 1.50647321873052e-06 0.000331481949204222 0.999803484868334 0.999572318737888 0.999927879105266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3066 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Leu746Val rpoC_p.Leu746Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 20 0 16790 30532 0.00118976799524092 0.000726887900057249 0.00183690503094944 1 0.999879187193184 1 1 0.831566529016914 1 NA NA NA NA NA NA NA NA NA NA 3564 4649 False False Inf 8.97808458256773 Inf 0 0 0.000219682802119661 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 20 0 11482 23707 0.00173882802990784 0.00106243473911297 0.00268420764151461 1 0.999844409142079 1 1 0.831566529016914 1 NA NA NA NA NA NA NA NA NA NA 2977 3890 False False 0 0 0 0 0 0 0 Inf 10.1895239484777 Inf 0 0 0.00032122338836531 1 0.999844409142079 1 2 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Leu774Arg rpoC_p.Leu774Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3876 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3253 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Leu774Val rpoC_p.Leu774Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3692 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3088 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Leu789Ala rpoC_p.Leu789Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 9 0 9 0 10 16810 30522 0 0 0.000219421459229958 0.999672474780558 0.999397752220648 0.999842928110511 0 0 0.30849710781876 0 0 0.336267116879942 0 0 0.30849710781876 0 0 0.920047965941321 0.0314970755483781 129 4649 False False 0 0 0.81016282812198 0 0 0.000219421459229958 0.999672474780558 0.999397752220648 0.999842928110511 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 0 10 11502 23697 0 0 0.000320664925697395 0.999578183658835 0.999224402000993 0.999797704727851 0 0 0.30849710781876 0 0 0.336267116879942 0 0 0.30849710781876 0 0 1.04401040953349 0.0357305264575981 100 3890 False False 0 0 0 0 0 0 0 0 0 0.919347572200535 0 0 0.000320664925697395 0.999578183658835 0.999224402000993 0.999797704727851 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Leu789Val rpoC_p.Leu789Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3495 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2914 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Leu823Pro rpoC_p.Leu823Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3650 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3050 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Leu847Arg rpoC_p.Leu847Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3465 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2884 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Leu847Met rpoC_p.Leu847Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3374 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2806 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Leu97Phe rpoC_p.Leu97Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3670 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3067 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Lys1082Glu rpoC_p.Lys1082Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0465715996825058 Inf 0.355075831185839 416 4649 False False Inf 0.0465715996825058 Inf 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0528490600080728 Inf 0.32667783805277 340.5 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Lys1090Glu rpoC_p.Lys1090Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3799 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3184 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Lys1152Arg rpoC_p.Lys1152Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3779 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Lys1152Asn rpoC_p.Lys1152Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 17 0 16793 30532 0.00101130279595478 0.000589228022589122 0.0016187015795436 1 0.999879187193184 1 1 0.804935677030906 1 NA NA NA NA NA NA NA NA NA NA 3528 4649 False False Inf 7.50125453808733 Inf 0 0 0.000219643561005912 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 17 0 11485 23707 0.00147800382542166 0.000861220016155565 0.00236537605429428 1 0.999844409142079 1 1 0.804935677030906 1 NA NA NA NA NA NA NA NA NA NA 2945 3890 False False 0 0 0 0 0 0 0 Inf 8.51620393516598 Inf 0 0 0.000321139494990277 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Lys1152Gln rpoC_p.Lys1152Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3780 4649 False False Inf 1.1990579265185 Inf 0 0 0.000219473678051534 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3166 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Lys1152Thr rpoC_p.Lys1152Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3612 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3017 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 2 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Lys1244_Leu1245insGln rpoC_p.Lys1244_Leu1245insGln 2 inframe_insertion (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3845 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3226 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Lys1244Glu rpoC_p.Lys1244Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3544 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2959 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Lys1256Glu rpoC_p.Lys1256Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3732 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3123 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Lys228Asn rpoC_p.Lys228Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Lys232Thr rpoC_p.Lys232Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Lys445Arg rpoC_p.Lys445Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 69 0 16741 30532 0.0041046995835812 0.00319506284544273 0.00519192695325037 1 0.999879187193184 1 1 0.94794194213692 1 NA NA NA NA NA NA NA NA NA NA 3595 4649 False False Inf 33.1804124052076 Inf 0 0 0.00022032573093953 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 46 0 11456 23707 0.00399930446878803 0.00292943659823562 0.00533094854709251 1 0.999844409142079 1 1 0.922938172948099 1 NA NA NA NA NA NA NA NA NA NA 3004 3890 False False 0 0 0 0 0 0 0 Inf 24.7752879195901 Inf 0 0 0.000321952304523779 1 0.999844409142079 1 18 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Lys445Glu rpoC_p.Lys445Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3671 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3068 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Lys691Asn rpoC_p.Lys691Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3711 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3107 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Lys715Thr rpoC_p.Lys715Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 7 0 16803 30532 0.000416418798334324 0.000167437820935922 0.000857792460925722 1 0.999879187193184 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 3565 4649 False False Inf 2.61832748907777 Inf 0 0 0.000219512858481393 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 5 0 11497 23707 0.00043470700747696 0.000141162766530747 0.00101416710312943 1 0.999844409142079 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 2978 3890 False False 0 0 0 0 0 0 0 Inf 1.88913119689894 Inf 0 0 0.000320804359238686 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Lys717Met rpoC_p.Lys717Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3846 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3227 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Lys717Thr rpoC_p.Lys717Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3829 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3211 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Lys71Asn rpoC_p.Lys71Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3431 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2856 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Lys779Thr rpoC_p.Lys779Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Lys828Arg rpoC_p.Lys828Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Lys837Thr rpoC_p.Lys837Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3529 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2946 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Lys86Asn rpoC_p.Lys86Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3496 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2915 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Lys987Glu rpoC_p.Lys987Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Met1161Ile rpoC_p.Met1161Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Met1208Ile rpoC_p.Met1208Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Met1208Thr rpoC_p.Met1208Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3672 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3069 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Met1208Val rpoC_p.Met1208Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Met205Arg rpoC_p.Met205Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3651 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3051 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Met205Val rpoC_p.Met205Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3579 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2992 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Met256Val rpoC_p.Met256Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3387 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2818 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Met310Ile rpoC_p.Met310Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3847 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3228 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Met447Ile rpoC_p.Met447Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3631 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3035 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Met447Thr rpoC_p.Met447Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Met515Gln rpoC_p.Met515Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3781 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3167 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Met515Ile rpoC_p.Met515Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 14 16810 30518 0 0 0.000219421459229958 0.999541464692781 0.999230775228684 0.999749292529582 0 0 0.231635761650116 0 0 0.707598226178713 0 0 0.231635761650116 0 0 4.39396870183304 0.556939796013511 926 4649 False False 0 0 0.547412779991011 0 0 0.000219421459229958 0.999541464692781 0.999230775228684 0.999749292529582 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 0 0 0.975 0 0 0.521823750104981 0 0 80.2705613703955 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 2.24912710990902 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Met515Thr rpoC_p.Met515Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3530 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2947 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 4 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Met541Ile rpoC_p.Met541Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3596 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Met541Thr rpoC_p.Met541Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3673 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3070 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Met559Ile rpoC_p.Met559Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.75142405620251 0.304356294847217 327.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12235036001139 0.310791984491028 261 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Met581Ile rpoC_p.Met581Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Met663Ile rpoC_p.Met663Ile 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 9 27 16801 30505 0.000535395597858417 0.000244845253515427 0.00101610321951737 0.999115681907506 0.998713622442022 0.999417150456935 0.25 0.121203294123835 0.422029584578144 NA NA NA 0 0 0.127702867615432 NA NA NA NA 3770 4649 False False 0.605221911394163 0.250363717294188 1.32618317619805 0 0 0.000219538986540545 0.999115681907506 0.998713622442022 0.999417150456935 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 12 11501 23695 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999493820390602 0.999115973206486 0.999738423129043 0.0769230769230769 0.00194562849734675 0.360297435267877 NA NA NA 0 0 0.264648469397051 NA NA NA NA 3158 3890 False False 0 0 0 0 0 0 0 0.171687969162101 0.00401993268933778 1.16069064496843 0 0 0.000320692802708327 0.999493820390602 0.999115973206486 0.999738423129043 14 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Met672Leu rpoC_p.Met672Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3432 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2857 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Met733Ile rpoC_p.Met733Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Met733Lys rpoC_p.Met733Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3652 4649 False False Inf 1.1990579265185 Inf 0 0 0.000219473678051534 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3052 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Met92Thr rpoC_p.Met92Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 17 0 17 5 35 16805 30497 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 0.998853661731953 0.99840607808452 0.999201407537638 0.125 0.0418596261386167 0.26803291736172 0 0 0.195064322969093 0 0 0.100032435572105 0 0 0.439864006415835 0.000678921934993609 63 4649 True False 0.259251073235006 0.0792496663466721 0.664702862145873 0 0 0.000219486736640675 0.998853661731953 0.99840607808452 0.999201407537638 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 16 0 16 5 32 11497 23675 0.00043470700747696 0.000141162766530747 0.00101416710312943 0.998650187708272 0.998094997333691 0.999076551872477 0.135135135135135 0.0453719923419939 0.287747797310572 0 0 0.205907214207822 0 0 0.108881160679352 0 0 0.534071310752798 0.00242305495699292 57 3890 False False 0 0 0 0 0 0 0 0.321755131773506 0.097847799637449 0.832250008767108 0 0 0.000320804359238686 0.998650187708272 0.998094997333691 0.999076551872477 1 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Met983Ile rpoC_p.Met983Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 7 0 16803 30532 0.000416418798334324 0.000167437820935922 0.000857792460925722 1 0.999879187193184 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 3745 4649 False False Inf 2.61832748907777 Inf 0 0 0.000219512858481393 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 7 0 11495 23707 0.000608589810467744 0.000244718560881119 0.00125352303681455 1 0.999844409142079 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 3135 3890 False False 0 0 0 0 0 0 0 Inf 2.97179240572548 Inf 0 0 0.000320860166613556 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Met983Val rpoC_p.Met983Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3800 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3185 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Phe1061Leu rpoC_p.Phe1061Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 4 4 16806 30528 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999868989912223 0.999664596427238 0.999964303043777 0.5 0.157012770487058 0.842987229512941 0 0 0.975 0 0 0.602364635616474 0 0 70.7683587068428 1 1627.5 4649 False False 1.81649410924669 0.338292932357021 9.7540407308173 0 0 0.000219473678051534 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 3 11498 23704 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 0.99987345509765 0.999630227076139 0.999973902638554 0.571428571428571 0.184051567640083 0.901011721557492 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2899 3890 False False 0 0 0 0 0 0 0 2.74876790166405 0.464911430750807 18.766829223129 0 0 0.000320776462830572 0.99987345509765 0.999630227076139 0.999973902638554 1 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Phe1175Cys rpoC_p.Phe1175Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3848 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3229 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Phe1175Leu rpoC_p.Phe1175Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Phe252Leu rpoC_p.Phe252Leu 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 3 16808 30529 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999901742434167 0.999712876815577 0.99997973646933 0.4 0.0527449505263169 0.853367200365326 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3819 4649 False False 1.21089163890211 0.101157890363798 10.5697741171107 0 0 0.000219447565534303 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3203 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Phe452Cys rpoC_p.Phe452Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 38 0 16772 30532 0.00226055919095776 0.00160018760749268 0.00310148712776189 1 0.999879187193184 1 1 0.907487238584121 1 NA NA NA NA NA NA NA NA NA NA 3481 4649 False False Inf 17.8567316417957 Inf 0 0 0.000219918543569422 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 28 0 11474 23707 0.00243435924187097 0.00161820482579939 0.00351641960825614 1 0.999844409142079 1 1 0.876563881499736 1 NA NA NA NA NA NA NA NA NA NA 2900 3890 False False 0 0 0 0 0 0 0 Inf 14.6694724449369 Inf 0 0 0.000321447318471383 1 0.999844409142079 1 8 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Phe452Leu rpoC_p.Phe452Leu 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 57 0 16753 30532 0.00339083878643664 0.0025691692652669 0.00439102203662388 1 0.999879187193184 1 1 0.937332519085515 1 NA NA NA NA NA NA NA NA NA NA 3674 4649 False False Inf 27.237920186879 Inf 0 0 0.000220167931279891 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 26 0 11476 23707 0.00226047643888019 0.00147713322194328 0.00331037981655982 1 0.999844409142079 1 1 0.867725395502245 1 NA NA NA NA NA NA NA NA NA NA 3071 3890 False False 0 0 0 0 0 0 0 Inf 13.550678341775 Inf 0 0 0.00032139130668021 1 0.999844409142079 1 10 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Phe452Ser rpoC_p.Phe452Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 133 0 16677 30532 0.00791195716835217 0.006628593640724 0.0093696871925254 1 0.999879187193184 1 1 0.972645173715956 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.343831207800867 Inf 0.124806377562957 218 4649 False False Inf 65.0585499438714 Inf 0.000119911265663409 1.45221404777858e-05 0.000433092882759177 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 124 0 11378 23707 0.0107807337854286 0.00897462517736371 0.0128404426969541 1 0.999844409142079 1 1 0.970689118910225 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.391241566576921 Inf 0.105188015956447 145 3890 False False 0 0 0 0 0 0 0 Inf 69.0119640814227 Inf 0.000175746924428822 2.12844765709076e-05 0.000634712600152043 1 0.999844409142079 1 27 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Phe512Val rpoC_p.Phe512Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Phe683Val rpoC_p.Phe683Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3733 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3124 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Phe831Leu rpoC_p.Phe831Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 34 2 16776 30530 0.00202260559190957 0.00140110733425029 0.00282525244033458 0.999934494956111 0.999763393503742 0.99999206693684 0.944444444444444 0.813363293542446 0.993199699345977 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3693 4649 False False 30.9376490224129 7.9288480960248 263.797294359126 0 0 0.000219866112867115 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 21 0 11481 23707 0.00182576943140323 0.00113052422891288 0.00278953561568501 1 0.999844409142079 1 1 0.83890238478092 1 NA NA NA NA NA NA NA NA NA NA 3089 3890 False False 0 0 0 0 0 0 0 Inf 10.7499748703754 Inf 0 0 0.000321251362564953 1 0.999844409142079 1 8 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Phe831Ser rpoC_p.Phe831Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3712 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3108 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Phe831Tyr rpoC_p.Phe831Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3653 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3053 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Pro1040Ala rpoC_p.Pro1040Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 83 0 16727 30532 0.00493753718024985 0.0039345826136468 0.00611719598293536 1 0.999879187193184 1 1 0.956528847833558 1 NA NA NA NA NA NA NA NA NA NA 3580 4649 False False Inf 40.1482295183914 Inf 0 0 0.000220510116670372 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 37 0 11465 23707 0.0032168318553295 0.00226592712135244 0.00443127959617942 1 0.999844409142079 1 1 0.90510941258501 1 NA NA NA NA NA NA NA NA NA NA 2993 3890 False False 0 0 0 0 0 0 0 Inf 19.7150797190654 Inf 0 0 0.000321699613322993 1 0.999844409142079 1 7 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Pro1040Arg rpoC_p.Pro1040Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 337 1 16473 30531 0.0200475907198096 0.017982364140403 0.0222811313653648 0.999967247478055 0.999817528289014 0.999999170778282 0.997041420118343 0.983626895795636 0.999925098047941 1 0.158113883008419 1 0.666666666666666 0.0942993240502461 0.991596241340387 Inf 0.348078775411684 Inf 0.122836414616817 217 4649 False False 624.594609360772 111.656305083793 16383.9999999403 0.000121396054628224 1.47019635305575e-05 0.000438454760683606 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 133 0 11369 23707 0.0115632063988871 0.00969034967883292 0.0136890092786052 1 0.999844409142079 1 1 0.972645173715956 1 NA NA NA NA NA NA NA NA NA NA 3145 3890 False False 0 0 0 0 0 0 0 Inf 74.2246128944899 Inf 0 0 0.000324415608823866 1 0.999844409142079 1 116 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Pro1040Gln rpoC_p.Pro1040Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 11 0 16799 30532 0.00065437239738251 0.000326704163498642 0.00117055062018267 1 0.999879187193184 1 1 0.715085847081845 1 NA NA NA NA NA NA NA NA NA NA 3482 4649 False False Inf 4.56066720991606 Inf 0 0 0.000219565120820351 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 11 0 11491 23707 0.000956355416449313 0.000477502787107626 0.00171053820723243 1 0.999844409142079 1 1 0.715085847081845 1 NA NA NA NA NA NA NA NA NA NA 2901 3890 False False 0 0 0 0 0 0 0 Inf 5.1761760609822 Inf 0 0 0.000320971839633333 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Pro1040Leu rpoC_p.Pro1040Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 30 0 16780 30532 0.00178465199286139 0.00120441111287972 0.00254672951354614 1 0.999879187193184 1 1 0.884296691777972 1 NA NA NA NA NA NA NA NA NA NA 3505 4649 False False Inf 13.9032074890251 Inf 0 0 0.000219813707158818 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 22 0 11480 23707 0.00191271083289862 0.00119906180010764 0.00289444346770694 1 0.999844409142079 1 1 0.845627487184425 1 NA NA NA NA NA NA NA NA NA NA 2924 3890 False False 0 0 0 0 0 0 0 Inf 11.3088830935203 Inf 0 0 0.000321279341637369 1 0.999844409142079 1 19 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Pro1040Ser rpoC_p.Pro1040Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 93 0 16717 30532 0.00553242117787031 0.00446763143571955 0.00677336617877988 1 0.999879187193184 1 1 0.961111001465724 1 NA NA NA NA NA NA NA NA NA NA 3466 4649 False False Inf 45.1488074071835 Inf 0 0 0.000220642009825833 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 59 0 11443 23707 0.00512954268822813 0.00390707073547343 0.00661181251893642 1 0.999844409142079 1 1 0.93939109904966 1 NA NA NA NA NA NA NA NA NA NA 2885 3890 False False 0 0 0 0 0 0 0 Inf 32.0975626940034 Inf 0 0 0.000322318004547786 1 0.999844409142079 1 17 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Pro1040Thr rpoC_p.Pro1040Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 15 0 16795 30532 0.000892325996430696 0.000499511372123772 0.00147132963433071 1 0.999879187193184 1 1 0.781980639089466 1 NA NA NA NA NA NA NA NA NA NA 3415 4649 False False Inf 6.51893136980533 Inf 0 0 0.00021961740805081 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 14 0 11488 23707 0.00121717962093548 0.000665598145642159 0.00204137811638842 1 0.999844409142079 1 1 0.768364238349883 1 NA NA NA NA NA NA NA NA NA NA 2842 3890 False False 0 0 0 0 0 0 0 Inf 6.84328477771802 Inf 0 0 0.000321055645424387 1 0.999844409142079 1 3 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Pro1118Leu rpoC_p.Pro1118Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3450 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2872 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Pro1127Leu rpoC_p.Pro1127Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3433 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Pro1200Arg rpoC_p.Pro1200Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Pro1200Leu rpoC_p.Pro1200Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Pro1200Ser rpoC_p.Pro1200Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3451 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2873 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Pro1259Leu rpoC_p.Pro1259Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3782 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3168 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Pro1259Ser rpoC_p.Pro1259Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3467 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2886 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Pro1306Ala rpoC_p.Pro1306Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3801 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3186 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Pro231Leu rpoC_p.Pro231Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3877 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3254 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Pro318Ser rpoC_p.Pro318Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Pro322Ser rpoC_p.Pro322Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 5 0 16805 30532 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 1 0.999879187193184 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 3830 4649 False False Inf 1.66460481015123 Inf 0 0 0.000219486736640675 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3212 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 4 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Pro390Leu rpoC_p.Pro390Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3878 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3255 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Pro394Gln rpoC_p.Pro394Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3581 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2994 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Pro434Ala rpoC_p.Pro434Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 6 0 16804 30532 0.000356930398572278 0.000130998068917797 0.000776724091447791 1 0.999879187193184 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 3613 4649 False False Inf 2.13890645017026 Inf 0 0 0.000219499796783869 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 5 0 11497 23707 0.00043470700747696 0.000141162766530747 0.00101416710312943 1 0.999844409142079 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 3018 3890 False False 0 0 0 0 0 0 0 Inf 1.88913119689894 Inf 0 0 0.000320804359238686 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Pro434Arg rpoC_p.Pro434Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 25 0 16785 30532 0.00148720999405116 0.000962667916776425 0.00219463783814356 1 0.999879187193184 1 1 0.862814828469287 1 NA NA NA NA NA NA NA NA NA NA 3879 4649 False False Inf 11.4381466207495 Inf 0 0 0.000219748235144057 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 17 0 11485 23707 0.00147800382542166 0.000861220016155565 0.00236537605429428 1 0.999844409142079 1 1 0.804935677030906 1 NA NA NA NA NA NA NA NA NA NA 3256 3890 False False 0 0 0 0 0 0 0 Inf 8.51620393516598 Inf 0 0 0.000321139494990277 1 0.999844409142079 1 4 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Pro434Gln rpoC_p.Pro434Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 22 0 16788 30532 0.00130874479476502 0.000820359439669085 0.00198078881845282 1 0.999879187193184 1 1 0.845627487184425 1 NA NA NA NA NA NA NA NA NA NA 3783 4649 False False Inf 9.95930561201006 Inf 0 0 0.000219708970652805 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 12 0 11490 23707 0.0010432968179447 0.000539199208333142 0.00182171963730016 1 0.999844409142079 1 1 0.735351530602948 1 NA NA NA NA NA NA NA NA NA NA 3169 3890 False False 0 0 0 0 0 0 0 Inf 5.7314630344545 Inf 0 0 0.000320999770035263 1 0.999844409142079 1 2 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Pro434Leu rpoC_p.Pro434Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3859 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3239 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 5 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Pro434Ser rpoC_p.Pro434Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3654 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3054 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Pro434Thr rpoC_p.Pro434Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 14 0 16796 30532 0.000832837596668649 0.000455392489979272 0.00139696554892221 1 0.999879187193184 1 1 0.768364238349883 1 NA NA NA NA NA NA NA NA NA NA 3694 4649 False False Inf 6.02871753174659 Inf 0 0 0.000219604333908644 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 6 0 11496 23707 0.000521648408972352 0.000191459062774625 0.00113506056981396 1 0.999844409142079 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 3090 3890 False False 0 0 0 0 0 0 0 Inf 2.42738974088595 Inf 0 0 0.000320832260499258 1 0.999844409142079 1 3 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Pro434Val rpoC_p.Pro434Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 7 0 16803 30532 0.000416418798334324 0.000167437820935922 0.000857792460925722 1 0.999879187193184 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 3675 4649 False False Inf 2.61832748907777 Inf 0 0 0.000219512858481393 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 5 0 11497 23707 0.00043470700747696 0.000141162766530747 0.00101416710312943 1 0.999844409142079 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 3072 3890 False False 0 0 0 0 0 0 0 Inf 1.88913119689894 Inf 0 0 0.000320804359238686 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Pro444Ser rpoC_p.Pro444Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3416 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2843 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Pro481Ala rpoC_p.Pro481Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3597 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3005 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Pro481Leu rpoC_p.Pro481Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3784 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Pro481Ser rpoC_p.Pro481Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3655 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3055 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Pro481Thr rpoC_p.Pro481Thr 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 75 17 16735 30515 0.00446162998215348 0.00351092383353281 0.00558952676003888 0.999443207126948 0.999108669858669 0.999675615241488 0.815217391304347 0.720712758560675 0.888512333632486 NA NA NA 0 0 0.195064322969093 NA NA NA NA 3388 4649 False False 8.04451747833881 4.70344811767242 14.538295186705 0 0 0.000220404715623871 0.999443207126948 0.999108669858669 0.999675615241488 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 69 14 11433 23693 0.00599895670318205 0.00467045641118006 0.00758601061800012 0.999409457122369 0.999009367705732 0.999677108302285 0.831325301204819 0.733216064154949 0.90460037068093 NA NA NA 0 0 0.231635761650116 NA NA NA NA 2819 3890 False False 0 0 0 0 0 0 0 10.2136484612212 5.69212002254926 19.6563025014843 0 0 0.000322599878079741 0.999409457122369 0.999009367705732 0.999677108302285 8 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Pro495Ala rpoC_p.Pro495Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3880 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3257 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 2 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Pro514Leu rpoC_p.Pro514Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Pro601Gln rpoC_p.Pro601Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Pro601Leu rpoC_p.Pro601Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 230 2138 16580 28394 0.0136823319452706 0.011981007193221 0.0155548353718213 0.929975108083322 0.927055194329064 0.932812888975391 0.0971283783783783 0.085493764467811 0.109770104897612 NA NA NA 0 0 0.00172390033185553 NA NA NA NA NA NA False True 0.184230778344867 0.159863789776369 0.211472256028124 0 0 0.000222464964757515 0.929975108083322 0.927055194329064 0.932812888975391 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 172 1634 11330 22073 0.0149539210572074 0.0128158454398996 0.0173423505526217 0.931075209853629 0.927776245867358 0.934268012926472 0.0952380952380952 0.0820888301975798 0.109718430507388 NA NA NA 0 0 0.00225502975683479 NA NA NA NA NA NA False True 0 1 1 0 0 1 1 0.205072699400752 0.173959571138649 0.240518681489798 0 0 0.000325532126844237 0.931075209853629 0.927776245867358 0.934268012926472 201 Not assoc w R 5) Not assoc w R No change yes 1 +Rifampicin rpoC p.Pro643Leu rpoC_p.Pro643Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3400 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2828 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Pro643Ser rpoC_p.Pro643Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 80.2910622977969 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Pro658Leu rpoC_p.Pro658Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Pro682Leu rpoC_p.Pro682Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Pro682Ser rpoC_p.Pro682Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3734 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3125 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Pro705Leu rpoC_p.Pro705Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3632 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3036 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Pro739Ser rpoC_p.Pro739Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3389 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Pro739Thr rpoC_p.Pro739Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0465715996825058 Inf 0.355075831185839 416 4649 False False Inf 0.0465715996825058 Inf 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Pro740dup rpoC_p.Pro740dup 2 inframe_insertion (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3434 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2858 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Pro833Leu rpoC_p.Pro833Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3746 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3136 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Pro906Ala rpoC_p.Pro906Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 159 266 16651 30266 0.00945865556216537 0.00805103726054839 0.0110396818233516 0.991287829162845 0.990180946917286 0.992299647454831 0.374117647058823 0.327953231814758 0.422047903495979 NA NA NA 0 0 0.0137722505851113 NA NA NA NA NA NA False True 1.08650116071513 0.886168315415012 1.32862109255337 0 0 0.000221516477402969 0.991287829162845 0.990180946917286 0.992299647454831 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 135 249 11367 23458 0.0117370892018779 0.00984971945380535 0.0138772632317877 0.98949677310499 0.988116186301821 0.990755291687082 0.3515625 0.303812051548304 0.401621509446931 NA NA NA 0 0 0.0147055780339792 NA NA NA NA NA NA False True 0 1 1 0 0 1 0 1.11886977840101 0.899471585535101 1.38690442655766 0 0 0.000324472679813772 0.98949677310499 0.988116186301821 0.990755291687082 7 Not assoc w R 5) Not assoc w R No change yes 1 +Rifampicin rpoC p.Pro906Arg rpoC_p.Pro906Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Pro906His rpoC_p.Pro906His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Pro914Leu rpoC_p.Pro914Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Pro947Ser rpoC_p.Pro947Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3713 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3109 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ser1095Phe rpoC_p.Ser1095Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3676 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3073 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ser1095Tyr rpoC_p.Ser1095Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3714 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3110 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ser1100Ala rpoC_p.Ser1100Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 9 1 8 11 11 16799 30521 0.00065437239738251 0.000326704163498642 0.00117055062018267 0.999639722258614 0.999355455254591 0.999820137367966 0.5 0.282210520938092 0.717789479061907 0.111111111111111 0.00280913674659921 0.482496514917337 0.0833333333333333 0.00210759323186022 0.384796165150944 0.227104291922138 0.00512186374404727 1.694259390968 0.172316623277719 285 4649 False False 1.8168343353771 0.714139898891481 4.62211031290046 5.95238095238095e-05 1.50701124447466e-06 0.000331600319507222 0.999639722258614 0.999355455254591 0.999820137367966 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 1 7 11 9 11491 23698 0.000956355416449313 0.000477502787107626 0.00171053820723243 0.999620365292951 0.999279457952852 0.99982639261309 0.55 0.315278133040548 0.769422103224075 0.125 0.0031597235312519 0.526509670875206 0.1 0.00252857854446178 0.445016117028195 0.294615661946616 0.0065403949962044 2.29384705235376 0.451269336519835 360 3890 False False 0 0 0 0 0 0 0 2.52060066332105 0.949264405347276 6.88450041856125 8.70170553428472e-05 2.20307867174715e-06 0.000484731577351791 0.999620365292951 0.999279457952852 0.99982639261309 6 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ser1115Leu rpoC_p.Ser1115Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3545 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2960 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ser1172Ala rpoC_p.Ser1172Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3435 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2859 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ser1242Arg rpoC_p.Ser1242Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3771 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3159 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ser1242Asn rpoC_p.Ser1242Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.75142405620251 0.304356294847217 327.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12235036001139 0.310791984491028 261 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ser1287Gln rpoC_p.Ser1287Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ser1294Asn rpoC_p.Ser1294Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 70.7515377372301 1 1627.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 80.2773259044493 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ser260Ala rpoC_p.Ser260Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3849 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3230 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ser308Phe rpoC_p.Ser308Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ser403Ala rpoC_p.Ser403Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3695 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3091 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ser403Cys rpoC_p.Ser403Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ser428Ala rpoC_p.Ser428Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 31 0 16779 30532 0.00184414039262343 0.00125333722248032 0.00261659758042388 1 0.999879187193184 1 1 0.88781125307763 1 NA NA NA NA NA NA NA NA NA NA 3860 4649 False False Inf 14.3908106225041 Inf 0 0 0.000219826806243681 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 21 0 11481 23707 0.00182576943140323 0.00113052422891288 0.00278953561568501 1 0.999844409142079 1 1 0.83890238478092 1 NA NA NA NA NA NA NA NA NA NA 3240 3890 False False 0 0 0 0 0 0 0 Inf 10.7499748703754 Inf 0 0 0.000321251362564953 1 0.999844409142079 1 9 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ser548Arg rpoC_p.Ser548Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3785 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3170 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ser561Pro rpoC_p.Ser561Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 32 0 16778 30532 0.00190362879238548 0.0013024338261299 0.00268630258659741 1 0.999879187193184 1 1 0.891118839320647 1 NA NA NA NA NA NA NA NA NA NA 3786 4649 False False Inf 14.8910918616325 Inf 0 0 0.000219839906889832 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 18 0 11484 23707 0.00156494522691705 0.000927741172595553 0.00247216477869727 1 0.999844409142079 1 1 0.814698031862147 1 NA NA NA NA NA NA NA NA NA NA 3171 3890 False False 0 0 0 0 0 0 0 Inf 9.07265194886324 Inf 0 0 0.000321167454579243 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ser613Phe rpoC_p.Ser613Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3820 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3204 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ser614Leu rpoC_p.Ser614Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Ser654Asn rpoC_p.Ser654Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3715 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3111 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ser839Ala rpoC_p.Ser839Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3375 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2807 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Ser839Cys rpoC_p.Ser839Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 5 4 16805 30528 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 0.999868989912223 0.999664596427238 0.999964303043777 0.555555555555555 0.212008506778868 0.863004337734833 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3861 4649 False False 2.27075275215709 0.488655453172155 11.44624379658 0 0 0.000219486736640675 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 5 3 11497 23704 0.00043470700747696 0.000141162766530747 0.00101416710312943 0.99987345509765 0.999630227076139 0.999973902638554 0.625 0.244863216366551 0.914766585862746 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3241 3890 False False 0 0 0 0 0 0 0 3.43625873416253 0.668393407932569 22.1300557847574 0 0 0.000320804359238686 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Thr1025Ile rpoC_p.Thr1025Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3716 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3112 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Thr102Ile rpoC_p.Thr102Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Thr1173Met rpoC_p.Thr1173Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Thr1217Ala rpoC_p.Thr1217Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3821 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3205 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Thr1230Ile rpoC_p.Thr1230Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 18 0 16792 30532 0.00107079119571683 0.000634738299600123 0.00169178580899694 1 0.999879187193184 1 1 0.814698031862147 1 NA NA NA NA NA NA NA NA NA NA 3531 4649 False False Inf 7.99147236998928 Inf 0 0 0.000219656639819404 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 8 0 11494 23707 0.000695531211963136 0.000300327312744212 0.00137001129783907 1 0.999844409142079 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 2948 3890 False False 0 0 0 0 0 0 0 Inf 3.51981666109462 Inf 0 0 0.000320888077582845 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Thr1234Ala rpoC_p.Thr1234Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3566 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2979 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Thr1284Ala rpoC_p.Thr1284Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Thr16Ala rpoC_p.Thr16Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 80.2910622977969 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Thr16Ser rpoC_p.Thr16Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3614 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3019 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Thr225Asn rpoC_p.Thr225Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 13 0 13 1 14 16809 30518 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999541464692781 0.999230775228684 0.999749292529582 0.0666666666666666 0.0016864302413527 0.319484566578303 0 0 0.24705263800047 0 0 0.231635761650116 0 0 0.595821578065095 0.00617858135160112 98 4649 False False 0.129683927827779 0.00307091319956987 0.852531396269756 0 0 0.000219434511605659 0.999541464692781 0.999230775228684 0.999749292529582 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12235036001139 0.310791984491028 261 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 3 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Thr227Ile rpoC_p.Thr227Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 7 16810 30525 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 3615 4649 False False 0 0 1.26007067420399 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 7 11502 23700 0 0 0.000320664925697395 0.999704728561184 0.999391723222185 0.999881277590374 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 3020 3890 False False 0 0 0 0 0 0 0 0 0 1.42986888806462 0 0 0.000320664925697395 0.999704728561184 0.999391723222185 0.999881277590374 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Thr253Ile rpoC_p.Thr253Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Thr596Ala rpoC_p.Thr596Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.81634838479386 0.0231376410853604 142.42572627634 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 2.06121206851578 0.0262561678399451 161.601678830082 0.54664351365823 365.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Thr638Asp rpoC_p.Thr638Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3582 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2995 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Thr638Ile rpoC_p.Thr638Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3546 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2961 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Thr666Ser rpoC_p.Thr666Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3787 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3172 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Thr667Met rpoC_p.Thr667Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 3 41 16807 30491 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.998657146600288 0.998178703998069 0.999036178211222 0.0681818181818181 0.0142876684269753 0.186562010072022 0 0 0.409616397225003 0 0 0.0860438362940284 0 0 1.2588918945206 0.0560727707865562 143 4649 False False 0.132745212143024 0.0262931847268719 0.416198421183876 0 0 0.000219460621016169 0.998657146600288 0.998178703998069 0.999036178211222 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 3 32 11499 23675 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.998650187708272 0.998094997333691 0.999076551872477 0.0857142857142857 0.0180376398142174 0.230575018658877 0 0 0.409616397225003 0 0 0.108881160679352 0 0 1.4287697959021 0.104236058137006 128 3890 False False 0 0 0 0 0 0 0 0.193019501695799 0.0378139637808907 0.617204381465597 0 0 0.000320748571273651 0.998650187708272 0.998094997333691 0.999076551872477 3 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Thr812Ala rpoC_p.Thr812Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3598 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3006 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Thr812Ile rpoC_p.Thr812Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 39 0 16771 30532 0.0023200475907198 0.00165028486749537 0.00317023071319027 1 0.999879187193184 1 1 0.909748899039665 1 NA NA NA NA NA NA NA NA NA NA 3506 4649 False False Inf 18.3463480189943 Inf 0 0 0.000219931655152409 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 18 0 11484 23707 0.00156494522691705 0.000927741172595553 0.00247216477869727 1 0.999844409142079 1 1 0.814698031862147 1 NA NA NA NA NA NA NA NA NA NA 2925 3890 False False 0 0 0 0 0 0 0 Inf 9.07265194886324 Inf 0 0 0.000321167454579243 1 0.999844409142079 1 6 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Thr814Ile rpoC_p.Thr814Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3583 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2996 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Thr825Ala rpoC_p.Thr825Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 10 0 16800 30532 0.000594883997620464 0.000285305684944214 0.00109373983334496 1 0.999879187193184 1 1 0.691502892181239 1 NA NA NA NA NA NA NA NA NA NA 3497 4649 False False Inf 4.07313735951873 Inf 0 0 0.000219552052902727 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 7 0 11495 23707 0.000608589810467744 0.000244718560881119 0.00125352303681455 1 0.999844409142079 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 2916 3890 False False 0 0 0 0 0 0 0 Inf 2.97179240572548 Inf 0 0 0.000320860166613556 1 0.999844409142079 1 2 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Thr825Asn rpoC_p.Thr825Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 6 0 16804 30532 0.000356930398572278 0.000130998068917797 0.000776724091447791 1 0.999879187193184 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 3656 4649 False False Inf 2.13890645017026 Inf 0 0 0.000219499796783869 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 11498 23707 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 1 0.999844409142079 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3056 3890 False False 0 0 0 0 0 0 0 Inf 1.3608069907404 Inf 0 0 0.000320776462830572 1 0.999844409142079 1 4 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Thr825Ser rpoC_p.Thr825Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3436 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2860 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Thr83Ala rpoC_p.Thr83Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3401 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2829 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Thr845Pro rpoC_p.Thr845Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 2 16808 30530 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999934494956111 0.999763393503742 0.99999206693684 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3717 4649 False False 1.8163969538315 0.131636449523742 25.0652602654423 0 0 0.000219447565534303 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 2 11500 23705 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999915636731767 0.999695284447545 0.999989783053538 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3113 3890 False False 0 0 0 0 0 0 0 2.06130434782608 0.149383229063395 28.4413197127326 0 0 0.000320720684566658 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Thr853Ala rpoC_p.Thr853Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 11 0 16799 30532 0.00065437239738251 0.000326704163498642 0.00117055062018267 1 0.999879187193184 1 1 0.715085847081845 1 NA NA NA NA NA NA NA NA NA NA 3507 4649 False False Inf 4.56066720991606 Inf 0 0 0.000219565120820351 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 7 0 11495 23707 0.000608589810467744 0.000244718560881119 0.00125352303681455 1 0.999844409142079 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 2926 3890 False False 0 0 0 0 0 0 0 Inf 2.97179240572548 Inf 0 0 0.000320860166613556 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Thr853Ser rpoC_p.Thr853Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 5 0 16805 30532 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 1 0.999879187193184 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 3696 4649 False False Inf 1.66460481015123 Inf 0 0 0.000219486736640675 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 11498 23707 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 1 0.999844409142079 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3092 3890 False False 0 0 0 0 0 0 0 Inf 1.3608069907404 Inf 0 0 0.000320776462830572 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Thr909Lys rpoC_p.Thr909Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Thr909Met rpoC_p.Thr909Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Thr927Ala rpoC_p.Thr927Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3747 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3137 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Thr927Ile rpoC_p.Thr927Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3402 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2830 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Thr958Asn rpoC_p.Thr958Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Thr958Ile rpoC_p.Thr958Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 12 0 12 2 15 16808 30517 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999508712170837 0.99918982468991 0.9997250046892 0.117647058823529 0.0145793168403025 0.36440916210125 0 0 0.264648469397051 0 0 0.218019360910534 0 0 0.653540789451653 0.0061384327665996 92 4649 False False 0.242083135015072 0.0268852067402331 1.04118589054373 0 0 0.000219447565534303 0.999508712170837 0.99918982468991 0.9997250046892 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 2 8 11500 23699 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999662546927068 0.999335191784523 0.999854300817065 0.2 0.0252107263268333 0.556095462307641 0 0 0.4592581264399 0 0 0.369416647552819 0 0 1.75054293172818 0.186838029212574 206 3890 False False 0 0 0 0 0 0 0 0.515195652173913 0.0532924302528778 2.58225829949872 0 0 0.000320720684566658 0.999662546927068 0.999335191784523 0.999854300817065 2 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Thr958Ser rpoC_p.Thr958Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3657 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Thr967Lys rpoC_p.Thr967Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3658 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3057 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Trp105Cys rpoC_p.Trp105Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3802 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Trp223Arg rpoC_p.Trp223Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Trp484Cys rpoC_p.Trp484Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3584 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Trp484Gly rpoC_p.Trp484Gly 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 87 0 16723 30532 0.00517549077929803 0.00414737112645291 0.00638008810625975 1 0.999879187193184 1 1 0.958485434007362 1 NA NA NA NA NA NA NA NA NA NA 3757 4649 False False Inf 42.1458818423443 Inf 0 0 0.000220562855006008 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 79 0 11423 23707 0.00686837071813597 0.00544141519236754 0.00855279089705807 1 0.999844409142079 1 1 0.954378747241388 1 NA NA NA NA NA NA NA NA NA NA 3146 3890 False False 0 0 0 0 0 0 0 Inf 43.4037608282271 Inf 0 0 0.00032288224505128 1 0.999844409142079 1 16 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Trp484Leu rpoC_p.Trp484Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 10 0 16800 30532 0.000594883997620464 0.000285305684944214 0.00109373983334496 1 0.999879187193184 1 1 0.691502892181239 1 NA NA NA NA NA NA NA NA NA NA 3508 4649 False False Inf 4.07313735951873 Inf 0 0 0.000219552052902727 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 9 0 11493 23707 0.000782472613458529 0.000357856744032263 0.00148485474620048 1 0.999844409142079 1 1 0.663732883120057 1 NA NA NA NA NA NA NA NA NA NA 2927 3890 False False 0 0 0 0 0 0 0 Inf 4.07050547199104 Inf 0 0 0.000320915993408392 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Trp484Ser rpoC_p.Trp484Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 40 0 16770 30532 0.00237953599048185 0.00170050288654007 0.00323885778355367 1 0.999879187193184 1 1 0.911902697121197 1 NA NA NA NA NA NA NA NA NA NA 3390 4649 False False Inf 18.8399988372443 Inf 0 0 0.000219944768298919 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 21 0 11481 23707 0.00182576943140323 0.00113052422891288 0.00278953561568501 1 0.999844409142079 1 1 0.83890238478092 1 NA NA NA NA NA NA NA NA NA NA 2820 3890 False False 0 0 0 0 0 0 0 Inf 10.7499748703754 Inf 0 0 0.000321251362564953 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Tyr1267Asn rpoC_p.Tyr1267Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Tyr586Ser rpoC_p.Tyr586Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3616 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3021 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Tyr612Ser rpoC_p.Tyr612Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Tyr61Cys rpoC_p.Tyr61Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2928 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Tyr704Cys rpoC_p.Tyr704Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Tyr704Phe rpoC_p.Tyr704Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3862 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3242 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Tyr722Cys rpoC_p.Tyr722Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 70.7603724184383 1 1627.5 4649 False False 0.908144446427509 0.0153974005043644 17.4461131425891 0 0 0.000219434511605659 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3213 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Tyr722His rpoC_p.Tyr722His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3437 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2861 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Tyr749His rpoC_p.Tyr749His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3468 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2887 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Tyr749Ser rpoC_p.Tyr749Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3376 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2808 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Tyr849Ser rpoC_p.Tyr849Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 9 0 16801 30532 0.000535395597858417 0.000244845253515427 0.00101610321951737 1 0.999879187193184 1 1 0.663732883120057 1 NA NA NA NA NA NA NA NA NA NA 3803 4649 False False Inf 3.58631764003717 Inf 0 0 0.000219538986540545 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 5 0 11497 23707 0.00043470700747696 0.000141162766530747 0.00101416710312943 1 0.999844409142079 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 3187 3890 False False 0 0 0 0 0 0 0 Inf 1.88913119689894 Inf 0 0 0.000320804359238686 1 0.999844409142079 1 2 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Tyr921Asp rpoC_p.Tyr921Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3403 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Tyr979Cys rpoC_p.Tyr979Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3417 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Val1020Ile rpoC_p.Val1020Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3718 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3114 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Val1031Met rpoC_p.Val1031Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3748 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3138 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Val1039Ala rpoC_p.Val1039Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 65 0 16745 30532 0.00386674598453301 0.00298550248723015 0.00492586728145316 1 0.999879187193184 1 1 0.944828365681186 1 NA NA NA NA NA NA NA NA NA NA 3719 4649 False False Inf 31.1911856882343 Inf 0 0 0.000220273105925916 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 43 0 11459 23707 0.00373848026430186 0.00270683805490488 0.00503244064340606 1 0.999844409142079 1 1 0.917788878845861 1 NA NA NA NA NA NA NA NA NA NA 3115 3890 False False 0 0 0 0 0 0 0 Inf 23.0892274203818 Inf 0 0 0.000321868030027081 1 0.999844409142079 1 24 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Val1039Gly rpoC_p.Val1039Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 29 0 16781 30532 0.00172516359309934 0.00115566411224569 0.00247669038907857 1 0.999879187193184 1 1 0.880555130930497 1 NA NA NA NA NA NA NA NA NA NA 3617 4649 False False Inf 13.4077314477923 Inf 0 0 0.000219800609634964 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 11 0 11491 23707 0.000956355416449313 0.000477502787107626 0.00171053820723243 1 0.999844409142079 1 1 0.715085847081845 1 NA NA NA NA NA NA NA NA NA NA 3022 3890 False False 0 0 0 0 0 0 0 Inf 5.1761760609822 Inf 0 0 0.000320971839633333 1 0.999844409142079 1 2 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Val1039Ile rpoC_p.Val1039Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3547 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2962 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Val1039Leu rpoC_p.Val1039Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3567 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2980 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Val1049Phe rpoC_p.Val1049Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3772 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3160 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Val1067Ala rpoC_p.Val1067Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Val1124Glu rpoC_p.Val1124Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 5 0 16805 30532 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 1 0.999879187193184 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 3509 4649 False False Inf 1.66460481015123 Inf 0 0 0.000219486736640675 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Val1124Gly rpoC_p.Val1124Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 17 0 16793 30532 0.00101130279595478 0.000589228022589122 0.0016187015795436 1 0.999879187193184 1 1 0.804935677030906 1 NA NA NA NA NA NA NA NA NA NA 3498 4649 False False Inf 7.50125453808733 Inf 0 0 0.000219643561005912 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 15 0 11487 23707 0.00130412102243088 0.000730084557867185 0.00215003854003137 1 0.999844409142079 1 1 0.781980639089466 1 NA NA NA NA NA NA NA NA NA NA 2917 3890 False False 0 0 0 0 0 0 0 Inf 7.40065484717093 Inf 0 0 0.000321083590414119 1 0.999844409142079 1 2 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Val1135Ala rpoC_p.Val1135Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 10 16810 30522 0 0 0.000219421459229958 0.999672474780558 0.999397752220648 0.999842928110511 0 0 0.30849710781876 0 0 0.602364635616474 0 0 0.30849710781876 0 0 2.7508832918645 0.304351925746536 296 4649 False False 0 0 0.81016282812198 0 0 0.000219421459229958 0.999672474780558 0.999397752220648 0.999842928110511 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 6 11502 23701 0 0 0.000320664925697395 0.9997469101953 0.999449212060655 0.99990711502044 0 0 0.4592581264399 0 0 0.707598226178713 0 0 0.4592581264399 0 0 4.98761680763255 0.55566908871896 373.5 3890 False False 0 0 0 0 0 0 0 0 0 1.75038628279554 0 0 0.000320664925697395 0.9997469101953 0.999449212060655 0.99990711502044 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Val1138Gly rpoC_p.Val1138Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 3 1 16807 30531 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999967247478055 0.999817528289014 0.999999170778282 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 3720 4649 False False 5.44969358005592 0.437509494081317 285.652299683162 0 0 0.000219460621016169 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3116 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Val1141Ala rpoC_p.Val1141Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3438 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2862 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Val1141Ile rpoC_p.Val1141Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3439 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2863 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Val1147Ala rpoC_p.Val1147Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 18 0 16792 30532 0.00107079119571683 0.000634738299600123 0.00169178580899694 1 0.999879187193184 1 1 0.814698031862147 1 NA NA NA NA NA NA NA NA NA NA 3599 4649 False False Inf 7.99147236998928 Inf 0 0 0.000219656639819404 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 12 0 11490 23707 0.0010432968179447 0.000539199208333142 0.00182171963730016 1 0.999844409142079 1 1 0.735351530602948 1 NA NA NA NA NA NA NA NA NA NA 3007 3890 False False 0 0 0 0 0 0 0 Inf 5.7314630344545 Inf 0 0 0.000320999770035263 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Val1194Leu rpoC_p.Val1194Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Val1252Leu rpoC_p.Val1252Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 147 0 16663 30532 0.00874479476502082 0.00739311776297434 0.0102703083234345 1 0.999879187193184 1 1 0.975217829510419 1 1 0.025 1 1 0.025 1 Inf 0.0469796356681983 Inf 0.353080769556742 371 4649 False False Inf 72.1251538952279 Inf 6.00096015362457e-05 1.51931041475518e-06 0.000334306239903293 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 82 0 11420 23707 0.00712919492262215 0.00567395945042685 0.00884159150242547 1 0.999844409142079 1 1 0.956010545813157 1 NA NA NA NA NA NA NA NA NA NA 3093 3890 False False 0 0 0 0 0 0 0 Inf 45.1207808772903 Inf 0 0 0.000322967051557219 1 0.999844409142079 1 67 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Val1252Met rpoC_p.Val1252Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 33 0 16777 30532 0.00196311719214753 0.00135169297871974 0.00275585192368924 1 0.999879187193184 1 1 0.89423718992542 1 NA NA NA NA NA NA NA NA NA NA 3469 4649 False False Inf 15.3840150429545 Inf 0 0 0.00021985300909755 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 21 0 11481 23707 0.00182576943140323 0.00113052422891288 0.00278953561568501 1 0.999844409142079 1 1 0.83890238478092 1 NA NA NA NA NA NA NA NA NA NA 2888 3890 False False 0 0 0 0 0 0 0 Inf 10.7499748703754 Inf 0 0 0.000321251362564953 1 0.999844409142079 1 7 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Val1272Ala rpoC_p.Val1272Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Val139Gly rpoC_p.Val139Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Val139Ile rpoC_p.Val139Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3721 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Val197Ile rpoC_p.Val197Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0465715996825058 Inf 0.355075831185839 416 4649 False False Inf 0.0465715996825058 Inf 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0528490600080728 Inf 0.32667783805277 340.5 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Val236Ile rpoC_p.Val236Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Val280Thr rpoC_p.Val280Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3510 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2929 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Val313Ala rpoC_p.Val313Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Val317Ala rpoC_p.Val317Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3452 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2874 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Val319Met rpoC_p.Val319Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3881 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3258 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Val422Ala rpoC_p.Val422Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Val431Ala rpoC_p.Val431Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3618 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3023 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Val431Leu rpoC_p.Val431Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 5 0 16805 30532 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 1 0.999879187193184 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 3822 4649 False False Inf 1.66460481015123 Inf 0 0 0.000219486736640675 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 5 0 11497 23707 0.00043470700747696 0.000141162766530747 0.00101416710312943 1 0.999844409142079 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 3206 3890 False False 0 0 0 0 0 0 0 Inf 1.88913119689894 Inf 0 0 0.000320804359238686 1 0.999844409142079 1 2 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Val431Met rpoC_p.Val431Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 53 0 16757 30532 0.00315288518738845 0.00236259227908935 0.00412204801610814 1 0.999879187193184 1 1 0.932765453693698 1 NA NA NA NA NA NA NA NA NA NA 3532 4649 False False Inf 25.2822435492522 Inf 0 0 0.000220115381611495 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 36 0 11466 23707 0.00312989045383411 0.00219307036741769 0.00433048000210719 1 0.999844409142079 1 1 0.902606244085508 1 NA NA NA NA NA NA NA NA NA NA 2949 3890 False False 0 0 0 0 0 0 0 Inf 19.154006257125 Inf 0 0 0.000321671561005972 1 0.999844409142079 1 11 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Val483Ala rpoC_p.Val483Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 3 0 540 0 16270 30532 0.032123735871505 0.0295096485687589 0.0349012958192496 1 0.999879187193184 1 1 0.993192021755532 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.775355179718088 Inf 0.0420217266412027 137 4649 False False Inf 275.617422311156 Inf 0.000184354452160019 3.80199337993978e-05 0.000538666477989668 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 262 0 11240 23707 0.0227786471917927 0.0201298863460097 0.0256725834172947 1 0.999844409142079 1 1 0.986018962743599 1 NA NA NA NA NA NA NA NA NA NA 3188 3890 False False 0 0 0 0 0 0 0 Inf 148.921087900994 Inf 0 0 0.000328138273108691 1 0.999844409142079 1 113 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Val483Gly rpoC_p.Val483Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 9 8 1 1265 2 15545 30530 0.0752528256989887 0.0713089865733139 0.0793443580294095 0.999934494956111 0.999763393503742 0.99999206693684 0.998421468034727 0.994309544676232 0.999808775254639 0.888888888888888 0.517503485082663 0.9971908632534 0.8 0.443904537692358 0.974789273673166 15.7118044387262 2.10612427503517 694.82582609005 0.00105925885440709 69 4649 False False 1242.21453843679 340.72659320902 8191.99999998509 0.000514370217964379 0.000222093872918676 0.00101326145182758 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 7 1 1031 2 10471 23705 0.0896365849417492 0.0844769591360422 0.0950049800783627 0.999915636731767 0.999695284447545 0.999989783053538 0.998063891577928 0.99302377513122 0.99976544222558 0.875 0.473490329124793 0.996840276468748 0.777777777777777 0.399906426283687 0.971855026522101 15.8471015184796 2.03532545484038 711.688479337606 0.00148641201373759 53 3890 False False 0 0 0 0 0 0 0 1167.02583325374 325.072932033244 8191.99999998509 0.000668066424890246 0.000268638193911611 0.00137598465721386 0.999915636731767 0.999695284447545 0.999989783053538 210 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Val486Ala rpoC_p.Val486Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3453 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Val490Ile rpoC_p.Val490Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3659 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3058 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Val517Ala rpoC_p.Val517Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3533 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2950 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Val517Leu rpoC_p.Val517Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 133 0 16677 30532 0.00791195716835217 0.006628593640724 0.0093696871925254 1 0.999879187193184 1 1 0.972645173715956 1 1 0.025 1 1 0.025 1 Inf 0.0469401992580364 Inf 0.353272611734801 373 4649 False False Inf 65.0585499438714 Inf 5.99592277251469e-05 1.51803506221518e-06 0.00033402565194853 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 95 0 11407 23707 0.00825943314206225 0.00668736649232634 0.0100874404479358 1 0.999844409142079 1 1 0.961913922429989 1 NA NA NA NA NA NA NA NA NA NA 2875 3890 False False 0 0 0 0 0 0 0 Inf 52.4658847142006 Inf 0 0 0.000323335061798685 1 0.999844409142079 1 18 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Val582Leu rpoC_p.Val582Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 5 0 16805 30532 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 1 0.999879187193184 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 3391 4649 False False Inf 1.66460481015123 Inf 0 0 0.000219486736640675 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 11498 23707 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 1 0.999844409142079 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2821 3890 False False 0 0 0 0 0 0 0 Inf 1.3608069907404 Inf 0 0 0.000320776462830572 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Val582Met rpoC_p.Val582Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3722 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3117 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Val592Ala rpoC_p.Val592Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3483 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2902 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Val592Phe rpoC_p.Val592Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3568 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2981 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Val611Phe rpoC_p.Val611Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3484 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2903 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Val626Ile rpoC_p.Val626Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Val629Met rpoC_p.Val629Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3392 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2822 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Val644Ala rpoC_p.Val644Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3863 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3243 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Val671Leu rpoC_p.Val671Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Val684Ile rpoC_p.Val684Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3548 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2963 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Val68Ala rpoC_p.Val68Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 80.2910622977969 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Val692Ala rpoC_p.Val692Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.75142405620251 0.304356294847217 327.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12235036001139 0.310791984491028 261 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Val692Glu rpoC_p.Val692Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3440 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2864 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Val709Phe rpoC_p.Val709Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Val756Ile rpoC_p.Val756Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Val775Ala rpoC_p.Val775Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 7 0 16803 30532 0.000416418798334324 0.000167437820935922 0.000857792460925722 1 0.999879187193184 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 3549 4649 False False Inf 2.61832748907777 Inf 0 0 0.000219512858481393 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 7 0 11495 23707 0.000608589810467744 0.000244718560881119 0.00125352303681455 1 0.999844409142079 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 2964 3890 False False 0 0 0 0 0 0 0 Inf 2.97179240572548 Inf 0 0 0.000320860166613556 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Val775Gly rpoC_p.Val775Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3393 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2823 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Val775Met rpoC_p.Val775Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3454 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2876 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Val803Leu rpoC_p.Val803Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3600 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Val824Met rpoC_p.Val824Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3619 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Val836Ile rpoC_p.Val836Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3804 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3189 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Val886Ala rpoC_p.Val886Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3404 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2831 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 6 3) Uncertain significance New Uncertain no 0 +Rifampicin rpoC p.Val930Ile rpoC_p.Val930Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Val974Met rpoC_p.Val974Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3377 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2809 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin rpoC p.Val989Asp rpoC_p.Val989Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 5 0 16805 30532 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 1 0.999879187193184 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 3511 4649 False False Inf 1.66460481015123 Inf 0 0 0.000219486736640675 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2930 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.1014C>T Rv1129c_c.1014C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.1023G>A Rv1129c_c.1023G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.1026C>T Rv1129c_c.1026C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.1042C>A Rv1129c_c.1042C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.1050C>T Rv1129c_c.1050C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 9 16810 30523 0 0 0.000219421459229958 0.999705227302502 0.999440503684993 0.999865202576615 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.920078094923294 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 9 11502 23698 0 0 0.000320664925697395 0.999620365292951 0.999279457952852 0.99982639261309 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.04405446176545 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.1068C>T Rv1129c_c.1068C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.106C>T Rv1129c_c.106C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.108G>C Rv1129c_c.108G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.1095G>A Rv1129c_c.1095G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.75142405620251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.12235036001139 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.-10T>C Rv1129c_c.-10T>C 2 upstream_gene_variant 1254544 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.-10T>G Rv1129c_c.-10T>G 2 upstream_gene_variant 1254544 1 5 0 5 1 5 16809 30527 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999836237390279 0.999617874429585 0.999946824656822 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.98214103142536 0.168452649138924 269 4649 False False 0.363222083407698 0.00768325476784986 3.24674897733262 0 0 0.000219434511605659 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 1 5 11501 23702 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999789091829417 0.999507879904061 0.999931515258336 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.521823750104981 0 0 0.521823750104981 0 0 2.24932299250856 0.180435646558949 191.5 3890 False False 0 0 0 0 0 0 0 0.412172854534388 0.00871781959321125 3.68423590106777 0 0 0.000320692802708327 0.999789091829417 0.999507879904061 0.999931515258336 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.1119C>A Rv1129c_c.1119C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.1119C>G Rv1129c_c.1119C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.1125A>C Rv1129c_c.1125A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 31 16808 30501 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.99898467181973 0.998559129586524 0.999310032760287 0.0606060606060606 0.0074258377422598 0.202264312526355 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.117075586126422 0.0135978841578837 0.460219602543187 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 17 11500 23690 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999282912220019 0.998852120448669 0.999582216212894 0.105263157894736 0.0130121643717774 0.331376664456765 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.24235294117647 0.0271662646620275 1.02125663054826 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.1131G>A Rv1129c_c.1131G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.1140C>T Rv1129c_c.1140C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.1143G>A Rv1129c_c.1143G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.1164C>A Rv1129c_c.1164C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.1167G>A Rv1129c_c.1167G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.6329128986197 0.189104318453829 214.057761575796 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.1176C>T Rv1129c_c.1176C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.117C>T Rv1129c_c.117C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.1182G>A Rv1129c_c.1182G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.-11A>C Rv1129c_c.-11A>C 2 upstream_gene_variant 1254545 1 4 0 4 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.75142405620251 0.304356294847217 327.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.120G>A Rv1129c_c.120G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.1212G>T Rv1129c_c.1212G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.1215T>C Rv1129c_c.1215T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.1216C>T Rv1129c_c.1216C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.1221C>T Rv1129c_c.1221C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.1224G>A Rv1129c_c.1224G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.1227C>T Rv1129c_c.1227C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.1233C>T Rv1129c_c.1233C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.1239G>T Rv1129c_c.1239G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.1242C>T Rv1129c_c.1242C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.1248G>C Rv1129c_c.1248G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.1257C>T Rv1129c_c.1257C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.1263G>A Rv1129c_c.1263G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.1269C>A Rv1129c_c.1269C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.75142405620251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.1299C>G Rv1129c_c.1299C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.75142405620251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.1299C>T Rv1129c_c.1299C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.-12A>C Rv1129c_c.-12A>C 2 upstream_gene_variant 1254546 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3673 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.-12A>T Rv1129c_c.-12A>T 2 upstream_gene_variant 1254546 NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4293 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.1302G>A Rv1129c_c.1302G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.1302G>C Rv1129c_c.1302G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 16810 30526 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.54251408011679 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 6 11502 23701 0 0 0.000320664925697395 0.9997469101953 0.999449212060655 0.99990711502044 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.75038628279554 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.1317G>C Rv1129c_c.1317G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.1317G>T Rv1129c_c.1317G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 7 16810 30525 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.26007067420399 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.132A>G Rv1129c_c.132A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.135C>T Rv1129c_c.135C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.1362G>A Rv1129c_c.1362G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.1389C>T Rv1129c_c.1389C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.341150751115529 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.-13A>C Rv1129c_c.-13A>C 2 upstream_gene_variant 1254547 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.-13A>G Rv1129c_c.-13A>G 2 upstream_gene_variant 1254547 1 2 1 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.81634838479386 0.0231376410853604 142.42572627634 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0528490600080728 Inf 0.32667783805277 340.5 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.1404G>A Rv1129c_c.1404G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 2 16807 30530 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999934494956111 0.999763393503742 0.99999206693684 0.6 0.146632799634673 0.947255049473683 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.72475754150056 0.312074221533576 32.6324551811023 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 1 11499 23706 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.999957818365883 0.999765001636458 0.999998932054057 0.75 0.194120449683243 0.99369053679029 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 6.18471171406209 0.496496186771195 324.103527365594 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.1410C>T Rv1129c_c.1410C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.1434T>G Rv1129c_c.1434T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.-15G>A Rv1129c_c.-15G>A 2 upstream_gene_variant 1254549 1 29 0 29 14 46 16796 30486 0.000832837596668649 0.000455392489979272 0.00139696554892221 0.998493383990567 0.997990890889788 0.998896763100815 0.233333333333333 0.133837343888848 0.360382787105757 0 0 0.119444869069502 0 0 0.0770618270519006 0 0 0.246258096378142 4.75816005336471e-06 39 4649 True False 0.552414135870859 0.280375149964015 1.02304899452337 0 0 0.000219604333908644 0.998493383990567 0.997990890889788 0.998896763100815 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 21 0 21 10 37 11492 23670 0.000869414014953921 0.000416994043678715 0.001598300185227 0.998439279537689 0.99784938772612 0.998900878063228 0.212765957446808 0.107032477154785 0.356636987762992 0 0 0.161097615219079 0 0 0.0948905874149899 0 0 0.395611260818747 0.000301153827611911 42 3890 True False 0 0 0 0 0 0 0 0.556673972963565 0.246793591373571 1.14230101810908 0 0 0.000320943914091465 0.998439279537689 0.99784938772612 0.998900878063228 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.-16T>A Rv1129c_c.-16T>A 2 upstream_gene_variant 1254550 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.-16T>G Rv1129c_c.-16T>G 2 upstream_gene_variant 1254550 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4376 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3660 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.177G>T Rv1129c_c.177G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.-17T>G Rv1129c_c.-17T>G 2 upstream_gene_variant 1254551 1 6 0 6 1 9 16809 30523 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999705227302502 0.999440503684993 0.999865202576615 0.1 0.00252857854446178 0.445016117028195 0 0 0.4592581264399 0 0 0.336267116879942 0 0 1.54245426255179 0.0957752854603084 186 4649 False False 0.201763605475902 0.00460699063398853 1.45637661246692 0 0 0.000219434511605659 0.999705227302502 0.999440503684993 0.999865202576615 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12235036001139 0.310791984491028 261 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.183G>T Rv1129c_c.183G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.184C>T Rv1129c_c.184C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.186G>A Rv1129c_c.186G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.18C>T Rv1129c_c.18C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.195T>G Rv1129c_c.195T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.-19T>C Rv1129c_c.-19T>C 2 upstream_gene_variant 1254553 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.-1C>T Rv1129c_c.-1C>T 2 upstream_gene_variant 1254535 1 8 0 8 0 10 16810 30522 0 0 0.000219421459229958 0.999672474780558 0.999397752220648 0.999842928110511 0 0 0.30849710781876 0 0 0.369416647552819 0 0 0.30849710781876 0 0 1.06386185129169 0.0571718104508685 179.5 4649 False False 0 0 0.81016282812198 0 0 0.000219421459229958 0.999672474780558 0.999397752220648 0.999842928110511 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 9 11502 23698 0 0 0.000320664925697395 0.999620365292951 0.999279457952852 0.99982639261309 0 0 0.336267116879942 0 0 0.409616397225003 0 0 0.336267116879942 0 0 1.4297388150818 0.104253118616784 129.5 3890 False False 0 0 0 0 0 0 0 0 0 1.04405446176545 0 0 0.000320664925697395 0.999620365292951 0.999279457952852 0.99982639261309 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.204G>A Rv1129c_c.204G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.211C>T Rv1129c_c.211C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 2 16808 30530 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999934494956111 0.999763393503742 0.99999206693684 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.8163969538315 0.131636449523742 25.0652602654423 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.216G>A Rv1129c_c.216G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.21A>G Rv1129c_c.21A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 4 16809 30528 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999868989912223 0.999664596427238 0.999964303043777 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.454042477244333 0.00922341562850508 4.58878013974823 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 4 11501 23703 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999831273463534 0.999568049920357 0.99995402584539 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.515237805408225 0.0104655802548345 5.20753049950472 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.-21C>G Rv1129c_c.-21C>G 2 upstream_gene_variant 1254555 1 1 0 1 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 70.7538526941519 1 1627.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.-21C>T Rv1129c_c.-21C>T 2 upstream_gene_variant 1254555 1 2 0 2 2 3 16808 30529 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999901742434167 0.999712876815577 0.99997973646933 0.4 0.0527449505263169 0.853367200365326 0 0 0.841886116991581 0 0 0.707598226178713 0 0 9.67143092088814 0.54200780235351 733.5 4649 False False 1.21089163890211 0.101157890363798 10.5697741171107 0 0 0.000219447565534303 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 80.2876797383181 1 1214.5 3890 False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 0 0 0.000320692802708327 0.999915636731767 0.999695284447545 0.999989783053538 2 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.-22A>G Rv1129c_c.-22A>G 2 upstream_gene_variant 1254556 1 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4328 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3623 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.231C>T Rv1129c_c.231C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.-23C>A Rv1129c_c.-23C>A 2 upstream_gene_variant 1254557 1 1 0 1 5 35 16805 30497 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 0.998853661731953 0.99840607808452 0.999201407537638 0.125 0.0418596261386167 0.26803291736172 0 0 0.975 0 0 0.100032435572105 0 0 70.7007801466144 1 1627.5 4649 False False 0.259251073235006 0.0792496663466721 0.664702862145873 0 0 0.000219486736640675 0.998853661731953 0.99840607808452 0.999201407537638 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 5 26 11497 23681 0.00043470700747696 0.000141162766530747 0.00101416710312943 0.99890327751297 0.998393457445096 0.999283463292248 0.161290322580645 0.0545243262150835 0.337271584973179 0 0 0.975 0 0 0.132274604497754 0 0 80.2343684117829 1 1214.5 3890 False False 0 0 0 0 0 0 0 0.396106676658124 0.118756797981567 1.04861298322673 0 0 0.000320804359238686 0.99890327751297 0.998393457445096 0.999283463292248 2 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.-23C>G Rv1129c_c.-23C>G 2 upstream_gene_variant 1254557 NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4294 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3591 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.-23C>T Rv1129c_c.-23C>T 2 upstream_gene_variant 1254557 1 5 0 5 0 7 16810 30525 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 0 0 0.409616397225003 0 0 0.521823750104981 0 0 0.409616397225003 0 0 1.98189325920797 0.168444418238817 233.5 4649 False False 0 0 1.26007067420399 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 7 11502 23700 0 0 0.000320664925697395 0.999704728561184 0.999391723222185 0.999881277590374 0 0 0.409616397225003 0 0 0.521823750104981 0 0 0.409616397225003 0 0 2.24893704635384 0.180414610937576 164.5 3890 False False 0 0 0 0 0 0 0 0 0 1.42986888806462 0 0 0.000320664925697395 0.999704728561184 0.999391723222185 0.999881277590374 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.246A>G Rv1129c_c.246A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.249G>A Rv1129c_c.249G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.24G>T Rv1129c_c.24G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.-25G>A Rv1129c_c.-25G>A 2 upstream_gene_variant 1254559 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.264G>A Rv1129c_c.264G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.264G>C Rv1129c_c.264G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.9820231071276 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.12235036001139 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.-26C>T Rv1129c_c.-26C>T 2 upstream_gene_variant 1254560 1 4 0 4 9 5 16801 30527 0.000535395597858417 0.000244845253515427 0.00101610321951737 0.999836237390279 0.999617874429585 0.999946824656822 0.642857142857142 0.351380110615991 0.87240157014084 0 0 0.602364635616474 0 0 0.521823750104981 0 0 2.75280793337469 0.304367542110601 364 4649 False False 3.27055532408785 0.984078999068247 12.4208935149813 0 0 0.000219538986540545 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 6 5 11496 23702 0.000521648408972352 0.000191459062774625 0.00113506056981396 0.999789091829417 0.999507879904061 0.999931515258336 0.545454545454545 0.233793597659345 0.832511905936292 0 0 0.602364635616474 0 0 0.521823750104981 0 0 3.12384860707978 0.310829875055736 298 3890 False False 0 0 0 0 0 0 0 2.4741127348643 0.628946063075147 10.2530574950399 0 0 0.000320832260499258 0.999789091829417 0.999507879904061 0.999931515258336 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.-27C>T Rv1129c_c.-27C>T 2 upstream_gene_variant 1254561 1 1 0 1 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 70.7538526941519 1 1627.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.282C>T Rv1129c_c.282C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.-28delTinsCC Rv1129c_c.-28delTinsCC 2 upstream_gene_variant 1254562 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4382 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.-28T>C Rv1129c_c.-28T>C 2 upstream_gene_variant 1254562 NA 0 0 0 9445 14637 7365 15895 0.561867935752528 0.554327634343374 0.569386822546366 0.520601336302895 0.514979566540782 0.526219185282125 0.392201644381695 0.386027733971515 0.398401580411886 NA NA NA 0 0 0.000251992529176699 NA NA NA NA 4359 4649 False True 1.39263616959707 1.34070320343481 1.44667853768381 0 0 0.000500740772687167 0.520601336302895 0.514979566540782 0.526219185282125 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 6324 11233 5178 12474 0.549817423056859 0.540670184613051 0.558939434348059 0.526173703969291 0.519793729669335 0.532547259646992 0.360198211539556 0.353092422214324 0.367350335095836 NA NA NA 0 0 0.000328342723458032 NA NA NA NA 3646 3890 False True 0 1 1 0 0 0 0 1.35625013990498 1.29661677656444 1.41861206198424 0 0 0.000712160247488952 0.526173703969291 0.519793729669335 0.532547259646992 3366 5) Not assoc w R New NotAwR yes 5 +Rifampicin Rv1129c c.294G>A Rv1129c_c.294G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.-29A>G Rv1129c_c.-29A>G 2 upstream_gene_variant 1254563 NA 0 0 0 1 67 16809 30465 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.997805581029739 0.997213991233483 0.998298963139739 0.0147058823529411 0.00037225140289861 0.079233989912788 NA NA NA 0 0 0.0535696541270968 NA NA NA NA 4323 4649 False True 0.0270510733855264 0.000679456234666636 0.156004281146222 0 0 0.000219434511605659 0.997805581029739 0.997213991233483 0.998298963139739 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 65 11502 23642 0 0 0.000320664925697395 0.997258193782427 0.996506658918828 0.997883313865647 0 0 0.0551716343188133 NA NA NA 0 0 0.0551716343188133 NA NA NA NA 3617 3890 False True 1 1 1 0 0 0 0 0 0 0.120057666199976 0 0 0.000320664925697395 0.997258193782427 0.996506658918828 0.997883313865647 NA 5) Not assoc w R New NotAwR yes 5 +Rifampicin Rv1129c c.-2A>C Rv1129c_c.-2A>C 2 upstream_gene_variant 1254536 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.-2A>G Rv1129c_c.-2A>G 2 upstream_gene_variant 1254536 1 3 0 3 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 4.39540875925228 0.556930310247326 910.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 4.98803779447094 0.555669835711629 381 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.303C>T Rv1129c_c.303C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.306C>T Rv1129c_c.306C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.309C>T Rv1129c_c.309C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.-31T>C Rv1129c_c.-31T>C 2 upstream_gene_variant 1254565 1 5 0 5 1 7 16809 30525 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.99977073234639 0.999527678427408 0.999907817703152 0.125 0.0031597235312519 0.526509670875206 0 0 0.521823750104981 0 0 0.409616397225003 0 0 1.98201117577687 0.168448333959741 240 4649 False False 0.2594273475944 0.00575995110596449 2.01970184240593 0 0 0.000219434511605659 0.99977073234639 0.999527678427408 0.999907817703152 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 4 11501 23703 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999831273463534 0.999568049920357 0.99995402584539 0.2 0.00505076337946806 0.716417936118089 0 0 0.841886116991581 0 0 0.602364635616474 0 0 10.9718176678192 1 504 3890 False False 0 0 0 0 0 0 0 0.515237805408225 0.0104655802548345 5.20753049950472 0 0 0.000320692802708327 0.999831273463534 0.999568049920357 0.99995402584539 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.-31T>G Rv1129c_c.-31T>G 2 upstream_gene_variant 1254565 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.327C>T Rv1129c_c.327C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.-32C>T Rv1129c_c.-32C>T 2 upstream_gene_variant 1254566 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.334C>A Rv1129c_c.334C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.336G>C Rv1129c_c.336G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.345G>A Rv1129c_c.345G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.369G>A Rv1129c_c.369G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.-36T>C Rv1129c_c.-36T>C 2 upstream_gene_variant 1254570 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.-37G>A Rv1129c_c.-37G>A 2 upstream_gene_variant 1254571 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4301 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.-38T>A Rv1129c_c.-38T>A 2 upstream_gene_variant 1254572 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.-38T>C Rv1129c_c.-38T>C 2 upstream_gene_variant 1254572 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.390C>T Rv1129c_c.390C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.39T>C Rv1129c_c.39T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.750576632084797 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.-3A>G Rv1129c_c.-3A>G 2 upstream_gene_variant 1254537 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4286 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3586 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.3G>A Rv1129c_c.3G>A 2 initiator_codon_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 17 16809 30515 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999443207126948 0.999108669858669 0.999675615241488 0.0555555555555555 0.00140555616736942 0.272943599673368 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.106788030221904 0.00255919517247829 0.681652704725612 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 14 11501 23693 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999409457122369 0.999009367705732 0.999677108302285 0.0666666666666666 0.0016864302413527 0.319484566578303 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.147148695144521 0.00348375000880481 0.967404595956322 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.3G>T Rv1129c_c.3G>T 2 initiator_codon_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.-40T>G Rv1129c_c.-40T>G 2 upstream_gene_variant 1254574 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.411C>T Rv1129c_c.411C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.341150751115529 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.-41T>C Rv1129c_c.-41T>C 2 upstream_gene_variant 1254575 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.426C>T Rv1129c_c.426C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.9820231071276 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.24912710990902 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.-42C>A Rv1129c_c.-42C>A 2 upstream_gene_variant 1254576 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.-42C>T Rv1129c_c.-42C>T 2 upstream_gene_variant 1254576 1 7 0 7 2 9 16808 30523 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999705227302502 0.999440503684993 0.999865202576615 0.181818181818181 0.0228311982999596 0.517755852360172 0 0 0.409616397225003 0 0 0.336267116879942 0 0 1.26013806129303 0.0561520977460242 161.5 4649 False False 0.403551218996245 0.042426946391261 1.95003944120586 0 0 0.000219447565534303 0.999705227302502 0.999440503684993 0.999865202576615 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 1 7 11501 23700 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999704728561184 0.999391723222185 0.999881277590374 0.125 0.0031597235312519 0.526509670875206 0 0 0.4592581264399 0 0 0.409616397225003 0 0 1.75046460046947 0.186839191554249 209.5 3890 False False 0 0 0 0 0 0 0 0.294384339250003 0.00653526389697788 2.29204336611244 0 0 0.000320692802708327 0.999704728561184 0.999391723222185 0.999881277590374 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.-42delC Rv1129c_c.-42delC 2 upstream_gene_variant 1254575 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4336 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.435C>T Rv1129c_c.435C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.-43A>G Rv1129c_c.-43A>G 2 upstream_gene_variant 1254577 1 1 1 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0465743703410529 Inf 0.355062208233877 391.5 4649 False False Inf 0.341150751115529 Inf 5.94919388422868e-05 1.50620434989522e-06 0.000331422795737767 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.052853655209362 Inf 0.326658713928652 320 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 8.69489609599165e-05 2.20135467503192e-06 0.000484352330576856 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.-43A>T Rv1129c_c.-43A>T 2 upstream_gene_variant 1254577 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.-44T>C Rv1129c_c.-44T>C 2 upstream_gene_variant 1254578 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4307 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.456G>A Rv1129c_c.456G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.-45G>T Rv1129c_c.-45G>T 2 upstream_gene_variant 1254579 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.-46C>G Rv1129c_c.-46C>G 2 upstream_gene_variant 1254580 NA 0 0 0 27 61 16783 30471 0.00160618679357525 0.00105874575067693 0.00233606351154523 0.998002096161404 0.997434338630312 0.998471427796032 0.306818181818181 0.212876548039535 0.414197210831896 NA NA NA 0 0 0.0586812239322925 NA NA NA NA 4314 4649 False True 0.803620564525187 0.490799742380557 1.28428465298692 0 0 0.000219774419269166 0.998002096161404 0.997434338630312 0.998471427796032 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 14 49 11488 23658 0.00121717962093548 0.000665598145642159 0.00204137811638842 0.997933099928291 0.99726835820432 0.998470516759952 0.222222222222222 0.127150743253126 0.344644153704361 NA NA NA 0 0 0.0725192636642774 NA NA NA NA 3608 3890 False True 0 1 1 0 0 0 0 0.588390370075606 0.299892929242727 1.08355875615417 0 0 0.000321055645424387 0.997933099928291 0.99726835820432 0.998470516759952 5 5) Not assoc w R New NotAwR yes 5 +Rifampicin Rv1129c c.-46C>T Rv1129c_c.-46C>T 2 upstream_gene_variant 1254580 1 7 0 7 2 9 16808 30523 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999705227302502 0.999440503684993 0.999865202576615 0.181818181818181 0.0228311982999596 0.517755852360172 0 0 0.409616397225003 0 0 0.336267116879942 0 0 1.26013806129303 0.0561520977460242 161.5 4649 False False 0.403551218996245 0.042426946391261 1.95003944120586 0 0 0.000219447565534303 0.999705227302502 0.999440503684993 0.999865202576615 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 1 8 11501 23699 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999662546927068 0.999335191784523 0.999854300817065 0.111111111111111 0.00280913674659921 0.482496514917337 0 0 0.409616397225003 0 0 0.369416647552819 0 0 1.42993789808289 0.104256245416693 139.5 3890 False False 0 0 0 0 0 0 0 0.257575428223632 0.00580827991067691 1.92165917942206 0 0 0.000320692802708327 0.999662546927068 0.999335191784523 0.999854300817065 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.-47G>A Rv1129c_c.-47G>A 2 upstream_gene_variant 1254581 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.-47G>C Rv1129c_c.-47G>C 2 upstream_gene_variant 1254581 1 1 0 1 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 70.7515377372301 1 1627.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 80.2739436376013 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.480C>T Rv1129c_c.480C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 6 21 16804 30511 0.000356930398572278 0.000130998068917797 0.000776724091447791 0.999312197039172 0.998948811248646 0.999574190302931 0.222222222222222 0.0862169399475667 0.422583060044378 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.518771040908627 0.171301437591594 1.32920489195504 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 5 13 11497 23694 0.00043470700747696 0.000141162766530747 0.00101416710312943 0.999451638756485 0.999062468123692 0.999707989454911 0.277777777777777 0.0969492125255593 0.534801965583056 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.792648249376091 0.2211985711168 2.36995309353315 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.-48A>C Rv1129c_c.-48A>C 2 upstream_gene_variant 1254582 NA 0 0 0 78 332 16732 30200 0.00464009518143961 0.00366947919738968 0.00578771370891133 0.989126162714529 0.987898770872839 0.990259106226835 0.190243902439024 0.153385941982539 0.231641735220408 NA NA NA 0 0 0.0110495826020882 NA NA NA NA 4356 4649 False True 0.424048572967461 0.326795984691126 0.544575156010379 0 0 0.000220444229206293 0.989126162714529 0.987898770872839 0.990259106226835 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 64 310 11438 23397 0.00556424969570509 0.00428770926647413 0.00709994276632297 0.986923693423883 0.985395281854376 0.988330936670136 0.171122994652406 0.134351006262911 0.213196061104572 NA NA NA 0 0 0.0118290907684707 NA NA NA NA 3643 3890 False True 0 1 1 0 0 0 0 0.42230708052953 0.317181471023349 0.554856568830832 0 0 0.00032245887971469 0.986923693423883 0.985395281854376 0.988330936670136 27 5) Not assoc w R New NotAwR yes 5 +Rifampicin Rv1129c c.-48A>G Rv1129c_c.-48A>G 2 upstream_gene_variant 1254582 NA 0 0 0 45 299 16765 30233 0.00267697798929208 0.00195325583726912 0.00358038570852014 0.990206995938687 0.98903814418608 0.991281099938447 0.130813953488372 0.0970410492441649 0.171099270913188 NA NA NA 0 0 0.012261595907535 NA NA NA NA 4287 4649 False True 0.271405729606691 0.19369799976047 0.372496013311969 0 0 0.000220010357494106 0.990206995938687 0.98903814418608 0.991281099938447 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 35 266 11467 23441 0.00304294905233872 0.00212041293060913 0.00422948863748576 0.988779685325009 0.987356177332933 0.990081385035466 0.116279069767441 0.0823433701624889 0.157992320815133 NA NA NA 0 0 0.0137722505851113 NA NA NA NA 3587 3890 False True 0 1 1 0 0 0 0 0.268975504078063 0.183311490969084 0.383896248929132 0 0 0.000321643513580867 0.988779685325009 0.987356177332933 0.990081385035466 30 5) Not assoc w R New NotAwR yes 5 +Rifampicin Rv1129c c.-48dupA Rv1129c_c.-48dupA 2 upstream_gene_variant 1254581 1 11 0 11 5 15 16805 30517 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 0.999508712170837 0.99918982468991 0.9997250046892 0.25 0.0865714691014345 0.491045871707957 0 0 0.284914152918154 0 0 0.218019360910534 0 0 0.72364251477674 0.010313184817944 106 4649 False False 0.60531587821085 0.172105516510624 1.75237918161785 0 0 0.000219486736640675 0.999508712170837 0.99918982468991 0.9997250046892 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 5 8 11497 23699 0.00043470700747696 0.000141162766530747 0.00101416710312943 0.999662546927068 0.999335191784523 0.999854300817065 0.384615384615384 0.13857933889016 0.684222397085936 0 0 0.521823750104981 0 0 0.369416647552819 0 0 2.24982164553322 0.180462832117993 197 3890 False False 0 0 0 0 0 0 0 1.28832521527354 0.331534989700332 4.46795788919692 0 0 0.000320804359238686 0.999662546927068 0.999335191784523 0.999854300817065 2 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.48G>A Rv1129c_c.48G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.-49A>C Rv1129c_c.-49A>C 2 upstream_gene_variant 1254583 NA 0 0 0 57 265 16753 30267 0.00339083878643664 0.0025691692652669 0.00439102203662388 0.991320581684789 0.990215637226873 0.992330452291454 0.177018633540372 0.136916685773558 0.223179767577178 NA NA NA 0 0 0.0138238604601256 NA NA NA NA 4368 4649 False True 0.388602660858263 0.286429964223112 0.51943236400788 0 0 0.000220167931279891 0.991320581684789 0.990215637226873 0.992330452291454 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 44 241 11458 23466 0.00382542166579725 0.00278089167957464 0.00513208463094438 0.989834226177922 0.988474360465858 0.99107189832924 0.15438596491228 0.114472644400361 0.201660584188742 NA NA NA 0 0 0.0151900038743625 NA NA NA NA 3654 3890 False True 0 1 1 0 0 0 0 0.373908968638122 0.264517497816651 0.51779459800114 0 0 0.000321896116623384 0.989834226177922 0.988474360465858 0.99107189832924 14 5) Not assoc w R New NotAwR yes 5 +Rifampicin Rv1129c c.-49A>G Rv1129c_c.-49A>G 2 upstream_gene_variant 1254583 1 2 0 2 1 6 16809 30526 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999803484868334 0.999572318737888 0.999927879105266 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.841886116991581 0 0 0.4592581264399 0 0 9.66990770238623 0.54198685894464 452.5 4649 False False 0.302675154183274 0.00658396461982027 2.49513982006856 0 0 0.000219434511605659 0.999803484868334 0.999572318737888 0.999927879105266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 6 11502 23701 0 0 0.000320664925697395 0.9997469101953 0.999449212060655 0.99990711502044 0 0 0.4592581264399 0 0 0.841886116991581 0 0 0.4592581264399 0 0 10.9699414580625 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 1.75038628279554 0 0 0.000320664925697395 0.9997469101953 0.999449212060655 0.99990711502044 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.-4G>A Rv1129c_c.-4G>A 2 upstream_gene_variant 1254538 1 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4315 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3609 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.-4G>T Rv1129c_c.-4G>T 2 upstream_gene_variant 1254538 1 2 0 2 2 3 16808 30529 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999901742434167 0.999712876815577 0.99997973646933 0.4 0.0527449505263169 0.853367200365326 0 0 0.841886116991581 0 0 0.707598226178713 0 0 9.67143092088814 0.54200780235351 733.5 4649 False False 1.21089163890211 0.101157890363798 10.5697741171107 0 0 0.000219447565534303 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 2 3 11500 23704 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.99987345509765 0.999630227076139 0.999973902638554 0.4 0.0527449505263169 0.853367200365326 0 0 0.841886116991581 0 0 0.707598226178713 0 0 10.9732321332222 1 1214.5 3890 False False 0 0 0 0 0 0 0 1.37414492753623 0.114734681491877 11.9942804069209 0 0 0.000320720684566658 0.99987345509765 0.999630227076139 0.999973902638554 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.510C>T Rv1129c_c.510C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.519C>T Rv1129c_c.519C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.540T>C Rv1129c_c.540T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.552G>A Rv1129c_c.552G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.567A>G Rv1129c_c.567A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.570G>A Rv1129c_c.570G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.576C>A Rv1129c_c.576C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.57T>C Rv1129c_c.57T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.591G>C Rv1129c_c.591G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 13 16810 30519 0 0 0.000219421459229958 0.999574217214725 0.999272008529012 0.999773269742809 0 0 0.24705263800047 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.595805680834415 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 13 11502 23694 0 0 0.000320664925697395 0.999451638756485 0.999062468123692 0.999707989454911 0 0 0.24705263800047 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.676068752178923 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.597G>A Rv1129c_c.597G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.615G>A Rv1129c_c.615G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.627T>C Rv1129c_c.627T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.636G>A Rv1129c_c.636G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.642C>T Rv1129c_c.642C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.908144446427509 0.0153974005043644 17.4461131425891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.648C>G Rv1129c_c.648C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.6329128986197 0.189104318453829 214.057761575796 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.651G>A Rv1129c_c.651G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.654C>T Rv1129c_c.654C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.660C>T Rv1129c_c.660C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.663C>T Rv1129c_c.663C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.678C>T Rv1129c_c.678C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.908144446427509 0.0153974005043644 17.4461131425891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.682C>A Rv1129c_c.682C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.-6G>A Rv1129c_c.-6G>A 2 upstream_gene_variant 1254540 1 17 1 16 3 20 16807 30512 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999344949561116 0.998988508123428 0.999599833714555 0.130434782608695 0.0277515074227932 0.335889137537121 0.0588235294117647 0.00148817439126663 0.28688939666722 0.0476190476190476 0.00120488344836351 0.238159909936821 0.11346462783364 0.00270965157773597 0.730481458906448 0.00943547024451064 100 4649 False False 0.272315106800737 0.051817643913604 0.918414222747135 5.94954783436458e-05 1.50629396217601e-06 0.000331442511213996 0.999344949561116 0.998988508123428 0.999599833714555 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 15 1 14 2 18 11500 23689 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999240730585902 0.998800291409329 0.999549948712402 0.1 0.0123485271702948 0.316982714019082 0.0666666666666666 0.0016864302413527 0.319484566578303 0.0526315789473684 0.00133162880417942 0.260280654195214 0.147136645962732 0.00348346510218058 0.967325375315896 0.029156169366244 92 3890 False False 0 0 0 0 0 0 0 0.22887922705314 0.0257461900638141 0.956251644487591 8.69489609599165e-05 2.20135467503192e-06 0.000484352330576856 0.999240730585902 0.998800291409329 0.999549948712402 3 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.70C>A Rv1129c_c.70C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 8 16810 30524 0 0 0.000219421459229958 0.999737979824446 0.999483781433772 0.999886871715824 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.06393155676265 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 6 11502 23701 0 0 0.000320664925697395 0.9997469101953 0.999449212060655 0.99990711502044 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.75038628279554 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.736C>T Rv1129c_c.736C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 8 16809 30524 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999737979824446 0.999483781433772 0.999886871715824 0.111111111111111 0.00280913674659921 0.482496514917337 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.226991492652745 0.00511932236302294 1.69341645046941 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 6 11501 23701 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.9997469101953 0.999449212060655 0.99990711502044 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.343462887285163 0.00747035147172492 2.83150389371471 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.741G>C Rv1129c_c.741G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.742C>T Rv1129c_c.742C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.753G>A Rv1129c_c.753G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.756A>C Rv1129c_c.756A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.777G>A Rv1129c_c.777G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.7C>A Rv1129c_c.7C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.750576632084797 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.807C>T Rv1129c_c.807C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.816C>T Rv1129c_c.816C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.828A>C Rv1129c_c.828A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.831G>C Rv1129c_c.831G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.852C>T Rv1129c_c.852C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.858G>A Rv1129c_c.858G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.861C>T Rv1129c_c.861C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.864C>A Rv1129c_c.864C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 6 16807 30526 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999803484868334 0.999572318737888 0.999927879105266 0.333333333333333 0.0748546314196918 0.700704943791459 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.908133515796989 0.146921475063029 4.25286483046122 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 6 11500 23701 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.9997469101953 0.999449212060655 0.99990711502044 0.25 0.0318540262499442 0.650855794412824 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.686985507246376 0.0677936853587072 3.84271972888173 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.888A>C Rv1129c_c.888A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.894G>A Rv1129c_c.894G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.-8T>C Rv1129c_c.-8T>C 2 upstream_gene_variant 1254542 NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4343 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3635 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.-8T>G Rv1129c_c.-8T>G 2 upstream_gene_variant 1254542 1 4 0 4 5 6 16805 30526 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 0.999803484868334 0.999572318737888 0.999927879105266 0.454545454545454 0.167488094063707 0.766206402340654 0 0 0.602364635616474 0 0 0.4592581264399 0 0 2.75206247101429 0.304361468519899 362 4649 False False 1.51373599127243 0.36538656529008 5.95429757230108 0 0 0.000219486736640675 0.999803484868334 0.999572318737888 0.999927879105266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 4 5 11498 23702 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 0.999789091829417 0.999507879904061 0.999931515258336 0.444444444444444 0.136995662265166 0.787991493221131 0 0 0.602364635616474 0 0 0.521823750104981 0 0 3.12330508799509 0.31081611974933 296 3890 False False 0 0 0 0 0 0 0 1.64912158636284 0.327175514256965 7.66332787722062 0 0 0.000320776462830572 0.999789091829417 0.999507879904061 0.999931515258336 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.903T>C Rv1129c_c.903T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.75142405620251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.12235036001139 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.90G>A Rv1129c_c.90G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.915G>T Rv1129c_c.915G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.9820231071276 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.918G>A Rv1129c_c.918G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.927G>A Rv1129c_c.927G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.927G>C Rv1129c_c.927G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.936G>A Rv1129c_c.936G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 8 16810 30524 0 0 0.000219421459229958 0.999737979824446 0.999483781433772 0.999886871715824 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.06393155676265 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 7 11502 23700 0 0 0.000320664925697395 0.999704728561184 0.999391723222185 0.999881277590374 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.42986888806462 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.939C>A Rv1129c_c.939C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.948C>G Rv1129c_c.948C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.957C>T Rv1129c_c.957C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.960G>A Rv1129c_c.960G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.969A>G Rv1129c_c.969A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 13 85 16797 30447 0.000773349196906603 0.000411838091387593 0.00132208760075144 0.997216035634744 0.996558718794529 0.997775681133764 0.132653061224489 0.0725643124781498 0.216154002871413 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.277228076442221 0.141787222683437 0.500041048266417 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 8 50 11494 23657 0.000695531211963136 0.000300327312744212 0.00137001129783907 0.997890918294174 0.997220372511225 0.998434206102271 0.137931034482758 0.0614796629657354 0.253809755276478 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 0 0.329312684879067 0.134787980331285 0.700413304518791 NA NA NA NA NA NA 20 5) Not assoc w R Now listed Silent mutation no 0 +Rifampicin Rv1129c c.975G>A Rv1129c_c.975G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.978C>T Rv1129c_c.978C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.982C>A Rv1129c_c.982C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.987G>A Rv1129c_c.987G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.993G>A Rv1129c_c.993G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.993G>T Rv1129c_c.993G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.996A>C Rv1129c_c.996A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.9G>A Rv1129c_c.9G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.9G>T Rv1129c_c.9G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 17 16810 30515 0 0 0.000219421459229958 0.999443207126948 0.999108669858669 0.999675615241488 0 0 0.195064322969093 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.439992498211177 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 13 11502 23694 0 0 0.000320664925697395 0.999451638756485 0.999062468123692 0.999707989454911 0 0 0.24705263800047 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.676068752178923 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv1129c c.-9T>A Rv1129c_c.-9T>A 2 upstream_gene_variant 1254543 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c c.-9T>G Rv1129c_c.-9T>G 2 upstream_gene_variant 1254543 NA 0 0 0 33 815 16777 29717 0.00196311719214753 0.00135169297871974 0.00275585192368924 0.973306694615485 0.971436666306715 0.97508591896239 0.0389150943396226 0.0269360604395454 0.0542194946386943 NA NA NA 0 0 0.00451600450608184 NA NA NA NA 4279 4649 False True 0.0717211081048367 0.0490098854903937 0.101615071014547 0 0 0.00021985300909755 0.973306694615485 0.971436666306715 0.97508591896239 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 28 601 11474 23106 0.00243435924187097 0.00161820482579939 0.00351641960825614 0.97464883789598 0.972567667752738 0.976612507052123 0.0445151033386327 0.029780579382705 0.0636964994695279 NA NA NA 0 0 0.00611910414247245 NA NA NA NA 3579 3890 False True 1 1 1 0 0 0 0 0.0938195796500922 0.0617779177362152 0.137106441694511 0 0 0.000321447318471383 0.97464883789598 0.972567667752738 0.976612507052123 4 5) Not assoc w R New NotAwR yes 5 +Rifampicin Rv1129c LoF Rv1129c_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 5 0 5 10 9 16800 30523 0.000594883997620464 0.000285305684944214 0.00109373983334496 0.999705227302502 0.999440503684993 0.999865202576615 0.526315789473684 0.288643247916998 0.755525310533804 0 0 0.521823750104981 0 0 0.336267116879942 0 0 1.98294313152881 0.168479331034759 281 4649 False False 2.01871693121693 0.737037657581534 5.6160459688276 0 0 0.000219552052902727 0.999705227302502 0.999440503684993 0.999865202576615 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 5 5 11497 23702 0.00043470700747696 0.000141162766530747 0.00101416710312943 0.999789091829417 0.999507879904061 0.999931515258336 0.5 0.187086028447398 0.812913971552601 0 0 0.707598226178713 0 0 0.521823750104981 0 0 4.98999733770619 0.555673330963813 479.5 3890 False False 0 0 0 0 0 0 0 2.06158128207358 0.474355337248179 8.96017305588707 0 0 0.000320804359238686 0.999789091829417 0.999507879904061 0.999931515258336 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ala100Thr Rv1129c_p.Ala100Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 0 8 16810 30524 0 0 0.000219421459229958 0.999737979824446 0.999483781433772 0.999886871715824 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 1.06393155676265 0.057171463062894 176 4649 False False 0 0 1.06393155676265 0 0 0.000219421459229958 0.999737979824446 0.999483781433772 0.999886871715824 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 0 8 11502 23699 0 0 0.000320664925697395 0.999662546927068 0.999335191784523 0.999854300817065 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 1.20731769892417 0.0599154010311281 117.5 3890 False False 0 0 0 0 0 0 0 0 0 1.20731769892417 0 0 0.000320664925697395 0.999662546927068 0.999335191784523 0.999854300817065 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ala104Thr Rv1129c_p.Ala104Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4373 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ala10Val Rv1129c_p.Ala10Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4429 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3704 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ala111Gly Rv1129c_p.Ala111Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4399 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ala111Thr Rv1129c_p.Ala111Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ala129Pro Rv1129c_p.Ala129Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4295 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3592 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ala130Pro Rv1129c_p.Ala130Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 1 16807 30531 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999967247478055 0.999817528289014 0.999999170778282 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 70.771098821806 1 1627.5 4649 False False 5.44969358005592 0.437509494081317 285.652299683162 0 0 0.000219460621016169 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3664 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ala130Val Rv1129c_p.Ala130Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4406 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3685 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ala141Thr Rv1129c_p.Ala141Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4302 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ala150Thr Rv1129c_p.Ala150Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4414 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3693 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ala150Val Rv1129c_p.Ala150Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ala195Pro Rv1129c_p.Ala195Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 7 0 16803 30532 0.000416418798334324 0.000167437820935922 0.000857792460925722 1 0.999879187193184 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 4357 4649 False False Inf 2.61832748907777 Inf 0 0 0.000219512858481393 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3644 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ala195Ser Rv1129c_p.Ala195Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4303 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3598 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ala20Thr Rv1129c_p.Ala20Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ala216Pro Rv1129c_p.Ala216Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4329 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ala230Ser Rv1129c_p.Ala230Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4340 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3631 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ala230Thr Rv1129c_p.Ala230Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 6 3 16804 30529 0.000356930398572278 0.000130998068917797 0.000776724091447791 0.999901742434167 0.999712876815577 0.99997973646933 0.666666666666666 0.29929505620854 0.925145368580308 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.39712267122736 0.556919062075511 774 4649 False False 3.63353963342061 0.775880513842457 22.4552956007886 0 0 0.000219499796783869 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 3 3 11499 23704 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.99987345509765 0.999630227076139 0.999973902638554 0.5 0.118117248757025 0.881882751242974 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98955019326111 0.555672530966789 475.5 3890 False False 0 0 0 0 0 0 0 2.06139664318636 0.276050319534324 15.3984166853777 0 0 0.000320748571273651 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ala239Thr Rv1129c_p.Ala239Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4341 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3632 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ala239Val Rv1129c_p.Ala239Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 70.7668929171829 1 1627.5 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 0 0 0.000219447565534303 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 80.2910622977969 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ala269Ser Rv1129c_p.Ala269Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ala269Val Rv1129c_p.Ala269Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4430 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3705 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ala296Gly Rv1129c_p.Ala296Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4330 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3624 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ala342Ser Rv1129c_p.Ala342Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ala351Val Rv1129c_p.Ala351Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 2 2 16808 30530 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999934494956111 0.999763393503742 0.99999206693684 0.5 0.067585986488543 0.932414013511457 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.67174719181657 0.54201215115422 740.5 4649 False False 1.8163969538315 0.131636449523742 25.0652602654423 0 0 0.000219447565534303 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 80.2910622977969 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ala353Gly Rv1129c_p.Ala353Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4364 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3650 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ala373Thr Rv1129c_p.Ala373Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 6 16810 30526 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 1.9819581831673 0.168446574692961 237.5 4649 False False 0 0 1.54251408011679 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 6 11502 23701 0 0 0.000320664925697395 0.9997469101953 0.999449212060655 0.99990711502044 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 2.24903207808669 0.180419790287488 167.5 3890 False False 0 0 0 0 0 0 0 0 0 1.75038628279554 0 0 0.000320664925697395 0.9997469101953 0.999449212060655 0.99990711502044 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ala383Glu Rv1129c_p.Ala383Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 3 5 16807 30527 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999836237390279 0.999617874429585 0.999946824656822 0.375 0.0852334141372535 0.755136783633448 0 0 0.707598226178713 0 0 0.521823750104981 0 0 4.39604951493467 0.556926098551628 787 4649 False False 1.08979591836734 0.169210020231233 5.60160594690905 0 0 0.000219460621016169 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 3 11499 23704 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.99987345509765 0.999630227076139 0.999973902638554 0.5 0.118117248757025 0.881882751242974 0 0 0.975 0 0 0.707598226178713 0 0 80.2982433594846 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06139664318636 0.276050319534324 15.3984166853777 0 0 0.000320748571273651 0.99987345509765 0.999630227076139 0.999973902638554 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ala383Ser Rv1129c_p.Ala383Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ala383Thr Rv1129c_p.Ala383Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 9.67028206568003 0.541992006917746 476.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ala383Val Rv1129c_p.Ala383Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4407 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3686 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ala400Ser Rv1129c_p.Ala400Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ala400Thr Rv1129c_p.Ala400Thr 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 33 16806 30499 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.998919166775841 0.99848244004434 0.999255890978622 0.108108108108108 0.0302519650687496 0.254175936077478 NA NA NA 0 0 0.105762810074579 NA NA NA NA 4274 4649 False False 0.219971943642061 0.0565785664034625 0.618649223561911 0 0 0.000219473678051534 0.998919166775841 0.99848244004434 0.999255890978622 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 26 11501 23681 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.99890327751297 0.998393457445096 0.999283463292248 0.037037037037037 0.000937257091944708 0.189705617413044 NA NA NA 0 0 0.132274604497754 NA NA NA NA 3575 3890 False False 0 0 0 0 0 0 0 0.0791937824804532 0.00193562529301197 0.482202433719514 0 0 0.000320692802708327 0.99890327751297 0.998393457445096 0.999283463292248 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ala445Pro Rv1129c_p.Ala445Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4369 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3655 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ala445Thr Rv1129c_p.Ala445Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4383 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ala456Val Rv1129c_p.Ala456Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4370 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ala468Thr Rv1129c_p.Ala468Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 70.7668929171829 1 1627.5 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 0 0 0.000219447565534303 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 80.2980353694986 1 1214.5 3890 False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 0 0 0.000320720684566658 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ala473Thr Rv1129c_p.Ala473Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ala73Thr Rv1129c_p.Ala73Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 2.75133392880791 0.304355565478378 305.5 4649 False False 0 0 1.9820231071276 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 4.98803779447094 0.555669835711629 381 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ala82Thr Rv1129c_p.Ala82Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4308 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3602 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Arg112Gln Rv1129c_p.Arg112Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Arg112Trp Rv1129c_p.Arg112Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Arg126Trp Rv1129c_p.Arg126Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 4 6 16806 30526 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999803484868334 0.999572318737888 0.999927879105266 0.4 0.121552258119827 0.737621923393055 0 0 0.602364635616474 0 0 0.4592581264399 0 0 2.751898698109 0.304360138688444 359 4649 False False 1.21091673608631 0.25129786177201 5.10706056868951 0 0 0.000219473678051534 0.999803484868334 0.999572318737888 0.999927879105266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 4 2 11498 23705 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 0.999915636731767 0.999695284447545 0.999989783053538 0.666666666666666 0.222778095503512 0.956728131707258 0 0 0.975 0 0 0.841886116991581 0 0 80.3086017072691 1 1214.5 3890 False False 0 0 0 0 0 0 0 4.12332579579057 0.59082359813584 45.5855088556076 0 0 0.000320776462830572 0.999915636731767 0.999695284447545 0.999989783053538 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Arg140His Rv1129c_p.Arg140His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Arg140Pro Rv1129c_p.Arg140Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Arg151Gln Rv1129c_p.Arg151Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Arg165His Rv1129c_p.Arg165His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Arg165Leu Rv1129c_p.Arg165Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4316 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3610 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Arg201Gln Rv1129c_p.Arg201Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4422 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Arg201Trp Rv1129c_p.Arg201Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Arg228Trp Rv1129c_p.Arg228Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 80.2910622977969 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Arg238Cys Rv1129c_p.Arg238Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 8 0 16802 30532 0.000475907198096371 0.00020548462525215 0.000937510381255989 1 0.999879187193184 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 4389 4649 False False Inf 3.10133467016734 Inf 0 0 0.000219525921733526 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 8 0 11494 23707 0.000695531211963136 0.000300327312744212 0.00137001129783907 1 0.999844409142079 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 3669 3890 False False 0 0 0 0 0 0 0 Inf 3.51981666109462 Inf 0 0 0.000320888077582845 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Arg274Pro Rv1129c_p.Arg274Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4365 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3651 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Arg290His Rv1129c_p.Arg290His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Arg294Cys Rv1129c_p.Arg294Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 6 16809 30526 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999803484868334 0.999572318737888 0.999927879105266 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.975 0 0 0.4592581264399 0 0 70.7511120407489 1 1627.5 4649 False False 0.302675154183274 0.00658396461982027 2.49513982006856 0 0 0.000219434511605659 0.999803484868334 0.999572318737888 0.999927879105266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 6 11501 23701 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.9997469101953 0.999449212060655 0.99990711502044 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.975 0 0 0.4592581264399 0 0 80.2741494968233 1 1214.5 3890 False False 0 0 0 0 0 0 0 0.343462887285163 0.00747035147172492 2.83150389371471 0 0 0.000320692802708327 0.9997469101953 0.999449212060655 0.99990711502044 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Arg294Gly Rv1129c_p.Arg294Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4317 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3611 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Arg294Ser Rv1129c_p.Arg294Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4366 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3652 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Arg300Cys Rv1129c_p.Arg300Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4280 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3580 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Arg300Ser Rv1129c_p.Arg300Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4342 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3633 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Arg308Cys Rv1129c_p.Arg308Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 70.7603724184383 1 1627.5 4649 False False 0.908144446427509 0.0153974005043644 17.4461131425891 0 0 0.000219434511605659 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 80.2876797383181 1 1214.5 3890 False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 0 0 0.000320692802708327 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Arg308His Rv1129c_p.Arg308His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4393 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3674 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Arg309Gln Rv1129c_p.Arg309Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Arg309Trp Rv1129c_p.Arg309Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 9.67028206568003 0.541992006917746 476.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Arg330Gln Rv1129c_p.Arg330Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Arg330Leu Rv1129c_p.Arg330Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4281 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3581 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Arg358Trp Rv1129c_p.Arg358Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 4 3 16806 30529 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999901742434167 0.999712876815577 0.99997973646933 0.571428571428571 0.184051567640083 0.901011721557492 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.39659924453693 0.556922492050807 776 4649 False False 2.42207148240707 0.409695730236002 16.540132512068 0 0 0.000219473678051534 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 3 2 11499 23705 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.999915636731767 0.999695284447545 0.999989783053538 0.6 0.146632799634673 0.947255049473683 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.9746468441883 1 1214.5 3890 False False 0 0 0 0 0 0 0 3.09222541090529 0.354154889835857 37.0377673791385 0 0 0.000320748571273651 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Arg3fs Rv1129c_p.Arg3fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4331 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Arg3Gln Rv1129c_p.Arg3Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 7 16810 30525 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 0 0 0.409616397225003 0 0 0.521823750104981 0 0 0.409616397225003 0 0 1.98189325920797 0.168444418238817 233.5 4649 False False 0 0 1.26007067420399 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 3.12221861743114 0.310788655266302 237.5 3890 False False 0 0 0 0 0 0 0 0 0 2.24912710990902 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Arg452Gln Rv1129c_p.Arg452Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4431 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3706 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Arg466Cys Rv1129c_p.Arg466Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Asn166Asp Rv1129c_p.Asn166Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 26 13 16784 30519 0.0015466983938132 0.00101059577405045 0.00226545603351431 0.999574217214725 0.999272008529012 0.999773269742809 0.666666666666666 0.49782773530109 0.809119020953654 0 0 0.369416647552819 0 0 0.24705263800047 0 0 1.06540526945752 0.0571645329069861 168 4649 False False 3.63667778836987 1.80192070238503 7.71054964613638 0 0 0.000219761326426665 0.999574217214725 0.999272008529012 0.999773269742809 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 19 10 11483 23697 0.00165188662841245 0.000994827479836083 0.00257842889005257 0.999578183658835 0.999224402000993 0.999797704727851 0.655172413793103 0.456694272332056 0.820616350764888 0 0 0.4592581264399 0 0 0.30849710781876 0 0 1.75298560143754 0.186802451860486 202 3890 False False 0 0 0 0 0 0 0 3.92095271270573 1.73394700581415 9.44176051271008 0 0 0.000321195419037164 0.999578183658835 0.999224402000993 0.999797704727851 5 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Asn166Ser Rv1129c_p.Asn166Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Asn211Asp Rv1129c_p.Asn211Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4318 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3612 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 4 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Asn211Ser Rv1129c_p.Asn211Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Asn279Asp Rv1129c_p.Asn279Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4367 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3653 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Asn411Asp Rv1129c_p.Asn411Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Asn411Tyr Rv1129c_p.Asn411Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 21 28 16789 30504 0.00124925639500297 0.000773470498752546 0.00190899053306069 0.999082929385562 0.99867484826652 0.999390529439302 0.428571428571428 0.288195224247809 0.577895947964087 0 0 0.841886116991581 0 0 0.123436118500263 0 0 9.67444297107336 0.542049208614782 761 4649 False False 1.36267794389183 0.73536520888699 2.48826458981241 0 0 0.000219695885606983 0.999082929385562 0.99867484826652 0.999390529439302 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 18 26 11484 23681 0.00156494522691705 0.000927741172595553 0.00247216477869727 0.99890327751297 0.998393457445096 0.999283463292248 0.409090909090909 0.263379425081303 0.567503572747829 0 0 0.841886116991581 0 0 0.132274604497754 0 0 10.9778512432348 1 504 3890 False False 0 0 0 0 0 0 0 1.42759826380516 0.736961688613401 2.70701637263403 0 0 0.000321167454579243 0.99890327751297 0.998393457445096 0.999283463292248 3 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Asn451Lys Rv1129c_p.Asn451Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Asn5fs Rv1129c_p.Asn5fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 4 6 16806 30526 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999803484868334 0.999572318737888 0.999927879105266 0.4 0.121552258119827 0.737621923393055 0 0 0.841886116991581 0 0 0.4592581264399 0 0 9.67163112351376 0.542010553936984 735 4649 False False 1.21091673608631 0.25129786177201 5.10706056868951 0 0 0.000219473678051534 0.999803484868334 0.999572318737888 0.999927879105266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 3 11499 23704 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.99987345509765 0.999630227076139 0.999973902638554 0.5 0.118117248757025 0.881882751242974 0 0 0.975 0 0 0.707598226178713 0 0 80.2982433594846 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06139664318636 0.276050319534324 15.3984166853777 0 0 0.000320748571273651 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Asn5Lys Rv1129c_p.Asn5Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4415 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3694 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Asn5Ser Rv1129c_p.Asn5Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 2.75133392880791 0.304355565478378 305.5 4649 False False 0 0 1.9820231071276 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Asp160Ala Rv1129c_p.Asp160Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 26 1 25 74 41 16736 30491 0.00440214158239143 0.00345816149790666 0.00552337665867231 0.998657146600288 0.998178703998069 0.999036178211222 0.643478260869565 0.548776534117802 0.730593979685142 0.0384615384615384 0.00097328789333503 0.196369646762539 0.0238095238095238 0.000602623301603574 0.125658557174992 0.0728752390057361 0.00177902658368881 0.44525805224184 0.000278328795787924 59 4649 True False 3.28827297952711 2.21470208109723 4.94319795599073 5.97478640138615e-05 1.51268380446711e-06 0.000332848330922974 0.998657146600288 0.998178703998069 0.999036178211222 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 15 0 15 52 26 11450 23681 0.00452095287776038 0.00337825195874347 0.00592445285331685 0.99890327751297 0.998393457445096 0.999283463292248 0.666666666666666 0.550833311204021 0.769414760370696 0 0 0.218019360910534 0 0 0.132274604497754 0 0 0.576769273965972 0.0041574076535782 66 3890 False False 0 0 0 0 0 0 0 4.13641921397379 2.53469431189293 6.90512482145928 0 0 0.000322120985979758 0.99890327751297 0.998393457445096 0.999283463292248 15 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Asp160Asn Rv1129c_p.Asp160Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 8 2 16802 30530 0.000475907198096371 0.00020548462525215 0.000937510381255989 0.999934494956111 0.999763393503742 0.99999206693684 0.8 0.443904537692358 0.974789273673166 0 0 0.975 0 0 0.841886116991581 0 0 70.7898197898872 1 1627.5 4649 False False 7.26818235924294 1.45017637426587 70.3957327614674 0 0 0.000219525921733526 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 5 1 11497 23706 0.00043470700747696 0.000141162766530747 0.00101416710312943 0.999957818365883 0.999765001636458 0.999998932054057 0.833333333333333 0.358765421002325 0.99578925548551 0 0 0.975 0 0 0.975 0 0 80.3189618536173 1 1214.5 3890 False False 0 0 0 0 0 0 0 10.3096459946072 1.15337945963023 486.419600220716 0 0 0.000320804359238686 0.999957818365883 0.999765001636458 0.999998932054057 2 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Asp160Glu Rv1129c_p.Asp160Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 4344 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 0 0 0.000219447565534303 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3636 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Asp160Gly Rv1129c_p.Asp160Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 7 3 16803 30529 0.000416418798334324 0.000167437820935922 0.000857792460925722 0.999901742434167 0.999712876815577 0.99997973646933 0.7 0.347547149940002 0.933260488822265 0 0 0.841886116991581 0 0 0.707598226178713 0 0 9.67430425317402 0.542047309778124 759.5 4649 False False 4.23938185641452 0.967624775502593 25.4084961789154 0 0 0.000219512858481393 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 4 3 11498 23704 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 0.99987345509765 0.999630227076139 0.999973902638554 0.571428571428571 0.184051567640083 0.901011721557492 0 0 0.841886116991581 0 0 0.707598226178713 0 0 10.9751375007814 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.74876790166405 0.464911430750807 18.766829223129 0 0 0.000320776462830572 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Asp164His Rv1129c_p.Asp164His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4332 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Asp191Ala Rv1129c_p.Asp191Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4377 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Asp191Asn Rv1129c_p.Asp191Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Asp191Gly Rv1129c_p.Asp191Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 13 9 16797 30523 0.000773349196906603 0.000411838091387593 0.00132208760075144 0.999705227302502 0.999440503684993 0.999865202576615 0.59090909090909 0.363546961729731 0.79290687700285 0 0 0.369416647552819 0 0 0.336267116879942 0 0 1.06472016246047 0.0571676498088303 169 4649 False False 2.62480072499718 1.03769739727851 6.96026532354986 0 0 0.000219591261323031 0.999705227302502 0.999440503684993 0.999865202576615 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 13 9 11489 23698 0.00113023821944009 0.000601937155487611 0.00193196626494298 0.999620365292951 0.999279457952852 0.99982639261309 0.59090909090909 0.363546961729731 0.79290687700285 0 0 0.369416647552819 0 0 0.336267116879942 0 0 1.20863297466018 0.0599679673019816 123 3890 False False 0 0 0 0 0 0 0 2.97941025715418 1.17777391402501 7.89965824066124 0 0 0.000321027705298525 0.999620365292951 0.999279457952852 0.99982639261309 3 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Asp200Ala Rv1129c_p.Asp200Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4374 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3658 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Asp200Asn Rv1129c_p.Asp200Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.67117271135833 0.542004252564565 721 4649 False False 0.908144446427509 0.0153974005043644 17.4461131425891 0 0 0.000219434511605659 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Asp200His Rv1129c_p.Asp200His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Asp209Ala Rv1129c_p.Asp209Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Asp209Gly Rv1129c_p.Asp209Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4309 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Asp214Asn Rv1129c_p.Asp214Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 2 16808 30530 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999934494956111 0.999763393503742 0.99999206693684 0.5 0.067585986488543 0.932414013511457 1 0.158113883008419 1 0.5 0.067585986488543 0.932414013511457 Inf 0.341128396083888 Inf 0.126084661690076 226.5 4649 False False 1.8163969538315 0.131636449523742 25.0652602654423 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 2 11500 23705 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999915636731767 0.999695284447545 0.999989783053538 0.5 0.067585986488543 0.932414013511457 1 0.158113883008419 1 0.5 0.067585986488543 0.932414013511457 Inf 0.387057584255602 Inf 0.106724286934948 157 3890 False False 0 0 0 0 0 0 0 2.06130434782608 0.149383229063395 28.4413197127326 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999915636731767 0.999695284447545 0.999989783053538 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Asp223Glu Rv1129c_p.Asp223Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4319 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3613 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Asp223His Rv1129c_p.Asp223His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Asp262Gly Rv1129c_p.Asp262Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 3 3 16807 30529 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999901742434167 0.999712876815577 0.99997973646933 0.5 0.118117248757025 0.881882751242974 0 0 0.841886116991581 0 0 0.707598226178713 0 0 9.67200545083345 0.542015701685608 745.5 4649 False False 1.81644552864877 0.243258979140325 13.5672775646283 0 0 0.000219460621016169 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 3 11501 23704 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.99987345509765 0.999630227076139 0.999973902638554 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 10.9722796976426 1 1214.5 3890 False False 0 0 0 0 0 0 0 0.687012723531287 0.0130900577164196 8.55773267307823 0 0 0.000320692802708327 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Asp302Asn Rv1129c_p.Asp302Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4358 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3645 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Asp387Glu Rv1129c_p.Asp387Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Asp387Gly Rv1129c_p.Asp387Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 16809 30529 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999901742434167 0.999712876815577 0.99997973646933 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.39581433818102 0.556927644280045 795 4649 False False 0.605409800305391 0.0115361654751757 7.54087213596152 0 0 0.000219434511605659 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 80.2910622977969 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Asp419Asn Rv1129c_p.Asp419Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4378 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Asp41Asn Rv1129c_p.Asp41Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4347 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3638 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Asp81Ala Rv1129c_p.Asp81Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4282 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3582 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Asp87Glu Rv1129c_p.Asp87Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 80.2910622977969 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Gln105Arg Rv1129c_p.Gln105Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Gln105Glu Rv1129c_p.Gln105Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 2 16807 30530 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999934494956111 0.999763393503742 0.99999206693684 0.6 0.146632799634673 0.947255049473683 0 0 0.975 0 0 0.841886116991581 0 0 70.7687834529204 1 1627.5 4649 False False 2.72475754150056 0.312074221533576 32.6324551811023 0 0 0.000219460621016169 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 3687 3890 False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 0 0 0.000320720684566658 0.999957818365883 0.999765001636458 0.999998932054057 8 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Gln105Pro Rv1129c_p.Gln105Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 4 1 16806 30531 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999967247478055 0.999817528289014 0.999999170778282 0.8 0.28358206388191 0.994949236620532 0 0 0.975 0 0 0.975 0 0 70.7753052263996 1 1627.5 4649 False False 7.26669046769011 0.71899465830523 357.208630433948 0 0 0.000219473678051534 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 1 11499 23706 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.999957818365883 0.999765001636458 0.999998932054057 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 80.3050096524922 1 1214.5 3890 False False 0 0 0 0 0 0 0 6.18471171406209 0.496496186771195 324.103527365594 0 0 0.000320748571273651 0.999957818365883 0.999765001636458 0.999998932054057 2 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Gln237Pro Rv1129c_p.Gln237Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Gln329Pro Rv1129c_p.Gln329Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 5 7 16805 30525 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 0.99977073234639 0.999527678427408 0.999907817703152 0.416666666666666 0.15165222980843 0.723330314317894 0 0 0.521823750104981 0 0 0.409616397225003 0 0 1.98248298242793 0.168464015851288 279 4649 False False 1.29744548816253 0.324660110943214 4.74943003331221 0 0 0.000219486736640675 0.99977073234639 0.999527678427408 0.999907817703152 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 4 5 11498 23702 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 0.999789091829417 0.999507879904061 0.999931515258336 0.444444444444444 0.136995662265166 0.787991493221131 0 0 0.707598226178713 0 0 0.521823750104981 0 0 4.98956317931082 0.555672552596824 477 3890 False False 0 0 0 0 0 0 0 1.64912158636284 0.327175514256965 7.66332787722062 0 0 0.000320776462830572 0.999789091829417 0.999507879904061 0.999931515258336 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Gln384His Rv1129c_p.Gln384His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 70.7668929171829 1 1627.5 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 0 0 0.000219447565534303 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Gln74His Rv1129c_p.Gln74His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4390 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3670 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 3 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Glu107Asp Rv1129c_p.Glu107Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 10 2 16800 30530 0.000594883997620464 0.000285305684944214 0.00109373983334496 0.999934494956111 0.999763393503742 0.99999206693684 0.833333333333333 0.515862251314033 0.979137474539907 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6763454929231 0.542075378623452 764 4649 False False 9.08630952380952 1.93595242258509 85.4347314054855 0 0 0.000219552052902727 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 10 1 11492 23706 0.000869414014953921 0.000416994043678715 0.001598300185227 0.999957818365883 0.999765001636458 0.999998932054057 0.909090909090909 0.587220083011617 0.997701027786185 0 0 0.975 0 0 0.975 0 0 80.3538635761453 1 1214.5 3890 False False 0 0 0 0 0 0 0 20.6282631395753 2.93373003427251 891.367911239421 0 0 0.000320943914091465 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Glu115Ala Rv1129c_p.Glu115Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4324 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3618 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Glu115Lys Rv1129c_p.Glu115Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4310 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3603 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Glu133Asp Rv1129c_p.Glu133Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 17 7 16793 30525 0.00101130279595478 0.000589228022589122 0.0016187015795436 0.99977073234639 0.999527678427408 0.999907817703152 0.708333333333333 0.489052186142167 0.873847911476308 0 0 0.602364635616474 0 0 0.409616397225003 0 0 2.75393904915778 0.304376817133662 368 4649 False False 4.41446691223383 1.73934455248296 12.5939596556495 0 0 0.000219643561005912 0.99977073234639 0.999527678427408 0.999907817703152 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 15 5 11487 23702 0.00130412102243088 0.000730084557867185 0.00215003854003137 0.999789091829417 0.999507879904061 0.999931515258336 0.75 0.508954128292042 0.913428530898565 0 0 0.707598226178713 0 0 0.521823750104981 0 0 4.99434308133463 0.555681240358978 489 3890 False False 0 0 0 0 0 0 0 6.19012797074954 2.1377185694887 21.7744689410009 0 0 0.000321083590414119 0.999789091829417 0.999507879904061 0.999931515258336 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Glu133Lys Rv1129c_p.Glu133Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 7 5 16803 30527 0.000416418798334324 0.000167437820935922 0.000857792460925722 0.999836237390279 0.999617874429585 0.999946824656822 0.583333333333333 0.276669685682105 0.848347770191569 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.98284887205491 0.168476194402006 280 4649 False False 2.54346247693864 0.694762351860352 10.1613479269948 0 0 0.000219512858481393 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 2 5 11500 23702 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999789091829417 0.999507879904061 0.999931515258336 0.285714285714285 0.0366925661760855 0.709579136262657 0 0 0.521823750104981 0 0 0.521823750104981 0 0 2.24951890955832 0.18044632709958 195.5 3890 False False 0 0 0 0 0 0 0 0.824417391304347 0.0784856369585262 5.0365353499031 0 0 0.000320720684566658 0.999789091829417 0.999507879904061 0.999931515258336 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Glu135Ala Rv1129c_p.Glu135Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 15 0 15 25 28 16785 30504 0.00148720999405116 0.000962667916776425 0.00219463783814356 0.999082929385562 0.99867484826652 0.999390529439302 0.471698113207547 0.333024695678895 0.6136447928059 0 0 0.218019360910534 0 0 0.123436118500263 0 0 0.506768783642745 0.00194745880898479 76 4649 False False 1.62262223924422 0.907073175653719 2.88745466236084 0 0 0.000219748235144057 0.999082929385562 0.99867484826652 0.999390529439302 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 13 0 13 11 25 11491 23682 0.000956355416449313 0.000477502787107626 0.00171053820723243 0.998945459147087 0.998443680572118 0.999317444144018 0.305555555555555 0.163473984628493 0.481070630000079 0 0 0.24705263800047 0 0 0.137185171530712 0 0 0.676373304519992 0.00722687293768237 73 3890 False False 0 0 0 0 0 0 0 0.906803585414672 0.4026097854714 1.9113785376308 0 0 0.000320971839633333 0.998945459147087 0.998443680572118 0.999317444144018 3 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Glu135Gln Rv1129c_p.Glu135Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 4.39540875925228 0.556930310247326 910.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Glu135Gly Rv1129c_p.Glu135Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 8 5 16802 30527 0.000475907198096371 0.00020548462525215 0.000937510381255989 0.999836237390279 0.999617874429585 0.999946824656822 0.615384615384615 0.315777602914063 0.861420661109839 0 0 0.707598226178713 0 0 0.521823750104981 0 0 4.39735807378403 0.556917520140823 772 4649 False False 2.90698726342102 0.838334102961652 11.2954727017352 0 0 0.000219525921733526 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 3 2 11499 23705 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.999915636731767 0.999695284447545 0.999989783053538 0.6 0.146632799634673 0.947255049473683 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.9746468441883 1 1214.5 3890 False False 0 0 0 0 0 0 0 3.09222541090529 0.354154889835857 37.0377673791385 0 0 0.000320748571273651 0.999915636731767 0.999695284447545 0.999989783053538 7 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Glu135Lys Rv1129c_p.Glu135Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 12 4 16798 30528 0.000713860797144556 0.000368914962606047 0.00124663876852724 0.999868989912223 0.999664596427238 0.999964303043777 0.75 0.476229180103872 0.927337961747117 0 0 0.707598226178713 0 0 0.602364635616474 0 0 4.39854959080883 0.556909734962144 767 4649 False False 5.45207762828908 1.65200923603103 23.1963654568766 0 0 0.000219578190293692 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 5 3 11497 23704 0.00043470700747696 0.000141162766530747 0.00101416710312943 0.99987345509765 0.999630227076139 0.999973902638554 0.625 0.244863216366551 0.914766585862746 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.99041850782513 0.555674089716787 481.5 3890 False False 0 0 0 0 0 0 0 3.43625873416253 0.668393407932569 22.1300557847574 0 0 0.000320804359238686 0.99987345509765 0.999630227076139 0.999973902638554 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Glu146Lys Rv1129c_p.Glu146Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Glu146Val Rv1129c_p.Glu146Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4275 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Glu156Gly Rv1129c_p.Glu156Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4416 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3695 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Glu157Gly Rv1129c_p.Glu157Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4435 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3708 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Glu268Lys Rv1129c_p.Glu268Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4333 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3625 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Glu291Gln Rv1129c_p.Glu291Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Glu297Gln Rv1129c_p.Glu297Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4417 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3696 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Glu297Val Rv1129c_p.Glu297Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4391 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3671 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Glu440Ala Rv1129c_p.Glu440Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4400 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3679 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 4 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Glu471Asp Rv1129c_p.Glu471Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Glu483Ala Rv1129c_p.Glu483Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 2.75133392880791 0.304355565478378 305.5 4649 False False 0 0 1.9820231071276 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 3.12221861743114 0.310788655266302 237.5 3890 False False 0 0 0 0 0 0 0 0 0 2.24912710990902 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Glu483Lys Rv1129c_p.Glu483Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 6 16810 30526 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 0 0 0.4592581264399 0 0 0.602364635616474 0 0 0.4592581264399 0 0 2.75124380141528 0.304354836583622 299.5 4649 False False 0 0 1.54251408011679 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 6 11502 23701 0 0 0.000320664925697395 0.9997469101953 0.999449212060655 0.99990711502044 0 0 0.4592581264399 0 0 0.602364635616474 0 0 0.4592581264399 0 0 3.12208687486085 0.310785326665151 232 3890 False False 0 0 0 0 0 0 0 0 0 1.75038628279554 0 0 0.000320664925697395 0.9997469101953 0.999449212060655 0.99990711502044 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Glu67Ala Rv1129c_p.Glu67Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4288 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Glu67Lys Rv1129c_p.Glu67Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Glu98Ala Rv1129c_p.Glu98Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 9.66996583219897 0.541987658825864 457.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 10.9713274274722 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Glu98Gly Rv1129c_p.Glu98Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 5 2 16805 30530 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 0.999934494956111 0.999763393503742 0.99999206693684 0.714285714285714 0.290420863737342 0.963307433823914 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.67347104264285 0.542035853380699 756.5 4649 False False 4.54180303481106 0.743433860385311 47.6944906777554 0 0 0.000219486736640675 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Glu98Lys Rv1129c_p.Glu98Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 15 0 15 2 17 16808 30515 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999443207126948 0.999108669858669 0.999675615241488 0.105263157894736 0.0130121643717774 0.331376664456765 0 0 0.218019360910534 0 0 0.195064322969093 0 0 0.506257757082619 0.00194379415606741 75 4649 False False 0.213588767253688 0.0239171167139851 0.899977742126277 0 0 0.000219447565534303 0.999443207126948 0.999108669858669 0.999675615241488 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 13 0 13 2 15 11500 23692 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999367275488252 0.9989566315242 0.999645827023281 0.117647058823529 0.0145793168403025 0.36440916210125 0 0 0.24705263800047 0 0 0.218019360910534 0 0 0.676129269914933 0.00722084232028623 71 3890 False False 0 0 0 0 0 0 0 0.274689855072463 0.0304794343438515 1.18152047804442 0 0 0.000320720684566658 0.999367275488252 0.9989566315242 0.999645827023281 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Gly103Ala Rv1129c_p.Gly103Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Gly103Asp Rv1129c_p.Gly103Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Gly117Ala Rv1129c_p.Gly117Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4296 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Gly184Ala Rv1129c_p.Gly184Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4401 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3680 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Gly188Arg Rv1129c_p.Gly188Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 11 16809 30521 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999639722258614 0.999355455254591 0.999820137367966 0.0833333333333333 0.00210759323186022 0.384796165150944 NA NA NA 0 0 0.284914152918154 NA NA NA NA 4289 4649 False False 0.165068496855039 0.00383877950020004 1.13592616933053 0 0 0.000219434511605659 0.999639722258614 0.999355455254591 0.999820137367966 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 10 11501 23697 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999578183658835 0.999224402000993 0.999797704727851 0.0909090909090909 0.00229897221381426 0.412779916988382 NA NA NA 0 0 0.30849710781876 NA NA NA NA 3588 3890 False False 0 0 0 0 0 0 0 0.206042952786714 0.00475133046717015 1.44869994779485 0 0 0.000320692802708327 0.999578183658835 0.999224402000993 0.999797704727851 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Gly188Ser Rv1129c_p.Gly188Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.75142405620251 0.304356294847217 327.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12235036001139 0.310791984491028 261 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Gly19Ala Rv1129c_p.Gly19Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4345 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3637 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Gly236Glu Rv1129c_p.Gly236Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4375 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3659 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Gly250Arg Rv1129c_p.Gly250Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4402 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3681 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Gly271Ser Rv1129c_p.Gly271Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 1 4 16809 30528 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999868989912223 0.999664596427238 0.999964303043777 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.75158776187525 0.30435761959971 350.5 4649 False False 0.454042477244333 0.00922341562850508 4.58878013974823 0 0 0.000219434511605659 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.9727417274169 1 1214.5 3890 False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 0 0 0.000320692802708327 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Gly271Val Rv1129c_p.Gly271Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4304 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3599 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Gly311Glu Rv1129c_p.Gly311Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 2 10 16808 30522 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999672474780558 0.999397752220648 0.999842928110511 0.166666666666666 0.0208625254600923 0.484137748685967 0 0 0.4592581264399 0 0 0.30849710781876 0 0 1.54249550368594 0.0957774999216848 191 4649 False False 0.363184198000951 0.0386890372209022 1.70456922948828 0 0 0.000219447565534303 0.999672474780558 0.999397752220648 0.999842928110511 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 6 11502 23701 0 0 0.000320664925697395 0.9997469101953 0.999449212060655 0.99990711502044 0 0 0.4592581264399 0 0 0.707598226178713 0 0 0.4592581264399 0 0 4.98761680763255 0.55566908871896 373.5 3890 False False 0 0 0 0 0 0 0 0 0 1.75038628279554 0 0 0.000320664925697395 0.9997469101953 0.999449212060655 0.99990711502044 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Gly311Val Rv1129c_p.Gly311Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4403 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3682 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Gly360Asp Rv1129c_p.Gly360Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 3 2 16807 30530 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999934494956111 0.999763393503742 0.99999206693684 0.6 0.146632799634673 0.947255049473683 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.67232174050862 0.542020050820051 749.5 4649 False False 2.72475754150056 0.312074221533576 32.6324551811023 0 0 0.000219460621016169 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 1 11499 23706 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.999957818365883 0.999765001636458 0.999998932054057 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 80.3050096524922 1 1214.5 3890 False False 0 0 0 0 0 0 0 6.18471171406209 0.496496186771195 324.103527365594 0 0 0.000320748571273651 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Gly360Ser Rv1129c_p.Gly360Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4371 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3656 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Gly360Val Rv1129c_p.Gly360Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 3 16809 30529 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999901742434167 0.999712876815577 0.99997973646933 0.25 0.00630946320970987 0.805879550316756 0 0 0.975 0 0 0.707598226178713 0 0 70.7580573242674 1 1627.5 4649 False False 0.605409800305391 0.0115361654751757 7.54087213596152 0 0 0.000219434511605659 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 80.2910622977969 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Gly361Ala Rv1129c_p.Gly361Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4360 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3647 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Gly361Asp Rv1129c_p.Gly361Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4379 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3661 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Gly361Cys Rv1129c_p.Gly361Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 4 2 16806 30530 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999934494956111 0.999763393503742 0.99999206693684 0.666666666666666 0.222778095503512 0.956728131707258 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4394 4649 False False 3.63322622872783 0.520625747830046 40.1764939558657 0 0 0.000219473678051534 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3675 3890 False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 0 0 0.000320692802708327 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Gly361Ser Rv1129c_p.Gly361Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 70.7668929171829 1 1627.5 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 0 0 0.000219447565534303 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3634 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Gly361Val Rv1129c_p.Gly361Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Gly402Ala Rv1129c_p.Gly402Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4276 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3576 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Gly402Arg Rv1129c_p.Gly402Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4423 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Gly402Glu Rv1129c_p.Gly402Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 21 2 19 14 26 16796 30506 0.000832837596668649 0.000455392489979272 0.00139696554892221 0.999148434429451 0.998752506314373 0.99944365605196 0.35 0.206282490870766 0.51684445364899 0.0952380952380952 0.0117493178844458 0.303774406913924 0.0714285714285714 0.00877049670352713 0.23503477317459 0.191185871322746 0.0215924247133528 0.792647508455064 0.0112144934578386 110 4649 False False 0.977989264843277 0.471900190755411 1.94352385377291 0.000119061793070603 1.44192607481091e-05 0.000430025253392943 0.999148434429451 0.998752506314373 0.99944365605196 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 17 2 15 14 21 11488 23686 0.00121717962093548 0.000665598145642159 0.00204137811638842 0.999114185683553 0.998646255755329 0.99945158598871 0.4 0.238708110453341 0.5788822781179 0.117647058823529 0.0145793168403025 0.36440916210125 0.0869565217391304 0.0107099660378758 0.280379335909411 0.274907149489322 0.0305035942163142 1.18245536437814 0.0732175353492417 126 3890 False False 0 0 0 0 0 0 0 1.37453574744661 0.646228469348307 2.83539167493309 0.000174064403829416 2.10807020159315e-05 0.000628637533813848 0.999114185683553 0.998646255755329 0.99945158598871 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Gly402Trp Rv1129c_p.Gly402Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Gly404Ala Rv1129c_p.Gly404Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Gly407Asp Rv1129c_p.Gly407Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Gly407Ser Rv1129c_p.Gly407Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.67117271135833 0.542004252564565 721 4649 False False 0.908144446427509 0.0153974005043644 17.4461131425891 0 0 0.000219434511605659 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Gly415Val Rv1129c_p.Gly415Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4384 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3665 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Gly431Arg Rv1129c_p.Gly431Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4297 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3593 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 2 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Gly446Ala Rv1129c_p.Gly446Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4395 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3676 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Gly446Cys Rv1129c_p.Gly446Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4325 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3619 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Gly446Ser Rv1129c_p.Gly446Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4396 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Gly446Val Rv1129c_p.Gly446Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 4 1 16806 30531 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999967247478055 0.999817528289014 0.999999170778282 0.8 0.28358206388191 0.994949236620532 0 0 0.975 0 0 0.975 0 0 70.7753052263996 1 1627.5 4649 False False 7.26669046769011 0.71899465830523 357.208630433948 0 0 0.000219473678051534 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 1 11499 23706 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.999957818365883 0.999765001636458 0.999998932054057 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 80.3050096524922 1 1214.5 3890 False False 0 0 0 0 0 0 0 6.18471171406209 0.496496186771195 324.103527365594 0 0 0.000320748571273651 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Gly474Asp Rv1129c_p.Gly474Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3620 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Gly474Ser Rv1129c_p.Gly474Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Gly474Val Rv1129c_p.Gly474Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Gly96Arg Rv1129c_p.Gly96Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4298 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3594 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.His118Pro Rv1129c_p.His118Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4305 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3600 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.His118Tyr Rv1129c_p.His118Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.His221Gln Rv1129c_p.His221Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.His231Pro Rv1129c_p.His231Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4348 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.His293Asn Rv1129c_p.His293Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4385 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.His355Arg Rv1129c_p.His355Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.67117271135833 0.542004252564565 721 4649 False False 0.908144446427509 0.0153974005043644 17.4461131425891 0 0 0.000219434511605659 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.9727417274169 1 1214.5 3890 False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 0 0 0.000320692802708327 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.His355Gln Rv1129c_p.His355Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.His409Arg Rv1129c_p.His409Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4424 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3700 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ile106Val Rv1129c_p.Ile106Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4290 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ile208Val Rv1129c_p.Ile208Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4283 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3583 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ile242Val Rv1129c_p.Ile242Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ile275fs Rv1129c_p.Ile275fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ile303Leu Rv1129c_p.Ile303Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4320 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3614 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ile303Thr Rv1129c_p.Ile303Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4337 4649 False False 0.908144446427509 0.0153974005043644 17.4461131425891 0 0 0.000219434511605659 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3629 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ile332Leu Rv1129c_p.Ile332Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 9.66996583219897 0.541987658825864 457.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 10.9708654377183 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ile332Met Rv1129c_p.Ile332Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4432 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3707 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ile332Thr Rv1129c_p.Ile332Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4334 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3626 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ile345Met Rv1129c_p.Ile345Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4299 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3595 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ile378Met Rv1129c_p.Ile378Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4346 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ile443Ala Rv1129c_p.Ile443Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4349 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ile443Met Rv1129c_p.Ile443Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4386 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3666 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ile443Thr Rv1129c_p.Ile443Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 6 4 16804 30528 0.000356930398572278 0.000130998068917797 0.000776724091447791 0.999868989912223 0.999664596427238 0.999964303043777 0.6 0.262378076606945 0.878447741880172 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4387 4649 False False 2.72506546060461 0.646076910390347 13.1292748110224 0 0 0.000219499796783869 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3667 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ile443Val Rv1129c_p.Ile443Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.75142405620251 0.304356294847217 327.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12235036001139 0.310791984491028 261 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ile449Val Rv1129c_p.Ile449Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 80.2910622977969 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 2 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ile95Thr Rv1129c_p.Ile95Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3701 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ile95Val Rv1129c_p.Ile95Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Leu127Val Rv1129c_p.Leu127Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Leu134Pro Rv1129c_p.Leu134Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 4 3 16806 30529 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999901742434167 0.999712876815577 0.99997973646933 0.571428571428571 0.184051567640083 0.901011721557492 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.39659924453693 0.556922492050807 776 4649 False False 2.42207148240707 0.409695730236002 16.540132512068 0 0 0.000219473678051534 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Leu172Met Rv1129c_p.Leu172Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Leu172Val Rv1129c_p.Leu172Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Leu190Ser Rv1129c_p.Leu190Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Leu212Arg Rv1129c_p.Leu212Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 2 3 14 4 16796 30528 0.000832837596668649 0.000455392489979272 0.00139696554892221 0.999868989912223 0.999664596427238 0.999964303043777 0.777777777777777 0.52362723426352 0.935907952282333 0.4 0.0527449505263169 0.853367200365326 0.333333333333333 0.0432718682927417 0.777221904496487 1.21171707549416 0.101226793992424 10.5769751372593 1 938.5 4649 False False 6.36151464634436 1.99737703942731 26.5406096746994 0.000119061793070603 1.44192607481091e-05 0.000430025253392943 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 2 3 10 4 11492 23703 0.000869414014953921 0.000416994043678715 0.001598300185227 0.999831273463534 0.999568049920357 0.99995402584539 0.714285714285714 0.418964742816338 0.916110681692872 0.4 0.0527449505263169 0.853367200365326 0.333333333333333 0.0432718682927417 0.777221904496487 1.37504350852767 0.114809725036213 12.0021196491817 0.664127490754708 491 3890 False False 0 0 0 0 0 0 0 5.15641315697876 1.48676997429573 22.5277161275388 0.000174003828084217 2.10733655283736e-05 0.000628418812861097 0.999831273463534 0.999568049920357 0.99995402584539 2 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Leu212Gln Rv1129c_p.Leu212Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4408 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Leu212Pro Rv1129c_p.Leu212Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 6 1 16804 30531 0.000356930398572278 0.000130998068917797 0.000776724091447791 0.999967247478055 0.999817528289014 0.999999170778282 0.857142857142857 0.421276802956804 0.996389703138099 NA NA NA 0 0 0.975 NA NA NA NA 4388 4649 False False 10.9013330159485 1.32231137693091 500.206066508325 0 0 0.000219499796783869 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 6 1 11496 23706 0.000521648408972352 0.000191459062774625 0.00113506056981396 0.999957818365883 0.999765001636458 0.999998932054057 0.857142857142857 0.421276802956804 0.996389703138099 NA NA NA 0 0 0.975 NA NA NA NA 3668 3890 False False 0 0 0 0 0 0 0 12.3726513569937 1.50072525153826 567.507166587209 0 0 0.000320832260499258 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Leu227Phe Rv1129c_p.Leu227Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Leu233Gln Rv1129c_p.Leu233Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Leu265Phe Rv1129c_p.Leu265Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4277 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3577 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Leu299Ser Rv1129c_p.Leu299Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4418 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Leu305Pro Rv1129c_p.Leu305Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4361 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3648 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Leu306Met Rv1129c_p.Leu306Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4335 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3627 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Leu321Phe Rv1129c_p.Leu321Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 5 0 16805 30532 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 1 0.999879187193184 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 4353 4649 False False Inf 1.66460481015123 Inf 0 0 0.000219486736640675 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 5 0 11497 23707 0.00043470700747696 0.000141162766530747 0.00101416710312943 1 0.999844409142079 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 3642 3890 False False 0 0 0 0 0 0 0 Inf 1.88913119689894 Inf 0 0 0.000320804359238686 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Leu420Arg Rv1129c_p.Leu420Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Leu426Ile Rv1129c_p.Leu426Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4425 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Leu426Val Rv1129c_p.Leu426Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4392 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3672 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Leu463Arg Rv1129c_p.Leu463Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Leu477Met Rv1129c_p.Leu477Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4426 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3702 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Leu477Phe Rv1129c_p.Leu477Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4362 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Leu64Met Rv1129c_p.Leu64Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Lys217Asn Rv1129c_p.Lys217Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4397 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3677 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Lys225Asn Rv1129c_p.Lys225Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4270 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3572 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Lys341Asn Rv1129c_p.Lys341Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4433 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Lys425Arg Rv1129c_p.Lys425Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Lys425Thr Rv1129c_p.Lys425Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4311 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3604 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Lys448Thr Rv1129c_p.Lys448Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4363 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3649 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Met1? Rv1129c_p.Met1? 2 start_lost (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 70.7668929171829 1 1627.5 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 0 0 0.000219447565534303 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 80.2910622977969 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Met113Ile Rv1129c_p.Met113Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 4.39540875925228 0.556930310247326 910.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 4.98803779447094 0.555669835711629 381 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Met113Thr Rv1129c_p.Met113Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3605 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Met153Ile Rv1129c_p.Met153Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.67117271135833 0.542004252564565 721 4649 False False 0.908144446427509 0.0153974005043644 17.4461131425891 0 0 0.000219434511605659 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Met153Thr Rv1129c_p.Met153Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Met174Ile Rv1129c_p.Met174Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Met174Val Rv1129c_p.Met174Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.67117271135833 0.542004252564565 721 4649 False False 0.908144446427509 0.0153974005043644 17.4461131425891 0 0 0.000219434511605659 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Met179Ile Rv1129c_p.Met179Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 4.39540875925228 0.556930310247326 910.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3697 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Met234Ile Rv1129c_p.Met234Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4372 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3657 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Phe109Leu Rv1129c_p.Phe109Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 80.2910622977969 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Phe180Leu Rv1129c_p.Phe180Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4312 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3606 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Phe202Tyr Rv1129c_p.Phe202Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 77 0 16733 30532 0.00458060678167757 0.0036165835579759 0.00572169443720038 1 0.999879187193184 1 1 0.953221931839596 1 NA NA NA NA NA NA NA NA NA NA 4338 4649 False False Inf 37.1427761063327 Inf 0 0 0.000220431056438049 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 16 0 11486 23707 0.00139106242392627 0.000795314835170056 0.00225801785882213 1 0.999844409142079 1 1 0.794092785792177 1 NA NA NA NA NA NA NA NA NA NA 3630 3890 False False 0 0 0 0 0 0 0 Inf 7.95612579230723 Inf 0 0 0.000321111540268992 1 0.999844409142079 1 33 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Phe334Leu Rv1129c_p.Phe334Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 19 1 16791 30531 0.00113027959547888 0.000680635004098699 0.00176451134196716 0.999967247478055 0.999817528289014 0.999999170778282 0.95 0.751267237227972 0.99873491050205 0 0 0.975 0 0 0.975 0 0 70.83846135246 1 1627.5 4649 False False 34.5476147936394 5.4908913424451 1425.62113929708 0 0 0.000219669720190561 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 16 1 11486 23706 0.00139106242392627 0.000795314835170056 0.00225801785882213 0.999957818365883 0.999765001636458 0.999998932054057 0.941176470588235 0.713110603332779 0.998511825608733 0 0 0.975 0 0 0.975 0 0 80.3957857027304 1 1214.5 3890 False False 0 0 0 0 0 0 0 33.0224621278077 5.12866478124923 1375.56221955267 0 0 0.000321111540268992 0.999957818365883 0.999765001636458 0.999998932054057 10 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Phe412Leu Rv1129c_p.Phe412Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4291 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3589 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Phe460Leu Rv1129c_p.Phe460Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 9.67028206568003 0.541992006917746 476.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3628 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Phe460Val Rv1129c_p.Phe460Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4404 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3683 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Pro149Leu Rv1129c_p.Pro149Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Pro149Ser Rv1129c_p.Pro149Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4321 4649 False False 0.908144446427509 0.0153974005043644 17.4461131425891 0 0 0.000219434511605659 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3615 3890 False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 0 0 0.000320692802708327 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Pro327Leu Rv1129c_p.Pro327Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Pro333Arg Rv1129c_p.Pro333Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Pro333Ser Rv1129c_p.Pro333Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Pro386Ser Rv1129c_p.Pro386Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Pro408Leu Rv1129c_p.Pro408Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Pro408Ser Rv1129c_p.Pro408Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Pro437Leu Rv1129c_p.Pro437Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Pro461Arg Rv1129c_p.Pro461Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4354 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Pro461Leu Rv1129c_p.Pro461Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4339 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Pro461Ser Rv1129c_p.Pro461Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Pro461Thr Rv1129c_p.Pro461Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4313 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3607 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Pro478Ser Rv1129c_p.Pro478Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Pro8fs Rv1129c_p.Pro8fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Pro8Ser Rv1129c_p.Pro8Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ser119Arg Rv1129c_p.Ser119Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ser119Asn Rv1129c_p.Ser119Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4350 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3639 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ser119Gly Rv1129c_p.Ser119Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4271 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3573 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ser14Leu Rv1129c_p.Ser14Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ser183Cys Rv1129c_p.Ser183Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ser266Asn Rv1129c_p.Ser266Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4300 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3596 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ser266Thr Rv1129c_p.Ser266Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 2.75133392880791 0.304355565478378 305.5 4649 False False 0 0 1.9820231071276 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 3.12221861743114 0.310788655266302 237.5 3890 False False 0 0 0 0 0 0 0 0 0 2.24912710990902 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ser346Leu Rv1129c_p.Ser346Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4410 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3689 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ser357Arg Rv1129c_p.Ser357Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4427 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3703 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ser357Asn Rv1129c_p.Ser357Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 80.2910622977969 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ser357Gly Rv1129c_p.Ser357Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4322 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3616 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ser362Thr Rv1129c_p.Ser362Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ser429Ala Rv1129c_p.Ser429Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4419 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3698 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ser438Thr Rv1129c_p.Ser438Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 80.2910622977969 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ser454Ala Rv1129c_p.Ser454Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4326 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ser475Arg Rv1129c_p.Ser475Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 9.67028206568003 0.541992006917746 476.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ser475Asn Rv1129c_p.Ser475Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.9820231071276 0.168448731581911 252 4649 False False 0 0 1.9820231071276 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12235036001139 0.310791984491028 261 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ser475Gly Rv1129c_p.Ser475Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4398 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3678 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ser476Asn Rv1129c_p.Ser476Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.75142405620251 0.304356294847217 327.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ser476Gly Rv1129c_p.Ser476Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4411 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3690 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ser480Pro Rv1129c_p.Ser480Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 17 1 16 7 26 16803 30506 0.000416418798334324 0.000167437820935922 0.000857792460925722 0.999148434429451 0.998752506314373 0.99944365605196 0.212121212121212 0.0898042445427013 0.389080919674113 0.0588235294117647 0.00148817439126663 0.28688939666722 0.037037037037037 0.000937257091944708 0.189705617413044 0.113469320954591 0.00270976342130403 0.730511671812376 0.00943585136546967 101 4649 False False 0.488790921035163 0.179085225317654 1.15655172382726 5.9509640561771e-05 1.50665251795498e-06 0.000331521396580934 0.999148434429451 0.998752506314373 0.99944365605196 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 12 0 12 4 18 11498 23689 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 0.999240730585902 0.998800291409329 0.999549948712402 0.181818181818181 0.0518672993124368 0.402845783077871 0 0 0.264648469397051 0 0 0.185301968137852 0 0 0.741630187809233 0.0119696453310962 84 3890 False False 0 0 0 0 0 0 0 0.457838078119866 0.112678820467188 1.3903382040267 0 0 0.000320776462830572 0.999240730585902 0.998800291409329 0.999549948712402 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ser4Arg Rv1129c_p.Ser4Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ser4Gly Rv1129c_p.Ser4Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ser77Tyr Rv1129c_p.Ser77Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 7 16810 30525 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 1.26007067420399 0.0561478031672613 154 4649 False False 0 0 1.26007067420399 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 7 11502 23700 0 0 0.000320664925697395 0.999704728561184 0.999391723222185 0.999881277590374 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 1.42986888806462 0.104255162462523 134.5 3890 False False 0 0 0 0 0 0 0 0 0 1.42986888806462 0 0 0.000320664925697395 0.999704728561184 0.999391723222185 0.999881277590374 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ser78Leu Rv1129c_p.Ser78Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4278 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3578 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Ser89Ala Rv1129c_p.Ser89Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Thr12Met Rv1129c_p.Thr12Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 9 0 9 14 12 16796 30520 0.000832837596668649 0.000455392489979272 0.00139696554892221 0.999606969736669 0.999313555980458 0.999796899563454 0.538461538461538 0.333708218475292 0.734128782577048 0 0 0.336267116879942 0 0 0.264648469397051 0 0 0.920754292624931 0.031507580035126 134 4649 False False 2.1199491942526 0.90985544713252 5.01880847262685 0 0 0.000219604333908644 0.999606969736669 0.999313555980458 0.999796899563454 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 14 11 11488 23696 0.00121717962093548 0.000665598145642159 0.00204137811638842 0.999536002024718 0.999169931473241 0.999768351851939 0.56 0.349281633991335 0.755976334852791 0 0 0.369416647552819 0 0 0.284914152918154 0 0 1.20863619288537 0.0599680946686982 124 3890 False False 0 0 0 0 0 0 0 2.62522157508229 1.10673486427514 6.39187854251353 0 0 0.000321055645424387 0.999536002024718 0.999169931473241 0.999768351851939 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Thr131Ala Rv1129c_p.Thr131Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 3 16808 30529 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999901742434167 0.999712876815577 0.99997973646933 0.4 0.0527449505263169 0.853367200365326 0 0 0.975 0 0 0.707598226178713 0 0 70.7622624541429 1 1627.5 4649 False False 1.21089163890211 0.101157890363798 10.5697741171107 0 0 0.000219447565534303 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 3601 3890 False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 0 0 0.000320720684566658 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Thr131Ile Rv1129c_p.Thr131Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Thr131Pro Rv1129c_p.Thr131Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 1 7 54 8 16756 30524 0.0032123735871505 0.00241412734534404 0.00418939791764501 0.999737979824446 0.999483781433772 0.999886871715824 0.870967741935483 0.761491863618209 0.942609994392978 0.125 0.0031597235312519 0.526509670875206 0.111111111111111 0.00280913674659921 0.482496514917337 0.260239402516795 0.00577796458439553 2.02602895099633 0.273926074170861 287 4649 False False 12.2963117689185 5.81405404634715 29.9068551471519 5.96765530822939e-05 1.51087837072392e-06 0.000332451120290999 0.999737979824446 0.999483781433772 0.999886871715824 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 37 6 11465 23701 0.0032168318553295 0.00226592712135244 0.00443127959617942 0.9997469101953 0.999449212060655 0.99990711502044 0.860465116279069 0.72067519968585 0.947023426133182 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.75603279448617 0.18675976017273 201 3890 False False 0 0 0 0 0 0 0 12.748030236953 5.3311319729552 37.0015460165365 0 0 0.000321699613322993 0.9997469101953 0.999449212060655 0.99990711502044 5 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Thr142Asn Rv1129c_p.Thr142Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4351 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3640 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Thr145Ile Rv1129c_p.Thr145Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Thr16Lys Rv1129c_p.Thr16Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 9 0 9 0 9 16810 30523 0 0 0.000219421459229958 0.999705227302502 0.999440503684993 0.999865202576615 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.920078094923294 0.0314975203720328 131 4649 False False 0 0 0.920078094923294 0 0 0.000219421459229958 0.999705227302502 0.999440503684993 0.999865202576615 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 0 9 11502 23698 0 0 0.000320664925697395 0.999620365292951 0.999279457952852 0.99982639261309 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.336267116879942 0 0 1.04405446176545 0.0357327658391664 101.5 3890 False False 0 0 0 0 0 0 0 0 0 1.04405446176545 0 0 0.000320664925697395 0.999620365292951 0.999279457952852 0.99982639261309 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Thr187Asn Rv1129c_p.Thr187Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Thr187Ile Rv1129c_p.Thr187Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4352 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3641 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Thr215Ala Rv1129c_p.Thr215Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 70.7668929171829 1 1627.5 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 0 0 0.000219447565534303 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3662 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Thr224Ser Rv1129c_p.Thr224Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 4284 4649 False False 0 0 1.9820231071276 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 3584 3890 False False 0 0 0 0 0 0 0 0 0 2.24912710990902 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Thr261Pro Rv1129c_p.Thr261Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 14 11 16796 30521 0.000832837596668649 0.000455392489979272 0.00139696554892221 0.999639722258614 0.999355455254591 0.999820137367966 0.56 0.349281633991335 0.755976334852791 0 0 0.707598226178713 0 0 0.284914152918154 0 0 4.39806461791697 0.55691289783067 771 4649 False False 2.31274762389313 0.975118373095062 5.63074953061617 0 0 0.000219604333908644 0.999639722258614 0.999355455254591 0.999820137367966 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 14 11 11488 23696 0.00121717962093548 0.000665598145642159 0.00204137811638842 0.999536002024718 0.999169931473241 0.999768351851939 0.56 0.349281633991335 0.755976334852791 0 0 0.707598226178713 0 0 0.284914152918154 0 0 4.99264366534427 0.555678116920132 488 3890 False False 0 0 0 0 0 0 0 2.62522157508229 1.10673486427514 6.39187854251353 0 0 0.000321055645424387 0.999536002024718 0.999169931473241 0.999768351851939 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Thr267Ala Rv1129c_p.Thr267Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Thr2Ala Rv1129c_p.Thr2Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 1 6 16809 30526 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999803484868334 0.999572318737888 0.999927879105266 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.521823750104981 0 0 0.4592581264399 0 0 1.98207610360064 0.168450491331954 265 4649 False False 0.302675154183274 0.00658396461982027 2.49513982006856 0 0 0.000219434511605659 0.999803484868334 0.999572318737888 0.999927879105266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 1 6 11501 23701 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.9997469101953 0.999449212060655 0.99990711502044 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.521823750104981 0 0 0.4592581264399 0 0 2.24922795223804 0.18043046509787 187.5 3890 False False 0 0 0 0 0 0 0 0.343462887285163 0.00747035147172492 2.83150389371471 0 0 0.000320692802708327 0.9997469101953 0.999449212060655 0.99990711502044 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Thr2Met Rv1129c_p.Thr2Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 80.2910622977969 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 2 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Thr323Ala Rv1129c_p.Thr323Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 20 4 16790 30528 0.00118976799524092 0.000726887900057249 0.00183690503094944 0.999868989912223 0.999664596427238 0.999964303043777 0.833333333333333 0.626158286511317 0.952646373392742 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.75470187617292 0.304383117303191 369 4649 False False 9.09112567004169 3.04441035552351 36.569695967707 0 0 0.000219682802119661 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 8 3 11494 23704 0.000695531211963136 0.000300327312744212 0.00137001129783907 0.99987345509765 0.999630227076139 0.999973902638554 0.727272727272727 0.390257440427578 0.939782265827093 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.99172154655264 0.555676444976733 485.5 3890 False False 0 0 0 0 0 0 0 5.49944898787773 1.31956246574254 32.1907740650698 0 0 0.000320888077582845 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Thr430Pro Rv1129c_p.Thr430Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 4 2 16806 30530 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999934494956111 0.999763393503742 0.99999206693684 0.666666666666666 0.222778095503512 0.956728131707258 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.67289635744665 0.542027951562172 754 4649 False False 3.63322622872783 0.520625747830046 40.1764939558657 0 0 0.000219473678051534 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.9727417274169 1 1214.5 3890 False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 0 0 0.000320692802708327 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Thr439Ala Rv1129c_p.Thr439Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4412 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3691 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Thr44Ile Rv1129c_p.Thr44Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Thr453Met Rv1129c_p.Thr453Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4272 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Trp232Arg Rv1129c_p.Trp232Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4355 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Trp232Gly Rv1129c_p.Trp232Gly 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 29 16806 30503 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999050176863618 0.998636178123902 0.99936379914753 0.121212121212121 0.0340328814229786 0.28201622853722 NA NA NA 0 0 0.119444869069502 NA NA NA NA 4327 4649 False False 0.250345730383647 0.0639076684546368 0.713095595646224 0 0 0.000219473678051534 0.999050176863618 0.998636178123902 0.99936379914753 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 17 11500 23690 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999282912220019 0.998852120448669 0.999582216212894 0.105263157894736 0.0130121643717774 0.331376664456765 NA NA NA 0 0 0.195064322969093 NA NA NA NA 3621 3890 False False 0 0 0 0 0 0 0 0.24235294117647 0.0271662646620275 1.02125663054826 0 0 0.000320720684566658 0.999282912220019 0.998852120448669 0.999582216212894 4 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Trp366Cys Rv1129c_p.Trp366Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4420 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Trp366Gly Rv1129c_p.Trp366Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4380 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Tyr137Asn Rv1129c_p.Tyr137Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4285 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3585 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Tyr137Asp Rv1129c_p.Tyr137Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 6 7 16804 30525 0.000356930398572278 0.000130998068917797 0.000776724091447791 0.99977073234639 0.999527678427408 0.999907817703152 0.461538461538461 0.192232441801288 0.748654517729696 0 0 0.707598226178713 0 0 0.409616397225003 0 0 4.3965464422827 0.556922836541859 778 4649 False False 1.55702723841262 0.43221622692255 5.41149478110221 0 0 0.000219499796783869 0.99977073234639 0.999527678427408 0.999907817703152 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 4 5 11498 23702 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 0.999789091829417 0.999507879904061 0.999931515258336 0.444444444444444 0.136995662265166 0.787991493221131 0 0 0.841886116991581 0 0 0.521823750104981 0 0 10.9742132005842 1 1214.5 3890 False False 0 0 0 0 0 0 0 1.64912158636284 0.327175514256965 7.66332787722062 0 0 0.000320776462830572 0.999789091829417 0.999507879904061 0.999931515258336 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Tyr137Cys Rv1129c_p.Tyr137Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 3 16808 30529 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999901742434167 0.999712876815577 0.99997973646933 0.4 0.0527449505263169 0.853367200365326 0 0 0.975 0 0 0.707598226178713 0 0 70.7622624541429 1 1627.5 4649 False False 1.21089163890211 0.101157890363798 10.5697741171107 0 0 0.000219447565534303 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 80.2773259044493 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Tyr137His Rv1129c_p.Tyr137His 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 16809 30529 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999901742434167 0.999712876815577 0.99997973646933 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.39581433818102 0.556927644280045 795 4649 False False 0.605409800305391 0.0115361654751757 7.54087213596152 0 0 0.000219434511605659 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 3 11501 23704 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.99987345509765 0.999630227076139 0.999973902638554 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98868218084989 0.555670981350655 466 3890 False False 0 0 0 0 0 0 0 0.687012723531287 0.0130900577164196 8.55773267307823 0 0 0.000320692802708327 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Tyr137Ser Rv1129c_p.Tyr137Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4306 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Tyr301His Rv1129c_p.Tyr301His 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.67117271135833 0.542004252564565 721 4649 False False 0.908144446427509 0.0153974005043644 17.4461131425891 0 0 0.000219434511605659 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.9727417274169 1 1214.5 3890 False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 0 0 0.000320692802708327 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Tyr462Cys Rv1129c_p.Tyr462Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 4 16809 30528 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999868989912223 0.999664596427238 0.999964303043777 0.2 0.00505076337946806 0.716417936118089 0 0 0.707598226178713 0 0 0.602364635616474 0 0 4.39567032383538 0.556928590311153 805 4649 False False 0.454042477244333 0.00922341562850508 4.58878013974823 0 0 0.000219434511605659 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 1 4 11501 23703 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999831273463534 0.999568049920357 0.99995402584539 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12262191820896 0.310798846422045 285 3890 False False 0 0 0 0 0 0 0 0.515237805408225 0.0104655802548345 5.20753049950472 0 0 0.000320692802708327 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Tyr462His Rv1129c_p.Tyr462His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4434 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Tyr462Leu Rv1129c_p.Tyr462Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Val101Ile Rv1129c_p.Val101Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4421 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3699 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Val110Phe Rv1129c_p.Val110Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4381 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3663 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Val116Phe Rv1129c_p.Val116Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 1 16807 30531 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999967247478055 0.999817528289014 0.999999170778282 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 70.771098821806 1 1627.5 4649 False False 5.44969358005592 0.437509494081317 285.652299683162 0 0 0.000219460621016169 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3597 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Val121Leu Rv1129c_p.Val121Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Val226Leu Rv1129c_p.Val226Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3622 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Val249Leu Rv1129c_p.Val249Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Val259Ala Rv1129c_p.Val259Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 3 6 16807 30526 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999803484868334 0.999572318737888 0.999927879105266 0.333333333333333 0.0748546314196918 0.700704943791459 0 0 0.521823750104981 0 0 0.4592581264399 0 0 1.98231198657631 0.168458330311832 277 4649 False False 0.908133515796989 0.146921475063029 4.25286483046122 0 0 0.000219460621016169 0.999803484868334 0.999572318737888 0.999927879105266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 1 4 11501 23703 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999831273463534 0.999568049920357 0.99995402584539 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12262191820896 0.310798846422045 285 3890 False False 0 0 0 0 0 0 0 0.515237805408225 0.0104655802548345 5.20753049950472 0 0 0.000320692802708327 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Val259Met Rv1129c_p.Val259Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Val272Ile Rv1129c_p.Val272Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Val317Ala Rv1129c_p.Val317Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Val337Ala Rv1129c_p.Val337Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 6 3 16804 30529 0.000356930398572278 0.000130998068917797 0.000776724091447791 0.999901742434167 0.999712876815577 0.99997973646933 0.666666666666666 0.29929505620854 0.925145368580308 0 0 0.975 0 0 0.707598226178713 0 0 70.7790879730247 1 1627.5 4649 False False 3.63353963342061 0.775880513842457 22.4552956007886 0 0 0.000219499796783869 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 5 1 11497 23706 0.00043470700747696 0.000141162766530747 0.00101416710312943 0.999957818365883 0.999765001636458 0.999998932054057 0.833333333333333 0.358765421002325 0.99578925548551 0 0 0.975 0 0 0.975 0 0 80.3189618536173 1 1214.5 3890 False False 0 0 0 0 0 0 0 10.3096459946072 1.15337945963023 486.419600220716 0 0 0.000320804359238686 0.999957818365883 0.999765001636458 0.999998932054057 5 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Val337Leu Rv1129c_p.Val337Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 16810 30526 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.54251408011679 0.0957784996510068 197 4649 False False 0 0 1.54251408011679 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 11502 23701 0 0 0.000320664925697395 0.9997469101953 0.999449212060655 0.99990711502044 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.75038628279554 0.186840354932931 214 3890 False False 0 0 0 0 0 0 0 0 0 1.75038628279554 0 0 0.000320664925697395 0.9997469101953 0.999449212060655 0.99990711502044 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Val337Phe Rv1129c_p.Val337Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4413 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3692 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Val34Leu Rv1129c_p.Val34Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.9820231071276 0.168448731581911 252 4649 False False 0 0 1.9820231071276 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Val359Ile Rv1129c_p.Val359Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Val359Leu Rv1129c_p.Val359Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4273 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3574 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Val394Met Rv1129c_p.Val394Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 70.7668929171829 1 1627.5 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 0 0 0.000219447565534303 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 80.2980353694986 1 1214.5 3890 False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 0 0 0.000320720684566658 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Val414Ile Rv1129c_p.Val414Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Val486Ala Rv1129c_p.Val486Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Val486Phe Rv1129c_p.Val486Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4405 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3684 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Val59Ala Rv1129c_p.Val59Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 70.7668929171829 1 1627.5 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 0 0 0.000219447565534303 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 80.2980353694986 1 1214.5 3890 False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 0 0 0.000320720684566658 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Val59Met Rv1129c_p.Val59Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 80.2910622977969 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Val6Ile Rv1129c_p.Val6Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 9 0 9 6 9 16804 30523 0.000356930398572278 0.000130998068917797 0.000776724091447791 0.999705227302502 0.999440503684993 0.999865202576615 0.4 0.163364323859513 0.677130233793718 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.920406506792643 0.031502385853414 133 4649 False False 1.21094183924462 0.354642867254006 3.81017457324888 0 0 0.000219499796783869 0.999705227302502 0.999440503684993 0.999865202576615 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 5 3 11497 23704 0.00043470700747696 0.000141162766530747 0.00101416710312943 0.99987345509765 0.999630227076139 0.999973902638554 0.625 0.244863216366551 0.914766585862746 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.99041850782513 0.555674089716787 481.5 3890 False False 0 0 0 0 0 0 0 3.43625873416253 0.668393407932569 22.1300557847574 0 0 0.000320804359238686 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Val85Leu Rv1129c_p.Val85Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Val85Met Rv1129c_p.Val85Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4409 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3688 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Val97Ala Rv1129c_p.Val97Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Val97Ile Rv1129c_p.Val97Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4428 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Val9fs Rv1129c_p.Val9fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4436 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3709 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv1129c p.Val9Met Rv1129c_p.Val9Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4292 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3590 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c c.1002C>T Rv2477c_c.1002C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1008G>A Rv2477c_c.1008G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1014G>A Rv2477c_c.1014G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1030T>C Rv2477c_c.1030T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1035C>T Rv2477c_c.1035C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 1 16807 30531 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999967247478055 0.999817528289014 0.999999170778282 0.75 0.194120449683243 0.99369053679029 NA NA NA NA NA NA NA NA NA NA NA NA False False 5.44969358005592 0.437509494081317 285.652299683162 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 1 11499 23706 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.999957818365883 0.999765001636458 0.999998932054057 0.75 0.194120449683243 0.99369053679029 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 6.18471171406209 0.496496186771195 324.103527365594 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1038C>T Rv2477c_c.1038C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1065C>T Rv2477c_c.1065C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1068C>T Rv2477c_c.1068C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 5 16809 30527 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999836237390279 0.999617874429585 0.999946824656822 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.363222083407698 0.00768325476784986 3.24674897733262 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1071G>T Rv2477c_c.1071G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1086A>G Rv2477c_c.1086A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 30 4 16780 30528 0.00178465199286139 0.00120441111287972 0.00254672951354614 0.999868989912223 0.999664596427238 0.999964303043777 0.88235294117647 0.725496512857644 0.96699831966353 NA NA NA NA NA NA NA NA NA NA NA NA False False 13.6448152562574 4.8062498898419 53.3529430284636 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 30 4 11472 23703 0.00260824204486176 0.00176044063976377 0.00372135102988799 0.999831273463534 0.999568049920357 0.99995402584539 0.88235294117647 0.725496512857644 0.96699831966353 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 15.4962081589958 5.45898059301302 60.5603855498919 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1098C>G Rv2477c_c.1098C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1101C>T Rv2477c_c.1101C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.6329128986197 0.189104318453829 214.057761575796 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1104C>T Rv2477c_c.1104C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 5 0 16805 30532 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 1 0.999879187193184 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.66460481015123 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1110C>T Rv2477c_c.1110C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1116A>G Rv2477c_c.1116A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 5 134 16805 30398 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 0.995611162059478 0.994804128966403 0.99632151798031 0.0359712230215827 0.0117811206243228 0.081946981150088 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.0674950152539889 0.0215669183498604 0.161521083569805 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 4 126 11498 23581 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 0.99468511410132 0.993675159953325 0.995570683849767 0.0307692307692307 0.00844596436857444 0.0769073167010305 NA NA NA NA NA NA NA NA NA NA NA NA False True 1 1 1 0 0 0 0 0.0651072512265763 0.0174538724202723 0.170920874135648 NA NA NA NA NA NA 7 5) Not assoc w R Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1122C>T Rv2477c_c.1122C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1134C>G Rv2477c_c.1134C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.114C>T Rv2477c_c.114C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1152C>A Rv2477c_c.1152C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1152C>G Rv2477c_c.1152C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1152C>T Rv2477c_c.1152C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1155G>A Rv2477c_c.1155G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1158G>A Rv2477c_c.1158G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1164C>T Rv2477c_c.1164C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.750576632084797 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1167G>A Rv2477c_c.1167G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1167G>T Rv2477c_c.1167G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1170C>T Rv2477c_c.1170C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1176C>T Rv2477c_c.1176C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1203C>T Rv2477c_c.1203C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.120C>T Rv2477c_c.120C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1212G>A Rv2477c_c.1212G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1215T>C Rv2477c_c.1215T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1218C>A Rv2477c_c.1218C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1221G>A Rv2477c_c.1221G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.123G>T Rv2477c_c.123G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1269G>A Rv2477c_c.1269G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.126C>T Rv2477c_c.126C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1278G>A Rv2477c_c.1278G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1323T>C Rv2477c_c.1323T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1335C>T Rv2477c_c.1335C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1344C>T Rv2477c_c.1344C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1383C>A Rv2477c_c.1383C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1387C>T Rv2477c_c.1387C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1413C>T Rv2477c_c.1413C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.141C>A Rv2477c_c.141C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1422T>C Rv2477c_c.1422T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1434G>C Rv2477c_c.1434G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1443G>C Rv2477c_c.1443G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1455G>A Rv2477c_c.1455G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1473C>T Rv2477c_c.1473C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1476C>T Rv2477c_c.1476C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1491C>T Rv2477c_c.1491C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1494T>C Rv2477c_c.1494T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1497C>T Rv2477c_c.1497C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1509C>T Rv2477c_c.1509C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.150C>T Rv2477c_c.150C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1512C>T Rv2477c_c.1512C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1515G>A Rv2477c_c.1515G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1518C>T Rv2477c_c.1518C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1521G>A Rv2477c_c.1521G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1521G>T Rv2477c_c.1521G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1533G>A Rv2477c_c.1533G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1542T>C Rv2477c_c.1542T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1545C>T Rv2477c_c.1545C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1018 4366 15792 26166 0.0605591909577632 0.0570000240374614 0.0642713176743229 0.857002489191667 0.853025473578754 0.860911449520155 0.189078751857355 0.178697160973527 0.199798459541627 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.386335172171811 0.359471702933128 0.414882185334216 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 683 3590 10819 20117 0.0593809772213528 0.055130371834174 0.0638562502054139 0.848567933521744 0.843941025467626 0.853109215053395 0.159840861221624 0.14897147761098 0.171177373700247 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 0 0.353754807195944 0.324424426453328 0.385322795755965 NA NA NA NA NA NA 670 5) Not assoc w R Now listed Silent mutation no 0 +Rifampicin Rv2477c c.156C>G Rv2477c_c.156C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1581C>G Rv2477c_c.1581C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1581C>T Rv2477c_c.1581C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1587C>T Rv2477c_c.1587C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1596C>T Rv2477c_c.1596C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1605C>T Rv2477c_c.1605C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 8 16810 30524 0 0 0.000219421459229958 0.999737979824446 0.999483781433772 0.999886871715824 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.06393155676265 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 6 11502 23701 0 0 0.000320664925697395 0.9997469101953 0.999449212060655 0.99990711502044 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.75038628279554 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1620C>A Rv2477c_c.1620C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1620C>T Rv2477c_c.1620C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1626C>T Rv2477c_c.1626C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1629C>T Rv2477c_c.1629C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1635T>A Rv2477c_c.1635T>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1638A>G Rv2477c_c.1638A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1659C>T Rv2477c_c.1659C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.165C>T Rv2477c_c.165C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 8 2 16802 30530 0.000475907198096371 0.00020548462525215 0.000937510381255989 0.999934494956111 0.999763393503742 0.99999206693684 0.8 0.443904537692358 0.974789273673166 NA NA NA NA NA NA NA NA NA NA NA NA False False 7.26818235924294 1.45017637426587 70.3957327614674 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 8 2 11494 23705 0.000695531211963136 0.000300327312744212 0.00137001129783907 0.999915636731767 0.999695284447545 0.999989783053538 0.8 0.443904537692358 0.974789273673166 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 8.24952148947276 1.64581870314284 79.7086041198813 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1663C>T Rv2477c_c.1663C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1665G>T Rv2477c_c.1665G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.1674C>T Rv2477c_c.1674C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.-17_-16insT Rv2477c_c.-17_-16insT 2 upstream_gene_variant 2784058 1 12 0 12 0 12 16810 30520 0 0 0.000219421459229958 0.999606969736669 0.999313555980458 0.999796899563454 0 0 0.264648469397051 0 0 0.264648469397051 0 0 0.264648469397051 0 0 0.653527260731835 0.00613809319768167 91 4649 False False 0 0 0.653527260731835 0 0 0.000219421459229958 0.999606969736669 0.999313555980458 0.999796899563454 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 12 0 12 0 12 11502 23695 0 0 0.000320664925697395 0.999493820390602 0.999115973206486 0.999738423129043 0 0 0.264648469397051 0 0 0.264648469397051 0 0 0.264648469397051 0 0 0.741560034978285 0.011968057929515 83 3890 False False 0 0 0 0 0 0 0 0 0 0.741560034978285 0 0 0.000320664925697395 0.999493820390602 0.999115973206486 0.999738423129043 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c c.189C>T Rv2477c_c.189C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.-1927_-28del Rv2477c_c.-1927_-28del 2 upstream_gene_variant 2784069 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4483 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3745 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c c.-1927_-66del Rv2477c_c.-1927_-66del 2 upstream_gene_variant 2784107 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c c.201C>A Rv2477c_c.201C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.204C>T Rv2477c_c.204C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.-20C>G Rv2477c_c.-20C>G 2 upstream_gene_variant 2784062 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c c.219G>A Rv2477c_c.219G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.-23G>A Rv2477c_c.-23G>A 2 upstream_gene_variant 2784065 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c c.252C>T Rv2477c_c.252C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.-25A>C Rv2477c_c.-25A>C 2 upstream_gene_variant 2784067 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4473 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3738 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c c.270A>G Rv2477c_c.270A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.341150751115529 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.-28C>T Rv2477c_c.-28C>T 2 upstream_gene_variant 2784070 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c c.-29C>T Rv2477c_c.-29C>T 2 upstream_gene_variant 2784071 1 2 0 2 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 9.67028206568003 0.541992006917746 476.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 10.9713274274722 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c c.303C>T Rv2477c_c.303C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.309C>T Rv2477c_c.309C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 6 16809 30526 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999803484868334 0.999572318737888 0.999927879105266 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.302675154183274 0.00658396461982027 2.49513982006856 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 3 11501 23704 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.99987345509765 0.999630227076139 0.999973902638554 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.687012723531287 0.0130900577164196 8.55773267307823 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.312C>T Rv2477c_c.312C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 5 16806 30527 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999836237390279 0.999617874429585 0.999946824656822 0.444444444444444 0.136995662265166 0.787991493221131 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.45314768535047 0.288302513248679 6.7527137819275 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 4 5 11498 23702 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 0.999789091829417 0.999507879904061 0.999931515258336 0.444444444444444 0.136995662265166 0.787991493221131 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.64912158636284 0.327175514256965 7.66332787722062 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.318C>T Rv2477c_c.318C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 19 16808 30513 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.99937770208306 0.999028374542228 0.999625295739155 0.0952380952380952 0.0117493178844458 0.303774406913924 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.191093213757859 0.0215819726593938 0.792263260885684 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 17 11500 23690 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999282912220019 0.998852120448669 0.999582216212894 0.105263157894736 0.0130121643717774 0.331376664456765 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.24235294117647 0.0271662646620275 1.02125663054826 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.-31A>G Rv2477c_c.-31A>G 2 upstream_gene_variant 2784073 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c c.333C>T Rv2477c_c.333C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.-34G>A Rv2477c_c.-34G>A 2 upstream_gene_variant 2784076 NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4524 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3783 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c c.352C>T Rv2477c_c.352C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.387G>A Rv2477c_c.387G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.393C>T Rv2477c_c.393C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 22 16806 30510 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999279444517227 0.998909272375137 0.999548378362908 0.153846153846153 0.0435634765389238 0.348678785535361 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.330076920580312 0.0826999724521732 0.972089303633469 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 21 11499 23686 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.999114185683553 0.998646255755329 0.99945158598871 0.125 0.0265593149862489 0.323611358188833 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.294261612811051 0.0561956957588794 0.985824838233844 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.396C>T Rv2477c_c.396C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.399C>T Rv2477c_c.399C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.417G>A Rv2477c_c.417G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.-41T>C Rv2477c_c.-41T>C 2 upstream_gene_variant 2784083 NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4455 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c c.429G>A Rv2477c_c.429G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.-43G>A Rv2477c_c.-43G>A 2 upstream_gene_variant 2784085 NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4456 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3725 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c c.-44G>A Rv2477c_c.-44G>A 2 upstream_gene_variant 2784086 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4531 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c c.453G>A Rv2477c_c.453G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.45C>T Rv2477c_c.45C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.468G>A Rv2477c_c.468G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.483C>T Rv2477c_c.483C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.750576632084797 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.489C>T Rv2477c_c.489C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.48C>T Rv2477c_c.48C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.492G>A Rv2477c_c.492G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.499C>A Rv2477c_c.499C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.-4C>A Rv2477c_c.-4C>A 2 upstream_gene_variant 2784046 NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4514 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3773 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c c.-4C>T Rv2477c_c.-4C>T 2 upstream_gene_variant 2784046 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c c.51T>C Rv2477c_c.51T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 1 16807 30531 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999967247478055 0.999817528289014 0.999999170778282 0.75 0.194120449683243 0.99369053679029 NA NA NA NA NA NA NA NA NA NA NA NA False False 5.44969358005592 0.437509494081317 285.652299683162 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 1 11499 23706 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.999957818365883 0.999765001636458 0.999998932054057 0.75 0.194120449683243 0.99369053679029 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 6.18471171406209 0.496496186771195 324.103527365594 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.523T>C Rv2477c_c.523T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.528C>T Rv2477c_c.528C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.538C>T Rv2477c_c.538C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.540G>A Rv2477c_c.540G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.541T>C Rv2477c_c.541T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 32 7 16778 30525 0.00190362879238548 0.0013024338261299 0.00268630258659741 0.99977073234639 0.999527678427408 0.999907817703152 0.82051282051282 0.664650438873069 0.924649522683347 NA NA NA NA NA NA NA NA NA NA NA NA False False 8.31701377654411 3.60470277017785 22.3270576372087 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 27 6 11475 23701 0.00234741784037558 0.0015475155067352 0.00341354562468017 0.9997469101953 0.999449212060655 0.99990711502044 0.818181818181818 0.645399440549731 0.93021211633369 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 9.29450980392156 3.7572195100146 27.5275584857054 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.546G>A Rv2477c_c.546G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.549C>A Rv2477c_c.549C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.-54T>C Rv2477c_c.-54T>C 2 upstream_gene_variant 2784096 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c c.558G>A Rv2477c_c.558G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.-57C>T Rv2477c_c.-57C>T 2 upstream_gene_variant 2784099 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c c.585G>A Rv2477c_c.585G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.588G>A Rv2477c_c.588G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.612C>T Rv2477c_c.612C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.615C>T Rv2477c_c.615C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.618C>T Rv2477c_c.618C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 8 16810 30524 0 0 0.000219421459229958 0.999737979824446 0.999483781433772 0.999886871715824 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.06393155676265 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 8 11502 23699 0 0 0.000320664925697395 0.999662546927068 0.999335191784523 0.999854300817065 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.20731769892417 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.627C>T Rv2477c_c.627C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.630G>C Rv2477c_c.630G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.639C>T Rv2477c_c.639C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.660C>T Rv2477c_c.660C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.696C>T Rv2477c_c.696C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.699C>T Rv2477c_c.699C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.69C>T Rv2477c_c.69C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.702C>A Rv2477c_c.702C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.705C>T Rv2477c_c.705C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.708C>A Rv2477c_c.708C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.708C>T Rv2477c_c.708C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.9820231071276 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.24912710990902 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.-71C>T Rv2477c_c.-71C>T 2 upstream_gene_variant 2784113 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c c.723C>T Rv2477c_c.723C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.9820231071276 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.24912710990902 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.729C>G Rv2477c_c.729C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.733C>T Rv2477c_c.733C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.-73C>G Rv2477c_c.-73C>G 2 upstream_gene_variant 2784115 1 1 0 1 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 70.7668929171829 1 1627.5 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 0 0 0.000219447565534303 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3768 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c c.753G>A Rv2477c_c.753G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.908144446427509 0.0153974005043644 17.4461131425891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.75G>T Rv2477c_c.75G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.762G>A Rv2477c_c.762G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.-76C>G Rv2477c_c.-76C>G 2 upstream_gene_variant 2784118 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c c.-77T>C Rv2477c_c.-77T>C 2 upstream_gene_variant 2784119 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c c.-78delG Rv2477c_c.-78delG 2 upstream_gene_variant 2784119 1 2 0 2 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.67117271135833 0.542004252564565 721 4649 False False 0.908144446427509 0.0153974005043644 17.4461131425891 0 0 0.000219434511605659 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c c.-7C>T Rv2477c_c.-7C>T 2 upstream_gene_variant 2784049 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4515 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3774 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c c.801C>T Rv2477c_c.801C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.813T>G Rv2477c_c.813T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.-81G>A Rv2477c_c.-81G>A 2 upstream_gene_variant 2784123 1 14 0 14 1 24 16809 30508 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999213939473339 0.99883062854842 0.999496293299407 0.04 0.00101219969931084 0.203516913922414 0 0 0.231635761650116 0 0 0.142473597722525 0 0 0.547266481249256 0.00341828386251702 79 4649 False False 0.075624169591687 0.00184305732332829 0.463844663460951 0 0 0.000219434511605659 0.999213939473339 0.99883062854842 0.999496293299407 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 0 18 11502 23689 0 0 0.000320664925697395 0.999240730585902 0.998800291409329 0.999549948712402 0 0 0.185301968137852 0 0 0.336267116879942 0 0 0.185301968137852 0 0 1.04365799166773 0.0357126274552753 99 3890 False False 0 0 0 0 0 0 0 0 0 0.468558999031164 0 0 0.000320664925697395 0.999240730585902 0.998800291409329 0.999549948712402 4 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c c.81T>C Rv2477c_c.81T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.1990579265185 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.828G>A Rv2477c_c.828G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.-82A>G Rv2477c_c.-82A>G 2 upstream_gene_variant 2784124 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c c.831C>G Rv2477c_c.831C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.831C>T Rv2477c_c.831C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 6 16809 30526 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999803484868334 0.999572318737888 0.999927879105266 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.302675154183274 0.00658396461982027 2.49513982006856 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 5 11501 23702 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999789091829417 0.999507879904061 0.999931515258336 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.412172854534388 0.00871781959321125 3.68423590106777 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.846C>G Rv2477c_c.846C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.-86G>A Rv2477c_c.-86G>A 2 upstream_gene_variant 2784128 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c c.870C>T Rv2477c_c.870C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.873C>T Rv2477c_c.873C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.879G>A Rv2477c_c.879G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.885A>C Rv2477c_c.885A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.-88C>T Rv2477c_c.-88C>T 2 upstream_gene_variant 2784130 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4437 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3710 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c c.894G>C Rv2477c_c.894G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.-8A>G Rv2477c_c.-8A>G 2 upstream_gene_variant 2784050 1 6 1 5 6 27 16804 30505 0.000356930398572278 0.000130998068917797 0.000776724091447791 0.999115681907506 0.998713622442022 0.999417150456935 0.181818181818181 0.06978788366631 0.354600559450268 0.166666666666666 0.00421074451448947 0.641234578997674 0.0357142857142857 0.000903798755658059 0.183477597544623 0.363068317067364 0.00768000409830503 3.24537638370776 0.432563906109034 440 4649 False False 0.403409241185961 0.136143625004298 0.997678094829706 5.95060993751859e-05 1.50656286300806e-06 0.000331501671719057 0.999115681907506 0.998713622442022 0.999417150456935 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 1 4 5 20 11497 23687 0.00043470700747696 0.000141162766530747 0.00101416710312943 0.99915636731767 0.998697376967606 0.99948461349205 0.2 0.068311464012484 0.407037432278677 0.2 0.00505076337946806 0.716417936118089 0.0476190476190476 0.00120488344836351 0.238159909936821 0.515069148473514 0.0104621557796917 5.20582608875526 1 1214.5 3890 False False 0 0 0 0 0 0 0 0.515069148473514 0.151017802887557 1.41477022717033 8.69716472429987e-05 2.20192904072632e-06 0.000484478680214183 0.99915636731767 0.998697376967606 0.99948461349205 3 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c c.900G>A Rv2477c_c.900G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.90G>A Rv2477c_c.90G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.912C>G Rv2477c_c.912C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.918C>T Rv2477c_c.918C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.908144446427509 0.0153974005043644 17.4461131425891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.933C>T Rv2477c_c.933C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.948C>G Rv2477c_c.948C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 19 83 16791 30449 0.00113027959547888 0.000680635004098699 0.00176451134196716 0.997281540678632 0.99663115887173 0.997834198362528 0.186274509803921 0.116036656606601 0.275506041462224 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.415118397477707 0.23794958035712 0.689879483465782 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 6 50 11496 23657 0.000521648408972352 0.000191459062774625 0.00113506056981396 0.997890918294174 0.997220372511225 0.998434206102271 0.107142857142857 0.0403479461908222 0.218756471845279 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 0 0.246941544885177 0.0864980193741297 0.576467137733211 NA NA NA NA NA NA 4 5) Not assoc w R Now listed Silent mutation no 0 +Rifampicin Rv2477c c.948C>T Rv2477c_c.948C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.951A>G Rv2477c_c.951A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.954C>A Rv2477c_c.954C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.960G>C Rv2477c_c.960G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.96C>A Rv2477c_c.96C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.96C>T Rv2477c_c.96C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.978C>T Rv2477c_c.978C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c c.9G>A Rv2477c_c.9G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 12 16810 30520 0 0 0.000219421459229958 0.999606969736669 0.999313555980458 0.999796899563454 0 0 0.264648469397051 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.653527260731835 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 7 11502 23700 0 0 0.000320664925697395 0.999704728561184 0.999391723222185 0.999881277590374 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.42986888806462 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2477c LoF Rv2477c_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4649 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3890 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ala134Val Rv2477c_p.Ala134Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ala139Thr Rv2477c_p.Ala139Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ala139Val Rv2477c_p.Ala139Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ala223Val Rv2477c_p.Ala223Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4520 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3779 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ala234Thr Rv2477c_p.Ala234Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ala260Arg Rv2477c_p.Ala260Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4516 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3775 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ala260Val Rv2477c_p.Ala260Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ala271Gly Rv2477c_p.Ala271Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4521 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3780 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ala277Thr Rv2477c_p.Ala277Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4554 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3808 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ala277Val Rv2477c_p.Ala277Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4563 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3816 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ala286Ser Rv2477c_p.Ala286Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4532 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3789 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ala295Val Rv2477c_p.Ala295Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ala2Val Rv2477c_p.Ala2Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4517 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3776 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 2 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ala335Thr Rv2477c_p.Ala335Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ala392Thr Rv2477c_p.Ala392Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4479 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ala392Val Rv2477c_p.Ala392Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.67117271135833 0.542004252564565 721 4649 False False 0.908144446427509 0.0153974005043644 17.4461131425891 0 0 0.000219434511605659 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.9727417274169 1 1214.5 3890 False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 0 0 0.000320692802708327 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ala394Val Rv2477c_p.Ala394Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4525 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3784 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ala424Val Rv2477c_p.Ala424Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 1 7 16809 30525 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.99977073234639 0.999527678427408 0.999907817703152 0.125 0.0031597235312519 0.526509670875206 0 0 0.602364635616474 0 0 0.409616397225003 0 0 2.75131736360018 0.304355430202051 301 4649 False False 0.2594273475944 0.00575995110596449 2.01970184240593 0 0 0.000219434511605659 0.99977073234639 0.999527678427408 0.999907817703152 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 80.2773259044493 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ala428Thr Rv2477c_p.Ala428Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4526 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3785 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 2 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ala428Val Rv2477c_p.Ala428Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4487 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3749 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ala440Thr Rv2477c_p.Ala440Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ala454Glu Rv2477c_p.Ala454Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ala454Val Rv2477c_p.Ala454Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4438 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3711 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ala492Asp Rv2477c_p.Ala492Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4497 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ala520Val Rv2477c_p.Ala520Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4490 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3752 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ala52Thr Rv2477c_p.Ala52Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4474 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ala531Pro Rv2477c_p.Ala531Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4542 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3798 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ala531Thr Rv2477c_p.Ala531Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4527 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3786 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ala545Val Rv2477c_p.Ala545Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ala62Thr Rv2477c_p.Ala62Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ala65Val Rv2477c_p.Ala65Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 4 1 16806 30531 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999967247478055 0.999817528289014 0.999999170778282 0.8 0.28358206388191 0.994949236620532 NA NA NA 0 0 0.975 NA NA NA NA 4480 4649 False False 7.26669046769011 0.71899465830523 357.208630433948 0 0 0.000219473678051534 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 4 1 11498 23706 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 0.999957818365883 0.999765001636458 0.999998932054057 0.8 0.28358206388191 0.994949236620532 NA NA NA 0 0 0.975 NA NA NA NA 3743 3890 False False 0 0 0 0 0 0 0 8.24699947817011 0.815939832795188 405.284913246419 0 0 0.000320776462830572 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ala68Thr Rv2477c_p.Ala68Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ala68Val Rv2477c_p.Ala68Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 1 4 16809 30528 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999868989912223 0.999664596427238 0.999964303043777 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.75158776187525 0.30435761959971 350.5 4649 False False 0.454042477244333 0.00922341562850508 4.58878013974823 0 0 0.000219434511605659 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 1 4 11501 23703 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999831273463534 0.999568049920357 0.99995402584539 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12262191820896 0.310798846422045 285 3890 False False 0 0 0 0 0 0 0 0.515237805408225 0.0104655802548345 5.20753049950472 0 0 0.000320692802708327 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Arg231Cys Rv2477c_p.Arg231Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Arg231Leu Rv2477c_p.Arg231Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4462 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3729 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Arg233Cys Rv2477c_p.Arg233Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Arg251Pro Rv2477c_p.Arg251Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4549 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3803 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Arg257Ser Rv2477c_p.Arg257Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Arg265Gln Rv2477c_p.Arg265Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4450 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3721 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Arg274Gln Rv2477c_p.Arg274Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4555 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3809 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Arg302His Rv2477c_p.Arg302His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Arg316His Rv2477c_p.Arg316His 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Arg316Ser Rv2477c_p.Arg316Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4451 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3722 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Arg346Cys Rv2477c_p.Arg346Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 1 18 16809 30514 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999410454605004 0.999068423526975 0.999650561796013 0.0526315789473684 0.00133162880417942 0.260280654195214 0 0 0.521823750104981 0 0 0.185301968137852 0 0 1.98129696977854 0.168424631575179 228 4649 False False 0.10085205676853 0.00242455853002503 0.638882454972025 0 0 0.000219434511605659 0.999410454605004 0.999068423526975 0.999650561796013 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 1 17 11501 23690 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999282912220019 0.998852120448669 0.999582216212894 0.0555555555555555 0.00140555616736942 0.272943599673368 0 0 0.521823750104981 0 0 0.195064322969093 0 0 2.248182515166 0.180373504850706 161 3890 False False 0 0 0 0 0 0 0 0.121165934420024 0.00290305390139272 0.77349141370224 0 0 0.000320692802708327 0.999282912220019 0.998852120448669 0.999582216212894 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Arg399Leu Rv2477c_p.Arg399Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4538 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3795 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Arg448His Rv2477c_p.Arg448His 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Arg450Lys Rv2477c_p.Arg450Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4445 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3717 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Arg450Ser Rv2477c_p.Arg450Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4463 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3730 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Arg450Thr Rv2477c_p.Arg450Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 12 1 16798 30531 0.000713860797144556 0.000368914962606047 0.00124663876852724 0.999967247478055 0.999817528289014 0.999999170778282 0.923076923076923 0.639702564732122 0.998054371502653 0 0 0.975 0 0 0.975 0 0 70.8089744727958 1 1627.5 4649 False False 21.8104536254316 3.22631137889576 928.24059648621 0 0 0.000219578190293692 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 10 1 11492 23706 0.000869414014953921 0.000416994043678715 0.001598300185227 0.999957818365883 0.999765001636458 0.999998932054057 0.909090909090909 0.587220083011617 0.997701027786185 0 0 0.975 0 0 0.975 0 0 80.3538635761453 1 1214.5 3890 False False 0 0 0 0 0 0 0 20.6282631395753 2.93373003427251 891.367911239421 0 0 0.000320943914091465 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Arg499Cys Rv2477c_p.Arg499Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4564 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3817 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Arg504Cys Rv2477c_p.Arg504Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 70.7538526941519 1 1627.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Arg539Pro Rv2477c_p.Arg539Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4560 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3813 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Arg539Trp Rv2477c_p.Arg539Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Arg549Thr Rv2477c_p.Arg549Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4534 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3791 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Arg553His Rv2477c_p.Arg553His 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Arg557Cys Rv2477c_p.Arg557Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Arg86Cys Rv2477c_p.Arg86Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4484 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3746 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Arg86His Rv2477c_p.Arg86His 2 missense_variant (see "Genomic_coordinates" sheet) 1 54 1 53 10 68 16800 30464 0.000594883997620464 0.000285305684944214 0.00109373983334496 0.997772828507795 0.99717737154042 0.998270111848726 0.128205128205128 0.0632277341214986 0.223162146745246 0.0185185185185185 0.00046873840381796 0.0989151595078512 0.0144927536231884 0.000366857444740834 0.0781235357401634 0.0342138364779874 0.000854772106105825 0.199102263877346 3.15500876542747e-09 23 4649 True False 0.266666666666666 0.122362930299803 0.521107818970317 5.95202666507946e-05 1.50692154683113e-06 0.000331580585252994 0.997772828507795 0.99717737154042 0.998270111848726 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 40 1 39 9 52 11493 23655 0.000782472613458529 0.000357856744032263 0.00148485474620048 0.997806555025941 0.997124571279164 0.998361409801279 0.147540983606557 0.0697522979725587 0.261688088001952 0.025 0.000632744932049419 0.131585858482765 0.0188679245283018 0.000477580412422113 0.100701526769146 0.0527745985850919 0.00130728484520029 0.311972344114872 4.19999828578764e-06 25 3890 True False 0 0 0 0 0 0 0 0.35622854044937 0.154285052309675 0.729865511892806 8.70019140421089e-05 2.20269532804689e-06 0.000484647248975042 0.997806555025941 0.997124571279164 0.998361409801279 14 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Asn240Ser Rv2477c_p.Asn240Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 80.2910622977969 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Asn487His Rv2477c_p.Asn487His 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Asn535Ser Rv2477c_p.Asn535Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Asn80Lys Rv2477c_p.Asn80Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4452 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Asn88Ser Rv2477c_p.Asn88Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Asp101Asn Rv2477c_p.Asp101Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Asp101Glu Rv2477c_p.Asp101Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Asp113Tyr Rv2477c_p.Asp113Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4457 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3726 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Asp133Tyr Rv2477c_p.Asp133Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Asp146Tyr Rv2477c_p.Asp146Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4446 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3718 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Asp17_Lys18insAsnAsp Rv2477c_p.Asp17_Lys18insAsnAsp 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Asp179Gly Rv2477c_p.Asp179Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Asp17Asn Rv2477c_p.Asp17Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Asp220Gly Rv2477c_p.Asp220Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.81634838479386 0.0231376410853604 142.42572627634 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 2.06121206851578 0.0262561678399451 161.601678830082 0.54664351365823 365.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Asp22Asn Rv2477c_p.Asp22Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 2 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Asp230Gly Rv2477c_p.Asp230Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Asp23del Rv2477c_p.Asp23del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Asp23Glu Rv2477c_p.Asp23Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Asp259Gly Rv2477c_p.Asp259Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4506 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3765 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Asp332Glu Rv2477c_p.Asp332Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4507 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3766 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Asp339Glu Rv2477c_p.Asp339Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 14 0 14 5 23 16805 30509 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 0.999246691995283 0.998869881214224 0.999522409302755 0.178571428571428 0.0606429088192075 0.368933349419203 0 0 0.231635761650116 0 0 0.148185128915224 0 0 0.547414190586106 0.00341905729146396 82 4649 False False 0.39466773605164 0.11718576995974 1.06165271382293 0 0 0.000219486736640675 0.999246691995283 0.998869881214224 0.999522409302755 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 80.2980353694986 1 1214.5 3890 False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 0 0 0.000320720684566658 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Asp374Asn Rv2477c_p.Asp374Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 11 16810 30521 0 0 0.000219421459229958 0.999639722258614 0.999355455254591 0.999820137367966 0 0 0.284914152918154 0 0 0.4592581264399 0 0 0.284914152918154 0 0 1.54226144562762 0.0957649318457096 183 4649 False False 0 0 0.723522114724776 0 0 0.000219421459229958 0.999639722258614 0.999355455254591 0.999820137367966 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 11 11502 23696 0 0 0.000320664925697395 0.999536002024718 0.999169931473241 0.999768351851939 0 0 0.284914152918154 0 0 0.4592581264399 0 0 0.284914152918154 0 0 1.75001723632703 0.186845837544336 223 3890 False False 0 0 0 0 0 0 0 0 0 0.821023972766749 0 0 0.000320664925697395 0.999536002024718 0.999169931473241 0.999768351851939 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Asp374Glu Rv2477c_p.Asp374Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Asp408Asn Rv2477c_p.Asp408Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Asp435Glu Rv2477c_p.Asp435Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Asp503Asn Rv2477c_p.Asp503Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Asp503Gly Rv2477c_p.Asp503Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 2.75133392880791 0.304355565478378 305.5 4649 False False 0 0 1.9820231071276 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3794 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Asp516Glu Rv2477c_p.Asp516Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Asp516His Rv2477c_p.Asp516His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4550 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3804 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Asp517_Asn518dup Rv2477c_p.Asp517_Asn518dup 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 9.66996583219897 0.541987658825864 457.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 10.9708654377183 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Asp517Ala Rv2477c_p.Asp517Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 4447 4649 False False Inf 1.1990579265185 Inf 0 0 0.000219473678051534 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3719 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Asp517Asn Rv2477c_p.Asp517Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4503 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Asp543Ala Rv2477c_p.Asp543Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Asp543Tyr Rv2477c_p.Asp543Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Asp55Ala Rv2477c_p.Asp55Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 7 16810 30525 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 0 0 0.409616397225003 0 0 0.4592581264399 0 0 0.409616397225003 0 0 1.54246355322091 0.0957757853990922 188.5 4649 False False 0 0 1.26007067420399 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Asp82Gly Rv2477c_p.Asp82Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Asp95Asn Rv2477c_p.Asp95Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Asp95Gly Rv2477c_p.Asp95Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4458 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Gln140Glu Rv2477c_p.Gln140Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Gln196His Rv2477c_p.Gln196His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 4 1 16806 30531 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999967247478055 0.999817528289014 0.999999170778282 0.8 0.28358206388191 0.994949236620532 0 0 0.975 0 0 0.975 0 0 70.7753052263996 1 1627.5 4649 False False 7.26669046769011 0.71899465830523 357.208630433948 0 0 0.000219473678051534 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Gln196Pro Rv2477c_p.Gln196Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Gln263Glu Rv2477c_p.Gln263Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Gln281His Rv2477c_p.Gln281His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4464 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3731 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Gln289Pro Rv2477c_p.Gln289Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4528 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3787 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Gln310His Rv2477c_p.Gln310His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Gln417His Rv2477c_p.Gln417His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4475 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3739 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Gln74His Rv2477c_p.Gln74His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 3 16809 30529 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999901742434167 0.999712876815577 0.99997973646933 0.25 0.00630946320970987 0.805879550316756 0 0 0.975 0 0 0.707598226178713 0 0 70.7580573242674 1 1627.5 4649 False False 0.605409800305391 0.0115361654751757 7.54087213596152 0 0 0.000219434511605659 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 80.2773259044493 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Glu117Ala Rv2477c_p.Glu117Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Glu120Asp Rv2477c_p.Glu120Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Glu127Asp Rv2477c_p.Glu127Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Glu128Asp Rv2477c_p.Glu128Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Glu128Lys Rv2477c_p.Glu128Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Glu142Lys Rv2477c_p.Glu142Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4439 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3712 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Glu224Lys Rv2477c_p.Glu224Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.75142405620251 0.304356294847217 327.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12235036001139 0.310791984491028 261 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Glu238Asp Rv2477c_p.Glu238Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Glu238Val Rv2477c_p.Glu238Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 16809 30529 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999901742434167 0.999712876815577 0.99997973646933 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.39581433818102 0.556927644280045 795 4649 False False 0.605409800305391 0.0115361654751757 7.54087213596152 0 0 0.000219434511605659 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Glu250Ala Rv2477c_p.Glu250Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 9.67028206568003 0.541992006917746 476.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 10.9713274274722 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Glu268Lys Rv2477c_p.Glu268Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Glu269Lys Rv2477c_p.Glu269Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Glu293Asp Rv2477c_p.Glu293Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Glu308Asp Rv2477c_p.Glu308Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Glu308Lys Rv2477c_p.Glu308Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4459 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3727 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Glu323Ala Rv2477c_p.Glu323Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Glu323Leu Rv2477c_p.Glu323Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Glu404Asp Rv2477c_p.Glu404Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Glu447Ala Rv2477c_p.Glu447Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Glu476Ala Rv2477c_p.Glu476Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 80.2910622977969 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Glu476Lys Rv2477c_p.Glu476Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Glu513Ala Rv2477c_p.Glu513Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Glu513Lys Rv2477c_p.Glu513Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Glu519Asp Rv2477c_p.Glu519Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Glu519Lys Rv2477c_p.Glu519Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.9820231071276 0.168448731581911 252 4649 False False 0 0 1.9820231071276 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 2.24912710990902 0.180424970179968 177 3890 False False 0 0 0 0 0 0 0 0 0 2.24912710990902 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Glu533Gly Rv2477c_p.Glu533Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Glu538_Leu540delinsVal Rv2477c_p.Glu538_Leu540delinsVal 2 inframe_deletion (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4539 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3796 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Glu81Lys Rv2477c_p.Glu81Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Glu90Asp Rv2477c_p.Glu90Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Glu91Asp Rv2477c_p.Glu91Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Glu91Gly Rv2477c_p.Glu91Gly 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4545 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Gly123Asp Rv2477c_p.Gly123Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Gly162Ser Rv2477c_p.Gly162Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4535 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3792 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Gly207Asp Rv2477c_p.Gly207Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Gly207Cys Rv2477c_p.Gly207Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Gly207Ser Rv2477c_p.Gly207Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4467 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Gly232Asp Rv2477c_p.Gly232Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 6 16810 30526 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 4499 4649 False False 0 0 1.54251408011679 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 11502 23701 0 0 0.000320664925697395 0.9997469101953 0.999449212060655 0.99990711502044 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 3759 3890 False False 0 0 0 0 0 0 0 0 0 1.75038628279554 0 0 0.000320664925697395 0.9997469101953 0.999449212060655 0.99990711502044 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Gly256Ser Rv2477c_p.Gly256Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Gly314Arg Rv2477c_p.Gly314Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Gly31Ser Rv2477c_p.Gly31Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Gly395Asp Rv2477c_p.Gly395Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 4.39540875925228 0.556930310247326 910.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 4.98803779447094 0.555669835711629 381 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Gly409Ser Rv2477c_p.Gly409Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 70.7668929171829 1 1627.5 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 0 0 0.000219447565534303 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 80.2980353694986 1 1214.5 3890 False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 0 0 0.000320720684566658 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Gly416Ala Rv2477c_p.Gly416Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Gly41Glu Rv2477c_p.Gly41Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 244 125 16566 30407 0.0145151695419393 0.0127617934490269 0.0164393254865414 0.995905934756976 0.995124019209405 0.996591021303731 0.661246612466124 0.610454375323901 0.709426975413962 NA NA NA 0 0 0.0290798371364314 NA NA NA NA 4518 4649 False True 3.58290860799227 2.87396272020831 4.48560022365749 0 0 0.000222652949953309 0.995905934756976 0.995124019209405 0.996591021303731 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 127 83 11375 23624 0.0110415579899147 0.00921293021365061 0.0131235650208128 0.99649892436833 0.995661711782549 0.997210477144955 0.604761904761904 0.535158875337296 0.671363076130552 NA NA NA 0 0 0.0434711521664418 NA NA NA NA 3777 3890 False True 0 1 1 0 0 0 0 3.17780802330199 2.38862160129753 4.2463585011255 0 0 0.00032424451624814 0.99649892436833 0.995661711782549 0.997210477144955 19 5) Not assoc w R New NotAwR yes 5 +Rifampicin Rv2477c p.Gly433Val Rv2477c_p.Gly433Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4448 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3720 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Gly441Ala Rv2477c_p.Gly441Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 27 1 26 3 30 16807 30502 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999017424341674 0.998597606821861 0.999336965202819 0.0909090909090909 0.0191549429874049 0.243316350759155 0.037037037037037 0.000937257091944708 0.189705617413044 0.032258064516129 0.000816370071846613 0.167021116230227 0.0698015021213688 0.00170666708311139 0.42495564437021 0.000164253062297676 56 4649 True False 0.181483905515559 0.0354101922577551 0.583718899241087 5.94954783436458e-05 1.50629396217601e-06 0.000331442511213996 0.999017424341674 0.998597606821861 0.999336965202819 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 25 1 24 3 28 11499 23679 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.998818914244737 0.998293451150132 0.999215038088353 0.0967741935483871 0.0204198626877921 0.257539064627735 0.04 0.00101219969931084 0.203516913922414 0.0344827586206896 0.000872646883579922 0.177644295488722 0.0858009392121054 0.00209038948488282 0.52629557983788 0.000979421516057076 47 3890 False False 0 0 0 0 0 0 0 0.220630986545413 0.0429210167720432 0.714524195960815 8.69565217391304e-05 2.20154609696687e-06 0.000484394439799471 0.998818914244737 0.998293451150132 0.999215038088353 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Gly445Ser Rv2477c_p.Gly445Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Gly460Ser Rv2477c_p.Gly460Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Gly527Ser Rv2477c_p.Gly527Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4440 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3713 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Gly530Asp Rv2477c_p.Gly530Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Gly53Ser Rv2477c_p.Gly53Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Gly558Asp Rv2477c_p.Gly558Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Gly67Ser Rv2477c_p.Gly67Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 6 16810 30526 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 4504 4649 False False 0 0 1.54251408011679 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 11502 23701 0 0 0.000320664925697395 0.9997469101953 0.999449212060655 0.99990711502044 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 3762 3890 False False 0 0 0 0 0 0 0 0 0 1.75038628279554 0 0 0.000320664925697395 0.9997469101953 0.999449212060655 0.99990711502044 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Gly87Arg Rv2477c_p.Gly87Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4449 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Gly87Ser Rv2477c_p.Gly87Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 1 4 16809 30528 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999868989912223 0.999664596427238 0.999964303043777 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.75158776187525 0.30435761959971 350.5 4649 False False 0.454042477244333 0.00922341562850508 4.58878013974823 0 0 0.000219434511605659 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 1 4 11501 23703 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999831273463534 0.999568049920357 0.99995402584539 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12262191820896 0.310798846422045 285 3890 False False 0 0 0 0 0 0 0 0.515237805408225 0.0104655802548345 5.20753049950472 0 0 0.000320692802708327 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Gly92_Met93insIle Rv2477c_p.Gly92_Met93insIle 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4471 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3736 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Gly92Arg Rv2477c_p.Gly92Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.His189Tyr Rv2477c_p.His189Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 19 6 16791 30526 0.00113027959547888 0.000680635004098699 0.00176451134196716 0.999803484868334 0.999572318737888 0.999927879105266 0.76 0.548711982183313 0.906435560668257 NA NA NA 0 0 0.4592581264399 NA NA NA NA 4481 4649 False False 5.75699283346237 2.2098350410968 17.6136949827745 0 0 0.000219669720190561 0.999803484868334 0.999572318737888 0.999927879105266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 16 5 11486 23702 0.00139106242392627 0.000795314835170056 0.00225801785882213 0.999789091829417 0.999507879904061 0.999931515258336 0.761904761904761 0.528340172345378 0.917824124406977 NA NA NA 0 0 0.521823750104981 NA NA NA NA 3744 3890 False False 0 0 0 0 0 0 0 6.60337802542225 2.31066740165822 23.0517608916169 0 0 0.000321111540268992 0.999789091829417 0.999507879904061 0.999931515258336 2 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.His201Asp Rv2477c_p.His201Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4460 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.His326Arg Rv2477c_p.His326Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.His548Arg Rv2477c_p.His548Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4546 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ile20Val Rv2477c_p.Ile20Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ile309Met Rv2477c_p.Ile309Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ile309Ser Rv2477c_p.Ile309Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4488 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3750 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ile311Met Rv2477c_p.Ile311Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 4491 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 0 0 0.000219447565534303 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 3753 3890 False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 0 0 0.000320720684566658 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ile311Thr Rv2477c_p.Ile311Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4510 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3769 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ile337Thr Rv2477c_p.Ile337Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4511 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3770 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ile34Thr Rv2477c_p.Ile34Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ile396Val Rv2477c_p.Ile396Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4561 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3814 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ile413Val Rv2477c_p.Ile413Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ile464Val Rv2477c_p.Ile464Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4441 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ile96Val Rv2477c_p.Ile96Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Leu109Phe Rv2477c_p.Leu109Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.75142405620251 0.304356294847217 327.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12235036001139 0.310791984491028 261 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 2 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Leu137Arg Rv2477c_p.Leu137Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Leu137Val Rv2477c_p.Leu137Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4508 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3767 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Leu148Pro Rv2477c_p.Leu148Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Leu160Arg Rv2477c_p.Leu160Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Leu198Phe Rv2477c_p.Leu198Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Leu198Val Rv2477c_p.Leu198Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 2 2 16808 30530 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999934494956111 0.999763393503742 0.99999206693684 0.5 0.067585986488543 0.932414013511457 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.67174719181657 0.54201215115422 740.5 4649 False False 1.8163969538315 0.131636449523742 25.0652602654423 0 0 0.000219447565534303 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 80.2980353694986 1 1214.5 3890 False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 0 0 0.000320720684566658 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Leu21Phe Rv2477c_p.Leu21Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Leu227Gln Rv2477c_p.Leu227Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 5 0 16805 30532 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 1 0.999879187193184 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 4465 4649 False False Inf 1.66460481015123 Inf 0 0 0.000219486736640675 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 5 0 11497 23707 0.00043470700747696 0.000141162766530747 0.00101416710312943 1 0.999844409142079 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 3732 3890 False False 0 0 0 0 0 0 0 Inf 1.88913119689894 Inf 0 0 0.000320804359238686 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Leu245Met Rv2477c_p.Leu245Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4492 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3754 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Leu288Val Rv2477c_p.Leu288Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 10 0 10 17 15 16793 30517 0.00101130279595478 0.000589228022589122 0.0016187015795436 0.999508712170837 0.99918982468991 0.9997250046892 0.53125 0.347436809286392 0.709060177093984 0 0 0.30849710781876 0 0 0.218019360910534 0 0 0.810850202789952 0.0177935006468137 124 4649 False False 2.05954465154131 0.967249147334238 4.42998313512479 0 0 0.000219643561005912 0.999508712170837 0.99918982468991 0.9997250046892 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 14 12 11488 23695 0.00121717962093548 0.000665598145642159 0.00204137811638842 0.999493820390602 0.999115973206486 0.999738423129043 0.538461538461538 0.333708218475292 0.734128782577048 0 0 0.409616397225003 0 0 0.264648469397051 0 0 1.43133946468956 0.10427979979889 142 3890 False False 0 0 0 0 0 0 0 2.40635155524605 1.03262139229019 5.69709470647891 0 0 0.000321055645424387 0.999493820390602 0.999115973206486 0.999738423129043 10 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Leu304Phe Rv2477c_p.Leu304Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Leu327His Rv2477c_p.Leu327His 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 8 16810 30524 0 0 0.000219421459229958 0.999737979824446 0.999483781433772 0.999886871715824 0 0 0.369416647552819 0 0 0.521823750104981 0 0 0.369416647552819 0 0 1.98182833524959 0.168442262219534 230 4649 False False 0 0 1.06393155676265 0 0 0.000219421459229958 0.999737979824446 0.999483781433772 0.999886871715824 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 7 11502 23700 0 0 0.000320664925697395 0.999704728561184 0.999391723222185 0.999881277590374 0 0 0.409616397225003 0 0 0.602364635616474 0 0 0.409616397225003 0 0 3.12195513230053 0.310781998687685 230 3890 False False 0 0 0 0 0 0 0 0 0 1.42986888806462 0 0 0.000320664925697395 0.999704728561184 0.999391723222185 0.999881277590374 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Leu327Phe Rv2477c_p.Leu327Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 4 7 16806 30525 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.99977073234639 0.999527678427408 0.999907817703152 0.363636363636363 0.109263443819098 0.692095284988322 0 0 0.602364635616474 0 0 0.409616397225003 0 0 2.7518085492516 0.30435940664955 358 4649 False False 1.03789462946906 0.22276865804861 4.08318190086053 0 0 0.000219473678051534 0.99977073234639 0.999527678427408 0.999907817703152 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 0 0 0.841886116991581 0 0 0.521823750104981 0 0 10.970403447915 1 504 3890 False False 0 0 0 0 0 0 0 0 0 2.24912710990902 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Leu370Arg Rv2477c_p.Leu370Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 6 16810 30526 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 1.9819581831673 0.168446574692961 237.5 4649 False False 0 0 1.54251408011679 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 4.98803779447094 0.555669835711629 381 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Leu453Phe Rv2477c_p.Leu453Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Leu455Ser Rv2477c_p.Leu455Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4551 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3805 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Leu473Arg Rv2477c_p.Leu473Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Leu481Val Rv2477c_p.Leu481Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4552 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3806 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Leu486Arg Rv2477c_p.Leu486Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Leu486Pro Rv2477c_p.Leu486Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Leu502Phe Rv2477c_p.Leu502Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Leu540Phe Rv2477c_p.Leu540Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 2 8 16808 30524 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999737979824446 0.999483781433772 0.999886871715824 0.2 0.0252107263268333 0.556095462307641 0 0 0.409616397225003 0 0 0.369416647552819 0 0 1.26017934487909 0.0561547297677373 164 4649 False False 0.454009995240361 0.0469649977420217 2.27541152741616 0 0 0.000219447565534303 0.999737979824446 0.999483781433772 0.999886871715824 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 1 5 11501 23702 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999789091829417 0.999507879904061 0.999931515258336 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.521823750104981 0 0 0.521823750104981 0 0 2.24932299250856 0.180435646558949 191.5 3890 False False 0 0 0 0 0 0 0 0.412172854534388 0.00871781959321125 3.68423590106777 0 0 0.000320692802708327 0.999789091829417 0.999507879904061 0.999931515258336 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Leu54Met Rv2477c_p.Leu54Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Leu54Ser Rv2477c_p.Leu54Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4556 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3810 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Leu64Gln Rv2477c_p.Leu64Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Leu73Pro Rv2477c_p.Leu73Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4509 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Lys10Glu Rv2477c_p.Lys10Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Lys13Glu Rv2477c_p.Lys13Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Lys278Asn Rv2477c_p.Lys278Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Lys303Glu Rv2477c_p.Lys303Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 3 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Lys329Arg Rv2477c_p.Lys329Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Lys338Glu Rv2477c_p.Lys338Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Lys33Arg Rv2477c_p.Lys33Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Lys33Asn Rv2477c_p.Lys33Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 10 16810 30522 0 0 0.000219421459229958 0.999672474780558 0.999397752220648 0.999842928110511 0 0 0.30849710781876 0 0 0.409616397225003 0 0 0.30849710781876 0 0 1.25994683820527 0.0561399108772532 144.5 4649 False False 0 0 0.81016282812198 0 0 0.000219421459229958 0.999672474780558 0.999397752220648 0.999842928110511 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 8 11502 23699 0 0 0.000320664925697395 0.999662546927068 0.999335191784523 0.999854300817065 0 0 0.369416647552819 0 0 0.4592581264399 0 0 0.369416647552819 0 0 1.75023866430665 0.186842544675657 221.5 3890 False False 0 0 0 0 0 0 0 0 0 1.20731769892417 0 0 0.000320664925697395 0.999662546927068 0.999335191784523 0.999854300817065 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Lys379Asn Rv2477c_p.Lys379Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 2 4 16808 30528 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999868989912223 0.999664596427238 0.999964303043777 0.333333333333333 0.0432718682927417 0.777221904496487 0.333333333333333 0.00840375865961264 0.905700675949754 0.2 0.00505076337946806 0.716417936118089 0.90813898143741 0.0153973078283344 17.4460082433985 1 1627.5 4649 False False 0.90813898143741 0.0821237468238322 6.33854635470206 5.94919388422868e-05 1.50620434989522e-06 0.000331422795737767 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.052853655209362 Inf 0.326658713928652 320 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 8.69489609599165e-05 2.20135467503192e-06 0.000484352330576856 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Lys385Thr Rv2477c_p.Lys385Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Lys400Gln Rv2477c_p.Lys400Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4533 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3790 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Lys458Asn Rv2477c_p.Lys458Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4485 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3747 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Lys458Glu Rv2477c_p.Lys458Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Lys99Thr Rv2477c_p.Lys99Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4536 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3793 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Met1? Rv2477c_p.Met1? 2 start_lost (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4493 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3755 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Met122Val Rv2477c_p.Met122Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 33 0 33 0 34 16810 30498 0 0 0.000219421459229958 0.998886414253897 0.998444219900326 0.999228690055086 0 0 0.102817924259012 0 0 0.105762810074579 0 0 0.102817924259012 0 0 0.214631258291764 9.78232246373897e-07 34 4649 True False 0 0 0.207976353060687 0 0 0.000219421459229958 0.998886414253897 0.998444219900326 0.999228690055086 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 33 0 33 0 34 11502 23673 0 0 0.000320664925697395 0.998565824440038 0.997996454606338 0.999006593594267 0 0 0.102817924259012 0 0 0.105762810074579 0 0 0.102817924259012 0 0 0.243487019117158 2.61156157811386e-06 22 3890 True False 0 0 0 0 0 0 0 0 0 0.235912930107953 0 0 0.000320664925697395 0.998565824440038 0.997996454606338 0.999006593594267 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Met51Val Rv2477c_p.Met51Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 80.2910622977969 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Met93Ile Rv2477c_p.Met93Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4529 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3788 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Phe28Val Rv2477c_p.Phe28Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Phe306Ser Rv2477c_p.Phe306Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Phe429Leu Rv2477c_p.Phe429Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4476 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3740 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Phe488Cys Rv2477c_p.Phe488Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Phe488Leu Rv2477c_p.Phe488Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4500 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3760 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Phe488Val Rv2477c_p.Phe488Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Phe4Ser Rv2477c_p.Phe4Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 1 16807 30531 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999967247478055 0.999817528289014 0.999999170778282 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 70.771098821806 1 1627.5 4649 False False 5.44969358005592 0.437509494081317 285.652299683162 0 0 0.000219460621016169 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Pro186Leu Rv2477c_p.Pro186Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Pro186Ser Rv2477c_p.Pro186Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4540 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Pro206Ala Rv2477c_p.Pro206Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4466 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3733 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Pro206Ser Rv2477c_p.Pro206Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Pro236His Rv2477c_p.Pro236His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4537 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Pro30Leu Rv2477c_p.Pro30Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4512 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3771 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Pro312Gln Rv2477c_p.Pro312Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Pro355Leu Rv2477c_p.Pro355Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Pro355Ser Rv2477c_p.Pro355Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4477 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3741 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Pro39Ser Rv2477c_p.Pro39Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 18 3 16792 30529 0.00107079119571683 0.000634738299600123 0.00169178580899694 0.999901742434167 0.999712876815577 0.99997973646933 0.857142857142857 0.636576012983019 0.969511032378484 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4543 4649 False False 10.908408766079 3.18381626063507 57.8230874797266 0 0 0.000219656639819404 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 17 3 11485 23704 0.00147800382542166 0.000861220016155565 0.00236537605429428 0.99987345509765 0.999630227076139 0.999973902638554 0.85 0.621073173454686 0.967929062814536 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3799 3890 False False 0 0 0 0 0 0 0 11.6954868669278 3.38160406077732 62.3387399637264 0 0 0.000321139494990277 0.99987345509765 0.999630227076139 0.999973902638554 2 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Pro421Leu Rv2477c_p.Pro421Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4442 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3714 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Pro434Gln Rv2477c_p.Pro434Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 8 0 16802 30532 0.000475907198096371 0.00020548462525215 0.000937510381255989 1 0.999879187193184 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 4541 4649 False False Inf 3.10133467016734 Inf 0 0 0.000219525921733526 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 7 0 11495 23707 0.000608589810467744 0.000244718560881119 0.00125352303681455 1 0.999844409142079 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 3797 3890 False False 0 0 0 0 0 0 0 Inf 2.97179240572548 Inf 0 0 0.000320860166613556 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Pro489Leu Rv2477c_p.Pro489Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 4557 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Pro489Ser Rv2477c_p.Pro489Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4544 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3800 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Pro547Leu Rv2477c_p.Pro547Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0465715996825058 Inf 0.355075831185839 416 4649 False False Inf 0.0465715996825058 Inf 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Pro57Leu Rv2477c_p.Pro57Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4443 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3715 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Pro77Leu Rv2477c_p.Pro77Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Pro77Ser Rv2477c_p.Pro77Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Pro77Thr Rv2477c_p.Pro77Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4522 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3781 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Pro78Ala Rv2477c_p.Pro78Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 4.39540875925228 0.556930310247326 910.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 10.9713274274722 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Pro78Gln Rv2477c_p.Pro78Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Pro78Ser Rv2477c_p.Pro78Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ser176Ala Rv2477c_p.Ser176Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4482 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ser176Pro Rv2477c_p.Ser176Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4547 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ser242Pro Rv2477c_p.Ser242Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ser27Gly Rv2477c_p.Ser27Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 9 16810 30523 0 0 0.000219421459229958 0.999705227302502 0.999440503684993 0.999865202576615 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 4523 4649 False False 0 0 0.920078094923294 0 0 0.000219421459229958 0.999705227302502 0.999440503684993 0.999865202576615 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3782 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ser27Ile Rv2477c_p.Ser27Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ser341Ala Rv2477c_p.Ser341Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4558 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3811 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ser341Trp Rv2477c_p.Ser341Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ser375Gly Rv2477c_p.Ser375Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 4478 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3742 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ser377Cys Rv2477c_p.Ser377Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 4548 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3802 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ser407Ala Rv2477c_p.Ser407Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ser407Leu Rv2477c_p.Ser407Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ser427Leu Rv2477c_p.Ser427Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4472 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3737 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ser46Asn Rv2477c_p.Ser46Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ser480Leu Rv2477c_p.Ser480Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ser480Trp Rv2477c_p.Ser480Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Ter559Glnext*? Rv2477c_p.Ter559Glnext*? 2 stop_lost (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Thr112Asn Rv2477c_p.Thr112Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4453 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3723 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Thr112Ile Rv2477c_p.Thr112Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Thr187Ala Rv2477c_p.Thr187Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4530 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Thr267Ile Rv2477c_p.Thr267Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4505 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3763 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Thr362Ala Rv2477c_p.Thr362Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4562 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3815 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Thr366Ala Rv2477c_p.Thr366Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 4486 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3748 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Thr372Lys Rv2477c_p.Thr372Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 75 16809 30457 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.997543560854185 0.996921791372149 0.998067379541612 0.0131578947368421 0.000333073571103066 0.071143691251719 NA NA NA 0 0 0.0479950640551422 NA NA NA NA 4468 4649 False True 0.024159279750927 0.00060831481424143 0.138783840462875 0 0 0.000219434511605659 0.997543560854185 0.996921791372149 0.998067379541612 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 1 70 11501 23637 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.997047285611844 0.996270874599881 0.997697512999019 0.0140845070422535 0.000356525274603389 0.0759934161211035 NA NA NA 0 0 0.0513337971510237 NA NA NA NA 3734 3890 False True 1 1 1 0 0 0 0 0.0293601798601363 0.000737439680161276 0.169057014693361 0 0 0.000320692802708327 0.997047285611844 0.996270874599881 0.997697512999019 5 5) Not assoc w R New NotAwR yes 5 +Rifampicin Rv2477c p.Thr418Ala Rv2477c_p.Thr418Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 80.2910622977969 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Thr505Arg Rv2477c_p.Thr505Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Thr505Met Rv2477c_p.Thr505Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Thr551Ile Rv2477c_p.Thr551Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Thr7Met Rv2477c_p.Thr7Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 70.7538526941519 1 1627.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Trp512Arg Rv2477c_p.Trp512Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Trp512Ser Rv2477c_p.Trp512Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Trp522Leu Rv2477c_p.Trp522Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4501 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3761 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Trp524Arg Rv2477c_p.Trp524Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4502 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Tyr114Asp Rv2477c_p.Tyr114Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Tyr114Cys Rv2477c_p.Tyr114Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Tyr114Ser Rv2477c_p.Tyr114Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Tyr237Cys Rv2477c_p.Tyr237Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4519 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3778 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Val106Ile Rv2477c_p.Val106Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4489 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3751 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Val157Ala Rv2477c_p.Val157Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Val168Ala Rv2477c_p.Val168Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4553 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3807 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Val195Met Rv2477c_p.Val195Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Val313Leu Rv2477c_p.Val313Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Val313Phe Rv2477c_p.Val313Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 4494 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3756 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Val320Met Rv2477c_p.Val320Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 9 16810 30523 0 0 0.000219421459229958 0.999705227302502 0.999440503684993 0.999865202576615 0 0 0.336267116879942 0 0 0.521823750104981 0 0 0.336267116879942 0 0 1.98176341129217 0.168440106635167 229 4649 False False 0 0 0.920078094923294 0 0 0.000219421459229958 0.999705227302502 0.999440503684993 0.999865202576615 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 9 11502 23698 0 0 0.000320664925697395 0.999620365292951 0.999279457952852 0.99982639261309 0 0 0.336267116879942 0 0 0.521823750104981 0 0 0.336267116879942 0 0 2.24874698315642 0.180404253865883 162 3890 False False 0 0 0 0 0 0 0 0 0 1.04405446176545 0 0 0.000320664925697395 0.999620365292951 0.999279457952852 0.99982639261309 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Val322Ile Rv2477c_p.Val322Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 70.7668929171829 1 1627.5 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 0 0 0.000219447565534303 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3764 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Val324Ala Rv2477c_p.Val324Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 70.7538526941519 1 1627.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3801 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Val324Ile Rv2477c_p.Val324Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4513 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3772 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Val350Phe Rv2477c_p.Val350Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Val352Ala Rv2477c_p.Val352Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4565 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3818 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Val358Ile Rv2477c_p.Val358Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4444 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3716 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Val368Phe Rv2477c_p.Val368Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 2 3 16808 30529 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999901742434167 0.999712876815577 0.99997973646933 0.4 0.0527449505263169 0.853367200365326 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.39607594248311 0.556925925901691 785 4649 False False 1.21089163890211 0.101157890363798 10.5697741171107 0 0 0.000219447565534303 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 2 3 11500 23704 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.99987345509765 0.999630227076139 0.999973902638554 0.4 0.0527449505263169 0.853367200365326 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98911614929625 0.555671755017244 473 3890 False False 0 0 0 0 0 0 0 1.37414492753623 0.114734681491877 11.9942804069209 0 0 0.000320720684566658 0.99987345509765 0.999630227076139 0.999973902638554 3 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Val384Leu Rv2477c_p.Val384Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4498 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Val389_Asp390insGly Rv2477c_p.Val389_Asp390insGly 2 inframe_insertion (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4559 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3812 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Val389Ala Rv2477c_p.Val389Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Val389Met Rv2477c_p.Val389Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Val405Gly Rv2477c_p.Val405Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 7 0 16803 30532 0.000416418798334324 0.000167437820935922 0.000857792460925722 1 0.999879187193184 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 4454 4649 False False Inf 2.61832748907777 Inf 0 0 0.000219512858481393 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3724 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Val406Phe Rv2477c_p.Val406Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4495 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3757 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Val420Ala Rv2477c_p.Val420Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Val426Ala Rv2477c_p.Val426Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 2 3 16808 30529 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999901742434167 0.999712876815577 0.99997973646933 0.4 0.0527449505263169 0.853367200365326 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.39607594248311 0.556925925901691 785 4649 False False 1.21089163890211 0.101157890363798 10.5697741171107 0 0 0.000219447565534303 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 2 3 11500 23704 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.99987345509765 0.999630227076139 0.999973902638554 0.4 0.0527449505263169 0.853367200365326 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98911614929625 0.555671755017244 473 3890 False False 0 0 0 0 0 0 0 1.37414492753623 0.114734681491877 11.9942804069209 0 0 0.000320720684566658 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Val426Met Rv2477c_p.Val426Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 10 0 16800 30532 0.000594883997620464 0.000285305684944214 0.00109373983334496 1 0.999879187193184 1 1 0.691502892181239 1 NA NA NA NA NA NA NA NA NA NA 4566 4649 False False Inf 4.07313735951873 Inf 0 0 0.000219552052902727 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 9 0 11493 23707 0.000782472613458529 0.000357856744032263 0.00148485474620048 1 0.999844409142079 1 1 0.663732883120057 1 NA NA NA NA NA NA NA NA NA NA 3819 3890 False False 0 0 0 0 0 0 0 Inf 4.07050547199104 Inf 0 0 0.000320915993408392 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Val442Leu Rv2477c_p.Val442Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 4496 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3758 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Val475Gly Rv2477c_p.Val475Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Val493Met Rv2477c_p.Val493Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 4469 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3735 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Val542Ala Rv2477c_p.Val542Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Val550fs Rv2477c_p.Val550fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 4470 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Val550Leu Rv2477c_p.Val550Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Val70Ala Rv2477c_p.Val70Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 6 16808 30526 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999803484868334 0.999572318737888 0.999927879105266 0.25 0.0318540262499442 0.650855794412824 NA NA NA 0 0 0.4592581264399 NA NA NA NA 4461 4649 False False 0.605386323972711 0.0597336972185117 3.38610801139962 0 0 0.000219447565534303 0.999803484868334 0.999572318737888 0.999927879105266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 4 11501 23703 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999831273463534 0.999568049920357 0.99995402584539 0.2 0.00505076337946806 0.716417936118089 NA NA NA 0 0 0.602364635616474 NA NA NA NA 3728 3890 False False 0 0 0 0 0 0 0 0.515237805408225 0.0104655802548345 5.20753049950472 0 0 0.000320692802708327 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Val70Met Rv2477c_p.Val70Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Val85Ile Rv2477c_p.Val85Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 43 2 41 33 101 16777 30431 0.00196311719214753 0.00135169297871974 0.00275585192368924 0.996691995283636 0.995981905193951 0.997304792512653 0.246268656716417 0.175981317897862 0.328109467726735 0.0465116279069767 0.00568325697874796 0.158111458308697 0.0194174757281553 0.00236025793710863 0.0683859319003808 0.0884805998921287 0.0103637081695944 0.340708402861891 3.03377167668845e-06 38 4649 True False 0.592644810168565 0.38718889733757 0.886206783292858 0.000119196614816139 1.44355890240001e-05 0.000430512124347235 0.996691995283636 0.995981905193951 0.997304792512653 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 36 2 34 23 77 11479 23630 0.00199965223439401 0.00126801715451488 0.0029989585229059 0.996752014173029 0.995942222834204 0.997435916007205 0.23 0.151731611301047 0.324858732775103 0.0555555555555555 0.00680030065402281 0.186636706457554 0.0253164556962025 0.00308078078541997 0.0884769927956036 0.121090687342102 0.0140621304333199 0.472521165886651 0.00022841839297239 41 3890 True False 0 0 0 0 0 0 0 0.614889074685224 0.368038167632931 0.991139231603567 0.000174200853584182 2.10972278046313e-05 0.000629130213063368 0.996752014173029 0.995942222834204 0.997435916007205 3 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Val89Ala Rv2477c_p.Val89Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2477c p.Val89Met Rv2477c_p.Val89Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 70.7668929171829 1 1627.5 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 0 0 0.000219447565534303 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c c.1014G>T Rv2752c_c.1014G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1017G>A Rv2752c_c.1017G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1018C>T Rv2752c_c.1018C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1026C>G Rv2752c_c.1026C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1029C>G Rv2752c_c.1029C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1035G>A Rv2752c_c.1035G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.75142405620251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.12235036001139 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1050A>C Rv2752c_c.1050A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1050A>T Rv2752c_c.1050A>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.105A>G Rv2752c_c.105A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1063C>T Rv2752c_c.1063C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 17 58 16793 30474 0.00101130279595478 0.000589228022589122 0.0016187015795436 0.998100353727237 0.997544949665314 0.998557212644086 0.226666666666666 0.13793556763217 0.337921613704076 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.5318903401869 0.290272319811255 0.926561560612381 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 8 31 11494 23676 0.000695531211963136 0.000300327312744212 0.00137001129783907 0.998692369342388 0.998144431704435 0.999111360865311 0.205128205128205 0.0929639272829956 0.364644240695119 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.531576081770573 0.211078670148599 1.18265708482046 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1068C>T Rv2752c_c.1068C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1074C>T Rv2752c_c.1074C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 6 5 16804 30527 0.000356930398572278 0.000130998068917797 0.000776724091447791 0.999836237390279 0.999617874429585 0.999946824656822 0.545454545454545 0.233793597659345 0.832511905936292 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.17998095691502 0.554216105077683 9.03184671279788 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 5 11501 23702 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999789091829417 0.999507879904061 0.999931515258336 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.412172854534388 0.00871781959321125 3.68423590106777 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.-10T>C Rv2752c_c.-10T>C 2 upstream_gene_variant 3066201 1 1 0 1 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 70.7668929171829 1 1627.5 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 0 0 0.000219447565534303 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 80.2980353694986 1 1214.5 3890 False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 0 0 0.000320720684566658 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c c.1104A>G Rv2752c_c.1104A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1107G>A Rv2752c_c.1107G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1119C>G Rv2752c_c.1119C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.111G>A Rv2752c_c.111G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1122C>G Rv2752c_c.1122C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1122C>T Rv2752c_c.1122C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1128G>C Rv2752c_c.1128G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1134C>T Rv2752c_c.1134C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 15 16809 30517 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999508712170837 0.99918982468991 0.9997250046892 0.0625 0.00158111172276588 0.302320738434531 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.121034366510004 0.0028790007379686 0.786861037880772 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 14 11501 23693 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999409457122369 0.999009367705732 0.999677108302285 0.0666666666666666 0.0016864302413527 0.319484566578303 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.147148695144521 0.00348375000880481 0.967404595956322 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1137T>C Rv2752c_c.1137T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 6 7 16804 30525 0.000356930398572278 0.000130998068917797 0.000776724091447791 0.99977073234639 0.999527678427408 0.999907817703152 0.461538461538461 0.192232441801288 0.748654517729696 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.55702723841262 0.43221622692255 5.41149478110221 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 4 11499 23703 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.999831273463534 0.999568049920357 0.99995402584539 0.428571428571428 0.0989882784425078 0.815948432359917 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.54598225932689 0.226418767059518 9.13992940102341 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1141C>T Rv2752c_c.1141C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1144C>T Rv2752c_c.1144C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1152C>G Rv2752c_c.1152C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1155C>T Rv2752c_c.1155C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1158C>T Rv2752c_c.1158C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1161G>A Rv2752c_c.1161G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1167G>A Rv2752c_c.1167G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 15 16809 30517 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999508712170837 0.99918982468991 0.9997250046892 0.0625 0.00158111172276588 0.302320738434531 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.121034366510004 0.0028790007379686 0.786861037880772 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 6 11502 23701 0 0 0.000320664925697395 0.9997469101953 0.999449212060655 0.99990711502044 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.75038628279554 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1167G>T Rv2752c_c.1167G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1173C>T Rv2752c_c.1173C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.75142405620251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.12235036001139 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.120G>A Rv2752c_c.120G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1212C>G Rv2752c_c.1212C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1221C>T Rv2752c_c.1221C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.75142405620251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.12235036001139 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1225C>T Rv2752c_c.1225C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1239C>G Rv2752c_c.1239C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1239C>T Rv2752c_c.1239C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1242C>T Rv2752c_c.1242C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1248G>A Rv2752c_c.1248G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1251A>G Rv2752c_c.1251A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1269C>T Rv2752c_c.1269C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1275C>T Rv2752c_c.1275C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 4 16809 30528 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999868989912223 0.999664596427238 0.999964303043777 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.454042477244333 0.00922341562850508 4.58878013974823 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 4 11501 23703 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999831273463534 0.999568049920357 0.99995402584539 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.515237805408225 0.0104655802548345 5.20753049950472 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1278T>C Rv2752c_c.1278T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1281C>T Rv2752c_c.1281C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1287C>A Rv2752c_c.1287C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1287C>T Rv2752c_c.1287C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1290C>T Rv2752c_c.1290C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1311T>C Rv2752c_c.1311T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1314C>T Rv2752c_c.1314C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1317C>A Rv2752c_c.1317C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1317C>G Rv2752c_c.1317C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 14 11 16796 30521 0.000832837596668649 0.000455392489979272 0.00139696554892221 0.999639722258614 0.999355455254591 0.999820137367966 0.56 0.349281633991335 0.755976334852791 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.31274762389313 0.975118373095062 5.63074953061617 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 14 10 11488 23697 0.00121717962093548 0.000665598145642159 0.00204137811638842 0.999578183658835 0.999224402000993 0.999797704727851 0.583333333333333 0.366430645656362 0.778903094653321 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.88786559888579 1.19255671168369 7.26915550888986 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1320T>C Rv2752c_c.1320T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.135C>T Rv2752c_c.135C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.9820231071276 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.12235036001139 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1368C>T Rv2752c_c.1368C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1380C>T Rv2752c_c.1380C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1383C>A Rv2752c_c.1383C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1404G>A Rv2752c_c.1404G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1419C>A Rv2752c_c.1419C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1428C>T Rv2752c_c.1428C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1431C>T Rv2752c_c.1431C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1438A>C Rv2752c_c.1438A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1452C>T Rv2752c_c.1452C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1467G>A Rv2752c_c.1467G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1467G>T Rv2752c_c.1467G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1470A>G Rv2752c_c.1470A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1473T>C Rv2752c_c.1473T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 16810 30526 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.54251408011679 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.12235036001139 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1479C>T Rv2752c_c.1479C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1485G>A Rv2752c_c.1485G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1491C>T Rv2752c_c.1491C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1503C>T Rv2752c_c.1503C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 5 9 16805 30523 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 0.999705227302502 0.999440503684993 0.999865202576615 0.357142857142857 0.127598429859159 0.648619889384008 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.00905815068266 0.265595742451005 3.35339436934209 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 4 5 11498 23702 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 0.999789091829417 0.999507879904061 0.999931515258336 0.444444444444444 0.136995662265166 0.787991493221131 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.64912158636284 0.327175514256965 7.66332787722062 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1509G>A Rv2752c_c.1509G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1509G>T Rv2752c_c.1509G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.9820231071276 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1521C>T Rv2752c_c.1521C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1527C>T Rv2752c_c.1527C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1539A>C Rv2752c_c.1539A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1560C>T Rv2752c_c.1560C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 230 2110 16580 28422 0.0136823319452706 0.011981007193221 0.0155548353718213 0.930892178697759 0.92798957661182 0.933712468974962 0.0982905982905982 0.0865231757055652 0.111074251604638 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.186859632172605 0.162155323822786 0.214522515372823 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 169 1610 11333 22097 0.0146930968527212 0.0125742312897044 0.0170625048575316 0.932087569072425 0.928810503136428 0.935258218529026 0.0949971894322653 0.0817674473818735 0.109579294362794 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 0 0.204667674734313 0.173369122737862 0.240369918294534 NA NA NA NA NA NA 201 5) Not assoc w R Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1566C>T Rv2752c_c.1566C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.156C>T Rv2752c_c.156C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1572C>A Rv2752c_c.1572C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1596G>A Rv2752c_c.1596G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 8 16810 30524 0 0 0.000219421459229958 0.999737979824446 0.999483781433772 0.999886871715824 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.06393155676265 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 8 11502 23699 0 0 0.000320664925697395 0.999662546927068 0.999335191784523 0.999854300817065 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.20731769892417 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1599G>A Rv2752c_c.1599G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1602C>T Rv2752c_c.1602C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1608G>T Rv2752c_c.1608G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1614C>T Rv2752c_c.1614C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.75142405620251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.12235036001139 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1623G>A Rv2752c_c.1623G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.162G>A Rv2752c_c.162G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1635T>C Rv2752c_c.1635T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1638C>T Rv2752c_c.1638C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 3 16809 30529 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999901742434167 0.999712876815577 0.99997973646933 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.605409800305391 0.0115361654751757 7.54087213596152 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1656G>A Rv2752c_c.1656G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.908144446427509 0.0153974005043644 17.4461131425891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1662G>T Rv2752c_c.1662G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1671G>A Rv2752c_c.1671G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.1676A>G Rv2752c_c.1676A>G 2 stop_retained_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.-17C>G Rv2752c_c.-17C>G 2 upstream_gene_variant 3066208 1 2 1 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.81634838479386 0.0231376410853604 142.42572627634 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0528490600080728 Inf 0.32667783805277 340.5 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c c.183G>A Rv2752c_c.183G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 7 11 16803 30521 0.000416418798334324 0.000167437820935922 0.000857792460925722 0.999639722258614 0.999355455254591 0.999820137367966 0.388888888888888 0.172985854789751 0.642548794106937 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.15589207554927 0.379876343317803 3.26583528521413 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 7 9 11495 23698 0.000608589810467744 0.000244718560881119 0.00125352303681455 0.999620365292951 0.999279457952852 0.99982639261309 0.4375 0.197534140532667 0.701223100916822 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.60346044173795 0.507341469850139 4.8399285231588 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.201C>T Rv2752c_c.201C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.207C>T Rv2752c_c.207C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.210G>C Rv2752c_c.210G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.222C>T Rv2752c_c.222C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.229C>T Rv2752c_c.229C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.231G>C Rv2752c_c.231G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.234G>A Rv2752c_c.234G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 12 8 16798 30524 0.000713860797144556 0.000368914962606047 0.00124663876852724 0.999737979824446 0.999483781433772 0.999886871715824 0.6 0.360542587307489 0.808809939274692 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.72568162876532 1.02430321026523 7.68890030080649 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 12 8 11490 23699 0.0010432968179447 0.000539199208333142 0.00182171963730016 0.999662546927068 0.999335191784523 0.999854300817065 0.6 0.360542587307489 0.808809939274692 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.09386422976501 1.16251740293727 8.72760053501205 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.240C>T Rv2752c_c.240C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.75142405620251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.243C>T Rv2752c_c.243C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.249C>T Rv2752c_c.249C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.24A>G Rv2752c_c.24A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.264G>C Rv2752c_c.264G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.-26A>G Rv2752c_c.-26A>G 2 upstream_gene_variant 3066217 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c c.282C>G Rv2752c_c.282C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.-29C>T Rv2752c_c.-29C>T 2 upstream_gene_variant 3066220 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c c.306C>G Rv2752c_c.306C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.30C>T Rv2752c_c.30C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.-30T>C Rv2752c_c.-30T>C 2 upstream_gene_variant 3066221 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c c.312C>T Rv2752c_c.312C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.908144446427509 0.0153974005043644 17.4461131425891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.-31A>G Rv2752c_c.-31A>G 2 upstream_gene_variant 3066222 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c c.325T>C Rv2752c_c.325T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.330T>G Rv2752c_c.330T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.333G>C Rv2752c_c.333G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.339A>G Rv2752c_c.339A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.-34G>C Rv2752c_c.-34G>C 2 upstream_gene_variant 3066225 NA 0 0 0 19 0 16791 30532 0.00113027959547888 0.000680635004098699 0.00176451134196716 1 0.999879187193184 1 1 0.823533088193034 1 NA NA NA NA NA NA NA NA NA NA 3088 4649 False False Inf 8.48468002646117 Inf 0 0 0.000219669720190561 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 19 0 11483 23707 0.00165188662841245 0.000994827479836083 0.00257842889005257 1 0.999844409142079 1 1 0.823533088193034 1 NA NA NA NA NA NA NA NA NA NA 2574 3890 False False 0 0 0 0 0 0 0 Inf 9.63110800980318 Inf 0 0 0.000321195419037164 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c c.360C>T Rv2752c_c.360C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 17 16810 30515 0 0 0.000219421459229958 0.999443207126948 0.999108669858669 0.999675615241488 0 0 0.195064322969093 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.439992498211177 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 15 11502 23692 0 0 0.000320664925697395 0.999367275488252 0.9989566315242 0.999645827023281 0 0 0.218019360910534 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.574427270732117 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.366A>C Rv2752c_c.366A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.75142405620251 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.12235036001139 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.-36C>T Rv2752c_c.-36C>T 2 upstream_gene_variant 3066227 1 7 0 7 0 8 16810 30524 0 0 0.000219421459229958 0.999737979824446 0.999483781433772 0.999886871715824 0 0 0.369416647552819 0 0 0.409616397225003 0 0 0.369416647552819 0 0 1.26002939553565 0.0561451721436914 146.5 4649 False False 0 0 1.06393155676265 0 0 0.000219421459229958 0.999737979824446 0.999483781433772 0.999886871715824 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 8 11502 23699 0 0 0.000320664925697395 0.999662546927068 0.999335191784523 0.999854300817065 0 0 0.369416647552819 0 0 0.409616397225003 0 0 0.369416647552819 0 0 1.42980385016216 0.10425414010203 131 3890 False False 0 0 0 0 0 0 0 0 0 1.20731769892417 0 0 0.000320664925697395 0.999662546927068 0.999335191784523 0.999854300817065 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c c.378C>A Rv2752c_c.378C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.750576632084797 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.387C>G Rv2752c_c.387C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.387C>T Rv2752c_c.387C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.6329128986197 0.189104318453829 214.057761575796 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.-38T>G Rv2752c_c.-38T>G 2 upstream_gene_variant 3066229 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c c.-39_-32delCTTCGGTG Rv2752c_c.-39_-32delCTTCGGTG 2 upstream_gene_variant 3066222 1 2 1 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.81634838479386 0.0231376410853604 142.42572627634 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c c.39C>A Rv2752c_c.39C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.-3G>T Rv2752c_c.-3G>T 2 upstream_gene_variant 3066194 1 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2977 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2480 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c c.438C>T Rv2752c_c.438C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.450T>G Rv2752c_c.450T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.45G>T Rv2752c_c.45G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.-46C>T Rv2752c_c.-46C>T 2 upstream_gene_variant 3066237 1 0 0 0 11 1 16799 30531 0.00065437239738251 0.000326704163498642 0.00117055062018267 0.999967247478055 0.999817528289014 0.999999170778282 0.916666666666666 0.615203834849055 0.997892406768139 NA NA NA 0 0 0.975 NA NA NA NA 2829 4649 False False 19.9917256979582 2.90506952047996 857.005572217769 0 0 0.000219565120820351 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 11 1 11491 23706 0.000956355416449313 0.000477502787107626 0.00171053820723243 0.999957818365883 0.999765001636458 0.999998932054057 0.916666666666666 0.615203834849055 0.997892406768139 NA NA NA 0 0 0.975 NA NA NA NA 2362 3890 False False 0 0 0 0 0 0 0 22.6930641371508 3.29729020870041 972.205014864432 0 0 0.000320971839633333 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c c.477T>C Rv2752c_c.477T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 5 31 16805 30501 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 0.99898467181973 0.998559129586524 0.999310032760287 0.138888888888888 0.0466776606030902 0.294974948110631 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.292741215652023 0.0888679233918714 0.759594666020756 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 26 11501 23681 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.99890327751297 0.998393457445096 0.999283463292248 0.037037037037037 0.000937257091944708 0.189705617413044 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.0791937824804532 0.00193562529301197 0.482202433719514 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.-47C>T Rv2752c_c.-47C>T 2 upstream_gene_variant 3066238 1 0 0 0 11 1 16799 30531 0.00065437239738251 0.000326704163498642 0.00117055062018267 0.999967247478055 0.999817528289014 0.999999170778282 0.916666666666666 0.615203834849055 0.997892406768139 NA NA NA 0 0 0.975 NA NA NA NA 3157 4649 False False 19.9917256979582 2.90506952047996 857.005572217769 0 0 0.000219565120820351 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 11 1 11491 23706 0.000956355416449313 0.000477502787107626 0.00171053820723243 0.999957818365883 0.999765001636458 0.999998932054057 0.916666666666666 0.615203834849055 0.997892406768139 NA NA NA 0 0 0.975 NA NA NA NA 2623 3890 False False 0 0 0 0 0 0 0 22.6930641371508 3.29729020870041 972.205014864432 0 0 0.000320971839633333 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c c.480C>G Rv2752c_c.480C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.908144446427509 0.0153974005043644 17.4461131425891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.480C>T Rv2752c_c.480C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.908144446427509 0.0153974005043644 17.4461131425891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.496C>T Rv2752c_c.496C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.498G>C Rv2752c_c.498G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.-50C>A Rv2752c_c.-50C>A 2 upstream_gene_variant 3066241 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3038 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2532 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c c.513C>T Rv2752c_c.513C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.528G>A Rv2752c_c.528G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.549C>T Rv2752c_c.549C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 3 16809 30529 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999901742434167 0.999712876815577 0.99997973646933 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.605409800305391 0.0115361654751757 7.54087213596152 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.54C>T Rv2752c_c.54C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.553C>T Rv2752c_c.553C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.558G>T Rv2752c_c.558G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.561C>A Rv2752c_c.561C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.567G>A Rv2752c_c.567G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.576C>G Rv2752c_c.576C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.576C>T Rv2752c_c.576C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 12 52 16798 30480 0.000713860797144556 0.000368914962606047 0.00124663876852724 0.998296868858902 0.997767162428657 0.99872776667873 0.1875 0.100815159353777 0.304622873695148 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.418731167629846 0.203396606038493 0.795166104398943 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 9 40 11493 23667 0.000782472613458529 0.000357856744032263 0.00148485474620048 0.998312734635339 0.997703124720889 0.998794327736825 0.183673469387755 0.0875903353128472 0.320221214428868 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.463332028191072 0.197618626230008 0.970484013525314 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.585C>T Rv2752c_c.585C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 4 16807 30528 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999868989912223 0.999664596427238 0.999964303043777 0.428571428571428 0.0989882784425078 0.815948432359917 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.36228952222288 0.19952864446048 8.05486976701789 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 4 11500 23703 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999831273463534 0.999568049920357 0.99995402584539 0.333333333333333 0.0432718682927417 0.777221904496487 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.0305652173913 0.0931903474189042 7.19201282268065 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.588G>A Rv2752c_c.588G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.594G>A Rv2752c_c.594G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.598C>T Rv2752c_c.598C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.9820231071276 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.-5C>G Rv2752c_c.-5C>G 2 upstream_gene_variant 3066196 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c c.603C>T Rv2752c_c.603C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 2 16808 30530 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999934494956111 0.999763393503742 0.99999206693684 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.8163969538315 0.131636449523742 25.0652602654423 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.606C>T Rv2752c_c.606C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.612G>A Rv2752c_c.612G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.633C>A Rv2752c_c.633C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.639A>G Rv2752c_c.639A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.651A>G Rv2752c_c.651A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.654G>A Rv2752c_c.654G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.66C>T Rv2752c_c.66C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.675C>T Rv2752c_c.675C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 125 70 16685 30462 0.0074360499702558 0.00619338414045026 0.00885340275791868 0.997707323463906 0.99710421619596 0.998212323457036 0.641025641025641 0.569387529345295 0.708303401455807 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.26019949484138 2.41241338478234 4.4360704376427 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 45 47 11457 23660 0.00391236306729264 0.00285509282253167 0.00523158571947652 0.998017463196524 0.99736450840227 0.998542954015614 0.489130434782608 0.38340930836456 0.595570585042346 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.97723588106499 1.28325886904609 3.04308879681732 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.684T>C Rv2752c_c.684T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.684T>G Rv2752c_c.684T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 4.98824828790233 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.690C>T Rv2752c_c.690C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.699G>A Rv2752c_c.699G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.69C>T Rv2752c_c.69C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.-6C>T Rv2752c_c.-6C>T 2 upstream_gene_variant 3066197 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c c.708G>A Rv2752c_c.708G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 3 16809 30529 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999901742434167 0.999712876815577 0.99997973646933 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.605409800305391 0.0115361654751757 7.54087213596152 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 3 11501 23704 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.99987345509765 0.999630227076139 0.999973902638554 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.687012723531287 0.0130900577164196 8.55773267307823 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.711T>C Rv2752c_c.711T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.717C>G Rv2752c_c.717C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 4.3955527650214 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.720C>T Rv2752c_c.720C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.732G>A Rv2752c_c.732G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.908144446427509 0.0153974005043644 17.4461131425891 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.753C>T Rv2752c_c.753C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.756A>C Rv2752c_c.756A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.765G>A Rv2752c_c.765G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.771G>A Rv2752c_c.771G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.777G>A Rv2752c_c.777G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.786C>T Rv2752c_c.786C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.795G>T Rv2752c_c.795G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.801G>A Rv2752c_c.801G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 9.6705982991217 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 10.971789417177 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.804C>T Rv2752c_c.804C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.807C>T Rv2752c_c.807C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.819A>G Rv2752c_c.819A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 7 16810 30525 0 0 0.000219421459229958 0.99977073234639 0.999527678427408 0.999907817703152 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.26007067420399 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.12235036001139 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.828G>C Rv2752c_c.828G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.835C>T Rv2752c_c.835C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.840A>T Rv2752c_c.840A>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.843G>A Rv2752c_c.843G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.846T>G Rv2752c_c.846T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.858C>G Rv2752c_c.858C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.858C>T Rv2752c_c.858C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.861C>T Rv2752c_c.861C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.870C>T Rv2752c_c.870C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.876C>A Rv2752c_c.876C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.87C>T Rv2752c_c.87C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.882G>A Rv2752c_c.882G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.891C>G Rv2752c_c.891C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.891C>T Rv2752c_c.891C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.-8delG Rv2752c_c.-8delG 2 upstream_gene_variant 3066198 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c c.918C>A Rv2752c_c.918C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.81634838479386 0.0231376410853604 142.42572627634 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.-937_-936delAG Rv2752c_c.-937_-936delAG 2 upstream_gene_variant 3067126 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c c.-937A>T Rv2752c_c.-937A>T 2 upstream_gene_variant 3067128 NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3064 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2554 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c c.942G>A Rv2752c_c.942G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0465715996825058 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.-944C>T Rv2752c_c.-944C>T 2 upstream_gene_variant 3067135 1 2 0 2 24 31 16786 30501 0.00142772159428911 0.000914975681329737 0.00212359656152999 0.99898467181973 0.998559129586524 0.999310032760287 0.436363636363636 0.303036875277704 0.576783351044722 0 0 0.841886116991581 0 0 0.11218874692237 0 0 9.67521919832789 0.542059881102918 763 4649 False False 1.40674832713897 0.789750115846165 2.47723335873853 0 0 0.000219735145421064 0.99898467181973 0.998559129586524 0.999310032760287 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 21 29 11481 23678 0.00182576943140323 0.00113052422891288 0.00278953561568501 0.998776732610621 0.998243652703649 0.999180610346857 0.42 0.281882241123697 0.567939564934434 0 0 0.841886116991581 0 0 0.119444869069502 0 0 10.9793262287407 1 504 3890 False False 0 0 0 0 0 0 0 1.49343593162916 0.809133907944996 2.71226997007438 0 0 0.000321251362564953 0.998776732610621 0.998243652703649 0.999180610346857 3 3) Uncertain significance No change no 1 +Rifampicin Rv2752c c.-945A>G Rv2752c_c.-945A>G 2 upstream_gene_variant 3067136 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c c.-945delA Rv2752c_c.-945delA 2 upstream_gene_variant 3067135 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c c.-948G>A Rv2752c_c.-948G>A 2 upstream_gene_variant 3067139 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c c.-950A>G Rv2752c_c.-950A>G 2 upstream_gene_variant 3067141 NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2964 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2469 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c c.-951C>T Rv2752c_c.-951C>T 2 upstream_gene_variant 3067142 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c c.-951delC Rv2752c_c.-951delC 2 upstream_gene_variant 3067141 1 9 0 9 2 14 16808 30518 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999541464692781 0.999230775228684 0.999749292529582 0.125 0.0155136038154138 0.383476236849263 0 0 0.336267116879942 0 0 0.231635761650116 0 0 0.920036876538561 0.0314969103357443 128 4649 False False 0.259383286870197 0.0286095754721746 1.12958599765234 0 0 0.000219447565534303 0.999541464692781 0.999230775228684 0.999749292529582 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 1 9 11501 23698 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999620365292951 0.999279457952852 0.99982639261309 0.1 0.00252857854446178 0.445016117028195 0 0 0.409616397225003 0 0 0.336267116879942 0 0 1.42987285152999 0.104255222038515 138 3890 False False 0 0 0 0 0 0 0 0.228946275203122 0.00522688682241855 1.65262624160018 0 0 0.000320692802708327 0.999620365292951 0.999279457952852 0.99982639261309 6 3) Uncertain significance No change no 1 +Rifampicin Rv2752c c.-960A>G Rv2752c_c.-960A>G 2 upstream_gene_variant 3067151 1 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3001 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c c.-961G>A Rv2752c_c.-961G>A 2 upstream_gene_variant 3067152 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2785 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2325 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c c.966G>A Rv2752c_c.966G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 16 2 16794 30530 0.000951814396192742 0.000544138942285324 0.00154522796648703 0.999934494956111 0.999763393503742 0.99999206693684 0.888888888888888 0.652879561391328 0.986248784335635 NA NA NA NA NA NA NA NA NA NA NA NA False False 14.5432892699773 3.41854542181644 130.612716156442 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 16 2 11486 23705 0.00139106242392627 0.000795314835170056 0.00225801785882213 0.999915636731767 0.999695284447545 0.999989783053538 0.888888888888888 0.652879561391328 0.986248784335635 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 16.5105345638168 3.88047238533495 147.935140326109 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.-966G>T Rv2752c_c.-966G>T 2 upstream_gene_variant 3067157 1 0 0 0 1 25 16809 30507 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999181186951395 0.998791506081474 0.999470039476732 0.0384615384615384 0.00097328789333503 0.196369646762539 NA NA NA 0 0 0.137185171530712 NA NA NA NA 2978 4649 False False 0.0725968231304658 0.00177224844421437 0.443553154597488 0 0 0.000219434511605659 0.999181186951395 0.998791506081474 0.999470039476732 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 23 11501 23684 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.99902982241532 0.998544610722761 0.99938489435488 0.0416666666666666 0.00105435244546974 0.211201683456973 NA NA NA 0 0 0.148185128915224 NA NA NA NA 2481 3890 False False 0 0 0 0 0 0 0 0.0895347474510723 0.00217743413029611 0.551561418572831 0 0 0.000320692802708327 0.99902982241532 0.998544610722761 0.99938489435488 1 3) Uncertain significance No change no 1 +Rifampicin Rv2752c c.-967G>A Rv2752c_c.-967G>A 2 upstream_gene_variant 3067158 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c c.978C>T Rv2752c_c.978C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 70.7584826074924 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 80.2840904370714 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Rifampicin Rv2752c c.-981A>G Rv2752c_c.-981A>G 2 upstream_gene_variant 3067172 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c deletion Rv2752c_deletion 2 feature_ablation (see "Genomic_coordinates" sheet) NA 0 0 0 1 3 16809 30529 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999901742434167 0.999712876815577 0.99997973646933 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3158 4649 False False 0.605409800305391 0.0115361654751757 7.54087213596152 0 0 0.000219434511605659 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2624 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c LoF Rv2752c_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 110 2 108 368 156 16442 30376 0.021891731112433 0.0197329457327618 0.0242180566902203 0.994890606576706 0.994025545517213 0.995659326078198 0.702290076335877 0.661121688383153 0.741158881277655 0.0181818181818181 0.0022095371748962 0.0641375393774529 0.0126582278481012 0.00153666318632605 0.0449760547549854 0.0342122928183018 0.00411679139220365 0.126645377596405 5.13039390397386e-18 14 4649 True False 4.35811976208521 3.60034527386114 5.29559234925957 0.000121624908781318 1.47296801063034e-05 0.000439281198186607 0.994890606576706 0.994025545517213 0.995659326078198 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 89 1 88 241 120 11261 23587 0.0209528777603894 0.0184137131146191 0.0237383642282555 0.994938203906019 0.993950334039683 0.995801538565609 0.667590027700831 0.616385186680218 0.716018814707323 0.0112359550561797 0.000284429294948809 0.0610183043470826 0.00826446280991735 0.000209216193753886 0.0451861145207834 0.0238019794786511 0.000600508226708439 0.136159823148739 5.67528098800905e-14 14 3890 True False 0 0 0 0 0 0 0 4.20660317319361 3.36126989820821 5.28798767990725 8.87941751021133e-05 2.24807134844254e-06 0.000494629076463143 0.994938203906019 0.993950334039683 0.995801538565609 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ala110fs Rv2752c_p.Ala110fs 2 frameshift (see "Genomic_coordinates" sheet) 1 5 0 5 2 5 16808 30527 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999836237390279 0.999617874429585 0.999946824656822 0.285714285714285 0.0366925661760855 0.709579136262657 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.98225896975909 0.168456568596501 274 4649 False False 0.726487386958591 0.069161301215026 4.43811993507661 0 0 0.000219447565534303 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ala110Ser Rv2752c_p.Ala110Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2949 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2457 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ala113Glu Rv2752c_p.Ala113Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ala113Gly Rv2752c_p.Ala113Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2795 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2334 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ala153Val Rv2752c_p.Ala153Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 4.3952647534881 0.556931257223419 920.5 4649 False False 0 0 1.9820231071276 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 4.98782730104768 0.555669461962421 375.5 3890 False False 0 0 0 0 0 0 0 0 0 2.24912710990902 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ala155Thr Rv2752c_p.Ala155Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ala155Val Rv2752c_p.Ala155Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2927 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2442 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ala157_Thr160del Rv2752c_p.Ala157_Thr160del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ala206Thr Rv2752c_p.Ala206Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3065 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ala206Val Rv2752c_p.Ala206Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ala20Glu Rv2752c_p.Ala20Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 1 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ala20Pro Rv2752c_p.Ala20Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.9820231071276 0.168448731581911 252 4649 False False 0 0 1.9820231071276 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12235036001139 0.310791984491028 261 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ala20Val Rv2752c_p.Ala20Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 2 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ala229fs Rv2752c_p.Ala229fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3159 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2625 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ala236Val Rv2752c_p.Ala236Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ala239Val Rv2752c_p.Ala239Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2810 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2346 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 1 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ala251Val Rv2752c_p.Ala251Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ala252dup Rv2752c_p.Ala252dup 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ala252Glu Rv2752c_p.Ala252Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2830 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2363 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ala252Thr Rv2752c_p.Ala252Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ala252Val Rv2752c_p.Ala252Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2913 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2429 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ala254dup Rv2752c_p.Ala254dup 2 inframe_insertion (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3012 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2509 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 2 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ala254Val Rv2752c_p.Ala254Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.9820231071276 0.168448731581911 252 4649 False False 0 0 1.9820231071276 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 2.24912710990902 0.180424970179968 177 3890 False False 0 0 0 0 0 0 0 0 0 2.24912710990902 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ala273Thr Rv2752c_p.Ala273Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 7 16808 30525 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.99977073234639 0.999527678427408 0.999907817703152 0.222222222222222 0.0281449734778982 0.600093573716312 NA NA NA 0 0 0.409616397225003 NA NA NA NA 3024 4649 False False 0.518885564697083 0.0525913141752312 2.72565212094981 0 0 0.000219447565534303 0.99977073234639 0.999527678427408 0.999907817703152 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 7 11500 23700 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999704728561184 0.999391723222185 0.999881277590374 0.222222222222222 0.0281449734778982 0.600093573716312 NA NA NA 0 0 0.409616397225003 NA NA NA NA 2521 3890 False False 0 0 0 0 0 0 0 0.588819875776397 0.0596633171436625 3.09306705863206 0 0 0.000320720684566658 0.999704728561184 0.999391723222185 0.999881277590374 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ala273Val Rv2752c_p.Ala273Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 108 16810 30424 0 0 0.000219421459229958 0.996462727630027 0.995730876957421 0.997097431333127 0 0 0.0335795502186544 NA NA NA 0 0 0.0335795502186544 NA NA NA NA NA NA False True 0 0 0.0629146369967448 0 0 0.000219421459229958 0.996462727630027 0.995730876957421 0.997097431333127 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 108 11502 23599 0 0 0.000320664925697395 0.995444383515417 0.994502422087473 0.996261486743148 0 0 0.0335795502186544 NA NA NA 0 0 0.0335795502186544 NA NA NA NA NA NA False True 1 1 1 0 0 1 0 0 0 0.0713109550419033 0 0 0.000320664925697395 0.995444383515417 0.994502422087473 0.996261486743148 NA Not assoc w R 5) Not assoc w R No change yes 1 +Rifampicin Rv2752c p.Ala282Gly Rv2752c_p.Ala282Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ala290fs Rv2752c_p.Ala290fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3089 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2575 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ala290Pro Rv2752c_p.Ala290Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ala292Asp Rv2752c_p.Ala292Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ala292del Rv2752c_p.Ala292del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ala296Val Rv2752c_p.Ala296Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 8 148 16802 30384 0.000475907198096371 0.00020548462525215 0.000937510381255989 0.99515262675226 0.994308156985689 0.995900637997656 0.0512820512820512 0.0223969965566744 0.0985437451681468 NA NA NA 0 0 0.0246168015789842 NA NA NA NA NA NA False True 0.0977489809771681 0.041433089128471 0.197784693518646 0 0 0.000219525921733526 0.99515262675226 0.994308156985689 0.995900637997656 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 6 112 11496 23595 0.000521648408972352 0.000191459062774625 0.00113506056981396 0.995275656978951 0.994318119361691 0.996108447551912 0.0508474576271186 0.0188861389890269 0.107390318369558 NA NA NA 0 0 0.0323999259313598 NA NA NA NA NA NA False True 0 1 1 0 0 1 0 0.109952840739636 0.0394727148996266 0.247027610760442 0 0 0.000320832260499258 0.995275656978951 0.994318119361691 0.996108447551912 21 Not assoc w R 5) Not assoc w R No change yes 1 +Rifampicin Rv2752c p.Ala330fs Rv2752c_p.Ala330fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 6 1 16804 30531 0.000356930398572278 0.000130998068917797 0.000776724091447791 0.999967247478055 0.999817528289014 0.999999170778282 0.857142857142857 0.421276802956804 0.996389703138099 NA NA NA 0 0 0.975 NA NA NA NA 3124 4649 False False 10.9013330159485 1.32231137693091 500.206066508325 0 0 0.000219499796783869 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2602 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ala347Thr Rv2752c_p.Ala347Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ala354Ser Rv2752c_p.Ala354Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ala368fs Rv2752c_p.Ala368fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2937 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ala376Glu Rv2752c_p.Ala376Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2950 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2458 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ala376Gly Rv2752c_p.Ala376Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 3 8 16807 30524 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999737979824446 0.999483781433772 0.999886871715824 0.272727272727272 0.0602177341729066 0.609742559572421 0 0 0.4592581264399 0 0 0.369416647552819 0 0 1.54268835746637 0.0957878616238008 208 4649 False False 0.681055512584042 0.116357116142111 2.83809201170135 0 0 0.000219460621016169 0.999737979824446 0.999483781433772 0.999886871715824 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 1 6 11501 23701 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.9997469101953 0.999449212060655 0.99990711502044 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.521823750104981 0 0 0.4592581264399 0 0 2.24922795223804 0.18043046509787 187.5 3890 False False 0 0 0 0 0 0 0 0.343462887285163 0.00747035147172492 2.83150389371471 0 0 0.000320692802708327 0.9997469101953 0.999449212060655 0.99990711502044 4 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ala376Val Rv2752c_p.Ala376Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2866 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2391 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ala378Thr Rv2752c_p.Ala378Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ala378Val Rv2752c_p.Ala378Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 11 1 16799 30531 0.00065437239738251 0.000326704163498642 0.00117055062018267 0.999967247478055 0.999817528289014 0.999999170778282 0.916666666666666 0.615203834849055 0.997892406768139 NA NA NA 0 0 0.975 NA NA NA NA 3170 4649 False False 19.9917256979582 2.90506952047996 857.005572217769 0 0 0.000219565120820351 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 5 1 11497 23706 0.00043470700747696 0.000141162766530747 0.00101416710312943 0.999957818365883 0.999765001636458 0.999998932054057 0.833333333333333 0.358765421002325 0.99578925548551 NA NA NA 0 0 0.975 NA NA NA NA 2631 3890 False False 0 0 0 0 0 0 0 10.3096459946072 1.15337945963023 486.419600220716 0 0 0.000320804359238686 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ala405fs Rv2752c_p.Ala405fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2796 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2335 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ala411Val Rv2752c_p.Ala411Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2990 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2492 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 2 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ala423fs Rv2752c_p.Ala423fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ala433Ser Rv2752c_p.Ala433Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2894 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2414 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ala436Asp Rv2752c_p.Ala436Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ala436Thr Rv2752c_p.Ala436Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 3 16809 30529 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999901742434167 0.999712876815577 0.99997973646933 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2914 4649 False False 0.605409800305391 0.0115361654751757 7.54087213596152 0 0 0.000219434511605659 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 3 11501 23704 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.99987345509765 0.999630227076139 0.999973902638554 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2430 3890 False False 0 0 0 0 0 0 0 0.687012723531287 0.0130900577164196 8.55773267307823 0 0 0.000320692802708327 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ala441Ser Rv2752c_p.Ala441Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 16810 30526 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.54251408011679 0.0957784996510068 197 4649 False False 0 0 1.54251408011679 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 2.24912710990902 0.180424970179968 177 3890 False False 0 0 0 0 0 0 0 0 0 2.24912710990902 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ala454fs Rv2752c_p.Ala454fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3039 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2533 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ala474Thr Rv2752c_p.Ala474Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ala474Val Rv2752c_p.Ala474Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 6 1 16804 30531 0.000356930398572278 0.000130998068917797 0.000776724091447791 0.999967247478055 0.999817528289014 0.999999170778282 0.857142857142857 0.421276802956804 0.996389703138099 0 0 0.975 0 0 0.975 0 0 70.7837195358556 1 1627.5 4649 False False 10.9013330159485 1.32231137693091 500.206066508325 0 0 0.000219499796783869 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ala489Val Rv2752c_p.Ala489Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ala503Gly Rv2752c_p.Ala503Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3025 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2522 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ala520Ser Rv2752c_p.Ala520Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2831 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2364 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ala521Pro Rv2752c_p.Ala521Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ala521Ser Rv2752c_p.Ala521Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 2797 4649 False False 0 0 1.9820231071276 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 2336 3890 False False 0 0 0 0 0 0 0 0 0 2.24912710990902 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ala521Thr Rv2752c_p.Ala521Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2895 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ala530fs Rv2752c_p.Ala530fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2798 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ala530Thr Rv2752c_p.Ala530Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ala530Val Rv2752c_p.Ala530Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2965 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2470 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ala89Glu Rv2752c_p.Ala89Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3040 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2534 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Arg120fs Rv2752c_p.Arg120fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3090 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2576 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Arg120His Rv2752c_p.Arg120His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2896 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2415 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Arg17Gly Rv2752c_p.Arg17Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3013 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2510 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Arg17Trp Rv2752c_p.Arg17Trp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2811 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Arg224Leu Rv2752c_p.Arg224Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Arg227Gln Rv2752c_p.Arg227Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Arg227Gly Rv2752c_p.Arg227Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 1 4 16809 30528 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999868989912223 0.999664596427238 0.999964303043777 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.75158776187525 0.30435761959971 350.5 4649 False False 0.454042477244333 0.00922341562850508 4.58878013974823 0 0 0.000219434511605659 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 3 11501 23704 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.99987345509765 0.999630227076139 0.999973902638554 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98868218084989 0.555670981350655 466 3890 False False 0 0 0 0 0 0 0 0.687012723531287 0.0130900577164196 8.55773267307823 0 0 0.000320692802708327 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Arg227Trp Rv2752c_p.Arg227Trp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2832 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2365 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Arg232Gln Rv2752c_p.Arg232Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3125 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Arg244Gln Rv2752c_p.Arg244Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Arg244His Rv2752c_p.Arg244His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2991 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2493 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Arg244Trp Rv2752c_p.Arg244Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 9.67028206568003 0.541992006917746 476.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 10.9713274274722 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Arg257Trp Rv2752c_p.Arg257Trp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2966 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Arg258Gln Rv2752c_p.Arg258Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2878 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2402 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Arg258Leu Rv2752c_p.Arg258Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 3 17 16807 30515 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999443207126948 0.999108669858669 0.999675615241488 0.15 0.0320709371854637 0.378926826545313 0 0 0.841886116991581 0 0 0.195064322969093 0 0 9.66757739124367 0.541954818143702 446 4649 False False 0.320402213363479 0.0601549630539475 1.10798970023176 0 0 0.000219460621016169 0.999443207126948 0.999108669858669 0.999675615241488 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 2 8 11500 23699 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999662546927068 0.999335191784523 0.999854300817065 0.2 0.0252107263268333 0.556095462307641 0 0 0.841886116991581 0 0 0.369416647552819 0 0 10.9709217832299 1 1214.5 3890 False False 0 0 0 0 0 0 0 0.515195652173913 0.0532924302528778 2.58225829949872 0 0 0.000320720684566658 0.999662546927068 0.999335191784523 0.999854300817065 5 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Arg258* Rv2752c_p.Arg258* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2967 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2471 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Arg264Leu Rv2752c_p.Arg264Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3112 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Arg268Cys Rv2752c_p.Arg268Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Arg268His Rv2752c_p.Arg268His 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Arg271Cys Rv2752c_p.Arg271Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 9.67028206568003 0.541992006917746 476.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 10.9713274274722 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Arg280* Rv2752c_p.Arg280* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2887 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Arg29Cys Rv2752c_p.Arg29Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Arg29Gly Rv2752c_p.Arg29Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Arg317Pro Rv2752c_p.Arg317Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2849 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2379 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Arg320_Gly321insMetSerArg Rv2752c_p.Arg320_Gly321insMetSerArg 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 70.7668929171829 1 1627.5 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 0 0 0.000219447565534303 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Arg320His Rv2752c_p.Arg320His 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Arg320Leu Rv2752c_p.Arg320Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 1 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Arg320Pro Rv2752c_p.Arg320Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Arg361Gly Rv2752c_p.Arg361Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 14 0 14 4 17 16806 30515 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999443207126948 0.999108669858669 0.999675615241488 0.19047619047619 0.0544635681784068 0.419066041183528 0 0 0.231635761650116 0 0 0.195064322969093 0 0 0.547488998182631 0.00341945207103422 83 4649 False False 0.427228370819945 0.104563431958234 1.31008291875647 0 0 0.000219473678051534 0.999443207126948 0.999108669858669 0.999675615241488 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 14 0 14 4 17 11498 23690 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 0.999282912220019 0.998852120448669 0.999582216212894 0.19047619047619 0.0544635681784068 0.419066041183528 0 0 0.231635761650116 0 0 0.195064322969093 0 0 0.621281865833583 0.00734149946959926 75 3890 False False 0 0 0 0 0 0 0 0.484790193690974 0.118650919252931 1.48675721072847 0 0 0.000320776462830572 0.999282912220019 0.998852120448669 0.999582216212894 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Arg361Ser Rv2752c_p.Arg361Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Arg369fs Rv2752c_p.Arg369fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2799 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2337 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Arg389Gly Rv2752c_p.Arg389Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2897 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2416 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Arg389Trp Rv2752c_p.Arg389Trp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3066 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Arg391fs Rv2752c_p.Arg391fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2850 4649 False False Inf 1.1990579265185 Inf 0 0 0.000219473678051534 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Arg391Ser Rv2752c_p.Arg391Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2879 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Arg39fs Rv2752c_p.Arg39fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3014 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2511 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Arg39* Rv2752c_p.Arg39* 2 stop_gained (see "Genomic_coordinates" sheet) 1 2 0 2 3 2 16807 30530 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999934494956111 0.999763393503742 0.99999206693684 0.6 0.146632799634673 0.947255049473683 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.67232174050862 0.542020050820051 749.5 4649 False False 2.72475754150056 0.312074221533576 32.6324551811023 0 0 0.000219460621016169 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 80.2980353694986 1 1214.5 3890 False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 0 0 0.000320720684566658 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Arg401Gly Rv2752c_p.Arg401Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Arg404Ser Rv2752c_p.Arg404Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Arg465Leu Rv2752c_p.Arg465Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Arg465Trp Rv2752c_p.Arg465Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 10 3 16800 30529 0.000594883997620464 0.000285305684944214 0.00109373983334496 0.999901742434167 0.999712876815577 0.99997973646933 0.769230769230769 0.461868460765959 0.949618926508848 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.39816989869617 0.556912213757214 770 4649 False False 6.05734126984126 1.55931702668942 34.2318335698778 0 0 0.000219552052902727 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 7 2 11495 23705 0.000608589810467744 0.000244718560881119 0.00125352303681455 0.999915636731767 0.999695284447545 0.999989783053538 0.777777777777777 0.399906426283687 0.971855026522101 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.9784590641073 1 1214.5 3890 False False 0 0 0 0 0 0 0 7.21770334928229 1.37393085985684 71.363027934548 0 0 0.000320860166613556 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Arg481His Rv2752c_p.Arg481His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2968 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2472 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Arg495dup Rv2752c_p.Arg495dup 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3015 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Arg528Gln Rv2752c_p.Arg528Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3002 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Arg534fs Rv2752c_p.Arg534fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3016 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2512 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Arg535Cys Rv2752c_p.Arg535Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 15 0 16795 30532 0.000892325996430696 0.000499511372123772 0.00147132963433071 1 0.999879187193184 1 1 0.781980639089466 1 NA NA NA NA NA NA NA NA NA NA 3078 4649 False False Inf 6.51893136980533 Inf 0 0 0.00021961740805081 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 14 0 11488 23707 0.00121717962093548 0.000665598145642159 0.00204137811638842 1 0.999844409142079 1 1 0.768364238349883 1 NA NA NA NA NA NA NA NA NA NA 2564 3890 False False 0 0 0 0 0 0 0 Inf 6.84328477771802 Inf 0 0 0.000321055645424387 1 0.999844409142079 1 5 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Arg547Cys Rv2752c_p.Arg547Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3049 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Arg547fs Rv2752c_p.Arg547fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2867 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2392 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Arg547His Rv2752c_p.Arg547His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2906 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2423 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Arg65His Rv2752c_p.Arg65His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Arg65Ser Rv2752c_p.Arg65Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 9.67028206568003 0.541992006917746 476.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Arg97fs Rv2752c_p.Arg97fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 7 1 16803 30531 0.000416418798334324 0.000167437820935922 0.000857792460925722 0.999967247478055 0.999817528289014 0.999999170778282 0.875 0.473490329124793 0.996840276468748 0 0 0.975 0 0 0.975 0 0 70.7879274408962 1 938.5 4649 False False 12.7189787537939 1.63372483035451 571.646572779703 0 0 0.000219512858481393 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 1 11499 23706 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.999957818365883 0.999765001636458 0.999998932054057 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 80.3050096524922 1 1214.5 3890 False False 0 0 0 0 0 0 0 6.18471171406209 0.496496186771195 324.103527365594 0 0 0.000320748571273651 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Arg97Gln Rv2752c_p.Arg97Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3003 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2501 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Arg97* Rv2752c_p.Arg97* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 5 1 16805 30531 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 0.999967247478055 0.999817528289014 0.999999170778282 0.833333333333333 0.358765421002325 0.99578925548551 0 0 0.975 0 0 0.975 0 0 70.7795121310531 1 1627.5 4649 False False 9.08390360011901 1.01631102884943 428.726615606949 0 0 0.000219486736640675 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Asn269Asp Rv2752c_p.Asn269Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Asn30Asp Rv2752c_p.Asn30Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2812 4649 False False Inf 1.1990579265185 Inf 0 0 0.000219473678051534 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 11498 23707 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 1 0.999844409142079 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2347 3890 False False 0 0 0 0 0 0 0 Inf 1.3608069907404 Inf 0 0 0.000320776462830572 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Asn30His Rv2752c_p.Asn30His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3004 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2502 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Asn30Lys Rv2752c_p.Asn30Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 11 2 16799 30530 0.00065437239738251 0.000326704163498642 0.00117055062018267 0.999934494956111 0.999763393503742 0.99999206693684 0.846153846153846 0.545528944323442 0.980793328017471 0 0 0.975 0 0 0.841886116991581 0 0 70.8024475961574 1 1627.5 4649 False False 9.9955354485386 2.18100854358387 92.8265896741658 0 0 0.000219565120820351 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 11 1 11491 23706 0.000956355416449313 0.000477502787107626 0.00171053820723243 0.999957818365883 0.999765001636458 0.999998932054057 0.916666666666666 0.615203834849055 0.997892406768139 NA NA NA 0 0 0.975 NA NA NA NA 2593 3890 False False 0 0 0 0 0 0 0 22.6930641371508 3.29729020870041 972.205014864432 0 0 0.000320971839633333 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Asn30Ser Rv2752c_p.Asn30Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 3 2 9 10 16801 30522 0.000535395597858417 0.000244845253515427 0.00101610321951737 0.999672474780558 0.999397752220648 0.999842928110511 0.473684210526315 0.244474689466196 0.711356752083001 0.6 0.146632799634673 0.947255049473683 0.23076923076923 0.0503810734911515 0.53813153923404 2.72501636807332 0.312103867041903 32.6355433375838 0.354633743893774 378 4649 False False 1.63500982084399 0.587711564735598 4.4781038034966 0.000178528921685313 3.68184689870195e-05 0.000521647743502508 0.999672474780558 0.999397752220648 0.999842928110511 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 3 0 9 7 11493 23700 0.000782472613458529 0.000357856744032263 0.00148485474620048 0.999704728561184 0.999391723222185 0.999881277590374 0.5625 0.298776899083177 0.802465859467332 1 0.292401773821286 1 0.3 0.0667395111777345 0.652452850059997 Inf 0.851981952286401 Inf 0.0348404708205684 94 3890 False False 0 0 0 0 0 0 0 2.65130327777156 0.878336932348038 8.37909316341309 0.000260960334029227 5.38195281624569e-05 0.000762445558728535 0.999704728561184 0.999391723222185 0.999881277590374 3 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Asn30Tyr Rv2752c_p.Asn30Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2992 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Asn344fs Rv2752c_p.Asn344fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2993 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Asn386Asp Rv2752c_p.Asn386Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2843 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2375 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Asn392fs Rv2752c_p.Asn392fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3026 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Asn406Lys Rv2752c_p.Asn406Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3079 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2565 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Asn406Ser Rv2752c_p.Asn406Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2938 4649 False False 0.908144446427509 0.0153974005043644 17.4461131425891 0 0 0.000219434511605659 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2450 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Asn425Lys Rv2752c_p.Asn425Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2800 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2338 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Asn522Asp Rv2752c_p.Asn522Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Asn522fs Rv2752c_p.Asn522fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3113 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2594 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Asp152Ala Rv2752c_p.Asp152Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 3 3 16807 30529 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999901742434167 0.999712876815577 0.99997973646933 0.5 0.118117248757025 0.881882751242974 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.39633757793323 0.556924208491887 781 4649 False False 1.81644552864877 0.243258979140325 13.5672775646283 0 0 0.000219460621016169 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.9727417274169 1 1214.5 3890 False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 0 0 0.000320692802708327 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Asp152fs Rv2752c_p.Asp152fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3099 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Asp170_Gly195del Rv2752c_p.Asp170_Gly195del 2 inframe_deletion (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3160 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Asp170Asn Rv2752c_p.Asp170Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 14 0 14 2 18 16808 30514 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999410454605004 0.999068423526975 0.999650561796013 0.1 0.0123485271702948 0.316982714019082 0 0 0.231635761650116 0 0 0.185301968137852 0 0 0.547406193515012 0.00341901581498283 80 4649 False False 0.201716114019778 0.0226963968810346 0.842717806922828 0 0 0.000219447565534303 0.999410454605004 0.999068423526975 0.999650561796013 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 2 13 11500 23694 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999451638756485 0.999062468123692 0.999707989454911 0.133333333333333 0.0165759134400836 0.404602696603372 0 0 0.30849710781876 0 0 0.24705263800047 0 0 0.919391062537471 0.0366163832513038 106 3890 False False 0 0 0 0 0 0 0 0.316976588628762 0.0347137069593318 1.40051862845351 0 0 0.000320720684566658 0.999451638756485 0.999062468123692 0.999707989454911 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Asp170fs Rv2752c_p.Asp170fs 2 frameshift (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.75142405620251 0.304356294847217 327.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12235036001139 0.310791984491028 261 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Asp170Gly Rv2752c_p.Asp170Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 5 0 16805 30532 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 1 0.999879187193184 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 2851 4649 False False Inf 1.66460481015123 Inf 0 0 0.000219486736640675 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2380 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Asp174_Gln175insHis Rv2752c_p.Asp174_Gln175insHis 2 inframe_insertion (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2951 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2459 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Asp174fs Rv2752c_p.Asp174fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2994 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2494 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Asp174Glu Rv2752c_p.Asp174Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2888 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Asp179fs Rv2752c_p.Asp179fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3126 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Asp184fs Rv2752c_p.Asp184fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2868 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2393 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Asp184Glu Rv2752c_p.Asp184Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 9.67028206568003 0.541992006917746 476.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 10.9713274274722 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Asp184Gly Rv2752c_p.Asp184Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Asp184His Rv2752c_p.Asp184His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2898 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2417 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 1 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Asp193Asn Rv2752c_p.Asp193Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3050 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Asp202Ala Rv2752c_p.Asp202Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 3 16809 30529 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999901742434167 0.999712876815577 0.99997973646933 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 9.6708564591744 0.541999904097594 709 4649 False False 0.605409800305391 0.0115361654751757 7.54087213596152 0 0 0.000219434511605659 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 3 11501 23704 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.99987345509765 0.999630227076139 0.999973902638554 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 10.9722796976426 1 1214.5 3890 False False 0 0 0 0 0 0 0 0.687012723531287 0.0130900577164196 8.55773267307823 0 0 0.000320692802708327 0.99987345509765 0.999630227076139 0.999973902638554 3 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Asp202Tyr Rv2752c_p.Asp202Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3027 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2523 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Asp230Gly Rv2752c_p.Asp230Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3127 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2603 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Asp230Tyr Rv2752c_p.Asp230Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2952 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Asp243fs Rv2752c_p.Asp243fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2889 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Asp250Glu Rv2752c_p.Asp250Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Asp298fs Rv2752c_p.Asp298fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3091 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2577 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Asp332fs Rv2752c_p.Asp332fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2928 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2443 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Asp332Gly Rv2752c_p.Asp332Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 8 1 16802 30531 0.000475907198096371 0.00020548462525215 0.000937510381255989 0.999967247478055 0.999817528289014 0.999999170778282 0.888888888888888 0.517503485082663 0.9971908632534 0 0 0.975 0 0 0.975 0 0 70.7921358462643 1 938.5 4649 False False 14.5368408522794 1.94857414115003 643.047530935858 0 0 0.000219525921733526 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 5 1 11497 23706 0.00043470700747696 0.000141162766530747 0.00101416710312943 0.999957818365883 0.999765001636458 0.999998932054057 0.833333333333333 0.358765421002325 0.99578925548551 0 0 0.975 0 0 0.975 0 0 80.3189618536173 1 1214.5 3890 False False 0 0 0 0 0 0 0 10.3096459946072 1.15337945963023 486.419600220716 0 0 0.000320804359238686 0.999957818365883 0.999765001636458 0.999998932054057 2 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Asp332Tyr Rv2752c_p.Asp332Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3067 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Asp430Ala Rv2752c_p.Asp430Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2833 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Asp44Ala Rv2752c_p.Asp44Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2929 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Asp44Glu Rv2752c_p.Asp44Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2899 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2418 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Asp44Gly Rv2752c_p.Asp44Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2869 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2394 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Asp450Gly Rv2752c_p.Asp450Gly 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 10 1 16800 30531 0.000594883997620464 0.000285305684944214 0.00109373983334496 0.999967247478055 0.999817528289014 0.999999170778282 0.909090909090909 0.587220083011617 0.997701027786185 NA NA NA 0 0 0.975 NA NA NA NA 2930 4649 False False 18.1732142857142 2.58478875004711 785.727835535391 0 0 0.000219552052902727 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 3 1 11499 23706 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.999957818365883 0.999765001636458 0.999998932054057 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 2444 3890 False False 0 0 0 0 0 0 0 6.18471171406209 0.496496186771195 324.103527365594 0 0 0.000320748571273651 0.999957818365883 0.999765001636458 0.999998932054057 5 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Asp4fs Rv2752c_p.Asp4fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Asp500fs Rv2752c_p.Asp500fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3161 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2626 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Asp58Glu Rv2752c_p.Asp58Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3051 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2542 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Asp63Ala Rv2752c_p.Asp63Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2852 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Asp63Gly Rv2752c_p.Asp63Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 3 3 16807 30529 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999901742434167 0.999712876815577 0.99997973646933 0.5 0.118117248757025 0.881882751242974 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.39633757793323 0.556924208491887 781 4649 False False 1.81644552864877 0.243258979140325 13.5672775646283 0 0 0.000219460621016169 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 2 2 11500 23705 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999915636731767 0.999695284447545 0.999989783053538 0.5 0.067585986488543 0.932414013511457 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.973694203073 1 504 3890 False False 0 0 0 0 0 0 0 2.06130434782608 0.149383229063395 28.4413197127326 0 0 0.000320720684566658 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Asp69Asn Rv2752c_p.Asp69Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2907 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2424 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Asp72fs Rv2752c_p.Asp72fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3128 4649 False False Inf 1.1990579265185 Inf 0 0 0.000219473678051534 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 11498 23707 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 1 0.999844409142079 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2604 3890 False False 0 0 0 0 0 0 0 Inf 1.3608069907404 Inf 0 0 0.000320776462830572 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Asp72Glu Rv2752c_p.Asp72Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3100 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Asp73Glu Rv2752c_p.Asp73Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2813 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2348 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Asp85Ala Rv2752c_p.Asp85Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Asp85Asn Rv2752c_p.Asp85Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3041 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2535 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Asp85fs Rv2752c_p.Asp85fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3068 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Asp85Gly Rv2752c_p.Asp85Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 3 3 16807 30529 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999901742434167 0.999712876815577 0.99997973646933 0.5 0.118117248757025 0.881882751242974 0 0 0.841886116991581 0 0 0.707598226178713 0 0 9.67200545083345 0.542015701685608 745.5 4649 False False 1.81644552864877 0.243258979140325 13.5672775646283 0 0 0.000219460621016169 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 3 3 11499 23704 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.99987345509765 0.999630227076139 0.999973902638554 0.5 0.118117248757025 0.881882751242974 0 0 0.841886116991581 0 0 0.707598226178713 0 0 10.974184734254 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06139664318636 0.276050319534324 15.3984166853777 0 0 0.000320748571273651 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Asp99Asn Rv2752c_p.Asp99Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3101 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2582 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Cys116Phe Rv2752c_p.Cys116Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 16810 30526 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.54251408011679 0.0957784996510068 197 4649 False False 0 0 1.54251408011679 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 11502 23701 0 0 0.000320664925697395 0.9997469101953 0.999449212060655 0.99990711502044 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.75038628279554 0.186840354932931 214 3890 False False 0 0 0 0 0 0 0 0 0 1.75038628279554 0 0 0.000320664925697395 0.9997469101953 0.999449212060655 0.99990711502044 1 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Cys141fs Rv2752c_p.Cys141fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3042 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2536 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Cys201Arg Rv2752c_p.Cys201Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 70.7668929171829 1 1627.5 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 0 0 0.000219447565534303 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 80.2980353694986 1 1214.5 3890 False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 0 0 0.000320720684566658 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Cys201fs Rv2752c_p.Cys201fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3092 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Cys201* Rv2752c_p.Cys201* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3102 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2583 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Cys201Tyr Rv2752c_p.Cys201Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Cys237Arg Rv2752c_p.Cys237Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2969 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Cys45* Rv2752c_p.Cys45* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2970 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2473 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Cys45Tyr Rv2752c_p.Cys45Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3017 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2513 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Gln132fs Rv2752c_p.Gln132fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Gln132Pro Rv2752c_p.Gln132Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 2 5 16808 30527 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999836237390279 0.999617874429585 0.999946824656822 0.285714285714285 0.0366925661760855 0.709579136262657 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.98225896975909 0.168456568596501 274 4649 False False 0.726487386958591 0.069161301215026 4.43811993507661 0 0 0.000219447565534303 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 1 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Gln132* Rv2752c_p.Gln132* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Gln175His Rv2752c_p.Gln175His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2834 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2366 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Gln175* Rv2752c_p.Gln175* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Gln246Arg Rv2752c_p.Gln246Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Gln246Pro Rv2752c_p.Gln246Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3140 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2611 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Gln246* Rv2752c_p.Gln246* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 9 0 16801 30532 0.000535395597858417 0.000244845253515427 0.00101610321951737 1 0.999879187193184 1 1 0.663732883120057 1 NA NA NA NA NA NA NA NA NA NA 3069 4649 False False Inf 3.58631764003717 Inf 0 0 0.000219538986540545 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 7 0 11495 23707 0.000608589810467744 0.000244718560881119 0.00125352303681455 1 0.999844409142079 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 2555 3890 False False 0 0 0 0 0 0 0 Inf 2.97179240572548 Inf 0 0 0.000320860166613556 1 0.999844409142079 1 2 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Gln247* Rv2752c_p.Gln247* 2 stop_gained (see "Genomic_coordinates" sheet) 1 11 1 10 70 22 16740 30510 0.00416418798334324 0.00324758416539656 0.00525831335367222 0.999279444517227 0.998909272375137 0.999548378362908 0.760869565217391 0.660636758950986 0.843667727780328 0.0909090909090909 0.00229897221381426 0.412779916988382 0.0434782608695652 0.0011001686304415 0.21948660745348 0.182258064516129 0.0042035136006807 1.28139042091301 0.110669697317981 215 4649 False False 5.7991202346041 3.5464416754646 9.8391617052913 5.97335881966429e-05 1.51232237261462e-06 0.000332768812881134 0.999279444517227 0.998909272375137 0.999548378362908 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 1 10 30 16 11472 23691 0.00260824204486176 0.00176044063976377 0.00372135102988799 0.999325093854136 0.99890422546949 0.999614185177149 0.652173913043478 0.497509949327036 0.786456445748494 0.0909090909090909 0.00229897221381426 0.412779916988382 0.0588235294117647 0.00148817439126663 0.28688939666722 0.20651150627615 0.00476212352542569 1.45199127142278 0.116516264861763 158 3890 False False 0 0 0 0 0 0 0 3.87209074267782 2.04358527511338 7.60884308513024 8.71611609866643e-05 2.20672710272231e-06 0.000485534162995498 0.999325093854136 0.99890422546949 0.999614185177149 6 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Gln275Arg Rv2752c_p.Gln275Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Gln275* Rv2752c_p.Gln275* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Gln299Arg Rv2752c_p.Gln299Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Gln308Glu Rv2752c_p.Gln308Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Gln308His Rv2752c_p.Gln308His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2814 4649 False False Inf 1.1990579265185 Inf 0 0 0.000219473678051534 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2349 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Gln308Pro Rv2752c_p.Gln308Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 2 2 16808 30530 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999934494956111 0.999763393503742 0.99999206693684 0.5 0.067585986488543 0.932414013511457 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.67174719181657 0.54201215115422 740.5 4649 False False 1.8163969538315 0.131636449523742 25.0652602654423 0 0 0.000219447565534303 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 80.2980353694986 1 1214.5 3890 False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 0 0 0.000320720684566658 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Gln308* Rv2752c_p.Gln308* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 2 2 16808 30530 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999934494956111 0.999763393503742 0.99999206693684 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 70.7645776857468 1 1627.5 4649 False False 1.8163969538315 0.131636449523742 25.0652602654423 0 0 0.000219447565534303 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 2367 3890 False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 0 0 0.000320720684566658 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Gln367Pro Rv2752c_p.Gln367Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 5 0 16805 30532 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 1 0.999879187193184 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 3070 4649 False False Inf 1.66460481015123 Inf 0 0 0.000219486736640675 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 11498 23707 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 1 0.999844409142079 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2556 3890 False False 0 0 0 0 0 0 0 Inf 1.3608069907404 Inf 0 0 0.000320776462830572 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Gln367* Rv2752c_p.Gln367* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Gln417* Rv2752c_p.Gln417* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 70.7668929171829 1 1627.5 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 0 0 0.000219447565534303 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 80.2980353694986 1 1214.5 3890 False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 0 0 0.000320720684566658 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Gln485Arg Rv2752c_p.Gln485Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Gln485Pro Rv2752c_p.Gln485Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2786 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2326 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Gln531Glu Rv2752c_p.Gln531Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3028 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2524 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Gln531Pro Rv2752c_p.Gln531Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3018 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2514 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Gln531* Rv2752c_p.Gln531* 2 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3162 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2627 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Gln548fs Rv2752c_p.Gln548fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2953 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Glu114Gly Rv2752c_p.Glu114Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 6 16810 30526 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 0 0 0.4592581264399 0 0 0.602364635616474 0 0 0.4592581264399 0 0 2.75124380141528 0.304354836583622 299.5 4649 False False 0 0 1.54251408011679 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 6 11502 23701 0 0 0.000320664925697395 0.9997469101953 0.999449212060655 0.99990711502044 0 0 0.4592581264399 0 0 0.602364635616474 0 0 0.4592581264399 0 0 3.12208687486085 0.310785326665151 232 3890 False False 0 0 0 0 0 0 0 0 0 1.75038628279554 0 0 0.000320664925697395 0.9997469101953 0.999449212060655 0.99990711502044 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Glu130Lys Rv2752c_p.Glu130Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3080 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2566 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Glu140fs Rv2752c_p.Glu140fs 2 frameshift (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 16809 30529 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999901742434167 0.999712876815577 0.99997973646933 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.39581433818102 0.556927644280045 795 4649 False False 0.605409800305391 0.0115361654751757 7.54087213596152 0 0 0.000219434511605659 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.9727417274169 1 1214.5 3890 False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 0 0 0.000320692802708327 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Glu142Gly Rv2752c_p.Glu142Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3114 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Glu142* Rv2752c_p.Glu142* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 80.2910622977969 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Glu207Lys Rv2752c_p.Glu207Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Glu217Asp Rv2752c_p.Glu217Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Glu217* Rv2752c_p.Glu217* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3171 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2632 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Glu26Gly Rv2752c_p.Glu26Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Glu310Ala Rv2752c_p.Glu310Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Glu310fs Rv2752c_p.Glu310fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3103 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2584 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Glu322* Rv2752c_p.Glu322* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3129 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Glu345Lys Rv2752c_p.Glu345Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3115 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2595 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Glu345* Rv2752c_p.Glu345* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2915 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2431 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Glu346fs Rv2752c_p.Glu346fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2900 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2419 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Glu35Asp Rv2752c_p.Glu35Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Glu35fs Rv2752c_p.Glu35fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3104 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2585 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Glu380Ala Rv2752c_p.Glu380Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Glu380Lys Rv2752c_p.Glu380Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2835 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2368 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Glu380* Rv2752c_p.Glu380* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2995 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2495 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Glu424Gly Rv2752c_p.Glu424Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3005 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2503 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Glu464Gly Rv2752c_p.Glu464Gly 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3141 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Glu464Lys Rv2752c_p.Glu464Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2815 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2350 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Glu499fs Rv2752c_p.Glu499fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 6 0 16804 30532 0.000356930398572278 0.000130998068917797 0.000776724091447791 1 0.999879187193184 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 2853 4649 False False Inf 2.13890645017026 Inf 0 0 0.000219499796783869 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 6 0 11496 23707 0.000521648408972352 0.000191459062774625 0.00113506056981396 1 0.999844409142079 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 2381 3890 False False 0 0 0 0 0 0 0 Inf 2.42738974088595 Inf 0 0 0.000320832260499258 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Glu499Gly Rv2752c_p.Glu499Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3130 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2605 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Glu499* Rv2752c_p.Glu499* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Glu505Gln Rv2752c_p.Glu505Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3142 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2612 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Glu516* Rv2752c_p.Glu516* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2954 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Glu543fs Rv2752c_p.Glu543fs 2 frameshift (see "Genomic_coordinates" sheet) 1 4 0 4 11 5 16799 30527 0.00065437239738251 0.000326704163498642 0.00117055062018267 0.999836237390279 0.999617874429585 0.999946824656822 0.6875 0.413379363548641 0.889830045282882 0 0 0.602364635616474 0 0 0.521823750104981 0 0 2.75313570451292 0.304370222538251 367 4649 False False 3.99782129888683 1.28021914521895 14.6804531160199 0 0 0.000219565120820351 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 7 3 11495 23704 0.000608589810467744 0.000244718560881119 0.00125352303681455 0.99987345509765 0.999630227076139 0.999973902638554 0.7 0.347547149940002 0.933260488822265 0 0 0.841886116991581 0 0 0.707598226178713 0 0 10.977996793769 1 1214.5 3890 False False 0 0 0 0 0 0 0 4.811599246049 1.0981171989898 28.8594402321863 0 0 0.000320860166613556 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Glu543* Rv2752c_p.Glu543* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3052 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2543 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Glu54Ala Rv2752c_p.Glu54Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 2 5 16808 30527 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999836237390279 0.999617874429585 0.999946824656822 0.285714285714285 0.0366925661760855 0.709579136262657 0 0 0.602364635616474 0 0 0.521823750104981 0 0 2.75166134890834 0.304358214896098 355 4649 False False 0.726487386958591 0.069161301215026 4.43811993507661 0 0 0.000219447565534303 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12235036001139 0.310791984491028 261 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Glu54Gly Rv2752c_p.Glu54Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3131 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Glu557Gly Rv2752c_p.Glu557Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Glu68Asp Rv2752c_p.Glu68Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 13 0 13 0 15 16810 30517 0 0 0.000219421459229958 0.999508712170837 0.99918982468991 0.9997250046892 0 0 0.218019360910534 0 0 0.24705263800047 0 0 0.218019360910534 0 0 0.595766711398166 0.00617861351943865 99 4649 False False 0 0 0.506230693741096 0 0 0.000219421459229958 0.999508712170837 0.99918982468991 0.9997250046892 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 13 0 13 0 15 11502 23692 0 0 0.000320664925697395 0.999367275488252 0.9989566315242 0.999645827023281 0 0 0.218019360910534 0 0 0.24705263800047 0 0 0.218019360910534 0 0 0.676011695235014 0.00721794144863922 69 3890 False False 0 0 0 0 0 0 0 0 0 0.574427270732117 0 0 0.000320664925697395 0.999367275488252 0.9989566315242 0.999645827023281 2 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Glu68* Rv2752c_p.Glu68* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2787 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2327 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Glu75* Rv2752c_p.Glu75* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3143 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2613 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Glu84Asp Rv2752c_p.Glu84Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3029 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2525 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Glu84Lys Rv2752c_p.Glu84Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Gly104Ala Rv2752c_p.Gly104Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 1 4 16809 30528 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999868989912223 0.999664596427238 0.999964303043777 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.75158776187525 0.30435761959971 350.5 4649 False False 0.454042477244333 0.00922341562850508 4.58878013974823 0 0 0.000219434511605659 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.9727417274169 1 1214.5 3890 False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 0 0 0.000320692802708327 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Gly15Arg Rv2752c_p.Gly15Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Gly161Arg Rv2752c_p.Gly161Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2931 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Gly161Cys Rv2752c_p.Gly161Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Gly161fs Rv2752c_p.Gly161fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2979 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2482 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Gly161Ser Rv2752c_p.Gly161Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 54 149 16756 30383 0.0032123735871505 0.00241412734534404 0.00418939791764501 0.995119874230315 0.994272800291201 0.995870504559598 0.266009852216748 0.206590109270178 0.332401447435311 NA NA NA 0 0 0.02445362490559 NA NA NA NA NA NA False True 0.65715496482478 0.471860426137497 0.903415659387533 0 0 0.000220128516676725 0.995119874230315 0.994272800291201 0.995870504559598 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 36 100 11466 23607 0.00312989045383411 0.00219307036741769 0.00433048000210719 0.995781836588349 0.994871924889757 0.996566655603578 0.264705882352941 0.192786993660625 0.347163805990346 NA NA NA 0 0 0.0362166926451764 NA NA NA NA NA NA False True 0 1 1 0 0 1 0 0.741193092621664 0.4913714649428 1.09567802587988 0 0 0.000321671561005972 0.995781836588349 0.994871924889757 0.996566655603578 20 Not assoc w R 5) Not assoc w R No change yes 1 +Rifampicin Rv2752c p.Gly163Arg Rv2752c_p.Gly163Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 9.67028206568003 0.541992006917746 476.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 10.9713274274722 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Gly169Arg Rv2752c_p.Gly169Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3105 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2586 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Gly169Val Rv2752c_p.Gly169Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3172 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2633 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Gly180Cys Rv2752c_p.Gly180Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3132 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2606 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Gly180fs Rv2752c_p.Gly180fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Gly187Asp Rv2752c_p.Gly187Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 2916 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 0 0 0.000219447565534303 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2432 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Gly210Arg Rv2752c_p.Gly210Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2854 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2382 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Gly210Asp Rv2752c_p.Gly210Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2855 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2383 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Gly210fs Rv2752c_p.Gly210fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Gly219Ser Rv2752c_p.Gly219Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3019 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2515 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Gly228Cys Rv2752c_p.Gly228Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2996 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2496 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Gly228fs Rv2752c_p.Gly228fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2816 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2351 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Gly22Cys Rv2752c_p.Gly22Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Gly22Ser Rv2752c_p.Gly22Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3163 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Gly22Val Rv2752c_p.Gly22Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2890 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2409 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Gly231Val Rv2752c_p.Gly231Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 3106 4649 False False 0 0 1.9820231071276 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 2587 3890 False False 0 0 0 0 0 0 0 0 0 2.24912710990902 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Gly256fs Rv2752c_p.Gly256fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3053 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2544 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Gly256Ser Rv2752c_p.Gly256Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2817 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Gly256Val Rv2752c_p.Gly256Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Gly263Asp Rv2752c_p.Gly263Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2880 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2403 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Gly263fs Rv2752c_p.Gly263fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3144 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2614 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Gly28Cys Rv2752c_p.Gly28Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3133 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Gly28Ser Rv2752c_p.Gly28Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 15 0 16795 30532 0.000892325996430696 0.000499511372123772 0.00147132963433071 1 0.999879187193184 1 1 0.781980639089466 1 NA NA NA NA NA NA NA NA NA NA 2856 4649 False False Inf 6.51893136980533 Inf 0 0 0.00021961740805081 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 15 0 11487 23707 0.00130412102243088 0.000730084557867185 0.00215003854003137 1 0.999844409142079 1 1 0.781980639089466 1 NA NA NA NA NA NA NA NA NA NA 2384 3890 False False 0 0 0 0 0 0 0 Inf 7.40065484717093 Inf 0 0 0.000321083590414119 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Gly28Val Rv2752c_p.Gly28Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Gly306Asp Rv2752c_p.Gly306Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2939 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2451 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Gly321Thr Rv2752c_p.Gly321Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2857 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Gly331fs Rv2752c_p.Gly331fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 70.7668929171829 1 1627.5 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 0 0 0.000219447565534303 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 80.2910622977969 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Gly331Ser Rv2752c_p.Gly331Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3030 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Gly331Val Rv2752c_p.Gly331Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Gly343Cys Rv2752c_p.Gly343Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Gly350Glu Rv2752c_p.Gly350Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2881 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Gly374Arg Rv2752c_p.Gly374Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2788 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Gly374Asp Rv2752c_p.Gly374Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3145 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2615 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Gly387Arg Rv2752c_p.Gly387Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3020 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2516 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Gly387Glu Rv2752c_p.Gly387Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3164 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2628 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Gly38fs Rv2752c_p.Gly38fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3116 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2596 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Gly38Ser Rv2752c_p.Gly38Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Gly398Arg Rv2752c_p.Gly398Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3165 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Gly414Asp Rv2752c_p.Gly414Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3093 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2578 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Gly414Ser Rv2752c_p.Gly414Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.75142405620251 0.304356294847217 327.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 1 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Gly426Ala Rv2752c_p.Gly426Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Gly440Ser Rv2752c_p.Gly440Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Gly445fs Rv2752c_p.Gly445fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3054 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2545 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 2 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Gly451Asp Rv2752c_p.Gly451Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Gly451Ser Rv2752c_p.Gly451Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 5 0 16805 30532 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 1 0.999879187193184 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 2971 4649 False False Inf 1.66460481015123 Inf 0 0 0.000219486736640675 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 5 0 11497 23707 0.00043470700747696 0.000141162766530747 0.00101416710312943 1 0.999844409142079 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 2474 3890 False False 0 0 0 0 0 0 0 Inf 1.88913119689894 Inf 0 0 0.000320804359238686 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Gly458Arg Rv2752c_p.Gly458Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.75142405620251 0.304356294847217 327.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12235036001139 0.310791984491028 261 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Gly458Asp Rv2752c_p.Gly458Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Gly463Arg Rv2752c_p.Gly463Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Gly46Cys Rv2752c_p.Gly46Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3134 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2607 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Gly46fs Rv2752c_p.Gly46fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2844 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2376 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Gly482Val Rv2752c_p.Gly482Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Gly484Ser Rv2752c_p.Gly484Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3146 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Gly496Ala Rv2752c_p.Gly496Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 1 6 16809 30526 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999803484868334 0.999572318737888 0.999927879105266 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.54260585225547 0.0957834295462749 205.5 4649 False False 0.302675154183274 0.00658396461982027 2.49513982006856 0 0 0.000219434511605659 0.999803484868334 0.999572318737888 0.999927879105266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 1 5 11501 23702 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999789091829417 0.999507879904061 0.999931515258336 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.521823750104981 0 0 0.521823750104981 0 0 2.24932299250856 0.180435646558949 191.5 3890 False False 0 0 0 0 0 0 0 0.412172854534388 0.00871781959321125 3.68423590106777 0 0 0.000320692802708327 0.999789091829417 0.999507879904061 0.999931515258336 2 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Gly496Asp Rv2752c_p.Gly496Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2908 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2425 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Gly496fs Rv2752c_p.Gly496fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2789 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2328 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Gly51Ser Rv2752c_p.Gly51Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Gly542Glu Rv2752c_p.Gly542Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Gly56fs Rv2752c_p.Gly56fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 8 5 16802 30527 0.000475907198096371 0.00020548462525215 0.000937510381255989 0.999836237390279 0.999617874429585 0.999946824656822 0.615384615384615 0.315777602914063 0.861420661109839 0 0 0.841886116991581 0 0 0.521823750104981 0 0 9.67424635745701 0.542046513010273 758 4649 False False 2.90698726342102 0.838334102961652 11.2954727017352 0 0 0.000219525921733526 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 6 3 11496 23704 0.000521648408972352 0.000191459062774625 0.00113506056981396 0.99987345509765 0.999630227076139 0.999973902638554 0.666666666666666 0.29929505620854 0.925145368580308 0 0 0.841886116991581 0 0 0.707598226178713 0 0 10.9770435304956 1 1214.5 3890 False False 0 0 0 0 0 0 0 4.12386917188587 0.880479664558533 25.486861327091 0 0 0.000320832260499258 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Gly56Val Rv2752c_p.Gly56Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3031 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2526 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Gly82Arg Rv2752c_p.Gly82Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Gly82Glu Rv2752c_p.Gly82Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 1 16807 30531 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999967247478055 0.999817528289014 0.999999170778282 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 70.771098821806 1 1627.5 4649 False False 5.44969358005592 0.437509494081317 285.652299683162 0 0 0.000219460621016169 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 1 11499 23706 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.999957818365883 0.999765001636458 0.999998932054057 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 80.3050096524922 1 1214.5 3890 False False 0 0 0 0 0 0 0 6.18471171406209 0.496496186771195 324.103527365594 0 0 0.000320748571273651 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Gly88Arg Rv2752c_p.Gly88Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3094 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Gly88Glu Rv2752c_p.Gly88Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3135 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2608 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 2 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Gly88Trp Rv2752c_p.Gly88Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2955 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2460 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Gly88Val Rv2752c_p.Gly88Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2940 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.His136Asp Rv2752c_p.His136Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.His148Arg Rv2752c_p.His148Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3055 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2546 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.His148dup Rv2752c_p.His148dup 2 inframe_insertion (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2858 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2385 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.His148Gln Rv2752c_p.His148Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.His148Pro Rv2752c_p.His148Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3032 4649 False False Inf 1.1990579265185 Inf 0 0 0.000219473678051534 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2527 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.His148Tyr Rv2752c_p.His148Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3071 4649 False False Inf 1.1990579265185 Inf 0 0 0.000219473678051534 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 11498 23707 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 1 0.999844409142079 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2557 3890 False False 0 0 0 0 0 0 0 Inf 1.3608069907404 Inf 0 0 0.000320776462830572 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.His167Arg Rv2752c_p.His167Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 7 3 16803 30529 0.000416418798334324 0.000167437820935922 0.000857792460925722 0.999901742434167 0.999712876815577 0.99997973646933 0.7 0.347547149940002 0.933260488822265 0 0 0.841886116991581 0 0 0.707598226178713 0 0 9.67430425317402 0.542047309778124 759.5 4649 False False 4.23938185641452 0.967624775502593 25.4084961789154 0 0 0.000219512858481393 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 5 3 11497 23704 0.00043470700747696 0.000141162766530747 0.00101416710312943 0.99987345509765 0.999630227076139 0.999973902638554 0.625 0.244863216366551 0.914766585862746 0 0 0.841886116991581 0 0 0.707598226178713 0 0 10.9760904328475 1 1214.5 3890 False False 0 0 0 0 0 0 0 3.43625873416253 0.668393407932569 22.1300557847574 0 0 0.000320804359238686 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.His167Pro Rv2752c_p.His167Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 80.2910622977969 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.His223Arg Rv2752c_p.His223Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.His223Tyr Rv2752c_p.His223Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 9.67028206568003 0.541992006917746 476.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.His323Arg Rv2752c_p.His323Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2801 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2339 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.His36Gln Rv2752c_p.His36Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.His371Arg Rv2752c_p.His371Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2956 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2461 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.His371Asp Rv2752c_p.His371Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2901 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.His371fs Rv2752c_p.His371fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3147 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2616 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.His371Tyr Rv2752c_p.His371Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 7 1 16803 30531 0.000416418798334324 0.000167437820935922 0.000857792460925722 0.999967247478055 0.999817528289014 0.999999170778282 0.875 0.473490329124793 0.996840276468748 0 0 0.975 0 0 0.975 0 0 70.7879274408962 1 938.5 4649 False False 12.7189787537939 1.63372483035451 571.646572779703 0 0 0.000219512858481393 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 4 1 11498 23706 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 0.999957818365883 0.999765001636458 0.999998932054057 0.8 0.28358206388191 0.994949236620532 0 0 0.975 0 0 0.975 0 0 80.3119851470932 1 1214.5 3890 False False 0 0 0 0 0 0 0 8.24699947817011 0.815939832795188 405.284913246419 0 0 0.000320776462830572 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.His375Arg Rv2752c_p.His375Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2790 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.His375fs Rv2752c_p.His375fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2818 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2352 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.His375Tyr Rv2752c_p.His375Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.His397Arg Rv2752c_p.His397Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 16 0 16794 30532 0.000951814396192742 0.000544138942285324 0.00154522796648703 1 0.999879187193184 1 1 0.794092785792177 1 NA NA NA NA NA NA NA NA NA NA 2917 4649 False False Inf 7.00986495552168 Inf 0 0 0.000219630483749807 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 12 0 11490 23707 0.0010432968179447 0.000539199208333142 0.00182171963730016 1 0.999844409142079 1 1 0.735351530602948 1 NA NA NA NA NA NA NA NA NA NA 2433 3890 False False 0 0 0 0 0 0 0 Inf 5.7314630344545 Inf 0 0 0.000320999770035263 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.His397Tyr Rv2752c_p.His397Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3056 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2547 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.His491_Gln531del Rv2752c_p.His491_Gln531del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3117 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.His491fs Rv2752c_p.His491fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 70.7668929171829 1 1627.5 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 0 0 0.000219447565534303 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2567 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.His491Tyr Rv2752c_p.His491Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 1 9 16809 30523 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999705227302502 0.999440503684993 0.999865202576615 0.1 0.00252857854446178 0.445016117028195 0 0 0.602364635616474 0 0 0.336267116879942 0 0 2.75113709809334 0.304353972974272 298 4649 False False 0.201763605475902 0.00460699063398853 1.45637661246692 0 0 0.000219434511605659 0.999705227302502 0.999440503684993 0.999865202576615 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 1 8 11501 23699 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999662546927068 0.999335191784523 0.999854300817065 0.111111111111111 0.00280913674659921 0.482496514917337 0 0 0.602364635616474 0 0 0.369416647552819 0 0 3.12209490204246 0.310785526965702 234 3890 False False 0 0 0 0 0 0 0 0.257575428223632 0.00580827991067691 1.92165917942206 0 0 0.000320692802708327 0.999662546927068 0.999335191784523 0.999854300817065 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.His493Arg Rv2752c_p.His493Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 70.7668929171829 1 1627.5 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 0 0 0.000219447565534303 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.His493Pro Rv2752c_p.His493Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 5 4 16805 30528 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 0.999868989912223 0.999664596427238 0.999964303043777 0.555555555555555 0.212008506778868 0.863004337734833 NA NA NA 0 0 0.602364635616474 NA NA NA NA 2836 4649 False False 2.27075275215709 0.488655453172155 11.44624379658 0 0 0.000219486736640675 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 4 3 11498 23704 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 0.99987345509765 0.999630227076139 0.999973902638554 0.571428571428571 0.184051567640083 0.901011721557492 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2369 3890 False False 0 0 0 0 0 0 0 2.74876790166405 0.464911430750807 18.766829223129 0 0 0.000320776462830572 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.His52Asp Rv2752c_p.His52Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.His66fs Rv2752c_p.His66fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2791 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2329 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.His66Tyr Rv2752c_p.His66Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3072 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2558 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.His81Arg Rv2752c_p.His81Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 4 3 16806 30529 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999901742434167 0.999712876815577 0.99997973646933 0.571428571428571 0.184051567640083 0.901011721557492 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.39659924453693 0.556922492050807 776 4649 False False 2.42207148240707 0.409695730236002 16.540132512068 0 0 0.000219473678051534 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 4 3 11498 23704 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 0.99987345509765 0.999630227076139 0.999973902638554 0.571428571428571 0.184051567640083 0.901011721557492 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98998431276417 0.555673309199799 478 3890 False False 0 0 0 0 0 0 0 2.74876790166405 0.464911430750807 18.766829223129 0 0 0.000320776462830572 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.His81Asp Rv2752c_p.His81Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2997 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2497 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.His81Pro Rv2752c_p.His81Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3095 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2579 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.His81Tyr Rv2752c_p.His81Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 3 5 16807 30527 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999836237390279 0.999617874429585 0.999946824656822 0.375 0.0852334141372535 0.755136783633448 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.98237692213128 0.168460489954902 278 4649 False False 1.08979591836734 0.169210020231233 5.60160594690905 0 0 0.000219460621016169 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 3 4 11499 23703 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.999831273463534 0.999568049920357 0.99995402584539 0.428571428571428 0.0989882784425078 0.815948432359917 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12316517643725 0.310812581812229 294.5 3890 False False 0 0 0 0 0 0 0 1.54598225932689 0.226418767059518 9.13992940102341 0 0 0.000320748571273651 0.999831273463534 0.999568049920357 0.99995402584539 1 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.His83Arg Rv2752c_p.His83Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 3 7 16807 30525 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.99977073234639 0.999527678427408 0.999907817703152 0.3 0.0667395111777345 0.652452850059997 0 0 0.707598226178713 0 0 0.409616397225003 0 0 4.39576145195589 0.556927990033432 804 4649 False False 0.778374656818162 0.129888199762363 3.41016225344332 0 0 0.000219460621016169 0.99977073234639 0.999527678427408 0.999907817703152 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 2 4 11500 23703 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999831273463534 0.999568049920357 0.99995402584539 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.841886116991581 0 0 0.602364635616474 0 0 10.9727700633222 1 504 3890 False False 0 0 0 0 0 0 0 1.0305652173913 0.0931903474189042 7.19201282268065 0 0 0.000320720684566658 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.His83Asn Rv2752c_p.His83Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2859 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.His83Pro Rv2752c_p.His83Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 7 0 16803 30532 0.000416418798334324 0.000167437820935922 0.000857792460925722 1 0.999879187193184 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 3173 4649 False False Inf 2.61832748907777 Inf 0 0 0.000219512858481393 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 5 0 11497 23707 0.00043470700747696 0.000141162766530747 0.00101416710312943 1 0.999844409142079 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 2634 3890 False False 0 0 0 0 0 0 0 Inf 1.88913119689894 Inf 0 0 0.000320804359238686 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.His83Tyr Rv2752c_p.His83Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 70.7668929171829 1 1627.5 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 0 0 0.000219447565534303 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 80.2910622977969 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.His86Arg Rv2752c_p.His86Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 1 16807 30531 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999967247478055 0.999817528289014 0.999999170778282 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 70.771098821806 1 1627.5 4649 False False 5.44969358005592 0.437509494081317 285.652299683162 0 0 0.000219460621016169 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2635 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.His86fs Rv2752c_p.His86fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2860 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2386 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.His86Pro Rv2752c_p.His86Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3118 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.His86Tyr Rv2752c_p.His86Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.67117271135833 0.542004252564565 721 4649 False False 0.908144446427509 0.0153974005043644 17.4461131425891 0 0 0.000219434511605659 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.9727417274169 1 1214.5 3890 False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 0 0 0.000320692802708327 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ile121fs Rv2752c_p.Ile121fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ile121Met Rv2752c_p.Ile121Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2845 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2377 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ile165fs Rv2752c_p.Ile165fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2932 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2445 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ile165Ser Rv2752c_p.Ile165Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2909 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2426 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ile165Val Rv2752c_p.Ile165Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ile171fs Rv2752c_p.Ile171fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ile234Arg Rv2752c_p.Ile234Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ile234Val Rv2752c_p.Ile234Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ile248Thr Rv2752c_p.Ile248Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ile249Ser Rv2752c_p.Ile249Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ile24Val Rv2752c_p.Ile24Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2980 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2483 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ile287Val Rv2752c_p.Ile287Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3096 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ile303Ser Rv2752c_p.Ile303Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2957 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2462 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ile358dup Rv2752c_p.Ile358dup 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.75142405620251 0.304356294847217 327.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12235036001139 0.310791984491028 261 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ile42Asn Rv2752c_p.Ile42Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2972 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2475 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ile438Thr Rv2752c_p.Ile438Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ile43fs Rv2752c_p.Ile43fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3148 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ile43Ser Rv2752c_p.Ile43Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3136 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ile43Val Rv2752c_p.Ile43Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ile453Thr Rv2752c_p.Ile453Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3174 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ile460Val Rv2752c_p.Ile460Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ile527fs Rv2752c_p.Ile527fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ile527Met Rv2752c_p.Ile527Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2981 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2484 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ile527Thr Rv2752c_p.Ile527Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2973 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2476 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ile527Val Rv2752c_p.Ile527Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3175 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ile529fs Rv2752c_p.Ile529fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3073 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ile529Ser Rv2752c_p.Ile529Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 3 3 16807 30529 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999901742434167 0.999712876815577 0.99997973646933 0.5 0.118117248757025 0.881882751242974 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.39633757793323 0.556924208491887 781 4649 False False 1.81644552864877 0.243258979140325 13.5672775646283 0 0 0.000219460621016169 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 3 3 11499 23704 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.99987345509765 0.999630227076139 0.999973902638554 0.5 0.118117248757025 0.881882751242974 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98955019326111 0.555672530966789 475.5 3890 False False 0 0 0 0 0 0 0 2.06139664318636 0.276050319534324 15.3984166853777 0 0 0.000320748571273651 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ile551Thr Rv2752c_p.Ile551Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 9.67028206568003 0.541992006917746 476.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 10.9713274274722 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ile556Val Rv2752c_p.Ile556Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3081 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2568 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ile60fs Rv2752c_p.Ile60fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2870 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2395 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ile87Thr Rv2752c_p.Ile87Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ile90fs Rv2752c_p.Ile90fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Leu109Trp Rv2752c_p.Leu109Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 4 16809 30528 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999868989912223 0.999664596427238 0.999964303043777 0.2 0.00505076337946806 0.716417936118089 0 0 0.975 0 0 0.602364635616474 0 0 70.755742229929 1 1627.5 4649 False False 0.454042477244333 0.00922341562850508 4.58878013974823 0 0 0.000219434511605659 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 4 11501 23703 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999831273463534 0.999568049920357 0.99995402584539 0.2 0.00505076337946806 0.716417936118089 0 0 0.975 0 0 0.602364635616474 0 0 80.2809146182867 1 1214.5 3890 False False 0 0 0 0 0 0 0 0.515237805408225 0.0104655802548345 5.20753049950472 0 0 0.000320692802708327 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Leu111Arg Rv2752c_p.Leu111Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Leu111Pro Rv2752c_p.Leu111Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2802 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Leu11fs Rv2752c_p.Leu11fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2941 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Leu154* Rv2752c_p.Leu154* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2803 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2340 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Leu166Arg Rv2752c_p.Leu166Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2942 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2452 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Leu166Pro Rv2752c_p.Leu166Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 1 16807 30531 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999967247478055 0.999817528289014 0.999999170778282 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 70.771098821806 1 1627.5 4649 False False 5.44969358005592 0.437509494081317 285.652299683162 0 0 0.000219460621016169 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Leu16Phe Rv2752c_p.Leu16Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2819 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2353 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Leu16Trp Rv2752c_p.Leu16Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Leu176Ser Rv2752c_p.Leu176Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 5 16809 30527 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999836237390279 0.999617874429585 0.999946824656822 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.841886116991581 0 0 0.521823750104981 0 0 9.67022395468835 0.541991207287615 463 4649 False False 0.363222083407698 0.00768325476784986 3.24674897733262 0 0 0.000219434511605659 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 5 11501 23702 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999789091829417 0.999507879904061 0.999931515258336 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.841886116991581 0 0 0.521823750104981 0 0 10.9713556379464 1 1214.5 3890 False False 0 0 0 0 0 0 0 0.412172854534388 0.00871781959321125 3.68423590106777 0 0 0.000320692802708327 0.999789091829417 0.999507879904061 0.999931515258336 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Leu185Pro Rv2752c_p.Leu185Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 16809 30529 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999901742434167 0.999712876815577 0.99997973646933 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.39581433818102 0.556927644280045 795 4649 False False 0.605409800305391 0.0115361654751757 7.54087213596152 0 0 0.000219434511605659 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 1 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Leu191Phe Rv2752c_p.Leu191Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2974 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2477 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Leu191Pro Rv2752c_p.Leu191Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.67117271135833 0.542004252564565 721 4649 False False 0.908144446427509 0.0153974005043644 17.4461131425891 0 0 0.000219434511605659 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Leu199fs Rv2752c_p.Leu199fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2982 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2485 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Leu199Ser Rv2752c_p.Leu199Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3107 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2588 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Leu200Arg Rv2752c_p.Leu200Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 80.2910622977969 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Leu21Pro Rv2752c_p.Leu21Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3108 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2589 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Leu222Arg Rv2752c_p.Leu222Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2983 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2486 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Leu222Gln Rv2752c_p.Leu222Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Leu222Pro Rv2752c_p.Leu222Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2517 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Leu225His Rv2752c_p.Leu225His 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Leu225Pro Rv2752c_p.Leu225Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 5 1 16805 30531 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 0.999967247478055 0.999817528289014 0.999999170778282 0.833333333333333 0.358765421002325 0.99578925548551 0 0 0.975 0 0 0.975 0 0 70.7795121310531 1 1627.5 4649 False False 9.08390360011901 1.01631102884943 428.726615606949 0 0 0.000219486736640675 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 1 11499 23706 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.999957818365883 0.999765001636458 0.999998932054057 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 80.3050096524922 1 1214.5 3890 False False 0 0 0 0 0 0 0 6.18471171406209 0.496496186771195 324.103527365594 0 0 0.000320748571273651 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Leu279Arg Rv2752c_p.Leu279Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2846 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Leu286Arg Rv2752c_p.Leu286Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2837 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2370 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Leu302_Thr305del Rv2752c_p.Leu302_Thr305del 2 inframe_deletion (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3082 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2569 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Leu315* Rv2752c_p.Leu315* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2998 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2498 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Leu333fs Rv2752c_p.Leu333fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3083 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2570 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Leu333Pro Rv2752c_p.Leu333Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2958 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2463 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Leu336fs Rv2752c_p.Leu336fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Leu355Arg Rv2752c_p.Leu355Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2933 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2446 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Leu37Pro Rv2752c_p.Leu37Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 70.7668929171829 1 1627.5 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 0 0 0.000219447565534303 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 80.2980353694986 1 1214.5 3890 False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 0 0 0.000320720684566658 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Leu37Val Rv2752c_p.Leu37Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2959 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2464 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Leu381Arg Rv2752c_p.Leu381Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2820 4649 False False Inf 1.1990579265185 Inf 0 0 0.000219473678051534 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 11498 23707 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 1 0.999844409142079 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2354 3890 False False 0 0 0 0 0 0 0 Inf 1.3608069907404 Inf 0 0 0.000320776462830572 1 0.999844409142079 1 2 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Leu382Pro Rv2752c_p.Leu382Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2838 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2371 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Leu384Arg Rv2752c_p.Leu384Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2804 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2341 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Leu384His Rv2752c_p.Leu384His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2792 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2330 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Leu384Val Rv2752c_p.Leu384Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Leu403Arg Rv2752c_p.Leu403Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2960 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2465 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Leu403Met Rv2752c_p.Leu403Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3021 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2518 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Leu40fs Rv2752c_p.Leu40fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2847 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Leu41Ser Rv2752c_p.Leu41Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 70.7668929171829 1 1627.5 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 0 0 0.000219447565534303 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 80.2980353694986 1 1214.5 3890 False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 0 0 0.000320720684566658 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Leu41Trp Rv2752c_p.Leu41Trp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2943 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Leu422Phe Rv2752c_p.Leu422Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Leu431Arg Rv2752c_p.Leu431Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2944 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Leu452Ser Rv2752c_p.Leu452Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2961 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2466 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 2 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Leu452Val Rv2752c_p.Leu452Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3166 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2629 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Leu466Pro Rv2752c_p.Leu466Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2984 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2487 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Leu468fs Rv2752c_p.Leu468fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2861 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2387 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Leu468Phe Rv2752c_p.Leu468Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3057 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Leu487Phe Rv2752c_p.Leu487Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 61 3 58 19 62 16791 30470 0.00113027959547888 0.000680635004098699 0.00176451134196716 0.99796934363946 0.997397535651717 0.998442763878106 0.234567901234567 0.147521542642627 0.341820118821052 0.0491803278688524 0.0102593151683207 0.137069221915894 0.0461538461538461 0.00962107884033856 0.129011279898258 0.0938618594936942 0.0188211376287574 0.288322216939822 2.19360292805776e-08 25 4649 True False 0.556106285817479 0.313903840897732 0.94280459696375 0.000178635226866738 3.68403934739342e-05 0.000521958305710038 0.99796934363946 0.997397535651717 0.998442763878106 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 54 3 51 17 55 11485 23652 0.00147800382542166 0.000861220016155565 0.00236537605429428 0.997680010123592 0.99698127124265 0.998251802550623 0.236111111111111 0.143966063645407 0.350900034012924 0.0555555555555555 0.0116067743799413 0.153885033791633 0.0517241379310344 0.0107964780842947 0.143804627275344 0.12114010602064 0.024151089138815 0.374687341781302 2.96359944223456e-06 24 3890 True False 0 0 0 0 0 0 0 0.636536193453912 0.346180048839211 1.11390609030395 0.000261142061281337 5.3857009196092e-05 0.000762976376394945 0.997680010123592 0.99698127124265 0.998251802550623 8 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Leu48Ser Rv2752c_p.Leu48Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Leu492Arg Rv2752c_p.Leu492Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 3 3 16807 30529 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999901742434167 0.999712876815577 0.99997973646933 0.5 0.118117248757025 0.881882751242974 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.39633757793323 0.556924208491887 781 4649 False False 1.81644552864877 0.243258979140325 13.5672775646283 0 0 0.000219460621016169 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 3 2 11499 23705 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.999915636731767 0.999695284447545 0.999989783053538 0.6 0.146632799634673 0.947255049473683 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.9746468441883 1 1214.5 3890 False False 0 0 0 0 0 0 0 3.09222541090529 0.354154889835857 37.0377673791385 0 0 0.000320748571273651 0.999915636731767 0.999695284447545 0.999989783053538 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Leu504fs Rv2752c_p.Leu504fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2478 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 3 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Leu504Pro Rv2752c_p.Leu504Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2839 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2372 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Leu515Arg Rv2752c_p.Leu515Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3149 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2617 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Leu5Phe Rv2752c_p.Leu5Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 2902 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2420 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 1 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Leu5Val Rv2752c_p.Leu5Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3137 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2609 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Leu61Pro Rv2752c_p.Leu61Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 70.7603724184383 1 1627.5 4649 False False 0.908144446427509 0.0153974005043644 17.4461131425891 0 0 0.000219434511605659 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 80.2876797383181 1 1214.5 3890 False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 0 0 0.000320692802708327 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Leu77Arg Rv2752c_p.Leu77Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Leu77Pro Rv2752c_p.Leu77Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2862 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2388 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Leu93Arg Rv2752c_p.Leu93Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 9 4 16801 30528 0.000535395597858417 0.000244845253515427 0.00101610321951737 0.999868989912223 0.999664596427238 0.999964303043777 0.692307692307692 0.385738338249294 0.909079605427903 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.75289810908392 0.304368279620441 365.5 4649 False False 4.08832807570977 1.14079815739485 18.1636973211369 0 0 0.000219538986540545 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 6 3 11496 23704 0.000521648408972352 0.000191459062774625 0.00113506056981396 0.99987345509765 0.999630227076139 0.999973902638554 0.666666666666666 0.29929505620854 0.925145368580308 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.99085277846371 0.555674872518264 483 3890 False False 0 0 0 0 0 0 0 4.12386917188587 0.880479664558533 25.486861327091 0 0 0.000320832260499258 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Leu93fs Rv2752c_p.Leu93fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Leu93Met Rv2752c_p.Leu93Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 70.7668929171829 1 1627.5 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 0 0 0.000219447565534303 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 80.2910622977969 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Leu93Pro Rv2752c_p.Leu93Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2863 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2389 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Leu94Arg Rv2752c_p.Leu94Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Leu94Phe Rv2752c_p.Leu94Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2934 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2447 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Leu94Pro Rv2752c_p.Leu94Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2840 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2373 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Leu96fs Rv2752c_p.Leu96fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Lys106Asn Rv2752c_p.Lys106Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Lys115Glu Rv2752c_p.Lys115Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Lys172Gln Rv2752c_p.Lys172Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 3 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Lys172Glu Rv2752c_p.Lys172Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 6 1 16804 30531 0.000356930398572278 0.000130998068917797 0.000776724091447791 0.999967247478055 0.999817528289014 0.999999170778282 0.857142857142857 0.421276802956804 0.996389703138099 0 0 0.975 0 0 0.975 0 0 70.7837195358556 1 1627.5 4649 False False 10.9013330159485 1.32231137693091 500.206066508325 0 0 0.000219499796783869 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 4 1 11498 23706 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 0.999957818365883 0.999765001636458 0.999998932054057 0.8 0.28358206388191 0.994949236620532 0 0 0.975 0 0 0.975 0 0 80.3119851470932 1 1214.5 3890 False False 0 0 0 0 0 0 0 8.24699947817011 0.815939832795188 405.284913246419 0 0 0.000320776462830572 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Lys172Thr Rv2752c_p.Lys172Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Lys357fs Rv2752c_p.Lys357fs 2 frameshift (see "Genomic_coordinates" sheet) 1 31 0 31 0 32 16810 30500 0 0 0.000219421459229958 0.998951919297786 0.998520742016693 0.999283006561325 0 0 0.108881160679352 0 0 0.11218874692237 0 0 0.108881160679352 0 0 0.22931509623748 1.58014193092313e-06 35 4649 True False 0 0 0.221735574321233 0 0 0.000219421459229958 0.998951919297786 0.998520742016693 0.999283006561325 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 31 0 31 0 32 11502 23675 0 0 0.000320664925697395 0.998650187708272 0.998094997333691 0.999076551872477 0 0 0.108881160679352 0 0 0.11218874692237 0 0 0.108881160679352 0 0 0.260168779855829 7.31370018615487e-06 29 3890 True False 0 0 0 0 0 0 0 0 0 0.251559098069629 0 0 0.000320664925697395 0.998650187708272 0.998094997333691 0.999076551872477 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Lys357Thr Rv2752c_p.Lys357Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 9 16809 30523 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999705227302502 0.999440503684993 0.999865202576615 0.1 0.00252857854446178 0.445016117028195 NA NA NA 0 0 0.336267116879942 NA NA NA NA 3043 4649 False False 0.201763605475902 0.00460699063398853 1.45637661246692 0 0 0.000219434511605659 0.999705227302502 0.999440503684993 0.999865202576615 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 8 11501 23699 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999662546927068 0.999335191784523 0.999854300817065 0.111111111111111 0.00280913674659921 0.482496514917337 NA NA NA 0 0 0.369416647552819 NA NA NA NA 2537 3890 False False 0 0 0 0 0 0 0 0.257575428223632 0.00580827991067691 1.92165917942206 0 0 0.000320692802708327 0.999662546927068 0.999335191784523 0.999854300817065 5 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Lys408Arg Rv2752c_p.Lys408Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Lys408Asn Rv2752c_p.Lys408Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Lys435Glu Rv2752c_p.Lys435Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 12 38 16798 30494 0.000713860797144556 0.000368914962606047 0.00124663876852724 0.99875540416612 0.998292091113034 0.999119104044951 0.24 0.130609916197457 0.381690748104038 NA NA NA 0 0 0.0925127614158782 NA NA NA NA NA NA False True 0.573263734404471 0.272648072534156 1.12100597452918 0 0 0.000219578190293692 0.99875540416612 0.998292091113034 0.999119104044951 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 11 33 11491 23674 0.000956355416449313 0.000477502787107626 0.00171053820723243 0.998608006074155 0.998045673252633 0.99904162771295 0.25 0.131927437933646 0.403380407735858 NA NA NA 0 0 0.105762810074579 NA NA NA NA NA NA False True 0 0 0 0 0 1 0 0.686740347518347 0.313003979558963 1.39356582276485 0 0 0.000320971839633333 0.998608006074155 0.998045673252633 0.99904162771295 3 Not assoc w R Previous WHO guidance 4) Not assoc w R - Interim DOWN from NotAwR to NotAwRI yes Prev. WHO 3 +Rifampicin Rv2752c p.Lys446fs Rv2752c_p.Lys446fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 3150 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 0 0 0.000219447565534303 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 2618 3890 False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 0 0 0.000320720684566658 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Lys502fs Rv2752c_p.Lys502fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3176 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Lys502Thr Rv2752c_p.Lys502Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3109 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2590 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Lys510Gln Rv2752c_p.Lys510Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 7 0 16803 30532 0.000416418798334324 0.000167437820935922 0.000857792460925722 1 0.999879187193184 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 3110 4649 False False Inf 2.61832748907777 Inf 0 0 0.000219512858481393 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 7 0 11495 23707 0.000608589810467744 0.000244718560881119 0.00125352303681455 1 0.999844409142079 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 2591 3890 False False 0 0 0 0 0 0 0 Inf 2.97179240572548 Inf 0 0 0.000320860166613556 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Lys539Thr Rv2752c_p.Lys539Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3151 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2619 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Met1? Rv2752c_p.Met1? 2 start_lost (see "Genomic_coordinates" sheet) 1 2 0 2 2 2 16808 30530 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999934494956111 0.999763393503742 0.99999206693684 0.5 0.067585986488543 0.932414013511457 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.67174719181657 0.54201215115422 740.5 4649 False False 1.8163969538315 0.131636449523742 25.0652602654423 0 0 0.000219447565534303 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.9727417274169 1 1214.5 3890 False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 0 0 0.000320692802708327 0.999915636731767 0.999695284447545 0.999989783053538 3 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Met188Lys Rv2752c_p.Met188Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 3 5 3 5 16807 30527 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999836237390279 0.999617874429585 0.999946824656822 0.375 0.0852334141372535 0.755136783633448 0.375 0.0852334141372535 0.755136783633448 0.375 0.0852334141372535 0.755136783633448 1.08979591836734 0.169210020231233 5.60160594690905 1 1627.5 4649 False False 1.08979591836734 0.169210020231233 5.60160594690905 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12235036001139 0.310791984491028 261 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Met266Thr Rv2752c_p.Met266Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Met270Arg Rv2752c_p.Met270Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2945 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2453 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Met312Ile Rv2752c_p.Met312Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 10 0 10 0 10 16810 30522 0 0 0.000219421459229958 0.999672474780558 0.999397752220648 0.999842928110511 0 0 0.30849710781876 0 0 0.30849710781876 0 0 0.30849710781876 0 0 0.81016282812198 0.0177766362976847 119.5 4649 False False 0 0 0.81016282812198 0 0 0.000219421459229958 0.999672474780558 0.999397752220648 0.999842928110511 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Met312Val Rv2752c_p.Met312Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 16 0 16 1 17 16809 30515 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999443207126948 0.999108669858669 0.999675615241488 0.0555555555555555 0.00140555616736942 0.272943599673368 0 0 0.205907214207822 0 0 0.195064322969093 0 0 0.470835136970416 0.00113536476323284 72 4649 False False 0.106788030221904 0.00255919517247829 0.681652704725612 0 0 0.000219434511605659 0.999443207126948 0.999108669858669 0.999675615241488 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 16 0 16 0 16 11502 23691 0 0 0.000320664925697395 0.999325093854136 0.99890422546949 0.999614185177149 0 0 0.205907214207822 0 0 0.205907214207822 0 0 0.205907214207822 0 0 0.534199663539764 0.00242422393218463 59 3890 False False 0 0 0 0 0 0 0 0 0 0.534199663539764 0 0 0.000320664925697395 0.999325093854136 0.99890422546949 0.999614185177149 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Met318_Arg320del Rv2752c_p.Met318_Arg320del 2 inframe_deletion (see "Genomic_coordinates" sheet) NA 0 0 0 5 0 16805 30532 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 1 0.999879187193184 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 2821 4649 False False Inf 1.66460481015123 Inf 0 0 0.000219486736640675 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2355 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Met318Val Rv2752c_p.Met318Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Met31fs Rv2752c_p.Met31fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2985 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2488 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Met31Ile Rv2752c_p.Met31Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 75 276 16735 30256 0.00446162998215348 0.00351092383353281 0.00558952676003888 0.990960303943403 0.989834245670601 0.991991396147164 0.213675213675213 0.171942601771854 0.260313445725616 NA NA NA 0 0 0.0132765835052668 NA NA NA NA NA NA False True 0.491290058585884 0.375152531233754 0.636729021714364 0 0 0.000220404715623871 0.990960303943403 0.989834245670601 0.991991396147164 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 37 127 11465 23580 0.0032168318553295 0.00226592712135244 0.00443127959617942 0.994642932467203 0.99362934970274 0.995532155360103 0.22560975609756 0.164099311538896 0.297307893011509 NA NA NA 0 0 0.0286285061343876 NA NA NA NA NA NA False True 0 1 1 0 0 1 0 0.599194398563241 0.403474380649974 0.870880097951414 0 0 0.000321699613322993 0.994642932467203 0.99362934970274 0.995532155360103 26 Not assoc w R 5) Not assoc w R No change yes 1 +Rifampicin Rv2752c p.Met394Arg Rv2752c_p.Met394Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 2 16808 30530 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999934494956111 0.999763393503742 0.99999206693684 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2871 4649 False False 1.8163969538315 0.131636449523742 25.0652602654423 0 0 0.000219447565534303 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 2 11500 23705 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999915636731767 0.999695284447545 0.999989783053538 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2396 3890 False False 0 0 0 0 0 0 0 2.06130434782608 0.149383229063395 28.4413197127326 0 0 0.000320720684566658 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Met394fs Rv2752c_p.Met394fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3074 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2559 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Met394Thr Rv2752c_p.Met394Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Met447Thr Rv2752c_p.Met447Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 3 2 16807 30530 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999934494956111 0.999763393503742 0.99999206693684 0.6 0.146632799634673 0.947255049473683 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.67232174050862 0.542020050820051 749.5 4649 False False 2.72475754150056 0.312074221533576 32.6324551811023 0 0 0.000219460621016169 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 2 2 11500 23705 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999915636731767 0.999695284447545 0.999989783053538 0.5 0.067585986488543 0.932414013511457 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.973694203073 1 504 3890 False False 0 0 0 0 0 0 0 2.06130434782608 0.149383229063395 28.4413197127326 0 0 0.000320720684566658 0.999915636731767 0.999695284447545 0.999989783053538 2 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Met550dup Rv2752c_p.Met550dup 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3033 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2528 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Met64Arg Rv2752c_p.Met64Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Met64Ile Rv2752c_p.Met64Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3044 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2538 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Phe107Pro Rv2752c_p.Phe107Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3152 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2620 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Phe107Ser Rv2752c_p.Phe107Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2975 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2479 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Phe107Val Rv2752c_p.Phe107Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2935 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2448 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Phe125Leu Rv2752c_p.Phe125Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3138 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2610 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Phe139fs Rv2752c_p.Phe139fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Phe139Leu Rv2752c_p.Phe139Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Phe139Val Rv2752c_p.Phe139Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Phe144dup Rv2752c_p.Phe144dup 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Phe144Ser Rv2752c_p.Phe144Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3075 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2560 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Phe238Ser Rv2752c_p.Phe238Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 1 16807 30531 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999967247478055 0.999817528289014 0.999999170778282 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 70.771098821806 1 1627.5 4649 False False 5.44969358005592 0.437509494081317 285.652299683162 0 0 0.000219460621016169 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2499 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 1 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Phe349fs Rv2752c_p.Phe349fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3177 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Phe34fs Rv2752c_p.Phe34fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2872 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2397 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Phe383Leu Rv2752c_p.Phe383Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.67117271135833 0.542004252564565 721 4649 False False 0.908144446427509 0.0153974005043644 17.4461131425891 0 0 0.000219434511605659 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.9727417274169 1 1214.5 3890 False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 0 0 0.000320692802708327 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Phe383Val Rv2752c_p.Phe383Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Phe448Leu Rv2752c_p.Phe448Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2864 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Phe472fs Rv2752c_p.Phe472fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2918 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Phe497Cys Rv2752c_p.Phe497Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3034 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Phe49Leu Rv2752c_p.Phe49Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3058 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2548 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Pro101Ala Rv2752c_p.Pro101Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 10 0 10 1 19 16809 30513 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.99937770208306 0.999028374542228 0.999625295739155 0.05 0.0012650894979498 0.248732762772027 0 0 0.30849710781876 0 0 0.176466911806965 0 0 0.809972142791767 0.0177719819572768 115 4649 False False 0.0955409226260368 0.00230339496811282 0.60115165803981 0 0 0.000219434511605659 0.99937770208306 0.999028374542228 0.999625295739155 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 1 18 11501 23689 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999240730585902 0.998800291409329 0.999549948712402 0.0526315789473684 0.00133162880417942 0.260280654195214 0 0 0.30849710781876 0 0 0.185301968137852 0 0 0.919117256433128 0.0366181729287626 111 3890 False False 0 0 0 0 0 0 0 0.114429663121081 0.00275026845772496 0.72492928588382 0 0 0.000320692802708327 0.999240730585902 0.998800291409329 0.999549948712402 5 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Pro101Leu Rv2752c_p.Pro101Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3178 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2636 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Pro10Arg Rv2752c_p.Pro10Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3076 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2561 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Pro123Ala Rv2752c_p.Pro123Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0465715996825058 Inf 0.355075831185839 416 4649 False False Inf 0.0465715996825058 Inf 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0528490600080728 Inf 0.32667783805277 340.5 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Pro123Leu Rv2752c_p.Pro123Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 163 264 16647 30268 0.00969660916121356 0.00827082880653259 0.0112956590590792 0.991353334206734 0.990250331288284 0.99236125335565 0.381733021077283 0.33544279459853 0.429674188878891 NA NA NA 0 0 0.0138758585874989 NA NA NA NA NA NA False True 1.12261650565849 0.916874457602369 1.37115166750746 0 0 0.00022156969826797 0.991353334206734 0.990250331288284 0.99236125335565 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 93 206 11409 23501 0.00808555033907146 0.00653089996717903 0.00989632034691545 0.991310583371999 0.990045829361759 0.99245256745733 0.311036789297658 0.258998845360579 0.366866351584128 NA NA NA 0 0 0.0177478010074704 NA NA NA NA NA NA False True 0 1 1 0 0 1 0 0.929939061905649 0.719230768025513 1.19489565623513 0 0 0.00032327839025998 0.991310583371999 0.990045829361759 0.99245256745733 62 Not assoc w R 5) Not assoc w R No change yes 1 +Rifampicin Rv2752c p.Pro123Ser Rv2752c_p.Pro123Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3059 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2549 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Pro178Leu Rv2752c_p.Pro178Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3179 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2637 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Pro186Ser Rv2752c_p.Pro186Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 70.7603724184383 1 1627.5 4649 False False 0.908144446427509 0.0153974005043644 17.4461131425891 0 0 0.000219434511605659 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Pro209Ala Rv2752c_p.Pro209Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Pro209Ser Rv2752c_p.Pro209Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Pro213Ala Rv2752c_p.Pro213Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Pro213fs Rv2752c_p.Pro213fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3035 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2529 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Pro213Leu Rv2752c_p.Pro213Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3022 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2519 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Pro220Ala Rv2752c_p.Pro220Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2822 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2356 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Pro220fs Rv2752c_p.Pro220fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 4 1 16806 30531 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999967247478055 0.999817528289014 0.999999170778282 0.8 0.28358206388191 0.994949236620532 0 0 0.975 0 0 0.975 0 0 70.7753052263996 1 1627.5 4649 False False 7.26669046769011 0.71899465830523 357.208630433948 0 0 0.000219473678051534 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 4 1 11498 23706 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 0.999957818365883 0.999765001636458 0.999998932054057 0.8 0.28358206388191 0.994949236620532 0 0 0.975 0 0 0.975 0 0 80.3119851470932 1 1214.5 3890 False False 0 0 0 0 0 0 0 8.24699947817011 0.815939832795188 405.284913246419 0 0 0.000320776462830572 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Pro220Leu Rv2752c_p.Pro220Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Pro390Arg Rv2752c_p.Pro390Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2999 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Pro390Leu Rv2752c_p.Pro390Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 64 37 16746 30495 0.00380725758477096 0.0029332496286521 0.00485921805238517 0.998788156688065 0.998330016628398 0.999146611401903 0.633663366336633 0.531931234402262 0.727335002467614 0 0 0.975 0 0 0.0948905874149899 0 0 70.9449514919331 1 1627.5 4649 False False 3.14989299582635 2.0684371090921 4.85981339561301 0 0 0.000220259953600258 0.998788156688065 0.998330016628398 0.999146611401903 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 40 30 11462 23677 0.00347765605981568 0.00248561558726754 0.00473260077937252 0.998734550976504 0.998193981604752 0.999146049059161 0.571428571428571 0.447487106811535 0.689132081896395 NA NA NA 0 0 0.115703308222027 NA NA NA NA 2331 3890 False False 0 0 0 0 0 0 0 2.75426045483627 1.67202667276383 4.5813459784791 0 0 0.000321783799638359 0.998734550976504 0.998193981604752 0.999146049059161 18 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Pro395Ser Rv2752c_p.Pro395Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3045 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2539 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Pro416Leu Rv2752c_p.Pro416Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Pro443Leu Rv2752c_p.Pro443Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 1 5 16809 30527 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999836237390279 0.999617874429585 0.999946824656822 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.98214103142536 0.168452649138924 269 4649 False False 0.363222083407698 0.00768325476784986 3.24674897733262 0 0 0.000219434511605659 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 2.24912710990902 0.180424970179968 177 3890 False False 0 0 0 0 0 0 0 0 0 2.24912710990902 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 1 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Pro486Leu Rv2752c_p.Pro486Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Pro490Arg Rv2752c_p.Pro490Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3180 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2638 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Pro490fs Rv2752c_p.Pro490fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3153 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2621 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Pro50Leu Rv2752c_p.Pro50Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Pro549Gln Rv2752c_p.Pro549Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Pro549Leu Rv2752c_p.Pro549Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Pro549Ser Rv2752c_p.Pro549Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2410 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Pro553Leu Rv2752c_p.Pro553Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Pro553Ser Rv2752c_p.Pro553Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3006 4649 False False 0.908144446427509 0.0153974005043644 17.4461131425891 0 0 0.000219434511605659 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2504 3890 False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 0 0 0.000320692802708327 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Pro55Ser Rv2752c_p.Pro55Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3007 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2505 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Pro62Leu Rv2752c_p.Pro62Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3084 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Pro62Ser Rv2752c_p.Pro62Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Pro62Thr Rv2752c_p.Pro62Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2873 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2398 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Pro6Arg Rv2752c_p.Pro6Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Pro6fs Rv2752c_p.Pro6fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3097 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2580 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Pro7fs Rv2752c_p.Pro7fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 70.7603724184383 1 1627.5 4649 False False 0.908144446427509 0.0153974005043644 17.4461131425891 0 0 0.000219434511605659 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2489 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Pro7Gln Rv2752c_p.Pro7Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Pro8fs Rv2752c_p.Pro8fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.67117271135833 0.542004252564565 721 4649 False False 0.908144446427509 0.0153974005043644 17.4461131425891 0 0 0.000219434511605659 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Pro8Ser Rv2752c_p.Pro8Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Pro91Leu Rv2752c_p.Pro91Leu 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 77 18 16733 30514 0.00458060678167757 0.0036165835579759 0.00572169443720038 0.999410454605004 0.999068423526975 0.999650561796013 0.810526315789473 0.717181290400335 0.883665176081771 NA NA NA 0 0 0.185301968137852 NA NA NA NA 2919 4649 False False 7.8008791675797 4.62171341471949 13.8570334036736 0 0 0.000220431056438049 0.999410454605004 0.999068423526975 0.999650561796013 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 70 14 11432 23693 0.00608589810467744 0.00474723838232396 0.00768299646884707 0.999409457122369 0.999009367705732 0.999677108302285 0.833333333333333 0.736200353091409 0.905776260344176 NA NA NA 0 0 0.231635761650116 NA NA NA NA 2434 3890 False False 0 0 0 0 0 0 0 10.362578726382 5.78112191290531 19.9292093703683 0 0 0.000322628092550751 0.999409457122369 0.999009367705732 0.999677108302285 8 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ser133fs Rv2752c_p.Ser133fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3154 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ser13Tyr Rv2752c_p.Ser13Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ser149Phe Rv2752c_p.Ser149Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 5 16809 30527 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999836237390279 0.999617874429585 0.999946824656822 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.975 0 0 0.521823750104981 0 0 70.7534271354228 1 1627.5 4649 False False 0.363222083407698 0.00768325476784986 3.24674897733262 0 0 0.000219434511605659 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ser189* Rv2752c_p.Ser189* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2805 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2342 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ser216fs Rv2752c_p.Ser216fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2882 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2404 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ser240Cys Rv2752c_p.Ser240Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ser240fs Rv2752c_p.Ser240fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3155 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ser240Phe Rv2752c_p.Ser240Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 1 5 16809 30527 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999836237390279 0.999617874429585 0.999946824656822 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.602364635616474 0 0 0.521823750104981 0 0 2.75149762911492 0.304356889326431 345.5 4649 False False 0.363222083407698 0.00768325476784986 3.24674897733262 0 0 0.000219434511605659 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 4 11501 23703 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999831273463534 0.999568049920357 0.99995402584539 0.2 0.00505076337946806 0.716417936118089 0 0 0.707598226178713 0 0 0.602364635616474 0 0 4.98847166909844 0.555670606021029 460 3890 False False 0 0 0 0 0 0 0 0.515237805408225 0.0104655802548345 5.20753049950472 0 0 0.000320692802708327 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ser240Pro Rv2752c_p.Ser240Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2806 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2343 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ser260* Rv2752c_p.Ser260* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2920 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2435 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ser284fs Rv2752c_p.Ser284fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ser284Pro Rv2752c_p.Ser284Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 3000 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 0 0 0.000219447565534303 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 2500 3890 False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 0 0 0.000320720684566658 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ser313Leu Rv2752c_p.Ser313Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 3046 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2540 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ser313Pro Rv2752c_p.Ser313Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3139 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ser313Trp Rv2752c_p.Ser313Trp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3008 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ser316Leu Rv2752c_p.Ser316Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ser319Leu Rv2752c_p.Ser319Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ser319Pro Rv2752c_p.Ser319Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.67117271135833 0.542004252564565 721 4649 False False 0.908144446427509 0.0153974005043644 17.4461131425891 0 0 0.000219434511605659 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.9727417274169 1 1214.5 3890 False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 0 0 0.000320692802708327 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ser325Arg Rv2752c_p.Ser325Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2823 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ser337Leu Rv2752c_p.Ser337Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 3 16809 30529 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999901742434167 0.999712876815577 0.99997973646933 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 3167 4649 False False 0.605409800305391 0.0115361654751757 7.54087213596152 0 0 0.000219434511605659 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2630 3890 False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 0 0 0.000320692802708327 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ser337Pro Rv2752c_p.Ser337Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2506 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ser337Trp Rv2752c_p.Ser337Trp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2874 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ser338Leu Rv2752c_p.Ser338Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3168 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ser338Pro Rv2752c_p.Ser338Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3023 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2520 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ser339del Rv2752c_p.Ser339del 2 inframe_deletion (see "Genomic_coordinates" sheet) NA 0 0 0 10 0 16800 30532 0.000594883997620464 0.000285305684944214 0.00109373983334496 1 0.999879187193184 1 1 0.691502892181239 1 NA NA NA NA NA NA NA NA NA NA 2825 4649 False False Inf 4.07313735951873 Inf 0 0 0.000219552052902727 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 9 0 11493 23707 0.000782472613458529 0.000357856744032263 0.00148485474620048 1 0.999844409142079 1 1 0.663732883120057 1 NA NA NA NA NA NA NA NA NA NA 2358 3890 False False 0 0 0 0 0 0 0 Inf 4.07050547199104 Inf 0 0 0.000320915993408392 1 0.999844409142079 1 2 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ser339Pro Rv2752c_p.Ser339Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2824 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2357 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ser339* Rv2752c_p.Ser339* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3060 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2550 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ser356Cys Rv2752c_p.Ser356Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2891 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2411 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ser356Pro Rv2752c_p.Ser356Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 9 0 16801 30532 0.000535395597858417 0.000244845253515427 0.00101610321951737 1 0.999879187193184 1 1 0.663732883120057 1 NA NA NA NA NA NA NA NA NA NA 2903 4649 False False Inf 3.58631764003717 Inf 0 0 0.000219538986540545 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 9 0 11493 23707 0.000782472613458529 0.000357856744032263 0.00148485474620048 1 0.999844409142079 1 1 0.663732883120057 1 NA NA NA NA NA NA NA NA NA NA 2421 3890 False False 0 0 0 0 0 0 0 Inf 4.07050547199104 Inf 0 0 0.000320915993408392 1 0.999844409142079 1 3 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ser373Phe Rv2752c_p.Ser373Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2883 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2405 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ser373Tyr Rv2752c_p.Ser373Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2921 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2436 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ser412Arg Rv2752c_p.Ser412Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ser419* Rv2752c_p.Ser419* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3009 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ser428Gly Rv2752c_p.Ser428Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ser437Gly Rv2752c_p.Ser437Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 16809 30529 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999901742434167 0.999712876815577 0.99997973646933 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.39581433818102 0.556927644280045 795 4649 False False 0.605409800305391 0.0115361654751757 7.54087213596152 0 0 0.000219434511605659 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 3 11501 23704 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.99987345509765 0.999630227076139 0.999973902638554 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98868218084989 0.555670981350655 466 3890 False False 0 0 0 0 0 0 0 0.687012723531287 0.0130900577164196 8.55773267307823 0 0 0.000320692802708327 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ser439Cys Rv2752c_p.Ser439Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2936 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2449 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ser439Phe Rv2752c_p.Ser439Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 3 4 16807 30528 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999868989912223 0.999664596427238 0.999964303043777 0.428571428571428 0.0989882784425078 0.815948432359917 0 0 0.841886116991581 0 0 0.602364635616474 0 0 9.67168916111889 0.542011352592427 736 4649 False False 1.36228952222288 0.19952864446048 8.05486976701789 0 0 0.000219460621016169 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 1 11499 23706 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.999957818365883 0.999765001636458 0.999998932054057 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 80.3050096524922 1 1214.5 3890 False False 0 0 0 0 0 0 0 6.18471171406209 0.496496186771195 324.103527365594 0 0 0.000320748571273651 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ser439Pro Rv2752c_p.Ser439Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2910 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2427 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ser470Leu Rv2752c_p.Ser470Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 2922 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2437 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 2 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ser470Pro Rv2752c_p.Ser470Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3085 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2571 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ser494Leu Rv2752c_p.Ser494Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3047 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2541 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ser494Pro Rv2752c_p.Ser494Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2986 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2490 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ser498Ala Rv2752c_p.Ser498Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3010 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2507 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ser498fs Rv2752c_p.Ser498fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2865 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2390 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ser498Pro Rv2752c_p.Ser498Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 31 1 16779 30531 0.00184414039262343 0.00125333722248032 0.00261659758042388 0.999967247478055 0.999817528289014 0.999999170778282 0.96875 0.837829005818488 0.999209131402047 NA NA NA 0 0 0.975 NA NA NA NA 3061 4649 False False 56.4074736277489 9.39889200820985 2272.54391151786 0 0 0.000219826806243681 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 11 0 11491 23707 0.000956355416449313 0.000477502787107626 0.00171053820723243 1 0.999844409142079 1 1 0.715085847081845 1 NA NA NA NA NA NA NA NA NA NA 2551 3890 False False 0 0 0 0 0 0 0 Inf 5.1761760609822 Inf 0 0 0.000320971839633333 1 0.999844409142079 1 6 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Ter559ext*? Rv2752c_p.Ter559ext*? 2 stop_lost (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ter559Glnext*? Rv2752c_p.Ter559Glnext*? 2 stop_lost (see "Genomic_coordinates" sheet) 0 0 0 0 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3086 4649 False False 0.908144446427509 0.0153974005043644 17.4461131425891 0 0 0.000219434511605659 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 2 11501 23705 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999915636731767 0.999695284447545 0.999989783053538 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2572 3890 False False 0 0 0 0 0 0 0 1.03056255977741 0.01747171295278 19.8057300331128 0 0 0.000320692802708327 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Ter559Tyrext*? Rv2752c_p.Ter559Tyrext*? 2 stop_lost (see "Genomic_coordinates" sheet) NA 0 0 0 10 0 16800 30532 0.000594883997620464 0.000285305684944214 0.00109373983334496 1 0.999879187193184 1 1 0.691502892181239 1 NA NA NA NA NA NA NA NA NA NA 2841 4649 False False Inf 4.07313735951873 Inf 0 0 0.000219552052902727 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 9 0 11493 23707 0.000782472613458529 0.000357856744032263 0.00148485474620048 1 0.999844409142079 1 1 0.663732883120057 1 NA NA NA NA NA NA NA NA NA NA 2374 3890 False False 0 0 0 0 0 0 0 Inf 4.07050547199104 Inf 0 0 0.000320915993408392 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Thr122Ile Rv2752c_p.Thr122Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.046570074332069 Inf 0.355083331573055 438.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0528468307335948 Inf 0.326687116564417 358 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Thr12Ala Rv2752c_p.Thr12Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Thr134Ser Rv2752c_p.Thr134Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3111 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2592 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Thr150Pro Rv2752c_p.Thr150Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Thr160Asn Rv2752c_p.Thr160Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2923 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2438 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Thr160Ile Rv2752c_p.Thr160Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Thr160Pro Rv2752c_p.Thr160Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Thr164fs Rv2752c_p.Thr164fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2911 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2428 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Thr183Ile Rv2752c_p.Thr183Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3087 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2573 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Thr183Pro Rv2752c_p.Thr183Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3119 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2597 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Thr204Ala Rv2752c_p.Thr204Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Thr204Arg Rv2752c_p.Thr204Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3077 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2562 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Thr221Ala Rv2752c_p.Thr221Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Thr305Asn Rv2752c_p.Thr305Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2946 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2454 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Thr307Ala Rv2752c_p.Thr307Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2947 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2455 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Thr307Pro Rv2752c_p.Thr307Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2793 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2332 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Thr329Ala Rv2752c_p.Thr329Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Thr329Pro Rv2752c_p.Thr329Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 1 4 5 5 16805 30527 0.000297441998810232 9.65854351254059e-05 0.000693992735539817 0.999836237390279 0.999617874429585 0.999946824656822 0.5 0.187086028447398 0.812913971552601 0.2 0.00505076337946806 0.716417936118089 0.166666666666666 0.00421074451448947 0.641234578997674 0.454135673906575 0.00922530765805129 4.58972213975087 0.661801729655367 930 4649 False False 1.8165426956263 0.417993991073695 7.89433539000939 5.95025586100202e-05 1.50647321873052e-06 0.000331481949204222 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 1 3 4 4 11498 23703 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 0.999831273463534 0.999568049920357 0.99995402584539 0.5 0.157012770487058 0.842987229512941 0.25 0.00630946320970987 0.805879550316756 0.2 0.00505076337946806 0.716417936118089 0.687162984866933 0.0130929193038541 8.55960478855764 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.0614889546008 0.383888088909897 11.0704740677885 8.69640838333768e-05 2.20173755219544e-06 0.00048443655634461 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Thr32Arg Rv2752c_p.Thr32Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2807 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Thr364Ile Rv2752c_p.Thr364Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 3 1 16807 30531 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 0.999967247478055 0.999817528289014 0.999999170778282 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 3048 4649 False False 5.44969358005592 0.437509494081317 285.652299683162 0 0 0.000219460621016169 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Thr364Pro Rv2752c_p.Thr364Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 70.7538526941519 1 1627.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2530 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Thr413Ile Rv2752c_p.Thr413Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Thr461Ile Rv2752c_p.Thr461Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 2 4 16808 30528 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999868989912223 0.999664596427238 0.999964303043777 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.75175148703504 0.304358946073845 356.5 4649 False False 0.90813898143741 0.0821237468238322 6.33854635470206 0 0 0.000219447565534303 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 2 3 11500 23704 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.99987345509765 0.999630227076139 0.999973902638554 0.4 0.0527449505263169 0.853367200365326 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98911614929625 0.555671755017244 473 3890 False False 0 0 0 0 0 0 0 1.37414492753623 0.114734681491877 11.9942804069209 0 0 0.000320720684566658 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Thr461Pro Rv2752c_p.Thr461Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2987 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Thr461Ser Rv2752c_p.Thr461Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Thr476fs Rv2752c_p.Thr476fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3036 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Thr476Pro Rv2752c_p.Thr476Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3120 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2598 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Thr536Met Rv2752c_p.Thr536Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Thr536Ser Rv2752c_p.Thr536Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 4.3952647534881 0.556931257223419 920.5 4649 False False 0 0 1.9820231071276 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 10.9713274274722 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Thr544fs Rv2752c_p.Thr544fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 16808 30531 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999967247478055 0.999817528289014 0.999999170778282 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 70.7668929171829 1 1627.5 4649 False False 3.6329128986197 0.189104318453829 214.057761575796 0 0 0.000219447565534303 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 11500 23706 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 0.999957818365883 0.999765001636458 0.999998932054057 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 80.2980353694986 1 1214.5 3890 False False 0 0 0 0 0 0 0 4.12278260869565 0.214595716751533 242.875597172384 0 0 0.000320720684566658 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Thr554Pro Rv2752c_p.Thr554Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2912 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Thr80Ala Rv2752c_p.Thr80Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 6 16810 30526 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 3156 4649 False False 0 0 1.54251408011679 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 2622 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Thr80Ile Rv2752c_p.Thr80Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 80.2910622977969 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 10 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Trp400Arg Rv2752c_p.Trp400Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 80.2910622977969 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Trp400* Rv2752c_p.Trp400* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 1 0 16 2 16794 30530 0.000951814396192742 0.000544138942285324 0.00154522796648703 0.999934494956111 0.999763393503742 0.99999206693684 0.888888888888888 0.652879561391328 0.986248784335635 1 0.025 1 0.333333333333333 0.00840375865961264 0.905700675949754 Inf 0.0466101407785982 Inf 0.354886423666138 385 4649 False False 14.5432892699773 3.41854542181644 130.612716156442 5.95415302173265e-05 1.50745989291426e-06 0.000331699026023794 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 10 2 11492 23705 0.000869414014953921 0.000416994043678715 0.001598300185227 0.999915636731767 0.999695284447545 0.999989783053538 0.833333333333333 0.515862251314033 0.979137474539907 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2439 3890 False False 0 0 0 0 0 0 0 10.3136964845109 2.19723369471473 96.8419022617611 0 0 0.000320943914091465 0.999915636731767 0.999695284447545 0.999989783053538 9 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Trp540Arg Rv2752c_p.Trp540Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2892 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2412 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Trp540fs Rv2752c_p.Trp540fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2884 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2406 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Trp540Gly Rv2752c_p.Trp540Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3121 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2599 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Trp540* Rv2752c_p.Trp540* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2904 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Tyr143Cys Rv2752c_p.Tyr143Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Tyr143* Rv2752c_p.Tyr143* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2976 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Tyr159fs Rv2752c_p.Tyr159fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3122 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2600 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Tyr159* Rv2752c_p.Tyr159* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Tyr377Asp Rv2752c_p.Tyr377Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Tyr385Asp Rv2752c_p.Tyr385Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 8 1 16802 30531 0.000475907198096371 0.00020548462525215 0.000937510381255989 0.999967247478055 0.999817528289014 0.999999170778282 0.888888888888888 0.517503485082663 0.9971908632534 0 0 0.975 0 0 0.975 0 0 70.7921358462643 1 938.5 4649 False False 14.5368408522794 1.94857414115003 643.047530935858 0 0 0.000219525921733526 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 5 0 11497 23707 0.00043470700747696 0.000141162766530747 0.00101416710312943 1 0.999844409142079 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 2563 3890 False False 0 0 0 0 0 0 0 Inf 1.88913119689894 Inf 0 0 0.000320804359238686 1 0.999844409142079 1 6 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Tyr545Cys Rv2752c_p.Tyr545Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Val102Ala Rv2752c_p.Val102Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 3 16809 30529 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999901742434167 0.999712876815577 0.99997973646933 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2962 4649 False False 0.605409800305391 0.0115361654751757 7.54087213596152 0 0 0.000219434511605659 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 3 11501 23704 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.99987345509765 0.999630227076139 0.999973902638554 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2467 3890 False False 0 0 0 0 0 0 0 0.687012723531287 0.0130900577164196 8.55773267307823 0 0 0.000320692802708327 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Val102Ile Rv2752c_p.Val102Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Val103Asp Rv2752c_p.Val103Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2794 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2333 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Val112_Ala113del Rv2752c_p.Val112_Ala113del 2 inframe_deletion (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2948 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2456 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Val112Ile Rv2752c_p.Val112Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Val124Met Rv2752c_p.Val124Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3062 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2552 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Val128Gly Rv2752c_p.Val128Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2875 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2399 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Val138Ala Rv2752c_p.Val138Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3169 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Val138Leu Rv2752c_p.Val138Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.3955527650214 0.556929363626778 854.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Val146dup Rv2752c_p.Val146dup 2 inframe_insertion (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2842 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Val146fs Rv2752c_p.Val146fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 15 1 16795 30531 0.000892325996430696 0.000499511372123772 0.00147132963433071 0.999967247478055 0.999817528289014 0.999999170778282 0.9375 0.697679261565468 0.998418888277234 0 0 0.975 0 0 0.975 0 0 70.8216087005072 1 1627.5 4649 False False 27.2679368859779 4.19434687579691 1141.6811399976 0 0 0.00021961740805081 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 6 1 11496 23706 0.000521648408972352 0.000191459062774625 0.00113506056981396 0.999957818365883 0.999765001636458 0.999998932054057 0.857142857142857 0.421276802956804 0.996389703138099 0 0 0.975 0 0 0.975 0 0 80.3259397723806 1 1214.5 3890 False False 0 0 0 0 0 0 0 12.3726513569937 1.50072525153826 567.507166587209 0 0 0.000320832260499258 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Val146Leu Rv2752c_p.Val146Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 16810 30526 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.54251408011679 0.0957784996510068 197 4649 False False 0 0 1.54251408011679 0 0 0.000219421459229958 0.999803484868334 0.999572318737888 0.999927879105266 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 11502 23701 0 0 0.000320664925697395 0.9997469101953 0.999449212060655 0.99990711502044 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.75038628279554 0.186840354932931 214 3890 False False 0 0 0 0 0 0 0 0 0 1.75038628279554 0 0 0.000320664925697395 0.9997469101953 0.999449212060655 0.99990711502044 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Val196Ala Rv2752c_p.Val196Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 16810 30528 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.75142405620251 0.304356294847217 327.5 4649 False False 0 0 2.75142405620251 0 0 0.000219421459229958 0.999868989912223 0.999664596427238 0.999964303043777 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 11502 23703 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 3.12235036001139 0.310791984491028 261 3890 False False 0 0 0 0 0 0 0 0 0 3.12235036001139 0 0 0.000320664925697395 0.999831273463534 0.999568049920357 0.99995402584539 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Val211Ala Rv2752c_p.Val211Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Val211Ile Rv2752c_p.Val211Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2826 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2359 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Val211Leu Rv2752c_p.Val211Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2885 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2407 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Val218Leu Rv2752c_p.Val218Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 1 7 1 14 16809 30518 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999541464692781 0.999230775228684 0.999749292529582 0.0666666666666666 0.0016864302413527 0.319484566578303 0.125 0.0031597235312519 0.526509670875206 0.0666666666666666 0.0016864302413527 0.319484566578303 0.259367855655558 0.00575863134311754 2.01923840020243 0.273739892267516 286 4649 False False 0.129683927827779 0.00307091319956987 0.852531396269756 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999541464692781 0.999230775228684 0.999749292529582 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 8 11502 23699 0 0 0.000320664925697395 0.999662546927068 0.999335191784523 0.999854300817065 0 0 0.369416647552819 0 0 0.521823750104981 0 0 0.369416647552819 0 0 2.24884201471042 0.180409432130339 163 3890 False False 0 0 0 0 0 0 0 0 0 1.20731769892417 0 0 0.000320664925697395 0.999662546927068 0.999335191784523 0.999854300817065 1 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Val233Gly Rv2752c_p.Val233Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 16807 30532 0.000178465199286139 3.68053268162106e-05 0.00052146158350611 1 0.999879187193184 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2808 4649 False False Inf 0.750576632084797 Inf 0 0 0.000219460621016169 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 0 11499 23707 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 1 0.999844409142079 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2344 3890 False False 0 0 0 0 0 0 0 Inf 0.851788978516443 Inf 0 0 0.000320748571273651 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Val233Met Rv2752c_p.Val233Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3063 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2553 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Val242Met Rv2752c_p.Val242Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Val245Ile Rv2752c_p.Val245Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.9820231071276 0.168448731581911 252 4649 False False 0 0 1.9820231071276 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 4.98824828790233 0.555670209966509 421.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 1 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Val245Leu Rv2752c_p.Val245Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2893 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2413 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Val259Ala Rv2752c_p.Val259Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Val272Ala Rv2752c_p.Val272Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 17 0 17 2 18 16808 30514 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 0.999410454605004 0.999068423526975 0.999650561796013 0.1 0.0123485271702948 0.316982714019082 0 0 0.195064322969093 0 0 0.185301968137852 0 0 0.440030386483425 0.000679924403485931 65 4649 True False 0.201716114019778 0.0226963968810346 0.842717806922828 0 0 0.000219447565534303 0.999410454605004 0.999068423526975 0.999650561796013 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 12 0 12 0 13 11502 23694 0 0 0.000320664925697395 0.999451638756485 0.999062468123692 0.999707989454911 0 0 0.24705263800047 0 0 0.264648469397051 0 0 0.24705263800047 0 0 0.741528758389462 0.0119673494525516 82 3890 False False 0 0 0 0 0 0 0 0 0 0.676068752178923 0 0 0.000320664925697395 0.999451638756485 0.999062468123692 0.999707989454911 1 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Val281Glu Rv2752c_p.Val281Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Val300Ala Rv2752c_p.Val300Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 111 93 16699 30439 0.00660321237358715 0.0054351092686245 0.00794660214512443 0.99695401545919 0.996269742886194 0.997540814793275 0.544117647058823 0.473108165718982 0.613826286819143 NA NA NA 0 0 0.0388889985342758 NA NA NA NA NA NA False True 2.17560448858247 1.63558535435055 2.89926069484862 0 0 0.000220879815534336 0.99695401545919 0.996269742886194 0.997540814793275 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 101 76 11401 23631 0.0087810815510346 0.00715786423128918 0.0106597187385935 0.996794195807145 0.995989077362525 0.997473384583965 0.570621468926553 0.494209136303066 0.644628142613985 NA NA NA 0 0 0.0473787538669306 NA NA NA NA NA NA False True 0 1 1 0 0 1 0 2.75452638041907 2.0233643441097 3.7631493751206 0 0 0.00032350519569354 0.996794195807145 0.995989077362525 0.997473384583965 11 Not assoc w R 5) Not assoc w R No change yes 1 +Rifampicin Rv2752c p.Val335Met Rv2752c_p.Val335Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.9820231071276 0.168448731581911 252 4649 False False 0 0 1.9820231071276 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Val348fs Rv2752c_p.Val348fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 70 0 16740 30532 0.00416418798334324 0.00324758416539656 0.00525831335367222 1 0.999879187193184 1 1 0.948666202848976 1 NA NA NA NA NA NA NA NA NA NA 2827 4649 False False Inf 33.6997374023596 Inf 0 0 0.000220338891122086 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 70 0 11432 23707 0.00608589810467744 0.00474723838232396 0.00768299646884707 1 0.999844409142079 1 1 0.948666202848976 1 NA NA NA NA NA NA NA NA NA NA 2360 3890 False False 0 0 0 0 0 0 0 Inf 38.2931412236749 Inf 0 0 0.000322628092550751 1 0.999844409142079 1 2 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Val351Ala Rv2752c_p.Val351Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 16 16810 30516 0 0 0.000219421459229958 0.999475959648893 0.999149130429312 0.999700436936355 0 0 0.205907214207822 0 0 0.602364635616474 0 0 0.205907214207822 0 0 2.75034252759744 0.304347573722749 295 4649 False False 0 0 0.470822433885205 0 0 0.000219421459229958 0.999475959648893 0.999149130429312 0.999700436936355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 11 11502 23696 0 0 0.000320664925697395 0.999536002024718 0.999169931473241 0.999768351851939 0 0 0.284914152918154 0 0 0.602364635616474 0 0 0.284914152918154 0 0 3.12142816215882 0.31076869301686 228 3890 False False 0 0 0 0 0 0 0 0 0 0.821023972766749 0 0 0.000320664925697395 0.999536002024718 0.999169931473241 0.999768351851939 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Val370Gly Rv2752c_p.Val370Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 80.2910622977969 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Val372fs Rv2752c_p.Val372fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2963 4649 False False Inf 1.1990579265185 Inf 0 0 0.000219473678051534 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 11498 23707 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 1 0.999844409142079 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2468 3890 False False 0 0 0 0 0 0 0 Inf 1.3608069907404 Inf 0 0 0.000320776462830572 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Val388fs Rv2752c_p.Val388fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2924 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Val388Glu Rv2752c_p.Val388Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2876 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2400 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Val393Leu Rv2752c_p.Val393Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 3037 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2531 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Val393Met Rv2752c_p.Val393Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 3098 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2581 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Val396Gly Rv2752c_p.Val396Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 16810 30529 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 70.7538526941519 1 1627.5 4649 False False 0 0 4.3955527650214 0 0 0.000219421459229958 0.999901742434167 0.999712876815577 0.99997973646933 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 11502 23704 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 80.2773259044493 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 4.98824828790233 0 0 0.000320664925697395 0.99987345509765 0.999630227076139 0.999973902638554 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Val415Ala Rv2752c_p.Val415Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Val415Gly Rv2752c_p.Val415Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 3011 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2508 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Val415Ile Rv2752c_p.Val415Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Val429Phe Rv2752c_p.Val429Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Val432fs Rv2752c_p.Val432fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2988 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Val457Ile Rv2752c_p.Val457Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2905 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2422 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Val473Ala Rv2752c_p.Val473Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3181 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2639 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Val473Gly Rv2752c_p.Val473Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2828 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2361 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Val475Ala Rv2752c_p.Val475Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2989 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2491 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Val477Ile Rv2752c_p.Val477Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2877 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2401 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Val47Ala Rv2752c_p.Val47Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Val47fs Rv2752c_p.Val47fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2848 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2378 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Val47Met Rv2752c_p.Val47Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Val511fs Rv2752c_p.Val511fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2809 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2345 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Val511Gly Rv2752c_p.Val511Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 16809 30530 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999934494956111 0.999763393503742 0.99999206693684 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 70.7603724184383 1 1627.5 4649 False False 0.908144446427509 0.0153974005043644 17.4461131425891 0 0 0.000219434511605659 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 80.2807081709392 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Val523Phe Rv2752c_p.Val523Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2925 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2440 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Val533Ala Rv2752c_p.Val533Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.9820231071276 0.168448731581911 252 4649 False False 0 0 1.9820231071276 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 11502 23702 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 2.24912710990902 0.180424970179968 177 3890 False False 0 0 0 0 0 0 0 0 0 2.24912710990902 0 0 0.000320664925697395 0.999789091829417 0.999507879904061 0.999931515258336 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Val533fs Rv2752c_p.Val533fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 9.6705982991217 0.541996355050968 598.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Val533Gly Rv2752c_p.Val533Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 4 1 16806 30531 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 0.999967247478055 0.999817528289014 0.999999170778282 0.8 0.28358206388191 0.994949236620532 0 0 0.975 0 0 0.975 0 0 70.7753052263996 1 1627.5 4649 False False 7.26669046769011 0.71899465830523 357.208630433948 0 0 0.000219473678051534 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 1 11499 23706 0.000260824204486176 5.37914516051481e-05 0.000762047929932555 0.999957818365883 0.999765001636458 0.999998932054057 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 80.3050096524922 1 1214.5 3890 False False 0 0 0 0 0 0 0 6.18471171406209 0.496496186771195 324.103527365594 0 0 0.000320748571273651 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Val537Phe Rv2752c_p.Val537Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 16810 30530 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 70.756167650906 1 1627.5 4649 False False 0 0 9.6705982991217 0 0 0.000219421459229958 0.999934494956111 0.999763393503742 0.99999206693684 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Val541Gly Rv2752c_p.Val541Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2926 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2441 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Val552Ala Rv2752c_p.Val552Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Val552Gly Rv2752c_p.Val552Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 16809 30531 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 0.999967247478055 0.999817528289014 0.999999170778282 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 70.7626875124415 1 1627.5 4649 False False 1.81634838479386 0.0231376410853604 142.42572627634 0 0 0.000219434511605659 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 11501 23706 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 0.999957818365883 0.999765001636458 0.999998932054057 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 80.2910622977969 1 1214.5 3890 False False 0 0 0 0 0 0 0 2.06121206851578 0.0262561678399451 161.601678830082 0 0 0.000320692802708327 0.999957818365883 0.999765001636458 0.999998932054057 1 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Val555Ala Rv2752c_p.Val555Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2886 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2408 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 1 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Val555Gly Rv2752c_p.Val555Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 16809 30532 5.94883997620464e-05 1.50611474827621e-06 0.000331403082606904 1 0.999879187193184 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 3182 4649 False False Inf 0.0465715996825058 Inf 0 0 0.000219434511605659 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 11501 23707 8.69414014953921e-05 2.20116328638192e-06 0.000484310228674856 1 0.999844409142079 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2640 3890 False False 0 0 0 0 0 0 0 Inf 0.0528490600080728 Inf 0 0 0.000320692802708327 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Val555Ile Rv2752c_p.Val555Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Val558fs Rv2752c_p.Val558fs 2 frameshift (see "Genomic_coordinates" sheet) 1 7 0 7 0 10 16810 30522 0 0 0.000219421459229958 0.999672474780558 0.999397752220648 0.999842928110511 0 0 0.30849710781876 0 0 0.409616397225003 0 0 0.30849710781876 0 0 1.25994683820527 0.0561399108772532 144.5 4649 False False 0 0 0.81016282812198 0 0 0.000219421459229958 0.999672474780558 0.999397752220648 0.999842928110511 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 6 11502 23701 0 0 0.000320664925697395 0.9997469101953 0.999449212060655 0.99990711502044 0 0 0.4592581264399 0 0 0.602364635616474 0 0 0.4592581264399 0 0 3.12208687486085 0.310785326665151 232 3890 False False 0 0 0 0 0 0 0 0 0 1.75038628279554 0 0 0.000320664925697395 0.9997469101953 0.999449212060655 0.99990711502044 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Val558Gly Rv2752c_p.Val558Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 16810 30527 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.9820231071276 0.168448731581911 252 4649 False False 0 0 1.9820231071276 0 0 0.000219421459229958 0.999836237390279 0.999617874429585 0.999946824656822 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 11502 23705 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 10.971789417177 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 10.971789417177 0 0 0.000320664925697395 0.999915636731767 0.999695284447545 0.999989783053538 NA 3) Uncertain significance No change no 1 +Rifampicin Rv2752c p.Val57Gly Rv2752c_p.Val57Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 16808 30532 0.000118976799524092 1.44089671711117e-05 0.000429718322928454 1 0.999879187193184 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 3183 4649 False False Inf 0.341150751115529 Inf 0 0 0.000219447565534303 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 11500 23707 0.000173882802990784 2.10587078620303e-05 0.000627981827233676 1 0.999844409142079 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2641 3890 False False 0 0 0 0 0 0 0 Inf 0.387090251295738 Inf 0 0 0.000320720684566658 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Val67Gly Rv2752c_p.Val67Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 16806 30532 0.000237953599048185 6.48380309854233e-05 0.0006091426203383 1 0.999879187193184 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 3123 4649 False False Inf 1.1990579265185 Inf 0 0 0.000219473678051534 1 0.999879187193184 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 4 0 11498 23707 0.000347765605981568 9.47622920753642e-05 0.000890176504133628 1 0.999844409142079 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2601 3890 False False 0 0 0 0 0 0 0 Inf 1.3608069907404 Inf 0 0 0.000320776462830572 1 0.999844409142079 1 NA 3) Uncertain significance New Uncertain no 0 +Rifampicin Rv2752c p.Val67Ile Rv2752c_p.Val67Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 16810 30531 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 0 0 0.975 0 0 0.975 0 0 0.975 0 0 70.7584826074924 1 1627.5 4649 False False 0 0 70.7584826074924 0 0 0.000219421459229958 0.999967247478055 0.999817528289014 0.999999170778282 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 11502 23706 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 0 0 0.975 0 0 0.975 0 0 0.975 0 0 80.2840904370714 1 1214.5 3890 False False 0 0 0 0 0 0 0 0 0 80.2840904370714 0 0 0.000320664925697395 0.999957818365883 0.999765001636458 0.999998932054057 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA c.1044G>A bacA_c.1044G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 797 632 9571 14976 0.0768711419753086 0.0718146972056725 0.0821667261290025 0.959507944643772 0.956296775711275 0.962546380228862 0.557732680195941 0.531535623704843 0.583691926919151 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.97323930808917 1.76964604373369 2.20082201774309 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 672 512 7064 11362 0.0868665977249224 0.0806824707199557 0.0933640023368354 0.956880579417214 0.953071250691374 0.960463820135828 0.567567567567567 0.538787719692599 0.5960109796772 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 2.11107375424688 1.87153435849865 2.38208997087835 NA NA NA NA NA NA 826 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.1065T>G bacA_c.1065T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 1 10366 15607 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999935930292158 0.99964307871082 0.999998377896754 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.01119043025274 0.156729426968348 177.474331043773 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.1080G>A bacA_c.1080G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.108G>A bacA_c.108G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.1146G>A bacA_c.1146G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.1170G>A bacA_c.1170G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.1182C>T bacA_c.1182C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.1185C>T bacA_c.1185C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.118C>T bacA_c.118C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.1194C>T bacA_c.1194C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.1242G>A bacA_c.1242G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 8 10368 15600 0 0 0.000355731413006942 0.999487442337262 0.998990308225149 0.99977868883794 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.881730950187969 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 5 7736 11869 0 0 0.000476732171726368 0.999578911908371 0.999017596768841 0.999863260157969 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.67480496260254 NA NA NA NA NA NA 17 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.1254G>A bacA_c.1254G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.1290C>T bacA_c.1290C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.129T>C bacA_c.129T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.1317C>T bacA_c.1317C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.1321C>A bacA_c.1321C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.1326G>A bacA_c.1326G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.1335G>A bacA_c.1335G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.1338C>T bacA_c.1338C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.50544998553101 0.0191837380556942 118.074698097101 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.1344G>C bacA_c.1344G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.1348C>T bacA_c.1348C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 10368 15603 0 0 0.000355731413006942 0.999679651460789 0.999252573060182 0.999895975781355 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.64266120859479 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 7736 11870 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.32513012450998 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.1371G>A bacA_c.1371G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 0 10364 15608 0.000385802469135802 0.000105127872737001 0.000987510251175401 1 0.99976368249849 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.993868422549659 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 4 0 7732 11874 0.000517063081695967 0.000140899683864147 0.00132335286075948 1 0.999689379610589 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.01342344657205 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.1374C>T bacA_c.1374C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.1398G>A bacA_c.1398G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.-13G>A bacA_c.-13G>A 2 upstream_gene_variant 2064741 NA 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2193 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1833 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA c.1426C>T bacA_c.1426C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.1428G>A bacA_c.1428G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.1446G>A bacA_c.1446G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.1476G>A bacA_c.1476G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.50544998553101 0.0191837380556942 118.074698097101 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.1506G>A bacA_c.1506G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.1506G>T bacA_c.1506G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.1530G>A bacA_c.1530G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.1533G>A bacA_c.1533G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.752676762805054 0.0127620362920002 14.460605698152 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.153C>T bacA_c.153C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.1542C>T bacA_c.1542C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 21 122 10347 15486 0.00202546296296296 0.00125421710937554 0.00309447762369452 0.99218349564326 0.99067416909511 0.993504761960756 0.146853146853146 0.0932613271946581 0.215679941136029 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.257622784461164 0.15385736531124 0.411912237218938 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 18 107 7718 11767 0.00232678386763185 0.0013795644494434 0.00367483823172597 0.990988714839144 0.989121024912151 0.992609323987571 0.144 0.0876325934237598 0.218003154888471 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.2564777568156 0.146351132274391 0.425461631475709 NA NA NA NA NA NA 404 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.1551G>C bacA_c.1551G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.1563C>A bacA_c.1563C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.1575G>T bacA_c.1575G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.1578G>A bacA_c.1578G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.1581C>T bacA_c.1581C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.1608A>T bacA_c.1608A>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 30 10364 15578 0.000385802469135802 0.000105127872737001 0.000987510251175401 0.998077908764736 0.997257222940417 0.998702808978616 0.117647058823529 0.0330016803364695 0.274503487142355 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.200411681461469 0.0513128856996812 0.568985056042193 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 4 28 7732 11846 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.997641906686878 0.996593688246593 0.998432509782957 0.125 0.0351306531033114 0.289948420190755 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.218867785086098 0.0557359067770275 0.626010271670927 NA NA NA NA NA NA 40 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.1609C>T bacA_c.1609C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.1617C>T bacA_c.1617C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 10368 15603 0 0 0.000355731413006942 0.999679651460789 0.999252573060182 0.999895975781355 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.64266120859479 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 5 7736 11869 0 0 0.000476732171726368 0.999578911908371 0.999017596768841 0.999863260157969 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.67480496260254 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.1621C>T bacA_c.1621C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 6 10367 15602 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999615581752947 0.999163472525571 0.999858912630967 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.250827947654416 0.00545680578940276 2.0680301831463 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 5 7735 11869 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999578911908371 0.999017596768841 0.999863260157969 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.306890756302521 0.00649200912492085 2.74344385104518 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.1623G>A bacA_c.1623G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 96 484 10272 15124 0.00925925925925925 0.00750628355178597 0.011295544350627 0.968990261404408 0.966149841771062 0.971654059596681 0.16551724137931 0.136176324454713 0.19831188389892 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.292036765273808 0.231765516976385 0.364790791986353 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 94 474 7642 11400 0.0121509824198552 0.00983008598967595 0.0148494702589743 0.960080848913592 0.956402919528935 0.963530979504235 0.165492957746478 0.135856283586965 0.198657701901369 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.295833485170228 0.234058971434351 0.370604974016285 NA NA NA NA NA NA 321 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.1653C>G bacA_c.1653C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.1665G>A bacA_c.1665G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.1707C>T bacA_c.1707C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.1737G>C bacA_c.1737G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.17274275317631 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.1746C>T bacA_c.1746C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.17274275317631 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.1782C>T bacA_c.1782C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 6 1 10362 15607 0.000578703703703703 0.000212402724453782 0.00125916554902567 0.999935930292158 0.99964307871082 0.999998377896754 0.857142857142857 0.421276802956804 0.996389703138099 NA NA NA NA NA NA NA NA NA NA NA NA False False 9.03705848291835 1.09610816025756 414.873240547969 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.1794G>A bacA_c.1794G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.6429945931141 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.17274275317631 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.-17G>A bacA_c.-17G>A 2 upstream_gene_variant 2064745 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2235 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1861 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA c.1812C>T bacA_c.1812C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.1821T>C bacA_c.1821T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 1 10366 15607 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999935930292158 0.99964307871082 0.999998377896754 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.01119043025274 0.156729426968348 177.474331043773 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 1 7734 11873 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999915782381674 0.999530859783396 0.999997867796783 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.07033876389966 0.159799628612092 180.959738606129 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.1839G>A bacA_c.1839G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.17274275317631 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.183C>G bacA_c.183C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.1842G>A bacA_c.1842G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.6429945931141 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.71438150990605 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.1857C>T bacA_c.1857C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.1869T>C bacA_c.1869T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 5 0 10363 15608 0.000482253086419753 0.000156604214122162 0.00112505595550109 1 0.99976368249849 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.37979907306709 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 5 0 7731 11874 0.000646328852119958 0.0002098934625097 0.00150766595359595 1 0.999689379610589 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.40693962335604 Inf NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.1896C>T bacA_c.1896C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.-18T>C bacA_c.-18T>C 2 upstream_gene_variant 2064746 NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2257 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1879 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 1 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA c.240G>A bacA_c.240G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.243A>G bacA_c.243A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 5 10366 15603 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999679651460789 0.999252573060182 0.999895975781355 0.285714285714285 0.0366925661760855 0.709579136262657 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.602083735288443 0.0572994001432256 3.67859568857157 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 5 7734 11869 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999578911908371 0.999017596768841 0.999863260157969 0.285714285714285 0.0366925661760855 0.709579136262657 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.61386087406258 0.0584192274045222 3.75047184857656 NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.258G>A bacA_c.258G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.-26T>G bacA_c.-26T>G 2 upstream_gene_variant 2064754 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA c.282C>T bacA_c.282C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.288C>T bacA_c.288C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.291G>A bacA_c.291G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.297G>A bacA_c.297G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.309C>T bacA_c.309C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 11 10364 15597 0.000385802469135802 0.000105127872737001 0.000987510251175401 0.999295233213736 0.998739328260189 0.999648132128855 0.266666666666666 0.0778715462910436 0.551003241036971 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.547243956352408 0.127053504005292 1.84748938892664 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 4 8 7732 11866 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.999326259053394 0.998672895689377 0.999709083033384 0.333333333333333 0.0992460911495833 0.651124493581186 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.767330574236937 0.169034015048489 2.86517783020669 NA NA NA NA NA NA 41 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.312G>A bacA_c.312G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.-32G>T bacA_c.-32G>T 2 upstream_gene_variant 2064760 NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2197 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA c.351C>T bacA_c.351C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.50544998553101 0.0191837380556942 118.074698097101 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.357A>G bacA_c.357A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.-35C>T bacA_c.-35C>T 2 upstream_gene_variant 2064763 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA c.-36G>T bacA_c.-36G>T 2 upstream_gene_variant 2064764 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA c.-40C>T bacA_c.-40C>T 2 upstream_gene_variant 2064768 NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2242 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1866 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 1 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA c.435G>A bacA_c.435G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.438G>A bacA_c.438G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.456C>T bacA_c.456C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.507G>A bacA_c.507G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.17274275317631 NA NA NA NA NA NA 19 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.-50C>T bacA_c.-50C>T 2 upstream_gene_variant 2064778 1 1 0 1 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 58.6540000158548 1 973.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1875 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA c.516C>T bacA_c.516C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.525G>A bacA_c.525G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.558G>A bacA_c.558G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.561C>T bacA_c.561C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.591C>T bacA_c.591C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.17274275317631 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.624C>T bacA_c.624C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.50544998553101 0.0191837380556942 118.074698097101 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.633C>G bacA_c.633C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.-63G>T bacA_c.-63G>T 2 upstream_gene_variant 2064791 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA c.63T>C bacA_c.63T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 8 7 10360 15601 0.000771604938271604 0.00033318123262376 0.00151980017311994 0.999551512045105 0.999076163117038 0.999819666176692 0.533333333333333 0.265861347277396 0.787333270480692 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.72101489244346 0.545167602490433 5.57659256242943 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 8 7 7728 11867 0.00103412616339193 0.000446564649135067 0.00203661849802302 0.999410476671719 0.998785736251934 0.999762949244471 0.533333333333333 0.265861347277396 0.787333270480692 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.75495415557527 0.555826876257836 5.68692951111597 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.651G>A bacA_c.651G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 8 10368 15600 0 0 0.000355731413006942 0.999487442337262 0.998990308225149 0.99977868883794 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.881730950187969 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 7 7736 11867 0 0 0.000476732171726368 0.999410476671719 0.998785736251934 0.999762949244471 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.06467742986826 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.651G>C bacA_c.651G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.663G>A bacA_c.663G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.6429945931141 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.71438150990605 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.-67G>C bacA_c.-67G>C 2 upstream_gene_variant 2064795 1 4 0 4 0 4 10368 15604 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.28044779470556 0.155697794255122 153.5 2512 False False 0 0 2.28044779470556 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.71438150990605 0.283358886007265 193.5 2071 False False 0 0 0 0 0 0 0 0 0 3.71438150990605 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 2 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA c.681T>G bacA_c.681T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 13 10367 15595 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999167093798052 0.998576126182689 0.999556440358575 0.0714285714285714 0.00180678065912538 0.338684489931821 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.115714805113859 0.00272678198231033 0.770665612136054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 13 7735 11861 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.998905170961765 0.998128536682641 0.999416924941029 0.0714285714285714 0.00180678065912538 0.338684489931821 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.117955347819601 0.00277939727411228 0.785674707050631 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.705C>T bacA_c.705C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.708G>A bacA_c.708G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.714C>G bacA_c.714C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.50544998553101 0.0191837380556942 118.074698097101 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.723C>T bacA_c.723C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.72C>A bacA_c.72C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.765G>A bacA_c.765G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.-76G>A bacA_c.-76G>A 2 upstream_gene_variant 2064804 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2249 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1871 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA c.-7G>T bacA_c.-7G>T 2 upstream_gene_variant 2064735 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2188 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA c.837T>C bacA_c.837T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.846C>T bacA_c.846C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.864C>T bacA_c.864C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.17274275317631 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.921G>A bacA_c.921G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.933C>A bacA_c.933C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.939A>G bacA_c.939A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.282736080598822 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.966C>T bacA_c.966C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA c.99T>C bacA_c.99T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin bacA deletion bacA_deletion 2 feature_ablation (see "Genomic_coordinates" sheet) NA 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2212 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1845 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA LoF bacA_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 5 2 3 31 11 10337 15597 0.00298996913580246 0.00203241547020309 0.00424136062971118 0.999295233213736 0.998739328260189 0.999648132128855 0.738095238095238 0.579603312882391 0.861389867911529 0.4 0.0527449505263169 0.853367200365326 0.153846153846153 0.0192066719825284 0.454471055676557 1.00590113185643 0.0839760598494377 8.78380400912568 1 973.5 2512 False False 4.25221842102948 2.07889934889039 9.37819423529881 0.000193442305832285 2.34276192528543e-05 0.000698603582961311 0.999295233213736 0.998739328260189 0.999648132128855 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 15 7 7721 11867 0.00193898655635987 0.00108562946918638 0.00319605008438842 0.999410476671719 0.998785736251934 0.999762949244471 0.681818181818181 0.451275572426229 0.861353478446202 0.5 0.012579117093425 0.987420882906574 0.125 0.0031597235312519 0.526509670875206 1.53697707550835 0.019577454584149 120.547347489081 1 512 2071 False False 0 0 0 0 0 0 0 3.29352230466075 1.26327654810307 9.55022259537236 0.000129500129500129 3.27865403782705e-06 0.00072131499419549 0.999410476671719 0.998785736251934 0.999762949244471 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Ala170Thr bacA_p.Ala170Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2236 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1862 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Ala197Val bacA_p.Ala197Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2170 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1816 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 3 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Ala205Val bacA_p.Ala205Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2250 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1872 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Ala285Thr bacA_p.Ala285Thr 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2177 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1822 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Ala289Ser bacA_p.Ala289Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2189 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1830 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Ala289Val bacA_p.Ala289Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Ala296Val bacA_p.Ala296Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Ala299Thr bacA_p.Ala299Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 10368 15604 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.28044779470556 0.155697794255122 153.5 2512 False False 0 0 2.28044779470556 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 7736 11870 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.32513012450998 0.158605093840654 142 2071 False False 0 0 0 0 0 0 0 0 0 2.32513012450998 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 2 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Ala31Gly bacA_p.Ala31Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2213 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1846 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Ala413Thr bacA_p.Ala413Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Ala438Val bacA_p.Ala438Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Ala474Gly bacA_p.Ala474Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2198 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 0 0 0.000355765720726338 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1836 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 2 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Ala523Thr bacA_p.Ala523Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2194 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Ala610Ser bacA_p.Ala610Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2225 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1856 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Ala630Val bacA_p.Ala630Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 14 0 14 0 17 10368 15591 0 0 0.000355731413006942 0.998910814966683 0.998256680139026 0.999365385605091 0 0 0.195064322969093 0 0 0.231635761650116 0 0 0.195064322969093 0 0 0.453450741182712 0.00139038537427856 46 2512 False False 0 0 0.364520558386886 0 0 0.000355731413006942 0.998910814966683 0.998256680139026 0.999365385605091 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 9 7736 11865 0 0 0.000476732171726368 0.999242041435068 0.998561648359028 0.999653356368186 0 0 0.336267116879942 0 0 0.409616397225003 0 0 0.336267116879942 0 0 1.06449802949186 0.0472635601462793 79.5 2071 False False 0 0 0 0 0 0 0 0 0 0.777323095649869 0 0 0.000476732171726368 0.999242041435068 0.998561648359028 0.999653356368186 4 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Ala98Ser bacA_p.Ala98Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2214 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1847 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Arg14Ser bacA_p.Arg14Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Arg270fs bacA_p.Arg270fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2232 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1859 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Arg270Trp bacA_p.Arg270Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Arg278Cys bacA_p.Arg278Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2243 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Arg326His bacA_p.Arg326His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2199 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Arg329Gln bacA_p.Arg329Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Arg329Leu bacA_p.Arg329Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2171 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1817 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 3 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Arg420fs bacA_p.Arg420fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2253 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1876 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Arg42Gly bacA_p.Arg42Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Arg441Gln bacA_p.Arg441Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Arg452Cys bacA_p.Arg452Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Arg452His bacA_p.Arg452His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Arg508Cys bacA_p.Arg508Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Arg540Gln bacA_p.Arg540Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2244 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1867 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Arg545Ser bacA_p.Arg545Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 10365 15608 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 1 0.99976368249849 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2215 2512 False False Inf 0.622129167636411 Inf 0 0 0.000355834356021348 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Arg628Gln bacA_p.Arg628Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Arg66His bacA_p.Arg66His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Asn208_Thr210del bacA_p.Asn208_Thr210del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Asn335Ser bacA_p.Asn335Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.01513406993295 0.520321755085951 445 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.17205443383047 0.522230766108178 361 2071 False False 0 0 0 0 0 0 0 0 0 3.71438150990605 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 4 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Asp11Asn bacA_p.Asp11Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2172 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1818 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Asp164Ala bacA_p.Asp164Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2180 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1825 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Asp167Asn bacA_p.Asp167Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2259 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1881 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Asp167Tyr bacA_p.Asp167Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2203 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1840 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Asp178Glu bacA_p.Asp178Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2251 2512 False False Inf 0.282736080598822 Inf 0 0 0.000355800035063835 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1873 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Asp295Gly bacA_p.Asp295Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Asp379fs bacA_p.Asp379fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2195 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1834 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Asp379His bacA_p.Asp379His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 5 0 10363 15608 0.000482253086419753 0.000156604214122162 0.00112505595550109 1 0.99976368249849 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 2239 2512 False False Inf 1.37979907306709 Inf 0 0 0.000355903017804084 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Asp423Asn bacA_p.Asp423Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2218 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1850 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Asp423Gly bacA_p.Asp423Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2226 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Asp431Gly bacA_p.Asp431Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.6429945931141 0.280491932584249 243 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.71438150990605 0.283358886007265 193.5 2071 False False 0 0 0 0 0 0 0 0 0 3.71438150990605 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Asp509Asn bacA_p.Asp509Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Asp546Ala bacA_p.Asp546Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 2 8 10366 15600 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999487442337262 0.998990308225149 0.99977868883794 0.2 0.0252107263268333 0.556095462307641 0 0 0.521823750104981 0 0 0.369416647552819 0 0 1.64266231768013 0.16465909339449 195 2512 False False 0.376229982635539 0.0389158944356182 1.88584091729022 0 0 0.000355800035063835 0.999487442337262 0.998990308225149 0.99977868883794 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 7 7736 11867 0 0 0.000476732171726368 0.999410476671719 0.998785736251934 0.999762949244471 0 0 0.409616397225003 0 0 0.602364635616474 0 0 0.409616397225003 0 0 2.32454223697777 0.15856632157164 133 2071 False False 0 0 0 0 0 0 0 0 0 1.06467742986826 0 0 0.000476732171726368 0.999410476671719 0.998785736251934 0.999762949244471 31 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Asp94Asn bacA_p.Asp94Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Cys538Arg bacA_p.Cys538Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2216 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1848 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 2 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Cys538Gly bacA_p.Cys538Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2230 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Gln361Leu bacA_p.Gln361Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Gln361Lys bacA_p.Gln361Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 10368 15603 0 0 0.000355731413006942 0.999679651460789 0.999252573060182 0.999895975781355 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 2.28030160110266 0.155688368476676 145 2512 False False 0 0 1.64266120859479 0 0 0.000355731413006942 0.999679651460789 0.999252573060182 0.999895975781355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 7736 11870 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.71406862449918 0.283346149162266 180.5 2071 False False 0 0 0 0 0 0 0 0 0 2.32513012450998 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 1 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Glu179Lys bacA_p.Glu179Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2254 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1877 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Glu298Asp bacA_p.Glu298Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2258 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1880 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Glu409Ala bacA_p.Glu409Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2185 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1827 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Glu425Lys bacA_p.Glu425Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2200 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1837 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Glu492Gln bacA_p.Glu492Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Glu620Lys bacA_p.Glu620Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.01513406993295 0.520321755085951 445 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.17205443383047 0.522230766108178 361 2071 False False 0 0 0 0 0 0 0 0 0 3.71438150990605 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Gly105Asp bacA_p.Gly105Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2204 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Gly126Trp bacA_p.Gly126Trp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2205 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1841 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Gly168Arg bacA_p.Gly168Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2165 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1811 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Gly168Ser bacA_p.Gly168Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 58.6540000158548 1 973.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 59.801132462225 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 2 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Gly200Asp bacA_p.Gly200Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2233 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1860 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Gly200Ser bacA_p.Gly200Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2178 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1823 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Gly217Arg bacA_p.Gly217Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2181 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Gly243Asp bacA_p.Gly243Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Gly269Glu bacA_p.Gly269Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2237 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Gly336Val bacA_p.Gly336Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2190 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1831 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Gly360Arg bacA_p.Gly360Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Gly368Arg bacA_p.Gly368Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2182 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1826 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Gly403Glu bacA_p.Gly403Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2206 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1842 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Gly488Ser bacA_p.Gly488Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2252 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1874 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Gly554fs bacA_p.Gly554fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 10366 15607 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999935930292158 0.99964307871082 0.999998377896754 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 58.6690617185945 1 973.5 2512 False False 3.01119043025274 0.156729426968348 177.474331043773 0 0 0.000355800035063835 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 59.8138891519084 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 7 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Gly623Ser bacA_p.Gly623Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2240 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1864 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Gly625Ser bacA_p.Gly625Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2173 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1819 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.His159Gln bacA_p.His159Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2245 2512 False False Inf 0.282736080598822 Inf 0 0 0.000355800035063835 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1868 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0 0 0.000476855424503066 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.His159Tyr bacA_p.His159Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2183 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.His485Arg bacA_p.His485Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.His607Gln bacA_p.His607Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Ile143Val bacA_p.Ile143Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Ile264Lys bacA_p.Ile264Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2217 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1849 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Ile264Thr bacA_p.Ile264Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Ile267Ser bacA_p.Ile267Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Ile273Met bacA_p.Ile273Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Ile273Thr bacA_p.Ile273Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 454 35 419 802 640 9566 14968 0.0773533950617283 0.0722821005542092 0.0826635480629949 0.958995386981035 0.955765649713025 0.962052597459147 0.556171983356449 0.530089160257453 0.582025528805556 0.0770925110132158 0.054282798329009 0.105587980089859 0.0518518518518518 0.036378930981336 0.0713785912595237 0.130703560791326 0.0897317020790943 0.184928970376321 1.81272739258629e-51 7 2512 True False 1.96077514112481 1.75930858249549 2.18571762056432 0.00364545359858348 0.00254046590306523 0.00506633102088536 0.958995386981035 0.955765649713025 0.962052597459147 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 363 28 335 674 520 7062 11354 0.0871251292657704 0.080932463170563 0.0936308713209245 0.956206838470608 0.952370565735748 0.959817381340072 0.564489112227805 0.535816653215517 0.592843180546866 0.0771349862258953 0.051865424947159 0.109553205678396 0.0510948905109489 0.0342171377601672 0.0730023502744122 0.134379927042781 0.0878442370757988 0.198091012197824 4.08496998927774e-40 7 2071 True False 0 0 0 0 0 0 0 2.0839041021284 1.84855958538191 2.35011411776412 0.00394922425952045 0.00262578653275022 0.00570270833761842 0.956206838470608 0.952370565735748 0.959817381340072 826 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Ile321Thr bacA_p.Ile321Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2227 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1857 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Ile32Leu bacA_p.Ile32Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2186 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1828 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Ile443Val bacA_p.Ile443Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Ile520fs bacA_p.Ile520fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2234 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Ile603Val bacA_p.Ile603Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 389 1852 9979 13756 0.0375192901234567 0.0339436451095657 0.0413575926819904 0.881342901076371 0.876166335228238 0.88637686849027 0.173583221775992 0.158113441035341 0.189911393604774 NA NA NA 0 0 0.00198985317034647 NA NA NA NA 2166 2512 False True 0.289543462437425 0.25815088373041 0.324183512012287 0 0 0.000369595922909199 0.881342901076371 0.876166335228238 0.88637686849027 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 326 1673 7410 10201 0.0421406411582213 0.037772263409389 0.0468580657552376 0.859103924541014 0.852715996491832 0.865315252007935 0.163081540770385 0.1471394052129 0.180018413149422 NA NA NA 0 0 0.00220251975270751 NA NA NA NA 1812 2071 False True 0 1 1 0 0 0 0 0.268253995142345 0.23660271611466 0.303413400679759 0 0 0.000497700593684396 0.859103924541014 0.852715996491832 0.865315252007935 2744 5) Not assoc w R New NotAwR yes 5 +Streptomycin bacA p.Leu157Pro bacA_p.Leu157Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2231 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Leu175Val bacA_p.Leu175Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2255 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Leu214Val bacA_p.Leu214Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2228 2512 False False Inf 0.282736080598822 Inf 0 0 0.000355800035063835 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1858 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0 0 0.000476855424503066 1 0.999689379610589 1 4 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Leu414Arg bacA_p.Leu414Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 58.6540000158548 1 973.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 59.801132462225 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Leu470fs bacA_p.Leu470fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2248 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1870 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Leu496Val bacA_p.Leu496Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2167 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1813 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Leu529Pro bacA_p.Leu529Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2201 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1838 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Leu551fs bacA_p.Leu551fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 16 3 10352 15605 0.0015432098765432 0.000882326976774945 0.00250486960174422 0.999807790876473 0.99943838714673 0.999960360103688 0.842105263157894 0.604215448733325 0.966173750998235 1 0.025 1 0.25 0.00630946320970987 0.805879550316756 Inf 0.0386482939683613 Inf 0.398836582171199 292 2512 False False 8.03967027305512 2.30023822431234 43.07546618055 9.65903602820438e-05 2.4454532046286e-06 0.000538048236522617 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 5 1 7731 11873 0.000646328852119958 0.0002098934625097 0.00150766595359595 0.999915782381674 0.999530859783396 0.999997867796783 0.833333333333333 0.358765421002325 0.99578925548551 NA NA NA 0 0 0.975 NA NA NA NA 1851 2071 False False 0 0 0 0 0 0 0 7.67882550769628 0.858951237970164 362.566724149337 0 0 0.000477040423209609 0.999915782381674 0.999530859783396 0.999997867796783 18 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Leu585Pro bacA_p.Leu585Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2260 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Leu75fs bacA_p.Leu75fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2207 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1843 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Leu80Val bacA_p.Leu80Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2222 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1854 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Lys549Thr bacA_p.Lys549Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 1 8 10367 15600 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999487442337262 0.998990308225149 0.99977868883794 0.111111111111111 0.00280913674659921 0.482496514917337 0 0 0.602364635616474 0 0 0.369416647552819 0 0 2.28008305484975 0.155674277067132 140 2512 False False 0.188096845760586 0.00424281783599011 1.4034393515988 0 0 0.000355765720726338 0.999487442337262 0.998990308225149 0.99977868883794 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 5 7735 11869 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999578911908371 0.999017596768841 0.999863260157969 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.707598226178713 0 0 0.521823750104981 0 0 3.71423596028016 0.283352956491726 184 2071 False False 0 0 0 0 0 0 0 0.306890756302521 0.00649200912492085 2.74344385104518 0 0 0.000476793790149404 0.999578911908371 0.999017596768841 0.999863260157969 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Lys568Arg bacA_p.Lys568Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Met1? bacA_p.Met1? 2 start_lost (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2220 2512 False False Inf 0.282736080598822 Inf 0 0 0.000355800035063835 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1853 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0 0 0.000476855424503066 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Met123Thr bacA_p.Met123Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Met131Val bacA_p.Met131Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2208 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Met494Ile bacA_p.Met494Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Met494Leu bacA_p.Met494Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2196 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1835 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Met95Ile bacA_p.Met95Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 4 10368 15604 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 58.6464905326305 1 973.5 2512 False False 0 0 2.28044779470556 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.17205443383047 0.522230766108178 361 2071 False False 0 0 0 0 0 0 0 0 0 3.71438150990605 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 7 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Phe121Leu bacA_p.Phe121Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Phe195Leu bacA_p.Phe195Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2174 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1820 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Phe251Ser bacA_p.Phe251Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Phe277Leu bacA_p.Phe277Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2261 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1882 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 3 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Phe384Val bacA_p.Phe384Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Pro184Thr bacA_p.Pro184Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Pro347Leu bacA_p.Pro347Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 4 0 10364 15608 0.000385802469135802 0.000105127872737001 0.000987510251175401 1 0.99976368249849 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2223 2512 False False Inf 0.993868422549659 Inf 0 0 0.000355868683600791 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1855 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0 0 0.000476855424503066 1 0.999689379610589 1 19 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Pro3fs bacA_p.Pro3fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2187 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1829 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Pro437Leu bacA_p.Pro437Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Pro445Ser bacA_p.Pro445Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Pro46Arg bacA_p.Pro46Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2168 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1814 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Pro46Leu bacA_p.Pro46Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2219 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1852 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Pro46Ser bacA_p.Pro46Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Pro503Ala bacA_p.Pro503Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 10368 15604 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.28044779470556 0.155697794255122 153.5 2512 False False 0 0 2.28044779470556 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Pro521His bacA_p.Pro521His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 6 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Pro536Arg bacA_p.Pro536Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2238 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1863 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Pro536Leu bacA_p.Pro536Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2241 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Pro598Ala bacA_p.Pro598Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.50544998553101 0.0191837380556942 118.074698097101 1 973.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.53497091144149 0.0195519049186736 120.390152361053 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Pro609Leu bacA_p.Pro609Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Pro609Ser bacA_p.Pro609Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Pro8Leu bacA_p.Pro8Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 1 3 4 3 10364 15605 0.000385802469135802 0.000105127872737001 0.000987510251175401 0.999807790876473 0.99943838714673 0.999960360103688 0.571428571428571 0.184051567640083 0.901011721557492 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.501897594236459 0.00956430169433416 6.25195199919121 1 973.5 2512 False False 2.00759037694583 0.339557946095546 13.7090540440321 9.64785335262904e-05 2.44262200321851e-06 0.000537425452634802 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 1 3 4 3 7732 11871 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.999747347145022 0.999261820436506 0.999947893876346 0.571428571428571 0.184051567640083 0.901011721557492 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.51176927056389 0.00975199674827699 6.37529432859631 1 806.5 2071 False False 0 0 0 0 0 0 0 2.04707708225556 0.346205885559351 13.9794751519065 0.000129315918789603 3.27399024170944e-06 0.000720289244853199 0.999747347145022 0.999261820436506 0.999947893876346 1 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Ser129Asn bacA_p.Ser129Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Ser207Ala bacA_p.Ser207Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.50544998553101 0.0191837380556942 118.074698097101 1 973.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.53497091144149 0.0195519049186736 120.390152361053 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Ser422Asn bacA_p.Ser422Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Ser422Thr bacA_p.Ser422Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Ser481Ala bacA_p.Ser481Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Ser552fs bacA_p.Ser552fs 2 frameshift (see "Genomic_coordinates" sheet) 1 2 1 1 4 3 10364 15605 0.000385802469135802 0.000105127872737001 0.000987510251175401 0.999807790876473 0.99943838714673 0.999960360103688 0.571428571428571 0.184051567640083 0.901011721557492 0.5 0.012579117093425 0.987420882906574 0.25 0.00630946320970987 0.805879550316756 1.50569278270937 0.0191868302216419 118.093723480598 1 973.5 2512 False False 2.00759037694583 0.339557946095546 13.7090540440321 9.64785335262904e-05 2.44262200321851e-06 0.000537425452634802 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 1 7734 11873 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999915782381674 0.999530859783396 0.999997867796783 0.666666666666666 0.0942993240502461 0.991596241340387 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0393579995238337 Inf 0.394481844145246 247 2071 False False 0 0 0 0 0 0 0 3.07033876389966 0.159799628612092 180.959738606129 0.000129282482223658 3.27314370392442e-06 0.000720103058325324 0.999915782381674 0.999530859783396 0.999997867796783 11 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Ser64Arg bacA_p.Ser64Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 10368 15604 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.28044779470556 0.155697794255122 153.5 2512 False False 0 0 2.28044779470556 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 7736 11870 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.32513012450998 0.158605093840654 142 2071 False False 0 0 0 0 0 0 0 0 0 2.32513012450998 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 2 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Ser64Asn bacA_p.Ser64Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Thr112Ala bacA_p.Thr112Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 10365 15608 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 1 0.99976368249849 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2175 2512 False False Inf 0.622129167636411 Inf 0 0 0.000355834356021348 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1821 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 7 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Thr158Ile bacA_p.Thr158Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Thr210Ala bacA_p.Thr210Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Thr28Pro bacA_p.Thr28Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Thr419Ala bacA_p.Thr419Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2246 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1869 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Thr419Pro bacA_p.Thr419Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Thr45Ala bacA_p.Thr45Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 4 3 10364 15605 0.000385802469135802 0.000105127872737001 0.000987510251175401 0.999807790876473 0.99943838714673 0.999960360103688 0.571428571428571 0.184051567640083 0.901011721557492 0 0 0.975 0 0 0.707598226178713 0 0 58.672860664997 1 973.5 2512 False False 2.00759037694583 0.339557946095546 13.7090540440321 0 0 0.000355868683600791 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 4 2 7732 11872 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.999831564763348 0.99939168785815 0.999979601060482 0.666666666666666 0.222778095503512 0.956728131707258 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1865 2071 False False 0 0 0 0 0 0 0 3.07087428867046 0.439962791152193 33.9588674822466 0 0 0.000476978741026985 0.999831564763348 0.99939168785815 0.999979601060482 7 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Thr467Ser bacA_p.Thr467Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2209 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Thr483Ile bacA_p.Thr483Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.6429945931141 0.280491932584249 243 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Thr506Lys bacA_p.Thr506Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2262 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1883 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Trp122Ser bacA_p.Trp122Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2221 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Trp122* bacA_p.Trp122* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2202 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1839 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Trp153Ser bacA_p.Trp153Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 20 0 20 0 20 10368 15588 0 0 0.000355731413006942 0.998718605843157 0.998021680992693 0.99921712098903 0 0 0.168433470983085 0 0 0.168433470983085 0 0 0.168433470983085 0 0 0.30464585456687 4.22694575729702e-05 34 2512 True False 0 0 0.30464585456687 0 0 0.000355731413006942 0.998718605843157 0.998021680992693 0.99921712098903 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 15 0 15 0 15 7736 11859 0 0 0.000476732171726368 0.998736735725113 0.997917292278642 0.999292793629768 0 0 0.218019360910534 0 0 0.218019360910534 0 0 0.218019360910534 0 0 0.427595288316977 0.000772893837231381 36 2071 True False 0 0 0 0 0 0 0 0 0 0.427595288316977 0 0 0.000476732171726368 0.998736735725113 0.997917292278642 0.999292793629768 104 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Trp627Arg bacA_p.Trp627Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 5 2 10363 15606 0.000482253086419753 0.000156604214122162 0.00112505595550109 0.999871860584315 0.999537193839207 0.999984481345552 0.714285714285714 0.290420863737342 0.963307433823914 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2176 2512 False False 3.76483643732509 0.616187094146839 39.5416182494222 0 0 0.000355903017804084 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Trp627Ser bacA_p.Trp627Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Tyr43Ser bacA_p.Tyr43Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Tyr513Cys bacA_p.Tyr513Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2224 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Val118Ala bacA_p.Val118Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2210 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Val136Met bacA_p.Val136Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2184 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Val192Ile bacA_p.Val192Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Val219Ala bacA_p.Val219Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Val244Met bacA_p.Val244Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 58.6634076928655 1 973.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 59.8138891519084 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Val263Leu bacA_p.Val263Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2191 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1832 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Val291Phe bacA_p.Val291Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2247 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Val320Leu bacA_p.Val320Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Val351fs bacA_p.Val351fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2179 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1824 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Val351Ile bacA_p.Val351Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Val448Ala bacA_p.Val448Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2211 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1844 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Val502Leu bacA_p.Val502Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2229 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Val510Ala bacA_p.Val510Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 1 10365 15607 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999935930292158 0.99964307871082 0.999998377896754 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 2169 2512 False False 4.51722141823444 0.362625225225282 236.854590713406 0 0 0.000355834356021348 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 3 1 7733 11873 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 0.999915782381674 0.999530859783396 0.999997867796783 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 1815 2071 False False 0 0 0 0 0 0 0 4.60610371136686 0.369734697559289 241.512824517625 0 0 0.000476917074793532 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Val510Met bacA_p.Val510Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Val511Ala bacA_p.Val511Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2192 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Val532Met bacA_p.Val532Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Val572Ile bacA_p.Val572Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2256 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1878 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin bacA p.Val632Ile bacA_p.Val632Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid c.102G>C gid_c.102G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 3 10367 15605 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999807790876473 0.99943838714673 0.999960360103688 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.501752355229735 0.00956153582768186 6.25014259670444 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.-11C>G gid_c.-11C>G 1 upstream_gene_variant 4408213 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin gid c.-11C>T gid_c.-11C>T 1 upstream_gene_variant 4408213 1 84 7 77 70 110 10298 15498 0.00675154320987654 0.0052668302409589 0.00852257481504359 0.992952332137365 0.991511806204235 0.994204216379994 0.388888888888888 0.317263619723743 0.464237667583661 0.0833333333333333 0.0341623778539663 0.164189080270795 0.0598290598290598 0.0243901663205423 0.119389158535566 0.136813856176839 0.0532281398669722 0.295812097674935 1.39717171266417e-10 11 2512 True False 0.957696993237874 0.69858299449848 1.30545882330662 0.000679281901989325 0.000273148780410109 0.00139907632126255 0.992952332137365 0.991511806204235 0.994204216379994 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 66 6 60 62 91 7674 11783 0.00801447776628748 0.00615001593522566 0.0102625766933809 0.992336196732356 0.990598771136052 0.993825225439587 0.405228758169934 0.326703673477812 0.487498279331523 0.0909090909090909 0.0340971327712685 0.187442651186473 0.0618556701030927 0.0230359972824477 0.129783660998836 0.153544435757101 0.0541870143964248 0.354475138872011 7.30446322890507e-08 13 2071 True False 0 0 0 0 0 0 0 1.04612692493849 0.744056314889329 1.46251856357739 0.00078125 0.000286757226370394 0.00169967091799336 0.992336196732356 0.990598771136052 0.993825225439587 85 3) Uncertain significance No change no 1 +Streptomycin gid c.123C>G gid_c.123C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.123C>T gid_c.123C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 1 10366 15607 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999935930292158 0.99964307871082 0.999998377896754 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.01119043025274 0.156729426968348 177.474331043773 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.126T>C gid_c.126T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.752676762805054 0.0127620362920002 14.460605698152 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.126T>G gid_c.126T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.132A>G gid_c.132A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.138C>T gid_c.138C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.50544998553101 0.0191837380556942 118.074698097101 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.147A>C gid_c.147A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.148C>T gid_c.148C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.752676762805054 0.0127620362920002 14.460605698152 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 NA NA NA NA NA NA 12 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.-14C>T gid_c.-14C>T 1 upstream_gene_variant 4408216 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin gid c.156C>T gid_c.156C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.162G>C gid_c.162G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.17274275317631 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.174C>G gid_c.174C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.180A>G gid_c.180A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 10368 15604 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.28044779470556 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.71438150990605 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.186T>C gid_c.186T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 7 0 10361 15608 0.000675154320987654 0.000271488767107418 0.00139057803317028 1 0.99976368249849 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 2.17055584412876 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.18C>G gid_c.18C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 6 10367 15602 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999615581752947 0.999163472525571 0.999858912630967 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.250827947654416 0.00545680578940276 2.0680301831463 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 4 7735 11870 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999663129526697 0.999137704464366 0.999908206750254 0.2 0.00505076337946806 0.716417936118089 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.383645765998707 0.00779364023519555 3.87797408017955 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.18C>T gid_c.18C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.752676762805054 0.0127620362920002 14.460605698152 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.192G>C gid_c.192G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.282736080598822 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.195C>A gid_c.195C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.198G>A gid_c.198G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.1A>C gid_c.1A>C 1 initiator_codon_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.-1A>C gid_c.-1A>C 1 upstream_gene_variant 4408203 1 4 2 2 3 2 10365 15606 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999871860584315 0.999537193839207 0.999984481345552 0.6 0.146632799634673 0.947255049473683 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 1.50564399421128 0.109104436422922 20.7716591510574 0.65362265655461 581.5 2512 False False 2.25846599131693 0.258657968313028 27.0476864113414 0.000192919841805729 2.33643418036207e-05 0.000696717215522511 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 2 2 3 2 7733 11872 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 0.999831564763348 0.99939168785815 0.999979601060482 0.6 0.146632799634673 0.947255049473683 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 1.53523858787016 0.111243351068146 21.1810563906676 0.649641371350739 483.5 2071 False False 0 0 0 0 0 0 0 2.30285788180525 0.263724298106321 27.579548092527 0.000258564964447317 3.13149507641486e-05 0.00093371015947595 0.999831564763348 0.99939168785815 0.999979601060482 4 3) Uncertain significance New Uncertain no 0 +Streptomycin gid c.204C>A gid_c.204C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.207T>C gid_c.207T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.50544998553101 0.0191837380556942 118.074698097101 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.21G>A gid_c.21G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.282736080598822 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.21G>C gid_c.21G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.220T>C gid_c.220T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.225G>T gid_c.225G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.228C>T gid_c.228C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.50544998553101 0.0191837380556942 118.074698097101 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.246G>A gid_c.246G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.17274275317631 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.246G>T gid_c.246G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.-24C>A gid_c.-24C>A 1 upstream_gene_variant 4408226 1 1 0 1 0 5 10368 15603 0 0 0.000355731413006942 0.999679651460789 0.999252573060182 0.999895975781355 0 0 0.521823750104981 0 0 0.975 0 0 0.521823750104981 0 0 58.642735790357 1 973.5 2512 False False 0 0 1.64266120859479 0 0 0.000355731413006942 0.999679651460789 0.999252573060182 0.999895975781355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 5 7736 11869 0 0 0.000476732171726368 0.999578911908371 0.999017596768841 0.999863260157969 0 0 0.521823750104981 0 0 0.975 0 0 0.521823750104981 0 0 59.7860363781283 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 1.67480496260254 0 0 0.000476732171726368 0.999578911908371 0.999017596768841 0.999863260157969 NA 3) Uncertain significance No change no 1 +Streptomycin gid c.-24C>T gid_c.-24C>T 1 upstream_gene_variant 4408226 1 5 0 5 0 5 10368 15603 0 0 0.000355731413006942 0.999679651460789 0.999252573060182 0.999895975781355 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.64266120859479 0.164659119890409 198.5 2512 False False 0 0 1.64266120859479 0 0 0.000355731413006942 0.999679651460789 0.999252573060182 0.999895975781355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 7736 11869 0 0 0.000476732171726368 0.999578911908371 0.999017596768841 0.999863260157969 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.67480496260254 0.164218902979591 159.5 2071 False False 0 0 0 0 0 0 0 0 0 1.67480496260254 0 0 0.000476732171726368 0.999578911908371 0.999017596768841 0.999863260157969 4 3) Uncertain significance No change no 1 +Streptomycin gid c.258C>T gid_c.258C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 3 11 10365 15597 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999295233213736 0.998739328260189 0.999648132128855 0.214285714285714 0.0465792878898673 0.507975677048471 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.410393369293514 0.0734979492659496 1.55411541330049 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 3 6 7733 11868 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 0.999494694290045 0.998900489118281 0.999814539856352 0.333333333333333 0.0748546314196918 0.700704943791459 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.767360662097504 0.124161727117722 3.59444067605671 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.-25A>G gid_c.-25A>G 1 upstream_gene_variant 4408227 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Streptomycin gid c.261G>A gid_c.261G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.267T>G gid_c.267T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.270C>G gid_c.270C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.17274275317631 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.273A>G gid_c.273A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.279G>A gid_c.279G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.282A>G gid_c.282A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.285G>C gid_c.285G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 7 10368 15601 0 0 0.000355731413006942 0.999551512045105 0.999076163117038 0.999819666176692 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.04426933597617 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 7 7736 11867 0 0 0.000476732171726368 0.999410476671719 0.998785736251934 0.999762949244471 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.06467742986826 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.288C>G gid_c.288C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.50544998553101 0.0191837380556942 118.074698097101 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.-28C>G gid_c.-28C>G 1 upstream_gene_variant 4408230 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin gid c.291C>G gid_c.291C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 15 1 10353 15607 0.00144675925925925 0.00080995915704588 0.00238508849276012 0.999935930292158 0.99964307871082 0.999998377896754 0.9375 0.697679261565468 0.998418888277234 NA NA NA NA NA NA NA NA NA NA NA NA False False 22.6122862938278 3.47757169663562 947.769322870089 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 5 1 7731 11873 0.000646328852119958 0.0002098934625097 0.00150766595359595 0.999915782381674 0.999530859783396 0.999997867796783 0.833333333333333 0.358765421002325 0.99578925548551 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 7.67882550769628 0.858951237970164 362.566724149337 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.294C>T gid_c.294C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 5 10368 15603 0 0 0.000355731413006942 0.999679651460789 0.999252573060182 0.999895975781355 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.64266120859479 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 5 7736 11869 0 0 0.000476732171726368 0.999578911908371 0.999017596768841 0.999863260157969 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.67480496260254 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.-2T>A gid_c.-2T>A 1 upstream_gene_variant 4408204 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance No change no 1 +Streptomycin gid c.-2T>G gid_c.-2T>G 1 upstream_gene_variant 4408204 1 2 1 1 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.50544998553101 0.0191837380556942 118.074698097101 1 973.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Streptomycin gid c.-30C>T gid_c.-30C>T 1 upstream_gene_variant 4408232 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1667 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1378 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 3 3) Uncertain significance No change no 1 +Streptomycin gid c.30G>C gid_c.30G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.327C>T gid_c.327C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 4 2 10364 15606 0.000385802469135802 0.000105127872737001 0.000987510251175401 0.999871860584315 0.999537193839207 0.999984481345552 0.666666666666666 0.222778095503512 0.956728131707258 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.01157854110382 0.43150328206235 33.3041852472562 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 4 2 7732 11872 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.999831564763348 0.99939168785815 0.999979601060482 0.666666666666666 0.222778095503512 0.956728131707258 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.07087428867046 0.439962791152193 33.9588674822466 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.330G>T gid_c.330G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 366 1744 10002 13864 0.0353009259259259 0.0318316087115962 0.0390342934835175 0.888262429523321 0.883215385222238 0.893164256203038 0.17345971563981 0.157528738085819 0.190303199102799 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.290895032002773 0.258457911441269 0.326778678132806 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 306 1594 7430 10280 0.0395553257497414 0.0353215860804286 0.044140282700352 0.865757116388748 0.859493430417822 0.871840897416709 0.161052631578947 0.144794255695862 0.178364479646613 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 0 0.265605711863633 0.233418521022534 0.301504906979731 NA NA NA NA NA NA 2502 5) Not assoc w R Now listed Silent mutation no 0 +Streptomycin gid c.-33delT gid_c.-33delT 1 upstream_gene_variant 4408234 1 13 4 9 4 11 10364 15597 0.000385802469135802 0.000105127872737001 0.000987510251175401 0.999295233213736 0.998739328260189 0.999648132128855 0.266666666666666 0.0778715462910436 0.551003241036971 0.307692307692307 0.0909203945720966 0.614261661750705 0.266666666666666 0.0778715462910436 0.551003241036971 0.668853724430721 0.150472413603456 2.39722906274131 0.582189501801681 573 2512 False False 0.547243956352408 0.127053504005292 1.84748938892664 0.000385802469135802 0.000105127872737001 0.000987510251175401 0.999295233213736 0.998739328260189 0.999648132128855 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Streptomycin gid c.348G>A gid_c.348G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.-34A>G gid_c.-34A>G 1 upstream_gene_variant 4408236 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid c.357C>T gid_c.357C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.6429945931141 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.71438150990605 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.-35C>T gid_c.-35C>T 1 upstream_gene_variant 4408237 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1609 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1324 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid c.366C>G gid_c.366C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.399T>G gid_c.399T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.402G>T gid_c.402G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.405G>A gid_c.405G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.405G>T gid_c.405G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 41 119 10327 15489 0.00395447530864197 0.00283924933341075 0.00536090779518653 0.992375704766786 0.990883242881547 0.993679965197469 0.25625 0.190590585389426 0.331167920083557 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.516756678462999 0.352831354806892 0.743416452919158 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 7 88 7729 11786 0.000904860392967942 0.000363875741427306 0.00186346392020999 0.992588849587333 0.990877115608237 0.994051920719279 0.0736842105263157 0.0301372189098258 0.145939849233125 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 0 0.121299356614403 0.0473729715420246 0.260811060247347 NA NA NA NA NA NA 155 5) Not assoc w R Now listed Silent mutation no 0 +Streptomycin gid c.414G>A gid_c.414G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.752676762805054 0.0127620362920002 14.460605698152 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.417G>A gid_c.417G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.6429945931141 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.17274275317631 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.417G>C gid_c.417G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.417G>T gid_c.417G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.420C>A gid_c.420C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.420C>G gid_c.420C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.420C>T gid_c.420C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.423G>A gid_c.423G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 58 240 10310 15368 0.00559413580246913 0.00425052134657993 0.00722579175673698 0.984623270117888 0.982567953386227 0.986494948948562 0.194630872483221 0.151236453609093 0.244213795301349 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.360226317491108 0.265312753981783 0.482239296979248 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 56 224 7680 11650 0.00723888314374353 0.00547267327183907 0.00939012257082594 0.981135253495031 0.978524787178665 0.983505890969224 0.2 0.154759310255265 0.251715314152562 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.379231770833333 0.277353975050601 0.511116646274189 NA NA NA NA NA NA 235 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.429C>T gid_c.429C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.438G>A gid_c.438G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.438G>C gid_c.438G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.17274275317631 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.441A>G gid_c.441A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.447C>T gid_c.447C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.454T>C gid_c.454T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.462G>C gid_c.462G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.50544998553101 0.0191837380556942 118.074698097101 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.468C>T gid_c.468C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.17274275317631 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.471G>A gid_c.471G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 3 7 10365 15601 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999551512045105 0.999076163117038 0.999819666176692 0.3 0.0667395111777345 0.652452850059997 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.645069257804424 0.107584929606629 2.8264834997856 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 3 7 7733 11867 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 0.999410476671719 0.998785736251934 0.999762949244471 0.3 0.0667395111777345 0.652452850059997 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.657682289261236 0.109739874070061 2.88202574760339 NA NA NA NA NA NA 20 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.480C>G gid_c.480C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.483C>G gid_c.483C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 75 39 10293 15569 0.00723379629629629 0.00569396740600192 0.0090593025906438 0.997501281394156 0.996585736213267 0.998222581884164 0.657894736842105 0.563182387216833 0.744179791031807 NA NA NA NA NA NA NA NA NA NA NA NA False False 2.9088103191863 1.94839797036115 4.40359880600204 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 15 24 7721 11850 0.00193898655635987 0.00108562946918638 0.00319605008438842 0.997978777160182 0.99699406380332 0.998704548393253 0.384615384615384 0.233639325065819 0.553809431778006 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.959234555109441 0.467585406488237 1.90637185804815 NA NA NA NA NA NA 51 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.492C>G gid_c.492C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.492C>T gid_c.492C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.282736080598822 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.-49T>C gid_c.-49T>C 1 upstream_gene_variant 4408251 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance New Uncertain no 0 +Streptomycin gid c.504C>T gid_c.504C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.507C>T gid_c.507C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.-50A>G gid_c.-50A>G 1 upstream_gene_variant 4408252 0 0 0 0 1 4 10367 15604 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999743721168631 0.999343955596995 0.999930168370675 0.2 0.00505076337946806 0.716417936118089 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1614 2512 False False 0.376290151442075 0.00764455959995544 3.80334957923739 0 0 0.000355765720726338 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 3 7735 11871 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999747347145022 0.999261820436506 0.999947893876346 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1330 2071 False False 0 0 0 0 0 0 0 0.511570782159017 0.0097482170621519 6.37282132403124 0 0 0.000476793790149404 0.999747347145022 0.999261820436506 0.999947893876346 2 3) Uncertain significance No change no 1 +Streptomycin gid c.522C>T gid_c.522C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.525G>C gid_c.525G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 10368 15604 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.28044779470556 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.71438150990605 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.525G>T gid_c.525G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.50544998553101 0.0191837380556942 118.074698097101 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.-52G>T gid_c.-52G>T 1 upstream_gene_variant 4408254 0 0 0 0 4 1 10364 15607 0.000385802469135802 0.000105127872737001 0.000987510251175401 0.999935930292158 0.99964307871082 0.999998377896754 0.8 0.28358206388191 0.994949236620532 NA NA NA 0 0 0.975 NA NA NA NA 1648 2512 False False 6.02354303357776 0.595936886271208 296.214625622934 0 0 0.000355868683600791 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1363 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 2 3) Uncertain significance No change no 1 +Streptomycin gid c.543G>A gid_c.543G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 10368 15604 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.28044779470556 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.71438150990605 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.543G>C gid_c.543G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.549G>A gid_c.549G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 3 10367 15605 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999807790876473 0.99943838714673 0.999960360103688 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.501752355229735 0.00956153582768186 6.25014259670444 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 3 7735 11871 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999747347145022 0.999261820436506 0.999947893876346 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.511570782159017 0.0097482170621519 6.37282132403124 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.-54G>A gid_c.-54G>A 1 upstream_gene_variant 4408256 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin gid c.54T>A gid_c.54T>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.54T>C gid_c.54T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 3 3 10365 15605 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999807790876473 0.99943838714673 0.999960360103688 0.5 0.118117248757025 0.881882751242974 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.50554751567776 0.201606412693291 11.2464963121379 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 2 3 7734 11871 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999747347145022 0.999261820436506 0.999947893876346 0.4 0.0527449505263169 0.853367200365326 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.02327385570209 0.0854221600622099 8.93608975066686 NA NA NA NA NA NA 19 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.555T>C gid_c.555T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.558C>T gid_c.558C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.559A>C gid_c.559A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.6429945931141 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.17274275317631 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.-55G>C gid_c.-55G>C 1 upstream_gene_variant 4408257 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid c.564G>C gid_c.564G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.567G>C gid_c.567G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.567G>T gid_c.567G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 10368 15604 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.28044779470556 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 7736 11870 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.32513012450998 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.-56C>T gid_c.-56C>T 1 upstream_gene_variant 4408258 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Streptomycin gid c.579G>C gid_c.579G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 5 11 10363 15597 0.000482253086419753 0.000156604214122162 0.00112505595550109 0.999295233213736 0.998739328260189 0.999648132128855 0.3125 0.110169954717117 0.586620636451358 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.684120954795469 0.186295413285231 2.13664291963113 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 4 7 7732 11867 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.999410476671719 0.998785736251934 0.999762949244471 0.363636363636363 0.109263443819098 0.692095284988322 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.877023132067105 0.188211137329044 3.45123068737998 NA NA NA NA NA NA 20 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.57T>C gid_c.57T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.588G>A gid_c.588G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.-58A>G gid_c.-58A>G 1 upstream_gene_variant 4408260 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1659 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1370 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid c.58C>A gid_c.58C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.597C>G gid_c.597C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.-59G>A gid_c.-59G>A 1 upstream_gene_variant 4408261 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin gid c.603C>T gid_c.603C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.609G>A gid_c.609G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.50544998553101 0.0191837380556942 118.074698097101 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.-60A>C gid_c.-60A>C 1 upstream_gene_variant 4408262 0 0 0 0 2 2 10366 15606 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999871860584315 0.999537193839207 0.999984481345552 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1640 2512 False False 1.50549874590005 0.10909391082996 20.7696540777406 0 0 0.000355800035063835 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 2 7734 11872 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999831564763348 0.99939168785815 0.999979601060482 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1352 2071 False False 0 0 0 0 0 0 0 1.53504008275148 0.111228967362952 21.1783159842378 0 0 0.000476855424503066 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance No change no 1 +Streptomycin gid c.-60A>G gid_c.-60A>G 1 upstream_gene_variant 4408262 0 0 0 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1557 2512 False False Inf 0.282736080598822 Inf 0 0 0.000355800035063835 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1280 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0 0 0.000476855424503066 1 0.999689379610589 1 2 3) Uncertain significance No change no 1 +Streptomycin gid c.60G>A gid_c.60G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.612C>T gid_c.612C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 3 1 10365 15607 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999935930292158 0.99964307871082 0.999998377896754 0.75 0.194120449683243 0.99369053679029 NA NA NA NA NA NA NA NA NA NA NA NA False False 4.51722141823444 0.362625225225282 236.854590713406 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.615A>G gid_c.615A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 6224 6745 4144 8863 0.600308641975308 0.59080465194909 0.60975625684395 0.567849820604818 0.560034172526735 0.575640169865892 0.479913640218983 0.471282075566832 0.488554222487582 NA NA NA NA NA NA NA NA NA NA NA NA False True 1.97355226665827 1.87589940415225 2.07640044879799 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 4830 5383 2906 6491 0.62435367114788 0.613451984225317 0.635161588206088 0.546656560552467 0.537649857655259 0.555640379391311 0.472926662097326 0.463203722722548 0.482665046850804 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 0 2.00418935040457 1.88944243850223 2.12595325971841 NA NA NA NA NA NA 14938 5) Not assoc w R Now listed Silent mutation no 0 +Streptomycin gid c.621T>C gid_c.621T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.752676762805054 0.0127620362920002 14.460605698152 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.627G>A gid_c.627G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.-63_-62delTC gid_c.-63_-62delTC 1 upstream_gene_variant 4408263 1 3 0 3 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.6429945931141 0.280491932584249 243 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.71438150990605 0.283358886007265 193.5 2071 False False 0 0 0 0 0 0 0 0 0 3.71438150990605 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid c.633C>T gid_c.633C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.636C>G gid_c.636C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.63G>A gid_c.63G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.63G>C gid_c.63G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.645G>A gid_c.645G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 10365 15608 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 1 0.99976368249849 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.622129167636411 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.648A>G gid_c.648A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.17274275317631 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.-64C>A gid_c.-64C>A 1 upstream_gene_variant 4408266 1 1 0 1 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 58.6596525903968 1 973.5 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 0 0 0.000355765720726338 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 59.8088564761233 1 806.5 2071 False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 0 0 0.000476793790149404 0.999831564763348 0.99939168785815 0.999979601060482 3 3) Uncertain significance No change no 1 +Streptomycin gid c.-65T>C gid_c.-65T>C 1 upstream_gene_variant 4408267 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1649 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1364 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin gid c.-68G>C gid_c.-68G>C 1 upstream_gene_variant 4408270 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid c.69C>G gid_c.69C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.17274275317631 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.-6T>C gid_c.-6T>C 1 upstream_gene_variant 4408208 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 1 3) Uncertain significance New Uncertain no 0 +Streptomycin gid c.-71C>A gid_c.-71C>A 1 upstream_gene_variant 4408273 0 0 0 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1560 2512 False False Inf 0.282736080598822 Inf 0 0 0.000355800035063835 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1281 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0 0 0.000476855424503066 1 0.999689379610589 1 2 3) Uncertain significance New Uncertain no 0 +Streptomycin gid c.-71C>T gid_c.-71C>T 1 upstream_gene_variant 4408273 1 3 0 3 0 4 10368 15604 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.64276114479861 0.280482632628927 227 2512 False False 0 0 2.28044779470556 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 59.801132462225 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 2 3) Uncertain significance No change no 1 +Streptomycin gid c.-72G>C gid_c.-72G>C 1 upstream_gene_variant 4408274 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1621 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1335 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance No change no 1 +Streptomycin gid c.-73G>A gid_c.-73G>A 1 upstream_gene_variant 4408275 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1681 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1391 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance No change no 1 +Streptomycin gid c.-73G>C gid_c.-73G>C 1 upstream_gene_variant 4408275 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1550 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid c.-79C>A gid_c.-79C>A 1 upstream_gene_variant 4408281 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Streptomycin gid c.-79C>G gid_c.-79C>G 1 upstream_gene_variant 4408281 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid c.-79C>T gid_c.-79C>T 1 upstream_gene_variant 4408281 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin gid c.-7G>A gid_c.-7G>A 1 upstream_gene_variant 4408209 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 2 3) Uncertain significance No change no 1 +Streptomycin gid c.-7G>C gid_c.-7G>C 1 upstream_gene_variant 4408209 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1610 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1325 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid c.84A>G gid_c.84A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.6429945931141 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.71438150990605 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.87C>T gid_c.87C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.-8A>C gid_c.-8A>C 1 upstream_gene_variant 4408210 1 1 0 1 0 4 10368 15604 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 58.6464905326305 1 973.5 2512 False False 0 0 2.28044779470556 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 4 7736 11870 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 59.7910684069526 1 512 2071 False False 0 0 0 0 0 0 0 0 0 2.32513012450998 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 3 3) Uncertain significance No change no 1 +Streptomycin gid c.99G>C gid_c.99G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.-9G>A gid_c.-9G>A 1 upstream_gene_variant 4408211 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance No change no 1 +Streptomycin gid c.9G>C gid_c.9G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.17274275317631 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin gid c.-9G>C gid_c.-9G>C 1 upstream_gene_variant 4408211 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin gid LoF gid_LoF 1 LoF (see "Genomic_coordinates" sheet) 1 881 533 348 938 577 9430 15031 0.0904706790123456 0.0850164596612528 0.0961561502287713 0.963031778575089 0.959952038934744 0.965937356094822 0.619141914191419 0.594147738206178 0.643673212405081 0.604994324631101 0.571839249017416 0.637444753954084 0.48018018018018 0.450424503041196 0.510041164370484 2.44131684157921 2.12328713999294 2.80920210894083 4.35362566969914e-38 8 2512 True False 2.59121355752778 2.32572165715754 2.88846888124666 0.0534979423868312 0.0491602340153403 0.0580989206979036 0.963031778575089 0.959952038934744 0.965937356094822 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 565 346 219 669 407 7067 11467 0.0864788004136504 0.0803075133212662 0.0929636676457226 0.965723429341418 0.962292599445197 0.968923396768935 0.62174721189591 0.592005203008669 0.650821333220502 0.612389380530973 0.570828489048967 0.652768599006217 0.45949535192563 0.42345488361277 0.49585421148143 2.56357899892289 2.15231078975835 3.05857677419418 9.49403314158897e-28 9 2071 True False 0 0 0 0 0 0 0 2.66714378940217 2.34572010853211 3.03508608986885 0.0466747605557803 0.0419845186769262 0.0517254677510896 0.965723429341418 0.962292599445197 0.968923396768935 NA 1) Assoc w R UP from AwRI to AwR yes 4 +Streptomycin gid p.Ala10Gly gid_p.Ala10Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.752676762805054 0.0127620362920002 14.460605698152 1 1332 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.767420814479638 0.0130114906060525 14.7444541307454 1 806.5 2071 False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 1 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Ala10Pro gid_p.Ala10Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 14 1 13 7 25 10361 15583 0.000675154320987654 0.000271488767107418 0.00139057803317028 0.998398257303946 0.997636413671316 0.998963176712956 0.21875 0.0927715322847193 0.399728263712107 0.0714285714285714 0.00180678065912538 0.338684489931821 0.0384615384615384 0.00097328789333503 0.196369646762539 0.115692723452592 0.00272626240858645 0.770518718340598 0.0120396960326926 70 2512 False False 0.421121513367435 0.153730841889387 1.00201869982154 9.65064659332175e-05 2.44332918880599e-06 0.000537581013405577 0.998398257303946 0.997636413671316 0.998963176712956 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 1 9 5 18 7731 11856 0.000646328852119958 0.0002098934625097 0.00150766595359595 0.998484082870136 0.997605251464505 0.999101331744648 0.217391304347826 0.0746034076488037 0.437030726236814 0.1 0.00252857854446178 0.445016117028195 0.0526315789473684 0.00133162880417942 0.260280654195214 0.170396240244901 0.00389124965913165 1.23017819476079 0.100486723027873 113 2071 False False 0 0 0 0 0 0 0 0.425990600612253 0.123586579303875 1.19118841834865 0.000129332643559234 3.27441367482914e-06 0.000720382374226452 0.998484082870136 0.997605251464505 0.999101331744648 110 3) Uncertain significance No change no 1 +Streptomycin gid p.Ala10Val gid_p.Ala10Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 2 7 10366 15601 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999551512045105 0.999076163117038 0.999819666176692 0.222222222222222 0.0281449734778982 0.600093573716312 0 0 0.707598226178713 0 0 0.409616397225003 0 0 3.64276361181698 0.280482725968121 229 2512 False False 0.430004685648135 0.0435795940165012 2.25913666217328 0 0 0.000355800035063835 0.999551512045105 0.999076163117038 0.999819666176692 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 6 7735 11868 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999494694290045 0.998900489118281 0.999814539856352 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.707598226178713 0 0 0.4592581264399 0 0 3.71392303442799 0.2833402185253 177 2071 False False 0 0 0 0 0 0 0 0.255720749838396 0.00556297279916227 2.10858771426871 0 0 0.000476793790149404 0.999494694290045 0.998900489118281 0.999814539856352 6 3) Uncertain significance No change no 1 +Streptomycin gid p.Ala111Val gid_p.Ala111Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Ala119_Glu120insAspGluIleValArgGlyArgAla gid_p.Ala119_Glu120insAspGluIleValArgGlyArgAla 1 inframe_insertion (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1589 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1309 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Streptomycin gid p.Ala119Asp gid_p.Ala119Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 12 6 6 8 6 10360 15602 0.000771604938271604 0.00033318123262376 0.00151980017311994 0.999615581752947 0.999163472525571 0.999858912630967 0.571428571428571 0.288609400038307 0.823388910017882 0.5 0.210944638239296 0.789055361760703 0.5 0.210944638239296 0.789055361760703 1.50598455598455 0.402480209832499 5.63424091357415 0.559575561617549 564 2512 False False 2.0079794079794 0.610786281740427 7.02280188964479 0.000578815357900829 0.000212443710639651 0.00125940840774178 0.999615581752947 0.999163472525571 0.999858912630967 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 4 4 6 4 7730 11870 0.00077559462254395 0.000284681048736677 0.00168737281383633 0.999663129526697 0.999137704464366 0.999908206750254 0.6 0.262378076606945 0.878447741880172 0.5 0.157012770487058 0.842987229512941 0.5 0.157012770487058 0.842987229512941 1.53557567917205 0.285916743618921 8.24711257313841 0.720098429511551 500 2071 False False 0 0 0 0 0 0 0 2.30336351875808 0.545992298099125 11.1018843698377 0.000517196793379881 0.000140936124797366 0.00132369493958413 0.999663129526697 0.999137704464366 0.999908206750254 27 3) Uncertain significance No change no 1 +Streptomycin gid p.Ala119fs gid_p.Ala119fs 1 frameshift (see "Genomic_coordinates" sheet) 1 6 4 2 8 4 10360 15604 0.000771604938271604 0.00033318123262376 0.00151980017311994 0.999743721168631 0.999343955596995 0.999930168370675 0.666666666666666 0.348875506418814 0.900753908850416 0.666666666666666 0.222778095503512 0.956728131707258 0.5 0.157012770487058 0.842987229512941 3.01235521235521 0.431614529472585 33.3127394751457 0.224969056160177 209 2512 False False 3.01235521235521 0.806734748419887 13.6706140578425 0.000385951370127364 0.000105168450723381 0.000987891267335943 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 4 2 8 4 7728 11870 0.00103412616339193 0.000446564649135067 0.00203661849802302 0.999663129526697 0.999137704464366 0.999908206750254 0.666666666666666 0.348875506418814 0.900753908850416 0.666666666666666 0.222778095503512 0.956728131707258 0.5 0.157012770487058 0.842987229512941 3.07194616977225 0.440116295424424 33.970684207954 0.220827644278935 167 2071 False False 0 0 0 0 0 0 0 3.07194616977225 0.822597400987123 13.9418112652307 0.000517330574236937 0.000140972584584923 0.00132403719530516 0.999663129526697 0.999137704464366 0.999908206750254 7 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Ala119Thr gid_p.Ala119Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 67 4 63 59 86 10309 15522 0.00569058641975308 0.00433467710769235 0.00733438157642729 0.994490005125576 0.993199610573446 0.99559042248241 0.406896551724137 0.326150136362563 0.491527545020318 0.0597014925373134 0.0165044043203047 0.145863231873139 0.0444444444444444 0.0122405278500113 0.109900826878013 0.0955983906803579 0.0252554960551115 0.257289547321232 3.17585675185043e-10 12 2512 True False 1.03296284348514 0.728068777036311 1.45694625035952 0.0003878599825463 0.000105688579474618 0.000992775123383699 0.994490005125576 0.993199610573446 0.99559042248241 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 51 3 48 29 65 7707 11809 0.00374870734229576 0.00251196196754825 0.00537936614861958 0.994525854808826 0.993028000636271 0.99577270469628 0.308510638297872 0.217293149608887 0.412182766656967 0.0588235294117647 0.01229908825524 0.16242221807205 0.0441176470588235 0.00919219520278738 0.123562624331778 0.0957652134423251 0.0190673688380166 0.29731706052476 6.38374023332178e-08 12 2071 True False 0 0 0 0 0 0 0 0.683616292880598 0.424977453703146 1.07562018347101 0.000389105058365758 8.02500067906597e-05 0.00113670486838784 0.994525854808826 0.993028000636271 0.99577270469628 322 3) Uncertain significance No change no 1 +Streptomycin gid p.Ala119Val gid_p.Ala119Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 4 3) Uncertain significance No change no 1 +Streptomycin gid p.Ala133fs gid_p.Ala133fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 6 0 10362 15608 0.000578703703703703 0.000212402724453782 0.00125916554902567 1 0.99976368249849 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 1672 2512 False False Inf 1.77302352643969 Inf 0 0 0.000355937358633142 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 6 6 0 6 0 7730 11874 0.00077559462254395 0.000284681048736677 0.00168737281383633 1 0.999689379610589 1 1 0.540741873560099 1 1 0.540741873560099 1 1 0.540741873560099 1 Inf 1.80798545886233 Inf 0.00376463732197043 47 2071 False False 0 0 0 0 0 0 0 Inf 1.80798545886233 Inf 0.00077559462254395 0.000284681048736677 0.00168737281383633 1 0.999689379610589 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Ala133Gly gid_p.Ala133Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 10367 15605 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999807790876473 0.99943838714673 0.999960360103688 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.64334605529666 0.280505932748473 259.5 2512 False False 0.501752355229735 0.00956153582768186 6.25014259670444 0 0 0.000355765720726338 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 3 7735 11871 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999747347145022 0.999261820436506 0.999947893876346 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.7148618120425 0.283378435813045 205.5 2071 False False 0 0 0 0 0 0 0 0.511570782159017 0.0097482170621519 6.37282132403124 0 0 0.000476793790149404 0.999747347145022 0.999261820436506 0.999947893876346 4 3) Uncertain significance No change no 1 +Streptomycin gid p.Ala133Pro gid_p.Ala133Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 2 2 10366 15606 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999871860584315 0.999537193839207 0.999984481345552 0.5 0.067585986488543 0.932414013511457 0.5 0.012579117093425 0.987420882906574 0.333333333333333 0.00840375865961264 0.905700675949754 1.50549874590005 0.019184358977771 118.078519203969 1 973.5 2512 False False 1.50549874590005 0.10909391082996 20.7696540777406 9.64599209028648e-05 2.44215077354346e-06 0.000537321795461189 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1304 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 4 3) Uncertain significance No change no 1 +Streptomycin gid p.Ala133Thr gid_p.Ala133Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 3 0 10365 15608 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 1 0.99976368249849 1 1 0.292401773821286 1 1 0.025 1 1 0.025 1 Inf 0.0386072452937345 Inf 0.399091399091399 297.5 2512 False False Inf 0.622129167636411 Inf 9.64692263168049e-05 2.44238636565143e-06 0.000537373619049235 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 3 0 7733 11874 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 1 0.999689379610589 1 1 0.292401773821286 1 1 0.025 1 1 0.025 1 Inf 0.0393664039281761 Inf 0.394430844553243 227 2071 False False 0 0 0 0 0 0 0 Inf 0.634338273987677 Inf 0.00012929919834497 3.27356691808869e-06 0.000720196139555935 1 0.999689379610589 1 3 3) Uncertain significance No change no 1 +Streptomycin gid p.Ala133Val gid_p.Ala133Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1683 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1393 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Ala134fs gid_p.Ala134fs 1 frameshift (see "Genomic_coordinates" sheet) 1 3 1 2 2 4 10366 15604 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999743721168631 0.999343955596995 0.999930168370675 0.333333333333333 0.0432718682927417 0.777221904496487 0.333333333333333 0.00840375865961264 0.905700675949754 0.2 0.00505076337946806 0.716417936118089 0.752652903723712 0.012761631823455 14.460147583694 1 973.5 2512 False False 0.752652903723712 0.0680519547847045 5.25297485318028 9.64599209028648e-05 2.44215077354346e-06 0.000537321795461189 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Ala134Glu gid_p.Ala134Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 21 21 0 22 0 10346 15608 0.00212191358024691 0.00133025485608362 0.00321085044734721 1 0.99976368249849 1 1 0.845627487184425 1 1 0.83890238478092 1 1 0.83890238478092 1 Inf 7.85313379713275 Inf 4.14722239341695e-09 16 2512 True False Inf 8.25922674786928 Inf 0.00202565833896016 0.00125433813195503 0.00309477595682799 1 0.99976368249849 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 14 14 0 15 0 7721 11874 0.00193898655635987 0.00108562946918638 0.00319605008438842 1 0.999689379610589 1 1 0.781980639089466 1 1 0.768364238349883 1 1 0.768364238349883 1 Inf 5.09856615108063 Inf 2.19266247275704e-06 18 2071 True False 0 0 0 0 0 0 0 Inf 5.51360376948071 Inf 0.00180995475113122 0.000989861300121741 0.00303493366848556 1 0.999689379610589 1 34 Assoc w R 1) Assoc w R No change yes 1 +Streptomycin gid p.Ala134Pro gid_p.Ala134Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 3 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Ala134Thr gid_p.Ala134Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance No change no 1 +Streptomycin gid p.Ala138fs gid_p.Ala138fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 10368 15604 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 8.01462049278838 0.520315555582948 435.5 2512 False False 0 0 2.28044779470556 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.17205443383047 0.522230766108178 361 2071 False False 0 0 0 0 0 0 0 0 0 3.71438150990605 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Ala138Glu gid_p.Ala138Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 11 9 2 10 2 10358 15606 0.000964506172839506 0.000462612020337809 0.00177304351401163 0.999871860584315 0.999537193839207 0.999984481345552 0.833333333333333 0.515862251314033 0.979137474539907 0.818181818181818 0.482244147639827 0.97716880170004 0.818181818181818 0.482244147639827 0.97716880170004 6.77997682950376 1.40284754251664 64.5552838892608 0.00949504597667851 67 2512 False False 7.53330758833751 1.60478662030748 70.8637470762236 0.000868139288125783 0.000397042963775769 0.00164735622486296 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 7 0 8 0 7728 11874 0.00103412616339193 0.000446564649135067 0.00203661849802302 1 0.999689379610589 1 1 0.63058335244718 1 1 0.590383602774996 1 1 0.590383602774996 1 Inf 2.21375853539439 Inf 0.00148361031274486 41 2071 False False 0 0 0 0 0 0 0 Inf 2.62150725084646 Inf 0.00090497737556561 0.000363922793878801 0.00186370471782919 1 0.999689379610589 1 44 3) Uncertain significance No change no 1 +Streptomycin gid p.Ala138Leu gid_p.Ala138Leu 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Ala138Pro gid_p.Ala138Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 3 4 3 4 10365 15604 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999743721168631 0.999343955596995 0.999930168370675 0.428571428571428 0.0989882784425078 0.815948432359917 0.428571428571428 0.0989882784425078 0.815948432359917 0.428571428571428 0.0989882784425078 0.815948432359917 1.12908827785817 0.165354282141397 6.67552078522212 1 973.5 2512 False False 1.12908827785817 0.165354282141397 6.67552078522212 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 1 4 1 4 7735 11870 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999663129526697 0.999137704464366 0.999908206750254 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 0.383645765998707 0.00779364023519555 3.87797408017955 0.654465279037393 494 2071 False False 0 0 0 0 0 0 0 0.383645765998707 0.00779364023519555 3.87797408017955 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999663129526697 0.999137704464366 0.999908206750254 6 3) Uncertain significance No change no 1 +Streptomycin gid p.Ala138Ser gid_p.Ala138Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Ala138Thr gid_p.Ala138Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 2 3 2 4 10366 15604 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999743721168631 0.999343955596995 0.999930168370675 0.333333333333333 0.0432718682927417 0.777221904496487 0.4 0.0527449505263169 0.853367200365326 0.333333333333333 0.0432718682927417 0.777221904496487 1.00353720496494 0.0837786939964311 8.76315005873756 1 973.5 2512 False False 0.752652903723712 0.0680519547847045 5.25297485318028 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 2 2 2 3 7734 11871 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999747347145022 0.999261820436506 0.999947893876346 0.4 0.0527449505263169 0.853367200365326 0.5 0.067585986488543 0.932414013511457 0.4 0.0527449505263169 0.853367200365326 1.53491078355314 0.111219596320004 21.1765312831251 0.649684606669322 487.5 2071 False False 0 0 0 0 0 0 0 1.02327385570209 0.0854221600622099 8.93608975066686 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999747347145022 0.999261820436506 0.999947893876346 7 3) Uncertain significance No change no 1 +Streptomycin gid p.Ala138Val gid_p.Ala138Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 42 26 16 37 21 10331 15587 0.00356867283950617 0.00251388203619829 0.00491562313397047 0.998654536135315 0.997944046996364 0.999166949785744 0.637931034482758 0.501178979508997 0.760079180593698 0.619047619047619 0.456367495497898 0.764279453136783 0.553191489361702 0.401157229565357 0.698278476023999 2.45173506920917 1.26580783395539 4.89431411931418 0.00430702060341914 54 2512 False False 2.65829150361141 1.51481989825471 4.78272816904026 0.0025103794535097 0.0016404983812918 0.00367613915371329 0.998654536135315 0.997944046996364 0.999166949785744 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 29 18 11 28 15 7708 11859 0.00361944157187176 0.00240639920597165 0.00522688409448799 0.998736735725113 0.997917292278642 0.999292793629768 0.651162790697674 0.490733639524638 0.78992184299333 0.620689655172413 0.422604640664401 0.793131300513492 0.545454545454545 0.363506531014846 0.718933805706183 2.51759682974005 1.12529624182269 5.9019537224022 0.0206950050800674 65 2071 False False 0 0 0 0 0 0 0 2.87192527244421 1.48132473078884 5.78979939974736 0.0023297954957287 0.00138135079495903 0.00367959146931941 0.998736735725113 0.997917292278642 0.999292793629768 64 3) Uncertain significance No change no 1 +Streptomycin gid p.Ala140fs gid_p.Ala140fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1611 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1326 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Ala140Pro gid_p.Ala140Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 3 0 10365 15608 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 1 0.99976368249849 1 1 0.292401773821286 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.282763354911628 Inf 0.159283177454496 169.5 2512 False False Inf 0.622129167636411 Inf 0.000192919841805729 2.33643418036207e-05 0.000696717215522511 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 3 0 7733 11874 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 1 0.999689379610589 1 1 0.292401773821286 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.288317028192402 Inf 0.155587872029136 119.5 2071 False False 0 0 0 0 0 0 0 Inf 0.634338273987677 Inf 0.000258564964447317 3.13149507641486e-05 0.00093371015947595 1 0.999689379610589 1 1 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Ala140Ser gid_p.Ala140Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1654 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Ala140Val gid_p.Ala140Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.50544998553101 0.0191837380556942 118.074698097101 1 973.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.53497091144149 0.0195519049186736 120.390152361053 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Ala141Glu gid_p.Ala141Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 10367 15605 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999807790876473 0.99943838714673 0.999960360103688 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.64334605529666 0.280505932748473 259.5 2512 False False 0.501752355229735 0.00956153582768186 6.25014259670444 0 0 0.000355765720726338 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 3 7735 11871 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999747347145022 0.999261820436506 0.999947893876346 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.7148618120425 0.283378435813045 205.5 2071 False False 0 0 0 0 0 0 0 0.511570782159017 0.0097482170621519 6.37282132403124 0 0 0.000476793790149404 0.999747347145022 0.999261820436506 0.999947893876346 3 3) Uncertain significance No change no 1 +Streptomycin gid p.Ala141Thr gid_p.Ala141Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Ala161Asp gid_p.Ala161Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 4 1 5 1 10363 15607 0.000482253086419753 0.000156604214122162 0.00112505595550109 0.999935930292158 0.99964307871082 0.999998377896754 0.833333333333333 0.358765421002325 0.99578925548551 0.8 0.28358206388191 0.994949236620532 0.8 0.28358206388191 0.994949236620532 6.02412428833349 0.595994370665572 296.243160147818 0.0863410732250285 123 2512 False False 7.53015536041686 0.842353453161053 355.554202953959 0.000385839683611459 0.000105138014297713 0.000987605477659245 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 4 1 5 1 7731 11873 0.000646328852119958 0.0002098934625097 0.00150766595359595 0.999915782381674 0.999530859783396 0.999997867796783 0.833333333333333 0.358765421002325 0.99578925548551 0.8 0.28358206388191 0.994949236620532 0.8 0.28358206388191 0.994949236620532 6.14306040615703 0.607709465847441 302.087562600957 0.0828280801794821 101 2071 False False 0 0 0 0 0 0 0 7.67882550769628 0.858951237970164 362.566724149337 0.000517129928894634 0.000140917901974878 0.00132352387806833 0.999915782381674 0.999530859783396 0.999997867796783 3 3) Uncertain significance No change no 1 +Streptomycin gid p.Ala161Gly gid_p.Ala161Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 6 10366 15602 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999615581752947 0.999163472525571 0.999858912630967 0.25 0.0318540262499442 0.650855794412824 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1615 2512 False False 0.50170428966493 0.0495150381555913 2.80649490654312 0 0 0.000355800035063835 0.999615581752947 0.999163472525571 0.999858912630967 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1331 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 4 3) Uncertain significance No change no 1 +Streptomycin gid p.Ala161Pro gid_p.Ala161Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Ala161Val gid_p.Ala161Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1655 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1366 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 3 3) Uncertain significance No change no 1 +Streptomycin gid p.Ala167Asp gid_p.Ala167Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 5 2 10 3 10358 15605 0.000964506172839506 0.000462612020337809 0.00177304351401163 0.999807790876473 0.99943838714673 0.999960360103688 0.769230769230769 0.461868460765959 0.949618926508848 0.714285714285714 0.290420863737342 0.963307433823914 0.625 0.244863216366551 0.914766585862746 3.76641243483297 0.616444965696903 39.5582374644897 0.123592034289277 134 2512 False False 5.02188324644397 1.2925693817223 28.3812187360808 0.000482485766669883 0.000156679782092836 0.00112559860432046 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 5 2 10 3 7726 11871 0.00129265770423991 0.000620048157733657 0.00237595446225449 0.999747347145022 0.999261820436506 0.999947893876346 0.769230769230769 0.461868460765959 0.949618926508848 0.714285714285714 0.290420863737342 0.963307433823914 0.625 0.244863216366551 0.914766585862746 3.8412503235827 0.628635149391607 40.3530763182505 0.120728155439357 115 2071 False False 0 0 0 0 0 0 0 5.12166709811027 1.31809017901265 28.9886302790483 0.000646746863277713 0.000210029231320679 0.0015086406112362 0.999747347145022 0.999261820436506 0.999947893876346 14 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Ala167fs gid_p.Ala167fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Ala167Pro gid_p.Ala167Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 8 10368 15600 0 0 0.000355731413006942 0.999487442337262 0.998990308225149 0.99977868883794 0 0 0.369416647552819 0 0 0.409616397225003 0 0 0.369416647552819 0 0 1.04420213710049 0.0468674251395475 98 2512 False False 0 0 0.881730950187969 0 0 0.000355731413006942 0.999487442337262 0.998990308225149 0.99977868883794 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 7736 11869 0 0 0.000476732171726368 0.999578911908371 0.999017596768841 0.999863260157969 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.67480496260254 0.164218902979591 159.5 2071 False False 0 0 0 0 0 0 0 0 0 1.67480496260254 0 0 0.000476732171726368 0.999578911908371 0.999017596768841 0.999863260157969 17 3) Uncertain significance No change no 1 +Streptomycin gid p.Ala167Ser gid_p.Ala167Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Ala180Gly gid_p.Ala180Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0385973247056878 Inf 0.399153031761308 409.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 3) Uncertain significance No change no 1 +Streptomycin gid p.Ala180Ser gid_p.Ala180Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1628 2512 False False Inf 0.282736080598822 Inf 0 0 0.000355800035063835 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Ala183fs gid_p.Ala183fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Ala183Glu gid_p.Ala183Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 3 3) Uncertain significance No change no 1 +Streptomycin gid p.Ala183Pro gid_p.Ala183Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 58.6634076928655 1 973.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 5 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Ala183Thr gid_p.Ala183Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Ala183Val gid_p.Ala183Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Ala193fs gid_p.Ala193fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.50544998553101 0.0191837380556942 118.074698097101 1 973.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Ala193Gly gid_p.Ala193Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 58.6540000158548 1 973.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1285 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Ala193Pro gid_p.Ala193Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Ala19Asp gid_p.Ala19Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Ala19fs gid_p.Ala19fs 1 frameshift (see "Genomic_coordinates" sheet) 1 6 3 3 3 3 10365 15605 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999807790876473 0.99943838714673 0.999960360103688 0.5 0.118117248757025 0.881882751242974 0.5 0.118117248757025 0.881882751242974 0.5 0.118117248757025 0.881882751242974 1.50554751567776 0.201606412693291 11.2464963121379 0.688485290567795 592 2512 False False 1.50554751567776 0.201606412693291 11.2464963121379 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 4 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Ala19Gly gid_p.Ala19Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance No change no 1 +Streptomycin gid p.Ala19Pro gid_p.Ala19Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 3 1 5 3 10363 15605 0.000482253086419753 0.000156604214122162 0.00112505595550109 0.999807790876473 0.99943838714673 0.999960360103688 0.625 0.244863216366551 0.914766585862746 0.75 0.194120449683243 0.99369053679029 0.5 0.118117248757025 0.881882751242974 4.51751423333011 0.362648718988 236.869923655706 0.308512565711993 275 2512 False False 2.50973012962784 0.48813575589439 16.1645252811411 0.000289407678950414 5.96867980365928e-05 0.000845536799804338 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 3 3 7733 11871 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 0.999747347145022 0.999261820436506 0.999947893876346 0.5 0.118117248757025 0.881882751242974 0.5 0.012579117093425 0.987420882906574 0.25 0.00630946320970987 0.805879550316756 1.53510927195137 0.019553666686456 120.400995089387 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53510927195137 0.205550714955708 11.4678941037862 0.00012929919834497 3.27356691808869e-06 0.000720196139555935 0.999747347145022 0.999261820436506 0.999947893876346 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Ala19Ser gid_p.Ala19Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1629 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance No change no 1 +Streptomycin gid p.Ala19Thr gid_p.Ala19Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 4 2 5 2 10363 15606 0.000482253086419753 0.000156604214122162 0.00112505595550109 0.999871860584315 0.999537193839207 0.999984481345552 0.714285714285714 0.290420863737342 0.963307433823914 0.666666666666666 0.222778095503512 0.956728131707258 0.666666666666666 0.222778095503512 0.956728131707258 3.01186914986007 0.431544912878221 33.3073857873502 0.225004152886249 210.5 2512 False False 3.76483643732509 0.616187094146839 39.5416182494222 0.000385839683611459 0.000105138014297713 0.000987605477659245 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 4 1 4 1 7732 11873 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.999915782381674 0.999530859783396 0.999997867796783 0.8 0.28358206388191 0.994949236620532 0.8 0.28358206388191 0.994949236620532 0.8 0.28358206388191 0.994949236620532 6.14226590791515 0.607630898004113 302.048561734113 0.0828510346178796 103 2071 False False 0 0 0 0 0 0 0 6.14226590791515 0.607630898004113 302.048561734113 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.999915782381674 0.999530859783396 0.999997867796783 4 3) Uncertain significance No change no 1 +Streptomycin gid p.Ala200fs gid_p.Ala200fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Ala200Glu gid_p.Ala200Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 13 12 1 13 2 10355 15606 0.00125385802469135 0.000667790166179422 0.00214318097672708 0.999871860584315 0.999537193839207 0.999984481345552 0.866666666666666 0.595397303396627 0.983424086559916 0.923076923076923 0.639702564732122 0.998054371502653 0.857142857142857 0.571870839090301 0.982205484516808 18.0851762433606 2.67503762165918 770.366247105724 0.000133737039976163 38 2512 True False 9.79613713182037 2.216861718101 89.4749484212046 0.00115751905083437 0.000598245495225259 0.00202107893124786 0.999871860584315 0.999537193839207 0.999984481345552 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 13 12 1 13 2 7723 11872 0.00168045501551189 0.000895065386794453 0.00287191489837179 0.999831564763348 0.99939168785815 0.999979601060482 0.866666666666666 0.595397303396627 0.983424086559916 0.923076923076923 0.639702564732122 0.998054371502653 0.857142857142857 0.571870839090301 0.982205484516808 18.4467175967888 2.72811381356597 785.718201342332 0.000116847490491227 32 2071 True False 0 0 0 0 0 0 0 9.99197203159394 2.26109098835743 91.2303219185863 0.0015513897866839 0.00080187459052782 0.00270839593828829 0.999831564763348 0.99939168785815 0.999979601060482 4 1) Assoc w R UP from Uncertain to AwR yes 4 +Streptomycin gid p.Ala200Val gid_p.Ala200Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Ala205fs gid_p.Ala205fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0386035211949905 Inf 0.399114533205004 308.5 2512 False False Inf 0.282736080598822 Inf 9.64599209028648e-05 2.44215077354346e-06 0.000537321795461189 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1382 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Ala205Glu gid_p.Ala205Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0386035211949905 Inf 0.399114533205004 308.5 2512 False False Inf 0.282736080598822 Inf 9.64599209028648e-05 2.44215077354346e-06 0.000537321795461189 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0393613144801391 Inf 0.394461726758121 237.5 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0.000129282482223658 3.27314370392442e-06 0.000720103058325324 1 0.999689379610589 1 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Ala205Thr gid_p.Ala205Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 33 0 33 9 37 10359 15571 0.000868055555555555 0.000397004661559041 0.00164719739830421 0.997629420809841 0.99673393465183 0.99833036109224 0.195652173913043 0.0935757344214085 0.339147599510998 0 0 0.105762810074579 0 0 0.0948905874149899 0 0 0.177835772424989 6.51471786878093e-08 19 2512 True False 0.365628008547209 0.155121254930765 0.771833163082562 0 0 0.000356040420894094 0.997629420809841 0.99673393465183 0.99833036109224 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 29 0 29 6 31 7730 11843 0.00077559462254395 0.000284681048736677 0.00168737281383633 0.997389253831901 0.996296283622464 0.998225456465932 0.162162162162162 0.0619257213333963 0.320137075867671 0 0 0.119444869069502 0 0 0.11218874692237 0 0 0.207933255552741 7.51121856807929e-07 16 2071 True False 0 0 0 0 0 0 0 0.296532153737011 0.101071714616449 0.721900954806284 0 0 0.000477102121347592 0.997389253831901 0.996296283622464 0.998225456465932 19 3) Uncertain significance No change no 1 +Streptomycin gid p.Ala205Val gid_p.Ala205Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Ala219Val gid_p.Ala219Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 5 10368 15603 0 0 0.000355731413006942 0.999679651460789 0.999252573060182 0.999895975781355 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 3.64252769649333 0.280473333374422 223.5 2512 False False 0 0 1.64266120859479 0 0 0.000355731413006942 0.999679651460789 0.999252573060182 0.999895975781355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 5 7736 11869 0 0 0.000476732171726368 0.999578911908371 0.999017596768841 0.999863260157969 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 3.71375573911164 0.283333413446937 176 2071 False False 0 0 0 0 0 0 0 0 0 1.67480496260254 0 0 0.000476732171726368 0.999578911908371 0.999017596768841 0.999863260157969 6 3) Uncertain significance No change no 1 +Streptomycin gid p.Ala224Val gid_p.Ala224Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 10368 15603 0 0 0.000355731413006942 0.999679651460789 0.999252573060182 0.999895975781355 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 2.28030160110266 0.155688368476676 145 2512 False False 0 0 1.64266120859479 0 0 0.000355731413006942 0.999679651460789 0.999252573060182 0.999895975781355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 7736 11870 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.32513012450998 0.158605093840654 142 2071 False False 0 0 0 0 0 0 0 0 0 2.32513012450998 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 1 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Ala23Asp gid_p.Ala23Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 58.6596525903968 1 973.5 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 0 0 0.000355765720726338 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1327 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 5 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Ala23Pro gid_p.Ala23Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Ala25Gly gid_p.Ala25Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Ala25Pro gid_p.Ala25Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 3 1 10365 15607 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999935930292158 0.99964307871082 0.999998377896754 0.75 0.194120449683243 0.99369053679029 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.50574047274481 0.0191874378630812 118.097459292191 1 973.5 2512 False False 4.51722141823444 0.362625225225282 236.854590713406 9.64692263168049e-05 2.44238636565143e-06 0.000537373619049235 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 3 1 7733 11873 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 0.999915782381674 0.999530859783396 0.999997867796783 0.75 0.194120449683243 0.99369053679029 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.53536790378895 0.019556961098611 120.421258157378 1 512 2071 False False 0 0 0 0 0 0 0 4.60610371136686 0.369734697559289 241.512824517625 0.00012929919834497 3.27356691808869e-06 0.000720196139555935 0.999915782381674 0.999530859783396 0.999997867796783 6 3) Uncertain significance No change no 1 +Streptomycin gid p.Ala25Val gid_p.Ala25Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance No change no 1 +Streptomycin gid p.Ala27Pro gid_p.Ala27Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 1 5 3 5 10365 15603 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999679651460789 0.999252573060182 0.999895975781355 0.375 0.0852334141372535 0.755136783633448 0.166666666666666 0.00421074451448947 0.641234578997674 0.166666666666666 0.00421074451448947 0.641234578997674 0.301070911722141 0.00636919672576793 2.69121155395022 0.412585507521083 419 2512 False False 0.903212735166425 0.140213309764784 4.64350502715881 9.64692263168049e-05 2.44238636565143e-06 0.000537373619049235 0.999679651460789 0.999252573060182 0.999895975781355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 1 3 2 3 7734 11871 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999747347145022 0.999261820436506 0.999947893876346 0.4 0.0527449505263169 0.853367200365326 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.511636927851047 0.00974947663174677 6.37364544566016 1 806.5 2071 False False 0 0 0 0 0 0 0 1.02327385570209 0.0854221600622099 8.93608975066686 0.000129282482223658 3.27314370392442e-06 0.000720103058325324 0.999747347145022 0.999261820436506 0.999947893876346 27 3) Uncertain significance No change no 1 +Streptomycin gid p.Ala27Val gid_p.Ala27Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1622 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1336 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Ala53Asp gid_p.Ala53Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 58.6634076928655 1 973.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1337 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 2 3) Uncertain significance No change no 1 +Streptomycin gid p.Ala72Asp gid_p.Ala72Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1673 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1383 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Ala72Thr gid_p.Ala72Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 10366 15607 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999935930292158 0.99964307871082 0.999998377896754 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 58.6690617185945 1 973.5 2512 False False 3.01119043025274 0.156729426968348 177.474331043773 0 0 0.000355800035063835 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1305 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 1 3) Uncertain significance No change no 1 +Streptomycin gid p.Ala72Val gid_p.Ala72Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 2 1 10366 15607 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999935930292158 0.99964307871082 0.999998377896754 0.666666666666666 0.0942993240502461 0.991596241340387 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.50559521512637 0.0191855877809429 118.086077597882 1 610 2512 False False 3.01119043025274 0.156729426968348 177.474331043773 9.64599209028648e-05 2.44215077354346e-06 0.000537321795461189 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 59.8138891519084 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Ala80Glu gid_p.Ala80Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.50544998553101 0.0191837380556942 118.074698097101 1 973.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.53497091144149 0.0195519049186736 120.390152361053 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 6 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Ala80Pro gid_p.Ala80Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 6 1 17 1 10351 15607 0.00163966049382716 0.0009554436768022 0.00262396149717064 0.999935930292158 0.99964307871082 0.999998377896754 0.944444444444444 0.727056400326631 0.99859444383263 0.857142857142857 0.421276802956804 0.996389703138099 0.857142857142857 0.421276802956804 0.996389703138099 9.04666215824558 1.09727296998255 415.313119567661 0.0185423317354822 77 2512 False False 25.6322094483624 4.01527480477618 1065.93254213598 0.000579318335425316 0.000212628344390938 0.00126050243228172 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 6 0 16 0 7720 11874 0.00206825232678386 0.00118263260320744 0.00335654494667737 1 0.999689379610589 1 1 0.794092785792177 1 1 0.540741873560099 1 1 0.540741873560099 1 Inf 1.81033479022423 Inf 0.00374697514929998 45 2071 False False 0 0 0 0 0 0 0 Inf 5.92898660200167 Inf 0.000776598498576236 0.000285049586949998 0.00168955583449286 1 0.999689379610589 1 9 3) Uncertain significance No change no 1 +Streptomycin gid p.Ala80Val gid_p.Ala80Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.01513406993295 0.520321755085951 445 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 59.801132462225 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 2 3) Uncertain significance No change no 1 +Streptomycin gid p.Ala82fs gid_p.Ala82fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Ala82Glu gid_p.Ala82Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 58.6540000158548 1 973.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1300 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Ala82Pro gid_p.Ala82Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 3 1 7 1 10361 15607 0.000675154320987654 0.000271488767107418 0.00139057803317028 0.999935930292158 0.99964307871082 0.999998377896754 0.875 0.473490329124793 0.996840276468748 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 4.51896535083486 0.362765206314917 236.945898544083 0.308490960058353 272 2512 False False 10.5442524852813 1.35425443486503 474.171593318211 0.000289463527595522 5.96983169050341e-05 0.000845699922446725 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 2 1 5 1 7731 11873 0.000646328852119958 0.0002098934625097 0.00150766595359595 0.999915782381674 0.999530859783396 0.999997867796783 0.833333333333333 0.358765421002325 0.99578925548551 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 3.07153020307851 0.159861632605525 181.029874007598 0.566029924660661 471.5 2071 False False 0 0 0 0 0 0 0 7.67882550769628 0.858951237970164 362.566724149337 0.000258631837579206 3.13230502042936e-05 0.00093395156507162 0.999915782381674 0.999530859783396 0.999997867796783 4 3) Uncertain significance No change no 1 +Streptomycin gid p.Ala8Glu gid_p.Ala8Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Ala8Pro gid_p.Ala8Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Ala8Val gid_p.Ala8Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 5 10367 15603 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999679651460789 0.999252573060182 0.999895975781355 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.707598226178713 0 0 0.521823750104981 0 0 3.64287911360527 0.28048732963455 230 2512 False False 0.30101282916948 0.00636796908209055 2.69069235774657 0 0 0.000355765720726338 0.999679651460789 0.999252573060182 0.999895975781355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 3 7735 11871 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999747347145022 0.999261820436506 0.999947893876346 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.17311098997073 0.522243797058548 447.5 2071 False False 0 0 0 0 0 0 0 0.511570782159017 0.0097482170621519 6.37282132403124 0 0 0.000476793790149404 0.999747347145022 0.999261820436506 0.999947893876346 13 3) Uncertain significance No change no 1 +Streptomycin gid p.Arg102fs gid_p.Arg102fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 10 0 10358 15608 0.000964506172839506 0.000462612020337809 0.00177304351401163 1 0.99976368249849 1 1 0.691502892181239 1 NA NA NA NA NA NA NA NA NA NA 1660 2512 False False Inf 3.37651739769836 Inf 0 0 0.000356074788245403 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Arg102Gly gid_p.Arg102Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance No change no 1 +Streptomycin gid p.Arg102Pro gid_p.Arg102Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 0 10364 15608 0.000385802469135802 0.000105127872737001 0.000987510251175401 1 0.99976368249849 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 1554 2512 False False Inf 0.993868422549659 Inf 0 0 0.000355868683600791 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1278 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0 0 0.000476855424503066 1 0.999689379610589 1 3 3) Uncertain significance No change no 1 +Streptomycin gid p.Arg102* gid_p.Arg102* 1 stop_gained (see "Genomic_coordinates" sheet) 1 5 2 3 2 3 10366 15605 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999807790876473 0.99943838714673 0.999960360103688 0.4 0.0527449505263169 0.853367200365326 0.4 0.0527449505263169 0.853367200365326 0.4 0.0527449505263169 0.853367200365326 1.00360151778249 0.0837840645585397 8.76371184924575 1 973.5 2512 False False 1.00360151778249 0.0837840645585397 8.76371184924575 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.53497091144149 0.0195519049186736 120.390152361053 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 5 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Arg116fs gid_p.Arg116fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1558 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Arg116Gln gid_p.Arg116Gln 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1561 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1282 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Arg116Gly gid_p.Arg116Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 2 4 10366 15604 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999743721168631 0.999343955596995 0.999930168370675 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.6434640919271 0.280510633342664 264 2512 False False 0.752652903723712 0.0680519547847045 5.25297485318028 0 0 0.000355800035063835 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.71438150990605 0.283358886007265 193.5 2071 False False 0 0 0 0 0 0 0 0 0 3.71438150990605 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 2 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Arg116Trp gid_p.Arg116Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 1 3 10367 15605 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999807790876473 0.99943838714673 0.999960360103688 0.25 0.00630946320970987 0.805879550316756 0.333333333333333 0.00840375865961264 0.905700675949754 0.25 0.00630946320970987 0.805879550316756 0.752628532844603 0.0127612189150725 14.4596792780633 1 973.5 2512 False False 0.501752355229735 0.00956153582768186 6.25014259670444 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Streptomycin gid p.Arg118_Ser149del gid_p.Arg118_Ser149del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.6429945931141 0.280491932584249 243 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Streptomycin gid p.Arg118Cys gid_p.Arg118Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Arg118fs gid_p.Arg118fs 1 frameshift (see "Genomic_coordinates" sheet) 1 154 87 67 124 97 10244 15511 0.0119598765432098 0.00995717095037427 0.0142432428554927 0.993785238339313 0.992423704155128 0.994957441998818 0.561085972850678 0.492949751322205 0.627561246016518 0.564935064935065 0.482781283249238 0.644541389235047 0.472826086956521 0.398929184402729 0.547612568865997 1.96614108294917 1.41185948424115 2.74848566783445 3.23596358148151e-05 32 2512 True False 1.93562034804381 1.4701718355739 2.55442370361499 0.00842125641273836 0.00675042209144988 0.0103773617819071 0.993785238339313 0.992423704155128 0.994957441998818 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance 1 98 51 47 77 72 7659 11802 0.00995346432264736 0.00786287709644401 0.0124246309747702 0.993936331480545 0.992369822703943 0.995252617322906 0.516778523489932 0.433557074549993 0.599319575820882 0.520408163265306 0.417121466822883 0.622428637037775 0.414634146341463 0.326541114263653 0.506936017180895 1.67207540565542 1.10143006239944 2.54301058850505 0.0125797523855726 61 2071 False False 0 0 0 0 0 0 0 1.64794141968055 1.17777383010648 2.30785663660329 0.00661478599221789 0.00492899271847046 0.00868815816549262 0.993936331480545 0.992369822703943 0.995252617322906 248 Evidence from ALL dataset only 2) Assoc w R - Interim No change no ALL only 1 +Streptomycin gid p.Arg118His gid_p.Arg118His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 3 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Arg118Leu gid_p.Arg118Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 10366 15607 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999935930292158 0.99964307871082 0.999998377896754 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 58.6690617185945 1 973.5 2512 False False 3.01119043025274 0.156729426968348 177.474331043773 0 0 0.000355800035063835 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 7734 11873 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999915782381674 0.999530859783396 0.999997867796783 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 59.821615810862 1 806.5 2071 False False 0 0 0 0 0 0 0 3.07033876389966 0.159799628612092 180.959738606129 0 0 0.000476855424503066 0.999915782381674 0.999530859783396 0.999997867796783 3 3) Uncertain significance No change no 1 +Streptomycin gid p.Arg118Pro gid_p.Arg118Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1603 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1319 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 3 3) Uncertain significance No change no 1 +Streptomycin gid p.Arg118Ser gid_p.Arg118Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 3 2 3 2 10365 15606 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999871860584315 0.999537193839207 0.999984481345552 0.6 0.146632799634673 0.947255049473683 0.6 0.146632799634673 0.947255049473683 0.6 0.146632799634673 0.947255049473683 2.25846599131693 0.258657968313028 27.0476864113414 0.394237929959746 288 2512 False False 2.25846599131693 0.258657968313028 27.0476864113414 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 3 1 3 1 7733 11873 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 0.999915782381674 0.999530859783396 0.999997867796783 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 4.60610371136686 0.369734697559289 241.512824517625 0.307287813162931 214 2071 False False 0 0 0 0 0 0 0 4.60610371136686 0.369734697559289 241.512824517625 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance No change no 1 +Streptomycin gid p.Arg137Gln gid_p.Arg137Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 3 5 3 5 10365 15603 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999679651460789 0.999252573060182 0.999895975781355 0.375 0.0852334141372535 0.755136783633448 0.375 0.0852334141372535 0.755136783633448 0.375 0.0852334141372535 0.755136783633448 0.903212735166425 0.140213309764784 4.64350502715881 1 973.5 2512 False False 0.903212735166425 0.140213309764784 4.64350502715881 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999679651460789 0.999252573060182 0.999895975781355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 3 5 3 5 7733 11869 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 0.999578911908371 0.999017596768841 0.999863260157969 0.375 0.0852334141372535 0.755136783633448 0.375 0.0852334141372535 0.755136783633448 0.375 0.0852334141372535 0.755136783633448 0.920910384068278 0.142953020895037 4.73486197483818 1 806.5 2071 False False 0 0 0 0 0 0 0 0.920910384068278 0.142953020895037 4.73486197483818 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 0.999578911908371 0.999017596768841 0.999863260157969 2 3) Uncertain significance No change no 1 +Streptomycin gid p.Arg137Leu gid_p.Arg137Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 3 1 3 1 10365 15607 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999935930292158 0.99964307871082 0.999998377896754 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 4.51722141823444 0.362625225225282 236.854590713406 0.308516935797272 279.5 2512 False False 4.51722141823444 0.362625225225282 236.854590713406 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.53497091144149 0.0195519049186736 120.390152361053 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 4 3) Uncertain significance No change no 1 +Streptomycin gid p.Arg137Pro gid_p.Arg137Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 4 4 6 4 10362 15604 0.000578703703703703 0.000212402724453782 0.00125916554902567 0.999743721168631 0.999343955596995 0.999930168370675 0.6 0.262378076606945 0.878447741880172 0.5 0.157012770487058 0.842987229512941 0.5 0.157012770487058 0.842987229512941 1.50588689442192 0.280411788394993 8.08749726938038 0.721059566406332 594 2512 False False 2.25883034163288 0.535491434983611 10.8863434801125 0.000385876905267219 0.000105148157815303 0.000987700722510407 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 1 4 2 4 7734 11870 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999663129526697 0.999137704464366 0.999908206750254 0.333333333333333 0.0432718682927417 0.777221904496487 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 0.383695371088699 0.00779464714435664 3.87847561846721 0.654466509312243 496 2071 False False 0 0 0 0 0 0 0 0.767390742177398 0.0693820092373707 5.35625075908251 0.000129282482223658 3.27314370392442e-06 0.000720103058325324 0.999663129526697 0.999137704464366 0.999908206750254 2 3) Uncertain significance No change no 1 +Streptomycin gid p.Arg137Trp gid_p.Arg137Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 25 15 10 21 11 10347 15597 0.00202546296296296 0.00125421710937554 0.00309447762369452 0.999295233213736 0.998739328260189 0.999648132128855 0.65625 0.468068963719731 0.814280908283433 0.6 0.386653496256839 0.788745193534858 0.576923076923076 0.369180380923966 0.766478016872556 2.26109017106407 0.949834232301849 5.63047609275237 0.0635099929474145 109 2512 False False 2.87775112680882 1.32568957465157 6.61072890089214 0.00144759698899826 0.000810428281764166 0.00238646890209865 0.999295233213736 0.998739328260189 0.999648132128855 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 21 13 8 16 8 7720 11866 0.00206825232678386 0.00118263260320744 0.00335654494667737 0.999326259053394 0.998672895689377 0.999709083033384 0.666666666666666 0.446780384340351 0.843697714290864 0.619047619047619 0.384354390378645 0.818928374459826 0.619047619047619 0.384354390378645 0.818928374459826 2.49770077720207 0.95903228490122 6.95492708141667 0.0436980803648387 77 2071 False False 0 0 0 0 0 0 0 3.0740932642487 1.24053303291676 8.3004734939053 0.00168110694426483 0.00089541273952674 0.00287302838597929 0.999326259053394 0.998672895689377 0.999709083033384 26 3) Uncertain significance No change no 1 +Streptomycin gid p.Arg154Pro gid_p.Arg154Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 17 4 13 7 16 10361 15592 0.000675154320987654 0.000271488767107418 0.00139057803317028 0.998974884674526 0.998335809333792 0.999413948080433 0.304347826086956 0.132102879698099 0.529191666008506 0.235294117647058 0.0681077404373566 0.49899327320458 0.2 0.0573339970500327 0.436614002996668 0.463038168278975 0.109952416048156 1.49939090043692 0.218023154082256 208 2512 False False 0.658382395521667 0.228973022871038 1.69228665527628 0.000385914134105161 0.000105158303290336 0.000987795985734201 0.998974884674526 0.998335809333792 0.999413948080433 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 15 3 12 5 15 7731 11859 0.000646328852119958 0.0002098934625097 0.00150766595359595 0.998736735725113 0.997917292278642 0.999292793629768 0.25 0.0865714691014345 0.491045871707957 0.2 0.0433120051058366 0.480891133806853 0.166666666666666 0.0357850831215746 0.414177491394774 0.38348855258052 0.0694244136472945 1.42175822716699 0.185195388771966 165 2071 False False 0 0 0 0 0 0 0 0.51131807010736 0.145331267874464 1.4807912043683 0.00038789759503491 8.00009542696687e-05 0.00113317878297119 0.998736735725113 0.997917292278642 0.999292793629768 40 3) Uncertain significance No change no 1 +Streptomycin gid p.Arg154Trp gid_p.Arg154Trp 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Streptomycin gid p.Arg158fs gid_p.Arg158fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 58.6540000158548 1 973.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 59.801132462225 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 9 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Arg158Gly gid_p.Arg158Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Arg158Leu gid_p.Arg158Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 10365 15608 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 1 0.99976368249849 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1551 2512 False False Inf 0.622129167636411 Inf 0 0 0.000355834356021348 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1275 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 1 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Arg158Pro gid_p.Arg158Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.50544998553101 0.0191837380556942 118.074698097101 1 973.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.53497091144149 0.0195519049186736 120.390152361053 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Arg158* gid_p.Arg158* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0386035211949905 Inf 0.399114533205004 308.5 2512 False False Inf 0.282736080598822 Inf 9.64599209028648e-05 2.44215077354346e-06 0.000537321795461189 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 3 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Arg15fs gid_p.Arg15fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Arg15Pro gid_p.Arg15Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.6429945931141 0.280491932584249 243 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 4 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Arg15Trp gid_p.Arg15Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 10368 15604 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 8.01462049278838 0.520315555582948 435.5 2512 False False 0 0 2.28044779470556 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 4 7736 11870 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 8.17136611448302 0.522222275631291 353.5 2071 False False 0 0 0 0 0 0 0 0 0 2.32513012450998 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Arg166Pro gid_p.Arg166Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1565 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1286 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 1 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Arg166Trp gid_p.Arg166Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.752676762805054 0.0127620362920002 14.460605698152 1 1332 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.53497091144149 0.0195519049186736 120.390152361053 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance No change no 1 +Streptomycin gid p.Arg172Trp gid_p.Arg172Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1612 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1328 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Arg175Gly gid_p.Arg175Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 58.6540000158548 1 973.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 59.801132462225 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 1 3) Uncertain significance No change no 1 +Streptomycin gid p.Arg175Pro gid_p.Arg175Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Arg176Cys gid_p.Arg176Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 1 3) Uncertain significance No change no 1 +Streptomycin gid p.Arg176fs gid_p.Arg176fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Arg176Ser gid_p.Arg176Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 7 10368 15601 0 0 0.000355731413006942 0.999551512045105 0.999076163117038 0.999819666176692 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 1.04426933597617 0.0468685590567948 99 2512 False False 0 0 1.04426933597617 0 0 0.000355731413006942 0.999551512045105 0.999076163117038 0.999819666176692 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 7 7736 11867 0 0 0.000476732171726368 0.999410476671719 0.998785736251934 0.999762949244471 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 1.06467742986826 0.047267663661775 82 2071 False False 0 0 0 0 0 0 0 0 0 1.06467742986826 0 0 0.000476732171726368 0.999410476671719 0.998785736251934 0.999762949244471 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Arg187Lys gid_p.Arg187Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1586 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1306 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Arg187Ser gid_p.Arg187Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Arg197Cys gid_p.Arg197Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 2 10366 15606 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999871860584315 0.999537193839207 0.999984481345552 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 58.6653062545381 1 973.5 2512 False False 1.50549874590005 0.10909391082996 20.7696540777406 0 0 0.000355800035063835 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 2 7734 11872 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999831564763348 0.99939168785815 0.999979601060482 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 59.8165824855725 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53504008275148 0.111228967362952 21.1783159842378 0 0 0.000476855424503066 0.999831564763348 0.99939168785815 0.999979601060482 9 3) Uncertain significance No change no 1 +Streptomycin gid p.Arg197Pro gid_p.Arg197Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 2 1 10366 15607 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999935930292158 0.99964307871082 0.999998377896754 0.666666666666666 0.0942993240502461 0.991596241340387 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.50559521512637 0.0191855877809429 118.086077597882 1 610 2512 False False 3.01119043025274 0.156729426968348 177.474331043773 9.64599209028648e-05 2.44215077354346e-06 0.000537321795461189 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 59.8138891519084 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance No change no 1 +Streptomycin gid p.Arg206fs gid_p.Arg206fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Arg206* gid_p.Arg206* 1 stop_gained (see "Genomic_coordinates" sheet) 1 8 7 1 9 2 10359 15606 0.000868055555555555 0.000397004661559041 0.00164719739830421 0.999871860584315 0.999537193839207 0.999984481345552 0.818181818181818 0.482244147639827 0.97716880170004 0.875 0.473490329124793 0.996840276468748 0.777777777777777 0.399906426283687 0.971855026522101 10.5456125108601 1.35442891605515 474.232598408908 0.00838908532886469 64 2512 False False 6.77932232841007 1.4027122325702 64.548999635819 0.000675284584217634 0.000271541155781981 0.00139084623306823 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 6 1 8 2 7728 11872 0.00103412616339193 0.000446564649135067 0.00203661849802302 0.999831564763348 0.99939168785815 0.999979601060482 0.8 0.443904537692358 0.974789273673166 0.857142857142857 0.421276802956804 0.996389703138099 0.75 0.349144205587175 0.968145973750055 9.21739130434782 1.11787191064274 423.140900083386 0.0174358049224863 64 2071 False False 0 0 0 0 0 0 0 6.14492753623188 1.22574646110428 59.4356755260654 0.000775795190069821 0.000284754680122827 0.00168780896655335 0.999831564763348 0.99939168785815 0.999979601060482 3 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Arg207His gid_p.Arg207His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance No change no 1 +Streptomycin gid p.Arg20Gln gid_p.Arg20Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Arg20Gly gid_p.Arg20Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 10368 15604 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.28044779470556 0.155697794255122 153.5 2512 False False 0 0 2.28044779470556 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.71438150990605 0.283358886007265 193.5 2071 False False 0 0 0 0 0 0 0 0 0 3.71438150990605 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 2 3) Uncertain significance No change no 1 +Streptomycin gid p.Arg20Pro gid_p.Arg20Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 17 4 13 5 14 10363 15594 0.000482253086419753 0.000156604214122162 0.00112505595550109 0.99910302409021 0.99849548434986 0.999509530910458 0.263157894736842 0.0914657849076665 0.512029345345872 0.235294117647058 0.0681077404373566 0.49899327320458 0.222222222222222 0.0640920477176664 0.47637276573648 0.463008187412317 0.109945298662795 1.49929376156139 0.218018115878449 207 2512 False False 0.537420217532154 0.151443766603707 1.57966239109767 0.000385839683611459 0.000105138014297713 0.000987605477659245 0.99910302409021 0.99849548434986 0.999509530910458 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 13 3 10 3 10 7733 11864 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 0.999157823816742 0.998451755191613 0.9995960722577 0.23076923076923 0.0503810734911515 0.53813153923404 0.23076923076923 0.0503810734911515 0.53813153923404 0.23076923076923 0.0503810734911515 0.53813153923404 0.460261218155955 0.0813712613668843 1.78838261064702 0.269420208716512 172 2071 False False 0 0 0 0 0 0 0 0.460261218155955 0.0813712613668843 1.78838261064702 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 0.999157823816742 0.998451755191613 0.9995960722577 52 3) Uncertain significance No change no 1 +Streptomycin gid p.Arg213* gid_p.Arg213* 1 stop_gained (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1645 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1358 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Arg217Leu gid_p.Arg217Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1635 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1346 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Arg217Trp gid_p.Arg217Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 13 3) Uncertain significance No change no 1 +Streptomycin gid p.Arg21fs gid_p.Arg21fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 1 1 2 1 10366 15607 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999935930292158 0.99964307871082 0.999998377896754 0.666666666666666 0.0942993240502461 0.991596241340387 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.50559521512637 0.0191855877809429 118.086077597882 1 610 2512 False False 3.01119043025274 0.156729426968348 177.474331043773 9.64599209028648e-05 2.44215077354346e-06 0.000537321795461189 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.53497091144149 0.0195519049186736 120.390152361053 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 5 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Arg21Pro gid_p.Arg21Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 2 3 2 5 10366 15603 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999679651460789 0.999252573060182 0.999895975781355 0.285714285714285 0.0366925661760855 0.709579136262657 0.4 0.0527449505263169 0.853367200365326 0.285714285714285 0.0366925661760855 0.709579136262657 1.0034728921474 0.0837733234334363 8.76258826825732 1 973.5 2512 False False 0.602083735288443 0.0572994001432256 3.67859568857157 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999679651460789 0.999252573060182 0.999895975781355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 3 7735 11871 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999747347145022 0.999261820436506 0.999947893876346 0.25 0.00630946320970987 0.805879550316756 0.5 0.012579117093425 0.987420882906574 0.25 0.00630946320970987 0.805879550316756 1.53471234647705 0.0195486113582122 120.369894521531 1 806.5 2071 False False 0 0 0 0 0 0 0 0.511570782159017 0.0097482170621519 6.37282132403124 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999747347145022 0.999261820436506 0.999947893876346 7 3) Uncertain significance No change no 1 +Streptomycin gid p.Arg21Trp gid_p.Arg21Trp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 5 0 10363 15608 0.000482253086419753 0.000156604214122162 0.00112505595550109 1 0.99976368249849 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 1650 2512 False False Inf 1.37979907306709 Inf 0 0 0.000355903017804084 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 5 0 7731 11874 0.000646328852119958 0.0002098934625097 0.00150766595359595 1 0.999689379610589 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 1365 2071 False False 0 0 0 0 0 0 0 Inf 1.40693962335604 Inf 0 0 0.000477040423209609 1 0.999689379610589 1 7 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Arg33fs gid_p.Arg33fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1580 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1301 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Arg33Pro gid_p.Arg33Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 58.6540000158548 1 973.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance No change no 1 +Streptomycin gid p.Arg33Trp gid_p.Arg33Trp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1566 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1287 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 2 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Arg39Cys gid_p.Arg39Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Streptomycin gid p.Arg39fs gid_p.Arg39fs 1 frameshift (see "Genomic_coordinates" sheet) 1 133 80 53 130 69 10238 15539 0.0125385802469135 0.0104862897608918 0.014871012180337 0.995579190158892 0.994408468606292 0.996558766554082 0.653266331658291 0.582721802667703 0.719167080461418 0.601503759398496 0.513042960623009 0.685340388332454 0.536912751677852 0.453453950206438 0.618874519938574 2.29098401441909 1.59752638484789 3.30882149162526 2.85691764974066e-06 26 2512 True False 2.8595796846644 2.11698236378412 3.89107380280866 0.00775344058926148 0.00615264502205555 0.00964066666567464 0.995579190158892 0.994408468606292 0.996558766554082 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 87 51 36 91 49 7645 11825 0.0117631851085832 0.00948126403229829 0.0144231979007644 0.995873336702038 0.99454795955699 0.996945559195879 0.65 0.56488880404448 0.728615682348505 0.586206896551724 0.475539279809784 0.690833708227429 0.51 0.408036329155453 0.611355834838362 2.19124700239808 1.40092666628846 3.4594415981396 0.000369519468660568 35 2071 True False 0 0 0 0 0 0 0 2.87255909558067 2.00537930762442 4.15791929248473 0.00662681912681912 0.00493796621357299 0.00870394649397476 0.995873336702038 0.99454795955699 0.996945559195879 179 1) Assoc w R UP from AwRI to AwR yes 4 +Streptomycin gid p.Arg43fs gid_p.Arg43fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 58.6634076928655 1 973.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 59.8138891519084 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Arg47Gln gid_p.Arg47Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 11 8 3 8 3 10360 15605 0.000771604938271604 0.00033318123262376 0.00151980017311994 0.999807790876473 0.99943838714673 0.999960360103688 0.727272727272727 0.390257440427578 0.939782265827093 0.727272727272727 0.390257440427578 0.939782265827093 0.727272727272727 0.390257440427578 0.939782265827093 4.01673101673101 0.963737635015375 23.5108095728016 0.0325346166681188 92 2512 False False 4.01673101673101 0.963737635015375 23.5108095728016 0.000771604938271604 0.00033318123262376 0.00151980017311994 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 8 3 8 3 7728 11871 0.00103412616339193 0.000446564649135067 0.00203661849802302 0.999747347145022 0.999261820436506 0.999947893876346 0.727272727272727 0.390257440427578 0.939782265827093 0.727272727272727 0.390257440427578 0.939782265827093 0.727272727272727 0.390257440427578 0.939782265827093 4.09627329192546 0.982688710482773 23.9778421336991 0.0307662636100664 72 2071 False False 0 0 0 0 0 0 0 4.09627329192546 0.982688710482773 23.9778421336991 0.00103412616339193 0.000446564649135067 0.00203661849802302 0.999747347145022 0.999261820436506 0.999947893876346 1 3) Uncertain significance No change no 1 +Streptomycin gid p.Arg47Leu gid_p.Arg47Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 2 1 10366 15607 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999935930292158 0.99964307871082 0.999998377896754 0.666666666666666 0.0942993240502461 0.991596241340387 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.50559521512637 0.0191855877809429 118.086077597882 1 610 2512 False False 3.01119043025274 0.156729426968348 177.474331043773 9.64599209028648e-05 2.44215077354346e-06 0.000537321795461189 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.53497091144149 0.0195519049186736 120.390152361053 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 8 3) Uncertain significance No change no 1 +Streptomycin gid p.Arg47Pro gid_p.Arg47Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Arg47Trp gid_p.Arg47Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 11 3 8 6 9 10362 15599 0.000578703703703703 0.000212402724453782 0.00125916554902567 0.99942337262942 0.998905665124108 0.999736296428239 0.4 0.163364323859513 0.677130233793718 0.272727272727272 0.0602177341729066 0.609742559572421 0.25 0.0548606445279927 0.571858461878189 0.564526635784597 0.096430907699602 2.35281991888468 0.542850581263838 563 2512 False False 1.0036029080615 0.293857261692086 3.15841575964045 0.000289435600578871 5.96925569151148e-05 0.000845618353258805 0.99942337262942 0.998905665124108 0.999736296428239 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 2 2 5 3 7731 11871 0.000646328852119958 0.0002098934625097 0.00150766595359595 0.999747347145022 0.999261820436506 0.999947893876346 0.625 0.244863216366551 0.914766585862746 0.5 0.067585986488543 0.932414013511457 0.4 0.0527449505263169 0.853367200365326 1.53550640279394 0.111262754962502 21.1847539367417 0.649606062404596 482 2071 False False 0 0 0 0 0 0 0 2.55917733798991 0.497713634211278 16.4842738218502 0.000258631837579206 3.13230502042936e-05 0.00093395156507162 0.999747347145022 0.999261820436506 0.999947893876346 39 3) Uncertain significance No change no 1 +Streptomycin gid p.Arg61Pro gid_p.Arg61Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1587 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1307 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Arg64fs gid_p.Arg64fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Arg64Pro gid_p.Arg64Pro 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 1 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0386035211949905 Inf 0.399114533205004 308.5 2512 False False Inf 0.282736080598822 Inf 9.64599209028648e-05 2.44215077354346e-06 0.000537321795461189 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0393613144801391 Inf 0.394461726758121 237.5 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0.000129282482223658 3.27314370392442e-06 0.000720103058325324 1 0.999689379610589 1 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Arg64Trp gid_p.Arg64Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.282736080598822 Inf 0.159301643065502 181.5 2512 False False Inf 0.282736080598822 Inf 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.288279755767314 Inf 0.155612234482449 125.5 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 2 3) Uncertain significance No change no 1 +Streptomycin gid p.Arg83_Glu92del gid_p.Arg83_Glu92del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Streptomycin gid p.Arg83dup gid_p.Arg83dup 1 inframe_insertion (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.282736080598822 Inf 0.159301643065502 181.5 2512 False False Inf 0.282736080598822 Inf 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Streptomycin gid p.Arg83fs gid_p.Arg83fs 1 frameshift (see "Genomic_coordinates" sheet) 1 3 2 1 2 2 10366 15606 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999871860584315 0.999537193839207 0.999984481345552 0.5 0.067585986488543 0.932414013511457 0.666666666666666 0.0942993240502461 0.991596241340387 0.5 0.067585986488543 0.932414013511457 3.01099749180011 0.156719383570063 177.462973865319 0.56767458379113 572 2512 False False 1.50549874590005 0.10909391082996 20.7696540777406 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 2 1 2 2 7734 11872 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999831564763348 0.99939168785815 0.999979601060482 0.5 0.067585986488543 0.932414013511457 0.666666666666666 0.0942993240502461 0.991596241340387 0.5 0.067585986488543 0.932414013511457 3.07008016550297 0.159786167919495 180.944517163684 0.566067500528098 478 2071 False False 0 0 0 0 0 0 0 1.53504008275148 0.111228967362952 21.1783159842378 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999831564763348 0.99939168785815 0.999979601060482 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Arg83Gln gid_p.Arg83Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.282736080598822 Inf 0.159301643065502 181.5 2512 False False Inf 0.282736080598822 Inf 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Arg83Gly gid_p.Arg83Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 4 2 6 4 10362 15604 0.000578703703703703 0.000212402724453782 0.00125916554902567 0.999743721168631 0.999343955596995 0.999930168370675 0.6 0.262378076606945 0.878447741880172 0.666666666666666 0.222778095503512 0.956728131707258 0.5 0.157012770487058 0.842987229512941 3.01177378884385 0.431531238337958 33.3063360924483 0.225011042789692 212 2512 False False 2.25883034163288 0.535491434983611 10.8863434801125 0.000385876905267219 0.000105148157815303 0.000987700722510407 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 1 0.025 1 0.333333333333333 0.00840375865961264 0.905700675949754 Inf 0.0393495972922721 Inf 0.39453284373725 344.5 2071 False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 8 3) Uncertain significance No change no 1 +Streptomycin gid p.Arg83Leu gid_p.Arg83Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 10365 15608 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 1 0.99976368249849 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1651 2512 False False Inf 0.622129167636411 Inf 0 0 0.000355834356021348 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Streptomycin gid p.Arg83Pro gid_p.Arg83Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 6 3 7 3 10361 15605 0.000675154320987654 0.000271488767107418 0.00139057803317028 0.999807790876473 0.99943838714673 0.999960360103688 0.7 0.347547149940002 0.933260488822265 0.666666666666666 0.29929505620854 0.925145368580308 0.666666666666666 0.29929505620854 0.925145368580308 3.01225750410192 0.643115914947119 18.6170129509256 0.169556578150017 205 2512 False False 3.51430042145224 0.802019002880655 21.0638674909524 0.000578759525417189 0.000212423215569688 0.00125928696667465 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 6 3 7 3 7729 11871 0.000904860392967942 0.000363875741427306 0.00186346392020999 0.999747347145022 0.999261820436506 0.999947893876346 0.7 0.347547149940002 0.933260488822265 0.666666666666666 0.29929505620854 0.925145368580308 0.666666666666666 0.29929505620854 0.925145368580308 3.07180747832837 0.655755283058336 18.9861465880574 0.168333083304493 164 2071 False False 0 0 0 0 0 0 0 3.5837753913831 0.81778515516938 21.4815595723006 0.000775694893341952 0.000284717859669266 0.00168759086201426 0.999747347145022 0.999261820436506 0.999947893876346 6 3) Uncertain significance No change no 1 +Streptomycin gid p.Arg83Trp gid_p.Arg83Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.50544998553101 0.0191837380556942 118.074698097101 1 973.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 20 3) Uncertain significance No change no 1 +Streptomycin gid p.Arg96Cys gid_p.Arg96Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 5 2 7 5 10361 15603 0.000675154320987654 0.000271488767107418 0.00139057803317028 0.999679651460789 0.999252573060182 0.999895975781355 0.583333333333333 0.276669685682105 0.848347770191569 0.714285714285714 0.290420863737342 0.963307433823914 0.5 0.187086028447398 0.812913971552601 3.76483930122575 0.616187529873026 39.5416494134817 0.123655354087607 136 2512 False False 2.10831000868642 0.575819720346433 8.4262016522379 0.000482346131584024 0.000156634432561448 0.00112527295223035 0.999679651460789 0.999252573060182 0.999895975781355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 4 1 5 3 7731 11871 0.000646328852119958 0.0002098934625097 0.00150766595359595 0.999747347145022 0.999261820436506 0.999947893876346 0.625 0.244863216366551 0.914766585862746 0.8 0.28358206388191 0.994949236620532 0.571428571428571 0.184051567640083 0.901011721557492 6.14202561117578 0.60760710147201 302.03677002801 0.0828579871576785 105 2071 False False 0 0 0 0 0 0 0 2.55917733798991 0.497713634211278 16.4842738218502 0.000517129928894634 0.000140917901974878 0.00132352387806833 0.999747347145022 0.999261820436506 0.999947893876346 6 3) Uncertain significance No change no 1 +Streptomycin gid p.Arg96His gid_p.Arg96His 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 2 3 2 3 10366 15605 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999807790876473 0.99943838714673 0.999960360103688 0.4 0.0527449505263169 0.853367200365326 0.4 0.0527449505263169 0.853367200365326 0.4 0.0527449505263169 0.853367200365326 1.00360151778249 0.0837840645585397 8.76371184924575 1 973.5 2512 False False 1.00360151778249 0.0837840645585397 8.76371184924575 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 2 3 2 3 7734 11871 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999747347145022 0.999261820436506 0.999947893876346 0.4 0.0527449505263169 0.853367200365326 0.4 0.0527449505263169 0.853367200365326 0.4 0.0527449505263169 0.853367200365326 1.02327385570209 0.0854221600622099 8.93608975066686 1 512 2071 False False 0 0 0 0 0 0 0 1.02327385570209 0.0854221600622099 8.93608975066686 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999747347145022 0.999261820436506 0.999947893876346 1 3) Uncertain significance No change no 1 +Streptomycin gid p.Arg96Leu gid_p.Arg96Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 14 9 5 12 7 10356 15601 0.0011574074074074 0.000598187780713703 0.00202088408121616 0.999551512045105 0.999076163117038 0.999819666176692 0.631578947368421 0.383577923314405 0.8371141278449 0.642857142857142 0.351380110615991 0.87240157014084 0.5625 0.298776899083177 0.802465859467332 2.71164542294322 0.815804532917215 10.300552378468 0.0977735571980686 131 2512 False False 2.58251945042211 0.936994340962654 7.74421040742579 0.000868306801736613 0.000397119590385432 0.00164767396988471 0.999551512045105 0.999076163117038 0.999819666176692 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 13 3) Uncertain significance No change no 1 +Streptomycin gid p.Arg96Pro gid_p.Arg96Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.282736080598822 Inf 0.159301643065502 181.5 2512 False False Inf 0.282736080598822 Inf 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 3) Uncertain significance No change no 1 +Streptomycin gid p.Arg97Cys gid_p.Arg97Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1590 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1310 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Arg97fs gid_p.Arg97fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Arg97His gid_p.Arg97His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 3 0 10365 15608 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 1 0.99976368249849 1 1 0.292401773821286 1 1 0.025 1 1 0.025 1 Inf 0.0386072452937345 Inf 0.399091399091399 297.5 2512 False False Inf 0.622129167636411 Inf 9.64692263168049e-05 2.44238636565143e-06 0.000537373619049235 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0393613144801391 Inf 0.394461726758121 237.5 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0.000129282482223658 3.27314370392442e-06 0.000720103058325324 1 0.999689379610589 1 8 3) Uncertain significance No change no 1 +Streptomycin gid p.Arg97Leu gid_p.Arg97Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 2 2 2 2 10366 15606 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999871860584315 0.999537193839207 0.999984481345552 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 1.50549874590005 0.10909391082996 20.7696540777406 0.653642588225642 583.5 2512 False False 1.50549874590005 0.10909391082996 20.7696540777406 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.53497091144149 0.0195519049186736 120.390152361053 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 3 3) Uncertain significance No change no 1 +Streptomycin gid p.Asn194Asp gid_p.Asn194Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1571 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1291 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Asn194fs gid_p.Asn194fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Asn51Asp gid_p.Asn51Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 6 1 10362 15607 0.000578703703703703 0.000212402724453782 0.00125916554902567 0.999935930292158 0.99964307871082 0.999998377896754 0.857142857142857 0.421276802956804 0.996389703138099 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0386159476001563 Inf 0.399037350789372 293 2512 False False 9.03705848291835 1.09610816025756 414.873240547969 9.64971533339766e-05 2.44309341478262e-06 0.000537529149810079 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 6 1 7730 11873 0.00077559462254395 0.000284681048736677 0.00168737281383633 0.999915782381674 0.999530859783396 0.999997867796783 0.857142857142857 0.421276802956804 0.996389703138099 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0393783635006063 Inf 0.394358294225668 221 2071 False False 0 0 0 0 0 0 0 9.21578266494178 1.11767707530695 423.06722176879 0.000129349372655542 3.27483721749028e-06 0.000720475527685032 0.999915782381674 0.999530859783396 0.999997867796783 5 3) Uncertain significance No change no 1 +Streptomycin gid p.Asn51His gid_p.Asn51His 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1674 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1384 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Asn51Lys gid_p.Asn51Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 5 0 9 7 10359 15601 0.000868055555555555 0.000397004661559041 0.00164719739830421 0.999551512045105 0.999076163117038 0.999819666176692 0.5625 0.298776899083177 0.802465859467332 1 0.478176249895018 1 0.416666666666666 0.15165222980843 0.723330314317894 Inf 1.37971267700235 Inf 0.0101261313394626 69 2512 False False 1.93632865830954 0.641428173167175 6.12008165644919 0.000482439212659204 0.00015666466266492 0.00112549003268285 0.999551512045105 0.999076163117038 0.999819666176692 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 5 0 7 1 7729 11873 0.000904860392967942 0.000363875741427306 0.00186346392020999 0.999915782381674 0.999530859783396 0.999997867796783 0.875 0.473490329124793 0.996840276468748 1 0.478176249895018 1 0.833333333333333 0.358765421002325 0.99578925548551 Inf 1.40718502210477 Inf 0.00954168253598767 57 2071 False False 0 0 0 0 0 0 0 10.7531375339629 1.38092189761868 483.549887206656 0.000646495991724851 0.000209947748965095 0.00150805566549033 0.999915782381674 0.999530859783396 0.999997867796783 20 3) Uncertain significance No change no 1 +Streptomycin gid p.Asn51Thr gid_p.Asn51Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.752676762805054 0.0127620362920002 14.460605698152 1 1332 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.767420814479638 0.0130114906060525 14.7444541307454 1 806.5 2071 False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 5 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Asp107fs gid_p.Asp107fs 1 frameshift (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 10368 15604 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.28044779470556 0.155697794255122 153.5 2512 False False 0 0 2.28044779470556 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 27 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Asp107Gly gid_p.Asp107Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Asp107His gid_p.Asp107His 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1675 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1385 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Asp132Glu gid_p.Asp132Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 1 0.025 1 0.333333333333333 0.00840375865961264 0.905700675949754 Inf 0.0385948515967487 Inf 0.399168399168399 414 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 1 0.025 1 0.333333333333333 0.00840375865961264 0.905700675949754 Inf 0.0393495972922721 Inf 0.39453284373725 344.5 2071 False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 3 3) Uncertain significance No change no 1 +Streptomycin gid p.Asp132Gly gid_p.Asp132Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.01513406993295 0.520321755085951 445 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.17205443383047 0.522230766108178 361 2071 False False 0 0 0 0 0 0 0 0 0 3.71438150990605 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Asp132His gid_p.Asp132His 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1630 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Asp132Tyr gid_p.Asp132Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 2 1 14 1 10354 15607 0.0013503086419753 0.00073841672613154 0.00226455162408295 0.999935930292158 0.99964307871082 0.999998377896754 0.933333333333333 0.680515433421696 0.998313569758647 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 3.01468031678578 0.156911063397433 177.679773149853 0.567570449876543 565 2512 False False 21.1027622175004 3.20947766402083 888.650594417532 0.000193124758594051 2.33891599924929e-05 0.000697457072235808 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Asp143Ala gid_p.Asp143Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1605 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1321 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 3 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Asp169Gly gid_p.Asp169Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 3 3) Uncertain significance No change no 1 +Streptomycin gid p.Asp169His gid_p.Asp169His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Asp185Asn gid_p.Asp185Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 3 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Asp185fs gid_p.Asp185fs 1 frameshift (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.6429945931141 0.280491932584249 243 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.71438150990605 0.283358886007265 193.5 2071 False False 0 0 0 0 0 0 0 0 0 3.71438150990605 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Asp46fs gid_p.Asp46fs 1 frameshift (see "Genomic_coordinates" sheet) 1 7 6 1 6 1 10362 15607 0.000578703703703703 0.000212402724453782 0.00125916554902567 0.999935930292158 0.99964307871082 0.999998377896754 0.857142857142857 0.421276802956804 0.996389703138099 0.857142857142857 0.421276802956804 0.996389703138099 0.857142857142857 0.421276802956804 0.996389703138099 9.03705848291835 1.09610816025756 414.873240547969 0.0186072947696771 78 2512 False False 9.03705848291835 1.09610816025756 414.873240547969 0.000578703703703703 0.000212402724453782 0.00125916554902567 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 4 1 4 1 7732 11873 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.999915782381674 0.999530859783396 0.999997867796783 0.8 0.28358206388191 0.994949236620532 0.8 0.28358206388191 0.994949236620532 0.8 0.28358206388191 0.994949236620532 6.14226590791515 0.607630898004113 302.048561734113 0.0828510346178796 103 2071 False False 0 0 0 0 0 0 0 6.14226590791515 0.607630898004113 302.048561734113 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.999915782381674 0.999530859783396 0.999997867796783 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Asp63fs gid_p.Asp63fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.282736080598822 Inf 0.159301643065502 181.5 2512 False False Inf 0.282736080598822 Inf 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.288279755767314 Inf 0.155612234482449 125.5 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Asp63His gid_p.Asp63His 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 0 1 2 1 10366 15607 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999935930292158 0.99964307871082 0.999998377896754 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 58.6690617185945 1 973.5 2512 False False 3.01119043025274 0.156729426968348 177.474331043773 0 0 0.000355800035063835 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 0 1 2 1 7734 11873 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999915782381674 0.999530859783396 0.999997867796783 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 59.821615810862 1 806.5 2071 False False 0 0 0 0 0 0 0 3.07033876389966 0.159799628612092 180.959738606129 0 0 0.000476855424503066 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Asp63Tyr gid_p.Asp63Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 3 0 4 0 10364 15608 0.000385802469135802 0.000105127872737001 0.000987510251175401 1 0.99976368249849 1 1 0.397635364383525 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.622189184020377 Inf 0.063564860983169 112 2512 False False Inf 0.993868422549659 Inf 0.000289379762708594 5.96810402691469e-05 0.000845455262078775 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 3 0 4 0 7732 11874 0.000517063081695967 0.000140899683864147 0.00132335286075948 1 0.999689379610589 1 1 0.397635364383525 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.63442029495942 Inf 0.0613638503800333 92 2071 False False 0 0 0 0 0 0 0 Inf 1.01342344657205 Inf 0.000387847446670976 7.99906106240067e-05 0.00113303233742371 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Asp67_Gly71del gid_p.Asp67_Gly71del 1 inframe_deletion (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1576 2512 False False Inf 0.282736080598822 Inf 0 0 0.000355800035063835 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1296 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0 0 0.000476855424503066 1 0.999689379610589 1 NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Streptomycin gid p.Asp67Ala gid_p.Asp67Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 2 1 10366 15607 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999935930292158 0.99964307871082 0.999998377896754 0.666666666666666 0.0942993240502461 0.991596241340387 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.50559521512637 0.0191855877809429 118.086077597882 1 610 2512 False False 3.01119043025274 0.156729426968348 177.474331043773 9.64599209028648e-05 2.44215077354346e-06 0.000537321795461189 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 59.8138891519084 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 4 3) Uncertain significance No change no 1 +Streptomycin gid p.Asp67Asn gid_p.Asp67Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 5 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Asp67fs gid_p.Asp67fs 1 frameshift (see "Genomic_coordinates" sheet) 1 3 1 2 2 2 10366 15606 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999871860584315 0.999537193839207 0.999984481345552 0.5 0.067585986488543 0.932414013511457 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.752749372950029 0.0127632667350056 14.4620006025996 1 973.5 2512 False False 1.50549874590005 0.10909391082996 20.7696540777406 9.64599209028648e-05 2.44215077354346e-06 0.000537321795461189 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 2 2 7734 11872 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999831564763348 0.99939168785815 0.999979601060482 0.5 0.067585986488543 0.932414013511457 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.767520041375743 0.0130131719863744 14.7463604652951 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53504008275148 0.111228967362952 21.1783159842378 0.000129282482223658 3.27314370392442e-06 0.000720103058325324 0.999831564763348 0.99939168785815 0.999979601060482 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Asp67Glu gid_p.Asp67Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.50544998553101 0.0191837380556942 118.074698097101 1 973.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.53497091144149 0.0195519049186736 120.390152361053 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance No change no 1 +Streptomycin gid p.Asp67Gly gid_p.Asp67Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 16 7 9 67 11 10301 15597 0.00646219135802469 0.00501151635309248 0.00819958899142936 0.999295233213736 0.998739328260189 0.999648132128855 0.858974358974358 0.761661009337314 0.927442462144396 0.4375 0.197534140532667 0.701223100916822 0.388888888888888 0.172985854789751 0.642548794106937 1.17765265508203 0.372594689680301 3.55483063376795 0.800904183957703 599 2512 False False 9.22239676642161 4.83538574554501 19.3613044994033 0.000679084206441598 0.00027306927196858 0.00139866928619376 0.999295233213736 0.998739328260189 0.999648132128855 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 2 1 7 1 7729 11873 0.000904860392967942 0.000363875741427306 0.00186346392020999 0.999915782381674 0.999530859783396 0.999997867796783 0.875 0.473490329124793 0.996840276468748 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 3.07232500970371 0.159902995336577 181.076661150658 0.566009363066891 469 2071 False False 0 0 0 0 0 0 0 10.7531375339629 1.38092189761868 483.549887206656 0.000258698745311085 3.1331153835274e-05 0.000934193095527727 0.999915782381674 0.999530859783396 0.999997867796783 21 3) Uncertain significance No change no 1 +Streptomycin gid p.Asp67His gid_p.Asp67His 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 8 0 9 1 10359 15607 0.000868055555555555 0.000397004661559041 0.00164719739830421 0.999935930292158 0.99964307871082 0.999998377896754 0.9 0.554983882971804 0.997471421455538 1 0.63058335244718 1 0.888888888888888 0.517503485082663 0.9971908632534 Inf 2.5707808356564 Inf 0.000642997159531794 45 2512 True False 13.5595134665508 1.87836425995922 592.705115386917 0.000771679367222918 0.000333213376758345 0.00151994671802226 0.999935930292158 0.99964307871082 0.999998377896754 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance 1 6 6 0 7 0 7729 11874 0.000904860392967942 0.000363875741427306 0.00186346392020999 1 0.999689379610589 1 1 0.590383602774996 1 1 0.540741873560099 1 1 0.540741873560099 1 Inf 1.80822012913135 Inf 0.00376286880071648 46 2071 False False 0 0 0 0 0 0 0 Inf 2.21347144138593 Inf 0.000775694893341952 0.000284717859669266 0.00168759086201426 1 0.999689379610589 1 3 Evidence from ALL dataset only 2) Assoc w R - Interim UP from Uncertain to AwRI yes ALL only 4 +Streptomycin gid p.Asp85Ala gid_p.Asp85Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 4 1 4 1 10364 15607 0.000385802469135802 0.000105127872737001 0.000987510251175401 0.999935930292158 0.99964307871082 0.999998377896754 0.8 0.28358206388191 0.994949236620532 0.8 0.28358206388191 0.994949236620532 0.8 0.28358206388191 0.994949236620532 6.02354303357776 0.595936886271208 296.214625622934 0.0863587477374473 124 2512 False False 6.02354303357776 0.595936886271208 296.214625622934 0.000385802469135802 0.000105127872737001 0.000987510251175401 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 4 1 4 1 7732 11873 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.999915782381674 0.999530859783396 0.999997867796783 0.8 0.28358206388191 0.994949236620532 0.8 0.28358206388191 0.994949236620532 0.8 0.28358206388191 0.994949236620532 6.14226590791515 0.607630898004113 302.048561734113 0.0828510346178796 103 2071 False False 0 0 0 0 0 0 0 6.14226590791515 0.607630898004113 302.048561734113 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance No change no 1 +Streptomycin gid p.Asp85Asn gid_p.Asp85Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Asp85Glu gid_p.Asp85Glu 1 missense_variant (see "Genomic_coordinates" sheet) 2 4 0 4 1 4 10367 15604 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999743721168631 0.999343955596995 0.999930168370675 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.28066788567474 0.155711983833633 162 2512 False False 0.376290151442075 0.00764455959995544 3.80334957923739 0 0 0.000355765720726338 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 4 0 4 1 4 7735 11870 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999663129526697 0.999137704464366 0.999908206750254 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.32543092899395 0.158624932919193 149.5 2071 False False 0 0 0 0 0 0 0 0.383645765998707 0.00779364023519555 3.87797408017955 0 0 0.000476793790149404 0.999663129526697 0.999137704464366 0.999908206750254 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Asp85Gly gid_p.Asp85Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 3 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Asp85His gid_p.Asp85His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Cys191Arg gid_p.Cys191Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Cys191fs gid_p.Cys191fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0386035211949905 Inf 0.399114533205004 308.5 2512 False False Inf 0.282736080598822 Inf 9.64599209028648e-05 2.44215077354346e-06 0.000537321795461189 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0393613144801391 Inf 0.394461726758121 237.5 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0.000129282482223658 3.27314370392442e-06 0.000720103058325324 1 0.999689379610589 1 3 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Cys191Phe gid_p.Cys191Phe 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 1 10366 15607 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999935930292158 0.99964307871082 0.999998377896754 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 1572 2512 False False 3.01119043025274 0.156729426968348 177.474331043773 0 0 0.000355800035063835 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1292 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance No change no 1 +Streptomycin gid p.Cys191Trp gid_p.Cys191Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.752676762805054 0.0127620362920002 14.460605698152 1 1332 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.767420814479638 0.0130114906060525 14.7444541307454 1 806.5 2071 False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 3 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Cys191Tyr gid_p.Cys191Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.752676762805054 0.0127620362920002 14.460605698152 1 1332 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.767420814479638 0.0130114906060525 14.7444541307454 1 806.5 2071 False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 3 3) Uncertain significance No change no 1 +Streptomycin gid p.Cys52Arg gid_p.Cys52Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 10368 15604 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.64276114479861 0.280482632628927 227 2512 False False 0 0 2.28044779470556 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 7736 11870 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.71406862449918 0.283346149162266 180.5 2071 False False 0 0 0 0 0 0 0 0 0 2.32513012450998 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 8 3) Uncertain significance No change no 1 +Streptomycin gid p.Cys52Phe gid_p.Cys52Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 6 3) Uncertain significance No change no 1 +Streptomycin gid p.Cys52* gid_p.Cys52* 1 stop_gained (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Cys52Trp gid_p.Cys52Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.01513406993295 0.520321755085951 445 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.17205443383047 0.522230766108178 361 2071 False False 0 0 0 0 0 0 0 0 0 3.71438150990605 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 3 3) Uncertain significance No change no 1 +Streptomycin gid p.Cys52Tyr gid_p.Cys52Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 2 1 2 1 10366 15607 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999935930292158 0.99964307871082 0.999998377896754 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 3.01119043025274 0.156729426968348 177.474331043773 0.567669114955046 570 2512 False False 3.01119043025274 0.156729426968348 177.474331043773 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 4 3) Uncertain significance No change no 1 +Streptomycin gid p.Gln125fs gid_p.Gln125fs 1 frameshift (see "Genomic_coordinates" sheet) 1 7 4 3 5 3 10363 15605 0.000482253086419753 0.000156604214122162 0.00112505595550109 0.999807790876473 0.99943838714673 0.999960360103688 0.625 0.244863216366551 0.914766585862746 0.571428571428571 0.184051567640083 0.901011721557492 0.571428571428571 0.184051567640083 0.901011721557492 2.00778410370227 0.339590695203767 13.7103768077507 0.447812577897195 423 2512 False False 2.50973012962784 0.48813575589439 16.1645252811411 0.000385839683611459 0.000105138014297713 0.000987605477659245 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 4 0 5 0 7731 11874 0.000646328852119958 0.0002098934625097 0.00150766595359595 1 0.999689379610589 1 1 0.478176249895018 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 1.01355450689052 Inf 0.0242000046484962 67 2071 False False 0 0 0 0 0 0 0 Inf 1.40693962335604 Inf 0.000517129928894634 0.000140917901974878 0.00132352387806833 1 0.999689379610589 1 3 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Gln125Glu gid_p.Gln125Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 10368 15604 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1657 2512 False False 0 0 2.28044779470556 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 7736 11870 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1368 2071 False False 0 0 0 0 0 0 0 0 0 2.32513012450998 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 1 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Gln125* gid_p.Gln125* 1 stop_gained (see "Genomic_coordinates" sheet) 1 45 32 13 87 20 10281 15588 0.0083912037037037 0.00672631300022704 0.0103403647893774 0.998718605843157 0.998021680992693 0.99921712098903 0.813084112149532 0.726192286531046 0.881926927876806 0.711111111111111 0.556854722914768 0.836337439554318 0.615384615384615 0.470184821842253 0.746953471013033 3.73217211734865 1.90405056276796 7.75156578209879 2.44826803096027e-05 31 2512 True False 6.59544791362707 4.0180467732405 11.3282699334265 0.0031028798603704 0.00212330616754824 0.00437754182132352 0.998718605843157 0.998021680992693 0.99921712098903 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 37 28 9 83 16 7653 11858 0.0107290589451913 0.0085544430126807 0.0132831539595622 0.998652518106788 0.997812693726175 0.999229607694274 0.838383838383838 0.7508536586334 0.904705911160838 0.756756756756756 0.588008307576086 0.882274825692892 0.636363636363636 0.477721496438625 0.775919859921276 4.82053515687384 2.20974299773031 11.6178473033181 1.02754601849041e-05 22 2071 True False 0 0 0 0 0 0 0 8.03781196916242 4.66442046898955 14.7246440353538 0.00364535867725556 0.00242363972508722 0.0052642809137995 0.998652518106788 0.997812693726175 0.999229607694274 73 Assoc w R 1) Assoc w R No change yes 1 +Streptomycin gid p.Gln127Glu gid_p.Gln127Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Streptomycin gid p.Gln127* gid_p.Gln127* 1 stop_gained (see "Genomic_coordinates" sheet) 1 14 7 7 9 9 10359 15599 0.000868055555555555 0.000397004661559041 0.00164719739830421 0.99942337262942 0.998905665124108 0.999736296428239 0.5 0.260190582895097 0.739809417104903 0.5 0.230360541448062 0.769639458551937 0.4375 0.197534140532667 0.701223100916822 1.50584033207838 0.450550845426781 5.03258009526676 0.586559881658663 576 2512 False False 1.50584033207838 0.529400161427175 4.28356281923136 0.000675284584217634 0.000271541155781981 0.00139084623306823 0.99942337262942 0.998905665124108 0.999736296428239 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 5 6 6 8 7730 11866 0.00077559462254395 0.000284681048736677 0.00168737281383633 0.999326259053394 0.998672895689377 0.999709083033384 0.428571428571428 0.176611089982117 0.711390599961692 0.454545454545454 0.167488094063707 0.766206402340654 0.384615384615384 0.13857933889016 0.684222397085936 1.27921517895644 0.308741577225691 5.03262242317242 0.761431568288179 504 2071 False False 0 0 0 0 0 0 0 1.1512936610608 0.329114894246618 3.78538806793166 0.000646412411118293 0.000209920602227715 0.00150786078436255 0.999326259053394 0.998672895689377 0.999709083033384 7 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Gln210fs gid_p.Gln210fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1567 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Gln210His gid_p.Gln210His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1583 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Gln87Arg gid_p.Gln87Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 4 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Gln87fs gid_p.Gln87fs 1 frameshift (see "Genomic_coordinates" sheet) 1 3 3 0 3 0 10365 15608 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 1 0.99976368249849 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.622129167636411 Inf 0.06357591560857 116 2512 False False Inf 0.622129167636411 Inf 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.288279755767314 Inf 0.155612234482449 125.5 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 9 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Gln87Glu gid_p.Gln87Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 9 10368 15599 0 0 0.000355731413006942 0.99942337262942 0.998905665124108 0.999736296428239 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1606 2512 False False 0 0 0.762426796904344 0 0 0.000355731413006942 0.99942337262942 0.998905665124108 0.999736296428239 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 7736 11868 0 0 0.000476732171726368 0.999494694290045 0.998900489118281 0.999814539856352 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1322 2071 False False 0 0 0 0 0 0 0 0 0 1.30338194607257 0 0 0.000476732171726368 0.999494694290045 0.998900489118281 0.999814539856352 28 3) Uncertain significance No change no 1 +Streptomycin gid p.Gln87Pro gid_p.Gln87Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Streptomycin gid p.Gln87* gid_p.Gln87* 1 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1555 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Glu103Ala gid_p.Glu103Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Glu103* gid_p.Glu103* 1 stop_gained (see "Genomic_coordinates" sheet) 1 12 9 3 9 3 10359 15605 0.000868055555555555 0.000397004661559041 0.00164719739830421 0.999807790876473 0.99943838714673 0.999960360103688 0.75 0.42814153812181 0.945139355472007 0.75 0.42814153812181 0.945139355472007 0.75 0.42814153812181 0.945139355472007 4.51925861569649 1.12742337387643 25.9566145270552 0.0172187931373968 76 2512 False False 4.51925861569649 1.12742337387643 25.9566145270552 0.000868055555555555 0.000397004661559041 0.00164719739830421 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 5 3 5 3 7731 11871 0.000646328852119958 0.0002098934625097 0.00150766595359595 0.999747347145022 0.999261820436506 0.999947893876346 0.625 0.244863216366551 0.914766585862746 0.625 0.244863216366551 0.914766585862746 0.625 0.244863216366551 0.914766585862746 2.55917733798991 0.497713634211278 16.4842738218502 0.277415922165083 174 2071 False False 0 0 0 0 0 0 0 2.55917733798991 0.497713634211278 16.4842738218502 0.000646328852119958 0.0002098934625097 0.00150766595359595 0.999747347145022 0.999261820436506 0.999947893876346 17 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Glu113Ala gid_p.Glu113Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Glu113Gln gid_p.Glu113Gln 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1641 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1353 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Glu120Ala gid_p.Glu120Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Glu120Asp gid_p.Glu120Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1676 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1386 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 1 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Glu120fs gid_p.Glu120fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 1 0.025 1 0.333333333333333 0.00840375865961264 0.905700675949754 Inf 0.0385948515967487 Inf 0.399168399168399 414 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0393529118200762 Inf 0.394512723749298 338.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Glu120Lys gid_p.Glu120Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1591 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1311 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Glu121Asp gid_p.Glu121Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 1 5 1 5 10367 15603 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999679651460789 0.999252573060182 0.999895975781355 0.166666666666666 0.00421074451448947 0.641234578997674 0.166666666666666 0.00421074451448947 0.641234578997674 0.166666666666666 0.00421074451448947 0.641234578997674 0.30101282916948 0.00636796908209055 2.69069235774657 0.412577015188174 417.5 2512 False False 0.30101282916948 0.00636796908209055 2.69069235774657 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999679651460789 0.999252573060182 0.999895975781355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 22 3) Uncertain significance No change no 1 +Streptomycin gid p.Glu121fs gid_p.Glu121fs 1 frameshift (see "Genomic_coordinates" sheet) 2 1 1 0 2 1 10366 15607 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999935930292158 0.99964307871082 0.999998377896754 0.666666666666666 0.0942993240502461 0.991596241340387 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0386010478475006 Inf 0.399129899129899 318 2512 False False 3.01119043025274 0.156729426968348 177.474331043773 9.64599209028648e-05 2.44215077354346e-06 0.000537321795461189 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Glu121Lys gid_p.Glu121Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1661 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1371 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Glu121* gid_p.Glu121* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Glu165Gly gid_p.Glu165Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Glu165* gid_p.Glu165* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Glu170Asp gid_p.Glu170Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 58.6596525903968 1 973.5 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 0 0 0.000355765720726338 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1338 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance No change no 1 +Streptomycin gid p.Glu170Gly gid_p.Glu170Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.50544998553101 0.0191837380556942 118.074698097101 1 973.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Glu170Lys gid_p.Glu170Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 2 2 15 9 10353 15599 0.00144675925925925 0.00080995915704588 0.00238508849276012 0.99942337262942 0.998905665124108 0.999736296428239 0.625 0.405936384007944 0.812007071803997 0.5 0.067585986488543 0.932414013511457 0.181818181818181 0.0228311982999596 0.517755852360172 1.5067130300396 0.109181897540477 20.7864178026977 0.653476077244753 578 2512 False False 2.51118838339933 1.02905810788647 6.51133797774 0.000193143408981168 2.33914188061968e-05 0.000697524409861959 0.99942337262942 0.998905665124108 0.999736296428239 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 13 8 7723 11866 0.00168045501551189 0.000895065386794453 0.00287191489837179 0.999326259053394 0.998672895689377 0.999709083033384 0.619047619047619 0.384354390378645 0.818928374459826 0.5 0.012579117093425 0.987420882906574 0.111111111111111 0.00280913674659921 0.482496514917337 1.53644956623073 0.0195707359039493 120.506016140154 1 512 2071 False False 0 0 0 0 0 0 0 2.49673054512495 0.958660095803044 6.95222542256325 0.000129466597617814 3.27780508685232e-06 0.000721128277069845 0.999326259053394 0.998672895689377 0.999709083033384 15 3) Uncertain significance No change no 1 +Streptomycin gid p.Glu170* gid_p.Glu170* 1 stop_gained (see "Genomic_coordinates" sheet) 1 2 1 1 2 2 10366 15606 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999871860584315 0.999537193839207 0.999984481345552 0.5 0.067585986488543 0.932414013511457 0.5 0.012579117093425 0.987420882906574 0.333333333333333 0.00840375865961264 0.905700675949754 1.50549874590005 0.019184358977771 118.078519203969 1 973.5 2512 False False 1.50549874590005 0.10909391082996 20.7696540777406 9.64599209028648e-05 2.44215077354346e-06 0.000537321795461189 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 59.8088564761233 1 806.5 2071 False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 0 0 0.000476793790149404 0.999831564763348 0.99939168785815 0.999979601060482 2 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Glu173Ala gid_p.Glu173Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1592 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1312 2071 False False 0 0 0 0 0 0 0 0 0 3.71438150990605 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 1 3) Uncertain significance No change no 1 +Streptomycin gid p.Glu173Gly gid_p.Glu173Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1581 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1302 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Glu173* gid_p.Glu173* 1 stop_gained (see "Genomic_coordinates" sheet) 1 13 4 9 4 10 10364 15598 0.000385802469135802 0.000105127872737001 0.000987510251175401 0.999359302921578 0.998822051949738 0.999692719453314 0.285714285714285 0.0838893183071275 0.581035257183661 0.307692307692307 0.0909203945720966 0.614261661750705 0.285714285714285 0.0838893183071275 0.581035257183661 0.668896607916291 0.150482064267952 2.39738286511922 0.58219702026231 574 2512 False False 0.602006947124662 0.137811447809861 2.08794685943142 0.000385802469135802 0.000105127872737001 0.000987510251175401 0.999359302921578 0.998822051949738 0.999692719453314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 13 4 9 4 10 7732 11864 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.999157823816742 0.998451755191613 0.9995960722577 0.285714285714285 0.0838893183071275 0.581035257183661 0.307692307692307 0.0909203945720966 0.614261661750705 0.285714285714285 0.0838893183071275 0.581035257183661 0.681956659194114 0.153408083698813 2.44449216858587 0.584658367122658 479 2071 False False 0 0 0 0 0 0 0 0.613760993274702 0.14045294063066 2.12901862852369 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.999157823816742 0.998451755191613 0.9995960722577 8 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Glu32Asp gid_p.Glu32Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 16 0 16 11 25 10357 15583 0.00106095679012345 0.000529741017552837 0.00189754996565939 0.998398257303946 0.997636413671316 0.998963176712956 0.305555555555555 0.163473984628493 0.481070630000079 0 0 0.205907214207822 0 0 0.137185171530712 0 0 0.390236668002542 0.000410929336870559 43 2512 True False 0.662017958868398 0.29389723294901 1.39554175048223 0 0 0.000356109162232076 0.998398257303946 0.997636413671316 0.998963176712956 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 15 0 15 9 24 7727 11850 0.00116339193381592 0.000532110502771461 0.00220732634615895 0.997978777160182 0.99699406380332 0.998704548393253 0.272727272727272 0.132996388710814 0.455238427760781 0 0 0.218019360910534 0 0 0.142473597722525 0 0 0.427768472915764 0.000773498233777202 37 2071 True False 0 0 0 0 0 0 0 0.575093826840947 0.235124047331509 1.28241372202129 0 0 0.00047728731155563 0.997978777160182 0.99699406380332 0.998704548393253 22 3) Uncertain significance No change no 1 +Streptomycin gid p.Glu32fs gid_p.Glu32fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 1 1 2 1 10366 15607 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999935930292158 0.99964307871082 0.999998377896754 0.666666666666666 0.0942993240502461 0.991596241340387 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.50559521512637 0.0191855877809429 118.086077597882 1 610 2512 False False 3.01119043025274 0.156729426968348 177.474331043773 9.64599209028648e-05 2.44215077354346e-06 0.000537321795461189 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 2 1 7734 11873 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999915782381674 0.999530859783396 0.999997867796783 0.666666666666666 0.0942993240502461 0.991596241340387 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.53516938194983 0.0195544326818075 120.405703250322 1 512 2071 False False 0 0 0 0 0 0 0 3.07033876389966 0.159799628612092 180.959738606129 0.000129282482223658 3.27314370392442e-06 0.000720103058325324 0.999915782381674 0.999530859783396 0.999997867796783 4 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Glu40Ala gid_p.Glu40Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 2 4 2 4 10366 15604 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999743721168631 0.999343955596995 0.999930168370675 0.333333333333333 0.0432718682927417 0.777221904496487 0.333333333333333 0.0432718682927417 0.777221904496487 0.333333333333333 0.0432718682927417 0.777221904496487 0.752652903723712 0.0680519547847045 5.25297485318028 1 973.5 2512 False False 0.752652903723712 0.0680519547847045 5.25297485318028 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 3 3) Uncertain significance No change no 1 +Streptomycin gid p.Glu40Gln gid_p.Glu40Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 3 1 10365 15607 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999935930292158 0.99964307871082 0.999998377896754 0.75 0.194120449683243 0.99369053679029 1 0.158113883008419 1 0.666666666666666 0.0942993240502461 0.991596241340387 Inf 0.282745237798141 Inf 0.159295442743639 172 2512 False False 4.51722141823444 0.362625225225282 236.854590713406 0.000192919841805729 2.33643418036207e-05 0.000696717215522511 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 1 7734 11873 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999915782381674 0.999530859783396 0.999997867796783 0.666666666666666 0.0942993240502461 0.991596241340387 1 0.158113883008419 1 0.666666666666666 0.0942993240502461 0.991596241340387 Inf 0.288255476599014 Inf 0.155628106803387 131.5 2071 False False 0 0 0 0 0 0 0 3.07033876389966 0.159799628612092 180.959738606129 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance No change no 1 +Streptomycin gid p.Glu40Gly gid_p.Glu40Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.50544998553101 0.0191837380556942 118.074698097101 1 973.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Streptomycin gid p.Glu40Lys gid_p.Glu40Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 4 0 8 0 10360 15608 0.000771604938271604 0.00033318123262376 0.00151980017311994 1 0.99976368249849 1 1 0.63058335244718 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 0.994255324648258 Inf 0.0253476044702962 80 2512 False False Inf 2.57069745416703 Inf 0.000385951370127364 0.000105168450723381 0.000987891267335943 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 3 0 7 0 7729 11874 0.000904860392967942 0.000363875741427306 0.00186346392020999 1 0.999689379610589 1 1 0.590383602774996 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.634666485213295 Inf 0.0613206110342261 89 2071 False False 0 0 0 0 0 0 0 Inf 2.21347144138593 Inf 0.000387997930677703 8.00216495883366e-05 0.0011334717876649 1 0.999689379610589 1 7 3) Uncertain significance No change no 1 +Streptomycin gid p.Glu40* gid_p.Glu40* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0386035211949905 Inf 0.399114533205004 308.5 2512 False False Inf 0.282736080598822 Inf 9.64599209028648e-05 2.44215077354346e-06 0.000537321795461189 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0393613144801391 Inf 0.394461726758121 237.5 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0.000129282482223658 3.27314370392442e-06 0.000720103058325324 1 0.999689379610589 1 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Glu57Gln gid_p.Glu57Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1642 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1354 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Glu57Lys gid_p.Glu57Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 6 10368 15602 0 0 0.000355731413006942 0.999615581752947 0.999163472525571 0.999858912630967 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1573 2512 False False 0 0 1.27838118563185 0 0 0.000355731413006942 0.999615581752947 0.999163472525571 0.999858912630967 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 7736 11869 0 0 0.000476732171726368 0.999578911908371 0.999017596768841 0.999863260157969 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1293 2071 False False 0 0 0 0 0 0 0 0 0 1.67480496260254 0 0 0.000476732171726368 0.999578911908371 0.999017596768841 0.999863260157969 15 3) Uncertain significance No change no 1 +Streptomycin gid p.Glu60fs gid_p.Glu60fs 1 frameshift (see "Genomic_coordinates" sheet) 1 39 18 21 20 22 10348 15586 0.00192901234567901 0.00117867659406302 0.00297763858885685 0.998590466427473 0.997866722379978 0.999116448603187 0.476190476190476 0.320040508860225 0.635822029078667 0.461538461538461 0.300947803007507 0.628189252793481 0.45 0.292588350039879 0.615093205465986 1.29101551714617 0.648064834981357 2.54620984980434 0.419318001599543 421 2512 False False 1.36925888182169 0.708521642385407 2.6311444197814 0.00173644607370248 0.00102944252093236 0.00274295033631364 0.998590466427473 0.997866722379978 0.999116448603187 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 16 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Glu60* gid_p.Glu60* 1 stop_gained (see "Genomic_coordinates" sheet) 1 2 2 0 3 1 10365 15607 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999935930292158 0.99964307871082 0.999998377896754 0.75 0.194120449683243 0.99369053679029 1 0.158113883008419 1 0.666666666666666 0.0942993240502461 0.991596241340387 Inf 0.282745237798141 Inf 0.159295442743639 172 2512 False False 4.51722141823444 0.362625225225282 236.854590713406 0.000192919841805729 2.33643418036207e-05 0.000696717215522511 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 2 1 1 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.53497091144149 0.0195519049186736 120.390152361053 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 2 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Glu92Ala gid_p.Glu92Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Glu92Asp gid_p.Glu92Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 3 5 5329 3487 5039 12121 0.513985339506172 0.504313754201885 0.523649065863616 0.776588928754484 0.769971017654378 0.783103603871071 0.604469147005444 0.59417247475796 0.614696731401455 0.375 0.0852334141372535 0.755136783633448 0.000859598853868194 0.00017730504270293 0.00251003772569097 1.44326255209366 0.224032675549653 7.42194768342956 0.700086220343845 NA NA False True 3.67610464587857 3.48169098529801 3.88122417815457 0.000595001983339944 0.000122720525610986 0.00173785404902744 0.776588928754484 0.769971017654378 0.783103603871071 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 8 3 5 4202 2620 3534 9254 0.543174767321613 0.531995314108636 0.554321671348563 0.779349839986525 0.771780942370732 0.78678155301546 0.615948402228085 0.60428611255099 0.627511501755569 0.375 0.0852334141372535 0.755136783633448 0.00114372855508959 0.000235926458465415 0.00333878736341646 1.57113752122241 0.243846703051805 8.08000244311792 0.692855469108701 NA NA False True 0 1 1 0 0 1 0 4.19969457008687 3.94378900473421 4.4719232532607 0.000848176420695504 0.000174948535766237 0.0024767112957132 0.779349839986525 0.771780942370732 0.78678155301546 7793 Not assoc w R Not assoc w R 5) Not assoc w R No change yes 1 +Streptomycin gid p.Glu92fs gid_p.Glu92fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Glu92Gln gid_p.Glu92Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 2 3 3 5 10365 15603 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999679651460789 0.999252573060182 0.999895975781355 0.375 0.0852334141372535 0.755136783633448 0.4 0.0527449505263169 0.853367200365326 0.285714285714285 0.0366925661760855 0.709579136262657 1.00356970574047 0.0837814067405228 8.76343411219021 1 610 2512 False False 0.903212735166425 0.140213309764784 4.64350502715881 0.000192919841805729 2.33643418036207e-05 0.000696717215522511 0.999679651460789 0.999252573060182 0.999895975781355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 2 2 3 4 7733 11870 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 0.999663129526697 0.999137704464366 0.999908206750254 0.428571428571428 0.0989882784425078 0.815948432359917 0.5 0.067585986488543 0.932414013511457 0.333333333333333 0.0432718682927417 0.777221904496487 1.53497995603258 0.111224606557735 21.1774865268504 0.649675481617945 486 2071 False False 0 0 0 0 0 0 0 1.15123496702444 0.168586646422245 6.80694398225105 0.000258564964447317 3.13149507641486e-05 0.00093371015947595 0.999663129526697 0.999137704464366 0.999908206750254 12 3) Uncertain significance No change no 1 +Streptomycin gid p.Glu92Gly gid_p.Glu92Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 4 0 6 1 10362 15607 0.000578703703703703 0.000212402724453782 0.00125916554902567 0.999935930292158 0.99964307871082 0.999998377896754 0.857142857142857 0.421276802956804 0.996389703138099 1 0.397635364383525 1 0.8 0.28358206388191 0.994949236620532 Inf 0.993997628876839 Inf 0.0253632721542094 83 2512 False False 9.03705848291835 1.09610816025756 414.873240547969 0.000385876905267219 0.000105148157815303 0.000987700722510407 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 2 3) Uncertain significance No change no 1 +Streptomycin gid p.Glu92Lys gid_p.Glu92Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 5 0 10363 15608 0.000482253086419753 0.000156604214122162 0.00112505595550109 1 0.99976368249849 1 1 0.478176249895018 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.282817919326354 Inf 0.15924624517817 167 2512 False False Inf 1.37979907306709 Inf 0.00019295706705258 2.33688502833084e-05 0.000696851618150259 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 4 0 7732 11874 0.000517063081695967 0.000140899683864147 0.00132335286075948 1 0.999689379610589 1 1 0.397635364383525 1 1 0.025 1 1 0.025 1 Inf 0.0393714946924981 Inf 0.394399959198245 222.5 2071 False False 0 0 0 0 0 0 0 Inf 1.01342344657205 Inf 0.000129315918789603 3.27399024170944e-06 0.000720289244853199 1 0.999689379610589 1 11 3) Uncertain significance No change no 1 +Streptomycin gid p.Glu92* gid_p.Glu92* 1 stop_gained (see "Genomic_coordinates" sheet) 1 5 3 2 4 2 10364 15606 0.000385802469135802 0.000105127872737001 0.000987510251175401 0.999871860584315 0.999537193839207 0.999984481345552 0.666666666666666 0.222778095503512 0.956728131707258 0.6 0.146632799634673 0.947255049473683 0.6 0.146632799634673 0.947255049473683 2.25868390582786 0.258682921900149 27.0502914685091 0.394213087252362 286 2512 False False 3.01157854110382 0.43150328206235 33.3041852472562 0.000289379762708594 5.96810402691469e-05 0.000845455262078775 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1283 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 5 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Glu92Val gid_p.Glu92Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1662 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1372 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Glu99Gly gid_p.Glu99Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 5 10366 15603 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999679651460789 0.999252573060182 0.999895975781355 0.285714285714285 0.0366925661760855 0.709579136262657 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1593 2512 False False 0.602083735288443 0.0572994001432256 3.67859568857157 0 0 0.000355800035063835 0.999679651460789 0.999252573060182 0.999895975781355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 5 7735 11869 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999578911908371 0.999017596768841 0.999863260157969 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1313 2071 False False 0 0 0 0 0 0 0 0.306890756302521 0.00649200912492085 2.74344385104518 0 0 0.000476793790149404 0.999578911908371 0.999017596768841 0.999863260157969 5 3) Uncertain significance No change no 1 +Streptomycin gid p.Glu99Lys gid_p.Glu99Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1577 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1297 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance No change no 1 +Streptomycin gid p.Glu99* gid_p.Glu99* 1 stop_gained (see "Genomic_coordinates" sheet) 1 25 22 3 23 4 10345 15604 0.00221836419753086 0.00140675621922997 0.00332678737658432 0.999743721168631 0.999343955596995 0.999930168370675 0.851851851851851 0.662689135975755 0.958112603526232 0.88 0.687809692713764 0.974534603352266 0.846153846153846 0.651321214464638 0.956436523461076 11.0613178669244 3.32166855323523 57.738186723683 9.03246975875529e-07 25 2512 True False 8.6730787820203 2.962095188442 34.5111152598492 0.00212211825986302 0.00133038321705373 0.0032111599966697 0.999743721168631 0.999343955596995 0.999930168370675 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 25 22 3 23 4 7713 11870 0.0029731127197518 0.0018856032714534 0.00445780906880445 0.999663129526697 0.999137704464366 0.999908206750254 0.851851851851851 0.662689135975755 0.958112603526232 0.88 0.687809692713764 0.974534603352266 0.846153846153846 0.651321214464638 0.956436523461076 11.2857081118458 3.38853897067511 58.9175021297309 7.10344098673911e-07 15 2071 True False 0 0 0 0 0 0 0 8.84902113315182 3.021423377938 35.2358345773418 0.00284421460892049 0.00178328607826669 0.00430302679573011 0.999663129526697 0.999137704464366 0.999908206750254 1 Assoc w RI 1) Assoc w R UP from AwRI to AwR yes 4 +Streptomycin gid p.Gly109Ala gid_p.Gly109Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 1 3 10367 15605 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999807790876473 0.99943838714673 0.999960360103688 0.25 0.00630946320970987 0.805879550316756 0.333333333333333 0.00840375865961264 0.905700675949754 0.25 0.00630946320970987 0.805879550316756 0.752628532844603 0.0127612189150725 14.4596792780633 1 973.5 2512 False False 0.501752355229735 0.00956153582768186 6.25014259670444 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0393529118200762 Inf 0.394512723749298 338.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 6 3) Uncertain significance No change no 1 +Streptomycin gid p.Gly109Asp gid_p.Gly109Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Gly109fs gid_p.Gly109fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Gly109Val gid_p.Gly109Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1636 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1347 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Gly117Arg gid_p.Gly117Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 13 4 9 8 11 10360 15597 0.000771604938271604 0.00033318123262376 0.00151980017311994 0.999295233213736 0.998739328260189 0.999648132128855 0.421052631578947 0.202521438977162 0.665002155988264 0.307692307692307 0.0909203945720966 0.614261661750705 0.266666666666666 0.0778715462910436 0.551003241036971 0.669111969111969 0.150530515435595 2.39815556975095 0.582234814930619 575 2512 False False 1.09491049491049 0.382183879836686 2.98972267481287 0.000385951370127364 0.000105168450723381 0.000987891267335943 0.999295233213736 0.998739328260189 0.999648132128855 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 1 6 5 7 7731 11867 0.000646328852119958 0.0002098934625097 0.00150766595359595 0.999410476671719 0.998785736251934 0.999762949244471 0.416666666666666 0.15165222980843 0.723330314317894 0.142857142857142 0.00361029686190058 0.578723197043195 0.125 0.0031597235312519 0.526509670875206 0.255831500883887 0.00556537955034236 2.10950214027224 0.256922482010135 171 2071 False False 0 0 0 0 0 0 0 1.0964207180738 0.274287483368725 4.01478723207519 0.000129332643559234 3.27441367482914e-06 0.000720382374226452 0.999410476671719 0.998785736251934 0.999762949244471 12 3) Uncertain significance No change no 1 +Streptomycin gid p.Gly117fs gid_p.Gly117fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1616 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1332 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Gly117Glu gid_p.Gly117Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 3 0 3 0 10365 15608 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 1 0.99976368249849 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.622129167636411 Inf 0.06357591560857 116 2512 False False Inf 0.622129167636411 Inf 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 3) Uncertain significance No change no 1 +Streptomycin gid p.Gly117Trp gid_p.Gly117Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.282736080598822 Inf 0.159301643065502 181.5 2512 False False Inf 0.282736080598822 Inf 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Gly117Val gid_p.Gly117Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 3 1 3 1 10365 15607 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999935930292158 0.99964307871082 0.999998377896754 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 4.51722141823444 0.362625225225282 236.854590713406 0.308516935797272 279.5 2512 False False 4.51722141823444 0.362625225225282 236.854590713406 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 2 1 2 1 7734 11873 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999915782381674 0.999530859783396 0.999997867796783 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 3.07033876389966 0.159799628612092 180.959738606129 0.566060794245423 475.5 2071 False False 0 0 0 0 0 0 0 3.07033876389966 0.159799628612092 180.959738606129 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance No change no 1 +Streptomycin gid p.Gly129fs gid_p.Gly129fs 1 frameshift (see "Genomic_coordinates" sheet) 1 14 6 8 22 13 10346 15595 0.00212191358024691 0.00133025485608362 0.00321085044734721 0.999167093798052 0.998576126182689 0.999556440358575 0.628571428571428 0.449231164187322 0.78526788188561 0.428571428571428 0.176611089982117 0.711390599961692 0.31578947368421 0.125760635872983 0.56550156884615 1.13050937560409 0.323197098454397 3.71629368510857 0.792764078743882 598 2512 False False 2.55089295008104 1.2287742266227 5.51482836896479 0.000579598145285935 0.000212731057437013 0.00126111104538689 0.999167093798052 0.998576126182689 0.999556440358575 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 4 7 17 11 7719 11863 0.00219751809720785 0.00128064014327926 0.00351611538908953 0.999073606198416 0.998343031567643 0.999537459717592 0.607142857142857 0.405768206487563 0.784957170839039 0.363636363636363 0.109263443819098 0.692095284988322 0.266666666666666 0.0778715462910436 0.551003241036971 0.878204060481557 0.188464361361347 3.45588054642369 1 512 2071 False False 0 0 0 0 0 0 0 2.37514279993875 1.04873176595142 5.61285272676845 0.000517933445552246 0.000141136887344165 0.00132557953882592 0.999073606198416 0.998343031567643 0.999537459717592 36 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Gly130Arg gid_p.Gly130Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1646 2512 False False Inf 0.282736080598822 Inf 0 0 0.000355800035063835 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1359 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0 0 0.000476855424503066 1 0.999689379610589 1 3 3) Uncertain significance No change no 1 +Streptomycin gid p.Gly130Ser gid_p.Gly130Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Gly13Ala gid_p.Gly13Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 58.6634076928655 1 973.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 59.8138891519084 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Gly13Arg gid_p.Gly13Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 2 10366 15606 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999871860584315 0.999537193839207 0.999984481345552 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 58.6653062545381 1 973.5 2512 False False 1.50549874590005 0.10909391082996 20.7696540777406 0 0 0.000355800035063835 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 2 7734 11872 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999831564763348 0.99939168785815 0.999979601060482 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 59.8165824855725 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53504008275148 0.111228967362952 21.1783159842378 0 0 0.000476855424503066 0.999831564763348 0.99939168785815 0.999979601060482 2 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Gly13Glu gid_p.Gly13Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Gly13* gid_p.Gly13* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Gly13Val gid_p.Gly13Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Gly157Arg gid_p.Gly157Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 2 6 2 6 10366 15602 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999615581752947 0.999163472525571 0.999858912630967 0.25 0.0318540262499442 0.650855794412824 0.25 0.0318540262499442 0.650855794412824 0.25 0.0318540262499442 0.650855794412824 0.50170428966493 0.0495150381555913 2.80649490654312 0.489469891611724 424 2512 False False 0.50170428966493 0.0495150381555913 2.80649490654312 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999615581752947 0.999163472525571 0.999858912630967 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 2 5 2 5 7734 11869 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999578911908371 0.999017596768841 0.999863260157969 0.285714285714285 0.0366925661760855 0.709579136262657 0.285714285714285 0.0366925661760855 0.709579136262657 0.285714285714285 0.0366925661760855 0.709579136262657 0.61386087406258 0.0584192274045222 3.75047184857656 0.711105236128344 499 2071 False False 0 0 0 0 0 0 0 0.61386087406258 0.0584192274045222 3.75047184857656 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999578911908371 0.999017596768841 0.999863260157969 7 3) Uncertain significance No change no 1 +Streptomycin gid p.Gly157Glu gid_p.Gly157Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1663 2512 False False Inf 0.282736080598822 Inf 0 0 0.000355800035063835 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1373 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0 0 0.000476855424503066 1 0.999689379610589 1 14 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Gly164Arg gid_p.Gly164Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Streptomycin gid p.Gly164Asp gid_p.Gly164Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 2 1 5 1 10363 15607 0.000482253086419753 0.000156604214122162 0.00112505595550109 0.999935930292158 0.99964307871082 0.999998377896754 0.833333333333333 0.358765421002325 0.99578925548551 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 3.01206214416674 0.156774796644794 177.525647021232 0.567644422408404 566 2512 False False 7.53015536041686 0.842353453161053 355.554202953959 0.00019295706705258 2.33688502833084e-05 0.000696851618150259 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 2 1 5 1 7731 11873 0.000646328852119958 0.0002098934625097 0.00150766595359595 0.999915782381674 0.999530859783396 0.999997867796783 0.833333333333333 0.358765421002325 0.99578925548551 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 3.07153020307851 0.159861632605525 181.029874007598 0.566029924660661 471.5 2071 False False 0 0 0 0 0 0 0 7.67882550769628 0.858951237970164 362.566724149337 0.000258631837579206 3.13230502042936e-05 0.00093395156507162 0.999915782381674 0.999530859783396 0.999997867796783 3 3) Uncertain significance No change no 1 +Streptomycin gid p.Gly164Cys gid_p.Gly164Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 3 10367 15605 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999807790876473 0.99943838714673 0.999960360103688 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.01590723734217 0.520331087227479 541.5 2512 False False 0.501752355229735 0.00956153582768186 6.25014259670444 0 0 0.000355765720726338 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1339 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 4 3) Uncertain significance No change no 1 +Streptomycin gid p.Gly164fs gid_p.Gly164fs 1 frameshift (see "Genomic_coordinates" sheet) 1 5 3 2 17 10 10351 15598 0.00163966049382716 0.0009554436768022 0.00262396149717064 0.999359302921578 0.998822051949738 0.999692719453314 0.629629629629629 0.423679572504296 0.805992841284865 0.6 0.146632799634673 0.947255049473683 0.23076923076923 0.0503810734911515 0.53813153923404 2.26036131774707 0.258874975922256 27.0703459567907 0.394022088982186 282 2512 False False 2.56174282678002 1.10723869716311 6.26271317211697 0.000289743094456248 5.97559780019454e-05 0.00084651648066852 0.999359302921578 0.998822051949738 0.999692719453314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 3 1 17 8 7719 11866 0.00219751809720785 0.00128064014327926 0.00351611538908953 0.999326259053394 0.998672895689377 0.999709083033384 0.68 0.464999282502627 0.85050457738643 0.75 0.194120449683243 0.99369053679029 0.272727272727272 0.0602177341729066 0.609742559572421 4.61173727166731 0.370186765903203 241.807782356183 0.307217255337905 210 2071 False False 0 0 0 0 0 0 0 3.26664723409768 1.33523675260458 8.7494524821709 0.000388500388500388 8.01252869988489e-05 0.00113493908693179 0.999326259053394 0.998672895689377 0.999709083033384 9 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Gly164Ser gid_p.Gly164Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Gly164Val gid_p.Gly164Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.752676762805054 0.0127620362920002 14.460605698152 1 1332 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance No change no 1 +Streptomycin gid p.Gly17fs gid_p.Gly17fs 1 frameshift (see "Genomic_coordinates" sheet) 1 3 1 2 1 7 10367 15601 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999551512045105 0.999076163117038 0.999819666176692 0.125 0.0031597235312519 0.526509670875206 0.333333333333333 0.00840375865961264 0.905700675949754 0.125 0.0031597235312519 0.526509670875206 0.752435613002797 0.0127579494073961 14.4559735976047 1 973.5 2512 False False 0.214981603715084 0.00477381113707295 1.6738454938462 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999551512045105 0.999076163117038 0.999819666176692 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 1 7 7735 11867 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999410476671719 0.998785736251934 0.999762949244471 0.125 0.0031597235312519 0.526509670875206 0.333333333333333 0.00840375865961264 0.905700675949754 0.125 0.0031597235312519 0.526509670875206 0.767097608274078 0.0130060132425677 14.7382457944791 1 512 2071 False False 0 0 0 0 0 0 0 0.219170745221165 0.0048665806440923 1.70661149583256 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999410476671719 0.998785736251934 0.999762949244471 25 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Gly182Cys gid_p.Gly182Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1598 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1315 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Gly182fs gid_p.Gly182fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Gly182Val gid_p.Gly182Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Gly192Arg gid_p.Gly192Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 2 3) Uncertain significance No change no 1 +Streptomycin gid p.Gly192fs gid_p.Gly192fs 1 frameshift (see "Genomic_coordinates" sheet) 1 5 3 2 11 4 10357 15604 0.00106095679012345 0.000529741017552837 0.00189754996565939 0.999743721168631 0.999343955596995 0.999930168370675 0.733333333333333 0.448996758963029 0.922128453708956 0.6 0.146632799634673 0.947255049473683 0.428571428571428 0.0989882784425078 0.815948432359917 2.25992082649415 0.258824555811357 27.0650787333583 0.394072204722169 283 2512 False False 4.14318818190595 1.22719918637044 17.8375204370869 0.000289575289575289 5.97213679851248e-05 0.000846026356624043 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 2 2 10 4 7726 11870 0.00129265770423991 0.000620048157733657 0.00237595446225449 0.999663129526697 0.999137704464366 0.999908206750254 0.714285714285714 0.418964742816338 0.916110681692872 0.5 0.067585986488543 0.932414013511457 0.333333333333333 0.0432718682927417 0.777221904496487 1.53637069634998 0.111325379779949 21.196686001171 0.649492200453379 480 2071 False False 0 0 0 0 0 0 0 3.84092674087496 1.10725979503529 16.7765671286618 0.00025879917184265 3.1343317146679e-05 0.000934555625537193 0.999663129526697 0.999137704464366 0.999908206750254 7 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Gly192Val gid_p.Gly192Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1574 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1294 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 5 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Gly208Glu gid_p.Gly208Glu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1582 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1303 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 1 3) Uncertain significance No change no 1 +Streptomycin gid p.Gly214Arg gid_p.Gly214Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance No change no 1 +Streptomycin gid p.Gly221Arg gid_p.Gly221Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1656 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Gly222Arg gid_p.Gly222Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1637 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1348 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Gly28Arg gid_p.Gly28Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1559 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 3) Uncertain significance No change no 1 +Streptomycin gid p.Gly28Glu gid_p.Gly28Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 3 10367 15605 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999807790876473 0.99943838714673 0.999960360103688 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.01590723734217 0.520331087227479 541.5 2512 False False 0.501752355229735 0.00956153582768186 6.25014259670444 0 0 0.000355765720726338 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Gly28* gid_p.Gly28* 1 stop_gained (see "Genomic_coordinates" sheet) 1 5 3 2 3 2 10365 15606 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999871860584315 0.999537193839207 0.999984481345552 0.6 0.146632799634673 0.947255049473683 0.6 0.146632799634673 0.947255049473683 0.6 0.146632799634673 0.947255049473683 2.25846599131693 0.258657968313028 27.0476864113414 0.394237929959746 288 2512 False False 2.25846599131693 0.258657968313028 27.0476864113414 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 3 1 3 1 7733 11873 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 0.999915782381674 0.999530859783396 0.999997867796783 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 4.60610371136686 0.369734697559289 241.512824517625 0.307287813162931 214 2071 False False 0 0 0 0 0 0 0 4.60610371136686 0.369734697559289 241.512824517625 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 0.999915782381674 0.999530859783396 0.999997867796783 1 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Gly28Val gid_p.Gly28Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 58.6634076928655 1 973.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Gly30_Pro38del gid_p.Gly30_Pro38del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Streptomycin gid p.Gly30Arg gid_p.Gly30Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1664 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1374 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Gly30Asp gid_p.Gly30Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 2 2 7 3 10361 15605 0.000675154320987654 0.000271488767107418 0.00139057803317028 0.999807790876473 0.99943838714673 0.999960360103688 0.7 0.347547149940002 0.933260488822265 0.5 0.067585986488543 0.932414013511457 0.4 0.0527449505263169 0.853367200365326 1.50612875205096 0.109139563862978 20.7783511384376 0.653556163741046 579 2512 False False 3.51430042145224 0.802019002880655 21.0638674909524 0.000192994306667953 2.33733605032816e-05 0.000696986072642812 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 2 1 6 2 7730 11872 0.00077559462254395 0.000284681048736677 0.00168737281383633 0.999831564763348 0.99939168785815 0.999979601060482 0.75 0.349144205587175 0.968145973750055 0.666666666666666 0.0942993240502461 0.991596241340387 0.5 0.067585986488543 0.932414013511457 3.07166882276843 0.15986884363965 181.038035257977 0.566026335421252 470 2071 False False 0 0 0 0 0 0 0 4.60750323415265 0.82353764401184 46.6843305297194 0.000258665287118468 3.13271014957261e-05 0.000934072314686065 0.999831564763348 0.99939168785815 0.999979601060482 17 3) Uncertain significance No change no 1 +Streptomycin gid p.Gly30Cys gid_p.Gly30Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 4 10368 15604 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.64276114479861 0.280482632628927 227 2512 False False 0 0 2.28044779470556 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 7736 11870 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.71406862449918 0.283346149162266 180.5 2071 False False 0 0 0 0 0 0 0 0 0 2.32513012450998 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Gly30fs gid_p.Gly30fs 1 frameshift (see "Genomic_coordinates" sheet) 1 15 7 8 12 8 10356 15600 0.0011574074074074 0.000598187780713703 0.00202088408121616 0.999487442337262 0.998990308225149 0.99977868883794 0.6 0.360542587307489 0.808809939274692 0.466666666666666 0.212666729519307 0.734138652722603 0.466666666666666 0.212666729519307 0.734138652722603 1.3180764774044 0.406762114005814 4.1610303041303 0.606620629007323 577 2512 False False 2.2595596755504 0.848967095162942 6.37501616889857 0.000675480073337836 0.000271619776714842 0.00139124872694956 0.999487442337262 0.998990308225149 0.99977868883794 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 5 4 10 4 7726 11870 0.00129265770423991 0.000620048157733657 0.00237595446225449 0.999663129526697 0.999137704464366 0.999908206750254 0.714285714285714 0.418964742816338 0.916110681692872 0.555555555555555 0.212008506778868 0.863004337734833 0.555555555555555 0.212008506778868 0.863004337734833 1.92046337043748 0.413189740391972 9.68149118924412 0.329984182046608 216 2071 False False 0 0 0 0 0 0 0 3.84092674087496 1.10725979503529 16.7765671286618 0.000646746863277713 0.000210029231320679 0.0015086406112362 0.999663129526697 0.999137704464366 0.999908206750254 35 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Gly30Ser gid_p.Gly30Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 3 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Gly30Val gid_p.Gly30Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1684 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Streptomycin gid p.Gly34Ala gid_p.Gly34Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 58.6634076928655 1 973.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1288 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 4 3) Uncertain significance No change no 1 +Streptomycin gid p.Gly34Arg gid_p.Gly34Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 2 3 3 4 10365 15604 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999743721168631 0.999343955596995 0.999930168370675 0.428571428571428 0.0989882784425078 0.815948432359917 0.4 0.0527449505263169 0.853367200365326 0.333333333333333 0.0432718682927417 0.777221904496487 1.00363402476282 0.083786777820258 8.76399595691691 1 973.5 2512 False False 1.12908827785817 0.165354282141397 6.67552078522212 0.000192919841805729 2.33643418036207e-05 0.000696717215522511 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 1 3 2 4 7734 11870 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999663129526697 0.999137704464366 0.999908206750254 0.333333333333333 0.0432718682927417 0.777221904496487 0.25 0.00630946320970987 0.805879550316756 0.2 0.00505076337946806 0.716417936118089 0.511593828118265 0.00974865580710569 6.37310858445497 1 806.5 2071 False False 0 0 0 0 0 0 0 0.767390742177398 0.0693820092373707 5.35625075908251 0.000129282482223658 3.27314370392442e-06 0.000720103058325324 0.999663129526697 0.999137704464366 0.999908206750254 2 3) Uncertain significance No change no 1 +Streptomycin gid p.Gly34Glu gid_p.Gly34Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 4 2 4 3 10364 15605 0.000385802469135802 0.000105127872737001 0.000987510251175401 0.999807790876473 0.99943838714673 0.999960360103688 0.571428571428571 0.184051567640083 0.901011721557492 0.666666666666666 0.222778095503512 0.956728131707258 0.571428571428571 0.184051567640083 0.901011721557492 3.01138556541875 0.431475630703707 33.3020602397528 0.225039094001434 215 2512 False False 2.00759037694583 0.339557946095546 13.7090540440321 0.000385802469135802 0.000105127872737001 0.000987510251175401 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 3 2 3 3 7733 11871 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 0.999747347145022 0.999261820436506 0.999947893876346 0.5 0.118117248757025 0.881882751242974 0.6 0.146632799634673 0.947255049473683 0.5 0.118117248757025 0.881882751242974 2.30266390792706 0.26370204466552 27.577228896778 0.389337997088707 219 2071 False False 0 0 0 0 0 0 0 1.53510927195137 0.205550714955708 11.4678941037862 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 0.999747347145022 0.999261820436506 0.999947893876346 10 3) Uncertain significance No change no 1 +Streptomycin gid p.Gly34Trp gid_p.Gly34Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 10 7 3 9 3 10359 15605 0.000868055555555555 0.000397004661559041 0.00164719739830421 0.999807790876473 0.99943838714673 0.999960360103688 0.75 0.42814153812181 0.945139355472007 0.7 0.347547149940002 0.933260488822265 0.7 0.347547149940002 0.933260488822265 3.51497892331949 0.802173811172317 21.0679349530846 0.1009345924617 132 2512 False False 4.51925861569649 1.12742337387643 25.9566145270552 0.000675284584217634 0.000271541155781981 0.00139084623306823 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 5 1 7 1 7729 11873 0.000904860392967942 0.000363875741427306 0.00186346392020999 0.999915782381674 0.999530859783396 0.999997867796783 0.875 0.473490329124793 0.996840276468748 0.833333333333333 0.358765421002325 0.99578925548551 0.833333333333333 0.358765421002325 0.99578925548551 7.68081252425928 0.859173279519308 362.660352005347 0.0384299926007015 76 2071 False False 0 0 0 0 0 0 0 10.7531375339629 1.38092189761868 483.549887206656 0.000646495991724851 0.000209947748965095 0.00150805566549033 0.999915782381674 0.999530859783396 0.999997867796783 16 3) Uncertain significance No change no 1 +Streptomycin gid p.Gly34Val gid_p.Gly34Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 12 7 5 9 5 10359 15603 0.000868055555555555 0.000397004661559041 0.00164719739830421 0.999679651460789 0.999252573060182 0.999895975781355 0.642857142857142 0.351380110615991 0.87240157014084 0.583333333333333 0.276669685682105 0.848347770191569 0.583333333333333 0.276669685682105 0.848347770191569 2.10871705763104 0.575932990846046 8.42782818605043 0.240923594491906 216 2512 False False 2.71120764552562 0.815672905647804 10.2988838251607 0.000675284584217634 0.000271541155781981 0.00139084623306823 0.999679651460789 0.999252573060182 0.999895975781355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 7 3 9 3 7727 11871 0.00116339193381592 0.000532110502771461 0.00220732634615895 0.999747347145022 0.999261820436506 0.999947893876346 0.75 0.42814153812181 0.945139355472007 0.7 0.347547149940002 0.933260488822265 0.7 0.347547149940002 0.933260488822265 3.58470298951727 0.817996757842696 21.487120845776 0.0573151852365764 87 2071 False False 0 0 0 0 0 0 0 4.60890384366507 1.14964794320629 26.4730983956512 0.000905094388414791 0.000363969858500493 0.00186394557768835 0.999747347145022 0.999261820436506 0.999947893876346 7 3) Uncertain significance No change no 1 +Streptomycin gid p.Gly37Ala gid_p.Gly37Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 11 4 7 14 11 10354 15597 0.0013503086419753 0.00073841672613154 0.00226455162408295 0.999295233213736 0.998739328260189 0.999648132128855 0.56 0.349281633991335 0.755976334852791 0.363636363636363 0.109263443819098 0.692095284988322 0.266666666666666 0.0778715462910436 0.551003241036971 0.860785341758878 0.184743692535829 3.38698889336362 1 973.5 2512 False False 1.91720371573568 0.808189744850174 4.66868224799756 0.000386174937246572 0.000105229376471625 0.000988463343181313 0.999295233213736 0.998739328260189 0.999648132128855 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 3 7 13 11 7723 11863 0.00168045501551189 0.000895065386794453 0.00287191489837179 0.999073606198416 0.998343031567643 0.999537459717592 0.541666666666666 0.328208075695178 0.744469798005253 0.3 0.0667395111777345 0.652452850059997 0.214285714285714 0.0465792878898673 0.507975677048471 0.65831190691996 0.109844744591892 2.88478556187433 0.749285551069961 502 2071 False False 0 0 0 0 0 0 0 1.81534495544595 0.749979550703812 4.47763106657287 0.000388299249288118 8.00837998379023e-05 0.00113435171159424 0.999073606198416 0.998343031567643 0.999537459717592 5 3) Uncertain significance No change no 1 +Streptomycin gid p.Gly37Arg gid_p.Gly37Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 11 9 2 34 15 10334 15593 0.00327932098765432 0.00227206172473011 0.00457953537856319 0.999038954382368 0.998415396005541 0.999462013453075 0.693877551020408 0.545847563494754 0.817480552354126 0.818181818181818 0.482244147639827 0.97716880170004 0.375 0.187992928196002 0.594063615992055 6.79006193148829 1.40493212764445 64.6521286351953 0.00947830453760098 66 2512 False False 3.42017934326817 1.81237430444715 6.76174380717387 0.000870153727158464 0.000397964439315888 0.00165117727223806 0.999038954382368 0.998415396005541 0.999462013453075 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 7 2 27 7 7709 11867 0.00349017580144777 0.00230126940484272 0.00507398979278873 0.999410476671719 0.998785736251934 0.999762949244471 0.794117647058823 0.621022251460316 0.912978694541873 0.777777777777777 0.399906426283687 0.971855026522101 0.5 0.230360541448062 0.769639458551937 5.38779348813075 1.02541141045894 53.1377584549638 0.0338609383288341 73 2071 False False 0 0 0 0 0 0 0 5.93756833385838 2.52071921074269 16.1550319631556 0.000907205806117159 0.000364819108189858 0.00186829172576332 0.999410476671719 0.998785736251934 0.999762949244471 18 3) Uncertain significance No change no 1 +Streptomycin gid p.Gly37fs gid_p.Gly37fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Gly37Glu gid_p.Gly37Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 2 1 4 1 10364 15607 0.000385802469135802 0.000105127872737001 0.000987510251175401 0.999935930292158 0.99964307871082 0.999998377896754 0.8 0.28358206388191 0.994949236620532 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 3.01177151678888 0.156759670501328 177.508538398662 0.567652651313325 567 2512 False False 6.02354303357776 0.595936886271208 296.214625622934 0.000192938452633609 2.33665958259919e-05 0.00069678441035516 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 4 0 7732 11874 0.000517063081695967 0.000140899683864147 0.00132335286075948 1 0.999689379610589 1 1 0.397635364383525 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.288354310256752 Inf 0.155563508998328 117.5 2071 False False 0 0 0 0 0 0 0 Inf 1.01342344657205 Inf 0.00025859839668994 3.13189999605699e-05 0.000933830846672283 1 0.999689379610589 1 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Gly37* gid_p.Gly37* 1 stop_gained (see "Genomic_coordinates" sheet) 1 3 2 1 2 1 10366 15607 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999935930292158 0.99964307871082 0.999998377896754 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 3.01119043025274 0.156729426968348 177.474331043773 0.567669114955046 570 2512 False False 3.01119043025274 0.156729426968348 177.474331043773 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 NA Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Gly37Val gid_p.Gly37Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 15 1 10353 15607 0.00144675925925925 0.00080995915704588 0.00238508849276012 0.999935930292158 0.99964307871082 0.999998377896754 0.9375 0.697679261565468 0.998418888277234 NA NA NA 0 0 0.975 NA NA NA NA 1594 2512 False False 22.6122862938278 3.47757169663562 947.769322870089 0 0 0.000356246724570853 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 10 9 1 15 1 7721 11873 0.00193898655635987 0.00108562946918638 0.00319605008438842 0.999915782381674 0.999530859783396 0.999997867796783 0.9375 0.697679261565468 0.998418888277234 0.9 0.554983882971804 0.997471421455538 0.9 0.554983882971804 0.997471421455538 13.8397875922807 1.91690667475992 604.928684507515 0.00148285556577917 40 2071 False False 0 0 0 0 0 0 0 23.0663126538013 3.54672145861623 966.72074138712 0.00116429495472186 0.00053252362900554 0.00220903876914212 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Gly42Val gid_p.Gly42Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Gly62Ser gid_p.Gly62Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Gly62Val gid_p.Gly62Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Gly69Arg gid_p.Gly69Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0386035211949905 Inf 0.399114533205004 308.5 2512 False False Inf 0.282736080598822 Inf 9.64599209028648e-05 2.44215077354346e-06 0.000537321795461189 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 3) Uncertain significance No change no 1 +Streptomycin gid p.Gly69Asp gid_p.Gly69Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 14 10 4 13 4 10355 15604 0.00125385802469135 0.000667790166179422 0.00214318097672708 0.999743721168631 0.999343955596995 0.999930168370675 0.764705882352941 0.501006726795419 0.931892259562643 0.714285714285714 0.418964742816338 0.916110681692872 0.714285714285714 0.418964742816338 0.916110681692872 3.76726219217769 1.08616202324613 16.4537940330896 0.025403930694589 90 2512 False False 4.897440849831 1.51234677395735 20.6157459869453 0.000964785335262904 0.000462745943899107 0.0017735564881541 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 12 8 4 10 4 7726 11870 0.00129265770423991 0.000620048157733657 0.00237595446225449 0.999663129526697 0.999137704464366 0.999908206750254 0.714285714285714 0.418964742816338 0.916110681692872 0.666666666666666 0.348875506418814 0.900753908850416 0.666666666666666 0.348875506418814 0.900753908850416 3.07274139269997 0.822810269363308 13.9454177951702 0.0741244958645984 98 2071 False False 0 0 0 0 0 0 0 3.84092674087496 1.10725979503529 16.7765671286618 0.00103439358675976 0.000446680156528578 0.00203714489989349 0.999663129526697 0.999137704464366 0.999908206750254 69 Assoc w R 3) Uncertain significance DOWN from AwR to Uncertain yes 2 +Streptomycin gid p.Gly69fs gid_p.Gly69fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Gly69Ile gid_p.Gly69Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1562 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Streptomycin gid p.Gly69Ser gid_p.Gly69Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 58.6540000158548 1 973.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 59.801132462225 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 5 3) Uncertain significance No change no 1 +Streptomycin gid p.Gly71Ala gid_p.Gly71Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.50544998553101 0.0191837380556942 118.074698097101 1 973.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.53497091144149 0.0195519049186736 120.390152361053 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Gly71Arg gid_p.Gly71Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 3 0 5 0 10363 15608 0.000482253086419753 0.000156604214122162 0.00112505595550109 1 0.99976368249849 1 1 0.478176249895018 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.622249211987883 Inf 0.0635538067882081 110.5 2512 False False Inf 1.37979907306709 Inf 0.000289407678950414 5.96867980365928e-05 0.000845536799804338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 4 0 7732 11874 0.000517063081695967 0.000140899683864147 0.00132335286075948 1 0.999689379610589 1 1 0.397635364383525 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.288354310256752 Inf 0.155563508998328 117.5 2071 False False 0 0 0 0 0 0 0 Inf 1.01342344657205 Inf 0.00025859839668994 3.13189999605699e-05 0.000933830846672283 1 0.999689379610589 1 3 3) Uncertain significance No change no 1 +Streptomycin gid p.Gly71fs gid_p.Gly71fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1617 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Gly71Glu gid_p.Gly71Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 1 0.025 1 0.333333333333333 0.00840375865961264 0.905700675949754 Inf 0.0385948515967487 Inf 0.399168399168399 414 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1375 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 6 3) Uncertain significance No change no 1 +Streptomycin gid p.Gly71* gid_p.Gly71* 1 stop_gained (see "Genomic_coordinates" sheet) 1 3 1 2 6 5 10362 15603 0.000578703703703703 0.000212402724453782 0.00125916554902567 0.999679651460789 0.999252573060182 0.999895975781355 0.545454545454545 0.233793597659345 0.832511905936292 0.333333333333333 0.00840375865961264 0.905700675949754 0.166666666666666 0.00421074451448947 0.641234578997674 0.752895193977996 0.0127657375678226 14.464802311408 1 973.5 2512 False False 1.80694846554719 0.459318678907041 7.48649420578721 9.64971533339766e-05 2.44309341478262e-06 0.000537529149810079 0.999679651460789 0.999252573060182 0.999895975781355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 2 3 7734 11871 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999747347145022 0.999261820436506 0.999947893876346 0.4 0.0527449505263169 0.853367200365326 0.5 0.012579117093425 0.987420882906574 0.25 0.00630946320970987 0.805879550316756 1.53491078355314 0.0195511386955543 120.385442796903 1 806.5 2071 False False 0 0 0 0 0 0 0 1.02327385570209 0.0854221600622099 8.93608975066686 0.000129282482223658 3.27314370392442e-06 0.000720103058325324 0.999747347145022 0.999261820436506 0.999947893876346 6 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Gly73Ala gid_p.Gly73Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 37 26 11 33 14 10335 15594 0.00318287037037037 0.00219192358584956 0.00446705589312306 0.99910302409021 0.99849548434986 0.999509530910458 0.702127659574468 0.551064312793674 0.826611497292222 0.702702702702702 0.530200465005933 0.841274563620371 0.65 0.483155546351009 0.793717509129233 3.56638078902229 1.70187765826252 8.00028788374925 0.000278953969549115 39 2512 True False 3.5565830396019 1.85090960944829 7.19665283914798 0.00250941028858218 0.00163986480001902 0.00367472076122035 0.99910302409021 0.99849548434986 0.999509530910458 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance 1 1 1 0 5 3 7731 11871 0.000646328852119958 0.0002098934625097 0.00150766595359595 0.999747347145022 0.999261820436506 0.999947893876346 0.625 0.244863216366551 0.914766585862746 1 0.025 1 0.25 0.00630946320970987 0.805879550316756 Inf 0.039366638046149 Inf 0.394429424067744 224 2071 False False 0 0 0 0 0 0 0 2.55917733798991 0.497713634211278 16.4842738218502 0.000129332643559234 3.27441367482914e-06 0.000720382374226452 0.999747347145022 0.999261820436506 0.999947893876346 20 Assoc w RI Evidence from ALL dataset only 2) Assoc w R - Interim No change yes ALL only 1 +Streptomycin gid p.Gly73Arg gid_p.Gly73Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 5 4 48 30 10320 15578 0.00462962962962962 0.00341543741623323 0.00613358439529863 0.998077908764736 0.997257222940417 0.998702808978616 0.615384615384615 0.498330971153094 0.723398370511166 0.555555555555555 0.212008506778868 0.863004337734833 0.142857142857142 0.0480607784036389 0.302571351690951 1.88687015503875 0.405987695284421 9.51142851602366 0.49799110982978 426 2512 False False 2.41519379844961 1.49826052333168 3.95090494957109 0.000484261501210653 0.00015725649077223 0.00112973990535727 0.998077908764736 0.997257222940417 0.998702808978616 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 1 4 7735 11870 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999663129526697 0.999137704464366 0.999908206750254 0.2 0.00505076337946806 0.716417936118089 0.333333333333333 0.00840375865961264 0.905700675949754 0.2 0.00505076337946806 0.716417936118089 0.767291531997414 0.0130092996606408 14.7419707962822 1 1095.5 2071 False False 0 0 0 0 0 0 0 0.383645765998707 0.00779364023519555 3.87797408017955 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999663129526697 0.999137704464366 0.999908206750254 37 3) Uncertain significance No change no 1 +Streptomycin gid p.Gly73Glu gid_p.Gly73Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 12 11 1 14 2 10354 15606 0.0013503086419753 0.00073841672613154 0.00226455162408295 0.999871860584315 0.999537193839207 0.999984481345552 0.875 0.616523763150736 0.984486396184586 0.916666666666666 0.615203834849055 0.997892406768139 0.846153846153846 0.545528944323442 0.980793328017471 16.5796793509754 2.40888791376956 711.311612598203 0.000310360611027923 41 2512 True False 10.5507050415298 2.42225656707454 95.6828054879443 0.00106126386878919 0.000529894376832165 0.00189809895407166 0.999871860584315 0.999537193839207 0.999984481345552 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 12 11 1 14 2 7722 11872 0.00180972078593588 0.000989733300678632 0.0030345415962221 0.999831564763348 0.99939168785815 0.999979601060482 0.875 0.616523763150736 0.984486396184586 0.916666666666666 0.615203834849055 0.997892406768139 0.846153846153846 0.545528944323442 0.980793328017471 16.9116809116809 2.4568328070059 725.514974545464 0.000274281348642848 34 2071 True False 0 0 0 0 0 0 0 10.7619787619787 2.47043198487131 97.6065369101353 0.00142247510668563 0.000710301580771 0.00254377217813781 0.999831564763348 0.99939168785815 0.999979601060482 4 1) Assoc w R New AwR yes 5 +Streptomycin gid p.Gly73Trp gid_p.Gly73Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0385973247056878 Inf 0.399153031761308 409.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0393529118200762 Inf 0.394512723749298 338.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance No change no 1 +Streptomycin gid p.Gly73Val gid_p.Gly73Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0386035211949905 Inf 0.399114533205004 308.5 2512 False False Inf 0.282736080598822 Inf 9.64599209028648e-05 2.44215077354346e-06 0.000537321795461189 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0393613144801391 Inf 0.394461726758121 237.5 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0.000129282482223658 3.27314370392442e-06 0.000720103058325324 1 0.999689379610589 1 1 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Gly76Ala gid_p.Gly76Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Gly76Arg gid_p.Gly76Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 0.5 0.012579117093425 0.987420882906574 0.333333333333333 0.00840375865961264 0.905700675949754 1.5053535256101 0.0191825093710452 118.067140430791 1 973.5 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0393529118200762 Inf 0.394512723749298 338.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance No change no 1 +Streptomycin gid p.Gly76Asp gid_p.Gly76Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 3 0 5 0 10363 15608 0.000482253086419753 0.000156604214122162 0.00112505595550109 1 0.99976368249849 1 1 0.478176249895018 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.622249211987883 Inf 0.0635538067882081 110.5 2512 False False Inf 1.37979907306709 Inf 0.000289407678950414 5.96867980365928e-05 0.000845536799804338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 3 0 5 0 7731 11874 0.000646328852119958 0.0002098934625097 0.00150766595359595 1 0.999689379610589 1 1 0.478176249895018 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.634502337148785 Inf 0.0613494364773578 91 2071 False False 0 0 0 0 0 0 0 Inf 1.40693962335604 Inf 0.00038789759503491 8.00009542696687e-05 0.00113317878297119 1 0.999689379610589 1 11 3) Uncertain significance No change no 1 +Streptomycin gid p.Gly76Cys gid_p.Gly76Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1563 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Gly76fs gid_p.Gly76fs 1 frameshift (see "Genomic_coordinates" sheet) 1 3 3 0 3 0 10365 15608 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 1 0.99976368249849 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.622129167636411 Inf 0.06357591560857 116 2512 False False Inf 0.622129167636411 Inf 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Gly76Ser gid_p.Gly76Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 1 6 1 6 10367 15602 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999615581752947 0.999163472525571 0.999858912630967 0.142857142857142 0.00361029686190058 0.578723197043195 0.142857142857142 0.00361029686190058 0.578723197043195 0.142857142857142 0.00361029686190058 0.578723197043195 0.250827947654416 0.00545680578940276 2.0680301831463 0.255118710755198 218 2512 False False 0.250827947654416 0.00545680578940276 2.0680301831463 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999615581752947 0.999163472525571 0.999858912630967 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 1 4 1 4 7735 11870 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999663129526697 0.999137704464366 0.999908206750254 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 0.383645765998707 0.00779364023519555 3.87797408017955 0.654465279037393 494 2071 False False 0 0 0 0 0 0 0 0.383645765998707 0.00779364023519555 3.87797408017955 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999663129526697 0.999137704464366 0.999908206750254 3 3) Uncertain significance No change no 1 +Streptomycin gid p.Gly76Val gid_p.Gly76Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1618 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1333 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 1 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.His168Arg gid_p.His168Arg 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 0 1 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 58.6634076928655 1 973.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1340 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.His168Asp gid_p.His168Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin gid p.His168fs gid_p.His168fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.His174Arg gid_p.His174Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1607 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1323 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 2 3) Uncertain significance No change no 1 +Streptomycin gid p.His174Asn gid_p.His174Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1638 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1349 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.His174Asp gid_p.His174Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 2 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.His174fs gid_p.His174fs 1 frameshift (see "Genomic_coordinates" sheet) 1 5 3 2 3 3 10365 15605 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999807790876473 0.99943838714673 0.999960360103688 0.5 0.118117248757025 0.881882751242974 0.6 0.146632799634673 0.947255049473683 0.5 0.118117248757025 0.881882751242974 2.25832127351664 0.258641393067499 27.0459566057571 0.394254432342508 290 2512 False False 1.50554751567776 0.201606412693291 11.2464963121379 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 2 2 2 3 7734 11871 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999747347145022 0.999261820436506 0.999947893876346 0.4 0.0527449505263169 0.853367200365326 0.5 0.067585986488543 0.932414013511457 0.4 0.0527449505263169 0.853367200365326 1.53491078355314 0.111219596320004 21.1765312831251 0.649684606669322 487.5 2071 False False 0 0 0 0 0 0 0 1.02327385570209 0.0854221600622099 8.93608975066686 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999747347145022 0.999261820436506 0.999947893876346 10 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.His174Pro gid_p.His174Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.His174Tyr gid_p.His174Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Streptomycin gid p.His48Arg gid_p.His48Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 58.6540000158548 1 973.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 59.801132462225 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 8 3) Uncertain significance No change no 1 +Streptomycin gid p.His48Asn gid_p.His48Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 2 3 8 5 10360 15603 0.000771604938271604 0.00033318123262376 0.00151980017311994 0.999679651460789 0.999252573060182 0.999895975781355 0.615384615384615 0.315777602914063 0.861420661109839 0.4 0.0527449505263169 0.853367200365326 0.285714285714285 0.0366925661760855 0.709579136262657 1.00405405405405 0.0838218466499393 8.76766578232497 1 973.5 2512 False False 2.40972972972972 0.694822005291174 9.3658001588517 0.000193012931866435 2.337561626619e-05 0.000697053319347772 0.999679651460789 0.999252573060182 0.999895975781355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 1 3 7 3 7729 11871 0.000904860392967942 0.000363875741427306 0.00186346392020999 0.999747347145022 0.999261820436506 0.999947893876346 0.7 0.347547149940002 0.933260488822265 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.511967913054729 0.00975577936832002 6.37776925343821 1 806.5 2071 False False 0 0 0 0 0 0 0 3.5837753913831 0.81778515516938 21.4815595723006 0.000129366106080207 3.27526086973536e-06 0.000720568705238285 0.999747347145022 0.999261820436506 0.999947893876346 19 3) Uncertain significance No change no 1 +Streptomycin gid p.His48Asp gid_p.His48Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 10366 15607 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999935930292158 0.99964307871082 0.999998377896754 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 58.6690617185945 1 973.5 2512 False False 3.01119043025274 0.156729426968348 177.474331043773 0 0 0.000355800035063835 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Streptomycin gid p.His48fs gid_p.His48fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.His48Gln gid_p.His48Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 22 18 4 20 5 10348 15603 0.00192901234567901 0.00117867659406302 0.00297763858885685 0.999679651460789 0.999252573060182 0.999895975781355 0.8 0.592962567721322 0.931688535987516 0.818181818181818 0.597154216922128 0.948132700687563 0.782608695652174 0.562969273763185 0.925396592351196 6.78522419791264 2.23408191685842 27.5704563068137 8.57382045611977e-05 36 2512 True False 6.03131039814456 2.19543954736583 20.5692629135065 0.00173644607370248 0.00102944252093236 0.00274295033631364 0.999679651460789 0.999252573060182 0.999895975781355 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 22 18 4 20 5 7716 11869 0.00258531540847983 0.00157987085455139 0.00398999964984359 0.999578911908371 0.999017596768841 0.999863260157969 0.8 0.592962567721322 0.931688535987516 0.818181818181818 0.597154216922128 0.948132700687563 0.782608695652174 0.562969273763185 0.925396592351196 6.92204510108864 2.27879482297336 28.1158169006578 7.59835858021007e-05 31 2071 True False 0 0 0 0 0 0 0 6.15292897874546 2.23942109938919 20.9858092294498 0.00232738557020946 0.00137992134883809 0.00367578789656624 0.999578911908371 0.999017596768841 0.999863260157969 11 1) Assoc w R UP from Uncertain to AwR yes 4 +Streptomycin gid p.His48Pro gid_p.His48Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 4 0 4 0 10364 15608 0.000385802469135802 0.000105127872737001 0.000987510251175401 1 0.99976368249849 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 0.993868422549659 Inf 0.0253711302230326 86 2512 False False Inf 0.993868422549659 Inf 0.000385802469135802 0.000105127872737001 0.000987510251175401 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 8 3) Uncertain significance No change no 1 +Streptomycin gid p.His48Tyr gid_p.His48Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 12 8 4 8 6 10360 15602 0.000771604938271604 0.00033318123262376 0.00151980017311994 0.999615581752947 0.999163472525571 0.999858912630967 0.571428571428571 0.288609400038307 0.823388910017882 0.666666666666666 0.348875506418814 0.900753908850416 0.571428571428571 0.288609400038307 0.823388910017882 3.01196911196911 0.806631339682296 13.6688635087216 0.0764089802371536 120 2512 False False 2.0079794079794 0.610786281740427 7.02280188964479 0.000771604938271604 0.00033318123262376 0.00151980017311994 0.999615581752947 0.999163472525571 0.999858912630967 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 1 4 7735 11870 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999663129526697 0.999137704464366 0.999908206750254 0.2 0.00505076337946806 0.716417936118089 0.333333333333333 0.00840375865961264 0.905700675949754 0.2 0.00505076337946806 0.716417936118089 0.767291531997414 0.0130092996606408 14.7419707962822 1 1095.5 2071 False False 0 0 0 0 0 0 0 0.383645765998707 0.00779364023519555 3.87797408017955 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999663129526697 0.999137704464366 0.999908206750254 15 3) Uncertain significance No change no 1 +Streptomycin gid p.Ile114Asn gid_p.Ile114Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 3 1 10365 15607 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999935930292158 0.99964307871082 0.999998377896754 0.75 0.194120449683243 0.99369053679029 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.50574047274481 0.0191874378630812 118.097459292191 1 973.5 2512 False False 4.51722141823444 0.362625225225282 236.854590713406 9.64692263168049e-05 2.44238636565143e-06 0.000537373619049235 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1392 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0 0 0.000476855424503066 1 0.999689379610589 1 1 3) Uncertain significance No change no 1 +Streptomycin gid p.Ile114fs gid_p.Ile114fs 1 frameshift (see "Genomic_coordinates" sheet) 1 4 2 2 3 2 10365 15606 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999871860584315 0.999537193839207 0.999984481345552 0.6 0.146632799634673 0.947255049473683 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 1.50564399421128 0.109104436422922 20.7716591510574 0.65362265655461 581.5 2512 False False 2.25846599131693 0.258657968313028 27.0476864113414 0.000192919841805729 2.33643418036207e-05 0.000696717215522511 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 2 2 3 2 7733 11872 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 0.999831564763348 0.99939168785815 0.999979601060482 0.6 0.146632799634673 0.947255049473683 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 1.53523858787016 0.111243351068146 21.1810563906676 0.649641371350739 483.5 2071 False False 0 0 0 0 0 0 0 2.30285788180525 0.263724298106321 27.579548092527 0.000258564964447317 3.13149507641486e-05 0.00093371015947595 0.999831564763348 0.99939168785815 0.999979601060482 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Ile114Met gid_p.Ile114Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Ile114Phe gid_p.Ile114Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Ile114Ser gid_p.Ile114Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Ile11Asn gid_p.Ile11Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Ile11fs gid_p.Ile11fs 1 frameshift (see "Genomic_coordinates" sheet) 1 5 4 1 11 4 10357 15604 0.00106095679012345 0.000529741017552837 0.00189754996565939 0.999743721168631 0.999343955596995 0.999930168370675 0.733333333333333 0.448996758963029 0.922128453708956 0.8 0.28358206388191 0.994949236620532 0.5 0.157012770487058 0.842987229512941 6.02645553731775 0.596224896371172 296.357607517505 0.0862702377288621 122 2512 False False 4.14318818190595 1.22719918637044 17.8375204370869 0.000386063121320335 0.000105198904776246 0.000988177222462061 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 3 1 10 4 7726 11870 0.00129265770423991 0.000620048157733657 0.00237595446225449 0.999663129526697 0.999137704464366 0.999908206750254 0.714285714285714 0.418964742816338 0.916110681692872 0.75 0.194120449683243 0.99369053679029 0.428571428571428 0.0989882784425078 0.815948432359917 4.60911208904996 0.369976113154401 241.670333867485 0.307250036046734 211 2071 False False 0 0 0 0 0 0 0 3.84092674087496 1.10725979503529 16.7765671286618 0.000388148531504722 8.00527126502773e-05 0.00113391157892271 0.999663129526697 0.999137704464366 0.999908206750254 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Ile11Ser gid_p.Ile11Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Ile11Thr gid_p.Ile11Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance No change no 1 +Streptomycin gid p.Ile153Thr gid_p.Ile153Thr 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 0 1 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 58.6634076928655 1 973.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 0 1 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 59.8138891519084 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Ile162Ser gid_p.Ile162Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Ile179fs gid_p.Ile179fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Ile179Ser gid_p.Ile179Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1643 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1355 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Ile179Val gid_p.Ile179Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Ile4_Pro38del gid_p.Ile4_Pro38del 1 inframe_deletion (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1677 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1387 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Streptomycin gid p.Ile55dup gid_p.Ile55dup 1 inframe_insertion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Streptomycin gid p.Ile55Val gid_p.Ile55Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Ile68Asn gid_p.Ile68Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1624 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1341 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Ile68Lys gid_p.Ile68Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1578 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1298 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Ile68Phe gid_p.Ile68Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Ile68Ser gid_p.Ile68Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 4 0 4 0 10364 15608 0.000385802469135802 0.000105127872737001 0.000987510251175401 1 0.99976368249849 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 0.993868422549659 Inf 0.0253711302230326 86 2512 False False Inf 0.993868422549659 Inf 0.000385802469135802 0.000105127872737001 0.000987510251175401 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 4 0 4 0 7732 11874 0.000517063081695967 0.000140899683864147 0.00132335286075948 1 0.999689379610589 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 1.01342344657205 Inf 0.0242075852391605 68 2071 False False 0 0 0 0 0 0 0 Inf 1.01342344657205 Inf 0.000517063081695967 0.000140899683864147 0.00132335286075948 1 0.999689379610589 1 2 3) Uncertain significance No change no 1 +Streptomycin gid p.Ile81Arg gid_p.Ile81Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 1 3 10367 15605 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999807790876473 0.99943838714673 0.999960360103688 0.25 0.00630946320970987 0.805879550316756 0.333333333333333 0.00840375865961264 0.905700675949754 0.25 0.00630946320970987 0.805879550316756 0.752628532844603 0.0127612189150725 14.4596792780633 1 973.5 2512 False False 0.501752355229735 0.00956153582768186 6.25014259670444 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0393529118200762 Inf 0.394512723749298 338.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance No change no 1 +Streptomycin gid p.Ile81fs gid_p.Ile81fs 1 frameshift (see "Genomic_coordinates" sheet) 1 4 4 0 4 0 10364 15608 0.000385802469135802 0.000105127872737001 0.000987510251175401 1 0.99976368249849 1 1 0.397635364383525 1 1 0.397635364383525 1 1 0.397635364383525 1 Inf 0.993868422549659 Inf 0.0253711302230326 86 2512 False False Inf 0.993868422549659 Inf 0.000385802469135802 0.000105127872737001 0.000987510251175401 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 3 0 3 0 7733 11874 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 1 0.999689379610589 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.634338273987677 Inf 0.0613782650697297 96 2071 False False 0 0 0 0 0 0 0 Inf 0.634338273987677 Inf 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 1 0.999689379610589 1 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Ile81Met gid_p.Ile81Met 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1599 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1316 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Ile81Thr gid_p.Ile81Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 2 1 2 1 10366 15607 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999935930292158 0.99964307871082 0.999998377896754 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 3.01119043025274 0.156729426968348 177.474331043773 0.567669114955046 570 2512 False False 3.01119043025274 0.156729426968348 177.474331043773 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 2 1 2 1 7734 11873 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999915782381674 0.999530859783396 0.999997867796783 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 3.07033876389966 0.159799628612092 180.959738606129 0.566060794245423 475.5 2071 False False 0 0 0 0 0 0 0 3.07033876389966 0.159799628612092 180.959738606129 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999915782381674 0.999530859783396 0.999997867796783 12 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Leu101Arg gid_p.Leu101Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 7 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Leu101Phe gid_p.Leu101Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 3 3 4 4 10364 15604 0.000385802469135802 0.000105127872737001 0.000987510251175401 0.999743721168631 0.999343955596995 0.999930168370675 0.5 0.157012770487058 0.842987229512941 0.5 0.118117248757025 0.881882751242974 0.428571428571428 0.0989882784425078 0.815948432359917 1.50559629486684 0.201612941136541 11.2468606980362 0.688481304516105 591 2512 False False 1.50559629486684 0.280357681374081 8.08594018183047 0.000289379762708594 5.96810402691469e-05 0.000845455262078775 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 2 3 3 3 7733 11871 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 0.999747347145022 0.999261820436506 0.999947893876346 0.5 0.118117248757025 0.881882751242974 0.4 0.0527449505263169 0.853367200365326 0.4 0.0527449505263169 0.853367200365326 1.02340618130091 0.0854332067543184 8.93724596573217 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53510927195137 0.205550714955708 11.4678941037862 0.000258564964447317 3.13149507641486e-05 0.00093371015947595 0.999747347145022 0.999261820436506 0.999947893876346 11 3) Uncertain significance No change no 1 +Streptomycin gid p.Leu101Pro gid_p.Leu101Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Leu101Val gid_p.Leu101Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 3 0 3 0 10365 15608 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 1 0.99976368249849 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.622129167636411 Inf 0.06357591560857 116 2512 False False Inf 0.622129167636411 Inf 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 3 0 3 0 7733 11874 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 1 0.999689379610589 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.634338273987677 Inf 0.0613782650697297 96 2071 False False 0 0 0 0 0 0 0 Inf 0.634338273987677 Inf 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 1 0.999689379610589 1 1 3) Uncertain significance No change no 1 +Streptomycin gid p.Leu108Arg gid_p.Leu108Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 10 3 7 5 7 10363 15601 0.000482253086419753 0.000156604214122162 0.00112505595550109 0.999551512045105 0.999076163117038 0.999819666176692 0.416666666666666 0.15165222980843 0.723330314317894 0.3 0.0667395111777345 0.652452850059997 0.3 0.0667395111777345 0.652452850059997 0.645193752498587 0.107605668583626 2.82702906406885 0.749133329249056 595 2512 False False 1.07532292083097 0.269031203663503 3.93708315605966 0.000289407678950414 5.96867980365928e-05 0.000845536799804338 0.999551512045105 0.999076163117038 0.999819666176692 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1367 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 27 3) Uncertain significance No change no 1 +Streptomycin gid p.Leu108fs gid_p.Leu108fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Leu108Pro gid_p.Leu108Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 1 4 4 5 10364 15603 0.000385802469135802 0.000105127872737001 0.000987510251175401 0.999679651460789 0.999252573060182 0.999895975781355 0.444444444444444 0.136995662265166 0.787991493221131 0.2 0.00505076337946806 0.716417936118089 0.166666666666666 0.00421074451448947 0.641234578997674 0.376374951756078 0.00764628098079035 3.80420690669586 0.65436972907308 587 2512 False False 1.20439984561945 0.238927818072029 5.59645851293522 9.64785335262904e-05 2.44262200321851e-06 0.000537425452634802 0.999679651460789 0.999252573060182 0.999895975781355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 1 4 7735 11870 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999663129526697 0.999137704464366 0.999908206750254 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.32543092899395 0.158624932919193 149.5 2071 False False 0 0 0 0 0 0 0 0.383645765998707 0.00779364023519555 3.87797408017955 0 0 0.000476793790149404 0.999663129526697 0.999137704464366 0.999908206750254 3 3) Uncertain significance No change no 1 +Streptomycin gid p.Leu108Val gid_p.Leu108Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1595 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Leu128Ser gid_p.Leu128Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.50544998553101 0.0191837380556942 118.074698097101 1 973.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 3 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Leu142Phe gid_p.Leu142Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 58.6540000158548 1 973.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 59.801132462225 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 4 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Leu142Ser gid_p.Leu142Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.282736080598822 Inf 0.159301643065502 181.5 2512 False False Inf 0.282736080598822 Inf 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.288279755767314 Inf 0.155612234482449 125.5 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 3) Uncertain significance No change no 1 +Streptomycin gid p.Leu142Trp gid_p.Leu142Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0385973247056878 Inf 0.399153031761308 409.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1350 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance No change no 1 +Streptomycin gid p.Leu145Phe gid_p.Leu145Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 39 10 29 13 31 10355 15577 0.00125385802469135 0.000667790166179422 0.00214318097672708 0.998013839056894 0.997181977555192 0.998650113371875 0.295454545454545 0.167643981228676 0.452021848084055 0.256410256410256 0.130376799235587 0.421273884378569 0.24390243902439 0.123632488395844 0.40304623662365 0.518723255465458 0.225436349471539 1.09563247826245 0.0731971184721046 119 2512 False False 0.630834410678961 0.30284136582868 1.2416019808367 0.000964785335262904 0.000462745943899107 0.0017735564881541 0.998013839056894 0.997181977555192 0.998650113371875 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17379939830658 0.52225229054203 453 2071 False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 0 0 0.000476793790149404 0.999831564763348 0.99939168785815 0.999979601060482 8 3) Uncertain significance No change no 1 +Streptomycin gid p.Leu145Ser gid_p.Leu145Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 3 2 5 3 10363 15605 0.000482253086419753 0.000156604214122162 0.00112505595550109 0.999807790876473 0.99943838714673 0.999960360103688 0.625 0.244863216366551 0.914766585862746 0.6 0.146632799634673 0.947255049473683 0.5 0.118117248757025 0.881882751242974 2.25875711666505 0.258691301858568 27.0511668878721 0.394204743099109 285 2512 False False 2.50973012962784 0.48813575589439 16.1645252811411 0.000289407678950414 5.96867980365928e-05 0.000845536799804338 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 3 2 5 3 7731 11871 0.000646328852119958 0.0002098934625097 0.00150766595359595 0.999747347145022 0.999261820436506 0.999947893876346 0.625 0.244863216366551 0.914766585862746 0.6 0.146632799634673 0.947255049473683 0.5 0.118117248757025 0.881882751242974 2.30325960419091 0.26377036606342 27.5843523837602 0.389273772526771 218 2071 False False 0 0 0 0 0 0 0 2.55917733798991 0.497713634211278 16.4842738218502 0.00038789759503491 8.00009542696687e-05 0.00113317878297119 0.999747347145022 0.999261820436506 0.999947893876346 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Leu152_Arg154dup gid_p.Leu152_Arg154dup 1 inframe_insertion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Streptomycin gid p.Leu152fs gid_p.Leu152fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 58.6502452744631 1 973.5 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 59.7961004349848 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 3.71438150990605 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 12 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Leu152Ser gid_p.Leu152Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 4 2 5 2 10363 15606 0.000482253086419753 0.000156604214122162 0.00112505595550109 0.999871860584315 0.999537193839207 0.999984481345552 0.714285714285714 0.290420863737342 0.963307433823914 0.666666666666666 0.222778095503512 0.956728131707258 0.666666666666666 0.222778095503512 0.956728131707258 3.01186914986007 0.431544912878221 33.3073857873502 0.225004152886249 210.5 2512 False False 3.76483643732509 0.616187094146839 39.5416182494222 0.000385839683611459 0.000105138014297713 0.000987605477659245 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 3 0 7733 11874 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 1 0.999689379610589 1 1 0.292401773821286 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.288317028192402 Inf 0.155587872029136 119.5 2071 False False 0 0 0 0 0 0 0 Inf 0.634338273987677 Inf 0.000258564964447317 3.13149507641486e-05 0.00093371015947595 1 0.999689379610589 1 4 3) Uncertain significance No change no 1 +Streptomycin gid p.Leu160Arg gid_p.Leu160Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.282736080598822 Inf 0.159301643065502 181.5 2512 False False Inf 0.282736080598822 Inf 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Streptomycin gid p.Leu160Phe gid_p.Leu160Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 4 3) Uncertain significance No change no 1 +Streptomycin gid p.Leu160Pro gid_p.Leu160Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1665 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1376 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 8 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Leu160Val gid_p.Leu160Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Leu16Arg gid_p.Leu16Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 12 1 11 1092 2430 9276 13178 0.105324074074074 0.0994785172031747 0.111392329709777 0.844310609943618 0.838526549746732 0.849966034311094 0.310051107325383 0.294797074937641 0.325621033899431 0.0833333333333333 0.00210759323186022 0.384796165150944 0.000411353352529823 1.04145109616481e-05 0.00228976030706963 0.129150495903406 0.00300439270855003 0.88894523829465 0.0195151838349708 NA NA False True 0.638418006910173 0.591013762670203 0.689362687802259 0.000107793467715856 2.72909059361629e-06 0.000600438800320738 0.844310609943618 0.838526549746732 0.849966034311094 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 11 0 11 679 1630 7057 10244 0.0877714581178903 0.0815575167887963 0.0942979714329055 0.862725282129021 0.856404375305036 0.868867790257528 0.294066695539194 0.275536960948167 0.313120305706846 0 0 0.284914152918154 0 0 0.00226055731272297 0 0 0.578627407202002 0.00401854151012674 NA NA False True 0 0 0 0 1 1 0 0.604688378853698 0.549289454050899 0.665146349703013 0 0 0.00052258969603839 0.862725282129021 0.856404375305036 0.868867790257528 2874 Not assoc w R Not assoc w R 5) Not assoc w R No change yes 1 +Streptomycin gid p.Leu16fs gid_p.Leu16fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 58.6634076928655 1 973.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 59.8138891519084 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Leu16Pro gid_p.Leu16Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 1 10366 15607 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999935930292158 0.99964307871082 0.999998377896754 0.666666666666666 0.0942993240502461 0.991596241340387 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0386010478475006 Inf 0.399129899129899 318 2512 False False 3.01119043025274 0.156729426968348 177.474331043773 9.64599209028648e-05 2.44215077354346e-06 0.000537321795461189 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0393613144801391 Inf 0.394461726758121 237.5 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0.000129282482223658 3.27314370392442e-06 0.000720103058325324 1 0.999689379610589 1 6 3) Uncertain significance No change no 1 +Streptomycin gid p.Leu18Arg gid_p.Leu18Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 2 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Leu26fs gid_p.Leu26fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 4 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Leu26Phe gid_p.Leu26Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 13 8 5 9 7 10359 15601 0.000868055555555555 0.000397004661559041 0.00164719739830421 0.999551512045105 0.999076163117038 0.999819666176692 0.5625 0.298776899083177 0.802465859467332 0.615384615384615 0.315777602914063 0.861420661109839 0.533333333333333 0.265861347277396 0.787333270480692 2.40965344145187 0.694799985308529 9.36550340090057 0.155069117329586 139 2512 False False 1.93632865830954 0.641428173167175 6.12008165644919 0.000771679367222918 0.000333213376758345 0.00151994671802226 0.999551512045105 0.999076163117038 0.999819666176692 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 2 7734 11872 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999831564763348 0.99939168785815 0.999979601060482 0.5 0.067585986488543 0.932414013511457 1 0.025 1 0.333333333333333 0.00840375865961264 0.905700675949754 Inf 0.0393546845675247 Inf 0.394501963584434 332.5 2071 False False 0 0 0 0 0 0 0 1.53504008275148 0.111228967362952 21.1783159842378 0.000129282482223658 3.27314370392442e-06 0.000720103058325324 0.999831564763348 0.99939168785815 0.999979601060482 4 3) Uncertain significance No change no 1 +Streptomycin gid p.Leu26Ser gid_p.Leu26Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 2 2 4 2 10364 15606 0.000385802469135802 0.000105127872737001 0.000987510251175401 0.999871860584315 0.999537193839207 0.999984481345552 0.666666666666666 0.222778095503512 0.956728131707258 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 1.50578927055191 0.109114964047658 20.7736646113513 0.653602724905766 580 2512 False False 3.01157854110382 0.43150328206235 33.3041852472562 0.000192938452633609 2.33665958259919e-05 0.00069678441035516 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 3 1 7733 11873 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 0.999915782381674 0.999530859783396 0.999997867796783 0.75 0.194120449683243 0.99369053679029 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.53536790378895 0.019556961098611 120.421258157378 1 512 2071 False False 0 0 0 0 0 0 0 4.60610371136686 0.369734697559289 241.512824517625 0.00012929919834497 3.27356691808869e-06 0.000720196139555935 0.999915782381674 0.999530859783396 0.999997867796783 3 3) Uncertain significance No change no 1 +Streptomycin gid p.Leu26* gid_p.Leu26* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Leu26Trp gid_p.Leu26Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 3) Uncertain significance No change no 1 +Streptomycin gid p.Leu35Arg gid_p.Leu35Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 3 0 4 1 10364 15607 0.000385802469135802 0.000105127872737001 0.000987510251175401 0.999935930292158 0.99964307871082 0.999998377896754 0.8 0.28358206388191 0.994949236620532 1 0.292401773821286 1 0.75 0.194120449683243 0.99369053679029 Inf 0.622149319815404 Inf 0.0635722032973131 113 2512 False False 6.02354303357776 0.595936886271208 296.214625622934 0.000289379762708594 5.96810402691469e-05 0.000845455262078775 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 3 0 4 1 7732 11873 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.999915782381674 0.999530859783396 0.999997867796783 0.8 0.28358206388191 0.994949236620532 1 0.292401773821286 1 0.75 0.194120449683243 0.99369053679029 Inf 0.634366863425217 Inf 0.0613732399317593 93.5 2071 False False 0 0 0 0 0 0 0 6.14226590791515 0.607630898004113 302.048561734113 0.000387847446670976 7.99906106240067e-05 0.00113303233742371 0.999915782381674 0.999530859783396 0.999997867796783 9 3) Uncertain significance No change no 1 +Streptomycin gid p.Leu35fs gid_p.Leu35fs 1 frameshift (see "Genomic_coordinates" sheet) 1 194 104 90 181 114 10187 15494 0.017457561728395 0.0150245992952404 0.0201666594131195 0.992696053305997 0.99123218770304 0.993971476123066 0.613559322033898 0.555383282405124 0.669429857614349 0.536082474226804 0.46324322433381 0.60780220883798 0.477064220183486 0.409180463273547 0.545580143718727 1.75755156353958 1.31107340386151 2.35979682868086 0.000117114891712688 37 2512 True False 2.41485450152326 1.89721525178103 3.08424494489553 0.0101059177922456 0.00826452147271505 0.0122318914029003 0.992696053305997 0.99123218770304 0.993971476123066 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance 1 128 67 61 123 79 7613 11795 0.0158996897621509 0.0132311698232272 0.0189413699545265 0.993346808152265 0.991714938892746 0.99472917000824 0.608910891089108 0.537942955318237 0.676632352435628 0.5234375 0.43335249020583 0.61241358504509 0.458904109589041 0.376231998757117 0.543277729174363 1.70171600347119 1.18335487793492 2.45103398753874 0.00350012223437314 44 2071 False False 0 0 0 0 0 0 0 2.41223789420827 1.80082894223162 3.24667474412029 0.00872395833333333 0.00676716142697373 0.0110660549036761 0.993346808152265 0.991714938892746 0.99472917000824 410 Evidence from ALL dataset only 2) Assoc w R - Interim No change no ALL only 1 +Streptomycin gid p.Leu35Gln gid_p.Leu35Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Leu35Met gid_p.Leu35Met 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1625 2512 False False Inf 0.282736080598822 Inf 0 0 0.000355800035063835 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1342 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0 0 0.000476855424503066 1 0.999689379610589 1 6 3) Uncertain significance No change no 1 +Streptomycin gid p.Leu35Pro gid_p.Leu35Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 4 3 10364 15605 0.000385802469135802 0.000105127872737001 0.000987510251175401 0.999807790876473 0.99943838714673 0.999960360103688 0.571428571428571 0.184051567640083 0.901011721557492 1 0.158113883008419 1 0.4 0.0527449505263169 0.853367200365326 Inf 0.282736277902997 Inf 0.159301508760541 174 2512 False False 2.00759037694583 0.339557946095546 13.7090540440321 0.000192938452633609 2.33665958259919e-05 0.00069678441035516 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 3 2 7733 11872 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 0.999831564763348 0.99939168785815 0.999979601060482 0.6 0.146632799634673 0.947255049473683 1 0.025 1 0.333333333333333 0.00840375865961264 0.905700675949754 Inf 0.0393597731583301 Inf 0.394471080281546 246 2071 False False 0 0 0 0 0 0 0 2.30285788180525 0.263724298106321 27.579548092527 0.00012929919834497 3.27356691808869e-06 0.000720196139555935 0.999831564763348 0.99939168785815 0.999979601060482 9 3) Uncertain significance No change no 1 +Streptomycin gid p.Leu44_Asp46delinsHis gid_p.Leu44_Asp46delinsHis 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Streptomycin gid p.Leu44Arg gid_p.Leu44Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance No change no 1 +Streptomycin gid p.Leu44Gln gid_p.Leu44Gln 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 6 0 10362 15608 0.000578703703703703 0.000212402724453782 0.00125916554902567 1 0.99976368249849 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 1619 2512 False False Inf 1.77302352643969 Inf 0 0 0.000355937358633142 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1334 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Leu44Pro gid_p.Leu44Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 2 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Leu49Arg gid_p.Leu49Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 2 10366 15606 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999871860584315 0.999537193839207 0.999984481345552 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 58.6653062545381 1 973.5 2512 False False 1.50549874590005 0.10909391082996 20.7696540777406 0 0 0.000355800035063835 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 2 7734 11872 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999831564763348 0.99939168785815 0.999979601060482 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 59.8165824855725 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53504008275148 0.111228967362952 21.1783159842378 0 0 0.000476855424503066 0.999831564763348 0.99939168785815 0.999979601060482 4 3) Uncertain significance No change no 1 +Streptomycin gid p.Leu49Pro gid_p.Leu49Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 3 1 3 1 10365 15607 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999935930292158 0.99964307871082 0.999998377896754 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 4.51722141823444 0.362625225225282 236.854590713406 0.308516935797272 279.5 2512 False False 4.51722141823444 0.362625225225282 236.854590713406 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 2 1 2 1 7734 11873 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999915782381674 0.999530859783396 0.999997867796783 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 3.07033876389966 0.159799628612092 180.959738606129 0.566060794245423 475.5 2071 False False 0 0 0 0 0 0 0 3.07033876389966 0.159799628612092 180.959738606129 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance No change no 1 +Streptomycin gid p.Leu49Val gid_p.Leu49Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1652 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Streptomycin gid p.Leu50Arg gid_p.Leu50Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 54 27 27 33 34 10335 15574 0.00318287037037037 0.00219192358584956 0.00446705589312306 0.997821629933367 0.996957264071706 0.998490958165439 0.492537313432835 0.368156529286879 0.617598919939473 0.5 0.360809968385006 0.639190031614993 0.442622950819672 0.315464140975931 0.575540487560001 1.50691823899371 0.85007268185889 2.67101767008815 0.163526230255236 191 2512 False False 1.46259711431742 0.877398880793904 2.43525256972008 0.00260567458019687 0.00171783661296156 0.00378887213135622 0.997821629933367 0.996957264071706 0.998490958165439 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 2 1 2 1 7734 11873 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999915782381674 0.999530859783396 0.999997867796783 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 3.07033876389966 0.159799628612092 180.959738606129 0.566060794245423 475.5 2071 False False 0 0 0 0 0 0 0 3.07033876389966 0.159799628612092 180.959738606129 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999915782381674 0.999530859783396 0.999997867796783 27 3) Uncertain significance No change no 1 +Streptomycin gid p.Leu50fs gid_p.Leu50fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Leu50Met gid_p.Leu50Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0386035211949905 Inf 0.399114533205004 308.5 2512 False False Inf 0.282736080598822 Inf 9.64599209028648e-05 2.44215077354346e-06 0.000537321795461189 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0393613144801391 Inf 0.394461726758121 237.5 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0.000129282482223658 3.27314370392442e-06 0.000720103058325324 1 0.999689379610589 1 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Leu50Pro gid_p.Leu50Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 2 5 3 5 10365 15603 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999679651460789 0.999252573060182 0.999895975781355 0.375 0.0852334141372535 0.755136783633448 0.285714285714285 0.0366925661760855 0.709579136262657 0.285714285714285 0.0366925661760855 0.709579136262657 0.602141823444283 0.0573049383834589 3.67895071919147 0.709874457348887 593 2512 False False 0.903212735166425 0.140213309764784 4.64350502715881 0.000192919841805729 2.33643418036207e-05 0.000696717215522511 0.999679651460789 0.999252573060182 0.999895975781355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 1 3 2 3 7734 11871 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999747347145022 0.999261820436506 0.999947893876346 0.4 0.0527449505263169 0.853367200365326 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.511636927851047 0.00974947663174677 6.37364544566016 1 806.5 2071 False False 0 0 0 0 0 0 0 1.02327385570209 0.0854221600622099 8.93608975066686 0.000129282482223658 3.27314370392442e-06 0.000720103058325324 0.999747347145022 0.999261820436506 0.999947893876346 5 3) Uncertain significance No change no 1 +Streptomycin gid p.Leu58Phe gid_p.Leu58Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 1 4 1 9 10367 15599 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.99942337262942 0.998905665124108 0.999736296428239 0.1 0.00252857854446178 0.445016117028195 0.2 0.00505076337946806 0.716417936118089 0.1 0.00252857854446178 0.445016117028195 0.376169576540947 0.00764211172493882 3.80213090746286 0.654368928825607 585 2512 False False 0.167186478462643 0.00381816513248207 1.20692977805764 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.99942337262942 0.998905665124108 0.999736296428239 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 1 4 1 8 7735 11866 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999326259053394 0.998672895689377 0.999709083033384 0.111111111111111 0.00280913674659921 0.482496514917337 0.2 0.00505076337946806 0.716417936118089 0.111111111111111 0.00280913674659921 0.482496514917337 0.383516483516483 0.00779101566099612 3.87666732480147 0.654462090060204 489 2071 False False 0 0 0 0 0 0 0 0.191758241758241 0.00432517143892361 1.43088714399149 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999326259053394 0.998672895689377 0.999709083033384 7 3) Uncertain significance No change no 1 +Streptomycin gid p.Leu58Pro gid_p.Leu58Pro 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Streptomycin gid p.Leu59Arg gid_p.Leu59Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.282736080598822 Inf 0.159301643065502 181.5 2512 False False Inf 0.282736080598822 Inf 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance No change no 1 +Streptomycin gid p.Leu59fs gid_p.Leu59fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.50544998553101 0.0191837380556942 118.074698097101 1 973.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.53497091144149 0.0195519049186736 120.390152361053 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Leu74fs gid_p.Leu74fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Leu74Phe gid_p.Leu74Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 1 3) Uncertain significance No change no 1 +Streptomycin gid p.Leu74Ser gid_p.Leu74Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 5 4 5 4 10363 15604 0.000482253086419753 0.000156604214122162 0.00112505595550109 0.999743721168631 0.999343955596995 0.999930168370675 0.555555555555555 0.212008506778868 0.863004337734833 0.555555555555555 0.212008506778868 0.863004337734833 0.555555555555555 0.212008506778868 0.863004337734833 1.88217697577921 0.404976076282378 9.48775936968954 0.498104762028096 428 2512 False False 1.88217697577921 0.404976076282378 9.48775936968954 0.000482253086419753 0.000156604214122162 0.00112505595550109 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 4 4 4 4 7732 11870 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.999663129526697 0.999137704464366 0.999908206750254 0.5 0.157012770487058 0.842987229512941 0.5 0.157012770487058 0.842987229512941 0.5 0.157012770487058 0.842987229512941 1.53517847904811 0.2858428011503 8.24498486654636 0.720109709970388 501 2071 False False 0 0 0 0 0 0 0 1.53517847904811 0.2858428011503 8.24498486654636 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.999663129526697 0.999137704464366 0.999908206750254 8 3) Uncertain significance No change no 1 +Streptomycin gid p.Leu74* gid_p.Leu74* 1 stop_gained (see "Genomic_coordinates" sheet) 1 5 4 1 10 2 10358 15606 0.000964506172839506 0.000462612020337809 0.00177304351401163 0.999871860584315 0.999537193839207 0.999984481345552 0.833333333333333 0.515862251314033 0.979137474539907 0.8 0.28358206388191 0.994949236620532 0.666666666666666 0.222778095503512 0.956728131707258 6.02664607067001 0.596243758417363 296.366958667489 0.0862644459766872 121 2512 False False 7.53330758833751 1.60478662030748 70.8637470762236 0.00038602586373287 0.000105188751465768 0.000988081885694551 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 4 1 7 2 7729 11872 0.000904860392967942 0.000363875741427306 0.00186346392020999 0.999831564763348 0.99939168785815 0.999979601060482 0.777777777777777 0.399906426283687 0.971855026522101 0.8 0.28358206388191 0.994949236620532 0.666666666666666 0.222778095503512 0.956728131707258 6.14413248803208 0.607815467128051 302.140191724982 0.0827971224582786 100 2071 False False 0 0 0 0 0 0 0 5.37611592702807 1.02318899917199 53.0233103196292 0.000517263675158412 0.000140954352333437 0.00132386604532403 0.999831564763348 0.99939168785815 0.999979601060482 3 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Leu79fs gid_p.Leu79fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Leu79Phe gid_p.Leu79Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 1 6 1 9 10367 15599 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.99942337262942 0.998905665124108 0.999736296428239 0.1 0.00252857854446178 0.445016117028195 0.142857142857142 0.00361029686190058 0.578723197043195 0.1 0.00252857854446178 0.445016117028195 0.250779717693964 0.00545575750537708 2.06763230610041 0.25510254284464 217 2512 False False 0.167186478462643 0.00381816513248207 1.20692977805764 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.99942337262942 0.998905665124108 0.999736296428239 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 9 7736 11865 0 0 0.000476732171726368 0.999242041435068 0.998561648359028 0.999653356368186 0 0 0.336267116879942 0 0 0.4592581264399 0 0 0.336267116879942 0 0 1.3030525168271 0.0877148943534958 107 2071 False False 0 0 0 0 0 0 0 0 0 0.777323095649869 0 0 0.000476732171726368 0.999242041435068 0.998561648359028 0.999653356368186 5 3) Uncertain significance No change no 1 +Streptomycin gid p.Leu79Ser gid_p.Leu79Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 25 12 13 86 26 10282 15582 0.00829475308641975 0.00663993256050197 0.0102339552351286 0.998334187596104 0.997560144791746 0.998911556433689 0.767857142857142 0.67864627492701 0.84240782332799 0.48 0.277968009669946 0.686942955542967 0.31578947368421 0.175025338901126 0.486527054406021 1.39888977002379 0.58318935458298 3.32676275486573 0.418760037809624 420 2512 False False 5.01268834258525 3.19754295864791 8.10473107848166 0.00116572760831552 0.000602488948578675 0.00203540519080232 0.998334187596104 0.997560144791746 0.998911556433689 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 19 9 10 66 23 7670 11851 0.00853154084798345 0.00660426142571422 0.0108415902072273 0.998062994778507 0.99709495013346 0.998771720922747 0.741573033707865 0.637880094385292 0.828596387431762 0.473684210526315 0.244474689466196 0.711356752083001 0.28125 0.137456903295501 0.467471099642934 1.3905997392438 0.499727959380859 3.81001256526224 0.488182523906427 348 2071 False False 0 0 0 0 0 0 0 4.43379627005271 2.71880519546773 7.47541892885154 0.00117202760776142 0.000536061274444059 0.00222370235145422 0.998062994778507 0.99709495013346 0.998771720922747 717 3) Uncertain significance No change no 1 +Streptomycin gid p.Leu79* gid_p.Leu79* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Leu79Trp gid_p.Leu79Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 60 35 25 49 28 10319 15580 0.00472608024691358 0.00349836449874159 0.00624337076827083 0.99820604818042 0.997408275859702 0.998807611281278 0.636363636363636 0.5188485695963 0.743046257776942 0.583333333333333 0.448837797754011 0.709319333529577 0.555555555555555 0.42488762698261 0.680826873728043 2.11377071421649 1.22867006996635 3.68655628803067 0.00512449644800965 58 2512 False False 2.64221339277061 1.62684355631265 4.36902585591755 0.00338033610198956 0.00235562319781279 0.00469812318030948 0.99820604818042 0.997408275859702 0.998807611281278 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 4 7 6 8 7730 11866 0.00077559462254395 0.000284681048736677 0.00168737281383633 0.999326259053394 0.998672895689377 0.999709083033384 0.428571428571428 0.176611089982117 0.711390599961692 0.363636363636363 0.109263443819098 0.692095284988322 0.333333333333333 0.0992460911495833 0.651124493581186 0.877176122712992 0.188243940162922 3.45183313374094 1 512 2071 False False 0 0 0 0 0 0 0 1.1512936610608 0.329114894246618 3.78538806793166 0.000517196793379881 0.000140936124797366 0.00132369493958413 0.999326259053394 0.998672895689377 0.999709083033384 51 3) Uncertain significance No change no 1 +Streptomycin gid p.Leu86Arg gid_p.Leu86Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 2 3 4 3 10364 15605 0.000385802469135802 0.000105127872737001 0.000987510251175401 0.999807790876473 0.99943838714673 0.999960360103688 0.571428571428571 0.184051567640083 0.901011721557492 0.4 0.0527449505263169 0.853367200365326 0.4 0.0527449505263169 0.853367200365326 1.00379518847291 0.0838002347975383 8.76540391741991 1 973.5 2512 False False 2.00759037694583 0.339557946095546 13.7090540440321 0.000192938452633609 2.33665958259919e-05 0.00069678441035516 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 2 3 3 3 7733 11871 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 0.999747347145022 0.999261820436506 0.999947893876346 0.5 0.118117248757025 0.881882751242974 0.4 0.0527449505263169 0.853367200365326 0.4 0.0527449505263169 0.853367200365326 1.02340618130091 0.0854332067543184 8.93724596573217 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53510927195137 0.205550714955708 11.4678941037862 0.000258564964447317 3.13149507641486e-05 0.00093371015947595 0.999747347145022 0.999261820436506 0.999947893876346 3 3) Uncertain significance No change no 1 +Streptomycin gid p.Leu86fs gid_p.Leu86fs 1 frameshift (see "Genomic_coordinates" sheet) 1 3 1 2 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.752676762805054 0.0127620362920002 14.460605698152 1 1332 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Leu86Gln gid_p.Leu86Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Leu86His gid_p.Leu86His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 3) Uncertain significance No change no 1 +Streptomycin gid p.Leu86Phe gid_p.Leu86Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 1 7 4 9 10364 15599 0.000385802469135802 0.000105127872737001 0.000987510251175401 0.99942337262942 0.998905665124108 0.999736296428239 0.307692307692307 0.0909203945720966 0.614261661750705 0.125 0.0031597235312519 0.526509670875206 0.1 0.00252857854446178 0.445016117028195 0.215016265093455 0.0047745798829038 1.67411543162181 0.156509728066281 166 2512 False False 0.668939491401861 0.150491714930531 2.39753666739202 9.64785335262904e-05 2.44262200321851e-06 0.000537425452634802 0.99942337262942 0.998905665124108 0.999736296428239 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 1 5 4 6 7732 11868 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.999494694290045 0.998900489118281 0.999814539856352 0.4 0.121552258119827 0.737621923393055 0.166666666666666 0.00421074451448947 0.641234578997674 0.142857142857142 0.00361029686190058 0.578723197043195 0.306983962752198 0.00649397896194236 2.74427715541279 0.413560165886949 346 2071 False False 0 0 0 0 0 0 0 1.02327987584066 0.212320035147848 4.31668986259282 0.000129315918789603 3.27399024170944e-06 0.000720289244853199 0.999494694290045 0.998900489118281 0.999814539856352 4 3) Uncertain significance No change no 1 +Streptomycin gid p.Leu86Pro gid_p.Leu86Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 4 2 4 2 10364 15606 0.000385802469135802 0.000105127872737001 0.000987510251175401 0.999871860584315 0.999537193839207 0.999984481345552 0.666666666666666 0.222778095503512 0.956728131707258 0.666666666666666 0.222778095503512 0.956728131707258 0.666666666666666 0.222778095503512 0.956728131707258 3.01157854110382 0.43150328206235 33.3041852472562 0.225025147686288 214 2512 False False 3.01157854110382 0.43150328206235 33.3041852472562 0.000385802469135802 0.000105127872737001 0.000987510251175401 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 4 2 4 2 7732 11872 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.999831564763348 0.99939168785815 0.999979601060482 0.666666666666666 0.222778095503512 0.956728131707258 0.666666666666666 0.222778095503512 0.956728131707258 0.666666666666666 0.222778095503512 0.956728131707258 3.07087428867046 0.439962791152193 33.9588674822466 0.220899461844046 170 2071 False False 0 0 0 0 0 0 0 3.07087428867046 0.439962791152193 33.9588674822466 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.999831564763348 0.99939168785815 0.999979601060482 15 3) Uncertain significance No change no 1 +Streptomycin gid p.Leu90Arg gid_p.Leu90Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 25 10 15 30 23 10338 15585 0.00289351851851851 0.00195307029853899 0.00412812175097628 0.998526396719631 0.997789687011067 0.999065639764335 0.566037735849056 0.422825832379029 0.701607879512447 0.4 0.211254806465142 0.61334650374316 0.303030303030303 0.155916602396985 0.487110697538393 1.00502998645772 0.403592540323231 2.39245285202909 1 973.5 2512 False False 1.96636301698251 1.10369034107262 3.54674124291773 0.000966370313103981 0.000463506311135223 0.00177646895754269 0.998526396719631 0.997789687011067 0.999065639764335 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 4 2 7732 11872 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.999831564763348 0.99939168785815 0.999979601060482 0.666666666666666 0.222778095503512 0.956728131707258 0.5 0.012579117093425 0.987420882906574 0.333333333333333 0.00840375865961264 0.905700675949754 1.53543714433523 0.0195578427502557 120.426684243042 1 806.5 2071 False False 0 0 0 0 0 0 0 3.07087428867046 0.439962791152193 33.9588674822466 0.000129315918789603 3.27399024170944e-06 0.000720289244853199 0.999831564763348 0.99939168785815 0.999979601060482 23 3) Uncertain significance No change no 1 +Streptomycin gid p.Leu90fs gid_p.Leu90fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1668 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Leu90Ile gid_p.Leu90Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 10365 15608 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 1 0.99976368249849 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1623 2512 False False Inf 0.622129167636411 Inf 0 0 0.000355834356021348 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Leu90Phe gid_p.Leu90Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 2 2 10366 15606 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999871860584315 0.999537193839207 0.999984481345552 0.5 0.067585986488543 0.932414013511457 0.5 0.012579117093425 0.987420882906574 0.333333333333333 0.00840375865961264 0.905700675949754 1.50549874590005 0.019184358977771 118.078519203969 1 973.5 2512 False False 1.50549874590005 0.10909391082996 20.7696540777406 9.64599209028648e-05 2.44215077354346e-06 0.000537321795461189 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 0.5 0.012579117093425 0.987420882906574 0.333333333333333 0.00840375865961264 0.905700675949754 1.53484162895927 0.0195502581384442 120.380023442175 1 806.5 2071 False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 3 3) Uncertain significance No change no 1 +Streptomycin gid p.Leu90Pro gid_p.Leu90Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 3 1 10365 15607 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999935930292158 0.99964307871082 0.999998377896754 0.75 0.194120449683243 0.99369053679029 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.50574047274481 0.0191874378630812 118.097459292191 1 973.5 2512 False False 4.51722141823444 0.362625225225282 236.854590713406 9.64692263168049e-05 2.44238636565143e-06 0.000537373619049235 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 3 0 7733 11874 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 1 0.999689379610589 1 1 0.292401773821286 1 1 0.025 1 1 0.025 1 Inf 0.0393664039281761 Inf 0.394430844553243 227 2071 False False 0 0 0 0 0 0 0 Inf 0.634338273987677 Inf 0.00012929919834497 3.27356691808869e-06 0.000720196139555935 1 0.999689379610589 1 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Leu90Val gid_p.Leu90Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 9 10368 15599 0 0 0.000355731413006942 0.99942337262942 0.998905665124108 0.999736296428239 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1552 2512 False False 0 0 0.762426796904344 0 0 0.000355731413006942 0.99942337262942 0.998905665124108 0.999736296428239 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 7736 11868 0 0 0.000476732171726368 0.999494694290045 0.998900489118281 0.999814539856352 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1276 2071 False False 0 0 0 0 0 0 0 0 0 1.30338194607257 0 0 0.000476732171726368 0.999494694290045 0.998900489118281 0.999814539856352 28 3) Uncertain significance No change no 1 +Streptomycin gid p.Leu91Arg gid_p.Leu91Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 7 2 8 2 10360 15606 0.000771604938271604 0.00033318123262376 0.00151980017311994 0.999871860584315 0.999537193839207 0.999984481345552 0.8 0.443904537692358 0.974789273673166 0.777777777777777 0.399906426283687 0.971855026522101 0.777777777777777 0.399906426283687 0.971855026522101 5.27229729729729 1.00353317562171 52.0030798022018 0.0348904882265159 94 2512 False False 6.02548262548262 1.20205596098606 58.1705362675123 0.000675219446320054 0.000271514958917607 0.00139071212018862 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 7 2 8 2 7728 11872 0.00103412616339193 0.000446564649135067 0.00203661849802302 0.999831564763348 0.99939168785815 0.999979601060482 0.8 0.443904537692358 0.974789273673166 0.777777777777777 0.399906426283687 0.971855026522101 0.777777777777777 0.399906426283687 0.971855026522101 5.37681159420289 1.02332140461487 53.0301285856465 0.033950444636297 75 2071 False False 0 0 0 0 0 0 0 6.14492753623188 1.22574646110428 59.4356755260654 0.00090497737556561 0.000363922793878801 0.00186370471782919 0.999831564763348 0.99939168785815 0.999979601060482 15 3) Uncertain significance No change no 1 +Streptomycin gid p.Leu91fs gid_p.Leu91fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1626 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1343 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Leu91Ile gid_p.Leu91Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Leu91Pro gid_p.Leu91Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 5 1 16 1 10352 15607 0.0015432098765432 0.000882326976774945 0.00250486960174422 0.999935930292158 0.99964307871082 0.999998377896754 0.941176470588235 0.713110603332779 0.998511825608733 0.833333333333333 0.358765421002325 0.99578925548551 0.833333333333333 0.358765421002325 0.99578925548551 7.53815687789799 0.843247259491794 355.931256410937 0.0404300970258868 95 2512 False False 24.1221020092735 3.74642669325099 1006.86346543863 0.000482765279521096 0.000156770559980102 0.00112625047428708 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 4 1 15 1 7721 11873 0.00193898655635987 0.00108562946918638 0.00319605008438842 0.999915782381674 0.999530859783396 0.999997867796783 0.9375 0.697679261565468 0.998418888277234 0.8 0.28358206388191 0.994949236620532 0.8 0.28358206388191 0.994949236620532 6.15101670768035 0.608496265031749 302.478125880143 0.0825986393070458 99 2071 False False 0 0 0 0 0 0 0 23.0663126538013 3.54672145861623 966.72074138712 0.000517799352750809 0.000141100342530739 0.00132523648537063 0.999915782381674 0.999530859783396 0.999997867796783 4 3) Uncertain significance No change no 1 +Streptomycin gid p.Leu91Val gid_p.Leu91Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 6 3 10362 15605 0.000578703703703703 0.000212402724453782 0.00125916554902567 0.999807790876473 0.99943838714673 0.999960360103688 0.666666666666666 0.29929505620854 0.925145368580308 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1584 2512 False False 3.01196680177571 0.64305389468782 18.6152161733465 0 0 0.000355937358633142 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 0 1 6 1 7730 11873 0.00077559462254395 0.000284681048736677 0.00168737281383633 0.999915782381674 0.999530859783396 0.999997867796783 0.857142857142857 0.421276802956804 0.996389703138099 0 0 0.975 0 0 0.975 0 0 59.8525424193363 1 806.5 2071 False False 0 0 0 0 0 0 0 9.21578266494178 1.11767707530695 423.06722176879 0 0 0.000477102121347592 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance No change no 1 +Streptomycin gid p.Leu94Arg gid_p.Leu94Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 1 3 3 3 10365 15605 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999807790876473 0.99943838714673 0.999960360103688 0.5 0.118117248757025 0.881882751242974 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.501849171892587 0.00956337956089424 6.25134874862395 1 973.5 2512 False False 1.50554751567776 0.201606412693291 11.2464963121379 9.64692263168049e-05 2.44238636565143e-06 0.000537373619049235 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Streptomycin gid p.Leu94Pro gid_p.Leu94Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 3 1 4 1 10364 15607 0.000385802469135802 0.000105127872737001 0.000987510251175401 0.999935930292158 0.99964307871082 0.999998377896754 0.8 0.28358206388191 0.994949236620532 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 4.51765727518332 0.362660210372462 236.877411073635 0.308510436047603 274 2512 False False 6.02354303357776 0.595936886271208 296.214625622934 0.000289379762708594 5.96810402691469e-05 0.000845455262078775 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 3 1 3 1 7733 11873 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 0.999915782381674 0.999530859783396 0.999997867796783 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 4.60610371136686 0.369734697559289 241.512824517625 0.307287813162931 214 2071 False False 0 0 0 0 0 0 0 4.60610371136686 0.369734697559289 241.512824517625 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 0.999915782381674 0.999530859783396 0.999997867796783 4 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Leu95fs gid_p.Leu95fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 2 2 10366 15606 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999871860584315 0.999537193839207 0.999984481345552 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1627 2512 False False 1.50549874590005 0.10909391082996 20.7696540777406 0 0 0.000355800035063835 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 2 7734 11872 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999831564763348 0.99939168785815 0.999979601060482 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1344 2071 False False 0 0 0 0 0 0 0 1.53504008275148 0.111228967362952 21.1783159842378 0 0 0.000476855424503066 0.999831564763348 0.99939168785815 0.999979601060482 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Leu95Val gid_p.Leu95Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Lys144* gid_p.Lys144* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Lys147fs gid_p.Lys147fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Lys163Asn gid_p.Lys163Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 2 2 10366 15606 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999871860584315 0.999537193839207 0.999984481345552 0.5 0.067585986488543 0.932414013511457 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.752749372950029 0.0127632667350056 14.4620006025996 1 973.5 2512 False False 1.50549874590005 0.10909391082996 20.7696540777406 9.64599209028648e-05 2.44215077354346e-06 0.000537321795461189 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.767420814479638 0.0130114906060525 14.7444541307454 1 806.5 2071 False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 12 3) Uncertain significance No change no 1 +Streptomycin gid p.Lys163Gln gid_p.Lys163Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 0.5 0.012579117093425 0.987420882906574 0.333333333333333 0.00840375865961264 0.905700675949754 1.5053535256101 0.0191825093710452 118.067140430791 1 973.5 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 0.5 0.012579117093425 0.987420882906574 0.333333333333333 0.00840375865961264 0.905700675949754 1.53484162895927 0.0195502581384442 120.380023442175 1 806.5 2071 False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 7 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Lys163Glu gid_p.Lys163Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 0.5 0.012579117093425 0.987420882906574 0.333333333333333 0.00840375865961264 0.905700675949754 1.5053535256101 0.0191825093710452 118.067140430791 1 973.5 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 0.5 0.012579117093425 0.987420882906574 0.333333333333333 0.00840375865961264 0.905700675949754 1.53484162895927 0.0195502581384442 120.380023442175 1 806.5 2071 False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 5 3) Uncertain significance No change no 1 +Streptomycin gid p.Lys163* gid_p.Lys163* 1 stop_gained (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Met1? gid_p.Met1? 1 start_lost (see "Genomic_coordinates" sheet) 0 0 0 0 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1647 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 0 0 0.000355765720726338 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1360 2071 False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 0 0 0.000476793790149404 0.999831564763348 0.99939168785815 0.999979601060482 5 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Met104Arg gid_p.Met104Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 58.6634076928655 1 973.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 59.8138891519084 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance No change no 1 +Streptomycin gid p.Met104fs gid_p.Met104fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 1 1 6 1 10362 15607 0.000578703703703703 0.000212402724453782 0.00125916554902567 0.999935930292158 0.99964307871082 0.999998377896754 0.857142857142857 0.421276802956804 0.996389703138099 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.50617641381972 0.019192990251866 118.131617542624 1 973.5 2512 False False 9.03705848291835 1.09610816025756 414.873240547969 9.64971533339766e-05 2.44309341478262e-06 0.000537529149810079 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 5 1 7731 11873 0.000646328852119958 0.0002098934625097 0.00150766595359595 0.999915782381674 0.999530859783396 0.999997867796783 0.833333333333333 0.358765421002325 0.99578925548551 0 0 0.975 0 0 0.975 0 0 59.8448077697702 1 806.5 2071 False False 0 0 0 0 0 0 0 7.67882550769628 0.858951237970164 362.566724149337 0 0 0.000477040423209609 0.999915782381674 0.999530859783396 0.999997867796783 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Met104Lys gid_p.Met104Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 9 3) Uncertain significance No change no 1 +Streptomycin gid p.Met150Arg gid_p.Met150Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.282736080598822 Inf 0.159301643065502 181.5 2512 False False Inf 0.282736080598822 Inf 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 8 3) Uncertain significance No change no 1 +Streptomycin gid p.Met150Thr gid_p.Met150Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Met159Arg gid_p.Met159Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Met159fs gid_p.Met159fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Met159Thr gid_p.Met159Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1631 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Met178Arg gid_p.Met178Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 3 0 10365 15608 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 1 0.99976368249849 1 1 0.292401773821286 1 1 0.025 1 1 0.025 1 Inf 0.0386072452937345 Inf 0.399091399091399 297.5 2512 False False Inf 0.622129167636411 Inf 9.64692263168049e-05 2.44238636565143e-06 0.000537373619049235 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0393613144801391 Inf 0.394461726758121 237.5 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0.000129282482223658 3.27314370392442e-06 0.000720103058325324 1 0.999689379610589 1 3 3) Uncertain significance No change no 1 +Streptomycin gid p.Met178fs gid_p.Met178fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1632 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1345 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Met178Ile gid_p.Met178Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1653 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Met178Thr gid_p.Met178Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Met218Ile gid_p.Met218Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1604 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1320 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 6 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Met218Val gid_p.Met218Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 3 1 4 2 10364 15606 0.000385802469135802 0.000105127872737001 0.000987510251175401 0.999871860584315 0.999537193839207 0.999984481345552 0.666666666666666 0.222778095503512 0.956728131707258 0.75 0.194120449683243 0.99369053679029 0.6 0.146632799634673 0.947255049473683 4.51736781165573 0.362636970973508 236.862256445216 0.308514750676259 276.5 2512 False False 3.01157854110382 0.43150328206235 33.3041852472562 0.000289379762708594 5.96810402691469e-05 0.000845455262078775 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 3 0 4 1 7732 11873 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.999915782381674 0.999530859783396 0.999997867796783 0.8 0.28358206388191 0.994949236620532 1 0.292401773821286 1 0.75 0.194120449683243 0.99369053679029 Inf 0.634366863425217 Inf 0.0613732399317593 93.5 2071 False False 0 0 0 0 0 0 0 6.14226590791515 0.607630898004113 302.048561734113 0.000387847446670976 7.99906106240067e-05 0.00113303233742371 0.999915782381674 0.999530859783396 0.999997867796783 10 3) Uncertain significance No change no 1 +Streptomycin gid p.Phe100fs gid_p.Phe100fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Phe100Leu gid_p.Phe100Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Streptomycin gid p.Phe100Val gid_p.Phe100Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 4 3 10 3 10358 15605 0.000964506172839506 0.000462612020337809 0.00177304351401163 0.999807790876473 0.99943838714673 0.999960360103688 0.769230769230769 0.461868460765959 0.949618926508848 0.571428571428571 0.184051567640083 0.901011721557492 0.571428571428571 0.184051567640083 0.901011721557492 2.00875329857758 0.339754535809119 13.716994471102 0.447741136956318 422 2512 False False 5.02188324644397 1.2925693817223 28.3812187360808 0.00038602586373287 0.000105188751465768 0.000988081885694551 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 4 2 6 2 7730 11872 0.00077559462254395 0.000284681048736677 0.00168737281383633 0.999831564763348 0.99939168785815 0.999979601060482 0.75 0.349144205587175 0.968145973750055 0.666666666666666 0.222778095503512 0.956728131707258 0.666666666666666 0.222778095503512 0.956728131707258 3.07166882276843 0.440076594695978 33.9676259286845 0.220846215984059 169 2071 False False 0 0 0 0 0 0 0 4.60750323415265 0.82353764401184 46.6843305297194 0.000517196793379881 0.000140936124797366 0.00132369493958413 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Phe12Cys gid_p.Phe12Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Phe12Leu gid_p.Phe12Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1564 2512 False False Inf 0.282736080598822 Inf 0 0 0.000355800035063835 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1284 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Phe12Ser gid_p.Phe12Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1685 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Streptomycin gid p.Phe12Val gid_p.Phe12Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.282736080598822 Inf 0.159301643065502 181.5 2512 False False Inf 0.282736080598822 Inf 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.288279755767314 Inf 0.155612234482449 125.5 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 2 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Phe204Leu gid_p.Phe204Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 58.6540000158548 1 973.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 59.801132462225 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 2 3) Uncertain significance No change no 1 +Streptomycin gid p.Phe204Ser gid_p.Phe204Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Pro14_Gly42del gid_p.Pro14_Gly42del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Streptomycin gid p.Pro14fs gid_p.Pro14fs 1 frameshift (see "Genomic_coordinates" sheet) 1 4 3 1 4 2 10364 15606 0.000385802469135802 0.000105127872737001 0.000987510251175401 0.999871860584315 0.999537193839207 0.999984481345552 0.666666666666666 0.222778095503512 0.956728131707258 0.75 0.194120449683243 0.99369053679029 0.6 0.146632799634673 0.947255049473683 4.51736781165573 0.362636970973508 236.862256445216 0.308514750676259 276.5 2512 False False 3.01157854110382 0.43150328206235 33.3041852472562 0.000289379762708594 5.96810402691469e-05 0.000845455262078775 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0393529118200762 Inf 0.394512723749298 338.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 3 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Pro151Arg gid_p.Pro151Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1678 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1388 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Pro151fs gid_p.Pro151fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Pro151Leu gid_p.Pro151Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Pro151Ser gid_p.Pro151Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Pro155Ser gid_p.Pro155Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Pro198Ala gid_p.Pro198Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Pro198Arg gid_p.Pro198Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1682 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Streptomycin gid p.Pro198Leu gid_p.Pro198Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1669 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1379 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance No change no 1 +Streptomycin gid p.Pro199Ala gid_p.Pro199Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 6 10368 15602 0 0 0.000355731413006942 0.999615581752947 0.999163472525571 0.999858912630967 0 0 0.4592581264399 0 0 0.602364635616474 0 0 0.4592581264399 0 0 2.28015540755431 0.155678943446982 141.5 2512 False False 0 0 1.27838118563185 0 0 0.000355731413006942 0.999615581752947 0.999163472525571 0.999858912630967 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 59.7961004349848 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 3.71438150990605 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 5 3) Uncertain significance No change no 1 +Streptomycin gid p.Pro199Arg gid_p.Pro199Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Pro29fs gid_p.Pro29fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Pro29Leu gid_p.Pro29Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1556 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1279 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Pro38Ala gid_p.Pro38Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Pro38fs gid_p.Pro38fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1658 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1369 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Pro38His gid_p.Pro38His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Pro38Ser gid_p.Pro38Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Pro3Ser gid_p.Pro3Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Pro3Thr gid_p.Pro3Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Pro6Ala gid_p.Pro6Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 2 3) Uncertain significance No change no 1 +Streptomycin gid p.Pro6Arg gid_p.Pro6Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1600 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1317 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 2 3) Uncertain significance No change no 1 +Streptomycin gid p.Pro6Leu gid_p.Pro6Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 3 10367 15605 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999807790876473 0.99943838714673 0.999960360103688 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.01590723734217 0.520331087227479 541.5 2512 False False 0.501752355229735 0.00956153582768186 6.25014259670444 0 0 0.000355765720726338 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.17205443383047 0.522230766108178 361 2071 False False 0 0 0 0 0 0 0 0 0 3.71438150990605 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 1 3) Uncertain significance No change no 1 +Streptomycin gid p.Pro6Thr gid_p.Pro6Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Pro75Ala gid_p.Pro75Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0386035211949905 Inf 0.399114533205004 308.5 2512 False False Inf 0.282736080598822 Inf 9.64599209028648e-05 2.44215077354346e-06 0.000537321795461189 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 15 3) Uncertain significance No change no 1 +Streptomycin gid p.Pro75Arg gid_p.Pro75Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 7 2 11 2 10357 15606 0.00106095679012345 0.000529741017552837 0.00189754996565939 0.999871860584315 0.999537193839207 0.999984481345552 0.846153846153846 0.545528944323442 0.980793328017471 0.777777777777777 0.399906426283687 0.971855026522101 0.777777777777777 0.399906426283687 0.971855026522101 5.27382446654436 1.00382381207465 52.0180653276477 0.034875596188968 93 2512 False False 8.28743844742686 1.80795021215549 76.8691873952884 0.000675414897722887 0.000271593564679134 0.00139111453644122 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 7 2 9 2 7727 11872 0.00116339193381592 0.000532110502771461 0.00220732634615895 0.999831564763348 0.99939168785815 0.999979601060482 0.818181818181818 0.482244147639827 0.97716880170004 0.777777777777777 0.399906426283687 0.971855026522101 0.777777777777777 0.399906426283687 0.971855026522101 5.37750744143911 1.02345384449515 53.0369485570157 0.0339447225348224 74 2071 False False 0 0 0 0 0 0 0 6.91393813899314 1.43038623489484 65.8449988812258 0.000905094388414791 0.000363969858500493 0.00186394557768835 0.999831564763348 0.99939168785815 0.999979601060482 16 Assoc w R 3) Uncertain significance DOWN from AwR to Uncertain yes 2 +Streptomycin gid p.Pro75Leu gid_p.Pro75Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 5 3 9 3 10359 15605 0.000868055555555555 0.000397004661559041 0.00164719739830421 0.999807790876473 0.99943838714673 0.999960360103688 0.75 0.42814153812181 0.945139355472007 0.625 0.244863216366551 0.914766585862746 0.625 0.244863216366551 0.914766585862746 2.51069923094249 0.488324377314851 16.1707673809117 0.279500558111425 221 2512 False False 4.51925861569649 1.12742337387643 25.9566145270552 0.000482439212659204 0.00015666466266492 0.00112549003268285 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 2 3 6 3 7730 11871 0.00077559462254395 0.000284681048736677 0.00168737281383633 0.999747347145022 0.999261820436506 0.999947893876346 0.666666666666666 0.29929505620854 0.925145368580308 0.4 0.0527449505263169 0.853367200365326 0.4 0.0527449505263169 0.853367200365326 1.02380336351875 0.0854663639556547 8.9407164065303 1 806.5 2071 False False 0 0 0 0 0 0 0 3.07141009055627 0.655670534896531 18.98369017237 0.000258665287118468 3.13271014957261e-05 0.000934072314686065 0.999747347145022 0.999261820436506 0.999947893876346 13 3) Uncertain significance No change no 1 +Streptomycin gid p.Pro75Ser gid_p.Pro75Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 20 11 9 21 15 10347 15593 0.00202546296296296 0.00125421710937554 0.00309447762369452 0.999038954382368 0.998415396005541 0.999462013453075 0.583333333333333 0.407565240891776 0.744858951673532 0.55 0.315278133040548 0.769422103224075 0.423076923076923 0.233521983127443 0.630819619076033 1.84189727564618 0.693605263014357 5.0305013304797 0.177313774782779 206 2512 False False 2.10980960664927 1.0361651005883 4.40159191371072 0.00106198107742807 0.000530252560696326 0.00189938116321409 0.999038954382368 0.998415396005541 0.999462013453075 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 4 2 9 6 7727 11868 0.00116339193381592 0.000532110502771461 0.00220732634615895 0.999494694290045 0.998900489118281 0.999814539856352 0.6 0.322869766206281 0.836635676140486 0.666666666666666 0.222778095503512 0.956728131707258 0.4 0.121552258119827 0.737621923393055 3.07182606444933 0.440099067842687 33.9693611883542 0.220835688814172 168 2071 False False 0 0 0 0 0 0 0 2.303869548337 0.731961717821895 7.86875931699252 0.00051739749062217 0.000140990821553652 0.00132420838954471 0.999494694290045 0.998900489118281 0.999814539856352 40 3) Uncertain significance No change no 1 +Streptomycin gid p.Pro75Thr gid_p.Pro75Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 3 8 10365 15600 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999487442337262 0.998990308225149 0.99977868883794 0.272727272727272 0.0602177341729066 0.609742559572421 0 0 0.409616397225003 0 0 0.369416647552819 0 0 1.04450563899838 0.0468725498718463 103 2512 False False 0.564399421128798 0.0964092202317815 2.35228955636283 0 0 0.000355834356021348 0.999487442337262 0.998990308225149 0.99977868883794 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 3 8 7733 11866 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 0.999326259053394 0.998672895689377 0.999709083033384 0.272727272727272 0.0602177341729066 0.609742559572421 0 0 0.409616397225003 0 0 0.369416647552819 0 0 1.06500079760899 0.0472750709261281 86 2071 False False 0 0 0 0 0 0 0 0.575423509634036 0.0982822102159668 2.39848288727533 0 0 0.000476917074793532 0.999326259053394 0.998672895689377 0.999709083033384 2 3) Uncertain significance No change no 1 +Streptomycin gid p.Pro78Arg gid_p.Pro78Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 1 4 10367 15604 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999743721168631 0.999343955596995 0.999930168370675 0.2 0.00505076337946806 0.716417936118089 0.333333333333333 0.00840375865961264 0.905700675949754 0.2 0.00505076337946806 0.716417936118089 0.752580302884151 0.0127604015381483 14.4587528579642 1 610 2512 False False 0.376290151442075 0.00764455959995544 3.80334957923739 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0393529118200762 Inf 0.394512723749298 338.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 5 3) Uncertain significance No change no 1 +Streptomycin gid p.Pro78Gln gid_p.Pro78Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Pro78Leu gid_p.Pro78Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 20 4 16 5 16 10363 15592 0.000482253086419753 0.000156604214122162 0.00112505595550109 0.998974884674526 0.998335809333792 0.999413948080433 0.238095238095238 0.0821758755930225 0.471659827654621 0.2 0.0573339970500327 0.436614002996668 0.2 0.0573339970500327 0.436614002996668 0.376145903695841 0.091467523438025 1.16650227629186 0.107238595495692 133 2512 False False 0.470182379619801 0.134672146760727 1.34378677426843 0.000385839683611459 0.000105138014297713 0.000987605477659245 0.998974884674526 0.998335809333792 0.999413948080433 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 12 3) Uncertain significance No change no 1 +Streptomycin gid p.Pro84_Arg137del gid_p.Pro84_Arg137del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Streptomycin gid p.Pro84fs gid_p.Pro84fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1601 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1318 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Pro84Leu gid_p.Pro84Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 81 48 33 56 36 10312 15572 0.00540123456790123 0.00408253757689058 0.00700829228576838 0.997693490517683 0.99680823466253 0.998384042270265 0.608695652173913 0.501368680251614 0.708821829128803 0.592592592592592 0.477697865320156 0.700510113269394 0.571428571428571 0.458750969400895 0.678921085691591 2.19648776359404 1.38005843302009 3.53451351959913 0.000563659425294075 44 2512 True False 2.34902163606585 1.51707526460667 3.67878449296632 0.00463320463320463 0.0034180763011076 0.00613831717148919 0.997693490517683 0.99680823466253 0.998384042270265 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance 1 5 1 4 1 6 7735 11868 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999494694290045 0.998900489118281 0.999814539856352 0.142857142857142 0.00361029686190058 0.578723197043195 0.2 0.00505076337946806 0.716417936118089 0.142857142857142 0.00361029686190058 0.578723197043195 0.383581124757595 0.0077923279480832 3.87732070240803 0.654463678829613 490 2071 False False 0 0 0 0 0 0 0 0.255720749838396 0.00556297279916227 2.10858771426871 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999494694290045 0.998900489118281 0.999814539856352 52 Assoc w RI Evidence from ALL dataset only 2) Assoc w R - Interim No change yes ALL only 1 +Streptomycin gid p.Pro84Ser gid_p.Pro84Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Pro84Thr gid_p.Pro84Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 2 3) Uncertain significance No change no 1 +Streptomycin gid p.Pro93Arg gid_p.Pro93Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Pro93fs gid_p.Pro93fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 3 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Pro93Gln gid_p.Pro93Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 1 3 1 4 10367 15604 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999743721168631 0.999343955596995 0.999930168370675 0.2 0.00505076337946806 0.716417936118089 0.25 0.00630946320970987 0.805879550316756 0.2 0.00505076337946806 0.716417936118089 0.501720201922767 0.00956092345641947 6.24974209876977 1 973.5 2512 False False 0.376290151442075 0.00764455959995544 3.80334957923739 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Pro93Leu gid_p.Pro93Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 2 6 9 8 10359 15600 0.000868055555555555 0.000397004661559041 0.00164719739830421 0.999487442337262 0.998990308225149 0.99977868883794 0.529411764705882 0.278118300331106 0.770167312734009 0.25 0.0318540262499442 0.650855794412824 0.2 0.0252107263268333 0.556095462307641 0.501978955497634 0.0495421425340846 2.80803146357495 0.489542793749437 425 2512 False False 1.69417897480451 0.579980535139982 5.04867373331826 0.000193031560660167 2.33778724645479e-05 0.000697120579030196 0.999487442337262 0.998990308225149 0.99977868883794 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 2 6 7 8 7729 11866 0.000904860392967942 0.000363875741427306 0.00186346392020999 0.999326259053394 0.998672895689377 0.999709083033384 0.466666666666666 0.212666729519307 0.734138652722603 0.25 0.0318540262499442 0.650855794412824 0.2 0.0252107263268333 0.556095462307641 0.51175227498167 0.0505040488369177 2.8629453672444 0.492254230581938 349 2071 False False 0 0 0 0 0 0 0 1.34334972182688 0.414519645876375 4.2412753896386 0.000258698745311085 3.1331153835274e-05 0.000934193095527727 0.999326259053394 0.998672895689377 0.999709083033384 19 3) Uncertain significance No change no 1 +Streptomycin gid p.Pro93Ser gid_p.Pro93Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 4 10367 15604 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999743721168631 0.999343955596995 0.999930168370675 0.2 0.00505076337946806 0.716417936118089 0 0 0.841886116991581 0 0 0.602364635616474 0 0 8.01539361065742 0.520324886423033 452.5 2512 False False 0.376290151442075 0.00764455959995544 3.80334957923739 0 0 0.000355765720726338 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 4 7735 11870 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999663129526697 0.999137704464366 0.999908206750254 0.2 0.00505076337946806 0.716417936118089 0 0 0.841886116991581 0 0 0.602364635616474 0 0 8.17242258163327 0.522235304327817 368.5 2071 False False 0 0 0 0 0 0 0 0.383645765998707 0.00779364023519555 3.87797408017955 0 0 0.000476793790149404 0.999663129526697 0.999137704464366 0.999908206750254 3 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Ser122fs gid_p.Ser122fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Ser122Pro gid_p.Ser122Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01642086402598 0.520337288498982 548 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 0 0 0.000355765720726338 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 59.8138891519084 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Ser131Arg gid_p.Ser131Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 2 3) Uncertain significance No change no 1 +Streptomycin gid p.Ser131Thr gid_p.Ser131Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 58.6540000158548 1 973.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance No change no 1 +Streptomycin gid p.Ser136Ala gid_p.Ser136Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1553 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1277 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Ser136fs gid_p.Ser136fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 58.6540000158548 1 973.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 5 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Ser136Leu gid_p.Ser136Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1639 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1351 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Ser136Pro gid_p.Ser136Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 2 5 10366 15603 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999679651460789 0.999252573060182 0.999895975781355 0.285714285714285 0.0366925661760855 0.709579136262657 0 0 0.602364635616474 0 0 0.521823750104981 0 0 2.28074179725928 0.155716747995536 164.5 2512 False False 0.602083735288443 0.0572994001432256 3.67859568857157 0 0 0.000355800035063835 0.999679651460789 0.999252573060182 0.999895975781355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 7736 11870 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.71406862449918 0.283346149162266 180.5 2071 False False 0 0 0 0 0 0 0 0 0 2.32513012450998 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 8 3) Uncertain significance No change no 1 +Streptomycin gid p.Ser136* gid_p.Ser136* 1 stop_gained (see "Genomic_coordinates" sheet) 1 17 12 5 23 11 10345 15597 0.00221836419753086 0.00140675621922997 0.00332678737658432 0.999295233213736 0.998739328260189 0.999648132128855 0.676470588235294 0.494734699101495 0.826116572506078 0.705882352941176 0.440417281245662 0.89686448562968 0.521739130434782 0.305878001491373 0.731803813824446 3.61844369260512 1.18612383820168 13.1181793132136 0.0124625793225257 72 2512 False False 3.15243200492113 1.47549120376997 7.16680805362188 0.00115863667085063 0.00059882325345934 0.00202302950013906 0.999295233213736 0.998739328260189 0.999648132128855 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 16 11 5 21 11 7715 11863 0.00271458117890382 0.00168112962543325 0.00414654804366048 0.999073606198416 0.998343031567643 0.999537459717592 0.65625 0.468068963719731 0.814280908283433 0.6875 0.413379363548641 0.889830045282882 0.5 0.282210520938092 0.717789479061907 3.38283862605314 1.08297110918231 12.4195799445146 0.0207124626275181 66 2071 False False 0 0 0 0 0 0 0 2.93552112178165 1.3520744636771 6.74563349969308 0.00142376391405643 0.000710945324380863 0.00254607562049257 0.999073606198416 0.998343031567643 0.999537459717592 4 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Ser149Arg gid_p.Ser149Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 29 18 11 26 15 10342 15593 0.00250771604938271 0.00163875720960142 0.00367224120631176 0.999038954382368 0.998415396005541 0.999462013453075 0.634146341463414 0.469362548032833 0.778772137938934 0.620689655172413 0.422604640664401 0.793131300513492 0.545454545454545 0.363506531014846 0.718933805706183 2.46720345985478 1.10296105078333 5.7829949218904 0.0212219454536334 79 2512 False False 2.61340810932766 1.33281191161657 5.3095184371659 0.00173745173745173 0.00103003890554873 0.0027445381160531 0.999038954382368 0.998415396005541 0.999462013453075 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 22 14 8 19 10 7717 11864 0.00245604963805584 0.00147932993205813 0.00383278019133476 0.999157823816742 0.998451755191613 0.9995960722577 0.655172413793103 0.456694272332056 0.820616350764888 0.636363636363636 0.406576668825646 0.828020562353667 0.583333333333333 0.366430645656362 0.778903094653321 2.69042373979525 1.05268047641463 7.40537571821598 0.0273972324779909 71 2071 False False 0 0 0 0 0 0 0 2.92103148892056 1.2913704507643 7.03673391374814 0.00181089121717759 0.000990373629141785 0.00303650297120213 0.999157823816742 0.998451755191613 0.9995960722577 56 3) Uncertain significance No change no 1 +Streptomycin gid p.Ser149Asn gid_p.Ser149Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 10365 15608 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 1 0.99976368249849 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1568 2512 False False Inf 0.622129167636411 Inf 0 0 0.000355834356021348 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 7733 11874 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 1 0.999689379610589 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1289 2071 False False 0 0 0 0 0 0 0 Inf 0.634338273987677 Inf 0 0 0.000476917074793532 1 0.999689379610589 1 1 3) Uncertain significance No change no 1 +Streptomycin gid p.Ser149Cys gid_p.Ser149Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1596 2512 False False Inf 0.282736080598822 Inf 0 0 0.000355800035063835 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Ser149fs gid_p.Ser149fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.50544998553101 0.0191837380556942 118.074698097101 1 973.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Ser149Thr gid_p.Ser149Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Ser181Leu gid_p.Ser181Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01642086402598 0.520337288498982 548 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 0 0 0.000355765720726338 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1361 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Ser181* gid_p.Ser181* 1 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1670 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1380 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Ser181Trp gid_p.Ser181Trp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1679 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1389 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Ser220Arg gid_p.Ser220Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Ser220fs gid_p.Ser220fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1671 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1381 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Ser2Cys gid_p.Ser2Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Ser70Arg gid_p.Ser70Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 29 17 12 23 14 10345 15594 0.00221836419753086 0.00140675621922997 0.00332678737658432 0.99910302409021 0.99849548434986 0.999509530910458 0.621621621621621 0.447568022450812 0.775423856419568 0.586206896551724 0.389362791396906 0.764759790247101 0.548387096774193 0.360342327160816 0.726835013996264 2.13547607539874 0.960690016882714 4.90293785416539 0.0558634979196847 106 2512 False False 2.47643444037837 1.22056393864937 5.20679463360373 0.00164060992086469 0.000955997078673097 0.00262548012304614 0.99910302409021 0.99849548434986 0.999509530910458 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 18 13 5 18 7 7718 11867 0.00232678386763185 0.0013795644494434 0.00367483823172597 0.999410476671719 0.998785736251934 0.999762949244471 0.72 0.506123178193744 0.879283311495933 0.722222222222222 0.465198034416943 0.90305078747444 0.65 0.407811465467171 0.846090795215458 3.99769370303187 1.33669996215126 14.3276880614725 0.00648681639051466 49 2071 False False 0 0 0 0 0 0 0 3.95376300299855 1.57466759221002 11.2041157207709 0.00168154184452205 0.000895644457830375 0.00287377119086043 0.999410476671719 0.998785736251934 0.999762949244471 76 3) Uncertain significance No change no 1 +Streptomycin gid p.Ser70Asn gid_p.Ser70Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 12 11 1 17 3 10351 15605 0.00163966049382716 0.0009554436768022 0.00262396149717064 0.999807790876473 0.99943838714673 0.999960360103688 0.85 0.621073173454686 0.967929062814536 0.916666666666666 0.615203834849055 0.997892406768139 0.785714285714285 0.492024322951528 0.953420712110132 16.5834218916046 2.40943147320677 711.471580470714 0.000309922377774916 40 2512 True False 8.54297491385695 2.47007112982959 45.5703360287344 0.00106157112526539 0.000530047824931801 0.00189864826023626 0.999807790876473 0.99943838714673 0.999960360103688 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 11 11 0 17 1 7719 11873 0.00219751809720785 0.00128064014327926 0.00351611538908953 0.999915782381674 0.999530859783396 0.999997867796783 0.944444444444444 0.727056400326631 0.99859444383263 1 0.715085847081845 1 0.916666666666666 0.615203834849055 0.997892406768139 Inf 3.85883657600843 Inf 3.56905913983171e-05 29 2071 True False 0 0 0 0 0 0 0 26.14859437751 4.0950591018127 1087.30336554113 0.00142302716688227 0.000710577328084509 0.00254475885717009 0.999915782381674 0.999530859783396 0.999997867796783 6 1) Assoc w R UP from Uncertain to AwR yes 4 +Streptomycin gid p.Ser70Gly gid_p.Ser70Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 2 1 3 1 10365 15607 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999935930292158 0.99964307871082 0.999998377896754 0.75 0.194120449683243 0.99369053679029 0.666666666666666 0.0942993240502461 0.991596241340387 0.666666666666666 0.0942993240502461 0.991596241340387 3.01148094548962 0.156744547276127 177.49143307316 0.567660882162454 568 2512 False False 4.51722141823444 0.362625225225282 236.854590713406 0.000192919841805729 2.33643418036207e-05 0.000696717215522511 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 59.8138891519084 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 6 3) Uncertain significance No change no 1 +Streptomycin gid p.Ser70Ile gid_p.Ser70Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 4 2 10364 15606 0.000385802469135802 0.000105127872737001 0.000987510251175401 0.999871860584315 0.999537193839207 0.999984481345552 0.666666666666666 0.222778095503512 0.956728131707258 0.5 0.012579117093425 0.987420882906574 0.333333333333333 0.00840375865961264 0.905700675949754 1.50578927055191 0.0191880592619257 118.101283331121 1 973.5 2512 False False 3.01157854110382 0.43150328206235 33.3041852472562 9.64785335262904e-05 2.44262200321851e-06 0.000537425452634802 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 4 2 7732 11872 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.999831564763348 0.99939168785815 0.999979601060482 0.666666666666666 0.222778095503512 0.956728131707258 0.5 0.012579117093425 0.987420882906574 0.333333333333333 0.00840375865961264 0.905700675949754 1.53543714433523 0.0195578427502557 120.426684243042 1 806.5 2071 False False 0 0 0 0 0 0 0 3.07087428867046 0.439962791152193 33.9588674822466 0.000129315918789603 3.27399024170944e-06 0.000720289244853199 0.999831564763348 0.99939168785815 0.999979601060482 1 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Ser9_Ala25del gid_p.Ser9_Ala25del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Streptomycin gid p.Ser9Pro gid_p.Ser9Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1666 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1377 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 1 3) Uncertain significance No change no 1 +Streptomycin gid p.Ter225Cysext*? gid_p.Ter225Cysext*? 1 stop_lost (see "Genomic_coordinates" sheet) 1 6 1 5 1 11 10367 15597 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999295233213736 0.998739328260189 0.999648132128855 0.0833333333333333 0.00210759323186022 0.384796165150944 0.166666666666666 0.00421074451448947 0.641234578997674 0.0833333333333333 0.00210759323186022 0.384796165150944 0.300897077264396 0.00636552229681376 2.68965790794439 0.41256014532921 416 2512 False False 0.136771398756543 0.00318142307571837 0.941307040788776 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999295233213736 0.998739328260189 0.999648132128855 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 1 3 1 9 7735 11865 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999242041435068 0.998561648359028 0.999653356368186 0.1 0.00252857854446178 0.445016117028195 0.25 0.00630946320970987 0.805879550316756 0.1 0.00252857854446178 0.445016117028195 0.51131221719457 0.00974329275108726 6.36960057363702 1 806.5 2071 False False 0 0 0 0 0 0 0 0.170437405731523 0.00389218880341809 1.23047590677427 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999242041435068 0.998561648359028 0.999653356368186 11 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Thr106fs gid_p.Thr106fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0385973247056878 Inf 0.399153031761308 409.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0393529118200762 Inf 0.394512723749298 338.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Thr146Ala gid_p.Thr146Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 5 3) Uncertain significance No change no 1 +Streptomycin gid p.Thr146Arg gid_p.Thr146Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Thr146Lys gid_p.Thr146Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 5 2 6 2 10362 15606 0.000578703703703703 0.000212402724453782 0.00125916554902567 0.999871860584315 0.999537193839207 0.999984481345552 0.75 0.349144205587175 0.968145973750055 0.714285714285714 0.290420863737342 0.963307433823914 0.714285714285714 0.290420863737342 0.963307433823914 3.76519976838448 0.616246546468429 39.5454492649786 0.123640832151782 135 2512 False False 4.51823972206137 0.807646031204088 45.7789383259808 0.000482299604514324 0.000156619321884204 0.00112516444340334 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 3 0 3 0 7733 11874 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 1 0.999689379610589 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.634338273987677 Inf 0.0613782650697297 96 2071 False False 0 0 0 0 0 0 0 Inf 0.634338273987677 Inf 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 1 0.999689379610589 1 7 3) Uncertain significance No change no 1 +Streptomycin gid p.Thr146Met gid_p.Thr146Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 58.6502452744631 1 973.5 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 59.801132462225 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 1 3) Uncertain significance No change no 1 +Streptomycin gid p.Thr146Pro gid_p.Thr146Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1613 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1329 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Thr190Ala gid_p.Thr190Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Thr190Ile gid_p.Thr190Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 58.6596525903968 1 973.5 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 0 0 0.000355765720726338 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1314 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance No change no 1 +Streptomycin gid p.Thr190Pro gid_p.Thr190Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Thr201fs gid_p.Thr201fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.50544998553101 0.0191837380556942 118.074698097101 1 973.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.53497091144149 0.0195519049186736 120.390152361053 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Thr201Pro gid_p.Thr201Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 58.6634076928655 1 973.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 5 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Thr98fs gid_p.Thr98fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1644 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Thr98Ile gid_p.Thr98Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 3 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Thr98Pro gid_p.Thr98Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 2 10366 15606 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999871860584315 0.999537193839207 0.999984481345552 0.5 0.067585986488543 0.932414013511457 1 0.025 1 0.333333333333333 0.00840375865961264 0.905700675949754 Inf 0.0385985745000087 Inf 0.399145266238016 406 2512 False False 1.50549874590005 0.10909391082996 20.7696540777406 9.64599209028648e-05 2.44215077354346e-06 0.000537321795461189 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 2 7734 11872 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999831564763348 0.99939168785815 0.999979601060482 0.5 0.067585986488543 0.932414013511457 1 0.025 1 0.333333333333333 0.00840375865961264 0.905700675949754 Inf 0.0393546845675247 Inf 0.394501963584434 332.5 2071 False False 0 0 0 0 0 0 0 1.53504008275148 0.111228967362952 21.1783159842378 0.000129282482223658 3.27314370392442e-06 0.000720103058325324 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Trp123Cys gid_p.Trp123Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01642086402598 0.520337288498982 548 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 0 0 0.000355765720726338 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17379939830658 0.52225229054203 453 2071 False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 0 0 0.000476793790149404 0.999831564763348 0.99939168785815 0.999979601060482 1 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Trp123* gid_p.Trp123* 1 stop_gained (see "Genomic_coordinates" sheet) 1 2 1 1 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 0.5 0.012579117093425 0.987420882906574 0.333333333333333 0.00840375865961264 0.905700675949754 1.5053535256101 0.0191825093710452 118.067140430791 1 973.5 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 4 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Trp148Arg gid_p.Trp148Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1633 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Streptomycin gid p.Trp148Cys gid_p.Trp148Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01642086402598 0.520337288498982 548 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 0 0 0.000355765720726338 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17379939830658 0.52225229054203 453 2071 False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 0 0 0.000476793790149404 0.999831564763348 0.99939168785815 0.999979601060482 1 3) Uncertain significance No change no 1 +Streptomycin gid p.Trp148fs gid_p.Trp148fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.282736080598822 Inf 0.159301643065502 181.5 2512 False False Inf 0.282736080598822 Inf 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.288279755767314 Inf 0.155612234482449 125.5 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Trp148Leu gid_p.Trp148Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 2 10366 15606 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999871860584315 0.999537193839207 0.999984481345552 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 58.6653062545381 1 973.5 2512 False False 1.50549874590005 0.10909391082996 20.7696540777406 0 0 0.000355800035063835 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1362 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Trp148* gid_p.Trp148* 1 stop_gained (see "Genomic_coordinates" sheet) 1 4 3 1 8 5 10360 15603 0.000771604938271604 0.00033318123262376 0.00151980017311994 0.999679651460789 0.999252573060182 0.999895975781355 0.615384615384615 0.315777602914063 0.861420661109839 0.75 0.194120449683243 0.99369053679029 0.375 0.0852334141372535 0.755136783633448 4.51824324324324 0.362707225004092 236.908094637122 0.308501700046083 273 2512 False False 2.40972972972972 0.694822005291174 9.3658001588517 0.000289491460001929 5.97040780066728e-05 0.000845781507372653 0.999679651460789 0.999252573060182 0.999895975781355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 2 1 7 5 7729 11869 0.000904860392967942 0.000363875741427306 0.00186346392020999 0.999578911908371 0.999017596768841 0.999863260157969 0.583333333333333 0.276669685682105 0.848347770191569 0.666666666666666 0.0942993240502461 0.991596241340387 0.285714285714285 0.0366925661760855 0.709579136262657 3.07128994695303 0.159849117742019 181.015736074644 0.566036139637862 473 2071 False False 0 0 0 0 0 0 0 2.14990296286712 0.58708742343859 8.5937734640548 0.000258698745311085 3.1331153835274e-05 0.000934193095527727 0.999578911908371 0.999017596768841 0.999863260157969 10 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Trp45Arg gid_p.Trp45Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 5 0 11 2 10357 15606 0.00106095679012345 0.000529741017552837 0.00189754996565939 0.999871860584315 0.999537193839207 0.999984481345552 0.846153846153846 0.545528944323442 0.980793328017471 1 0.478176249895018 1 0.714285714285714 0.290420863737342 0.963307433823914 Inf 1.38042119244215 Inf 0.0101105200843788 68 2512 False False 8.28743844742686 1.80795021215549 76.8691873952884 0.000482532329666087 0.000156694904439332 0.00112570719690705 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 5 0 11 0 7725 11874 0.0014219234746639 0.000710026047388019 0.00254278626393864 1 0.999689379610589 1 1 0.715085847081845 1 1 0.478176249895018 1 1 0.478176249895018 1 Inf 1.408031914551 Inf 0.00952431196339726 56 2071 False False 0 0 0 0 0 0 0 Inf 3.85616586380724 Inf 0.000646830530401035 0.000210056406162775 0.00150883569400416 1 0.999689379610589 1 22 3) Uncertain significance No change no 1 +Streptomycin gid p.Trp45Cys gid_p.Trp45Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Trp45Gly gid_p.Trp45Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Trp45Ser gid_p.Trp45Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 3 1 3 1 10365 15607 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999935930292158 0.99964307871082 0.999998377896754 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 4.51722141823444 0.362625225225282 236.854590713406 0.308516935797272 279.5 2512 False False 4.51722141823444 0.362625225225282 236.854590713406 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Streptomycin gid p.Trp45* gid_p.Trp45* 1 stop_gained (see "Genomic_coordinates" sheet) 1 17 10 7 11 8 10357 15600 0.00106095679012345 0.000529741017552837 0.00189754996565939 0.999487442337262 0.998990308225149 0.99977868883794 0.578947368421052 0.334997844011735 0.797478561022837 0.588235294117647 0.329247153946757 0.815563038216053 0.555555555555555 0.307571658998756 0.7846984926127 2.15175381729403 0.739073910342153 6.66341139751379 0.137659264208321 137 2512 False False 2.0710630491455 0.758471894609075 5.93311870986087 0.000964599209028648 0.00046265665291099 0.00177321447241818 0.999487442337262 0.998990308225149 0.99977868883794 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 5 6 6 7 7730 11867 0.00077559462254395 0.000284681048736677 0.00168737281383633 0.999410476671719 0.998785736251934 0.999762949244471 0.461538461538461 0.192232441801288 0.748654517729696 0.454545454545454 0.167488094063707 0.766206402340654 0.416666666666666 0.15165222980843 0.723330314317894 1.27932298404484 0.308767541157081 5.03304636256737 0.761424746584402 503 2071 False False 0 0 0 0 0 0 0 1.31587506930327 0.36522174782293 4.5745349791727 0.000646412411118293 0.000209920602227715 0.00150786078436255 0.999410476671719 0.998785736251934 0.999762949244471 4 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Tyr195Cys gid_p.Tyr195Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1585 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Tyr195His gid_p.Tyr195His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 149 220 10219 15388 0.0143711419753086 0.0121692169832468 0.0168516425146154 0.98590466427473 0.983929931464149 0.987695103426081 0.403794037940379 0.353325771222375 0.455818740582796 NA NA NA 0 0 0.0166278395399936 NA NA NA NA NA NA False True 1.01985250291346 0.821471360199432 1.26328731968812 0 0 0.000360917283871902 0.98590466427473 0.983929931464149 0.987695103426081 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 117 152 7619 11722 0.015124095139607 0.0125236649638654 0.0180985533245312 0.987198922014485 0.98501100116006 0.989142878002929 0.434944237918215 0.374850741875147 0.496487026711431 NA NA NA 0 0 0.0239768209037916 NA NA NA NA NA NA False True 0 1 1 0 0 1 0 1.18425715489669 0.920884819101341 1.51986227827524 0 0 0.000484051263773271 0.987198922014485 0.98501100116006 0.989142878002929 840 Not assoc w R 5) Not assoc w R No change yes 1 +Streptomycin gid p.Tyr195Phe gid_p.Tyr195Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 1 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Tyr195* gid_p.Tyr195* 1 stop_gained (see "Genomic_coordinates" sheet) 1 3 1 2 2 2 10366 15606 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999871860584315 0.999537193839207 0.999984481345552 0.5 0.067585986488543 0.932414013511457 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.752749372950029 0.0127632667350056 14.4620006025996 1 973.5 2512 False False 1.50549874590005 0.10909391082996 20.7696540777406 9.64599209028648e-05 2.44215077354346e-06 0.000537321795461189 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17379939830658 0.52225229054203 453 2071 False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 0 0 0.000476793790149404 0.999831564763348 0.99939168785815 0.999979601060482 14 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Tyr22Asn gid_p.Tyr22Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1620 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Tyr22Cys gid_p.Tyr22Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 2 1 10366 15607 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999935930292158 0.99964307871082 0.999998377896754 0.666666666666666 0.0942993240502461 0.991596241340387 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.50559521512637 0.0191855877809429 118.086077597882 1 610 2512 False False 3.01119043025274 0.156729426968348 177.474331043773 9.64599209028648e-05 2.44215077354346e-06 0.000537321795461189 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.53497091144149 0.0195519049186736 120.390152361053 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 3 3) Uncertain significance No change no 1 +Streptomycin gid p.Tyr22His gid_p.Tyr22His 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 1 3 1 5 10367 15603 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999679651460789 0.999252573060182 0.999895975781355 0.166666666666666 0.00421074451448947 0.641234578997674 0.25 0.00630946320970987 0.805879550316756 0.166666666666666 0.00421074451448947 0.641234578997674 0.5016880486158 0.00956031108516074 6.24934160084306 1 610 2512 False False 0.30101282916948 0.00636796908209055 2.69069235774657 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999679651460789 0.999252573060182 0.999895975781355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 4 7736 11870 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 8.17136611448302 0.522222275631291 353.5 2071 False False 0 0 0 0 0 0 0 0 0 2.32513012450998 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 4 3) Uncertain significance No change no 1 +Streptomycin gid p.Tyr22Ser gid_p.Tyr22Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 3 1 10365 15607 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999935930292158 0.99964307871082 0.999998377896754 0.75 0.194120449683243 0.99369053679029 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.50574047274481 0.0191874378630812 118.097459292191 1 973.5 2512 False False 4.51722141823444 0.362625225225282 236.854590713406 9.64692263168049e-05 2.44238636565143e-06 0.000537373619049235 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Streptomycin gid p.Tyr22* gid_p.Tyr22* 1 stop_gained (see "Genomic_coordinates" sheet) 1 5 2 3 2 3 10366 15605 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999807790876473 0.99943838714673 0.999960360103688 0.4 0.0527449505263169 0.853367200365326 0.4 0.0527449505263169 0.853367200365326 0.4 0.0527449505263169 0.853367200365326 1.00360151778249 0.0837840645585397 8.76371184924575 1 973.5 2512 False False 1.00360151778249 0.0837840645585397 8.76371184924575 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 1 3 1 3 7735 11871 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999747347145022 0.999261820436506 0.999947893876346 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.511570782159017 0.0097482170621519 6.37282132403124 1 806.5 2071 False False 0 0 0 0 0 0 0 0.511570782159017 0.0097482170621519 6.37282132403124 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999747347145022 0.999261820436506 0.999947893876346 10 Assoc w RI Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Val105fs gid_p.Val105fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Val105Glu gid_p.Val105Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 20 18 2 21 2 10347 15606 0.00202546296296296 0.00125421710937554 0.00309447762369452 0.999871860584315 0.999537193839207 0.999984481345552 0.913043478260869 0.719620664090589 0.989290033962124 0.9 0.683017285980917 0.987651472829705 0.9 0.683017285980917 0.987651472829705 13.5743693824296 3.2482540309879 120.785524490104 4.81087448507285e-06 28 2512 True False 15.8367642795013 3.86955126483841 139.271053515562 0.00173661360347322 0.00102954187040516 0.00274321483867908 0.999871860584315 0.999537193839207 0.999984481345552 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 19 17 2 20 2 7716 11872 0.00258531540847983 0.00157987085455139 0.00398999964984359 0.999831564763348 0.99939168785815 0.999979601060482 0.909090909090909 0.708387258446066 0.988794413975849 0.894736842105263 0.668623335543234 0.986987835628222 0.894736842105263 0.668623335543234 0.986987835628222 13.0782789009849 3.10275345077937 116.834368146268 9.02987598038235e-06 21 2071 True False 0 0 0 0 0 0 0 15.386210471747 3.73546582057269 136.083811191487 0.00219837061942325 0.00128113716085313 0.00351747855617389 0.999831564763348 0.99939168785815 0.999979601060482 8 1) Assoc w R UP from Uncertain to AwR yes 4 +Streptomycin gid p.Val105Gly gid_p.Val105Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Val110Ala gid_p.Val110Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 3 0 3 0 10365 15608 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 1 0.99976368249849 1 1 0.292401773821286 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.622129167636411 Inf 0.06357591560857 116 2512 False False Inf 0.622129167636411 Inf 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Val110fs gid_p.Val110fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1569 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 15 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Val112Gly gid_p.Val112Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 3 10367 15605 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999807790876473 0.99943838714673 0.999960360103688 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.01590723734217 0.520331087227479 541.5 2512 False False 0.501752355229735 0.00956153582768186 6.25014259670444 0 0 0.000355765720726338 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17379939830658 0.52225229054203 453 2071 False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 0 0 0.000476793790149404 0.999831564763348 0.99939168785815 0.999979601060482 9 3) Uncertain significance No change no 1 +Streptomycin gid p.Val115Ala gid_p.Val115Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 4 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Val115fs gid_p.Val115fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1602 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Val115Gly gid_p.Val115Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 2 3 3 3 10365 15605 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999807790876473 0.99943838714673 0.999960360103688 0.5 0.118117248757025 0.881882751242974 0.4 0.0527449505263169 0.853367200365326 0.4 0.0527449505263169 0.853367200365326 1.00369834378517 0.0837921488991071 8.76455780167155 1 610 2512 False False 1.50554751567776 0.201606412693291 11.2464963121379 0.000192919841805729 2.33643418036207e-05 0.000696717215522511 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 1 3 2 3 7734 11871 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999747347145022 0.999261820436506 0.999947893876346 0.4 0.0527449505263169 0.853367200365326 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.511636927851047 0.00974947663174677 6.37364544566016 1 806.5 2071 False False 0 0 0 0 0 0 0 1.02327385570209 0.0854221600622099 8.93608975066686 0.000129282482223658 3.27314370392442e-06 0.000720103058325324 0.999747347145022 0.999261820436506 0.999947893876346 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Val124Ala gid_p.Val124Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 9 3 10359 15605 0.000868055555555555 0.000397004661559041 0.00164719739830421 0.999807790876473 0.99943838714673 0.999960360103688 0.75 0.42814153812181 0.945139355472007 0.5 0.012579117093425 0.987420882906574 0.25 0.00630946320970987 0.805879550316756 1.50641953856549 0.0191960865894332 118.150668574543 1 610 2512 False False 4.51925861569649 1.12742337387643 25.9566145270552 9.65250965250965e-05 2.44380087340122e-06 0.000537684770626777 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 2 1 7734 11873 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999915782381674 0.999530859783396 0.999997867796783 0.666666666666666 0.0942993240502461 0.991596241340387 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.53516938194983 0.0195544326818075 120.405703250322 1 512 2071 False False 0 0 0 0 0 0 0 3.07033876389966 0.159799628612092 180.959738606129 0.000129282482223658 3.27314370392442e-06 0.000720103058325324 0.999915782381674 0.999530859783396 0.999997867796783 5 3) Uncertain significance No change no 1 +Streptomycin gid p.Val124fs gid_p.Val124fs 1 frameshift (see "Genomic_coordinates" sheet) 1 6 4 2 5 3 10363 15605 0.000482253086419753 0.000156604214122162 0.00112505595550109 0.999807790876473 0.99943838714673 0.999960360103688 0.625 0.244863216366551 0.914766585862746 0.666666666666666 0.222778095503512 0.956728131707258 0.571428571428571 0.184051567640083 0.901011721557492 3.01167615555341 0.431517258851534 33.3052605652638 0.225018095489127 213 2512 False False 2.50973012962784 0.48813575589439 16.1645252811411 0.000385839683611459 0.000105138014297713 0.000987605477659245 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17379939830658 0.52225229054203 453 2071 False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 0 0 0.000476793790149404 0.999831564763348 0.99939168785815 0.999979601060482 3 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Val124Gly gid_p.Val124Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 11 5 6 6 6 10362 15602 0.000578703703703703 0.000212402724453782 0.00125916554902567 0.999615581752947 0.999163472525571 0.999858912630967 0.5 0.210944638239296 0.789055361760703 0.454545454545454 0.167488094063707 0.766206402340654 0.454545454545454 0.167488094063707 0.766206402340654 1.25474490124171 0.302818892366728 4.93592238533747 0.763119162854808 596 2512 False False 1.50569388149005 0.402402545484648 5.63315572905451 0.000482299604514324 0.000156619321884204 0.00112516444340334 0.999615581752947 0.999163472525571 0.999858912630967 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 5 5 6 5 7730 11869 0.00077559462254395 0.000284681048736677 0.00168737281383633 0.999578911908371 0.999017596768841 0.999863260157969 0.545454545454545 0.233793597659345 0.832511905936292 0.5 0.187086028447398 0.812913971552601 0.5 0.187086028447398 0.812913971552601 1.53544631306597 0.353239117333294 6.67452215469313 0.529362794154202 468 2071 False False 0 0 0 0 0 0 0 1.84253557567917 0.468317960236373 7.63455249382227 0.000646412411118293 0.000209920602227715 0.00150786078436255 0.999578911908371 0.999017596768841 0.999863260157969 12 3) Uncertain significance No change no 1 +Streptomycin gid p.Val124Leu gid_p.Val124Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Val124Met gid_p.Val124Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Val135fs gid_p.Val135fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 11 0 10357 15608 0.00106095679012345 0.000529741017552837 0.00189754996565939 1 0.99976368249849 1 1 0.715085847081845 1 NA NA NA NA NA NA NA NA NA NA 1680 2512 False False Inf 3.78113295637047 Inf 0 0 0.000356109162232076 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 11 0 7725 11874 0.0014219234746639 0.000710026047388019 0.00254278626393864 1 0.999689379610589 1 1 0.715085847081845 1 NA NA NA NA NA NA NA NA NA NA 1390 2071 False False 0 0 0 0 0 0 0 Inf 3.85616586380724 Inf 0 0 0.000477410851584718 1 0.999689379610589 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Val135Gly gid_p.Val135Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 3 3 6 3 10362 15605 0.000578703703703703 0.000212402724453782 0.00125916554902567 0.999807790876473 0.99943838714673 0.999960360103688 0.666666666666666 0.29929505620854 0.925145368580308 0.5 0.118117248757025 0.881882751242974 0.5 0.118117248757025 0.881882751242974 1.50598340088785 0.201664774305183 11.2497512796773 0.688449701499978 590 2512 False False 3.01196680177571 0.64305389468782 18.6152161733465 0.000289435600578871 5.96925569151148e-05 0.000845618353258805 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 3 3 6 3 7730 11871 0.00077559462254395 0.000284681048736677 0.00168737281383633 0.999747347145022 0.999261820436506 0.999947893876346 0.666666666666666 0.29929505620854 0.925145368580308 0.5 0.118117248757025 0.881882751242974 0.5 0.118117248757025 0.881882751242974 1.53570504527813 0.205630473799541 11.4723434202882 0.686118869946182 497 2071 False False 0 0 0 0 0 0 0 3.07141009055627 0.655670534896531 18.98369017237 0.000387947756368809 8.00113005907662e-05 0.00113332526638003 0.999747347145022 0.999261820436506 0.999947893876346 4 3) Uncertain significance No change no 1 +Streptomycin gid p.Val135Met gid_p.Val135Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 10368 15603 0 0 0.000355731413006942 0.999679651460789 0.999252573060182 0.999895975781355 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.64266120859479 0.164659119890409 198.5 2512 False False 0 0 1.64266120859479 0 0 0.000355731413006942 0.999679651460789 0.999252573060182 0.999895975781355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 7736 11870 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.32513012450998 0.158605093840654 142 2071 False False 0 0 0 0 0 0 0 0 0 2.32513012450998 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 16 3) Uncertain significance No change no 1 +Streptomycin gid p.Val139Ala gid_p.Val139Ala 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Streptomycin gid p.Val139Met gid_p.Val139Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 58.6634076928655 1 973.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 59.8138891519084 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Val171Gly gid_p.Val171Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.50544998553101 0.0191837380556942 118.074698097101 1 973.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 4 3) Uncertain significance No change no 1 +Streptomycin gid p.Val171Leu gid_p.Val171Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Val177Leu gid_p.Val177Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 58.6540000158548 1 973.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 59.801132462225 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 2 3) Uncertain significance No change no 1 +Streptomycin gid p.Val177Met gid_p.Val177Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Val184fs gid_p.Val184fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.282736080598822 Inf 0.159301643065502 181.5 2512 False False Inf 0.282736080598822 Inf 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.288279755767314 Inf 0.155612234482449 125.5 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Val186Phe gid_p.Val186Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1588 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1308 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Val188Ala gid_p.Val188Ala 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 3) Uncertain significance No change no 1 +Streptomycin gid p.Val188fs gid_p.Val188fs 1 frameshift (see "Genomic_coordinates" sheet) 1 5 3 2 3 2 10365 15606 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999871860584315 0.999537193839207 0.999984481345552 0.6 0.146632799634673 0.947255049473683 0.6 0.146632799634673 0.947255049473683 0.6 0.146632799634673 0.947255049473683 2.25846599131693 0.258657968313028 27.0476864113414 0.394237929959746 288 2512 False False 2.25846599131693 0.258657968313028 27.0476864113414 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Val188Gly gid_p.Val188Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 2 3) Uncertain significance No change no 1 +Streptomycin gid p.Val189fs gid_p.Val189fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0386035211949905 Inf 0.399114533205004 308.5 2512 False False Inf 0.282736080598822 Inf 9.64599209028648e-05 2.44215077354346e-06 0.000537321795461189 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0393613144801391 Inf 0.394461726758121 237.5 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0.000129282482223658 3.27314370392442e-06 0.000720103058325324 1 0.999689379610589 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Val202Ala gid_p.Val202Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 2 2 10366 15606 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999871860584315 0.999537193839207 0.999984481345552 0.5 0.067585986488543 0.932414013511457 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01719423016258 0.52034662480125 555 2512 False False 1.50549874590005 0.10909391082996 20.7696540777406 0 0 0.000355800035063835 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 3) Uncertain significance No change no 1 +Streptomycin gid p.Val202fs gid_p.Val202fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1634 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Val202Gly gid_p.Val202Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 3 1 10365 15607 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999935930292158 0.99964307871082 0.999998377896754 0.75 0.194120449683243 0.99369053679029 1 0.158113883008419 1 0.666666666666666 0.0942993240502461 0.991596241340387 Inf 0.282745237798141 Inf 0.159295442743639 172 2512 False False 4.51722141823444 0.362625225225282 236.854590713406 0.000192919841805729 2.33643418036207e-05 0.000696717215522511 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1356 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance No change no 1 +Streptomycin gid p.Val202Leu gid_p.Val202Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 58.6540000158548 1 973.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1357 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Val203Glu gid_p.Val203Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1575 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1295 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Val203Gly gid_p.Val203Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.6429945931141 0.280491932584249 243 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.71438150990605 0.283358886007265 193.5 2071 False False 0 0 0 0 0 0 0 0 0 3.71438150990605 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 2 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Val203Leu gid_p.Val203Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0385973247056878 Inf 0.399153031761308 409.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0393529118200762 Inf 0.394512723749298 338.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 4 3) Uncertain significance No change no 1 +Streptomycin gid p.Val203Met gid_p.Val203Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 2 2 2 2 10366 15606 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999871860584315 0.999537193839207 0.999984481345552 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 1.50549874590005 0.10909391082996 20.7696540777406 0.653642588225642 583.5 2512 False False 1.50549874590005 0.10909391082996 20.7696540777406 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 2 2 2 2 7734 11872 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999831564763348 0.99939168785815 0.999979601060482 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 0.5 0.067585986488543 0.932414013511457 1.53504008275148 0.111228967362952 21.1783159842378 0.649667550655831 485 2071 False False 0 0 0 0 0 0 0 1.53504008275148 0.111228967362952 21.1783159842378 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Val36Ala gid_p.Val36Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 3 10366 15605 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999807790876473 0.99943838714673 0.999960360103688 0.4 0.0527449505263169 0.853367200365326 0 0 0.975 0 0 0.707598226178713 0 0 58.6615507900406 1 973.5 2512 False False 1.00360151778249 0.0837840645585397 8.76371184924575 0 0 0.000355800035063835 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 59.8088564761233 1 806.5 2071 False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 0 0 0.000476793790149404 0.999831564763348 0.99939168785815 0.999979601060482 14 3) Uncertain significance No change no 1 +Streptomycin gid p.Val36fs gid_p.Val36fs 1 frameshift (see "Genomic_coordinates" sheet) 1 6 1 5 1 5 10367 15603 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999679651460789 0.999252573060182 0.999895975781355 0.166666666666666 0.00421074451448947 0.641234578997674 0.166666666666666 0.00421074451448947 0.641234578997674 0.166666666666666 0.00421074451448947 0.641234578997674 0.30101282916948 0.00636796908209055 2.69069235774657 0.412577015188174 417.5 2512 False False 0.30101282916948 0.00636796908209055 2.69069235774657 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999679651460789 0.999252573060182 0.999895975781355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 1 4 1 4 7735 11870 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999663129526697 0.999137704464366 0.999908206750254 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 0.2 0.00505076337946806 0.716417936118089 0.383645765998707 0.00779364023519555 3.87797408017955 0.654465279037393 494 2071 False False 0 0 0 0 0 0 0 0.383645765998707 0.00779364023519555 3.87797408017955 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999663129526697 0.999137704464366 0.999908206750254 3 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Val36Gly gid_p.Val36Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 3 3 8 4 10360 15604 0.000771604938271604 0.00033318123262376 0.00151980017311994 0.999743721168631 0.999343955596995 0.999930168370675 0.666666666666666 0.348875506418814 0.900753908850416 0.5 0.118117248757025 0.881882751242974 0.428571428571428 0.0989882784425078 0.815948432359917 1.5061776061776 0.201690774157057 11.2512016333645 0.688433857999329 589 2512 False False 3.01235521235521 0.806734748419887 13.6706140578425 0.000289491460001929 5.97040780066728e-05 0.000845781507372653 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 2 2 7 3 7729 11871 0.000904860392967942 0.000363875741427306 0.00186346392020999 0.999747347145022 0.999261820436506 0.999947893876346 0.7 0.347547149940002 0.933260488822265 0.5 0.067585986488543 0.932414013511457 0.4 0.0527449505263169 0.853367200365326 1.53590373916418 0.111291546008183 21.1902392521604 0.649553700841661 481 2071 False False 0 0 0 0 0 0 0 3.5837753913831 0.81778515516938 21.4815595723006 0.000258698745311085 3.1331153835274e-05 0.000934193095527727 0.999747347145022 0.999261820436506 0.999947893876346 2 3) Uncertain significance No change no 1 +Streptomycin gid p.Val41Ala gid_p.Val41Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1608 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Val41fs gid_p.Val41fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1686 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Val41Gly gid_p.Val41Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1579 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1299 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance No change no 1 +Streptomycin gid p.Val41Ile gid_p.Val41Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 2 2 10366 15606 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999871860584315 0.999537193839207 0.999984481345552 0.5 0.067585986488543 0.932414013511457 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.752749372950029 0.0127632667350056 14.4620006025996 1 973.5 2512 False False 1.50549874590005 0.10909391082996 20.7696540777406 9.64599209028648e-05 2.44215077354346e-06 0.000537321795461189 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.53497091144149 0.0195519049186736 120.390152361053 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 6 3) Uncertain significance No change no 1 +Streptomycin gid p.Val41Leu gid_p.Val41Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance No change no 1 +Streptomycin gid p.Val54fs gid_p.Val54fs 1 frameshift (see "Genomic_coordinates" sheet) 1 21 7 14 30 15 10338 15593 0.00289351851851851 0.00195307029853899 0.00412812175097628 0.999038954382368 0.998415396005541 0.999462013453075 0.666666666666666 0.510496362141638 0.799994311989305 0.333333333333333 0.145876942343096 0.569675482904124 0.318181818181818 0.138646521553797 0.54872442757377 0.754159411878506 0.257517964046023 1.9975129752416 0.658171578615514 588 2512 False False 3.01663764751402 1.57202135596813 6.03567545339975 0.000676655389076848 0.000272092460046525 0.00139366859077176 0.999038954382368 0.998415396005541 0.999462013453075 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 12 4 8 21 8 7715 11866 0.00271458117890382 0.00168112962543325 0.00414654804366048 0.999326259053394 0.998672895689377 0.999709083033384 0.724137931034482 0.527615517569966 0.872659885897769 0.333333333333333 0.0992460911495833 0.651124493581186 0.333333333333333 0.0992460911495833 0.651124493581186 0.769021386908619 0.169406402412824 2.87194983219365 0.774248468452152 505 2071 False False 0 0 0 0 0 0 0 4.03736228127025 1.71669401905763 10.5471620949739 0.00051820183961653 0.000141210033790817 0.00132626617883359 0.999326259053394 0.998672895689377 0.999709083033384 127 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Val65Ala gid_p.Val65Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 23 14 9 26 12 10342 15596 0.00250771604938271 0.00163875720960142 0.00367224120631176 0.999231163505894 0.998657382918185 0.999602669866138 0.684210526315789 0.513472945593978 0.824974661098873 0.608695652173913 0.385418957388849 0.802923576030985 0.538461538461538 0.333708218475292 0.734128782577048 2.34581748640924 0.945315522866736 6.14613924719546 0.0534391373130102 105 2512 False False 3.26738864178431 1.59062338530269 7.11017600258554 0.00135187331015836 0.000739272586471411 0.00226717446716575 0.999231163505894 0.998657382918185 0.999602669866138 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 20 14 6 26 9 7710 11865 0.00336091003102378 0.0021965968588793 0.0049206608623853 0.999242041435068 0.998561648359028 0.999653356368186 0.742857142857142 0.567441150305961 0.875106028083238 0.7 0.45721081772371 0.881068409594272 0.608695652173913 0.385418957388849 0.802923576030985 3.59079118028534 1.29550059354329 11.4016444918514 0.0096925575031578 58 2071 False False 0 0 0 0 0 0 0 4.44574146130566 2.01728758155369 10.7895373411068 0.0018125323666494 0.000991271482212146 0.00303925315961698 0.999242041435068 0.998561648359028 0.999653356368186 15 3) Uncertain significance No change no 1 +Streptomycin gid p.Val65fs gid_p.Val65fs 1 frameshift (see "Genomic_coordinates" sheet) 1 4 1 3 4 4 10364 15604 0.000385802469135802 0.000105127872737001 0.000987510251175401 0.999743721168631 0.999343955596995 0.999930168370675 0.5 0.157012770487058 0.842987229512941 0.25 0.00630946320970987 0.805879550316756 0.2 0.00505076337946806 0.716417936118089 0.501865431622282 0.00956368914581298 6.2515513852831 1 973.5 2512 False False 1.50559629486684 0.280357681374081 8.08594018183047 9.64785335262904e-05 2.44262200321851e-06 0.000537425452634802 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 4 3 7732 11871 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.999747347145022 0.999261820436506 0.999947893876346 0.571428571428571 0.184051567640083 0.901011721557492 0.333333333333333 0.00840375865961264 0.905700675949754 0.25 0.00630946320970987 0.805879550316756 0.767653905845835 0.0130154401539142 14.7489324647304 1 806.5 2071 False False 0 0 0 0 0 0 0 2.04707708225556 0.346205885559351 13.9794751519065 0.000129315918789603 3.27399024170944e-06 0.000720289244853199 0.999747347145022 0.999261820436506 0.999947893876346 1 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Val65Gly gid_p.Val65Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 15 8 7 11 11 10357 15597 0.00106095679012345 0.000529741017552837 0.00189754996565939 0.999295233213736 0.998739328260189 0.999648132128855 0.5 0.282210520938092 0.717789479061907 0.533333333333333 0.265861347277396 0.787333270480692 0.421052631578947 0.202521438977162 0.665002155988264 1.72107201478641 0.545185753093675 5.57677786751432 0.302536336992963 271 2512 False False 1.5059380129381 0.591812338750014 3.83179789502504 0.000771828268210323 0.000333277683638013 0.00152023989262574 0.999295233213736 0.998739328260189 0.999648132128855 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 13 8 5 10 9 7726 11865 0.00129265770423991 0.000620048157733657 0.00237595446225449 0.999242041435068 0.998561648359028 0.999653356368186 0.526315789473684 0.288643247916998 0.755525310533804 0.615384615384615 0.315777602914063 0.861420661109839 0.470588235294117 0.22983268726599 0.721881699668893 2.45715764949521 0.708412083025519 9.55127590450774 0.153124136064816 116 2071 False False 0 0 0 0 0 0 0 1.70635947881611 0.622821194169231 4.7477574861545 0.00103439358675976 0.000446680156528578 0.00203714489989349 0.999242041435068 0.998561648359028 0.999653356368186 22 3) Uncertain significance No change no 1 +Streptomycin gid p.Val65Ile gid_p.Val65Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1570 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1290 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Val65Phe gid_p.Val65Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 1 4 2 6 10366 15602 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999615581752947 0.999163472525571 0.999858912630967 0.25 0.0318540262499442 0.650855794412824 0.2 0.00505076337946806 0.716417936118089 0.142857142857142 0.00361029686190058 0.578723197043195 0.376278217248697 0.00764431724580241 3.80322903668031 0.654369338694231 586 2512 False False 0.50170428966493 0.0495150381555913 2.80649490654312 9.64599209028648e-05 2.44215077354346e-06 0.000537321795461189 0.999615581752947 0.999163472525571 0.999858912630967 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 1 4 2 6 7734 11868 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999494694290045 0.998900489118281 0.999814539856352 0.25 0.0318540262499442 0.650855794412824 0.2 0.00505076337946806 0.716417936118089 0.142857142857142 0.00361029686190058 0.578723197043195 0.383630721489526 0.00779333468756898 3.87782215607753 0.654464900121561 491 2071 False False 0 0 0 0 0 0 0 0.511507628652702 0.0504799102640932 2.8615766008904 0.000129282482223658 3.27314370392442e-06 0.000720103058325324 0.999494694290045 0.998900489118281 0.999814539856352 18 3) Uncertain significance No change no 1 +Streptomycin gid p.Val66Ala gid_p.Val66Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1597 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Streptomycin gid p.Val66fs gid_p.Val66fs 1 frameshift (see "Genomic_coordinates" sheet) 1 3 1 2 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.752676762805054 0.0127620362920002 14.460605698152 1 1332 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Val66Met gid_p.Val66Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Val77Ala gid_p.Val77Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 11 8 3 19 5 10349 15603 0.00183256172839506 0.00110367119743855 0.00286029933187508 0.999679651460789 0.999252573060182 0.999895975781355 0.791666666666666 0.578487156362747 0.928681382801945 0.727272727272727 0.390257440427578 0.939782265827093 0.615384615384615 0.315777602914063 0.861420661109839 4.02048507102135 0.964638071819062 23.5327886799298 0.0324464799891818 91 2512 False False 5.72919122620543 2.06817868149453 19.6364619116821 0.000772424447233755 0.000333535159560259 0.00152141372289123 0.999679651460789 0.999252573060182 0.999895975781355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 5 2 16 4 7720 11870 0.00206825232678386 0.00118263260320744 0.00335654494667737 0.999663129526697 0.999137704464366 0.999908206750254 0.8 0.563385997003331 0.942666002949967 0.714285714285714 0.290420863737342 0.963307433823914 0.555555555555555 0.212008506778868 0.863004337734833 3.84391191709844 0.629070587580822 40.3814343712584 0.120631385919256 114 2071 False False 0 0 0 0 0 0 0 6.15025906735751 1.98283893160091 25.2872563522898 0.000647249190938511 0.000210192385922864 0.00150981186511978 0.999663129526697 0.999137704464366 0.999908206750254 11 3) Uncertain significance No change no 1 +Streptomycin gid p.Val77fs gid_p.Val77fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 1 0 2 1 10366 15607 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999935930292158 0.99964307871082 0.999998377896754 0.666666666666666 0.0942993240502461 0.991596241340387 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0386010478475006 Inf 0.399129899129899 318 2512 False False 3.01119043025274 0.156729426968348 177.474331043773 9.64599209028648e-05 2.44215077354346e-06 0.000537321795461189 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0393613144801391 Inf 0.394461726758121 237.5 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0.000129282482223658 3.27314370392442e-06 0.000720103058325324 1 0.999689379610589 1 NA Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Val77Gly gid_p.Val77Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 59 24 35 26 38 10342 15570 0.00250771604938271 0.00163875720960142 0.00367224120631176 0.997565351101999 0.996659770234853 0.998276539121395 0.40625 0.28514701281086 0.536323122292284 0.406779661016949 0.280696201162427 0.542548107617117 0.387096774193548 0.266008508628901 0.519347404380213 1.0323507472995 0.587149679635759 1.78683563839496 0.894998538593971 600 2512 False False 1.03008682022208 0.600133338630585 1.74262907775791 0.00231526143160331 0.001483977577579 0.0034429793522176 0.997565351101999 0.996659770234853 0.998276539121395 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 3 3 3 3 7733 11871 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 0.999747347145022 0.999261820436506 0.999947893876346 0.5 0.118117248757025 0.881882751242974 0.5 0.118117248757025 0.881882751242974 0.5 0.118117248757025 0.881882751242974 1.53510927195137 0.205550714955708 11.4678941037862 0.686163529261889 498 2071 False False 0 0 0 0 0 0 0 1.53510927195137 0.205550714955708 11.4678941037862 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 0.999747347145022 0.999261820436506 0.999947893876346 48 3) Uncertain significance No change no 1 +Streptomycin gid p.Val88Ala gid_p.Val88Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 5 4 6 4 10362 15604 0.000578703703703703 0.000212402724453782 0.00125916554902567 0.999743721168631 0.999343955596995 0.999930168370675 0.6 0.262378076606945 0.878447741880172 0.555555555555555 0.212008506778868 0.863004337734833 0.555555555555555 0.212008506778868 0.863004337734833 1.8823586180274 0.405015239247936 9.48867531179504 0.498100252227113 427 2512 False False 2.25883034163288 0.535491434983611 10.8863434801125 0.000482299604514324 0.000156619321884204 0.00112516444340334 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 5 4 6 4 7730 11870 0.00077559462254395 0.000284681048736677 0.00168737281383633 0.999663129526697 0.999137704464366 0.999908206750254 0.6 0.262378076606945 0.878447741880172 0.555555555555555 0.212008506778868 0.863004337734833 0.555555555555555 0.212008506778868 0.863004337734833 1.91946959896507 0.4129756980141 9.67647934298611 0.330132771065293 217 2071 False False 0 0 0 0 0 0 0 2.30336351875808 0.545992298099125 11.1018843698377 0.000646412411118293 0.000209920602227715 0.00150786078436255 0.999663129526697 0.999137704464366 0.999908206750254 4 3) Uncertain significance No change no 1 +Streptomycin gid p.Val88fs gid_p.Val88fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 2 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.282736080598822 Inf 0.159301643065502 181.5 2512 False False Inf 0.282736080598822 Inf 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.288279755767314 Inf 0.155612234482449 125.5 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 2 Indel frameshift or premature stop codon (LoF) 2) Assoc w R - Interim No change no 1 +Streptomycin gid p.Val88Gly gid_p.Val88Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 1 10366 15607 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999935930292158 0.99964307871082 0.999998377896754 0.666666666666666 0.0942993240502461 0.991596241340387 1 0.158113883008419 1 0.666666666666666 0.0942993240502461 0.991596241340387 Inf 0.28271796523282 Inf 0.159313909304284 189 2512 False False 3.01119043025274 0.156729426968348 177.474331043773 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 1 7734 11873 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999915782381674 0.999530859783396 0.999997867796783 0.666666666666666 0.0942993240502461 0.991596241340387 1 0.158113883008419 1 0.666666666666666 0.0942993240502461 0.991596241340387 Inf 0.288255476599014 Inf 0.155628106803387 131.5 2071 False False 0 0 0 0 0 0 0 3.07033876389966 0.159799628612092 180.959738606129 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance No change no 1 +Streptomycin gid p.Val89_Arg102delinsGly gid_p.Val89_Arg102delinsGly 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 NA 3) Uncertain significance DOWN from AwRI to Uncertain yes 2 +Streptomycin gid p.Val89Ala gid_p.Val89Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin gid p.Val89Gly gid_p.Val89Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK c.1011G>A glpK_c.1011G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.102C>T glpK_c.102C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.1050C>T glpK_c.1050C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 5 0 10363 15608 0.000482253086419753 0.000156604214122162 0.00112505595550109 1 0.99976368249849 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.37979907306709 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 5 0 7731 11874 0.000646328852119958 0.0002098934625097 0.00150766595359595 1 0.999689379610589 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.40693962335604 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.1062C>T glpK_c.1062C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.1102C>T glpK_c.1102C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 21 10368 15587 0 0 0.000355731413006942 0.998654536135315 0.997944046996364 0.999166949785744 0 0 0.161097615219079 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.28879663094906 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 12 7736 11862 0 0 0.000476732171726368 0.998989388580091 0.998235331388827 0.999477696754876 0 0 0.264648469397051 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.552062026148079 NA NA NA NA NA NA 28 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.1104G>A glpK_c.1104G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.1107C>T glpK_c.1107C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.1122G>A glpK_c.1122G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.1134C>T glpK_c.1134C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 429 1253 9939 14355 0.0413773148148148 0.0376248211963383 0.0453900726356506 0.919720656073808 0.915347045088543 0.923937071706732 0.255053507728894 0.234367093448737 0.276598007914024 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.494500491305021 0.440809674370474 0.553961438859702 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 235 944 7501 10930 0.030377456049638 0.0266661840957717 0.0344478694461625 0.920498568300488 0.915486930402635 0.925302893795352 0.199321458863443 0.176866658714464 0.223286715424123 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.362741182531594 0.312142305331211 0.420243306669504 NA NA NA NA NA NA 4151 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.1137C>T glpK_c.1137C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.1161C>T glpK_c.1161C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.1164C>T glpK_c.1164C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.1179G>A glpK_c.1179G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.117G>C glpK_c.117G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.50544998553101 0.0191837380556942 118.074698097101 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.-11G>T glpK_c.-11G>T 2 upstream_gene_variant 4139766 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2401 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK c.1209C>T glpK_c.1209C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.120C>T glpK_c.120C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.1215C>T glpK_c.1215C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.17274275317631 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.123C>A glpK_c.123C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 9 10367 15599 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.99942337262942 0.998905665124108 0.999736296428239 0.1 0.00252857854446178 0.445016117028195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.167186478462643 0.00381816513248207 1.20692977805764 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 6 7735 11868 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999494694290045 0.998900489118281 0.999814539856352 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.255720749838396 0.00556297279916227 2.10858771426871 NA NA NA NA NA NA 32 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.1245C>T glpK_c.1245C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.1257C>G glpK_c.1257C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 0 10364 15608 0.000385802469135802 0.000105127872737001 0.000987510251175401 1 0.99976368249849 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.993868422549659 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.1257C>T glpK_c.1257C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.1260G>A glpK_c.1260G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.50544998553101 0.0191837380556942 118.074698097101 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.1269G>A glpK_c.1269G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 8 10368 15600 0 0 0.000355731413006942 0.999487442337262 0.998990308225149 0.99977868883794 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.881730950187969 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 8 7736 11866 0 0 0.000476732171726368 0.999326259053394 0.998672895689377 0.999709083033384 0 0 0.369416647552819 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.898935416250629 NA NA NA NA NA NA 20 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.1293C>T glpK_c.1293C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.1299C>T glpK_c.1299C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.-12C>G glpK_c.-12C>G 2 upstream_gene_variant 4139767 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK c.1305T>C glpK_c.1305T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.1329G>A glpK_c.1329G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.752676762805054 0.0127620362920002 14.460605698152 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.1341G>T glpK_c.1341G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 16 10368 15592 0 0 0.000355731413006942 0.998974884674526 0.998335809333792 0.999413948080433 0 0 0.205907214207822 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.390047640252407 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 9 7736 11865 0 0 0.000476732171726368 0.999242041435068 0.998561648359028 0.999653356368186 0 0 0.336267116879942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.777323095649869 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.1356C>A glpK_c.1356C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.17274275317631 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.-13A>G glpK_c.-13A>G 2 upstream_gene_variant 4139768 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK c.1401G>A glpK_c.1401G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.17274275317631 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.1422G>A glpK_c.1422G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.1428T>C glpK_c.1428T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.1446A>C glpK_c.1446A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 11 0 10357 15608 0.00106095679012345 0.000529741017552837 0.00189754996565939 1 0.99976368249849 1 1 0.715085847081845 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 3.78113295637047 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 11 0 7725 11874 0.0014219234746639 0.000710026047388019 0.00254278626393864 1 0.999689379610589 1 1 0.715085847081845 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 3.85616586380724 Inf NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.1464A>G glpK_c.1464A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.1491C>G glpK_c.1491C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.1527G>A glpK_c.1527G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.282736080598822 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.1542T>A glpK_c.1542T>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.1542T>C glpK_c.1542T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.50544998553101 0.0191837380556942 118.074698097101 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.1545C>T glpK_c.1545C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.1551C>A glpK_c.1551C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.1551C>T glpK_c.1551C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 11 5 10357 15603 0.00106095679012345 0.000529741017552837 0.00189754996565939 0.999679651460789 0.999252573060182 0.999895975781355 0.6875 0.413379363548641 0.889830045282882 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.31433812880177 1.06117952068985 12.1676597783544 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 10 4 7726 11870 0.00129265770423991 0.000620048157733657 0.00237595446225449 0.999663129526697 0.999137704464366 0.999908206750254 0.714285714285714 0.418964742816338 0.916110681692872 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.84092674087496 1.10725979503529 16.7765671286618 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.159C>T glpK_c.159C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.17274275317631 NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.189C>T glpK_c.189C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.-18C>T glpK_c.-18C>T 2 upstream_gene_variant 4139773 NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2363 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1953 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK c.-19T>C glpK_c.-19T>C 2 upstream_gene_variant 4139774 NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2263 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK c.-19T>G glpK_c.-19T>G 2 upstream_gene_variant 4139774 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK c.201C>A glpK_c.201C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.-21_-20insC glpK_c.-21_-20insC 2 upstream_gene_variant 4139775 NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2291 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK c.219G>A glpK_c.219G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.234C>T glpK_c.234C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.238C>T glpK_c.238C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.246G>A glpK_c.246G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 7 10367 15601 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999551512045105 0.999076163117038 0.999819666176692 0.125 0.0031597235312519 0.526509670875206 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.214981603715084 0.00477381113707295 1.6738454938462 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 7 7735 11867 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999410476671719 0.998785736251934 0.999762949244471 0.125 0.0031597235312519 0.526509670875206 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.219170745221165 0.0048665806440923 1.70661149583256 NA NA NA NA NA NA 16 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.264G>A glpK_c.264G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.267G>A glpK_c.267G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.267G>T glpK_c.267G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.50544998553101 0.0191837380556942 118.074698097101 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.27A>G glpK_c.27A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 7 10366 15601 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999551512045105 0.999076163117038 0.999819666176692 0.222222222222222 0.0281449734778982 0.600093573716312 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.430004685648135 0.0435795940165012 2.25913666217328 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 6 7735 11868 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999494694290045 0.998900489118281 0.999814539856352 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.255720749838396 0.00556297279916227 2.10858771426871 NA NA NA NA NA NA 15 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.288G>A glpK_c.288G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.17274275317631 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.306G>A glpK_c.306G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.309C>T glpK_c.309C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.315A>G glpK_c.315A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.336T>C glpK_c.336T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.50544998553101 0.0191837380556942 118.074698097101 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.-34C>T glpK_c.-34C>T 2 upstream_gene_variant 4139789 NA 0 0 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2275 2512 False False Inf 0.282736080598822 Inf 0 0 0.000355800035063835 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1893 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0 0 0.000476855424503066 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK c.360C>T glpK_c.360C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.363C>G glpK_c.363C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 10368 15604 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.28044779470556 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 7736 11870 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.32513012450998 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.363C>T glpK_c.363C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.-37delC glpK_c.-37delC 2 upstream_gene_variant 4139791 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2336 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1934 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK c.-38C>T glpK_c.-38C>T 2 upstream_gene_variant 4139793 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK c.39C>G glpK_c.39C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.408C>G glpK_c.408C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.411C>T glpK_c.411C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.414G>A glpK_c.414G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.417G>A glpK_c.417G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 3 10367 15605 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999807790876473 0.99943838714673 0.999960360103688 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.501752355229735 0.00956153582768186 6.25014259670444 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 22 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.435T>A glpK_c.435T>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.50544998553101 0.0191837380556942 118.074698097101 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.-43C>A glpK_c.-43C>A 2 upstream_gene_variant 4139798 NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2342 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1938 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 1 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK c.-43C>T glpK_c.-43C>T 2 upstream_gene_variant 4139798 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2307 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1909 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK c.444T>G glpK_c.444T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.-46C>T glpK_c.-46C>T 2 upstream_gene_variant 4139801 NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2270 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK c.495C>G glpK_c.495C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.752676762805054 0.0127620362920002 14.460605698152 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.495C>T glpK_c.495C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 10368 15602 0 0 0.000355731413006942 0.999615581752947 0.999163472525571 0.999858912630967 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.27838118563185 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 5 7736 11869 0 0 0.000476732171726368 0.999578911908371 0.999017596768841 0.999863260157969 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.67480496260254 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.510C>T glpK_c.510C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 68 108 10300 15500 0.00655864197530864 0.00509653620608579 0.00830733396969762 0.993080471553049 0.991651777244172 0.994320422610542 0.386363636363636 0.31405955522582 0.462563954910942 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.947500898957209 0.688259997300872 1.2966330793757 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 37 83 7699 11791 0.00478283350568769 0.00336972515789112 0.00658653762182528 0.993009937678962 0.991342032174167 0.994428720465219 0.308333333333333 0.227255119633831 0.399136764531952 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.682715796293369 0.449889419228234 1.01856292673838 NA NA NA NA NA NA 374 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.525A>G glpK_c.525A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 2 10366 15606 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999871860584315 0.999537193839207 0.999984481345552 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.50549874590005 0.10909391082996 20.7696540777406 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.528G>A glpK_c.528G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.528G>T glpK_c.528G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.54C>T glpK_c.54C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.558C>G glpK_c.558C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.570G>A glpK_c.570G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.570G>C glpK_c.570G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.597C>T glpK_c.597C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.-5A>G glpK_c.-5A>G 2 upstream_gene_variant 4139760 1 4 1 3 7 3 10361 15605 0.000675154320987654 0.000271488767107418 0.00139057803317028 0.999807790876473 0.99943838714673 0.999960360103688 0.7 0.347547149940002 0.933260488822265 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.50204291735032 0.00956706916260692 6.25376244972762 1 973.5 2512 False False 3.51430042145224 0.802019002880655 21.0638674909524 9.65064659332175e-05 2.44332918880599e-06 0.000537581013405577 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 1 3 7 3 7729 11871 0.000904860392967942 0.000363875741427306 0.00186346392020999 0.999747347145022 0.999261820436506 0.999947893876346 0.7 0.347547149940002 0.933260488822265 0.25 0.00630946320970987 0.805879550316756 0.25 0.00630946320970987 0.805879550316756 0.511967913054729 0.00975577936832002 6.37776925343821 1 806.5 2071 False False 0 0 0 0 0 0 0 3.5837753913831 0.81778515516938 21.4815595723006 0.000129366106080207 3.27526086973536e-06 0.000720568705238285 0.999747347145022 0.999261820436506 0.999947893876346 21 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK c.609C>T glpK_c.609C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.624A>C glpK_c.624A>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 7 8 10361 15600 0.000675154320987654 0.000271488767107418 0.00139057803317028 0.999487442337262 0.998990308225149 0.99977868883794 0.466666666666666 0.212666729519307 0.734138652722603 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.31744040150564 0.406565769402037 4.1590217879041 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.63C>T glpK_c.63C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.649C>T glpK_c.649C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 5 0 10363 15608 0.000482253086419753 0.000156604214122162 0.00112505595550109 1 0.99976368249849 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.37979907306709 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 5 0 7731 11874 0.000646328852119958 0.0002098934625097 0.00150766595359595 1 0.999689379610589 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.40693962335604 Inf NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.658T>C glpK_c.658T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.6C>G glpK_c.6C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.702G>C glpK_c.702G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.17274275317631 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.708G>A glpK_c.708G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.717T>C glpK_c.717T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.717T>G glpK_c.717T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.726C>T glpK_c.726C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.741G>T glpK_c.741G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 8 20 10360 15588 0.000771604938271604 0.00033318123262376 0.00151980017311994 0.998718605843157 0.998021680992693 0.99921712098903 0.285714285714285 0.132236512571125 0.48666831544894 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.601853281853281 0.229211813436689 1.42718417169879 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 8 19 7728 11855 0.00103412616339193 0.000446564649135067 0.00203661849802302 0.99839986525181 0.997502314270442 0.999036348042965 0.296296296296296 0.137526553940579 0.501813666370001 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.645908248883077 0.244472709105557 1.54616966355897 NA NA NA NA NA NA 14 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.747C>G glpK_c.747C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.75C>A glpK_c.75C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.75C>T glpK_c.75C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.762G>A glpK_c.762G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.765C>T glpK_c.765C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.50544998553101 0.0191837380556942 118.074698097101 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.789T>C glpK_c.789T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 10368 15604 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.28044779470556 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 7736 11870 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.32513012450998 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.795C>T glpK_c.795C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.-7A>G glpK_c.-7A>G 2 upstream_gene_variant 4139762 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK c.843T>C glpK_c.843T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.84C>T glpK_c.84C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.852C>T glpK_c.852C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.859C>T glpK_c.859C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.873C>T glpK_c.873C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.50544998553101 0.0191837380556942 118.074698097101 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.87C>T glpK_c.87C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 10368 15603 0 0 0.000355731413006942 0.999679651460789 0.999252573060182 0.999895975781355 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.64266120859479 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 7736 11870 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.32513012450998 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.891A>G glpK_c.891A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 1 10365 15607 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999935930292158 0.99964307871082 0.999998377896754 0.75 0.194120449683243 0.99369053679029 NA NA NA NA NA NA NA NA NA NA NA NA False False 4.51722141823444 0.362625225225282 236.854590713406 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 7733 11874 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 1 0.999689379610589 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.634338273987677 Inf NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.-8T>C glpK_c.-8T>C 2 upstream_gene_variant 4139763 NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2364 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK c.900C>T glpK_c.900C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 1 10366 15607 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999935930292158 0.99964307871082 0.999998377896754 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.01119043025274 0.156729426968348 177.474331043773 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.921C>T glpK_c.921C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.936C>T glpK_c.936C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.969C>T glpK_c.969C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.96C>T glpK_c.96C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 3 10367 15605 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999807790876473 0.99943838714673 0.999960360103688 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.501752355229735 0.00956153582768186 6.25014259670444 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.978C>T glpK_c.978C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin glpK c.-9T>G glpK_c.-9T>G 2 upstream_gene_variant 4139764 NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2361 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1951 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK deletion glpK_deletion 2 feature_ablation (see "Genomic_coordinates" sheet) NA 0 0 0 1 3 10367 15605 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999807790876473 0.99943838714673 0.999960360103688 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2343 2512 False False 0.501752355229735 0.00956153582768186 6.25014259670444 0 0 0.000355765720726338 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 3 7735 11871 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999747347145022 0.999261820436506 0.999947893876346 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1939 2071 False False 0 0 0 0 0 0 0 0.511570782159017 0.0097482170621519 6.37282132403124 0 0 0.000476793790149404 0.999747347145022 0.999261820436506 0.999947893876346 5 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK LoF glpK_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 62 3 59 196 149 10172 15459 0.0189043209876543 0.0163704738054127 0.0217132202576658 0.990453613531522 0.988801151903094 0.991919189326252 0.568115942028985 0.514001666679113 0.6210509243364 0.0483870967741935 0.0100919463109757 0.134961947715069 0.0197368421052631 0.00408885332301026 0.0565941739811447 0.0772759386018115 0.0154725454673356 0.237224794525464 5.56908066814901e-10 13 2512 True False 1.99914754807908 1.60485404022915 2.49435017022 0.000294840294840294 6.08072847571626e-05 0.000861404294467149 0.990453613531522 0.988801151903094 0.991919189326252 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 40 2 38 114 80 7622 11794 0.014736297828335 0.012170596699197 0.0176764690480694 0.993262590533939 0.991621627162735 0.994654144186181 0.587628865979381 0.514883037072642 0.657654305251388 0.05 0.00611364659935083 0.169196863959417 0.024390243902439 0.00296754155142273 0.0853432249550826 0.0814401524672347 0.00951131129273998 0.315290895458904 9.45497239822365e-07 17 2071 True False 0 0 0 0 0 0 0 2.20499212805038 1.63968572821005 2.97667136943974 0.000262329485834207 3.17708967644251e-05 0.000947299655170834 0.993262590533939 0.991621627162735 0.994654144186181 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Ala11Val glpK_p.Ala11Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 5 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Ala164Thr glpK_p.Ala164Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2264 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1884 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Ala171Val glpK_p.Ala171Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 10367 15605 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999807790876473 0.99943838714673 0.999960360103688 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.64334605529666 0.280505932748473 259.5 2512 False False 0.501752355229735 0.00956153582768186 6.25014259670444 0 0 0.000355765720726338 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 3 7735 11871 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999747347145022 0.999261820436506 0.999947893876346 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.7148618120425 0.283378435813045 205.5 2071 False False 0 0 0 0 0 0 0 0.511570782159017 0.0097482170621519 6.37282132403124 0 0 0.000476793790149404 0.999747347145022 0.999261820436506 0.999947893876346 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Ala245Thr glpK_p.Ala245Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2292 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1901 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Ala277Gly glpK_p.Ala277Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Ala318Thr glpK_p.Ala318Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2383 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1968 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Ala318Val glpK_p.Ala318Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2322 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Ala324Thr glpK_p.Ala324Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2281 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1895 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 1 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Ala364Val glpK_p.Ala364Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 4 10368 15604 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 58.6464905326305 1 973.5 2512 False False 0 0 2.28044779470556 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1975 2071 False False 0 0 0 0 0 0 0 0 0 3.71438150990605 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 6 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Ala377Val glpK_p.Ala377Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 58.6540000158548 1 973.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1929 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Ala37Val glpK_p.Ala37Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2323 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1922 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Ala396fs glpK_p.Ala396fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Ala396Gly glpK_p.Ala396Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2298 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1904 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Ala396Ser glpK_p.Ala396Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Ala400Val glpK_p.Ala400Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2381 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Ala40Ser glpK_p.Ala40Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 10366 15607 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999935930292158 0.99964307871082 0.999998377896754 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 58.6690617185945 1 973.5 2512 False False 3.01119043025274 0.156729426968348 177.474331043773 0 0 0.000355800035063835 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 7734 11873 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999915782381674 0.999530859783396 0.999997867796783 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 59.821615810862 1 806.5 2071 False False 0 0 0 0 0 0 0 3.07033876389966 0.159799628612092 180.959738606129 0 0 0.000476855424503066 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Ala453Thr glpK_p.Ala453Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 58.6596525903968 1 973.5 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 0 0 0.000355765720726338 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 59.8088564761233 1 806.5 2071 False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 0 0 0.000476793790149404 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Ala453Val glpK_p.Ala453Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2376 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Ala457Ser glpK_p.Ala457Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2318 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1918 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Ala457Val glpK_p.Ala457Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Ala463Glu glpK_p.Ala463Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.6429945931141 0.280491932584249 243 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.71438150990605 0.283358886007265 193.5 2071 False False 0 0 0 0 0 0 0 0 0 3.71438150990605 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Ala463Val glpK_p.Ala463Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2384 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1969 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Ala464Gly glpK_p.Ala464Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 10368 15603 0 0 0.000355731413006942 0.999679651460789 0.999252573060182 0.999895975781355 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.64266120859479 0.164659119890409 198.5 2512 False False 0 0 1.64266120859479 0 0 0.000355731413006942 0.999679651460789 0.999252573060182 0.999895975781355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.71438150990605 0.283358886007265 193.5 2071 False False 0 0 0 0 0 0 0 0 0 3.71438150990605 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Ala467Val glpK_p.Ala467Val 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2365 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1954 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Ala472Glu glpK_p.Ala472Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Ala472Pro glpK_p.Ala472Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Ala53Val glpK_p.Ala53Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2313 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1914 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Ala77Val glpK_p.Ala77Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2393 2512 False False Inf 0.282736080598822 Inf 0 0 0.000355800035063835 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Ala86Val glpK_p.Ala86Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Ala87Val glpK_p.Ala87Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2282 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1896 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 1 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Arg102Trp glpK_p.Arg102Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2326 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1924 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Arg118His glpK_p.Arg118His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Arg131Ser glpK_p.Arg131Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.6429945931141 0.280491932584249 243 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Arg136Ser glpK_p.Arg136Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2310 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1911 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Arg137Cys glpK_p.Arg137Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2366 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1955 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Arg202Gln glpK_p.Arg202Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2299 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Arg225Trp glpK_p.Arg225Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Arg297Gln glpK_p.Arg297Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2327 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1925 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Arg406Cys glpK_p.Arg406Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2276 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1894 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Arg478Gln glpK_p.Arg478Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2370 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 0 0 0.000355765720726338 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 59.801132462225 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Arg52Trp glpK_p.Arg52Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2344 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Arg66Ser glpK_p.Arg66Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Asn110fs glpK_p.Asn110fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2319 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1919 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Asn183Ser glpK_p.Asn183Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2300 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Asn199fs glpK_p.Asn199fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2267 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1887 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Asn299Asp glpK_p.Asn299Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 8 0 10360 15608 0.000771604938271604 0.00033318123262376 0.00151980017311994 1 0.99976368249849 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 2330 2512 False False Inf 2.57069745416703 Inf 0 0 0.000356006060176228 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 6 0 7730 11874 0.00077559462254395 0.000284681048736677 0.00168737281383633 1 0.999689379610589 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 1930 2071 False False 0 0 0 0 0 0 0 Inf 1.80798545886233 Inf 0 0 0.000477102121347592 1 0.999689379610589 1 29 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Asn312Lys glpK_p.Asn312Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2389 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1972 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Asn356Ser glpK_p.Asn356Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2377 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1962 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Asn388Lys glpK_p.Asn388Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 4 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Asn59Asp glpK_p.Asn59Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Asn59Ser glpK_p.Asn59Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2308 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Asn79fs glpK_p.Asn79fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2283 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1897 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Asn92Ser glpK_p.Asn92Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2284 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1898 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Asp120Ala glpK_p.Asp120Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Asp129His glpK_p.Asp129His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Asp160Asn glpK_p.Asp160Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 4 10367 15604 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999743721168631 0.999343955596995 0.999930168370675 0.2 0.00505076337946806 0.716417936118089 0 0 0.975 0 0 0.602364635616474 0 0 58.6521423841362 1 610 2512 False False 0.376290151442075 0.00764455959995544 3.80334957923739 0 0 0.000355765720726338 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 4 7736 11870 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 59.7910684069526 1 512 2071 False False 0 0 0 0 0 0 0 0 0 2.32513012450998 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 2 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Asp170Glu glpK_p.Asp170Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2359 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1949 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Asp177Asn glpK_p.Asp177Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 58.6502452744631 1 973.5 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1963 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Asp177Gly glpK_p.Asp177Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2271 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1889 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Asp214Val glpK_p.Asp214Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2268 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Asp215Gly glpK_p.Asp215Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2390 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1973 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Asp3Asn glpK_p.Asp3Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2367 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1956 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Asp407Asn glpK_p.Asp407Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.6429945931141 0.280491932584249 243 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Asp407Glu glpK_p.Asp407Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Asp446Tyr glpK_p.Asp446Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2394 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1976 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Asp493fs glpK_p.Asp493fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2395 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Asp493Gly glpK_p.Asp493Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Asp84Glu glpK_p.Asp84Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 10 0 10 0 12 10368 15596 0 0 0.000355731413006942 0.999231163505894 0.998657382918185 0.999602669866138 0 0 0.264648469397051 0 0 0.30849710781876 0 0 0.264648469397051 0 0 0.671273699771388 0.00776945288811197 60.5 2512 False False 0 0 0.541504747593943 0 0 0.000355731413006942 0.999231163505894 0.998657382918185 0.999602669866138 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 6 7736 11868 0 0 0.000476732171726368 0.999494694290045 0.998900489118281 0.999814539856352 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 1.67466390164345 0.164220338004954 162.5 2071 False False 0 0 0 0 0 0 0 0 0 1.30338194607257 0 0 0.000476732171726368 0.999494694290045 0.998900489118281 0.999814539856352 32 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Cys271Arg glpK_p.Cys271Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Cys271Gly glpK_p.Cys271Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2348 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1943 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Cys271Tyr glpK_p.Cys271Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2355 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1945 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Cys29Tyr glpK_p.Cys29Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 63 46 10305 15562 0.00607638888888888 0.0046723301590596 0.00776773481999848 0.997052793439262 0.996070774230486 0.997841490977402 0.577981651376146 0.479633631127642 0.671983628571896 NA NA NA 0 0 0.0770618270519006 NA NA NA NA 2277 2512 False False 2.06823618758306 1.39063274375909 3.09630310009396 0 0 0.00035790580097538 0.997052793439262 0.996070774230486 0.997841490977402 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 22 0 22 56 30 7680 11844 0.00723888314374353 0.00547267327183907 0.00939012257082594 0.997473471450227 0.996395171968696 0.998294732496074 0.651162790697674 0.540772239780411 0.750813354779753 0 0 0.154372512815574 0 0 0.115703308222027 0 0 0.281655588485985 2.42692628560123e-05 27 2071 True False 0 0 0 0 0 0 0 2.87875 1.81402191953486 4.65134123573585 0 0 0.000480207509036754 0.997473471450227 0.996395171968696 0.998294732496074 69 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Cys307Phe glpK_p.Cys307Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Gln153Pro glpK_p.Gln153Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2285 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Gln153* glpK_p.Gln153* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Gln262Arg glpK_p.Gln262Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2371 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1958 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 1 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Gln269* glpK_p.Gln269* 2 stop_gained (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2295 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Gln336His glpK_p.Gln336His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Gln345Lys glpK_p.Gln345Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Gln345Pro glpK_p.Gln345Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2288 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1899 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Gln404Glu glpK_p.Gln404Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Gln421His glpK_p.Gln421His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2331 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Gln508* glpK_p.Gln508* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Gln9Glu glpK_p.Gln9Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2272 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1890 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 3 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Glu157Gly glpK_p.Glu157Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2396 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1977 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Glu209Lys glpK_p.Glu209Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 16 14 10352 15594 0.0015432098765432 0.000882326976774945 0.00250486960174422 0.99910302409021 0.99849548434986 0.999509530910458 0.533333333333333 0.343255238160734 0.716581920816462 0 0 0.409616397225003 0 0 0.231635761650116 0 0 1.04541789527181 0.0468881284954284 104 2512 False False 1.7215720909693 0.786936507142919 3.81037712977263 0 0 0.000356281131763187 0.99910302409021 0.99849548434986 0.999509530910458 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 14 13 7722 11861 0.00180972078593588 0.000989733300678632 0.0030345415962221 0.998905170961765 0.998128536682641 0.999416924941029 0.518518518518518 0.319496546133383 0.71332745186806 0 0 0.4592581264399 0 0 0.24705263800047 0 0 1.30497540925184 0.0877322190270732 112 2071 False False 0 0 0 0 0 0 0 1.65415496184726 0.720692386838413 3.82423035988792 0 0 0.000477596281588063 0.998905170961765 0.998128536682641 0.999416924941029 48 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Glu216Gln glpK_p.Glu216Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2351 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Glu230Ala glpK_p.Glu230Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 5 10368 15603 0 0 0.000355731413006942 0.999679651460789 0.999252573060182 0.999895975781355 0 0 0.521823750104981 0 0 0.841886116991581 0 0 0.521823750104981 0 0 8.01410691564285 0.520309356547321 431 2512 False False 0 0 1.64266120859479 0 0 0.000355731413006942 0.999679651460789 0.999252573060182 0.999895975781355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 5 7736 11869 0 0 0.000476732171726368 0.999578911908371 0.999017596768841 0.999863260157969 0 0 0.521823750104981 0 0 0.841886116991581 0 0 0.521823750104981 0 0 8.17067779513396 0.522213785907881 351.5 2071 False False 0 0 0 0 0 0 0 0 0 1.67480496260254 0 0 0.000476732171726368 0.999578911908371 0.999017596768841 0.999863260157969 10 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Glu230Lys glpK_p.Glu230Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2301 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1905 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Glu276Gly glpK_p.Glu276Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 58.6634076928655 1 973.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 59.8138891519084 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 4 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Glu276Lys glpK_p.Glu276Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Glu347Ala glpK_p.Glu347Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Glu57Asp glpK_p.Glu57Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Glu65Gly glpK_p.Glu65Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Glu8Gly glpK_p.Glu8Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Gly105Glu glpK_p.Gly105Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Gly150Asp glpK_p.Gly150Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Gly161Arg glpK_p.Gly161Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2314 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1915 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Gly161Glu glpK_p.Gly161Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2391 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Gly187Glu glpK_p.Gly187Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2296 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Gly191dup glpK_p.Gly191dup 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 19 0 19 3 21 10365 15587 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.998654536135315 0.997944046996364 0.999166949785744 0.125 0.0265593149862489 0.323611358188833 0 0 0.176466911806965 0 0 0.161097615219079 0 0 0.322365121739879 7.33393683994336e-05 35 2512 True False 0.214830128867755 0.0410234910867936 0.719768059235124 0 0 0.000355834356021348 0.998654536135315 0.997944046996364 0.999166949785744 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 17 0 17 3 18 7733 11856 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 0.998484082870136 0.997605251464505 0.999101331744648 0.142857142857142 0.0304889676215155 0.363423987016981 0 0 0.195064322969093 0 0 0.185301968137852 0 0 0.371683110619653 0.00024394211555792 33 2071 True False 0 0 0 0 0 0 0 0.255528255528255 0.0482055232840638 0.875767603693653 0 0 0.000476917074793532 0.998484082870136 0.997605251464505 0.999101331744648 51 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Gly191fs glpK_p.Gly191fs 2 frameshift (see "Genomic_coordinates" sheet) 1 7 0 7 3 9 10365 15599 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.99942337262942 0.998905665124108 0.999736296428239 0.25 0.0548606445279927 0.571858461878189 0 0 0.409616397225003 0 0 0.336267116879942 0 0 1.04443841777574 0.0468714108965274 101 2512 False False 0.501656214825534 0.0873365176194113 2.0107394750464 0 0 0.000355834356021348 0.99942337262942 0.998905665124108 0.999736296428239 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 2 8 7734 11866 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999326259053394 0.998672895689377 0.999709083033384 0.2 0.0252107263268333 0.556095462307641 0 0 0.409616397225003 0 0 0.369416647552819 0 0 1.0648630726952 0.0472719114065843 85 2071 False False 0 0 0 0 0 0 0 0.383566071890354 0.0396726760071963 1.92279965315068 0 0 0.000476855424503066 0.999326259053394 0.998672895689377 0.999709083033384 25 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Gly23Asp glpK_p.Gly23Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2337 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1935 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Gly23Val glpK_p.Gly23Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Gly260Ala glpK_p.Gly260Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 0 9 10368 15599 0 0 0.000355731413006942 0.99942337262942 0.998905665124108 0.999736296428239 0 0 0.336267116879942 0 0 0.409616397225003 0 0 0.336267116879942 0 0 1.04413493904537 0.0468662925673343 96 2512 False False 0 0 0.762426796904344 0 0 0.000355731413006942 0.99942337262942 0.998905665124108 0.999736296428239 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 9 7736 11865 0 0 0.000476732171726368 0.999242041435068 0.998561648359028 0.999653356368186 0 0 0.336267116879942 0 0 0.409616397225003 0 0 0.336267116879942 0 0 1.06449802949186 0.0472635601462793 79.5 2071 False False 0 0 0 0 0 0 0 0 0 0.777323095649869 0 0 0.000476732171726368 0.999242041435068 0.998561648359028 0.999653356368186 37 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Gly292Ser glpK_p.Gly292Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2315 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1916 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Gly301Val glpK_p.Gly301Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2402 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1981 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 1 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Gly311Glu glpK_p.Gly311Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Gly338Asp glpK_p.Gly338Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2338 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Gly342dup glpK_p.Gly342dup 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 58.6634076928655 1 973.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 59.8138891519084 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Gly357Ser glpK_p.Gly357Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2397 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Gly358del glpK_p.Gly358del 2 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Gly36Ser glpK_p.Gly36Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Gly417fs glpK_p.Gly417fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2320 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1920 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Gly417Ser glpK_p.Gly417Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2345 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1940 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Gly427Ser glpK_p.Gly427Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2265 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1885 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Gly465Ala glpK_p.Gly465Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Gly54Ser glpK_p.Gly54Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2352 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Gly89Glu glpK_p.Gly89Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.His103Tyr glpK_p.His103Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.His193fs glpK_p.His193fs 2 frameshift (see "Genomic_coordinates" sheet) 1 3 0 3 2 3 10366 15605 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999807790876473 0.99943838714673 0.999960360103688 0.4 0.0527449505263169 0.853367200365326 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.64369758531757 0.280519937201876 266.5 2512 False False 1.00360151778249 0.0837840645585397 8.76371184924575 0 0 0.000355800035063835 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 10 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.His35Tyr glpK_p.His35Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.His42Asp glpK_p.His42Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2398 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1978 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.His42Tyr glpK_p.His42Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2324 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1923 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Ile112Thr glpK_p.Ile112Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2316 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Ile223Thr glpK_p.Ile223Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2286 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Ile255Leu glpK_p.Ile255Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Ile323Val glpK_p.Ile323Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2353 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 0 0 0.000355765720726338 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Ile429Thr glpK_p.Ile429Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2385 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1970 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Ile49Thr glpK_p.Ile49Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 58.6634076928655 1 973.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 59.8138891519084 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Ile5Leu glpK_p.Ile5Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Ile90fs glpK_p.Ile90fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2278 2512 False False Inf 0.282736080598822 Inf 0 0 0.000355800035063835 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Leu141Met glpK_p.Leu141Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 58.6634076928655 1 973.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 59.8138891519084 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Leu152Arg glpK_p.Leu152Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2287 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Leu172Phe glpK_p.Leu172Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2311 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1912 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Leu218Val glpK_p.Leu218Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2309 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1910 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Leu228Ala glpK_p.Leu228Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2289 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1900 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Leu228Val glpK_p.Leu228Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 189 9 180 66 270 10302 15338 0.00636574074074074 0.00492658380030099 0.00809175853824217 0.982701178882624 0.980531325840137 0.984688339884058 0.196428571428571 0.155299662750902 0.24300170729874 0.0476190476190476 0.0220026504287861 0.0884685893194653 0.032258064516129 0.0148544914107892 0.0603505722033735 0.0744418559503009 0.0334822665620035 0.14461435074982 4.02243031498401e-29 9 2512 True False 0.363937962423693 0.273386942556994 0.47854018971622 0.000872854233343031 0.000399199747453033 0.00165629966116867 0.982701178882624 0.980531325840137 0.984688339884058 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 191 9 182 64 270 7672 11604 0.00827300930713547 0.00637688726484332 0.0105523293811958 0.977261243052046 0.974417939158543 0.979867104041859 0.191616766467065 0.150810006279274 0.237989958462157 0.0471204188481675 0.0217698453305072 0.0875621239692427 0.032258064516129 0.0148544914107892 0.0603505722033735 0.074794600602734 0.0336420224528784 0.145253744980179 3.16648523179945e-29 8 2071 True False 0 0 0 0 0 0 0 0.358521608156644 0.268212073617223 0.473206895651389 0.001171722431975 0.000535921658007708 0.00222312364252986 0.977261243052046 0.974417939158543 0.979867104041859 185 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Leu287Pro glpK_p.Leu287Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2380 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1966 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Leu333Ile glpK_p.Leu333Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 6 10368 15602 0 0 0.000355731413006942 0.999615581752947 0.999163472525571 0.999858912630967 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 1.64255595449137 0.16466084696126 202 2512 False False 0 0 1.27838118563185 0 0 0.000355731413006942 0.999615581752947 0.999163472525571 0.999858912630967 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 7736 11870 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.71406862449918 0.283346149162266 180.5 2071 False False 0 0 0 0 0 0 0 0 0 2.32513012450998 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 5 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Leu349Pro glpK_p.Leu349Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2293 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1902 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Leu393Val glpK_p.Leu393Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2372 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Leu398Met glpK_p.Leu398Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Leu398Pro glpK_p.Leu398Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2317 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1917 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Leu466Phe glpK_p.Leu466Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 5 4 10363 15604 0.000482253086419753 0.000156604214122162 0.00112505595550109 0.999743721168631 0.999343955596995 0.999930168370675 0.555555555555555 0.212008506778868 0.863004337734833 0 0 0.841886116991581 0 0 0.602364635616474 0 0 8.01848757424605 0.52036223838333 559 2512 False False 1.88217697577921 0.404976076282378 9.48775936968954 0 0 0.000355903017804084 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 5 4 7731 11870 0.000646328852119958 0.0002098934625097 0.00150766595359595 0.999663129526697 0.999137704464366 0.999908206750254 0.555555555555555 0.212008506778868 0.863004337734833 0 0 0.841886116991581 0 0 0.602364635616474 0 0 8.17665118341247 0.522287470569969 464 2071 False False 0 0 0 0 0 0 0 1.91922131677661 0.41292222138363 9.6752271926289 0 0 0.000477040423209609 0.999663129526697 0.999137704464366 0.999908206750254 6 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Lys83Glu glpK_p.Lys83Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2294 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1903 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 3 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Met206Ile glpK_p.Met206Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2373 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1959 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Met227Ile glpK_p.Met227Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 10368 15604 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 8.01462049278838 0.520315555582948 435.5 2512 False False 0 0 2.28044779470556 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1967 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 1 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Met266fs glpK_p.Met266fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2266 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1886 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Met30Val glpK_p.Met30Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Met412Ile glpK_p.Met412Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.6429945931141 0.280491932584249 243 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 4 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Phe16Leu glpK_p.Phe16Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Phe16Ser glpK_p.Phe16Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Phe173Tyr glpK_p.Phe173Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 58.6540000158548 1 973.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 59.801132462225 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Phe32Cys glpK_p.Phe32Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2332 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1931 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Phe365Leu glpK_p.Phe365Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Phe369Leu glpK_p.Phe369Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Pro236Ala glpK_p.Pro236Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2356 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1946 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Pro239Arg glpK_p.Pro239Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2374 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1960 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Pro254fs glpK_p.Pro254fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Pro254Gln glpK_p.Pro254Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Pro254Leu glpK_p.Pro254Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Pro274Leu glpK_p.Pro274Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2349 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1944 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Pro315Leu glpK_p.Pro315Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 2 4 10366 15604 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999743721168631 0.999343955596995 0.999930168370675 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.6434640919271 0.280510633342664 264 2512 False False 0.752652903723712 0.0680519547847045 5.25297485318028 0 0 0.000355800035063835 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 4 7736 11870 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 0 0 0.602364635616474 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.71406862449918 0.283346149162266 180.5 2071 False False 0 0 0 0 0 0 0 0 0 2.32513012450998 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 1 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Pro363Arg glpK_p.Pro363Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2382 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Pro363Ser glpK_p.Pro363Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2375 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1961 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Pro371Ser glpK_p.Pro371Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2350 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Pro474Leu glpK_p.Pro474Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 3 2 10365 15606 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999871860584315 0.999537193839207 0.999984481345552 0.6 0.146632799634673 0.947255049473683 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01796774552954 0.520355963963549 557.5 2512 False False 2.25846599131693 0.258657968313028 27.0476864113414 0 0 0.000355834356021348 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 3 2 7733 11872 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 0.999831564763348 0.99939168785815 0.999979601060482 0.6 0.146632799634673 0.947255049473683 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17591350844661 0.522278372383967 463 2071 False False 0 0 0 0 0 0 0 2.30285788180525 0.263724298106321 27.579548092527 0 0 0.000476917074793532 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Pro489Arg glpK_p.Pro489Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2325 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Pro51Leu glpK_p.Pro51Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Pro82Leu glpK_p.Pro82Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Ser124Leu glpK_p.Ser124Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2302 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1906 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Ser124Pro glpK_p.Ser124Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 2 0 2 2 10366 15606 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999871860584315 0.999537193839207 0.999984481345552 0.5 0.067585986488543 0.932414013511457 1 0.158113883008419 1 0.5 0.067585986488543 0.932414013511457 Inf 0.282699849866807 Inf 0.159326176959873 190 2512 False False 1.50549874590005 0.10909391082996 20.7696540777406 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1947 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 2 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Ser2fs glpK_p.Ser2fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2346 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1941 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Ser2Phe glpK_p.Ser2Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2339 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1936 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Ser2Thr glpK_p.Ser2Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2273 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1891 2071 False False 0 0 0 0 0 0 0 0 0 3.71438150990605 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Ser366Cys glpK_p.Ser366Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2290 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Ser416Ala glpK_p.Ser416Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2347 2512 False False Inf 0.282736080598822 Inf 0 0 0.000355800035063835 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1942 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0 0 0.000476855424503066 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Ser416Tyr glpK_p.Ser416Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 58.6596525903968 1 973.5 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 0 0 0.000355765720726338 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Ser517Cys glpK_p.Ser517Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Ser73Trp glpK_p.Ser73Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2303 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Thr145Ser glpK_p.Thr145Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2297 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Thr195fs glpK_p.Thr195fs 2 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Thr203Ala glpK_p.Thr203Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2403 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1982 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 1 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Thr243Lys glpK_p.Thr243Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2328 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1926 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Thr24Ala glpK_p.Thr24Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2399 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1979 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Thr256Ile glpK_p.Thr256Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2304 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1907 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Thr280Ala glpK_p.Thr280Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 58.6540000158548 1 973.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 59.801132462225 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Thr280Asn glpK_p.Thr280Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2368 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Thr291Asn glpK_p.Thr291Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2404 2512 False False Inf 0.282736080598822 Inf 0 0 0.000355800035063835 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1983 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0 0 0.000476855424503066 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Thr304Ala glpK_p.Thr304Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2362 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1952 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Thr326Ala glpK_p.Thr326Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2354 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Thr326fs glpK_p.Thr326fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2333 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Thr397Ala glpK_p.Thr397Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 3 2 10365 15606 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999871860584315 0.999537193839207 0.999984481345552 0.6 0.146632799634673 0.947255049473683 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01796774552954 0.520355963963549 557.5 2512 False False 2.25846599131693 0.258657968313028 27.0476864113414 0 0 0.000355834356021348 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 59.8138891519084 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Thr397Met glpK_p.Thr397Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Thr430Ala glpK_p.Thr430Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 7 1 6 5 11 10363 15597 0.000482253086419753 0.000156604214122162 0.00112505595550109 0.999295233213736 0.998739328260189 0.999648132128855 0.3125 0.110169954717117 0.586620636451358 0.142857142857142 0.00361029686190058 0.578723197043195 0.0833333333333333 0.00210759323186022 0.384796165150944 0.250844350091672 0.00545716209946625 2.06816570639572 0.255124199515811 219 2512 False False 0.684120954795469 0.186295413285231 2.13664291963113 9.6487842531841e-05 2.44285768625785e-06 0.000537477296220785 0.999295233213736 0.998739328260189 0.999648132128855 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 1 4 4 9 7732 11865 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.999242041435068 0.998561648359028 0.999653356368186 0.307692307692307 0.0909203945720966 0.614261661750705 0.2 0.00505076337946806 0.716417936118089 0.1 0.00252857854446178 0.445016117028195 0.383632953957578 0.00779337975335317 3.87784500565357 0.654464944565475 492 2071 False False 0 0 0 0 0 0 0 0.682014140369029 0.153421017946502 2.44469827824845 0.000129315918789603 3.27399024170944e-06 0.000720289244853199 0.999242041435068 0.998561648359028 0.999653356368186 36 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Thr430Ser glpK_p.Thr430Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 3 10367 15605 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999807790876473 0.99943838714673 0.999960360103688 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2305 2512 False False 0.501752355229735 0.00956153582768186 6.25014259670444 0 0 0.000355765720726338 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 3 7735 11871 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999747347145022 0.999261820436506 0.999947893876346 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1908 2071 False False 0 0 0 0 0 0 0 0.511570782159017 0.0097482170621519 6.37282132403124 0 0 0.000476793790149404 0.999747347145022 0.999261820436506 0.999947893876346 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Thr490Met glpK_p.Thr490Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Thr490Ser glpK_p.Thr490Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2306 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Thr510Ile glpK_p.Thr510Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2312 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1913 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Thr91Ala glpK_p.Thr91Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2321 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1921 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Thr97fs glpK_p.Thr97fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2274 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1892 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Trp100fs glpK_p.Trp100fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2340 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1937 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 1 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Trp114Arg glpK_p.Trp114Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Trp471Cys glpK_p.Trp471Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2334 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1932 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Trp487fs glpK_p.Trp487fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2400 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1980 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Trp513Arg glpK_p.Trp513Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 1 10365 15607 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999935930292158 0.99964307871082 0.999998377896754 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 58.6747168343076 1 610 2512 False False 4.51722141823444 0.362625225225282 236.854590713406 0 0 0.000355834356021348 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 59.8138891519084 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Trp64Leu glpK_p.Trp64Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Tyr109Cys glpK_p.Tyr109Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Tyr281* glpK_p.Tyr281* 2 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 58.6634076928655 1 973.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1927 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 1 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Tyr308His glpK_p.Tyr308His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2378 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1964 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Tyr372Cys glpK_p.Tyr372Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2392 2512 False False Inf 0.282736080598822 Inf 0 0 0.000355800035063835 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1974 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0 0 0.000476855424503066 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Tyr462fs glpK_p.Tyr462fs 2 frameshift (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2279 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Tyr500Cys glpK_p.Tyr500Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Val113Ala glpK_p.Val113Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2386 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Val113Ile glpK_p.Val113Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2387 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Val162Leu glpK_p.Val162Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2329 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1928 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Val192fs glpK_p.Val192fs 2 frameshift (see "Genomic_coordinates" sheet) 1 60 4 56 180 122 10188 15486 0.0173611111111111 0.0149350281607244 0.0200634027056008 0.99218349564326 0.99067416909511 0.993504761960756 0.596026490066225 0.538309879321935 0.651839891592248 0.0666666666666666 0.0184617775758815 0.161986755197728 0.0317460317460317 0.0087161607910839 0.0792880056526208 0.108573111223287 0.0285807783929188 0.293968517196807 1.26212753106956e-08 18 2512 True False 2.24265770723512 1.76966903282356 2.84983113407436 0.000392464678178963 0.000106943437868732 0.00100455779653462 0.99218349564326 0.99067416909511 0.993504761960756 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 35 2 33 106 58 7630 11816 0.0137021716649431 0.0112314803909054 0.0165485421268752 0.995115378137106 0.993690011198013 0.9962888746502 0.646341463414634 0.567986281648856 0.719301247792472 0.0571428571428571 0.00699676362830951 0.191571406345239 0.0333333333333333 0.00406262464209349 0.115281044419251 0.0938559911036975 0.0109074595798315 0.36715493644409 1.27925092524102e-05 23 2071 True False 0 0 0 0 0 0 0 2.83024359379943 2.03306000858262 3.97354816983652 0.000262054507337526 3.17375922840574e-05 0.000946307018477426 0.995115378137106 0.993690011198013 0.9962888746502 404 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Val192Met glpK_p.Val192Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Val253Leu glpK_p.Val253Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 10368 15603 0 0 0.000355731413006942 0.999679651460789 0.999252573060182 0.999895975781355 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 2.28030160110266 0.155688368476676 145 2512 False False 0 0 1.64266120859479 0 0 0.000355731413006942 0.999679651460789 0.999252573060182 0.999895975781355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 7736 11870 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.32513012450998 0.158605093840654 142 2071 False False 0 0 0 0 0 0 0 0 0 2.32513012450998 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Val267Ile glpK_p.Val267Ile 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2280 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Val270Phe glpK_p.Val270Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2335 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1933 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Val325Met glpK_p.Val325Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Val330Leu glpK_p.Val330Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2357 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1948 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Val353Ala glpK_p.Val353Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2358 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Val353Phe glpK_p.Val353Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Val362Ala glpK_p.Val362Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Val382Ala glpK_p.Val382Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Val39Leu glpK_p.Val39Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 2 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Val408Leu glpK_p.Val408Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2269 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1888 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Val418Asp glpK_p.Val418Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2388 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1971 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Val422Met glpK_p.Val422Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2379 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1965 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Val425Ala glpK_p.Val425Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.01513406993295 0.520321755085951 445 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.17205443383047 0.522230766108178 361 2071 False False 0 0 0 0 0 0 0 0 0 3.71438150990605 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Val442Met glpK_p.Val442Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 58.6634076928655 1 973.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Val452Leu glpK_p.Val452Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2341 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin glpK p.Val460Ala glpK_p.Val460Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 396 1909 9972 13699 0.0381944444444444 0.0345871382173192 0.0420639868962491 0.877690927729369 0.872448268657057 0.882792369122653 0.171800433839479 0.15660908966338 0.187830756220577 NA NA NA 0 0 0.00193049639764796 NA NA NA NA 2369 2512 False True 0.284967841858723 0.254335604478594 0.31871949420155 0 0 0.000369855318513073 0.877690927729369 0.872448268657057 0.882792369122653 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 331 1732 7405 10142 0.0427869700103412 0.0383856670096872 0.0475367804587227 0.854135085059794 0.847657466185592 0.860438568850186 0.160445952496364 0.144857067842068 0.177006101121202 NA NA NA 0 0 0.00212757152638081 NA NA NA NA 1957 2071 False True 0 1 1 0 0 0 0 0.261745153780059 0.231150663386847 0.295740058647656 0 0 0.000498036567105439 0.854135085059794 0.847657466185592 0.860438568850186 2787 5) Not assoc w R New NotAwR yes 5 +Streptomycin glpK p.Val460Met glpK_p.Val460Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2360 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1950 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rpsL c.-102C>T rpsL_c.-102C>T 1 upstream_gene_variant 781458 1 3 0 3 0 5 10368 15603 0 0 0.000355731413006942 0.999679651460789 0.999252573060182 0.999895975781355 0 0 0.521823750104981 0 0 0.707598226178713 0 0 0.521823750104981 0 0 3.64252769649333 0.280473333374422 223.5 2512 False False 0 0 1.64266120859479 0 0 0.000355731413006942 0.999679651460789 0.999252573060182 0.999895975781355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 59.801132462225 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 10 3) Uncertain significance No change no 1 +Streptomycin rpsL c.-104A>G rpsL_c.-104A>G 1 upstream_gene_variant 781456 0 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1451 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1192 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 6 3) Uncertain significance New Uncertain no 0 +Streptomycin rpsL c.-105A>G rpsL_c.-105A>G 1 upstream_gene_variant 781455 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1450 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1191 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rpsL c.-107C>G rpsL_c.-107C>G 1 upstream_gene_variant 781453 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rpsL c.111G>T rpsL_c.111G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin rpsL c.117C>T rpsL_c.117C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 16 32 10352 15576 0.0015432098765432 0.000882326976774945 0.00250486960174422 0.997949769349051 0.997106907825456 0.998597234103292 0.333333333333333 0.203959735580999 0.484108320446171 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.752318392581143 0.38530842863812 1.41279529182005 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 14 21 7722 11853 0.00180972078593588 0.000989733300678632 0.0030345415962221 0.998231430015159 0.997297816737997 0.998904904364371 0.4 0.238708110453341 0.5788822781179 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.02331002331002 0.480972361708213 2.11147958703678 NA NA NA NA NA NA 48 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin rpsL c.120C>T rpsL_c.120C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 10 10368 15598 0 0 0.000355731413006942 0.999359302921578 0.998822051949738 0.999692719453314 0 0 0.30849710781876 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.671359765315085 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 10 7736 11864 0 0 0.000476732171726368 0.999157823816742 0.998451755191613 0.9995960722577 0 0 0.30849710781876 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.684441233813457 NA NA NA NA NA NA 15 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin rpsL c.-124C>A rpsL_c.-124C>A 1 upstream_gene_variant 781436 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1419 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1162 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rpsL c.-125G>C rpsL_c.-125G>C 1 upstream_gene_variant 781435 0 0 0 0 40 84 10328 15524 0.00385802469135802 0.00275761673666364 0.00524986727088073 0.99461814454126 0.993341169017186 0.995705017440307 0.32258064516129 0.241450790026312 0.412411539325678 NA NA NA 0 0 0.042964919629565 NA NA NA NA 1448 2512 False True 0.715761130168566 0.47802357019243 1.05596348733247 0 0 0.000357108902890877 0.99461814454126 0.993341169017186 0.995705017440307 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 7 60 7729 11814 0.000904860392967942 0.000363875741427306 0.00186346392020999 0.994946942900454 0.993500436941174 0.99614183595874 0.104477611940298 0.0430493784189682 0.20348920453585 NA NA NA 0 0 0.0596294922861668 NA NA NA NA 1189 2071 False True 0 1 1 0 0 0 0 0.178328373657653 0.068707058340431 0.390787398724445 0 0 0.000477163835447126 0.994946942900454 0.993500436941174 0.99614183595874 114 5) Not assoc w R UP from Uncertain to NotAwR yes 4 +Streptomycin rpsL c.126G>A rpsL_c.126G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin rpsL c.126G>T rpsL_c.126G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin rpsL c.-127C>G rpsL_c.-127C>G 1 upstream_gene_variant 781433 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rpsL c.-127C>T rpsL_c.-127C>T 1 upstream_gene_variant 781433 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rpsL c.-133G>A rpsL_c.-133G>A 1 upstream_gene_variant 781427 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1428 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1172 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rpsL c.135G>A rpsL_c.135G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 5 23 10363 15585 0.000482253086419753 0.000156604214122162 0.00112505595550109 0.998526396719631 0.997789687011067 0.999065639764335 0.178571428571428 0.0606429088192075 0.368933349419203 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.326936551023918 0.09706051955588 0.879623579495696 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 5 22 7731 11852 0.000646328852119958 0.0002098934625097 0.00150766595359595 0.998147212396833 0.997196193207206 0.998838514973534 0.185185185185185 0.0630000065376768 0.380829879093994 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.34842017379852 0.103055979551593 0.943499513309115 NA NA NA NA NA NA 25 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin rpsL c.-137A>C rpsL_c.-137A>C 1 upstream_gene_variant 781423 0 0 0 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1446 2512 False False Inf 0.282736080598822 Inf 0 0 0.000355800035063835 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rpsL c.-137A>G rpsL_c.-137A>G 1 upstream_gene_variant 781423 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1414 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1159 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rpsL c.-138A>C rpsL_c.-138A>C 1 upstream_gene_variant 781422 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rpsL c.-139C>A rpsL_c.-139C>A 1 upstream_gene_variant 781421 1 19 2 17 28 22 10340 15586 0.00270061728395061 0.00179526773351123 0.00390079652146021 0.998590466427473 0.997866722379978 0.999116448603187 0.56 0.412544122941673 0.700092779072456 0.105263157894736 0.0130121643717774 0.331376664456765 0.0833333333333333 0.0102563412812501 0.269972801557603 0.177335305495505 0.0198739004340086 0.747345447340906 0.00857797762483016 65 2512 False False 1.91844557763319 1.05787659140742 3.52062485535479 0.000193386192225875 2.3420823136731e-05 0.000698400983719754 0.998590466427473 0.997866722379978 0.999116448603187 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 14 1 13 21 18 7715 11856 0.00271458117890382 0.00168112962543325 0.00414654804366048 0.998484082870136 0.997605251464505 0.999101331744648 0.538461538461538 0.371810747206518 0.699052196992492 0.0714285714285714 0.00180678065912538 0.338684489931821 0.0526315789473684 0.00133162880417942 0.260280654195214 0.118211276733635 0.00278541638439136 0.787379929260282 0.0124676829956348 60 2071 False False 0 0 0 0 0 0 0 1.79287103046014 0.908855028107585 3.57211396873572 0.000129600829445308 3.28120353134094e-06 0.000721875726169029 0.998484082870136 0.997605251464505 0.999101331744648 52 3) Uncertain significance No change no 1 +Streptomycin rpsL c.-139C>G rpsL_c.-139C>G 1 upstream_gene_variant 781421 0 0 0 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1440 2512 False False Inf 0.282736080598822 Inf 0 0 0.000355800035063835 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1182 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0 0 0.000476855424503066 1 0.999689379610589 1 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rpsL c.-139C>T rpsL_c.-139C>T 1 upstream_gene_variant 781421 1 3 0 3 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.6429945931141 0.280491932584249 243 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.71438150990605 0.283358886007265 193.5 2071 False False 0 0 0 0 0 0 0 0 0 3.71438150990605 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 3 3) Uncertain significance No change no 1 +Streptomycin rpsL c.-146G>A rpsL_c.-146G>A 1 upstream_gene_variant 781414 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance No change no 1 +Streptomycin rpsL c.-146G>T rpsL_c.-146G>T 1 upstream_gene_variant 781414 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rpsL c.-147T>C rpsL_c.-147T>C 1 upstream_gene_variant 781413 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rpsL c.-149G>A rpsL_c.-149G>A 1 upstream_gene_variant 781411 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1420 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1163 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rpsL c.150G>C rpsL_c.150G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin rpsL c.-153C>T rpsL_c.-153C>T 1 upstream_gene_variant 781407 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1421 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1164 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rpsL c.-154_-153insC rpsL_c.-154_-153insC 1 upstream_gene_variant 781406 1 28 0 28 17 32 10351 15576 0.00163966049382716 0.0009554436768022 0.00262396149717064 0.997949769349051 0.997106907825456 0.998597234103292 0.346938775510204 0.21672437810748 0.496387197719464 0 0 0.123436118500263 0 0 0.108881160679352 0 0 0.211986334567921 7.22181908615017e-07 23 2512 True False 0.799415515409139 0.416131568610115 1.4840971679445 0 0 0.000356315545602427 0.997949769349051 0.997106907825456 0.998597234103292 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 23 0 23 12 27 7724 11847 0.0015511892450879 0.000801770903407866 0.00270804603829147 0.997726124305204 0.996693341822076 0.998500983311891 0.307692307692307 0.170195902964694 0.475691391541684 0 0 0.148185128915224 0 0 0.127702867615432 0 0 0.266931084919681 1.32783556154068e-05 24 2071 True False 0 0 0 0 0 0 0 0.681684791990333 0.314422547206388 1.39258956031246 0 0 0.000477472645584994 0.997726124305204 0.996693341822076 0.998500983311891 27 3) Uncertain significance No change no 1 +Streptomycin rpsL c.-155G>A rpsL_c.-155G>A 1 upstream_gene_variant 781405 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rpsL c.-155G>C rpsL_c.-155G>C 1 upstream_gene_variant 781405 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rpsL c.-156G>A rpsL_c.-156G>A 1 upstream_gene_variant 781404 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rpsL c.-156G>C rpsL_c.-156G>C 1 upstream_gene_variant 781404 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rpsL c.-161T>C rpsL_c.-161T>C 1 upstream_gene_variant 781399 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1436 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1179 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rpsL c.-161T>G rpsL_c.-161T>G 1 upstream_gene_variant 781399 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rpsL c.-162A>G rpsL_c.-162A>G 1 upstream_gene_variant 781398 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rpsL c.-165T>C rpsL_c.-165T>C 1 upstream_gene_variant 781395 1 5940 262 5678 10244 15380 124 228 0.98804012345679 0.985756757144507 0.990042829049625 0.0146078933880061 0.0127845140489937 0.01661530130041 0.399781454886044 0.393775807505838 0.405809838538127 0.0441077441077441 0.0390268951010692 0.0496421724269096 0.0167497762434471 0.0147969459749974 0.0188851630481958 0.084843595541365 0.0655857846897661 0.110212623072646 1.08222158843337e-66 NA NA False True 1.22469063299635 0.978342222122389 1.53891281775275 0.678756476683937 0.629638262088307 0.725107100628809 0.0146078933880061 0.0127845140489937 0.01661530130041 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 4568 179 4389 7623 11673 113 201 0.985392967942089 0.982464330115069 0.987946987014734 0.0169277412834765 0.0146843556136209 0.0194122087447459 0.395055970149253 0.388148648882177 0.401994927900669 0.039185639229422 0.0337456816267963 0.0452242591171652 0.0151029362132973 0.0129847419373268 0.0174638991704344 0.0725445956000217 0.0547011957001964 0.0965654968512796 6.36170618629998e-65 NA NA False True 0 0 0 1 0 1 0 1.16161188856517 0.916208061558099 1.47869397926552 0.613013698630137 0.554518449168461 0.669190644443864 0.0169277412834765 0.0146843556136209 0.0194122087447459 26194 Not assoc w R 5) Not assoc w R No change yes 1 +Streptomycin rpsL c.-166C>T rpsL_c.-166C>T 1 upstream_gene_variant 781394 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin rpsL c.-168C>T rpsL_c.-168C>T 1 upstream_gene_variant 781392 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1437 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rpsL c.-173G>A rpsL_c.-173G>A 1 upstream_gene_variant 781387 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Streptomycin rpsL c.-175C>G rpsL_c.-175C>G 1 upstream_gene_variant 781385 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rpsL c.-177G>C rpsL_c.-177G>C 1 upstream_gene_variant 781383 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1454 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1195 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 2 3) Uncertain significance New Uncertain no 0 +Streptomycin rpsL c.-178T>C rpsL_c.-178T>C 1 upstream_gene_variant 781382 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rpsL c.-178T>G rpsL_c.-178T>G 1 upstream_gene_variant 781382 0 0 0 0 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1432 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 0 0 0.000355765720726338 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1175 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rpsL c.-179_-177delCTG rpsL_c.-179_-177delCTG 1 upstream_gene_variant 781380 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1425 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1168 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rpsL c.-179C>T rpsL_c.-179C>T 1 upstream_gene_variant 781381 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rpsL c.-180C>T rpsL_c.-180C>T 1 upstream_gene_variant 781380 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 4 3) Uncertain significance No change no 1 +Streptomycin rpsL c.180G>A rpsL_c.180G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin rpsL c.-182T>C rpsL_c.-182T>C 1 upstream_gene_variant 781378 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1417 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1161 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rpsL c.-183G>A rpsL_c.-183G>A 1 upstream_gene_variant 781377 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rpsL c.-185T>A rpsL_c.-185T>A 1 upstream_gene_variant 781375 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rpsL c.-187G>C rpsL_c.-187G>C 1 upstream_gene_variant 781373 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin rpsL c.-188T>C rpsL_c.-188T>C 1 upstream_gene_variant 781372 1 4 0 4 0 5 10368 15603 0 0 0.000355731413006942 0.999679651460789 0.999252573060182 0.999895975781355 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 2.28030160110266 0.155688368476676 145 2512 False False 0 0 1.64266120859479 0 0 0.000355731413006942 0.999679651460789 0.999252573060182 0.999895975781355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 5 7736 11869 0 0 0.000476732171726368 0.999578911908371 0.999017596768841 0.999863260157969 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 2.32493416188502 0.158592168532284 136.5 2071 False False 0 0 0 0 0 0 0 0 0 1.67480496260254 0 0 0.000476732171726368 0.999578911908371 0.999017596768841 0.999863260157969 5 3) Uncertain significance No change no 1 +Streptomycin rpsL c.-189T>A rpsL_c.-189T>A 1 upstream_gene_variant 781371 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rpsL c.-191G>A rpsL_c.-191G>A 1 upstream_gene_variant 781369 1 3 0 3 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.6429945931141 0.280491932584249 243 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.71438150990605 0.283358886007265 193.5 2071 False False 0 0 0 0 0 0 0 0 0 3.71438150990605 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 NA 3) Uncertain significance No change no 1 +Streptomycin rpsL c.192G>A rpsL_c.192G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin rpsL c.195G>A rpsL_c.195G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin rpsL c.198C>T rpsL_c.198C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin rpsL c.-19C>A rpsL_c.-19C>A 1 upstream_gene_variant 781541 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1433 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1176 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rpsL c.-19C>T rpsL_c.-19C>T 1 upstream_gene_variant 781541 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rpsL c.-204C>T rpsL_c.-204C>T 1 upstream_gene_variant 781356 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rpsL c.207C>T rpsL_c.207C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin rpsL c.-208C>T rpsL_c.-208C>T 1 upstream_gene_variant 781352 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rpsL c.-20C>T rpsL_c.-20C>T 1 upstream_gene_variant 781540 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rpsL c.-211A>C rpsL_c.-211A>C 1 upstream_gene_variant 781349 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rpsL c.213C>T rpsL_c.213C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin rpsL c.-223C>T rpsL_c.-223C>T 1 upstream_gene_variant 781337 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rpsL c.228G>A rpsL_c.228G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin rpsL c.-233delG rpsL_c.-233delG 1 upstream_gene_variant 781326 1 1 0 1 2 1 10366 15607 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999935930292158 0.99964307871082 0.999998377896754 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 58.6690617185945 1 973.5 2512 False False 3.01119043025274 0.156729426968348 177.474331043773 0 0 0.000355800035063835 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 59.8138891519084 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 4 3) Uncertain significance No change no 1 +Streptomycin rpsL c.241C>T rpsL_c.241C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 7 10368 15601 0 0 0.000355731413006942 0.999551512045105 0.999076163117038 0.999819666176692 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.04426933597617 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 7 7736 11867 0 0 0.000476732171726368 0.999410476671719 0.998785736251934 0.999762949244471 0 0 0.409616397225003 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.06467742986826 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin rpsL c.24C>T rpsL_c.24C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin rpsL c.-25A>T rpsL_c.-25A>T 1 upstream_gene_variant 781535 0 0 0 0 3 0 10365 15608 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 1 0.99976368249849 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1435 2512 False False Inf 0.622129167636411 Inf 0 0 0.000355834356021348 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 7733 11874 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 1 0.999689379610589 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1178 2071 False False 0 0 0 0 0 0 0 Inf 0.634338273987677 Inf 0 0 0.000476917074793532 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rpsL c.267C>T rpsL_c.267C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin rpsL c.276T>C rpsL_c.276T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.17274275317631 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin rpsL c.297C>T rpsL_c.297C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin rpsL c.300T>C rpsL_c.300T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.17274275317631 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin rpsL c.306G>A rpsL_c.306G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.17274275317631 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin rpsL c.315G>A rpsL_c.315G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin rpsL c.-31C>T rpsL_c.-31C>T 1 upstream_gene_variant 781529 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1445 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1187 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rpsL c.345C>T rpsL_c.345C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin rpsL c.372C>T rpsL_c.372C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin rpsL c.39G>A rpsL_c.39G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 10368 15604 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.28044779470556 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.71438150990605 NA NA NA NA NA NA 12 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin rpsL c.-45G>A rpsL_c.-45G>A 1 upstream_gene_variant 781515 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1447 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1188 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rpsL c.-54C>T rpsL_c.-54C>T 1 upstream_gene_variant 781506 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rpsL c.-58G>T rpsL_c.-58G>T 1 upstream_gene_variant 781502 1 7 0 7 2 7 10366 15601 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999551512045105 0.999076163117038 0.999819666176692 0.222222222222222 0.0281449734778982 0.600093573716312 0 0 0.409616397225003 0 0 0.409616397225003 0 0 1.04447166463163 0.0468719764352164 102 2512 False False 0.430004685648135 0.0435795940165012 2.25913666217328 0 0 0.000355800035063835 0.999551512045105 0.999076163117038 0.999819666176692 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 2 5 7734 11869 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999578911908371 0.999017596768841 0.999863260157969 0.285714285714285 0.0366925661760855 0.709579136262657 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.67523805433267 0.164214505965098 154.5 2071 False False 0 0 0 0 0 0 0 0.61386087406258 0.0584192274045222 3.75047184857656 0 0 0.000476855424503066 0.999578911908371 0.999017596768841 0.999863260157969 5 3) Uncertain significance No change no 1 +Streptomycin rpsL c.69T>C rpsL_c.69T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin rpsL c.72G>A rpsL_c.72G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin rpsL c.-77C>T rpsL_c.-77C>T 1 upstream_gene_variant 781483 1 1 0 1 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 58.6540000158548 1 973.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1177 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance No change no 1 +Streptomycin rpsL c.-79C>A rpsL_c.-79C>A 1 upstream_gene_variant 781481 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin rpsL c.-7delC rpsL_c.-7delC 1 upstream_gene_variant 781552 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1430 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1174 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rpsL c.-80_-77delACAC rpsL_c.-80_-77delACAC 1 upstream_gene_variant 781479 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1418 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin rpsL c.84G>T rpsL_c.84G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin rpsL c.87G>A rpsL_c.87G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.752676762805054 0.0127620362920002 14.460605698152 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin rpsL c.-91C>T rpsL_c.-91C>T 1 upstream_gene_variant 781469 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1426 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1169 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance No change no 1 +Streptomycin rpsL c.-94A>T rpsL_c.-94A>T 1 upstream_gene_variant 781466 1 3 0 3 1 4 10367 15604 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999743721168631 0.999343955596995 0.999930168370675 0.2 0.00505076337946806 0.716417936118089 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.64311258444586 0.280496630841219 256 2512 False False 0.376290151442075 0.00764455959995544 3.80334957923739 0 0 0.000355765720726338 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Streptomycin rpsL c.99A>C rpsL_c.99A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin rpsL c.9C>T rpsL_c.9C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 42 10368 15566 0 0 0.000355731413006942 0.99730907227063 0.996364369242586 0.998059948726648 0 0 0.0840838549403552 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 0 0.137863356429157 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 0 38 7736 11836 0 0 0.000476732171726368 0.996799730503621 0.995609999809685 0.997734333730646 0 0 0.0925127614158782 NA NA NA NA NA NA NA NA NA NA NA NA False True 1 1 1 0 0 0 0 0 0 0.156046470965314 NA NA NA NA NA NA 43 5) Not assoc w R Now listed Silent mutation no 0 +Streptomycin rpsL LoF rpsL_LoF 1 LoF (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2511 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2071 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rpsL p.Ala113Gly rpsL_p.Ala113Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin rpsL p.Arg114Cys rpsL_p.Arg114Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1415 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1160 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rpsL p.Arg116His rpsL_p.Arg116His 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rpsL p.Arg30Cys rpsL_p.Arg30Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1441 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1183 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rpsL p.Arg86Gln rpsL_p.Arg86Gln 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 5 0 10363 15608 0.000482253086419753 0.000156604214122162 0.00112505595550109 1 0.99976368249849 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 1423 2512 False False Inf 1.37979907306709 Inf 0 0 0.000355903017804084 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 5 0 7731 11874 0.000646328852119958 0.0002098934625097 0.00150766595359595 1 0.999689379610589 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 1166 2071 False False 0 0 0 0 0 0 0 Inf 1.40693962335604 Inf 0 0 0.000477040423209609 1 0.999689379610589 1 1 3) Uncertain significance No change no 1 +Streptomycin rpsL p.Arg86Gly rpsL_p.Arg86Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 3 3) Uncertain significance New Uncertain no 0 +Streptomycin rpsL p.Arg94Cys rpsL_p.Arg94Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1443 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1185 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 2 3) Uncertain significance New Uncertain no 0 +Streptomycin rpsL p.Asn73Lys rpsL_p.Asn73Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rpsL p.Asp14Glu rpsL_p.Asp14Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rpsL p.Asp14Tyr rpsL_p.Asp14Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1429 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1173 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rpsL p.Gln105Glu rpsL_p.Gln105Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin rpsL p.Glu122Lys rpsL_p.Glu122Lys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1442 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1184 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance No change no 1 +Streptomycin rpsL p.Glu70Ala rpsL_p.Glu70Ala 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 0 1 3 2 10365 15606 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999871860584315 0.999537193839207 0.999984481345552 0.6 0.146632799634673 0.947255049473683 0 0 0.975 0 0 0.841886116991581 0 0 58.6709610085939 1 973.5 2512 False False 2.25846599131693 0.258657968313028 27.0476864113414 0 0 0.000355834356021348 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 1 7734 11873 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999915782381674 0.999530859783396 0.999997867796783 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 1170 2071 False False 0 0 0 0 0 0 0 3.07033876389966 0.159799628612092 180.959738606129 0 0 0.000476855424503066 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance No change no 1 +Streptomycin rpsL p.Glu76Ala rpsL_p.Glu76Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin rpsL p.Gly100Ser rpsL_p.Gly100Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rpsL p.Gly106Cys rpsL_p.Gly106Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1455 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin rpsL p.Gly124Ser rpsL_p.Gly124Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 7 10368 15601 0 0 0.000355731413006942 0.999551512045105 0.999076163117038 0.999819666176692 0 0 0.409616397225003 0 0 0.975 0 0 0.409616397225003 0 0 58.635226304487 1 973.5 2512 False False 0 0 1.04426933597617 0 0 0.000355731413006942 0.999551512045105 0.999076163117038 0.999819666176692 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 7 7736 11867 0 0 0.000476732171726368 0.999410476671719 0.998785736251934 0.999762949244471 0 0 0.409616397225003 0 0 0.975 0 0 0.409616397225003 0 0 59.7759723181037 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 1.06467742986826 0 0 0.000476732171726368 0.999410476671719 0.998785736251934 0.999762949244471 5 3) Uncertain significance No change no 1 +Streptomycin rpsL p.Gly71Asp rpsL_p.Gly71Asp 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1431 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Streptomycin rpsL p.Gly71Ser rpsL_p.Gly71Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1427 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1171 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rpsL p.Ile16Thr rpsL_p.Ile16Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1416 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin rpsL p.Ile16Val rpsL_p.Ile16Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 10368 15604 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 8.01462049278838 0.520315555582948 435.5 2512 False False 0 0 2.28044779470556 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 59.7961004349848 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 3.71438150990605 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 2 3) Uncertain significance No change no 1 +Streptomycin rpsL p.Lys108Thr rpsL_p.Lys108Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rpsL p.Lys10Thr rpsL_p.Lys10Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1452 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1193 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rpsL p.Lys123* rpsL_p.Lys123* 1 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1444 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1186 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rpsL p.Lys43Arg rpsL_p.Lys43Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 3489 3409 80 4715 100 5653 15508 0.454764660493827 0.445145408799694 0.464409332438263 0.993593029215786 0.99221281155912 0.994784081721957 0.979231568016614 0.974796953008453 0.983070823393393 0.97707079392376 0.971542936765736 0.981777707232037 0.971501852379595 0.965445956001709 0.976753969024563 116.899814257916 93.2799100215062 147.84804796462 0 1.5 2512 True False 129.347638422076 105.931841692847 159.616514547818 0.37618627234606 0.366198328122016 0.38625387245747 0.993593029215786 0.99221281155912 0.994784081721957 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 2751 2692 59 3712 73 4024 11801 0.479834539813857 0.468646422080033 0.49103785982289 0.99385211386222 0.992276077125479 0.995178033549836 0.980713342140026 0.975810287223267 0.984852636339118 0.978553253362413 0.972421537193726 0.983634631134487 0.973598553345388 0.966917387057716 0.979249690135154 133.808555446979 103.305775695528 176.749786010104 0 1.5 2071 True False 0 0 0 0 0 0 0 149.123451074375 117.848737406078 191.999575762945 0.400833829660512 0.389083998812244 0.412669832838496 0.99385211386222 0.992276077125479 0.995178033549836 4643 Assoc w R Assoc w R 1) Assoc w R No change yes 1 +Streptomycin rpsL p.Lys43Asn rpsL_p.Lys43Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1422 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1165 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance No change no 1 +Streptomycin rpsL p.Lys43Met rpsL_p.Lys43Met 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 1 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0386035211949905 Inf 0.399114533205004 308.5 2512 False False Inf 0.282736080598822 Inf 9.64599209028648e-05 2.44215077354346e-06 0.000537321795461189 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0393613144801391 Inf 0.394461726758121 237.5 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0.000129282482223658 3.27314370392442e-06 0.000720103058325324 1 0.999689379610589 1 NA 3) Uncertain significance No change no 1 +Streptomycin rpsL p.Lys43Thr rpsL_p.Lys43Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 3 1 10365 15607 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999935930292158 0.99964307871082 0.999998377896754 0.75 0.194120449683243 0.99369053679029 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0386047717076459 Inf 0.399106764717206 300 2512 False False 4.51722141823444 0.362625225225282 236.854590713406 9.64692263168049e-05 2.44238636565143e-06 0.000537373619049235 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 3 0 7733 11874 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 1 0.999689379610589 1 1 0.292401773821286 1 1 0.025 1 1 0.025 1 Inf 0.0393664039281761 Inf 0.394430844553243 227 2071 False False 0 0 0 0 0 0 0 Inf 0.634338273987677 Inf 0.00012929919834497 3.27356691808869e-06 0.000720196139555935 1 0.999689379610589 1 3 3) Uncertain significance No change no 1 +Streptomycin rpsL p.Lys88Arg rpsL_p.Lys88Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1013 991 22 1280 29 9088 15579 0.123456790123456 0.117182900361072 0.129942996306488 0.998141978472578 0.997332652594423 0.998755311644571 0.977845683728036 0.968336747753611 0.985113899992361 0.978282329713721 0.96730297300251 0.986340803966078 0.97156862745098 0.95942165498331 0.980878167133379 77.2186549695902 50.7289803094988 123.556337697121 0 1.5 2512 True False 75.6629431762991 52.3707720003456 113.457472786527 0.0983232463538049 0.0925773986569885 0.104302353910706 0.998141978472578 0.997332652594423 0.998755311644571 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 871 857 14 1095 18 6641 11856 0.14154601861427 0.133849710242672 0.149513445068631 0.998484082870136 0.997605251464505 0.999101331744648 0.983827493261455 0.974560511507319 0.990387714361415 0.983926521239954 0.973178363667841 0.991185341553644 0.979428571428571 0.967682540607095 0.987763606392938 109.284229999784 64.6524582873449 201.835015690645 0 1.5 2071 True False 0 0 0 0 0 0 0 108.604125884655 68.4390549946914 184.830298039466 0.114297145905574 0.107179676336217 0.121715968743351 0.998484082870136 0.997605251464505 0.999101331744648 737 Assoc w R Assoc w R 1) Assoc w R No change yes 1 +Streptomycin rpsL p.Lys88Gln rpsL_p.Lys88Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 9 6 3 15 4 10353 15604 0.00144675925925925 0.00080995915704588 0.00238508849276012 0.999743721168631 0.999343955596995 0.999930168370675 0.789473684210526 0.544346918108494 0.93947546229071 0.666666666666666 0.29929505620854 0.925145368580308 0.6 0.262378076606945 0.878447741880172 3.01439196368202 0.643571278957003 18.630205868506 0.169506758609763 204 2512 False False 5.65198493190379 1.79979362259667 23.3998993672543 0.000579206487112655 0.000212587286939222 0.00126025915148948 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 4 2 10 3 7726 11871 0.00129265770423991 0.000620048157733657 0.00237595446225449 0.999747347145022 0.999261820436506 0.999947893876346 0.769230769230769 0.461868460765959 0.949618926508848 0.666666666666666 0.222778095503512 0.956728131707258 0.571428571428571 0.184051567640083 0.901011721557492 3.07300025886616 0.440267288053636 33.9823035382636 0.220757112062422 166 2071 False False 0 0 0 0 0 0 0 5.12166709811027 1.31809017901265 28.9886302790483 0.000517464424320828 0.000141009063241455 0.00132437962805983 0.999747347145022 0.999261820436506 0.999947893876346 7 Assoc w R Assoc w RI Previous WHO guidance 2) Assoc w R - Interim No change yes Prev. WHO 1 +Streptomycin rpsL p.Lys88Met rpsL_p.Lys88Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 23 23 0 31 0 10337 15608 0.00298996913580246 0.00203241547020309 0.00424136062971118 1 0.99976368249849 1 1 0.88781125307763 1 1 0.851814871084775 1 1 0.851814871084775 1 Inf 8.67620278382042 Inf 6.52841479728172e-10 14 2512 True False Inf 11.946264374388 Inf 0.00222007722007722 0.00140784290697681 0.00332935489592016 1 0.99976368249849 1 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 19 19 0 26 0 7710 11874 0.00336091003102378 0.0021965968588793 0.0049206608623853 1 0.999689379610589 1 1 0.867725395502245 1 1 0.823533088193034 1 1 0.823533088193034 1 Inf 7.18435051270954 Inf 2.06247162064744e-08 10 2071 True False 0 0 0 0 0 0 0 Inf 10.0969405560714 Inf 0.0024582740328632398 0.0014806703009084 0.00383624906486583 1 0.999689379610589 1 31 Assoc w R 1) Assoc w R No change yes 1 +Streptomycin rpsL p.Lys88Thr rpsL_p.Lys88Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 6 0 71 1 10297 15607 0.00684799382716049 0.00535210080604707 0.00863007417772077 0.999935930292158 0.99964307871082 0.999998377896754 0.986111111111111 0.92502868914608 0.999648425594766 1 0.540741873560099 1 0.857142857142857 0.421276802956804 0.996389703138099 Inf 1.78409950220898 Inf 0.0039499970164048 52 2512 False False 107.613576769933 18.6941363325504 4207.32350106203 0.000582354653984276 0.000213742921725339 0.00126710670371275 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 3 0 10 0 7726 11874 0.00129265770423991 0.000620048157733657 0.00237595446225449 1 0.999689379610589 1 1 0.691502892181239 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.634912866648028 Inf 0.0612773787794145 88 2071 False False 0 0 0 0 0 0 0 Inf 3.44347270676645 Inf 0.000388148531504722 8.00527126502773e-05 0.00113391157892271 1 0.999689379610589 1 55 3) Uncertain significance No change no 1 +Streptomycin rpsL p.Pro2Arg rpsL_p.Pro2Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin rpsL p.Pro2Ser rpsL_p.Pro2Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1449 2512 False False Inf 0.282736080598822 Inf 0 0 0.000355800035063835 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1190 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0 0 0.000476855424503066 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rpsL p.Pro91Ser rpsL_p.Pro91Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1438 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1180 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance No change no 1 +Streptomycin rpsL p.Ser101Ala rpsL_p.Ser101Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1424 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1167 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rpsL p.Ser17Arg rpsL_p.Ser17Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance No change no 1 +Streptomycin rpsL p.Ser17Asn rpsL_p.Ser17Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 10368 15604 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.28044779470556 0.155697794255122 153.5 2512 False False 0 0 2.28044779470556 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 3 3) Uncertain significance No change no 1 +Streptomycin rpsL p.Ser17Ile rpsL_p.Ser17Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1439 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1181 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rpsL p.Thr104Met rpsL_p.Thr104Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rpsL p.Thr35Ala rpsL_p.Thr35Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin rpsL p.Thr40Ile rpsL_p.Thr40Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1453 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1194 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rpsL p.Thr58Ala rpsL_p.Thr58Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin rpsL p.Thr64Met rpsL_p.Thr64Met 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1456 2512 False False Inf 0.282736080598822 Inf 0 0 0.000355800035063835 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1196 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance No change no 1 +Streptomycin rpsL p.Val107Ala rpsL_p.Val107Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1434 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin rpsL p.Val55Met rpsL_p.Val55Met 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin rpsL p.Val63Ile rpsL_p.Val63Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1457 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1197 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.1000G>A rrs_n.1000G>A 1 non_coding_transcript_exon_variant 1472845 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1788 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1479 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1001C>A rrs_n.1001C>A 1 non_coding_transcript_exon_variant 1472846 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1776 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1469 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1001C>G rrs_n.1001C>G 1 non_coding_transcript_exon_variant 1472846 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.1002G>T rrs_n.1002G>T 1 non_coding_transcript_exon_variant 1472847 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1937 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1612 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1003T>C rrs_n.1003T>C 1 non_coding_transcript_exon_variant 1472848 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2108 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1760 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1005T>C rrs_n.1005T>C 1 non_coding_transcript_exon_variant 1472850 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1763 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1457 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance No change no 1 +Streptomycin rrs n.1008A>C rrs_n.1008A>C 1 non_coding_transcript_exon_variant 1472853 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2149 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1796 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 3 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1009G>A rrs_n.1009G>A 1 non_coding_transcript_exon_variant 1472854 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.-101_-100insG rrs_n.-101_-100insG 1 upstream_gene_variant 1471745 1 2 1 1 5 1 10363 15607 0.000482253086419753 0.000156604214122162 0.00112505595550109 0.999935930292158 0.99964307871082 0.999998377896754 0.833333333333333 0.358765421002325 0.99578925548551 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.50603107208337 0.0191911390984394 118.120229263927 1 610 2512 False False 7.53015536041686 0.842353453161053 355.554202953959 9.6487842531841e-05 2.44285768625785e-06 0.000537477296220785 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 4 1 7732 11873 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.999915782381674 0.999530859783396 0.999997867796783 0.8 0.28358206388191 0.994949236620532 0 0 0.975 0 0 0.975 0 0 59.8370751190188 1 806.5 2071 False False 0 0 0 0 0 0 0 6.14226590791515 0.607630898004113 302.048561734113 0 0 0.000476978741026985 0.999915782381674 0.999530859783396 0.999997867796783 4 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1011dupT rrs_n.1011dupT 1 non_coding_transcript_exon_variant 1472855 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1012A>C rrs_n.1012A>C 1 non_coding_transcript_exon_variant 1472857 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1764 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1458 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1012A>G rrs_n.1012A>G 1 non_coding_transcript_exon_variant 1472857 1 6 0 6 3 14 10365 15594 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.99910302409021 0.99849548434986 0.999509530910458 0.176470588235294 0.0379850680706259 0.434317872844283 0 0 0.4592581264399 0 0 0.231635761650116 0 0 1.27809563119186 0.0875874696735635 125 2512 False False 0.322389911101922 0.0593965121168808 1.15551875549308 0 0 0.000355834356021348 0.99910302409021 0.99849548434986 0.999509530910458 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 3 13 7733 11861 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 0.998905170961765 0.998128536682641 0.999416924941029 0.1875 0.0404737339059459 0.456456546231611 0 0 0.4592581264399 0 0 0.24705263800047 0 0 1.30311872824255 0.0877154606483815 108 2071 False False 0 0 0 0 0 0 0 0.35395756448388 0.0646768735985669 1.28869710429076 0 0 0.000476917074793532 0.998905170961765 0.998128536682641 0.999416924941029 6 3) Uncertain significance No change no 1 +Streptomycin rrs n.1013G>T rrs_n.1013G>T 1 non_coding_transcript_exon_variant 1472858 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 3 3) Uncertain significance No change no 1 +Streptomycin rrs n.1014_1015insA rrs_n.1014_1015insA 1 non_coding_transcript_exon_variant 1472859 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2032 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1693 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1016G>C rrs_n.1016G>C 1 non_coding_transcript_exon_variant 1472861 1 1 0 1 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 58.6502452744631 1 973.5 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Streptomycin rrs n.1016G>T rrs_n.1016G>T 1 non_coding_transcript_exon_variant 1472861 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1695 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Streptomycin rrs n.1018T>C rrs_n.1018T>C 1 non_coding_transcript_exon_variant 1472863 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1911 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1590 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1021C>T rrs_n.1021C>T 1 non_coding_transcript_exon_variant 1472866 1 3 0 3 2 4 10366 15604 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999743721168631 0.999343955596995 0.999930168370675 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.6434640919271 0.280510633342664 264 2512 False False 0.752652903723712 0.0680519547847045 5.25297485318028 0 0 0.000355800035063835 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 2 3 7734 11871 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999747347145022 0.999261820436506 0.999947893876346 0.4 0.0527449505263169 0.853367200365326 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.71534223844124 0.283397993335255 208 2071 False False 0 0 0 0 0 0 0 1.02327385570209 0.0854221600622099 8.93608975066686 0 0 0.000476855424503066 0.999747347145022 0.999261820436506 0.999947893876346 10 3) Uncertain significance No change no 1 +Streptomycin rrs n.1022_1032delTTGTGGCCTGTinsCTTCGGGGGACAAA rrs_n.1022_1032delTTGTGGCCTGTinsCTTCGGGGGACAAA 1 non_coding_transcript_exon_variant 1472867 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1715 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1022_1032delTTGTGGCCTGTinsCTTCGGGGGCAGA rrs_n.1022_1032delTTGTGGCCTGTinsCTTCGGGGGCAGA 1 non_coding_transcript_exon_variant 1472867 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1852 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1022T>G rrs_n.1022T>G 1 non_coding_transcript_exon_variant 1472867 0 0 0 0 9 0 10359 15608 0.000868055555555555 0.000397004661559041 0.00164719739830421 1 0.99976368249849 1 1 0.663732883120057 1 NA NA NA NA NA NA NA NA NA NA 1734 2512 False False Inf 2.97305673502534 Inf 0 0 0.000356040420894094 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 9 0 7727 11874 0.00116339193381592 0.000532110502771461 0.00220732634615895 1 0.999689379610589 1 1 0.663732883120057 1 NA NA NA NA NA NA NA NA NA NA 1432 2071 False False 0 0 0 0 0 0 0 Inf 3.03189582764095 Inf 0 0 0.00047728731155563 1 0.999689379610589 1 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.1024_1032delGTGGCCTGTinsCGGGGGCAGA rrs_n.1024_1032delGTGGCCTGTinsCGGGGGCAGA 1 non_coding_transcript_exon_variant 1472869 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1765 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1459 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1025T>C rrs_n.1025T>C 1 non_coding_transcript_exon_variant 1472870 1 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2095 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1749 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.1027G>A rrs_n.1027G>A 1 non_coding_transcript_exon_variant 1472872 1 3 0 3 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.6429945931141 0.280491932584249 243 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.71438150990605 0.283358886007265 193.5 2071 False False 0 0 0 0 0 0 0 0 0 3.71438150990605 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1028C>T rrs_n.1028C>T 1 non_coding_transcript_exon_variant 1472873 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1789 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1480 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 2 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1030T>G rrs_n.1030T>G 1 non_coding_transcript_exon_variant 1472875 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1938 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1613 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 5 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1031G>T rrs_n.1031G>T 1 non_coding_transcript_exon_variant 1472876 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.1034T>C rrs_n.1034T>C 1 non_coding_transcript_exon_variant 1472879 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2016 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1677 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1035_1036insA rrs_n.1035_1036insA 1 non_coding_transcript_exon_variant 1472880 1 0 0 0 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1984 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1651 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1035G>A rrs_n.1035G>A 1 non_coding_transcript_exon_variant 1472880 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2081 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1736 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 4 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1037A>G rrs_n.1037A>G 1 non_coding_transcript_exon_variant 1472882 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1912 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1591 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.-103T>A rrs_n.-103T>A 1 upstream_gene_variant 1471743 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1894 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1575 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1042G>C rrs_n.1042G>C 1 non_coding_transcript_exon_variant 1472887 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2033 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1694 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 13 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1050C>T rrs_n.1050C>T 1 non_coding_transcript_exon_variant 1472895 0 0 0 0 13 33 10355 15575 0.00125385802469135 0.000667790166179422 0.00214318097672708 0.997885699641209 0.997032005789816 0.998544179730394 0.282608695652173 0.159866701924902 0.43460407778425 NA NA NA 0 0 0.105762810074579 NA NA NA NA 2064 2512 False False 0.592525935355486 0.286057657076763 1.15681633546375 0 0 0.000356177930119202 0.997885699641209 0.997032005789816 0.998544179730394 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 10 28 7726 11846 0.00129265770423991 0.000620048157733657 0.00237595446225449 0.997641906686878 0.996593688246593 0.998432509782957 0.263157894736842 0.134033723024973 0.431008243702239 NA NA NA 0 0 0.123436118500263 NA NA NA NA 1721 2071 False False 0 0 0 0 0 0 0 0.547594393698457 0.237184908845198 1.16228056848215 0 0 0.000477349073576999 0.997641906686878 0.996593688246593 0.998432509782957 294 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1058A>G rrs_n.1058A>G 1 non_coding_transcript_exon_variant 1472903 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1866 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.1062C>T rrs_n.1062C>T 1 non_coding_transcript_exon_variant 1472907 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2034 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.1064T>C rrs_n.1064T>C 1 non_coding_transcript_exon_variant 1472909 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1913 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1067C>T rrs_n.1067C>T 1 non_coding_transcript_exon_variant 1472912 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2127 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1072G>A rrs_n.1072G>A 1 non_coding_transcript_exon_variant 1472917 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2109 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1077dupT rrs_n.1077dupT 1 non_coding_transcript_exon_variant 1472920 0 0 0 0 3 0 10365 15608 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 1 0.99976368249849 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2065 2512 False False Inf 0.622129167636411 Inf 0 0 0.000355834356021348 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 7733 11874 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 1 0.999689379610589 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1722 2071 False False 0 0 0 0 0 0 0 Inf 0.634338273987677 Inf 0 0 0.000476917074793532 1 0.999689379610589 1 2 3) Uncertain significance No change no 1 +Streptomycin rrs n.1078G>A rrs_n.1078G>A 1 non_coding_transcript_exon_variant 1472923 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1939 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1614 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1079G>A rrs_n.1079G>A 1 non_coding_transcript_exon_variant 1472924 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Streptomycin rrs n.1089C>T rrs_n.1089C>T 1 non_coding_transcript_exon_variant 1472934 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1790 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1481 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1089dupC rrs_n.1089dupC 1 non_coding_transcript_exon_variant 1472931 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1926 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1602 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1091C>G rrs_n.1091C>G 1 non_coding_transcript_exon_variant 1472936 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2035 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1695 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.1098C>A rrs_n.1098C>A 1 non_coding_transcript_exon_variant 1472943 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2110 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1761 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1099G>A rrs_n.1099G>A 1 non_coding_transcript_exon_variant 1472944 1 3 0 3 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.6429945931141 0.280491932584249 243 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.1105C>G rrs_n.1105C>G 1 non_coding_transcript_exon_variant 1472950 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1914 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1592 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1107_1118dupTGTCTCATGTTG rrs_n.1107_1118dupTGTCTCATGTTG 1 non_coding_transcript_exon_variant 1472951 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1955 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1107T>C rrs_n.1107T>C 1 non_coding_transcript_exon_variant 1472952 1 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1985 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1652 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 59 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1108_1109insA rrs_n.1108_1109insA 1 non_coding_transcript_exon_variant 1472953 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1878 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1560 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1108G>A rrs_n.1108G>A 1 non_coding_transcript_exon_variant 1472953 0 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1766 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1460 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 4 3) Uncertain significance No change no 1 +Streptomycin rrs n.1108G>T rrs_n.1108G>T 1 non_coding_transcript_exon_variant 1472953 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.1109T>A rrs_n.1109T>A 1 non_coding_transcript_exon_variant 1472954 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2096 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1750 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1109T>C rrs_n.1109T>C 1 non_coding_transcript_exon_variant 1472954 1 3 0 3 1 3 10367 15605 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999807790876473 0.99943838714673 0.999960360103688 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.64334605529666 0.280505932748473 259.5 2512 False False 0.501752355229735 0.00956153582768186 6.25014259670444 0 0 0.000355765720726338 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17379939830658 0.52225229054203 453 2071 False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 0 0 0.000476793790149404 0.999831564763348 0.99939168785815 0.999979601060482 34 3) Uncertain significance No change no 1 +Streptomycin rrs n.1110C>T rrs_n.1110C>T 1 non_coding_transcript_exon_variant 1472955 1 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2128 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1778 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 62 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1111T>C rrs_n.1111T>C 1 non_coding_transcript_exon_variant 1472956 1 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1824 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1512 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 88 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1112_1114delCATinsTA rrs_n.1112_1114delCATinsTA 1 non_coding_transcript_exon_variant 1472957 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1867 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1550 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1112C>A rrs_n.1112C>A 1 non_coding_transcript_exon_variant 1472957 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1791 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Streptomycin rrs n.1112C>T rrs_n.1112C>T 1 non_coding_transcript_exon_variant 1472957 1 4 0 4 2 6 10366 15602 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999615581752947 0.999163472525571 0.999858912630967 0.25 0.0318540262499442 0.650855794412824 0 0 0.602364635616474 0 0 0.4592581264399 0 0 2.28059557533776 0.155707318892894 160 2512 False False 0.50170428966493 0.0495150381555913 2.80649490654312 0 0 0.000355800035063835 0.999615581752947 0.999163472525571 0.999858912630967 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 2 6 7734 11868 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999494694290045 0.998900489118281 0.999814539856352 0.25 0.0318540262499442 0.650855794412824 0 0 0.602364635616474 0 0 0.4592581264399 0 0 2.32533978434322 0.158618916434975 147 2071 False False 0 0 0 0 0 0 0 0.511507628652702 0.0504799102640932 2.8615766008904 0 0 0.000476855424503066 0.999494694290045 0.998900489118281 0.999814539856352 87 3) Uncertain significance No change no 1 +Streptomycin rrs n.1113A>T rrs_n.1113A>T 1 non_coding_transcript_exon_variant 1472958 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1696 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1401 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1114T>A rrs_n.1114T>A 1 non_coding_transcript_exon_variant 1472959 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1697 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1402 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1124A>G rrs_n.1124A>G 1 non_coding_transcript_exon_variant 1472969 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2017 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1678 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 6 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1125_1132delCGTAATGGinsTTCAGT rrs_n.1125_1132delCGTAATGGinsTTCAGT 1 non_coding_transcript_exon_variant 1472970 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2082 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1737 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1125C>A rrs_n.1125C>A 1 non_coding_transcript_exon_variant 1472970 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2139 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1787 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1126_1130delGTAATinsTTCG rrs_n.1126_1130delGTAATinsTTCG 1 non_coding_transcript_exon_variant 1472971 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1915 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1593 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1128A>G rrs_n.1128A>G 1 non_coding_transcript_exon_variant 1472973 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2018 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1679 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 41 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.-112G>T rrs_n.-112G>T 1 upstream_gene_variant 1471734 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.1133T>C rrs_n.1133T>C 1 non_coding_transcript_exon_variant 1472978 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1698 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1403 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 8 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1137G>C rrs_n.1137G>C 1 non_coding_transcript_exon_variant 1472982 0 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1839 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1527 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1138A>C rrs_n.1138A>C 1 non_coding_transcript_exon_variant 1472983 0 0 0 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2140 2512 False False Inf 0.282736080598822 Inf 0 0 0.000355800035063835 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1788 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0 0 0.000476855424503066 1 0.999689379610589 1 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1141C>T rrs_n.1141C>T 1 non_coding_transcript_exon_variant 1472986 1 7 1 6 3 6 10365 15602 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999615581752947 0.999163472525571 0.999858912630967 0.333333333333333 0.0748546314196918 0.700704943791459 0.142857142857142 0.00361029686190058 0.578723197043195 0.142857142857142 0.00361029686190058 0.578723197043195 0.25087634667953 0.00545785764865319 2.06842956101889 0.255134953802544 220 2512 False False 0.752629040038591 0.12178352858009 3.52509268945684 9.64692263168049e-05 2.44238636565143e-06 0.000537373619049235 0.999615581752947 0.999163472525571 0.999858912630967 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 3 3) Uncertain significance No change no 1 +Streptomycin rrs n.1142G>A rrs_n.1142G>A 1 non_coding_transcript_exon_variant 1472987 1 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1716 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1419 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 68 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1142G>T rrs_n.1142G>T 1 non_coding_transcript_exon_variant 1472987 0 0 0 0 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1916 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 0 0 0.000355765720726338 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1594 2071 False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 0 0 0.000476793790149404 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1143T>A rrs_n.1143T>A 1 non_coding_transcript_exon_variant 1472988 0 0 0 0 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1940 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 0 0 0.000355765720726338 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1615 2071 False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 0 0 0.000476793790149404 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1144G>A rrs_n.1144G>A 1 non_coding_transcript_exon_variant 1472989 1 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1717 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1420 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 57 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1145A>G rrs_n.1145A>G 1 non_coding_transcript_exon_variant 1472990 1 0 0 0 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1718 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1421 2071 False False 0 0 0 0 0 0 0 0 0 3.71438150990605 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 87 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1147A>T rrs_n.1147A>T 1 non_coding_transcript_exon_variant 1472992 0 0 0 0 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1879 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 0 0 0.000355765720726338 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1561 2071 False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 0 0 0.000476793790149404 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1148_1149dupGA rrs_n.1148_1149dupGA 1 non_coding_transcript_exon_variant 1472988 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1927 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1603 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1148G>A rrs_n.1148G>A 1 non_coding_transcript_exon_variant 1472993 1 11 0 11 6 11 10362 15597 0.000578703703703703 0.000212402724453782 0.00125916554902567 0.999295233213736 0.998739328260189 0.999648132128855 0.352941176470588 0.14209748311022 0.616716336556597 0 0 0.284914152918154 0 0 0.284914152918154 0 0 0.599903715819619 0.00440515297995994 57 2512 False False 0.821024372269305 0.249233335641071 2.42287371216559 0 0 0.000355937358633142 0.999295233213736 0.998739328260189 0.999648132128855 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 11 0 11 6 11 7730 11863 0.00077559462254395 0.000284681048736677 0.00168737281383633 0.999073606198416 0.998343031567643 0.999537459717592 0.352941176470588 0.14209748311022 0.616716336556597 0 0 0.284914152918154 0 0 0.284914152918154 0 0 0.611717426842948 0.00465692187669261 48 2071 False False 0 0 0 0 0 0 0 0.837092790779724 0.254085324765121 2.4706054422472 0 0 0.000477102121347592 0.999073606198416 0.998343031567643 0.999537459717592 5 3) Uncertain significance No change no 1 +Streptomycin rrs n.1151T>C rrs_n.1151T>C 1 non_coding_transcript_exon_variant 1472996 1 5 0 5 2 5 10366 15603 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999679651460789 0.999252573060182 0.999895975781355 0.285714285714285 0.0366925661760855 0.709579136262657 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.64297814081651 0.164653924536377 193 2512 False False 0.602083735288443 0.0572994001432256 3.67859568857157 0 0 0.000355800035063835 0.999679651460789 0.999252573060182 0.999895975781355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 2 5 7734 11869 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999578911908371 0.999017596768841 0.999863260157969 0.285714285714285 0.0366925661760855 0.709579136262657 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.67523805433267 0.164214505965098 154.5 2071 False False 0 0 0 0 0 0 0 0.61386087406258 0.0584192274045222 3.75047184857656 0 0 0.000476855424503066 0.999578911908371 0.999017596768841 0.999863260157969 9 3) Uncertain significance No change no 1 +Streptomycin rrs n.1153C>T rrs_n.1153C>T 1 non_coding_transcript_exon_variant 1472998 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance No change no 1 +Streptomycin rrs n.1157G>T rrs_n.1157G>T 1 non_coding_transcript_exon_variant 1473002 0 0 0 0 4 2 10364 15606 0.000385802469135802 0.000105127872737001 0.000987510251175401 0.999871860584315 0.999537193839207 0.999984481345552 0.666666666666666 0.222778095503512 0.956728131707258 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1968 2512 False False 3.01157854110382 0.43150328206235 33.3041852472562 0 0 0.000355868683600791 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 2 7732 11872 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.999831564763348 0.99939168785815 0.999979601060482 0.666666666666666 0.222778095503512 0.956728131707258 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1637 2071 False False 0 0 0 0 0 0 0 3.07087428867046 0.439962791152193 33.9588674822466 0 0 0.000476978741026985 0.999831564763348 0.99939168785815 0.999979601060482 3 3) Uncertain significance No change no 1 +Streptomycin rrs n.1159T>A rrs_n.1159T>A 1 non_coding_transcript_exon_variant 1473004 0 0 0 0 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1880 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 0 0 0.000355765720726338 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1562 2071 False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 0 0 0.000476793790149404 0.999831564763348 0.99939168785815 0.999979601060482 3 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1160C>G rrs_n.1160C>G 1 non_coding_transcript_exon_variant 1473005 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.1163C>A rrs_n.1163C>A 1 non_coding_transcript_exon_variant 1473008 0 0 0 0 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1804 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 0 0 0.000355765720726338 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1492 2071 False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 0 0 0.000476793790149404 0.999831564763348 0.99939168785815 0.999979601060482 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1164T>A rrs_n.1164T>A 1 non_coding_transcript_exon_variant 1473009 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Streptomycin rrs n.1164T>C rrs_n.1164T>C 1 non_coding_transcript_exon_variant 1473009 0 0 0 0 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2150 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 0 0 0.000355765720726338 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1797 2071 False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 0 0 0.000476793790149404 0.999831564763348 0.99939168785815 0.999979601060482 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1166G>A rrs_n.1166G>A 1 non_coding_transcript_exon_variant 1473011 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1175dupT rrs_n.1175dupT 1 non_coding_transcript_exon_variant 1473019 0 0 0 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1735 2512 False False Inf 0.282736080598822 Inf 0 0 0.000355800035063835 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1433 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0 0 0.000476855424503066 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1175T>C rrs_n.1175T>C 1 non_coding_transcript_exon_variant 1473020 0 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1917 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1595 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1176G>A rrs_n.1176G>A 1 non_coding_transcript_exon_variant 1473021 1 0 0 0 0 4 10368 15604 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1699 2512 False False 0 0 2.28044779470556 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1404 2071 False False 0 0 0 0 0 0 0 0 0 3.71438150990605 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 8 3) Uncertain significance No change no 1 +Streptomycin rrs n.-117delT rrs_n.-117delT 1 upstream_gene_variant 1471728 1 1 0 1 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 58.6540000158548 1 973.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 59.801132462225 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 5 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.-118_-117insT rrs_n.-118_-117insT 1 upstream_gene_variant 1471728 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.1180A>G rrs_n.1180A>G 1 non_coding_transcript_exon_variant 1473025 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1750 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1181T>C rrs_n.1181T>C 1 non_coding_transcript_exon_variant 1473026 0 0 0 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2141 2512 False False Inf 0.282736080598822 Inf 0 0 0.000355800035063835 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1789 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0 0 0.000476855424503066 1 0.999689379610589 1 5 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.-118A>C rrs_n.-118A>C 1 upstream_gene_variant 1471728 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance No change no 1 +Streptomycin rrs n.1190G>A rrs_n.1190G>A 1 non_coding_transcript_exon_variant 1473035 0 0 0 0 12 33 10356 15575 0.0011574074074074 0.000598187780713703 0.00202088408121616 0.997885699641209 0.997032005789816 0.998544179730394 0.266666666666666 0.146040715838129 0.419446704742017 NA NA NA 0 0 0.105762810074579 NA NA NA NA 1881 2512 False False 0.546894202745883 0.257076509639911 1.08724493279189 0 0 0.000356143542856035 0.997885699641209 0.997032005789816 0.998544179730394 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 10 31 7726 11843 0.00129265770423991 0.000620048157733657 0.00237595446225449 0.997389253831901 0.996296283622464 0.998225456465932 0.24390243902439 0.123632488395844 0.40304623662365 NA NA NA 0 0 0.11218874692237 NA NA NA NA 1563 2071 False False 0 0 0 0 0 0 0 0.49447613003432 0.216118834849999 1.03570402905727 0 0 0.000477349073576999 0.997389253831901 0.996296283622464 0.998225456465932 273 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1191T>C rrs_n.1191T>C 1 non_coding_transcript_exon_variant 1473036 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1719 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.1198G>A rrs_n.1198G>A 1 non_coding_transcript_exon_variant 1473043 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1868 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1551 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1199C>G rrs_n.1199C>G 1 non_coding_transcript_exon_variant 1473044 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1777 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1470 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 11 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1199C>T rrs_n.1199C>T 1 non_coding_transcript_exon_variant 1473044 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1918 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Streptomycin rrs n.11A>C rrs_n.11A>C 1 non_coding_transcript_exon_variant 1471856 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1767 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1461 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1204dupT rrs_n.1204dupT 1 non_coding_transcript_exon_variant 1473047 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1805 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1493 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.1204T>C rrs_n.1204T>C 1 non_coding_transcript_exon_variant 1473049 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1206dupT rrs_n.1206dupT 1 non_coding_transcript_exon_variant 1473050 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.1207G>A rrs_n.1207G>A 1 non_coding_transcript_exon_variant 1473052 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.1208T>A rrs_n.1208T>A 1 non_coding_transcript_exon_variant 1473053 0 0 0 0 6 12 10362 15596 0.000578703703703703 0.000212402724453782 0.00125916554902567 0.999231163505894 0.998657382918185 0.999602669866138 0.333333333333333 0.133427402506123 0.590074761827925 NA NA NA 0 0 0.264648469397051 NA NA NA NA 2142 2512 False False 0.75255742134723 0.231661879081194 2.1674066734118 0 0 0.000355937358633142 0.999231163505894 0.998657382918185 0.999602669866138 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 11 7732 11863 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.999073606198416 0.998343031567643 0.999537459717592 0.266666666666666 0.0778715462910436 0.551003241036971 NA NA NA 0 0 0.284914152918154 NA NA NA NA 1790 2071 False False 0 0 0 0 0 0 0 0.557917509288435 0.129512345891114 1.88374585974208 0 0 0.000476978741026985 0.999073606198416 0.998343031567643 0.999537459717592 85 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1208T>C rrs_n.1208T>C 1 non_coding_transcript_exon_variant 1473053 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Streptomycin rrs n.1208T>G rrs_n.1208T>G 1 non_coding_transcript_exon_variant 1473053 2 12 0 12 1 13 10367 15595 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999167093798052 0.998576126182689 0.999556440358575 0.0714285714285714 0.00180678065912538 0.338684489931821 0 0 0.264648469397051 0 0 0.24705263800047 0 0 0.541522232408035 0.0025219655852772 48 2512 False False 0.115714805113859 0.00272678198231033 0.770665612136054 0 0 0.000355765720726338 0.999167093798052 0.998576126182689 0.999556440358575 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 10 0 10 1 11 7735 11863 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999073606198416 0.998343031567643 0.999537459717592 0.0833333333333333 0.00210759323186022 0.384796165150944 0 0 0.30849710781876 0 0 0.284914152918154 0 0 0.684472046448375 0.00810482055400417 54 2071 False False 0 0 0 0 0 0 0 0.139425280601751 0.00324295653303947 0.959682173145494 0 0 0.000476793790149404 0.999073606198416 0.998343031567643 0.999537459717592 10 3) Uncertain significance No change no 1 +Streptomycin rrs n.1210C>T rrs_n.1210C>T 1 non_coding_transcript_exon_variant 1473055 0 0 0 0 2 1 10366 15607 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999935930292158 0.99964307871082 0.999998377896754 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 1941 2512 False False 3.01119043025274 0.156729426968348 177.474331043773 0 0 0.000355800035063835 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 1 7734 11873 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999915782381674 0.999530859783396 0.999997867796783 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 1616 2071 False False 0 0 0 0 0 0 0 3.07033876389966 0.159799628612092 180.959738606129 0 0 0.000476855424503066 0.999915782381674 0.999530859783396 0.999997867796783 127 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1211A>G rrs_n.1211A>G 1 non_coding_transcript_exon_variant 1473056 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2111 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1762 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.1211A>T rrs_n.1211A>T 1 non_coding_transcript_exon_variant 1473056 0 0 0 0 7 15 10361 15593 0.000675154320987654 0.000271488767107418 0.00139057803317028 0.999038954382368 0.998415396005541 0.999462013453075 0.318181818181818 0.138646521553797 0.54872442757377 NA NA NA 0 0 0.218019360910534 NA NA NA NA 1969 2512 False False 0.702319595920599 0.242159436827137 1.83073717915779 0 0 0.000355971706089883 0.999038954382368 0.998415396005541 0.999462013453075 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 5 14 7731 11860 0.000646328852119958 0.0002098934625097 0.00150766595359595 0.998820953343439 0.9980225505579 0.99935525904558 0.263157894736842 0.0914657849076665 0.512029345345872 NA NA NA 0 0 0.231635761650116 NA NA NA NA 1638 2071 False False 0 0 0 0 0 0 0 0.547886985605262 0.154380239934981 1.61065887914249 0 0 0.000477040423209609 0.998820953343439 0.9980225505579 0.99935525904558 179 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1216T>G rrs_n.1216T>G 1 non_coding_transcript_exon_variant 1473061 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1970 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1639 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1217T>A rrs_n.1217T>A 1 non_coding_transcript_exon_variant 1473062 0 0 0 0 8 14 10360 15594 0.000771604938271604 0.00033318123262376 0.00151980017311994 0.99910302409021 0.99849548434986 0.999509530910458 0.363636363636363 0.171979437646332 0.593423331174353 NA NA NA 0 0 0.231635761650116 NA NA NA NA 1700 2512 False False 0.860121345835631 0.312534634408411 2.19787691666581 0 0 0.000356006060176228 0.99910302409021 0.99849548434986 0.999509530910458 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 6 13 7730 11861 0.00077559462254395 0.000284681048736677 0.00168737281383633 0.998905170961765 0.998128536682641 0.999416924941029 0.31578947368421 0.125760635872983 0.56550156884615 NA NA NA 0 0 0.24705263800047 NA NA NA NA 1405 2071 False False 0 0 0 0 0 0 0 0.70818986963877 0.220630384115051 1.99802801684607 0 0 0.000477102121347592 0.998905170961765 0.998128536682641 0.999416924941029 78 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1217T>G rrs_n.1217T>G 1 non_coding_transcript_exon_variant 1473062 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2151 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1798 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 4 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1219A>G rrs_n.1219A>G 1 non_coding_transcript_exon_variant 1473064 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.1220C>G rrs_n.1220C>G 1 non_coding_transcript_exon_variant 1473065 1 4 0 4 0 4 10368 15604 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.28044779470556 0.155697794255122 153.5 2512 False False 0 0 2.28044779470556 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.71438150990605 0.283358886007265 193.5 2071 False False 0 0 0 0 0 0 0 0 0 3.71438150990605 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.1221A>G rrs_n.1221A>G 1 non_coding_transcript_exon_variant 1473066 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1853 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1539 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 114 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1223A>G rrs_n.1223A>G 1 non_coding_transcript_exon_variant 1473068 0 0 0 0 8 12 10360 15596 0.000771604938271604 0.00033318123262376 0.00151980017311994 0.999231163505894 0.998657382918185 0.999602669866138 0.4 0.191190060725307 0.63945741269251 NA NA NA 0 0 0.264648469397051 NA NA NA NA 2066 2512 False False 1.0036036036036 0.355723013431908 2.67125804246978 0 0 0.000356006060176228 0.999231163505894 0.998657382918185 0.999602669866138 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 6 11 7730 11863 0.00077559462254395 0.000284681048736677 0.00168737281383633 0.999073606198416 0.998343031567643 0.999537459717592 0.352941176470588 0.14209748311022 0.616716336556597 NA NA NA 0 0 0.284914152918154 NA NA NA NA 1723 2071 False False 0 0 0 0 0 0 0 0.837092790779724 0.254085324765121 2.4706054422472 0 0 0.000477102121347592 0.999073606198416 0.998343031567643 0.999537459717592 71 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1225G>A rrs_n.1225G>A 1 non_coding_transcript_exon_variant 1473070 0 0 0 0 3 0 10365 15608 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 1 0.99976368249849 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2049 2512 False False Inf 0.622129167636411 Inf 0 0 0.000355834356021348 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 7733 11874 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 1 0.999689379610589 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1708 2071 False False 0 0 0 0 0 0 0 Inf 0.634338273987677 Inf 0 0 0.000476917074793532 1 0.999689379610589 1 3 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1229C>T rrs_n.1229C>T 1 non_coding_transcript_exon_variant 1473074 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1854 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1540 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1234G>A rrs_n.1234G>A 1 non_coding_transcript_exon_variant 1473079 1 1 0 1 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 58.6634076928655 1 973.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Streptomycin rrs n.1235C>A rrs_n.1235C>A 1 non_coding_transcript_exon_variant 1473080 1 0 0 0 0 7 10368 15601 0 0 0.000355731413006942 0.999551512045105 0.999076163117038 0.999819666176692 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1701 2512 False False 0 0 1.04426933597617 0 0 0.000355731413006942 0.999551512045105 0.999076163117038 0.999819666176692 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 7 7736 11867 0 0 0.000476732171726368 0.999410476671719 0.998785736251934 0.999762949244471 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1406 2071 False False 0 0 0 0 0 0 0 0 0 1.06467742986826 0 0 0.000476732171726368 0.999410476671719 0.998785736251934 0.999762949244471 4 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1235C>G rrs_n.1235C>G 1 non_coding_transcript_exon_variant 1473080 0 0 0 0 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2036 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 0 0 0.000355765720726338 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1696 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1235C>T rrs_n.1235C>T 1 non_coding_transcript_exon_variant 1473080 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1971 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1640 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 11 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1236C>T rrs_n.1236C>T 1 non_coding_transcript_exon_variant 1473081 1 2 0 2 1 4 10367 15604 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999743721168631 0.999343955596995 0.999930168370675 0.2 0.00505076337946806 0.716417936118089 0 0 0.841886116991581 0 0 0.602364635616474 0 0 8.01539361065742 0.520324886423033 452.5 2512 False False 0.376290151442075 0.00764455959995544 3.80334957923739 0 0 0.000355765720726338 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 4 7735 11870 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999663129526697 0.999137704464366 0.999908206750254 0.2 0.00505076337946806 0.716417936118089 0 0 0.841886116991581 0 0 0.602364635616474 0 0 8.17242258163327 0.522235304327817 368.5 2071 False False 0 0 0 0 0 0 0 0.383645765998707 0.00779364023519555 3.87797408017955 0 0 0.000476793790149404 0.999663129526697 0.999137704464366 0.999908206750254 51 3) Uncertain significance No change no 1 +Streptomycin rrs n.1237G>A rrs_n.1237G>A 1 non_coding_transcript_exon_variant 1473082 0 0 0 0 1 6 10367 15602 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999615581752947 0.999163472525571 0.999858912630967 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1882 2512 False False 0.250827947654416 0.00545680578940276 2.0680301831463 0 0 0.000355765720726338 0.999615581752947 0.999163472525571 0.999858912630967 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 7736 11869 0 0 0.000476732171726368 0.999578911908371 0.999017596768841 0.999863260157969 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1564 2071 False False 0 0 0 0 0 0 0 0 0 1.67480496260254 0 0 0.000476732171726368 0.999578911908371 0.999017596768841 0.999863260157969 4 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1239T>A rrs_n.1239T>A 1 non_coding_transcript_exon_variant 1473084 0 0 0 0 1 6 10367 15602 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999615581752947 0.999163472525571 0.999858912630967 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1778 2512 False False 0.250827947654416 0.00545680578940276 2.0680301831463 0 0 0.000355765720726338 0.999615581752947 0.999163472525571 0.999858912630967 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 7736 11869 0 0 0.000476732171726368 0.999578911908371 0.999017596768841 0.999863260157969 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1471 2071 False False 0 0 0 0 0 0 0 0 0 1.67480496260254 0 0 0.000476732171726368 0.999578911908371 0.999017596768841 0.999863260157969 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1239T>C rrs_n.1239T>C 1 non_coding_transcript_exon_variant 1473084 1 15 1 14 3 14 10365 15594 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.99910302409021 0.99849548434986 0.999509530910458 0.176470588235294 0.0379850680706259 0.434317872844283 0.0666666666666666 0.0016864302413527 0.319484566578303 0.0666666666666666 0.0016864302413527 0.319484566578303 0.10746330370064 0.00254545667449436 0.706553617833607 0.00714097131811051 59 2512 False False 0.322389911101922 0.0593965121168808 1.15551875549308 9.64692263168049e-05 2.44238636565143e-06 0.000537373619049235 0.99910302409021 0.99849548434986 0.999509530910458 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 15 1 14 3 14 7733 11860 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 0.998820953343439 0.9980225505579 0.99935525904558 0.176470588235294 0.0379850680706259 0.434317872844283 0.0666666666666666 0.0016864302413527 0.319484566578303 0.0666666666666666 0.0016864302413527 0.319484566578303 0.109549056917477 0.00259468494946719 0.720339650575994 0.00746548841515298 50 2071 False False 0 0 0 0 0 0 0 0.328647170752433 0.0605449404357113 1.17812575235592 0.00012929919834497 3.27356691808869e-06 0.000720196139555935 0.998820953343439 0.9980225505579 0.99935525904558 4 3) Uncertain significance No change no 1 +Streptomycin rrs n.1241C>T rrs_n.1241C>T 1 non_coding_transcript_exon_variant 1473086 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.1242_1244delAAAinsGAAT rrs_n.1242_1244delAAAinsGAAT 1 non_coding_transcript_exon_variant 1473087 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1751 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1447 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.1243A>G rrs_n.1243A>G 1 non_coding_transcript_exon_variant 1473088 1 1 0 1 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 58.6596525903968 1 973.5 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 0 0 0.000355765720726338 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 59.8088564761233 1 806.5 2071 False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 0 0 0.000476793790149404 0.999831564763348 0.99939168785815 0.999979601060482 93 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1244A>C rrs_n.1244A>C 1 non_coding_transcript_exon_variant 1473089 0 0 0 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2152 2512 False False Inf 0.282736080598822 Inf 0 0 0.000355800035063835 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1799 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0 0 0.000476855424503066 1 0.999689379610589 1 2 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1244A>T rrs_n.1244A>T 1 non_coding_transcript_exon_variant 1473089 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1883 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1565 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 4 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1246G>A rrs_n.1246G>A 1 non_coding_transcript_exon_variant 1473091 0 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1702 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1407 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 8 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1248C>A rrs_n.1248C>A 1 non_coding_transcript_exon_variant 1473093 0 0 0 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1825 2512 False False Inf 0.282736080598822 Inf 0 0 0.000355800035063835 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1513 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0 0 0.000476855424503066 1 0.999689379610589 1 2 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1248C>T rrs_n.1248C>T 1 non_coding_transcript_exon_variant 1473093 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1806 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1494 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 74 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1249T>A rrs_n.1249T>A 1 non_coding_transcript_exon_variant 1473094 0 0 0 0 3 6 10365 15602 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999615581752947 0.999163472525571 0.999858912630967 0.333333333333333 0.0748546314196918 0.700704943791459 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1884 2512 False False 0.752629040038591 0.12178352858009 3.52509268945684 0 0 0.000355834356021348 0.999615581752947 0.999163472525571 0.999858912630967 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 5 7734 11869 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999578911908371 0.999017596768841 0.999863260157969 0.285714285714285 0.0366925661760855 0.709579136262657 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1566 2071 False False 0 0 0 0 0 0 0 0.61386087406258 0.0584192274045222 3.75047184857656 0 0 0.000476855424503066 0.999578911908371 0.999017596768841 0.999863260157969 3 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1254T>A rrs_n.1254T>A 1 non_coding_transcript_exon_variant 1473099 0 0 0 0 3 6 10365 15602 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999615581752947 0.999163472525571 0.999858912630967 0.333333333333333 0.0748546314196918 0.700704943791459 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1840 2512 False False 0.752629040038591 0.12178352858009 3.52509268945684 0 0 0.000355834356021348 0.999615581752947 0.999163472525571 0.999858912630967 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 5 7734 11869 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999578911908371 0.999017596768841 0.999863260157969 0.285714285714285 0.0366925661760855 0.709579136262657 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1528 2071 False False 0 0 0 0 0 0 0 0.61386087406258 0.0584192274045222 3.75047184857656 0 0 0.000476855424503066 0.999578911908371 0.999017596768841 0.999863260157969 5 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1254T>G rrs_n.1254T>G 1 non_coding_transcript_exon_variant 1473099 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2112 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1763 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 6 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1255G>A rrs_n.1255G>A 1 non_coding_transcript_exon_variant 1473100 0 0 0 0 2 5 10366 15603 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999679651460789 0.999252573060182 0.999895975781355 0.285714285714285 0.0366925661760855 0.709579136262657 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1792 2512 False False 0.602083735288443 0.0572994001432256 3.67859568857157 0 0 0.000355800035063835 0.999679651460789 0.999252573060182 0.999895975781355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 5 7734 11869 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999578911908371 0.999017596768841 0.999863260157969 0.285714285714285 0.0366925661760855 0.709579136262657 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1482 2071 False False 0 0 0 0 0 0 0 0.61386087406258 0.0584192274045222 3.75047184857656 0 0 0.000476855424503066 0.999578911908371 0.999017596768841 0.999863260157969 38 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1257C>T rrs_n.1257C>T 1 non_coding_transcript_exon_variant 1473102 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 46 3) Uncertain significance No change no 1 +Streptomycin rrs n.1259C>G rrs_n.1259C>G 1 non_coding_transcript_exon_variant 1473104 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.1259C>T rrs_n.1259C>T 1 non_coding_transcript_exon_variant 1473104 1 1 0 1 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 58.6634076928655 1 973.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 59.8138891519084 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 41 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.125G>A rrs_n.125G>A 1 non_coding_transcript_exon_variant 1471970 1 1 0 1 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 58.6540000158548 1 973.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 59.801132462225 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 15 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1264T>C rrs_n.1264T>C 1 non_coding_transcript_exon_variant 1473109 0 0 0 0 2 2 10366 15606 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999871860584315 0.999537193839207 0.999984481345552 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2143 2512 False False 1.50549874590005 0.10909391082996 20.7696540777406 0 0 0.000355800035063835 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1791 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance No change no 1 +Streptomycin rrs n.1265T>G rrs_n.1265T>G 1 non_coding_transcript_exon_variant 1473110 0 0 0 0 3 1 10365 15607 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999935930292158 0.99964307871082 0.999998377896754 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 1720 2512 False False 4.51722141823444 0.362625225225282 236.854590713406 0 0 0.000355834356021348 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 1 7733 11873 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 0.999915782381674 0.999530859783396 0.999997867796783 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 1422 2071 False False 0 0 0 0 0 0 0 4.60610371136686 0.369734697559289 241.512824517625 0 0 0.000476917074793532 0.999915782381674 0.999530859783396 0.999997867796783 48 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1266A>G rrs_n.1266A>G 1 non_coding_transcript_exon_variant 1473111 0 0 0 0 3 1 10365 15607 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999935930292158 0.99964307871082 0.999998377896754 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 2050 2512 False False 4.51722141823444 0.362625225225282 236.854590713406 0 0 0.000355834356021348 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 1 7733 11873 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 0.999915782381674 0.999530859783396 0.999997867796783 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 1709 2071 False False 0 0 0 0 0 0 0 4.60610371136686 0.369734697559289 241.512824517625 0 0 0.000476917074793532 0.999915782381674 0.999530859783396 0.999997867796783 52 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.126A>G rrs_n.126A>G 1 non_coding_transcript_exon_variant 1471971 1 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2113 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1764 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.1270G>C rrs_n.1270G>C 1 non_coding_transcript_exon_variant 1473115 0 0 0 0 2 7 10366 15601 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999551512045105 0.999076163117038 0.999819666176692 0.222222222222222 0.0281449734778982 0.600093573716312 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1752 2512 False False 0.430004685648135 0.0435795940165012 2.25913666217328 0 0 0.000355800035063835 0.999551512045105 0.999076163117038 0.999819666176692 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 6 7735 11868 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999494694290045 0.998900489118281 0.999814539856352 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1448 2071 False False 0 0 0 0 0 0 0 0.255720749838396 0.00556297279916227 2.10858771426871 0 0 0.000476793790149404 0.999494694290045 0.998900489118281 0.999814539856352 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1270G>T rrs_n.1270G>T 1 non_coding_transcript_exon_variant 1473115 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1841 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1529 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 15 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1273T>C rrs_n.1273T>C 1 non_coding_transcript_exon_variant 1473118 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1274C>T rrs_n.1274C>T 1 non_coding_transcript_exon_variant 1473119 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1793 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1483 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1275C>T rrs_n.1275C>T 1 non_coding_transcript_exon_variant 1473120 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1942 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1617 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 8 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1276T>C rrs_n.1276T>C 1 non_coding_transcript_exon_variant 1473121 0 0 0 0 1 7 10367 15601 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999551512045105 0.999076163117038 0.999819666176692 0.125 0.0031597235312519 0.526509670875206 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1826 2512 False False 0.214981603715084 0.00477381113707295 1.6738454938462 0 0 0.000355765720726338 0.999551512045105 0.999076163117038 0.999819666176692 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 6 7735 11868 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999494694290045 0.998900489118281 0.999814539856352 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1514 2071 False False 0 0 0 0 0 0 0 0.255720749838396 0.00556297279916227 2.10858771426871 0 0 0.000476793790149404 0.999494694290045 0.998900489118281 0.999814539856352 100 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1277T>A rrs_n.1277T>A 1 non_coding_transcript_exon_variant 1473122 0 0 0 0 1 7 10367 15601 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999551512045105 0.999076163117038 0.999819666176692 0.125 0.0031597235312519 0.526509670875206 NA NA NA 0 0 0.409616397225003 NA NA NA NA 2114 2512 False False 0.214981603715084 0.00477381113707295 1.6738454938462 0 0 0.000355765720726338 0.999551512045105 0.999076163117038 0.999819666176692 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 6 7736 11868 0 0 0.000476732171726368 0.999494694290045 0.998900489118281 0.999814539856352 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1765 2071 False False 0 0 0 0 0 0 0 0 0 1.30338194607257 0 0 0.000476732171726368 0.999494694290045 0.998900489118281 0.999814539856352 8 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1278A>C rrs_n.1278A>C 1 non_coding_transcript_exon_variant 1473123 1 0 0 0 0 5 10368 15603 0 0 0.000355731413006942 0.999679651460789 0.999252573060182 0.999895975781355 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 2002 2512 False False 0 0 1.64266120859479 0 0 0.000355731413006942 0.999679651460789 0.999252573060182 0.999895975781355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 7736 11870 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1667 2071 False False 0 0 0 0 0 0 0 0 0 2.32513012450998 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1278A>G rrs_n.1278A>G 1 non_coding_transcript_exon_variant 1473123 1 4 1 3 1 4 10367 15604 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999743721168631 0.999343955596995 0.999930168370675 0.2 0.00505076337946806 0.716417936118089 0.25 0.00630946320970987 0.805879550316756 0.2 0.00505076337946806 0.716417936118089 0.501720201922767 0.00956092345641947 6.24974209876977 1 973.5 2512 False False 0.376290151442075 0.00764455959995544 3.80334957923739 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.53497091144149 0.0195519049186736 120.390152361053 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 8 3) Uncertain significance No change no 1 +Streptomycin rrs n.1278A>T rrs_n.1278A>T 1 non_coding_transcript_exon_variant 1473123 0 0 0 0 2 1 10366 15607 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999935930292158 0.99964307871082 0.999998377896754 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 2083 2512 False False 3.01119043025274 0.156729426968348 177.474331043773 0 0 0.000355800035063835 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 1 7734 11873 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999915782381674 0.999530859783396 0.999997867796783 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 1738 2071 False False 0 0 0 0 0 0 0 3.07033876389966 0.159799628612092 180.959738606129 0 0 0.000476855424503066 0.999915782381674 0.999530859783396 0.999997867796783 66 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1279A>T rrs_n.1279A>T 1 non_coding_transcript_exon_variant 1473124 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1794 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1484 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1282G>A rrs_n.1282G>A 1 non_coding_transcript_exon_variant 1473127 1 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1703 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1408 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 3 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1282G>T rrs_n.1282G>T 1 non_coding_transcript_exon_variant 1473127 1 0 0 0 0 5 10368 15603 0 0 0.000355731413006942 0.999679651460789 0.999252573060182 0.999895975781355 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1842 2512 False False 0 0 1.64266120859479 0 0 0.000355731413006942 0.999679651460789 0.999252573060182 0.999895975781355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 7736 11870 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1530 2071 False False 0 0 0 0 0 0 0 0 0 2.32513012450998 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1283C>T rrs_n.1283C>T 1 non_coding_transcript_exon_variant 1473128 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1795 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Streptomycin rrs n.1284C>T rrs_n.1284C>T 1 non_coding_transcript_exon_variant 1473129 1 0 0 0 0 5 10368 15603 0 0 0.000355731413006942 0.999679651460789 0.999252573060182 0.999895975781355 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1843 2512 False False 0 0 1.64266120859479 0 0 0.000355731413006942 0.999679651460789 0.999252573060182 0.999895975781355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 7736 11870 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1531 2071 False False 0 0 0 0 0 0 0 0 0 2.32513012450998 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 5 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1285G>A rrs_n.1285G>A 1 non_coding_transcript_exon_variant 1473130 1 4 0 4 2 5 10366 15603 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999679651460789 0.999252573060182 0.999895975781355 0.285714285714285 0.0366925661760855 0.709579136262657 0 0 0.602364635616474 0 0 0.521823750104981 0 0 2.28074179725928 0.155716747995536 164.5 2512 False False 0.602083735288443 0.0572994001432256 3.67859568857157 0 0 0.000355800035063835 0.999679651460789 0.999252573060182 0.999895975781355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 4 7735 11870 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999663129526697 0.999137704464366 0.999908206750254 0.2 0.00505076337946806 0.716417936118089 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.71454888615166 0.283365695587823 203 2071 False False 0 0 0 0 0 0 0 0.383645765998707 0.00779364023519555 3.87797408017955 0 0 0.000476793790149404 0.999663129526697 0.999137704464366 0.999908206750254 41 3) Uncertain significance No change no 1 +Streptomycin rrs n.1286G>A rrs_n.1286G>A 1 non_coding_transcript_exon_variant 1473131 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2097 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1751 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.1286G>T rrs_n.1286G>T 1 non_coding_transcript_exon_variant 1473131 0 0 0 0 1 6 10367 15602 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999615581752947 0.999163472525571 0.999858912630967 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1687 2512 False False 0.250827947654416 0.00545680578940276 2.0680301831463 0 0 0.000355765720726338 0.999615581752947 0.999163472525571 0.999858912630967 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 5 7735 11869 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999578911908371 0.999017596768841 0.999863260157969 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1394 2071 False False 0 0 0 0 0 0 0 0.306890756302521 0.00649200912492085 2.74344385104518 0 0 0.000476793790149404 0.999578911908371 0.999017596768841 0.999863260157969 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1290C>T rrs_n.1290C>T 1 non_coding_transcript_exon_variant 1473135 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2051 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1710 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1300C>T rrs_n.1300C>T 1 non_coding_transcript_exon_variant 1473145 0 0 0 0 3 3 10365 15605 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999807790876473 0.99943838714673 0.999960360103688 0.5 0.118117248757025 0.881882751242974 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2115 2512 False False 1.50554751567776 0.201606412693291 11.2464963121379 0 0 0.000355834356021348 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 3 7733 11871 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 0.999747347145022 0.999261820436506 0.999947893876346 0.5 0.118117248757025 0.881882751242974 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1766 2071 False False 0 0 0 0 0 0 0 1.53510927195137 0.205550714955708 11.4678941037862 0 0 0.000476917074793532 0.999747347145022 0.999261820436506 0.999947893876346 146 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1302G>A rrs_n.1302G>A 1 non_coding_transcript_exon_variant 1473147 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1956 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1629 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 9 3) Uncertain significance No change no 1 +Streptomycin rrs n.1302G>C rrs_n.1302G>C 1 non_coding_transcript_exon_variant 1473147 0 0 0 0 4 7 10364 15601 0.000385802469135802 0.000105127872737001 0.000987510251175401 0.999551512045105 0.999076163117038 0.999819666176692 0.363636363636363 0.109263443819098 0.692095284988322 NA NA NA 0 0 0.409616397225003 NA NA NA NA 2098 2512 False False 0.860175332193857 0.184612886649235 3.38458769855359 0 0 0.000355868683600791 0.999551512045105 0.999076163117038 0.999819666176692 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 6 7734 11868 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999494694290045 0.998900489118281 0.999814539856352 0.25 0.0318540262499442 0.650855794412824 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1752 2071 False False 0 0 0 0 0 0 0 0.511507628652702 0.0504799102640932 2.8615766008904 0 0 0.000476855424503066 0.999494694290045 0.998900489118281 0.999814539856352 2 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1302G>T rrs_n.1302G>T 1 non_coding_transcript_exon_variant 1473147 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1869 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1552 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 3 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1303G>A rrs_n.1303G>A 1 non_coding_transcript_exon_variant 1473148 0 0 0 0 4 9 10364 15599 0.000385802469135802 0.000105127872737001 0.000987510251175401 0.99942337262942 0.998905665124108 0.999736296428239 0.307692307692307 0.0909203945720966 0.614261661750705 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1972 2512 False False 0.668939491401861 0.150491714930531 2.39753666739202 0 0 0.000355868683600791 0.99942337262942 0.998905665124108 0.999736296428239 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 8 7734 11866 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999326259053394 0.998672895689377 0.999709083033384 0.2 0.0252107263268333 0.556095462307641 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1641 2071 False False 0 0 0 0 0 0 0 0.383566071890354 0.0396726760071963 1.92279965315068 0 0 0.000476855424503066 0.999326259053394 0.998672895689377 0.999709083033384 8 3) Uncertain significance No change no 1 +Streptomycin rrs n.1305T>G rrs_n.1305T>G 1 non_coding_transcript_exon_variant 1473150 0 0 0 0 2 1 10366 15607 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999935930292158 0.99964307871082 0.999998377896754 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 1986 2512 False False 3.01119043025274 0.156729426968348 177.474331043773 0 0 0.000355800035063835 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 1 7734 11873 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999915782381674 0.999530859783396 0.999997867796783 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 1653 2071 False False 0 0 0 0 0 0 0 3.07033876389966 0.159799628612092 180.959738606129 0 0 0.000476855424503066 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.-130T>C rrs_n.-130T>C 1 upstream_gene_variant 1471716 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2047 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1316A>C rrs_n.1316A>C 1 non_coding_transcript_exon_variant 1473161 0 0 0 0 2 1 10366 15607 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999935930292158 0.99964307871082 0.999998377896754 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 2153 2512 False False 3.01119043025274 0.156729426968348 177.474331043773 0 0 0.000355800035063835 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 1 7734 11873 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999915782381674 0.999530859783396 0.999997867796783 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 1800 2071 False False 0 0 0 0 0 0 0 3.07033876389966 0.159799628612092 180.959738606129 0 0 0.000476855424503066 0.999915782381674 0.999530859783396 0.999997867796783 5 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1318C>T rrs_n.1318C>T 1 non_coding_transcript_exon_variant 1473163 0 0 0 0 3 8 10365 15600 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999487442337262 0.998990308225149 0.99977868883794 0.272727272727272 0.0602177341729066 0.609742559572421 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1987 2512 False False 0.564399421128798 0.0964092202317815 2.35228955636283 0 0 0.000355834356021348 0.999487442337262 0.998990308225149 0.99977868883794 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 7 7734 11867 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999410476671719 0.998785736251934 0.999762949244471 0.222222222222222 0.0281449734778982 0.600093573716312 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1654 2071 False False 0 0 0 0 0 0 0 0.438398167645646 0.044427948910893 2.30343996509364 0 0 0.000476855424503066 0.999410476671719 0.998785736251934 0.999762949244471 10 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1319C>A rrs_n.1319C>A 1 non_coding_transcript_exon_variant 1473164 1 1 0 1 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 58.6502452744631 1 973.5 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 59.7961004349848 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 3.71438150990605 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 3 3) Uncertain significance No change no 1 +Streptomycin rrs n.1319C>G rrs_n.1319C>G 1 non_coding_transcript_exon_variant 1473164 0 0 0 0 3 7 10365 15601 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999551512045105 0.999076163117038 0.999819666176692 0.3 0.0667395111777345 0.652452850059997 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1988 2512 False False 0.645069257804424 0.107584929606629 2.8264834997856 0 0 0.000355834356021348 0.999551512045105 0.999076163117038 0.999819666176692 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 6 7734 11868 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999494694290045 0.998900489118281 0.999814539856352 0.25 0.0318540262499442 0.650855794412824 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1655 2071 False False 0 0 0 0 0 0 0 0.511507628652702 0.0504799102640932 2.8615766008904 0 0 0.000476855424503066 0.999494694290045 0.998900489118281 0.999814539856352 2 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1319C>T rrs_n.1319C>T 1 non_coding_transcript_exon_variant 1473164 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1885 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1567 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 5 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1320C>G rrs_n.1320C>G 1 non_coding_transcript_exon_variant 1473165 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1827 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1515 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1321G>A rrs_n.1321G>A 1 non_coding_transcript_exon_variant 1473166 0 0 0 0 3 3 10365 15605 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999807790876473 0.99943838714673 0.999960360103688 0.5 0.118117248757025 0.881882751242974 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2067 2512 False False 1.50554751567776 0.201606412693291 11.2464963121379 0 0 0.000355834356021348 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 3 7733 11871 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 0.999747347145022 0.999261820436506 0.999947893876346 0.5 0.118117248757025 0.881882751242974 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1724 2071 False False 0 0 0 0 0 0 0 1.53510927195137 0.205550714955708 11.4678941037862 0 0 0.000476917074793532 0.999747347145022 0.999261820436506 0.999947893876346 148 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1322T>G rrs_n.1322T>G 1 non_coding_transcript_exon_variant 1473167 0 0 0 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1704 2512 False False Inf 0.282736080598822 Inf 0 0 0.000355800035063835 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1323G>T rrs_n.1323G>T 1 non_coding_transcript_exon_variant 1473168 1 2 0 2 0 5 10368 15603 0 0 0.000355731413006942 0.999679651460789 0.999252573060182 0.999895975781355 0 0 0.521823750104981 0 0 0.841886116991581 0 0 0.521823750104981 0 0 8.01410691564285 0.520309356547321 431 2512 False False 0 0 1.64266120859479 0 0 0.000355731413006942 0.999679651460789 0.999252573060182 0.999895975781355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 4 7736 11870 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 59.7910684069526 1 512 2071 False False 0 0 0 0 0 0 0 0 0 2.32513012450998 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 7 3) Uncertain significance No change no 1 +Streptomycin rrs n.1325A>C rrs_n.1325A>C 1 non_coding_transcript_exon_variant 1473170 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1919 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1596 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.1327T>C rrs_n.1327T>C 1 non_coding_transcript_exon_variant 1473172 0 0 0 0 1 10 10367 15598 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999359302921578 0.998822051949738 0.999692719453314 0.0909090909090909 0.00229897221381426 0.412779916988382 NA NA NA 0 0 0.30849710781876 NA NA NA NA 1807 2512 False True 0.150458184624288 0.00347081599231064 1.05796227786788 0 0 0.000355765720726338 0.999359302921578 0.998822051949738 0.999692719453314 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 0 9 7736 11865 0 0 0.000476732171726368 0.999242041435068 0.998561648359028 0.999653356368186 0 0 0.336267116879942 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1495 2071 False True 0 1 1 0 0 0 0 0 0 0.777323095649869 0 0 0.000476732171726368 0.999242041435068 0.998561648359028 0.999653356368186 8 5) Not assoc w R New NotAwR yes 5 +Streptomycin rrs n.1327T>G rrs_n.1327T>G 1 non_coding_transcript_exon_variant 1473172 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 49 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1328C>T rrs_n.1328C>T 1 non_coding_transcript_exon_variant 1473173 NA 0 0 0 2 9 10366 15599 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.99942337262942 0.998905665124108 0.999736296428239 0.181818181818181 0.0228311982999596 0.517755852360172 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1736 2512 False True 0.334405213625742 0.0351449615056338 1.61615001031672 0 0 0.000355800035063835 0.99942337262942 0.998905665124108 0.999736296428239 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 1 8 7735 11866 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999326259053394 0.998672895689377 0.999709083033384 0.111111111111111 0.00280913674659921 0.482496514917337 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1434 2071 False True 0 1 1 0 0 0 0 0.191758241758241 0.00432517143892361 1.43088714399149 0 0 0.000476793790149404 0.999326259053394 0.998672895689377 0.999709083033384 52 5) Not assoc w R New NotAwR yes 5 +Streptomycin rrs n.1330G>A rrs_n.1330G>A 1 non_coding_transcript_exon_variant 1473175 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1332G>A rrs_n.1332G>A 1 non_coding_transcript_exon_variant 1473177 0 0 0 0 7 14 10361 15594 0.000675154320987654 0.000271488767107418 0.00139057803317028 0.99910302409021 0.99849548434986 0.999509530910458 0.333333333333333 0.145876942343096 0.569675482904124 NA NA NA 0 0 0.231635761650116 NA NA NA NA 2129 2512 False False 0.752533539233664 0.256962768329295 1.99321706073012 0 0 0.000355971706089883 0.99910302409021 0.99849548434986 0.999509530910458 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 13 7732 11861 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.998905170961765 0.998128536682641 0.999416924941029 0.235294117647058 0.0681077404373566 0.49899327320458 NA NA NA 0 0 0.24705263800047 NA NA NA NA 1779 2071 False False 0 0 0 0 0 0 0 0.47200445700187 0.112073032823122 1.52860257516419 0 0 0.000476978741026985 0.998905170961765 0.998128536682641 0.999416924941029 131 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1334C>T rrs_n.1334C>T 1 non_coding_transcript_exon_variant 1473179 0 0 0 0 5 0 10363 15608 0.000482253086419753 0.000156604214122162 0.00112505595550109 1 0.99976368249849 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 2130 2512 False False Inf 1.37979907306709 Inf 0 0 0.000355903017804084 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 0 7732 11874 0.000517063081695967 0.000140899683864147 0.00132335286075948 1 0.999689379610589 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 1780 2071 False False 0 0 0 0 0 0 0 Inf 1.01342344657205 Inf 0 0 0.000476978741026985 1 0.999689379610589 1 2 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.133C>T rrs_n.133C>T 1 non_coding_transcript_exon_variant 1471978 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2037 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1697 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1346C>T rrs_n.1346C>T 1 non_coding_transcript_exon_variant 1473191 0 0 0 0 3 9 10365 15599 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.99942337262942 0.998905665124108 0.999736296428239 0.25 0.0548606445279927 0.571858461878189 NA NA NA 0 0 0.336267116879942 NA NA NA NA 2131 2512 False False 0.501656214825534 0.0873365176194113 2.0107394750464 0 0 0.000355834356021348 0.99942337262942 0.998905665124108 0.999736296428239 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 8 7734 11866 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999326259053394 0.998672895689377 0.999709083033384 0.2 0.0252107263268333 0.556095462307641 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1781 2071 False False 0 0 0 0 0 0 0 0.383566071890354 0.0396726760071963 1.92279965315068 0 0 0.000476855424503066 0.999326259053394 0.998672895689377 0.999709083033384 8 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1347A>G rrs_n.1347A>G 1 non_coding_transcript_exon_variant 1473192 0 0 0 0 8 12 10360 15596 0.000771604938271604 0.00033318123262376 0.00151980017311994 0.999231163505894 0.998657382918185 0.999602669866138 0.4 0.191190060725307 0.63945741269251 NA NA NA 0 0 0.264648469397051 NA NA NA NA 1989 2512 False False 1.0036036036036 0.355723013431908 2.67125804246978 0 0 0.000356006060176228 0.999231163505894 0.998657382918185 0.999602669866138 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 11 7732 11863 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.999073606198416 0.998343031567643 0.999537459717592 0.266666666666666 0.0778715462910436 0.551003241036971 NA NA NA 0 0 0.284914152918154 NA NA NA NA 1656 2071 False False 0 0 0 0 0 0 0 0.557917509288435 0.129512345891114 1.88374585974208 0 0 0.000476978741026985 0.999073606198416 0.998343031567643 0.999537459717592 155 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.134T>C rrs_n.134T>C 1 non_coding_transcript_exon_variant 1471979 0 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1943 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1618 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.-134T>C rrs_n.-134T>C 1 upstream_gene_variant 1471712 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.1356_1357delACinsT rrs_n.1356_1357delACinsT 1 non_coding_transcript_exon_variant 1473201 0 0 0 0 4 12 10364 15596 0.000385802469135802 0.000105127872737001 0.000987510251175401 0.999231163505894 0.998657382918185 0.999602669866138 0.25 0.0726620382528822 0.523770819896127 NA NA NA 0 0 0.264648469397051 NA NA NA NA 1828 2512 False False 0.501608130708864 0.117879712992309 1.65567172231467 0 0 0.000355868683600791 0.999231163505894 0.998657382918185 0.999602669866138 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 11 7733 11863 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 0.999073606198416 0.998343031567643 0.999537459717592 0.214285714285714 0.0465792878898673 0.507975677048471 NA NA NA 0 0 0.284914152918154 NA NA NA NA 1516 2071 False False 0 0 0 0 0 0 0 0.418384021254834 0.0749239120687622 1.58455503072556 0 0 0.000476917074793532 0.999073606198416 0.998343031567643 0.999537459717592 9 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1356_1360delACGCTinsTGCC rrs_n.1356_1360delACGCTinsTGCC 1 non_coding_transcript_exon_variant 1473201 0 0 0 0 6 8 10362 15600 0.000578703703703703 0.000212402724453782 0.00125916554902567 0.999487442337262 0.998990308225149 0.99977868883794 0.428571428571428 0.176611089982117 0.711390599961692 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1705 2512 False False 1.12912565141864 0.322800697944735 3.71172362665047 0 0 0.000355937358633142 0.999487442337262 0.998990308225149 0.99977868883794 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 7 7733 11867 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 0.999410476671719 0.998785736251934 0.999762949244471 0.3 0.0667395111777345 0.652452850059997 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1409 2071 False False 0 0 0 0 0 0 0 0.657682289261236 0.109739874070061 2.88202574760339 0 0 0.000476917074793532 0.999410476671719 0.998785736251934 0.999762949244471 14 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1356delA rrs_n.1356delA 1 non_coding_transcript_exon_variant 1473199 1 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2052 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1711 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 143 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1358G>T rrs_n.1358G>T 1 non_coding_transcript_exon_variant 1473203 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2019 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1680 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.135G>T rrs_n.135G>T 1 non_coding_transcript_exon_variant 1471980 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2084 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1739 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 9 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1360T>C rrs_n.1360T>C 1 non_coding_transcript_exon_variant 1473205 1 0 0 0 0 4 10368 15604 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1973 2512 False False 0 0 2.28044779470556 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 7736 11870 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1642 2071 False False 0 0 0 0 0 0 0 0 0 2.32513012450998 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 160 3) Uncertain significance No change no 1 +Streptomycin rrs n.1361G>A rrs_n.1361G>A 1 non_coding_transcript_exon_variant 1473206 0 0 0 0 4 11 10364 15597 0.000385802469135802 0.000105127872737001 0.000987510251175401 0.999295233213736 0.998739328260189 0.999648132128855 0.266666666666666 0.0778715462910436 0.551003241036971 NA NA NA 0 0 0.284914152918154 NA NA NA NA 2154 2512 False False 0.547243956352408 0.127053504005292 1.84748938892664 0 0 0.000355868683600791 0.999295233213736 0.998739328260189 0.999648132128855 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 10 7733 11864 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 0.999157823816742 0.998451755191613 0.9995960722577 0.23076923076923 0.0503810734911515 0.53813153923404 NA NA NA 0 0 0.30849710781876 NA NA NA NA 1801 2071 False False 0 0 0 0 0 0 0 0.460261218155955 0.0813712613668843 1.78838261064702 0 0 0.000476917074793532 0.999157823816742 0.998451755191613 0.9995960722577 7 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1361G>C rrs_n.1361G>C 1 non_coding_transcript_exon_variant 1473206 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1855 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1541 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1367A>G rrs_n.1367A>G 1 non_coding_transcript_exon_variant 1473212 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1896 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.136C>A rrs_n.136C>A 1 non_coding_transcript_exon_variant 1471981 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance No change no 1 +Streptomycin rrs n.136C>T rrs_n.136C>T 1 non_coding_transcript_exon_variant 1471981 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2003 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1668 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1370A>G rrs_n.1370A>G 1 non_coding_transcript_exon_variant 1473215 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.1379G>A rrs_n.1379G>A 1 non_coding_transcript_exon_variant 1473224 1 9 0 9 0 9 10368 15599 0 0 0.000355731413006942 0.99942337262942 0.998905665124108 0.999736296428239 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.762426796904344 0.0139347599364063 74.5 2512 False False 0 0 0.762426796904344 0 0 0.000355731413006942 0.99942337262942 0.998905665124108 0.999736296428239 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 7 7736 11867 0 0 0.000476732171726368 0.999410476671719 0.998785736251934 0.999762949244471 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 1.06467742986826 0.047267663661775 82 2071 False False 0 0 0 0 0 0 0 0 0 1.06467742986826 0 0 0.000476732171726368 0.999410476671719 0.998785736251934 0.999762949244471 4 3) Uncertain significance No change no 1 +Streptomycin rrs n.1381C>T rrs_n.1381C>T 1 non_coding_transcript_exon_variant 1473226 0 0 0 0 8 11 10360 15597 0.000771604938271604 0.00033318123262376 0.00151980017311994 0.999295233213736 0.998739328260189 0.999648132128855 0.421052631578947 0.202521438977162 0.665002155988264 NA NA NA 0 0 0.284914152918154 NA NA NA NA 1897 2512 False False 1.09491049491049 0.382183879836686 2.98972267481287 0 0 0.000356006060176228 0.999295233213736 0.998739328260189 0.999648132128855 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 6 10 7730 11864 0.00077559462254395 0.000284681048736677 0.00168737281383633 0.999157823816742 0.998451755191613 0.9995960722577 0.375 0.151983675081122 0.645653905697921 NA NA NA 0 0 0.30849710781876 NA NA NA NA 1577 2071 False False 0 0 0 0 0 0 0 0.920879689521345 0.274945680540798 2.79790030669871 0 0 0.000477102121347592 0.999157823816742 0.998451755191613 0.9995960722577 17 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1382C>G rrs_n.1382C>G 1 non_coding_transcript_exon_variant 1473227 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2004 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.138C>T rrs_n.138C>T 1 non_coding_transcript_exon_variant 1471983 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2068 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1725 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.13A>G rrs_n.13A>G 1 non_coding_transcript_exon_variant 1471858 0 0 0 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2020 2512 False False Inf 0.282736080598822 Inf 0 0 0.000355800035063835 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1681 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0 0 0.000476855424503066 1 0.999689379610589 1 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.1401A>G rrs_n.1401A>G 1 non_coding_transcript_exon_variant 1473246 1 56 22 34 1133 130 9235 15478 0.109278549382716 0.103335304467263 0.115442224075909 0.991670937980522 0.990117646196521 0.993036534368533 0.897070467141726 0.878981599149341 0.913285364993067 0.392857142857142 0.264991262503728 0.532463072554213 0.144736842105263 0.0929826974734054 0.210894963095856 1.08448039746488 0.603852230391855 1.91005566513381 0.783103404785653 597 2512 False False 14.6071167381616 12.1454820685014 17.6774905717832 0.00237657988549206 0.00148997071137316 0.00359597242709061 0.991670937980522 0.990117646196521 0.993036534368533 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 32 15 17 804 52 6932 11822 0.103929679420889 0.0972148478039622 0.110944541100337 0.99562068384706 0.994261027270319 0.996727639486314 0.939252336448598 0.921097371580346 0.954301581513684 0.46875 0.290939822906015 0.652563190713607 0.223880597014925 0.13105934585359 0.342232846544333 1.50478598825566 0.699241646021164 3.20536287221302 0.272959733716752 173 2071 False False 0 0 0 0 0 0 0 26.3684806249722 19.8727868702708 35.694773399302 0.00215920541240823 0.00120897877043594 0.00355878428435271 0.99562068384706 0.994261027270319 0.996727639486314 1475 3) Uncertain significance No change no 1 +Streptomycin rrs n.1402C>A rrs_n.1402C>A 1 non_coding_transcript_exon_variant 1473247 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1808 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1496 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 20 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1402C>T rrs_n.1402C>T 1 non_coding_transcript_exon_variant 1473247 0 0 0 0 19 0 10349 15608 0.00183256172839506 0.00110367119743855 0.00286029933187508 1 0.99976368249849 1 1 0.823533088193034 1 NA NA NA NA NA NA NA NA NA NA 1844 2512 False False Inf 7.03575077981888 Inf 0 0 0.000356384393229329 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 15 0 7721 11874 0.00193898655635987 0.00108562946918638 0.00319605008438842 1 0.999689379610589 1 1 0.781980639089466 1 NA NA NA NA NA NA NA NA NA NA 1532 2071 False False 0 0 0 0 0 0 0 Inf 5.51360376948071 Inf 0 0 0.000477658123603289 1 0.999689379610589 1 19 3) Uncertain significance No change no 1 +Streptomycin rrs n.1403G>A rrs_n.1403G>A 1 non_coding_transcript_exon_variant 1473248 0 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1898 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1578 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 3 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1404T>C rrs_n.1404T>C 1 non_coding_transcript_exon_variant 1473249 0 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1721 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1423 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 3 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1407T>C rrs_n.1407T>C 1 non_coding_transcript_exon_variant 1473252 0 0 0 0 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1944 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 0 0 0.000355765720726338 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1619 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 83 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1409A>G rrs_n.1409A>G 1 non_coding_transcript_exon_variant 1473254 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance No change no 1 +Streptomycin rrs n.140T>C rrs_n.140T>C 1 non_coding_transcript_exon_variant 1471985 0 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1722 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1424 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 9 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.140T>G rrs_n.140T>G 1 non_coding_transcript_exon_variant 1471985 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.1410A>G rrs_n.1410A>G 1 non_coding_transcript_exon_variant 1473255 0 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1920 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1597 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 2 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1413T>C rrs_n.1413T>C 1 non_coding_transcript_exon_variant 1473258 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2038 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1698 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1414C>T rrs_n.1414C>T 1 non_coding_transcript_exon_variant 1473259 0 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1688 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1395 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 88 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1415G>T rrs_n.1415G>T 1 non_coding_transcript_exon_variant 1473260 0 0 0 0 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2116 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 0 0 0.000355765720726338 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1767 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance No change no 1 +Streptomycin rrs n.-141A>G rrs_n.-141A>G 1 upstream_gene_variant 1471705 1 2 0 2 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01642086402598 0.520337288498982 548 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 0 0 0.000355765720726338 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 6 3) Uncertain significance No change no 1 +Streptomycin rrs n.141C>T rrs_n.141C>T 1 non_coding_transcript_exon_variant 1471986 1 2 0 2 1 3 10367 15605 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999807790876473 0.99943838714673 0.999960360103688 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.01590723734217 0.520331087227479 541.5 2512 False False 0.501752355229735 0.00956153582768186 6.25014259670444 0 0 0.000355765720726338 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 59.8088564761233 1 806.5 2071 False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 0 0 0.000476793790149404 0.999831564763348 0.99939168785815 0.999979601060482 15 3) Uncertain significance No change no 1 +Streptomycin rrs n.142G>A rrs_n.142G>A 1 non_coding_transcript_exon_variant 1471987 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1796 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1485 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 12 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1430C>T rrs_n.1430C>T 1 non_coding_transcript_exon_variant 1473275 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1431A>G rrs_n.1431A>G 1 non_coding_transcript_exon_variant 1473276 0 0 0 0 1 3 10367 15605 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999807790876473 0.99943838714673 0.999960360103688 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1797 2512 False False 0.501752355229735 0.00956153582768186 6.25014259670444 0 0 0.000355765720726338 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1486 2071 False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 0 0 0.000476793790149404 0.999831564763348 0.99939168785815 0.999979601060482 35 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1435G>A rrs_n.1435G>A 1 non_coding_transcript_exon_variant 1473280 1 3 0 3 1 3 10367 15605 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999807790876473 0.99943838714673 0.999960360103688 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.64334605529666 0.280505932748473 259.5 2512 False False 0.501752355229735 0.00956153582768186 6.25014259670444 0 0 0.000355765720726338 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 1 3 7735 11871 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999747347145022 0.999261820436506 0.999947893876346 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.7148618120425 0.283378435813045 205.5 2071 False False 0 0 0 0 0 0 0 0.511570782159017 0.0097482170621519 6.37282132403124 0 0 0.000476793790149404 0.999747347145022 0.999261820436506 0.999947893876346 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.1436C>A rrs_n.1436C>A 1 non_coding_transcript_exon_variant 1473281 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1870 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1436C>G rrs_n.1436C>G 1 non_coding_transcript_exon_variant 1473281 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1436C>T rrs_n.1436C>T 1 non_coding_transcript_exon_variant 1473281 0 0 0 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1706 2512 False False Inf 0.282736080598822 Inf 0 0 0.000355800035063835 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1410 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0 0 0.000476855424503066 1 0.999689379610589 1 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.1437C>G rrs_n.1437C>G 1 non_coding_transcript_exon_variant 1473282 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1957 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1443_1446delCTCGinsTTTTA rrs_n.1443_1446delCTCGinsTTTTA 1 non_coding_transcript_exon_variant 1473288 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1768 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1443C>G rrs_n.1443C>G 1 non_coding_transcript_exon_variant 1473288 1 45 3 42 17 44 10351 15564 0.00163966049382716 0.0009554436768022 0.00262396149717064 0.997180932854946 0.996217361342434 0.997950937058336 0.278688524590163 0.17147208426028 0.408287466756179 0.0666666666666666 0.0139650970443705 0.182684456578226 0.0638297872340425 0.0133617694972549 0.17539243001292 0.107401631312364 0.0213121545553777 0.336245359048717 7.63401067907727e-07 24 2512 True False 0.580945187553244 0.311010496810262 1.03820924521517 0.000289743094456248 5.97559780019454e-05 0.00084651648066852 0.997180932854946 0.996217361342434 0.997950937058336 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 37 3 34 17 36 7719 11838 0.00219751809720785 0.00128064014327926 0.00351611538908953 0.996968165740272 0.995805110243945 0.997875664594965 0.320754716981132 0.199186646831634 0.46316122877156 0.081081081081081 0.0170435306958188 0.219096206238 0.0769230769230769 0.0161533003106583 0.208701921226443 0.13531926567751 0.0265846470902978 0.430545993628281 2.93665339815051e-05 28 2071 True False 0 0 0 0 0 0 0 0.724208662607418 0.381174945935403 1.32425732614604 0.000388500388500388 8.01252869988489e-05 0.00113493908693179 0.996968165740272 0.995805110243945 0.997875664594965 27 3) Uncertain significance No change no 1 +Streptomycin rrs n.1444_1445delTCinsCTCGT rrs_n.1444_1445delTCinsCTCGT 1 non_coding_transcript_exon_variant 1473289 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2099 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1753 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1445_1449delCGGGAinsTGTGGG rrs_n.1445_1449delCGGGAinsTGTGGG 1 non_coding_transcript_exon_variant 1473290 1 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2053 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1712 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 3 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1445C>A rrs_n.1445C>A 1 non_coding_transcript_exon_variant 1473290 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1845 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1533 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1446G>A rrs_n.1446G>A 1 non_coding_transcript_exon_variant 1473291 1 2 0 2 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.01513406993295 0.520321755085951 445 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 59.801132462225 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 1 3) Uncertain significance No change no 1 +Streptomycin rrs n.1448G>C rrs_n.1448G>C 1 non_coding_transcript_exon_variant 1473293 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1779 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1472 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1449A>G rrs_n.1449A>G 1 non_coding_transcript_exon_variant 1473294 0 0 0 0 8 0 10360 15608 0.000771604938271604 0.00033318123262376 0.00151980017311994 1 0.99976368249849 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 2155 2512 False False Inf 2.57069745416703 Inf 0 0 0.000356006060176228 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance No change no 1 +Streptomycin rrs n.1450G>A rrs_n.1450G>A 1 non_coding_transcript_exon_variant 1473295 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.1451G>C rrs_n.1451G>C 1 non_coding_transcript_exon_variant 1473296 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1899 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1452G>T rrs_n.1452G>T 1 non_coding_transcript_exon_variant 1473297 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1723 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1456T>C rrs_n.1456T>C 1 non_coding_transcript_exon_variant 1473301 0 0 0 0 1 3 10367 15605 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999807790876473 0.99943838714673 0.999960360103688 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2144 2512 False False 0.501752355229735 0.00956153582768186 6.25014259670444 0 0 0.000355765720726338 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1792 2071 False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 0 0 0.000476793790149404 0.999831564763348 0.99939168785815 0.999979601060482 27 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1457G>A rrs_n.1457G>A 1 non_coding_transcript_exon_variant 1473302 1 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1945 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1620 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.1460G>A rrs_n.1460G>A 1 non_coding_transcript_exon_variant 1473305 1 0 0 0 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1809 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1497 2071 False False 0 0 0 0 0 0 0 0 0 3.71438150990605 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 2 3) Uncertain significance No change no 1 +Streptomycin rrs n.1461A>G rrs_n.1461A>G 1 non_coding_transcript_exon_variant 1473306 1 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2156 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1802 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.1467G>C rrs_n.1467G>C 1 non_coding_transcript_exon_variant 1473312 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2157 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1803 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1469A>G rrs_n.1469A>G 1 non_coding_transcript_exon_variant 1473314 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance No change no 1 +Streptomycin rrs n.1470T>C rrs_n.1470T>C 1 non_coding_transcript_exon_variant 1473315 0 0 0 0 1 3 10367 15605 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999807790876473 0.99943838714673 0.999960360103688 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2021 2512 False False 0.501752355229735 0.00956153582768186 6.25014259670444 0 0 0.000355765720726338 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1682 2071 False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 0 0 0.000476793790149404 0.999831564763348 0.99939168785815 0.999979601060482 16 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1471C>A rrs_n.1471C>A 1 non_coding_transcript_exon_variant 1473316 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2005 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1471C>T rrs_n.1471C>T 1 non_coding_transcript_exon_variant 1473316 0 0 0 0 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1798 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 0 0 0.000355765720726338 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1487 2071 False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 0 0 0.000476793790149404 0.999831564763348 0.99939168785815 0.999979601060482 69 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1472G>A rrs_n.1472G>A 1 non_coding_transcript_exon_variant 1473317 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1780 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1473G>A rrs_n.1473G>A 1 non_coding_transcript_exon_variant 1473318 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1829 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1474C>T rrs_n.1474C>T 1 non_coding_transcript_exon_variant 1473319 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2100 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.-147G>T rrs_n.-147G>T 1 upstream_gene_variant 1471699 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1803 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1491 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1482A>G rrs_n.1482A>G 1 non_coding_transcript_exon_variant 1473327 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2006 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1483C>T rrs_n.1483C>T 1 non_coding_transcript_exon_variant 1473328 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1974 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1484G>T rrs_n.1484G>T 1 non_coding_transcript_exon_variant 1473329 2 2 0 2 10 7 10358 15601 0.000964506172839506 0.000462612020337809 0.00177304351401163 0.999551512045105 0.999076163117038 0.999819666176692 0.588235294117647 0.329247153946757 0.815563038216053 0 0 0.841886116991581 0 0 0.409616397225003 0 0 8.02081617028979 0.52039035796791 562 2512 False False 2.15168399856563 0.739049937150205 6.66319420713676 0 0 0.000356074788245403 0.999551512045105 0.999076163117038 0.999819666176692 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 2 0 2 5 6 7731 11868 0.000646328852119958 0.0002098934625097 0.00150766595359595 0.999494694290045 0.998900489118281 0.999814539856352 0.454545454545454 0.167488094063707 0.766206402340654 0 0 0.841886116991581 0 0 0.4592581264399 0 0 8.17527365435218 0.522270469332572 462 2071 False False 0 0 0 0 0 0 0 1.27926529556331 0.308753662413996 5.03281926496319 0 0 0.000477040423209609 0.999494694290045 0.998900489118281 0.999814539856352 39 3) Uncertain significance No change no 1 +Streptomycin rrs n.1489C>T rrs_n.1489C>T 1 non_coding_transcript_exon_variant 1473334 0 0 0 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1958 2512 False False Inf 0.282736080598822 Inf 0 0 0.000355800035063835 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Streptomycin rrs n.1491T>A rrs_n.1491T>A 1 non_coding_transcript_exon_variant 1473336 0 0 0 0 3 0 10365 15608 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 1 0.99976368249849 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1810 2512 False False Inf 0.622129167636411 Inf 0 0 0.000355834356021348 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 7733 11874 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 1 0.999689379610589 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1498 2071 False False 0 0 0 0 0 0 0 Inf 0.634338273987677 Inf 0 0 0.000476917074793532 1 0.999689379610589 1 4 3) Uncertain significance No change no 1 +Streptomycin rrs n.-15_-14insT rrs_n.-15_-14insT 1 upstream_gene_variant 1471831 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1909 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1588 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.1500A>T rrs_n.1500A>T 1 non_coding_transcript_exon_variant 1473345 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1856 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.1507C>T rrs_n.1507C>T 1 non_coding_transcript_exon_variant 1473352 0 0 0 0 10 18 10358 15590 0.000964506172839506 0.000462612020337809 0.00177304351401163 0.998846745258841 0.998177970363271 0.999316369446418 0.357142857142857 0.186406660000445 0.559349687253333 NA NA NA 0 0 0.185301968137852 NA NA NA NA 1811 2512 False False 0.836176009954731 0.344721279219874 1.91137029518948 0 0 0.000356074788245403 0.998846745258841 0.998177970363271 0.999316369446418 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 6 17 7730 11857 0.00077559462254395 0.000284681048736677 0.00168737281383633 0.998568300488462 0.997708696799157 0.999165768038889 0.260869565217391 0.102286133915358 0.484051970402438 NA NA NA 0 0 0.195064322969093 NA NA NA NA 1499 2071 False False 0 0 0 0 0 0 0 0.541374324632828 0.174711118384 1.43990963645074 0 0 0.000477102121347592 0.998568300488462 0.997708696799157 0.999165768038889 96 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1519G>C rrs_n.1519G>C 1 non_coding_transcript_exon_variant 1473364 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.1523G>A rrs_n.1523G>A 1 non_coding_transcript_exon_variant 1473368 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2132 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Streptomycin rrs n.160dupT rrs_n.160dupT 1 non_coding_transcript_exon_variant 1472004 1 3 0 3 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.6429945931141 0.280491932584249 243 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 2 3) Uncertain significance No change no 1 +Streptomycin rrs n.165C>A rrs_n.165C>A 1 non_coding_transcript_exon_variant 1472010 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1886 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1568 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.16T>A rrs_n.16T>A 1 non_coding_transcript_exon_variant 1471861 0 0 0 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2101 2512 False False Inf 0.282736080598822 Inf 0 0 0.000355800035063835 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 3) Uncertain significance No change no 1 +Streptomycin rrs n.16T>C rrs_n.16T>C 1 non_coding_transcript_exon_variant 1471861 1 1 1 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0386035211949905 Inf 0.399114533205004 308.5 2512 False False Inf 0.282736080598822 Inf 9.64599209028648e-05 2.44215077354346e-06 0.000537321795461189 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1768 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 4 3) Uncertain significance No change no 1 +Streptomycin rrs n.170A>G rrs_n.170A>G 1 non_coding_transcript_exon_variant 1472015 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2085 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1740 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 1 3) Uncertain significance No change no 1 +Streptomycin rrs n.171C>G rrs_n.171C>G 1 non_coding_transcript_exon_variant 1472016 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.172C>T rrs_n.172C>T 1 non_coding_transcript_exon_variant 1472017 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1830 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1517 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 4 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.173G>T rrs_n.173G>T 1 non_coding_transcript_exon_variant 1472018 0 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2133 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1782 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.174G>T rrs_n.174G>T 1 non_coding_transcript_exon_variant 1472019 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.178G>A rrs_n.178G>A 1 non_coding_transcript_exon_variant 1472023 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.179G>C rrs_n.179G>C 1 non_coding_transcript_exon_variant 1472024 1 1 0 1 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 58.6596525903968 1 973.5 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 0 0 0.000355765720726338 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 59.8088564761233 1 806.5 2071 False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 0 0 0.000476793790149404 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.17T>G rrs_n.17T>G 1 non_coding_transcript_exon_variant 1471862 0 0 0 0 6 0 10362 15608 0.000578703703703703 0.000212402724453782 0.00125916554902567 1 0.99976368249849 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 1769 2512 False False Inf 1.77302352643969 Inf 0 0 0.000355937358633142 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 5 0 7731 11874 0.000646328852119958 0.0002098934625097 0.00150766595359595 1 0.999689379610589 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 1462 2071 False False 0 0 0 0 0 0 0 Inf 1.40693962335604 Inf 0 0 0.000477040423209609 1 0.999689379610589 1 15 3) Uncertain significance No change no 1 +Streptomycin rrs n.180A>C rrs_n.180A>C 1 non_coding_transcript_exon_variant 1472025 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1928 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1604 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.181C>G rrs_n.181C>G 1 non_coding_transcript_exon_variant 1472026 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.182C>G rrs_n.182C>G 1 non_coding_transcript_exon_variant 1472027 1 2 0 2 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.01513406993295 0.520321755085951 445 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.184C>A rrs_n.184C>A 1 non_coding_transcript_exon_variant 1472029 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1707 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1411 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.184C>T rrs_n.184C>T 1 non_coding_transcript_exon_variant 1472029 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.187G>A rrs_n.187G>A 1 non_coding_transcript_exon_variant 1472032 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 2 3) Uncertain significance No change no 1 +Streptomycin rrs n.-18C>T rrs_n.-18C>T 1 upstream_gene_variant 1471828 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1851 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1538 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.196C>T rrs_n.196C>T 1 non_coding_transcript_exon_variant 1472041 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 5 3) Uncertain significance No change no 1 +Streptomycin rrs n.-20_-19insTCCAAAGGGA rrs_n.-20_-19insTCCAAAGGGA 1 upstream_gene_variant 1471826 0 0 0 0 3 0 10365 15608 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 1 0.99976368249849 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2015 2512 False False Inf 0.622129167636411 Inf 0 0 0.000355834356021348 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.200T>A rrs_n.200T>A 1 non_coding_transcript_exon_variant 1472045 1 4 0 4 0 6 10368 15602 0 0 0.000355731413006942 0.999615581752947 0.999163472525571 0.999858912630967 0 0 0.4592581264399 0 0 0.602364635616474 0 0 0.4592581264399 0 0 2.28015540755431 0.155678943446982 141.5 2512 False False 0 0 1.27838118563185 0 0 0.000355731413006942 0.999615581752947 0.999163472525571 0.999858912630967 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 6 7736 11868 0 0 0.000476732171726368 0.999494694290045 0.998900489118281 0.999814539856352 0 0 0.4592581264399 0 0 0.602364635616474 0 0 0.4592581264399 0 0 2.32473819937431 0.158579244442435 134.5 2071 False False 0 0 0 0 0 0 0 0 0 1.30338194607257 0 0 0.000476732171726368 0.999494694290045 0.998900489118281 0.999814539856352 8 3) Uncertain significance No change no 1 +Streptomycin rrs n.201G>A rrs_n.201G>A 1 non_coding_transcript_exon_variant 1472046 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2022 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1683 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.204G>A rrs_n.204G>A 1 non_coding_transcript_exon_variant 1472049 0 0 0 0 5 0 10363 15608 0.000482253086419753 0.000156604214122162 0.00112505595550109 1 0.99976368249849 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 1689 2512 False False Inf 1.37979907306709 Inf 0 0 0.000355903017804084 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 5 0 7731 11874 0.000646328852119958 0.0002098934625097 0.00150766595359595 1 0.999689379610589 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 1396 2071 False False 0 0 0 0 0 0 0 Inf 1.40693962335604 Inf 0 0 0.000477040423209609 1 0.999689379610589 1 2 3) Uncertain significance No change no 1 +Streptomycin rrs n.205_206insT rrs_n.205_206insT 1 non_coding_transcript_exon_variant 1472050 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.212C>T rrs_n.212C>T 1 non_coding_transcript_exon_variant 1472057 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.213T>A rrs_n.213T>A 1 non_coding_transcript_exon_variant 1472058 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.213T>C rrs_n.213T>C 1 non_coding_transcript_exon_variant 1472058 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.213T>G rrs_n.213T>G 1 non_coding_transcript_exon_variant 1472058 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1921 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Streptomycin rrs n.217G>T rrs_n.217G>T 1 non_coding_transcript_exon_variant 1472062 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1690 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1397 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.222G>T rrs_n.222G>T 1 non_coding_transcript_exon_variant 1472067 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.236C>G rrs_n.236C>G 1 non_coding_transcript_exon_variant 1472081 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1929 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.239C>A rrs_n.239C>A 1 non_coding_transcript_exon_variant 1472084 0 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1900 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.-23C>T rrs_n.-23C>T 1 upstream_gene_variant 1471823 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.23T>C rrs_n.23T>C 1 non_coding_transcript_exon_variant 1471868 0 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1901 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1579 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 2 3) Uncertain significance No change no 1 +Streptomycin rrs n.23T>G rrs_n.23T>G 1 non_coding_transcript_exon_variant 1471868 1 1 1 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0386035211949905 Inf 0.399114533205004 308.5 2512 False False Inf 0.282736080598822 Inf 9.64599209028648e-05 2.44215077354346e-06 0.000537321795461189 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0393613144801391 Inf 0.394461726758121 237.5 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0.000129282482223658 3.27314370392442e-06 0.000720103058325324 1 0.999689379610589 1 2 3) Uncertain significance No change no 1 +Streptomycin rrs n.244C>T rrs_n.244C>T 1 non_coding_transcript_exon_variant 1472089 0 0 0 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1781 2512 False False Inf 0.282736080598822 Inf 0 0 0.000355800035063835 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.24G>A rrs_n.24G>A 1 non_coding_transcript_exon_variant 1471869 0 0 0 0 3 0 10365 15608 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 1 0.99976368249849 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1857 2512 False False Inf 0.622129167636411 Inf 0 0 0.000355834356021348 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 7733 11874 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 1 0.999689379610589 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1542 2071 False False 0 0 0 0 0 0 0 Inf 0.634338273987677 Inf 0 0 0.000476917074793532 1 0.999689379610589 1 2 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.259dupG rrs_n.259dupG 1 non_coding_transcript_exon_variant 1472100 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2069 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Streptomycin rrs n.-25C>A rrs_n.-25C>A 1 upstream_gene_variant 1471821 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1748 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1445 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.-25delC rrs_n.-25delC 1 upstream_gene_variant 1471820 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.261G>A rrs_n.261G>A 1 non_coding_transcript_exon_variant 1472106 0 0 0 0 2 2 10366 15606 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999871860584315 0.999537193839207 0.999984481345552 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1887 2512 False False 1.50549874590005 0.10909391082996 20.7696540777406 0 0 0.000355800035063835 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 2 7734 11872 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999831564763348 0.99939168785815 0.999979601060482 0.5 0.067585986488543 0.932414013511457 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1569 2071 False False 0 0 0 0 0 0 0 1.53504008275148 0.111228967362952 21.1783159842378 0 0 0.000476855424503066 0.999831564763348 0.99939168785815 0.999979601060482 70 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.263C>A rrs_n.263C>A 1 non_coding_transcript_exon_variant 1472108 1 1 0 1 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 58.6540000158548 1 973.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 59.801132462225 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 4 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.263C>T rrs_n.263C>T 1 non_coding_transcript_exon_variant 1472108 0 0 0 0 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1990 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 0 0 0.000355765720726338 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1657 2071 False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 0 0 0.000476793790149404 0.999831564763348 0.99939168785815 0.999979601060482 72 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.266C>T rrs_n.266C>T 1 non_coding_transcript_exon_variant 1472111 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1946 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1621 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 1 3) Uncertain significance No change no 1 +Streptomycin rrs n.267C>T rrs_n.267C>T 1 non_coding_transcript_exon_variant 1472112 0 0 0 0 4 5 10364 15603 0.000385802469135802 0.000105127872737001 0.000987510251175401 0.999679651460789 0.999252573060182 0.999895975781355 0.444444444444444 0.136995662265166 0.787991493221131 NA NA NA 0 0 0.521823750104981 NA NA NA NA 2023 2512 False False 1.20439984561945 0.238927818072029 5.59645851293522 0 0 0.000355868683600791 0.999679651460789 0.999252573060182 0.999895975781355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 5 7732 11869 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.999578911908371 0.999017596768841 0.999863260157969 0.444444444444444 0.136995662265166 0.787991493221131 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1684 2071 False False 0 0 0 0 0 0 0 1.22803931712364 0.243597035514314 5.70658237719251 0 0 0.000476978741026985 0.999578911908371 0.999017596768841 0.999863260157969 23 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.268T>C rrs_n.268T>C 1 non_coding_transcript_exon_variant 1472113 0 0 0 0 3 5 10365 15603 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999679651460789 0.999252573060182 0.999895975781355 0.375 0.0852334141372535 0.755136783633448 NA NA NA 0 0 0.521823750104981 NA NA NA NA 2117 2512 False False 0.903212735166425 0.140213309764784 4.64350502715881 0 0 0.000355834356021348 0.999679651460789 0.999252573060182 0.999895975781355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 4 7733 11870 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 0.999663129526697 0.999137704464366 0.999908206750254 0.428571428571428 0.0989882784425078 0.815948432359917 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1769 2071 False False 0 0 0 0 0 0 0 1.15123496702444 0.168586646422245 6.80694398225105 0 0 0.000476917074793532 0.999663129526697 0.999137704464366 0.999908206750254 19 3) Uncertain significance No change no 1 +Streptomycin rrs n.269A>G rrs_n.269A>G 1 non_coding_transcript_exon_variant 1472114 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.270C>T rrs_n.270C>T 1 non_coding_transcript_exon_variant 1472115 1 2 0 2 2 2 10366 15606 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999871860584315 0.999537193839207 0.999984481345552 0.5 0.067585986488543 0.932414013511457 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01719423016258 0.52034662480125 555 2512 False False 1.50549874590005 0.10909391082996 20.7696540777406 0 0 0.000355800035063835 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 7734 11873 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999915782381674 0.999530859783396 0.999997867796783 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 59.821615810862 1 806.5 2071 False False 0 0 0 0 0 0 0 3.07033876389966 0.159799628612092 180.959738606129 0 0 0.000476855424503066 0.999915782381674 0.999530859783396 0.999997867796783 6 3) Uncertain significance No change no 1 +Streptomycin rrs n.272A>G rrs_n.272A>G 1 non_coding_transcript_exon_variant 1472117 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.276C>T rrs_n.276C>T 1 non_coding_transcript_exon_variant 1472121 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2024 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1685 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance No change no 1 +Streptomycin rrs n.277G>A rrs_n.277G>A 1 non_coding_transcript_exon_variant 1472122 0 0 0 0 1 6 10367 15602 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999615581752947 0.999163472525571 0.999858912630967 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1812 2512 False False 0.250827947654416 0.00545680578940276 2.0680301831463 0 0 0.000355765720726338 0.999615581752947 0.999163472525571 0.999858912630967 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 6 7735 11868 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999494694290045 0.998900489118281 0.999814539856352 0.142857142857142 0.00361029686190058 0.578723197043195 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1500 2071 False False 0 0 0 0 0 0 0 0.255720749838396 0.00556297279916227 2.10858771426871 0 0 0.000476793790149404 0.999494694290045 0.998900489118281 0.999814539856352 2 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.279C>A rrs_n.279C>A 1 non_coding_transcript_exon_variant 1472124 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.-27C>A rrs_n.-27C>A 1 upstream_gene_variant 1471819 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2030 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Streptomycin rrs n.280G>T rrs_n.280G>T 1 non_coding_transcript_exon_variant 1472125 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.282C>T rrs_n.282C>T 1 non_coding_transcript_exon_variant 1472127 0 0 0 0 7 11 10361 15597 0.000675154320987654 0.000271488767107418 0.00139057803317028 0.999295233213736 0.998739328260189 0.999648132128855 0.388888888888888 0.172985854789751 0.642548794106937 NA NA NA 0 0 0.284914152918154 NA NA NA NA 1991 2512 False False 0.957954216423476 0.314764531957671 2.70713869290272 0 0 0.000355971706089883 0.999295233213736 0.998739328260189 0.999648132128855 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 6 11 7730 11863 0.00077559462254395 0.000284681048736677 0.00168737281383633 0.999073606198416 0.998343031567643 0.999537459717592 0.352941176470588 0.14209748311022 0.616716336556597 NA NA NA 0 0 0.284914152918154 NA NA NA NA 1658 2071 False False 0 0 0 0 0 0 0 0.837092790779724 0.254085324765121 2.4706054422472 0 0 0.000477102121347592 0.999073606198416 0.998343031567643 0.999537459717592 34 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.284G>C rrs_n.284G>C 1 non_coding_transcript_exon_variant 1472129 0 0 0 0 7 11 10361 15597 0.000675154320987654 0.000271488767107418 0.00139057803317028 0.999295233213736 0.998739328260189 0.999648132128855 0.388888888888888 0.172985854789751 0.642548794106937 NA NA NA 0 0 0.284914152918154 NA NA NA NA 2158 2512 False False 0.957954216423476 0.314764531957671 2.70713869290272 0 0 0.000355971706089883 0.999295233213736 0.998739328260189 0.999648132128855 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 6 11 7730 11863 0.00077559462254395 0.000284681048736677 0.00168737281383633 0.999073606198416 0.998343031567643 0.999537459717592 0.352941176470588 0.14209748311022 0.616716336556597 NA NA NA 0 0 0.284914152918154 NA NA NA NA 1804 2071 False False 0 0 0 0 0 0 0 0.837092790779724 0.254085324765121 2.4706054422472 0 0 0.000477102121347592 0.999073606198416 0.998343031567643 0.999537459717592 30 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.287A>G rrs_n.287A>G 1 non_coding_transcript_exon_variant 1472132 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1846 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1534 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.292G>A rrs_n.292G>A 1 non_coding_transcript_exon_variant 1472137 0 0 0 0 10 15 10358 15593 0.000964506172839506 0.000462612020337809 0.00177304351401163 0.999038954382368 0.998415396005541 0.999462013453075 0.4 0.211254806465142 0.61334650374316 NA NA NA 0 0 0.218019360910534 NA NA NA NA 1930 2512 False False 1.0036042994143 0.403019853923277 2.38905887332637 0 0 0.000356074788245403 0.999038954382368 0.998415396005541 0.999462013453075 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 8 15 7728 11859 0.00103412616339193 0.000446564649135067 0.00203661849802302 0.998736735725113 0.997917292278642 0.999292793629768 0.347826086956521 0.163763598374949 0.572656036963505 NA NA NA 0 0 0.218019360910534 NA NA NA NA 1605 2071 False False 0 0 0 0 0 0 0 0.818426501035196 0.300363906996637 2.05754599527714 0 0 0.000477225565514406 0.998736735725113 0.997917292278642 0.999292793629768 70 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.298_299insT rrs_n.298_299insT 1 non_coding_transcript_exon_variant 1472143 0 0 0 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1831 2512 False False Inf 0.282736080598822 Inf 0 0 0.000355800035063835 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1518 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0 0 0.000476855424503066 1 0.999689379610589 1 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.300_301insT rrs_n.300_301insT 1 non_coding_transcript_exon_variant 1472145 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1871 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1553 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.303T>C rrs_n.303T>C 1 non_coding_transcript_exon_variant 1472148 0 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1691 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1398 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 9 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.304_305dupGT rrs_n.304_305dupGT 1 non_coding_transcript_exon_variant 1472146 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1753 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1449 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.304G>A rrs_n.304G>A 1 non_coding_transcript_exon_variant 1472149 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1847 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1535 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.305T>A rrs_n.305T>A 1 non_coding_transcript_exon_variant 1472150 0 0 0 0 11 19 10357 15589 0.00106095679012345 0.000529741017552837 0.00189754996565939 0.998782675550999 0.998099646955 0.999266937052498 0.366666666666666 0.199298625012034 0.561440150988042 NA NA NA 0 0 0.176466911806965 NA NA NA NA 1799 2512 False False 0.871411656494717 0.374479709895801 1.92783988195965 0 0 0.000356109162232076 0.998782675550999 0.998099646955 0.999266937052498 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 9 19 7727 11855 0.00116339193381592 0.000532110502771461 0.00220732634615895 0.99839986525181 0.997502314270442 0.999036348042965 0.321428571428571 0.158776037886153 0.523516406709618 NA NA NA 0 0 0.176466911806965 NA NA NA NA 1488 2071 False False 0 0 0 0 0 0 0 0.726740819954636 0.289397913464502 1.68674689458957 0 0 0.00047728731155563 0.99839986525181 0.997502314270442 0.999036348042965 196 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.306C>A rrs_n.306C>A 1 non_coding_transcript_exon_variant 1472151 0 0 0 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1737 2512 False False Inf 0.282736080598822 Inf 0 0 0.000355800035063835 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1435 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0 0 0.000476855424503066 1 0.999689379610589 1 13 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.306C>T rrs_n.306C>T 1 non_coding_transcript_exon_variant 1472151 1 1 0 1 8 17 10360 15591 0.000771604938271604 0.00033318123262376 0.00151980017311994 0.998910814966683 0.998256680139026 0.999365385605091 0.32 0.149495422613569 0.535000717497372 0 0 0.975 0 0 0.195064322969093 0 0 58.6428865599394 1 610 2512 False False 0.708198955257778 0.26444994965303 1.73218043351567 0 0 0.000356006060176228 0.998910814966683 0.998256680139026 0.999365385605091 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 6 16 7730 11858 0.00077559462254395 0.000284681048736677 0.00168737281383633 0.998652518106788 0.997812693726175 0.999229607694274 0.272727272727272 0.107289248370397 0.502221201266349 NA NA NA 0 0 0.205907214207822 NA NA NA NA 1580 2071 False False 0 0 0 0 0 0 0 0.57525873221216 0.184288530049547 1.54859749226854 0 0 0.000477102121347592 0.998652518106788 0.997812693726175 0.999229607694274 61 3) Uncertain significance No change no 1 +Streptomycin rrs n.307C>T rrs_n.307C>T 1 non_coding_transcript_exon_variant 1472152 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1888 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1570 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.314A>G rrs_n.314A>G 1 non_coding_transcript_exon_variant 1472159 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.315C>T rrs_n.315C>T 1 non_coding_transcript_exon_variant 1472160 0 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2070 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1726 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 52 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.319G>A rrs_n.319G>A 1 non_coding_transcript_exon_variant 1472164 0 0 0 0 5 9 10363 15599 0.000482253086419753 0.000156604214122162 0.00112505595550109 0.99942337262942 0.998905665124108 0.999736296428239 0.357142857142857 0.127598429859159 0.648619889384008 NA NA NA 0 0 0.336267116879942 NA NA NA NA 2086 2512 False False 0.836255052698167 0.22009840118957 2.77947093098883 0 0 0.000355903017804084 0.99942337262942 0.998905665124108 0.999736296428239 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 9 7732 11865 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.999242041435068 0.998561648359028 0.999653356368186 0.307692307692307 0.0909203945720966 0.614261661750705 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1741 2071 False False 0 0 0 0 0 0 0 0.682014140369029 0.153421017946502 2.44469827824845 0 0 0.000476978741026985 0.999242041435068 0.998561648359028 0.999653356368186 6 3) Uncertain significance No change no 1 +Streptomycin rrs n.324A>C rrs_n.324A>C 1 non_coding_transcript_exon_variant 1472169 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1975 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1643 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.327T>C rrs_n.327T>C 1 non_coding_transcript_exon_variant 1472172 0 0 0 0 18 35 10350 15573 0.00173611111111111 0.00102924387949825 0.00274242148457404 0.997757560225525 0.996882675820933 0.998437576741528 0.339622641509433 0.215199637947462 0.482669306459369 NA NA NA 0 0 0.100032435572105 NA NA NA NA 1848 2512 False False 0.773813664596273 0.412355293202957 1.40469782605841 0 0 0.000356349966090498 0.997757560225525 0.996882675820933 0.998437576741528 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 14 35 7722 11839 0.00180972078593588 0.000989733300678632 0.0030345415962221 0.997052383358598 0.995902940412603 0.997946044347525 0.285714285714285 0.165841791654581 0.432629719646493 NA NA NA 0 0 0.100032435572105 NA NA NA NA 1536 2071 False False 0 0 0 0 0 0 0 0.613260813260813 0.304588750654523 1.16998943243023 0 0 0.000477596281588063 0.997052383358598 0.995902940412603 0.997946044347525 190 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.32A>G rrs_n.32A>G 1 non_coding_transcript_exon_variant 1471877 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2054 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1713 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 4 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.-32T>G rrs_n.-32T>G 1 upstream_gene_variant 1471814 0 0 0 0 4 0 10364 15608 0.000385802469135802 0.000105127872737001 0.000987510251175401 1 0.99976368249849 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 2048 2512 False False Inf 0.993868422549659 Inf 0 0 0.000355868683600791 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 0 7732 11874 0.000517063081695967 0.000140899683864147 0.00132335286075948 1 0.999689379610589 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 1707 2071 False False 0 0 0 0 0 0 0 Inf 1.01342344657205 Inf 0 0 0.000476978741026985 1 0.999689379610589 1 1 3) Uncertain significance No change no 1 +Streptomycin rrs n.330G>T rrs_n.330G>T 1 non_coding_transcript_exon_variant 1472175 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.332C>T rrs_n.332C>T 1 non_coding_transcript_exon_variant 1472177 0 0 0 0 5 10 10363 15598 0.000482253086419753 0.000156604214122162 0.00112505595550109 0.999359302921578 0.998822051949738 0.999692719453314 0.333333333333333 0.11824110336688 0.616196267458845 NA NA NA 0 0 0.30849710781876 NA NA NA NA 1976 2512 False False 0.752581298851683 0.201781230460037 2.41739213960686 0 0 0.000355903017804084 0.999359302921578 0.998822051949738 0.999692719453314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 10 7732 11864 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.999157823816742 0.998451755191613 0.9995960722577 0.285714285714285 0.0838893183071275 0.581035257183661 NA NA NA 0 0 0.30849710781876 NA NA NA NA 1644 2071 False False 0 0 0 0 0 0 0 0.613760993274702 0.14045294063066 2.12901862852369 0 0 0.000476978741026985 0.999157823816742 0.998451755191613 0.9995960722577 11 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.333C>T rrs_n.333C>T 1 non_coding_transcript_exon_variant 1472178 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.336G>A rrs_n.336G>A 1 non_coding_transcript_exon_variant 1472181 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1931 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1606 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.338C>G rrs_n.338C>G 1 non_coding_transcript_exon_variant 1472183 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2071 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1727 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.33C>T rrs_n.33C>T 1 non_coding_transcript_exon_variant 1471878 0 0 0 0 4 7 10364 15601 0.000385802469135802 0.000105127872737001 0.000987510251175401 0.999551512045105 0.999076163117038 0.999819666176692 0.363636363636363 0.109263443819098 0.692095284988322 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1959 2512 False False 0.860175332193857 0.184612886649235 3.38458769855359 0 0 0.000355868683600791 0.999551512045105 0.999076163117038 0.999819666176692 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 7 7732 11867 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.999410476671719 0.998785736251934 0.999762949244471 0.363636363636363 0.109263443819098 0.692095284988322 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1630 2071 False False 0 0 0 0 0 0 0 0.877023132067105 0.188211137329044 3.45123068737998 0 0 0.000476978741026985 0.999410476671719 0.998785736251934 0.999762949244471 18 3) Uncertain significance No change no 1 +Streptomycin rrs n.340C>T rrs_n.340C>T 1 non_coding_transcript_exon_variant 1472185 0 0 0 0 4 0 10364 15608 0.000385802469135802 0.000105127872737001 0.000987510251175401 1 0.99976368249849 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 1992 2512 False False Inf 0.993868422549659 Inf 0 0 0.000355868683600791 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 7733 11874 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 1 0.999689379610589 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1659 2071 False False 0 0 0 0 0 0 0 Inf 0.634338273987677 Inf 0 0 0.000476917074793532 1 0.999689379610589 1 1 3) Uncertain significance No change no 1 +Streptomycin rrs n.349G>A rrs_n.349G>A 1 non_coding_transcript_exon_variant 1472194 1 2 0 2 0 7 10368 15601 0 0 0.000355731413006942 0.999551512045105 0.999076163117038 0.999819666176692 0 0 0.409616397225003 0 0 0.841886116991581 0 0 0.409616397225003 0 0 8.01307976134894 0.520296959878844 429 2512 False False 0 0 1.04426933597617 0 0 0.000355731413006942 0.999551512045105 0.999076163117038 0.999819666176692 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 6 7736 11868 0 0 0.000476732171726368 0.999494694290045 0.998900489118281 0.999814539856352 0 0 0.4592581264399 0 0 0.841886116991581 0 0 0.4592581264399 0 0 8.16998947578329 0.52220529693831 350 2071 False False 0 0 0 0 0 0 0 0 0 1.30338194607257 0 0 0.000476732171726368 0.999494694290045 0.998900489118281 0.999814539856352 3 3) Uncertain significance No change no 1 +Streptomycin rrs n.358G>A rrs_n.358G>A 1 non_coding_transcript_exon_variant 1472203 0 0 0 0 10 19 10358 15589 0.000964506172839506 0.000462612020337809 0.00177304351401163 0.998782675550999 0.998099646955 0.999266937052498 0.344827586206896 0.179383649235111 0.543305727667943 NA NA NA 0 0 0.176466911806965 NA NA NA NA 1813 2512 False False 0.79211593378116 0.328841516503485 1.7913391517901 0 0 0.000356074788245403 0.998782675550999 0.998099646955 0.999266937052498 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 7 19 7729 11855 0.000904860392967942 0.000363875741427306 0.00186346392020999 0.99839986525181 0.997502314270442 0.999036348042965 0.269230769230769 0.115732213291504 0.477874789693831 NA NA NA 0 0 0.176466911806965 NA NA NA NA 1501 2071 False False 0 0 0 0 0 0 0 0.565096594507357 0.20065250601631 1.40471067662588 0 0 0.000477163835447126 0.99839986525181 0.997502314270442 0.999036348042965 94 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.-35A>G rrs_n.-35A>G 1 upstream_gene_variant 1471811 1 14 1 13 4 13 10364 15595 0.000385802469135802 0.000105127872737001 0.000987510251175401 0.999167093798052 0.998576126182689 0.999556440358575 0.235294117647058 0.0681077404373566 0.49899327320458 0.0714285714285714 0.00180678065912538 0.338684489931821 0.0714285714285714 0.00180678065912538 0.338684489931821 0.115748300329543 0.00272756981371541 0.77088873587993 0.0120479623584685 71 2512 False False 0.462993201318172 0.10994174099948 1.49924520615376 9.64785335262904e-05 2.44262200321851e-06 0.000537425452634802 0.999167093798052 0.998576126182689 0.999556440358575 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 14 1 13 4 13 7732 11861 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.998905170961765 0.998128536682641 0.999416924941029 0.235294117647058 0.0681077404373566 0.49899327320458 0.0714285714285714 0.00180678065912538 0.338684489931821 0.0714285714285714 0.00180678065912538 0.338684489931821 0.118001114250467 0.00278047366679351 0.785979616426427 0.0124275116126396 59 2071 False False 0 0 0 0 0 0 0 0.47200445700187 0.112073032823122 1.52860257516419 0.000129315918789603 3.27399024170944e-06 0.000720289244853199 0.998905170961765 0.998128536682641 0.999416924941029 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.365A>C rrs_n.365A>C 1 non_coding_transcript_exon_variant 1472210 0 0 0 0 5 8 10363 15600 0.000482253086419753 0.000156604214122162 0.00112505595550109 0.999487442337262 0.998990308225149 0.99977868883794 0.384615384615384 0.13857933889016 0.684222397085936 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1858 2512 False False 0.940847245006272 0.242121776120969 3.26282595837012 0 0 0.000355903017804084 0.999487442337262 0.998990308225149 0.99977868883794 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 8 7732 11866 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.999326259053394 0.998672895689377 0.999709083033384 0.333333333333333 0.0992460911495833 0.651124493581186 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1543 2071 False False 0 0 0 0 0 0 0 0.767330574236937 0.169034015048489 2.86517783020669 0 0 0.000476978741026985 0.999326259053394 0.998672895689377 0.999709083033384 12 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.365A>G rrs_n.365A>G 1 non_coding_transcript_exon_variant 1472210 0 0 0 0 2 1 10366 15607 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999935930292158 0.99964307871082 0.999998377896754 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 2055 2512 False False 3.01119043025274 0.156729426968348 177.474331043773 0 0 0.000355800035063835 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Streptomycin rrs n.368G>C rrs_n.368G>C 1 non_coding_transcript_exon_variant 1472213 0 0 0 0 5 8 10363 15600 0.000482253086419753 0.000156604214122162 0.00112505595550109 0.999487442337262 0.998990308225149 0.99977868883794 0.384615384615384 0.13857933889016 0.684222397085936 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1724 2512 False False 0.940847245006272 0.242121776120969 3.26282595837012 0 0 0.000355903017804084 0.999487442337262 0.998990308225149 0.99977868883794 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 8 7732 11866 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.999326259053394 0.998672895689377 0.999709083033384 0.333333333333333 0.0992460911495833 0.651124493581186 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1425 2071 False False 0 0 0 0 0 0 0 0.767330574236937 0.169034015048489 2.86517783020669 0 0 0.000476978741026985 0.999326259053394 0.998672895689377 0.999709083033384 33 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.369C>G rrs_n.369C>G 1 non_coding_transcript_exon_variant 1472214 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1977 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 10 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.370A>G rrs_n.370A>G 1 non_coding_transcript_exon_variant 1472215 0 0 0 0 6 7 10362 15601 0.000578703703703703 0.000212402724453782 0.00125916554902567 0.999551512045105 0.999076163117038 0.999819666176692 0.461538461538461 0.192232441801288 0.748654517729696 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1814 2512 False False 1.29051203573496 0.35818336434294 4.48595644399191 0 0 0.000355937358633142 0.999551512045105 0.999076163117038 0.999819666176692 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 5 7 7731 11867 0.000646328852119958 0.0002098934625097 0.00150766595359595 0.999410476671719 0.998785736251934 0.999762949244471 0.416666666666666 0.15165222980843 0.723330314317894 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1502 2071 False False 0 0 0 0 0 0 0 1.0964207180738 0.274287483368725 4.01478723207519 0 0 0.000477040423209609 0.999410476671719 0.998785736251934 0.999762949244471 9 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.377G>A rrs_n.377G>A 1 non_coding_transcript_exon_variant 1472222 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1889 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1571 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 20 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.378C>G rrs_n.378C>G 1 non_coding_transcript_exon_variant 1472223 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1725 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1426 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 2 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.37C>T rrs_n.37C>T 1 non_coding_transcript_exon_variant 1471882 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.380C>A rrs_n.380C>A 1 non_coding_transcript_exon_variant 1472225 0 0 0 0 6 9 10362 15599 0.000578703703703703 0.000212402724453782 0.00125916554902567 0.99942337262942 0.998905665124108 0.999736296428239 0.4 0.163364323859513 0.677130233793718 NA NA NA 0 0 0.336267116879942 NA NA NA NA 2039 2512 False False 1.0036029080615 0.293857261692086 3.15841575964045 0 0 0.000355937358633142 0.99942337262942 0.998905665124108 0.999736296428239 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 6 9 7730 11865 0.00077559462254395 0.000284681048736677 0.00168737281383633 0.999242041435068 0.998561648359028 0.999653356368186 0.4 0.163364323859513 0.677130233793718 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1699 2071 False False 0 0 0 0 0 0 0 1.02328589909443 0.299562273515437 3.22060276670201 0 0 0.000477102121347592 0.999242041435068 0.998561648359028 0.999653356368186 77 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.382A>C rrs_n.382A>C 1 non_coding_transcript_exon_variant 1472227 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2007 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1669 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.383G>C rrs_n.383G>C 1 non_coding_transcript_exon_variant 1472228 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1708 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1412 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 2 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.384C>T rrs_n.384C>T 1 non_coding_transcript_exon_variant 1472229 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1738 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1436 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 18 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.389T>C rrs_n.389T>C 1 non_coding_transcript_exon_variant 1472234 0 0 0 0 5 5 10363 15603 0.000482253086419753 0.000156604214122162 0.00112505595550109 0.999679651460789 0.999252573060182 0.999895975781355 0.5 0.187086028447398 0.812913971552601 NA NA NA 0 0 0.521823750104981 NA NA NA NA 2040 2512 False False 1.50564508347003 0.346416577088828 6.54429148454004 0 0 0.000355903017804084 0.999679651460789 0.999252573060182 0.999895975781355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 5 5 7731 11869 0.000646328852119958 0.0002098934625097 0.00150766595359595 0.999578911908371 0.999017596768841 0.999863260157969 0.5 0.187086028447398 0.812913971552601 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1700 2071 False False 0 0 0 0 0 0 0 1.53524770404863 0.353193442627102 6.67365752588487 0 0 0.000477040423209609 0.999578911908371 0.999017596768841 0.999863260157969 8 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.38G>A rrs_n.38G>A 1 non_coding_transcript_exon_variant 1471883 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1754 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.390G>C rrs_n.390G>C 1 non_coding_transcript_exon_variant 1472235 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1960 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 8 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.391C>G rrs_n.391C>G 1 non_coding_transcript_exon_variant 1472236 0 0 0 0 4 5 10364 15603 0.000385802469135802 0.000105127872737001 0.000987510251175401 0.999679651460789 0.999252573060182 0.999895975781355 0.444444444444444 0.136995662265166 0.787991493221131 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1709 2512 False False 1.20439984561945 0.238927818072029 5.59645851293522 0 0 0.000355868683600791 0.999679651460789 0.999252573060182 0.999895975781355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 5 7732 11869 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.999578911908371 0.999017596768841 0.999863260157969 0.444444444444444 0.136995662265166 0.787991493221131 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1413 2071 False False 0 0 0 0 0 0 0 1.22803931712364 0.243597035514314 5.70658237719251 0 0 0.000476978741026985 0.999578911908371 0.999017596768841 0.999863260157969 23 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.392A>G rrs_n.392A>G 1 non_coding_transcript_exon_variant 1472237 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.395G>A rrs_n.395G>A 1 non_coding_transcript_exon_variant 1472240 0 0 0 0 5 5 10363 15603 0.000482253086419753 0.000156604214122162 0.00112505595550109 0.999679651460789 0.999252573060182 0.999895975781355 0.5 0.187086028447398 0.812913971552601 NA NA NA 0 0 0.521823750104981 NA NA NA NA 2025 2512 False False 1.50564508347003 0.346416577088828 6.54429148454004 0 0 0.000355903017804084 0.999679651460789 0.999252573060182 0.999895975781355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 5 5 7731 11869 0.000646328852119958 0.0002098934625097 0.00150766595359595 0.999578911908371 0.999017596768841 0.999863260157969 0.5 0.187086028447398 0.812913971552601 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1686 2071 False False 0 0 0 0 0 0 0 1.53524770404863 0.353193442627102 6.67365752588487 0 0 0.000477040423209609 0.999578911908371 0.999017596768841 0.999863260157969 32 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.395G>C rrs_n.395G>C 1 non_coding_transcript_exon_variant 1472240 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2056 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.397C>T rrs_n.397C>T 1 non_coding_transcript_exon_variant 1472242 1 1 0 1 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 58.6540000158548 1 973.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 10 3) Uncertain significance No change no 1 +Streptomycin rrs n.-40_-39insA rrs_n.-40_-39insA 1 upstream_gene_variant 1471806 1 1 0 1 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 58.6596525903968 1 973.5 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 0 0 0.000355765720726338 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 59.8138891519084 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance No change no 1 +Streptomycin rrs n.406G>A rrs_n.406G>A 1 non_coding_transcript_exon_variant 1472251 0 0 0 0 2 5 10366 15603 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999679651460789 0.999252573060182 0.999895975781355 0.285714285714285 0.0366925661760855 0.709579136262657 NA NA NA 0 0 0.521823750104981 NA NA NA NA 2057 2512 False False 0.602083735288443 0.0572994001432256 3.67859568857157 0 0 0.000355800035063835 0.999679651460789 0.999252573060182 0.999895975781355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 4 7734 11870 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999663129526697 0.999137704464366 0.999908206750254 0.333333333333333 0.0432718682927417 0.777221904496487 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1714 2071 False False 0 0 0 0 0 0 0 0.767390742177398 0.0693820092373707 5.35625075908251 0 0 0.000476855424503066 0.999663129526697 0.999137704464366 0.999908206750254 147 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.408G>T rrs_n.408G>T 1 non_coding_transcript_exon_variant 1472253 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2145 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 10 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.414C>A rrs_n.414C>A 1 non_coding_transcript_exon_variant 1472259 1 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1782 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1473 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 41 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.415G>A rrs_n.415G>A 1 non_coding_transcript_exon_variant 1472260 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance No change no 1 +Streptomycin rrs n.421C>A rrs_n.421C>A 1 non_coding_transcript_exon_variant 1472266 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1993 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.43C>G rrs_n.43C>G 1 non_coding_transcript_exon_variant 1471888 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1755 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1450 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.43C>T rrs_n.43C>T 1 non_coding_transcript_exon_variant 1471888 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.440A>G rrs_n.440A>G 1 non_coding_transcript_exon_variant 1472285 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2118 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Streptomycin rrs n.444T>G rrs_n.444T>G 1 non_coding_transcript_exon_variant 1472289 1 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1947 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1622 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 6 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.445C>G rrs_n.445C>G 1 non_coding_transcript_exon_variant 1472290 1 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1710 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1414 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 7 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.447A>G rrs_n.447A>G 1 non_coding_transcript_exon_variant 1472292 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance No change no 1 +Streptomycin rrs n.448C>T rrs_n.448C>T 1 non_coding_transcript_exon_variant 1472293 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1948 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1623 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.453_470delGTCCGGGTTCTCTCGGATinsCTAACG rrs_n.453_470delGTCCGGGTTCTCTCGGATinsCTAACG 1 non_coding_transcript_exon_variant 1472298 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1756 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1451 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.454T>C rrs_n.454T>C 1 non_coding_transcript_exon_variant 1472299 1 1 0 1 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 58.6540000158548 1 973.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 59.801132462225 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 1 3) Uncertain significance No change no 1 +Streptomycin rrs n.459G>A rrs_n.459G>A 1 non_coding_transcript_exon_variant 1472304 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1815 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1503 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.45G>A rrs_n.45G>A 1 non_coding_transcript_exon_variant 1471890 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2119 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1770 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.462C>T rrs_n.462C>T 1 non_coding_transcript_exon_variant 1472307 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 1 3) Uncertain significance No change no 1 +Streptomycin rrs n.466C>T rrs_n.466C>T 1 non_coding_transcript_exon_variant 1472311 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.469_476dupATTGACGG rrs_n.469_476dupATTGACGG 1 non_coding_transcript_exon_variant 1472310 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1783 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1474 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.479G>C rrs_n.479G>C 1 non_coding_transcript_exon_variant 1472324 1 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2072 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1728 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 7 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.47G>A rrs_n.47G>A 1 non_coding_transcript_exon_variant 1471892 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 10 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.480G>C rrs_n.480G>C 1 non_coding_transcript_exon_variant 1472325 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2026 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1687 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 6 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.481dupT rrs_n.481dupT 1 non_coding_transcript_exon_variant 1472325 0 0 0 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2041 2512 False False Inf 0.282736080598822 Inf 0 0 0.000355800035063835 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.483G>C rrs_n.483G>C 1 non_coding_transcript_exon_variant 1472328 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1739 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1437 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 7 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.484A>T rrs_n.484A>T 1 non_coding_transcript_exon_variant 1472329 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1770 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1463 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.492C>T rrs_n.492C>T 1 non_coding_transcript_exon_variant 1472337 0 0 0 0 81 571 10287 15037 0.0078125 0.00620895432634906 0.00970099889838493 0.963416196822142 0.960351215741433 0.966306858907566 0.124233128834355 0.0998956223947559 0.152030710237448 NA NA NA 0 0 0.00643956091663975 NA NA NA NA NA NA False True 0.20735827461147 0.162014769269793 0.262464492888882 0 0 0.000358531945565023 0.963416196822142 0.960351215741433 0.966306858907566 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 43 381 7693 11493 0.00555842812823164 0.00402549635194972 0.00747994085994441 0.967913087417887 0.964584256164624 0.97100984657476 0.101415094339622 0.0743709677797711 0.13416984986232 NA NA NA 0 0 0.00963537769705558 NA NA NA NA NA NA False True 0 0 0 0 0 1 0 0.168609155884631 0.119881848386243 0.231892380519606 0 0 0.00047939622592025 0.967913087417887 0.964584256164624 0.97100984657476 558 Not assoc w R Previous WHO guidance 4) Not assoc w R - Interim DOWN from NotAwR to NotAwRI yes Prev. WHO 3 +Streptomycin rrs n.493A>G rrs_n.493A>G 1 non_coding_transcript_exon_variant 1472338 0 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2134 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1783 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 13 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.499C>T rrs_n.499C>T 1 non_coding_transcript_exon_variant 1472344 1 1 0 1 10 14 10358 15594 0.000964506172839506 0.000462612020337809 0.00177304351401163 0.99910302409021 0.99849548434986 0.999509530910458 0.416666666666666 0.221096905346678 0.633569354343637 0 0 0.975 0 0 0.231635761650116 0 0 58.6654744854147 1 973.5 2512 False False 1.07535928061125 0.427173109188819 2.60418457705178 0 0 0.000356074788245403 0.99910302409021 0.99849548434986 0.999509530910458 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 9 14 7727 11860 0.00116339193381592 0.000532110502771461 0.00220732634615895 0.998820953343439 0.9980225505579 0.99935525904558 0.391304347826087 0.197076423969014 0.61458104261115 0 0 0.975 0 0 0.231635761650116 0 0 59.8102659119996 1 806.5 2071 False False 0 0 0 0 0 0 0 0.986707093863817 0.376518776148696 2.44882726685889 0 0 0.00047728731155563 0.998820953343439 0.9980225505579 0.99935525904558 82 3) Uncertain significance No change no 1 +Streptomycin rrs n.-4T>G rrs_n.-4T>G 1 upstream_gene_variant 1471842 1 36 0 36 1 49 10367 15559 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.996860584315735 0.995851625031694 0.997676567865288 0.02 0.000506227983040829 0.106469545711499 0 0 0.0973937559144919 0 0 0.0725192636642774 0 0 0.162011252459306 1.19939224834577e-08 17 2512 True False 0.0306289777413811 0.000764599146126081 0.178899727542062 0 0 0.000355765720726338 0.996860584315735 0.995851625031694 0.997676567865288 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 24 0 24 1 32 7735 11842 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.997305036213576 0.99619762638504 0.99815593879969 0.0303030303030303 0.000766912075048109 0.157593972272496 0 0 0.142473597722525 0 0 0.108881160679352 0 0 0.254472044523618 7.42037103517168e-06 20 2071 True False 0 0 0 0 0 0 0 0.0478425985778926 0.00117921582340927 0.286554306624202 0 0 0.000476793790149404 0.997305036213576 0.99619762638504 0.99815593879969 37 3) Uncertain significance No change no 1 +Streptomycin rrs n.5_6delGTinsTGG rrs_n.5_6delGTinsTGG 1 non_coding_transcript_exon_variant 1471850 0 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1994 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1660 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 5 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.504A>G rrs_n.504A>G 1 non_coding_transcript_exon_variant 1472349 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1978 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1645 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 2 3) Uncertain significance No change no 1 +Streptomycin rrs n.513C>T rrs_n.513C>T 1 non_coding_transcript_exon_variant 1472358 1 3 3 0 20 1 10348 15607 0.00192901234567901 0.00117867659406302 0.00297763858885685 0.999935930292158 0.99964307871082 0.999998377896754 0.952380952380952 0.761840090063179 0.998795116551636 1 0.292401773821286 1 0.75 0.194120449683243 0.99369053679029 Inf 0.623111097946191 Inf 0.0633953720043728 108 2512 False False 30.1642829532276 4.82277637448433 1242.98463694859 0.000289827069848323 5.97732980577396e-05 0.000846761755708225 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 3 0 6 0 7730 11874 0.00077559462254395 0.000284681048736677 0.00168737281383633 1 0.999689379610589 1 1 0.540741873560099 1 1 0.292401773821286 1 1 0.292401773821286 1 Inf 0.634584400563999 Inf 0.0613350233619925 90 2071 False False 0 0 0 0 0 0 0 Inf 1.80798545886233 Inf 0.000387947756368809 8.00113005907662e-05 0.00113332526638003 1 0.999689379610589 1 7 3) Uncertain significance No change no 1 +Streptomycin rrs n.514A>C rrs_n.514A>C 1 non_coding_transcript_exon_variant 1472359 1 316 305 11 550 18 9818 15590 0.0530478395061728 0.048811467554335 0.0575373951900739 0.998846745258841 0.998177970363271 0.999316369446418 0.968309859154929 0.950377156346526 0.981112449627048 0.965189873417721 0.938569793242598 0.982497190462948 0.944272445820433 0.913354337131504 0.966641554427385 44.0281301505583 24.24367135661 89.367850594146 5.48179807131889e-108 5 2512 True False 48.519159819832 30.3780703137059 82.381998728145 0.0301294082781784 0.0268857499535832 0.0336469565816449 0.998846745258841 0.998177970363271 0.999316369446418 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 260 253 7 449 9 7287 11865 0.0580403309203722 0.0529326019137203 0.0634841083098951 0.999242041435068 0.998561648359028 0.999653356368186 0.980349344978166 0.963025733454749 0.990976057001506 0.973076923076923 0.945317344678215 0.989108469654676 0.965648854961832 0.935794579875151 0.984174376062321 58.8493207081103 28.1331897489344 148.337934473717 4.69527363051792e-94 5 2071 True False 0 0 0 0 0 0 0 81.2311879602945 42.415763390524 179.244360261161 0.0335543766578249 0.0296045769915245 0.0378698864606645 0.999242041435068 0.998561648359028 0.999653356368186 1131 Assoc w R Assoc w R 1) Assoc w R No change yes 1 +Streptomycin rrs n.514A>T rrs_n.514A>T 1 non_coding_transcript_exon_variant 1472359 1 13 8 5 14 6 10354 15602 0.0013503086419753 0.00073841672613154 0.00226455162408295 0.999615581752947 0.999163472525571 0.999858912630967 0.7 0.45721081772371 0.881068409594272 0.615384615384615 0.315777602914063 0.861420661109839 0.571428571428571 0.288609400038307 0.823388910017882 2.41097160517674 0.695179933225457 9.37063609591882 0.155008583048135 138 2512 False False 3.51600025754941 1.26867342065568 11.1638217372172 0.00077205172746574 0.000333374190510707 0.00152067986665076 0.999615581752947 0.999163472525571 0.999858912630967 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 4 3 10 4 7726 11870 0.00129265770423991 0.000620048157733657 0.00237595446225449 0.999663129526697 0.999137704464366 0.999908206750254 0.714285714285714 0.418964742816338 0.916110681692872 0.571428571428571 0.184051567640083 0.901011721557492 0.5 0.157012770487058 0.842987229512941 2.04849426179998 0.34644543204704 13.9891541143925 0.444978703447362 347 2071 False False 0 0 0 0 0 0 0 3.84092674087496 1.10725979503529 16.7765671286618 0.000517464424320828 0.000141009063241455 0.00132437962805983 0.999663129526697 0.999137704464366 0.999908206750254 10 3) Uncertain significance No change no 1 +Streptomycin rrs n.516C>T rrs_n.516C>T 1 non_coding_transcript_exon_variant 1472361 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1816 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1504 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.517C>T rrs_n.517C>T 1 non_coding_transcript_exon_variant 1472362 1 518 468 50 600 54 9768 15554 0.0578703703703703 0.0534523005879914 0.0625387470373703 0.996540235776524 0.995488139400087 0.997399882199051 0.91743119266055 0.893637473602634 0.937365093081938 0.903474903474903 0.874725766443852 0.927506808141283 0.896551724137931 0.867182700832793 0.921327017790694 14.9043243243243 11.1056270307417 20.392408649404 3.6319395270221e-132 4 2512 True False 17.6926926926926 13.3589171818563 23.8708590324505 0.0457209847596717 0.0417554034622686 0.0499475185727429 0.996540235776524 0.995488139400087 0.997399882199051 1) Assoc w R 1) Assoc w R ALL+WHO 1) Assoc w R 1 306 291 15 379 19 7357 11855 0.0489917269906928 0.044287820750362 0.0540390171502125 0.99839986525181 0.997502314270442 0.999036348042965 0.952261306532663 0.926451890395061 0.971016931885025 0.950980392156862 0.92043758739501 0.972307967919471 0.938709677419354 0.90594002086958 0.962699444549103 31.2609759412804 18.6181435225505 56.6283143591766 1.00204084137498e-98 4 2071 True False 0 0 0 0 0 0 0 32.1430002217723 20.2709363409694 54.003351221054 0.0380491631799163 0.0338729756305315 0.0425819376152367 0.99839986525181 0.997502314270442 0.999036348042965 331 Assoc w R Assoc w R 1) Assoc w R No change yes 1 +Streptomycin rrs n.51T>C rrs_n.51T>C 1 non_coding_transcript_exon_variant 1471896 0 0 0 0 6 8 10362 15600 0.000578703703703703 0.000212402724453782 0.00125916554902567 0.999487442337262 0.998990308225149 0.99977868883794 0.428571428571428 0.176611089982117 0.711390599961692 NA NA NA 0 0 0.369416647552819 NA NA NA NA 2008 2512 False False 1.12912565141864 0.322800697944735 3.71172362665047 0 0 0.000355937358633142 0.999487442337262 0.998990308225149 0.99977868883794 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 8 7732 11866 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.999326259053394 0.998672895689377 0.999709083033384 0.333333333333333 0.0992460911495833 0.651124493581186 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1670 2071 False False 0 0 0 0 0 0 0 0.767330574236937 0.169034015048489 2.86517783020669 0 0 0.000476978741026985 0.999326259053394 0.998672895689377 0.999709083033384 75 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.529T>C rrs_n.529T>C 1 non_coding_transcript_exon_variant 1472374 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2087 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.-52T>G rrs_n.-52T>G 1 upstream_gene_variant 1471794 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1749 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1446 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.533G>T rrs_n.533G>T 1 non_coding_transcript_exon_variant 1472378 0 0 0 0 7 16 10361 15592 0.000675154320987654 0.000271488767107418 0.00139057803317028 0.998974884674526 0.998335809333792 0.999413948080433 0.304347826086956 0.132102879698099 0.529191666008506 NA NA NA 0 0 0.205907214207822 NA NA NA NA 1949 2512 False False 0.658382395521667 0.228973022871038 1.69228665527628 0 0 0.000355971706089883 0.998974884674526 0.998335809333792 0.999413948080433 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 5 15 7731 11859 0.000646328852119958 0.0002098934625097 0.00150766595359595 0.998736735725113 0.997917292278642 0.999292793629768 0.25 0.0865714691014345 0.491045871707957 NA NA NA 0 0 0.218019360910534 NA NA NA NA 1624 2071 False False 0 0 0 0 0 0 0 0.51131807010736 0.145331267874464 1.4807912043683 0 0 0.000477040423209609 0.998736735725113 0.997917292278642 0.999292793629768 63 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.534T>C rrs_n.534T>C 1 non_coding_transcript_exon_variant 1472379 0 0 0 0 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1961 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 0 0 0.000355765720726338 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1631 2071 False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 0 0 0.000476793790149404 0.999831564763348 0.99939168785815 0.999979601060482 77 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.534T>G rrs_n.534T>G 1 non_coding_transcript_exon_variant 1472379 0 0 0 0 10 15 10358 15593 0.000964506172839506 0.000462612020337809 0.00177304351401163 0.999038954382368 0.998415396005541 0.999462013453075 0.4 0.211254806465142 0.61334650374316 NA NA NA 0 0 0.218019360910534 NA NA NA NA 1740 2512 False False 1.0036042994143 0.403019853923277 2.38905887332637 0 0 0.000356074788245403 0.999038954382368 0.998415396005541 0.999462013453075 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 7 14 7729 11860 0.000904860392967942 0.000363875741427306 0.00186346392020999 0.998820953343439 0.9980225505579 0.99935525904558 0.333333333333333 0.145876942343096 0.569675482904124 NA NA NA 0 0 0.231635761650116 NA NA NA NA 1438 2071 False False 0 0 0 0 0 0 0 0.767240263941001 0.261955539366344 2.03251552874274 0 0 0.000477163835447126 0.998820953343439 0.9980225505579 0.99935525904558 30 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.535G>C rrs_n.535G>C 1 non_coding_transcript_exon_variant 1472380 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2159 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1805 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 40 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.537G>A rrs_n.537G>A 1 non_coding_transcript_exon_variant 1472382 0 0 0 0 9 15 10359 15593 0.000868055555555555 0.000397004661559041 0.00164719739830421 0.999038954382368 0.998415396005541 0.999462013453075 0.375 0.187992928196002 0.594063615992055 NA NA NA 0 0 0.218019360910534 NA NA NA NA 2042 2512 False False 0.903156675354764 0.348346621795783 2.20381467996562 0 0 0.000356040420894094 0.999038954382368 0.998415396005541 0.999462013453075 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 6 14 7730 11860 0.00077559462254395 0.000284681048736677 0.00168737281383633 0.998820953343439 0.9980225505579 0.99935525904558 0.3 0.118931590405727 0.542789182276289 NA NA NA 0 0 0.231635761650116 NA NA NA NA 1701 2071 False False 0 0 0 0 0 0 0 0.657549436333394 0.207012751402268 1.82254803401651 0 0 0.000477102121347592 0.998820953343439 0.9980225505579 0.99935525904558 42 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.544G>A rrs_n.544G>A 1 non_coding_transcript_exon_variant 1472389 0 0 0 0 2 11 10366 15597 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999295233213736 0.998739328260189 0.999648132128855 0.153846153846153 0.0192066719825284 0.454471055676557 NA NA NA 0 0 0.284914152918154 NA NA NA NA 1817 2512 False False 0.273569185975128 0.0294615289970011 1.25390948755432 0 0 0.000355800035063835 0.999295233213736 0.998739328260189 0.999648132128855 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 10 7734 11864 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999157823816742 0.998451755191613 0.9995960722577 0.166666666666666 0.0208625254600923 0.484137748685967 NA NA NA 0 0 0.30849710781876 NA NA NA NA 1505 2071 False False 0 0 0 0 0 0 0 0.306801137832945 0.0326749863301206 1.44030192974163 0 0 0.000476855424503066 0.999157823816742 0.998451755191613 0.9995960722577 17 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.551A>T rrs_n.551A>T 1 non_coding_transcript_exon_variant 1472396 0 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1890 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1572 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 53 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.554A>T rrs_n.554A>T 1 non_coding_transcript_exon_variant 1472399 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.555C>T rrs_n.555C>T 1 non_coding_transcript_exon_variant 1472400 0 0 0 0 13 23 10355 15585 0.00125385802469135 0.000667790166179422 0.00214318097672708 0.998526396719631 0.997789687011067 0.999065639764335 0.361111111111111 0.208222947086592 0.537790999831836 NA NA NA 0 0 0.148185128915224 NA NA NA NA 2058 2512 False False 0.850691747318035 0.395641963829326 1.75213713073447 0 0 0.000356177930119202 0.998526396719631 0.997789687011067 0.999065639764335 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 10 22 7726 11852 0.00129265770423991 0.000620048157733657 0.00237595446225449 0.998147212396833 0.997196193207206 0.998838514973534 0.3125 0.1611847240882 0.500077581632169 NA NA NA 0 0 0.154372512815574 NA NA NA NA 1715 2071 False False 0 0 0 0 0 0 0 0.697291318570117 0.294609394112218 1.53555774284674 0 0 0.000477349073576999 0.998147212396833 0.997196193207206 0.998838514973534 135 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.556dupT rrs_n.556dupT 1 non_coding_transcript_exon_variant 1472400 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2102 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1754 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.556T>C rrs_n.556T>C 1 non_coding_transcript_exon_variant 1472401 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1741 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.55C>T rrs_n.55C>T 1 non_coding_transcript_exon_variant 1471900 0 0 0 0 6 8 10362 15600 0.000578703703703703 0.000212402724453782 0.00125916554902567 0.999487442337262 0.998990308225149 0.99977868883794 0.428571428571428 0.176611089982117 0.711390599961692 NA NA NA 0 0 0.369416647552819 NA NA NA NA 2160 2512 False False 1.12912565141864 0.322800697944735 3.71172362665047 0 0 0.000355937358633142 0.999487442337262 0.998990308225149 0.99977868883794 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 8 7732 11866 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.999326259053394 0.998672895689377 0.999709083033384 0.333333333333333 0.0992460911495833 0.651124493581186 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1806 2071 False False 0 0 0 0 0 0 0 0.767330574236937 0.169034015048489 2.86517783020669 0 0 0.000476978741026985 0.999326259053394 0.998672895689377 0.999709083033384 69 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.-55T>G rrs_n.-55T>G 1 upstream_gene_variant 1471791 0 0 0 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1983 2512 False False Inf 0.282736080598822 Inf 0 0 0.000355800035063835 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1650 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0 0 0.000476855424503066 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.560C>T rrs_n.560C>T 1 non_coding_transcript_exon_variant 1472405 0 0 0 0 3 1 10365 15607 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999935930292158 0.99964307871082 0.999998377896754 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 2088 2512 False False 4.51722141823444 0.362625225225282 236.854590713406 0 0 0.000355834356021348 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 1 7733 11873 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 0.999915782381674 0.999530859783396 0.999997867796783 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 1742 2071 False False 0 0 0 0 0 0 0 4.60610371136686 0.369734697559289 241.512824517625 0 0 0.000476917074793532 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.567A>C rrs_n.567A>C 1 non_coding_transcript_exon_variant 1472412 0 0 0 0 2 9 10366 15599 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.99942337262942 0.998905665124108 0.999736296428239 0.181818181818181 0.0228311982999596 0.517755852360172 NA NA NA 0 0 0.336267116879942 NA NA NA NA 2059 2512 False False 0.334405213625742 0.0351449615056338 1.61615001031672 0 0 0.000355800035063835 0.99942337262942 0.998905665124108 0.999736296428239 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 8 7734 11866 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999326259053394 0.998672895689377 0.999709083033384 0.2 0.0252107263268333 0.556095462307641 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1716 2071 False False 0 0 0 0 0 0 0 0.383566071890354 0.0396726760071963 1.92279965315068 0 0 0.000476855424503066 0.999326259053394 0.998672895689377 0.999709083033384 5 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.567A>G rrs_n.567A>G 1 non_coding_transcript_exon_variant 1472412 1 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2161 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1807 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 8 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.569C>T rrs_n.569C>T 1 non_coding_transcript_exon_variant 1472414 1 6 0 6 1 6 10367 15602 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999615581752947 0.999163472525571 0.999858912630967 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.27850451570591 0.0875884272338781 127.5 2512 False False 0.250827947654416 0.00545680578940276 2.0680301831463 0 0 0.000355765720726338 0.999615581752947 0.999163472525571 0.999858912630967 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17379939830658 0.52225229054203 453 2071 False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 0 0 0.000476793790149404 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.-56T>C rrs_n.-56T>C 1 upstream_gene_variant 1471790 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1895 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1576 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.570T>G rrs_n.570T>G 1 non_coding_transcript_exon_variant 1472415 0 0 0 0 2 10 10366 15598 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999359302921578 0.998822051949738 0.999692719453314 0.166666666666666 0.0208625254600923 0.484137748685967 NA NA NA 0 0 0.30849710781876 NA NA NA NA 1922 2512 False False 0.300945398417904 0.0320539241983817 1.41265925137959 0 0 0.000355800035063835 0.999359302921578 0.998822051949738 0.999692719453314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 9 7734 11865 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999242041435068 0.998561648359028 0.999653356368186 0.181818181818181 0.0228311982999596 0.517755852360172 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1598 2071 False False 0 0 0 0 0 0 0 0.340918886302904 0.035825231429456 1.64780389313877 0 0 0.000476855424503066 0.999242041435068 0.998561648359028 0.999653356368186 5 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.571C>T rrs_n.571C>T 1 non_coding_transcript_exon_variant 1472416 0 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1832 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1519 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 24 3) Uncertain significance No change no 1 +Streptomycin rrs n.573T>C rrs_n.573T>C 1 non_coding_transcript_exon_variant 1472418 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1859 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1544 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.577T>C rrs_n.577T>C 1 non_coding_transcript_exon_variant 1472422 0 0 0 0 4 11 10364 15597 0.000385802469135802 0.000105127872737001 0.000987510251175401 0.999295233213736 0.998739328260189 0.999648132128855 0.266666666666666 0.0778715462910436 0.551003241036971 NA NA NA 0 0 0.284914152918154 NA NA NA NA 2009 2512 False False 0.547243956352408 0.127053504005292 1.84748938892664 0 0 0.000355868683600791 0.999295233213736 0.998739328260189 0.999648132128855 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 10 7732 11864 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.999157823816742 0.998451755191613 0.9995960722577 0.285714285714285 0.0838893183071275 0.581035257183661 NA NA NA 0 0 0.30849710781876 NA NA NA NA 1671 2071 False False 0 0 0 0 0 0 0 0.613760993274702 0.14045294063066 2.12901862852369 0 0 0.000476978741026985 0.999157823816742 0.998451755191613 0.9995960722577 33 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.580T>C rrs_n.580T>C 1 non_coding_transcript_exon_variant 1472425 0 0 0 0 3 2 10365 15606 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999871860584315 0.999537193839207 0.999984481345552 0.6 0.146632799634673 0.947255049473683 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2135 2512 False False 2.25846599131693 0.258657968313028 27.0476864113414 0 0 0.000355834356021348 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1784 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0 0 0.000476855424503066 1 0.999689379610589 1 3 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.581T>G rrs_n.581T>G 1 non_coding_transcript_exon_variant 1472426 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2073 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1729 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.590T>C rrs_n.590T>C 1 non_coding_transcript_exon_variant 1472435 0 0 0 0 2 1 10366 15607 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999935930292158 0.99964307871082 0.999998377896754 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 1726 2512 False False 3.01119043025274 0.156729426968348 177.474331043773 0 0 0.000355800035063835 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 1 7734 11873 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999915782381674 0.999530859783396 0.999997867796783 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 1427 2071 False False 0 0 0 0 0 0 0 3.07033876389966 0.159799628612092 180.959738606129 0 0 0.000476855424503066 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.592T>A rrs_n.592T>A 1 non_coding_transcript_exon_variant 1472437 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1950 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1625 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.593T>C rrs_n.593T>C 1 non_coding_transcript_exon_variant 1472438 0 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1742 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1439 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.594C>T rrs_n.594C>T 1 non_coding_transcript_exon_variant 1472439 0 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1727 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1428 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.5G>T rrs_n.5G>T 1 non_coding_transcript_exon_variant 1471850 1 3 0 3 1 6 10367 15602 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999615581752947 0.999163472525571 0.999858912630967 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.707598226178713 0 0 0.4592581264399 0 0 3.64264564277489 0.280478029128711 225 2512 False False 0.250827947654416 0.00545680578940276 2.0680301831463 0 0 0.000355765720726338 0.999615581752947 0.999163472525571 0.999858912630967 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1607 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 15 3) Uncertain significance No change no 1 +Streptomycin rrs n.600A>G rrs_n.600A>G 1 non_coding_transcript_exon_variant 1472445 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2010 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1672 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.602C>T rrs_n.602C>T 1 non_coding_transcript_exon_variant 1472447 0 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1979 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1646 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.603T>C rrs_n.603T>C 1 non_coding_transcript_exon_variant 1472448 1 1 0 1 2 2 10366 15606 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999871860584315 0.999537193839207 0.999984481345552 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 58.6653062545381 1 973.5 2512 False False 1.50549874590005 0.10909391082996 20.7696540777406 0 0 0.000355800035063835 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 1 7734 11873 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999915782381674 0.999530859783396 0.999997867796783 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 1520 2071 False False 0 0 0 0 0 0 0 3.07033876389966 0.159799628612092 180.959738606129 0 0 0.000476855424503066 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance No change no 1 +Streptomycin rrs n.605A>G rrs_n.605A>G 1 non_coding_transcript_exon_variant 1472450 0 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1771 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1464 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.606C>G rrs_n.606C>G 1 non_coding_transcript_exon_variant 1472451 0 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1692 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1399 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.-60T>C rrs_n.-60T>C 1 upstream_gene_variant 1471786 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1910 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1589 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.616G>C rrs_n.616G>C 1 non_coding_transcript_exon_variant 1472461 0 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1891 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1573 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.617T>C rrs_n.617T>C 1 non_coding_transcript_exon_variant 1472462 0 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1818 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1506 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.619A>G rrs_n.619A>G 1 non_coding_transcript_exon_variant 1472464 0 0 0 0 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2074 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 0 0 0.000355765720726338 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1730 2071 False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 0 0 0.000476793790149404 0.999831564763348 0.99939168785815 0.999979601060482 4 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.626G>A rrs_n.626G>A 1 non_coding_transcript_exon_variant 1472471 0 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1711 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1415 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 3 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.628G>T rrs_n.628G>T 1 non_coding_transcript_exon_variant 1472473 0 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2136 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1785 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.629C>G rrs_n.629C>G 1 non_coding_transcript_exon_variant 1472474 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2043 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1702 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.637G>A rrs_n.637G>A 1 non_coding_transcript_exon_variant 1472482 1 0 0 0 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1757 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1452 2071 False False 0 0 0 0 0 0 0 0 0 3.71438150990605 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 2 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.639A>C rrs_n.639A>C 1 non_coding_transcript_exon_variant 1472484 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1902 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1581 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.639A>T rrs_n.639A>T 1 non_coding_transcript_exon_variant 1472484 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1743 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1440 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.-63C>G rrs_n.-63C>G 1 upstream_gene_variant 1471783 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.641A>G rrs_n.641A>G 1 non_coding_transcript_exon_variant 1472486 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1819 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1507 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 3 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.643dupT rrs_n.643dupT 1 non_coding_transcript_exon_variant 1472487 1 8 0 8 0 8 10368 15600 0 0 0.000355731413006942 0.999487442337262 0.998990308225149 0.99977868883794 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.881730950187969 0.0253713752416919 88 2512 False False 0 0 0.881730950187969 0 0 0.000355731413006942 0.999487442337262 0.998990308225149 0.99977868883794 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 0 8 7736 11866 0 0 0.000476732171726368 0.999326259053394 0.998672895689377 0.999709083033384 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.369416647552819 0 0 0.898935416250629 0.0258315649725931 69 2071 False False 0 0 0 0 0 0 0 0 0 0.898935416250629 0 0 0.000476732171726368 0.999326259053394 0.998672895689377 0.999709083033384 13 3) Uncertain significance No change no 1 +Streptomycin rrs n.644A>G rrs_n.644A>G 1 non_coding_transcript_exon_variant 1472489 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.644A>T rrs_n.644A>T 1 non_coding_transcript_exon_variant 1472489 0 0 0 0 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1712 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 0 0 0.000355765720726338 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1416 2071 False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 0 0 0.000476793790149404 0.999831564763348 0.99939168785815 0.999979601060482 5 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.645dupG rrs_n.645dupG 1 non_coding_transcript_exon_variant 1472489 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.646A>G rrs_n.646A>G 1 non_coding_transcript_exon_variant 1472491 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.649A>G rrs_n.649A>G 1 non_coding_transcript_exon_variant 1472494 1 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2162 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1808 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 17 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.649A>T rrs_n.649A>T 1 non_coding_transcript_exon_variant 1472494 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2075 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1731 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 3 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.650C>T rrs_n.650C>T 1 non_coding_transcript_exon_variant 1472495 0 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1784 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1475 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 3 3) Uncertain significance No change no 1 +Streptomycin rrs n.651T>G rrs_n.651T>G 1 non_coding_transcript_exon_variant 1472496 0 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1872 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1554 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 6 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.652G>T rrs_n.652G>T 1 non_coding_transcript_exon_variant 1472497 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2120 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1771 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.653C>T rrs_n.653C>T 1 non_coding_transcript_exon_variant 1472498 0 0 0 0 1 3 10367 15605 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999807790876473 0.99943838714673 0.999960360103688 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1744 2512 False False 0.501752355229735 0.00956153582768186 6.25014259670444 0 0 0.000355765720726338 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 3 7735 11871 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999747347145022 0.999261820436506 0.999947893876346 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1441 2071 False False 0 0 0 0 0 0 0 0.511570782159017 0.0097482170621519 6.37282132403124 0 0 0.000476793790149404 0.999747347145022 0.999261820436506 0.999947893876346 20 3) Uncertain significance No change no 1 +Streptomycin rrs n.-65G>A rrs_n.-65G>A 1 upstream_gene_variant 1471781 1 5 0 5 3 5 10365 15603 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999679651460789 0.999252573060182 0.999895975781355 0.375 0.0852334141372535 0.755136783633448 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.6431366527397 0.1646513336333 192 2512 False False 0.903212735166425 0.140213309764784 4.64350502715881 0 0 0.000355834356021348 0.999679651460789 0.999252573060182 0.999895975781355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 2 4 7734 11870 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999663129526697 0.999137704464366 0.999908206750254 0.333333333333333 0.0432718682927417 0.777221904496487 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.32573181154423 0.158644779998294 151 2071 False False 0 0 0 0 0 0 0 0.767390742177398 0.0693820092373707 5.35625075908251 0 0 0.000476855424503066 0.999663129526697 0.999137704464366 0.999908206750254 5 3) Uncertain significance No change no 1 +Streptomycin rrs n.-65G>T rrs_n.-65G>T 1 upstream_gene_variant 1471781 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.660G>T rrs_n.660G>T 1 non_coding_transcript_exon_variant 1472505 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance No change no 1 +Streptomycin rrs n.662C>G rrs_n.662C>G 1 non_coding_transcript_exon_variant 1472507 0 0 0 0 3 4 10365 15604 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999743721168631 0.999343955596995 0.999930168370675 0.428571428571428 0.0989882784425078 0.815948432359917 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1860 2512 False False 1.12908827785817 0.165354282141397 6.67552078522212 0 0 0.000355834356021348 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 4 7734 11870 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999663129526697 0.999137704464366 0.999908206750254 0.333333333333333 0.0432718682927417 0.777221904496487 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1545 2071 False False 0 0 0 0 0 0 0 0.767390742177398 0.0693820092373707 5.35625075908251 0 0 0.000476855424503066 0.999663129526697 0.999137704464366 0.999908206750254 41 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.663T>C rrs_n.663T>C 1 non_coding_transcript_exon_variant 1472508 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1995 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1661 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance No change no 1 +Streptomycin rrs n.66C>A rrs_n.66C>A 1 non_coding_transcript_exon_variant 1471911 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2011 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1673 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 28 3) Uncertain significance No change no 1 +Streptomycin rrs n.672T>A rrs_n.672T>A 1 non_coding_transcript_exon_variant 1472517 0 0 0 0 6 12 10362 15596 0.000578703703703703 0.000212402724453782 0.00125916554902567 0.999231163505894 0.998657382918185 0.999602669866138 0.333333333333333 0.133427402506123 0.590074761827925 NA NA NA 0 0 0.264648469397051 NA NA NA NA 1873 2512 False False 0.75255742134723 0.231661879081194 2.1674066734118 0 0 0.000355937358633142 0.999231163505894 0.998657382918185 0.999602669866138 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 5 11 7731 11863 0.000646328852119958 0.0002098934625097 0.00150766595359595 0.999073606198416 0.998343031567643 0.999537459717592 0.3125 0.110169954717117 0.586620636451358 NA NA NA 0 0 0.284914152918154 NA NA NA NA 1555 2071 False False 0 0 0 0 0 0 0 0.697487094460319 0.189914965598158 2.17861329565642 0 0 0.000477040423209609 0.999073606198416 0.998343031567643 0.999537459717592 55 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.672T>G rrs_n.672T>G 1 non_coding_transcript_exon_variant 1472517 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.673G>A rrs_n.673G>A 1 non_coding_transcript_exon_variant 1472518 0 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1758 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1453 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 3 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.673G>C rrs_n.673G>C 1 non_coding_transcript_exon_variant 1472518 0 0 0 0 3 3 10365 15605 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999807790876473 0.99943838714673 0.999960360103688 0.5 0.118117248757025 0.881882751242974 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2121 2512 False False 1.50554751567776 0.201606412693291 11.2464963121379 0 0 0.000355834356021348 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 3 7734 11871 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999747347145022 0.999261820436506 0.999947893876346 0.4 0.0527449505263169 0.853367200365326 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1772 2071 False False 0 0 0 0 0 0 0 1.02327385570209 0.0854221600622099 8.93608975066686 0 0 0.000476855424503066 0.999747347145022 0.999261820436506 0.999947893876346 2 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.673G>T rrs_n.673G>T 1 non_coding_transcript_exon_variant 1472518 0 0 0 0 2 8 10366 15600 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999487442337262 0.998990308225149 0.99977868883794 0.2 0.0252107263268333 0.556095462307641 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1785 2512 False False 0.376229982635539 0.0389158944356182 1.88584091729022 0 0 0.000355800035063835 0.999487442337262 0.998990308225149 0.99977868883794 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 7 7734 11867 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999410476671719 0.998785736251934 0.999762949244471 0.222222222222222 0.0281449734778982 0.600093573716312 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1476 2071 False False 0 0 0 0 0 0 0 0.438398167645646 0.044427948910893 2.30343996509364 0 0 0.000476855424503066 0.999410476671719 0.998785736251934 0.999762949244471 52 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.-67T>C rrs_n.-67T>C 1 upstream_gene_variant 1471779 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.685G>A rrs_n.685G>A 1 non_coding_transcript_exon_variant 1472530 0 0 0 0 13 19 10355 15589 0.00125385802469135 0.000667790166179422 0.00214318097672708 0.998782675550999 0.998099646955 0.999266937052498 0.40625 0.236984100551743 0.593550753423523 NA NA NA 0 0 0.176466911806965 NA NA NA NA 2103 2512 False False 1.03004904826043 0.467357194223492 2.19957816287044 0 0 0.000356177930119202 0.998782675550999 0.998099646955 0.999266937052498 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 11 17 7725 11857 0.0014219234746639 0.000710026047388019 0.00254278626393864 0.998568300488462 0.997708696799157 0.999165768038889 0.392857142857142 0.215042829160961 0.594231793512436 NA NA NA 0 0 0.195064322969093 NA NA NA NA 1755 2071 False False 0 0 0 0 0 0 0 0.993162002665143 0.420249503783086 2.24915254660728 0 0 0.000477410851584718 0.998568300488462 0.997708696799157 0.999165768038889 136 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.-68G>C rrs_n.-68G>C 1 upstream_gene_variant 1471778 1 1 0 1 2 2 10366 15606 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999871860584315 0.999537193839207 0.999984481345552 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 58.6653062545381 1 973.5 2512 False False 1.50549874590005 0.10909391082996 20.7696540777406 0 0 0.000355800035063835 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.692C>T rrs_n.692C>T 1 non_coding_transcript_exon_variant 1472537 0 0 0 0 7 8 10361 15600 0.000675154320987654 0.000271488767107418 0.00139057803317028 0.999487442337262 0.998990308225149 0.99977868883794 0.466666666666666 0.212666729519307 0.734138652722603 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1759 2512 False False 1.31744040150564 0.406565769402037 4.1590217879041 0 0 0.000355971706089883 0.999487442337262 0.998990308225149 0.99977868883794 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 5 7 7731 11867 0.000646328852119958 0.0002098934625097 0.00150766595359595 0.999410476671719 0.998785736251934 0.999762949244471 0.416666666666666 0.15165222980843 0.723330314317894 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1454 2071 False False 0 0 0 0 0 0 0 1.0964207180738 0.274287483368725 4.01478723207519 0 0 0.000477040423209609 0.999410476671719 0.998785736251934 0.999762949244471 133 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.696T>G rrs_n.696T>G 1 non_coding_transcript_exon_variant 1472541 0 0 0 0 7 13 10361 15595 0.000675154320987654 0.000271488767107418 0.00139057803317028 0.999167093798052 0.998576126182689 0.999556440358575 0.35 0.153909204784541 0.592188534532828 NA NA NA 0 0 0.24705263800047 NA NA NA NA 1962 2512 False False 0.810472704594893 0.273710443065826 2.18655461968969 0 0 0.000355971706089883 0.999167093798052 0.998576126182689 0.999556440358575 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 5 12 7731 11862 0.000646328852119958 0.0002098934625097 0.00150766595359595 0.998989388580091 0.998235331388827 0.999477696754876 0.294117647058823 0.103135514370319 0.559582718754337 NA NA NA 0 0 0.264648469397051 NA NA NA NA 1632 2071 False False 0 0 0 0 0 0 0 0.639309274350019 0.176392788072126 1.9504697349776 0 0 0.000477040423209609 0.998989388580091 0.998235331388827 0.999477696754876 17 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.699C>A rrs_n.699C>A 1 non_coding_transcript_exon_variant 1472544 0 0 0 0 2 11 10366 15597 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999295233213736 0.998739328260189 0.999648132128855 0.153846153846153 0.0192066719825284 0.454471055676557 NA NA NA 0 0 0.284914152918154 NA NA NA NA 2089 2512 False False 0.273569185975128 0.0294615289970011 1.25390948755432 0 0 0.000355800035063835 0.999295233213736 0.998739328260189 0.999648132128855 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 9 7734 11865 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999242041435068 0.998561648359028 0.999653356368186 0.181818181818181 0.0228311982999596 0.517755852360172 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1743 2071 False False 0 0 0 0 0 0 0 0.340918886302904 0.035825231429456 1.64780389313877 0 0 0.000476855424503066 0.999242041435068 0.998561648359028 0.999653356368186 143 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.699C>G rrs_n.699C>G 1 non_coding_transcript_exon_variant 1472544 0 0 0 0 6 3 10362 15605 0.000578703703703703 0.000212402724453782 0.00125916554902567 0.999807790876473 0.99943838714673 0.999960360103688 0.666666666666666 0.29929505620854 0.925145368580308 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1772 2512 False False 3.01196680177571 0.64305389468782 18.6152161733465 0 0 0.000355937358633142 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 3 7732 11871 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.999747347145022 0.999261820436506 0.999947893876346 0.571428571428571 0.184051567640083 0.901011721557492 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1465 2071 False False 0 0 0 0 0 0 0 2.04707708225556 0.346205885559351 13.9794751519065 0 0 0.000476978741026985 0.999747347145022 0.999261820436506 0.999947893876346 8 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.699C>T rrs_n.699C>T 1 non_coding_transcript_exon_variant 1472544 1 1 0 1 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 58.6540000158548 1 973.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1688 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance No change no 1 +Streptomycin rrs n.69A>G rrs_n.69A>G 1 non_coding_transcript_exon_variant 1471914 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1903 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1582 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.-69C>G rrs_n.-69C>G 1 upstream_gene_variant 1471777 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2107 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1759 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance No change no 1 +Streptomycin rrs n.-69C>T rrs_n.-69C>T 1 upstream_gene_variant 1471777 1 13 0 13 0 19 10368 15589 0 0 0.000355731413006942 0.998782675550999 0.998099646955 0.999266937052498 0 0 0.176466911806965 0 0 0.24705263800047 0 0 0.176466911806965 0 0 0.493495515648658 0.00261278752159703 51 2512 False False 0 0 0.322312801470408 0 0 0.000355731413006942 0.998782675550999 0.998099646955 0.999266937052498 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 13 0 13 0 19 7736 11855 0 0 0.000476732171726368 0.99839986525181 0.997502314270442 0.999036348042965 0 0 0.176466911806965 0 0 0.24705263800047 0 0 0.176466911806965 0 0 0.503018643050249 0.00261004284257853 43 2071 False False 0 0 0 0 0 0 0 0 0 0.328511972437248 0 0 0.000476732171726368 0.99839986525181 0.997502314270442 0.999036348042965 2 3) Uncertain significance No change no 1 +Streptomycin rrs n.700A>C rrs_n.700A>C 1 non_coding_transcript_exon_variant 1472545 1 0 0 0 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1833 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1521 2071 False False 0 0 0 0 0 0 0 0 0 3.71438150990605 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.700A>T rrs_n.700A>T 1 non_coding_transcript_exon_variant 1472545 0 0 0 0 8 15 10360 15593 0.000771604938271604 0.00033318123262376 0.00151980017311994 0.999038954382368 0.998415396005541 0.999462013453075 0.347826086956521 0.163763598374949 0.572656036963505 NA NA NA 0 0 0.218019360910534 NA NA NA NA 1773 2512 False False 0.802728442728442 0.294673444738778 2.01786452943857 0 0 0.000356006060176228 0.999038954382368 0.998415396005541 0.999462013453075 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 6 13 7730 11861 0.00077559462254395 0.000284681048736677 0.00168737281383633 0.998905170961765 0.998128536682641 0.999416924941029 0.31578947368421 0.125760635872983 0.56550156884615 NA NA NA 0 0 0.24705263800047 NA NA NA NA 1466 2071 False False 0 0 0 0 0 0 0 0.70818986963877 0.220630384115051 1.99802801684607 0 0 0.000477102121347592 0.998905170961765 0.998128536682641 0.999416924941029 154 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.703A>G rrs_n.703A>G 1 non_coding_transcript_exon_variant 1472548 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1951 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1626 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.704G>A rrs_n.704G>A 1 non_coding_transcript_exon_variant 1472549 0 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1693 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 0 1 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 59.8138891519084 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 14 3) Uncertain significance No change no 1 +Streptomycin rrs n.708C>T rrs_n.708C>T 1 non_coding_transcript_exon_variant 1472553 1 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1963 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1633 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 5 3) Uncertain significance No change no 1 +Streptomycin rrs n.-70G>A rrs_n.-70G>A 1 upstream_gene_variant 1471776 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2001 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1666 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.-70G>C rrs_n.-70G>C 1 upstream_gene_variant 1471776 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance No change no 1 +Streptomycin rrs n.710C>T rrs_n.710C>T 1 non_coding_transcript_exon_variant 1472555 1 0 0 0 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1932 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1608 2071 False False 0 0 0 0 0 0 0 0 0 3.71438150990605 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.712G>A rrs_n.712G>A 1 non_coding_transcript_exon_variant 1472557 0 0 0 0 13 20 10355 15588 0.00125385802469135 0.000667790166179422 0.00214318097672708 0.998718605843157 0.998021680992693 0.99921712098903 0.393939393939393 0.2290662383642 0.578606278611749 NA NA NA 0 0 0.168433470983085 NA NA NA NA 1861 2512 False False 0.978483824239498 0.447095993020702 2.06808718949567 0 0 0.000356177930119202 0.998718605843157 0.998021680992693 0.99921712098903 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 9 18 7727 11856 0.00116339193381592 0.000532110502771461 0.00220732634615895 0.998484082870136 0.997605251464505 0.999101331744648 0.333333333333333 0.165188179687315 0.539607286092257 NA NA NA 0 0 0.185301968137852 NA NA NA NA 1546 2071 False False 0 0 0 0 0 0 0 0.767180018118286 0.30345172182893 1.79948466955944 0 0 0.00047728731155563 0.998484082870136 0.997605251464505 0.999101331744648 31 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.713G>A rrs_n.713G>A 1 non_coding_transcript_exon_variant 1472558 0 0 0 0 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1996 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 0 0 0.000355765720726338 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1662 2071 False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 0 0 0.000476793790149404 0.999831564763348 0.99939168785815 0.999979601060482 17 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.717C>T rrs_n.717C>T 1 non_coding_transcript_exon_variant 1472562 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.-71G>A rrs_n.-71G>A 1 upstream_gene_variant 1471775 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.721G>A rrs_n.721G>A 1 non_coding_transcript_exon_variant 1472566 1 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1834 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1522 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 165 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.721G>C rrs_n.721G>C 1 non_coding_transcript_exon_variant 1472566 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1923 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1599 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.724G>A rrs_n.724G>A 1 non_coding_transcript_exon_variant 1472569 0 0 0 0 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2137 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 0 0 0.000355765720726338 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1786 2071 False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 0 0 0.000476793790149404 0.999831564763348 0.99939168785815 0.999979601060482 18 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.725G>A rrs_n.725G>A 1 non_coding_transcript_exon_variant 1472570 0 0 0 0 9 17 10359 15591 0.000868055555555555 0.000397004661559041 0.00164719739830421 0.998910814966683 0.998256680139026 0.999365385605091 0.346153846153846 0.172144138005666 0.55667192604239 NA NA NA 0 0 0.195064322969093 NA NA NA NA 1760 2512 False False 0.796800735932948 0.312845716825071 1.89075959059708 0 0 0.000356040420894094 0.998910814966683 0.998256680139026 0.999365385605091 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 7 15 7729 11859 0.000904860392967942 0.000363875741427306 0.00186346392020999 0.998736735725113 0.997917292278642 0.999292793629768 0.318181818181818 0.138646521553797 0.54872442757377 NA NA NA 0 0 0.218019360910534 NA NA NA NA 1455 2071 False False 0 0 0 0 0 0 0 0.716030534351145 0.246859413520769 1.86675630284717 0 0 0.000477163835447126 0.998736735725113 0.997917292278642 0.999292793629768 14 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.726G>A rrs_n.726G>A 1 non_coding_transcript_exon_variant 1472571 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2012 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1674 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 4 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.726G>C rrs_n.726G>C 1 non_coding_transcript_exon_variant 1472571 0 0 0 0 11 21 10357 15587 0.00106095679012345 0.000529741017552837 0.00189754996565939 0.998654536135315 0.997944046996364 0.999166949785744 0.34375 0.185719091716566 0.531931036280268 NA NA NA 0 0 0.161097615219079 NA NA NA NA 2013 2512 False False 0.788318919341416 0.343128178646541 1.71118651415261 0 0 0.000356109162232076 0.998654536135315 0.997944046996364 0.999166949785744 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 9 18 7727 11856 0.00116339193381592 0.000532110502771461 0.00220732634615895 0.998484082870136 0.997605251464505 0.999101331744648 0.333333333333333 0.165188179687315 0.539607286092257 NA NA NA 0 0 0.185301968137852 NA NA NA NA 1675 2071 False False 0 0 0 0 0 0 0 0.767180018118286 0.30345172182893 1.79948466955944 0 0 0.00047728731155563 0.998484082870136 0.997605251464505 0.999101331744648 212 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.727T>C rrs_n.727T>C 1 non_coding_transcript_exon_variant 1472572 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1952 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.728C>T rrs_n.728C>T 1 non_coding_transcript_exon_variant 1472573 0 0 0 0 4 10 10364 15598 0.000385802469135802 0.000105127872737001 0.000987510251175401 0.999359302921578 0.998822051949738 0.999692719453314 0.285714285714285 0.0838893183071275 0.581035257183661 NA NA NA 0 0 0.30849710781876 NA NA NA NA 1980 2512 False False 0.602006947124662 0.137811447809861 2.08794685943142 0 0 0.000355868683600791 0.999359302921578 0.998822051949738 0.999692719453314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 9 7732 11865 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.999242041435068 0.998561648359028 0.999653356368186 0.307692307692307 0.0909203945720966 0.614261661750705 NA NA NA 0 0 0.336267116879942 NA NA NA NA 1647 2071 False False 0 0 0 0 0 0 0 0.682014140369029 0.153421017946502 2.44469827824845 0 0 0.000476978741026985 0.999242041435068 0.998561648359028 0.999653356368186 18 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.730C>T rrs_n.730C>T 1 non_coding_transcript_exon_variant 1472575 0 0 0 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1862 2512 False False Inf 0.282736080598822 Inf 0 0 0.000355800035063835 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1547 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0 0 0.000476855424503066 1 0.999689379610589 1 2 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.734G>A rrs_n.734G>A 1 non_coding_transcript_exon_variant 1472579 0 0 0 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1820 2512 False False Inf 0.282736080598822 Inf 0 0 0.000355800035063835 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1508 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0 0 0.000476855424503066 1 0.999689379610589 1 4 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.734G>C rrs_n.734G>C 1 non_coding_transcript_exon_variant 1472579 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1849 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 97 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.734G>T rrs_n.734G>T 1 non_coding_transcript_exon_variant 1472579 0 0 0 0 7 20 10361 15588 0.000675154320987654 0.000271488767107418 0.00139057803317028 0.998718605843157 0.998021680992693 0.99921712098903 0.259259259259259 0.111144562845442 0.462848742276171 NA NA NA 0 0 0.168433470983085 NA NA NA NA 1933 2512 False False 0.526570794324872 0.18805545630655 1.29695285697827 0 0 0.000355971706089883 0.998718605843157 0.998021680992693 0.99921712098903 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 18 7732 11856 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.998484082870136 0.997605251464505 0.999101331744648 0.181818181818181 0.0518672993124368 0.402845783077871 NA NA NA 0 0 0.185301968137852 NA NA NA NA 1609 2071 False False 0 0 0 0 0 0 0 0.340748404897396 0.0838833390869796 1.0350036302414 0 0 0.000476978741026985 0.998484082870136 0.997605251464505 0.999101331744648 132 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.735C>A rrs_n.735C>A 1 non_coding_transcript_exon_variant 1472580 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2076 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1732 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.735C>G rrs_n.735C>G 1 non_coding_transcript_exon_variant 1472580 1 1 0 1 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 58.6540000158548 1 973.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1703 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 3 3) Uncertain significance No change no 1 +Streptomycin rrs n.735C>T rrs_n.735C>T 1 non_coding_transcript_exon_variant 1472580 1 1 0 1 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 58.6540000158548 1 973.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 96 3) Uncertain significance No change no 1 +Streptomycin rrs n.736A>C rrs_n.736A>C 1 non_coding_transcript_exon_variant 1472581 0 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2090 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1744 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 23 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.736A>T rrs_n.736A>T 1 non_coding_transcript_exon_variant 1472581 0 0 0 0 13 21 10355 15587 0.00125385802469135 0.000667790166179422 0.00214318097672708 0.998654536135315 0.997944046996364 0.999166949785744 0.38235294117647 0.221665430425496 0.56436028822861 NA NA NA 0 0 0.161097615219079 NA NA NA NA 2146 2512 False False 0.931829573934837 0.428488647369321 1.95103537637321 0 0 0.000356177930119202 0.998654536135315 0.997944046996364 0.999166949785744 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 9 18 7727 11856 0.00116339193381592 0.000532110502771461 0.00220732634615895 0.998484082870136 0.997605251464505 0.999101331744648 0.333333333333333 0.165188179687315 0.539607286092257 NA NA NA 0 0 0.185301968137852 NA NA NA NA 1793 2071 False False 0 0 0 0 0 0 0 0.767180018118286 0.30345172182893 1.79948466955944 0 0 0.00047728731155563 0.998484082870136 0.997605251464505 0.999101331744648 200 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.737G>A rrs_n.737G>A 1 non_coding_transcript_exon_variant 1472582 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1774 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1467 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 3 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.738T>A rrs_n.738T>A 1 non_coding_transcript_exon_variant 1472583 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1835 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1523 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 4 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.739A>T rrs_n.739A>T 1 non_coding_transcript_exon_variant 1472584 0 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1997 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1663 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 24 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.73A>T rrs_n.73A>T 1 non_coding_transcript_exon_variant 1471918 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1800 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1489 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.746G>A rrs_n.746G>A 1 non_coding_transcript_exon_variant 1472591 1 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1904 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1583 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 2 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.749G>A rrs_n.749G>A 1 non_coding_transcript_exon_variant 1472594 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.-74G>T rrs_n.-74G>T 1 upstream_gene_variant 1471772 1 2 0 2 2 5 10366 15603 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999679651460789 0.999252573060182 0.999895975781355 0.285714285714285 0.0366925661760855 0.709579136262657 0 0 0.841886116991581 0 0 0.521823750104981 0 0 8.01565320145906 0.520328018483695 538 2512 False False 0.602083735288443 0.0572994001432256 3.67859568857157 0 0 0.000355800035063835 0.999679651460789 0.999252573060182 0.999895975781355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 2 5 7734 11869 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999578911908371 0.999017596768841 0.999863260157969 0.285714285714285 0.0366925661760855 0.709579136262657 0 0 0.841886116991581 0 0 0.521823750104981 0 0 8.17279082464322 0.522239843936726 446 2071 False False 0 0 0 0 0 0 0 0.61386087406258 0.0584192274045222 3.75047184857656 0 0 0.000476855424503066 0.999578911908371 0.999017596768841 0.999863260157969 2 3) Uncertain significance No change no 1 +Streptomycin rrs n.751G>T rrs_n.751G>T 1 non_coding_transcript_exon_variant 1472596 0 0 0 0 3 12 10365 15596 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999231163505894 0.998657382918185 0.999602669866138 0.2 0.0433120051058366 0.480891133806853 NA NA NA 0 0 0.264648469397051 NA NA NA NA 1905 2512 False False 0.376169802219006 0.0681041402083858 1.39445373583362 0 0 0.000355834356021348 0.999231163505894 0.998657382918185 0.999602669866138 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 11 7734 11863 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999073606198416 0.998343031567643 0.999537459717592 0.153846153846153 0.0192066719825284 0.454471055676557 NA NA NA 0 0 0.284914152918154 NA NA NA NA 1584 2071 False False 0 0 0 0 0 0 0 0.278886616357524 0.0300333523224716 1.27842407058003 0 0 0.000476855424503066 0.999073606198416 0.998343031567643 0.999537459717592 7 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.752G>A rrs_n.752G>A 1 non_coding_transcript_exon_variant 1472597 0 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2104 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1756 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 12 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.753A>C rrs_n.753A>C 1 non_coding_transcript_exon_variant 1472598 0 0 0 0 10 13 10358 15595 0.000964506172839506 0.000462612020337809 0.00177304351401163 0.999167093798052 0.998576126182689 0.999556440358575 0.434782608695652 0.231914199538231 0.655053392547625 NA NA NA 0 0 0.24705263800047 NA NA NA NA 2060 2512 False False 1.15815348968467 0.454411471297039 2.86033204841706 0 0 0.000356074788245403 0.999167093798052 0.998576126182689 0.999556440358575 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 7 10 7729 11864 0.000904860392967942 0.000363875741427306 0.00186346392020999 0.999157823816742 0.998451755191613 0.9995960722577 0.411764705882352 0.184436961783946 0.670752846053242 NA NA NA 0 0 0.30849710781876 NA NA NA NA 1717 2071 False False 0 0 0 0 0 0 0 1.07449864148013 0.346978325153301 3.12865153549198 0 0 0.000477163835447126 0.999157823816742 0.998451755191613 0.9995960722577 204 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.753A>T rrs_n.753A>T 1 non_coding_transcript_exon_variant 1472598 0 0 0 0 3 12 10365 15596 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999231163505894 0.998657382918185 0.999602669866138 0.2 0.0433120051058366 0.480891133806853 NA NA NA 0 0 0.264648469397051 NA NA NA NA 2091 2512 False False 0.376169802219006 0.0681041402083858 1.39445373583362 0 0 0.000355834356021348 0.999231163505894 0.998657382918185 0.999602669866138 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 11 7734 11863 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999073606198416 0.998343031567643 0.999537459717592 0.153846153846153 0.0192066719825284 0.454471055676557 NA NA NA 0 0 0.284914152918154 NA NA NA NA 1745 2071 False False 0 0 0 0 0 0 0 0.278886616357524 0.0300333523224716 1.27842407058003 0 0 0.000476855424503066 0.999073606198416 0.998343031567643 0.999537459717592 10 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.754G>A rrs_n.754G>A 1 non_coding_transcript_exon_variant 1472599 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1761 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1456 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.754G>T rrs_n.754G>T 1 non_coding_transcript_exon_variant 1472599 1 0 0 0 0 4 10368 15604 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 2122 2512 False False 0 0 2.28044779470556 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1773 2071 False False 0 0 0 0 0 0 0 0 0 3.71438150990605 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 179 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.762G>A rrs_n.762G>A 1 non_coding_transcript_exon_variant 1472607 1 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2105 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1757 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 17 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.765G>A rrs_n.765G>A 1 non_coding_transcript_exon_variant 1472610 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.767G>T rrs_n.767G>T 1 non_coding_transcript_exon_variant 1472612 0 0 0 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1821 2512 False False Inf 0.282736080598822 Inf 0 0 0.000355800035063835 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1509 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0 0 0.000476855424503066 1 0.999689379610589 1 10 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.769G>A rrs_n.769G>A 1 non_coding_transcript_exon_variant 1472614 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1998 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1664 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.769G>T rrs_n.769G>T 1 non_coding_transcript_exon_variant 1472614 0 0 0 0 3 12 10365 15596 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999231163505894 0.998657382918185 0.999602669866138 0.2 0.0433120051058366 0.480891133806853 NA NA NA 0 0 0.264648469397051 NA NA NA NA 1953 2512 False False 0.376169802219006 0.0681041402083858 1.39445373583362 0 0 0.000355834356021348 0.999231163505894 0.998657382918185 0.999602669866138 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 11 7733 11863 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 0.999073606198416 0.998343031567643 0.999537459717592 0.214285714285714 0.0465792878898673 0.507975677048471 NA NA NA 0 0 0.284914152918154 NA NA NA NA 1627 2071 False False 0 0 0 0 0 0 0 0.418384021254834 0.0749239120687622 1.58455503072556 0 0 0.000476917074793532 0.999073606198416 0.998343031567643 0.999537459717592 10 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.-76T>G rrs_n.-76T>G 1 upstream_gene_variant 1471770 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2031 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1692 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.771G>A rrs_n.771G>A 1 non_coding_transcript_exon_variant 1472616 0 0 0 0 11 21 10357 15587 0.00106095679012345 0.000529741017552837 0.00189754996565939 0.998654536135315 0.997944046996364 0.999166949785744 0.34375 0.185719091716566 0.531931036280268 NA NA NA 0 0 0.161097615219079 NA NA NA NA 2027 2512 False False 0.788318919341416 0.343128178646541 1.71118651415261 0 0 0.000356109162232076 0.998654536135315 0.997944046996364 0.999166949785744 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 10 19 7726 11855 0.00129265770423991 0.000620048157733657 0.00237595446225449 0.99839986525181 0.997502314270442 0.999036348042965 0.344827586206896 0.179383649235111 0.543305727667943 NA NA NA 0 0 0.176466911806965 NA NA NA NA 1689 2071 False False 0 0 0 0 0 0 0 0.807594315843971 0.335249595134738 1.82664113857013 0 0 0.000477349073576999 0.99839986525181 0.997502314270442 0.999036348042965 173 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.-77G>C rrs_n.-77G>C 1 upstream_gene_variant 1471769 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.78_80delTCTinsCC rrs_n.78_80delTCTinsCC 1 non_coding_transcript_exon_variant 1471923 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1964 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1634 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 2 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.78T>C rrs_n.78T>C 1 non_coding_transcript_exon_variant 1471923 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1934 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1610 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 5 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.-78T>C rrs_n.-78T>C 1 upstream_gene_variant 1471768 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1967 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1636 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.799C>A rrs_n.799C>A 1 non_coding_transcript_exon_variant 1472644 1 8 0 8 1 9 10367 15599 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.99942337262942 0.998905665124108 0.999736296428239 0.1 0.00252857854446178 0.445016117028195 0 0 0.369416647552819 0 0 0.336267116879942 0 0 0.881759478732443 0.025372073888289 89 2512 False False 0.167186478462643 0.00381816513248207 1.20692977805764 0 0 0.000355765720726338 0.99942337262942 0.998905665124108 0.999736296428239 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 1 8 7735 11866 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999326259053394 0.998672895689377 0.999709083033384 0.111111111111111 0.00280913674659921 0.482496514917337 0 0 0.409616397225003 0 0 0.369416647552819 0 0 1.06472538339065 0.0472687580235552 84 2071 False False 0 0 0 0 0 0 0 0.191758241758241 0.00432517143892361 1.43088714399149 0 0 0.000476793790149404 0.999326259053394 0.998672895689377 0.999709083033384 2 3) Uncertain significance No change no 1 +Streptomycin rrs n.799C>T rrs_n.799C>T 1 non_coding_transcript_exon_variant 1472644 1 0 0 0 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2028 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1690 2071 False False 0 0 0 0 0 0 0 0 0 3.71438150990605 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 15 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.808C>T rrs_n.808C>T 1 non_coding_transcript_exon_variant 1472653 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 3 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.809G>A rrs_n.809G>A 1 non_coding_transcript_exon_variant 1472654 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1775 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1468 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.81_82dupCT rrs_n.81_82dupCT 1 non_coding_transcript_exon_variant 1471922 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1822 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1510 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.810G>A rrs_n.810G>A 1 non_coding_transcript_exon_variant 1472655 0 0 0 0 1 7 10367 15601 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999551512045105 0.999076163117038 0.999819666176692 0.125 0.0031597235312519 0.526509670875206 NA NA NA 0 0 0.409616397225003 NA NA NA NA 2123 2512 False False 0.214981603715084 0.00477381113707295 1.6738454938462 0 0 0.000355765720726338 0.999551512045105 0.999076163117038 0.999819666176692 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 4 7735 11870 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999663129526697 0.999137704464366 0.999908206750254 0.2 0.00505076337946806 0.716417936118089 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1774 2071 False False 0 0 0 0 0 0 0 0.383645765998707 0.00779364023519555 3.87797408017955 0 0 0.000476793790149404 0.999663129526697 0.999137704464366 0.999908206750254 35 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.810G>T rrs_n.810G>T 1 non_coding_transcript_exon_variant 1472655 1 1 0 1 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 58.6596525903968 1 973.5 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 0 0 0.000355765720726338 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 59.8088564761233 1 806.5 2071 False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 0 0 0.000476793790149404 0.999831564763348 0.99939168785815 0.999979601060482 48 3) Uncertain significance No change no 1 +Streptomycin rrs n.811dupT rrs_n.811dupT 1 non_coding_transcript_exon_variant 1472655 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.813G>A rrs_n.813G>A 1 non_coding_transcript_exon_variant 1472658 1 0 0 0 0 7 10368 15601 0 0 0.000355731413006942 0.999551512045105 0.999076163117038 0.999819666176692 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 2029 2512 False False 0 0 1.04426933597617 0 0 0.000355731413006942 0.999551512045105 0.999076163117038 0.999819666176692 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 7736 11870 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1691 2071 False False 0 0 0 0 0 0 0 0 0 2.32513012450998 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 31 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.814G>A rrs_n.814G>A 1 non_coding_transcript_exon_variant 1472659 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1892 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1574 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.815T>C rrs_n.815T>C 1 non_coding_transcript_exon_variant 1472660 0 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2061 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1718 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 48 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.816A>G rrs_n.816A>G 1 non_coding_transcript_exon_variant 1472661 1 0 0 0 0 8 10368 15600 0 0 0.000355731413006942 0.999487442337262 0.998990308225149 0.99977868883794 0 0 0.369416647552819 NA NA NA 0 0 0.369416647552819 NA NA NA NA 1863 2512 False False 0 0 0.881730950187969 0 0 0.000355731413006942 0.999487442337262 0.998990308225149 0.99977868883794 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 5 7736 11869 0 0 0.000476732171726368 0.999578911908371 0.999017596768841 0.999863260157969 0 0 0.521823750104981 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1548 2071 False False 0 0 0 0 0 0 0 0 0 1.67480496260254 0 0 0.000476732171726368 0.999578911908371 0.999017596768841 0.999863260157969 36 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.-81C>A rrs_n.-81C>A 1 upstream_gene_variant 1471765 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.81C>T rrs_n.81C>T 1 non_coding_transcript_exon_variant 1471926 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2044 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1704 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 3 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.820G>A rrs_n.820G>A 1 non_coding_transcript_exon_variant 1472665 1 0 0 0 0 6 10368 15602 0 0 0.000355731413006942 0.999615581752947 0.999163472525571 0.999858912630967 0 0 0.4592581264399 NA NA NA 0 0 0.4592581264399 NA NA NA NA 1745 2512 False False 0 0 1.27838118563185 0 0 0.000355731413006942 0.999615581752947 0.999163472525571 0.999858912630967 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 7736 11870 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1442 2071 False False 0 0 0 0 0 0 0 0 0 2.32513012450998 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.822T>C rrs_n.822T>C 1 non_coding_transcript_exon_variant 1472667 1 3 0 3 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.6429945931141 0.280491932584249 243 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.71438150990605 0.283358886007265 193.5 2071 False False 0 0 0 0 0 0 0 0 0 3.71438150990605 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.824_825insTAGA rrs_n.824_825insTAGA 1 non_coding_transcript_exon_variant 1472669 1 0 0 0 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1713 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1417 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.824_825insTAGG rrs_n.824_825insTAGG 1 non_coding_transcript_exon_variant 1472669 1 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2092 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1746 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.829T>G rrs_n.829T>G 1 non_coding_transcript_exon_variant 1472674 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1836 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1524 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 5 3) Uncertain significance No change no 1 +Streptomycin rrs n.-82C>T rrs_n.-82C>T 1 upstream_gene_variant 1471764 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1733 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.830dupT rrs_n.830dupT 1 non_coding_transcript_exon_variant 1472672 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.831C>T rrs_n.831C>T 1 non_coding_transcript_exon_variant 1472676 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.833_834delTTinsGCC rrs_n.833_834delTTinsGCC 1 non_coding_transcript_exon_variant 1472678 1 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1864 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1549 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.833T>G rrs_n.833T>G 1 non_coding_transcript_exon_variant 1472678 1 0 0 0 0 4 10368 15604 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 2014 2512 False False 0 0 2.28044779470556 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1676 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.834T>C rrs_n.834T>C 1 non_coding_transcript_exon_variant 1472679 1 0 0 0 0 4 10368 15604 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1746 2512 False False 0 0 2.28044779470556 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1443 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.837T>A rrs_n.837T>A 1 non_coding_transcript_exon_variant 1472682 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1874 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1556 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 18 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.837T>G rrs_n.837T>G 1 non_coding_transcript_exon_variant 1472682 0 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1906 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1585 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance No change no 1 +Streptomycin rrs n.838T>C rrs_n.838T>C 1 non_coding_transcript_exon_variant 1472683 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2062 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1719 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 18 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.839_845delGGGATCCinsA rrs_n.839_845delGGGATCCinsA 1 non_coding_transcript_exon_variant 1472684 1 0 0 0 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1694 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1400 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.839_845delGGGATCCinsTA rrs_n.839_845delGGGATCCinsTA 1 non_coding_transcript_exon_variant 1472684 1 0 0 0 0 4 10368 15604 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 2124 2512 False False 0 0 2.28044779470556 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1775 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.842A>G rrs_n.842A>G 1 non_coding_transcript_exon_variant 1472687 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 5 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.845C>T rrs_n.845C>T 1 non_coding_transcript_exon_variant 1472690 1 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1965 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Streptomycin rrs n.847T>C rrs_n.847T>C 1 non_coding_transcript_exon_variant 1472692 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 5 3) Uncertain significance No change no 1 +Streptomycin rrs n.850C>T rrs_n.850C>T 1 non_coding_transcript_exon_variant 1472695 1 0 0 0 0 7 10368 15601 0 0 0.000355731413006942 0.999551512045105 0.999076163117038 0.999819666176692 0 0 0.409616397225003 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1935 2512 False False 0 0 1.04426933597617 0 0 0.000355731413006942 0.999551512045105 0.999076163117038 0.999819666176692 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 4 7736 11870 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1611 2071 False False 0 0 0 0 0 0 0 0 0 2.32513012450998 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 1 3) Uncertain significance No change no 1 +Streptomycin rrs n.852T>C rrs_n.852T>C 1 non_coding_transcript_exon_variant 1472697 0 0 0 0 1 8 10367 15600 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999487442337262 0.998990308225149 0.99977868883794 0.111111111111111 0.00280913674659921 0.482496514917337 NA NA NA 0 0 0.369416647552819 NA NA NA NA 2077 2512 False False 0.188096845760586 0.00424281783599011 1.4034393515988 0 0 0.000355765720726338 0.999487442337262 0.998990308225149 0.99977868883794 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 5 7735 11869 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999578911908371 0.999017596768841 0.999863260157969 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1733 2071 False False 0 0 0 0 0 0 0 0.306890756302521 0.00649200912492085 2.74344385104518 0 0 0.000476793790149404 0.999578911908371 0.999017596768841 0.999863260157969 89 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.852T>G rrs_n.852T>G 1 non_coding_transcript_exon_variant 1472697 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1875 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1557 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.856T>A rrs_n.856T>A 1 non_coding_transcript_exon_variant 1472701 1 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1999 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.859C>T rrs_n.859C>T 1 non_coding_transcript_exon_variant 1472704 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.861C>T rrs_n.861C>T 1 non_coding_transcript_exon_variant 1472706 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2045 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1705 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 3 3) Uncertain significance No change no 1 +Streptomycin rrs n.863T>A rrs_n.863T>A 1 non_coding_transcript_exon_variant 1472708 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2078 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1734 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 24 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.868T>C rrs_n.868T>C 1 non_coding_transcript_exon_variant 1472713 0 0 0 0 6 29 10362 15579 0.000578703703703703 0.000212402724453782 0.00125916554902567 0.998141978472578 0.997332652594423 0.998755311644571 0.171428571428571 0.0656218011562506 0.336498300018197 NA NA NA 0 0 0.119444869069502 NA NA NA NA 1837 2512 False False 0.31106363436695 0.105573890263117 0.762889562331847 0 0 0.000355937358633142 0.998141978472578 0.997332652594423 0.998755311644571 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 24 7732 11850 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.997978777160182 0.99699406380332 0.998704548393253 0.142857142857142 0.0403356307970913 0.326652669315795 NA NA NA 0 0 0.142473597722525 NA NA NA NA 1525 2071 False False 0 0 0 0 0 0 0 0.255431971029487 0.0644248403683366 0.743934788231833 0 0 0.000476978741026985 0.997978777160182 0.99699406380332 0.998704548393253 336 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.869A>G rrs_n.869A>G 1 non_coding_transcript_exon_variant 1472714 0 0 0 0 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1924 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 0 0 0.000355765720726338 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1600 2071 False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 0 0 0.000476793790149404 0.999831564763348 0.99939168785815 0.999979601060482 126 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.87_89delAGAinsGG rrs_n.87_89delAGAinsGG 1 non_coding_transcript_exon_variant 1471932 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1728 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1429 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 2 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.871C>T rrs_n.871C>T 1 non_coding_transcript_exon_variant 1472716 0 0 0 0 6 28 10362 15580 0.000578703703703703 0.000212402724453782 0.00125916554902567 0.99820604818042 0.997408275859702 0.998807611281278 0.176470588235294 0.0676406526827571 0.345315131068133 NA NA NA 0 0 0.123436118500263 NA NA NA NA 2163 2512 False False 0.322193729837041 0.109055580688249 0.793456547063223 0 0 0.000355937358633142 0.99820604818042 0.997408275859702 0.998807611281278 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 23 7732 11851 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.998062994778507 0.99709495013346 0.998771720922747 0.148148148148148 0.0418873964737672 0.337310864024244 NA NA NA 0 0 0.148185128915224 NA NA NA NA 1809 2071 False False 0 0 0 0 0 0 0 0.266560201533997 0.0670133157973287 0.780652947291833 0 0 0.000476978741026985 0.998062994778507 0.99709495013346 0.998771720922747 330 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.872C>T rrs_n.872C>T 1 non_coding_transcript_exon_variant 1472717 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.876C>A rrs_n.876C>A 1 non_coding_transcript_exon_variant 1472721 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.878G>A rrs_n.878G>A 1 non_coding_transcript_exon_variant 1472723 1 38 33 5 50 5 10318 15603 0.00482253086419753 0.00358143095757199 0.006353021701969 0.999679651460789 0.999252573060182 0.999895975781355 0.909090909090909 0.800460384229499 0.969819132154186 0.868421052631579 0.719136154116246 0.955862559942085 0.868421052631579 0.719136154116246 0.955862559942085 9.98059701492537 3.86971756473997 32.7662259942567 2.8284026824522e-09 15 2512 True False 15.1221166892808 6.06342626980853 48.6253077400192 0.00318809776833156 0.00219552511638445 0.00447438764237245 0.999679651460789 0.999252573060182 0.999895975781355 1) Assoc w R 1) Assoc w R ALL 3) Uncertain significance 1 15 11 4 17 4 7719 11870 0.00219751809720785 0.00128064014327926 0.00351611538908953 0.999663129526697 0.999137704464366 0.999908206750254 0.809523809523809 0.580933958816472 0.945536431821593 0.733333333333333 0.448996758963029 0.922128453708956 0.733333333333333 0.448996758963029 0.922128453708956 4.22885088742065 1.25240686184675 18.207663235807 0.0140417850587118 62 2071 False False 0 0 0 0 0 0 0 6.53549682601373 2.13054573795088 26.7009534696226 0.00142302716688227 0.000710577328084509 0.00254475885717009 0.999663129526697 0.999137704464366 0.999908206750254 34 Assoc w R Evidence from ALL dataset only 2) Assoc w R - Interim DOWN from AwR to AwRI yes ALL only 3 +Streptomycin rrs n.887G>A rrs_n.887G>A 1 non_coding_transcript_exon_variant 1472732 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1729 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Streptomycin rrs n.887G>T rrs_n.887G>T 1 non_coding_transcript_exon_variant 1472732 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1730 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.888G>A rrs_n.888G>A 1 non_coding_transcript_exon_variant 1472733 0 0 0 0 3 19 10365 15589 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.998782675550999 0.998099646955 0.999266937052498 0.136363636363636 0.0290558511287467 0.349122097257408 NA NA NA 0 0 0.176466911806965 NA NA NA NA 2046 2512 False False 0.237474293548632 0.0450018373335028 0.807073878133986 0 0 0.000355834356021348 0.998782675550999 0.998099646955 0.999266937052498 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 17 7733 11857 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 0.998568300488462 0.997708696799157 0.999165768038889 0.15 0.0320709371854637 0.378926826545313 NA NA NA 0 0 0.195064322969093 NA NA NA NA 1706 2071 False False 0 0 0 0 0 0 0 0.270582149839115 0.0507940683627474 0.935989825969577 0 0 0.000476917074793532 0.998568300488462 0.997708696799157 0.999165768038889 347 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.888G>C rrs_n.888G>C 1 non_coding_transcript_exon_variant 1472733 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1786 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1477 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 23 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.889C>T rrs_n.889C>T 1 non_coding_transcript_exon_variant 1472734 0 0 0 0 5 10 10363 15598 0.000482253086419753 0.000156604214122162 0.00112505595550109 0.999359302921578 0.998822051949738 0.999692719453314 0.333333333333333 0.11824110336688 0.616196267458845 NA NA NA 0 0 0.30849710781876 NA NA NA NA 1714 2512 False False 0.752581298851683 0.201781230460037 2.41739213960686 0 0 0.000355903017804084 0.999359302921578 0.998822051949738 0.999692719453314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 7 7733 11867 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 0.999410476671719 0.998785736251934 0.999762949244471 0.3 0.0667395111777345 0.652452850059997 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1418 2071 False False 0 0 0 0 0 0 0 0.657682289261236 0.109739874070061 2.88202574760339 0 0 0.000476917074793532 0.999410476671719 0.998785736251934 0.999762949244471 43 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.891G>A rrs_n.891G>A 1 non_coding_transcript_exon_variant 1472736 1 6 0 6 4 7 10364 15601 0.000385802469135802 0.000105127872737001 0.000987510251175401 0.999551512045105 0.999076163117038 0.999819666176692 0.363636363636363 0.109263443819098 0.692095284988322 0 0 0.4592581264399 0 0 0.409616397225003 0 0 1.2787926888707 0.0875891141837731 130 2512 False False 0.860175332193857 0.184612886649235 3.38458769855359 0 0 0.000355868683600791 0.999551512045105 0.999076163117038 0.999819666176692 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 4 5 7732 11869 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.999578911908371 0.999017596768841 0.999863260157969 0.444444444444444 0.136995662265166 0.787991493221131 0 0 0.602364635616474 0 0 0.521823750104981 0 0 2.32613774624847 0.158671558694299 153 2071 False False 0 0 0 0 0 0 0 1.22803931712364 0.243597035514314 5.70658237719251 0 0 0.000476978741026985 0.999578911908371 0.999017596768841 0.999863260157969 5 3) Uncertain significance No change no 1 +Streptomycin rrs n.896G>A rrs_n.896G>A 1 non_coding_transcript_exon_variant 1472741 0 0 0 0 5 10 10363 15598 0.000482253086419753 0.000156604214122162 0.00112505595550109 0.999359302921578 0.998822051949738 0.999692719453314 0.333333333333333 0.11824110336688 0.616196267458845 NA NA NA 0 0 0.30849710781876 NA NA NA NA 2106 2512 False False 0.752581298851683 0.201781230460037 2.41739213960686 0 0 0.000355903017804084 0.999359302921578 0.998822051949738 0.999692719453314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 7 7733 11867 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 0.999410476671719 0.998785736251934 0.999762949244471 0.3 0.0667395111777345 0.652452850059997 NA NA NA 0 0 0.409616397225003 NA NA NA NA 1758 2071 False False 0 0 0 0 0 0 0 0.657682289261236 0.109739874070061 2.88202574760339 0 0 0.000476917074793532 0.999410476671719 0.998785736251934 0.999762949244471 43 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.897C>G rrs_n.897C>G 1 non_coding_transcript_exon_variant 1472742 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2079 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1735 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 23 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.897C>T rrs_n.897C>T 1 non_coding_transcript_exon_variant 1472742 0 0 0 0 5 22 10363 15586 0.000482253086419753 0.000156604214122162 0.00112505595550109 0.998590466427473 0.997866722379978 0.999116448603187 0.185185185185185 0.0630000065376768 0.380829879093994 NA NA NA 0 0 0.154372512815574 NA NA NA NA 1876 2512 False False 0.3418192345144 0.101104780742684 0.925486615324044 0 0 0.000355903017804084 0.998590466427473 0.997866722379978 0.999116448603187 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 19 7732 11855 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.99839986525181 0.997502314270442 0.999036348042965 0.17391304347826 0.0495076453057934 0.387811889954797 NA NA NA 0 0 0.176466911806965 NA NA NA NA 1558 2071 False False 0 0 0 0 0 0 0 0.322787050398889 0.0798464157296627 0.971812973072417 0 0 0.000476978741026985 0.99839986525181 0.997502314270442 0.999036348042965 379 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.899A>G rrs_n.899A>G 1 non_coding_transcript_exon_variant 1472744 0 0 0 0 11 33 10357 15575 0.00106095679012345 0.000529741017552837 0.00189754996565939 0.997885699641209 0.997032005789816 0.998544179730394 0.25 0.131927437933646 0.403380407735858 NA NA NA 0 0 0.105762810074579 NA NA NA NA 2147 2512 False False 0.501271281902738 0.228445829451788 1.01732698827949 0 0 0.000356109162232076 0.997885699641209 0.997032005789816 0.998544179730394 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 9 28 7727 11846 0.00116339193381592 0.000532110502771461 0.00220732634615895 0.997641906686878 0.996593688246593 0.998432509782957 0.243243243243243 0.117725174307107 0.411991692423913 NA NA NA 0 0 0.123436118500263 NA NA NA NA 1794 2071 False False 0 0 0 0 0 0 0 0.492771173436373 0.204452180484119 1.07494334409187 0 0 0.00047728731155563 0.997641906686878 0.996593688246593 0.998432509782957 407 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.89A>G rrs_n.89A>G 1 non_coding_transcript_exon_variant 1471934 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1838 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1526 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 6 3) Uncertain significance No change no 1 +Streptomycin rrs n.-89T>C rrs_n.-89T>C 1 upstream_gene_variant 1471757 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.905C>A rrs_n.905C>A 1 non_coding_transcript_exon_variant 1472750 1 6 6 0 6 0 10362 15608 0.000578703703703703 0.000212402724453782 0.00125916554902567 1 0.99976368249849 1 1 0.540741873560099 1 1 0.540741873560099 1 1 0.540741873560099 1 Inf 1.77302352643969 Inf 0.00403978870377798 53 2512 False False Inf 1.77302352643969 Inf 0.000578703703703703 0.000212402724453782 0.00125916554902567 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.288279755767314 Inf 0.155612234482449 125.5 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 9 3) Uncertain significance No change no 1 +Streptomycin rrs n.905C>G rrs_n.905C>G 1 non_coding_transcript_exon_variant 1472750 1 5 3 2 7 2 10361 15606 0.000675154320987654 0.000271488767107418 0.00139057803317028 0.999871860584315 0.999537193839207 0.999984481345552 0.777777777777777 0.399906426283687 0.971855026522101 0.6 0.146632799634673 0.947255049473683 0.6 0.146632799634673 0.947255049473683 2.25933790174693 0.258757811555492 27.0581096782256 0.394138570913651 284 2512 False False 5.27178843740951 1.00343633455286 51.9980864983252 0.000289463527595522 5.96983169050341e-05 0.000845699922446725 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 3 1 6 1 7730 11873 0.00077559462254395 0.000284681048736677 0.00168737281383633 0.999915782381674 0.999530859783396 0.999997867796783 0.857142857142857 0.421276802956804 0.996389703138099 0.75 0.194120449683243 0.99369053679029 0.75 0.194120449683243 0.99369053679029 4.60789133247089 0.369878165781647 241.606415901394 0.307265342568572 212 2071 False False 0 0 0 0 0 0 0 9.21578266494178 1.11767707530695 423.06722176879 0.000387947756368809 8.00113005907662e-05 0.00113332526638003 0.999915782381674 0.999530859783396 0.999997867796783 6 3) Uncertain significance No change no 1 +Streptomycin rrs n.905C>T rrs_n.905C>T 1 non_coding_transcript_exon_variant 1472750 0 0 0 0 3 0 10365 15608 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 1 0.99976368249849 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1877 2512 False False Inf 0.622129167636411 Inf 0 0 0.000355834356021348 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1559 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0 0 0.000476855424503066 1 0.999689379610589 1 2 3) Uncertain significance No change no 1 +Streptomycin rrs n.906A>G rrs_n.906A>G 1 non_coding_transcript_exon_variant 1472751 1 32 22 10 66 11 10302 15597 0.00636574074074074 0.00492658380030099 0.00809175853824217 0.999295233213736 0.998739328260189 0.999648132128855 0.857142857142857 0.758749387114242 0.926469985897525 0.6875 0.49992241836783 0.838815275911799 0.666666666666666 0.481732527512417 0.820394865067439 3.33075131042516 1.51268408843473 7.88216147580847 0.0016216562919543 47 2512 False False 9.08386721025043 4.75834067444671 19.0849074779681 0.0021309569934134 0.0013359262707262 0.00322452731514267 0.999295233213736 0.998739328260189 0.999648132128855 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 15 12 3 45 3 7691 11871 0.00581695966907962 0.00424600142655946 0.00777589053158156 0.999747347145022 0.999261820436506 0.999947893876346 0.9375 0.828040069209429 0.986920755590447 0.8 0.519108866193147 0.956687994894163 0.8 0.519108866193147 0.956687994894163 6.17396957482772 1.66527572034385 34.0739643693022 0.0021727599702468 42 2071 False False 0 0 0 0 0 0 0 23.1523859056039 7.42681273366184 116.850838264903 0.00155783460989224 0.000805206797209753 0.00271964067785065 0.999747347145022 0.999261820436506 0.999947893876346 72 3) Uncertain significance No change no 1 +Streptomycin rrs n.907A>C rrs_n.907A>C 1 non_coding_transcript_exon_variant 1472752 1 2 2 0 3 0 10365 15608 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 1 0.99976368249849 1 1 0.292401773821286 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.282763354911628 Inf 0.159283177454496 169.5 2512 False False Inf 0.622129167636411 Inf 0.000192919841805729 2.33643418036207e-05 0.000696717215522511 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 2 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.288279755767314 Inf 0.155612234482449 125.5 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 3) Uncertain significance No change no 1 +Streptomycin rrs n.907A>T rrs_n.907A>T 1 non_coding_transcript_exon_variant 1472752 1 2 2 0 4 0 10364 15608 0.000385802469135802 0.000105127872737001 0.000987510251175401 1 0.99976368249849 1 1 0.397635364383525 1 1 0.158113883008419 1 1 0.158113883008419 1 Inf 0.282790634486965 Inf 0.159264711492024 168 2512 False False Inf 0.993868422549659 Inf 0.000192938452633609 2.33665958259919e-05 0.00069678441035516 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0393613144801391 Inf 0.394461726758121 237.5 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0.000129282482223658 3.27314370392442e-06 0.000720103058325324 1 0.999689379610589 1 4 3) Uncertain significance No change no 1 +Streptomycin rrs n.908_909insT rrs_n.908_909insT 1 non_coding_transcript_exon_variant 1472753 0 0 0 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1925 2512 False False Inf 0.282736080598822 Inf 0 0 0.000355800035063835 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1601 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.908A>C rrs_n.908A>C 1 non_coding_transcript_exon_variant 1472753 1 3 0 3 22 4 10346 15604 0.00212191358024691 0.00133025485608362 0.00321085044734721 0.999743721168631 0.999343955596995 0.999930168370675 0.846153846153846 0.651321214464638 0.956436523461076 0 0 0.707598226178713 0 0 0.602364635616474 0 0 3.65050851700411 0.28079158542928 270 2512 False False 8.29518654552484 2.81599049314491 33.1209071976806 0 0 0.00035648771456966 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 13 2 7723 11872 0.00168045501551189 0.000895065386794453 0.00287191489837179 0.999831564763348 0.99939168785815 0.999979601060482 0.866666666666666 0.595397303396627 0.983424086559916 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.18650048433984 0.522409090634959 467 2071 False False 0 0 0 0 0 0 0 9.99197203159394 2.26109098835743 91.2303219185863 0 0 0.000477534455584038 0.999831564763348 0.99939168785815 0.999979601060482 18 3) Uncertain significance No change no 1 +Streptomycin rrs n.908A>G rrs_n.908A>G 1 non_coding_transcript_exon_variant 1472753 0 0 0 0 4 0 10364 15608 0.000385802469135802 0.000105127872737001 0.000987510251175401 1 0.99976368249849 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 1823 2512 False False Inf 0.993868422549659 Inf 0 0 0.000355868683600791 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1511 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0 0 0.000476855424503066 1 0.999689379610589 1 4 3) Uncertain significance No change no 1 +Streptomycin rrs n.908A>T rrs_n.908A>T 1 non_coding_transcript_exon_variant 1472753 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2148 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1795 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.909G>T rrs_n.909G>T 1 non_coding_transcript_exon_variant 1472754 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1865 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.912A>G rrs_n.912A>G 1 non_coding_transcript_exon_variant 1472757 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.-91C>A rrs_n.-91C>A 1 upstream_gene_variant 1471755 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.-91C>G rrs_n.-91C>G 1 upstream_gene_variant 1471755 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.922G>A rrs_n.922G>A 1 non_coding_transcript_exon_variant 1472767 0 0 0 0 8 17 10360 15591 0.000771604938271604 0.00033318123262376 0.00151980017311994 0.998910814966683 0.998256680139026 0.999365385605091 0.32 0.149495422613569 0.535000717497372 NA NA NA 0 0 0.195064322969093 NA NA NA NA 1907 2512 False False 0.708198955257778 0.26444994965303 1.73218043351567 0 0 0.000356006060176228 0.998910814966683 0.998256680139026 0.999365385605091 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 7 15 7729 11859 0.000904860392967942 0.000363875741427306 0.00186346392020999 0.998736735725113 0.997917292278642 0.999292793629768 0.318181818181818 0.138646521553797 0.54872442757377 NA NA NA 0 0 0.218019360910534 NA NA NA NA 1586 2071 False False 0 0 0 0 0 0 0 0.716030534351145 0.246859413520769 1.86675630284717 0 0 0.000477163835447126 0.998736735725113 0.997917292278642 0.999292793629768 56 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.923C>T rrs_n.923C>T 1 non_coding_transcript_exon_variant 1472768 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2000 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1665 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance No change no 1 +Streptomycin rrs n.924C>T rrs_n.924C>T 1 non_coding_transcript_exon_variant 1472769 1 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2125 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1776 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.929C>T rrs_n.929C>T 1 non_coding_transcript_exon_variant 1472774 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.-92T>G rrs_n.-92T>G 1 upstream_gene_variant 1471754 0 0 0 0 1 3 10367 15605 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999807790876473 0.99943838714673 0.999960360103688 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2094 2512 False False 0.501752355229735 0.00956153582768186 6.25014259670444 0 0 0.000355765720726338 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1748 2071 False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 0 0 0.000476793790149404 0.999831564763348 0.99939168785815 0.999979601060482 4 3) Uncertain significance No change no 1 +Streptomycin rrs n.93_94insG rrs_n.93_94insG 1 non_coding_transcript_exon_variant 1471938 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.933C>G rrs_n.933C>G 1 non_coding_transcript_exon_variant 1472778 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1787 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1478 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.934G>A rrs_n.934G>A 1 non_coding_transcript_exon_variant 1472779 0 0 0 0 6 0 10362 15608 0.000578703703703703 0.000212402724453782 0.00125916554902567 1 0.99976368249849 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 1731 2512 False False Inf 1.77302352643969 Inf 0 0 0.000355937358633142 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 5 0 7731 11874 0.000646328852119958 0.0002098934625097 0.00150766595359595 1 0.999689379610589 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 1430 2071 False False 0 0 0 0 0 0 0 Inf 1.40693962335604 Inf 0 0 0.000477040423209609 1 0.999689379610589 1 8 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.935G>A rrs_n.935G>A 1 non_coding_transcript_exon_variant 1472780 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 2 3) Uncertain significance No change no 1 +Streptomycin rrs n.936C>T rrs_n.936C>T 1 non_coding_transcript_exon_variant 1472781 0 0 0 0 16 39 10352 15569 0.0015432098765432 0.000882326976774945 0.00250486960174422 0.997501281394156 0.996585736213267 0.998222581884164 0.29090909090909 0.176299657358236 0.428982582556114 NA NA NA 0 0 0.0902511009603342 NA NA NA NA 1954 2512 False False 0.617009471723536 0.321720569705489 1.13058864889063 0 0 0.000356281131763187 0.997501281394156 0.996585736213267 0.998222581884164 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 10 32 7726 11842 0.00129265770423991 0.000620048157733657 0.00237595446225449 0.997305036213576 0.99619762638504 0.99815593879969 0.238095238095238 0.120516186492179 0.394502429021575 NA NA NA 0 0 0.108881160679352 NA NA NA NA 1628 2071 False False 0 0 0 0 0 0 0 0.47898330313228 0.209904175550674 0.999398855282395 0 0 0.000477349073576999 0.997305036213576 0.99619762638504 0.99815593879969 484 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.-93C>T rrs_n.-93C>T 1 upstream_gene_variant 1471753 1 3 0 3 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.6429945931141 0.280491932584249 243 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.71438150990605 0.283358886007265 193.5 2071 False False 0 0 0 0 0 0 0 0 0 3.71438150990605 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.93T>A rrs_n.93T>A 1 non_coding_transcript_exon_variant 1471938 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2063 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1720 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.93T>G rrs_n.93T>G 1 non_coding_transcript_exon_variant 1471938 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.941C>T rrs_n.941C>T 1 non_coding_transcript_exon_variant 1472786 0 0 0 0 5 1 10363 15607 0.000482253086419753 0.000156604214122162 0.00112505595550109 0.999935930292158 0.99964307871082 0.999998377896754 0.833333333333333 0.358765421002325 0.99578925548551 NA NA NA 0 0 0.975 NA NA NA NA 1801 2512 False False 7.53015536041686 0.842353453161053 355.554202953959 0 0 0.000355903017804084 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 1 7732 11873 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.999915782381674 0.999530859783396 0.999997867796783 0.8 0.28358206388191 0.994949236620532 NA NA NA 0 0 0.975 NA NA NA NA 1490 2071 False False 0 0 0 0 0 0 0 6.14226590791515 0.607630898004113 302.048561734113 0 0 0.000476978741026985 0.999915782381674 0.999530859783396 0.999997867796783 8 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.945T>C rrs_n.945T>C 1 non_coding_transcript_exon_variant 1472790 1 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1747 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1444 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 89 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.948A>C rrs_n.948A>C 1 non_coding_transcript_exon_variant 1472793 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2093 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1747 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 5 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.948A>T rrs_n.948A>T 1 non_coding_transcript_exon_variant 1472793 0 0 0 0 16 39 10352 15569 0.0015432098765432 0.000882326976774945 0.00250486960174422 0.997501281394156 0.996585736213267 0.998222581884164 0.29090909090909 0.176299657358236 0.428982582556114 NA NA NA 0 0 0.0902511009603342 NA NA NA NA 1966 2512 False False 0.617009471723536 0.321720569705489 1.13058864889063 0 0 0.000356281131763187 0.997501281394156 0.996585736213267 0.998222581884164 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 10 32 7726 11842 0.00129265770423991 0.000620048157733657 0.00237595446225449 0.997305036213576 0.99619762638504 0.99815593879969 0.238095238095238 0.120516186492179 0.394502429021575 NA NA NA 0 0 0.108881160679352 NA NA NA NA 1635 2071 False False 0 0 0 0 0 0 0 0.47898330313228 0.209904175550674 0.999398855282395 0 0 0.000477349073576999 0.997305036213576 0.99619762638504 0.99815593879969 479 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.958T>A rrs_n.958T>A 1 non_coding_transcript_exon_variant 1472803 0 0 0 0 13 33 10355 15575 0.00125385802469135 0.000667790166179422 0.00214318097672708 0.997885699641209 0.997032005789816 0.998544179730394 0.282608695652173 0.159866701924902 0.43460407778425 NA NA NA 0 0 0.105762810074579 NA NA NA NA 2126 2512 False False 0.592525935355486 0.286057657076763 1.15681633546375 0 0 0.000356177930119202 0.997885699641209 0.997032005789816 0.998544179730394 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 10 28 7726 11846 0.00129265770423991 0.000620048157733657 0.00237595446225449 0.997641906686878 0.996593688246593 0.998432509782957 0.263157894736842 0.134033723024973 0.431008243702239 NA NA NA 0 0 0.123436118500263 NA NA NA NA 1777 2071 False False 0 0 0 0 0 0 0 0.547594393698457 0.237184908845198 1.16228056848215 0 0 0.000477349073576999 0.997641906686878 0.996593688246593 0.998432509782957 457 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.958T>C rrs_n.958T>C 1 non_coding_transcript_exon_variant 1472803 0 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1981 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1648 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 6 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.970A>C rrs_n.970A>C 1 non_coding_transcript_exon_variant 1472815 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance No change no 1 +Streptomycin rrs n.979T>A rrs_n.979T>A 1 non_coding_transcript_exon_variant 1472824 1 0 0 0 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2164 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1810 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 32 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.980G>A rrs_n.980G>A 1 non_coding_transcript_exon_variant 1472825 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1802 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 30 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.981G>A rrs_n.981G>A 1 non_coding_transcript_exon_variant 1472826 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1762 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.982G>T rrs_n.982G>T 1 non_coding_transcript_exon_variant 1472827 1 0 0 0 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1982 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1649 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.983T>C rrs_n.983T>C 1 non_coding_transcript_exon_variant 1472828 1 2 0 2 0 5 10368 15603 0 0 0.000355731413006942 0.999679651460789 0.999252573060182 0.999895975781355 0 0 0.521823750104981 0 0 0.841886116991581 0 0 0.521823750104981 0 0 8.01410691564285 0.520309356547321 431 2512 False False 0 0 1.64266120859479 0 0 0.000355731413006942 0.999679651460789 0.999252573060182 0.999895975781355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 59.801132462225 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 39 3) Uncertain significance No change no 1 +Streptomycin rrs n.98T>C rrs_n.98T>C 1 non_coding_transcript_exon_variant 1471943 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1908 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1587 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 1 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.991_992delGCinsCCTTTG rrs_n.991_992delGCinsCCTTTG 1 non_coding_transcript_exon_variant 1472836 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2138 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.991_996delGCACAGinsCCTCT rrs_n.991_996delGCACAGinsCCTCT 1 non_coding_transcript_exon_variant 1472836 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1732 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1431 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.992C>T rrs_n.992C>T 1 non_coding_transcript_exon_variant 1472837 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1936 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.994C>T rrs_n.994C>T 1 non_coding_transcript_exon_variant 1472839 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.996_1002delGGACGCGinsAC rrs_n.996_1002delGGACGCGinsAC 1 non_coding_transcript_exon_variant 1472841 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1893 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.996_1003delGGACGCGTinsACC rrs_n.996_1003delGGACGCGTinsACC 1 non_coding_transcript_exon_variant 1472841 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2080 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.996G>T rrs_n.996G>T 1 non_coding_transcript_exon_variant 1472841 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin rrs n.99G>A rrs_n.99G>A 1 non_coding_transcript_exon_variant 1471944 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1850 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1537 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin rrs n.-9G>T rrs_n.-9G>T 1 upstream_gene_variant 1471837 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c c.1002C>T Rv1258c_c.1002C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.1029T>C Rv1258c_c.1029T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 35 391 10333 15217 0.00337577160493827 0.0023524409007714 0.00469178345395733 0.974948744233726 0.972374611273734 0.977343715551915 0.0821596244131455 0.0578929152336947 0.112412810599978 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.131823821723809 0.0904185718326827 0.186691438996838 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 34 372 7702 11502 0.00439503619441571 0.00304555303303915 0.00613625663203014 0.968671045982819 0.965378418004989 0.971731179844124 0.083743842364532 0.0586911142428828 0.115058191407047 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 0 0.136491569010144 0.0930001373565769 0.194422994195776 NA NA NA NA NA NA 380 5) Not assoc w R Now listed Silent mutation no 0 +Streptomycin Rv1258c c.1038C>T Rv1258c_c.1038C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.17274275317631 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.103T>C Rv1258c_c.103T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 8 10367 15600 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999487442337262 0.998990308225149 0.99977868883794 0.111111111111111 0.00280913674659921 0.482496514917337 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.188096845760586 0.00424281783599011 1.4034393515988 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 8 7735 11866 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999326259053394 0.998672895689377 0.999709083033384 0.111111111111111 0.00280913674659921 0.482496514917337 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.191758241758241 0.00432517143892361 1.43088714399149 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.1059G>T Rv1258c_c.1059G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.1062G>A Rv1258c_c.1062G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.1065G>A Rv1258c_c.1065G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 2 2 10366 15606 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999871860584315 0.999537193839207 0.999984481345552 0.5 0.067585986488543 0.932414013511457 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.50549874590005 0.10909391082996 20.7696540777406 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.1086G>A Rv1258c_c.1086G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.17274275317631 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.1092G>A Rv1258c_c.1092G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.1107A>C Rv1258c_c.1107A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.1110G>C Rv1258c_c.1110G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.1137G>T Rv1258c_c.1137G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.17274275317631 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.114G>A Rv1258c_c.114G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.1152A>G Rv1258c_c.1152A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.1176G>T Rv1258c_c.1176G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 8 11 10360 15597 0.000771604938271604 0.00033318123262376 0.00151980017311994 0.999295233213736 0.998739328260189 0.999648132128855 0.421052631578947 0.202521438977162 0.665002155988264 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.09491049491049 0.382183879836686 2.98972267481287 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 6 9 7730 11865 0.00077559462254395 0.000284681048736677 0.00168737281383633 0.999242041435068 0.998561648359028 0.999653356368186 0.4 0.163364323859513 0.677130233793718 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.02328589909443 0.299562273515437 3.22060276670201 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.1182G>C Rv1258c_c.1182G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.1203C>G Rv1258c_c.1203C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.17274275317631 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.1209G>A Rv1258c_c.1209G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.120C>T Rv1258c_c.120C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 0 10364 15608 0.000385802469135802 0.000105127872737001 0.000987510251175401 1 0.99976368249849 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.993868422549659 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 4 0 7732 11874 0.000517063081695967 0.000140899683864147 0.00132335286075948 1 0.999689379610589 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.01342344657205 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.1230C>T Rv1258c_c.1230C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.1251G>A Rv1258c_c.1251G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.162G>T Rv1258c_c.162G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.168G>A Rv1258c_c.168G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.-16T>C Rv1258c_c.-16T>C 1 upstream_gene_variant 1407356 1 2 0 2 5 3 10363 15605 0.000482253086419753 0.000156604214122162 0.00112505595550109 0.999807790876473 0.99943838714673 0.999960360103688 0.625 0.244863216366551 0.914766585862746 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.01900139918718 0.52036844439372 560 2512 False False 2.50973012962784 0.48813575589439 16.1645252811411 0 0 0.000355903017804084 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 2 3 7734 11871 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999747347145022 0.999261820436506 0.999947893876346 0.4 0.0527449505263169 0.853367200365326 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.1741678193458 0.52225683315318 459 2071 False False 0 0 0 0 0 0 0 1.02327385570209 0.0854221600622099 8.93608975066686 0 0 0.000476855424503066 0.999747347145022 0.999261820436506 0.999947893876346 10 3) Uncertain significance No change no 1 +Streptomycin Rv1258c c.186C>T Rv1258c_c.186C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.752676762805054 0.0127620362920002 14.460605698152 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.198C>T Rv1258c_c.198C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.231G>A Rv1258c_c.231G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.-23C>T Rv1258c_c.-23C>T 1 upstream_gene_variant 1407363 2 1 1 0 4 0 10364 15608 0.000385802469135802 0.000105127872737001 0.000987510251175401 1 0.99976368249849 1 1 0.397635364383525 1 1 0.025 1 1 0.025 1 Inf 0.0386109701110651 Inf 0.399068263196396 295 2512 False False Inf 0.993868422549659 Inf 9.64785335262904e-05 2.44262200321851e-06 0.000537425452634802 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 1 0 3 0 7733 11874 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 1 0.999689379610589 1 1 0.292401773821286 1 1 0.025 1 1 0.025 1 Inf 0.0393664039281761 Inf 0.394430844553243 227 2071 False False 0 0 0 0 0 0 0 Inf 0.634338273987677 Inf 0.00012929919834497 3.27356691808869e-06 0.000720196139555935 1 0.999689379610589 1 12 3) Uncertain significance No change no 1 +Streptomycin Rv1258c c.249T>C Rv1258c_c.249T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.-25G>A Rv1258c_c.-25G>A 1 upstream_gene_variant 1407365 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c c.-25G>T Rv1258c_c.-25G>T 1 upstream_gene_variant 1407365 1 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1340 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1100 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c c.270C>T Rv1258c_c.270C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.271C>T Rv1258c_c.271C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.276G>A Rv1258c_c.276G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.6429945931141 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.17274275317631 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.279G>A Rv1258c_c.279G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 19 17 10349 15591 0.00183256172839506 0.00110367119743855 0.00286029933187508 0.998910814966683 0.998256680139026 0.999365385605091 0.527777777777777 0.35486379853731 0.695949411283735 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.68376029511234 0.828225521541299 3.44994038761532 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 19 9 7717 11865 0.00245604963805584 0.00147932993205813 0.00383278019133476 0.999242041435068 0.998561648359028 0.999653356368186 0.678571428571428 0.476483593290381 0.841223962113846 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.2458641095417 1.39844683634795 8.15000975734156 NA NA NA NA NA NA 11 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.297C>T Rv1258c_c.297C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.282736080598822 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.-30G>A Rv1258c_c.-30G>A 1 upstream_gene_variant 1407370 1 1 0 1 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 58.6540000158548 1 973.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 59.801132462225 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c c.31C>T Rv1258c_c.31C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.334C>T Rv1258c_c.334C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.-33A>G Rv1258c_c.-33A>G 1 upstream_gene_variant 1407373 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1365 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1120 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c c.-33A>T Rv1258c_c.-33A>T 1 upstream_gene_variant 1407373 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c c.342C>T Rv1258c_c.342C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.351C>T Rv1258c_c.351C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.354G>A Rv1258c_c.354G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 10368 15604 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.28044779470556 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 7736 11870 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.32513012450998 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.357A>C Rv1258c_c.357A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.-36delC Rv1258c_c.-36delC 1 upstream_gene_variant 1407375 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance No change no 1 +Streptomycin Rv1258c c.378G>A Rv1258c_c.378G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.384G>A Rv1258c_c.384G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.17274275317631 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.390G>A Rv1258c_c.390G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.3G>A Rv1258c_c.3G>A 1 initiator_codon_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.17274275317631 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.-40C>T Rv1258c_c.-40C>T 1 upstream_gene_variant 1407380 1 4 0 4 1 4 10367 15604 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999743721168631 0.999343955596995 0.999930168370675 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.28066788567474 0.155711983833633 162 2512 False False 0.376290151442075 0.00764455959995544 3.80334957923739 0 0 0.000355765720726338 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 5 3) Uncertain significance No change no 1 +Streptomycin Rv1258c c.-41G>A Rv1258c_c.-41G>A 1 upstream_gene_variant 1407381 1 1 0 1 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 58.6540000158548 1 973.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 59.801132462225 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c c.426C>T Rv1258c_c.426C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.-42G>A Rv1258c_c.-42G>A 1 upstream_gene_variant 1407382 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1381 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c c.444G>A Rv1258c_c.444G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.456G>A Rv1258c_c.456G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.459C>A Rv1258c_c.459C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.498G>A Rv1258c_c.498G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.6429945931141 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.71438150990605 NA NA NA NA NA NA 8 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.504T>A Rv1258c_c.504T>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.528T>C Rv1258c_c.528T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 22 0 10346 15608 0.00212191358024691 0.00133025485608362 0.00321085044734721 1 0.99976368249849 1 1 0.845627487184425 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 8.25922674786928 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 15 0 7721 11874 0.00193898655635987 0.00108562946918638 0.00319605008438842 1 0.999689379610589 1 1 0.781980639089466 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 5.51360376948071 Inf NA NA NA NA NA NA 30 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.531C>G Rv1258c_c.531C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.-54C>G Rv1258c_c.-54C>G 1 upstream_gene_variant 1407394 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1369 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1124 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 1 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c c.552C>T Rv1258c_c.552C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.555C>T Rv1258c_c.555C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.594G>A Rv1258c_c.594G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.612G>A Rv1258c_c.612G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.633G>A Rv1258c_c.633G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.282736080598822 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.-64_-56delTGCGGCAGC Rv1258c_c.-64_-56delTGCGGCAGC 1 upstream_gene_variant 1407395 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1403 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c c.666G>A Rv1258c_c.666G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.697C>T Rv1258c_c.697C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.69T>C Rv1258c_c.69T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.50544998553101 0.0191837380556942 118.074698097101 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.705C>A Rv1258c_c.705C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.752676762805054 0.0127620362920002 14.460605698152 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.738G>A Rv1258c_c.738G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.753C>T Rv1258c_c.753C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 10368 15604 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.28044779470556 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 7736 11870 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.32513012450998 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.771G>A Rv1258c_c.771G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.774G>A Rv1258c_c.774G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.813C>T Rv1258c_c.813C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.17274275317631 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.837C>A Rv1258c_c.837C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.846T>G Rv1258c_c.846T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 5 0 10363 15608 0.000482253086419753 0.000156604214122162 0.00112505595550109 1 0.99976368249849 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.37979907306709 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 5 0 7731 11874 0.000646328852119958 0.0002098934625097 0.00150766595359595 1 0.999689379610589 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.40693962335604 Inf NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.849C>A Rv1258c_c.849C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.50544998553101 0.0191837380556942 118.074698097101 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.852C>T Rv1258c_c.852C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.855T>G Rv1258c_c.855T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.882G>A Rv1258c_c.882G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 6 10368 15602 0 0 0.000355731413006942 0.999615581752947 0.999163472525571 0.999858912630967 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.27838118563185 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 6 7736 11868 0 0 0.000476732171726368 0.999494694290045 0.998900489118281 0.999814539856352 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.30338194607257 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.882G>C Rv1258c_c.882G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.-8C>T Rv1258c_c.-8C>T 1 upstream_gene_variant 1407348 0 0 0 0 3 0 10365 15608 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 1 0.99976368249849 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1388 2512 False False Inf 0.622129167636411 Inf 0 0 0.000355834356021348 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 7733 11874 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 1 0.999689379610589 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1139 2071 False False 0 0 0 0 0 0 0 Inf 0.634338273987677 Inf 0 0 0.000476917074793532 1 0.999689379610589 1 8 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c c.900G>A Rv1258c_c.900G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.752676762805054 0.0127620362920002 14.460605698152 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.918G>A Rv1258c_c.918G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.282736080598822 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.918G>C Rv1258c_c.918G>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.930A>C Rv1258c_c.930A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.930A>G Rv1258c_c.930A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.282736080598822 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.939C>T Rv1258c_c.939C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.942C>T Rv1258c_c.942C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.17274275317631 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.951G>A Rv1258c_c.951G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.960G>A Rv1258c_c.960G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.967C>T Rv1258c_c.967C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.975C>T Rv1258c_c.975C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.978A>G Rv1258c_c.978A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.981C>T Rv1258c_c.981C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 1 3 10367 15605 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999807790876473 0.99943838714673 0.999960360103688 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.501752355229735 0.00956153582768186 6.25014259670444 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 3.71438150990605 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c c.987G>A Rv1258c_c.987G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv1258c deletion Rv1258c_deletion 1 feature_ablation (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1358 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1115 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 3 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c LoF Rv1258c_LoF 1 LoF (see "Genomic_coordinates" sheet) 1 2942 132 2810 5140 3353 5228 12255 0.495756172839506 0.486086291323424 0.50542843913389 0.78517426960533 0.778646200497714 0.791595888563418 0.605204285882491 0.594715039706988 0.615621302427181 0.044867437117607 0.0376732215303543 0.0529833448077575 0.0378766140602582 0.0317856285470081 0.0447576120662331 0.110114712184868 0.0915016668676371 0.131588041252385 9.76424340222372e-242 3 2512 True False 3.59341438686957 3.40224012069309 3.79494562602833 0.0246268656716417 0.0206449107875721 0.0291371776156434 0.78517426960533 0.778646200497714 0.791595888563418 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2218 105 2113 4051 2515 3685 9359 0.52365563598759 0.512454410731023 0.534839027764408 0.788192689910729 0.78073123395283 0.795512603085754 0.616966189460859 0.605081820279517 0.628746580318931 0.0473399458972046 0.0388799598663909 0.0570198801894238 0.0400763358778625 0.0328932806161084 0.0483087073856268 0.126206509936228 0.10234848703563 0.154194022751817 5.24039412522936e-161 3 2071 True False 0 0 0 0 0 0 0 4.09087499426777 3.84068056641577 4.35777520821488 0.0277044854881266 0.0227141715493239 0.0334396733727802 0.788192689910729 0.78073123395283 0.795512603085754 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Ala113Glu Rv1258c_p.Ala113Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1393 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1144 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Ala113Val Rv1258c_p.Ala113Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.01513406993295 0.520321755085951 445 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 59.801132462225 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Ala115fs Rv1258c_p.Ala115fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1377 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1131 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 1 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Ala135Thr Rv1258c_p.Ala135Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Ala148Thr Rv1258c_p.Ala148Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1378 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1132 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 3 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Ala166Thr Rv1258c_p.Ala166Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1404 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Ala178Val Rv1258c_p.Ala178Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 1 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Ala19Thr Rv1258c_p.Ala19Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1370 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Ala237Gly Rv1258c_p.Ala237Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Ala237Val Rv1258c_p.Ala237Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 8 9 10360 15599 0.000771604938271604 0.00033318123262376 0.00151980017311994 0.99942337262942 0.998905665124108 0.999736296428239 0.470588235294117 0.22983268726599 0.721881699668893 0 0 0.707598226178713 0 0 0.336267116879942 0 0 3.64440641898273 0.280548171103787 268 2512 False False 1.33839553839553 0.4491650409962 3.90961581926945 0 0 0.000356006060176228 0.99942337262942 0.998905665124108 0.999736296428239 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 8 8 7728 11866 0.00103412616339193 0.000446564649135067 0.00203661849802302 0.999326259053394 0.998672895689377 0.999709083033384 0.5 0.246510111490575 0.753489888509424 0 0 0.841886116991581 0 0 0.369416647552819 0 0 8.17706937988922 0.522292622794691 465 2071 False False 0 0 0 0 0 0 0 1.53545548654244 0.502105329260137 4.69542720874821 0 0 0.000477225565514406 0.999326259053394 0.998672895689377 0.999709083033384 6 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Ala275Val Rv1258c_p.Ala275Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.6429945931141 0.280491932584249 243 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 2 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Ala294Ser Rv1258c_p.Ala294Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Ala294Val Rv1258c_p.Ala294Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Ala29Glu Rv1258c_p.Ala29Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 23 0 10345 15608 0.00221836419753086 0.00140675621922997 0.00332678737658432 1 0.99976368249849 1 1 0.851814871084775 1 1 0.025 1 1 0.025 1 Inf 0.0386818784489005 Inf 0.39862834245203 291 2512 False False Inf 8.66950840569633 Inf 9.66557123526e-05 2.44710777175477e-06 0.000538412194144555 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 23 0 7713 11874 0.0029731127197518 0.0018856032714534 0.00445780906880445 1 0.999689379610589 1 1 0.851814871084775 1 1 0.025 1 1 0.025 1 Inf 0.0394684699896036 Inf 0.393812538288748 220 2071 False False 0 0 0 0 0 0 0 Inf 8.84585778141697 Inf 0.000129634430904848 3.28205424384983e-06 0.000722062830609886 1 0.999689379610589 1 3 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Ala29Val Rv1258c_p.Ala29Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 58.6540000158548 1 973.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 59.801132462225 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Ala319Glu Rv1258c_p.Ala319Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Ala341dup Rv1258c_p.Ala341dup 1 inframe_insertion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Ala367Gly Rv1258c_p.Ala367Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1389 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1140 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Ala367Thr Rv1258c_p.Ala367Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 10 0 10 0 12 10368 15596 0 0 0.000355731413006942 0.999231163505894 0.998657382918185 0.999602669866138 0 0 0.264648469397051 0 0 0.30849710781876 0 0 0.264648469397051 0 0 0.671273699771388 0.00776945288811197 60.5 2512 False False 0 0 0.541504747593943 0 0 0.000355731413006942 0.999231163505894 0.998657382918185 0.999602669866138 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 0 12 7736 11862 0 0 0.000476732171726368 0.998989388580091 0.998235331388827 0.999477696754876 0 0 0.264648469397051 0 0 0.30849710781876 0 0 0.264648469397051 0 0 0.684325887257874 0.00810087547783349 52 2071 False False 0 0 0 0 0 0 0 0 0 0.552062026148079 0 0 0.000476732171726368 0.998989388580091 0.998235331388827 0.999477696754876 42 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Ala373Val Rv1258c_p.Ala373Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.6429945931141 0.280491932584249 243 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.71438150990605 0.283358886007265 193.5 2071 False False 0 0 0 0 0 0 0 0 0 3.71438150990605 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Ala374Pro Rv1258c_p.Ala374Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 11 0 11 2 11 10366 15597 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999295233213736 0.998739328260189 0.999648132128855 0.153846153846153 0.0192066719825284 0.454471055676557 0 0 0.284914152918154 0 0 0.284914152918154 0 0 0.599672627146431 0.00440047298753921 56 2512 False False 0.273569185975128 0.0294615289970011 1.25390948755432 0 0 0.000355800035063835 0.999295233213736 0.998739328260189 0.999648132128855 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 2 10 7734 11864 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999157823816742 0.998451755191613 0.9995960722577 0.166666666666666 0.0208625254600923 0.484137748685967 0 0 0.30849710781876 0 0 0.30849710781876 0 0 0.684618243336882 0.00810877140395229 55 2071 False False 0 0 0 0 0 0 0 0.306801137832945 0.0326749863301206 1.44030192974163 0 0 0.000476855424503066 0.999157823816742 0.998451755191613 0.9995960722577 47 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Ala374Thr Rv1258c_p.Ala374Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Ala394Thr Rv1258c_p.Ala394Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 58.6540000158548 1 973.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1113 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Ala399Val Rv1258c_p.Ala399Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 6 11 10362 15597 0.000578703703703703 0.000212402724453782 0.00125916554902567 0.999295233213736 0.998739328260189 0.999648132128855 0.352941176470588 0.14209748311022 0.616716336556597 0 0 0.4592581264399 0 0 0.284914152918154 0 0 1.27871164449291 0.0875889090429278 129 2512 False False 0.821024372269305 0.249233335641071 2.42287371216559 0 0 0.000355937358633142 0.999295233213736 0.998739328260189 0.999648132128855 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 4 9 7732 11865 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.999242041435068 0.998561648359028 0.999653356368186 0.307692307692307 0.0909203945720966 0.614261661750705 0 0 0.602364635616474 0 0 0.336267116879942 0 0 2.32535348852449 0.158619812972559 148 2071 False False 0 0 0 0 0 0 0 0.682014140369029 0.153421017946502 2.44469827824845 0 0 0.000476978741026985 0.999242041435068 0.998561648359028 0.999653356368186 10 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Ala418Ser Rv1258c_p.Ala418Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1344 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1103 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Ala41Gly Rv1258c_p.Ala41Gly 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1345 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Ala58Ser Rv1258c_p.Ala58Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1390 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Ala65Thr Rv1258c_p.Ala65Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1394 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1145 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 5 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Ala78Thr Rv1258c_p.Ala78Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Arg141Leu Rv1258c_p.Arg141Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1355 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1111 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Arg217_Thr252delinsPro Rv1258c_p.Arg217_Thr252delinsPro 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Arg223Trp Rv1258c_p.Arg223Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1351 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1108 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Arg345Cys Rv1258c_p.Arg345Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 58.6634076928655 1 973.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 3 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Arg347Gln Rv1258c_p.Arg347Gln 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Arg396Trp Rv1258c_p.Arg396Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Arg6Cys Rv1258c_p.Arg6Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Asn151Lys Rv1258c_p.Asn151Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Asn5fs Rv1258c_p.Asn5fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1408 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1156 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 2 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Asp125Glu Rv1258c_p.Asp125Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Asp232Glu Rv1258c_p.Asp232Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 7 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Asp23Gly Rv1258c_p.Asp23Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1409 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1157 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 1 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Asp23Val Rv1258c_p.Asp23Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 7 0 7 2 8 10366 15600 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999487442337262 0.998990308225149 0.99977868883794 0.2 0.0252107263268333 0.556095462307641 0 0 0.409616397225003 0 0 0.369416647552819 0 0 1.04440445031152 0.0468708382497382 100 2512 False False 0.376229982635539 0.0389158944356182 1.88584091729022 0 0 0.000355800035063835 0.999487442337262 0.998990308225149 0.99977868883794 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 2 7 7734 11867 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999410476671719 0.998785736251934 0.999762949244471 0.222222222222222 0.0281449734778982 0.600093573716312 0 0 0.4592581264399 0 0 0.409616397225003 0 0 1.30360923019165 0.0877198263112506 110 2071 False False 0 0 0 0 0 0 0 0.438398167645646 0.044427948910893 2.30343996509364 0 0 0.000476855424503066 0.999410476671719 0.998785736251934 0.999762949244471 29 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Asp404Asn Rv1258c_p.Asp404Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1363 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Asp67Asn Rv1258c_p.Asp67Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 58.6502452744631 1 973.5 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 59.7961004349848 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 3.71438150990605 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 1 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Asp99Glu Rv1258c_p.Asp99Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Gln259Leu Rv1258c_p.Gln259Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 4 1 10364 15607 0.000385802469135802 0.000105127872737001 0.000987510251175401 0.999935930292158 0.99964307871082 0.999998377896754 0.8 0.28358206388191 0.994949236620532 NA NA NA 0 0 0.975 NA NA NA NA 1410 2512 False False 6.02354303357776 0.595936886271208 296.214625622934 0 0 0.000355868683600791 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Gln329* Rv1258c_p.Gln329* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Gln337Pro Rv1258c_p.Gln337Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 58.6540000158548 1 973.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1141 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Gln419Arg Rv1258c_p.Gln419Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 10 10368 15598 0 0 0.000355731413006942 0.999359302921578 0.998822051949738 0.999692719453314 0 0 0.30849710781876 0 0 0.975 0 0 0.30849710781876 0 0 58.6239620723747 1 973.5 2512 False False 0 0 0.671359765315085 0 0 0.000355731413006942 0.999359302921578 0.998822051949738 0.999692719453314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 7 7736 11867 0 0 0.000476732171726368 0.999410476671719 0.998785736251934 0.999762949244471 0 0 0.409616397225003 0 0 0.975 0 0 0.409616397225003 0 0 59.7759723181037 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 1.06467742986826 0 0 0.000476732171726368 0.999410476671719 0.998785736251934 0.999762949244471 3 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Gln43His Rv1258c_p.Gln43His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Glu130fs Rv1258c_p.Glu130fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Glu194Asp Rv1258c_p.Glu194Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Glu194fs Rv1258c_p.Glu194fs 1 frameshift (see "Genomic_coordinates" sheet) 1 5 1 4 5120 3296 5248 12312 0.493827160493827 0.484158207681728 0.503499582075282 0.788826242952332 0.782337644619278 0.795207023515171 0.608365019011406 0.597841137362901 0.618813817062714 0.2 0.00505076337946806 0.716417936118089 0.000303306035790112 7.67901449082751e-06 0.0016887419125741 0.586509146341463 0.0119113627850847 5.92906219551033 1 973.5 2512 False True 3.64432867629647 3.44998062640893 3.84928429504739 0.000190512478567346 4.82334671860502e-06 0.00106100546215945 0.788826242952332 0.782337644619278 0.795207023515171 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 1 5 1 4 4033 2467 3703 9407 0.521328852119958 0.510126169889639 0.532515455008916 0.792235135590365 0.784824498117672 0.799502237232416 0.620461538461538 0.608535543873448 0.632279354155498 0.2 0.00505076337946806 0.716417936118089 0.000405186385737439 1.02583784944243e-05 0.00225546424783382 0.635093167701863 0.0128966444288917 6.42120213955972 1 806.5 2071 False True 0 1 1 0 0 0 0 4.15294810756646 3.89787340109717 4.42493226632359 0.000269978401727861 6.83523797450594e-06 0.00150329541591978 0.792235135590365 0.784824498117672 0.799502237232416 6936 5) Not assoc w R New NotAwR yes 5 +Streptomycin Rv1258c p.Glu214Asp Rv1258c_p.Glu214Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Glu214Lys Rv1258c_p.Glu214Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1374 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1128 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Glu243Ala Rv1258c_p.Glu243Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 8 10368 15600 0 0 0.000355731413006942 0.999487442337262 0.998990308225149 0.99977868883794 0 0 0.369416647552819 0 0 0.975 0 0 0.369416647552819 0 0 58.6314715608905 1 973.5 2512 False False 0 0 0.881730950187969 0 0 0.000355731413006942 0.999487442337262 0.998990308225149 0.99977868883794 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 7 7736 11867 0 0 0.000476732171726368 0.999410476671719 0.998785736251934 0.999762949244471 0 0 0.409616397225003 0 0 0.975 0 0 0.409616397225003 0 0 59.7759723181037 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 1.06467742986826 0 0 0.000476732171726368 0.999410476671719 0.998785736251934 0.999762949244471 50 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Glu38fs Rv1258c_p.Glu38fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Glu38Lys Rv1258c_p.Glu38Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1341 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1101 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Gly161Ser Rv1258c_p.Gly161Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1401 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1152 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 2 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Gly195Asp Rv1258c_p.Gly195Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 5 0 10363 15608 0.000482253086419753 0.000156604214122162 0.00112505595550109 1 0.99976368249849 1 1 0.478176249895018 1 1 0.025 1 1 0.025 1 Inf 0.0386146956471901 Inf 0.39904512551979 294 2512 False False Inf 1.37979907306709 Inf 9.6487842531841e-05 2.44285768625785e-06 0.000537477296220785 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 4 0 7732 11874 0.000517063081695967 0.000140899683864147 0.00132335286075948 1 0.999689379610589 1 1 0.397635364383525 1 1 0.025 1 1 0.025 1 Inf 0.0393714946924981 Inf 0.394399959198245 222.5 2071 False False 0 0 0 0 0 0 0 Inf 1.01342344657205 Inf 0.000129315918789603 3.27399024170944e-06 0.000720289244853199 1 0.999689379610589 1 1 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Gly207Arg Rv1258c_p.Gly207Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1371 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1125 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Gly211Arg Rv1258c_p.Gly211Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Gly215Ala Rv1258c_p.Gly215Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1375 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1129 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Gly229Arg Rv1258c_p.Gly229Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1372 2512 False False Inf 0.282736080598822 Inf 0 0 0.000355800035063835 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1126 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0 0 0.000476855424503066 1 0.999689379610589 1 NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Gly24Asp Rv1258c_p.Gly24Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1383 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1135 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Gly24Cys Rv1258c_p.Gly24Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 1 4 10367 15604 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999743721168631 0.999343955596995 0.999930168370675 0.2 0.00505076337946806 0.716417936118089 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.28066788567474 0.155711983833633 162 2512 False False 0.376290151442075 0.00764455959995544 3.80334957923739 0 0 0.000355765720726338 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17379939830658 0.52225229054203 453 2071 False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 0 0 0.000476793790149404 0.999831564763348 0.99939168785815 0.999979601060482 24 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Gly271del Rv1258c_p.Gly271del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Gly277Ala Rv1258c_p.Gly277Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1405 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1154 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Gly277Arg Rv1258c_p.Gly277Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Gly322Arg Rv1258c_p.Gly322Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Gly360Arg Rv1258c_p.Gly360Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Gly360Asp Rv1258c_p.Gly360Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Gly360Ser Rv1258c_p.Gly360Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Gly363Val Rv1258c_p.Gly363Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 56 10367 15552 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.99641209636084 0.995343305615182 0.997288632330787 0.0175438596491228 0.000444073440089392 0.0939168418919107 NA NA NA 0 0 0.0637500966623622 NA NA NA NA 1356 2512 False True 0.0267882980335956 0.000671007721487855 0.155560629782646 0 0 0.000355765720726338 0.99641209636084 0.995343305615182 0.997288632330787 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 1 38 7735 11836 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.996799730503621 0.995609999809685 0.997734333730646 0.0256410256410256 0.000648963895481945 0.134763921559497 NA NA NA 0 0 0.0925127614158782 NA NA NA NA 1112 2071 False True 0 1 1 0 0 0 0 0.0402680910420848 0.000997963303935117 0.238448000536674 0 0 0.000476793790149404 0.996799730503621 0.995609999809685 0.997734333730646 28 5) Not assoc w R UP from Uncertain to NotAwR yes 4 +Streptomycin Rv1258c p.Gly375Arg Rv1258c_p.Gly375Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Gly391Arg Rv1258c_p.Gly391Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 3 10367 15605 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999807790876473 0.99943838714673 0.999960360103688 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1384 2512 False False 0.501752355229735 0.00956153582768186 6.25014259670444 0 0 0.000355765720726338 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1136 2071 False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 0 0 0.000476793790149404 0.999831564763348 0.99939168785815 0.999979601060482 5 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Gly42fs Rv1258c_p.Gly42fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 3 10367 15605 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999807790876473 0.99943838714673 0.999960360103688 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1346 2512 False False 0.501752355229735 0.00956153582768186 6.25014259670444 0 0 0.000355765720726338 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1104 2071 False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 0 0 0.000476793790149404 0.999831564763348 0.99939168785815 0.999979601060482 2 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Gly70Arg Rv1258c_p.Gly70Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1347 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Gly7Ser Rv1258c_p.Gly7Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1348 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1105 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Gly88fs Rv1258c_p.Gly88fs 1 frameshift (see "Genomic_coordinates" sheet) 1 25 0 25 13 29 10355 15579 0.00125385802469135 0.000667790166179422 0.00214318097672708 0.998141978472578 0.997332652594423 0.998755311644571 0.309523809523809 0.176221082641955 0.470860628932116 0 0 0.137185171530712 0 0 0.119444869069502 0 0 0.239287054912512 3.84642096689711e-06 27 2512 True False 0.67442681363326 0.321681738647991 1.33955710192262 0 0 0.000356177930119202 0.998141978472578 0.997332652594423 0.998755311644571 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 21 0 21 11 25 7725 11849 0.0014219234746639 0.000710026047388019 0.00254278626393864 0.997894559541856 0.99689351287282 0.998637020857779 0.305555555555555 0.163473984628493 0.481070630000079 0 0 0.161097615219079 0 0 0.137185171530712 0 0 0.294677383011998 4.38237064384197e-05 30 2071 True False 0 0 0 0 0 0 0 0.674894498381877 0.299579625155015 1.42295530392111 0 0 0.000477410851584718 0.997894559541856 0.99689351287282 0.998637020857779 42 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Gly95Arg Rv1258c_p.Gly95Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1373 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1127 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Gly95Glu Rv1258c_p.Gly95Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1392 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1143 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Gly97Asp Rv1258c_p.Gly97Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Gly98del Rv1258c_p.Gly98del 1 inframe_deletion (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1368 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1123 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.His254Arg Rv1258c_p.His254Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1382 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1134 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Ile12Val Rv1258c_p.Ile12Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1395 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1146 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Ile185Thr Rv1258c_p.Ile185Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Ile188fs Rv1258c_p.Ile188fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Ile27Val Rv1258c_p.Ile27Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1396 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1147 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Ile283Val Rv1258c_p.Ile283Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 10368 15604 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.28044779470556 0.155697794255122 153.5 2512 False False 0 0 2.28044779470556 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Ile411Val Rv1258c_p.Ile411Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1366 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1121 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Leu128Arg Rv1258c_p.Leu128Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Leu13Arg Rv1258c_p.Leu13Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Leu150Phe Rv1258c_p.Leu150Phe 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1412 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1158 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 1 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Leu183fs Rv1258c_p.Leu183fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Leu193Pro Rv1258c_p.Leu193Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1337 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1097 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Leu240Arg Rv1258c_p.Leu240Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 30 0 30 0 33 10368 15575 0 0 0.000355731413006942 0.997885699641209 0.997032005789816 0.998544179730394 0 0 0.105762810074579 0 0 0.115703308222027 0 0 0.105762810074579 0 0 0.196642012456332 3.93812518800489e-07 22 2512 True False 0 0 0.177727057459572 0 0 0.000355731413006942 0.997885699641209 0.997032005789816 0.998544179730394 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 14 0 14 0 17 7736 11857 0 0 0.000476732171726368 0.998568300488462 0.997708696799157 0.999165768038889 0 0 0.195064322969093 0 0 0.231635761650116 0 0 0.195064322969093 0 0 0.462251093883729 0.0014090439460666 38 2071 False False 0 0 0 0 0 0 0 0 0 0.371570349435616 0 0 0.000476732171726368 0.998568300488462 0.997708696799157 0.999165768038889 5 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Leu240Pro Rv1258c_p.Leu240Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Leu296Val Rv1258c_p.Leu296Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Leu300fs Rv1258c_p.Leu300fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1361 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Leu355Pro Rv1258c_p.Leu355Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1352 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1109 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Leu35Ser Rv1258c_p.Leu35Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Leu365Ser Rv1258c_p.Leu365Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Leu370Pro Rv1258c_p.Leu370Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1367 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1122 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Leu376fs Rv1258c_p.Leu376fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1406 2512 False False Inf 0.282736080598822 Inf 0 0 0.000355800035063835 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 7 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Leu381fs Rv1258c_p.Leu381fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Leu397Pro Rv1258c_p.Leu397Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Leu60Val Rv1258c_p.Leu60Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1413 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Lys198_Pro205delinsThr Rv1258c_p.Lys198_Pro205delinsThr 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Lys249fs Rv1258c_p.Lys249fs 1 frameshift (see "Genomic_coordinates" sheet) 1 10 1 9 2 9 10366 15599 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.99942337262942 0.998905665124108 0.999736296428239 0.181818181818181 0.0228311982999596 0.517755852360172 0.1 0.00252857854446178 0.445016117028195 0.1 0.00252857854446178 0.445016117028195 0.167202606812871 0.00381853295930294 1.20704637230824 0.0589588827478455 107 2512 False False 0.334405213625742 0.0351449615056338 1.61615001031672 9.64599209028648e-05 2.44215077354346e-06 0.000537321795461189 0.99942337262942 0.998905665124108 0.999736296428239 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 1 7 2 7 7734 11867 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999410476671719 0.998785736251934 0.999762949244471 0.222222222222222 0.0281449734778982 0.600093573716312 0.125 0.0031597235312519 0.526509670875206 0.125 0.0031597235312519 0.526509670875206 0.219199083822823 0.00486720916697249 1.70683213117425 0.158666048756797 152 2071 False False 0 0 0 0 0 0 0 0.438398167645646 0.044427948910893 2.30343996509364 0.000129282482223658 3.27314370392442e-06 0.000720103058325324 0.999410476671719 0.998785736251934 0.999762949244471 1 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Met121Val Rv1258c_p.Met121Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1411 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Met18Thr Rv1258c_p.Met18Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1338 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1098 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Met230Val Rv1258c_p.Met230Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Met242fs Rv1258c_p.Met242fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 3 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Met242Thr Rv1258c_p.Met242Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Met315Ile Rv1258c_p.Met315Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Met352Ile Rv1258c_p.Met352Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1349 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1106 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Met52Ile Rv1258c_p.Met52Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Met76Val Rv1258c_p.Met76Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1362 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1118 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Phe154Val Rv1258c_p.Phe154Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Phe251fs Rv1258c_p.Phe251fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1342 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1102 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Pro118Gln Rv1258c_p.Pro118Gln 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1397 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1148 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 2 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Pro129Arg Rv1258c_p.Pro129Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 10368 15604 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.28044779470556 0.155697794255122 153.5 2512 False False 0 0 2.28044779470556 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 7736 11870 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.32513012450998 0.158605093840654 142 2071 False False 0 0 0 0 0 0 0 0 0 2.32513012450998 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 2 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Pro129His Rv1258c_p.Pro129His 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1376 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1130 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Pro199fs Rv1258c_p.Pro199fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1350 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1107 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Pro241Leu Rv1258c_p.Pro241Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Pro241Ser Rv1258c_p.Pro241Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1343 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Pro257Leu Rv1258c_p.Pro257Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.6429945931141 0.280491932584249 243 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Pro312Ser Rv1258c_p.Pro312Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Pro361Leu Rv1258c_p.Pro361Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1398 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1149 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Pro361Ser Rv1258c_p.Pro361Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Pro369Thr Rv1258c_p.Pro369Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.50544998553101 0.0191837380556942 118.074698097101 1 973.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.53497091144149 0.0195519049186736 120.390152361053 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 15 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Pro398Ala Rv1258c_p.Pro398Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 0 10365 15608 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 1 0.99976368249849 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1360 2512 False False Inf 0.622129167636411 Inf 0 0 0.000355834356021348 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 7733 11874 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 1 0.999689379610589 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1117 2071 False False 0 0 0 0 0 0 0 Inf 0.634338273987677 Inf 0 0 0.000476917074793532 1 0.999689379610589 1 3 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Pro414Ser Rv1258c_p.Pro414Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 60 1 59 13 76 10355 15532 0.00125385802469135 0.000667790166179422 0.00214318097672708 0.995130702203998 0.993909084633025 0.996161685894681 0.146067415730337 0.0801310169341978 0.236820243635914 0.0166666666666666 0.000421874452342009 0.089399050057487 0.0129870129870129 0.000328748651410606 0.0702470606475967 0.0254229104092839 0.000637629324052183 0.147336727232023 2.81896915610843e-12 10 2512 True False 0.256570687946326 0.130594160898731 0.465763643274983 9.65623792970258e-05 2.44474478915486e-06 0.000537892405271169 0.995130702203998 0.993909084633025 0.996161685894681 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 42 1 41 6 51 7730 11823 0.00077559462254395 0.000284681048736677 0.00168737281383633 0.995704901465386 0.994356558863613 0.996800395058858 0.105263157894736 0.0396215358500808 0.215163604802103 0.0238095238095238 0.000602623301603574 0.125658557174992 0.0192307692307692 0.000486762415492083 0.102553544652117 0.0373047676142996 0.000926586149862484 0.21991876743599 2.59416758864694e-08 11 2071 True False 0 0 0 0 0 0 0 0.179940643786622 0.0630617081556983 0.419622620393736 0.000129349372655542 3.27483721749028e-06 0.000720475527685032 0.995704901465386 0.994356558863613 0.996800395058858 148 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Pro54Leu Rv1258c_p.Pro54Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Pro8Leu Rv1258c_p.Pro8Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 NA NA NA 0 0 0.707598226178713 NA NA NA NA 1385 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Pro90His Rv1258c_p.Pro90His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Pro90Leu Rv1258c_p.Pro90Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Ser184Pro Rv1258c_p.Ser184Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.01513406993295 0.520321755085951 445 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.17205443383047 0.522230766108178 361 2071 False False 0 0 0 0 0 0 0 0 0 3.71438150990605 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 2 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Ser292Leu Rv1258c_p.Ser292Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1386 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1137 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 6 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Ser40Asn Rv1258c_p.Ser40Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 1 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Ser417* Rv1258c_p.Ser417* 1 stop_gained (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Ser4Thr Rv1258c_p.Ser4Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 10368 15603 0 0 0.000355731413006942 0.999679651460789 0.999252573060182 0.999895975781355 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.64266120859479 0.164659119890409 198.5 2512 False False 0 0 1.64266120859479 0 0 0.000355731413006942 0.999679651460789 0.999252573060182 0.999895975781355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 7736 11869 0 0 0.000476732171726368 0.999578911908371 0.999017596768841 0.999863260157969 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.67480496260254 0.164218902979591 159.5 2071 False False 0 0 0 0 0 0 0 0 0 1.67480496260254 0 0 0.000476732171726368 0.999578911908371 0.999017596768841 0.999863260157969 1 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Ter420Glyext*? Rv1258c_p.Ter420Glyext*? 1 stop_lost (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Thr167Pro Rv1258c_p.Thr167Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Thr16Met Rv1258c_p.Thr16Met 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1400 2512 False False Inf 0.282736080598822 Inf 0 0 0.000355800035063835 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1151 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0 0 0.000476855424503066 1 0.999689379610589 1 NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Thr173fs Rv1258c_p.Thr173fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Thr173Ile Rv1258c_p.Thr173Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1407 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1155 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Thr173Pro Rv1258c_p.Thr173Pro 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 0 1 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 58.6634076928655 1 973.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 0 1 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 59.8138891519084 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Thr179fs Rv1258c_p.Thr179fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1399 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1150 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Thr202Ala Rv1258c_p.Thr202Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Thr290Ile Rv1258c_p.Thr290Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Thr297Ile Rv1258c_p.Thr297Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 58.6540000158548 1 973.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 59.801132462225 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 7 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Thr371Ile Rv1258c_p.Thr371Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1353 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Thr379Lys Rv1258c_p.Thr379Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Thr390Ser Rv1258c_p.Thr390Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Thr51Ala Rv1258c_p.Thr51Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Thr59Ala Rv1258c_p.Thr59Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Thr64Ser Rv1258c_p.Thr64Ser 1 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 5 10368 15603 0 0 0.000355731413006942 0.999679651460789 0.999252573060182 0.999895975781355 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 2.28030160110266 0.155688368476676 145 2512 False False 0 0 1.64266120859479 0 0 0.000355731413006942 0.999679651460789 0.999252573060182 0.999895975781355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 5 7736 11869 0 0 0.000476732171726368 0.999578911908371 0.999017596768841 0.999863260157969 0 0 0.521823750104981 0 0 0.602364635616474 0 0 0.521823750104981 0 0 2.32493416188502 0.158592168532284 136.5 2071 False False 0 0 0 0 0 0 0 0 0 1.67480496260254 0 0 0.000476732171726368 0.999578911908371 0.999017596768841 0.999863260157969 2 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Trp220Cys Rv1258c_p.Trp220Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Trp220* Rv1258c_p.Trp220* 1 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1391 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1142 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Trp262* Rv1258c_p.Trp262* 1 stop_gained (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1402 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1153 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 4 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Tyr250His Rv1258c_p.Tyr250His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Tyr325Cys Rv1258c_p.Tyr325Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Tyr332fs Rv1258c_p.Tyr332fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Tyr334Cys Rv1258c_p.Tyr334Cys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1359 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1116 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Tyr334His Rv1258c_p.Tyr334His 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Val156Asp Rv1258c_p.Val156Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Val219Ala Rv1258c_p.Val219Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 0 23 10368 15585 0 0 0.000355731413006942 0.998526396719631 0.997789687011067 0.999065639764335 0 0 0.148185128915224 0 0 0.369416647552819 0 0 0.148185128915224 0 0 0.880883714059145 0.0253506929584159 81 2512 False False 0 0 0.261582580255356 0 0 0.000355731413006942 0.998526396719631 0.997789687011067 0.999065639764335 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 21 7736 11853 0 0 0.000476732171726368 0.998231430015159 0.997297816737997 0.998904904364371 0 0 0.161097615219079 0 0 0.409616397225003 0 0 0.161097615219079 0 0 1.0634216269842 0.0472391289718305 78 2071 False False 0 0 0 0 0 0 0 0 0 0.294357607973833 0 0 0.000476732171726368 0.998231430015159 0.997297816737997 0.998904904364371 21 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Val224Ala Rv1258c_p.Val224Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1379 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 0 0 0.000355765720726338 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1133 2071 False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 0 0 0.000476793790149404 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Val245Met Rv1258c_p.Val245Met 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 17 0 10351 15608 0.00163966049382716 0.0009554436768022 0.00262396149717064 1 0.99976368249849 1 1 0.804935677030906 1 NA NA NA NA NA NA NA NA NA NA 1387 2512 False False Inf 6.21967292615542 Inf 0 0 0.000356315545602427 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1138 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Val25Ile Rv1258c_p.Val25Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Val280Leu Rv1258c_p.Val280Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 11 0 11 2 26 10366 15582 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.998334187596104 0.997560144791746 0.998911556433689 0.0714285714285714 0.00877049670352713 0.23503477317459 0 0 0.284914152918154 0 0 0.132274604497754 0 0 0.599097066037206 0.00438886075991788 55 2512 False False 0.115629498805265 0.013316597687008 0.462043773051012 0 0 0.000355800035063835 0.998334187596104 0.997560144791746 0.998911556433689 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 1 23 7735 11851 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.998062994778507 0.99709495013346 0.998771720922747 0.0416666666666666 0.00105435244546974 0.211201683456973 0 0 0.30849710781876 0 0 0.148185128915224 0 0 0.683779876753207 0.00808617678457669 51 2071 False False 0 0 0 0 0 0 0 0.0666142042101121 0.00162116655535533 0.410433459491758 0 0 0.000476793790149404 0.998062994778507 0.99709495013346 0.998771720922747 60 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Val285Ile Rv1258c_p.Val285Ile 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 3 1 10365 15607 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999935930292158 0.99964307871082 0.999998377896754 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 1364 2512 False False 4.51722141823444 0.362625225225282 236.854590713406 0 0 0.000355834356021348 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 1 7733 11873 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 0.999915782381674 0.999530859783396 0.999997867796783 0.75 0.194120449683243 0.99369053679029 NA NA NA 0 0 0.975 NA NA NA NA 1119 2071 False False 0 0 0 0 0 0 0 4.60610371136686 0.369734697559289 241.512824517625 0 0 0.000476917074793532 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Val304Ala Rv1258c_p.Val304Ala 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Val335Leu Rv1258c_p.Val335Leu 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1354 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1110 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 1 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Val335Met Rv1258c_p.Val335Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1339 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1099 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 3 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Val348Leu Rv1258c_p.Val348Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 3 10367 15605 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999807790876473 0.99943838714673 0.999960360103688 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.01590723734217 0.520331087227479 541.5 2512 False False 0.501752355229735 0.00956153582768186 6.25014259670444 0 0 0.000355765720726338 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 1 3 7735 11871 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999747347145022 0.999261820436506 0.999947893876346 0.25 0.00630946320970987 0.805879550316756 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.17311098997073 0.522243797058548 447.5 2071 False False 0 0 0 0 0 0 0 0.511570782159017 0.0097482170621519 6.37282132403124 0 0 0.000476793790149404 0.999747347145022 0.999261820436506 0.999947893876346 1 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Val349Ile Rv1258c_p.Val349Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv1258c p.Val388Met Rv1258c_p.Val388Met 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1380 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 16 3) Uncertain significance No change no 1 +Streptomycin Rv1258c p.Val66Ile Rv1258c_p.Val66Ile 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1357 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1114 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 3 3) Uncertain significance No change no 1 +Streptomycin Rv2477c c.1014G>A Rv2477c_c.1014G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.1030T>C Rv2477c_c.1030T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.50544998553101 0.0191837380556942 118.074698097101 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.1035C>T Rv2477c_c.1035C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 10365 15608 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 1 0.99976368249849 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.622129167636411 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.1038C>T Rv2477c_c.1038C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.1065C>T Rv2477c_c.1065C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.1068C>T Rv2477c_c.1068C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 5 1 10363 15607 0.000482253086419753 0.000156604214122162 0.00112505595550109 0.999935930292158 0.99964307871082 0.999998377896754 0.833333333333333 0.358765421002325 0.99578925548551 NA NA NA NA NA NA NA NA NA NA NA NA False False 7.53015536041686 0.842353453161053 355.554202953959 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 5 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.1071G>T Rv2477c_c.1071G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.1086A>G Rv2477c_c.1086A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 24 2 10344 15606 0.00231481481481481 0.00148369121109989 0.00344231557265305 0.999871860584315 0.999537193839207 0.999984481345552 0.923076923076923 0.748697083304626 0.990544608996287 NA NA NA NA NA NA NA NA NA NA NA NA False False 18.1044083526682 4.49321648189965 157.916233112883 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 23 2 7713 11872 0.0029731127197518 0.0018856032714534 0.00445780906880445 0.999831564763348 0.99939168785815 0.999979601060482 0.92 0.739694157894785 0.990160409981202 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 17.7010242447815 4.37129881309027 154.782023474924 NA NA NA NA NA NA 10 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.1098C>G Rv2477c_c.1098C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.1116A>G Rv2477c_c.1116A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 4 50 10364 15558 0.000385802469135802 0.000105127872737001 0.000987510251175401 0.996796514607893 0.995778758544176 0.997621404838553 0.074074074074074 0.0205509672980945 0.178933429166072 NA NA NA NA NA NA NA NA NA NA NA NA False True 0.12009262832883 0.0314658794713016 0.327291461010514 NA NA NA NA NA NA 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA NA NA NA 2 36 7734 11838 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.996968165740272 0.995805110243945 0.997875664594965 0.0526315789473684 0.00643871671509191 0.17749059034764 NA NA NA NA NA NA NA NA NA NA NA NA False True 0 1 1 0 0 0 0 0.0850357727782087 0.0099134000334643 0.330490245848048 NA NA NA NA NA NA 92 5) Not assoc w R Now listed Silent mutation no 0 +Streptomycin Rv2477c c.1122C>T Rv2477c_c.1122C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.1152C>G Rv2477c_c.1152C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.1155G>A Rv2477c_c.1155G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.17274275317631 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.1158G>A Rv2477c_c.1158G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.1164C>T Rv2477c_c.1164C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 0 10365 15608 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 1 0.99976368249849 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.622129167636411 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 3 0 7733 11874 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 1 0.999689379610589 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.634338273987677 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.1167G>A Rv2477c_c.1167G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.1167G>T Rv2477c_c.1167G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.1170C>T Rv2477c_c.1170C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.120C>T Rv2477c_c.120C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.1212G>A Rv2477c_c.1212G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.752676762805054 0.0127620362920002 14.460605698152 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.1215T>C Rv2477c_c.1215T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.1218C>A Rv2477c_c.1218C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.1269G>A Rv2477c_c.1269G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.1278G>A Rv2477c_c.1278G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.1323T>C Rv2477c_c.1323T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.1335C>T Rv2477c_c.1335C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.50544998553101 0.0191837380556942 118.074698097101 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.1344C>T Rv2477c_c.1344C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.1383C>A Rv2477c_c.1383C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.1387C>T Rv2477c_c.1387C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.1455G>A Rv2477c_c.1455G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.1473C>T Rv2477c_c.1473C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.1476C>T Rv2477c_c.1476C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.1497C>T Rv2477c_c.1497C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.1518C>T Rv2477c_c.1518C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.1521G>T Rv2477c_c.1521G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.1533G>A Rv2477c_c.1533G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.6429945931141 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.17274275317631 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.1545C>T Rv2477c_c.1545C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 449 1306 9919 14302 0.0433063271604938 0.0394688935478223 0.0474028399413813 0.916324961558175 0.911870840036841 0.920623188026602 0.255840455840455 0.235563506787144 0.2769368556199 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.495714985100601 0.442996088906031 0.55400769039747 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 251 993 7485 10881 0.0324457083764219 0.0286098079765358 0.0366389274326879 0.916371905002526 0.911247863077212 0.921290721641414 0.20176848874598 0.179790997252795 0.225164920561421 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.367452730233881 0.31766778429344 0.423840181020595 NA NA NA NA NA NA 4347 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.156C>G Rv2477c_c.156C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.1581C>T Rv2477c_c.1581C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.1587C>T Rv2477c_c.1587C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.17274275317631 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.1596C>T Rv2477c_c.1596C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.1620C>A Rv2477c_c.1620C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.1635T>A Rv2477c_c.1635T>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.165C>T Rv2477c_c.165C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 6 3 10362 15605 0.000578703703703703 0.000212402724453782 0.00125916554902567 0.999807790876473 0.99943838714673 0.999960360103688 0.666666666666666 0.29929505620854 0.925145368580308 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.01196680177571 0.64305389468782 18.6152161733465 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 6 1 7730 11873 0.00077559462254395 0.000284681048736677 0.00168737281383633 0.999915782381674 0.999530859783396 0.999997867796783 0.857142857142857 0.421276802956804 0.996389703138099 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 9.21578266494178 1.11767707530695 423.06722176879 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.1665G>T Rv2477c_c.1665G>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.-1927_-28del Rv2477c_c.-1927_-28del 2 upstream_gene_variant 2784069 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2446 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2020 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c c.204C>T Rv2477c_c.204C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.17274275317631 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.219G>A Rv2477c_c.219G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.-23G>A Rv2477c_c.-23G>A 2 upstream_gene_variant 2784065 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2504 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2067 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c c.252C>T Rv2477c_c.252C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.270A>G Rv2477c_c.270A>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.282736080598822 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.-29C>T Rv2477c_c.-29C>T 2 upstream_gene_variant 2784071 1 0 0 0 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2443 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 0 0 0.000355765720726338 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2018 2071 False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 0 0 0.000476793790149404 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c c.303C>T Rv2477c_c.303C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.17274275317631 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.309C>T Rv2477c_c.309C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.312C>T Rv2477c_c.312C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 3 5 10365 15603 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999679651460789 0.999252573060182 0.999895975781355 0.375 0.0852334141372535 0.755136783633448 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.903212735166425 0.140213309764784 4.64350502715881 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 5 7735 11869 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999578911908371 0.999017596768841 0.999863260157969 0.166666666666666 0.00421074451448947 0.641234578997674 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.306890756302521 0.00649200912492085 2.74344385104518 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.318C>T Rv2477c_c.318C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 18 10368 15590 0 0 0.000355731413006942 0.998846745258841 0.998177970363271 0.999316369446418 0 0 0.185301968137852 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.342114078747279 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 15 7736 11859 0 0 0.000476732171726368 0.998736735725113 0.997917292278642 0.999292793629768 0 0 0.218019360910534 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.427595288316977 NA NA NA NA NA NA 4 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.333C>T Rv2477c_c.333C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.-34G>A Rv2477c_c.-34G>A 2 upstream_gene_variant 2784076 NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2451 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2024 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c c.352C>T Rv2477c_c.352C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.393C>T Rv2477c_c.393C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 17 10366 15591 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.998910814966683 0.998256680139026 0.999365385605091 0.105263157894736 0.0130121643717774 0.331376664456765 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.176947259706506 0.0198305890590106 0.745709618775579 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 16 7734 11858 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.998652518106788 0.997812693726175 0.999229607694274 0.111111111111111 0.0137512156643644 0.347120438608672 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.191653736746832 0.0213743546169756 0.815595224999744 NA NA NA NA NA NA 11 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.417G>A Rv2477c_c.417G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.-41T>C Rv2477c_c.-41T>C 2 upstream_gene_variant 2784083 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c c.-43G>A Rv2477c_c.-43G>A 2 upstream_gene_variant 2784085 NA 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2421 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1999 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c c.453G>A Rv2477c_c.453G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.45C>T Rv2477c_c.45C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 1.50544998553101 0.0191837380556942 118.074698097101 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.468G>A Rv2477c_c.468G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.48C>T Rv2477c_c.48C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.498C>T Rv2477c_c.498C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.-4C>A Rv2477c_c.-4C>A 2 upstream_gene_variant 2784046 NA 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2485 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2050 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c c.51T>C Rv2477c_c.51T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.752676762805054 0.0127620362920002 14.460605698152 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.528C>T Rv2477c_c.528C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.538C>T Rv2477c_c.538C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.540G>A Rv2477c_c.540G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.541T>C Rv2477c_c.541T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 16 2 10352 15606 0.0015432098765432 0.000882326976774945 0.00250486960174422 0.999871860584315 0.999537193839207 0.999984481345552 0.888888888888888 0.652879561391328 0.986248784335635 NA NA NA NA NA NA NA NA NA NA NA NA False False 12.0602782071097 2.83430475177904 108.196879364932 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 5 0 7731 11874 0.000646328852119958 0.0002098934625097 0.00150766595359595 1 0.999689379610589 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.40693962335604 Inf NA NA NA NA NA NA 26 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.549C>A Rv2477c_c.549C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.-54T>C Rv2477c_c.-54T>C 2 upstream_gene_variant 2784096 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c c.588G>A Rv2477c_c.588G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.618C>T Rv2477c_c.618C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 3 10367 15605 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999807790876473 0.99943838714673 0.999960360103688 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0.501752355229735 0.00956153582768186 6.25014259670444 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 3 7735 11871 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999747347145022 0.999261820436506 0.999947893876346 0.25 0.00630946320970987 0.805879550316756 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0.511570782159017 0.0097482170621519 6.37282132403124 NA NA NA NA NA NA 9 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.627C>T Rv2477c_c.627C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.696C>T Rv2477c_c.696C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.699C>T Rv2477c_c.699C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.17274275317631 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.69C>T Rv2477c_c.69C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.708C>A Rv2477c_c.708C>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.708C>T Rv2477c_c.708C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 5 10368 15603 0 0 0.000355731413006942 0.999679651460789 0.999252573060182 0.999895975781355 0 0 0.521823750104981 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.64266120859479 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 4 7736 11870 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.32513012450998 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.729C>G Rv2477c_c.729C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.753G>A Rv2477c_c.753G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.762G>A Rv2477c_c.762G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.-78delG Rv2477c_c.-78delG 2 upstream_gene_variant 2784119 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 1 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c c.801C>T Rv2477c_c.801C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.813T>G Rv2477c_c.813T>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.-81G>A Rv2477c_c.-81G>A 2 upstream_gene_variant 2784123 1 3 0 3 0 6 10368 15602 0 0 0.000355731413006942 0.999615581752947 0.999163472525571 0.999858912630967 0 0 0.4592581264399 0 0 0.707598226178713 0 0 0.4592581264399 0 0 3.64229424819826 0.280464034820981 222 2512 False False 0 0 1.27838118563185 0 0 0.000355731413006942 0.999615581752947 0.999163472525571 0.999858912630967 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 5 7736 11869 0 0 0.000476732171726368 0.999578911908371 0.999017596768841 0.999863260157969 0 0 0.521823750104981 0 0 0.841886116991581 0 0 0.521823750104981 0 0 8.17067779513396 0.522213785907881 351.5 2071 False False 0 0 0 0 0 0 0 0 0 1.67480496260254 0 0 0.000476732171726368 0.999578911908371 0.999017596768841 0.999863260157969 23 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c c.81T>C Rv2477c_c.81T>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.282736080598822 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.-82A>G Rv2477c_c.-82A>G 2 upstream_gene_variant 2784124 NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2476 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2043 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c c.831C>G Rv2477c_c.831C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.831C>T Rv2477c_c.831C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 4 10368 15604 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.28044779470556 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.17274275317631 NA NA NA NA NA NA 3 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.-86G>A Rv2477c_c.-86G>A 2 upstream_gene_variant 2784128 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c c.870C>T Rv2477c_c.870C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.879G>A Rv2477c_c.879G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.-87G>C Rv2477c_c.-87G>C 2 upstream_gene_variant 2784129 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2505 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c c.-8A>G Rv2477c_c.-8A>G 2 upstream_gene_variant 2784050 1 6 0 6 1 6 10367 15602 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999615581752947 0.999163472525571 0.999858912630967 0.142857142857142 0.00361029686190058 0.578723197043195 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.27850451570591 0.0875884272338781 127.5 2512 False False 0.250827947654416 0.00545680578940276 2.0680301831463 0 0 0.000355765720726338 0.999615581752947 0.999163472525571 0.999858912630967 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 1 5 7735 11869 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999578911908371 0.999017596768841 0.999863260157969 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.67502148051906 0.164216700356639 156.5 2071 False False 0 0 0 0 0 0 0 0.306890756302521 0.00649200912492085 2.74344385104518 0 0 0.000476793790149404 0.999578911908371 0.999017596768841 0.999863260157969 29 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c c.900G>A Rv2477c_c.900G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.933C>T Rv2477c_c.933C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.948C>G Rv2477c_c.948C>G 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 34 17 10334 15591 0.00327932098765432 0.00227206172473011 0.00457953537856319 0.998910814966683 0.998256680139026 0.999365385605091 0.666666666666666 0.52078744576937 0.792416665086263 NA NA NA NA NA NA NA NA NA NA NA NA False False 3.01741823108186 1.63846335548552 5.76200828141416 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 34 17 7702 11857 0.00439503619441571 0.00304555303303915 0.00613625663203014 0.998568300488462 0.997708696799157 0.999165768038889 0.666666666666666 0.52078744576937 0.792416665086263 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 3.07894053492599 1.67159618317206 5.88161603388584 NA NA NA NA NA NA 58 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.960G>C Rv2477c_c.960G>C 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.96C>T Rv2477c_c.96C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.978C>T Rv2477c_c.978C>T 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c c.9G>A Rv2477c_c.9G>A 2 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 0 6 10368 15602 0 0 0.000355731413006942 0.999615581752947 0.999163472525571 0.999858912630967 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 1.27838118563185 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 0 6 7736 11868 0 0 0.000476732171726368 0.999494694290045 0.998900489118281 0.999814539856352 0 0 0.4592581264399 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 1.30338194607257 NA NA NA NA NA NA 6 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin Rv2477c LoF Rv2477c_LoF 2 LoF (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2512 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Ala139Thr Rv2477c_p.Ala139Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Ala260Arg Rv2477c_p.Ala260Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2486 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2051 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Ala277Thr Rv2477c_p.Ala277Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2473 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2040 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Ala277Val Rv2477c_p.Ala277Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2489 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2054 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Ala286Ser Rv2477c_p.Ala286Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Ala2Val Rv2477c_p.Ala2Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2487 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2052 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 5 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Ala335Thr Rv2477c_p.Ala335Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.6429945931141 0.280491932584249 243 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Ala392Val Rv2477c_p.Ala392Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.01513406993295 0.520321755085951 445 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.17205443383047 0.522230766108178 361 2071 False False 0 0 0 0 0 0 0 0 0 3.71438150990605 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Ala394Val Rv2477c_p.Ala394Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2452 2512 False False Inf 0.282736080598822 Inf 0 0 0.000355800035063835 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Ala424Val Rv2477c_p.Ala424Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 10368 15604 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 8.01462049278838 0.520315555582948 435.5 2512 False False 0 0 2.28044779470556 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 59.7961004349848 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 3.71438150990605 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 4 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Ala440Thr Rv2477c_p.Ala440Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 1 2 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.752676762805054 0.0127620362920002 14.460605698152 1 1332 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 1 2 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.333333333333333 0.00840375865961264 0.905700675949754 0.767420814479638 0.0130114906060525 14.7444541307454 1 806.5 2071 False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Ala454Val Rv2477c_p.Ala454Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2405 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1984 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Ala492Asp Rv2477c_p.Ala492Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2477 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Ala520Val Rv2477c_p.Ala520Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2456 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2027 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Ala52Thr Rv2477c_p.Ala52Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2434 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Ala531Pro Rv2477c_p.Ala531Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Ala531Thr Rv2477c_p.Ala531Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2453 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2025 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Ala62Thr Rv2477c_p.Ala62Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Ala65Val Rv2477c_p.Ala65Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 2 10365 15606 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999871860584315 0.999537193839207 0.999984481345552 0.6 0.146632799634673 0.947255049473683 0 0 0.975 0 0 0.841886116991581 0 0 58.6709610085939 1 973.5 2512 False False 2.25846599131693 0.258657968313028 27.0476864113414 0 0 0.000355834356021348 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 3 2 7733 11872 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 0.999831564763348 0.99939168785815 0.999979601060482 0.6 0.146632799634673 0.947255049473683 0 0 0.975 0 0 0.841886116991581 0 0 59.8243104913457 1 806.5 2071 False False 0 0 0 0 0 0 0 2.30285788180525 0.263724298106321 27.579548092527 0 0 0.000476917074793532 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Ala68Thr Rv2477c_p.Ala68Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2507 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Ala68Val Rv2477c_p.Ala68Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 2 3 10366 15605 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999807790876473 0.99943838714673 0.999960360103688 0.4 0.0527449505263169 0.853367200365326 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.01668055392903 0.520340422228443 552.5 2512 False False 1.00360151778249 0.0837840645585397 8.76371184924575 0 0 0.000355800035063835 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 2 3 7734 11871 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999747347145022 0.999261820436506 0.999947893876346 0.4 0.0527449505263169 0.853367200365326 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.1741678193458 0.52225683315318 459 2071 False False 0 0 0 0 0 0 0 1.02327385570209 0.0854221600622099 8.93608975066686 0 0 0.000476855424503066 0.999747347145022 0.999261820436506 0.999947893876346 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Arg231Leu Rv2477c_p.Arg231Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Arg233Cys Rv2477c_p.Arg233Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2428 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2006 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Arg251Pro Rv2477c_p.Arg251Pro 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2467 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2036 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Arg274Gln Rv2477c_p.Arg274Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Arg316His Rv2477c_p.Arg316His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2435 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2010 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Arg346Cys Rv2477c_p.Arg346Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 9 0 9 1 14 10367 15594 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.99910302409021 0.99849548434986 0.999509530910458 0.0666666666666666 0.0016864302413527 0.319484566578303 0 0 0.336267116879942 0 0 0.231635761650116 0 0 0.762256073524449 0.0139302998604435 73 2512 False False 0.107442571897091 0.00254496658115815 0.706417346749248 0 0 0.000355765720726338 0.99910302409021 0.99849548434986 0.999509530910458 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 9 0 9 1 13 7735 11861 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.998905170961765 0.998128536682641 0.999416924941029 0.0714285714285714 0.00180678065912538 0.338684489931821 0 0 0.336267116879942 0 0 0.24705263800047 0 0 0.777161520639527 0.0143450497619981 63 2071 False False 0 0 0 0 0 0 0 0.117955347819601 0.00277939727411228 0.785674707050631 0 0 0.000476793790149404 0.998905170961765 0.998128536682641 0.999416924941029 5 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Arg399Leu Rv2477c_p.Arg399Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2463 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Arg448His Rv2477c_p.Arg448His 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Arg450Lys Rv2477c_p.Arg450Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2411 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Arg450Ser Rv2477c_p.Arg450Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2423 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2001 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Arg450Thr Rv2477c_p.Arg450Thr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 12 1 10356 15607 0.0011574074074074 0.000598187780713703 0.00202088408121616 0.999935930292158 0.99964307871082 0.999998377896754 0.923076923076923 0.639702564732122 0.998054371502653 0 0 0.975 0 0 0.975 0 0 58.7256619770574 1 973.5 2512 False False 18.0845886442641 2.67495091962038 770.341315501115 0 0 0.000356143542856035 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Arg499Cys Rv2477c_p.Arg499Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2490 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2055 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Arg504Cys Rv2477c_p.Arg504Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Arg539Pro Rv2477c_p.Arg539Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Arg539Trp Rv2477c_p.Arg539Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Arg553His Rv2477c_p.Arg553His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Arg557Cys Rv2477c_p.Arg557Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2416 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1995 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Arg86Cys Rv2477c_p.Arg86Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2447 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2021 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Arg86His Rv2477c_p.Arg86His 2 missense_variant (see "Genomic_coordinates" sheet) 1 16 0 16 4 21 10364 15587 0.000385802469135802 0.000105127872737001 0.000987510251175401 0.998654536135315 0.997944046996364 0.999166949785744 0.16 0.0453794523717095 0.360828454459272 0 0 0.205907214207822 0 0 0.161097615219079 0 0 0.390073101371154 0.00041055352906291 42 2512 True False 0.286467809817867 0.0714966408096544 0.849395435643602 0 0 0.000355868683600791 0.998654536135315 0.997944046996364 0.999166949785744 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 14 0 14 4 19 7732 11855 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.99839986525181 0.997502314270442 0.999036348042965 0.17391304347826 0.0495076453057934 0.387811889954797 0 0 0.231635761650116 0 0 0.176466911806965 0 0 0.46241207242609 0.00140955524234141 39 2071 False False 0 0 0 0 0 0 0 0.322787050398889 0.0798464157296627 0.971812973072417 0 0 0.000476978741026985 0.99839986525181 0.997502314270442 0.999036348042965 70 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Asn240Ser Rv2477c_p.Asn240Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2432 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2008 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 1 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Asn535Ser Rv2477c_p.Asn535Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Asp101Glu Rv2477c_p.Asp101Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 1 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Asp133Tyr Rv2477c_p.Asp133Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Asp146Tyr Rv2477c_p.Asp146Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2412 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1990 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Asp17_Lys18insAsnAsp Rv2477c_p.Asp17_Lys18insAsnAsp 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Asp179Gly Rv2477c_p.Asp179Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Asp220Gly Rv2477c_p.Asp220Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0386035211949905 Inf 0.399114533205004 308.5 2512 False False Inf 0.282736080598822 Inf 9.64599209028648e-05 2.44215077354346e-06 0.000537321795461189 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0393613144801391 Inf 0.394461726758121 237.5 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0.000129282482223658 3.27314370392442e-06 0.000720103058325324 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Asp259Gly Rv2477c_p.Asp259Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01642086402598 0.520337288498982 548 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 0 0 0.000355765720726338 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Asp339Glu Rv2477c_p.Asp339Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 13 0 13 1 15 10367 15593 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999038954382368 0.998415396005541 0.999462013453075 0.0625 0.00158111172276588 0.302320738434531 0 0 0.24705263800047 0 0 0.218019360910534 0 0 0.49367016977866 0.00261253050116077 50 2512 False False 0.100273303109224 0.00238589753290877 0.651991272009026 0 0 0.000355765720726338 0.999038954382368 0.998415396005541 0.999462013453075 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 12 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Asp374Asn Rv2477c_p.Asp374Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 10 0 10 0 11 10368 15597 0 0 0.000355731413006942 0.999295233213736 0.998739328260189 0.999648132128855 0 0 0.284914152918154 0 0 0.30849710781876 0 0 0.284914152918154 0 0 0.671316732546192 0.00777048541956579 62 2512 False False 0 0 0.599557148974229 0 0 0.000355731413006942 0.999295233213736 0.998739328260189 0.999648132128855 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 10 0 10 0 11 7736 11863 0 0 0.000476732171726368 0.999073606198416 0.998343031567643 0.999537459717592 0 0 0.284914152918154 0 0 0.30849710781876 0 0 0.284914152918154 0 0 0.684383560543843 0.00810243186057899 53 2071 False False 0 0 0 0 0 0 0 0 0 0.611243759462621 0 0 0.000476732171726368 0.999073606198416 0.998343031567643 0.999537459717592 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Asp374Glu Rv2477c_p.Asp374Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2502 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2065 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Asp408Asn Rv2477c_p.Asp408Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Asp435Glu Rv2477c_p.Asp435Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2468 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Asp503Asn Rv2477c_p.Asp503Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Asp503Gly Rv2477c_p.Asp503Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Asp516His Rv2477c_p.Asp516His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2469 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2037 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Asp517_Asn518dup Rv2477c_p.Asp517_Asn518dup 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2406 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1985 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Asp517Ala Rv2477c_p.Asp517Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2413 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1991 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 3 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Asp517Asn Rv2477c_p.Asp517Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2495 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Asp543Tyr Rv2477c_p.Asp543Tyr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2429 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Asp55Ala Rv2477c_p.Asp55Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 58.6634076928655 1 973.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 59.8138891519084 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 5 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Asp82Gly Rv2477c_p.Asp82Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Asp95Gly Rv2477c_p.Asp95Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Gln196His Rv2477c_p.Gln196His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Gln263Glu Rv2477c_p.Gln263Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2470 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2038 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Gln281His Rv2477c_p.Gln281His 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2424 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2002 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Gln289Pro Rv2477c_p.Gln289Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Gln417His Rv2477c_p.Gln417His 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2436 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2011 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 1 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Gln74His Rv2477c_p.Gln74His 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.01513406993295 0.520321755085951 445 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.17205443383047 0.522230766108178 361 2071 False False 0 0 0 0 0 0 0 0 0 3.71438150990605 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 1 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Glu117Ala Rv2477c_p.Glu117Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2433 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2009 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Glu120Asp Rv2477c_p.Glu120Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Glu128Asp Rv2477c_p.Glu128Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2407 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1986 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Glu128Lys Rv2477c_p.Glu128Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2437 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2012 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Glu224Lys Rv2477c_p.Glu224Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 4 10368 15604 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 0 0 0.602364635616474 NA NA NA 0 0 0.602364635616474 NA NA NA NA 2496 2512 False False 0 0 2.28044779470556 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2059 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Glu250Ala Rv2477c_p.Glu250Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Glu268Lys Rv2477c_p.Glu268Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Glu293Asp Rv2477c_p.Glu293Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2408 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1987 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Glu323Ala Rv2477c_p.Glu323Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2482 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2047 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Glu323Leu Rv2477c_p.Glu323Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Glu404Asp Rv2477c_p.Glu404Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Glu447Ala Rv2477c_p.Glu447Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Glu476Ala Rv2477c_p.Glu476Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Glu476Lys Rv2477c_p.Glu476Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2417 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1996 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Glu513Ala Rv2477c_p.Glu513Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Glu513Lys Rv2477c_p.Glu513Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Glu519Asp Rv2477c_p.Glu519Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2508 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2069 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Glu519Lys Rv2477c_p.Glu519Lys 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 5 10368 15603 0 0 0.000355731413006942 0.999679651460789 0.999252573060182 0.999895975781355 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.64266120859479 0.164659119890409 198.5 2512 False False 0 0 1.64266120859479 0 0 0.000355731413006942 0.999679651460789 0.999252573060182 0.999895975781355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 5 7736 11869 0 0 0.000476732171726368 0.999578911908371 0.999017596768841 0.999863260157969 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.67480496260254 0.164218902979591 159.5 2071 False False 0 0 0 0 0 0 0 0 0 1.67480496260254 0 0 0.000476732171726368 0.999578911908371 0.999017596768841 0.999863260157969 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Glu90Asp Rv2477c_p.Glu90Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Glu91Asp Rv2477c_p.Glu91Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2448 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2022 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Gly162Ser Rv2477c_p.Gly162Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2503 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2066 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Gly207Cys Rv2477c_p.Gly207Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0385973247056878 Inf 0.399153031761308 409.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 1 0.025 1 0.5 0.012579117093425 0.987420882906574 Inf 0.0393529118200762 Inf 0.394512723749298 338.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Gly207Ser Rv2477c_p.Gly207Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Gly232Asp Rv2477c_p.Gly232Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 6 0 6 0 6 10368 15602 0 0 0.000355731413006942 0.999615581752947 0.999163472525571 0.999858912630967 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.27838118563185 0.0875881391169989 126 2512 False False 0 0 1.27838118563185 0 0 0.000355731413006942 0.999615581752947 0.999163472525571 0.999858912630967 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 6 7736 11868 0 0 0.000476732171726368 0.999494694290045 0.998900489118281 0.999814539856352 0 0 0.4592581264399 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.30338194607257 0.0877178102615035 109 2071 False False 0 0 0 0 0 0 0 0 0 1.30338194607257 0 0 0.000476732171726368 0.999494694290045 0.998900489118281 0.999814539856352 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Gly256Ser Rv2477c_p.Gly256Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Gly395Asp Rv2477c_p.Gly395Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 3 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Gly409Ser Rv2477c_p.Gly409Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2418 2512 False False Inf 0.282736080598822 Inf 0 0 0.000355800035063835 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1997 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0 0 0.000476855424503066 1 0.999689379610589 1 1 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Gly41Glu Rv2477c_p.Gly41Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 40 3 37 88 113 10280 15495 0.00848765432098765 0.00681275256809637 0.0104467161746282 0.992760123013839 0.991302052770112 0.994029701253405 0.437810945273631 0.368111918355904 0.509371746856262 0.075 0.0157421798510415 0.203864748732898 0.0258620689655172 0.00536546834604213 0.0737213051357635 0.122213166473866 0.0241303153457688 0.386154536580597 6.14269831846486e-06 29 2512 True False 1.17382321545401 0.87703749080894 1.56673334768792 0.000291743654575513 6.01685968337377e-05 0.00085235969909718 0.992760123013839 0.991302052770112 0.994029701253405 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 4 6 7732 11868 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.999494694290045 0.998900489118281 0.999814539856352 0.4 0.121552258119827 0.737621923393055 0 0 0.707598226178713 0 0 0.4592581264399 0 0 3.71536432205961 0.283398883821824 209 2071 False False 0 0 0 0 0 0 0 1.02327987584066 0.212320035147848 4.31668986259282 0 0 0.000476978741026985 0.999494694290045 0.998900489118281 0.999814539856352 190 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Gly433Val Rv2477c_p.Gly433Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2414 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1992 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Gly441Ala Rv2477c_p.Gly441Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 19 6 10349 15602 0.00183256172839506 0.00110367119743855 0.00286029933187508 0.999615581752947 0.999163472525571 0.999858912630967 0.76 0.548711982183313 0.906435560668257 0 0 0.975 0 0 0.4592581264399 0 0 58.7465390681144 1 973.5 2512 False False 4.77402003414178 1.83214091463835 14.6106449454493 0 0 0.000356384393229329 0.999615581752947 0.999163472525571 0.999858912630967 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 19 5 7717 11869 0.00245604963805584 0.00147932993205813 0.00383278019133476 0.999578911908371 0.999017596768841 0.999863260157969 0.791666666666666 0.578487156362747 0.928681382801945 NA NA NA 0 0 0.521823750104981 NA NA NA NA 1993 2071 False False 0 0 0 0 0 0 0 5.84452507451082 2.10949775685755 20.0334258410629 0 0 0.000477905651900639 0.999578911908371 0.999017596768841 0.999863260157969 9 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Gly445Ser Rv2477c_p.Gly445Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2491 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2056 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Gly460Ser Rv2477c_p.Gly460Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2499 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2062 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Gly527Ser Rv2477c_p.Gly527Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2409 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1988 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Gly530Asp Rv2477c_p.Gly530Asp 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Gly53Ser Rv2477c_p.Gly53Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Gly87Ser Rv2477c_p.Gly87Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2492 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Gly92Arg Rv2477c_p.Gly92Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.His189Tyr Rv2477c_p.His189Tyr 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 10 2 10358 15606 0.000964506172839506 0.000462612020337809 0.00177304351401163 0.999871860584315 0.999537193839207 0.999984481345552 0.833333333333333 0.515862251314033 0.979137474539907 0 0 0.975 0 0 0.841886116991581 0 0 58.7105748310785 1 973.5 2512 False False 7.53330758833751 1.60478662030748 70.8637470762236 0 0 0.000356074788245403 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 10 2 7726 11872 0.00129265770423991 0.000620048157733657 0.00237595446225449 0.999831564763348 0.99939168785815 0.999979601060482 0.833333333333333 0.515862251314033 0.979137474539907 0 0 0.975 0 0 0.841886116991581 0 0 59.8784624938899 1 806.5 2071 False False 0 0 0 0 0 0 0 7.68314781258089 1.63648923763142 71.9805522140955 0 0 0.000477349073576999 0.999831564763348 0.99939168785815 0.999979601060482 15 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.His548Arg Rv2477c_p.His548Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2509 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Ile20Val Rv2477c_p.Ile20Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 1 1 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.50544998553101 0.0191837380556942 118.074698097101 1 973.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 1 1 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.53497091144149 0.0195519049186736 120.390152361053 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Ile396Val Rv2477c_p.Ile396Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2483 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2048 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Ile413Val Rv2477c_p.Ile413Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Ile96Val Rv2477c_p.Ile96Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2457 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2028 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Leu109Phe Rv2477c_p.Leu109Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 3 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Leu137Val Rv2477c_p.Leu137Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2474 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2041 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Leu148Pro Rv2477c_p.Leu148Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Leu198Phe Rv2477c_p.Leu198Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Leu198Val Rv2477c_p.Leu198Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2458 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 2029 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Leu21Phe Rv2477c_p.Leu21Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Leu227Gln Rv2477c_p.Leu227Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 4 1 10364 15607 0.000385802469135802 0.000105127872737001 0.000987510251175401 0.999935930292158 0.99964307871082 0.999998377896754 0.8 0.28358206388191 0.994949236620532 NA NA NA 0 0 0.975 NA NA NA NA 2425 2512 False False 6.02354303357776 0.595936886271208 296.214625622934 0 0 0.000355868683600791 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 4 1 7732 11873 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.999915782381674 0.999530859783396 0.999997867796783 0.8 0.28358206388191 0.994949236620532 NA NA NA 0 0 0.975 NA NA NA NA 2003 2071 False False 0 0 0 0 0 0 0 6.14226590791515 0.607630898004113 302.048561734113 0 0 0.000476978741026985 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Leu245Met Rv2477c_p.Leu245Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2459 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2030 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Leu288Val Rv2477c_p.Leu288Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 10 0 10 11 10 10357 15598 0.00106095679012345 0.000529741017552837 0.00189754996565939 0.999359302921578 0.998822051949738 0.999692719453314 0.523809523809523 0.297806838783642 0.742869373593593 0 0 0.30849710781876 0 0 0.30849710781876 0 0 0.672072866362613 0.0077886941240312 63 2512 False False 1.65663802259341 0.638447587715896 4.35266794719847 0 0 0.000356109162232076 0.999359302921578 0.998822051949738 0.999692719453314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 7 6 7729 11868 0.000904860392967942 0.000363875741427306 0.00186346392020999 0.999494694290045 0.998900489118281 0.999814539856352 0.538461538461538 0.251345482270303 0.807767558198712 0 0 0.4592581264399 0 0 0.4592581264399 0 0 1.30456263840536 0.0877284449564672 111 2071 False False 0 0 0 0 0 0 0 1.79143485573812 0.515289863347351 6.45490518681499 0 0 0.000477163835447126 0.999494694290045 0.998900489118281 0.999814539856352 21 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Leu304Phe Rv2477c_p.Leu304Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Leu327His Rv2477c_p.Leu327His 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 2 10366 15606 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999871860584315 0.999537193839207 0.999984481345552 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 58.6653062545381 1 973.5 2512 False False 1.50549874590005 0.10909391082996 20.7696540777406 0 0 0.000355800035063835 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 2 7734 11872 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999831564763348 0.99939168785815 0.999979601060482 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 59.8165824855725 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53504008275148 0.111228967362952 21.1783159842378 0 0 0.000476855424503066 0.999831564763348 0.99939168785815 0.999979601060482 4 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Leu327Phe Rv2477c_p.Leu327Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 2 3 10366 15605 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999807790876473 0.99943838714673 0.999960360103688 0.4 0.0527449505263169 0.853367200365326 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.01668055392903 0.520340422228443 552.5 2512 False False 1.00360151778249 0.0837840645585397 8.76371184924575 0 0 0.000355800035063835 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 2 3 7734 11871 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999747347145022 0.999261820436506 0.999947893876346 0.4 0.0527449505263169 0.853367200365326 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.1741678193458 0.52225683315318 459 2071 False False 0 0 0 0 0 0 0 1.02327385570209 0.0854221600622099 8.93608975066686 0 0 0.000476855424503066 0.999747347145022 0.999261820436506 0.999947893876346 6 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Leu370Arg Rv2477c_p.Leu370Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 4 0 4 0 4 10368 15604 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.28044779470556 0.155697794255122 153.5 2512 False False 0 0 2.28044779470556 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 7736 11870 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.32513012450998 0.158605093840654 142 2071 False False 0 0 0 0 0 0 0 0 0 2.32513012450998 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 2 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Leu453Phe Rv2477c_p.Leu453Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2415 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1994 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Leu455Ser Rv2477c_p.Leu455Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2471 2512 False False Inf 0.282736080598822 Inf 0 0 0.000355800035063835 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2039 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0 0 0.000476855424503066 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Leu481Val Rv2477c_p.Leu481Val 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2472 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Leu486Arg Rv2477c_p.Leu486Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Leu486Pro Rv2477c_p.Leu486Pro 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Leu502Phe Rv2477c_p.Leu502Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Leu540Phe Rv2477c_p.Leu540Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 2 3 10366 15605 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999807790876473 0.99943838714673 0.999960360103688 0.4 0.0527449505263169 0.853367200365326 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.64369758531757 0.280519937201876 266.5 2512 False False 1.00360151778249 0.0837840645585397 8.76371184924575 0 0 0.000355800035063835 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 7734 11873 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999915782381674 0.999530859783396 0.999997867796783 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 59.821615810862 1 806.5 2071 False False 0 0 0 0 0 0 0 3.07033876389966 0.159799628612092 180.959738606129 0 0 0.000476855424503066 0.999915782381674 0.999530859783396 0.999997867796783 5 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Leu54Ser Rv2477c_p.Leu54Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2478 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2044 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Leu64Gln Rv2477c_p.Leu64Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Lys10Glu Rv2477c_p.Lys10Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Lys13Glu Rv2477c_p.Lys13Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Lys303Glu Rv2477c_p.Lys303Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2493 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2057 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 4 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Lys338Glu Rv2477c_p.Lys338Glu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2444 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2019 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Lys33Arg Rv2477c_p.Lys33Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2440 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2015 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Lys33Asn Rv2477c_p.Lys33Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 5 0 5 0 8 10368 15600 0 0 0.000355731413006942 0.999487442337262 0.998990308225149 0.99977868883794 0 0 0.369416647552819 0 0 0.521823750104981 0 0 0.369416647552819 0 0 1.64234544623359 0.164664307744258 203 2512 False False 0 0 0.881730950187969 0 0 0.000355731413006942 0.999487442337262 0.998990308225149 0.99977868883794 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 6 7736 11868 0 0 0.000476732171726368 0.999494694290045 0.998900489118281 0.999814539856352 0 0 0.4592581264399 0 0 0.602364635616474 0 0 0.4592581264399 0 0 2.32473819937431 0.158579244442435 134.5 2071 False False 0 0 0 0 0 0 0 0 0 1.30338194607257 0 0 0.000476732171726368 0.999494694290045 0.998900489118281 0.999814539856352 2 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Lys400Gln Rv2477c_p.Lys400Gln 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Lys458Asn Rv2477c_p.Lys458Asn 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2449 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Lys458Glu Rv2477c_p.Lys458Glu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Met122Val Rv2477c_p.Met122Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 30 0 30 0 34 10368 15574 0 0 0.000355731413006942 0.997821629933367 0.996957264071706 0.998490958165439 0 0 0.102817924259012 0 0 0.115703308222027 0 0 0.102817924259012 0 0 0.196629389565766 3.93788084592736e-07 21 2512 True False 0 0 0.172201910770567 0 0 0.000355731413006942 0.997821629933367 0.996957264071706 0.998490958165439 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 30 0 30 0 34 7736 11840 0 0 0.000476732171726368 0.997136600976924 0.996000964133285 0.998016222717729 0 0 0.102817924259012 0 0 0.115703308222027 0 0 0.102817924259012 0 0 0.200366134727773 4.11139462265346e-07 14 2071 True False 0 0 0 0 0 0 0 0 0 0.175474453044032 0 0 0.000476732171726368 0.997136600976924 0.996000964133285 0.998016222717729 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Met51Val Rv2477c_p.Met51Val 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Met93Ile Rv2477c_p.Met93Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.01513406993295 0.520321755085951 445 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.17205443383047 0.522230766108178 361 2071 False False 0 0 0 0 0 0 0 0 0 3.71438150990605 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Phe429Leu Rv2477c_p.Phe429Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Phe488Leu Rv2477c_p.Phe488Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2488 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2053 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Phe4Ser Rv2477c_p.Phe4Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 3 1 10365 15607 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999935930292158 0.99964307871082 0.999998377896754 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 58.6747168343076 1 610 2512 False False 4.51722141823444 0.362625225225282 236.854590713406 0 0 0.000355834356021348 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Pro186Ser Rv2477c_p.Pro186Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2464 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Pro206Ser Rv2477c_p.Pro206Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Pro355Ser Rv2477c_p.Pro355Ser 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2441 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2016 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Pro39Ser Rv2477c_p.Pro39Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 2 2 10366 15606 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999871860584315 0.999537193839207 0.999984481345552 0.5 0.067585986488543 0.932414013511457 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01719423016258 0.52034662480125 555 2512 False False 1.50549874590005 0.10909391082996 20.7696540777406 0 0 0.000355800035063835 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 2 2 7734 11872 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999831564763348 0.99939168785815 0.999979601060482 0.5 0.067585986488543 0.932414013511457 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17485631669468 0.52226532889017 461 2071 False False 0 0 0 0 0 0 0 1.53504008275148 0.111228967362952 21.1783159842378 0 0 0.000476855424503066 0.999831564763348 0.99939168785815 0.999979601060482 19 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Pro421Leu Rv2477c_p.Pro421Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2410 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1989 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Pro434Gln Rv2477c_p.Pro434Gln 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 3 0 10365 15608 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 1 0.99976368249849 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 2465 2512 False False Inf 0.622129167636411 Inf 0 0 0.000355834356021348 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2034 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0 0 0.000476855424503066 1 0.999689379610589 1 5 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Pro489Leu Rv2477c_p.Pro489Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2479 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Pro489Ser Rv2477c_p.Pro489Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2506 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2068 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Pro547Leu Rv2477c_p.Pro547Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Pro57Leu Rv2477c_p.Pro57Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Pro77Leu Rv2477c_p.Pro77Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Pro77Thr Rv2477c_p.Pro77Thr 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2500 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2063 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Pro78Ser Rv2477c_p.Pro78Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Ser176Ala Rv2477c_p.Ser176Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2445 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Ser27Gly Rv2477c_p.Ser27Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2501 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2064 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 7 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Ser341Ala Rv2477c_p.Ser341Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Ser341Trp Rv2477c_p.Ser341Trp 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.6429945931141 0.280491932584249 243 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.71438150990605 0.283358886007265 193.5 2071 False False 0 0 0 0 0 0 0 0 0 3.71438150990605 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Ser375Gly Rv2477c_p.Ser375Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2442 2512 False False Inf 0.282736080598822 Inf 0 0 0.000355800035063835 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2017 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0 0 0.000476855424503066 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Ser377Cys Rv2477c_p.Ser377Cys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2510 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2070 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Ser407Ala Rv2477c_p.Ser407Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Ser480Leu Rv2477c_p.Ser480Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2426 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2004 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Thr112Asn Rv2477c_p.Thr112Asn 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2419 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1998 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Thr267Ile Rv2477c_p.Thr267Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2497 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2060 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Thr362Ala Rv2477c_p.Thr362Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2484 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2049 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Thr372Lys Rv2477c_p.Thr372Lys 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 42 10368 15566 0 0 0.000355731413006942 0.99730907227063 0.996364369242586 0.998059948726648 0 0 0.0840838549403552 NA NA NA 0 0 0.0840838549403552 NA NA NA NA 2430 2512 False True 0 0 0.137863356429157 0 0 0.000355731413006942 0.99730907227063 0.996364369242586 0.998059948726648 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R NA 0 0 0 0 38 7736 11836 0 0 0.000476732171726368 0.996799730503621 0.995609999809685 0.997734333730646 0 0 0.0925127614158782 NA NA NA 0 0 0.0925127614158782 NA NA NA NA 2007 2071 False True 1 1 1 0 0 0 0 0 0 0.156046470965314 0 0 0.000476732171726368 0.996799730503621 0.995609999809685 0.997734333730646 39 5) Not assoc w R New NotAwR yes 5 +Streptomycin Rv2477c p.Thr418Ala Rv2477c_p.Thr418Ala 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2462 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2032 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Thr505Arg Rv2477c_p.Thr505Arg 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2498 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2061 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Thr505Met Rv2477c_p.Thr505Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2454 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Trp512Arg Rv2477c_p.Trp512Arg 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Trp512Ser Rv2477c_p.Trp512Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Tyr114Asp Rv2477c_p.Tyr114Asp 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2455 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2026 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Tyr114Cys Rv2477c_p.Tyr114Cys 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2466 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2035 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Tyr114Ser Rv2477c_p.Tyr114Ser 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Val195Met Rv2477c_p.Val195Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.6429945931141 0.280491932584249 243 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.71438150990605 0.283358886007265 193.5 2071 False False 0 0 0 0 0 0 0 0 0 3.71438150990605 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Val313Leu Rv2477c_p.Val313Leu 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2438 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2013 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Val313Phe Rv2477c_p.Val313Phe 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2460 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Val320Met Rv2477c_p.Val320Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 8 0 8 0 9 10368 15599 0 0 0.000355731413006942 0.99942337262942 0.998905665124108 0.999736296428239 0 0 0.336267116879942 0 0 0.369416647552819 0 0 0.336267116879942 0 0 0.881674467766685 0.0253699898029407 84 2512 False False 0 0 0.762426796904344 0 0 0.000355731413006942 0.99942337262942 0.998905665124108 0.999736296428239 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 0 6 7736 11868 0 0 0.000476732171726368 0.999494694290045 0.998900489118281 0.999814539856352 0 0 0.4592581264399 0 0 0.521823750104981 0 0 0.4592581264399 0 0 1.67466390164345 0.164220338004954 162.5 2071 False False 0 0 0 0 0 0 0 0 0 1.30338194607257 0 0 0.000476732171726368 0.999494694290045 0.998900489118281 0.999814539856352 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Val322Ile Rv2477c_p.Val322Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01642086402598 0.520337288498982 548 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 0 0 0.000355765720726338 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 59.8138891519084 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Val324Ala Rv2477c_p.Val324Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 1 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Val324Ile Rv2477c_p.Val324Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2475 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2042 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Val350Phe Rv2477c_p.Val350Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2439 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 2014 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Val358Ile Rv2477c_p.Val358Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Val368Phe Rv2477c_p.Val368Phe 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 2 1 10366 15607 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999935930292158 0.99964307871082 0.999998377896754 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 2480 2512 False False 3.01119043025274 0.156729426968348 177.474331043773 0 0 0.000355800035063835 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 2 1 7734 11873 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999915782381674 0.999530859783396 0.999997867796783 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 2045 2071 False False 0 0 0 0 0 0 0 3.07033876389966 0.159799628612092 180.959738606129 0 0 0.000476855424503066 0.999915782381674 0.999530859783396 0.999997867796783 5 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Val389_Asp390insGly Rv2477c_p.Val389_Asp390insGly 2 inframe_insertion (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2481 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2046 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Val389Ala Rv2477c_p.Val389Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Val389Met Rv2477c_p.Val389Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Val405Gly Rv2477c_p.Val405Gly 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2420 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 6 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Val426Ala Rv2477c_p.Val426Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 2 1 10366 15607 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999935930292158 0.99964307871082 0.999998377896754 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 58.6690617185945 1 973.5 2512 False False 3.01119043025274 0.156729426968348 177.474331043773 0 0 0.000355800035063835 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 2033 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0 0 0.000476855424503066 1 0.999689379610589 1 2 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Val426Met Rv2477c_p.Val426Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 7 0 10361 15608 0.000675154320987654 0.000271488767107418 0.00139057803317028 1 0.99976368249849 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 2494 2512 False False Inf 2.17055584412876 Inf 0 0 0.000355971706089883 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 7 0 7729 11874 0.000904860392967942 0.000363875741427306 0.00186346392020999 1 0.999689379610589 1 1 0.590383602774996 1 NA NA NA NA NA NA NA NA NA NA 2058 2071 False False 0 0 0 0 0 0 0 Inf 2.21347144138593 Inf 0 0 0.000477163835447126 1 0.999689379610589 1 3 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Val442Leu Rv2477c_p.Val442Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2461 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2031 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Val475Gly Rv2477c_p.Val475Gly 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Val493Met Rv2477c_p.Val493Met 2 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 58.6540000158548 1 973.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 59.801132462225 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 3 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Val550fs Rv2477c_p.Val550fs 2 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2431 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Val550Leu Rv2477c_p.Val550Leu 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2450 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 2023 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Val70Ala Rv2477c_p.Val70Ala 2 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 1 3 10367 15605 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999807790876473 0.99943838714673 0.999960360103688 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2422 2512 False False 0.501752355229735 0.00956153582768186 6.25014259670444 0 0 0.000355765720726338 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 1 3 7735 11871 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999747347145022 0.999261820436506 0.999947893876346 0.25 0.00630946320970987 0.805879550316756 NA NA NA 0 0 0.707598226178713 NA NA NA NA 2000 2071 False False 0 0 0 0 0 0 0 0.511570782159017 0.0097482170621519 6.37282132403124 0 0 0.000476793790149404 0.999747347145022 0.999261820436506 0.999947893876346 4 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Val85Ile Rv2477c_p.Val85Ile 2 missense_variant (see "Genomic_coordinates" sheet) 1 40 3 37 48 52 10320 15556 0.00462962962962962 0.00341543741623323 0.00613358439529863 0.996668375192209 0.995633284442868 0.997510812568786 0.48 0.379005480177958 0.582210234593693 0.075 0.0157421798510415 0.203864748732898 0.0545454545454545 0.0113930062727087 0.151234954766599 0.122218730358265 0.0241315148641751 0.386171423209928 6.1445844872025e-06 30 2512 True False 1.39141323792486 0.919184146377401 2.10223051453133 0.000290613193839 5.99354373913133e-05 0.000849057862067016 0.996668375192209 0.995633284442868 0.997510812568786 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 39 3 36 46 50 7690 11824 0.00594622543950361 0.00435657659259494 0.00792355268197464 0.995789119083712 0.99445220186182 0.996873036111105 0.479166666666666 0.376089185130921 0.583564083301576 0.0769230769230769 0.0161533003106583 0.208701921226443 0.0566037735849056 0.0118287188591336 0.156629462172374 0.128131772865192 0.0252354232019671 0.405779837927914 1.89732754659815e-05 25 2071 True False 0 0 0 0 0 0 0 1.41457477243172 0.925826243727592 2.15701735800921 0.000389964903158715 8.04273592698829e-05 0.00113921581847742 0.995789119083712 0.99445220186182 0.996873036111105 37 3) Uncertain significance New Uncertain no 0 +Streptomycin Rv2477c p.Val89Met Rv2477c_p.Val89Met 2 missense_variant (see "Genomic_coordinates" sheet) NA 0 0 0 2 1 10366 15607 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999935930292158 0.99964307871082 0.999998377896754 0.666666666666666 0.0942993240502461 0.991596241340387 NA NA NA 0 0 0.975 NA NA NA NA 2427 2512 False False 3.01119043025274 0.156729426968348 177.474331043773 0 0 0.000355800035063835 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 2005 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 c.-100T>C whiB7_c.-100T>C 1 upstream_gene_variant 3568779 0 0 0 0 84 135 10284 15473 0.00810185185185185 0.0064673532048863 0.010020957592303 0.991350589441312 0.989770518429906 0.992743185248582 0.383561643835616 0.318850992933478 0.451470380502668 NA NA NA 0 0 0.0269550815831828 NA NA NA NA 1458 2512 False True 0.93617701715718 0.703468294601013 1.2398817464 0 0 0.000358636516057017 0.991350589441312 0.989770518429906 0.992743185248582 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 36 101 7700 11773 0.0046535677352637 0.00326136650775108 0.00643673373862268 0.991494020549098 0.98967393240475 0.993066552414688 0.262773722627737 0.191320185552242 0.344775308049479 NA NA NA 0 0 0.0358646203900037 NA NA NA NA 1198 2071 False True 0 1 1 0 0 0 0 0.544976211906904 0.36134399168989 0.805508504026696 0 0 0.000478960515555118 0.991494020549098 0.98967393240475 0.993066552414688 215 Not assoc w R 5) Not assoc w R No change yes 1 +Streptomycin whiB7 c.-103G>C whiB7_c.-103G>C 1 upstream_gene_variant 3568782 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1527 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1256 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 7 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 c.-115C>G whiB7_c.-115C>G 1 upstream_gene_variant 3568794 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1476 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1214 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 c.-116A>G whiB7_c.-116A>G 1 upstream_gene_variant 3568795 0 0 0 0 61 1 10307 15607 0.00588348765432098 0.00450330271174146 0.00755125451913263 0.999935930292158 0.99964307871082 0.999998377896754 0.983870967741935 0.91337898779308 0.999591731622542 NA NA NA 0 0 0.975 NA NA NA NA 1469 2512 False False 92.3670321140972 15.954300827926 3633.82473395917 0 0 0.00035783636432893 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 56 0 7680 11874 0.00723888314374353 0.00547267327183907 0.00939012257082594 1 0.999689379610589 1 1 0.936249903337637 1 NA NA NA NA NA NA NA NA NA NA 1207 2071 False False 0 0 0 0 0 0 0 Inf 22.6950663895932 Inf 0 0 0.000480207509036754 1 0.999689379610589 1 149 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-117_-116insG whiB7_c.-117_-116insG 1 upstream_gene_variant 3568795 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1496 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1230 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 c.-118G>A whiB7_c.-118G>A 1 upstream_gene_variant 3568797 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-118G>T whiB7_c.-118G>T 1 upstream_gene_variant 3568797 1 5 0 5 0 5 10368 15603 0 0 0.000355731413006942 0.999679651460789 0.999252573060182 0.999895975781355 0 0 0.521823750104981 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.64266120859479 0.164659119890409 198.5 2512 False False 0 0 1.64266120859479 0 0 0.000355731413006942 0.999679651460789 0.999252573060182 0.999895975781355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 7736 11870 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.32513012450998 0.158605093840654 142 2071 False False 0 0 0 0 0 0 0 0 0 2.32513012450998 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 NA 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-126A>G whiB7_c.-126A>G 1 upstream_gene_variant 3568805 1 3 0 3 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.6429945931141 0.280491932584249 243 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 1 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-128A>G whiB7_c.-128A>G 1 upstream_gene_variant 3568807 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1465 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 c.-140C>G whiB7_c.-140C>G 1 upstream_gene_variant 3568819 1 1 0 1 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 58.6634076928655 1 973.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 59.8138891519084 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 c.141G>T whiB7_c.141G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 4 10368 15604 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 2.28044779470556 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 4 7736 11870 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 0 0 0.602364635616474 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 2.32513012450998 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin whiB7 c.-147T>C whiB7_c.-147T>C 1 upstream_gene_variant 3568826 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1484 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1220 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-151T>A whiB7_c.-151T>A 1 upstream_gene_variant 3568830 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 c.-151T>G whiB7_c.-151T>G 1 upstream_gene_variant 3568830 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 c.-154C>T whiB7_c.-154C>T 1 upstream_gene_variant 3568833 1 1 0 1 2 2 10366 15606 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999871860584315 0.999537193839207 0.999984481345552 0.5 0.067585986488543 0.932414013511457 0 0 0.975 0 0 0.841886116991581 0 0 58.6653062545381 1 973.5 2512 False False 1.50549874590005 0.10909391082996 20.7696540777406 0 0 0.000355800035063835 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 7734 11873 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999915782381674 0.999530859783396 0.999997867796783 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 59.821615810862 1 806.5 2071 False False 0 0 0 0 0 0 0 3.07033876389966 0.159799628612092 180.959738606129 0 0 0.000476855424503066 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 c.-159G>A whiB7_c.-159G>A 1 upstream_gene_variant 3568838 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1480 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1216 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.15A>C whiB7_c.15A>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin whiB7 c.-161A>G whiB7_c.-161A>G 1 upstream_gene_variant 3568840 0 0 0 0 7 1 10361 15607 0.000675154320987654 0.000271488767107418 0.00139057803317028 0.999935930292158 0.99964307871082 0.999998377896754 0.875 0.473490329124793 0.996840276468748 NA NA NA 0 0 0.975 NA NA NA NA 1517 2512 False False 10.5442524852813 1.35425443486503 474.171593318211 0 0 0.000355971706089883 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 5 0 7731 11874 0.000646328852119958 0.0002098934625097 0.00150766595359595 1 0.999689379610589 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA 1250 2071 False False 0 0 0 0 0 0 0 Inf 1.40693962335604 Inf 0 0 0.000477040423209609 1 0.999689379610589 1 3 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 c.-166delG whiB7_c.-166delG 1 upstream_gene_variant 3568844 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1524 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1254 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 5 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 c.-166G>A whiB7_c.-166G>A 1 upstream_gene_variant 3568845 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-172A>G whiB7_c.-172A>G 1 upstream_gene_variant 3568851 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-176delG whiB7_c.-176delG 1 upstream_gene_variant 3568854 0 0 0 0 25 0 10343 15608 0.00241126543209876 0.00156103294612564 0.0035574594829627 1 0.99976368249849 1 1 0.862814828469287 1 NA NA NA NA NA NA NA NA NA NA 1491 2512 False False Inf 9.48683857803826 Inf 0 0 0.000356591095836268 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 17 0 7719 11874 0.00219751809720785 0.00128064014327926 0.00351611538908953 1 0.999689379610589 1 1 0.804935677030906 1 NA NA NA NA NA NA NA NA NA NA 1227 2071 False False 0 0 0 0 0 0 0 Inf 6.34564587707818 Inf 0 0 0.000477781855692221 1 0.999689379610589 1 143 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 c.177G>T whiB7_c.177G>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 13 10368 15595 0 0 0.000355731413006942 0.999167093798052 0.998576126182689 0.999556440358575 0 0 0.24705263800047 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0.493685891087786 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 13 7736 11861 0 0 0.000476732171726368 0.998905170961765 0.998128536682641 0.999416924941029 0 0 0.24705263800047 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 0.503273172275989 NA NA NA NA NA NA 196 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin whiB7 c.-178C>T whiB7_c.-178C>T 1 upstream_gene_variant 3568857 1 40 1 39 13 60 10355 15548 0.00125385802469135 0.000667790166179422 0.00214318097672708 0.996155817529472 0.995054508199936 0.997065240454966 0.178082191780821 0.0983731777330085 0.285253793641702 0.025 0.000632744932049419 0.131585858482765 0.0163934426229508 0.00041495991283974 0.0879881229227452 0.0384999195235795 0.000955004640521178 0.227605420157797 7.92380649809933e-08 20 2512 True False 0.325324319974247 0.163739928390383 0.599633922946353 9.65623792970258e-05 2.44474478915486e-06 0.000537892405271169 0.996155817529472 0.995054508199936 0.997065240454966 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 31 1 30 11 48 7725 11826 0.0014219234746639 0.000710026047388019 0.00254278626393864 0.995957554320363 0.994643835407194 0.997017960688927 0.186440677966101 0.0969194651172766 0.309148653421927 0.032258064516129 0.000816370071846613 0.167021116230227 0.0204081632653061 0.000516556497593286 0.108541763968406 0.0510291262135922 0.00125495234258785 0.307123880549868 7.00849304463352e-06 19 2071 True False 0 0 0 0 0 0 0 0.350825242718446 0.164182071766509 0.685627740100164 0.000129433083096039 3.27695657540623e-06 0.000720941656585088 0.995957554320363 0.994643835407194 0.997017960688927 183 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.180T>G whiB7_c.180T>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 8.01564764707657 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 8.17274275317631 NA NA NA NA NA NA 2 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin whiB7 c.-182G>A whiB7_c.-182G>A 1 upstream_gene_variant 3568861 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.186C>G whiB7_c.186C>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin whiB7 c.18C>A whiB7_c.18C>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 5 0 10363 15608 0.000482253086419753 0.000156604214122162 0.00112505595550109 1 0.99976368249849 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 1.37979907306709 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 5 0 7731 11874 0.000646328852119958 0.0002098934625097 0.00150766595359595 1 0.999689379610589 1 1 0.478176249895018 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 1.40693962335604 Inf NA NA NA NA NA NA 7 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin whiB7 c.18C>T whiB7_c.18C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 3.6429945931141 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin whiB7 c.-195C>T whiB7_c.-195C>T 1 upstream_gene_variant 3568874 1 1 0 1 7 1 10361 15607 0.000675154320987654 0.000271488767107418 0.00139057803317028 0.999935930292158 0.99964307871082 0.999998377896754 0.875 0.473490329124793 0.996840276468748 0 0 0.975 0 0 0.975 0 0 58.6973482033062 1 973.5 2512 False False 10.5442524852813 1.35425443486503 474.171593318211 0 0 0.000355971706089883 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 4 1 7732 11873 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.999915782381674 0.999530859783396 0.999997867796783 0.8 0.28358206388191 0.994949236620532 0 0 0.975 0 0 0.975 0 0 59.8370751190188 1 806.5 2071 False False 0 0 0 0 0 0 0 6.14226590791515 0.607630898004113 302.048561734113 0 0 0.000476978741026985 0.999915782381674 0.999530859783396 0.999997867796783 16 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-1C>A whiB7_c.-1C>A 1 upstream_gene_variant 3568680 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1481 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1217 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-203_-202insCC whiB7_c.-203_-202insCC 1 upstream_gene_variant 3568881 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1528 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 c.-203C>T whiB7_c.-203C>T 1 upstream_gene_variant 3568882 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1470 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1208 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-205_-204insA whiB7_c.-205_-204insA 1 upstream_gene_variant 3568883 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1500 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1233 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 7 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 c.-209A>G whiB7_c.-209A>G 1 upstream_gene_variant 3568888 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 c.-210C>T whiB7_c.-210C>T 1 upstream_gene_variant 3568889 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-211_-210insG whiB7_c.-211_-210insG 1 upstream_gene_variant 3568889 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1520 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 c.-214_-213insA whiB7_c.-214_-213insA 1 upstream_gene_variant 3568892 0 0 0 0 3 0 10365 15608 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 1 0.99976368249849 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1482 2512 False False Inf 0.622129167636411 Inf 0 0 0.000355834356021348 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 7733 11874 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 1 0.999689379610589 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1218 2071 False False 0 0 0 0 0 0 0 Inf 0.634338273987677 Inf 0 0 0.000476917074793532 1 0.999689379610589 1 5 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 c.-214A>C whiB7_c.-214A>C 1 upstream_gene_variant 3568893 0 0 0 0 3 0 10365 15608 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 1 0.99976368249849 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1536 2512 False False Inf 0.622129167636411 Inf 0 0 0.000355834356021348 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 7733 11874 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 1 0.999689379610589 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1264 2071 False False 0 0 0 0 0 0 0 Inf 0.634338273987677 Inf 0 0 0.000476917074793532 1 0.999689379610589 1 3 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 c.-215C>T whiB7_c.-215C>T 1 upstream_gene_variant 3568894 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-215delC whiB7_c.-215delC 1 upstream_gene_variant 3568893 1 2 0 2 7 3 10361 15605 0.000675154320987654 0.000271488767107418 0.00139057803317028 0.999807790876473 0.99943838714673 0.999960360103688 0.7 0.347547149940002 0.933260488822265 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.02054937603945 0.520387140145007 561 2512 False False 3.51430042145224 0.802019002880655 21.0638674909524 0 0 0.000355971706089883 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 4 2 7732 11872 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.999831564763348 0.99939168785815 0.999979601060482 0.666666666666666 0.222778095503512 0.956728131707258 0 0 0.975 0 0 0.841886116991581 0 0 59.8320404942171 1 806.5 2071 False False 0 0 0 0 0 0 0 3.07087428867046 0.439962791152193 33.9588674822466 0 0 0.000476978741026985 0.999831564763348 0.99939168785815 0.999979601060482 18 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 c.-217C>G whiB7_c.-217C>G 1 upstream_gene_variant 3568896 0 0 0 0 5 1 10363 15607 0.000482253086419753 0.000156604214122162 0.00112505595550109 0.999935930292158 0.99964307871082 0.999998377896754 0.833333333333333 0.358765421002325 0.99578925548551 NA NA NA 0 0 0.975 NA NA NA NA 1537 2512 False False 7.53015536041686 0.842353453161053 355.554202953959 0 0 0.000355903017804084 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 4 1 7732 11873 0.000517063081695967 0.000140899683864147 0.00132335286075948 0.999915782381674 0.999530859783396 0.999997867796783 0.8 0.28358206388191 0.994949236620532 NA NA NA 0 0 0.975 NA NA NA NA 1265 2071 False False 0 0 0 0 0 0 0 6.14226590791515 0.607630898004113 302.048561734113 0 0 0.000476978741026985 0.999915782381674 0.999530859783396 0.999997867796783 3 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-217C>T whiB7_c.-217C>T 1 upstream_gene_variant 3568896 1 5 0 5 1 5 10367 15603 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999679651460789 0.999252573060182 0.999895975781355 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.64281965943779 0.164656519955818 194 2512 False False 0.30101282916948 0.00636796908209055 2.69069235774657 0 0 0.000355765720726338 0.999679651460789 0.999252573060182 0.999895975781355 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 5 0 5 1 5 7735 11869 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999578911908371 0.999017596768841 0.999863260157969 0.166666666666666 0.00421074451448947 0.641234578997674 0 0 0.521823750104981 0 0 0.521823750104981 0 0 1.67502148051906 0.164216700356639 156.5 2071 False False 0 0 0 0 0 0 0 0.306890756302521 0.00649200912492085 2.74344385104518 0 0 0.000476793790149404 0.999578911908371 0.999017596768841 0.999863260157969 NA 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-22C>T whiB7_c.-22C>T 1 upstream_gene_variant 3568701 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-232C>T whiB7_c.-232C>T 1 upstream_gene_variant 3568911 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1466 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1204 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-235T>C whiB7_c.-235T>C 1 upstream_gene_variant 3568914 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1479 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 c.-238C>T whiB7_c.-238C>T 1 upstream_gene_variant 3568917 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-240C>G whiB7_c.-240C>G 1 upstream_gene_variant 3568919 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-242G>C whiB7_c.-242G>C 1 upstream_gene_variant 3568921 0 0 0 0 10 93 10358 15515 0.000964506172839506 0.000462612020337809 0.00177304351401163 0.994041517170681 0.992705355436545 0.995188121007243 0.0970873786407767 0.0475464184392118 0.171306280354348 NA NA NA 0 0 0.0388889985342758 NA NA NA NA 1541 2512 False True 0.161061939553241 0.0747546275995544 0.309869669263775 0 0 0.000356074788245403 0.994041517170681 0.992705355436545 0.995188121007243 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 9 76 7727 11798 0.00116339193381592 0.000532110502771461 0.00220732634615895 0.993599461007242 0.991995229341366 0.994953885708195 0.105882352941176 0.0495726580242452 0.191503897517815 NA NA NA 0 0 0.0473787538669306 NA NA NA NA 1269 2071 False True 0 0 0 0 1 0 0 0.180811644745356 0.079597060716035 0.36196220161642 0 0 0.00047728731155563 0.993599461007242 0.991995229341366 0.994953885708195 61 5) Not assoc w R UP from Uncertain to NotAwR yes 4 +Streptomycin whiB7 c.-249C>A whiB7_c.-249C>A 1 upstream_gene_variant 3568928 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1529 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1257 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 c.-250G>A whiB7_c.-250G>A 1 upstream_gene_variant 3568929 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1542 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1270 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 1 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 c.-252C>T whiB7_c.-252C>T 1 upstream_gene_variant 3568931 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-257G>A whiB7_c.-257G>A 1 upstream_gene_variant 3568936 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1485 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1221 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 1 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 c.-265A>C whiB7_c.-265A>C 1 upstream_gene_variant 3568944 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1486 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1222 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 c.267T>C whiB7_c.267T>C 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin whiB7 c.-26A>C whiB7_c.-26A>C 1 upstream_gene_variant 3568705 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 4 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-271A>G whiB7_c.-271A>G 1 upstream_gene_variant 3568950 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 c.-278G>C whiB7_c.-278G>C 1 upstream_gene_variant 3568957 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1492 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1228 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 c.-279G>T whiB7_c.-279G>T 1 upstream_gene_variant 3568958 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-282C>T whiB7_c.-282C>T 1 upstream_gene_variant 3568961 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1487 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1223 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 c.-287G>C whiB7_c.-287G>C 1 upstream_gene_variant 3568966 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1501 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1234 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-289G>A whiB7_c.-289G>A 1 upstream_gene_variant 3568968 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1495 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 c.-290A>C whiB7_c.-290A>C 1 upstream_gene_variant 3568969 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-295A>C whiB7_c.-295A>C 1 upstream_gene_variant 3568974 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-307_-306insGG whiB7_c.-307_-306insGG 1 upstream_gene_variant 3568985 1 9 0 9 0 9 10368 15599 0 0 0.000355731413006942 0.99942337262942 0.998905665124108 0.999736296428239 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.336267116879942 0 0 0.762426796904344 0.0139347599364063 74.5 2512 False False 0 0 0.762426796904344 0 0 0.000355731413006942 0.99942337262942 0.998905665124108 0.999736296428239 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 7 0 7 0 7 7736 11867 0 0 0.000476732171726368 0.999410476671719 0.998785736251934 0.999762949244471 0 0 0.409616397225003 0 0 0.409616397225003 0 0 0.409616397225003 0 0 1.06467742986826 0.047267663661775 82 2071 False False 0 0 0 0 0 0 0 0 0 1.06467742986826 0 0 0.000476732171726368 0.999410476671719 0.998785736251934 0.999762949244471 5 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-317_-316insG whiB7_c.-317_-316insG 1 upstream_gene_variant 3568995 1 1 0 1 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 58.6540000158548 1 973.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 59.801132462225 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 4 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-317delG whiB7_c.-317delG 1 upstream_gene_variant 3568995 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 c.-317G>A whiB7_c.-317G>A 1 upstream_gene_variant 3568996 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1539 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1267 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 c.-31C>T whiB7_c.-31C>T 1 upstream_gene_variant 3568710 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1525 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-321G>C whiB7_c.-321G>C 1 upstream_gene_variant 3569000 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 c.-322G>C whiB7_c.-322G>C 1 upstream_gene_variant 3569001 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-325A>G whiB7_c.-325A>G 1 upstream_gene_variant 3569004 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 c.-335T>C whiB7_c.-335T>C 1 upstream_gene_variant 3569014 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1460 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1200 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-336C>T whiB7_c.-336C>T 1 upstream_gene_variant 3569015 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 3 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-338G>T whiB7_c.-338G>T 1 upstream_gene_variant 3569017 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1488 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1224 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 c.-33C>G whiB7_c.-33C>G 1 upstream_gene_variant 3568712 1 1 0 1 1 2 10367 15606 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999871860584315 0.999537193839207 0.999984481345552 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 58.6596525903968 1 973.5 2512 False False 0.752676762805054 0.0127620362920002 14.460605698152 0 0 0.000355765720726338 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 0 0 0.975 0 0 0.841886116991581 0 0 59.8088564761233 1 806.5 2071 False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 0 0 0.000476793790149404 0.999831564763348 0.99939168785815 0.999979601060482 8 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.33C>T whiB7_c.33C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin whiB7 c.-340C>T whiB7_c.-340C>T 1 upstream_gene_variant 3569019 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1489 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1225 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-341C>T whiB7_c.-341C>T 1 upstream_gene_variant 3569020 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-343T>G whiB7_c.-343T>G 1 upstream_gene_variant 3569022 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 c.-347C>G whiB7_c.-347C>G 1 upstream_gene_variant 3569026 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 c.-347C>T whiB7_c.-347C>T 1 upstream_gene_variant 3569026 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1518 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1251 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 c.-350A>G whiB7_c.-350A>G 1 upstream_gene_variant 3569029 1 27 1 26 63 48 10305 15560 0.00607638888888888 0.0046723301590596 0.00776773481999848 0.996924654023577 0.995924581274419 0.997731638523577 0.567567567567567 0.47015632009064 0.661282688472964 0.037037037037037 0.000937257091944708 0.189705617413044 0.0204081632653061 0.000516556497593286 0.108541763968406 0.0580748703019445 0.00142070099454564 0.353638113843842 3.2500518709874e-05 33 2512 True False 1.98180494905385 1.33858140613136 2.95028568596412 9.70308558121482e-05 2.45660555854291e-06 0.00054050143451253 0.996924654023577 0.995924581274419 0.997731638523577 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 22 0 22 56 32 7680 11842 0.00723888314374353 0.00547267327183907 0.00939012257082594 0.997305036213576 0.99619762638504 0.99815593879969 0.636363636363636 0.526941589911829 0.736326357741091 0 0 0.154372512815574 0 0 0.108881160679352 0 0 0.281608025405747 2.42575996628372e-05 26 2071 True False 0 0 0 0 0 0 0 2.69837239583333 1.71564655235182 4.31001674481269 0 0 0.000480207509036754 0.997305036213576 0.99619762638504 0.99815593879969 70 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-351C>T whiB7_c.-351C>T 1 upstream_gene_variant 3569030 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1544 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 c.-353C>A whiB7_c.-353C>A 1 upstream_gene_variant 3569032 1 1 0 1 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 58.6540000158548 1 973.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 59.801132462225 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 2 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-354T>G whiB7_c.-354T>G 1 upstream_gene_variant 3569033 1 1 0 1 0 3 10368 15605 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 58.6502452744631 1 973.5 2512 False False 0 0 3.6429945931141 0 0 0.000355731413006942 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 0 0 0.975 0 0 0.707598226178713 0 0 59.7961004349848 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 3.71438150990605 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 NA 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-355G>A whiB7_c.-355G>A 1 upstream_gene_variant 3569034 1 1 0 1 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 58.6634076928655 1 973.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 59.8138891519084 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 c.-358C>T whiB7_c.-358C>T 1 upstream_gene_variant 3569037 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 c.-360T>C whiB7_c.-360T>C 1 upstream_gene_variant 3569039 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 4 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-360T>G whiB7_c.-360T>G 1 upstream_gene_variant 3569039 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1535 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1263 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-368G>A whiB7_c.-368G>A 1 upstream_gene_variant 3569047 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1521 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1252 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-37G>A whiB7_c.-37G>A 1 upstream_gene_variant 3568716 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1509 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 c.-386T>C whiB7_c.-386T>C 1 upstream_gene_variant 3569065 1 7 0 7 1 10 10367 15598 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999359302921578 0.998822051949738 0.999692719453314 0.0909090909090909 0.00229897221381426 0.412779916988382 0 0 0.409616397225003 0 0 0.30849710781876 0 0 1.04416887229027 0.0468668619381455 97 2512 False False 0.150458184624288 0.00347081599231064 1.05796227786788 0 0 0.000355765720726338 0.999359302921578 0.998822051949738 0.999692719453314 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 3 0 3 0 6 7736 11868 0 0 0.000476732171726368 0.999494694290045 0.998900489118281 0.999814539856352 0 0 0.4592581264399 0 0 0.707598226178713 0 0 0.4592581264399 0 0 3.71344285374342 0.283320678861821 175 2071 False False 0 0 0 0 0 0 0 0 0 1.30338194607257 0 0 0.000476732171726368 0.999494694290045 0.998900489118281 0.999814539856352 79 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-390G>T whiB7_c.-390G>T 1 upstream_gene_variant 3569069 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-401T>G whiB7_c.-401T>G 1 upstream_gene_variant 3569080 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1530 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1258 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 c.42A>G whiB7_c.42A>G 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin whiB7 c.-49A>G whiB7_c.-49A>G 1 upstream_gene_variant 3568728 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1464 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-51G>C whiB7_c.-51G>C 1 upstream_gene_variant 3568730 0 0 0 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1526 2512 False False Inf 0.282736080598822 Inf 0 0 0.000355800035063835 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1255 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0 0 0.000476855424503066 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 c.-52_-51insC whiB7_c.-52_-51insC 1 upstream_gene_variant 3568730 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1483 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1219 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-52C>T whiB7_c.-52C>T 1 upstream_gene_variant 3568731 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1510 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1243 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-53C>T whiB7_c.-53C>T 1 upstream_gene_variant 3568732 1 8 0 8 0 16 10368 15592 0 0 0.000355731413006942 0.998974884674526 0.998335809333792 0.999413948080433 0 0 0.205907214207822 0 0 0.369416647552819 0 0 0.205907214207822 0 0 0.881279090870531 0.0253603181978434 82 2512 False False 0 0 0.390047640252407 0 0 0.000355731413006942 0.998974884674526 0.998335809333792 0.999413948080433 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 6 0 6 0 12 7736 11862 0 0 0.000476732171726368 0.998989388580091 0.998235331388827 0.999477696754876 0 0 0.264648469397051 0 0 0.4592581264399 0 0 0.264648469397051 0 0 1.30272308773624 0.0877120058609169 106 2071 False False 0 0 0 0 0 0 0 0 0 0.552062026148079 0 0 0.000476732171726368 0.998989388580091 0.998235331388827 0.999477696754876 23 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-55delG whiB7_c.-55delG 1 upstream_gene_variant 3568733 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1515 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1248 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 3 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-55G>A whiB7_c.-55G>A 1 upstream_gene_variant 3568734 0 0 0 0 9 0 10359 15608 0.000868055555555555 0.000397004661559041 0.00164719739830421 1 0.99976368249849 1 1 0.663732883120057 1 NA NA NA NA NA NA NA NA NA NA 1502 2512 False False Inf 2.97305673502534 Inf 0 0 0.000356040420894094 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 8 0 7728 11874 0.00103412616339193 0.000446564649135067 0.00203661849802302 1 0.999689379610589 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 1235 2071 False False 0 0 0 0 0 0 0 Inf 2.62150725084646 Inf 0 0 0.000477225565514406 1 0.999689379610589 1 4 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-55G>T whiB7_c.-55G>T 1 upstream_gene_variant 3568734 0 0 0 0 4 0 10364 15608 0.000385802469135802 0.000105127872737001 0.000987510251175401 1 0.99976368249849 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 1532 2512 False False Inf 0.993868422549659 Inf 0 0 0.000355868683600791 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 3 0 7733 11874 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 1 0.999689379610589 1 1 0.292401773821286 1 NA NA NA NA NA NA NA NA NA NA 1260 2071 False False 0 0 0 0 0 0 0 Inf 0.634338273987677 Inf 0 0 0.000476917074793532 1 0.999689379610589 1 1 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-56G>A whiB7_c.-56G>A 1 upstream_gene_variant 3568735 0 0 0 0 4 0 10364 15608 0.000385802469135802 0.000105127872737001 0.000987510251175401 1 0.99976368249849 1 1 0.397635364383525 1 NA NA NA NA NA NA NA NA NA NA 1511 2512 False False Inf 0.993868422549659 Inf 0 0 0.000355868683600791 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1244 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 3 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-56G>T whiB7_c.-56G>T 1 upstream_gene_variant 3568735 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1507 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1240 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-57delT whiB7_c.-57delT 1 upstream_gene_variant 3568735 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.57G>A whiB7_c.57G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.0385997978146249 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin whiB7 c.-57T>C whiB7_c.-57T>C 1 upstream_gene_variant 3568736 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1497 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 c.-57T>G whiB7_c.-57T>G 1 upstream_gene_variant 3568736 2 2 1 1 25 1 10343 15607 0.00241126543209876 0.00156103294612564 0.0035574594829627 0.999935930292158 0.99964307871082 0.999998377896754 0.961538461538461 0.803630353237461 0.999026712106664 0.5 0.012579117093425 0.987420882906574 0.5 0.012579117093425 0.987420882906574 1.50894324664023 0.0192209884690198 118.348412815762 1 610 2512 False False 37.7235811660059 6.17234803546417 1537.52658538519 9.66744006187161e-05 2.44758091652991e-06 0.000538516272493246 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 0 1 24 1 7712 11873 0.0031023784901758 0.00198873287845359 0.00461259875829844 0.999915782381674 0.999530859783396 0.999997867796783 0.96 0.796483086077586 0.998987800300689 0 0 0.975 0 0 0.975 0 0 59.9921087944311 1 806.5 2071 False False 0 0 0 0 0 0 0 36.9491701244813 6.02164287263879 1508.5898961904 0 0 0.000478215423271722 0.999915782381674 0.999530859783396 0.999997867796783 55 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-58C>T whiB7_c.-58C>T 1 upstream_gene_variant 3568737 1 1 0 1 1 3 10367 15605 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999807790876473 0.99943838714673 0.999960360103688 0.25 0.00630946320970987 0.805879550316756 0 0 0.975 0 0 0.707598226178713 0 0 58.655897487487 1 973.5 2512 False False 0.501752355229735 0.00956153582768186 6.25014259670444 0 0 0.000355765720726338 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 2 7735 11872 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999831564763348 0.99939168785815 0.999979601060482 0.333333333333333 0.00840375865961264 0.905700675949754 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1241 2071 False False 0 0 0 0 0 0 0 0.767420814479638 0.0130114906060525 14.7444541307454 0 0 0.000476793790149404 0.999831564763348 0.99939168785815 0.999979601060482 3 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.60C>T whiB7_c.60C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin whiB7 c.-61T>C whiB7_c.-61T>C 1 upstream_gene_variant 3568740 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-65A>G whiB7_c.-65A>G 1 upstream_gene_variant 3568744 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1459 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1199 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-66C>G whiB7_c.-66C>G 1 upstream_gene_variant 3568745 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1531 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1259 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-71C>G whiB7_c.-71C>G 1 upstream_gene_variant 3568750 1 1 0 1 0 4 10368 15604 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 0 0 0.602364635616474 0 0 0.975 0 0 0.602364635616474 0 0 58.6464905326305 1 973.5 2512 False False 0 0 2.28044779470556 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1261 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 3 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.75C>T whiB7_c.75C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin whiB7 c.-78A>G whiB7_c.-78A>G 1 upstream_gene_variant 3568757 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-7A>G whiB7_c.-7A>G 1 upstream_gene_variant 3568686 2 1 0 1 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 58.6634076928655 1 973.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 0 1 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 59.8138891519084 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-80A>C whiB7_c.-80A>C 1 upstream_gene_variant 3568759 1 2 1 1 55 3 10313 15605 0.00530478395061728 0.00399871540293604 0.00689937703419218 0.999807790876473 0.99943838714673 0.999960360103688 0.948275862068965 0.856195372724655 0.989203521915705 0.5 0.012579117093425 0.987420882906574 0.25 0.00630946320970987 0.805879550316756 1.51313875690875 0.0192744266124739 118.677151569487 1 973.5 2512 False False 27.7408772099938 9.005881751088 138.644515252598 9.69555943377932e-05 2.45470010766571e-06 0.0005400822903196 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 48 3 7688 11871 0.0062047569803516 0.00457833777002372 0.00821828431630522 0.999747347145022 0.999261820436506 0.999947893876346 0.941176470588235 0.837577781927949 0.98770091174476 0 0 0.975 0 0 0.707598226178713 0 0 60.1690861807365 1 806.5 2071 False False 0 0 0 0 0 0 0 24.7055150884495 7.95719873373118 123.68242762329 0 0 0.000479707933270959 0.999747347145022 0.999261820436506 0.999947893876346 16 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-80A>G whiB7_c.-80A>G 1 upstream_gene_variant 3568759 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 c.-89A>G whiB7_c.-89A>G 1 upstream_gene_variant 3568768 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1503 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1236 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 10 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 c.-8A>T whiB7_c.-8A>T 1 upstream_gene_variant 3568687 0 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1543 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1271 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 6 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 c.90C>T whiB7_c.90C>T 1 synonymous_variant (see "Genomic_coordinates" sheet) 1 NA NA NA 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 58.6577547568054 NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 NA NA NA 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 0 0 59.8061644886732 NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin whiB7 c.-94G>T whiB7_c.-94G>T 1 upstream_gene_variant 3568773 1 4 0 4 0 4 10368 15604 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.28044779470556 0.155697794255122 153.5 2512 False False 0 0 2.28044779470556 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 4 0 4 0 4 7736 11870 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 0 0 0.602364635616474 0 0 0.602364635616474 0 0 0.602364635616474 0 0 2.32513012450998 0.158605093840654 142 2071 False False 0 0 0 0 0 0 0 0 0 2.32513012450998 0 0 0.000476732171726368 0.999663129526697 0.999137704464366 0.999908206750254 NA 3) Uncertain significance No change no 1 +Streptomycin whiB7 c.-97G>A whiB7_c.-97G>A 1 upstream_gene_variant 3568776 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1547 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 c.-99C>T whiB7_c.-99C>T 1 upstream_gene_variant 3568778 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 c.99G>A whiB7_c.99G>A 1 synonymous_variant (see "Genomic_coordinates" sheet) NA NA NA NA 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False Inf 0.282736080598822 Inf NA NA NA NA NA NA 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA NA NA False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf NA NA NA NA NA NA NA Silent mutation 4) Not assoc w R - Interim Now listed Silent mutation no 0 +Streptomycin whiB7 LoF whiB7_LoF 1 LoF (see "Genomic_coordinates" sheet) 1 328 2 326 67 451 10301 15157 0.00646219135802469 0.00501151635309248 0.00819958899142936 0.971104561763198 0.96835513665598 0.973676475445273 0.129343629343629 0.101663402288276 0.161333645516134 0.00609756097560975 0.00073929783226701 0.0218517537019184 0.00441501103752759 0.00053512624585936 0.0158568308942591 0.00902705854396172 0.00105930515034425 0.032877651056783 1.53491167895897e-69 6 2512 True False 0.218590923189813 0.166320869650687 0.283449900746594 0.000194118217994758 2.3509481362176e-05 0.000701043974325983 0.971104561763198 0.96835513665598 0.973676475445273 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 317 2 315 58 428 7678 11446 0.00749741468459152 0.00569788135398402 0.00968149981644972 0.963954859356577 0.960444269578375 0.967235554455303 0.119341563786008 0.0918803175920401 0.151532570888631 0.00630914826498422 0.000764982465468398 0.0226037685342535 0.00465116279069767 0.000563774560507467 0.0166998349945 0.00946509714418024 0.00116204232527751 0.034500648797795 3.00536677552652e-66 6 2071 True False 0 0 0 0 0 0 0 0.202017902831977 0.150602156033919 0.266713180904145 0.000260416666666666 3.15392225447662e-05 0.000940394611397825 0.963954859356577 0.960444269578375 0.967235554455303 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 p.Ala34Pro whiB7_p.Ala34Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1504 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1237 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 p.Ala39Thr whiB7_p.Ala39Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1505 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1238 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance No change no 1 +Streptomycin whiB7 p.Ala55Glu whiB7_p.Ala55Glu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin whiB7 p.Ala56Pro whiB7_p.Ala56Pro 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 p.Ala60fs whiB7_p.Ala60fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin whiB7 p.Ala92Thr whiB7_p.Ala92Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 3 0 10365 15608 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 1 0.99976368249849 1 1 0.292401773821286 1 1 0.025 1 1 0.025 1 Inf 0.0386072452937345 Inf 0.399091399091399 297.5 2512 False False Inf 0.622129167636411 Inf 9.64692263168049e-05 2.44238636565143e-06 0.000537373619049235 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 3 0 7733 11874 0.000387797311271975 7.99802696527417e-05 0.00113288592972291 1 0.999689379610589 1 1 0.292401773821286 1 1 0.025 1 1 0.025 1 Inf 0.0393664039281761 Inf 0.394430844553243 227 2071 False False 0 0 0 0 0 0 0 Inf 0.634338273987677 Inf 0.00012929919834497 3.27356691808869e-06 0.000720196139555935 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 p.Ala92Val whiB7_p.Ala92Val 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0385997978146249 Inf 0.399137665537419 362.5 2512 False False Inf 0.0385997978146249 Inf 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 1 0.025 1 1 0.025 1 Inf 0.0393562263478767 Inf 0.39449260581336 289.5 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 p.Arg12fs whiB7_p.Arg12fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 58.6634076928655 1 973.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance No change no 1 +Streptomycin whiB7 p.Arg50Leu whiB7_p.Arg50Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1508 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1242 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 4 3) Uncertain significance No change no 1 +Streptomycin whiB7 p.Arg50Pro whiB7_p.Arg50Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1540 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1268 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 1 3) Uncertain significance No change no 1 +Streptomycin whiB7 p.Arg59Trp whiB7_p.Arg59Trp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin whiB7 p.Arg81Cys whiB7_p.Arg81Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin whiB7 p.Arg81fs whiB7_p.Arg81fs 1 frameshift (see "Genomic_coordinates" sheet) 1 3 0 3 13 3 10355 15605 0.00125385802469135 0.000667790166179422 0.00214318097672708 0.999807790876473 0.99943838714673 0.999960360103688 0.8125 0.543543453768388 0.959526266094054 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.64756889850375 0.280674269522998 269 2512 False False 6.53033961049412 1.79379356915147 35.7259831225824 0 0 0.000356177930119202 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 9 2 7727 11872 0.00116339193381592 0.000532110502771461 0.00220732634615895 0.999831564763348 0.99939168785815 0.999979601060482 0.818181818181818 0.482244147639827 0.97716880170004 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.18226240554264 0.522356741482369 466 2071 False False 0 0 0 0 0 0 0 6.91393813899314 1.43038623489484 65.8449988812258 0 0 0.00047728731155563 0.999831564763348 0.99939168785815 0.999979601060482 54 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 p.Arg81His whiB7_p.Arg81His 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1548 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1273 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance No change no 1 +Streptomycin whiB7 p.Arg87Cys whiB7_p.Arg87Cys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1545 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin whiB7 p.Asp24His whiB7_p.Asp24His 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 4 10368 15604 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 0 0 0.602364635616474 0 0 0.841886116991581 0 0 0.602364635616474 0 0 8.01462049278838 0.520315555582948 435.5 2512 False False 0 0 2.28044779470556 0 0 0.000355731413006942 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 3 7736 11871 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 0 0 0.707598226178713 0 0 0.841886116991581 0 0 0.707598226178713 0 0 8.17205443383047 0.522230766108178 361 2071 False False 0 0 0 0 0 0 0 0 0 3.71438150990605 0 0 0.000476732171726368 0.999747347145022 0.999261820436506 0.999947893876346 14 3) Uncertain significance No change no 1 +Streptomycin whiB7 p.Asp26Gly whiB7_p.Asp26Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1549 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1274 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance No change no 1 +Streptomycin whiB7 p.Cys20Tyr whiB7_p.Cys20Tyr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1461 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1201 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance No change no 1 +Streptomycin whiB7 p.Gln13Lys whiB7_p.Gln13Lys 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1471 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1209 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 p.Gln58Arg whiB7_p.Gln58Arg 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 11 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 p.Gln58His whiB7_p.Gln58His 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1522 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin whiB7 p.Glu69Lys whiB7_p.Glu69Lys 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1519 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin whiB7 p.Gly23Asp whiB7_p.Gly23Asp 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 1 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0386035211949905 Inf 0.399114533205004 308.5 2512 False False Inf 0.282736080598822 Inf 9.64599209028648e-05 2.44215077354346e-06 0.000537321795461189 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 1 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 1 0.025 1 1 0.025 1 Inf 0.0393613144801391 Inf 0.394461726758121 237.5 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0.000129282482223658 3.27314370392442e-06 0.000720103058325324 1 0.999689379610589 1 1 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 p.Gly64fs whiB7_p.Gly64fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 47 441 10321 15167 0.00453317901234567 0.00333265407962654 0.00602365841767622 0.971745258841619 0.969024124980124 0.974288609346293 0.096311475409836 0.0716260956205053 0.126012994882561 NA NA NA 0 0 0.00832991837243668 NA NA NA NA 1533 2512 False True 0.156616378424896 0.113244703408007 0.21211833678968 0 0 0.000357351061172118 0.971745258841619 0.969024124980124 0.974288609346293 5) Not assoc w R 5) Not assoc w R WHO 5) Not assoc w R 0 0 0 0 44 421 7692 11453 0.00568769389865563 0.00413563892296155 0.00762802222491731 0.964544382684857 0.961060131121389 0.967798417815616 0.0946236559139784 0.0695968980988016 0.124943933198714 NA NA NA 0 0 0.00872390791803612 NA NA NA NA 1262 2071 False True 0 1 1 0 0 0 0 0.155614680644232 0.111237428705167 0.212908782217962 0 0 0.000479458534979305 0.964544382684857 0.961060131121389 0.967798417815616 428 5) Not assoc w R New NotAwR yes 5 +Streptomycin whiB7 p.Gly67Val whiB7_p.Gly67Val 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 11 0 10357 15608 0.00106095679012345 0.000529741017552837 0.00189754996565939 1 0.99976368249849 1 1 0.715085847081845 1 NA NA NA NA NA NA NA NA NA NA 1546 2512 False False Inf 3.78113295637047 Inf 0 0 0.000356109162232076 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 11 0 7725 11874 0.0014219234746639 0.000710026047388019 0.00254278626393864 1 0.999689379610589 1 1 0.715085847081845 1 NA NA NA NA NA NA NA NA NA NA 1272 2071 False False 0 0 0 0 0 0 0 Inf 3.85616586380724 Inf 0 0 0.000477410851584718 1 0.999689379610589 1 2 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 p.Gly84_Arg87del whiB7_p.Gly84_Arg87del 1 inframe_deletion (see "Genomic_coordinates" sheet) 1 12 0 12 18 21 10350 15587 0.00173611111111111 0.00102924387949825 0.00274242148457404 0.998654536135315 0.997944046996364 0.999166949785744 0.461538461538461 0.300947803007507 0.628189252793481 0 0 0.264648469397051 0 0 0.161097615219079 0 0 0.542132276774869 0.00253175478429515 49 2512 False False 1.29084886128364 0.647981210187516 2.54588254511195 0 0 0.000356349966090498 0.998654536135315 0.997944046996364 0.999166949785744 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 8 0 8 16 16 7720 11858 0.00206825232678386 0.00118263260320744 0.00335654494667737 0.998652518106788 0.997812693726175 0.999229607694274 0.5 0.318874964234163 0.681125035765836 0 0 0.369416647552819 0 0 0.205907214207822 0 0 0.900190991399851 0.0258687698655936 70 2071 False False 0 0 0 0 0 0 0 1.5360103626943 0.71859222824397 3.28290217377948 0 0 0.000477719981635933 0.998652518106788 0.997812693726175 0.999229607694274 24 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 p.His79fs whiB7_p.His79fs 1 frameshift (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1472 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1210 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 p.His79Gln whiB7_p.His79Gln 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 14 0 10354 15608 0.0013503086419753 0.00073841672613154 0.00226455162408295 1 0.99976368249849 1 1 0.768364238349883 1 NA NA NA NA NA NA NA NA NA NA 1467 2512 False False Inf 4.9982004654745 Inf 0 0 0.000356212324023499 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 9 0 7727 11874 0.00116339193381592 0.000532110502771461 0.00220732634615895 1 0.999689379610589 1 1 0.663732883120057 1 NA NA NA NA NA NA NA NA NA NA 1205 2071 False False 0 0 0 0 0 0 0 Inf 3.03189582764095 Inf 0 0 0.00047728731155563 1 0.999689379610589 1 64 3) Uncertain significance No change no 1 +Streptomycin whiB7 p.Ile70Thr whiB7_p.Ile70Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1477 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1215 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 p.Leu18Phe whiB7_p.Leu18Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1473 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1211 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 1 3) Uncertain significance No change no 1 +Streptomycin whiB7 p.Leu27Pro whiB7_p.Leu27Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1475 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1213 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 p.Leu36Phe whiB7_p.Leu36Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance No change no 1 +Streptomycin whiB7 p.Leu42fs whiB7_p.Leu42fs 1 frameshift (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1506 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1239 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin whiB7 p.Leu42Pro whiB7_p.Leu42Pro 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 8 0 10360 15608 0.000771604938271604 0.00033318123262376 0.00151980017311994 1 0.99976368249849 1 1 0.63058335244718 1 NA NA NA NA NA NA NA NA NA NA 1512 2512 False False Inf 2.57069745416703 Inf 0 0 0.000356006060176228 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 6 0 7730 11874 0.00077559462254395 0.000284681048736677 0.00168737281383633 1 0.999689379610589 1 1 0.540741873560099 1 NA NA NA NA NA NA NA NA NA NA 1245 2071 False False 0 0 0 0 0 0 0 Inf 1.80798545886233 Inf 0 0 0.000477102121347592 1 0.999689379610589 1 54 3) Uncertain significance No change no 1 +Streptomycin whiB7 p.Leu57Phe whiB7_p.Leu57Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1516 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1249 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 2 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 p.Lys40Asn whiB7_p.Lys40Asn 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1534 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 1 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 p.Lys80Gln whiB7_p.Lys80Gln 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 14 0 10354 15608 0.0013503086419753 0.00073841672613154 0.00226455162408295 1 0.99976368249849 1 1 0.768364238349883 1 NA NA NA NA NA NA NA NA NA NA 1494 2512 False False Inf 4.9982004654745 Inf 0 0 0.000356212324023499 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 9 0 7727 11874 0.00116339193381592 0.000532110502771461 0.00220732634615895 1 0.999689379610589 1 1 0.663732883120057 1 NA NA NA NA NA NA NA NA NA NA 1229 2071 False False 0 0 0 0 0 0 0 Inf 3.03189582764095 Inf 0 0 0.00047728731155563 1 0.999689379610589 1 64 3) Uncertain significance No change no 1 +Streptomycin whiB7 p.Lys88Thr whiB7_p.Lys88Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 3 0 3 1 3 10367 15605 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999807790876473 0.99943838714673 0.999960360103688 0.25 0.00630946320970987 0.805879550316756 0 0 0.707598226178713 0 0 0.707598226178713 0 0 3.64334605529666 0.280505932748473 259.5 2512 False False 0.501752355229735 0.00956153582768186 6.25014259670444 0 0 0.000355765720726338 0.999807790876473 0.99943838714673 0.999960360103688 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 59.8138891519084 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin whiB7 p.Met1? whiB7_p.Met1? 1 start_lost (see "Genomic_coordinates" sheet) 0 0 0 0 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 NA NA NA 0 0 0.975 NA NA NA NA 1462 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1202 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 p.Phe29Ser whiB7_p.Phe29Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1463 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1203 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance No change no 1 +Streptomycin whiB7 p.Pro11fs whiB7_p.Pro11fs 1 frameshift (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 3 3) Uncertain significance No change no 1 +Streptomycin whiB7 p.Pro11Ser whiB7_p.Pro11Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 4 10366 15604 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 0.999743721168631 0.999343955596995 0.999930168370675 0.333333333333333 0.0432718682927417 0.777221904496487 NA NA NA 0 0 0.602364635616474 NA NA NA NA 1490 2512 False False 0.752652903723712 0.0680519547847045 5.25297485318028 0 0 0.000355800035063835 0.999743721168631 0.999343955596995 0.999930168370675 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 NA NA NA 0 0 0.841886116991581 NA NA NA NA 1226 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 11 3) Uncertain significance No change no 1 +Streptomycin whiB7 p.Pro25Leu whiB7_p.Pro25Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 58.6540000158548 1 973.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.975 0 0 0.841886116991581 0 0 59.801132462225 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 p.Pro33Ser whiB7_p.Pro33Ser 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1493 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 p.Pro33Thr whiB7_p.Pro33Thr 1 missense_variant (see "Genomic_coordinates" sheet) 1 2 0 2 0 2 10368 15606 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.01564764707657 0.520327955056166 495.5 2512 False False 0 0 8.01564764707657 0 0 0.000355731413006942 0.999871860584315 0.999537193839207 0.999984481345552 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 2 0 2 0 2 7736 11872 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 0 0 0.841886116991581 0 0 0.841886116991581 0 0 0.841886116991581 0 0 8.17274275317631 0.522239257338177 407.5 2071 False False 0 0 0 0 0 0 0 0 0 8.17274275317631 0 0 0.000476732171726368 0.999831564763348 0.99939168785815 0.999979601060482 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 p.Pro47Leu whiB7_p.Pro47Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA NA 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 p.Pro62Thr whiB7_p.Pro62Thr 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1523 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1253 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 1 3) Uncertain significance No change no 1 +Streptomycin whiB7 p.Pro7Arg whiB7_p.Pro7Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1498 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1231 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 p.Pro7Leu whiB7_p.Pro7Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 p.Pro82Leu whiB7_p.Pro82Leu 1 missense_variant (see "Genomic_coordinates" sheet) 2 1 0 1 1 1 10367 15607 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 0.999935930292158 0.99964307871082 0.999998377896754 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 58.6634076928655 1 973.5 2512 False False 1.50544998553101 0.0191837380556942 118.074698097101 0 0 0.000355765720726338 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 2 1 0 1 1 1 7735 11873 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 0.999915782381674 0.999530859783396 0.999997867796783 0.5 0.012579117093425 0.987420882906574 0 0 0.975 0 0 0.975 0 0 59.8138891519084 1 806.5 2071 False False 0 0 0 0 0 0 0 1.53497091144149 0.0195519049186736 120.390152361053 0 0 0.000476793790149404 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 p.Ser2Ala whiB7_p.Ser2Ala 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1478 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0 0 0 0 0 0 0 NA NA NA NA NA NA NA NA NA 2 3) Uncertain significance No change no 1 +Streptomycin whiB7 p.Ser45Arg whiB7_p.Ser45Arg 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1468 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1206 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 1 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 p.Ser45Gly whiB7_p.Ser45Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1474 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1212 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 p.Thr32Asn whiB7_p.Thr32Asn 1 missense_variant (see "Genomic_coordinates" sheet) 1 0 0 0 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1538 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 0 0 0 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 NA NA NA 0 0 0.975 NA NA NA NA 1266 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 1 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 p.Trp28* whiB7_p.Trp28* 1 stop_gained (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1513 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1246 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 p.Val38Leu whiB7_p.Val38Leu 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance No change no 1 +Streptomycin whiB7 p.Val65fs whiB7_p.Val65fs 1 frameshift (see "Genomic_coordinates" sheet) 1 1 0 1 3 1 10365 15607 0.000289351851851851 5.96752836124556e-05 0.000845373740077563 0.999935930292158 0.99964307871082 0.999998377896754 0.75 0.194120449683243 0.99369053679029 0 0 0.975 0 0 0.975 0 0 58.6747168343076 1 610 2512 False False 4.51722141823444 0.362625225225282 236.854590713406 0 0 0.000355834356021348 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 2 1 7734 11873 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 0.999915782381674 0.999530859783396 0.999997867796783 0.666666666666666 0.0942993240502461 0.991596241340387 0 0 0.975 0 0 0.975 0 0 59.821615810862 1 806.5 2071 False False 0 0 0 0 0 0 0 3.07033876389966 0.159799628612092 180.959738606129 0 0 0.000476855424503066 0.999915782381674 0.999530859783396 0.999997867796783 15 3) Uncertain significance No change no 1 +Streptomycin whiB7 p.Val65Phe whiB7_p.Val65Phe 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 1 0 10367 15608 9.64506172839506e-05 2.44191522688145e-06 0.000537269981867773 1 0.99976368249849 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1499 2512 False False Inf 0.0385997978146249 Inf 0 0 0.000355765720726338 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 1 0 7735 11874 0.000129265770423991 3.27272059917417e-06 0.000720010001152035 1 0.999689379610589 1 1 0.025 1 NA NA NA NA NA NA NA NA NA NA 1232 2071 False False 0 0 0 0 0 0 0 Inf 0.0393562263478767 Inf 0 0 0.000476793790149404 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 p.Val6Phe whiB7_p.Val6Phe 1 missense_variant (see "Genomic_coordinates" sheet) 1 1 0 1 0 1 10368 15607 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 0 0 0.975 0 0 0.975 0 0 0.975 0 0 58.6577547568054 1 973.5 2512 False False 0 0 58.6577547568054 0 0 0.000355731413006942 0.999935930292158 0.99964307871082 0.999998377896754 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 1 1 0 1 0 1 7736 11873 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 0 0 0.975 0 0 0.975 0 0 0.975 0 0 59.8061644886732 1 806.5 2071 False False 0 0 0 0 0 0 0 0 0 59.8061644886732 0 0 0.000476732171726368 0.999915782381674 0.999530859783396 0.999997867796783 NA 3) Uncertain significance New Uncertain no 0 +Streptomycin whiB7 p.Val91Gly whiB7_p.Val91Gly 1 missense_variant (see "Genomic_coordinates" sheet) 0 0 0 0 2 0 10366 15608 0.000192901234567901 2.33620882160693e-05 0.000696650033648562 1 0.99976368249849 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1514 2512 False False Inf 0.282736080598822 Inf 0 0 0.000355800035063835 1 0.99976368249849 1 3) Uncertain significance 3) Uncertain significance ALL+WHO 3) Uncertain significance 0 0 0 0 2 0 7734 11874 0.000258531540847983 3.13109026146236e-05 0.000933589503470527 1 0.999689379610589 1 1 0.158113883008419 1 NA NA NA NA NA NA NA NA NA NA 1247 2071 False False 0 0 0 0 0 0 0 Inf 0.288279755767314 Inf 0 0 0.000476855424503066 1 0.999689379610589 1 NA 3) Uncertain significance New Uncertain no 0 diff --git a/bin/adjust_tbprofiler_resistance_predictions.py b/bin/adjust_tbprofiler_resistance_predictions.py new file mode 100755 index 0000000..5f520f7 --- /dev/null +++ b/bin/adjust_tbprofiler_resistance_predictions.py @@ -0,0 +1,714 @@ +#!/usr/bin/env python3 + + +import argparse +import csv +import json +import logging +import sys + +from pathlib import Path + + +def parse_tbprofiler_full_report(input_file: Path) -> dict: + """ + Parse the tbprofiler full report file + + :param input_file: The input tbprofiler full report file (json) + :type input_file: str + :return: The parsed tbprofiler full report + :rtype: dict + """ + tbprofiler_full_report = {} + with open(input_file, 'r') as f: + tbprofiler_full_report = json.load(f) + return tbprofiler_full_report + + +def parse_tbprofiler_resistance_predictions(input_file: Path) -> dict: + """ + Parse the tbprofiler resistance predictions file + + :param input_file: The input tbprofiler resistance predictions file (csv) + :type input_file: str + :return: The parsed tbprofiler resistance predictions + :rtype: dict + """ + tbprofiler_resistance_prediction_by_drug = {} + with open(input_file, 'r') as f: + reader = csv.DictReader(f) + for row in reader: + drug = row['drug'] + if drug not in tbprofiler_resistance_prediction_by_drug: + tbprofiler_resistance_prediction_by_drug[drug] = row + + return tbprofiler_resistance_prediction_by_drug + + +def parse_tbprofiler_resistance_mutations(input_file: Path) -> dict: + """ + Parse the tbprofiler resistance mutations file + + :param input_file: The input tbprofiler resistance mutations file (csv) + :type input_file: str + :return: The parsed tbprofiler resistance mutations + :rtype: dict + """ + tbprofiler_resistance_mutations_by_drug = {} + float_fields = [ + 'estimated_fraction', + ] + with open(input_file, 'r') as f: + reader = csv.DictReader(f) + for row in reader: + if row['drug'] not in tbprofiler_resistance_mutations_by_drug: + tbprofiler_resistance_mutations_by_drug[row['drug']] = [] + for field in float_fields: + if row[field] == '': + row[field] = None + else: + row[field] = float(row[field]) + if row['mutation'] != '': + mutation = { + 'gene': row['gene'], + 'mutation': row['mutation'], + 'estimated_fraction': row['estimated_fraction'], + } + tbprofiler_resistance_mutations_by_drug[row['drug']].append(mutation) + + return tbprofiler_resistance_mutations_by_drug + + +def parse_mutation_catalogue(catalogue_path): + """ + Parse the WHO TB mutation catalogue. + + :param catalogue_path: Path to the WHO TB mutation catalogue + :type catalogue_path: str + :return: The parsed mutation catalogue + :rtype: list + """ + fieldname_translation = { + 'initial_confidence_grading_all_dataset_dataset_all': 'initial_confidence_grading_dataset_all', + 'initial_confidence_grading_who_dataset_dataset_who': 'initial_confidence_grading_dataset_who', + 'relaxed_thresholds_simulation_bdq_rv0678,_cfz_rv0678,_inh_katg,_dlm_ddn/fbia/fbib/fbic/fgd1/rv2983': 'relaxed_thresholds_simulation', + 'who_guidance_before_cat_ver1_miotto_et_al._pmid_29284687,_who_ngs_guide_2018_source_of_additional_grading_evidence': 'who_guidance_before_cat_ver1_from_miotto_et_al_pmid_29284687', + 'who_guidance_before_cat_ver1_rif_cc_guide_2021_source_of_additional_grading_evidence': 'who_guidance_before_cat_ver1_rif_cc_guide_2021', + } + + lowercase_fields = [ + 'drug', + ] + + int_fields = [ + 'tier', + 'algorithm_pass_dataset_all', + 'present_solo_sr_dataset_all', + 'present_solo_r_dataset_all', + 'present_solo_s_dataset_all', + 'present_r_dataset_all', + 'present_s_dataset_all', + 'absent_r_dataset_all', + 'absent_s_dataset_all', + 'seta_dataset_who', + 'setb_dataset_who', + 'setc_dataset_who', + 'setd1_dataset_who', + 'setd2_dataset_who', + 'v1_dataset_who', + 'literature_dataset_who', + 'algorithm_pass_dataset_who', + 'present_solo_sr_dataset_who', + 'present_solo_r_dataset_who', + 'present_solo_s_dataset_who', + 'present_r_dataset_who', + 'present_s_dataset_who', + 'absent_r_dataset_who', + 'absent_s_dataset_who', + 'present_nopheno_no_pdst', + 'changes_vs_ver1', + ] + + float_fields = [ + 'sens_dataset_all', + 'sens_lb_dataset_all', + 'sens_ub_dataset_all', + 'sens_dataset_who', + 'sens_lb_dataset_who', + 'sens_ub_dataset_who', + 'spec_dataset_all', + 'spec_lb_dataset_all', + 'spec_ub_dataset_all', + 'spec_dataset_who', + 'spec_lb_dataset_who', + 'spec_ub_dataset_who', + 'ppv_dataset_all', + 'ppv_lb_dataset_all', + 'ppv_ub_dataset_all', + 'ppv_dataset_who', + 'ppv_lb_dataset_who', + 'ppv_ub_dataset_who', + 'ppv_solo_dataset_all', + 'ppv_solo_lb_dataset_all', + 'ppv_solo_ub_dataset_all', + 'ppv_solo_dataset_who', + 'ppv_solo_lb_dataset_who', + 'ppv_solo_ub_dataset_who', + 'ppv_conditional_solo_dataset_all', + 'ppv_conditional_solo_lb_dataset_all', + 'ppv_conditional_solo_ub_dataset_all', + 'ppv_conditional_solo_dataset_who', + 'ppv_conditional_solo_lb_dataset_who', + 'ppv_conditional_solo_ub_dataset_who', + 'or_solo_dataset_all', + 'or_solo_exact_lb_dataset_all', + 'or_solo_exact_ub_dataset_all', + 'or_solo_pvalue_dataset_all', + 'or_solo_pval_rank_dataset_all', + 'or_solo_dataset_who', + 'or_solo_exact_lb_dataset_who', + 'or_solo_exact_ub_dataset_who', + 'or_solo_pvalue_dataset_who', + 'or_solo_pval_rank_dataset_who', + 'k_dataset_all', + 'k_dataset_who', + 'or_solo_fe_sig_dataset_all', + 'neutral_masked_dataset_all', + 'or_dataset_all', + 'or_exact_lb_dataset_all', + 'or_exact_ub_dataset_all', + 'or_dataset_who', + 'or_exact_lb_dataset_who', + 'or_exact_ub_dataset_who', + 'sens_solo_dataset_all', + 'sens_solo_lb_dataset_all', + 'sens_solo_ub_dataset_all', + 'sens_solo_dataset_who', + 'sens_solo_lb_dataset_who', + 'sens_solo_ub_dataset_who', + 'spec_solo_dataset_all', + 'spec_solo_lb_dataset_all', + 'spec_solo_ub_dataset_all', + 'spec_solo_dataset_who', + 'spec_solo_lb_dataset_who', + 'spec_solo_ub_dataset_who', + ] + + percent_fields = [ + 'ppv', + 'ppv_lb', + 'ppv_ub', + ] + + boolean_fields = [ + 'or_solo_fe_sig_dataset_all', + 'or_solo_fe_sig_dataset_who', + 'neutral_masked_dataset_all', + 'neutral_masked_dataset_who', + ] + + yes_no_fields = [ + 'listed_in_abridged_tables', + ] + + silent_mutation_fields = [ + 'silent_mutation', + ] + + grading_fields = [ + 'initial_confidence_grading', + 'initial_confidence_grading_dataset_all', + 'initial_confidence_grading_dataset_who', + 'final_confidence_grading', + ] + + catalogue = [] + + with open(catalogue_path, 'r') as f: + reader = csv.DictReader(f, delimiter='\t') + for row in reader: + parsed_record = {} + for k in row.keys(): + cleaned_key = k.lower().replace(' ', '_').replace('(', '').replace(')', '').replace('_|_', '_') + if cleaned_key in fieldname_translation: + cleaned_key = fieldname_translation[cleaned_key] + + if cleaned_key in lowercase_fields: + row[k] = row[k].lower() + elif cleaned_key in int_fields: + try: + row[k] = int(row[k]) + except ValueError as e: + row[k] = None + elif cleaned_key in float_fields: + try: + row[k] = float(row[k]) + except ValueError as e: + row[k] = None + elif cleaned_key in percent_fields: + try: + row[k] = float(row[k].rstrip('%')) + except ValueError as e: + row[k] = None + elif cleaned_key in boolean_fields: + try: + row[k] = row[k].lower() == 'true' + except ValueError as e: + row[k] = None + elif cleaned_key in yes_no_fields: + try: + row[k] = row[k].lower() == 'yes' + except ValueError as e: + row[k] = None + elif cleaned_key in silent_mutation_fields: + try: + row[k] = row[k].lower() == 'silent mutation' + except ValueError as e: + row[k] = None + elif cleaned_key in grading_fields: + try: + grading_level = int(row[k].split(')')[0]) + grading_category = row[k].split(')')[1].strip() + if 'Interim' in grading_category: + interim_grading = True + else: + interim_grading = False + if 'Assoc w R' in grading_category: + associated_with_resistance = True + else: + associated_with_resistance = False + except ValueError as e: + grading_number = None + grading_category = None + interim_grading = None + row[k] = { + 'original_value': row[k], + 'level': grading_level, + 'category': grading_category, + 'interim_grading': interim_grading, + 'associated_with_resistance': associated_with_resistance, + } + + parsed_record[cleaned_key] = row[k] + + # The 'genomic_position' field is always "(see \"Genomic_coordinates\" sheet)" + parsed_record.pop('genomic_position', None) + + catalogue.append(parsed_record) + + return catalogue + + +def index_mutation_catalogue_by_mutation_by_gene_by_drug(mutation_catalogue): + """ + Index the mutation catalogue by mutation, gene, and drug + + :param mutation_catalogue: The mutation catalogue + :type mutation_catalogue: list + :return: The indexed mutation catalogue. Nested by drug, gene, and mutation. + :rtype: dict + """ + catalogue_by_mutation_by_gene_by_drug = {} + for record in mutation_catalogue: + mutation = record['mutation'] + gene = record['gene'] + drug = record['drug'] + if drug not in catalogue_by_mutation_by_gene_by_drug: + catalogue_by_mutation_by_gene_by_drug[drug] = {} + if gene not in catalogue_by_mutation_by_gene_by_drug[drug]: + catalogue_by_mutation_by_gene_by_drug[drug][gene] = {} + catalogue_by_mutation_by_gene_by_drug[drug][gene][mutation] = record + + return catalogue_by_mutation_by_gene_by_drug + + +def index_full_report_resistance_variants_by_mutation_by_gene_by_drug(tbprofiler_full_report_resistance_variants): + """ + Index the full report resistance variants by mutation, gene, and drug + + :param tbprofiler_full_report_resistance_variants: The full report resistance variants + :type tbprofiler_full_report_resistance_variants: list + :return: The indexed full report resistance variants. Nested by drug, gene, and mutation. + :rtype: dict + """ + full_report_resistance_variants_by_mutation_by_gene_by_drug = {} + for variant in tbprofiler_full_report_resistance_variants: + mutation = variant['change'] + gene = variant['gene_name'] + drugs = [] + for annotation in variant['annotation']: + if annotation['type'] == 'drug_resistance' or annotation['type'] == 'who_confidence': + drugs.append(annotation['drug']) + if len(drugs) == 0: + continue + for drug in drugs: + if drug not in full_report_resistance_variants_by_mutation_by_gene_by_drug: + full_report_resistance_variants_by_mutation_by_gene_by_drug[drug] = {} + if gene not in full_report_resistance_variants_by_mutation_by_gene_by_drug[drug]: + full_report_resistance_variants_by_mutation_by_gene_by_drug[drug][gene] = {} + full_report_resistance_variants_by_mutation_by_gene_by_drug[drug][gene][mutation] = variant + + return full_report_resistance_variants_by_mutation_by_gene_by_drug + + +def parse_drug_ppv_thresholds(input_file: Path) -> dict: + """ + Parse the drug PPV thresholds file. The file should be a CSV with the following columns: + - drug + - ppv_threshold + + :param input_file: The input drug PPV thresholds file (csv) + :type input_file: str + :return: The parsed drug PPV thresholds + :rtype: dict + """ + drug_ppv_thresholds = {} + + with open(input_file, 'r') as f: + reader = csv.DictReader(f) + for row in reader: + drug = row['drug'] + try: + ppv_threshold = float(row['ppv_threshold']) + except ValueError as e: + continue + drug_ppv_thresholds[drug] = ppv_threshold + + return drug_ppv_thresholds + + +def combined_resistance_probability(mutations): + """ + Calculate the combined resistance probability given a list of PPVs + + :param ppvs: The list of PPVs + :type ppvs: list + :return: The combined resistance probability + :rtype: float + """ + + combined_prob = 1 + for mutation in mutations: + if 'ppv' not in mutation: + continue + ppv = mutation['ppv'] + combined_prob *= (1 - ppv) + combined_prob = 1 - combined_prob + + return combined_prob + + +def collect_catalogue_info_for_mutation(tbprofiler_resistance_mutation_record, indexed_catalogue, drug): + """ + Collect information from the mutation catalogue for a given mutation + + :param mutation: The mutation + :type mutation: dict + :param indexed_catalogue: The indexed mutation catalogue + :type indexed_catalogue: dict + :param drug: The drug name to look up in the indexed mutation catalogue + :type drug: str + :return: The mutation with additional information from the mutation catalogue + """ + gene = tbprofiler_resistance_mutation_record.get('gene', None) + if gene is None or gene not in indexed_catalogue[drug]: + logging.warning(f"Gene {gene} not found in mutation catalogue for drug {drug}") + + return tbprofiler_resistance_mutation_record + + mutation = tbprofiler_resistance_mutation_record.get('mutation', None) + if mutation is None or mutation not in indexed_catalogue[drug][gene]: + logging.warning(f"Mutation {mutation} not found in mutation catalogue for gene {gene} and drug {drug}") + + return tbprofiler_resistance_mutation_record + + + mutation_catalogue_record = indexed_catalogue[drug][gene][mutation] + catalogue_dataset = "all" + tbprofiler_resistance_mutation_record['catalogue_ppv_estimate'] = mutation_catalogue_record.get('ppv_dataset_all', None) + tbprofiler_resistance_mutation_record['catalogue_ppv_lower_bound'] = mutation_catalogue_record.get('ppv_lb_dataset_all', None) + tbprofiler_resistance_mutation_record['catalogue_ppv_upper_bound'] = mutation_catalogue_record.get('ppv_ub_dataset_all', None) + tbprofiler_resistance_mutation_record['catalogue_dataset'] = catalogue_dataset + tbprofiler_resistance_mutation_record['catalogue_final_confidence_grading'] = mutation_catalogue_record.get('final_confidence_grading', {}).get('category', None) + + #print(json.dumps(tbprofiler_resistance_mutation_record, indent=2)) + #exit() + + return tbprofiler_resistance_mutation_record + + +def collect_full_report_info_for_resistance_mutation(tbprofiler_resistance_mutation_record, indexed_tbprofiler_full_report_resistance_variants, drug): + """ + Collect information from the full report for a given mutation + + :param tbprofiler_resistance_mutation_record: The mutation + :type tbprofiler_resistance_mutation_record: dict + :param indexed_tbprofiler_full_report_resistance_variants: The indexed full report resistance variants + :type indexed_tbprofiler_full_report_resistance_variants: dict + :param drug: The drug name to look up in the indexed full report resistance variants + :type drug: str + :return: The mutation with additional information from the full report + :rtype: dict + """ + gene = tbprofiler_resistance_mutation_record.get('gene', None) + if gene not in indexed_tbprofiler_full_report_resistance_variants[drug]: + logging.warning(f"Gene {gene} not found in full report resistance variants for drug {drug}") + return tbprofiler_resistance_mutation_record + + mutation = tbprofiler_resistance_mutation_record.get('mutation', None) + if mutation not in indexed_tbprofiler_full_report_resistance_variants[drug][gene]: + logging.warning(f"Mutation {mutation} not found in full report resistance variants for gene {gene} and drug {drug}") + return tbprofiler_resistance_mutation_record + + full_report_variant = indexed_tbprofiler_full_report_resistance_variants[drug][gene][mutation] + # print(json.dumps(full_report_variant, indent=2)) + # exit() + + for annotation in full_report_variant['annotation']: + if annotation['type'] == 'drug_resistance' or annotation['type'] == 'who_confidence': + if annotation['drug'] == drug: + tbprofiler_resistance_mutation_record['drug'] = drug + tbprofiler_resistance_mutation_record['ref_genome_accession'] = "NC_000962.3" + tbprofiler_resistance_mutation_record['position'] = full_report_variant.get('pos', None) + tbprofiler_resistance_mutation_record['ref_allele'] = full_report_variant.get('ref', None) + tbprofiler_resistance_mutation_record['alt_allele'] = full_report_variant.get('alt', None) + tbprofiler_resistance_mutation_record['depth'] = full_report_variant.get('depth', None) + tbprofiler_resistance_mutation_record['alt_freq'] = full_report_variant.get('freq', None) + tbprofiler_resistance_mutation_record['tbprofiler_filter'] = full_report_variant.get('filter', None) + tbprofiler_resistance_mutation_record['mutation_type'] = full_report_variant.get('type', None) + tbprofiler_resistance_mutation_record['tbprofiler_confidence'] = annotation.get('confidence', None) + tbprofiler_resistance_mutation_record['tbprofiler_source'] = annotation.get('source', None) + break + + return tbprofiler_resistance_mutation_record + + +def format_full_report_info_for_other_variant(tbprofiler_full_report_other_variant): + """ + Collect and format relevant information from the full report for a given 'other' variant + + :param tbprofiler_full_report_other_variant: The variant + :type tbprofiler_full_report_other_variant: dict + :return: The variant with additional information from the full report, indexed by drug + :rtype: dict + """ + formatted_variant_by_drug = {} + drugs = [] + for annotation in tbprofiler_full_report_other_variant['annotation']: + if annotation['type'] == 'drug_resistance' or annotation['type'] == 'who_confidence': + drug = annotation.get('drug', None) + if drug is not None: + drugs.append(drug) + confidence = annotation.get('confidence', None) + source = annotation.get('source', None) + formatted_variant_by_drug[drug] = { + 'drug': drug, + 'tbprofiler_confidence': confidence, + 'tbprofiler_source': source, + } + + if len(drugs) == 0: + return formatted_variant_by_drug + + for drug in drugs: + formatted_variant = formatted_variant_by_drug[drug] + formatted_variant['drug'] = drug + formatted_variant['ref_genome_accession'] = "NC_000962.3" + formatted_variant['gene'] = tbprofiler_full_report_other_variant.get('gene_name', None) + formatted_variant['mutation'] = tbprofiler_full_report_other_variant.get('change', None) + formatted_variant['position'] = tbprofiler_full_report_other_variant.get('pos', None) + formatted_variant['ref_allele'] = tbprofiler_full_report_other_variant.get('ref', None) + formatted_variant['alt_allele'] = tbprofiler_full_report_other_variant.get('alt', None) + formatted_variant['depth'] = tbprofiler_full_report_other_variant.get('depth', None) + formatted_variant['alt_freq'] = tbprofiler_full_report_other_variant.get('freq', None) + formatted_variant['tbprofiler_filter'] = tbprofiler_full_report_other_variant.get('filter', None) + formatted_variant['mutation_type'] = tbprofiler_full_report_other_variant.get('type', None) + + return formatted_variant_by_drug + + +def main(args): + + log_format = '%(asctime)s - %(name)s - %(levelname)s - %(message)s' + logging.basicConfig(level=logging.INFO, format=log_format) + + mutation_catalogue = parse_mutation_catalogue(args.input_who_mutation_catalogue) + # print(json.dumps(mutation_catalogue[0:10], indent=2)) + # exit() + + indexed_catalogue = index_mutation_catalogue_by_mutation_by_gene_by_drug(mutation_catalogue) + + tbprofiler_resistance_mutations_by_drug = parse_tbprofiler_resistance_mutations(args.input_tbprofiler_resistance_mutations) + + # print(json.dumps(tbprofiler_resistance_mutations_by_drug, indent=2)) + # exit() + + tbprofiler_resistance_prediction_by_drug = parse_tbprofiler_resistance_predictions(args.input_tbprofiler_resistance_predictions) + # print(json.dumps(tbprofiler_resistance_prediction_by_drug, indent=2)) + # exit() + + tbprofiler_full_report = parse_tbprofiler_full_report(args.input_tbprofiler_full_report) + # print(json.dumps(tbprofiler_full_report, indent=2)) + # exit() + + tbprofiler_full_report_resistance_variants = tbprofiler_full_report.get('dr_variants', []) + + # Index resistance variants ("dr_variants") from tbprofiler full json report by drug, gene, and mutation + indexed_tbprofiler_full_report_resistance_variants = index_full_report_resistance_variants_by_mutation_by_gene_by_drug(tbprofiler_full_report_resistance_variants) + + # Index other variants ("other_variants") from tbprofiler full json report by drug, gene, and mutation + indexed_tbprofiler_full_report_other_variants = {} + tbprofiler_full_report_other_variants = tbprofiler_full_report.get('other_variants', []) + for variant in tbprofiler_full_report_other_variants: + formatted_variant_by_drug = format_full_report_info_for_other_variant(variant) + for drug, formatted_variant in formatted_variant_by_drug.items(): + if drug not in indexed_tbprofiler_full_report_other_variants: + indexed_tbprofiler_full_report_other_variants[drug] = {} + gene = formatted_variant['gene'] + if gene not in indexed_tbprofiler_full_report_other_variants[drug]: + indexed_tbprofiler_full_report_other_variants[drug][gene] = {} + mutation = formatted_variant['mutation'] + formatted_variant = collect_catalogue_info_for_mutation(formatted_variant, indexed_catalogue, drug) + indexed_tbprofiler_full_report_other_variants[drug][gene][mutation] = formatted_variant + + tbprofiler_other_variants_by_drug = {} + for drug, variants_by_gene in indexed_tbprofiler_full_report_other_variants.items(): + for gene, variants in variants_by_gene.items(): + for mutation, variant in variants.items(): + if drug not in tbprofiler_other_variants_by_drug: + tbprofiler_other_variants_by_drug[drug] = [] + tbprofiler_other_variants_by_drug[drug].append(variant) + + + + drug_ppv_thresholds = {} + if args.drug_ppv_thresholds: + drug_ppv_thresholds = parse_drug_ppv_thresholds(args.drug_ppv_thresholds) + + for drug, tbprofiler_resistance_mutations in tbprofiler_resistance_mutations_by_drug.items(): + drug = drug.lower() + if drug not in indexed_catalogue: + logging.warning(f"Drug {drug} not found in mutation catalogue") + continue + for idx, tbprofiler_resistance_mutation in enumerate(tbprofiler_resistance_mutations): + resistance_mutation_with_catalogue_info = collect_catalogue_info_for_mutation(tbprofiler_resistance_mutation, indexed_catalogue, drug) + tbprofiler_resistance_mutations[idx] = resistance_mutation_with_catalogue_info + + for drug, tbprofiler_resistance_mutations in tbprofiler_resistance_mutations_by_drug.items(): + drug = drug.lower() + if drug not in indexed_tbprofiler_full_report_resistance_variants: + logging.warning(f"Drug {drug} not found in full report resistance variants") + continue + for idx, tbprofiler_resistance_mutation in enumerate(tbprofiler_resistance_mutations): + resistance_mutation_with_full_report_info = collect_full_report_info_for_resistance_mutation(tbprofiler_resistance_mutation, indexed_tbprofiler_full_report_resistance_variants, drug) + tbprofiler_resistance_mutations[idx] = resistance_mutation_with_full_report_info + + + adjusted_resistance_mutation_output_fieldnames = [ + 'sample_id', + 'drug', + 'gene', + 'mutation', + 'mutation_type', + 'ref_genome_accession', + 'position', + 'ref_allele', + 'alt_allele', + 'depth', + 'alt_freq', + 'tbprofiler_filter', + 'catalogue_ppv_estimate', + 'catalogue_ppv_lower_bound', + 'catalogue_ppv_upper_bound', + 'catalogue_dataset', + 'catalogue_final_confidence_grading', + 'tbprofiler_confidence', + 'tbprofiler_source', + ] + + rounded_fields = [ + 'alt_freq', + 'estimated_fraction', + 'catalogue_ppv_estimate', + 'catalogue_ppv_lower_bound', + 'catalogue_ppv_upper_bound', + ] + with open(args.output_adjusted_resistance_mutations, 'w') as f: + writer = csv.DictWriter(f, fieldnames=adjusted_resistance_mutation_output_fieldnames, extrasaction='ignore') + writer.writeheader() + for drug, tbprofiler_resistance_mutations in tbprofiler_resistance_mutations_by_drug.items(): + for mutation in tbprofiler_resistance_mutations: + for field in rounded_fields: + if field in mutation: + mutation[field] = round(mutation[field], 6) + mutation['sample_id'] = args.sample_id + writer.writerow(mutation) + + for drug, tbprofiler_other_variants in tbprofiler_other_variants_by_drug.items(): + for variant in tbprofiler_other_variants: + for field in rounded_fields: + if field in variant: + variant[field] = round(variant[field], 6) + variant['sample_id'] = args.sample_id + writer.writerow(variant) + + exit() + + adjusted_resistance_prediction_output_fieldnames = [ + 'sample_id', + 'drug', + 'num_putative_resistance_mutations_detected', + 'num_resistance_mutations_with_established_ppv', + 'sum_ppv', + 'combined_ppv', + 'ppv_threshold', + 'tbprofiler_resistance_prediction', + 'adjusted_resistance_prediction', + ] + + output = [] + for drug, resistance_mutations in tbprofiler_resistance_mutations_by_drug.items(): + tbprofiler_resistance_prediction = tbprofiler_resistance_prediction_by_drug.get(drug, {}).get('genotypic_resistance', None) + total_resistance_mutations = len(resistance_mutations) + num_resistance_mutations_with_ppv_values = len([mutation for mutation in resistance_mutations if 'ppv' in mutation]) + + sum_ppv = 0 + for mutation in resistance_mutations: + if 'ppv' in mutation: + sum_ppv += mutation['ppv'] + combined_ppv = combined_resistance_probability(resistance_mutations) + output_row = { + 'drug': drug, + 'num_putative_resistance_mutations_detected': total_resistance_mutations, + 'num_resistance_mutations_with_established_ppv': num_resistance_mutations_with_ppv_values, + 'sum_ppv': round(sum_ppv, 3), + 'combined_ppv': round(combined_ppv, 3), + 'ppv_threshold': drug_ppv_thresholds.get(drug, args.global_ppv_threshold), + 'tbprofiler_resistance_prediction': tbprofiler_resistance_prediction, + } + if output_row['ppv_threshold'] is not None and output_row['combined_ppv'] >= output_row['ppv_threshold']: + output_row['adjusted_resistance_prediction'] = 'Predicted to be Resistant' + else: + output_row['adjusted_resistance_prediction'] = 'Predicted to be Sensitive' + output.append(output_row) + + + with open(args.output_resistance_predictions, 'w') as f: + writer = csv.DictWriter(f, fieldnames=output_fieldnames, extrasaction='ignore') + writer.writeheader() + for row in output: + writer.writerow(row) + +if __name__ == '__main__': + parser = argparse.ArgumentParser(description='Adjust the TBProfiler resistance prediction output') + parser.add_argument('--sample-id', '-s', type=str, help='The sample ID') + parser.add_argument('--input-tbprofiler-resistance-mutations', type=Path, help='The input tbprofiler resistance mutations file (csv)') + parser.add_argument('--input-tbprofiler-resistance-predictions', type=Path, help='The input tbprofiler resistance predictions file (csv)') + parser.add_argument('--input-tbprofiler-full-report', type=Path, help='The input tbprofiler full report file (json)') + parser.add_argument('--input-who-mutation-catalogue', type=Path, help='') + parser.add_argument('--global-ppv-threshold', type=float, default=0.90, help='The global PPV threshold for resistance prediction') + parser.add_argument('--drug-ppv-thresholds', type=Path, help='The input drug PPV thresholds file (csv)') + parser.add_argument('--output-adjusted-resistance-predictions', type=Path, help='The output adjusted tbprofiler resistance prediction file (csv)') + parser.add_argument('--output-adjusted-resistance-mutations', type=Path, help='The output adjusted tbprofiler resistance mutations file (csv)') + args = parser.parse_args() + main(args) From ef221f52cb28947491298355bf6301fd9b525254 Mon Sep 17 00:00:00 2001 From: Dan Fornika Date: Thu, 1 Aug 2024 00:02:08 -0700 Subject: [PATCH 02/11] updates --- ...djust_tbprofiler_resistance_predictions.py | 24 +++++++++++-------- 1 file changed, 14 insertions(+), 10 deletions(-) diff --git a/bin/adjust_tbprofiler_resistance_predictions.py b/bin/adjust_tbprofiler_resistance_predictions.py index 5f520f7..49de834 100755 --- a/bin/adjust_tbprofiler_resistance_predictions.py +++ b/bin/adjust_tbprofiler_resistance_predictions.py @@ -425,9 +425,9 @@ def collect_catalogue_info_for_mutation(tbprofiler_resistance_mutation_record, i mutation_catalogue_record = indexed_catalogue[drug][gene][mutation] catalogue_dataset = "all" - tbprofiler_resistance_mutation_record['catalogue_ppv_estimate'] = mutation_catalogue_record.get('ppv_dataset_all', None) - tbprofiler_resistance_mutation_record['catalogue_ppv_lower_bound'] = mutation_catalogue_record.get('ppv_lb_dataset_all', None) - tbprofiler_resistance_mutation_record['catalogue_ppv_upper_bound'] = mutation_catalogue_record.get('ppv_ub_dataset_all', None) + tbprofiler_resistance_mutation_record['catalogue_ppv_solo_estimate'] = mutation_catalogue_record.get('ppv_dataset_all', None) + tbprofiler_resistance_mutation_record['catalogue_ppv_solo_lower_bound'] = mutation_catalogue_record.get('ppv_lb_dataset_all', None) + tbprofiler_resistance_mutation_record['catalogue_ppv_solo_upper_bound'] = mutation_catalogue_record.get('ppv_ub_dataset_all', None) tbprofiler_resistance_mutation_record['catalogue_dataset'] = catalogue_dataset tbprofiler_resistance_mutation_record['catalogue_final_confidence_grading'] = mutation_catalogue_record.get('final_confidence_grading', {}).get('category', None) @@ -478,6 +478,7 @@ def collect_full_report_info_for_resistance_mutation(tbprofiler_resistance_mutat tbprofiler_resistance_mutation_record['mutation_type'] = full_report_variant.get('type', None) tbprofiler_resistance_mutation_record['tbprofiler_confidence'] = annotation.get('confidence', None) tbprofiler_resistance_mutation_record['tbprofiler_source'] = annotation.get('source', None) + tbprofiler_resistance_mutation_record['tbprofiler_comment'] = annotation.get('comment', None) break return tbprofiler_resistance_mutation_record @@ -501,10 +502,12 @@ def format_full_report_info_for_other_variant(tbprofiler_full_report_other_varia drugs.append(drug) confidence = annotation.get('confidence', None) source = annotation.get('source', None) + comment = annotation.get('comment', None) formatted_variant_by_drug[drug] = { 'drug': drug, 'tbprofiler_confidence': confidence, 'tbprofiler_source': source, + 'tbprofiler_comment': comment, } if len(drugs) == 0: @@ -617,21 +620,22 @@ def main(args): 'depth', 'alt_freq', 'tbprofiler_filter', - 'catalogue_ppv_estimate', - 'catalogue_ppv_lower_bound', - 'catalogue_ppv_upper_bound', - 'catalogue_dataset', + 'catalogue_ppv_solo_estimate', + 'catalogue_ppv_solo_lower_bound', + 'catalogue_ppv_solo_upper_bound', 'catalogue_final_confidence_grading', + 'catalogue_dataset', 'tbprofiler_confidence', 'tbprofiler_source', + 'tbprofiler_comment', ] rounded_fields = [ 'alt_freq', 'estimated_fraction', - 'catalogue_ppv_estimate', - 'catalogue_ppv_lower_bound', - 'catalogue_ppv_upper_bound', + 'catalogue_ppv_solo_estimate', + 'catalogue_ppv_solo_lower_bound', + 'catalogue_ppv_solo_upper_bound', ] with open(args.output_adjusted_resistance_mutations, 'w') as f: writer = csv.DictWriter(f, fieldnames=adjusted_resistance_mutation_output_fieldnames, extrasaction='ignore') From 0c10b36f02852499c26fd8e0457ed1a7ffc15ba4 Mon Sep 17 00:00:00 2001 From: Dan Fornika Date: Thu, 1 Aug 2024 01:08:55 -0700 Subject: [PATCH 03/11] updates --- ...djust_tbprofiler_resistance_predictions.py | 184 +++++++++++++----- 1 file changed, 132 insertions(+), 52 deletions(-) diff --git a/bin/adjust_tbprofiler_resistance_predictions.py b/bin/adjust_tbprofiler_resistance_predictions.py index 49de834..668920f 100755 --- a/bin/adjust_tbprofiler_resistance_predictions.py +++ b/bin/adjust_tbprofiler_resistance_predictions.py @@ -38,7 +38,11 @@ def parse_tbprofiler_resistance_predictions(input_file: Path) -> dict: with open(input_file, 'r') as f: reader = csv.DictReader(f) for row in reader: - drug = row['drug'] + drug = row['drug'].lower() + if row['genotypic_resistance'] == 'R': + row['tbprofiler_resistance_prediction'] = 'Predicted Resistant' + elif row['genotypic_resistance'] == '': + row['tbprofiler_resistance_prediction'] = 'Predicted Sensitive' if drug not in tbprofiler_resistance_prediction_by_drug: tbprofiler_resistance_prediction_by_drug[drug] = row @@ -377,7 +381,7 @@ def parse_drug_ppv_thresholds(input_file: Path) -> dict: return drug_ppv_thresholds -def combined_resistance_probability(mutations): +def combine_resistance_probabilities(ppvs): """ Calculate the combined resistance probability given a list of PPVs @@ -387,13 +391,14 @@ def combined_resistance_probability(mutations): :rtype: float """ - combined_prob = 1 - for mutation in mutations: - if 'ppv' not in mutation: - continue - ppv = mutation['ppv'] - combined_prob *= (1 - ppv) - combined_prob = 1 - combined_prob + combined_prob = 0 + for ppv in ppvs: + if ppv is not None and ppv > 0.0: + if combined_prob == 0: + combined_prob = 1 + combined_prob *= (1 - ppv) + if combined_prob > 0: + combined_prob = 1 - combined_prob return combined_prob @@ -479,6 +484,7 @@ def collect_full_report_info_for_resistance_mutation(tbprofiler_resistance_mutat tbprofiler_resistance_mutation_record['tbprofiler_confidence'] = annotation.get('confidence', None) tbprofiler_resistance_mutation_record['tbprofiler_source'] = annotation.get('source', None) tbprofiler_resistance_mutation_record['tbprofiler_comment'] = annotation.get('comment', None) + tbprofiler_resistance_mutation_record['tbprofiler_variant_type'] = 'resistance' break return tbprofiler_resistance_mutation_record @@ -508,6 +514,7 @@ def format_full_report_info_for_other_variant(tbprofiler_full_report_other_varia 'tbprofiler_confidence': confidence, 'tbprofiler_source': source, 'tbprofiler_comment': comment, + 'tbprofiler_variant_type': 'other', } if len(drugs) == 0: @@ -530,29 +537,71 @@ def format_full_report_info_for_other_variant(tbprofiler_full_report_other_varia return formatted_variant_by_drug +def parse_adjusted_resistance_mutations(input_file: Path) -> dict: + """ + Parse the adjusted resistance mutations file + + :param input_file: The input adjusted resistance mutations file (csv) + :type input_file: str + :return: The parsed adjusted resistance mutations + :rtype: dict + """ + adjusted_resistance_mutations_by_drug = {} + + int_fields = [ + 'position', + ] + + float_fields = [ + 'depth', + 'alt_freq', + 'catalogue_ppv_solo_estimate', + 'catalogue_ppv_solo_lower_bound', + 'catalogue_ppv_solo_upper_bound', + ] + + with open(input_file, 'r') as f: + reader = csv.DictReader(f) + for row in reader: + for field in int_fields: + if row[field] == '': + row[field] = None + else: + try: + row[field] = int(row[field]) + except ValueError as e: + row[field] = None + for field in float_fields: + if row[field] == '': + row[field] = None + else: + try: + row[field] = float(row[field]) + except ValueError as e: + row[field] = None + + drug = row['drug'] + if drug not in adjusted_resistance_mutations_by_drug: + adjusted_resistance_mutations_by_drug[drug] = [] + adjusted_resistance_mutations_by_drug[drug].append(row) + + return adjusted_resistance_mutations_by_drug + + def main(args): log_format = '%(asctime)s - %(name)s - %(levelname)s - %(message)s' logging.basicConfig(level=logging.INFO, format=log_format) mutation_catalogue = parse_mutation_catalogue(args.input_who_mutation_catalogue) - # print(json.dumps(mutation_catalogue[0:10], indent=2)) - # exit() indexed_catalogue = index_mutation_catalogue_by_mutation_by_gene_by_drug(mutation_catalogue) tbprofiler_resistance_mutations_by_drug = parse_tbprofiler_resistance_mutations(args.input_tbprofiler_resistance_mutations) - - # print(json.dumps(tbprofiler_resistance_mutations_by_drug, indent=2)) - # exit() tbprofiler_resistance_prediction_by_drug = parse_tbprofiler_resistance_predictions(args.input_tbprofiler_resistance_predictions) - # print(json.dumps(tbprofiler_resistance_prediction_by_drug, indent=2)) - # exit() tbprofiler_full_report = parse_tbprofiler_full_report(args.input_tbprofiler_full_report) - # print(json.dumps(tbprofiler_full_report, indent=2)) - # exit() tbprofiler_full_report_resistance_variants = tbprofiler_full_report.get('dr_variants', []) @@ -582,8 +631,6 @@ def main(args): tbprofiler_other_variants_by_drug[drug] = [] tbprofiler_other_variants_by_drug[drug].append(variant) - - drug_ppv_thresholds = {} if args.drug_ppv_thresholds: drug_ppv_thresholds = parse_drug_ppv_thresholds(args.drug_ppv_thresholds) @@ -606,7 +653,6 @@ def main(args): resistance_mutation_with_full_report_info = collect_full_report_info_for_resistance_mutation(tbprofiler_resistance_mutation, indexed_tbprofiler_full_report_resistance_variants, drug) tbprofiler_resistance_mutations[idx] = resistance_mutation_with_full_report_info - adjusted_resistance_mutation_output_fieldnames = [ 'sample_id', 'drug', @@ -620,11 +666,12 @@ def main(args): 'depth', 'alt_freq', 'tbprofiler_filter', + 'catalogue_dataset', 'catalogue_ppv_solo_estimate', 'catalogue_ppv_solo_lower_bound', 'catalogue_ppv_solo_upper_bound', 'catalogue_final_confidence_grading', - 'catalogue_dataset', + 'tbprofiler_variant_type', 'tbprofiler_confidence', 'tbprofiler_source', 'tbprofiler_comment', @@ -655,54 +702,87 @@ def main(args): variant[field] = round(variant[field], 6) variant['sample_id'] = args.sample_id writer.writerow(variant) - - exit() - + + adjusted_resistance_and_other_mutations_by_drug = parse_adjusted_resistance_mutations(args.output_adjusted_resistance_mutations) + adjusted_resistance_prediction_output_fieldnames = [ 'sample_id', 'drug', - 'num_putative_resistance_mutations_detected', - 'num_resistance_mutations_with_established_ppv', - 'sum_ppv', - 'combined_ppv', + 'num_putative_drug_related_mutations_detected', + 'sum_all_mutation_ppvs', + 'combined_all_mutation_ppvs', + 'num_tbprofiler_resistance_mutations_detected', + 'sum_resistance_ppvs', + 'combined_resistance_mutation_ppvs', 'ppv_threshold', 'tbprofiler_resistance_prediction', 'adjusted_resistance_prediction', ] - output = [] - for drug, resistance_mutations in tbprofiler_resistance_mutations_by_drug.items(): - tbprofiler_resistance_prediction = tbprofiler_resistance_prediction_by_drug.get(drug, {}).get('genotypic_resistance', None) - total_resistance_mutations = len(resistance_mutations) - num_resistance_mutations_with_ppv_values = len([mutation for mutation in resistance_mutations if 'ppv' in mutation]) - - sum_ppv = 0 - for mutation in resistance_mutations: - if 'ppv' in mutation: - sum_ppv += mutation['ppv'] - combined_ppv = combined_resistance_probability(resistance_mutations) + rounded_fields = [ + 'sum_all_mutation_ppvs', + 'combined_all_mutation_ppvs', + ] + + adjusted_resistance_prediction_output = [] + for drug, tbprofiler_resistance_prediction_record in tbprofiler_resistance_prediction_by_drug.items(): + tbprofiler_resistance_prediction = tbprofiler_resistance_prediction_record['tbprofiler_resistance_prediction'] + ppv_threshold = args.global_ppv_threshold + if drug in drug_ppv_thresholds: + ppv_threshold = drug_ppv_thresholds[drug] + resistance_and_other_mutations = adjusted_resistance_and_other_mutations_by_drug.get(drug, []) + total_num_mutations_for_drug = len(resistance_and_other_mutations) + all_ppvs = [] + resistance_ppvs = [] + for mutation in resistance_and_other_mutations: + if 'catalogue_ppv_solo_estimate' in mutation: + ppv = mutation['catalogue_ppv_solo_estimate'] + if ppv is not None: + all_ppvs.append(ppv) + if mutation['tbprofiler_variant_type'] == 'resistance': + resistance_ppvs.append(ppv) + + num_mutations_with_ppv_values = len(all_ppvs) + num_resistance_mutations_with_ppv_values = len(resistance_ppvs) + + sum_all_ppv = sum(all_ppvs) + combined_all_ppv = combine_resistance_probabilities(all_ppvs) + sum_resistance_ppv = sum(resistance_ppvs) + combined_resistance_ppv = combine_resistance_probabilities(resistance_ppvs) output_row = { + 'sample_id': args.sample_id, 'drug': drug, - 'num_putative_resistance_mutations_detected': total_resistance_mutations, - 'num_resistance_mutations_with_established_ppv': num_resistance_mutations_with_ppv_values, - 'sum_ppv': round(sum_ppv, 3), - 'combined_ppv': round(combined_ppv, 3), - 'ppv_threshold': drug_ppv_thresholds.get(drug, args.global_ppv_threshold), + 'num_putative_drug_related_mutations_detected': total_num_mutations_for_drug, + 'sum_all_mutation_ppvs': sum_all_ppv, + 'combined_all_mutation_ppvs': combined_all_ppv, + 'num_tbprofiler_resistance_mutations_detected': num_resistance_mutations_with_ppv_values, + 'sum_resistance_ppvs': sum_resistance_ppv, + 'combined_resistance_mutation_ppvs': combined_resistance_ppv, + 'ppv_threshold': ppv_threshold, 'tbprofiler_resistance_prediction': tbprofiler_resistance_prediction, } - if output_row['ppv_threshold'] is not None and output_row['combined_ppv'] >= output_row['ppv_threshold']: - output_row['adjusted_resistance_prediction'] = 'Predicted to be Resistant' + if ppv_threshold is not None: + if combined_all_ppv >= ppv_threshold: + output_row['adjusted_resistance_prediction'] = 'Predicted Resistant' + else: + output_row['adjusted_resistance_prediction'] = 'Predicted Sensitive' else: - output_row['adjusted_resistance_prediction'] = 'Predicted to be Sensitive' - output.append(output_row) + output_row['adjusted_resistance_prediction'] = 'Prediction Undetermined' + + adjusted_resistance_prediction_output.append(output_row) - with open(args.output_resistance_predictions, 'w') as f: - writer = csv.DictWriter(f, fieldnames=output_fieldnames, extrasaction='ignore') + with open(args.output_adjusted_resistance_predictions, 'w') as f: + writer = csv.DictWriter(f, fieldnames=adjusted_resistance_prediction_output_fieldnames, extrasaction='ignore') writer.writeheader() - for row in output: + for row in adjusted_resistance_prediction_output: + for field in rounded_fields: + if field in row and row[field] is not None: + row[field] = round(row[field], 6) writer.writerow(row) + + if __name__ == '__main__': parser = argparse.ArgumentParser(description='Adjust the TBProfiler resistance prediction output') parser.add_argument('--sample-id', '-s', type=str, help='The sample ID') From b9b81496024ef755f547ba3a5eba7208d68d5c1a Mon Sep 17 00:00:00 2001 From: Dan Fornika Date: Thu, 1 Aug 2024 01:17:20 -0700 Subject: [PATCH 04/11] update --- bin/adjust_tbprofiler_resistance_predictions.py | 12 ++++++++++++ 1 file changed, 12 insertions(+) diff --git a/bin/adjust_tbprofiler_resistance_predictions.py b/bin/adjust_tbprofiler_resistance_predictions.py index 668920f..74ea3a4 100755 --- a/bin/adjust_tbprofiler_resistance_predictions.py +++ b/bin/adjust_tbprofiler_resistance_predictions.py @@ -602,6 +602,8 @@ def main(args): tbprofiler_resistance_prediction_by_drug = parse_tbprofiler_resistance_predictions(args.input_tbprofiler_resistance_predictions) tbprofiler_full_report = parse_tbprofiler_full_report(args.input_tbprofiler_full_report) + tbprofiler_version = tbprofiler_full_report.get('pipeline', {}).get('software_version', None) + tbdb_commit = tbprofiler_full_report.get('pipeline', {}).get('db_version', {}).get('commit', None) tbprofiler_full_report_resistance_variants = tbprofiler_full_report.get('dr_variants', []) @@ -621,6 +623,8 @@ def main(args): indexed_tbprofiler_full_report_other_variants[drug][gene] = {} mutation = formatted_variant['mutation'] formatted_variant = collect_catalogue_info_for_mutation(formatted_variant, indexed_catalogue, drug) + formatted_variant['tbprofiler_version'] = tbprofiler_version + formatted_variant['tbdb_commit'] = tbdb_commit indexed_tbprofiler_full_report_other_variants[drug][gene][mutation] = formatted_variant tbprofiler_other_variants_by_drug = {} @@ -675,6 +679,8 @@ def main(args): 'tbprofiler_confidence', 'tbprofiler_source', 'tbprofiler_comment', + 'tbprofiler_version', + 'tbdb_commit', ] rounded_fields = [ @@ -693,6 +699,8 @@ def main(args): if field in mutation: mutation[field] = round(mutation[field], 6) mutation['sample_id'] = args.sample_id + mutation['tbprofiler_version'] = tbprofiler_version + mutation['tbdb_commit'] = tbdb_commit writer.writerow(mutation) for drug, tbprofiler_other_variants in tbprofiler_other_variants_by_drug.items(): @@ -717,6 +725,8 @@ def main(args): 'ppv_threshold', 'tbprofiler_resistance_prediction', 'adjusted_resistance_prediction', + 'tbprofiler_version', + 'tbdb_commit', ] rounded_fields = [ @@ -760,6 +770,8 @@ def main(args): 'combined_resistance_mutation_ppvs': combined_resistance_ppv, 'ppv_threshold': ppv_threshold, 'tbprofiler_resistance_prediction': tbprofiler_resistance_prediction, + 'tbprofiler_version': tbprofiler_version, + 'tbdb_commit': tbdb_commit, } if ppv_threshold is not None: if combined_all_ppv >= ppv_threshold: From 7c135f8e0281b911bbdfc8bad46c3166a00246e1 Mon Sep 17 00:00:00 2001 From: Dan Fornika Date: Thu, 1 Aug 2024 09:44:02 -0700 Subject: [PATCH 05/11] updates --- ...djust_tbprofiler_resistance_predictions.py | 52 ++++++++++++------- 1 file changed, 34 insertions(+), 18 deletions(-) diff --git a/bin/adjust_tbprofiler_resistance_predictions.py b/bin/adjust_tbprofiler_resistance_predictions.py index 74ea3a4..ad5d3cb 100755 --- a/bin/adjust_tbprofiler_resistance_predictions.py +++ b/bin/adjust_tbprofiler_resistance_predictions.py @@ -477,7 +477,7 @@ def collect_full_report_info_for_resistance_mutation(tbprofiler_resistance_mutat tbprofiler_resistance_mutation_record['position'] = full_report_variant.get('pos', None) tbprofiler_resistance_mutation_record['ref_allele'] = full_report_variant.get('ref', None) tbprofiler_resistance_mutation_record['alt_allele'] = full_report_variant.get('alt', None) - tbprofiler_resistance_mutation_record['depth'] = full_report_variant.get('depth', None) + tbprofiler_resistance_mutation_record['depth_coverage'] = full_report_variant.get('depth', None) tbprofiler_resistance_mutation_record['alt_freq'] = full_report_variant.get('freq', None) tbprofiler_resistance_mutation_record['tbprofiler_filter'] = full_report_variant.get('filter', None) tbprofiler_resistance_mutation_record['mutation_type'] = full_report_variant.get('type', None) @@ -529,7 +529,7 @@ def format_full_report_info_for_other_variant(tbprofiler_full_report_other_varia formatted_variant['position'] = tbprofiler_full_report_other_variant.get('pos', None) formatted_variant['ref_allele'] = tbprofiler_full_report_other_variant.get('ref', None) formatted_variant['alt_allele'] = tbprofiler_full_report_other_variant.get('alt', None) - formatted_variant['depth'] = tbprofiler_full_report_other_variant.get('depth', None) + formatted_variant['depth_coverage'] = tbprofiler_full_report_other_variant.get('depth', None) formatted_variant['alt_freq'] = tbprofiler_full_report_other_variant.get('freq', None) formatted_variant['tbprofiler_filter'] = tbprofiler_full_report_other_variant.get('filter', None) formatted_variant['mutation_type'] = tbprofiler_full_report_other_variant.get('type', None) @@ -553,7 +553,7 @@ def parse_adjusted_resistance_mutations(input_file: Path) -> dict: ] float_fields = [ - 'depth', + 'depth_coverage', 'alt_freq', 'catalogue_ppv_solo_estimate', 'catalogue_ppv_solo_lower_bound', @@ -667,7 +667,7 @@ def main(args): 'position', 'ref_allele', 'alt_allele', - 'depth', + 'depth_coverage', 'alt_freq', 'tbprofiler_filter', 'catalogue_dataset', @@ -716,12 +716,14 @@ def main(args): adjusted_resistance_prediction_output_fieldnames = [ 'sample_id', 'drug', - 'num_putative_drug_related_mutations_detected', - 'sum_all_mutation_ppvs', - 'combined_all_mutation_ppvs', + 'total_num_putative_drug_related_mutations_detected', + 'total_num_putative_drug_related_mutations_with_ppv_values', + 'sum_all_putative_drug_related_mutation_ppvs', + 'combined_all_putative_drug_related_mutation_ppvs', 'num_tbprofiler_resistance_mutations_detected', - 'sum_resistance_ppvs', - 'combined_resistance_mutation_ppvs', + 'num_tbprofiler_resistance_mutations_with_ppv_values', + 'sum_tbprofiler_resistance_mutation_ppvs', + 'combined_tbprofiler_resistance_mutation_ppvs', 'ppv_threshold', 'tbprofiler_resistance_prediction', 'adjusted_resistance_prediction', @@ -730,8 +732,10 @@ def main(args): ] rounded_fields = [ - 'sum_all_mutation_ppvs', - 'combined_all_mutation_ppvs', + 'sum_all_putative_drug_related_mutation_ppvs', + 'combined_all_putative_drug_related_mutation_ppvs', + 'sum_tbprofiler_resistance_mutation_ppvs', + 'combined_tbprofiler_resistance_mutation_ppvs', ] adjusted_resistance_prediction_output = [] @@ -740,16 +744,26 @@ def main(args): ppv_threshold = args.global_ppv_threshold if drug in drug_ppv_thresholds: ppv_threshold = drug_ppv_thresholds[drug] + resistance_and_other_mutations = adjusted_resistance_and_other_mutations_by_drug.get(drug, []) - total_num_mutations_for_drug = len(resistance_and_other_mutations) all_ppvs = [] resistance_ppvs = [] + num_mutations_total = 0 + num_mutations_with_ppv_values = 0 + num_resistance_mutations_total = 0 + num_resistance_mutations_with_ppv_values = 0 for mutation in resistance_and_other_mutations: + num_mutations_total += 1 + if mutation['tbprofiler_variant_type'] == 'resistance': + num_resistance_mutations_total += 1 if 'catalogue_ppv_solo_estimate' in mutation: ppv = mutation['catalogue_ppv_solo_estimate'] if ppv is not None: + num_mutations_with_ppv_values += 1 all_ppvs.append(ppv) if mutation['tbprofiler_variant_type'] == 'resistance': + num_resistance_mutations_total += 1 + num_resistance_mutations_with_ppv_values += 1 resistance_ppvs.append(ppv) num_mutations_with_ppv_values = len(all_ppvs) @@ -762,12 +776,14 @@ def main(args): output_row = { 'sample_id': args.sample_id, 'drug': drug, - 'num_putative_drug_related_mutations_detected': total_num_mutations_for_drug, - 'sum_all_mutation_ppvs': sum_all_ppv, - 'combined_all_mutation_ppvs': combined_all_ppv, - 'num_tbprofiler_resistance_mutations_detected': num_resistance_mutations_with_ppv_values, - 'sum_resistance_ppvs': sum_resistance_ppv, - 'combined_resistance_mutation_ppvs': combined_resistance_ppv, + 'total_num_putative_drug_related_mutations_detected': num_mutations_total, + 'total_num_putative_drug_related_mutations_with_ppv_values': num_mutations_with_ppv_values, + 'sum_all_putative_drug_related_mutation_ppvs': sum_all_ppv, + 'combined_all_putative_drug_related_mutation_ppvs': combined_all_ppv, + 'num_tbprofiler_resistance_mutations_detected': num_resistance_mutations_total, + 'num_tbprofiler_resistance_mutations_with_ppv_values': num_resistance_mutations_with_ppv_values, + 'sum_tbprofiler_resistance_mutation_ppvs': sum_resistance_ppv, + 'combined_tbprofiler_resistance_mutation_ppvs': combined_resistance_ppv, 'ppv_threshold': ppv_threshold, 'tbprofiler_resistance_prediction': tbprofiler_resistance_prediction, 'tbprofiler_version': tbprofiler_version, From a6a7997f7b6821e7248311b1b6354de5205867d5 Mon Sep 17 00:00:00 2001 From: Dan Fornika Date: Thu, 1 Aug 2024 10:46:23 -0700 Subject: [PATCH 06/11] updates --- bin/adjust_tbprofiler_resistance_predictions.py | 4 ++-- 1 file changed, 2 insertions(+), 2 deletions(-) diff --git a/bin/adjust_tbprofiler_resistance_predictions.py b/bin/adjust_tbprofiler_resistance_predictions.py index ad5d3cb..6abfe35 100755 --- a/bin/adjust_tbprofiler_resistance_predictions.py +++ b/bin/adjust_tbprofiler_resistance_predictions.py @@ -42,7 +42,7 @@ def parse_tbprofiler_resistance_predictions(input_file: Path) -> dict: if row['genotypic_resistance'] == 'R': row['tbprofiler_resistance_prediction'] = 'Predicted Resistant' elif row['genotypic_resistance'] == '': - row['tbprofiler_resistance_prediction'] = 'Predicted Sensitive' + row['tbprofiler_resistance_prediction'] = '' if drug not in tbprofiler_resistance_prediction_by_drug: tbprofiler_resistance_prediction_by_drug[drug] = row @@ -793,7 +793,7 @@ def main(args): if combined_all_ppv >= ppv_threshold: output_row['adjusted_resistance_prediction'] = 'Predicted Resistant' else: - output_row['adjusted_resistance_prediction'] = 'Predicted Sensitive' + output_row['adjusted_resistance_prediction'] = 'Predicted Susceptible' else: output_row['adjusted_resistance_prediction'] = 'Prediction Undetermined' From e890c4407af1a5d5a4c062062e1fca184fcd6d21 Mon Sep 17 00:00:00 2001 From: Dan Fornika Date: Thu, 1 Aug 2024 13:22:21 -0700 Subject: [PATCH 07/11] integrate script into pipeline --- main.nf | 7 +++++++ modules/tbprofiler.nf | 29 +++++++++++++++++++++++++++++ nextflow.config | 5 +++-- 3 files changed, 39 insertions(+), 2 deletions(-) diff --git a/main.nf b/main.nf index a62eb60..50a9aed 100644 --- a/main.nf +++ b/main.nf @@ -7,6 +7,7 @@ nextflow.enable.dsl = 2 include { hash_files } from './modules/hash_files.nf' include { fastp } from './modules/tbprofiler.nf' include { tbprofiler } from './modules/tbprofiler.nf' +include { adjust_tbprofiler_resistance_predictions } from './modules/tbprofiler.nf' include { snpit } from './modules/tbprofiler.nf' include { check_snpit_against_tbprofiler } from './modules/tbprofiler.nf' include { rename_ref_in_alignment } from './modules/tbprofiler.nf' @@ -48,6 +49,12 @@ workflow { tbprofiler(fastp.out.reads) + if (params.adjust_tbprofiler_resistance_predictions) { + ch_who_mutation_catalogue = Channel.fromPath("${baseDir}/assets/WHO-UCN-TB-2023.6-eng_catalogue_master_file.txt") + ch_tbprofiler_outputs = tbprofiler.out.resistance_csv.join(tbprofiler.out.resistance_mutations_csv).join(tbprofiler.out.report_json) + adjust_tbprofiler_resistance_predictions(ch_tbprofiler_outputs.combine(ch_who_mutation_catalogue)) + } + if (params.rename_ref) { ch_ref = Channel.fromPath("${baseDir}/assets/NC_000962.3.fa") rename_ref_in_alignment(tbprofiler.out.alignment) diff --git a/modules/tbprofiler.nf b/modules/tbprofiler.nf index 3fd0f6b..a62ab39 100644 --- a/modules/tbprofiler.nf +++ b/modules/tbprofiler.nf @@ -121,6 +121,35 @@ process tbprofiler { """ } + +process adjust_tbprofiler_resistance_predictions { + + tag { sample_id } + + publishDir "${params.outdir}/${sample_id}", mode: 'copy', pattern: "${sample_id}_tbprofiler_resistance_*adjusted.csv" + + input: + tuple val(sample_id), path(tbprofiler_resistance_csv), path(tbprofiler_resistance_mutations_csv), path(tbprofiler_full_report_json), path(who_mutation_catalogue) + + output: + tuple val(sample_id), path("${sample_id}_tbprofiler_resistance_adjusted.csv"), emit: adjusted_resistance_csv + tuple val(sample_id), path("${sample_id}_tbprofiler_resistance_mutations_adjusted.csv"), emit: adjusted_resistance_mutations_csv + + script: + """ + adjust_tbprofiler_resistance_predictions.py \ + --sample-id ${sample_id} \ + --input-tbprofiler-resistance-mutations ${tbprofiler_resistance_mutations_csv} \ + --input-tbprofiler-resistance-predictions ${tbprofiler_resistance_csv} \ + --input-tbprofiler-full-report ${tbprofiler_full_report_json} \ + --input-who-mutation-catalogue ${who_mutation_catalogue} \ + --output-adjusted-resistance-mutations ${sample_id}_tbprofiler_resistance_mutations_adjusted.csv \ + --output-adjusted-resistance-predictions ${sample_id}_tbprofiler_resistance_adjusted.csv + + """ +} + + process rename_ref_in_alignment { tag { sample_id } diff --git a/nextflow.config b/nextflow.config index c18f920..42c30c4 100644 --- a/nextflow.config +++ b/nextflow.config @@ -15,14 +15,15 @@ params { fastq_search_path = makeFastqSearchPath( illumina_suffixes, fastq_exts ) fastq_input = 'NO_FILE' samplesheet_input = 'NO_FILE' - platform= 'illumina' - mapper= 'bwa' + platform = 'illumina' + mapper = 'bwa' caller = 'bcftools' min_depth = 10 min_af_used_for_calling = 0.1 min_af_used_for_prediction = 0.1 ref_name = 'NC_000962.3' rename_ref = false + adjust_tbprofiler_resistance_predictions = false outdir = 'results' pipeline_short_name = parsePipelineName(manifest.toMap().get('name')) pipeline_minor_version = parseMinorVersion(manifest.toMap().get('version')) From 2b500c331bddb2ac46a833060991e3707531e430 Mon Sep 17 00:00:00 2001 From: Dan Fornika Date: Fri, 2 Aug 2024 15:06:55 -0700 Subject: [PATCH 08/11] Begin incorporating custom mutation resistance prediction eligibility criteria into resistance prediction adjustment script --- ...djust_tbprofiler_resistance_predictions.py | 44 ++++++++++++++++--- nextflow.config | 1 + 2 files changed, 40 insertions(+), 5 deletions(-) diff --git a/bin/adjust_tbprofiler_resistance_predictions.py b/bin/adjust_tbprofiler_resistance_predictions.py index 6abfe35..884ee47 100755 --- a/bin/adjust_tbprofiler_resistance_predictions.py +++ b/bin/adjust_tbprofiler_resistance_predictions.py @@ -292,14 +292,14 @@ def parse_mutation_catalogue(catalogue_path): 'interim_grading': interim_grading, 'associated_with_resistance': associated_with_resistance, } - + parsed_record[cleaned_key] = row[k] # The 'genomic_position' field is always "(see \"Genomic_coordinates\" sheet)" parsed_record.pop('genomic_position', None) catalogue.append(parsed_record) - + return catalogue @@ -436,9 +436,6 @@ def collect_catalogue_info_for_mutation(tbprofiler_resistance_mutation_record, i tbprofiler_resistance_mutation_record['catalogue_dataset'] = catalogue_dataset tbprofiler_resistance_mutation_record['catalogue_final_confidence_grading'] = mutation_catalogue_record.get('final_confidence_grading', {}).get('category', None) - #print(json.dumps(tbprofiler_resistance_mutation_record, indent=2)) - #exit() - return tbprofiler_resistance_mutation_record @@ -588,6 +585,42 @@ def parse_adjusted_resistance_mutations(input_file: Path) -> dict: return adjusted_resistance_mutations_by_drug +def parse_custom_mutation_resistance_prediction_eligibility_criteria(input_file: Path) -> dict: + """ + Parse the custom mutation resistance prediction eligibility criteria file. + + Input file should be a CSV with the following columns: + - drug + - gene + - mutation + + ...along with an arbitrary number of additional columns containing eligibility criteria. + + For each eligibility criterion, the column name should be the criterion name, and the value should indicate + whether the mutation meets the criterion (e.g. 'True' or 'False'). + """ + custom_mutation_resistance_prediction_eligibility_criteria = {} + + with open(input_file, 'r') as f: + reader = csv.DictReader(f) + for row in reader: + drug = row['drug'] + if drug not in custom_mutation_resistance_prediction_eligibility_criteria: + custom_mutation_resistance_prediction_eligibility_criteria[drug] = {} + gene = row['gene'] + if gene not in custom_mutation_resistance_prediction_eligibility_criteria[drug]: + custom_mutation_resistance_prediction_eligibility_criteria[drug][gene] = {} + mutation = row['mutation'] + criteria = {} + for key, value in row.items(): + if key in ['drug', 'gene', 'mutation']: + continue + criteria[key] = value + custom_mutation_resistance_prediction_eligibility_criteria[drug][gene][mutation] = criteria + + return custom_mutation_resistance_prediction_eligibility_criteria + + def main(args): log_format = '%(asctime)s - %(name)s - %(levelname)s - %(message)s' @@ -818,6 +851,7 @@ def main(args): parser.add_argument('--input-tbprofiler-resistance-predictions', type=Path, help='The input tbprofiler resistance predictions file (csv)') parser.add_argument('--input-tbprofiler-full-report', type=Path, help='The input tbprofiler full report file (json)') parser.add_argument('--input-who-mutation-catalogue', type=Path, help='') + parser.add_argument('--input-custom-mutation-resistance-prediction-eligibility-criteria', type=Path, help='') parser.add_argument('--global-ppv-threshold', type=float, default=0.90, help='The global PPV threshold for resistance prediction') parser.add_argument('--drug-ppv-thresholds', type=Path, help='The input drug PPV thresholds file (csv)') parser.add_argument('--output-adjusted-resistance-predictions', type=Path, help='The output adjusted tbprofiler resistance prediction file (csv)') diff --git a/nextflow.config b/nextflow.config index 42c30c4..209edcd 100644 --- a/nextflow.config +++ b/nextflow.config @@ -24,6 +24,7 @@ params { ref_name = 'NC_000962.3' rename_ref = false adjust_tbprofiler_resistance_predictions = false + custom_mutation_resistance_prediction_eligibility_criteria = 'NO_FILE' outdir = 'results' pipeline_short_name = parsePipelineName(manifest.toMap().get('name')) pipeline_minor_version = parseMinorVersion(manifest.toMap().get('version')) From 49d2b2664a460fb39d8a4f60ee04f7d44c108abe Mon Sep 17 00:00:00 2001 From: Dan Fornika Date: Fri, 2 Aug 2024 23:19:01 -0700 Subject: [PATCH 09/11] incorporate custom mutation resistance prediction eligibility criteria --- ...djust_tbprofiler_resistance_predictions.py | 115 ++++++++++++++++-- 1 file changed, 107 insertions(+), 8 deletions(-) diff --git a/bin/adjust_tbprofiler_resistance_predictions.py b/bin/adjust_tbprofiler_resistance_predictions.py index 884ee47..c643f4a 100755 --- a/bin/adjust_tbprofiler_resistance_predictions.py +++ b/bin/adjust_tbprofiler_resistance_predictions.py @@ -463,8 +463,6 @@ def collect_full_report_info_for_resistance_mutation(tbprofiler_resistance_mutat return tbprofiler_resistance_mutation_record full_report_variant = indexed_tbprofiler_full_report_resistance_variants[drug][gene][mutation] - # print(json.dumps(full_report_variant, indent=2)) - # exit() for annotation in full_report_variant['annotation']: if annotation['type'] == 'drug_resistance' or annotation['type'] == 'who_confidence': @@ -523,6 +521,8 @@ def format_full_report_info_for_other_variant(tbprofiler_full_report_other_varia formatted_variant['ref_genome_accession'] = "NC_000962.3" formatted_variant['gene'] = tbprofiler_full_report_other_variant.get('gene_name', None) formatted_variant['mutation'] = tbprofiler_full_report_other_variant.get('change', None) + formatted_variant['nucleotide_change'] = tbprofiler_full_report_other_variant.get('nucleotide_change', None) + formatted_variant['protein_change'] = tbprofiler_full_report_other_variant.get('protein_change', None) formatted_variant['position'] = tbprofiler_full_report_other_variant.get('pos', None) formatted_variant['ref_allele'] = tbprofiler_full_report_other_variant.get('ref', None) formatted_variant['alt_allele'] = tbprofiler_full_report_other_variant.get('alt', None) @@ -605,6 +605,7 @@ def parse_custom_mutation_resistance_prediction_eligibility_criteria(input_file: reader = csv.DictReader(f) for row in reader: drug = row['drug'] + drug = drug.lower() if drug not in custom_mutation_resistance_prediction_eligibility_criteria: custom_mutation_resistance_prediction_eligibility_criteria[drug] = {} gene = row['gene'] @@ -621,13 +622,78 @@ def parse_custom_mutation_resistance_prediction_eligibility_criteria(input_file: return custom_mutation_resistance_prediction_eligibility_criteria +def determine_mutation_resistance_prediction_eligibility(mutation: dict, custom_mutation_resistance_prediction_eligibility_criteria: dict) -> bool: + """ + Determine if a mutation is eligible for resistance prediction based on custom eligibility criteria. + + :param mutation: The mutation + :type mutation: dict + :param custom_mutation_resistance_prediction_eligibility_criteria: The custom mutation resistance prediction eligibility criteria + :type custom_mutation_resistance_prediction_eligibility_criteria: dict + :return: Whether the mutation is eligible for resistance prediction + """ + # The input mutation is expected to have the keys: 'drug', 'gene', and 'mutation' + # If not, we don't have anything to say about its eligibility. + + eligibility = None + drug = mutation.get('drug', None) + if drug is None: + logging.warning(f"No drug available when checking eligibility for mutation {mutation}") + return eligibility + gene = mutation.get('gene', None) + if gene is None: + logging.warning(f"No gene available when checking eligibility for mutation {mutation}") + return eligibility + mutation_mutation = mutation.get('mutation', None) + if mutation_mutation is None: + logging.warning(f"No mutation available when checking eligibility for mutation {mutation}") + return eligibility + + + # A mutation must meet at least one criterion to be eligible. + # All mutations with tbprofiler_variant_type == 'resistance' are eligible by default, + # but may lose eligibility if they fail to meet any other custom criteria + + tbprofiler_variant_type = mutation.get('tbprofiler_variant_type', None) + if drug not in custom_mutation_resistance_prediction_eligibility_criteria: + if tbprofiler_variant_type == 'resistance': + eligibility = True + else: + eligibility = False + return eligibility + if gene not in custom_mutation_resistance_prediction_eligibility_criteria[drug]: + if tbprofiler_variant_type == 'resistance': + eligibility = True + else: + eligibility = False + return eligibility + if mutation not in custom_mutation_resistance_prediction_eligibility_criteria[drug][gene]: + eligibility = False + return eligibility + criteria = custom_mutation_resistance_prediction_eligibility_criteria[drug][gene][mutation] + + for criterion, value in criteria.items(): + if value.lower() == 'true': + eligibility = True + elif value.lower() == 'false': + eligibility = False + else: + eligibility = False + + return eligibility + + def main(args): log_format = '%(asctime)s - %(name)s - %(levelname)s - %(message)s' logging.basicConfig(level=logging.INFO, format=log_format) - mutation_catalogue = parse_mutation_catalogue(args.input_who_mutation_catalogue) + custom_mutation_resistance_prediction_eligibility_criteria = {} + if args.input_custom_mutation_resistance_prediction_eligibility_criteria: + custom_mutation_resistance_prediction_eligibility_criteria = parse_custom_mutation_resistance_prediction_eligibility_criteria(args.custom_mutation_resistance_prediction_eligibility_criteria) + + mutation_catalogue = parse_mutation_catalogue(args.input_who_mutation_catalogue) indexed_catalogue = index_mutation_catalogue_by_mutation_by_gene_by_drug(mutation_catalogue) tbprofiler_resistance_mutations_by_drug = parse_tbprofiler_resistance_mutations(args.input_tbprofiler_resistance_mutations) @@ -668,6 +734,9 @@ def main(args): tbprofiler_other_variants_by_drug[drug] = [] tbprofiler_other_variants_by_drug[drug].append(variant) + # The user may optionally supply a file containing drug-specific PPV thresholds. + # If they don't then a global threshold will be used, as defined by + # the '--global-ppv-threshold' argument. drug_ppv_thresholds = {} if args.drug_ppv_thresholds: drug_ppv_thresholds = parse_drug_ppv_thresholds(args.drug_ppv_thresholds) @@ -683,18 +752,40 @@ def main(args): for drug, tbprofiler_resistance_mutations in tbprofiler_resistance_mutations_by_drug.items(): drug = drug.lower() - if drug not in indexed_tbprofiler_full_report_resistance_variants: - logging.warning(f"Drug {drug} not found in full report resistance variants") - continue for idx, tbprofiler_resistance_mutation in enumerate(tbprofiler_resistance_mutations): resistance_mutation_with_full_report_info = collect_full_report_info_for_resistance_mutation(tbprofiler_resistance_mutation, indexed_tbprofiler_full_report_resistance_variants, drug) tbprofiler_resistance_mutations[idx] = resistance_mutation_with_full_report_info + # For each resistance mutation, determine if it is eligible for resistance prediction. + # These mutations are eligible by default, but may lose eligibility if they fail to meet + # any custom criteria. + for drug, tbprofiler_resistance_mutations in tbprofiler_resistance_mutations_by_drug.items(): + for tbprofiler_resistance_mutation in tbprofiler_resistance_mutations: + mutation_eligibility = determine_mutation_resistance_prediction_eligibility( + tbprofiler_resistance_mutation, + custom_mutation_resistance_prediction_eligibility_criteria + ) + tbprofiler_resistance_mutation['eligible_for_resistance_prediction'] = mutation_eligibility + + # For each other variant, determine if it is eligible for resistance prediction. + # These variants are *not* eligible by default, but may gain eligibility if they meet + # all custom criteria. + for drug, tbprofiler_other_variants in tbprofiler_other_variants_by_drug.items(): + for tbprofiler_other_variant in tbprofiler_other_variants: + mutation_eligibility = determine_mutation_resistance_prediction_eligibility( + tbprofiler_other_variant, + custom_mutation_resistance_prediction_eligibility_criteria + ) + tbprofiler_other_variant['eligible_for_resistance_prediction'] = mutation_eligibility + + adjusted_resistance_mutation_output_fieldnames = [ 'sample_id', 'drug', 'gene', 'mutation', + 'nucleotide_change', + 'protein_change', 'mutation_type', 'ref_genome_accession', 'position', @@ -712,6 +803,7 @@ def main(args): 'tbprofiler_confidence', 'tbprofiler_source', 'tbprofiler_comment', + 'eligible_for_resistance_prediction', 'tbprofiler_version', 'tbdb_commit', ] @@ -744,6 +836,14 @@ def main(args): variant['sample_id'] = args.sample_id writer.writerow(variant) + + + # + # End of mutation-specific processing. + # Now that we've saved the detaled mutation information, we can proceed to the resistance prediction step. + # + + adjusted_resistance_and_other_mutations_by_drug = parse_adjusted_resistance_mutations(args.output_adjusted_resistance_mutations) adjusted_resistance_prediction_output_fieldnames = [ @@ -817,7 +917,6 @@ def main(args): 'num_tbprofiler_resistance_mutations_with_ppv_values': num_resistance_mutations_with_ppv_values, 'sum_tbprofiler_resistance_mutation_ppvs': sum_resistance_ppv, 'combined_tbprofiler_resistance_mutation_ppvs': combined_resistance_ppv, - 'ppv_threshold': ppv_threshold, 'tbprofiler_resistance_prediction': tbprofiler_resistance_prediction, 'tbprofiler_version': tbprofiler_version, 'tbdb_commit': tbdb_commit, @@ -852,8 +951,8 @@ def main(args): parser.add_argument('--input-tbprofiler-full-report', type=Path, help='The input tbprofiler full report file (json)') parser.add_argument('--input-who-mutation-catalogue', type=Path, help='') parser.add_argument('--input-custom-mutation-resistance-prediction-eligibility-criteria', type=Path, help='') - parser.add_argument('--global-ppv-threshold', type=float, default=0.90, help='The global PPV threshold for resistance prediction') parser.add_argument('--drug-ppv-thresholds', type=Path, help='The input drug PPV thresholds file (csv)') + parser.add_argument('--global-ppv-threshold', type=float, default=0.90, help='The global PPV threshold') parser.add_argument('--output-adjusted-resistance-predictions', type=Path, help='The output adjusted tbprofiler resistance prediction file (csv)') parser.add_argument('--output-adjusted-resistance-mutations', type=Path, help='The output adjusted tbprofiler resistance mutations file (csv)') args = parser.parse_args() From 932684443e51111c2b6e71fa589a98e943b4a884 Mon Sep 17 00:00:00 2001 From: Dan Fornika Date: Sat, 3 Aug 2024 01:46:41 -0700 Subject: [PATCH 10/11] Incorporate custom mutation resistance prediction eligibility criteria into pipeline --- main.nf | 9 +++++++-- modules/tbprofiler.nf | 7 +++++-- nextflow.config | 2 +- 3 files changed, 13 insertions(+), 5 deletions(-) diff --git a/main.nf b/main.nf index 50a9aed..f4a2161 100644 --- a/main.nf +++ b/main.nf @@ -50,11 +50,16 @@ workflow { tbprofiler(fastp.out.reads) if (params.adjust_tbprofiler_resistance_predictions) { - ch_who_mutation_catalogue = Channel.fromPath("${baseDir}/assets/WHO-UCN-TB-2023.6-eng_catalogue_master_file.txt") ch_tbprofiler_outputs = tbprofiler.out.resistance_csv.join(tbprofiler.out.resistance_mutations_csv).join(tbprofiler.out.report_json) - adjust_tbprofiler_resistance_predictions(ch_tbprofiler_outputs.combine(ch_who_mutation_catalogue)) + + ch_who_mutation_catalogue = Channel.fromPath("${baseDir}/assets/WHO-UCN-TB-2023.6-eng_catalogue_master_file.txt") + + ch_custom_mutation_resistance_prediction_eligibility_criteria = Channel.fromPath(params.custom_mutation_resistance_prediction_eligibility_criteria) + + adjust_tbprofiler_resistance_predictions(ch_tbprofiler_outputs.combine(ch_who_mutation_catalogue).combine(ch_custom_mutation_resistance_prediction_eligibility_criteria)) } + if (params.rename_ref) { ch_ref = Channel.fromPath("${baseDir}/assets/NC_000962.3.fa") rename_ref_in_alignment(tbprofiler.out.alignment) diff --git a/modules/tbprofiler.nf b/modules/tbprofiler.nf index a62ab39..f6600ef 100644 --- a/modules/tbprofiler.nf +++ b/modules/tbprofiler.nf @@ -129,13 +129,15 @@ process adjust_tbprofiler_resistance_predictions { publishDir "${params.outdir}/${sample_id}", mode: 'copy', pattern: "${sample_id}_tbprofiler_resistance_*adjusted.csv" input: - tuple val(sample_id), path(tbprofiler_resistance_csv), path(tbprofiler_resistance_mutations_csv), path(tbprofiler_full_report_json), path(who_mutation_catalogue) + tuple val(sample_id), path(tbprofiler_resistance_csv), path(tbprofiler_resistance_mutations_csv), path(tbprofiler_full_report_json), path(who_mutation_catalogue), path(custom_mutation_resistance_prediction_eligibility_criteria) output: tuple val(sample_id), path("${sample_id}_tbprofiler_resistance_adjusted.csv"), emit: adjusted_resistance_csv tuple val(sample_id), path("${sample_id}_tbprofiler_resistance_mutations_adjusted.csv"), emit: adjusted_resistance_mutations_csv script: + custom_criteria = '' + custom_criteria = custom_mutation_resistance_prediction_eligibility_criteria.toString() == "NO_FILE" ? "" : "--custom-mutation-resistance-prediction-eligibility-criteria " + custom_mutation_resistance_prediction_eligibility_criteria.toString() """ adjust_tbprofiler_resistance_predictions.py \ --sample-id ${sample_id} \ @@ -143,9 +145,10 @@ process adjust_tbprofiler_resistance_predictions { --input-tbprofiler-resistance-predictions ${tbprofiler_resistance_csv} \ --input-tbprofiler-full-report ${tbprofiler_full_report_json} \ --input-who-mutation-catalogue ${who_mutation_catalogue} \ + ${custom_criteria} \ --output-adjusted-resistance-mutations ${sample_id}_tbprofiler_resistance_mutations_adjusted.csv \ --output-adjusted-resistance-predictions ${sample_id}_tbprofiler_resistance_adjusted.csv - + """ } diff --git a/nextflow.config b/nextflow.config index 209edcd..ac17936 100644 --- a/nextflow.config +++ b/nextflow.config @@ -4,7 +4,7 @@ manifest { description = 'BCCDC-PHL TBProfiler Nextflow Wrapper' mainScript = 'main.nf' nextflowVersion = '>=20.01.0' - version = '0.2.2' + version = '0.2.3' } params { From 39f7e00a6f895f734195592c60cf6d741b142266 Mon Sep 17 00:00:00 2001 From: Dan Fornika Date: Sat, 3 Aug 2024 03:22:57 -0700 Subject: [PATCH 11/11] updates --- bin/adjust_tbprofiler_resistance_predictions.py | 6 +++--- modules/tbprofiler.nf | 2 +- 2 files changed, 4 insertions(+), 4 deletions(-) diff --git a/bin/adjust_tbprofiler_resistance_predictions.py b/bin/adjust_tbprofiler_resistance_predictions.py index c643f4a..93eefc7 100755 --- a/bin/adjust_tbprofiler_resistance_predictions.py +++ b/bin/adjust_tbprofiler_resistance_predictions.py @@ -667,10 +667,10 @@ def determine_mutation_resistance_prediction_eligibility(mutation: dict, custom_ else: eligibility = False return eligibility - if mutation not in custom_mutation_resistance_prediction_eligibility_criteria[drug][gene]: + if mutation_mutation not in custom_mutation_resistance_prediction_eligibility_criteria[drug][gene]: eligibility = False return eligibility - criteria = custom_mutation_resistance_prediction_eligibility_criteria[drug][gene][mutation] + criteria = custom_mutation_resistance_prediction_eligibility_criteria[drug][gene][mutation_mutation] for criterion, value in criteria.items(): if value.lower() == 'true': @@ -690,7 +690,7 @@ def main(args): custom_mutation_resistance_prediction_eligibility_criteria = {} if args.input_custom_mutation_resistance_prediction_eligibility_criteria: - custom_mutation_resistance_prediction_eligibility_criteria = parse_custom_mutation_resistance_prediction_eligibility_criteria(args.custom_mutation_resistance_prediction_eligibility_criteria) + custom_mutation_resistance_prediction_eligibility_criteria = parse_custom_mutation_resistance_prediction_eligibility_criteria(args.input_custom_mutation_resistance_prediction_eligibility_criteria) mutation_catalogue = parse_mutation_catalogue(args.input_who_mutation_catalogue) diff --git a/modules/tbprofiler.nf b/modules/tbprofiler.nf index f6600ef..09cf765 100644 --- a/modules/tbprofiler.nf +++ b/modules/tbprofiler.nf @@ -137,7 +137,7 @@ process adjust_tbprofiler_resistance_predictions { script: custom_criteria = '' - custom_criteria = custom_mutation_resistance_prediction_eligibility_criteria.toString() == "NO_FILE" ? "" : "--custom-mutation-resistance-prediction-eligibility-criteria " + custom_mutation_resistance_prediction_eligibility_criteria.toString() + custom_criteria = custom_mutation_resistance_prediction_eligibility_criteria.toString() == "NO_FILE" ? "" : "--input-custom-mutation-resistance-prediction-eligibility-criteria " + custom_mutation_resistance_prediction_eligibility_criteria.toString() """ adjust_tbprofiler_resistance_predictions.py \ --sample-id ${sample_id} \